rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(3)	1555735	7	7	7	0	3	2	0	1	1	0	0.127	0.00310	1.000
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(4), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CFL1(1), E2F1(1), E2F2(1), MDM2(3), PRB1(1)	5804677	22	17	22	3	5	1	4	4	8	0	0.0867	0.00340	1.000
3	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCND1(4), CCNE1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(3), CDKN2A(4), E2F1(1), E2F2(1), PRB1(1)	6835457	20	16	20	0	4	1	5	2	8	0	0.00260	0.00940	1.000
4	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(3), HGD(5)	1707352	10	6	10	2	4	0	1	2	3	0	0.309	0.0303	1.000
5	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPP(4), ENPP1(4), ENPP3(2), FLAD1(2), TYR(4)	7436313	17	14	17	1	6	2	2	5	2	0	0.0379	0.0395	1.000
6	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCNB1(2), CCND1(4), CCNE1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), E2F1(1), RB1(7), RBL1(4)	12315604	38	25	38	4	7	4	9	5	13	0	0.0113	0.0427	1.000
7	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(2), CDK2(1), CUL1(1), E2F1(1), FBXW7(4), RB1(7)	6347312	17	13	17	1	4	2	3	2	6	0	0.0627	0.0459	1.000
8	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CCNE1(1), CDC34(2), CDK2(1), CUL1(1), E2F1(1), RB1(7), SKP2(2)	6559026	17	13	17	1	2	2	5	1	7	0	0.0730	0.0501	1.000
9	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	10	CBL(1), CSF1R(4), EGF(7), MET(10), PRKCA(5), SH3GLB1(3), SH3KBP1(5)	11129068	35	19	35	7	13	3	4	9	5	1	0.0659	0.0553	1.000
10	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(5), ALPPL2(2), DHFR(1), FPGS(2), GGH(1), SPR(1)	4986272	13	12	13	2	5	2	3	1	2	0	0.161	0.0699	1.000
11	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ5(3), COQ6(2), NDUFB11(1)	3077711	9	7	9	0	1	4	0	2	2	0	0.0791	0.0779	1.000
12	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACPP(4), ENPP1(4), ENPP3(2), FLAD1(2), MTMR1(4), MTMR2(3), MTMR6(1), TYR(4)	11528162	25	19	25	2	6	4	4	7	4	0	0.0235	0.0885	1.000
13	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDK2(1), CDKN1B(3), CUL1(1), E2F1(1), RB1(7), RBX1(1), SKP2(2), UBE2M(1)	6571866	18	14	18	2	1	3	5	1	8	0	0.149	0.0927	1.000
14	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), ENPP1(4), ENPP3(2), NADSYN1(4), NMNAT1(1), NNMT(1), NNT(5), NT5C(3), NT5E(1), NT5M(1)	11163287	27	18	27	2	4	9	4	7	3	0	0.00451	0.0940	1.000
15	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(12)	6470917	13	11	13	2	2	2	3	4	2	0	0.169	0.108	1.000
16	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), RB1(7), SP3(4)	5114449	12	9	12	1	1	0	3	1	7	0	0.304	0.118	1.000
17	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(3), ATM(8), BAX(1), CCND1(4), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), E2F1(1), MDM2(3), RB1(7), TIMP3(1)	13286988	32	20	32	5	5	3	7	9	8	0	0.119	0.145	1.000
18	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), CYP2A7(1), NAT1(1), NAT2(3), XDH(8)	6114871	16	11	16	1	4	3	1	6	2	0	0.0312	0.157	1.000
19	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(5), IL12B(2), IL18(3)	2286577	10	6	10	2	2	1	1	6	0	0	0.430	0.157	1.000
20	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(1), CAT(3), GH1(1), GHR(4), IGF1(1), IGF1R(7), SHC1(1), SOD2(1)	7315753	19	13	19	1	4	3	4	5	3	0	0.00940	0.161	1.000
21	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(6), AMY2B(3), ENPP1(4), ENPP3(2), G6PC(7), GAA(5), GANAB(4), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(3), HK3(3), MGAM(8), PGM3(1), PYGB(1), PYGL(5), PYGM(1), SI(10), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(5), UXS1(2)	43653770	105	64	104	15	36	18	14	24	13	0	2.28e-05	0.203	1.000
22	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(4), DPYS(4), ENPP1(4), ENPP3(2), PANK2(1), PANK4(4)	10666449	22	17	21	4	5	5	0	7	5	0	0.250	0.209	1.000
23	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	7746586	20	11	20	4	4	3	4	6	3	0	0.218	0.217	1.000
24	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(2), DPYD(4), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(5), PANK2(1), PANK4(4), VNN1(2)	13235696	29	22	28	4	7	6	1	9	6	0	0.0719	0.229	1.000
25	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(4), DBH(3), DDC(3), GAD1(2), GAD2(1), HDC(2), MAOA(2), PAH(2), TH(3), TPH1(4)	11020178	29	18	29	6	12	8	0	7	2	0	0.0390	0.229	1.000
26	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(2), CCR3(1), CD4(1), HLA-DRA(3), HLA-DRB1(1), IL1B(2), IL5(1), IL5RA(2), IL6(1)	4104039	14	9	14	2	2	4	0	7	1	0	0.115	0.229	1.000
27	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5)	1624242	5	4	5	0	2	1	0	2	0	0	0.207	0.245	1.000
28	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(1), IGF1R(7), POLR2A(7), PPP2CA(4), PRKCA(5), RB1(7), TEP1(8), TERF1(1), TERT(3), TNKS(1), XRCC5(3)	18961508	47	29	47	8	17	2	9	11	7	1	0.0181	0.260	1.000
29	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(1), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(7), ZAP70(5)	6947285	20	13	20	4	5	5	1	8	1	0	0.195	0.263	1.000
30	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(7), ERBB3(4), NRG1(3)	5885404	14	10	14	2	7	2	0	1	4	0	0.196	0.267	1.000
31	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(2), GPI(2), HK1(4), PFKL(5), PGK1(2), PKLR(2), TPI1(1)	7108176	19	12	19	0	8	6	0	1	4	0	0.000189	0.267	1.000
32	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(1), GALNT2(2), GALNT3(1), GALNT4(3), GALNT6(3), GALNT7(1), GALNT8(1), GALNT9(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), WBSCR17(5)	11078056	29	18	29	5	10	4	4	8	3	0	0.0762	0.281	1.000
33	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(5), COL4A4(4), COL4A5(9), COL4A6(6), F10(1), F12(1), F2(3), F2R(2), F5(7), F8(20), F9(3), FGA(6), FGB(1), FGG(1), KLKB1(5), PROS1(1), SERPINC1(1), SERPING1(3)	34041840	81	50	81	16	20	14	14	21	11	1	0.00412	0.282	1.000
34	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	2431617	5	4	5	0	0	0	3	0	2	0	0.337	0.293	1.000
35	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), GGPS1(1), IDI1(2), SQLE(1)	3261825	6	5	6	0	0	0	4	0	2	0	0.227	0.295	1.000
36	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(3), GAD1(2), HDC(2), TH(3), TPH1(4)	4613301	14	9	14	2	7	3	0	3	1	0	0.0601	0.308	1.000
37	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(4), NMNAT1(1), NMNAT3(1), NNMT(1), NNT(5), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1)	16500726	36	22	36	6	7	11	5	8	5	0	0.0262	0.315	1.000
38	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(1)	1822679	6	4	6	1	1	1	0	3	1	0	0.359	0.316	1.000
39	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	FUT8(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3)	6036845	14	13	14	3	5	2	3	2	2	0	0.264	0.328	1.000
40	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(2), TAT(1), TYR(4)	3613786	10	7	10	3	5	0	1	4	0	0	0.603	0.331	1.000
41	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(2), CCL5(1), CCR3(1), HLA-DRA(3), HLA-DRB1(1), IL3(1), IL5(1)	2335625	10	6	10	3	2	2	0	4	2	0	0.491	0.331	1.000
42	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4)	6064241	22	16	22	6	5	5	2	7	3	0	0.299	0.343	1.000
43	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(5), LPO(5), MPO(2), PRDX1(1), TPO(6), TYR(4)	7401127	23	13	23	5	9	7	1	5	0	1	0.0660	0.358	1.000
44	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), HTR2C(3), PLCB1(3), TUB(4)	5487240	12	9	12	3	4	2	0	5	1	0	0.371	0.358	1.000
45	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(2), HBEGF(1), IFRD1(3), IL18(3), IL1R1(2), NR4A3(1), WDR1(1)	8243333	17	12	17	2	5	1	2	5	4	0	0.143	0.409	1.000
46	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL10(1), IL12B(2), IL15(2), IL16(8), IL18(3), IL3(1), IL5(1), IL6(1), IL9(1), TNF(1)	7618258	22	15	22	5	3	2	4	9	4	0	0.329	0.409	1.000
47	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(2), EIF4E(2), FBL(2), LDHA(1), LDHB(2), LDHC(1), NCL(2)	6847415	15	9	15	3	3	4	1	4	3	0	0.240	0.422	1.000
48	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(1), GAD1(2), GAD2(1), GGT1(2)	4410044	7	6	7	0	2	1	2	2	0	0	0.0978	0.426	1.000
49	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(2), ARHGDIB(1), CASP1(5), CASP8(2), CYCS(2), GZMB(1), PRF1(3)	9878151	19	13	19	4	5	5	2	7	0	0	0.219	0.428	1.000
50	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	1265612	5	2	5	0	0	3	0	2	0	0	0.195	0.429	1.000
51	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(4), PDHA1(5), PDHA2(4)	5341985	15	10	14	4	2	7	1	3	2	0	0.181	0.432	1.000
52	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(2), CFL1(1), LIMK1(4), MAP3K1(4), MYL2(2), MYLK(5), NCF2(3), PAK1(2), PLD1(7), RAC1(1), RALBP1(2), RPS6KB1(2), TRIO(5), VAV1(5), WASF1(1)	22139671	46	27	46	5	14	4	8	11	9	0	0.00161	0.437	1.000
53	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(4), SP3(4), WT1(1)	4780132	9	7	7	0	4	1	1	2	1	0	0.0521	0.441	1.000
54	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(3), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(5)	13491856	28	20	27	5	7	3	7	10	1	0	0.0660	0.443	1.000
55	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(8), CDC25A(1), CDC25B(1), CDK2(1), CDK4(1), CHEK1(3), MYT1(7), RB1(7), WEE1(1), YWHAH(1)	12876889	31	18	31	6	4	2	5	4	16	0	0.410	0.445	1.000
56	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT5(4), FUT1(1), FUT2(2), ST3GAL3(2), ST3GAL4(3)	5530723	16	10	16	3	7	0	1	5	3	0	0.208	0.455	1.000
57	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2), CFL1(1), CFLAR(1)	2977582	4	4	4	0	0	1	1	1	1	0	0.228	0.468	1.000
58	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(3), GLS(2), GLUD1(5), GOT1(2)	5986993	14	7	14	2	2	1	0	5	6	0	0.331	0.471	1.000
59	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(3), EPRS(3), FECH(1), GUSB(3), HCCS(4), PPOX(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(5), UROD(1), UROS(1)	20995792	44	30	43	8	11	5	12	15	1	0	0.0305	0.483	1.000
60	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(3), HYAL2(2), IDS(2), LCT(10), NAGLU(3), SPAM1(3)	15716131	37	23	37	6	17	2	6	6	6	0	0.0322	0.483	1.000
61	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	1395557	3	3	3	1	2	0	0	1	0	0	0.732	0.493	1.000
62	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5), PDXK(1), PSAT1(2)	3724214	8	6	8	3	3	3	0	2	0	0	0.560	0.500	1.000
63	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(1), ALAS2(1), CPO(2), FECH(1), HBA2(1), HBB(1), UROD(1), UROS(1)	6021833	11	7	11	2	4	2	1	3	1	0	0.215	0.513	1.000
64	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(4), MTMR2(3), MTMR6(1), NFS1(3), THTPA(2)	4915592	13	6	13	2	1	3	2	5	2	0	0.308	0.520	1.000
65	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(1), CCND1(4), CCNE1(1), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN1B(3), E2F1(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(2), PAK1(2), RAC1(1), RAF1(1), RB1(7), RELA(1)	12605547	32	19	32	6	6	2	6	3	14	1	0.137	0.530	1.000
66	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(2), ELK1(3), FOS(1), IGF1(1), IGF1R(7), IRS1(4), MAPK3(1), MAPK8(2), PTPN11(7), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2)	16140365	40	30	38	9	8	9	5	10	7	1	0.0743	0.532	1.000
67	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL4R(2), JAK1(1), JAK2(4), TYK2(7)	8056469	17	10	17	2	5	0	3	5	4	0	0.103	0.533	1.000
68	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL4R(2), JAK1(1), JAK2(4), TYK2(7)	8056469	17	10	17	2	5	0	3	5	4	0	0.103	0.533	1.000
69	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F12(1), F13B(4), F2(3), F5(7), F7(2), F8(20), F9(3), FGA(6), FGB(1), FGG(1), LPA(7), PLAT(1), PLG(4), SERPINB2(2), SERPINE1(2), SERPINF2(1), VWF(7)	27079747	73	42	73	16	18	12	10	21	12	0	0.0207	0.537	1.000
70	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(1), BRAF(6), CREB1(1), MAPK1(2), RAF1(1), SNX13(1), TERF2IP(1)	8552402	14	9	13	1	1	0	4	5	4	0	0.0834	0.554	1.000
71	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(2), GFPT1(4), GNPDA1(2), HEXA(1), HEXB(1), HK1(4), HK2(3), HK3(3), PGM3(1), RENBP(3), UAP1(2)	13000975	28	19	28	4	8	7	4	6	3	0	0.0273	0.566	1.000
72	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(2), FUT5(3), FUT6(2), ST3GAL3(2)	3901442	10	6	10	2	6	1	0	1	2	0	0.303	0.569	1.000
73	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(8), ATR(6), CCNA1(2), CCND1(4), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), DHFR(1), E2F1(1), RB1(7), SKP2(2), TGFB2(2), TGFB3(1)	22545243	51	28	51	8	10	6	9	10	16	0	0.0301	0.569	1.000
74	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), NR1H3(5), RXRA(1)	4175693	7	6	6	2	3	2	2	0	0	0	0.339	0.576	1.000
75	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	9	ACLY(3), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(1)	8949329	18	10	18	1	6	4	2	3	3	0	0.00792	0.593	1.000
76	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(1), EIF2S2(1), EIF4E(2), IGF1(1), IGF1R(7), INPPL1(5), PPP2CA(4), RPS6KB1(2)	11555038	23	13	23	3	5	3	5	7	3	0	0.0444	0.611	1.000
77	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(9), DFFA(2), GZMA(1), GZMB(1), HMGB2(1), PRF1(3), SET(1)	8112658	20	12	20	3	9	1	2	5	3	0	0.117	0.612	1.000
78	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), LCT(10), MPI(2), PYGL(5), PYGM(1), TPI1(1)	10283177	23	14	23	4	6	4	3	4	6	0	0.0500	0.613	1.000
79	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(2), SHMT1(2)	3195549	5	4	5	1	2	1	2	0	0	0	0.351	0.621	1.000
80	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(1), IL10(1)	3051417	7	5	7	3	1	1	1	3	1	0	0.637	0.642	1.000
81	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(3)	2360464	5	3	5	2	1	1	0	2	1	0	0.649	0.648	1.000
82	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(4), FOS(1), FYN(1), THBS1(4)	5676993	10	7	10	3	3	4	2	0	1	0	0.295	0.650	1.000
83	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(2), CMAS(2), GFPT1(4), GFPT2(3), GNPDA1(2), GNPNAT1(2), HEXA(1), HEXB(1), HK1(4), HK2(3), HK3(3), MTMR1(4), MTMR2(3), MTMR6(1), NANS(1), PGM3(1), RENBP(3), UAP1(2)	22000028	42	29	42	7	9	9	7	10	7	0	0.0302	0.654	1.000
84	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(1), AGPAT6(1), AGPS(3), ENPP2(3), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(7), PPAP2A(2), PPAP2C(1)	17753159	40	22	40	8	8	6	8	13	5	0	0.0717	0.654	1.000
85	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(1), CD3D(1), CD86(1), CTLA4(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), ITK(1), LCK(1), PTPN11(7)	6925185	18	15	16	5	2	4	2	8	2	0	0.420	0.655	1.000
86	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(3), EGF(7), HGS(3), TF(2), TFRC(2)	7830351	17	12	17	5	6	3	2	4	2	0	0.390	0.678	1.000
87	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACPP(4), ALPI(1), ALPP(5), ALPPL2(2), CYP3A4(3), CYP3A7(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), PON1(2), PON3(1)	13793896	26	21	25	5	13	1	2	4	6	0	0.0943	0.692	1.000
88	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(1)	2018992	3	2	3	1	1	0	1	1	0	0	0.729	0.696	1.000
89	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	CYCS(2), SDHA(4), SDHC(2), UQCRC1(3)	5070356	11	7	10	2	2	2	4	3	0	0	0.228	0.696	1.000
90	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(5), AGT(2), AGTR2(3), ANPEP(3), CMA1(2), CTSA(1), CTSG(2), ENPEP(6), LNPEP(2), MME(2), NLN(1), REN(2), THOP1(5)	16249989	40	25	39	10	11	6	6	11	6	0	0.157	0.696	1.000
91	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), PTGS1(2), PTGS2(2)	4103759	7	6	7	2	4	0	0	2	1	0	0.690	0.698	1.000
92	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(1), ALDOB(1), TPI1(1)	3004731	7	3	7	0	0	4	0	2	1	0	0.101	0.703	1.000
93	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	7	ACO1(5), ACO2(4), FH(1)	5576639	10	6	10	0	3	2	2	2	1	0	0.0346	0.707	1.000
94	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(2), BAX(1), BIRC2(2), CASP8(2), CYCS(2), DFFA(2), DIABLO(1)	10285959	15	11	15	3	4	4	2	4	1	0	0.191	0.714	1.000
95	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), CSNK2A1(2), ELK1(3), FOS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(4), JAK3(3), MAPK3(1), PTPN11(7), RAF1(1), SHC1(1), SOS1(4), SRF(2), STAT3(2)	18321791	38	25	36	8	6	8	2	14	7	1	0.102	0.726	1.000
96	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(1), PRKCA(5)	3779974	8	5	8	3	3	0	1	3	0	1	0.602	0.729	1.000
97	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	873576	1	1	1	1	0	1	0	0	0	0	0.898	0.731	1.000
98	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(4), JAK3(3), MAPK1(2), MAPK3(1), STAT3(2), TYK2(7)	9013253	20	10	20	3	6	0	2	6	5	1	0.164	0.732	1.000
99	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(1), BCAR1(3), CDKN1B(3), ILK(1), ITGB1(2), MAPK1(2), MAPK3(1), PTK2(2), SHC1(1), SOS1(4)	11274599	20	12	20	3	5	1	3	3	7	1	0.167	0.734	1.000
100	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25A(1), CDC25B(1), CHEK1(3), MYT1(7), WEE1(1), YWHAH(1)	10571537	22	13	22	6	3	2	2	4	11	0	0.688	0.737	1.000
