rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(5), GLUD1(1), OAT(2)	2436277	10	10	10	0	0	0	6	1	3	0	0.0985	0.00251	0.672
2	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	213542	3	3	3	0	0	0	0	1	2	0	0.858	0.00308	0.672
3	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(4), NRG2(1), NRG3(3), PRKCA(1), PSEN1(1)	3787830	13	13	13	1	1	2	1	6	3	0	0.168	0.00328	0.672
4	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	757351	5	5	5	1	1	0	0	3	1	0	0.725	0.00436	0.672
5	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(4), PARK2(2), SNCAIP(3), UBE2L3(1)	2673213	10	10	10	1	0	1	1	6	2	0	0.284	0.00751	0.925
6	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), CAD(4), CPS1(1), EPRS(1), GAD1(2), GAD2(2), GCLC(3), GCLM(1), GFPT1(2), GLS(5), GLUD1(1), GLUL(2), GMPS(1), GOT2(1), GPT(2), PPAT(1), QARS(3)	14031798	34	32	34	2	0	2	8	15	9	0	0.0135	0.0230	1.000
7	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(3), AGTR2(1), KNG1(3), NOS3(1)	4215483	12	12	12	0	2	0	2	7	1	0	0.0527	0.0253	1.000
8	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), GREB1(6), HSPB2(1), MTA1(4), MTA3(2), PDZK1(1), TUBA8(1)	4765391	16	14	16	2	1	4	3	4	4	0	0.161	0.0292	1.000
9	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(2), HADHA(2)	2302526	7	7	7	0	0	2	2	3	0	0	0.119	0.0386	1.000
10	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT1(2), SHMT2(3)	1788627	6	6	6	0	1	0	2	2	1	0	0.186	0.0389	1.000
11	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(1), GART(2), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(2), SHMT2(3)	7532575	19	19	19	2	1	3	5	6	4	0	0.0631	0.0398	1.000
12	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(5), GLUD1(1)	1921945	6	6	6	0	0	0	4	1	1	0	0.184	0.0433	1.000
13	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), FDXR(3), SHMT1(2)	6762762	16	16	16	1	1	1	4	7	3	0	0.111	0.0449	1.000
14	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(1)	893891	4	4	4	1	0	0	1	1	2	0	0.870	0.0471	1.000
15	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB3A(2), RAB6A(2)	1776569	6	6	6	1	0	1	0	4	1	0	0.678	0.0495	1.000
16	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASNS(1), CAD(4), CRAT(1), DARS(3), DDO(1), GAD1(2), GAD2(2), GOT2(1), GPT(2), PC(5)	11017816	28	25	28	2	0	5	2	11	10	0	0.0414	0.0645	1.000
17	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(4), ACOX1(1), ACOX3(3), ELOVL6(2), FADS1(1), FASN(4), HADHA(2)	6270892	17	14	17	1	1	4	0	9	3	0	0.0455	0.0707	1.000
18	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(1), SDHA(1), SDHD(1), UQCRC1(1)	2760417	6	6	6	1	1	2	2	0	1	0	0.365	0.0764	1.000
19	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(1), GLS(5), GLUD1(1)	3247694	8	8	8	0	0	0	4	1	3	0	0.151	0.0769	1.000
20	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	LDLR(2), LPL(4)	2241756	6	6	6	1	1	1	0	2	2	0	0.530	0.0860	1.000
21	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(2), ADORA3(1), P2RY1(2), P2RY2(1)	2424634	6	6	6	0	1	1	2	2	0	0	0.144	0.103	1.000
22	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(1), DPYS(1), ENPP1(2), ENPP3(1), ILVBL(3), PANK1(2), PANK2(1), PANK3(1), PPCDC(1), UPB1(1)	7326739	15	15	15	1	2	1	3	3	6	0	0.156	0.104	1.000
23	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IFNG(2), IL18(1), IL2(1)	1254329	4	4	4	0	0	0	0	2	2	0	0.623	0.109	1.000
24	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(1), SHMT1(2), SHMT2(3)	2366575	6	6	6	1	1	0	2	2	1	0	0.472	0.109	1.000
25	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(3), AASS(3), KARS(1)	2887466	7	7	7	1	0	2	2	3	0	0	0.338	0.112	1.000
26	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	HMOX1(1), IL10RA(3), IL10RB(1), JAK1(2), STAT1(2), STAT3(1), STAT5A(2), TNF(1)	5178247	13	13	13	2	2	1	0	6	4	0	0.538	0.113	1.000
27	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), RDH11(1), RDH12(3), RDH13(1)	2006027	6	6	6	1	0	1	0	4	1	0	0.556	0.119	1.000
28	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), UGDH(1)	3609475	8	8	8	1	2	0	3	2	1	0	0.306	0.120	1.000
29	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(1), PC(5), SLC25A11(3)	3908337	12	11	12	2	1	0	1	7	3	0	0.505	0.122	1.000
30	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(3), ACADM(2), ACADSB(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), DPYD(1), DPYS(1), EHHADH(1), GAD1(2), GAD2(2), HADHA(2), UPB1(1)	12244829	26	26	26	3	2	5	6	8	5	0	0.0467	0.144	1.000
31	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(2), RANBP2(5)	3499668	9	9	9	2	1	1	1	5	1	0	0.522	0.147	1.000
32	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD86(2), GRB2(1), ICOS(1), IL2(1), ITK(1), PIK3CA(6), PIK3R1(2)	5352015	14	13	12	2	1	4	0	6	3	0	0.331	0.147	1.000
33	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), SHMT1(2)	6354375	13	13	13	1	1	0	4	5	3	0	0.213	0.158	1.000
34	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), SHMT1(2)	6354375	13	13	13	1	1	0	4	5	3	0	0.213	0.158	1.000
35	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), SHMT1(2)	6354375	13	13	13	1	1	0	4	5	3	0	0.213	0.158	1.000
36	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(1), DPYS(1), ENPP1(2), ENPP3(1), PANK1(2), PANK2(1), PANK3(1), UPB1(1)	5901772	11	11	11	0	2	1	2	2	4	0	0.0635	0.158	1.000
37	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AMD1(2), AOC2(2), ARG1(1), ARG2(1), CPS1(1), GATM(1), MAOA(1), MAOB(3), NAGS(1), ODC1(1), SAT2(1)	12415512	26	26	26	3	4	1	4	9	8	0	0.0935	0.173	1.000
38	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CRY1(1), CSNK1E(3), PER1(4)	3595871	9	9	9	2	2	0	1	5	1	0	0.545	0.176	1.000
39	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3)	3369494	7	7	7	0	2	0	2	2	1	0	0.122	0.176	1.000
40	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3)	3369494	7	7	7	0	2	0	2	2	1	0	0.122	0.176	1.000
41	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(1), FH(2), IDH2(1), OGDH(5), SDHA(1), SUCLA2(1)	3979992	11	10	11	2	0	2	0	4	5	0	0.425	0.179	1.000
42	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(1), CAD(4), CPS1(1), EPRS(1), GAD1(2), GAD2(2), GCLC(3), GCLM(1), GFPT1(2), GFPT2(2), GLS(5), GLUD1(1), GLUL(2), GMPS(1), GNPNAT1(1), GOT2(1), GPT(2), GSR(1), NAGK(1), PPAT(1), QARS(3)	16668961	39	37	39	4	0	2	11	17	9	0	0.0290	0.180	1.000
43	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15B(2), ALOX5(2), DPEP1(1), GGT1(1), PLA2G6(2), PTGES(1), PTGS2(1), TBXAS1(1)	6572016	14	13	14	1	1	1	2	6	4	0	0.185	0.182	1.000
44	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(1), JAK1(2), JAK2(1), PTPRU(2), STAT1(2)	4807806	12	12	12	2	1	0	0	8	3	0	0.646	0.191	1.000
45	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), EHHADH(1), HADHA(2)	5139811	10	10	10	1	2	0	3	4	1	0	0.177	0.196	1.000
46	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(1), CTH(1), GGT1(1), MARS(1), MAT1A(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SCLY(1)	5243911	13	12	13	2	0	3	2	4	4	0	0.418	0.216	1.000
47	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(8), HMGB2(2)	4479170	10	10	10	2	1	2	4	2	1	0	0.271	0.222	1.000
48	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(2), MBTPS1(1), MBTPS2(1), SCAP(1), SREBF1(2), SREBF2(5)	5207942	14	14	14	3	1	0	3	6	4	0	0.490	0.223	1.000
49	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ACADM(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), DPYD(1), DPYS(1), EHHADH(1), GAD1(2), GAD2(2), HADHA(2), UPB1(1)	11394131	22	22	22	2	2	3	4	8	5	0	0.0518	0.225	1.000
50	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(3), PLA2G2D(1), PLA2G4A(1), PLA2G6(2)	4449110	8	8	8	0	0	5	0	2	1	0	0.0493	0.226	1.000
51	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(1), HADHA(2), HSD17B4(1), NTAN1(1), SIRT7(3)	5008608	9	9	9	1	1	1	3	4	0	0	0.203	0.237	1.000
52	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(1), IL18(1), ITGB1(1), KLRC3(1), PAK1(2), PIK3CA(6), PIK3R1(2), PTK2B(1), VAV1(3)	7923065	19	17	17	3	2	5	1	5	5	1	0.315	0.245	1.000
53	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(2), ELK1(1), GRB2(1), INS(1), IRS1(2), PIK3CA(6), PIK3R1(2), RAF1(3), RASA1(2), SLC2A4(2), SOS1(2)	10713694	24	22	22	3	4	6	2	8	4	0	0.0701	0.256	1.000
54	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT2(1), AKT3(1), BPNT1(3), GRB2(1), MAPK1(1), PIK3CA(6), PIK3CD(1), PTK2B(1), SOS1(2)	8199949	17	14	15	2	2	5	1	5	4	0	0.0654	0.262	1.000
55	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(1), HADHA(2)	2052238	4	4	4	1	0	0	2	2	0	0	0.593	0.267	1.000
56	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	PON1(1), PON2(2), RDH11(1), RDH12(3), RDH13(1)	3766454	8	8	8	1	0	1	0	6	1	0	0.439	0.270	1.000
57	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(2), ELK1(1), GRB2(1), IGF1R(2), IRS1(2), PIK3CA(6), PIK3R1(2), RAF1(3), RASA1(2), SOS1(2)	10400555	23	21	21	3	3	6	2	7	5	0	0.105	0.273	1.000
58	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(3), ABAT(1), ACY3(1), ADSL(1), ADSSL1(2), AGXT(1), AGXT2(1), ASNS(1), CAD(4), CRAT(1), DARS(3), DDO(1), DLAT(1), DLD(2), GAD1(2), GAD2(2), GOT2(1), GPT(2), NARS2(1), PC(5)	16007712	38	33	38	4	2	6	3	14	12	1	0.0580	0.273	1.000
59	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(1), LPO(1), MPO(1), MTHFR(1), PRDX6(2), SHMT1(2), SHMT2(3)	4894459	11	11	11	2	1	0	3	4	3	0	0.463	0.277	1.000
60	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(4), EHHADH(1), HADHA(2)	3556745	7	7	7	1	0	0	1	5	1	0	0.510	0.278	1.000
61	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(1), LPO(1), MPO(1), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(3)	5006222	11	11	11	2	1	1	2	4	3	0	0.402	0.280	1.000
62	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	MAPK14(1), THBS1(5)	3033979	6	6	6	1	0	0	3	2	1	0	0.544	0.280	1.000
63	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(3), KARS(1)	1962369	4	4	4	1	0	1	1	2	0	0	0.622	0.282	1.000
64	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), CS(1), DLD(2), FH(2), IDH2(1), IDH3B(1), PC(5), PCK1(5), SDHA(1), SUCLA2(1), SUCLG1(1)	8691813	21	20	21	4	0	2	4	4	10	1	0.358	0.294	1.000
65	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD1(2), GAD2(2), GGT1(1)	2439448	7	7	7	2	0	1	2	2	2	0	0.647	0.295	1.000
66	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(4), CREB1(1), MAPK1(1), RAF1(3), SNX13(1), TERF2IP(1)	4794132	14	13	13	3	1	2	1	5	5	0	0.507	0.311	1.000
67	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1), TAT(1)	1111600	2	2	2	0	1	0	0	0	1	0	0.719	0.321	1.000
68	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(1), FTCD(1), GART(2), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(2), SHMT2(3)	8055369	20	20	20	4	1	3	5	7	4	0	0.258	0.325	1.000
69	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCL(2), HMGCS1(2), HMGCS2(2)	3208910	6	6	6	0	0	0	0	2	4	0	0.303	0.328	1.000
70	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(2), ELK1(1), GRB2(1), NGFR(1), PIK3CA(6), PIK3R1(2), RAF1(3), SOS1(2)	8022754	18	17	16	3	3	6	1	5	3	0	0.182	0.335	1.000
71	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(2), MTMR6(1), PHPT1(1), TPK1(1)	2672050	5	5	5	0	0	1	1	3	0	0	0.266	0.336	1.000
72	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(3), CBS(1), CTH(1), DNMT1(1), DNMT3A(5), DNMT3B(2), MARS(1), MAT1A(1), MAT2B(1), MTR(1)	7364714	20	19	20	4	1	2	1	5	11	0	0.496	0.337	1.000
73	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(1), JAK1(2), JAK2(1), STAT1(2)	3422146	8	8	8	2	1	0	0	5	2	0	0.789	0.349	1.000
74	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(1), ITGAM(3), ITGB2(1), SELE(1), SELL(1)	4416966	8	8	8	1	0	2	0	5	1	0	0.423	0.358	1.000
75	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH4A1(1), AMD1(2), AOC2(2), ARG1(1), ARG2(1), CKB(1), CPS1(1), GATM(1), GLUD1(1), GOT2(1), MAOA(1), MAOB(3), NOS1(1), NOS3(1), OAT(2), ODC1(1), P4HA1(1), P4HA3(1), RARS(2)	19064227	33	31	33	2	5	1	6	10	11	0	0.0136	0.364	1.000
76	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), MTHFD2(1), POLB(1), POLD1(2), POLG(2), PRPS2(1), RRM1(2)	5376760	10	10	10	1	0	1	1	4	4	0	0.274	0.364	1.000
77	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	EIF4A1(1), EIF4A2(3), EIF4G1(3), EIF4G2(1), EIF4G3(4), IRS1(2), MAPK1(1), MAPK14(1), PABPC1(1), PDK2(1), PIK3CA(6), PIK3R1(2), PRKCA(1)	11697189	27	24	25	4	4	6	2	8	7	0	0.163	0.371	1.000
78	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(2)	1649292	3	3	3	1	0	0	0	1	2	0	0.947	0.375	1.000
79	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(1), GFPT1(2), GNE(1), HEXA(1), HEXB(1), HK1(2), RENBP(3), UAP1(1)	7186249	13	12	13	1	0	2	3	7	1	0	0.130	0.375	1.000
80	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(3), PAPSS1(1), PAPSS2(2), SUOX(1)	3571801	7	6	7	0	0	1	1	2	3	0	0.261	0.375	1.000
81	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), RXRA(2)	2272079	4	4	4	1	0	2	0	1	1	0	0.662	0.375	1.000
82	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL4(1), ST6GALNAC2(1), ST6GALNAC4(1)	2380495	4	4	4	0	1	1	0	2	0	0	0.254	0.385	1.000
83	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA6(1), PSMA7(1), PSMB1(1), PSMB5(1), PSMC3(1), RPN1(2), RPN2(1), UBE3A(3)	5492992	11	11	11	2	1	1	1	6	2	0	0.489	0.385	1.000
84	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(2), RIPK1(1), TNF(1), TNFRSF1B(2)	3529516	6	6	6	1	0	1	1	3	1	0	0.608	0.385	1.000
85	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), KEAP1(2), MAPK1(1), MAPK14(1), PRKCA(1)	3294199	6	6	6	1	1	0	0	2	3	0	0.530	0.388	1.000
86	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ARG1(1), ARG2(1), CKB(1), CPS1(1), GATM(1), GLUD1(1), NAGS(1), OAT(2), ODC1(1)	7819835	13	13	13	1	0	0	2	5	6	0	0.336	0.395	1.000
87	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	636973	1	1	1	0	0	0	0	0	1	0	1.000	0.399	1.000
88	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADHA(2), HSD17B4(1), MECR(3)	3591561	6	6	6	1	1	1	0	4	0	0	0.520	0.409	1.000
89	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(2), GOT2(1), PAH(2), TAT(1), YARS2(1)	3669188	7	6	7	1	1	1	1	2	2	0	0.545	0.409	1.000
90	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(2), HDC(1), TPH1(1)	2532576	4	4	4	1	0	1	1	1	1	0	0.630	0.414	1.000
91	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(1), EGFR(1), ERBB3(2), NRG1(3)	4311395	7	7	7	1	0	1	1	3	2	0	0.330	0.415	1.000
92	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(3), ALOX12B(1), ALOX15B(2), ALOX5(2), CYP2C18(2), CYP2C8(1), CYP2J2(1), CYP4A11(2), CYP4F2(2), CYP4F3(3), DHRS4(1), EPHX2(1), GGT1(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PTGES(1), PTGS2(1), TBXAS1(1)	16819046	31	27	31	2	2	3	2	14	9	1	0.0627	0.420	1.000
93	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BAX(1), BCL10(1), BCL2L11(1), BID(1), CASP9(1), CES1(1)	4751872	8	8	8	1	0	2	1	2	3	0	0.420	0.429	1.000
94	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(3), CYP2A7(1), XDH(1)	3374553	7	7	7	2	0	1	0	5	1	0	0.783	0.431	1.000
95	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(3), ITPKA(1), ITPKB(1)	2545891	6	5	6	4	0	0	2	0	4	0	0.994	0.434	1.000
96	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(2), CES1(1), ESD(1)	2618986	4	4	4	1	0	2	1	1	0	0	0.517	0.440	1.000
97	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(3), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DOT1L(5), EHHADH(1), EHMT1(1), EHMT2(3), GCDH(2), HADHA(2), HSD17B4(1), NSD1(4), OGDH(5), OGDHL(1), PIPOX(3), PLOD1(1), PLOD2(3), PLOD3(1), RDH11(1), RDH12(3), RDH13(1), SETD1A(4), SETDB1(4), SHMT1(2), SHMT2(3), SPCS3(1), SUV39H1(1), SUV39H2(1)	24470018	64	53	64	9	5	10	7	25	16	1	0.0234	0.445	1.000
98	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ARG2(1), CKB(1), CPS1(1), EPRS(1), GATM(1), GLUD1(1), GOT2(1), LAP3(2), NOS1(1), NOS3(1), OAT(2), P4HA1(1), P4HA3(1), PARS2(1), PYCR2(2), PYCRL(2), RARS(2), RARS2(2)	15623692	26	24	26	1	1	2	5	8	10	0	0.0248	0.449	1.000
99	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	EHHADH(1), GCDH(2), HADHA(2)	3289306	5	5	5	1	1	1	1	2	0	0	0.456	0.451	1.000
100	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(1), AKT3(1), GRB2(1), IL4R(2), IRS1(2), IRS2(3), JAK1(2), JAK3(1), MAP4K1(1), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(2), PPP1R13B(2), RAF1(3), SOCS1(1), SOS1(2), SOS2(1)	15413510	33	30	31	4	4	8	3	12	6	0	0.0241	0.455	1.000
101	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), ELK1(1), GRB2(1), IL2(1), JAK1(2), JAK3(1), RAF1(3), SOS1(2), STAT5A(2), STAT5B(1)	9976485	16	15	16	0	2	2	2	5	5	0	0.0180	0.459	1.000
102	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(2), EPHB1(1), ITGA1(3), ITGB1(1), LYN(3)	6558287	11	10	11	1	1	1	0	5	4	0	0.400	0.460	1.000
103	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), SELL(1), TNF(1), TNFRSF1B(2), TNFRSF8(1), TNFSF8(2)	5743595	11	9	11	1	0	2	2	5	2	0	0.281	0.468	1.000
104	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(4), ACADM(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH6A1(1), BCKDHA(1), DBT(1), DLD(2), EHHADH(1), HADHA(2), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), MCCC1(1), MCCC2(1), PCCA(1), PCCB(1)	18437493	33	31	33	3	2	2	5	15	8	1	0.0452	0.483	1.000
105	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(2), CYP1A2(2), CYP2C18(2), CYP2C8(1), CYP2J2(1), CYP3A43(2), CYP3A7(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), RDH11(1), RDH12(3), RDH13(1)	10225652	20	18	20	2	0	4	0	10	5	1	0.206	0.487	1.000
106	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), IFNG(2), IFNGR1(1), IL12RB2(1), IL18(1), IL2(1), IL4R(2)	5304213	10	10	10	2	0	0	1	4	5	0	0.684	0.491	1.000
107	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(1), ALPI(1), ALPL(1), ALPPL2(1), CMBL(3), CYP3A43(2), CYP3A7(1), PON1(1), PON2(2)	7725604	13	13	13	2	1	2	0	4	6	0	0.578	0.496	1.000
108	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO2(1), GOT2(1), PAH(2), TAT(1)	3488541	6	5	6	1	1	1	1	1	2	0	0.543	0.499	1.000