101	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(2), AKT1(1), BAX(1), CSF2RB(2), IGF1(1), IGF1R(7), IL3(1), IL3RA(2), KIT(6), KITLG(2), PRKACG(1), PRKAR1A(2), YWHAH(1)	13930778	29	20	29	6	7	1	7	8	6	0	0.127	0.738	1.000
102	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(2)	11498575	26	12	25	5	7	3	6	6	4	0	0.0957	0.746	1.000
103	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), GLS(2), GLUD1(5), OAT(1)	4222368	10	6	10	3	2	1	0	4	3	0	0.540	0.746	1.000
104	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(4), AFMID(1), HAO1(2), HAO2(2), HYI(2), MTHFD1(2), MTHFD1L(1)	10271683	19	11	19	3	3	5	2	3	6	0	0.136	0.751	1.000
105	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSD(3), ARSE(3), ASAH1(1), GALC(1), GLA(2), GLB1(2), LCT(10), NEU1(1), NEU2(6), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(2), SMPD2(1), SPTLC1(3), SPTLC2(2), UGCG(2)	18565041	45	24	45	10	14	4	9	13	4	1	0.107	0.751	1.000
106	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(4)	2496561	6	6	6	3	2	1	1	1	1	0	0.706	0.753	1.000
107	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1), UXS1(2)	2931676	4	3	4	0	0	1	2	0	1	0	0.317	0.763	1.000
108	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(1), G6PC(7), GAPDHS(1), GCK(2), GOT1(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGK1(2), PKLR(2), TNFAIP1(2), TPI1(1)	32565460	68	40	67	8	27	19	3	10	9	0	1.42e-05	0.777	1.000
109	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(2), SHMT1(2)	4212834	4	4	4	1	1	1	2	0	0	0	0.463	0.785	1.000
110	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(3), CBS(4), CTH(1), MUT(1)	3767512	10	4	10	0	2	5	0	2	1	0	0.0264	0.788	1.000
111	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(1), ALAS2(1), FECH(1), PPOX(1), UROD(1), UROS(1)	5806910	8	5	8	1	2	2	1	3	0	0	0.243	0.789	1.000
112	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM3(1), CDKN1A(1), MARCKS(1), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), SP3(4), SYT1(2)	16106333	35	21	34	8	9	5	6	9	5	1	0.119	0.791	1.000
113	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(7), ATP4B(2), ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(10), ATP7B(4), COX10(3), COX6B1(1), COX7A1(1), NDUFA10(3), NDUFB5(1), NDUFS1(2), NDUFV1(2), NDUFV2(1), SDHA(4), SHMT1(2), UQCRC1(3), UQCRH(2)	29154375	59	33	58	9	11	10	12	17	8	1	0.00326	0.791	1.000
114	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	11	ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), PAK1(2), RAC1(1), WASL(2)	5655150	12	6	12	2	0	2	0	7	3	0	0.360	0.797	1.000
115	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), OXCT1(1)	2596524	2	2	2	0	0	1	0	1	0	0	0.592	0.800	1.000
116	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(2), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(10), MAN2C1(2), MANBA(1), NEU1(1), NEU2(6), NEU3(2)	12662054	32	23	32	8	8	3	6	10	5	0	0.312	0.800	1.000
117	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(4), HAO1(2), HAO2(2), HYI(2), MTHFD1(2), MTHFD1L(1)	9809602	18	10	18	3	3	5	2	3	5	0	0.139	0.800	1.000
118	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(5), LPO(5), MPO(2), TPO(6)	6410429	18	11	18	5	8	7	1	2	0	0	0.142	0.804	1.000
119	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(4), HK2(3), HK3(3), PGM3(1), TGDS(1)	7833826	14	9	14	2	6	4	2	1	1	0	0.0618	0.804	1.000
120	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(1), SNCA(1), SNCAIP(1), UBE2G2(1), UBE2L6(1)	4946758	8	8	8	3	5	1	0	1	1	0	0.481	0.805	1.000
121	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(1), GH1(1), GHR(4), NFKB1(1), NFKBIA(2), PPP2CA(4), RELA(1), YWHAH(1)	7891392	15	8	15	4	3	3	1	6	2	0	0.438	0.805	1.000
122	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), MBTPS1(2), MBTPS2(3), SCAP(2), SREBF1(6), SREBF2(3)	9188088	18	12	18	5	4	3	3	5	3	0	0.383	0.809	1.000
123	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(5), LPO(5), MPO(2), MTHFR(6), SHMT1(2), TPO(6)	8894149	30	13	30	8	11	9	3	5	2	0	0.101	0.814	1.000
124	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), RDH5(1)	2995139	2	2	2	1	0	2	0	0	0	0	0.705	0.815	1.000
125	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(4), CTH(1), GGT1(2), MARS(5), MARS2(2), SCLY(2), SEPHS1(1)	9489964	17	9	17	1	3	6	3	3	2	0	0.0123	0.823	1.000
126	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(2)	10762568	22	10	22	5	4	3	5	6	4	0	0.210	0.825	1.000
127	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(4), CYP11B2(1), HSD3B1(2), HSD3B2(1)	5293806	8	8	8	3	4	0	1	1	2	0	0.522	0.830	1.000
128	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(10), MAP2(7), PPP1CA(1), PPP2CA(4), PRKACG(1), PRKAG1(1)	13962992	24	12	24	4	4	4	2	8	6	0	0.224	0.833	1.000
129	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT1(4), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(2), GALNT14(4), GALNT2(2), GALNT3(1), GALNT4(3), GALNT5(3), GALNT6(3), GALNT7(1), GALNT8(1), GALNT9(2), GALNTL5(1), GCNT3(1), GCNT4(2), OGT(8), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(5)	24810260	55	33	54	11	16	11	5	16	7	0	0.0423	0.837	1.000
130	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(12), CPT1A(1), LEPR(2), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1)	11110749	22	10	22	2	6	3	1	7	5	0	0.0364	0.837	1.000
131	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(1), PLCB1(3), PLCG1(6), PRKCA(5), VAV1(5)	6948733	20	16	19	6	5	3	2	8	1	1	0.472	0.838	1.000
132	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	18	ACO1(5), ACO2(4), DLD(1), FH(1), IDH3B(1), PC(2), PCK1(3), SDHA(4), SUCLG2(1)	14543340	22	15	21	3	6	5	5	3	3	0	0.0337	0.840	1.000
133	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL5(1), MAF(3), MAP2K3(3), NFATC1(2), NFATC2(5), PRKACG(1), PRKAR1A(2)	9358111	20	13	20	6	8	1	3	6	2	0	0.311	0.840	1.000
134	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(2), ACADS(2), ECHS1(2), HADHA(2)	4142921	9	6	9	4	2	1	1	2	3	0	0.655	0.843	1.000
135	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(4), HK2(3), HK3(3), ISYNA1(2), PGM3(1), TGDS(1)	8942240	16	10	16	2	6	5	2	2	1	0	0.0330	0.844	1.000
136	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	FBP2(1), G6PC(7), GAA(5), GANAB(4), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(3), HK3(3), LCT(10), MGAM(8), PFKP(1), PGM3(1)	24926337	53	30	53	10	30	6	4	9	4	0	0.00767	0.848	1.000
137	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), BDH2(1), HMGCS1(2), HMGCS2(3), OXCT1(1)	5487350	9	4	9	0	1	3	0	4	1	0	0.0803	0.851	1.000
138	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(9), DAXX(2), PAX3(1), PML(3), RB1(7), SIRT1(1), SP100(4), TNF(1), TNFRSF1B(2)	13964936	30	15	30	5	6	3	4	8	9	0	0.144	0.854	1.000
139	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT1(2), LDHA(1), LDHB(2), LDHC(1)	5256692	7	4	7	1	1	4	0	2	0	0	0.259	0.855	1.000
140	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(2), RAB3A(1), RAB9A(1)	3252783	4	3	4	1	2	1	0	1	0	0	0.493	0.856	1.000
141	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GLB1(2), GUSB(3), HEXA(1), HEXB(1), IDS(2), LCT(10), NAGLU(3)	11032768	22	13	22	5	9	2	4	3	4	0	0.182	0.857	1.000
142	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(2), G6PC(7), G6PC2(1), GAA(5), GANC(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(3), HK3(3), HSD3B7(1), LCT(10), MGAM(8), PFKL(5), PFKP(1), PGM3(1), UGP2(1)	29566659	63	35	63	12	34	6	5	13	5	0	0.00447	0.860	1.000
143	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(3), ATG7(3), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(3), PRKAA1(3), PRKAA2(2), ULK1(1), ULK2(5)	16176760	30	13	30	3	6	2	8	9	5	0	0.0124	0.862	1.000
144	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11A1(4), CYP11B1(1), CYP11B2(1), HSD3B1(2), HSD3B2(1)	7079674	10	9	10	3	4	0	2	1	3	0	0.401	0.862	1.000
145	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11A1(4), CYP11B1(1), CYP11B2(1), HSD3B1(2), HSD3B2(1)	7079674	10	9	10	3	4	0	2	1	3	0	0.401	0.862	1.000
146	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(1), CDC25B(1), CSK(1), PRKCA(5), PTPRA(4)	7060597	14	7	14	4	6	2	3	2	0	1	0.340	0.864	1.000
147	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(3), FCGR3A(1), IL1B(2), IL6R(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2)	10008896	21	13	21	5	9	6	2	2	2	0	0.0957	0.865	1.000
148	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(1), IFNB1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(7)	8325437	15	8	15	4	4	0	1	7	2	1	0.498	0.866	1.000
149	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), ME1(1), PC(2), PDHA1(5), SLC25A1(1)	7109855	12	11	11	4	1	3	0	4	4	0	0.502	0.867	1.000
150	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(8), ATR(6), BRCA1(2), BRCA2(9), CHEK1(3), CHEK2(3), FANCA(4), FANCC(1), FANCD2(8), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(2), RAD50(5), RAD9A(3), TREX1(2)	33267544	63	34	62	11	14	15	11	14	9	0	0.0166	0.868	1.000
151	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(1), UXS1(2)	3740112	5	3	5	0	0	1	2	1	1	0	0.259	0.871	1.000
152	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(4), PRKACG(1), PRKAR1A(2), PRKCA(5)	7375801	14	11	14	4	6	0	1	5	1	1	0.629	0.872	1.000
153	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(2), RECK(3), TIMP1(1), TIMP3(1), TIMP4(2)	5775647	9	6	9	2	3	2	1	1	2	0	0.354	0.877	1.000
154	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1)	3630153	2	2	2	0	0	0	0	1	1	0	0.606	0.882	1.000
155	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(5), ITGAL(2), ITGB1(2), ITGB2(1), SELE(6)	9284705	21	17	20	8	8	4	6	1	2	0	0.412	0.886	1.000
156	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP68(2), SRP72(3), SRPR(5)	5799384	10	5	10	2	4	0	2	2	2	0	0.475	0.887	1.000
157	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(1)	6698395	12	5	12	3	3	3	2	3	1	0	0.415	0.888	1.000
158	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ARSE(3), ASAH1(1), B4GALT6(1), DEGS1(2), DEGS2(2), GALC(1), GLA(2), GLB1(2), LCT(10), NEU1(1), NEU2(6), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(2), SMPD2(1), SMPD3(2), SMPD4(1), SPTLC1(3), SPTLC2(2), UGCG(2), UGT8(1)	27354238	58	29	58	12	17	5	12	18	5	1	0.0475	0.889	1.000
159	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(3), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2)	20950367	51	35	50	12	12	5	11	21	2	0	0.117	0.889	1.000
160	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(5), ABCB11(1), ABCB4(6), ABCC1(5), ABCC3(6)	11003494	23	12	23	7	5	3	3	8	3	1	0.434	0.894	1.000
161	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(1)	5351407	5	4	5	1	0	0	1	2	2	0	0.604	0.897	1.000
162	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM3(1), CD3D(1), ELK1(3), FOS(1), FYN(1), LAT(2), LCK(1), MAP3K1(4), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIA(2), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), PTPN7(2), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(4), SYT1(2), VAV1(5), ZAP70(5)	33816769	72	38	71	15	20	13	7	19	11	2	0.0105	0.897	1.000
163	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(1), CDC25B(1), SHH(1), XPO1(1)	6658622	8	6	8	3	3	4	1	0	0	0	0.496	0.897	1.000
164	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(5), NRG2(1), PRKCA(5)	6924105	11	7	11	3	3	1	2	3	1	1	0.458	0.899	1.000
165	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(1), PON1(2), PON3(1)	6871905	11	7	10	4	5	0	1	3	2	0	0.671	0.902	1.000
166	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(4), CTH(1), GGT1(2), LCMT1(2), LCMT2(1), MARS(5), MARS2(2), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SCLY(2), SEPHS1(1), WBSCR22(2)	19114057	38	18	38	7	6	9	8	9	6	0	0.0350	0.904	1.000
167	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CDO1(1), CTH(1), GOT1(2), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), SDS(1), SULT1B1(2), SULT1C2(3)	9619319	15	8	15	4	3	5	1	4	2	0	0.388	0.905	1.000
168	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), MAPK1(2), MAPK8(2), NFE2L2(1), PRKCA(5)	6796384	12	8	12	3	2	2	3	1	3	1	0.230	0.906	1.000
169	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAK1(2), BAX(1), BCL2L11(1), CES1(1)	8308418	8	6	8	1	3	1	1	2	1	0	0.225	0.907	1.000
170	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(6), CREB1(1), DUSP4(1), DUSP9(2), EEF2K(2), EIF4E(2), MAP2K2(1), MAP3K8(4), MAPK1(2), MAPK3(1), MKNK1(2), NFKB1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), SHC1(1), SOS1(4), SOS2(5), TRAF3(2)	22652756	49	26	48	11	13	3	6	17	9	1	0.133	0.907	1.000
171	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(2), GREB1(7), MTA3(2), PDZK1(1), TUBA8(1)	8344839	15	8	15	3	6	3	1	3	2	0	0.181	0.912	1.000
172	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(1), RPN1(1), RPN2(1), UBE3A(1)	9890647	15	7	15	4	4	4	2	3	2	0	0.419	0.915	1.000
173	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4)	6131033	14	8	14	5	6	2	2	2	2	0	0.470	0.915	1.000
174	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4)	6131033	14	8	14	5	6	2	2	2	2	0	0.470	0.915	1.000
175	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP8(2), CFLAR(1), DAXX(2), DFFA(2), FAF1(3), LMNA(2), LMNB2(2), MAP3K1(4), MAPK8(2), PAK1(2), PAK2(2), PRKDC(11), PTPN13(3), RB1(7), RIPK2(1), SPTAN1(5)	31072941	52	29	52	9	10	10	9	12	10	1	0.0360	0.916	1.000
176	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(2), CREB1(1), SYT1(2)	8865394	16	7	16	4	4	5	4	0	3	0	0.170	0.916	1.000
177	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT2(1), AGPAT3(1), AGPS(3), CDS2(2), CHAT(4), CHKB(1), CLC(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), ETNK1(1), GNPAT(1), LGALS13(3), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(4), PLCG1(6), PLCG2(9), PPAP2A(2), PPAP2C(1)	38189756	81	49	80	17	25	18	10	17	11	0	0.00766	0.917	1.000
178	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(2), EGF(7), ELK1(3), FOS(1), JAK1(1), MAP3K1(4), MAPK3(1), MAPK8(2), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2), STAT1(2), STAT3(2), STAT5A(1)	23849655	49	32	48	11	14	9	4	12	7	3	0.0758	0.920	1.000
179	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3D(1), CD4(1)	2467483	3	2	3	2	1	1	0	1	0	0	0.810	0.926	1.000
180	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), CISH(1), IARS(1), IL13RA1(3), IL4R(2), INPP5D(2), JAK1(1), JAK2(4), JAK3(3), PI3(2), PPP1R13B(2), RPS6KB1(2), SERPINA4(2), SHC1(1), SOS1(4), SOS2(5), STAT6(4), TYK2(7)	26627012	47	27	47	7	12	4	7	15	9	0	0.0202	0.928	1.000
181	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(2), EHHADH(1), HADHA(2), SDS(1)	3699675	8	5	8	6	3	0	2	1	2	0	0.883	0.928	1.000
182	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(3), F2R(2), F5(7), F7(2), FGA(6), FGB(1), FGG(1), PROS1(1), SERPINC1(1)	12573981	25	20	25	8	9	1	6	7	2	0	0.404	0.929	1.000
183	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(7), MAPK1(2), MAPK3(1), PTPRB(7), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SPRY1(1), SPRY2(3), SPRY3(1), SPRY4(3)	17108465	36	24	36	8	11	2	4	7	11	1	0.195	0.933	1.000
184	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), UGDH(1)	6537836	16	8	16	4	8	2	2	2	2	0	0.236	0.935	1.000
185	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(2), AGTR2(3), CMA1(2), COL4A1(2), COL4A2(5), COL4A4(4), COL4A5(9), COL4A6(6), REN(2)	19293319	40	22	39	12	10	10	5	9	5	1	0.238	0.938	1.000
186	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	IL6(1), LPL(2)	4092143	3	3	3	0	0	0	0	3	0	0	0.585	0.939	1.000
187	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	11552717	13	9	13	3	3	5	3	1	0	1	0.198	0.939	1.000
188	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	11552717	13	9	13	3	3	5	3	1	0	1	0.198	0.939	1.000
189	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	11552717	13	9	13	3	3	5	3	1	0	1	0.198	0.939	1.000
190	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(1), ADRB2(1), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), DRD3(2), DRD5(3), HRH1(3), HTR1A(1), HTR1B(2), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1)	19720937	46	29	46	11	21	8	4	7	6	0	0.0119	0.940	1.000
191	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(2), AXIN1(1), BTRC(1), CCND1(4), CREBBP(9), CSNK1A1(2), CSNK1D(1), CSNK2A1(2), CTBP1(5), CTNNB1(3), FZD1(2), NLK(1), PPP2CA(4), WIF1(3)	22507040	40	20	40	6	10	5	5	12	8	0	0.0354	0.941	1.000
192	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(9), EP300(5), ESR1(2), MAPK1(2), MAPK3(1), PELP1(2)	11325441	21	10	20	4	9	1	2	5	3	1	0.161	0.944	1.000
193	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(3), BLNK(2), ELK1(3), FOS(1), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8IP3(4), PAPPA(4), RAC1(1), RPS6KA1(4), RPS6KA3(3), SHC1(1), SOS1(4), VAV1(5), VAV2(2), VAV3(2)	24556801	48	26	48	11	10	8	2	16	10	2	0.101	0.945	1.000
194	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(2), CASP8(2), DFFA(2), GZMB(1), PRF1(3), SCAP(2), SREBF1(6), SREBF2(3)	14000346	24	18	24	6	9	6	4	4	1	0	0.196	0.946	1.000
195	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CD4(1), CREBBP(9), CSK(1), GNAS(4), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PTPRC(7), ZAP70(5)	17651067	38	24	38	9	12	6	2	13	5	0	0.218	0.946	1.000