109	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(2), BMPR2(1)	2624596	4	4	4	0	0	1	0	2	1	0	0.280	0.505	1.000
110	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP17A1(1), HSD11B1(1)	2913236	4	4	4	1	1	0	0	2	1	0	0.682	0.509	1.000
111	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(2), PTPRU(2), STAT1(2), STAT2(1)	5274834	8	8	8	1	1	0	0	4	3	0	0.291	0.514	1.000
112	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	708436	1	1	1	0	0	0	0	1	0	0	0.838	0.526	1.000
113	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), ENPP1(2), ENPP3(1), FLAD1(2)	4080194	6	6	6	0	0	1	0	3	2	0	0.375	0.531	1.000
114	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDK4(1), MAPK1(1), NFKBIA(1), PAK1(2), PIK3CA(6), PIK3R1(2), RAF1(3), RELA(2)	8506020	18	16	16	3	2	4	2	5	5	0	0.341	0.543	1.000
115	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(1), GALNT2(1), GALNT4(2), GALNT6(3), GALNT7(3), ST3GAL4(1)	6190496	11	11	11	2	0	1	0	6	4	0	0.518	0.544	1.000
116	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1), SPCS3(1)	1311142	2	2	2	0	0	0	0	1	1	0	0.833	0.551	1.000
117	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), PTGS2(1)	2228210	3	3	3	0	0	1	0	2	0	0	0.397	0.555	1.000
118	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(2), C5(1), C6(2), C7(1), C8A(2), C9(1)	5263556	9	9	9	2	0	3	1	5	0	0	0.490	0.558	1.000
119	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFLAR(2)	1616937	2	2	2	0	0	0	1	1	0	0	0.622	0.559	1.000
120	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	BPNT1(3), CHST13(1), PAPSS1(1), PAPSS2(2), SUOX(1)	4897485	8	7	8	0	0	1	2	2	3	0	0.195	0.561	1.000
121	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT2(1), B4GALT5(1), ST3GAL4(1)	3277078	6	5	6	1	0	0	0	3	3	0	0.862	0.572	1.000
122	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(1), ENPP1(2), ENPP3(1), FLAD1(2), MTMR2(2), MTMR6(1), PHPT1(1)	6327633	10	9	10	0	0	2	1	5	2	0	0.120	0.575	1.000
123	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(5), GCLC(3), GCLM(1), GGT1(1), GSTA1(2), GSTA2(1), GSTM1(1), GSTM4(1), GSTT1(1), IDH2(1), PGD(1)	8079424	18	15	18	3	0	0	9	7	2	0	0.191	0.576	1.000
124	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(1), CTH(1)	2066227	3	3	3	1	0	0	0	1	2	0	0.880	0.581	1.000
125	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(2), STAT1(2), STAT2(1)	4583583	6	6	6	1	1	0	0	2	3	0	0.395	0.586	1.000
126	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(3), ALOX5(2), CYP4F2(2), CYP4F3(3), GGT1(1), LPO(1), MPO(1), PLA2G4A(1), PLA2G6(2), PRDX5(1), PRDX6(2), PTGS2(1), TBXAS1(1)	11962719	23	21	23	3	1	2	2	12	6	0	0.222	0.588	1.000
127	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(1), IL4R(2), IRS1(2), JAK1(2), JAK3(1)	6214245	8	8	8	1	2	0	2	3	1	0	0.336	0.588	1.000
128	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(2)	1426382	2	2	2	0	0	0	0	1	1	0	0.524	0.589	1.000
129	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	KERA(2)	1492159	2	2	2	0	0	0	0	1	1	0	0.462	0.592	1.000
130	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	698255	1	1	1	0	0	0	0	1	0	0	0.819	0.594	1.000
131	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(1), CA1(1), CA12(1), CA14(1), CA6(1), CPS1(1), CTH(1), GLS(5), GLUD1(1), GLUL(2)	7964104	16	16	16	3	0	1	4	6	5	0	0.482	0.603	1.000
132	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CMAS(1), GFPT1(2), GFPT2(2), GNE(1), GNPNAT1(1), HEXA(1), HEXB(1), HK1(2), MTMR2(2), MTMR6(1), NAGK(1), NANS(1), NPL(1), PHPT1(1), RENBP(3), UAP1(1)	12120719	23	22	23	3	0	3	7	12	1	0	0.0943	0.606	1.000
133	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD33(1), CD5(1), CD7(2), IFNG(2), ITGAX(6), TLR2(1), TLR7(1)	7809328	19	16	19	4	2	2	5	4	6	0	0.193	0.608	1.000
134	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA6(1), PSMA7(1), PSMB1(1), PSMB10(1), PSMB5(1)	3696156	5	5	5	1	0	0	0	4	1	0	0.724	0.608	1.000
135	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(2), KHK(2), LCT(1), MPI(1), PGM1(1), PYGM(1)	5719237	8	8	8	1	0	1	1	3	3	0	0.496	0.609	1.000
136	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), HLA-A(1), ICAM1(1), ITGAL(1), ITGB2(1)	3651810	5	5	5	1	0	1	0	3	1	0	0.683	0.612	1.000
137	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	CFLAR(2), GRB2(1), IRS1(2), JAK1(2), JAK3(1), MAPK1(1), PIK3CA(6), PIK3R1(2), PPIA(1), RAF1(3), SOCS1(1), SOCS3(1), SOS1(2), STAT5A(2), STAT5B(1)	15280907	28	24	26	3	4	6	3	9	6	0	0.0418	0.617	1.000
138	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	HMGB1(2), HMGB2(2), TOP2A(1), TOP2B(1)	4099910	6	5	6	1	1	1	1	1	2	0	0.570	0.620	1.000
139	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), HEXA(1), HEXB(1), LCT(1), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA5(2)	6938159	10	9	10	0	0	3	0	5	2	0	0.0686	0.620	1.000
140	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), JUNB(1), MAP2K3(1), MAPK14(1), NFATC2(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2)	5164669	9	8	9	2	0	1	2	3	3	0	0.563	0.623	1.000
141	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), MAP2K2(1), MAPK1(1), NGFR(1), RAF1(3)	3505685	7	7	7	2	2	0	0	4	1	0	0.671	0.623	1.000
142	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(2), PRKCA(1)	2113467	3	3	3	0	0	0	0	0	3	0	1.000	0.627	1.000
143	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BAX(1), BID(1), BIK(1), BIRC2(1), BIRC3(2), CASP6(1), CASP9(1)	5685902	10	10	10	2	0	1	1	6	2	0	0.575	0.636	1.000
144	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(4), NR3C1(2), PPARG(1), RXRA(2), TNF(1)	2421261	11	10	11	4	1	4	0	2	4	0	0.784	0.638	1.000
145	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMKK1(3), CREB1(1)	4946231	11	11	11	3	2	1	2	3	3	0	0.534	0.638	1.000
146	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(2), DHCR24(1), GGCX(1), HMGCR(1), IDI2(1), LSS(2), TM7SF2(2)	8159862	11	11	11	1	1	1	1	6	2	0	0.229	0.638	1.000
147	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25C(1), GRB2(1), PRKCA(1), PTPRA(1)	3934790	5	5	5	1	1	1	0	2	1	0	0.550	0.639	1.000
148	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT2(1), TAT(1)	1976215	2	2	2	1	1	0	0	0	1	0	0.915	0.640	1.000
149	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(1), PTK2B(1), SOS1(2)	3684463	5	5	5	0	0	1	0	2	2	0	0.191	0.642	1.000
150	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(4), ACADL(3), ACADM(2), ACADSB(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH6A1(1), BCKDHA(1), EHHADH(1), HADHA(2), HMGCL(2), MCCC1(1), MCCC2(1), PCCA(1), PCCB(1)	15234550	28	27	28	4	2	3	6	12	5	0	0.116	0.651	1.000
151	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	IFNG(2), IL2(1), TGFBR1(1), TOB1(2)	4487039	6	6	6	1	0	0	1	4	1	0	0.545	0.655	1.000
152	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), HMGCR(1), HMGCS1(2), LSS(2)	5531951	7	7	7	1	0	1	1	3	2	0	0.456	0.659	1.000
153	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(1), IGF1R(2), IRS1(2), MAPK1(1), PIK3CA(6), PIK3R1(2), RAF1(3), SOS1(2)	7931845	19	17	17	4	3	5	0	7	4	0	0.306	0.660	1.000
154	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2)	1344997	2	1	2	0	0	1	0	1	0	0	0.470	0.669	1.000
155	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	RECK(2), TIMP1(1), TIMP2(1)	3222203	4	4	4	1	0	0	0	3	1	0	0.875	0.679	1.000
156	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(1), ALPPL2(1), FPGS(1), GGH(1)	2929678	5	5	5	2	1	2	0	0	2	0	0.761	0.679	1.000
157	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1)	1245173	1	1	1	0	0	0	1	0	0	0	0.746	0.680	1.000
158	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2I(1), UBE2L3(1), UBE3A(3)	4426773	5	5	5	1	1	0	1	3	0	0	0.607	0.680	1.000
159	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(3), AXIN1(3), BTRC(2), CTNNB1(2), FZD1(1), NOTCH1(2), PSEN1(1)	9100119	17	17	17	3	1	2	0	12	2	0	0.313	0.682	1.000
160	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH6(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3)	5595886	9	9	9	2	2	0	2	4	1	0	0.470	0.685	1.000
161	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CBS(1), CTH(1), GGT1(1), MARS(1), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), SCLY(1)	10556326	21	18	21	3	0	3	4	7	7	0	0.270	0.685	1.000
162	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(2), BHMT(3), CBS(1), CTH(1), DNMT1(1), DNMT3A(5), DNMT3B(2), MARS(1), MAT1A(1), MAT2B(1), MTR(1), TAT(1)	8773642	23	22	23	6	3	2	2	5	11	0	0.620	0.686	1.000
163	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(2), F2R(1), F5(3), PROS1(1)	6902048	8	8	8	1	2	0	1	3	2	0	0.452	0.686	1.000
164	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), GCNT2(2)	2588553	3	3	3	0	0	0	0	2	1	0	0.576	0.687	1.000
165	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLD2(1), POLE(1), POLG(2), POLL(1), POLQ(3)	7087152	11	11	11	2	0	3	2	3	3	0	0.349	0.692	1.000
166	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), FH(2), IDH2(1), SUCLA2(1)	3759767	5	5	5	2	0	0	0	1	4	0	0.807	0.692	1.000
167	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYC(1), SP3(1)	2821383	5	5	5	2	0	2	1	2	0	0	0.724	0.693	1.000
168	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(3), AASS(3), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DOT1L(5), EHHADH(1), EHMT1(1), EHMT2(3), GCDH(2), HADHA(2), PLOD1(1), PLOD2(3), PLOD3(1), SHMT1(2), SHMT2(3)	15586489	37	31	37	5	5	6	6	13	7	0	0.0205	0.695	1.000
169	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLB(1), POLD1(2), POLD2(1), POLE(1), POLG(2), POLG2(1), POLI(1), POLK(2), POLL(1), POLM(3), POLQ(3), REV1(2), REV3L(3), RFC5(1)	17221311	26	25	26	2	0	5	3	12	6	0	0.0536	0.708	1.000
170	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKBIA(1), PLCB1(1), PRKCA(1), RELA(2)	3458019	5	5	5	3	0	0	0	1	4	0	0.991	0.708	1.000
171	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), EHHADH(1), ESCO1(2), HADHA(2), PNPLA3(1), YOD1(1)	12981038	16	16	16	1	2	2	3	5	4	0	0.0835	0.711	1.000
172	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), GRB2(1), JAK2(1), RAF1(3), SOS1(2), STAT5A(2), STAT5B(1)	7548306	13	12	13	2	0	1	1	6	5	0	0.485	0.721	1.000
173	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PRKCA(1), PTK2B(1)	2832700	3	3	3	0	1	0	0	1	1	0	0.584	0.721	1.000
174	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(1)	1552318	1	1	1	0	0	0	0	0	1	0	0.830	0.723	1.000
175	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	ENPP1(2), ENPP3(1), NMNAT2(1), NNT(3), NT5C(1), NT5M(1)	6144505	9	9	9	2	1	2	0	5	1	0	0.554	0.724	1.000
176	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFB4(2), NDUFB5(1), NDUFB7(1), NDUFS1(1), NDUFV1(1)	2949207	6	6	6	3	0	0	1	2	3	0	0.925	0.733	1.000
177	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(1), COPS5(1), CREB1(1), EP300(5), HIF1A(2), NOS3(1), VHL(3)	7130600	14	12	14	5	1	0	1	4	7	1	0.943	0.740	1.000
178	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(2), EXTL1(1), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), NDST1(1), NDST4(2)	8879971	13	13	13	2	1	5	1	2	4	0	0.208	0.744	1.000
179	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), IL5RA(1)	2227903	2	2	2	0	0	0	1	0	1	0	0.734	0.744	1.000
180	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CTH(1), GOT2(1), SULT1B1(1), SULT1C4(4)	5300168	7	7	7	2	0	1	3	1	2	0	0.680	0.745	1.000
181	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	LARS(4)	4183403	4	4	4	1	1	0	1	0	2	0	0.766	0.746	1.000
182	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(1), IGF1R(2), PIK3CA(6), PIK3R1(2)	5551174	11	10	9	3	1	4	0	4	2	0	0.635	0.754	1.000
183	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CHEK1(1), NEK1(1)	3063667	3	3	3	0	1	0	0	2	0	0	0.532	0.754	1.000
184	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(1), ACSS1(1), ACSS2(1), FH(2), IDH2(1), SUCLA2(1)	5614980	10	9	10	5	1	0	0	3	6	0	0.937	0.754	1.000
185	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), XYLT1(1)	2942367	5	5	5	2	2	0	0	2	1	0	0.760	0.754	1.000
186	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), XYLT1(1)	2942367	5	5	5	2	2	0	0	2	1	0	0.760	0.754	1.000
187	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT1(2), B4GALT2(1), B4GALT5(1), DPAGT1(2), MAN1B1(1), MGAT4B(1), MGAT5(1), RPN1(2), RPN2(1), ST6GAL1(1)	8449245	13	12	13	2	0	3	0	3	7	0	0.521	0.758	1.000
188	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACADM(2), CPT1A(1), EHHADH(1), HADHA(2), SCP2(1)	7084853	10	10	10	2	0	3	3	4	0	0	0.310	0.759	1.000
189	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS2(4), ILVBL(3), LARS(4), VARS(1), VARS2(3)	7792424	15	14	15	3	2	0	5	4	4	0	0.519	0.759	1.000
190	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), HDC(1), MAOA(1), MAOB(3), PRPS2(1)	10296754	15	14	15	2	3	2	2	6	2	0	0.158	0.760	1.000
191	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), ALPI(1), ALPL(1), ALPPL2(1), CYP1A2(2), CYP2A13(3), CYP2A7(1), CYP2C18(2), CYP2C8(1), CYP2D6(1), CYP2F1(1), CYP2J2(1), CYP3A7(1), CYP51A1(2), PON1(1)	12447440	20	18	20	3	2	3	0	9	5	1	0.383	0.763	1.000
192	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(1), GALNT10(1), GALNT11(1), GALNT2(1), GALNT4(2), GALNT5(1), GALNT6(3), GALNT7(3), GCNT3(2), OGT(2)	13649419	19	18	19	2	1	2	3	7	6	0	0.135	0.765	1.000
193	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	RPE(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2)	7392982	15	15	15	4	0	2	6	4	3	0	0.554	0.765	1.000
194	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(5), GCLC(3), GCLM(1), GGT1(1), GSR(1), GSTA1(2), GSTA2(1), GSTK1(2), GSTM1(1), GSTM4(1), GSTT1(1), IDH2(1), TXNDC12(1)	9769147	21	17	21	4	0	1	9	9	2	0	0.184	0.766	1.000
195	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UGDH(1)	1656194	1	1	1	1	0	0	1	0	0	0	0.910	0.766	1.000
196	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	IDI2(1)	1797382	1	1	1	1	1	0	0	0	0	0	0.889	0.767	1.000
197	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(1), ITGAL(1), ITGAM(3), ITGB1(1), ITGB2(1), SELE(1), SELL(1)	6715243	10	10	10	2	0	2	1	5	2	0	0.566	0.771	1.000
198	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	ENPP1(2), ENPP3(1), NADK(1), NMNAT2(1), NNT(3), NT5C(1), NT5C1A(1), NT5C1B(1), NT5M(1)	9058758	12	12	12	2	2	2	0	7	1	0	0.373	0.771	1.000
199	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), GBGT1(1), HEXA(1), HEXB(1), ST3GAL4(1)	4227049	5	5	5	0	0	0	0	4	1	0	0.479	0.775	1.000
200	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(1), AMT(1), AOC2(2), BHMT(3), CBS(1), CHDH(1), CPT1B(1), CTH(1), DLD(2), GATM(1), MAOA(1), MAOB(3), PLCB2(3), PLCG2(1), SHMT1(2), SHMT2(3), TARS(1)	17905481	29	29	29	4	3	3	6	9	7	1	0.123	0.778	1.000
201	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(2), HSPA1A(1), IFNG(2), IFNGR1(1), IKBKB(1), JAK2(1), NFKBIA(1), RELA(2), TNF(1), TNFRSF1B(2), USH1C(1)	7744252	15	14	15	3	0	1	0	7	7	0	0.751	0.793	1.000
202	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), JAK1(2), JAK2(1), JAK3(1), PIAS3(1), PTPRU(2), STAT3(1)	6484112	10	9	10	2	1	2	1	5	1	0	0.488	0.796	1.000
203	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(1), CDC25C(1), SHH(1), XPO1(2)	3701017	5	5	5	2	2	1	2	0	0	0	0.587	0.796	1.000
204	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(1), ITGAL(1), ITGB1(1), ITGB2(1), SELE(1), SELL(1)	5088470	7	7	7	2	0	2	1	2	2	0	0.728	0.799	1.000
205	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), AKT3(1), ELK1(1), GRB2(1), MAP2K2(1), NGFR(1), NTRK1(1), PIK3CA(6), PIK3CD(1), SOS1(2)	6877524	16	15	14	4	2	6	0	5	3	0	0.189	0.808	1.000
206	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT5(1), FUT6(1)	2144272	2	2	2	0	0	1	0	1	0	0	0.446	0.809	1.000
207	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNB1(1), PLCB1(1), TUB(1)	2975997	5	4	5	2	0	1	0	3	1	0	0.807	0.810	1.000
208	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(1), DLAT(1), DLD(2), FH(2), IDH2(1), IDH3B(1), OGDH(5), PC(5), PDK2(1), PDK4(2), SDHA(1), SDHD(1), SUCLA2(1), SUCLG1(1)	11993651	25	23	25	5	0	2	4	6	12	1	0.373	0.816	1.000
209	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(2), FBXW7(1)	3513457	3	3	3	0	1	0	0	1	1	0	0.569	0.816	1.000
210	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(1), CLYBL(1), CS(1), DLD(2), FH(2), IDH2(1), IDH3B(1), OGDH(5), OGDHL(1), PC(5), PCK1(5), PCK2(1), SDHA(1), SDHD(1), SUCLA2(1), SUCLG1(1)	12557410	33	29	33	7	2	3	5	9	13	1	0.356	0.818	1.000
211	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	IL2(1), IL9(1)	2606000	2	2	2	0	0	0	1	1	0	0	0.613	0.818	1.000
212	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), GBGT1(1), HEXA(1), HEXB(1)	4477720	5	5	5	0	0	0	0	4	1	0	0.486	0.818	1.000
213	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(1), CA1(1), CA12(1), CA13(2), CA14(1), CA6(1), CPS1(1), CTH(1), GLS(5), GLUD1(1), GLUL(2)	8897092	18	18	18	4	0	2	4	7	5	0	0.544	0.820	1.000
214	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(4), ABCG2(1), CES1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2)	9684980	22	22	22	5	1	4	7	6	4	0	0.352	0.824	1.000
215	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREB1(1), CREBBP(8), EP300(5), NCOA3(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), RXRA(2)	8710774	22	22	22	8	0	5	4	3	10	0	0.771	0.825	1.000
216	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), JAK1(2), JAK2(1), JAK3(1), SOCS3(1), STAT1(2), STAT3(1), STAT5A(2), STAT5B(1)	7923615	14	14	14	3	2	1	2	5	4	0	0.628	0.828	1.000
217	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNG(2), IL16(1), IL18(1), IL2(1), IL9(1), TNF(1)	4170267	7	6	7	2	0	0	1	3	3	0	0.858	0.832	1.000
218	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	RDH5(1)	1610580	1	1	1	0	0	0	0	1	0	0	0.829	0.832	1.000
219	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA6(1), PSMA7(1), PSMB1(1), PSMB5(1), PSMC2(2), PSMC3(1), PSMD1(2), PSMD12(1), PSMD13(1), PSMD2(3), PSMD6(1)	6742547	15	14	15	4	0	0	1	9	5	0	0.819	0.833	1.000