196	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CD4(1), CREBBP(9), CSK(1), GNAS(4), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PTPRC(7), ZAP70(5)	17651067	38	24	38	9	12	6	2	13	5	0	0.218	0.946	1.000
197	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), RAC1(1), WASF1(1), WASL(2)	6241477	11	5	11	3	0	2	1	7	1	0	0.524	0.950	1.000
198	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(2)	2884526	3	2	3	0	1	0	0	2	0	0	0.422	0.950	1.000
199	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(12), ACACB(11), ACADM(2), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ALDH7A1(2), ECHS1(2), EHHADH(1), HADHA(2), HIBCH(1), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), MLYCD(3), MUT(1), PCCA(1), PCCB(3), SUCLG2(1)	30434175	71	37	71	17	22	16	6	16	11	0	0.0395	0.950	1.000
200	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	IL1B(2), MST1R(2), TNF(1)	5022309	5	3	5	2	1	3	0	1	0	0	0.538	0.952	1.000
201	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMC3(1), PSMD1(1), PSMD11(2), PSMD2(3)	12284178	19	9	19	3	3	8	2	4	2	0	0.108	0.953	1.000
202	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY1(2), CSNK1E(1), PER1(5)	6537677	9	5	9	3	2	2	1	3	1	0	0.630	0.954	1.000
203	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(3), IFNGR2(1), IKBKB(1), JAK2(4), NFKB1(1), NFKBIA(2), RB1(7), RELA(1), TNF(1), TNFRSF1B(2), USH1C(2), WT1(1)	13269091	26	14	26	8	4	3	3	6	10	0	0.509	0.954	1.000
204	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(5), CPS1(3), EPRS(3), GAD1(2), GAD2(1), GCLC(1), GFPT1(4), GLS(2), GLS2(1), GLUD1(5), GLUL(1), GOT1(2), GSS(1), NADSYN1(4), PPAT(2), QARS(3)	25419296	44	24	44	7	10	7	6	12	9	0	0.0286	0.957	1.000
205	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CD4(1), IL12B(2), IL12RB1(2), IL12RB2(2), JAK2(4), STAT4(2), TYK2(7)	11280059	21	8	21	6	7	2	3	7	2	0	0.397	0.957	1.000
206	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), SULT1A2(1), SULT2A1(2), SUOX(1)	4692995	5	2	5	5	0	1	0	2	2	0	0.980	0.959	1.000
207	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD4(1), CD58(1), IL3(1), IL6(1), KITLG(2)	4730197	7	3	7	2	0	1	1	5	0	0	0.603	0.961	1.000
208	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(1), JAK1(1), JAK2(4), STAT1(2)	6282386	8	3	8	4	1	0	1	3	2	1	0.840	0.961	1.000
209	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(4), CDKN2A(4), E2F1(1), MDM2(3), POLR1A(5), POLR1B(2), RAC1(1), RB1(7), TBX2(1)	12054745	28	14	28	9	5	2	4	6	11	0	0.532	0.961	1.000
210	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), FDXR(1), SHMT1(2)	12288400	14	9	14	3	4	5	3	1	0	1	0.160	0.963	1.000
211	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(2), ELK1(3), FOS(1), JAK1(1), MAP3K1(4), MAPK3(1), MAPK8(2), PDGFA(1), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2), STAT1(2), STAT3(2), STAT5A(1)	22180629	43	28	42	10	11	8	4	11	6	3	0.102	0.963	1.000
212	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), NCKAP1(4), NTRK1(2), RAC1(1), WASF1(1), WASF2(1), WASF3(3), WASL(2)	11123070	21	11	21	6	3	4	3	9	2	0	0.406	0.965	1.000
213	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(4), JAK3(3), PIAS3(2), PTPRU(2), REG1A(2), STAT3(2)	11667939	19	14	19	5	4	1	2	6	6	0	0.364	0.966	1.000
214	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(2), FOS(1), JAK2(4), MAPK3(1), MPL(2), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), STAT1(2), STAT3(2), STAT5A(1), STAT5B(2), THPO(1)	20106368	39	25	38	9	9	6	4	11	6	3	0.132	0.968	1.000
215	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(2), ELK1(3), FOS(1), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(4)	11754235	22	16	21	6	3	7	2	5	4	1	0.242	0.969	1.000
216	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(3), DCN(2), FMOD(2), KERA(4), LUM(2)	2782871	13	11	13	6	1	2	3	6	1	0	0.756	0.970	1.000
217	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(1), CAT(3), EPX(5), LPO(5), MPO(2), PRDX1(1), SHMT1(2), TPO(6)	9053766	26	12	26	8	10	9	2	3	1	1	0.146	0.970	1.000
218	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(1), NTRK1(2), PLCG1(6), PRKCA(5), SHC1(1), SOS1(4)	9033693	19	15	18	5	4	3	3	5	3	1	0.397	0.971	1.000
219	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(4), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDH7A1(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(1), G6PC(7), G6PC2(1), GALM(1), GAPDHS(1), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGAM4(1), PGK1(2), PGM3(1), PKLR(2), TPI1(1)	44598644	98	53	97	21	38	19	8	21	12	0	0.00147	0.972	1.000
220	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(2), FARS2(3), GOT1(2), PAH(2), TAT(1), YARS(1)	6371064	14	6	14	3	7	3	1	1	2	0	0.243	0.973	1.000
221	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(1), TOB2(1)	8084133	14	7	14	4	5	4	1	3	1	0	0.320	0.974	1.000
222	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), PRKACG(1), PRKAG1(1)	7747858	10	6	10	4	2	0	1	5	2	0	0.791	0.974	1.000
223	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(2), AGTR2(3), KNG1(2), NOS3(7), REN(2)	7572529	20	15	19	8	9	2	2	4	3	0	0.674	0.974	1.000
224	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), IKBKB(1), MAP3K1(4), MAP3K5(3), MAP4K5(1), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), TNFRSF9(3), TNFSF9(2), TRAF2(2)	14842600	24	19	23	8	6	3	3	3	9	0	0.592	0.975	1.000
225	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC2(2), CASP1(5), CASP2(1), CASP4(1), CASP8(2), CYCS(2), DFFA(2), GZMB(1), LMNA(2), LMNB2(2), PRF1(3)	14811367	27	16	27	7	8	7	3	8	1	0	0.262	0.978	1.000
226	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(1), EIF4A1(6), EIF4A2(2), EIF4B(2), EIF4E(2), EIF4G1(4), EIF4G2(1), EIF4G3(6), MKNK1(2), PPP2CA(4), RPS6KB1(2), TSC1(2), TSC2(3)	17636298	37	25	37	9	10	8	6	9	4	0	0.165	0.980	1.000
227	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(5), ABCC2(1), ABCG2(1), CES1(1), CES2(2), CYP3A4(3), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2)	17545908	29	19	28	8	8	3	7	7	4	0	0.250	0.980	1.000
228	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), ELK1(3), EPO(1), EPOR(1), FOS(1), JAK2(4), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2)	16495935	30	20	29	8	4	7	4	9	5	1	0.205	0.981	1.000
229	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(2), HSD3B7(1)	3659485	5	5	5	3	2	0	0	3	0	0	0.876	0.981	1.000
230	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(3), GOT1(2), PAH(2), TAT(1), YARS(1)	6683013	9	6	9	3	3	3	1	1	1	0	0.552	0.981	1.000
231	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(1), HLA-DRA(3), HLA-DRB1(1), IFNB1(1), IL10(1), IL12B(2), IL15(2), IL3(1), IL5(1), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1), TNF(1)	10076046	19	12	19	6	4	2	4	7	2	0	0.468	0.981	1.000
232	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(1), HLA-DRA(3), HLA-DRB1(1), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL18(3), IL18R1(2), IL4R(2)	9713698	20	15	20	9	2	2	2	10	4	0	0.826	0.982	1.000
233	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(12), ACACB(11), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), DLD(1), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(1), ME1(1), ME2(1), ME3(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PKLR(2)	35881897	71	46	70	16	24	16	6	14	11	0	0.0181	0.982	1.000
234	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(3), FDFT1(1), FDPS(1), HMGCS1(2), IDI1(2), LSS(1), MVD(3), NSDHL(2), SQLE(1)	10097400	18	10	18	6	6	1	3	5	3	0	0.595	0.982	1.000
235	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(7), MAP3K1(4), NCOR2(8), RXRA(1), THRA(2), THRB(2)	11195903	24	18	23	8	9	4	1	5	5	0	0.452	0.982	1.000
236	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), FHL5(3), FSHR(2), GNAS(4), XPO1(1)	7359434	12	11	12	4	3	1	3	3	2	0	0.663	0.983	1.000
237	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(1), JAK2(4), JAK3(3), PIAS1(1), PIAS3(2), PTPRU(2), REG1A(2), SOAT1(2)	10505884	18	13	18	9	2	1	3	6	6	0	0.867	0.983	1.000
238	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), AR(4), ESR1(2), ESR2(3), ESRRA(2), HNF4A(3), NPM1(2), NR0B1(1), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(5), NR1I2(1), NR2C2(2), NR2E1(2), NR2F1(1), NR2F2(3), NR3C1(3), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(1), PGR(4), PPARA(3), PPARG(2), RARB(1), ROR1(3), RORA(1), RORC(1), RXRA(1), RXRG(3), THRA(2), THRB(2), VDR(2)	32251692	69	39	67	16	29	10	11	14	5	0	0.0217	0.983	1.000
239	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(1), IGF1R(7), IRS1(4), MAPK1(2), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), YWHAH(1)	11660001	22	16	22	5	5	4	3	3	6	1	0.151	0.984	1.000
240	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(7), EPHB1(2), FYN(1), ITGA1(2), ITGB1(2), L1CAM(7), SELP(2)	12110214	23	11	23	8	6	5	3	8	1	0	0.460	0.985	1.000
241	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(1), JAK1(1), PTPRU(2), REG1A(2), STAT1(2), STAT2(1), TYK2(7)	9574957	18	11	18	6	4	1	1	6	5	1	0.517	0.985	1.000
242	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(1), G6PC(7), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKP(1), PGK1(2), PGM3(1), PKLR(2), TPI1(1)	37455873	80	45	79	19	29	18	7	17	9	0	0.0109	0.986	1.000
243	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(1), G6PC(7), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKP(1), PGK1(2), PGM3(1), PKLR(2), TPI1(1)	37455873	80	45	79	19	29	18	7	17	9	0	0.0109	0.986	1.000
244	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(3), PLCB2(4), PRL(1), VIP(2)	8536635	18	15	18	6	6	4	0	5	3	0	0.497	0.986	1.000
245	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(3), NDUFB5(1), NDUFS1(2), NDUFV1(2), NDUFV2(1)	5333746	9	4	9	4	0	0	2	4	3	0	0.857	0.987	1.000
246	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(5), COL4A4(4), COL4A5(9), COL4A6(6), SLC23A1(1), SLC23A2(3), SLC2A1(2), SLC2A3(4)	19140819	36	20	36	10	12	7	5	8	3	1	0.100	0.987	1.000
247	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), ECHS1(2), HADHA(2), HSD17B4(2), MECR(1), PPT2(2)	6494079	12	8	12	6	2	1	2	3	4	0	0.824	0.988	1.000
248	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(2), ACADS(2), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(5), CPT1A(1), CPT2(1), EHHADH(1), HADHA(2), PECR(2), SCP2(1), SLC25A20(1)	12897180	26	15	26	7	2	6	2	7	9	0	0.306	0.988	1.000
249	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(2), ELK1(3), FOS(1), INSR(4), IRS1(4), MAPK3(1), MAPK8(2), PTPN11(7), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(4), SRF(2)	16666362	37	24	35	10	9	10	2	10	5	1	0.184	0.988	1.000
250	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(1), RAF1(1)	6311360	8	4	8	3	1	3	1	0	2	1	0.357	0.988	1.000
251	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	CHPF(1), CHST11(3), CHST13(2), CHST3(3), CHSY1(2), DSE(3), XYLT1(2), XYLT2(2)	10766638	18	12	18	5	7	2	1	6	2	0	0.354	0.988	1.000
252	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(1), FUT2(2), ST8SIA1(1)	4708422	4	2	4	4	1	0	0	1	2	0	0.991	0.989	1.000
253	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK1(1), JAK2(4), PTPRU(2), REG1A(2), STAT1(2)	8754459	12	6	12	6	2	1	1	3	4	1	0.733	0.989	1.000
254	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(3), MAP3K1(4), MAPK1(2), MAPK3(1), NFKB1(1), RB1(7), RELA(1)	12003539	22	10	22	8	6	2	4	2	7	1	0.655	0.990	1.000
255	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(1), BMPR1B(1)	4827084	6	5	6	4	3	0	1	1	1	0	0.955	0.990	1.000
256	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), ABAT(1), ACADS(2), ACAT2(1), ACSM1(6), AKR1B10(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH5A1(1), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HMGCS1(2), HMGCS2(3), HSD17B4(2), HSD3B7(1), ILVBL(5), L2HGDH(1), OXCT1(1), PDHA1(5), PDHA2(4), PDHB(1), PLA1A(3)	31061083	68	38	67	18	19	10	6	21	12	0	0.0782	0.990	1.000
257	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(9), EP300(5), LPL(2), NCOA1(2), NCOA2(2), PPARG(2), RXRA(1)	14174654	23	14	22	7	6	5	1	9	2	0	0.443	0.991	1.000
258	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), CASP8(2), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	6426744	12	11	12	5	4	3	1	1	3	0	0.638	0.991	1.000
259	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST13(2), SULT1A1(1), SULT1A2(1), SULT2A1(2), SULT2B1(2), SUOX(1)	7044200	13	9	13	6	2	1	0	7	3	0	0.840	0.991	1.000
260	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), SDS(1)	5971869	8	6	8	7	2	1	1	2	2	0	0.949	0.991	1.000
261	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(6), CPEB1(3), ERBB2(2), ERBB4(5), ETS1(4), ETV6(4), ETV7(1), FMN2(3), KRAS(3), MAPK1(2), MAPK3(1), NOTCH2(11), NOTCH3(6), NOTCH4(8), PIWIL2(3), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(4), SOS2(5), SPIRE1(1), SPIRE2(2)	34976923	79	44	78	18	20	13	12	20	12	2	0.0545	0.991	1.000
262	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), ABAT(1), ADSL(4), ADSSL1(1), AGXT(2), AGXT2(2), ASL(2), ASNS(3), ASPA(1), ASS1(3), CAD(5), CRAT(1), DARS2(2), DLD(1), GAD1(2), GAD2(1), GOT1(2), NARS(2), NARS2(1), PC(2), PDHA1(5), PDHA2(4), PDHB(1)	28997037	50	27	49	10	15	11	3	12	9	0	0.0342	0.992	1.000
263	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(1), FDPS(1), IDI1(2), LSS(1), MVD(3), NQO1(1), NQO2(1), SQLE(1)	8462946	14	7	14	5	4	1	3	3	3	0	0.614	0.992	1.000
264	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(1), XYLT1(2), XYLT2(2)	5035249	6	5	6	3	3	2	0	1	0	0	0.581	0.992	1.000
265	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(1), XYLT1(2), XYLT2(2)	5035249	6	5	6	3	3	2	0	1	0	0	0.581	0.992	1.000
266	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	25	ACLY(3), ACO1(5), ACO2(4), CLYBL(1), DLD(1), FH(1), IDH3B(1), OGDH(1), OGDHL(4), PC(2), PCK1(3), SDHA(4), SDHC(2), SUCLG2(1)	21641832	33	22	32	9	10	6	7	6	4	0	0.149	0.992	1.000
267	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(2), EHHADH(1), HADHA(2), HSD17B4(2), SIRT1(1), SIRT5(2), SIRT7(1)	9069287	13	9	13	9	3	0	2	4	4	0	0.957	0.992	1.000
268	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(1), ATP6V0C(1), DHFR(1), GART(4), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(2), MTR(2), SHMT1(2)	13722087	26	9	26	8	6	7	5	3	4	1	0.227	0.992	1.000
269	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), FOS(1), IL3(1), IL3RA(2), JAK2(4), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2)	13577246	20	11	20	5	3	2	3	7	4	1	0.312	0.993	1.000
270	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(1), ASAH1(1), ATF1(1), BRAF(6), CREB1(1), CREBBP(9), CRKL(1), DAG1(1), EGR1(2), EGR2(1), EGR3(1), ELK1(3), FRS2(1), MAP1B(8), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3C2G(1), PIK3CD(3), PTPN11(7), RPS6KA3(3), SHC1(1), TERF2IP(1), TH(3)	36530391	74	44	71	18	15	11	12	23	12	1	0.0588	0.993	1.000
271	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(5), CPS1(3), EARS2(1), EPRS(3), GAD1(2), GAD2(1), GCLC(1), GFPT1(4), GFPT2(3), GLS(2), GLS2(1), GLUD1(5), GLUD2(1), GLUL(1), GNPNAT1(2), GOT1(2), GSS(1), NADSYN1(4), PPAT(2), QARS(3)	30252374	51	28	51	11	10	9	7	14	11	0	0.0885	0.993	1.000
272	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(3), ACAT2(1), ECHS1(2), EHHADH(1), HADHA(2), SDS(1)	6411457	10	8	10	9	2	1	2	2	3	0	0.970	0.993	1.000
273	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(1), CHEK1(3), NEK1(2), WEE1(1)	5276157	9	7	9	4	4	2	2	0	1	0	0.817	0.993	1.000
274	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(1), EPO(1), EPOR(1), GRIN1(2), JAK2(4), NFKB1(1), NFKBIA(2), RELA(1), SOD2(1)	9705450	15	9	15	5	4	1	1	6	3	0	0.589	0.993	1.000
275	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(1), AP2M1(1), BIN1(2), CALM3(1), DNM1(1), EPN1(1), EPS15(1), PICALM(2), PPP3CA(1), PPP3CC(1), SYNJ1(6), SYNJ2(8), SYT1(2)	16487989	28	13	28	8	7	5	6	4	6	0	0.273	0.993	1.000
276	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(6), BCAR1(3), CSK(1), CTNNA2(3), CTNNB1(3), PTK2(2), VCL(1)	14709559	20	11	20	5	9	3	2	2	4	0	0.272	0.993	1.000
277	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(5), RELA(1)	6316116	12	9	12	7	3	0	1	6	1	1	0.889	0.993	1.000
278	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(12), ACAT2(1), ADH5(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), DLD(1), LDHA(1), LDHB(2), LDHC(1), LDHD(1), ME1(1), ME2(1), ME3(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PKLR(2)	28371080	54	35	53	13	15	14	5	11	9	0	0.0641	0.993	1.000
279	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(2), GLB1(2), HEXA(1), HEXB(1), LCT(10), SLC33A1(3), ST3GAL1(2), ST3GAL2(1), ST6GALNAC3(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(3)	12649081	29	18	29	9	11	1	4	5	8	0	0.581	0.994	1.000
280	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), FPGT(2), GCK(2), GMDS(1), GMPPA(2), HK1(4), HK2(3), HK3(3), MPI(2), PFKFB1(4), PFKFB3(2), PFKP(1), SORD(1), TPI1(1)	18328412	32	15	32	8	12	9	1	6	4	0	0.0674	0.994	1.000
281	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(3), DLG4(3), EPHB2(2), F2(3), F2RL1(4), F2RL3(1), MAP2K5(2), MAPK1(2), MAPK7(5), MAPK8(2), MYEF2(3), PLD1(7), PLD3(1), PTK2(2), RAF1(1), RASAL1(4), TEC(3), VAV1(5)	21051988	53	32	52	14	16	8	6	15	8	0	0.120	0.994	1.000
282	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(1), BRAF(6), CAB39(2), EIF4B(2), IGF1(1), MAPK1(2), MAPK3(1), PGF(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PRKAA1(3), PRKAA2(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(3), RPS6KB1(2), RPS6KB2(3), STK11(1), TSC1(2), TSC2(3), ULK1(1), ULK2(5), VEGFA(2), VEGFB(2), VEGFC(2)	37859685	72	40	70	16	18	7	13	22	11	1	0.0557	0.994	1.000
283	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(8), ATR(6), CHEK1(3), CHEK2(3), YWHAH(1)	11670702	21	10	21	5	4	4	3	5	5	0	0.423	0.994	1.000
284	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(1), ADSL(4), AGXT(2), AGXT2(2), ASL(2), ASNS(3), ASPA(1), CAD(5), CRAT(1), GAD1(2), GAD2(1), GOT1(2), NARS(2), PC(2)	19972600	32	14	32	5	9	7	1	9	6	0	0.0399	0.995	1.000
285	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), ST8SIA1(1)	4329563	7	7	7	4	3	0	1	2	1	0	0.892	0.995	1.000
286	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS1(1), ALAS2(1), BLVRA(2), COX10(3), COX15(1), CP(3), EARS2(1), EPRS(3), FECH(1), FTH1(3), GUSB(3), HCCS(4), MMAB(2), PPOX(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2), UROD(1), UROS(1)	32362879	79	51	78	20	20	10	17	30	2	0	0.0833	0.996	1.000
287	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AGPAT2(1), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), CEL(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), GK(1), GLA(2), GLB1(2), LCT(10), LIPC(1), LIPG(3), LPL(2), PNLIP(2), PNLIPRP1(4), PPAP2A(2), PPAP2C(1)	36849046	78	36	78	20	28	10	13	20	7	0	0.0374	0.996	1.000
288	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(4), PRKAR1A(2)	5069121	8	8	8	4	4	0	0	2	2	0	0.866	0.996	1.000
289	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), CDKN1A(1), ELK1(3), MAP2K2(1), NGFR(1), NTRK1(2), PIK3CD(3), SHC1(1), SOS1(4)	10689433	17	10	17	5	6	2	1	5	3	0	0.423	0.996	1.000
290	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ARG2(2), ASL(2), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), GLUD1(5), OAT(1), ODC1(3), SMS(1)	13415477	24	12	24	6	5	4	0	6	9	0	0.329	0.997	1.000
291	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP2CA(4), PPP3CA(1), PRKACG(1), PRKAR1A(2)	12311457	17	10	17	6	4	2	1	9	1	0	0.717	0.997	1.000
292	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(12), ACADL(1), ACADM(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ECHS1(2), EHHADH(1), HADHA(2), LDHA(1), LDHB(2), LDHC(1), MLYCD(3), MUT(1), PCCA(1), PCCB(3), SDS(1), SUCLG2(1)	25406954	54	26	54	14	14	14	4	13	9	0	0.128	0.997	1.000
293	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(3), CALM3(1), ELK1(3), FCER1A(2), FOS(1), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PAK2(2), PLA2G4A(4), PLCG1(6), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(4), SYT1(2), VAV1(5)	30153159	59	31	58	14	12	12	9	18	7	1	0.0506	0.997	1.000
294	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(2), CDH1(4), CREBBP(9), EP300(5), MAPK3(1), SKIL(3), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3)	19708504	32	13	32	7	9	4	3	12	3	1	0.220	0.997	1.000
295	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM3(1), CRKL(1), MAP2K2(1), MAP2K3(3), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(6), PRKCA(5), PTK2B(2), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(2)	21880324	42	26	41	11	9	9	7	7	8	2	0.107	0.997	1.000
296	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(2), RPL10L(2), RPL13A(1), RPL18A(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(2), RPS2(1), RPS24(1), RPS3(3)	17273282	24	12	24	3	9	1	3	7	4	0	0.156	0.997	1.000
297	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT2(2), GBGT1(1), GLA(2), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), ST8SIA1(1)	7752310	15	9	15	6	5	1	1	4	4	0	0.793	0.998	1.000
298	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACPP(4), ALPI(1), ALPP(5), ALPPL2(2), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2A7(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(2), CYP4B1(1), CYP51A1(2), PON1(2)	22412447	43	35	43	10	17	3	4	9	10	0	0.149	0.998	1.000
299	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(3), APOBEC3B(1), APOBEC3C(1), APOBEC3F(2), APOBEC3G(1), APOBEC4(1)	5628441	13	12	13	5	4	3	0	5	1	0	0.612	0.998	1.000
300	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(1), ESCO2(2), PNPLA3(1), SH3GLB1(3)	12719180	12	5	11	1	5	3	1	2	1	0	0.0852	0.998	1.000
301	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), RAC1(1), RAF1(1), RALA(2), RALBP1(2), RALGDS(2), RELA(1)	11709872	16	6	16	8	3	1	1	4	6	1	0.816	0.998	1.000
302	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), APAF1(3), ATM(8), BAX(1), CYCS(2), PRKCA(5), PTK2(2), STAT1(2), TLN1(5)	20370666	29	17	29	7	6	2	4	11	4	2	0.285	0.998	1.000
303	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(6), BAIAP2(3), CASP1(5), CASP8(2), INSR(4), MAGI1(4), MAGI2(4), RERE(7), WWP1(3), WWP2(1)	18383027	39	23	39	11	13	8	3	11	4	0	0.280	0.998	1.000
304	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(1), IARS2(3), ILVBL(5), LARS(4), PDHA1(5), PDHA2(4), PDHB(1), VARS(3), VARS2(2)	14233841	29	17	28	8	5	7	2	10	5	0	0.367	0.998	1.000
305	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), FUT1(1), FUT2(2), GBGT1(1), GLA(2), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL2(1), ST8SIA1(1)	8229760	13	6	13	8	4	1	1	3	4	0	0.950	0.999	1.000
306	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(2), ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), FPGT(2), GMDS(1), GMPPA(2), HK1(4), HK2(3), HK3(3), HSD3B7(1), MPI(2), MTMR1(4), MTMR2(3), MTMR6(1), PFKFB1(4), PFKFB2(2), PFKFB3(2), PFKL(5), PFKP(1), PGM2(4), SORD(1), TPI1(1), TSTA3(1)	28474586	53	26	53	13	20	10	4	11	8	0	0.0572	0.999	1.000
307	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(4), HSD17B4(2), HSD17B7(2), HSD3B1(2), HSD3B2(1)	6213529	11	11	10	6	2	3	3	2	1	0	0.758	0.999	1.000
308	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(1), GLUD1(5), GLUD2(1)	3498124	9	7	9	4	1	2	0	4	2	0	0.768	0.999	1.000
309	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(3), CALM3(1), CD79A(1), ELK1(3), FOS(1), MAP3K1(4), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(2), VAV1(5)	29338010	58	29	57	15	14	11	6	16	9	2	0.0883	0.999	1.000
310	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(1), CREB1(1), MAPK1(2), MAPK3(1), MAPK7(5), MEF2A(2), MEF2B(1), NTRK1(2), PLCG1(6), RPS6KA1(4), SHC1(1)	11608558	26	17	25	9	3	5	3	7	7	1	0.583	0.999	1.000
311	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3D(1), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(2), ITGB2(1), PRF1(3)	6704208	11	8	11	7	8	2	0	0	1	0	0.731	0.999	1.000
312	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	HLA-A(1), IL18(3), ITGB1(2), KLRC1(2), KLRC2(1), KLRC4(1), LAT(2), MAPK3(1), PAK1(2), PTK2B(2), RAC1(1), VAV1(5)	11395557	23	12	23	7	5	3	3	5	6	1	0.349	0.999	1.000
313	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(3), PIGA(3), PIGB(1), PIGC(1), PIGG(2), PIGN(1), PIGO(3), PIGQ(3), PIGS(2), PIGT(1), PIGU(1), PIGW(2), PIGX(1), PIGZ(1)	18249902	27	9	27	8	10	2	5	6	4	0	0.316	0.999	1.000
314	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(2), GZMB(1), HMGB2(1), TOP2A(4), TOP2B(3)	6803177	11	6	11	5	5	1	1	3	1	0	0.797	0.999	1.000
315	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(1), LARS(4), PDHA1(5), PDHA2(4), PDHB(1)	7685277	16	11	15	6	1	5	2	4	4	0	0.627	0.999	1.000
316	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), F2R(2), F2RL3(1), GNAI1(4), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), PLA2G4A(4), PLCB1(3), PRKCA(5), PTGS1(2), PTK2(2), RAF1(1), TBXAS1(2)	18702912	36	25	36	10	5	1	9	14	5	2	0.333	0.999	1.000
317	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1), YWHAH(1)	5904113	7	3	7	4	1	2	1	0	3	0	0.869	0.999	1.000
318	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CYP2C19(4), CYP2C9(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(2), EHHADH(1), ESCO1(1), ESCO2(2), HADHA(2), PNPLA3(1), SH3GLB1(3)	23702376	42	22	41	11	18	7	5	6	6	0	0.125	0.999	1.000
319	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(2), EIF2S2(1), NFKB1(1), NFKBIA(2), RELA(1)	6855660	7	4	7	4	1	2	0	3	1	0	0.846	0.999	1.000
320	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4), GPHN(1), NSF(2), UBQLN1(2)	9183009	28	19	28	10	5	8	3	7	5	0	0.551	0.999	1.000
321	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), GLI2(3), GLI3(7), PRKACG(1), PRKAR1A(2), SHH(1), SMO(2), SUFU(3)	12777072	22	12	22	9	5	6	2	6	3	0	0.594	0.999	1.000
322	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(2), GPR161(1), GPR171(1), GPR18(2), GPR34(2), GPR45(1), GPR75(1)	7553131	13	7	13	9	4	2	2	2	3	0	0.881	0.999	1.000
323	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA2(3), ACADM(2), ACADS(2), ACAT2(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ALDH7A1(2), AOX1(5), BCAT1(1), BCKDHA(1), BCKDHB(1), DBT(2), DLD(1), ECHS1(2), EHHADH(1), HADHA(2), HIBADH(1), HIBCH(1), HMGCS1(2), HMGCS2(3), HSD17B4(2), MCCC1(2), MCCC2(5), MUT(1), OXCT1(1), PCCA(1), PCCB(3)	32956682	66	33	65	17	20	14	6	14	12	0	0.100	0.999	1.000
324	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AGK(1), AGPAT2(1), AGPAT3(1), AGPAT6(1), AKR1A1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CEL(2), DAK(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), GK(1), GK2(4), GLA(2), GLB1(2), GPAM(1), LCT(10), LIPA(2), LIPC(1), LIPG(3), LPL(2), MGLL(1), PNLIP(2), PNLIPRP1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1)	44894032	93	41	93	24	34	10	16	25	8	0	0.0348	0.999	1.000
325	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(2), CRADD(1), DFFA(2), LMNA(2), LMNB2(2), MADD(2), MAP3K1(4), MAPK8(2), PAK1(2), PAK2(2), PRKDC(11), RB1(7), RIPK1(3), SPTAN1(5), TNF(1), TRADD(1), TRAF2(2)	29620524	54	37	54	12	13	10	9	10	11	1	0.0999	0.999	1.000
326	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(3), DPAGT1(2), DPM1(2), FUT8(6), MAN1A1(2), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), RPN1(1), RPN2(1), ST6GAL1(1)	15248910	31	18	31	9	6	10	5	3	7	0	0.203	0.999	1.000
327	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(2), ITGAM(2), ITGB2(1), SELE(6)	7957469	16	13	15	8	8	4	3	0	1	0	0.567	0.999	1.000
328	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4R(2), IRS1(4), JAK1(1), JAK3(3), RPS6KB1(2), SHC1(1), STAT6(4)	11338598	18	13	18	6	3	3	1	7	4	0	0.556	0.999	1.000
329	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), AKT1(1), ANXA1(2), CALM3(1), GNAS(4), NFKB1(1), NOS3(7), NR3C1(3), RELA(1), SYT1(2)	10828575	23	16	23	8	10	3	4	4	2	0	0.538	0.999	1.000
330	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(7), PRKACG(1), PRKAR1A(2)	9893889	14	11	14	5	4	1	2	5	1	1	0.561	1.000	1.000
331	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(2), ATF2(2), AXIN1(1), BMP10(2), BMP4(2), BMP5(4), BMPR1A(1), CHRD(1), CTNNB1(3), FZD1(2), GATA4(1), MYL2(2), RFC1(1), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2)	27899952	37	21	37	9	13	5	4	5	10	0	0.210	1.000	1.000
332	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CASP8(2), CYCS(2), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(3), SMPD1(2), TRADD(1), TRAF2(2)	15737317	26	18	26	9	6	5	4	4	6	1	0.449	1.000	1.000
333	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(1), CDK2(1), CDKN1B(3), CDKN2A(4), CREB1(1), ERBB4(5), IGF1(1), INPPL1(5), IRS1(4), IRS2(1), IRS4(6), MET(10), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PARD3(2), PARD6A(1), PDK1(2), PIK3CD(3), PPP1R13B(2), PREX1(5), PTK2(2), PTPN1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(5), TSC1(2), TSC2(3), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	56919534	114	58	114	26	23	16	21	34	20	0	0.0163	1.000	1.000
334	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(4), PPP2CA(4), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(2)	11779304	20	11	20	6	8	1	0	8	3	0	0.591	1.000	1.000
335	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(1), BCR(3), CRKL(1), FOS(1), JAK2(4), MAP3K1(4), MAPK3(1), MAPK8(2), RAF1(1), SOS1(4), STAT1(2), STAT5A(1), STAT5B(2)	18669601	27	13	27	8	6	6	3	7	3	2	0.239	1.000	1.000
336	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(1), ASAH1(1), BRAF(6), DAG1(1), EPHB2(2), ITPR1(4), ITPR2(13), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), PI3(2), PIK3CB(3), PITX2(4), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), RAF1(1), SHC1(1), SOS1(4), SOS2(5), STAT3(2), TERF2IP(1)	42845391	85	46	84	21	22	8	19	28	7	1	0.0664	1.000	1.000
337	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), NFKB1(1), NOX1(1), RELA(1), TNF(1), XDH(8)	7598377	13	6	13	7	3	4	0	5	1	0	0.782	1.000	1.000
338	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1), PPP2CA(4)	7096862	12	4	12	5	3	1	3	4	1	0	0.746	1.000	1.000
339	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	FURIN(1)	3992696	1	1	1	1	1	0	0	0	0	0	0.944	1.000	1.000
340	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(1), GNAS(4), PLCE1(8), PRKACG(1), PRKAR1A(2), RAP2B(2)	11343965	20	15	20	7	9	4	1	3	3	0	0.540	1.000	1.000
341	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(2), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2), TRAF6(1)	8497832	13	8	13	8	1	3	2	6	1	0	0.904	1.000	1.000
342	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), EPO(1), IL3(1), IL5(1), IL6(1), IL9(1)	4572621	6	4	6	5	1	0	0	4	1	0	0.961	1.000	1.000
343	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(5), AKT1(1), ATM(8), BAX(1), CDKN1A(1), CPB2(1), CSNK1A1(2), CSNK1D(1), MAPK8(2), MDM2(3), NQO1(1)	15317147	26	15	26	9	5	2	3	11	5	0	0.694	1.000	1.000
344	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	48	AGT(2), AKT1(1), CALM3(1), CALR(2), CAMK1(1), CAMK1G(1), CAMK4(2), CREBBP(9), CSNK1A1(2), F2(3), GATA4(1), IGF1(1), MAPK1(2), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RAF1(1), RPS6KB1(2), SYT1(2)	33018267	54	26	54	14	14	7	9	14	9	1	0.0779	1.000	1.000
345	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(1), CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(4), GRAP2(1), ITK(1), LAT(2), LCK(1), LCP2(1), MAPK1(2), NFAT5(4), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PLCG1(6), PTPRC(7), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(2), SOS1(4), SOS2(5), VAV1(5), ZAP70(5)	42085046	86	49	85	20	24	18	10	21	13	0	0.0311	1.000	1.000
346	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(1), DHFR(1), FTCD(4), GART(4), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(2), MTR(2), SHMT1(2)	14514574	30	13	30	10	8	7	5	4	5	1	0.303	1.000	1.000
347	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(1), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MAPKAPK5(2), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PIK3CD(3), SYT1(2), TRAF2(2), TRAF3(2), TRAF5(3), TRAF6(1)	22868155	40	25	40	11	14	5	7	8	5	1	0.124	1.000	1.000
348	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(1), CFTR(4), GNAS(4), PRKACG(1), PRKAR1A(2), SLC9A3R1(1)	10042842	15	13	15	5	7	2	1	3	2	0	0.550	1.000	1.000
349	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	CES1(1)	4633326	1	1	1	1	0	1	0	0	0	0	0.829	1.000	1.000
350	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), EPRS(3), FARS2(3), GARS(3), HARS(2), IARS(1), LARS(4), MARS(5), MARS2(2), NARS(2), QARS(3), RARS(2), SARS(1), WARS2(2), YARS(1)	24580717	36	17	36	9	6	10	3	11	6	0	0.294	1.000	1.000
351	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(1), CHRNB1(2), CHRNG(2), MUSK(4), PTK2(2), PTK2B(2), RAPSN(1), TERT(3), YWHAH(1)	9609315	18	13	18	8	6	1	2	6	3	0	0.751	1.000	1.000
352	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(2), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(3), ALG6(3), DAD1(1), DHDDS(1), DOLPP1(1), DPAGT1(2), DPM1(2), FUT8(6), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), MGAT5B(1), RPN1(1), RPN2(1), ST6GAL1(1), STT3B(2)	32433571	60	32	60	15	12	16	10	8	14	0	0.0964	1.000	1.000
353	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1)	10369583	16	11	16	6	5	2	2	6	1	0	0.626	1.000	1.000
354	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(5), RAF1(1), RELA(1), TNF(1)	11915064	18	13	18	9	3	2	2	6	3	2	0.708	1.000	1.000
355	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(8), ATR(6), BAI1(5), BAX(1), CASP8(2), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(4), CCNE1(1), CCNE2(1), CCNG2(2), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN2A(4), CHEK1(3), CHEK2(3), CYCS(2), DDB2(2), EI24(4), FAS(1), GTSE1(4), IGF1(1), MDM2(3), MDM4(1), PPM1D(3), RCHY1(1), RFWD2(4), RRM2B(1), SERPINB5(1), SERPINE1(2), SESN1(1), SESN2(1), SESN3(1), SFN(2), SIAH1(3), STEAP3(2), THBS1(4), TP53I3(1), TSC2(3), ZMAT3(3)	48795177	105	61	104	27	21	15	20	28	21	0	0.0615	1.000	1.000