220	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), CS(1), HAO1(2), HAO2(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	5364802	10	10	10	3	1	1	2	3	3	0	0.713	0.835	1.000
221	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CSF1R(3), EGF(1), EGFR(1), GRB2(1), PDGFRA(1), PRKCA(1), SH3KBP1(2)	6990697	10	9	10	2	2	1	1	4	2	0	0.512	0.836	1.000
222	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), NOX1(1), RELA(2), TNF(1), XDH(1)	4208926	6	6	6	2	0	0	2	0	4	0	0.947	0.838	1.000
223	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CUL1(2), SKP2(1)	3618986	3	3	3	0	1	0	0	2	0	0	0.480	0.841	1.000
224	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CUL1(2), SKP2(1)	3631878	3	3	3	0	1	0	0	2	0	0	0.473	0.841	1.000
225	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	HMGCR(1), LSS(2), NQO2(1)	4646807	4	4	4	1	0	1	2	0	1	0	0.529	0.843	1.000
226	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), EHHADH(1), GAD1(2), GAD2(2), HADHA(2), HMGCL(2)	10912064	17	17	17	3	2	1	3	7	4	0	0.247	0.845	1.000
227	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	IL2(1)	1657614	1	1	1	0	0	0	0	1	0	0	0.836	0.847	1.000
228	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(5), CDC25A(1), CDC25C(1), CHEK1(1), MYT1(6)	5824087	14	13	14	4	1	6	2	3	2	0	0.430	0.848	1.000
229	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(1), BIRC3(2), CASP10(1), CASP9(1), SCAP(1), SREBF1(2), SREBF2(5)	7841016	15	14	15	3	1	1	2	6	5	0	0.428	0.849	1.000
230	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1)	1364155	1	1	1	0	0	0	0	1	0	0	0.834	0.849	1.000
231	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(4), ADH6(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), BAAT(1), CEL(1), CYP27A1(1), CYP7A1(1), SRD5A1(1)	9808640	18	18	18	4	2	0	2	11	3	0	0.518	0.849	1.000
232	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC2(2), CES1(1), DDHD1(1), ESCO1(2), LIPA(1), PLA1A(1), PNPLA3(1), PRDX6(2)	10690549	11	11	11	0	0	4	1	4	2	0	0.0570	0.852	1.000
233	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), NOTCH1(2), PSEN1(1)	4010060	6	6	6	2	0	1	0	4	1	0	0.729	0.853	1.000
234	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UGDH(1)	2093168	1	1	1	1	0	0	1	0	0	0	0.902	0.858	1.000
235	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	AGT(3), AGTR2(1), CMA1(1), COL4A1(2), COL4A2(3), COL4A3(2), COL4A5(1), COL4A6(2)	10719413	15	15	15	3	1	5	0	6	3	0	0.424	0.864	1.000
236	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), CS(1), HAO1(2), HAO2(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	5626210	10	10	10	3	1	1	2	3	3	0	0.717	0.865	1.000
237	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	COMT(1), GAD1(2), GAD2(2), HDC(1), MAOA(1), PAH(2), SLC18A3(1), TPH1(1)	6051726	11	10	11	3	0	2	2	5	2	0	0.578	0.865	1.000
238	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLRMT(2)	5690160	11	11	11	4	0	0	1	5	5	0	0.892	0.866	1.000
239	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(2), JAK2(1), JAK3(1), PIAS1(1), PIAS3(1), PTPRU(2), SOAT1(1)	5844477	11	10	11	3	1	1	2	6	1	0	0.661	0.874	1.000
240	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	PSAT1(1)	2026272	1	1	1	1	0	0	0	0	1	0	1.000	0.874	1.000
241	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(2), ATM(5), BAX(1), CDK4(1)	7242781	9	9	9	2	0	1	2	2	4	0	0.602	0.876	1.000
242	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B4GALT1(2), B4GALT2(1), CHST2(3), ST3GAL4(1)	5162524	9	7	9	2	0	1	0	2	6	0	0.870	0.877	1.000
243	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(2), ABCB11(1), ABCB4(2), ABCC1(3), ABCC3(2)	6032348	10	10	10	3	1	4	1	3	1	0	0.475	0.879	1.000
244	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(3), CALCRL(2), CD97(3), CRHR2(1), ELTD1(2), GIPR(1), GLP2R(2), LPHN1(2), LPHN2(1), LPHN3(2)	11479233	19	19	18	4	0	2	4	8	4	1	0.406	0.881	1.000
245	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(2), EHHADH(1), ESCO1(2), GCDH(2), HADHA(2), PNPLA3(1), YOD1(1)	10884336	11	11	11	1	1	3	1	3	3	0	0.225	0.881	1.000
246	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	METTL2B(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2)	6314317	8	6	8	1	0	0	2	3	3	0	0.419	0.883	1.000
247	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(4), ACAD8(1), ACAD9(1), ADH6(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), BAAT(1), CEL(1), CYP27A1(1), CYP7A1(1), LIPA(1), RDH11(1), RDH12(3), RDH13(1), SOAT1(1), SRD5A1(1)	13438700	27	27	27	5	2	2	2	17	4	0	0.325	0.884	1.000
248	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	PCYT1A(1), SLC18A3(1)	2907571	2	2	2	1	1	0	0	1	0	0	0.775	0.885	1.000
249	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(8), EP300(5), MAPK1(1)	6317038	14	14	14	7	1	2	3	2	6	0	0.933	0.888	1.000
250	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(1), LRP8(2), RELN(3), VLDLR(1)	5847438	7	7	7	2	0	2	1	3	1	0	0.685	0.891	1.000
251	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT2(1)	2860139	2	2	2	1	0	0	0	1	1	0	0.952	0.895	1.000
252	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(2), ELK1(1), GRB2(1), IL6ST(2), JAK1(2), JAK2(1), JAK3(1), RAF1(3), SOS1(2), STAT3(1)	10106356	16	15	16	3	2	3	2	7	2	0	0.280	0.896	1.000
253	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(1), JAK3(1), MAPK1(1), STAT3(1)	5018977	6	6	6	2	2	1	1	2	0	0	0.675	0.896	1.000
254	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC1(1)	3098032	4	4	4	2	0	0	3	1	0	0	0.830	0.898	1.000
255	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), ELK1(1), GRB2(1), JAK2(1), RAF1(3), SOS1(2), STAT5A(2), STAT5B(1)	9205902	13	11	13	2	1	2	1	4	5	0	0.379	0.900	1.000
256	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), HK1(2), PFKL(1)	3851963	6	6	6	3	1	1	0	1	3	0	0.864	0.900	1.000
257	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(1), CASP10(1), CASP9(1)	5341862	5	5	5	0	0	1	0	0	4	0	0.552	0.902	1.000
258	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGEF2(4), CLTA(2), CLTB(1), GBF1(8), GPLD1(1), KDELR3(3)	6840426	20	19	20	7	1	1	4	8	6	0	0.759	0.907	1.000
259	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACMSD(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), CAT(1), CYP1A2(2), CYP2A13(3), CYP2A7(1), CYP2C18(2), CYP2C8(1), CYP2D6(1), CYP2F1(1), CYP2J2(1), CYP3A7(1), CYP51A1(2), EHHADH(1), GCDH(2), HAAO(1), HADHA(2), KYNU(1), MAOA(1), MAOB(3), TDO2(1), TPH1(1)	23132971	40	35	40	5	6	3	4	19	7	1	0.0628	0.911	1.000
260	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(2), ELK1(1), GRB2(1), LYN(3), MAP3K1(3), MAPK1(1), PAPPA(4), RPS6KA3(1), SOS1(2), VAV1(3), VAV3(1)	13492461	23	21	23	4	2	4	1	14	2	0	0.221	0.912	1.000
261	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	METTL2B(1), PCYT1A(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2)	5902006	9	7	9	2	1	0	2	3	3	0	0.515	0.915	1.000
262	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(2), F2R(1)	5606927	6	6	6	2	2	0	1	2	1	0	0.770	0.918	1.000
263	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	LPO(1), MPO(1), PRDX5(1), PRDX6(2)	4095748	5	5	5	2	0	1	1	1	2	0	0.825	0.923	1.000
264	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACMSD(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), CAT(1), CYP1A2(2), CYP1B1(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(2), HSD17B4(1), INMT(1), KYNU(1), LNX1(2), MAOA(1), MAOB(3), METTL2B(1), NFX1(3), OGDH(5), OGDHL(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), TDO2(1), TPH1(1), TPH2(1)	25475869	50	42	50	8	5	7	7	22	9	0	0.0539	0.927	1.000
265	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(1), AMT(1), AOC2(2), BHMT(3), CBS(1), CHDH(1), CTH(1), DLD(2), GATM(1), MAOA(1), MAOB(3), PIPOX(3), PSAT1(1), RDH11(1), RDH12(3), RDH13(1), SHMT1(2), SHMT2(3), TARS(1)	18194804	33	32	33	5	2	4	4	13	9	1	0.171	0.928	1.000
266	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1), IL9(1)	3562906	2	2	2	1	0	0	1	1	0	0	0.901	0.932	1.000
267	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD58(1)	2631811	1	1	1	0	0	0	1	0	0	0	0.709	0.933	1.000
268	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGAL(1), ITGB2(1), PTPRC(1), THY1(1)	4462002	5	5	5	2	0	1	0	2	2	0	0.904	0.936	1.000
269	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), ITPKA(1), PDE1B(1), PLCB1(1), PLCB2(3)	4671953	8	8	8	4	1	0	1	3	3	0	0.913	0.937	1.000
270	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), RELA(2), TNFRSF11A(2)	4625022	5	5	5	4	0	0	1	1	3	0	0.978	0.939	1.000
271	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	LPO(1), MPO(1), PRDX6(2)	3552250	4	4	4	2	0	0	1	1	2	0	0.931	0.941	1.000
272	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(5), CDC25A(1), CDC25C(1), CDK4(1), CHEK1(1), MYT1(6)	7091381	15	14	15	4	1	6	3	3	2	0	0.366	0.942	1.000
273	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA2(1), CCNE2(1), CDK4(1), CDKN2A(1), E2F2(1)	3752358	5	5	5	3	0	1	1	1	2	0	0.843	0.944	1.000
274	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	ABAT(1), ACSM1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DDHD1(1), EHHADH(1), GAD1(2), GAD2(2), HADHA(2), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), ILVBL(3), PLA1A(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(1)	17360886	35	34	35	6	2	3	5	16	9	0	0.171	0.946	1.000
275	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(1), ELK1(1), GNB1(1), GRB2(1), IGF1R(2), ITGB1(1), MAP2K2(1), MAPK1(1), MKNK2(1), NGFR(1), PDGFRA(1), PTPRR(3), RAF1(3), RPS6KA5(1), SOS1(2), STAT3(1)	14106066	22	21	22	4	3	7	1	6	5	0	0.174	0.946	1.000
276	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(6), PIK3R1(2), PLCB1(1), PRKCA(1), VAV1(3)	5403064	13	12	11	4	2	5	0	3	3	0	0.615	0.947	1.000
277	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGAL(1), ITGB2(1), PTPRC(1), THY1(1)	4691866	5	5	5	2	0	1	0	2	2	0	0.905	0.948	1.000
278	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), FBL(1), GPT(2), MAPK14(1), NCL(2)	3756147	11	10	11	5	0	0	4	5	2	0	0.804	0.950	1.000
279	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(4), CREB1(1), DUSP6(2), EEF2K(1), GRB2(1), MAP2K2(1), MAP3K8(1), MAPK1(1), MKNK2(1), RPS6KA3(1), SOS1(2), SOS2(1)	12556673	17	17	16	3	1	4	2	5	5	0	0.179	0.952	1.000
280	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(1), AOC2(2), GOT2(1), HPD(1), LPO(1), MAOA(1), MAOB(3), MPO(1), PRDX5(1), PRDX6(2), TAT(1)	9321186	15	15	15	4	2	2	2	4	5	0	0.570	0.953	1.000
281	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), RPL10A(2), RPL11(1), RPL13(1), RPL18A(1), RPL24(1), RPL26(1), RPL28(1), RPL3(1), RPL35(1), RPL36A(1), RPL37A(1), RPL3L(1), RPL6(1), RPS16(1), RPS2(1), RPS20(1), RPS8(1), RPSA(1)	9174315	20	20	20	5	2	1	1	8	8	0	0.730	0.953	1.000
282	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(1), CYP17A1(1), HSD11B1(1)	3795312	4	4	4	2	1	0	0	1	2	0	0.839	0.954	1.000
283	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(1), CYP17A1(1), HSD11B1(1)	3795312	4	4	4	2	1	0	0	1	2	0	0.839	0.954	1.000
284	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAPK1(1), NFKBIA(1), PLCB1(1), PRKCA(1), RAF1(3), RELA(2), TNF(1)	6483453	10	9	10	3	1	0	0	3	6	0	0.918	0.954	1.000
285	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	TNF(1)	2749234	1	1	1	0	0	0	0	0	1	0	1.000	0.955	1.000
286	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF3(1), CDK4(1), CDKN2A(1), E2F2(1), NXT1(1)	3137038	5	5	5	3	0	0	1	3	1	0	0.898	0.956	1.000
287	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(1), NTRK1(1), PIK3CA(6), PIK3R1(2), PRKCA(1), SOS1(2)	6549249	13	12	11	4	1	5	0	3	4	0	0.509	0.958	1.000
288	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	NFKBIA(1), RELA(2)	3817418	3	3	3	2	0	0	0	1	2	0	0.983	0.959	1.000
289	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), DNMT1(1), PTGDR(1), PTGFR(2)	4761797	5	4	5	2	0	0	2	2	1	0	0.833	0.959	1.000
290	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	AGT(3), AGTR2(1), EGF(1), EGFR(1), PRKCA(1), RELA(2)	8592363	9	9	9	2	1	0	1	3	4	0	0.665	0.963	1.000
291	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT3(1), CHST13(1), CHST3(1), CHSY1(1), XYLT1(1)	5998351	6	6	6	2	1	1	1	2	1	0	0.721	0.965	1.000
292	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	IFNG(2), IL2(1), TNF(1)	5687118	4	4	4	1	0	0	0	2	2	0	0.873	0.966	1.000
293	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	HIF1A(2), JAK2(1), NFKBIA(1), RELA(2)	5418738	6	5	6	4	0	0	1	2	2	1	0.993	0.967	1.000
294	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	EGF(1), EGFR(1), GRB2(1), MAPK1(1), PTPRB(4), RAF1(3), RASA1(2), SOS1(2), SPRY1(1), SPRY2(1)	10508049	17	17	17	4	1	2	3	7	4	0	0.416	0.967	1.000
295	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CREBBP(8), EP300(5), IKBKB(1), NFKBIA(1), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(2)	9688449	21	20	21	6	0	3	4	5	9	0	0.759	0.968	1.000
296	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(2), PGM1(1)	4351106	4	4	4	2	0	1	0	2	1	0	0.873	0.968	1.000
297	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(2), CASP9(1), DAXX(1), FASLG(2), HSPB2(1), MAPKAPK2(1), TNF(1)	4716370	10	8	10	4	0	3	3	0	4	0	0.820	0.969	1.000
298	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	APAF1(2), ATM(5), BAX(1), BID(1), CASP6(1), CASP9(1), PRKCA(1), PTK2(1), PXN(1), STAT1(2), TLN1(6)	11079306	22	20	22	9	0	2	3	7	10	0	0.918	0.971	1.000
299	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(8), EP300(5), IKBKB(1), MAP2K3(1), MAP3K7(1), MAPK14(1), NFKBIA(1), NR3C1(2), RELA(2), TGFBR1(1), TLR2(1), TNF(1)	12451981	25	24	25	8	0	3	3	7	12	0	0.926	0.972	1.000
300	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(1), EGFR(1), HGS(1), TF(1), TFRC(2)	5366844	7	7	7	3	0	0	1	3	3	0	0.903	0.973	1.000
301	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ACTR3(1), WASF1(1), WASL(2)	3445473	6	6	6	3	0	2	2	2	0	0	0.824	0.974	1.000
302	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C2(1), C3(2), C5(1), C6(2), C7(1), C8A(2), C9(1), MASP1(2), MASP2(1), MBL2(1)	14575805	14	14	14	2	0	4	2	8	0	0	0.199	0.975	1.000
303	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(3), CDH1(2), CREBBP(8), EP300(5), MAP3K7(1), SKIL(2), TGFBR1(1)	10788868	22	21	22	6	0	2	4	7	9	0	0.740	0.976	1.000
304	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(8), EP300(5), IL7R(1), JAK1(2), JAK3(1), PIK3CA(6), PIK3R1(2), PTK2B(1), STAT5A(2), STAT5B(1)	11835018	29	27	27	7	2	6	4	7	10	0	0.504	0.977	1.000
305	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), GLI3(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), SHH(1), SMO(1), SUFU(2)	7090514	12	12	12	4	0	3	3	5	1	0	0.555	0.977	1.000
306	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(4), ACADL(3), ACADM(2), ACADSB(1), ACOX1(1), ACOX3(3), ACSL6(1), ADH6(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), CPT1A(1), CPT1B(1), CPT1C(1), CYP4A11(2), EHHADH(1), GCDH(2), HADHA(2), HSD17B4(1)	20639447	35	31	35	6	3	8	7	15	2	0	0.0790	0.978	1.000
307	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLR3A(3), POLR3G(1), POLR3GL(1), POLR3H(1)	9820864	20	19	20	5	2	3	1	7	7	0	0.505	0.978	1.000
308	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	CREB1(1), MAP2K2(1), MAP2K3(1), MAP3K1(3), MAPK1(1), MAPK14(1), PIK3CA(6), PIK3R1(2), RELA(2)	8193979	18	15	16	6	2	4	0	6	6	0	0.838	0.979	1.000
309	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSE(3), CYP11B1(1), HSD11B1(1), HSD17B8(1), SRD5A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2)	11471269	20	20	20	7	1	1	5	4	9	0	0.812	0.979	1.000
310	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	PTPRC(1), ZAP70(1)	3789564	2	2	2	2	0	0	0	1	1	0	0.980	0.980	1.000
311	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(2), CPT1A(1), LEPR(1), PRKAA1(1), PRKAG1(1), PRKAG2(3)	6043609	9	9	9	3	0	0	3	5	1	0	0.717	0.980	1.000
312	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(3), COL4A3(2), COL4A5(1), COL4A6(2), SLC23A1(2), SLC23A2(1)	10739948	13	12	13	3	0	6	0	4	3	0	0.640	0.980	1.000
313	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), GOT2(1), GPT(2), ME2(1), RPE(1), RPIA(2), TKT(2)	7627295	11	10	11	3	1	3	0	2	5	0	0.692	0.981	1.000
314	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), HSD17B1(1), HSD17B4(1)	3380470	3	3	3	2	1	1	0	0	1	0	0.922	0.981	1.000
315	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CAPN2(1), EP300(5), NFATC2(1), PPP3CB(1), PRKCA(1)	10249593	12	12	12	9	1	0	1	2	8	0	1.000	0.982	1.000
316	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(1), GABBR1(2), GPRC5C(1), GPRC5D(1), GRM1(1), GRM2(1), GRM3(2), GRM4(2), GRM5(1)	8754061	12	11	12	3	2	3	1	6	0	0	0.332	0.982	1.000
317	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR2(1), CCR3(1), CCR5(1), CCR7(1), IFNG(2), IFNGR1(1), IL12RB2(1), IL2(1), IL4R(2)	8425104	11	11	11	3	0	0	2	6	3	0	0.719	0.983	1.000
318	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(3), EIF2B5(1), EIF2S3(1), EIF5(1)	4844715	7	6	7	3	2	1	2	0	2	0	0.769	0.983	1.000
319	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	IFNG(2), IL18(1), IL1R1(1)	4552908	4	4	4	2	0	0	0	2	2	0	0.955	0.984	1.000
320	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), GNA13(2), GNB1(1), MYLK(1), PLCB1(1), PPP1R12B(1), PRKCA(1), ROCK1(2)	8643722	10	10	10	3	0	1	0	3	6	0	0.919	0.985	1.000
321	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(2), CYP7A1(1), HMGCR(1), LCAT(2), LDLR(2), LPL(4), LRP1(4), SOAT1(1)	11515774	17	17	17	4	2	2	2	8	3	0	0.469	0.986	1.000
322	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAPK14(1), RELA(2), TRAF5(1)	6070088	4	4	4	2	0	0	0	1	3	0	0.992	0.986	1.000
323	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ST3GAL4(1)	3017936	1	1	1	0	0	0	0	1	0	0	0.832	0.986	1.000
324	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(1), B4GALT1(2), B4GALT2(1), FUT4(2), FUT5(1), FUT6(1), GCNT2(2)	6764071	11	10	11	4	0	2	0	4	5	0	0.906	0.986	1.000
325	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNB1(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1)	4135590	7	7	7	3	0	1	1	3	2	0	0.891	0.987	1.000