356	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(2), AKT1(1), ASAH1(1), GNAI1(4), ITGAV(3), ITGB3(2), MAPK1(2), MAPK3(1), PDGFA(1), PLCB1(3), PRKCA(5), PTK2(2), RAC1(1), SMPD1(2), SMPD2(1)	16421367	31	19	31	10	6	1	8	6	8	2	0.403	1.000	1.000
357	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	11	CBS(4), CTH(1), DNMT1(3), DNMT3B(4), MARS(5), MARS2(2), MTR(2)	11948653	21	8	21	9	5	6	0	6	2	2	0.618	1.000	1.000
358	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(5), PDHA2(4), PDHB(1), SDS(1)	19786610	42	26	41	14	13	7	4	9	9	0	0.233	1.000	1.000
359	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX15(2), ALOX5(2), CYP1A2(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(2), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	18301934	40	30	40	12	14	5	5	8	8	0	0.305	1.000	1.000
360	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM3(1), CXCR4(2), FOS(1), MAPK8(2), PLCG1(6), PRKCA(5), PTK2B(2), SYT1(2)	10581180	21	18	20	9	3	6	6	4	1	1	0.530	1.000	1.000
361	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	ELK1(3), GNAS(4), IGF1R(7), ITGB1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(2), NGFR(1), PPP2CA(4), PTPRR(3), RAF1(1), RPS6KA1(4), RPS6KA5(1), SHC1(1), SOS1(4), STAT3(2)	21611842	43	28	43	12	13	4	6	10	9	1	0.256	1.000	1.000
362	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(6), CALM3(1), CAPNS1(1), CAPNS2(1), EP300(5), HDAC2(4), NFATC1(2), NFATC2(5), PPP3CA(1), PPP3CC(1), PRKCA(5), SYT1(2)	18701070	34	17	34	11	9	4	6	8	6	1	0.421	1.000	1.000
363	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), AOX1(5), DBH(3), DDC(3), FAH(2), GOT1(2), GSTZ1(3), HGD(5), HPD(1), MAOA(2), TAT(1), TH(3), TPO(6), TYR(4)	24287774	60	33	60	20	22	7	6	19	6	0	0.253	1.000	1.000
364	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(1), BRD4(1), CBL(1), CDKN2A(4), FLOT2(3), INPPL1(5), IRS1(4), IRS2(1), IRS4(6), LNPEP(2), MAPK1(2), MAPK3(1), PARD3(2), PARD6A(1), PDK1(2), PIK3CD(3), PTPN1(1), RAF1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(4), SOS2(5), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	42125326	75	40	75	18	14	9	12	25	14	1	0.0735	1.000	1.000
365	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(2), ATF2(2), CALM3(1), ELK1(3), MAP2K2(1), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8(2), MEF2A(2), MEF2B(1), PAK1(2), PRKCA(5), PTK2(2), PTK2B(2), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(2)	23677326	41	21	41	12	7	7	6	8	11	2	0.250	1.000	1.000
366	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CREB1(1), DAXX(2), DDIT3(2), ELK1(3), MAP3K1(4), MAP3K5(3), MAP3K9(3), MAPKAPK2(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), MKNK1(2), PLA2G4A(4), RAC1(1), RIPK1(3), RPS6KA5(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	28090078	52	31	50	14	14	8	8	12	9	1	0.218	1.000	1.000
367	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10(1), IL10RB(1), IL6(1), JAK1(1), STAT1(2), STAT3(2), STAT5A(1), TNF(1)	9319196	12	7	12	6	3	1	2	5	0	1	0.784	1.000	1.000
368	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(2), AXIN1(1), BTRC(1), CTNNB1(3), FZD1(2)	13296887	9	6	9	5	2	1	1	2	3	0	0.920	1.000	1.000
369	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GHR(4), INSR(4), IRS1(4), JAK2(4), MAPK1(2), MAPK3(1), PLCG1(6), PRKCA(5), RAF1(1), RPS6KA1(4), SHC1(1), SLC2A4(1), SOS1(4), SRF(2), STAT5A(1), STAT5B(2)	22492134	47	29	46	14	9	10	6	13	7	2	0.256	1.000	1.000
370	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM3(1), EGR2(1), EGR3(1), MAP3K1(4), NFATC1(2), NFATC2(5), NFKB1(1), NFKBIA(2), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RELA(1), SYT1(2), VIP(2), VIPR2(1)	21487235	34	23	33	11	7	5	3	14	5	0	0.471	1.000	1.000
371	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(2), BAX(1), BFAR(1), BTK(3), CAD(5), CASP8(2), CD7(1), CSNK1A1(2), DAXX(2), DEDD2(1), DFFA(2), DIABLO(1), EPHB2(2), FAF1(3), MAP3K1(4), MAP3K5(3), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MET(10), NFAT5(4), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PTPN13(3), RALBP1(2), RIPK1(3), ROCK1(2), SMPD1(2), TNFRSF6B(1), TPX2(5), TRAF2(2)	53092571	89	46	89	20	26	15	13	16	19	0	0.0172	1.000	1.000
372	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDH7A1(2), AMDHD1(2), ASPA(1), CNDP1(2), DDC(3), FTCD(4), HAL(1), HARS(2), HARS2(1), HDC(2), HNMT(1), LCMT1(2), LCMT2(1), MAOA(2), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(1), WBSCR22(2)	30370803	64	35	64	20	25	9	9	14	7	0	0.169	1.000	1.000
373	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAPK8(2), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TNFSF13B(1), TRAF2(2), TRAF3(2), TRAF5(3), TRAF6(1)	11140174	15	10	15	7	6	4	2	2	1	0	0.713	1.000	1.000
374	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	EPO(1), FLT3(4), IGF1(1), IL3(1), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1)	6234686	14	7	14	6	3	1	3	5	2	0	0.728	1.000	1.000
375	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), ETV5(2), IL12B(2), IL12RB1(2), IL12RB2(2), IL18(3), IL18R1(2), JAK2(4), MAPK8(2), STAT4(2), TYK2(7)	14316280	29	15	29	10	8	3	6	10	2	0	0.543	1.000	1.000
376	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(4), NFKB1(1), NFKBIA(2), RELA(1), TNFAIP3(2), TRAF3(2), TRAF6(1)	13905406	16	11	16	9	8	1	1	4	2	0	0.846	1.000	1.000
377	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT2(1), AGPAT3(1), AGPAT6(1), CDS2(2), CHAT(4), CHKB(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), ESCO1(1), ESCO2(2), ETNK1(1), ETNK2(2), GNPAT(1), GPAM(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PHOSPHO1(1), PISD(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(7), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(2), SH3GLB1(3)	50146120	72	33	72	16	23	18	8	14	9	0	0.0121	1.000	1.000
378	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(1), CABIN1(6), CALM3(1), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1(1), IGF1R(7), INSR(4), MAPK7(5), MEF2A(2), MEF2B(1), NFATC1(2), NFATC2(5), PPP3CA(1), PPP3CC(1), SYT1(2), YWHAH(1)	23782270	43	23	43	14	13	7	7	9	7	0	0.271	1.000	1.000
379	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(12), ACACB(11), FASN(3), MCAT(2), OXSM(2)	12091609	30	21	30	11	8	5	4	7	6	0	0.451	1.000	1.000
380	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(5), CR2(5), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7)	11659594	26	19	26	10	8	6	1	6	5	0	0.501	1.000	1.000
381	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(1), BCR(3), BTK(3), CD19(1), CDKN2A(4), FLOT2(3), ITPR1(4), ITPR2(13), ITPR3(13), PDK1(2), PHF11(1), PITX2(4), PLCG2(9), PPP1R13B(2), PREX1(5), PTPRC(7), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), SAG(2), TEC(3), VAV1(5)	40008045	98	53	98	29	30	14	14	29	10	1	0.105	1.000	1.000
382	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM3(1), CREB1(1), ELK1(3), FOS(1), GNAI1(4), GNAS(4), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), RAF1(1), RPS6KA3(3), SYT1(2)	26832453	52	34	51	16	13	6	8	13	10	2	0.285	1.000	1.000
383	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(3), CLTA(1), COPA(2), GBF1(4), GPLD1(1), KDELR2(1), KDELR3(1)	12447578	14	8	14	7	2	4	3	2	3	0	0.772	1.000	1.000
384	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM3(1), DLG4(3), GRIN1(2), GRIN2A(8), GRIN2B(7), GRIN2C(4), GRIN2D(4), NOS1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), SYT1(2)	19576230	47	36	47	17	17	8	7	10	4	1	0.330	1.000	1.000
385	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(3), CALM3(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), F2(3), FYN(1), GNA11(1), GNAI1(4), JAK2(4), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(2), MYLK(5), PLCG1(6), PRKCA(5), PTK2B(2), RAF1(1), SHC1(1), SOS1(4), STAT1(2), STAT3(2), STAT5A(1), SYT1(2)	31956855	61	35	60	18	15	8	13	14	8	3	0.159	1.000	1.000
386	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(2), ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), CFL1(1), CFL2(1), FLNA(13), FLNC(12), FSCN1(2), FSCN2(1), FSCN3(3), GDI1(3), GDI2(1), LIMK1(4), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), RHO(1), ROCK1(2), ROCK2(4), RPS4X(2), WASF1(1), WASL(2)	33679680	83	44	83	27	28	13	11	21	9	1	0.171	1.000	1.000
387	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	ACO2(4), FH(1), OGDH(1), SDHA(4)	6613532	10	8	9	5	4	0	4	1	1	0	0.722	1.000	1.000
388	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), GOT1(2), ME1(1), ME2(1), ME3(1), PGK1(2), PKLR(2), RPIA(1), TKT(2), TPI1(1)	13838061	17	10	17	6	5	3	1	5	3	0	0.571	1.000	1.000
389	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6AP1(2), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), CCL5(1), CSK(1), F11R(1), GIT1(2), HBEGF(1), IKBKB(1), JAM2(4), JAM3(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(2), MAPK9(1), MET(10), NFKB1(1), NFKB2(2), NFKBIA(2), NOD1(1), PAK1(2), PLCG1(6), PLCG2(9), PTPN11(7), PTPRZ1(12), RAC1(1), RELA(1), TCIRG1(2), TJP1(5)	51857136	99	59	96	26	22	15	17	22	22	1	0.0605	1.000	1.000
390	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1L(1), GTF2A2(1), GTF2E1(3), GTF2F1(1), GTF2H1(1), GTF2H4(1), GTF2IRD1(3), STON1(2), TAF1(8), TAF10(1), TAF1L(6), TAF2(3), TAF4(3), TAF4B(3), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(2), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(1)	27646323	48	24	48	13	10	8	7	15	7	1	0.222	1.000	1.000
391	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	AKT1(1), APC(2), AR(4), ASAH1(1), BRAF(6), CCL16(1), DAG1(1), GNA11(1), GNA15(1), GNAI1(4), ITPR1(4), ITPR2(13), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), MAPK10(1), PHKA2(5), PIK3CD(3), PITX2(4), PTX3(2), RAF1(1)	36071505	75	43	74	23	18	7	22	19	7	2	0.271	1.000	1.000
392	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(3), ACADL(1), ACADM(2), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), AOX1(5), BCAT1(1), BCKDHA(1), BCKDHB(1), ECHS1(2), EHHADH(1), HADHA(2), HIBADH(1), MCCC1(2), MCCC2(5), MUT(1), OXCT1(1), PCCA(1), PCCB(3), SDS(1)	27614201	55	28	54	18	15	15	5	11	9	0	0.276	1.000	1.000
393	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), PTK2B(2), SHC1(1), SOS1(4)	6770830	8	6	8	4	1	2	0	3	2	0	0.730	1.000	1.000
394	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	CES1(1), ESCO1(1), ESCO2(2), LIPA(2), PLA1A(3), PNPLA3(1), SH3GLB1(3)	19436703	13	4	13	3	2	4	1	4	2	0	0.342	1.000	1.000
395	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(2), AKT1(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(4), MAPK1(2), MAPK3(1), PRKACG(1), PRKAR1A(2), PRKCA(5), RAC1(1), RPS6KA1(4), RPS6KA5(1), SOS1(4)	19449447	34	21	34	10	12	2	4	6	8	2	0.355	1.000	1.000
396	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(1), ARSD(3), ARSE(3), CYP11B1(1), CYP11B2(1), CYP19A1(1), HSD17B7(2), HSD17B8(1), HSD3B1(2), HSD3B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SRD5A1(1), SULT2A1(2), SULT2B1(2), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2), WBSCR22(2)	38494713	88	56	86	28	21	11	19	29	8	0	0.203	1.000	1.000
397	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), GOT1(2), ME1(1), ME3(1), PGK1(2), PKLR(2), RPIA(1), TKT(2), TKTL2(2), TPI1(1)	15473083	18	11	18	8	5	3	1	5	4	0	0.770	1.000	1.000
398	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ACADM(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CNDP1(2), DPYD(4), DPYS(4), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HIBCH(1), MLYCD(3), SMS(1), SRM(2)	20695116	43	19	42	15	14	6	4	11	8	0	0.415	1.000	1.000
399	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(2), ASAH1(1), CREB1(1), DAG1(1), EPHB2(2), FOS(1), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1)	21971132	22	14	22	7	5	4	5	4	4	0	0.332	1.000	1.000
400	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(2), EHHADH(1), ESCO1(1), ESCO2(2), GCDH(1), HADHA(2), PNPLA3(1), SH3GLB1(3)	19911387	22	11	21	8	7	5	3	4	3	0	0.497	1.000	1.000
401	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(1), APC(2), AXIN1(1), CCND1(4), CD14(1), CTNNB1(3), FZD1(2), GJA1(5), GNAI1(4), IRAK1(1), LBP(2), LEF1(1), NFKB1(1), PPP2CA(4), RELA(1), TLR4(2), TOLLIP(1)	20667826	36	24	36	12	11	5	7	8	5	0	0.394	1.000	1.000
402	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(1), EIF4A1(6), EIF4A2(2), EIF4E(2), EIF4G1(4), EIF4G2(1), EIF4G3(6), GHR(4), IRS1(4), MAPK1(2), MAPK3(1), MKNK1(2), PABPC1(4), PRKCA(5), RPS6KB1(2)	18060612	46	28	46	14	13	9	7	8	7	2	0.328	1.000	1.000
403	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), AOX1(5), DBH(3), DDC(3), ECH1(1), ESCO1(1), ESCO2(2), FAH(2), GOT1(2), GSTZ1(3), HGD(5), HPD(1), LCMT1(2), LCMT2(1), MAOA(2), METTL2B(3), METTL6(1), PNPLA3(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SH3GLB1(3), TAT(1), TH(3), TPO(6), TYR(4), TYRP1(4), WBSCR22(2)	45567111	94	45	93	28	27	14	12	28	13	0	0.141	1.000	1.000
404	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(5), PER2(3), PER3(1)	13091795	16	6	16	8	2	4	1	8	1	0	0.877	1.000	1.000
405	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), DDC(3), EPX(5), GOT1(2), HPD(1), LPO(5), MAOA(2), MPO(2), PRDX1(1), TAT(1), TPO(6)	16843561	38	22	38	13	17	8	4	6	2	1	0.199	1.000	1.000
406	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), BPNT1(1), ILK(1), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(3), PTK2B(2), RBL2(4), SHC1(1), SOS1(4)	13336249	22	14	22	9	4	4	1	10	2	1	0.668	1.000	1.000
407	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(8), ATR(6), BRCA1(2), CCNB1(2), CDC25A(1), CDC25B(1), CDC34(2), CDKN1A(1), CHEK1(3), CHEK2(3), EP300(5), MDM2(3), MYT1(7), PRKDC(11), RPS6KA1(4), WEE1(1), YWHAH(1), YWHAQ(1)	31368960	62	36	62	17	14	6	7	18	16	1	0.439	1.000	1.000
408	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(2), CCNB1(2), GNAI1(4), GNAS(4), MAPK1(2), MAPK3(1), MYT1(7), PRKACG(1), PRKAR1A(2), RPS6KA1(4)	15747333	29	24	29	10	7	0	4	5	12	1	0.715	1.000	1.000
409	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(2), FUCA2(3), GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(3), HYAL2(2), IDS(2), LCT(10), MAN2B1(2), MAN2B2(5), MAN2C1(2), MANBA(1), NAGLU(3), NEU1(1), NEU2(6), NEU3(2), SPAM1(3)	26414962	62	41	62	20	23	5	9	16	9	0	0.354	1.000	1.000
410	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), ACTN2(6), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(2), PTK2(2), RAC1(1), SPTAN1(5), TLN1(5)	21879415	28	12	28	9	9	3	6	6	4	0	0.409	1.000	1.000
411	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(4), E2F1(1), ETS1(4), ETV3(1), FOS(1), HDAC2(4), HDAC5(1), NCOR2(8), RBL1(4), RBL2(4), SIN3A(3), SIN3B(1)	19892806	36	18	36	13	7	5	5	9	10	0	0.599	1.000	1.000
412	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(1), DERA(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(3), PFKL(5), PFKP(1), PGD(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RBKS(1), RPIA(1), TALDO1(2), TKT(2), TKTL2(2)	18631102	33	21	33	12	14	7	0	4	8	0	0.314	1.000	1.000
413	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(1), BTK(3), CDKN2A(4), IARS(1), INPP5D(2), PDK1(2), PPP1R13B(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SOS1(4), SOS2(5), TEC(3), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	25270273	51	30	51	16	7	7	10	18	9	0	0.396	1.000	1.000
414	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(3), CYCS(2), DAXX(2), FAS(1), FASLG(1), MAPKAPK2(1), MAPKAPK3(1), TNF(1)	8694596	12	6	12	6	0	3	3	5	1	0	0.851	1.000	1.000
415	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(2), ASAH1(1), DAG1(1), DLG4(3), EPHB2(2), GNAI1(4), ITPR1(4), ITPR2(13), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), PITX2(4), PTX3(2), RAC1(1), RHO(1), RYR1(11)	35050698	70	39	70	22	19	8	17	16	9	1	0.235	1.000	1.000
416	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(8), BMPR1B(1), CDK4(1), CDKN1B(3), CEBPB(1), DMC1(2), EGR1(2), ESR2(3), FSHR(2), GJA4(1), MLH1(4), MSH5(2), NCOR1(9), NR5A1(1), NRIP1(2), PGR(4), PRLR(2), SMPD1(2), VDR(2), ZP2(4)	26914895	56	31	56	18	11	10	7	14	13	1	0.584	1.000	1.000
417	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CALR(2), CANX(1), CD4(1), CIITA(2), CREB1(1), CTSB(3), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AA1(2), HSP90AB1(1), IFI30(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), KIR2DL3(2), KIR3DL1(1), KIR3DL3(1), KLRC1(2), KLRC2(1), KLRC4(1), LGMN(1), NFYA(1), PSME1(3), RFX5(1), RFXANK(1), TAP1(1), TAPBP(1)	35456910	59	33	59	19	9	10	10	19	11	0	0.311	1.000	1.000
418	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(3), PPP3CA(1), PPP3CC(1), SLC2A4(1), SYT1(2), YWHAH(1)	15514595	25	9	25	9	6	7	4	2	6	0	0.430	1.000	1.000
419	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX5(2), CBR3(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2U1(1), CYP4A11(1), CYP4A22(2), CYP4F3(5), DHRS4(1), EPHX2(2), GGT1(2), GPX2(2), GPX6(1), LTA4H(4), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGES(1), PTGES2(1), PTGS1(2), PTGS2(2), TBXAS1(2)	29827462	66	47	66	21	18	10	8	16	14	0	0.277	1.000	1.000
420	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), DDC(3), EPX(5), ESCO1(1), ESCO2(2), GOT1(2), HPD(1), LPO(5), MAOA(2), MPO(2), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(6)	26253253	44	24	44	14	18	11	4	8	3	0	0.185	1.000	1.000
421	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ASPA(1), CNDP1(2), DDC(3), HAL(1), HARS(2), HDC(2), HNMT(1), MAOA(2), PRPS1(1), PRPS2(3)	18746239	34	21	34	13	16	5	4	7	2	0	0.446	1.000	1.000
422	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), ATF2(2), DLD(1), DUSP10(1), DUSP4(1), GCK(2), IL1R1(2), MAP2K5(2), MAP3K1(4), MAP3K10(1), MAP3K12(5), MAP3K13(3), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K9(3), MAPK10(1), MAPK7(5), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(3), NR2C2(2), PAPPA(4), SHC1(1), TRAF6(1), ZAK(2)	37997819	62	35	62	18	18	7	11	19	7	0	0.300	1.000	1.000
423	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(1), ARSD(3), ARSE(3), CYP11B1(1), CYP11B2(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(1), SULT2A1(2), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(5)	20969314	39	28	38	15	13	4	10	9	3	0	0.420	1.000	1.000
424	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IKBKB(1), IL1B(2), IL1R1(2), IL1RAP(1), IL6(1), IRAK1(1), IRAK2(2), IRAK3(6), MAP2K3(3), MAP3K1(4), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), TGFB2(2), TGFB3(1), TNF(1), TOLLIP(1), TRAF6(1)	22717523	36	21	36	12	9	7	6	9	5	0	0.373	1.000	1.000
425	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(2), DIAPH1(5), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(5), PTK2(2), RAF1(1), ROCK1(2), SHC1(1), TLN1(5)	25740474	34	18	34	11	10	1	8	9	5	1	0.357	1.000	1.000
426	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(3), EEF1A2(1), EEF1B2(1), EEF1D(3), EEF2(1), EEF2K(2), EIF2AK1(1), EIF2AK3(2), EIF2B4(1), EIF2S2(1), EIF4A1(6), EIF4A2(2), EIF4E(2), EIF4G1(4), EIF4G3(6), EIF5A(1), GSPT2(4), PABPC1(4), PABPC3(2), PAIP1(1), SLC35A4(1)	33443963	49	30	49	15	12	6	4	17	10	0	0.484	1.000	1.000
427	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(3), BAK1(2), BAX(1), BIRC2(2), CASP2(1), CASP8(2), CYCS(2), FAS(1), FASLG(1), GZMB(1), MAP3K1(4), MAPK10(1), MDM2(3), NFKB1(1), NFKBIA(2), PARP1(2), PRF1(3), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	28017297	42	32	42	15	13	7	5	11	6	0	0.489	1.000	1.000
428	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), ARG2(2), ASL(2), ASS1(3), CPS1(3), MAOA(2), ODC1(3), SMS(1), SRM(2)	22576141	33	18	33	12	12	4	2	7	8	0	0.574	1.000	1.000
429	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CLOCK(1), CRY1(2), DNAJA1(3), EIF4G2(1), ETV6(4), HERPUD1(1), HSPA8(3), IDI1(2), KLF9(2), MYF6(2), NCKAP1(4), NCOA4(3), NR1D2(1), PER1(5), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), UGP2(1), ZFR(1)	28077396	46	22	46	15	7	9	7	19	4	0	0.545	1.000	1.000
430	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(7), ATP4A(5), ATP4B(2), ATP5B(2), ATP5G2(1), ATP6AP1(2), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), COX10(3), COX15(1), COX17(1), COX6B1(1), COX7A1(1), COX7B2(1), NDUFA10(3), NDUFA3(1), NDUFA7(1), NDUFA9(3), NDUFB11(1), NDUFB5(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), SDHA(4), SDHC(2), TCIRG1(2), UQCRC1(3), UQCRC2(1), UQCRH(2)	42556271	72	36	71	22	15	12	12	19	13	1	0.249	1.000	1.000
431	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), CREB1(1), EP300(5), EPO(1), LDHA(1), NOS3(7)	13022463	19	11	19	8	8	1	2	7	1	0	0.694	1.000	1.000
432	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(1), IL4R(2), IRS1(4), IRS2(1), JAK1(1), JAK3(3), MAP4K1(1), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(3), PPP1R13B(2), RAF1(1), SHC1(1), SOS1(4), SOS2(5), STAT6(4)	25062406	38	23	38	13	7	6	3	14	7	1	0.496	1.000	1.000
433	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	CRKL(1), DOCK1(1), ELK1(3), FOS(1), HGF(3), ITGA1(2), ITGB1(2), MAP2K2(1), MAP4K1(1), MAPK1(2), MAPK3(1), MAPK8(2), MET(10), PAK1(2), PTK2(2), PTK2B(2), PTPN11(7), RAF1(1), RASA1(4), SOS1(4), STAT3(2)	30242672	54	32	52	19	12	7	7	15	12	1	0.409	1.000	1.000
434	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(2), AXIN1(1), CREBBP(9), CTNNB1(3), EP300(5), FZD1(2), LDB1(2), LEF1(1), PITX2(4), TRRAP(13)	25438161	42	23	42	16	14	4	6	12	6	0	0.602	1.000	1.000
435	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	DAXX(2), EGF(7), ETS1(4), FOS(1), HOXA7(2), IKBKB(1), MAP2K3(3), MAP3K1(4), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKBIA(2), PPP2CA(4), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), RAF1(1), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRAF2(2)	35608485	62	37	62	22	20	12	8	9	10	3	0.217	1.000	1.000
436	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(2), AXIN1(1), CCND1(4), CSNK1E(1), CTNNB1(3), DVL2(1), DVL3(2), FZD1(2), FZD10(2), FZD2(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), MAPK10(1), MAPK9(1), PAFAH1B1(4), PPP2R5C(1), PPP2R5E(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), RAC1(1), SFRP4(1), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT5B(1), WNT7A(2)	46081692	67	41	67	23	25	5	10	12	13	2	0.284	1.000	1.000
437	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(1), BCR(3), BLNK(2), BTK(3), CD19(1), CSK(1), DAG1(1), EPHB2(2), MAP2K2(1), MAPK1(2), NFAT5(4), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PI3(2), PIK3CD(3), PLCG2(9), PPP1R13B(2), RAF1(1), SERPINA4(2), SHC1(1), SOS1(4), SOS2(5), VAV1(5)	37472639	61	36	61	21	23	10	6	15	7	0	0.241	1.000	1.000
438	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(3), ARHGDIB(1), BAG4(1), BIRC2(2), CASP2(1), CASP8(2), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(2), GSN(1), LMNA(2), LMNB2(2), MAP3K1(4), MAP3K5(3), MAPK8(2), MDM2(3), NFKB1(1), NFKBIA(2), NUMA1(8), PAK2(2), PRKDC(11), PTK2(2), RASA1(4), RB1(7), RELA(1), RIPK1(3), SPTAN1(5), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	52916612	89	54	89	27	22	14	15	23	14	1	0.264	1.000	1.000
439	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(5), CANT1(4), CDA(1), CTPS2(2), DCK(1), DCTD(1), DHODH(2), DPYD(4), DPYS(4), ENTPD1(3), NT5C(3), NT5E(1), NT5M(1), POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1), RRM1(3), TK2(3), UCK1(3), UMPS(1), UPP1(1)	43920305	81	45	80	27	20	15	8	27	11	0	0.457	1.000	1.000
440	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(2), ACTG1(2), ACTN1(1), ACTN2(6), ACTN4(2), AKT1(1), ARHGAP5(2), BCAR1(3), BIRC2(2), BRAF(6), CCND1(4), CHAD(1), COL11A1(6), COL11A2(4), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(5), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), COMP(1), CRKL(1), CTNNB1(3), DIAPH1(5), DOCK1(1), EGF(7), ELK1(3), ERBB2(2), FARP2(2), FLNA(13), FLNB(9), FLNC(12), FLT1(5), FN1(6), FYN(1), HGF(3), IBSP(1), IGF1(1), IGF1R(7), ILK(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), KDR(6), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MET(10), MYL2(2), MYL5(1), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PARVA(1), PARVB(2), PDGFA(1), PDGFC(2), PDGFD(2), PDGFRB(1), PGF(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PRKCA(5), PRKCG(2), PTK2(2), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(4), RELN(13), ROCK1(2), ROCK2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), SPP1(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TLN1(5), TLN2(7), TNC(8), TNN(6), TNR(5), TNXB(11), VAV1(5), VAV2(2), VAV3(2), VCL(1), VEGFA(2), VEGFB(2), VEGFC(2), VWF(7)	276986969	525	222	521	169	161	96	68	125	69	6	0.00437	1.000	1.000
441	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(4), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRA2C(1), ADRB2(1), AGTR2(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), C5AR1(1), CALCR(1), CCKBR(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CNR1(1), CNR2(2), CRHR2(3), CTSG(2), CYSLTR1(3), CYSLTR2(2), DRD3(2), DRD5(3), EDNRA(1), EDNRB(1), F2(3), F2R(2), F2RL1(4), F2RL3(1), FPR1(1), FSHR(2), GABBR1(2), GABBR2(1), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4), GABRB1(5), GABRB2(4), GABRB3(1), GABRD(4), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(2), GABRP(3), GABRQ(1), GABRR1(3), GALR1(1), GH1(1), GH2(2), GHR(4), GHRHR(2), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(4), GNRHR(2), GPR156(1), GPR35(1), GPR50(3), GPR63(1), GPR83(2), GRIA1(5), GRIA2(2), GRIA3(6), GRIA4(4), GRID1(2), GRID2(3), GRIK1(4), GRIK2(3), GRIK3(2), GRIK4(5), GRIK5(3), GRIN1(2), GRIN2A(8), GRIN2B(7), GRIN2C(4), GRIN2D(4), GRIN3A(3), GRIN3B(1), GRM1(4), GRM2(4), GRM3(7), GRM4(4), GRM5(4), GRM6(3), GRM7(3), GRM8(2), GRPR(3), GZMA(1), HCRTR2(2), HRH1(3), HRH4(2), HTR1A(1), HTR1B(2), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LEPR(2), LTB4R(1), LTB4R2(1), MC1R(3), MC3R(2), MC4R(3), MC5R(3), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(2), MTNR1B(1), NMBR(5), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(2), NPY1R(3), NPY2R(1), NR3C1(3), NTSR1(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY13(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(3), PARD3(2), PRL(1), PRLR(2), PRSS1(1), PRSS3(2), PTAFR(1), PTGER3(2), PTGER4(1), PTGFR(6), PTH2R(2), RXFP1(2), RXFP2(5), SCTR(1), SSTR2(3), SSTR3(5), SSTR4(8), TAAR1(1), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR2(2), TACR3(3), TBXA2R(1), THRA(2), THRB(2), TRHR(2), TRPV1(2), TSHR(4), UTS2R(1), VIPR1(1), VIPR2(1)	170192910	432	193	429	138	148	76	51	111	46	0	0.00169	1.000	1.000
442	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), ACTG1(2), CHAD(1), COL11A1(6), COL11A2(4), COL17A1(2), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(5), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), COMP(1), DSC1(3), DSC2(2), DSC3(6), DSG1(6), DSG2(8), DSG3(2), DSG4(2), FN1(6), GJA1(5), GJA10(1), GJA3(1), GJA4(1), GJA8(1), GJB2(1), GJB4(1), GJB6(2), GJC3(1), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(5), KRT1(3), KRT12(1), KRT13(3), KRT14(1), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT2(2), KRT20(3), KRT23(1), KRT24(2), KRT25(2), KRT27(2), KRT28(5), KRT3(4), KRT31(3), KRT33A(5), KRT33B(2), KRT34(2), KRT35(3), KRT36(4), KRT37(3), KRT39(2), KRT40(1), KRT5(4), KRT6A(2), KRT6B(4), KRT6C(3), KRT7(1), KRT71(4), KRT73(5), KRT75(4), KRT76(1), KRT77(1), KRT78(2), KRT79(3), KRT8(4), KRT81(3), KRT82(2), KRT83(4), KRT84(3), KRT86(3), KRT9(1), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), LMNA(2), LMNB2(2), NES(2), PRPH(1), RELN(13), SPP1(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNC(8), TNN(6), TNR(5), TNXB(11), VIM(3), VWF(7)	190061164	409	186	404	149	148	94	36	91	38	2	0.0761	1.000	1.000
443	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	241	ACVR1B(4), ACVR1C(1), AKT1(1), ARRB1(2), ARRB2(2), ATF2(2), ATF4(1), BDNF(1), BRAF(6), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1F(6), CACNA1G(7), CACNA1H(7), CACNA1I(6), CACNA1S(7), CACNA2D1(6), CACNA2D2(2), CACNA2D3(2), CACNA2D4(2), CACNB2(3), CACNB3(2), CACNB4(2), CACNG1(2), CACNG2(1), CACNG7(3), CACNG8(1), CD14(1), CDC25B(1), CRKL(1), DAXX(2), DDIT3(2), DUSP1(1), DUSP10(1), DUSP14(1), DUSP16(3), DUSP4(1), DUSP5(3), DUSP7(1), DUSP9(2), ECSIT(1), EGF(7), ELK1(3), ELK4(1), FAS(1), FASLG(1), FGF13(2), FGF14(1), FGF16(1), FGF23(1), FGF4(1), FGF5(3), FGF6(1), FGF7(1), FGFR1(2), FGFR2(3), FGFR3(2), FGFR4(3), FLNA(13), FLNB(9), FLNC(12), FOS(1), GNG12(1), IKBKB(1), IL1B(2), IL1R1(2), IL1R2(3), KRAS(3), MAP2K2(1), MAP2K3(3), MAP2K5(2), MAP3K1(4), MAP3K10(1), MAP3K12(5), MAP3K13(3), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K8(4), MAP4K1(1), MAP4K3(2), MAP4K4(2), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(5), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MKNK1(2), MRAS(1), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(2), NLK(1), NR4A1(1), NTF3(1), NTRK1(2), PAK1(2), PAK2(2), PDGFA(1), PDGFRB(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), PTPN5(1), PTPN7(2), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(4), RASA1(4), RASA2(3), RASGRF1(4), RASGRF2(4), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA5(1), RPS6KA6(3), RRAS(1), SOS1(4), SOS2(5), SRF(2), STK3(2), STMN1(1), TAOK1(2), TAOK2(4), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNF(1), TRAF2(2), TRAF6(1), ZAK(2)	209435931	414	185	411	148	126	66	52	91	75	4	0.168	1.000	1.000
444	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	165	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY7(2), ADCY8(1), ADCY9(7), ADRA1A(2), ADRA1B(2), ADRB2(1), ATP2A1(1), ATP2A2(4), ATP2A3(2), ATP2B2(5), ATP2B3(6), AVPR1A(4), AVPR1B(1), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1F(6), CACNA1G(7), CACNA1H(7), CACNA1I(6), CACNA1S(7), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CCKBR(2), CHRM1(2), CHRM3(3), CHRM5(4), CHRNA7(1), CYSLTR1(3), CYSLTR2(2), EDNRA(1), EDNRB(1), ERBB2(2), ERBB3(4), ERBB4(5), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(4), GRIN1(2), GRIN2A(8), GRIN2C(4), GRIN2D(4), GRM1(4), GRM5(4), GRPR(3), HRH1(3), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), ITPR1(4), ITPR2(13), ITPR3(13), LTB4R2(1), MYLK(5), MYLK2(1), NOS1(6), NOS3(7), NTSR1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRB(1), PHKA1(3), PHKA2(5), PHKB(1), PHKG1(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(5), PPID(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), PTAFR(1), PTGER3(2), PTGFR(6), PTK2B(2), RYR1(11), RYR3(12), SLC25A4(1), SLC25A5(4), SLC25A6(1), SLC8A1(3), SLC8A2(3), SLC8A3(2), TACR2(2), TACR3(3), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(3)	195952004	405	184	403	153	147	67	49	82	57	3	0.160	1.000	1.000
445	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(2), ACTN1(1), ACTN2(6), ACTN4(2), APC(2), ARAF(1), ARHGEF1(1), ARHGEF12(3), ARHGEF4(4), ARHGEF6(5), ARPC1A(1), ARPC1B(2), ARPC3(1), BAIAP2(3), BCAR1(3), BRAF(6), CD14(1), CFL1(1), CFL2(1), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CRKL(1), CSK(1), CYFIP2(4), DIAPH1(5), DIAPH2(2), DIAPH3(2), DOCK1(1), EGF(7), F2(3), F2R(2), FGD1(1), FGD3(2), FGF13(2), FGF14(1), FGF16(1), FGF23(1), FGF4(1), FGF5(3), FGF6(1), FGF7(1), FGFR1(2), FGFR2(3), FGFR3(2), FGFR4(3), FN1(6), GIT1(2), GNA13(2), GNG12(1), GSN(1), IQGAP1(9), IQGAP2(5), IQGAP3(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAD(3), ITGAE(6), ITGAL(2), ITGAM(2), ITGAV(3), ITGAX(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), KRAS(3), LIMK1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MRAS(1), MSN(1), MYH10(7), MYH14(4), MYL2(2), MYL5(1), MYLK(5), MYLK2(1), NCKAP1(4), NCKAP1L(3), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PDGFA(1), PDGFRB(1), PFN4(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PTK2(2), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(4), RRAS(1), SCIN(2), SOS1(4), SOS2(5), SSH1(2), SSH2(1), SSH3(2), TIAM1(5), TIAM2(9), VAV1(5), VAV2(2), VAV3(2), VCL(1), WAS(2), WASF1(1), WASF2(1), WASL(2)	204712747	350	162	349	125	90	54	51	95	57	3	0.236	1.000	1.000
446	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(4), ABLIM1(4), ABLIM2(2), ABLIM3(5), ARHGEF12(3), CFL1(1), CFL2(1), CXCR4(2), DCC(6), DPYSL5(1), EFNA1(1), EFNA3(3), EFNA5(1), EFNB1(2), EFNB2(1), EFNB3(1), EPHA2(2), EPHA3(7), EPHA4(7), EPHA5(5), EPHA6(2), EPHA7(5), EPHA8(5), EPHB1(2), EPHB2(2), EPHB3(1), EPHB4(4), EPHB6(6), FES(5), FYN(1), GNAI1(4), GNAI2(1), GNAI3(2), ITGB1(2), KRAS(3), L1CAM(7), LIMK1(4), LRRC4C(4), MAPK1(2), MAPK3(1), MET(10), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NGEF(6), NRP1(4), NTN1(1), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PLXNA1(10), PLXNA2(6), PLXNA3(6), PLXNB1(6), PLXNB2(4), PLXNB3(8), PLXNC1(2), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RASA1(4), RGS3(9), RHOD(1), RND1(1), ROBO1(4), ROBO2(9), ROBO3(5), ROCK1(2), ROCK2(4), SEMA3A(5), SEMA3C(1), SEMA3D(3), SEMA3E(6), SEMA3F(2), SEMA4A(2), SEMA4B(1), SEMA4D(2), SEMA4F(3), SEMA4G(3), SEMA5B(1), SEMA6A(3), SEMA6B(4), SEMA6C(2), SEMA6D(5), SEMA7A(3), SLIT1(7), SLIT2(5), SLIT3(3), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(2), UNC5C(2), UNC5D(1)	150409358	339	152	337	104	100	54	48	86	50	1	0.0146	1.000	1.000
447	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(2), ACTG1(2), ACTN1(1), ACTN2(6), ACTN4(2), AKT1(1), AMOTL1(4), ASH1L(5), CASK(2), CDK4(1), CGN(1), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(2), CSNK2B(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTTN(1), EPB41L1(2), EPB41L2(7), EPB41L3(7), EXOC3(1), EXOC4(3), F11R(1), GNAI1(4), GNAI2(1), GNAI3(2), HCLS1(1), INADL(6), JAM2(4), JAM3(2), KRAS(3), LLGL1(3), LLGL2(3), MAGI1(4), MAGI2(4), MAGI3(6), MLLT4(7), MPDZ(10), MRAS(1), MYH1(12), MYH10(7), MYH11(10), MYH13(11), MYH14(4), MYH15(7), MYH3(9), MYH6(5), MYH7(11), MYH7B(9), MYL2(2), MYL5(1), OCLN(2), PARD3(2), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PPP2R3A(3), PPP2R4(1), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), RAB3B(1), RRAS(1), SPTAN1(5), SYMPK(3), TJAP1(1), TJP1(5), TJP2(2), TJP3(3), YES1(2), ZAK(2)	138474372	289	146	288	90	102	41	39	69	36	2	0.0413	1.000	1.000