326	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC10(1), ANAPC5(3), ANAPC7(1), BTRC(2), CDC16(1), CDC20(2), CDC23(1), CDC27(2), CUL1(2), CUL2(1), FBXW7(1), FZR1(1), SKP2(1), SMURF2(1), TCEB1(1), UBA1(1), VHL(3), WWP1(5), WWP2(1)	16693266	31	29	31	6	2	0	6	16	6	1	0.401	0.987	1.000
327	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	GRB2(1), ITGB1(1), MAPK1(1), PDK2(1), PIK3CA(6), PIK3R1(2), PTK2(1), SOS1(2)	7975750	15	14	13	6	2	5	0	3	5	0	0.751	0.989	1.000
328	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(2), GRB2(1), JAK2(1), PIK3CA(6), PIK3R1(2), PRKCA(1), RAF1(3), RASA1(2), SOS1(2), STAT1(2), STAT3(1), STAT5A(2), STAT5B(1), THPO(1)	12648591	27	25	25	6	2	6	2	8	9	0	0.515	0.989	1.000
329	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GRB2(1), INS(1), IRS1(2), JAK2(1), MAPK1(1), PIK3CA(6), PIK3R1(2), PRKCA(1), RAF1(3), SLC2A4(2), SOCS1(1), SOS1(2), STAT5A(2), STAT5B(1)	14057623	26	23	24	5	4	6	0	9	7	0	0.306	0.989	1.000
330	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(1), GNAI1(1), GNB1(1), ITGA1(3), ITGB1(1), MAPK1(1), PLA2G4A(1), PLCB1(1), PRKCA(1), PTK2(1), RAF1(3), TBXAS1(1)	10205931	18	18	18	6	3	1	1	6	7	0	0.743	0.989	1.000
331	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	PPOX(1)	3256503	1	1	1	3	0	0	0	0	1	0	1.000	0.989	1.000
332	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C2(1), C3(2), C5(1), C6(2), C7(1), C8A(2), C8B(1), C9(1), MASP1(2)	14319678	13	13	13	2	0	4	1	8	0	0	0.245	0.990	1.000
333	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), HEXA(1), HEXB(1), LCT(1), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(1)	8730691	8	8	8	2	1	0	0	4	3	0	0.562	0.990	1.000
334	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP29(1), STX11(1), STX17(1), STX18(3), TSNARE1(1), VAMP1(1), VTI1B(1)	7031491	9	9	9	3	0	3	0	4	2	0	0.637	0.990	1.000
335	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(2), ACADL(3), ACADM(2), ACADSB(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH6A1(1), EHHADH(1), HADHA(2), PCCA(1), PCCB(1), SUCLA2(1), SUCLG1(1)	13955083	24	23	24	5	2	3	5	10	4	0	0.313	0.990	1.000
336	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(1), NFKBIA(1), PIK3CA(6), PIK3R1(2), RELA(2)	6144997	12	11	10	6	1	5	0	3	3	0	0.907	0.991	1.000
337	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), HEXA(1), HEXB(1), LCT(1), MAN2C1(1), MANBA(1)	7073422	6	6	6	2	0	0	0	3	3	0	0.740	0.991	1.000
338	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	EIF4A1(1), EIF4A2(3), EIF4B(1), EIF4G1(3), EIF4G2(1), EIF4G3(4), PDK2(1), PIK3CA(6), PIK3R1(2), TSC1(2), TSC2(6)	11553337	30	28	28	8	3	7	3	9	8	0	0.530	0.992	1.000
339	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(1), MAPT(1)	3972386	2	2	2	6	0	0	0	1	1	0	1.000	0.992	1.000
340	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), GOT2(1), GPT(2), PGK2(1), RPE(1), RPIA(2), TKT(2)	8522981	11	10	11	3	1	3	0	2	5	0	0.690	0.992	1.000
341	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), BAIAP2(2), GAPDH(1), INS(1), MAGI1(2), RERE(6), WWP1(5), WWP2(1)	10045952	21	21	21	7	2	0	3	10	5	1	0.936	0.992	1.000
342	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	GATA1(2)	3507070	2	2	2	4	1	0	0	0	1	0	0.997	0.992	1.000
343	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(1), ALG11(1), ALG14(1), ALG2(1), ALG6(1), ALG9(2), B4GALT1(2), B4GALT2(1), DHDDS(1), DPAGT1(2), MAN1B1(1), MAN1C1(2), MAN2A1(2), MGAT4B(1), MGAT5(1), MGAT5B(1), RPN1(2), RPN2(1), ST6GAL1(1)	17957001	25	23	25	4	0	3	4	8	10	0	0.377	0.993	1.000
344	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG7(2), IFNA2(2), IFNG(2), INS(1), PIK3C3(1), PIK3R4(1), PRKAA1(1), ULK1(1), ULK2(1), ULK3(1)	8945177	13	13	13	4	1	1	1	7	3	0	0.760	0.993	1.000
345	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	ESCO1(2), PNPLA3(1)	6879195	3	3	3	0	0	2	0	1	0	0	0.358	0.993	1.000
346	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH6(2), AKR1C1(1), AKR1C2(1), AKR1C3(2), ALDH1A3(1), CYP1A2(2), CYP1B1(1), CYP2C18(2), CYP2C8(1), CYP2F1(1), CYP3A43(2), CYP3A7(1), DHDH(2), GSTA1(2), GSTA2(1), GSTK1(2), GSTM1(1), GSTM4(1), GSTT1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1)	24168481	43	40	43	8	1	3	7	23	8	1	0.367	0.993	1.000
347	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	FHL5(1), XPO1(2)	4047018	3	3	3	4	1	0	1	0	1	0	0.995	0.993	1.000
348	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ACTR3(1), PAK1(2), PDGFRA(1), PIK3CA(6), PIK3R1(2), WASL(2)	5639771	15	14	13	5	2	5	3	3	2	0	0.665	0.995	1.000
349	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), BIRC2(1), BIRC3(2), CASP10(1), CASP4(1), CASP6(1), CASP9(1), LMNA(2), LMNB1(1), LMNB2(1)	8124111	13	13	13	4	0	2	2	5	4	0	0.687	0.995	1.000
350	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	GNB1(1), NOS3(1), NR3C1(2), PIK3CA(6), PIK3R1(2), RELA(2)	7604377	14	13	12	6	2	4	0	4	4	0	0.926	0.995	1.000
351	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(2), ATM(5), BAX(1), CPB2(1), HIF1A(2), HSPA1A(1)	8766541	12	12	12	4	0	2	2	4	3	1	0.800	0.995	1.000
352	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	CFTR(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), SLC9A3R1(1)	5568417	6	6	6	5	0	1	1	2	2	0	0.981	0.996	1.000
353	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(5), ATR(2), CDC25C(1), CHEK1(1), CHEK2(1)	6300264	10	10	10	6	0	3	1	4	2	0	0.951	0.996	1.000
354	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	F2(2), F2R(1), GNA13(2), GNAI1(1), GNB1(1), MAP3K7(1), PIK3CA(6), PIK3R1(2), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2B(1), ROCK1(2)	10806720	22	20	20	8	2	4	1	8	7	0	0.895	0.996	1.000
355	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(1), CDKN2A(1), PIK3CA(6), PIK3R1(2), POLR1A(5), POLR1B(2)	8201270	17	15	15	5	2	6	0	4	5	0	0.520	0.996	1.000
356	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(2), ACACB(1), FASN(4), MCAT(2), OLAH(1), OXSM(2)	6810274	12	12	12	5	1	3	0	5	3	0	0.779	0.996	1.000
357	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), ATP7A(2), ATP7B(4), COX10(3), COX5A(1), COX7A1(1), COX7C(1), COX8A(1), NDUFB4(2), NDUFB5(1), NDUFB7(1), NDUFS1(1), NDUFV1(1), SDHA(1), SHMT1(2), UQCRC1(1)	16120443	35	32	35	8	1	3	6	14	11	0	0.548	0.996	1.000
358	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(1), AOC2(2), ESCO1(2), GOT2(1), HPD(1), LPO(1), MAOA(1), MAOB(3), MPO(1), PNPLA3(1), PRDX6(2), TAT(1)	14388552	17	17	17	4	2	3	2	5	5	0	0.446	0.996	1.000
359	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSE(3), ASAH1(1), GAL3ST1(1), GALC(1), LCT(1), PPAP2B(1), SMPD1(4), SMPD2(1), SPTLC1(2), SPTLC2(1)	10228649	16	16	15	8	3	2	0	5	6	0	0.929	0.996	1.000
360	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(2), JAK1(2), JAK2(1)	4391912	5	5	5	3	1	0	1	2	1	0	0.918	0.996	1.000
361	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(2), JAK1(2), JAK2(1)	4391912	5	5	5	3	1	0	1	2	1	0	0.918	0.996	1.000
362	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), POLR2A(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2)	5423744	6	6	6	3	0	1	1	2	2	0	0.763	0.997	1.000
363	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	CTNNA1(5), CTNNA2(1), CTNNB1(2), PTK2(1), PXN(1), VCL(1)	8083387	11	11	11	7	0	1	2	4	4	0	0.968	0.997	1.000
364	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), PRKACG(1), PRKAG1(1), PRKAR2B(2)	4248454	7	7	7	4	0	1	2	3	1	0	0.879	0.997	1.000
365	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C2(1), C3(2), C5(1), C6(2), C7(1), C8A(2), C9(1)	12947139	10	10	10	2	0	3	1	6	0	0	0.403	0.997	1.000
366	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ASAH1(1), GNAI1(1), GNB1(1), ITGAV(1), ITGB3(3), MAPK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(2), PLCB1(1), PRKCA(1), PTK2(1), SMPD1(4), SMPD2(1), SPHK1(1)	11494201	26	25	23	9	5	6	0	8	7	0	0.727	0.997	1.000
367	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	IKBKAP(1), IKBKB(1), MAP3K1(3), NFKBIA(1), RELA(2), TNFAIP3(2)	7933738	10	9	10	5	0	1	0	5	4	0	0.988	0.997	1.000
368	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(1), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), NFAT5(2), PDE6A(1), PDE6B(2), SLC6A13(4), TF(1)	15120160	33	30	33	9	2	4	7	12	8	0	0.592	0.997	1.000
369	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	59	APC(3), AXIN1(3), CCND3(1), CSNK1E(3), CTNNB1(2), DVL3(1), FBXW2(1), FZD1(1), FZD2(1), FZD5(2), FZD7(3), FZD8(2), LDLR(2), MAPK10(1), PAFAH1B1(1), PPP2R5C(2), PPP2R5E(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCI(3), WNT10A(2), WNT2(1), WNT2B(1), WNT7A(1), WNT7B(1)	24908717	48	43	48	9	6	5	2	21	14	0	0.172	0.997	1.000
370	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	HEXA(1), HEXB(1), IDUA(1), LCT(1), NAGLU(1)	6243845	5	5	5	4	0	1	0	2	2	0	0.969	0.997	1.000
371	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CRY1(1), CSNK1E(3), PER1(4), PER2(2), PER3(2)	7217419	13	13	13	9	3	0	1	6	3	0	0.988	0.997	1.000
372	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), IFNG(2), IKBKB(1), IL2(1), MAP3K1(3), MAPK14(1), NFKBIA(1), RELA(2)	8201375	12	9	12	5	0	0	0	8	4	0	0.972	0.997	1.000
373	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), IFNG(2), IL12RB2(1), JAK2(1)	6205716	5	5	5	3	0	0	0	3	2	0	0.968	0.998	1.000
374	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), H6PD(1), PFKP(1), PGD(1), PGM1(1), PRPS2(1), RBKS(1), RPE(1), RPIA(2), TAL1(1), TKT(2)	8545294	14	13	14	5	1	4	2	3	4	0	0.788	0.998	1.000
375	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(2), PGM1(1)	4961998	4	4	4	3	0	1	0	2	1	0	0.961	0.998	1.000
376	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNB1(1), LIMK1(1), MAPK1(1), NOX1(1), PIK3C2G(3), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2(1), RAF1(3), ROCK2(1)	10612980	16	16	16	9	2	2	2	4	6	0	0.964	0.998	1.000
377	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(8), DAXX(1), PML(1), SP100(1), TNF(1), TNFRSF1B(2)	7601081	14	13	14	6	0	3	3	4	4	0	0.798	0.998	1.000
378	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B5(1), EIF2S3(1), FLT1(1), FLT4(4), HIF1A(2), KDR(1), NOS3(1), PIK3CA(6), PIK3R1(2), PRKCA(1), PTK2(1), PXN(1), VHL(3)	14452438	25	24	23	9	5	5	1	5	8	1	0.810	0.998	1.000
379	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(1), DIAPH1(2), GSN(1), ITGA1(3), ITGB1(1), MAPK1(1), MYLK(1), PFN1(1), PIK3CA(6), PIK3R1(2), PTK2(1), PXN(1), RAF1(3), ROCK1(2), TLN1(6)	15768831	32	26	30	8	3	5	1	12	11	0	0.604	0.998	1.000
380	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(1), DOCK1(1), ELK1(1), GRB2(1), HGF(1), ITGA1(3), ITGB1(1), MAP2K2(1), MAP4K1(1), MAPK1(1), PAK1(2), PIK3CA(6), PIK3R1(2), PTK2(1), PTK2B(1), PXN(1), RAF1(3), RASA1(2), SOS1(2), STAT3(1)	17205799	33	31	31	8	4	8	2	9	10	0	0.401	0.998	1.000
381	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AMDHD1(1), AOC2(2), FTCD(1), HDC(1), MAOA(1), MAOB(3), METTL2B(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), PRPS2(1)	16819000	26	22	26	5	4	2	4	11	5	0	0.236	0.998	1.000
382	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), ETV5(2), IFNG(2), IL12RB2(1), IL18(1), JAK2(1), MAPK14(1)	7826288	9	8	9	3	0	1	0	5	3	0	0.867	0.999	1.000
383	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), MAP3K1(3), MAPK1(1), NSMAF(1), RAF1(3), RELA(2), RIPK1(1), SMPD1(4)	8596933	16	13	15	8	3	1	1	6	5	0	0.980	0.999	1.000
384	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH6(2), ESCO1(2), PNPLA3(1)	10394276	7	7	7	2	0	3	0	4	0	0	0.623	0.999	1.000
385	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(3), CR2(1), ICAM1(1), ITGAL(1), ITGB2(1), PTPRC(1)	7118068	8	7	8	3	0	2	0	3	3	0	0.911	0.999	1.000
386	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	NFATC2(1), NFATC3(3), PPP3CB(1), PRKCA(1), SP3(1)	8782821	7	7	7	4	0	0	2	1	4	0	0.977	0.999	1.000
387	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	EIF2B5(1), EIF2S3(1), IGF1R(2), INPPL1(2), PDK2(1), PIK3CA(6), PIK3R1(2)	8195184	15	14	13	5	4	4	0	4	3	0	0.717	0.999	1.000
388	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	IKBKB(1), MAP2K3(1), MAP3K1(3), MAP4K2(2), MAPK14(1), NFKBIA(1), RELA(2), RIPK1(1), TNF(1)	10419138	13	12	13	8	0	1	2	5	5	0	0.995	0.999	1.000
389	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(1), ELK1(1), PIK3CA(6), PIK3R1(2), RAF1(3), RALA(1), RALBP1(2), RELA(2)	8105105	18	16	16	8	2	7	0	5	4	0	0.888	0.999	1.000
390	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNB1(1), PRKAA1(1), PRKACG(1), PRKAG1(1), PRKAG2(3), PRKAR1A(1), PRKAR2B(2)	6532754	10	10	10	4	0	1	3	4	2	0	0.765	0.999	1.000
391	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	CREB1(1), GRB2(1), MAPK1(1), MEF2C(1), NTRK1(1), PIK3CA(6), PIK3R1(2)	8198895	13	11	11	6	2	4	0	4	3	0	0.717	0.999	1.000
392	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	IKBKB(1), IL1R1(1), MAP3K1(3), MAP3K7(1), NFKBIA(1), RELA(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1B(2)	10476520	15	14	15	6	0	2	1	7	5	0	0.965	0.999	1.000
393	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNB1(2), PIK3CA(6), PIK3R1(2), PTK2(1), PTK2B(1), TERT(3)	6992141	15	14	13	6	1	4	1	7	2	0	0.669	0.999	1.000
394	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(3), ASAH1(1), CERK(1), CREB1(1), DAG1(3), EPHB2(1), ITPKA(1), ITPKB(1), MAP2K7(2), MAPK1(1), MAPK10(1), MAPK8IP1(1)	12058795	17	16	17	7	2	0	3	6	6	0	0.909	0.999	1.000
395	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(2), GCK(1), GMDS(1), GMPPA(1), HK1(2), KHK(2), MPI(1), PFKFB3(2), PFKFB4(1), PFKP(1)	10150439	14	13	14	6	0	3	2	5	4	0	0.905	1.000	1.000
396	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), F2(2), GNAI1(1), GNB1(1), GRB2(1), JAK2(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPT(1), MYLK(1), PRKCA(1), PTK2B(1), RAF1(3), SOS1(2), STAT1(2), STAT3(1), STAT5A(2)	17711931	31	28	31	7	4	4	0	15	8	0	0.423	1.000	1.000
397	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(3), COL4A3(2), COL4A5(1), COL4A6(2), F10(1), F12(6), F2(2), F2R(1), F5(3), F8(1), F9(1), PROS1(1)	18773061	26	24	26	6	2	6	3	7	8	0	0.474	1.000	1.000
398	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	GRB2(1), MAP2K2(1), MAP2K3(1), MAP3K1(3), MAPK1(1), MAPK14(1), PAK1(2), PRKCA(1), PTK2B(1), RAF1(3), SOS1(2)	11994967	17	16	17	8	1	1	1	8	6	0	0.977	1.000	1.000
399	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ACTR3(1), NCKAP1(1), NTRK1(1), PSMA7(1), WASF1(1), WASL(2)	6431404	9	9	9	6	0	3	2	3	1	0	0.896	1.000	1.000
400	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(1), MAP2(1), PRKACG(1), PRKAG1(1), PRKAR2B(2), PRKCE(2)	7304465	8	7	8	5	0	2	1	3	2	0	0.927	1.000	1.000
401	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDT1(1), DIAPH2(1), MCM10(1), MCM2(1), MCM3(2), MCM5(1), MCM6(2), NACA(1), POLD1(2), POLD2(1), POLE(1), RFC4(1), RFC5(1), RPA2(1), RPA4(1), UBA52(1), UBC(2)	21391245	23	22	23	4	2	6	4	9	2	0	0.115	1.000	1.000
402	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	IKBKAP(1), IKBKB(1), MAP3K1(3), NFKBIA(1), RELA(2), RIPK1(1), TNFAIP3(2), TNFRSF1B(2)	9722679	13	12	13	7	0	2	1	6	4	0	0.988	1.000	1.000
403	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), MAPK14(1), PRKCA(1), PTK2B(1)	5735990	4	4	4	3	0	0	0	3	1	0	0.987	1.000	1.000
404	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), H6PD(1), PFKL(1), PFKP(1), PGD(1), PGM1(1), PRPS2(1), RBKS(1), RPE(1), RPIA(2), TKT(2)	10246833	14	13	14	6	2	4	2	2	4	0	0.839	1.000	1.000
405	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCND3(1), CDC25A(1), CDK4(1), CDKN2A(1)	6773795	4	4	4	3	1	0	1	1	1	0	0.897	1.000	1.000
406	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IKBKB(1), IL1R1(1), IL1RN(1), MAP2K3(1), MAP3K1(3), MAP3K7(1), MAPK14(1), NFKBIA(1), RELA(2), TNF(1)	12411204	13	12	13	6	0	1	0	6	6	0	0.994	1.000	1.000
407	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	RPE(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1), XYLB(2)	10951920	20	19	20	6	0	3	7	7	3	0	0.609	1.000	1.000
408	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CANX(2), CIITA(2), CREB1(1), CTSB(1), HLA-A(1), HLA-B(1), HLA-C(3), HLA-DOB(1), HLA-DPB1(1), HLA-DQA2(1), HSP90AA1(1), IFI30(1), IFNA2(2), KIR3DL3(1), KLRC3(1), NFYA(3), NFYC(1), PSME2(1), RFX5(2)	20022746	29	27	29	7	1	4	4	10	9	1	0.590	1.000	1.000
409	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSE(3), CYP11B1(1), HSD11B1(1), HSD17B1(1), HSD17B8(1), METTL2B(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), SRD5A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1)	20577620	32	29	32	8	1	1	8	9	13	0	0.584	1.000	1.000
410	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), ELK1(1), GRB2(1), JAK1(2), MAP3K1(3), PDGFRA(1), PIK3CA(6), PIK3R1(2), PRKCA(1), RAF1(3), RASA1(2), SOS1(2), STAT1(2), STAT3(1), STAT5A(2)	14720099	31	25	29	8	4	7	2	9	9	0	0.527	1.000	1.000
411	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(1), ATM(5), BRCA1(3), CHEK1(1), CHEK2(1), MRE11A(2), NFKBIA(1), RBBP8(2), RELA(2)	12100245	18	18	18	9	0	2	1	10	5	0	0.969	1.000	1.000
412	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	BAX(1), CSF2RB(3), IGF1R(2), PIK3CA(6), PIK3R1(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2)	9197946	18	17	16	9	1	5	2	7	3	0	0.891	1.000	1.000
413	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(1), AKT3(1), CISH(2), GRB2(1), IL4R(2), JAK1(2), JAK2(1), JAK3(1), PI3(1), PIK3CA(6), PPP1R13B(2), SOS1(2), SOS2(1)	15480556	23	20	21	5	2	6	2	9	4	0	0.239	1.000	1.000
414	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(4), DCK(1), DPYD(1), DPYS(1), DUT(1), NT5C(1), NT5M(1), NUDT2(1), POLB(1), POLD1(2), POLD2(1), POLE(1), POLG(2), POLL(1), POLQ(3), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLRMT(2), RRM1(2), TK2(1), TXNRD1(1), UMPS(2), UNG(1), UPB1(1), UPP1(1)	24416329	42	39	42	9	2	4	6	14	16	0	0.396	1.000	1.000
415	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(1), ELK1(1), GNB1(1), MAP2K2(1), MAP2K3(1), MAP3K1(3), MAPK1(1), MAPK14(1), NCF2(1), NFATC2(1), NFATC3(3), NFKBIA(1), PAK1(2), PIK3C2G(3), PLCB1(1), PPP3CB(1), RAF1(3), RELA(2)	16331465	30	27	30	9	2	3	3	12	10	0	0.845	1.000	1.000
416	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), DARS(3), EPRS(1), KARS(1), LARS(4), MARS(1), QARS(3), RARS(2), TARS(1)	13420837	18	17	18	5	1	0	4	7	6	0	0.787	1.000	1.000
417	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), AGT(3), AGTR2(1), ANPEP(5), CMA1(1), CTSA(1), ENPEP(2), LNPEP(2), MAS1(1), MME(1)	8844682	21	17	21	7	2	1	6	11	1	0	0.573	1.000	1.000
418	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	PRKACG(1), PRKAR1A(1), PRKAR2B(2)	6272754	4	4	4	4	0	1	1	1	1	0	0.974	1.000	1.000
419	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	ELK1(1), GRB2(1), LYN(3), MAP3K1(3), MAPK14(1), NFATC2(1), NFATC3(3), PPP3CB(1), PRKCA(1), RAF1(3), SOS1(2), VAV1(3)	16023855	23	21	23	5	1	3	1	11	7	0	0.602	1.000	1.000
420	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	DAG1(3), EPHB2(1), FBXW7(1), GRB2(1), ITK(1), ITPKA(1), ITPKB(1), LCP2(1), MAPK1(1), NFAT5(2), NFKB2(2), NFKBIA(1), NFKBIL1(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PTPRC(1), RAF1(3), RASGRP1(1), RASGRP3(1), RASGRP4(1), SOS1(2), SOS2(1), VAV1(3), ZAP70(1)	23842032	39	37	39	9	4	6	5	14	10	0	0.333	1.000	1.000
421	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CREBBP(8), GNB1(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PTPRC(1), ZAP70(1)	9722945	15	14	15	8	0	3	4	5	3	0	0.901	1.000	1.000
422	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CREBBP(8), GNB1(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PTPRC(1), ZAP70(1)	9722945	15	14	15	8	0	3	4	5	3	0	0.901	1.000	1.000
423	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	MAP3K1(3), NFATC2(1), NFKBIA(1), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), RELA(2)	11716299	12	11	12	9	0	1	2	4	5	0	0.997	1.000	1.000
424	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DLAT(1), DLD(2), HAGH(1), ME2(1), PC(5), PCK1(5)	15534483	24	23	24	8	2	1	6	8	6	1	0.821	1.000	1.000
425	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	HEXA(1), HEXB(1), HGSNAT(1), HPSE(1), HYAL1(1), HYAL2(1), IDUA(1), LCT(1), NAGLU(1), SPAM1(1)	8859011	10	10	10	7	1	1	1	5	2	0	0.959	1.000	1.000
426	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), EGF(1), EGFR(1), ELK1(1), GRB2(1), JAK1(2), MAP3K1(3), PIK3CA(6), PIK3R1(2), PRKCA(1), RAF1(3), RASA1(2), SOS1(2), STAT1(2), STAT3(1), STAT5A(2)	15780425	32	27	30	9	3	7	3	10	9	0	0.606	1.000	1.000
427	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA3(1), ANXA4(1), CYP11A1(1), HSD11B1(1), PLA2G4A(1), PTGDR(1), PTGFR(2), PTGS2(1), TBXAS1(1)	9219276	10	8	10	5	1	1	2	4	2	0	0.834	1.000	1.000
428	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT2(1), AKT3(1), BCR(2), CDKN2A(1), DAPP1(1), FLOT1(1), ITPR1(6), ITPR2(5), ITPR3(3), LYN(3), PIK3CA(6), PLCG2(1), PPP1R13B(2), PREX1(2), PTPRC(1), RPS6KA3(1), VAV1(3)	22858175	40	33	38	9	3	8	3	18	8	0	0.262	1.000	1.000
429	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP4A(1), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5L(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1E2(2), ATP6V1H(1), COX10(3), COX15(2), COX5A(1), COX7A1(1), COX7C(1), COX8A(1), NDUFB10(1), NDUFB4(2), NDUFB5(1), NDUFB7(1), NDUFB9(1), NDUFS1(1), NDUFS3(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), PPA1(2), SDHA(1), SDHD(1), TCIRG1(1), UQCRC1(1), UQCRC2(2)	23761375	55	52	55	12	2	3	12	21	17	0	0.346	1.000	1.000
430	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	CAMK2A(1), CAMK2B(2), CAMK2D(1), CREB1(1), GRB2(1), MAPK1(1), MAPK14(1), PIK3CA(6), PIK3R1(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), RPS6KA5(1), SOS1(2)	12343499	24	22	22	7	3	8	1	7	5	0	0.441	1.000	1.000
431	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(3), ASAH1(1), CERK(1), GAL3ST1(1), GALC(1), LCT(1), PPAP2B(1), SGMS1(1), SGPP1(1), SMPD1(4), SMPD2(1), SMPD3(2), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(2), SPTLC2(1)	15076420	25	24	24	8	4	4	1	9	7	0	0.580	1.000	1.000
432	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	EGFR(1), IGF1R(2), POLR2A(1), PRKCA(1), TEP1(5), TERF1(1), TERT(3), TNKS(1), XRCC5(2)	11465892	17	17	17	5	1	2	2	8	4	0	0.689	1.000	1.000
433	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	AKT2(1), AKT3(1), CDKN2A(1), DAPP1(1), GRB2(1), IGFBP1(1), PIK3CA(6), PPP1R13B(2), RPS6KA3(1), SFN(1), SOS1(2), SOS2(1)	14725507	19	18	17	5	1	6	2	6	4	0	0.334	1.000	1.000
434	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(3), ATF2(1), AXIN1(3), BMP4(1), BMP7(1), BMPR1A(2), BMPR2(1), CHRD(1), CTNNB1(2), FZD1(1), MAP3K7(1), MEF2C(1), NKX2-5(1), TGFBR1(1)	15368413	20	19	20	5	1	2	2	13	2	0	0.495	1.000	1.000
435	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(1), PGAP1(4), PIGK(1), PIGM(1), PIGU(1)	10228833	8	8	8	3	0	2	0	3	3	0	0.775	1.000	1.000
436	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(1), EGFR(1), MAP3K1(3), MAPK14(1), NCOR2(1), RXRA(2), THRA(1)	7349352	10	8	10	7	0	2	2	5	1	0	0.978	1.000	1.000
437	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(1), AP2A1(2), AP2M1(1), BIN1(1), PICALM(2), PPP3CB(1), SYNJ2(1)	9352756	9	9	9	7	0	0	5	2	2	0	0.985	1.000	1.000
438	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	94	ANK2(8), B3GALT4(1), IL6ST(2), PIGK(1), RPL10(1), RPL11(1), RPL13(1), RPL18A(1), RPL22(1), RPL24(1), RPL26(1), RPL28(1), RPL3(1), RPL35(1), RPL3L(1), RPL6(1), RPL7A(1), RPS14(1), RPS16(1), RPS2(1), RPS20(1), RPS6KA3(1), RPS6KB2(1), RPS8(1), RPSA(1), SLC36A2(2), UBA52(1), UBC(2)	21912168	38	37	38	8	2	2	4	20	10	0	0.449	1.000	1.000
439	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	CREB1(1), ELK1(1), GNAI1(1), GNB1(1), NFATC2(1), NFATC3(3), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), RAF1(3), RPS6KA3(1)	14740330	18	18	18	7	0	2	3	6	7	0	0.905	1.000	1.000
440	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(4), EGFR(1), ERBB2(3), ERBB4(4), ETS1(2), FMN2(1), GRB2(1), MAPK1(1), NOTCH1(2), NOTCH2(1), NOTCH3(4), NOTCH4(1), PIWIL3(1), PIWIL4(2), RAF1(3), SOS1(2), SOS2(1), SPIRE2(2)	22083578	36	35	34	9	3	5	5	13	10	0	0.402	1.000	1.000
441	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), CHRM1(2), FLT1(1), FLT4(4), KDR(1), NOS3(1), PDE3A(2), PDE3B(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKG1(2), PRKG2(2), RYR2(5), SLC7A1(1)	17299609	28	24	28	8	2	6	2	13	5	0	0.533	1.000	1.000
442	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(2), B4GALT2(1), GAA(2), GCK(1), HK1(2), LCT(1), MGAM(3), PFKP(1), PGM1(1)	13655636	14	11	14	7	0	2	0	5	7	0	0.991	1.000	1.000
443	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA2A(1), CHRM1(2), CHRM2(1), CHRM3(1), DRD2(1), DRD4(1), DRD5(1), HTR1A(1), HTR1B(1), HTR2B(2)	10828382	12	11	12	5	2	2	0	5	3	0	0.716	1.000	1.000
444	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	EPHB2(1), F2(2), F2RL2(1), MAP2K5(2), MAPK1(1), PLD1(1), PLD3(1), PTK2(1), RAF1(3), RASAL1(1), VAV1(3)	11636431	17	17	17	5	3	1	2	9	2	0	0.515	1.000	1.000
445	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), CDC25C(1), GNAI1(1), GNB1(1), MAPK1(1), MYT1(6), PRKACG(1), PRKAR1A(1), PRKAR2B(2)	8764490	15	13	15	5	1	7	2	4	1	0	0.467	1.000	1.000
446	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(1), AGPAT2(1), AGPS(1), CPT1B(1), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), GPD1(2), GPD2(1), LCAT(2), PAFAH1B1(1), PCYT1A(1), PLA2G4A(1), PLA2G6(2), PLCB2(3), PLCG2(1), PPAP2B(1)	21393378	30	29	30	7	4	4	5	9	8	0	0.301	1.000	1.000
447	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH6(2), AGPAT1(1), AGPAT2(1), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), CEL(1), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), GK(1), LCT(1), LPL(4), PPAP2B(1)	20567654	31	29	31	8	3	3	5	12	8	0	0.455	1.000	1.000
448	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP5(1), ARHGAP6(1), ARHGEF11(1), ARHGEF5(2), BAIAP2(2), DIAPH1(2), GSN(1), LIMK1(1), MYLK(1), PFN1(1), PPP1R12B(1), ROCK1(2), TLN1(6), VCL(1)	19988739	25	23	25	7	1	3	2	9	10	0	0.688	1.000	1.000
449	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(1), AGPS(1), PAFAH1B1(1), PAFAH1B2(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLD1(1), PPAP2B(1)	9927654	11	11	11	6	2	2	1	4	2	0	0.877	1.000	1.000
450	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(3), AXIN1(3), BTRC(2), CREBBP(8), CSNK2A1(2), CTBP1(1), CTNNB1(2), FZD1(1), MAP3K7(1), WIF1(1)	12529904	24	23	24	9	2	3	4	11	4	0	0.776	1.000	1.000
451	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(1), ATM(5), ATR(2), CDC25A(1), CDK4(1), CDKN2A(1), SKP2(1)	12363054	12	11	12	8	1	2	2	4	3	0	0.959	1.000	1.000
452	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT2(1), AKT3(1), APC(3), AXIN1(3), AXIN2(2), CER1(1), CTNNB1(2), LRP1(4), NKD1(2), NKD2(1), PSEN1(1), PTPRA(1), SENP2(1), WIF1(1)	17055103	24	24	24	6	3	2	1	16	2	0	0.405	1.000	1.000
453	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(2), ACACB(1), ACADM(2), ACSS1(1), ACSS2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH6A1(1), EHHADH(1), HADHA(2), PCCA(1), PCCB(1), SUCLA2(1), SUCLG1(1)	16739208	23	22	23	6	2	1	3	10	7	0	0.614	1.000	1.000
454	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CREB1(1), EEF2K(1), ELK1(1), IL1R1(1), MAP2K3(1), MAP3K10(1), MAP3K4(3), MAP3K7(1), MAPK1(1), MAPK14(1), MAPKAPK2(1), MKNK2(1)	14256462	14	14	14	7	1	3	1	4	5	0	0.959	1.000	1.000
455	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BIRC2(1), BIRC3(2), CFLAR(2), MAP3K3(1), MAP3K7(1), NFKB2(2), NFKBIA(1), NFKBIL1(1), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1B(2)	11936711	19	19	19	7	2	3	2	9	3	0	0.723	1.000	1.000
456	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(2), AP2M1(1), EEA1(1), GRASP(1), LYN(3), PFKL(1), PFKP(1), PRKCE(2)	10542377	12	11	12	8	1	1	2	6	2	0	0.979	1.000	1.000
457	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	ELK1(1), IKBKB(1), MAP2K3(1), MAP3K1(3), MAP3K7(1), MAPK14(1), NFKBIA(1), RELA(2), TLR10(1), TLR2(1), TLR3(2), TLR6(1), TLR7(1)	15522847	17	15	17	8	0	2	1	9	5	0	0.978	1.000	1.000
458	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH6(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDOB(2), DLAT(1), DLD(2), ENO1(1), ENO2(1), GAPDH(1), GCK(1), HK1(2), PFKP(1), PGM1(1)	20477333	23	23	23	8	2	3	4	6	7	1	0.844	1.000	1.000
459	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH6(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDOB(2), DLAT(1), DLD(2), ENO1(1), ENO2(1), GAPDH(1), GCK(1), HK1(2), PFKP(1), PGM1(1)	20477333	23	23	23	8	2	3	4	6	7	1	0.844	1.000	1.000
460	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2A2(1), GTF2B(2), GTF2F1(1), GTF2H4(1), GTF2IRD1(1), TAF1(1), TAF12(1), TAF2(2), TAF4B(2), TAF5L(1), TAF6(1), TAF7(1), TAF7L(1), TAF9(1), TBPL2(1)	15742156	20	20	20	7	3	4	4	4	5	0	0.599	1.000	1.000
461	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(2), C5(1), C6(2), C7(1), ICAM1(1), ITGA4(1), ITGAL(1), ITGB1(1), ITGB2(1), TNF(1), VCAM1(1)	10330878	13	12	13	5	0	2	1	8	2	0	0.890	1.000	1.000
462	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH6(2), ALDH1A3(1), AOC2(2), COMT(1), DCT(1), GOT2(1), HPD(1), MAOA(1), MAOB(3), TAT(1)	13378552	14	14	14	7	2	2	1	6	3	0	0.877	1.000	1.000
463	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(3), AXIN1(3), CTNNB1(2), FZD1(1), GNAI1(1), LEF1(1), PIK3CA(6), PIK3R1(2), RELA(2)	13080858	21	19	19	7	2	5	0	11	3	0	0.730	1.000	1.000
464	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT1(2), B4GALT2(1), GAA(2), GANC(1), GCK(1), HK1(2), LCT(1), MGAM(3), PFKL(1), PFKP(1), PGM1(1), RDH11(1), RDH12(3), RDH13(1)	16192342	21	18	21	7	1	3	0	10	7	0	0.877	1.000	1.000
465	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(3), CAMK1(2), CAMK1G(1), HDAC5(3), IGF1R(2), INS(1), MAPK14(1), MEF2C(1), NFATC2(1), PIK3CA(6), PIK3R1(2), PPP3CB(1)	14748409	24	23	22	9	4	4	2	10	4	0	0.738	1.000	1.000
466	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN2A(4), GRIN2B(1), GRIN2D(2), NOS1(1), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1)	10899913	14	14	14	6	0	1	5	6	2	0	0.811	1.000	1.000
467	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), HEXA(1), HEXB(1), HGSNAT(1), HPSE(1), HYAL1(1), HYAL2(1), IDUA(1), LCT(1), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(1), NAGLU(1), SPAM1(1)	14906286	15	15	15	9	2	1	1	7	4	0	0.924	1.000	1.000
468	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(1), AGT(3), CALR(1), CAMK1(2), CAMK1G(1), CREBBP(8), F2(2), HAND2(1), LIF(1), MAPK1(1), MAPK14(1), MEF2C(1), NFATC2(1), NFATC3(3), NKX2-5(1), PIK3CA(6), PIK3R1(2), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), RAF1(3)	21395683	44	40	42	11	6	8	7	15	8	0	0.265	1.000	1.000
469	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(3), AMY1A(2), AMY1B(2), AMY1C(2), AMY2B(1), ENPP1(2), ENPP3(1), GAA(2), GBE1(1), GCK(1), GYS2(1), HK1(2), MGAM(3), PGM1(1), PYGB(1), PYGM(1), SI(2), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2)	28161509	42	32	42	9	4	2	6	15	15	0	0.563	1.000	1.000
470	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(3), DARS(3), EPRS(1), FARSA(2), IARS2(4), KARS(1), LARS(4), MARS(1), NARS2(1), PARS2(1), QARS(3), RARS(2), RARS2(2), TARS(1), VARS(1), VARS2(3), YARS2(1)	22791849	36	32	36	9	2	3	7	15	9	0	0.612	1.000	1.000
471	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOB(2), GMDS(1), GMPPA(1), HK1(2), KHK(2), MPI(1), MTMR2(2), MTMR6(1), PFKFB3(2), PFKFB4(1), PFKL(1), PFKP(1), PHPT1(1), RDH11(1), RDH12(3), RDH13(1)	15806092	23	22	23	8	1	5	3	10	4	0	0.725	1.000	1.000
472	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), ACTR3(1), DAG1(3), DGKA(1), GCA(1), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), MAPK1(1), PAK1(2), PDE3A(2), PDE3B(2), PI3(1), PIK3C2G(3), PIK3CA(6), PIK3CD(1), PIK3R1(2), RIPK3(1)	20586960	44	42	42	11	3	10	5	18	8	0	0.359	1.000	1.000
473	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(3), ESR2(2), HNF4A(3), NPM1(2), NR1D2(1), NR2E1(2), NR2F1(2), NR2F6(1), NR3C1(2), PPARG(1), RARG(1), ROR1(1), RORA(2), RORC(1), RXRA(2), RXRB(1), THRA(1)	16900624	28	28	28	9	3	6	5	11	3	0	0.690	1.000	1.000
474	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT2(1), AKT3(1), FCER1A(1), GRB2(1), LCP2(1), LYN(3), MAP2K2(1), MAP2K3(1), MAP2K7(2), MAPK1(1), MAPK10(1), MAPK14(1), NRAS(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PRKCA(1), PRKCD(2), PRKCE(2), RAC2(1), RAF1(3), SOS1(2), SOS2(1), TNF(1), VAV1(3), VAV3(1)	30091508	56	47	54	11	7	10	4	23	12	0	0.138	1.000	1.000
475	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	MAP2K7(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK8IP1(1), NFKB2(2), NFKBIA(1), NFKBIL1(1), PIK3CA(6), PIK3CD(1), PIK3R1(2), TRAF5(1)	14859966	20	17	18	9	4	5	1	7	3	0	0.846	1.000	1.000
476	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT4(1), B3GNT1(1), B3GNT2(1), B4GALT1(2), B4GALT2(1), FUT4(2), FUT5(1), FUT6(1), GBGT1(1), GCNT2(2), PIGK(1), PIGM(1), PIGU(1), ST3GAL4(1), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA5(2)	20613005	25	20	25	7	0	6	0	11	8	0	0.702	1.000	1.000
477	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(1), AKT3(1), BCR(2), CD81(1), CR2(1), DAG1(3), FLOT1(1), GRB2(1), ITPR1(6), ITPR2(5), ITPR3(3), LYN(3), MAP4K1(1), MAPK1(1), NFATC2(1), PIK3CA(6), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(2), PPP3CB(1), PTPRC(1), RAF1(3), SOS1(2), SOS2(1), VAV1(3)	30981930	54	49	52	12	4	10	5	24	11	0	0.220	1.000	1.000
478	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(5), ATR(2), BRCA1(3), BRCA2(3), CHEK1(1), CHEK2(1), FANCA(2), MRE11A(2), TREX1(1)	18106260	20	20	20	9	0	3	3	10	4	0	0.933	1.000	1.000
479	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), CAMK2A(1), CAMK2B(2), CAMK2D(1), CLCA1(1), CNGA3(1), CNGB1(2), GUCA1B(1), PDE1C(2), PRKACG(1), PRKG1(2), PRKG2(2), PRKX(1)	12962075	19	19	19	9	1	6	0	11	1	0	0.821	1.000	1.000
480	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT2(1), AKT3(1), BCL10(1), CARD11(1), CD81(1), CR2(1), IFITM1(1), IKBKB(1), LYN(3), MALT1(1), NFAT5(2), NFATC2(1), NFATC3(3), NFKB2(2), NFKBIA(1), NRAS(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLCG2(1), PPP3CB(1), RAC2(1), RASGRP3(1), VAV1(3), VAV3(1)	31659210	48	42	46	10	5	6	6	23	8	0	0.240	1.000	1.000
481	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK2(1), CLK3(1), CLK4(5), COL2A1(1), CPSF2(1), CPSF3(1), CSTF1(1), CSTF2T(1), DDX20(4), DHX15(1), DHX16(2), DHX38(3), DHX8(3), DHX9(4), DICER1(2), METTL3(2), NCBP2(1), NUDT21(1), NXF1(4), PABPN1(1), POLR2A(1), PPM1G(1), PRPF18(3), PRPF4B(2), PRPF8(4), PTBP2(1), RBM17(1), RBM5(2), RNGTT(1), RNMT(1), SF3A1(2), SF3A3(1), SF3B1(7), SF3B2(2), SNRPA1(1), SNRPE(1), SNURF(1), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(3), U2AF2(2), XRN2(1)	44592287	83	71	83	15	4	11	13	36	19	0	0.106	1.000	1.000
482	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(1), AKT3(1), BCR(2), DAG1(3), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(1), LYN(3), MAP2K2(1), MAPK1(1), NFAT5(2), NFKB2(2), NFKBIA(1), NFKBIL1(1), PI3(1), PIK3CA(6), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(2), RAF1(3), SOS1(2), SOS2(1), VAV1(3)	22375624	44	38	42	11	4	8	3	21	8	0	0.365	1.000	1.000
483	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(1), AKT3(1), ASAH1(1), BRAF(4), DAG1(3), DRD2(1), EGFR(1), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), KCNJ3(1), MAPK1(1), PI3(1), PIK3CB(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), RAF1(3), RGS20(1), SOS1(2), SOS2(1), STAT3(1), TERF2IP(1)	24651714	51	49	50	13	4	8	9	13	17	0	0.286	1.000	1.000