448	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(4), CD44(3), CHAD(1), COL11A1(6), COL11A2(4), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(5), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), DAG1(1), FN1(6), FNDC1(4), FNDC3A(5), FNDC5(1), GP5(2), GP9(1), HMMR(1), HSPG2(17), IBSP(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), RELN(13), SDC1(1), SDC3(1), SPP1(2), SV2A(2), SV2B(3), SV2C(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNC(8), TNN(6), TNR(5), TNXB(11), VWF(7)	171246464	327	143	325	105	104	77	36	71	37	2	0.0126	1.000	1.000
449	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	246	ACVR1(3), ACVR1B(4), ACVR2A(2), AMHR2(1), BMPR1A(1), BMPR1B(1), CCL1(1), CCL11(2), CCL16(1), CCL20(2), CCL26(2), CCL27(1), CCL5(1), CCR2(2), CCR3(1), CCR4(2), CCR6(2), CCR7(1), CCR8(1), CCR9(2), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(3), CSF1R(4), CSF2RB(2), CSF3R(2), CX3CL1(1), CX3CR1(1), CXCL13(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(1), EDAR(6), EGF(7), EPO(1), EPOR(1), FAS(1), FASLG(1), FLT1(5), FLT3(4), FLT4(6), GDF5(1), GH1(1), GH2(2), GHR(4), HGF(3), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(2), IL10(1), IL10RB(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA1(3), IL15(2), IL17A(1), IL17B(1), IL17RA(1), IL17RB(1), IL18(3), IL18R1(2), IL18RAP(3), IL19(1), IL1B(2), IL1R1(2), IL1R2(3), IL1RAP(1), IL20RA(2), IL21R(1), IL22RA1(1), IL23A(1), IL23R(5), IL26(1), IL2RB(2), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(3), IL7R(2), IL9(1), IL9R(2), INHBA(1), INHBB(1), INHBE(2), KDR(6), KIT(6), KITLG(2), LEPR(2), LIFR(2), LTB(1), LTBR(3), MET(10), MPL(2), NGFR(1), OSMR(3), PDGFC(2), PDGFRB(1), PLEKHO2(1), PPBP(1), PRL(1), PRLR(2), RELT(3), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF19(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(1), TNFRSF6B(1), TNFRSF8(2), TNFRSF9(3), TNFSF13B(1), TNFSF15(3), TNFSF8(2), TNFSF9(2), TPO(6), VEGFA(2), VEGFB(2), VEGFC(2), XCL1(1)	130956489	288	141	286	108	69	55	52	72	40	0	0.281	1.000	1.000
450	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(2), ATP1B1(1), ATP1B2(1), ATP2A2(4), ATP2A3(2), ATP2B2(5), ATP2B3(6), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1S(7), CACNB3(2), CALM3(1), CALR(2), CAMK1(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CASQ1(2), CASQ2(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), GJA1(5), GJA4(1), GJB2(1), GJB4(1), GJB6(2), GNA11(1), GNAI2(1), GNAI3(2), GNAO1(2), GNAZ(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GRK4(5), GRK5(4), ITPR1(4), ITPR2(13), ITPR3(13), KCNB1(3), KCNJ3(1), KCNJ5(3), MIB1(1), MYCBP(1), PEA15(1), PLCB3(4), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(9), RGS4(2), RGS6(2), RGS7(3), RGS9(2), RYR1(11), RYR3(12), SFN(2), SLC8A1(3), SLC8A3(2), USP5(1), YWHAB(2), YWHAH(1), YWHAQ(1)	136891849	265	119	264	103	93	42	36	49	42	3	0.359	1.000	1.000
451	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(2), CADM1(3), CD22(3), CD226(1), CD274(1), CD276(1), CD28(1), CD4(1), CD40(1), CD40LG(2), CD58(1), CD86(1), CDH1(4), CDH15(1), CDH2(2), CDH3(3), CDH4(6), CDH5(2), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(2), CNTN2(2), CNTNAP1(4), CNTNAP2(4), CTLA4(1), ESAM(1), F11R(1), GLG1(2), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), ICAM1(2), ICAM2(1), ICOS(1), ICOSLG(2), ITGA4(5), ITGA6(3), ITGA8(5), ITGAL(2), ITGAM(2), ITGAV(3), ITGB1(2), ITGB2(1), ITGB7(4), ITGB8(1), JAM2(4), JAM3(2), L1CAM(7), MAG(2), MPZ(1), NCAM1(2), NEGR1(3), NEO1(8), NFASC(1), NLGN1(3), NLGN2(4), NLGN3(4), NRCAM(5), NRXN1(5), NRXN3(5), OCLN(2), PDCD1LG2(1), PTPRC(7), PTPRF(5), PTPRM(7), PVR(2), PVRL1(1), PVRL3(2), SDC1(1), SDC3(1), SELE(6), SELP(2), SELPLG(1), SIGLEC1(4), SPN(1), VCAM1(1), VCAN(8)	113198311	227	114	225	91	63	47	23	55	39	0	0.472	1.000	1.000
452	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA2(2), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ARRB1(2), ARRB2(2), ATF1(1), ATF2(2), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(2), CACNB3(2), CALM3(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CNN2(2), CORIN(3), DGKZ(2), FOS(1), GABPA(2), GBA2(1), GJA1(5), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GRK4(5), GRK5(4), GUCY1A3(2), IGFBP2(1), IGFBP6(1), IL1B(2), IL6(1), ITPR1(4), ITPR2(13), ITPR3(13), MIB1(1), MYL2(2), MYLK2(1), NFKB1(1), NOS1(6), NOS3(7), PDE4B(1), PDE4D(6), PLCB3(4), PLCD1(1), PLCG1(6), PLCG2(9), PRKAR1A(2), PRKCA(5), PRKCH(3), PRKCQ(2), RAMP3(1), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(9), RGS4(2), RGS6(2), RGS7(3), RGS9(2), RLN1(1), RYR1(11), RYR3(12), SFN(2), SLC8A1(3), TNXB(11), USP5(1), YWHAB(2), YWHAH(1), YWHAQ(1)	125794868	244	114	242	98	82	36	34	53	36	3	0.515	1.000	1.000
453	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ADK(1), ADSL(4), ADSSL1(1), AK5(2), AK7(4), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(1), ATIC(1), CANT1(4), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), GART(4), GDA(1), GMPR(1), GMPR2(2), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HPRT1(1), IMPDH1(4), NPR1(1), NPR2(3), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1), PAICS(2), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE2A(4), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE5A(1), PDE7A(2), PDE7B(2), PDE8A(6), PDE8B(1), PDE9A(2), PFAS(6), PKLR(2), POLA1(2), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(1), PRIM2(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RRM1(3), RRM2B(1), XDH(8)	125158779	225	113	224	80	66	40	26	58	35	0	0.269	1.000	1.000
454	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA2(2), ACTN2(6), ACTN4(2), DMD(13), MYBPC1(4), MYBPC2(4), MYH3(9), MYH6(5), MYH7(11), MYL1(2), MYL2(2), MYOM1(3), NEB(20), TNNI1(1), TNNT1(1), TNNT3(4), TPM1(6), TPM2(1), TPM3(2), TPM4(1), TTN(120), VIM(3)	101273842	222	109	221	70	66	39	27	68	20	2	0.153	1.000	1.000
455	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(1), ADRB2(1), AGTR2(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), CCKBR(2), CCR10(1), CCR2(2), CCR3(1), CCR4(2), CCR6(2), CCR7(1), CCR8(1), CCR9(2), CHML(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(2), DRD3(2), DRD5(3), EDNRA(1), EDNRB(1), F2R(2), F2RL1(4), F2RL3(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(2), GPR17(1), GPR173(1), GPR174(1), GPR35(1), GPR37(3), GPR37L1(1), GPR4(1), GPR50(3), GPR6(2), GPR63(1), GPR83(2), GPR85(2), GPR87(1), GRPR(3), HCRTR2(2), HRH1(3), HTR1A(1), HTR1B(2), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LTB4R(1), MC1R(3), MC3R(2), MC4R(3), MC5R(3), MLNR(1), MTNR1A(2), MTNR1B(1), NMBR(5), NMUR1(3), NMUR2(2), NPY1R(3), NPY2R(1), NTSR1(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR5V1(3), OR7C1(1), P2RY1(1), P2RY12(2), P2RY13(1), P2RY2(2), P2RY6(2), PTAFR(1), PTGER4(1), PTGFR(6), RHO(1), RRH(1), SSTR2(3), SSTR3(5), SSTR4(8), SUCNR1(2), TBXA2R(1), TRHR(2)	93357731	215	108	214	81	79	33	33	54	16	0	0.0967	1.000	1.000
456	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(6), AMY2B(3), ASCC3(3), ATP13A2(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(2), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(3), DHX58(1), ENPP1(4), ENPP3(2), ENTPD7(2), EP400(3), ERCC2(3), ERCC3(2), G6PC(7), G6PC2(1), GAA(5), GANC(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(3), HK3(3), IFIH1(4), LYZL1(1), MGAM(8), MOV10L1(3), PGM3(1), PYGB(1), PYGL(5), PYGM(1), RAD54B(3), RAD54L(5), RUVBL2(2), SETX(4), SI(10), SKIV2L2(3), SMARCA2(2), SMARCA5(2), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2), UXS1(2)	94842560	199	107	198	48	61	33	26	53	26	0	0.00353	1.000	1.000
457	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(12), ACACB(11), AKT1(1), ARAF(1), BRAF(6), CALM3(1), CALML3(1), CALML6(1), CBL(1), CBLB(2), CBLC(2), CRKL(1), ELK1(3), EXOC7(1), FASN(3), FBP1(1), FBP2(1), FLOT2(3), G6PC(7), G6PC2(1), GCK(2), GYS1(1), GYS2(2), IKBKB(1), INPP5D(2), INSR(4), IRS1(4), IRS2(1), IRS4(6), KRAS(3), LIPE(4), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MKNK1(2), PCK1(3), PDE3A(2), PFKL(5), PFKP(1), PHKA1(3), PHKA2(5), PHKB(1), PHKG1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PKLR(2), PPARGC1A(1), PPP1CA(1), PPP1CB(1), PPP1R3A(6), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(2), PRKCI(2), PTPN1(1), PTPRF(5), PYGB(1), PYGL(5), PYGM(1), RAF1(1), RAPGEF1(4), RPS6KB1(2), RPS6KB2(3), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SLC2A4(1), SOCS4(2), SORBS1(1), SOS1(4), SOS2(5), SREBF1(6), TSC1(2), TSC2(3)	119655786	212	106	211	76	60	34	26	58	31	3	0.294	1.000	1.000
458	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(2), AXIN1(1), AXIN2(1), BTRC(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CCND1(4), CHD8(2), CREBBP(9), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CSNK2B(1), CTBP1(5), CTBP2(1), CTNNB1(3), CUL1(1), CXXC4(1), DAAM1(1), DAAM2(2), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(2), EP300(5), FZD1(2), FZD10(2), FZD2(1), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), LEF1(1), LRP5(7), LRP6(7), MAPK10(1), MAPK8(2), MAPK9(1), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NKD1(1), NLK(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PORCN(5), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PRICKLE1(2), PRICKLE2(4), PRKACG(1), PRKCA(5), PRKCG(2), RAC1(1), RAC2(1), RBX1(1), ROCK1(2), ROCK2(4), RUVBL1(1), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(3), SOX17(3), TBL1XR1(3), TBL1Y(1), TCF7L2(4), VANGL1(1), VANGL2(2), WIF1(3), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1)	123081781	223	104	223	72	71	32	27	56	36	1	0.126	1.000	1.000
459	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	147	AKT1(1), CBL(1), CBLB(2), CBLC(2), CCND1(4), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(9), CRLF2(3), CSF2RB(2), CSF3R(2), EP300(5), EPO(1), EPOR(1), GH1(1), GH2(2), GHR(4), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(2), IL10(1), IL10RB(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA1(3), IL15(2), IL19(1), IL20RA(2), IL21R(1), IL22RA1(1), IL23A(1), IL23R(5), IL26(1), IL2RB(2), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(3), IL7R(2), IL9(1), IL9R(2), IRF9(3), JAK1(1), JAK2(4), JAK3(3), LEPR(2), LIFR(2), MPL(2), OSMR(3), PIAS1(1), PIAS3(2), PIAS4(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIM1(2), PRL(1), PRLR(2), PTPN11(7), SOCS4(2), SOCS5(2), SOS1(4), SOS2(5), SPRED1(1), SPRED2(3), SPRY1(1), SPRY2(3), SPRY3(1), SPRY4(3), STAM(2), STAM2(1), STAT1(2), STAT2(1), STAT3(2), STAT4(2), STAT5A(1), STAT5B(2), STAT6(4), TPO(6), TYK2(7)	107722896	212	104	210	64	46	30	35	74	26	1	0.106	1.000	1.000
460	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(1), BRAF(6), CACNA1A(3), GNA11(1), GNA13(2), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), GNAZ(1), GRIA1(5), GRIA2(2), GRIA3(6), GRID2(3), GRM1(4), GRM5(4), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), IGF1(1), IGF1R(7), ITPR1(4), ITPR2(13), ITPR3(13), KRAS(3), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(6), NOS3(7), NPR1(1), NPR2(3), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PRKCA(5), PRKCG(2), PRKG1(1), PRKG2(1), RAF1(1), RYR1(11)	84162250	185	104	184	55	45	26	35	45	31	3	0.0777	1.000	1.000
461	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), CSNK1D(1), EGF(7), GJA1(5), GNA11(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAS(4), GRM1(4), GRM5(4), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HTR2A(1), HTR2B(2), HTR2C(3), ITPR1(4), ITPR2(13), ITPR3(13), KRAS(3), MAP2K2(1), MAP2K5(2), MAPK1(2), MAPK3(1), MAPK7(5), NPR1(1), NPR2(3), PDGFA(1), PDGFC(2), PDGFD(2), PDGFRB(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PRKACG(1), PRKCA(5), PRKCG(2), PRKG1(1), PRKG2(1), RAF1(1), SOS1(4), SOS2(5), TJP1(5), TUBA1A(3), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3)	97473371	185	102	185	70	63	24	26	39	30	3	0.449	1.000	1.000
462	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(4), ANAPC1(2), ANAPC10(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), ATM(8), ATR(6), BUB1(4), BUB1B(2), BUB3(3), CCNA1(2), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(4), CCNE1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(5), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC27(4), CDC6(1), CDC7(2), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), CHEK1(3), CHEK2(3), CREBBP(9), CUL1(1), DBF4(5), E2F1(1), E2F2(1), E2F3(1), EP300(5), ESPL1(6), FZR1(3), HDAC2(4), MCM2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(11), RB1(7), RBL1(4), RBL2(4), RBX1(1), SFN(2), SKP2(2), SMAD2(3), SMAD3(3), SMC1A(5), SMC1B(7), TGFB2(2), TGFB3(1), WEE1(1), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	103440163	210	100	210	56	35	37	37	56	42	3	0.0547	1.000	1.000
463	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALM3(1), CALML3(1), CALML6(1), CDS2(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), INPP4A(1), INPP4B(4), INPP5B(3), INPP5D(2), INPPL1(5), ITPK1(3), ITPR1(4), ITPR2(13), ITPR3(13), OCRL(5), PI4KA(7), PI4KB(2), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3C3(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(5), PRKCA(5), PRKCG(2), PTPMT1(1), SYNJ1(6), SYNJ2(8)	91958173	181	96	180	60	56	32	23	43	25	2	0.181	1.000	1.000
464	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(6), C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C3AR1(3), C4BPA(6), C4BPB(1), C5(6), C5AR1(1), C6(3), C7(5), C8A(2), C8B(4), CD46(3), CD55(1), CFB(1), CFD(1), CFH(8), CPB2(1), CR1(5), CR2(5), F10(1), F12(1), F13A1(2), F13B(4), F2(3), F2R(2), F5(7), F7(2), F8(20), F9(3), FGA(6), FGB(1), FGG(1), KLKB1(5), KNG1(2), MASP1(2), MBL2(3), PLAT(1), PLG(4), PROS1(1), SERPINA5(1), SERPINC1(1), SERPIND1(2), SERPINE1(2), SERPINF2(1), SERPING1(3), VWF(7)	69351045	175	96	175	52	54	30	21	47	23	0	0.0348	1.000	1.000
465	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(1), BRAF(6), CD244(1), FAS(1), FASLG(1), FCGR3A(1), FYN(1), GZMB(1), HLA-A(1), HLA-C(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL3(2), KIR3DL1(1), KLRC1(2), KLRC2(1), KRAS(3), LAT(2), LCK(1), LCP2(1), MAP2K2(1), MAPK1(2), MAPK3(1), MICA(4), MICB(1), NCR1(1), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PAK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PPP3CA(1), PPP3CC(1), PRF1(3), PRKCA(5), PRKCG(2), PTK2B(2), PTPN11(7), RAC1(1), RAC2(1), RAF1(1), SH2D1A(2), SH2D1B(1), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), ULBP3(5), VAV1(5), VAV2(2), VAV3(2), ZAP70(5)	83743298	170	96	166	56	41	27	20	51	28	3	0.144	1.000	1.000
466	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(1), ACTN2(6), ACTN4(2), ARHGAP5(2), BCAR1(3), CDH5(2), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTNND1(1), CXCR4(2), CYBA(1), CYBB(1), ESAM(1), F11R(1), GNAI1(4), GNAI2(1), GNAI3(2), ICAM1(2), ITGA4(5), ITGAL(2), ITGAM(2), ITGB1(2), ITGB2(1), ITK(1), JAM2(4), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(7), MMP9(2), MSN(1), MYL2(2), MYL5(1), NCF1(2), NCF2(3), NCF4(1), NOX1(1), NOX3(1), OCLN(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PRKCA(5), PRKCG(2), PTK2(2), PTK2B(2), PTPN11(7), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), RHOH(1), ROCK1(2), ROCK2(4), SIPA1(2), TXK(2), VAV1(5), VAV2(2), VAV3(2), VCAM1(1), VCL(1)	92367794	172	94	169	76	54	26	23	43	24	2	0.768	1.000	1.000
467	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ASIP(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3L1(1), CREB3L2(1), CREBBP(9), CTNNB1(3), DVL2(1), DVL3(2), EDNRB(1), EP300(5), FZD1(2), FZD10(2), FZD2(1), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), KIT(6), KITLG(2), KRAS(3), LEF1(1), MAP2K2(1), MAPK1(2), MAPK3(1), MC1R(3), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PRKACG(1), PRKCA(5), PRKCG(2), RAF1(1), TCF7L2(4), TYR(4), TYRP1(4), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1)	83365310	159	94	158	56	57	12	20	37	31	2	0.360	1.000	1.000
468	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTB(2), ACTG1(2), ACTN1(1), ACTN2(6), ACTN4(2), ACVR1B(4), ACVR1C(1), BAIAP2(3), CDH1(4), CREBBP(9), CSNK2A1(2), CSNK2B(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTNND1(1), EP300(5), ERBB2(2), FARP2(2), FER(1), FGFR1(2), FYN(1), IGF1R(7), INSR(4), IQGAP1(9), LEF1(1), LMO7(6), MAPK1(2), MAPK3(1), MET(10), MLLT4(7), NLK(1), PARD3(2), PTPN1(1), PTPRB(7), PTPRF(5), PTPRJ(4), PTPRM(7), PVRL1(1), PVRL3(2), PVRL4(1), RAC1(1), RAC2(1), SMAD2(3), SMAD3(3), SORBS1(1), SSX2IP(1), TCF7L2(4), TGFBR1(2), TGFBR2(3), TJP1(5), VCL(1), WAS(2), WASF1(1), WASF2(1), WASF3(3), WASL(2), YES1(2)	89799617	175	93	175	48	55	18	22	47	32	1	0.0295	1.000	1.000