484	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH6(2), ALDH1A3(1), AOC2(2), COMT(1), DCT(1), ECH1(1), ESCO1(2), GOT2(1), HPD(1), MAOA(1), MAOB(3), METTL2B(1), PNPLA3(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), TAT(1), TYRP1(2)	25003055	28	26	28	8	2	4	3	13	6	0	0.522	1.000	1.000
485	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(1), BMPR1A(2), BMPR2(1), CDKL2(3), CLK1(1), CLK2(1), CLK4(5), COL4A3BP(2), CSNK2A1(2), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), INPP4A(1), INPP4B(1), INPPL1(2), ITPKA(1), ITPKB(1), MAP3K10(1), NEK1(1), NEK3(1), OCRL(1), PAK4(3), PIK3C2A(5), PIK3C2B(2), PIK3C2G(3), PIK3CA(6), PIK3CB(2), PIK3CG(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1), PLK3(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKG1(2), RAF1(3), RPS6KA3(1), RPS6KA4(1), STK11(2), TGFBR1(1), VRK1(1)	48033757	94	80	92	18	5	15	14	31	29	0	0.0716	1.000	1.000
486	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT2(1), AKT3(1), BCL10(1), CARD11(1), CBLB(2), CBLC(1), CDK4(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(1), IL2(1), ITK(1), LCP2(1), MALT1(1), MAP3K8(1), NFAT5(2), NFATC2(1), NFATC3(3), NFKB2(2), NFKBIA(1), NRAS(2), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PPP3CB(1), PTPRC(1), RASGRP1(1), SOS1(2), SOS2(1), TNF(1), VAV1(3), VAV3(1), ZAP70(1)	42868962	66	55	64	12	6	10	9	27	14	0	0.0853	1.000	1.000
487	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(4), DCK(1), DPYD(1), DPYS(1), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(2), ENTPD8(1), NME7(1), NT5C(1), NT5C1A(1), NT5C1B(1), NT5M(1), NUDT2(1), PNPT1(4), POLA1(2), POLD1(2), POLD2(1), POLE(1), POLR1A(5), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLR3A(3), POLR3G(1), POLR3GL(1), POLR3H(1), RFC5(1), RRM1(2), TK2(1), TXNRD1(1), UMPS(2), UPB1(1), UPP1(1), UPP2(1), UPRT(1)	34343580	61	54	61	13	4	6	10	20	21	0	0.315	1.000	1.000
488	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), ATP8A1(1), C3AR1(3), CCKAR(1), CCKBR(2), CCR10(1), CCR2(1), CCR3(1), CCR5(1), CCR7(1), CXCR6(2), GRPR(1), LHCGR(1), NPY1R(1), NPY2R(2), OPRM1(1), SSTR1(2), TAC4(1), TACR2(1), TSHR(1)	21737294	26	24	26	9	1	4	3	14	4	0	0.766	1.000	1.000
489	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	APC(3), ASAH1(1), BRAF(4), DAG1(3), EGFR(1), GNAI1(1), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), KCNJ3(1), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(2), PIK3CA(6), PIK3CD(1), PIK3R1(2), RAF1(3)	21875636	47	45	44	13	3	7	7	18	12	0	0.545	1.000	1.000
490	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	BID(1), BRAF(4), FASLG(2), GRB2(1), HLA-A(1), HLA-B(1), HLA-C(3), ICAM1(1), IFNA2(2), IFNAR1(1), IFNG(2), IFNGR1(1), ITGAL(1), ITGB2(1), KLRC3(1), KLRK1(3), LCP2(1), MAP2K2(1), MAPK1(1), MICA(1), NFAT5(2), NFATC2(1), NFATC3(3), NRAS(2), PAK1(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLCG2(1), PPP3CB(1), PRKCA(1), PRKCG(2), PTK2B(1), RAC2(1), RAF1(3), SH3BP2(1), SHC2(1), SHC4(1), SOS1(2), SOS2(1), TNF(1), TNFRSF10D(1), TNFSF10(3), ULBP1(1), VAV1(3), VAV3(1), ZAP70(1)	47905106	84	65	81	16	6	13	12	31	21	1	0.0938	1.000	1.000
491	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG10B(1), ALG11(1), ALG14(1), ALG2(1), ALG6(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT6(2), B4GALT1(2), B4GALT2(1), B4GALT5(1), CHST13(1), CHST2(3), CHST3(1), CHSY1(1), DPAGT1(2), EXT2(2), EXTL1(1), FUT11(1), GALNT10(1), GALNT11(1), GALNT2(1), GALNT4(2), GALNT5(1), GALNT6(3), GALNT7(3), GCNT3(2), HS2ST1(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), MAN1B1(1), MAN1C1(2), MAN2A1(2), MGAT4B(1), MGAT5(1), MGAT5B(1), NDST1(1), NDST4(2), OGT(2), RPN1(2), RPN2(1), ST3GAL4(1), ST6GAL1(1), XYLT1(1)	46819146	65	56	65	12	3	11	8	19	24	0	0.163	1.000	1.000
492	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	ELK1(1), FCER1A(1), GRB2(1), LYN(3), MAP2K7(2), MAP3K1(3), MAPK1(1), NFATC2(1), NFATC3(3), PIK3CA(6), PIK3R1(2), PLA2G4A(1), PPP3CB(1), RAF1(3), SOS1(2), VAV1(3)	18030994	34	30	32	10	4	8	1	13	8	0	0.652	1.000	1.000
493	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(1), INPP4B(1), INPPL1(2), ITPKA(1), ITPKB(1), OCRL(1), PIK3C2A(5), PIK3C2B(2), PIK3C2G(3), PIK3CA(6), PIK3CB(2), PIK3CG(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1)	18958427	36	34	34	10	3	8	5	10	10	0	0.493	1.000	1.000
494	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(4), ACADL(3), ACADM(2), ACOX1(1), ACOX2(3), ACOX3(3), ACSL6(1), ANGPTL4(1), AQP7(1), CPT1A(1), CPT1B(1), CPT1C(1), CYP27A1(1), CYP4A11(2), CYP7A1(1), EHHADH(1), GK(1), HMGCS2(2), LPL(4), PCK1(5), PCK2(1), PPARG(1), RXRA(2), RXRB(1), SCP2(1), SORBS1(1), UBC(2)	27725096	48	40	48	13	2	13	8	16	9	0	0.410	1.000	1.000
495	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	BRAF(4), CACNA1A(5), CRH(1), GNA13(2), GNAI1(1), GNAI2(2), GNAZ(2), GRIA1(3), GRIA2(1), GRID2(2), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(2), GUCY2D(1), IGF1R(2), ITPR1(6), ITPR2(5), ITPR3(3), LYN(3), MAP2K2(1), MAPK1(1), NOS1(1), NOS3(1), NPR1(1), NPR2(3), NRAS(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PPP2R1A(2), PPP2R2A(2), PPP2R2C(1), PRKCA(1), PRKCG(2), PRKG1(2), PRKG2(2), RAF1(3), RYR1(7)	46809833	93	76	92	20	11	10	11	38	23	0	0.162	1.000	1.000
496	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(1), ABL2(1), AKT2(1), AKT3(1), BRAF(4), CAMK2A(1), CAMK2B(2), CAMK2D(1), CBLB(2), CBLC(1), EGF(1), EGFR(1), ELK1(1), ERBB2(3), ERBB3(2), ERBB4(4), GRB2(1), MAP2K2(1), MAP2K7(2), MAPK1(1), MAPK10(1), NRAS(2), NRG1(3), NRG2(1), NRG3(3), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLCG2(1), PRKCA(1), PRKCG(2), PTK2(1), RAF1(3), RPS6KB2(1), SHC2(1), SHC4(1), SOS1(2), SOS2(1), STAT5A(2), STAT5B(1)	43607763	84	66	80	18	6	14	10	35	19	0	0.102	1.000	1.000
497	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	85	ANPEP(5), CD1A(1), CD1C(2), CD1D(1), CD33(1), CD5(1), CD7(2), CD9(1), CR1(3), CR2(1), CSF1R(3), CSF2RA(1), CSF3R(1), FCER2(1), FCGR1A(1), FLT3(1), IL1R1(1), IL1R2(1), IL4R(2), IL5RA(1), IL7R(1), IL9R(1), ITGA1(3), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGAM(3), ITGB3(3), MME(1), TFRC(2), THPO(1), TNF(1)	35359469	56	47	56	15	5	6	7	21	17	0	0.552	1.000	1.000
498	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH6(2), AGK(2), AGPAT1(1), AGPAT2(1), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), CEL(1), DAK(1), DGAT2(1), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), GK(1), GPAM(2), LCT(1), LIPA(1), LPL(4), PNPLA3(1), PPAP2B(1)	25005034	39	37	39	12	3	4	6	14	12	0	0.627	1.000	1.000
499	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(1), ACSL6(1), AKT2(1), AKT3(1), CAMKK1(3), CPT1A(1), CPT1B(1), CPT1C(1), IKBKB(1), IRS1(2), IRS2(3), JAK1(2), JAK2(1), JAK3(1), LEPR(1), MAPK10(1), NFKB2(2), NFKBIA(1), PCK1(5), PCK2(1), POMC(1), PRKAA1(1), PRKAG1(1), PRKAG2(3), RELA(2), RXRA(2), RXRB(1), SLC2A4(2), SOCS3(1), STAT3(1), STK11(2), TNF(1), TNFRSF1B(2)	35467157	51	46	51	13	6	7	11	15	12	0	0.350	1.000	1.000
500	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT2(1), AKT3(1), CD40(1), CD86(2), IFNA2(2), IFNAR1(1), IKBKB(1), IKBKE(1), IRF5(1), IRF7(1), MAP2K2(1), MAP2K3(1), MAP2K7(2), MAP3K7(1), MAP3K8(1), MAPK1(1), MAPK10(1), MAPK14(1), NFKB2(2), NFKBIA(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), RELA(2), RIPK1(1), STAT1(2), TBK1(1), TLR1(2), TLR2(1), TLR3(2), TLR5(3), TLR6(1), TLR7(1), TNF(1)	37932952	58	51	56	14	6	8	7	20	17	0	0.384	1.000	1.000
501	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(1), ACVR2A(4), AMH(2), AMHR2(2), BMP4(1), BMP7(1), BMP8A(1), BMPR1A(2), BMPR2(1), CHRD(1), CREBBP(8), CUL1(2), E2F5(1), EP300(5), IFNG(2), INHBB(1), INHBE(1), LTBP1(5), MAPK1(1), NODAL(1), PPP2R1A(2), PPP2R2A(2), PPP2R2C(1), ROCK1(2), ROCK2(1), RPS6KB2(1), SMAD1(1), SMAD2(1), SMAD4(3), SMAD7(1), SMAD9(1), SMURF2(1), TGFBR1(1), THBS1(5), THBS2(2), THBS3(1), THBS4(2), TNF(1), ZFYVE16(2), ZFYVE9(2)	41966205	76	64	76	19	6	8	16	25	21	0	0.357	1.000	1.000
502	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT2(1), AKT3(1), CDKN2A(1), CREB1(1), ERBB4(4), F2RL2(1), GRB2(1), IGFBP1(1), INPPL1(2), IRS1(2), IRS2(3), NOLC1(2), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PARD3(2), PIK3CA(6), PIK3CD(1), PPP1R13B(2), PREX1(2), PTK2(1), PTPN1(1), RPS6KA3(1), SFN(1), SLC2A4(2), SOS1(2), SOS2(1), TSC1(2), TSC2(6)	30865131	58	49	56	16	6	14	6	18	14	0	0.252	1.000	1.000
503	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), ALG6(1), CCKBR(2), CCR2(1), CCR3(1), CCR5(1), CELSR1(3), CELSR2(3), CELSR3(3), CHRM2(1), CHRM3(1), CIDEB(1), DRD4(1), F2R(1), GPR116(2), GPR133(3), GPR18(2), GRM1(1), GRPR(1), LPHN2(1), LPHN3(2), LTB4R2(1), OR2M4(1), PTGFR(2), SMO(1), TSHR(1), VN1R1(1)	27973261	40	34	40	12	2	4	10	18	6	0	0.509	1.000	1.000
504	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTB(3), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(1), BIRC2(1), BIRC3(2), BRAF(4), CAPN2(1), CAV2(1), CCND3(1), CHAD(3), COL11A1(3), COL11A2(1), COL1A2(3), COL2A1(1), COL4A1(2), COL4A2(3), COL4A6(2), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(4), COL6A3(5), COL6A6(4), CTNNB1(2), DIAPH1(2), DOCK1(1), EGF(1), EGFR(1), ELK1(1), ERBB2(3), FARP2(1), FIGF(1), FLNB(2), FLNC(1), FLT1(1), FN1(4), GRB2(1), HGF(1), IGF1R(2), ITGA1(3), ITGA10(3), ITGA11(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGAV(1), ITGB1(1), ITGB3(3), ITGB4(4), ITGB5(4), ITGB7(1), ITGB8(2), KDR(1), LAMA3(5), LAMA4(1), LAMA5(1), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(2), LAMC3(2), MAPK1(1), MAPK10(1), MYLK(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PARVG(1), PDGFRA(1), PDGFRB(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CC(1), PPP1R12A(2), PRKCA(1), PRKCG(2), PTK2(1), PXN(1), RAC2(1), RAF1(3), RAPGEF1(2), RELN(3), ROCK1(2), ROCK2(1), SHC2(1), SHC4(1), SOS1(2), SOS2(1), THBS1(5), THBS2(2), THBS3(1), THBS4(2), TLN1(6), TLN2(4), TNC(1), TNN(1), TNR(1), TNXB(5), VAV1(3), VAV3(1), VCL(1), VWF(2)	156274656	233	151	229	70	18	41	28	89	55	2	0.521	1.000	1.000
505	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ABI2(1), ACTN4(1), APC(3), APC2(1), ARHGEF12(2), ARHGEF4(2), ARHGEF6(1), ARHGEF7(2), BAIAP2(2), BRAF(4), CFL2(1), CHRM1(2), CHRM2(1), CHRM3(1), CYFIP1(1), CYFIP2(1), DIAPH1(2), DIAPH2(1), DIAPH3(2), DOCK1(1), EGF(1), EGFR(1), EZR(1), F2(2), F2R(1), FGD3(1), FGF1(1), FGF12(1), FGF19(1), FGF3(1), FGF4(1), FGF5(1), FGF6(1), FGF7(1), FGFR1(1), FGFR3(6), FGFR4(2), FN1(4), GNA13(2), GNG12(1), GSN(1), INS(1), IQGAP1(1), IQGAP2(3), IQGAP3(2), ITGA1(3), ITGA10(3), ITGA11(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGAD(2), ITGAE(2), ITGAL(1), ITGAM(3), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(1), ITGB3(3), ITGB4(4), ITGB5(4), ITGB7(1), ITGB8(2), LIMK1(1), LIMK2(1), MAP2K2(1), MAPK1(1), MSN(1), MYH10(4), MYH14(3), MYH9(4), MYLK(1), NCKAP1(1), NCKAP1L(3), NRAS(2), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PDGFRA(1), PDGFRB(2), PFN1(1), PFN3(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PIP4K2A(1), PIP5K1C(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(1), PTK2(1), PXN(1), RAC2(1), RAF1(3), RDX(1), ROCK1(2), ROCK2(1), SCIN(3), SOS1(2), SOS2(1), SSH1(2), SSH2(5), TIAM1(1), TIAM2(1), VAV1(3), VAV3(1), VCL(1), WASF1(1), WASL(2)	117364705	212	142	208	53	18	28	28	93	45	0	0.141	1.000	1.000
506	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY2(1), ADCY3(2), ADCY4(1), ADCY7(1), ADCY8(3), ADCY9(3), ADORA2A(2), ATP2A1(1), ATP2A2(1), ATP2B1(1), ATP2B2(1), ATP2B3(2), CACNA1A(5), CACNA1B(4), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1G(4), CACNA1H(5), CACNA1I(1), CACNA1S(5), CAMK2A(1), CAMK2B(2), CAMK2D(1), CCKAR(1), CCKBR(2), CHRM1(2), CHRM2(1), CHRM3(1), EGFR(1), ERBB2(3), ERBB3(2), ERBB4(4), F2R(1), GNA14(1), GRIN2A(4), GRIN2D(2), GRM1(1), GRM5(1), GRPR(1), HTR2B(2), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), LHCGR(1), LTB4R2(1), MYLK(1), NOS1(1), NOS3(1), P2RX1(1), P2RX2(1), P2RX7(1), PDE1B(1), PDE1C(2), PDGFRA(1), PDGFRB(2), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1), PLCZ1(2), PPID(1), PPP3CB(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), PTGER3(2), PTGFR(2), PTK2B(1), RYR1(7), RYR2(5), RYR3(6), SLC25A5(1), SLC8A1(3), SLC8A2(1), SLC8A3(1), SPHK1(1), SPHK2(1), TACR2(1), TRPC1(1), VDAC2(1), VDAC3(2)	115532110	183	131	181	56	16	33	26	62	46	0	0.374	1.000	1.000
507	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(1), AKT2(1), AKT3(1), ARRB1(1), ATF2(1), BDNF(1), BRAF(4), CACNA1A(5), CACNA1B(4), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1G(4), CACNA1H(5), CACNA1I(1), CACNA1S(5), CACNA2D1(1), CACNA2D2(1), CACNA2D3(1), CACNA2D4(3), CACNB1(2), CACNG2(3), CACNG7(1), CACNG8(1), DAXX(1), DUSP6(2), DUSP7(1), ECSIT(1), EGF(1), EGFR(1), ELK1(1), FASLG(2), FGF1(1), FGF12(1), FGF19(1), FGF3(1), FGF4(1), FGF5(1), FGF6(1), FGF7(1), FGFR1(1), FGFR3(6), FGFR4(2), FLNB(2), FLNC(1), GADD45B(2), GNG12(1), GRB2(1), IKBKB(1), IL1R1(1), IL1R2(1), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K3(1), MAP3K4(3), MAP3K6(3), MAP3K7(1), MAP3K8(1), MAP4K1(1), MAP4K2(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK8IP1(1), MAPKAPK2(1), MAPT(1), MEF2C(1), MKNK2(1), NF1(5), NFATC2(1), NFKB2(2), NRAS(2), NTRK1(1), NTRK2(2), PAK1(2), PDGFRA(1), PDGFRB(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PPM1A(1), PPP3CB(1), PPP5C(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), PTPRR(3), RAC2(1), RAF1(3), RASA1(2), RASGRF1(6), RASGRP1(1), RASGRP3(1), RASGRP4(1), RPS6KA3(1), RPS6KA4(1), RPS6KA5(1), SOS1(2), SOS2(1), STMN1(1), TAOK2(1), TAOK3(2), TGFBR1(1), TNF(1), ZAK(1)	122453090	188	125	185	50	19	19	32	70	47	1	0.379	1.000	1.000
508	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(3), CHAD(3), COL11A1(3), COL11A2(1), COL17A1(2), COL1A2(3), COL2A1(1), COL4A1(2), COL4A2(3), COL4A6(2), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(4), COL6A3(5), COL6A6(4), DES(1), DSC2(2), DSC3(1), DSG1(1), DSG3(1), DSG4(1), FN1(4), GJA3(1), GJA4(1), GJB3(2), GJB7(1), GJC1(1), GJC3(1), GJD3(1), ITGA6(3), ITGB4(4), KRT10(3), KRT13(3), KRT15(1), KRT17(1), KRT19(1), KRT23(2), KRT24(1), KRT25(1), KRT27(3), KRT3(5), KRT32(1), KRT33A(1), KRT33B(1), KRT37(1), KRT38(1), KRT4(1), KRT5(1), KRT6A(1), KRT72(2), KRT73(1), KRT76(1), KRT82(1), KRT83(1), KRT84(1), KRT85(2), KRT86(2), KRT9(2), LAMA3(5), LAMA4(1), LAMA5(1), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(2), LAMC3(2), LMNA(2), LMNB1(1), LMNB2(1), PRPH(1), RELN(3), THBS1(5), THBS2(2), THBS3(1), THBS4(2), TNC(1), TNN(1), TNR(1), TNXB(5), VIM(1), VWF(2)	105751649	165	123	161	61	16	30	21	61	35	2	0.891	1.000	1.000
509	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(2), CHAD(3), COL11A1(3), COL11A2(1), COL1A2(3), COL2A1(1), COL4A1(2), COL4A2(3), COL4A6(2), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(4), COL6A3(5), COL6A6(4), DAG1(3), FN1(4), HSPG2(4), ITGA1(3), ITGA10(3), ITGA11(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGAV(1), ITGB1(1), ITGB3(3), ITGB4(4), ITGB5(4), ITGB7(1), ITGB8(2), LAMA3(5), LAMA4(1), LAMA5(1), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(2), LAMC3(2), RELN(3), SDC4(2), SV2A(1), SV2B(2), SV2C(2), THBS1(5), THBS2(2), THBS3(1), THBS4(2), TNC(1), TNN(1), TNR(1), TNXB(5), VWF(2)	95705615	140	110	140	45	8	26	16	57	31	2	0.671	1.000	1.000
510	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), ARRB1(1), ATP1A4(1), ATP2A2(1), ATP2B1(1), ATP2B2(1), ATP2B3(2), CACNA1A(5), CACNA1B(4), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1S(5), CACNB1(2), CALR(1), CAMK1(2), CAMK2A(1), CAMK2B(2), CAMK2D(1), CHRM1(2), CHRM2(1), CHRM3(1), GJA4(1), GJB3(2), GNAI2(2), GNAZ(2), GNB1(1), GNB5(1), GNG12(1), GNG13(1), GRK5(1), ITPR1(6), ITPR2(5), ITPR3(3), KCNB1(2), KCNJ3(1), MIB1(1), NME7(1), PLCB3(2), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), RGS1(1), RGS14(2), RGS20(1), RGS3(2), RGS6(1), RGS7(2), RYR1(7), RYR2(5), RYR3(6), SFN(1), SLC8A1(3), SLC8A3(1), USP5(2)	79640686	137	109	136	51	16	15	19	50	37	0	0.870	1.000	1.000
511	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(3), ACTN4(1), AKT2(1), AKT3(1), AMOTL1(2), ASH1L(4), CDK4(1), CGN(1), CLDN11(2), CLDN16(1), CLDN18(1), CLDN3(1), CRB3(1), CSNK2A1(2), CTNNA1(5), CTNNA2(1), CTNNA3(1), CTNNB1(2), EPB41L1(3), EPB41L2(1), EPB41L3(4), EXOC4(2), GNAI1(1), GNAI2(2), INADL(3), JAM3(1), LLGL1(1), MAGI1(2), MAGI3(1), MLLT4(4), MYH1(2), MYH10(4), MYH11(1), MYH13(3), MYH14(3), MYH15(3), MYH3(2), MYH4(5), MYH6(3), MYH7(6), MYH7B(2), MYH8(3), MYH9(4), NRAS(2), PARD3(2), PPP2R1A(2), PPP2R2A(2), PPP2R2C(1), PPP2R3A(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCI(3), SPTAN1(3), SYMPK(2), TJAP1(2), TJP1(2), TJP2(2), TJP3(1), YES1(1), ZAK(1)	80785336	131	103	130	47	7	11	31	50	32	0	0.954	1.000	1.000
512	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(3), APC2(1), AXIN1(3), AXIN2(2), BTRC(2), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CCND3(1), CER1(1), CHD8(5), CREBBP(8), CSNK1E(3), CSNK2A1(2), CTBP1(1), CTNNB1(2), CUL1(2), DAAM1(1), DAAM2(2), DVL3(1), EP300(5), FZD1(1), FZD2(1), FZD4(1), FZD5(2), FZD7(3), FZD8(2), LEF1(1), LRP5(3), LRP6(6), MAP3K7(1), MAPK10(1), NFAT5(2), NFATC2(1), NFATC3(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PORCN(1), PPP2R1A(2), PPP2R2A(2), PPP2R2C(1), PPP3CB(1), PRICKLE1(2), PRICKLE2(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(1), RAC2(1), ROCK1(2), ROCK2(1), RUVBL1(1), SENP2(1), SMAD2(1), SMAD4(3), SOX17(1), TBL1X(2), TBL1XR1(1), TCF7L1(2), VANGL1(1), WIF1(1), WNT10A(2), WNT2(1), WNT2B(1), WNT7A(1), WNT7B(1), WNT8B(1), WNT9B(2)	67849512	131	102	131	36	14	18	20	45	34	0	0.400	1.000	1.000
513	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADORA2A(2), ADORA3(1), ADRA2A(1), AGTR2(1), C3AR1(3), CALCR(3), CALCRL(2), CCKAR(1), CCKBR(2), CHRM1(2), CHRM2(1), CHRM3(1), CRHR2(1), DRD2(1), DRD4(1), DRD5(1), F2(2), F2R(1), F2RL2(1), GABBR1(2), GABRA3(1), GABRB2(2), GABRB3(2), GABRD(1), GABRG1(1), GABRG2(3), GABRG3(3), GABRP(1), GABRQ(2), GIPR(1), GLP2R(2), GLRA1(2), GLRB(1), GPR50(1), GPR83(1), GRIA1(3), GRIA2(1), GRID1(1), GRID2(2), GRIK3(1), GRIK4(1), GRIK5(1), GRIN2A(4), GRIN2B(1), GRIN2D(2), GRIN3A(2), GRM1(1), GRM2(1), GRM3(2), GRM4(2), GRM5(1), GRM6(1), GRPR(1), HCRTR1(1), HCRTR2(4), HTR1A(1), HTR1B(1), HTR2B(2), LEPR(1), LHCGR(1), LTB4R2(1), MAS1(1), MCHR1(1), NPBWR2(1), NPY1R(1), NPY2R(2), NR3C1(2), OPRM1(1), P2RX1(1), P2RX2(1), P2RX7(1), P2RY1(2), P2RY2(1), P2RY4(1), P2RY8(1), PARD3(2), PRLR(1), PRSS3(3), PTGDR(1), PTGER3(2), PTGFR(2), RXFP1(2), SSTR1(2), TACR2(1), THRA(1), TRPV1(2), TSHR(1)	93144676	131	98	130	33	13	22	23	49	23	1	0.0859	1.000	1.000
514	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(1), ABLIM1(1), ARHGEF12(2), CFL2(1), DCC(3), DPYSL2(1), EFNA1(3), EFNA2(1), EFNA5(1), EPHA2(1), EPHA3(4), EPHA4(2), EPHA5(3), EPHA6(2), EPHA7(1), EPHB1(1), EPHB2(1), EPHB3(1), EPHB4(2), EPHB6(2), FES(1), GNAI1(1), GNAI2(2), ITGB1(1), LIMK1(1), LIMK2(1), LRRC4C(2), MAPK1(1), NFAT5(2), NFATC2(1), NFATC3(3), NGEF(1), NRAS(2), NTN1(1), NTNG1(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PLXNA2(6), PLXNA3(2), PLXNB1(3), PLXNB2(4), PLXNB3(1), PLXNC1(1), PPP3CB(1), PTK2(1), RAC2(1), RASA1(2), RGS3(2), ROBO1(3), ROBO2(2), ROCK1(2), ROCK2(1), SEMA3A(1), SEMA3D(1), SEMA3E(2), SEMA3F(3), SEMA4A(1), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA4G(1), SEMA5A(1), SEMA6A(2), SEMA7A(1), SLIT2(1), SLIT3(2), SRGAP1(4), SRGAP3(1), UNC5A(2), UNC5B(1), UNC5C(2)	82024362	125	98	125	49	8	11	13	60	33	0	0.991	1.000	1.000
515	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(2), ACACB(1), AKT2(1), AKT3(1), BRAF(4), CBLB(2), CBLC(1), ELK1(1), EXOC7(4), FASN(4), FLOT1(1), FOXO1(1), GCK(1), GRB2(1), GYS2(1), IKBKB(1), INS(1), IRS1(2), IRS2(3), MAP2K2(1), MAPK1(1), MAPK10(1), MKNK2(1), NRAS(2), PCK1(5), PCK2(1), PDE3A(2), PDE3B(2), PFKL(1), PFKP(1), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PPP1CC(1), PPP1R3A(1), PRKAA1(1), PRKACG(1), PRKAG1(1), PRKAG2(3), PRKAR1A(1), PRKAR2B(2), PRKCI(3), PRKX(1), PTPN1(1), PTPRF(1), PYGB(1), PYGM(1), RAF1(3), RAPGEF1(2), RHEB(1), RHOQ(1), RPS6KB2(1), SHC2(1), SHC4(1), SLC2A4(2), SOCS1(1), SOCS3(1), SORBS1(1), SOS1(2), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(6)	68296056	125	96	122	32	11	23	21	48	22	0	0.124	1.000	1.000
516	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1B(1), ACVR2A(4), AMH(2), AMHR2(2), BMP7(1), BMPR1A(2), BMPR2(1), CCL27(1), CCR2(1), CCR3(1), CCR5(1), CCR7(1), CCR9(2), CD27(1), CD40(1), CNTF(2), CSF1R(3), CSF2RA(1), CSF2RB(3), CSF3R(1), CX3CL1(2), CXCR6(2), EGF(1), EGFR(1), FASLG(2), FLT1(1), FLT3(1), FLT4(4), HGF(1), IFNA2(2), IFNAR1(1), IFNG(2), IFNGR1(1), IFNK(1), IL10RA(3), IL10RB(1), IL12RB2(1), IL15RA(1), IL17RA(1), IL17RB(1), IL18(1), IL1R1(1), IL1R2(1), IL2(1), IL21R(3), IL4R(2), IL5RA(1), IL6ST(2), IL7R(1), IL9(1), IL9R(1), INHBB(1), INHBE(1), KDR(1), LEPR(1), LIF(1), LIFR(2), LTBR(1), NGFR(1), PDGFRA(1), PDGFRB(2), PLEKHO2(1), PRLR(1), TGFBR1(1), TNF(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF14(1), TNFRSF19(1), TNFRSF1B(2), TNFRSF21(1), TNFRSF8(1), TNFSF10(3), TNFSF15(1), TNFSF8(2)	73926331	108	89	108	27	10	14	16	45	23	0	0.368	1.000	1.000
517	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), ARRB1(1), ATF2(1), ATP2A2(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CRH(1), GABPB2(1), GBA2(3), GNB1(1), GNB5(1), GNG12(1), GNG13(1), GRK5(1), GUCA2A(1), IGFBP1(1), IGFBP2(1), IGFBP6(1), ITPR1(6), ITPR2(5), ITPR3(3), MIB1(1), MYL4(1), NOS1(1), NOS3(1), OXT(1), PLCB3(2), PLCD1(2), PLCG2(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PRKCD(2), PRKCE(2), RGS1(1), RGS14(2), RGS20(1), RGS3(2), RGS6(1), RGS7(2), RYR1(7), RYR2(5), RYR3(6), SFN(1), SLC8A1(3), TNXB(5), USP5(2)	73754844	106	89	106	40	11	17	15	37	26	0	0.859	1.000	1.000
518	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), ADK(2), ADSL(1), ADSSL1(2), AK7(2), AMPD2(1), ATIC(1), DCK(1), ENPP1(2), ENPP3(1), ENTPD4(2), ENTPD5(1), ENTPD6(2), ENTPD8(1), GART(2), GDA(1), GMPR(1), GMPS(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(2), GUCY2D(1), NME7(1), NPR1(1), NPR2(3), NT5C(1), NT5C1A(1), NT5C1B(1), NT5M(1), NUDT2(1), NUDT5(1), PAPSS1(1), PAPSS2(2), PDE11A(1), PDE1C(2), PDE3B(2), PDE4A(1), PDE7B(1), PDE8B(1), PDE9A(2), PFAS(2), PNPT1(4), POLA1(2), POLD1(2), POLD2(1), POLE(1), POLR1A(5), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLR3A(3), POLR3G(1), POLR3GL(1), POLR3H(1), PPAT(1), PRPS2(1), PRUNE(1), RFC5(1), RRM1(2), XDH(1)	69293580	108	88	108	30	11	17	10	41	29	0	0.545	1.000	1.000
519	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	AKT2(1), AKT3(1), CBLB(2), CBLC(1), CCND3(1), CISH(2), CNTF(2), CREBBP(8), CSF2RA(1), CSF2RB(3), CSF3R(1), EP300(5), GRB2(1), IFNA2(2), IFNAR1(1), IFNG(2), IFNGR1(1), IFNK(1), IL10RA(3), IL10RB(1), IL12RB2(1), IL15RA(1), IL2(1), IL21R(3), IL4R(2), IL5RA(1), IL6ST(2), IL7R(1), IL9(1), IL9R(1), IRF9(1), JAK1(2), JAK2(1), JAK3(1), LEPR(1), LIF(1), LIFR(2), PIAS1(1), PIAS2(2), PIAS3(1), PIAS4(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PRLR(1), SOCS1(1), SOCS3(1), SOCS5(1), SOS1(2), SOS2(1), SPRED2(1), SPRY1(1), SPRY2(1), STAM(2), STAT1(2), STAT2(1), STAT3(1), STAT5A(2), STAT5B(1)	61485967	104	85	102	26	7	17	19	33	28	0	0.310	1.000	1.000
520	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTB(3), ACTN4(1), ACVR1B(1), BAIAP2(2), CDH1(2), CREBBP(8), CSNK2A1(2), CTNNA1(5), CTNNA2(1), CTNNA3(1), CTNNB1(2), EGFR(1), EP300(5), ERBB2(3), FARP2(1), FGFR1(1), IGF1R(2), IQGAP1(1), LEF1(1), LMO7(5), MAP3K7(1), MAPK1(1), MLLT4(4), PARD3(2), PTPN1(1), PTPRB(4), PTPRF(1), PTPRJ(4), PTPRM(6), PVRL3(2), RAC2(1), SMAD2(1), SMAD4(3), SNAI2(2), SORBS1(1), SSX2IP(2), TCF7L1(2), TGFBR1(1), TJP1(2), VCL(1), WASF1(1), WASL(2), YES1(1)	49379283	94	80	93	31	3	14	23	32	22	0	0.692	1.000	1.000
521	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM3(1), CD226(1), CD40(1), CD58(1), CD6(2), CD86(2), CDH1(2), CDH3(1), CDH4(1), CDH5(1), CLDN11(2), CLDN16(1), CLDN18(1), CLDN3(1), CNTN1(4), CNTN2(1), GLG1(3), HLA-A(1), HLA-B(1), HLA-C(3), HLA-DOB(1), HLA-DPB1(1), HLA-DQA2(1), ICAM1(1), ICOS(1), ITGA4(1), ITGA6(3), ITGA8(1), ITGAL(1), ITGAM(3), ITGAV(1), ITGB1(1), ITGB2(1), ITGB7(1), ITGB8(2), JAM3(1), MADCAM1(1), MAG(3), MPZL1(1), NCAM1(2), NCAM2(4), NEO1(4), NFASC(3), NLGN1(1), NLGN2(1), NRCAM(1), NRXN1(2), NRXN2(1), NRXN3(1), PTPRC(1), PTPRF(1), PTPRM(6), PVRL3(2), SDC4(2), SELE(1), SELL(1), VCAM1(1), VCAN(5)	62185657	97	77	97	31	5	10	11	45	26	0	0.717	1.000	1.000
522	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), ASIP(2), CAMK2A(1), CAMK2B(2), CAMK2D(1), CREB1(1), CREB3L1(2), CREB3L3(1), CREBBP(8), CTNNB1(2), DCT(1), DVL3(1), EP300(5), FZD1(1), FZD2(1), FZD4(1), FZD5(2), FZD7(3), FZD8(2), GNAI1(1), GNAI2(2), LEF1(1), MAP2K2(1), MAPK1(1), MITF(2), NRAS(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), POMC(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(3), TCF7L1(2), TYRP1(2), WNT10A(2), WNT2(1), WNT2B(1), WNT7A(1), WNT7B(1), WNT8B(1), WNT9B(2)	46032555	90	77	89	37	11	18	7	27	27	0	0.900	1.000	1.000
523	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(1), CAPN1(1), CAPN11(2), CAPN2(1), CAPN3(1), CAPN7(3), CAV2(1), DOCK1(1), GIT2(1), GRB2(1), ITGA10(3), ITGA11(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGAD(2), ITGAE(2), ITGAL(1), ITGAM(3), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(1), ITGB3(3), ITGB4(4), ITGB5(4), ITGB7(1), ITGB8(2), MAP2K2(1), MAP2K3(1), MAPK10(1), MAPK6(2), PAK1(2), PAK3(2), PAK4(3), PIK3R2(1), PTK2(1), PXN(1), RAC2(1), RAPGEF1(2), ROCK1(2), ROCK2(1), SORBS1(1), SOS1(2), TLN1(6), TNS1(5), VAV3(1), VCL(1)	57317312	96	76	96	30	3	12	10	42	29	0	0.673	1.000	1.000
524	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(1), ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADK(2), ADSL(1), AMPD2(1), ATIC(1), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), DCK(1), ENPP1(2), ENPP3(1), GART(2), GDA(1), GMPS(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(2), GUCY2D(1), NPR1(1), NPR2(3), NT5C(1), NT5M(1), NUDT2(1), PAPSS1(1), PAPSS2(2), PDE4A(1), PDE6B(2), PDE7B(1), PDE9A(2), PFAS(2), POLB(1), POLD1(2), POLD2(1), POLE(1), POLG(2), POLL(1), POLQ(3), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLRMT(2), PPAT(1), PRPS2(1), PRUNE(1), RRM1(2)	54216343	86	74	86	24	6	14	11	30	25	0	0.574	1.000	1.000
525	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), INPP4A(1), INPP4B(1), INPP5B(2), INPP5E(1), INPPL1(2), ITPK1(2), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), OCRL(1), PI4KA(2), PIK3C2A(5), PIK3C2B(2), PIK3C2G(3), PIK3C3(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PIP4K2A(1), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1), PLCZ1(2), PRKCA(1), PRKCG(2), SYNJ2(1)	52721615	85	73	83	27	6	14	12	30	23	0	0.642	1.000	1.000
526	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), DRD2(1), EGF(1), EGFR(1), GNAI1(1), GNAI2(2), GRB2(1), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(2), GUCY2D(1), HTR2B(2), ITPR1(6), ITPR2(5), ITPR3(3), MAP2K2(1), MAP2K5(2), MAPK1(1), NPR1(1), NPR2(3), NRAS(2), PDGFRA(1), PDGFRB(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKG1(2), PRKG2(2), PRKX(1), RAF1(3), SOS1(2), SOS2(1), TJP1(2), TUBA3D(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB1(1)	56069110	87	72	87	38	9	15	9	35	19	0	0.952	1.000	1.000
527	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), CACNA1C(3), CACNA1D(5), CACNA1S(5), CAMK2A(1), CAMK2B(2), CAMK2D(1), EGFR(1), ELK1(1), GRB2(1), ITPR1(6), ITPR2(5), ITPR3(3), MAP2K2(1), MAP2K3(1), MAP2K7(2), MAP3K1(3), MAP3K3(1), MAP3K4(3), MAPK1(1), MAPK10(1), MAPK14(1), NRAS(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLD1(1), PRKACG(1), PRKCA(1), PRKCD(2), PRKX(1), PTK2B(1), RAF1(3), SOS1(2), SOS2(1)	54187053	88	72	88	38	8	18	8	29	25	0	0.953	1.000	1.000
528	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY8(3), BRAF(4), CACNA1C(3), CAMK2A(1), CAMK2B(2), CAMK2D(1), CREBBP(8), EP300(5), GRIA1(3), GRIA2(1), GRIN2A(4), GRIN2B(1), GRIN2D(2), GRM1(1), GRM5(1), ITPR1(6), ITPR2(5), ITPR3(3), MAP2K2(1), MAPK1(1), NRAS(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PPP1CC(1), PPP1R12A(2), PPP3CB(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(3), RAPGEF3(1), RPS6KA3(1)	42255196	79	71	78	27	5	12	11	30	21	0	0.735	1.000	1.000
529	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(2), ABCA10(3), ABCA12(4), ABCA13(4), ABCA3(1), ABCA4(3), ABCA5(3), ABCA6(1), ABCA7(8), ABCA8(3), ABCB1(2), ABCB10(1), ABCB11(1), ABCB4(2), ABCB5(2), ABCB6(3), ABCB8(1), ABCB9(1), ABCC1(3), ABCC10(1), ABCC11(1), ABCC12(2), ABCC2(4), ABCC3(2), ABCC4(2), ABCC5(3), ABCC6(3), ABCC9(1), ABCD2(1), ABCD3(1), ABCD4(1), ABCG1(1), ABCG2(1), ABCG4(3), ABCG8(1), CFTR(1)	49963868	77	68	77	30	6	7	10	35	19	0	0.940	1.000	1.000
530	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	77	ABL1(1), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF6(1), ARHGEF7(2), BRAF(4), CDKN2A(1), CSE1L(3), DOCK1(1), EPHB2(1), GRB2(1), GRB7(2), ITGA1(3), ITGA10(3), ITGA11(1), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGB3BP(1), MAP2K7(2), MAPK1(1), MAPK10(1), MAPK8IP1(1), MYLK(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PIK3CA(6), PIK3CB(2), PLCG2(1), PTK2(1), RAF1(3), RALA(1), ROCK1(2), ROCK2(1), SOS1(2), SOS2(1), TERF2IP(1), TLN1(6), TLN2(4)	51516817	83	68	80	24	4	14	9	35	21	0	0.513	1.000	1.000
531	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN4(1), ARHGAP5(1), CDH5(1), CLDN11(2), CLDN16(1), CLDN18(1), CLDN3(1), CTNNA1(5), CTNNA2(1), CTNNA3(1), CTNNB1(2), EZR(1), GNAI1(1), GNAI2(2), ICAM1(1), ITGA4(1), ITGAL(1), ITGAM(3), ITGB1(1), ITGB2(1), ITK(1), JAM3(1), MAPK14(1), MLLT4(4), MSN(1), NCF2(1), NCF4(1), NOX1(1), NOX3(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLCG2(1), PRKCA(1), PRKCG(2), PTK2(1), PTK2B(1), PXN(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), ROCK1(2), ROCK2(1), SIPA1(1), THY1(1), VAV1(3), VAV3(1), VCAM1(1), VCL(1)	52852549	80	67	78	27	7	11	10	35	17	0	0.835	1.000	1.000
532	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN4(1), DES(1), DMD(5), MYBPC1(2), MYBPC3(1), MYH3(2), MYH6(3), MYH7(6), MYH8(3), MYL4(1), MYOM1(1), NEB(5), TCAP(1), TMOD1(1), TNNT1(1), TPM4(1), TTN(37), VIM(1)	57074839	74	66	73	25	4	9	13	33	15	0	0.842	1.000	1.000
533	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AGL(3), AMY1A(2), AMY1B(2), AMY1C(2), AMY2B(1), ASCC3(2), ATP13A2(3), DDX18(1), DDX23(1), DDX4(2), DDX41(2), DDX47(2), DDX50(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENPP1(2), ENPP3(1), ENTPD7(3), EP400(5), ERCC3(2), GAA(2), GANC(1), GBE1(1), GCK(1), GYS2(1), HK1(2), IFIH1(1), MGAM(3), MOV10L1(2), NUDT5(1), PGM1(1), PYGB(1), PYGM(1), RAD54B(1), SETX(4), SI(2), SKIV2L2(1), SMARCA2(1), SMARCA5(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1)	55864054	87	63	86	21	5	9	14	38	21	0	0.434	1.000	1.000
534	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(1), ANAPC10(1), ANAPC5(3), ANAPC7(1), ATM(5), ATR(2), BUB1B(1), CCNA2(1), CCNB2(1), CCND3(1), CCNE2(1), CDC14A(1), CDC16(1), CDC20(2), CDC23(1), CDC25A(1), CDC25C(1), CDC27(2), CDC6(2), CDK4(1), CDKN1C(1), CDKN2A(1), CHEK1(1), CHEK2(1), CREBBP(8), CUL1(2), DBF4(2), E2F2(1), E2F3(1), EP300(5), ESPL1(2), FZR1(1), GADD45B(2), MAD1L1(1), MCM2(1), MCM3(2), MCM5(1), MCM6(2), PKMYT1(1), PLK1(1), SFN(1), SKP2(1), SMAD2(1), SMAD4(3), SMC1A(1), SMC1B(2)	57359616	76	63	76	27	3	12	15	30	16	0	0.775	1.000	1.000
535	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), AKAP1(1), AKAP10(1), AKAP11(1), AKAP12(3), AKAP3(2), AKAP4(1), AKAP6(2), AKAP9(1), CHMP1B(1), GNA13(2), GNA14(1), GNAI2(2), GNAZ(2), GNB1(1), GNB5(1), GNG10(1), GNG12(1), GNG13(1), ITPR1(6), KCNJ3(1), NRAS(2), PALM2(1), PDE1B(1), PDE1C(2), PDE4A(1), PDE7B(1), PDE8B(1), PLCB3(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCI(3), USP5(2)	48981355	73	62	73	27	3	12	8	30	20	0	0.878	1.000	1.000
536	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(3), CABIN1(3), CAMK2B(2), CREBBP(8), CSNK2A1(2), EP300(5), FCER1A(1), FKBP1B(1), GATA3(1), ICOS(1), IFNG(2), IL2(1), ITK(1), JUNB(1), KPNA5(2), MAP2K7(2), MAPK14(1), NFAT5(2), NFATC2(1), NFATC3(3), NFKB2(2), NUP214(5), P2RX7(1), PAK1(2), PPIA(1), PPP3CB(1), PTPRC(1), RELA(2), SFN(1), SP3(1), TNF(1), TRPV6(1), VAV1(3), VAV3(1), XPO5(2)	38608381	68	59	68	20	6	4	14	23	21	0	0.728	1.000	1.000
537	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(1), CITED2(2), CPT1B(1), CREBBP(8), DUT(1), EHHADH(1), EP300(5), HSD17B4(1), HSPA1A(1), INS(1), LPL(4), MAPK1(1), MRPL11(1), NCOA1(3), NCOR1(7), NCOR2(1), NFKBIA(1), NR2F1(2), NRIP1(1), PIK3CA(6), PIK3R1(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PTGS2(1), RELA(2), RXRA(2), STAT5A(2), STAT5B(1), TNF(1)	27113395	65	58	63	23	4	14	8	19	20	0	0.873	1.000	1.000
538	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(4), CTCFL(5), DOT1L(5), EHMT1(1), EHMT2(3), EZH1(3), FBXO11(3), HCFC1(2), JMJD6(1), NSD1(4), OGT(2), PAXIP1(3), PPP1CC(1), PRDM2(6), PRDM6(1), PRDM7(1), PRMT1(1), PRMT5(3), PRMT6(1), PRMT7(2), SATB1(1), SETD1A(4), SETDB1(4), SETDB2(1), SETMAR(1), SUV39H1(1), SUV39H2(1), SUZ12(1), WHSC1(1)	48897867	67	57	67	17	5	7	13	23	18	1	0.334	1.000	1.000
539	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA2A(2), ADORA3(1), ADRA2A(1), AGTR2(1), C3AR1(3), CCKAR(1), CCKBR(2), CCR10(1), CCR2(1), CCR3(1), CCR5(1), CCR7(1), CCR9(2), CHRM1(2), CHRM2(1), CHRM3(1), DRD2(1), DRD4(1), DRD5(1), F2R(1), F2RL2(1), GPR173(1), GPR174(2), GPR3(1), GPR37(4), GPR37L1(1), GPR50(1), GPR83(1), GPR85(1), GPR87(2), GRPR(1), HCRTR1(1), HCRTR2(4), HTR1A(1), HTR1B(1), HTR2B(2), LHCGR(1), MAS1(1), NPY1R(1), NPY2R(2), OPRM1(1), OR11A1(1), OR5V1(1), OR8B8(1), P2RY1(2), P2RY2(1), PTGDR(1), PTGFR(2), SSTR1(2)	50750072	68	57	68	24	5	8	11	32	12	0	0.730	1.000	1.000
540	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AKT2(1), AKT3(1), APAF1(2), ATM(5), BAX(1), BID(1), BIRC2(1), BIRC3(2), CAPN1(1), CAPN2(1), CASP10(1), CASP6(1), CASP9(1), CFLAR(2), CSF2RB(3), FASLG(2), IKBKB(1), IL1R1(1), NFKB2(2), NFKBIA(1), NTRK1(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), RELA(2), RIPK1(1), TNF(1), TNFRSF10D(1), TNFSF10(3)	35226280	62	53	60	19	4	9	12	23	14	0	0.598	1.000	1.000
541	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	69	A2M(4), C2(1), C3(2), C3AR1(3), C4BPB(1), C5(1), C6(2), C7(1), C8A(2), C8B(1), C9(1), CD46(1), CFH(1), CPB2(1), CR1(3), CR2(1), F10(1), F12(6), F13A1(2), F2(2), F2R(1), F5(3), F8(1), F9(1), KNG1(3), MASP1(2), MASP2(1), MBL2(1), PROS1(1), SERPINA1(1), SERPIND1(1), VWF(2)	44405967	55	50	55	18	4	8	5	27	11	0	0.830	1.000	1.000
542	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF11(1), CFL2(1), INPPL1(2), ITPR1(6), ITPR2(5), ITPR3(3), LIMK1(1), MYLK(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PIK3CA(6), PIK3CD(1), PIK3CG(1), PIK3R1(2), PPP1R13B(2), RACGAP1(1), ROCK1(2), ROCK2(1), WASF1(1), WASL(2)	29167183	51	50	49	16	5	11	5	19	11	0	0.589	1.000	1.000
543	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(1), BRAF(4), CEBPA(1), CREB1(1), DAXX(1), ELK1(1), GRB2(1), IKBKB(1), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K3(1), MAP3K4(3), MAP3K6(3), MAP3K7(1), MAP3K8(1), MAP4K1(1), MAP4K2(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK6(2), MAPKAPK2(1), MEF2C(1), MKNK2(1), NFKBIA(1), PAK1(2), RAF1(3), RELA(2), RIPK1(1), RPS6KA3(1), RPS6KA4(1), RPS6KA5(1), RPS6KB2(1), STAT1(2), TGFBR1(1)	40936972	58	49	57	21	2	5	8	23	20	0	0.954	1.000	1.000
544	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	ABL1(1), ATM(5), BUB1B(1), CCNA2(1), CCNB2(1), CCND3(1), CCNE2(1), CDAN1(3), CDC14A(1), CDC20(2), CDC25A(1), CDC25C(1), CDC6(2), CDH1(2), CDK4(1), CDKN2A(1), CHEK1(1), CHEK2(1), E2F2(1), E2F3(1), E2F5(1), EP300(5), ESPL1(2), HDAC5(3), HDAC6(2), HDAC8(1), MAD1L1(1), MCM2(1), MCM3(2), MCM5(1), MCM6(2), MPEG1(1), PLK1(1), PTPRA(1), SKP2(1), SMAD4(3)	46182279	57	46	57	20	4	9	11	17	16	0	0.692	1.000	1.000
545	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT2(1), AKT3(1), CASP9(1), KDR(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPKAPK2(1), NFAT5(2), NFATC2(1), NFATC3(3), NOS3(1), NRAS(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PPP3CB(1), PRKCA(1), PRKCG(2), PTGS2(1), PTK2(1), PXN(1), RAC2(1), RAF1(3), SHC2(1), SPHK1(1), SPHK2(1)	30508643	53	46	51	16	5	8	7	17	16	0	0.676	1.000	1.000
546	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(5), CACNA1B(4), GNB1(1), GNG13(1), GRM4(2), ITPR3(3), KCNB1(2), PLCB2(3), PRKACG(1), PRKX(1), SCNN1A(2), SCNN1B(3), TAS1R1(1), TAS1R2(2), TAS1R3(3), TAS2R13(1), TAS2R39(1), TAS2R41(1), TAS2R43(1), TAS2R50(2), TRPM5(1)	24304045	47	44	46	17	9	8	4	14	12	0	0.669	1.000	1.000
547	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(1), AKT3(1), BRAF(4), CAB39(1), EIF4B(1), FIGF(1), HIF1A(2), INS(1), MAPK1(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PRKAA1(1), RHEB(1), RICTOR(1), RPS6KA3(1), RPS6KB2(1), STK11(2), TSC1(2), TSC2(6), ULK1(1), ULK2(1), ULK3(1)	22740312	48	43	45	15	7	7	7	15	11	1	0.584	1.000	1.000
548	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(1), ALPPL2(1), ASCC3(2), ATP13A2(3), DDX18(1), DDX23(1), DDX4(2), DDX41(2), DDX47(2), DDX50(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENTPD7(3), EP400(5), ERCC3(2), FPGS(1), GGH(1), IFIH1(1), MOV10L1(2), NUDT5(1), RAD54B(1), SETX(4), SKIV2L2(1), SMARCA2(1), SMARCA5(1)	26693809	46	42	45	14	2	9	7	20	8	0	0.554	1.000	1.000
549	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	APAF1(2), ATM(5), ATR(2), BAI1(1), BAX(1), BID(1), CASP9(1), CCNB2(1), CCND3(1), CCNE2(1), CCNG2(1), CDK4(1), CDKN2A(1), CHEK1(1), CHEK2(1), GADD45B(2), GTSE1(2), PPM1D(2), RCHY1(2), RFWD2(2), SESN1(2), SFN(1), THBS1(5), TSC2(6), ZMAT3(1)	26933360	46	42	46	14	3	7	9	13	14	0	0.574	1.000	1.000
550	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(3), APH1A(1), CREBBP(8), CTBP1(1), DTX3L(1), DVL3(1), EP300(5), JAG1(4), MAML1(3), MAML2(3), MAML3(2), NCOR2(1), NCSTN(1), NOTCH1(2), NOTCH2(1), NOTCH3(4), NOTCH4(1), NUMB(1), NUMBL(1), PSEN1(1), SNW1(1)	30012141	46	42	46	26	0	5	5	17	19	0	0.999	1.000	1.000
551	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(1), BMP7(1), BMP8A(1), BTRC(2), CSNK1E(3), GLI1(4), GLI3(2), IHH(1), LRP2(11), PRKACG(1), PRKX(1), PTCH1(1), PTCH2(1), SHH(1), SMO(1), SUFU(2), WNT10A(2), WNT2(1), WNT2B(1), WNT7A(1), WNT7B(1), WNT8B(1), WNT9B(2), ZIC2(2)	25858401	45	41	45	14	5	10	5	15	10	0	0.562	1.000	1.000
552	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(5), CCND3(1), CCNE2(1), CCNG2(1), CDC25A(1), CDK4(1), CDKN1C(1), CDKN2A(1), CREB3L1(2), CREB3L3(1), E2F2(1), E2F3(1), E2F5(1), GBA2(3), MCM2(1), MCM3(2), MCM5(1), MCM6(2), MYT1(6), NACA(1), POLE(1), RPA2(1), TNXB(5)	32370315	41	40	41	13	6	10	7	11	7	0	0.295	1.000	1.000
553	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1E2(2), ATP6V1H(1), EGFR(1), IKBKB(1), JAM3(1), LYN(3), MAPK10(1), MAPK14(1), NFKB2(2), NFKBIA(1), NOD1(2), PAK1(2), PLCG2(1), PTPRZ1(5), RELA(2), TCIRG1(1), TJP1(2)	28836951	43	40	43	17	1	1	8	23	10	0	0.933	1.000	1.000
554	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ASAH1(1), BRAF(4), CREB1(1), CREBBP(8), DAG1(3), EGR1(1), EGR4(1), ELK1(1), FRS2(1), MAP1B(3), MAP2K7(2), MAPK1(1), MAPK10(1), MAPK8IP1(1), NTRK1(1), PIK3C2G(3), PIK3CA(6), PIK3CD(1), PIK3R1(2), RPS6KA3(1), TERF2IP(1)	21958250	44	39	41	15	4	10	7	14	9	0	0.530	1.000	1.000
555	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	INPP4A(1), INPP4B(1), INPP5B(2), INPP5E(1), INPPL1(2), ITPK1(2), ITPKA(1), ITPKB(1), MINPP1(1), OCRL(1), PI4KA(2), PIK3C3(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIP4K2A(1), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1), PLCZ1(2), SYNJ2(1)	31198720	41	38	39	17	3	5	6	15	12	0	0.913	1.000	1.000
556	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT2(1), AKT3(1), BRD4(2), CDKN2A(1), F2RL2(1), FLOT1(1), GRB2(1), IGFBP1(1), INPPL1(2), IRS1(2), IRS2(3), LNPEP(2), MAPK1(1), PARD3(2), PIK3CA(6), PIK3CD(1), PIK3R1(2), PTPN1(1), RAF1(3), RPS6KA3(1), SFN(1), SLC2A4(2), SORBS1(1), SOS1(2), SOS2(1)	24597943	42	38	40	16	6	8	4	16	8	0	0.712	1.000	1.000
557	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(2), BID(1), BIRC2(1), BIRC3(2), CASP6(1), CASP9(1), CFLAR(2), DAXX(1), GSN(1), LMNA(2), LMNB1(1), LMNB2(1), MAP2K7(2), MAP3K1(3), NFKBIA(1), NUMA1(2), PRKCD(2), PSEN1(1), PTK2(1), RASA1(2), RELA(2), RIPK1(1), SPTAN1(3), TNF(1), TNFRSF1B(2)	29197838	39	36	39	18	0	3	7	14	15	0	0.988	1.000	1.000
558	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(2), BAX(1), BCL2L11(1), BID(1), BIRC2(1), BIRC3(2), BIRC5(1), CASP10(1), CASP4(1), CASP6(1), CASP9(1), FASLG(2), IKBKB(1), IRF2(1), IRF4(1), IRF5(1), IRF6(1), IRF7(1), MAP3K1(3), MAPK10(1), NFKBIA(1), PLEKHG5(1), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(2), TNFRSF21(1), TNFSF10(3)	24181825	37	34	37	15	2	7	5	14	9	0	0.893	1.000	1.000
559	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(3), CREBBP(8), EP300(5), ERCC3(2), GRIP1(4), GTF2A1(2), GTF2F1(1), HDAC5(3), HDAC6(2), MEF2C(1), NCOR2(1), NRIP1(1), POLR2A(1), TBP(1)	19887436	35	34	35	22	3	3	6	13	10	0	0.996	1.000	1.000
560	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	ALG2(1), BAX(1), BFAR(2), CAD(4), CASP10(1), CD7(2), DAXX(1), DEDD(1), EGFR(1), EPHB2(1), MAP2K7(2), MAP3K1(3), MAPK1(1), MAPK10(1), MAPK8IP1(1), NFAT5(2), NFKB2(2), NFKBIA(1), NFKBIL1(1), PFN1(1), PTPN13(2), RALBP1(2), RIPK1(1), ROCK1(2), SMPD1(4), TPX2(1)	29588261	42	33	41	18	6	5	5	18	8	0	0.948	1.000	1.000
561	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(3), ASAH1(1), DAG1(3), EPHB2(1), GNAI1(1), ITPR1(6), ITPR2(5), ITPR3(3), KCNJ3(1), MAPK1(1), RYR1(7)	19367225	32	32	32	10	4	3	5	14	6	0	0.669	1.000	1.000
562	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(1), AGPAT2(1), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), ESCO1(2), ETNK2(2), GPAM(2), GPD1(2), GPD1L(1), GPD2(1), LCAT(2), PCYT1A(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLD1(1), PNPLA3(1), PPAP2B(1), PTDSS2(1)	28001652	34	31	34	10	1	7	5	11	10	0	0.471	1.000	1.000
563	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	AKT2(1), AKT3(1), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), NFKB2(2), NFKBIA(1), NFKBIL1(1), PHKA2(2), PIK3CB(2), PLD1(1), PLD3(1), VN1R1(1)	19365337	32	31	32	10	2	4	8	10	8	0	0.546	1.000	1.000
564	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CEBPA(1), DAXX(1), EGF(1), EGFR(1), ETS1(2), HOXA7(2), IKBKB(1), MAP2K3(1), MAP2K7(2), MAP3K1(3), MAPK1(1), MAPK14(1), NFKBIA(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), RAF1(3), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(2)	20407881	34	30	34	15	2	1	3	15	13	0	0.992	1.000	1.000
565	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(2), EEF1A2(1), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(1), EIF1AX(1), EIF2AK1(3), EIF2AK3(1), EIF2B5(1), EIF2S3(1), EIF4A1(1), EIF4A2(3), EIF4G1(3), EIF4G3(4), EIF5(1), GSPT2(1), PABPC1(1), PABPC3(1), PAIP1(1), SLC35A4(1)	18578059	34	30	34	12	3	5	2	13	10	1	0.895	1.000	1.000
566	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(1), ADH6(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDOB(2), DLAT(1), DLD(2), ENO1(1), ENO2(1), GAPDH(1), GAPDHS(1), GCK(1), HK1(2), PFKL(1), PFKP(1), PGAM2(1), PGAM4(1), PGK2(1), PGM1(1)	24437858	30	29	30	10	4	3	4	8	10	1	0.831	1.000	1.000
567	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	ELK1(1), GRB2(1), MAP3K1(3), NFATC2(1), NFATC3(3), NFKBIA(1), PIK3CA(6), PIK3R1(2), PPP3CB(1), PRKCA(1), RAF1(3), RASA1(2), RELA(2), SOS1(2), VAV1(3), ZAP70(1)	20103595	33	29	31	12	2	7	2	11	11	0	0.895	1.000	1.000
568	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	COX10(3), COX15(2), CP(3), EPRS(1), FTH1(1), FTMT(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1)	17235292	30	28	30	14	1	1	8	15	5	0	0.972	1.000	1.000
569	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(5), CDK4(1), DMC1(1), EGR1(1), ESR2(2), GJA4(1), LHCGR(1), MLH1(3), NCOR1(7), NRIP1(1), PRLR(1), SMPD1(4), ZP2(2)	14650348	30	28	29	10	2	4	2	18	4	0	0.772	1.000	1.000
570	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), LIMK1(1), MAP3K1(3), MYLK(1), NCF2(1), PAK1(2), PDGFRA(1), PIK3CA(6), PIK3R1(2), PLD1(1), PPP1R12B(1), RALBP1(2), TRIO(5), VAV1(3), WASF1(1)	14691042	31	28	29	11	5	7	2	12	5	0	0.731	1.000	1.000
571	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(2), BAX(1), BID(1), BIRC2(1), BIRC3(2), CASP6(1), CASP9(1), FASLG(2), MAP3K1(3), MAPK10(1), MCL1(1), NFKBIA(1), PARP1(3), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(2), TNFSF10(3)	15569297	29	27	29	11	1	3	5	13	7	0	0.917	1.000	1.000
572	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(2), ACACB(1), ACSS1(1), ACSS2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DLAT(1), DLD(2), HAGH(1), ME2(1), PC(5), PCK1(5), PCK2(1)	19672542	28	27	28	10	2	1	6	8	10	1	0.902	1.000	1.000
573	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(8), EP300(5), LPL(4), NCOA1(3), NCOA2(4), PPARG(1), RXRA(2)	7685324	27	27	27	11	2	7	3	4	11	0	0.909	1.000	1.000
574	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(3), CDH1(2), CTNNB1(2), EZR(1), ITGB1(1), NCL(2), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(3), TUBA3D(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB1(1), WASL(2)	22224358	26	26	26	14	0	2	6	11	7	0	0.989	1.000	1.000
575	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(3), CDH1(2), CTNNB1(2), EZR(1), ITGB1(1), NCL(2), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(3), TUBA3D(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB1(1), WASL(2)	22224358	26	26	26	14	0	2	6	11	7	0	0.989	1.000	1.000
576	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), BTG1(1), CBX3(1), CRY1(1), EIF4G2(1), HERPUD1(1), HSPA8(2), MYF6(2), NCKAP1(1), NCOA4(1), NR1D2(1), PER1(4), PER2(2), SF3A3(1), SUMO3(1), TOB1(2), ZFR(2)	15408395	25	25	25	11	1	2	4	14	4	0	0.950	1.000	1.000
577	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), DLAT(1), DLD(2), ENO1(1), ENO2(1), GAPDH(1), GAPDHS(1), GCK(1), GOT2(1), HK1(2), PC(5), PCK1(5), PFKL(1), PFKP(1), PGAM2(1), PGK2(1)	17758926	27	25	27	11	1	4	4	6	11	1	0.958	1.000	1.000
578	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), BCR(2), CAPN1(1), GRB2(1), ITGA1(3), ITGB1(1), MAP2K2(1), MAPK1(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(3), ROCK1(2), SOS1(2), TLN1(6), VCL(1)	19861543	28	25	28	10	2	2	1	13	10	0	0.858	1.000	1.000
579	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	ERCC3(2), GTF2A2(1), GTF2B(2), GTF2H4(1), POLR1A(5), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2F(1), POLR2K(1), POLR3E(1), POLR3H(1), TAF12(1), TAF6(1), TAF7(1), TAF9(1), TBP(1)	15046131	26	25	26	15	1	3	3	10	9	0	0.979	1.000	1.000
580	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	ATF2(1), DLD(2), GCK(1), IL1R1(1), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K3(1), MAP3K4(3), MAP3K7(1), MAPK10(1), NFATC3(3), PAPPA(4), ZAK(1)	20769565	28	25	28	14	0	1	3	15	8	1	0.994	1.000	1.000
581	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BID(1), BIRC2(1), BIRC3(2), CASP10(1), CASP6(1), CASP9(1), CFLAR(2), GAS2(1), LMNA(2), NFKBIA(1), RELA(2), RIPK1(1), SPTAN1(3), TNFSF10(3)	14096545	24	24	24	10	0	2	6	9	7	0	0.913	1.000	1.000
582	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(5), ATR(2), BRCA1(3), CDC25A(1), CDC25C(1), CHEK1(1), CHEK2(1), EP300(5), MYT1(6)	17421818	25	24	25	10	1	8	2	6	8	0	0.870	1.000	1.000
583	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(3), AXIN1(3), CREBBP(8), CTNNB1(2), EP300(5), FZD1(1), LDB1(1), LEF1(1), TRRAP(1)	13923838	25	24	25	10	1	3	4	11	6	0	0.888	1.000	1.000
584	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT2(1), AKT3(1), ARHGEF11(1), GNA13(2), LPA(3), MAP3K1(3), NFKB2(2), NFKBIA(1), NFKBIL1(1), PHKA2(2), PI3(1), PIK3CB(2), PLD1(1), PLD3(1), PTK2(1), RDX(1), ROCK1(2), ROCK2(1)	21448809	27	23	27	17	2	1	4	12	8	0	0.994	1.000	1.000
585	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BAX(1), CASP10(1), CASP4(1), CASP6(1), CASP9(1), CD40(1), DAXX(1), FASLG(2), IKBKE(1), MCL1(1), NFKBIA(1), NGFR(1), NR3C1(2), NTRK1(1), PTPN13(2), RIPK1(1), TNF(1), TNFRSF1B(2)	18286505	24	22	24	10	1	4	4	7	8	0	0.918	1.000	1.000
586	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), ATF2(1), EGFR(1), ELK1(1), GRB2(1), MAP2K2(1), MAP3K1(3), MAPK1(1), MEF2C(1), PAK1(2), PRKCA(1), PTK2(1), PTK2B(1), RAF1(3), SOS1(2)	14235107	23	22	23	12	2	2	2	10	7	0	0.957	1.000	1.000
587	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(2), GRB2(1), JAK2(1), MAP3K1(3), PIK3CA(6), PIK3R1(2), RAF1(3), SOS1(2), STAT1(2), STAT5A(2), STAT5B(1)	11736578	25	22	23	10	1	5	0	11	8	0	0.935	1.000	1.000
588	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(1), ACTR2(1), ACTR3(1), CFL2(1), FLNC(1), LIMK1(1), MYLK(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PFN1(1), ROCK1(2), ROCK2(1), WASF1(1), WASL(2)	20282546	22	22	22	10	3	5	3	8	3	0	0.816	1.000	1.000
589	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	GNAI1(1), GNB1(1), MAPK1(1), PIK3C2G(3), PIK3CA(6), PIK3R1(2), PRKCA(1), PTK2(1), PTK2B(1), PXN(1), RAF1(3), RELA(2)	11709092	23	21	21	11	2	6	0	8	7	0	0.957	1.000	1.000
590	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(1), ADCY3(2), ADCY9(3), ARF3(1), ARF5(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V1A(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1E2(2), ATP6V1H(1), PDIA4(1), PLCG2(1), PRKCA(1)	15701413	21	21	21	10	1	2	3	8	7	0	0.954	1.000	1.000
591	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(1), CAPN2(1), EGF(1), EGFR(1), ITGA1(3), ITGB1(1), MAPK1(1), MYLK(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PTK2(1), PXN(1), TLN1(6)	13899188	23	20	23	10	2	3	3	8	7	0	0.849	1.000	1.000
592	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2A1(2), GTF2B(2), GTF2F1(1), NCOA1(3), NCOA2(4), NCOA3(2), NCOR2(1), POLR2A(1), RXRA(2), TBP(1)	10551839	21	20	21	14	2	3	2	7	7	0	0.983	1.000	1.000
593	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(1), CASP6(1), CFLAR(2), DAXX(1), LMNA(2), LMNB1(1), LMNB2(1), MAP3K1(3), MAP3K7(1), PAK1(2), PTPN13(2), SPTAN1(3)	17404519	20	19	20	14	0	0	6	6	8	0	0.999	1.000	1.000
594	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(3), EPRS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2)	11532644	20	19	20	10	0	1	7	7	5	0	0.968	1.000	1.000
595	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), CAPN1(1), ITGA1(3), ITGB1(1), ITGB3(3), PTK2(1), PXN(1), SPTAN1(3), TLN1(6)	12038924	20	19	20	10	1	2	2	7	8	0	0.960	1.000	1.000
596	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	21	F10(1), F12(6), F2(2), F5(3), F8(1), F9(1), LPA(3), VWF(2)	15295394	19	18	19	11	3	1	3	5	7	0	0.991	1.000	1.000
597	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	LMNA(2), LMNB1(1), LMNB2(1), MADD(4), MAP3K1(3), MAP3K7(1), PAK1(2), RIPK1(1), SPTAN1(3), TNF(1)	16469039	19	18	19	12	0	0	5	8	6	0	0.997	1.000	1.000
598	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CREB1(1), DAXX(1), ELK1(1), GRB2(1), HSPB2(1), MAP3K1(3), MAP3K7(1), MAPK14(1), MAPKAPK2(1), MEF2C(1), PLA2G4A(1), RIPK1(1), RPS6KA5(1), STAT1(2), TGFBR1(1)	15580736	19	16	19	13	0	3	3	8	5	0	0.997	1.000	1.000
599	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(3), DDX20(4), ETS1(2), HDAC5(3), NCOR2(1), SIN3A(2), SIN3B(2)	11243536	17	15	17	10	2	3	1	9	2	0	0.909	1.000	1.000
600	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), HDAC5(3), MEF2C(1), PPP3CB(1), SLC2A4(2)	8731904	14	14	14	7	4	1	2	7	0	0	0.789	1.000	1.000
601	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD2(1), GRM1(1), PLCB1(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2)	6735888	7	7	7	11	1	1	2	1	2	0	0.998	1.000	1.000
602	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA3(1), GPHN(4)	5315406	5	5	5	4	2	0	0	3	0	0	0.947	1.000	1.000
603	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	GPR18(2), GPR34(1), GPR39(1), GPR65(1)	4123324	5	5	5	4	1	1	0	3	0	0	0.969	1.000	1.000
604	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), MEF2C(1)	3418490	4	4	4	5	1	0	1	2	0	0	0.970	1.000	1.000
605	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA3(1), PRKCE(2)	2999407	3	3	3	4	1	0	0	2	0	0	0.986	1.000	1.000
606	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH6(2)	2340952	2	2	2	2	0	0	0	2	0	0	0.968	1.000	1.000
607	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNB1(1), PRKAR1A(1)	2813075	2	2	2	2	0	0	1	1	0	0	0.981	1.000	1.000
608	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1)	1756852	1	1	1	4	0	0	0	1	0	0	0.999	1.000	1.000
609	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	SP3(1)	2658441	1	1	1	2	0	0	1	0	0	0	0.962	1.000	1.000
610	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4		991302	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		303179	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		935102	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2		839458	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8		3162488	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
615	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		487291	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4		1347964	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