469	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ATF4(1), CACNA1C(2), CACNA1D(7), CACNA1F(6), CACNA1S(7), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), ELK1(3), GNA11(1), GNAS(4), GNRHR(2), HBEGF(1), ITPR1(4), ITPR2(13), ITPR3(13), KRAS(3), MAP2K2(1), MAP2K3(3), MAP3K1(4), MAP3K3(2), MAP3K4(4), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(5), MAPK8(2), MAPK9(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLD1(7), PRKACG(1), PRKCA(5), PTK2B(2), RAF1(1), SOS1(4), SOS2(5)	95248589	181	93	181	68	65	23	27	37	26	3	0.302	1.000	1.000
470	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(2), ADCY8(1), ARAF(1), ATF4(1), BRAF(6), CACNA1C(2), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CREBBP(9), EP300(5), GRIA1(5), GRIA2(2), GRIN1(2), GRIN2A(8), GRIN2B(7), GRIN2C(4), GRIN2D(4), GRM1(4), GRM5(4), ITPR1(4), ITPR2(13), ITPR3(13), KRAS(3), MAP2K2(1), MAPK1(2), MAPK3(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), RAF1(1), RAPGEF3(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(3)	76012608	157	91	156	43	47	15	21	47	24	3	0.0379	1.000	1.000
471	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADK(1), ADSL(4), AK5(2), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(1), ATIC(1), ATP1B1(1), ATP5B(2), ATP5G2(1), CANT1(4), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(3), GART(4), GDA(1), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HPRT1(1), IMPDH1(4), NPR1(1), NPR2(3), NT5C(3), NT5E(1), NT5M(1), PAICS(2), PDE1A(1), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE5A(1), PDE6B(3), PDE6C(7), PDE7B(2), PDE8A(6), PDE9A(2), PFAS(6), PKLR(2), POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1), PPAT(2), PRPS1(1), PRPS1L1(1), PRPS2(3), RRM1(3)	98341081	175	91	175	72	55	35	19	43	23	0	0.629	1.000	1.000
472	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), AKAP1(1), AKAP11(2), AKAP12(1), AKAP2(3), AKAP3(2), AKAP4(6), AKAP5(2), AKAP6(9), AKAP7(1), AKAP8(4), AKAP9(10), ARHGEF1(1), CALM3(1), GNA11(1), GNA13(2), GNA14(3), GNA15(1), GNAI2(1), GNAI3(2), GNAL(1), GNAO1(2), GNAZ(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), ITPR1(4), KCNJ3(1), KRAS(3), PALM2(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE7A(2), PDE7B(2), PDE8A(6), PDE8B(1), PLCB3(4), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), RRAS(1), USP5(1)	89416452	149	88	149	68	42	23	16	35	31	2	0.874	1.000	1.000
473	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG10B(2), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(3), B3GNT2(1), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(3), CHST13(2), CHST3(3), CHST4(1), CHSY1(2), DAD1(1), DPAGT1(2), EXT1(3), EXT2(2), EXTL1(3), EXTL2(2), EXTL3(1), FUT11(1), FUT8(6), GALNT1(4), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(2), GALNT14(4), GALNT2(2), GALNT3(1), GALNT4(3), GALNT5(3), GALNT6(3), GALNT7(1), GALNT8(1), GALNT9(2), GALNTL5(1), GANAB(4), GCNT3(1), GCNT4(2), HS3ST1(1), HS3ST3A1(1), HS6ST2(4), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), MGAT5B(1), NDST1(2), NDST2(2), NDST3(3), NDST4(2), OGT(8), RPN1(1), RPN2(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(1), ST6GALNAC1(2), STT3B(2), WBSCR17(5), XYLT1(2), XYLT2(2)	84566367	160	88	159	48	52	29	21	36	22	0	0.0750	1.000	1.000
474	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(3), ACVR1B(4), ACVRL1(5), AKT1(1), BMPR1A(1), BUB1(4), CDS2(2), CLK1(2), CLK2(1), CLK4(2), CSNK2A1(2), CSNK2B(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), INPP4A(1), INPP4B(4), INPPL1(5), MAP3K10(1), NEK1(2), NEK3(2), OCRL(5), PAK4(1), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3CB(3), PIK3CG(5), PIM2(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCG1(6), PLCG2(9), PLK3(1), PRKACG(1), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), PRKG1(1), RAF1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), STK11(1), TGFBR1(2), VRK1(3)	84657018	151	87	150	58	46	23	18	36	25	3	0.658	1.000	1.000
475	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(4), ACTN1(1), ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), ARHGEF6(5), BCAR1(3), BRAF(6), CDKN2A(4), DOCK1(1), EPHB2(2), FYN(1), GRB7(4), ILK(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MRAS(1), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PIK3CB(3), PKLR(2), PLCG1(6), PLCG2(9), PTK2(2), RAF1(1), RALA(2), RHO(1), ROCK1(2), ROCK2(4), SHC1(1), SOS1(4), SOS2(5), TERF2IP(1), TLN1(5), TLN2(7), WAS(2)	91381994	161	85	159	45	46	22	22	46	25	0	0.0445	1.000	1.000
476	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	80	ABL1(4), ABL2(1), AKT1(1), ARAF(1), AREG(2), BRAF(6), BTC(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CBL(1), CBLB(2), CBLC(2), CDKN1A(1), CDKN1B(3), CRKL(1), EGF(7), ELK1(3), ERBB2(2), ERBB3(4), ERBB4(5), EREG(1), HBEGF(1), KRAS(3), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), NRG1(3), NRG2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PRKCA(5), PRKCG(2), PTK2(2), RAF1(1), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), STAT5A(1), STAT5B(2)	73130984	145	80	143	37	39	20	20	34	30	2	0.0281	1.000	1.000
477	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(1), ABCA12(4), ABCA13(17), ABCA2(4), ABCA3(5), ABCA4(7), ABCA5(4), ABCA6(6), ABCA7(10), ABCA8(5), ABCA9(3), ABCB1(5), ABCB10(3), ABCB11(1), ABCB4(6), ABCB5(6), ABCB7(5), ABCB8(1), ABCB9(2), ABCC1(5), ABCC10(11), ABCC11(7), ABCC12(4), ABCC2(1), ABCC3(6), ABCC4(4), ABCC5(4), ABCC6(1), ABCC8(6), ABCC9(6), ABCD1(2), ABCD2(1), ABCG1(1), ABCG2(1), ABCG4(3), ABCG5(3), ABCG8(4), CFTR(4), TAP1(1)	90460006	176	79	176	67	47	29	27	52	18	3	0.439	1.000	1.000
478	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(1), CASP8(2), CCL5(1), CD14(1), CD40(1), CD86(1), CXCL9(1), FOS(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IKBKB(1), IKBKE(5), IL12B(2), IL1B(2), IL6(1), IRAK1(1), IRAK4(2), IRF3(1), IRF5(1), IRF7(4), LBP(2), MAP2K2(1), MAP2K3(3), MAP3K8(4), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK9(1), NFKB1(1), NFKB2(2), NFKBIA(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(3), SPP1(2), STAT1(2), TBK1(2), TICAM1(1), TLR1(4), TLR2(1), TLR3(5), TLR4(2), TLR5(2), TLR6(3), TLR7(6), TLR9(3), TNF(1), TOLLIP(1), TRAF3(2), TRAF6(1)	65916165	123	75	122	47	32	22	20	32	15	2	0.375	1.000	1.000
479	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), BCAR1(3), CAPN10(4), CAPN11(4), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(5), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ILK(1), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAD(3), ITGAE(6), ITGAL(2), ITGAM(2), ITGAV(3), ITGAX(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(3), MAPK10(1), MAPK12(2), MAPK4(2), MAPK7(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PIK3R2(1), PTK2(2), RAC1(1), RAC2(1), RAPGEF1(4), RHO(1), ROCK1(2), ROCK2(4), SDCCAG8(2), SHC1(1), SHC3(1), SORBS1(1), SOS1(4), TLN1(5), TNS1(3), VAV2(2), VAV3(2), VCL(1)	102578608	162	75	162	56	49	22	25	40	25	1	0.268	1.000	1.000
480	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(2), CLK2(1), CLK3(3), CLK4(2), COL2A1(5), CPSF1(2), CPSF2(2), CPSF3(3), CSTF1(2), CSTF2(3), CSTF3(4), DDIT3(2), DHX15(1), DHX16(4), DHX38(4), DHX8(7), DHX9(2), DICER1(2), FUS(3), METTL3(4), NCBP1(1), NONO(2), PAPOLA(5), PHF5A(2), POLR2A(7), PRPF18(1), PRPF4(1), PRPF4B(3), PRPF8(10), PSKH1(1), PTBP1(2), RNGTT(4), SF3A3(1), SF3B1(7), SF3B2(2), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPE(1), SNURF(2), SPOP(4), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), TXNL4A(1), U2AF1(3), U2AF2(3), XRN2(5)	81017128	137	75	136	33	41	23	14	39	19	1	0.0687	1.000	1.000
481	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(5), ASH2L(2), CTCFL(5), DOT1L(3), EHMT1(6), EHMT2(3), EZH1(2), EZH2(2), FBXO11(2), HCFC1(7), HSF4(2), JMJD4(1), JMJD6(3), KDM6A(3), MEN1(1), NSD1(4), OGT(8), PAXIP1(2), PPP1CA(1), PPP1CB(1), PRDM2(5), PRDM7(1), PRDM9(8), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), RBBP5(1), SATB1(3), SETD1A(1), SETD2(13), SETD7(2), SETD8(1), SETDB1(7), SETDB2(1), SETMAR(3), STK38(1), SUV39H1(2), SUV420H1(2), SUZ12(1), WHSC1L1(4)	91004114	130	73	130	31	36	20	20	32	22	0	0.0275	1.000	1.000
482	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(3), ACVR1B(4), ACVR1C(1), ACVR2A(2), ACVRL1(5), AMHR2(1), BMP4(2), BMP5(4), BMP6(2), BMPR1A(1), BMPR1B(1), CHRD(1), COMP(1), CREBBP(9), CUL1(1), DCN(2), E2F5(1), EP300(5), FST(1), GDF5(1), GDF6(1), GDF7(1), INHBA(1), INHBB(1), INHBE(2), LEFTY2(2), LTBP1(7), MAPK1(2), MAPK3(1), NODAL(1), PITX2(4), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), RBL1(4), RBL2(4), RBX1(1), ROCK1(2), ROCK2(4), RPS6KB1(2), RPS6KB2(3), SMAD1(4), SMAD2(3), SMAD3(3), SMAD5(1), SMAD6(1), SMAD7(2), SMAD9(3), SMURF1(2), SMURF2(2), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNF(1), ZFYVE16(1), ZFYVE9(1)	76135113	153	72	153	43	45	22	24	41	20	1	0.0438	1.000	1.000
483	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	88	AKT1(1), CARD11(3), CBL(1), CBLB(2), CBLC(2), CD28(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FOS(1), FYN(1), GRAP2(1), ICOS(1), IKBKB(1), IL10(1), IL5(1), ITK(1), KRAS(3), LAT(2), LCK(1), LCP2(1), MALT1(2), MAP3K8(4), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PDK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPRC(7), RASGRP1(1), SOS1(4), SOS2(5), TEC(3), TNF(1), VAV1(5), VAV2(2), VAV3(2), ZAP70(5)	73976312	137	72	136	43	37	28	17	35	18	2	0.140	1.000	1.000
484	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(2), BRAF(6), CREB1(1), DAXX(2), ELK1(3), FOS(1), IKBKB(1), MAP2K2(1), MAP2K3(3), MAP2K5(2), MAP3K1(4), MAP3K10(1), MAP3K12(5), MAP3K13(3), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K8(4), MAP3K9(3), MAP4K1(1), MAP4K3(2), MAP4K4(2), MAP4K5(1), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(2), MAPK7(5), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), MKNK1(2), NFKB1(1), NFKBIA(2), PAK1(2), PAK2(2), RAC1(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA5(1), RPS6KB1(2), RPS6KB2(3), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	72757665	129	70	126	43	32	14	22	31	28	2	0.341	1.000	1.000
485	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	ABL1(4), ATM(8), BUB1(4), BUB1B(2), BUB3(3), CCNA1(2), CCNB1(2), CCNB2(1), CCNB3(4), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(5), CDC20(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(4), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(4), CHEK1(3), CHEK2(3), DTX4(2), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(5), ESPL1(6), HDAC2(4), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(3), MCM2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), MPEG1(2), MPL(2), PLK1(2), PRKDC(11), PTPRA(4), RB1(7), RBL1(4), SKP2(2), TBC1D8(1), WEE1(1)	83413852	148	66	148	49	27	28	21	39	30	3	0.395	1.000	1.000
486	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(11), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ADIPOR1(2), ADIPOR2(3), AGRP(1), AKT1(1), CAMKK1(1), CAMKK2(2), CD36(4), CPT1A(1), CPT1C(1), CPT2(1), G6PC(7), G6PC2(1), IKBKB(1), IRS1(4), IRS2(1), IRS4(6), JAK1(1), JAK2(4), JAK3(3), LEPR(2), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), NPY(3), PCK1(3), PPARA(3), PPARGC1A(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKCQ(2), PTPN11(7), RELA(1), RXRA(1), RXRG(3), SLC2A1(2), SLC2A4(1), STAT3(2), STK11(1), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(7)	63579952	130	66	128	46	37	25	9	38	20	1	0.293	1.000	1.000
487	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), ALG6(3), CCKBR(2), CCR2(2), CCR3(1), CELSR1(9), CELSR2(12), CELSR3(13), CHRM3(3), EDNRA(1), EMR2(5), EMR3(1), F2R(2), FSHR(2), GHRHR(2), GNRHR(2), GPR116(6), GPR132(5), GPR133(4), GPR143(4), GPR17(1), GPR18(2), GPR61(3), GPR84(2), GRM1(4), GRPR(3), HRH4(2), LPHN2(7), LPHN3(5), LTB4R2(1), NTSR1(1), P2RY13(1), PTGFR(6), SMO(2), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(1)	51080574	130	65	129	41	41	28	19	31	11	0	0.0386	1.000	1.000
488	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1C1(1), AKR1C2(1), AKR1C3(1), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), CYP1A2(2), CYP1B1(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2S1(1), CYP3A4(3), CYP3A7(2), EPHX1(3), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(2), GSTA5(3), GSTK1(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2)	43971362	112	65	111	35	32	14	19	35	12	0	0.209	1.000	1.000
489	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP4A(1), INPP4B(4), INPP5B(3), INPPL1(5), IPMK(2), ISYNA1(2), ITPK1(3), MINPP1(1), OCRL(5), PI4KA(7), PI4KB(2), PIK3C3(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(5), PTPMT1(1), SYNJ1(6), SYNJ2(8)	54701985	114	64	113	36	30	22	13	32	17	0	0.247	1.000	1.000
490	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(3), CD14(1), CD19(1), CD1A(3), CD1B(4), CD1E(4), CD22(3), CD33(1), CD36(4), CD3D(1), CD4(1), CD44(3), CD55(1), CD7(1), CR1(5), CR2(5), CSF1R(4), CSF3R(2), DNTT(1), EPO(1), EPOR(1), FCGR1A(1), FLT3(4), GP5(2), GP9(1), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), IL1B(2), IL1R1(2), IL1R2(3), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL7R(2), IL9R(2), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGAM(2), ITGB3(2), KIT(6), KITLG(2), MME(2), MS4A1(3), TFRC(2), THPO(1), TNF(1), TPO(6)	61642197	128	64	128	44	30	28	19	35	16	0	0.162	1.000	1.000
491	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), CABIN1(6), CALM3(1), CAMK4(2), CDKN1A(1), CEBPB(1), CNR1(1), CREBBP(9), CSNK2A1(2), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(1), EP300(5), FCER1A(2), FCGR3A(1), FOS(1), GATA3(3), GATA4(1), ICOS(1), IFNB1(1), IL10(1), IL1B(2), IL3(1), IL6(1), ITK(1), KPNA5(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB2(2), NFKBIE(1), NUP214(2), OPRD1(1), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(7), RELA(1), RPL13A(1), SFN(2), SLA(2), SP3(4), TNF(1), TRAF2(2), TRPV6(7), VAV1(5), VAV2(2), VAV3(2), XPO5(1)	69732822	127	63	127	39	31	31	15	30	19	1	0.0752	1.000	1.000
492	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(5), CANT1(4), CDA(1), CTPS2(2), DCK(1), DCTD(1), DHODH(2), DPYD(4), DPYS(4), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1), POLA1(2), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(1), RRM1(3), RRM2B(1), TK2(3), TXNRD2(3), UCK1(3), UMPS(1), UPP1(1), UPP2(2), UPRT(2)	61991576	114	61	113	36	24	16	14	39	21	0	0.359	1.000	1.000
493	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(3), ATP8A1(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), CCKBR(2), CCR10(1), CCR2(2), CCR3(1), CCR4(2), CCR6(2), CCR7(1), CCR8(1), CX3CR1(1), CXCR4(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(2), GNRHR(2), GRPR(3), MC1R(3), MC3R(2), MC4R(3), MC5R(3), NMBR(5), NPY1R(3), NPY2R(1), NTSR1(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), SSTR2(3), SSTR3(5), SSTR4(8), TACR2(2), TACR3(3), TRHR(2), TSHR(4)	40220137	100	61	100	48	32	12	24	26	6	0	0.771	1.000	1.000
494	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(5), ADCY8(1), CACNA1A(3), CACNA1B(9), GNAS(4), GNAT3(1), GNB3(1), GRM4(4), ITPR3(13), KCNB1(3), PDE1A(1), PLCB2(4), PRKACG(1), SCNN1B(3), SCNN1G(2), TAS1R2(3), TAS1R3(1), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R16(4), TAS2R3(1), TAS2R38(1), TAS2R4(2), TAS2R40(2), TAS2R41(3), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R7(1), TAS2R9(4), TRPM5(2)	43585423	88	60	88	32	34	15	9	21	9	0	0.395	1.000	1.000
495	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(1), BTK(3), FCER1A(2), FYN(1), GAB2(3), IL3(1), IL5(1), INPP5D(2), KRAS(3), LAT(2), LCP2(1), MAP2K2(1), MAP2K3(3), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK9(1), PDK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(9), PRKCA(5), RAC1(1), RAC2(1), RAF1(1), SOS1(4), SOS2(5), TNF(1), VAV1(5), VAV2(2), VAV3(2)	52094964	105	59	104	34	30	19	14	26	13	3	0.159	1.000	1.000
496	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(8), CCNA1(2), CCNB1(2), CCND1(4), CCNE1(1), CCNE2(1), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), CREB3L1(1), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(1), MCM2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), MYT1(7), NACA(5), POLA2(1), POLE(8), PRIM1(1), RB1(7), RBL1(4), RPA1(3), TFDP2(1), TNXB(11), WEE1(1)	58562644	107	58	107	34	19	10	16	26	36	0	0.480	1.000	1.000
497	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(1), BCR(3), BLNK(2), BTK(3), CD19(1), CD22(3), CD81(2), CR2(5), CSK(1), DAG1(1), FLOT2(3), INPP5D(2), ITPR1(4), ITPR2(13), ITPR3(13), MAP4K1(1), MAPK1(2), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(2), PIK3CD(3), PLCG2(9), PPP1R13B(2), PPP3CA(1), PPP3CC(1), PTPRC(7), RAF1(1), SHC1(1), SOS1(4), SOS2(5), VAV1(5)	53760119	109	58	109	36	35	18	12	31	11	2	0.143	1.000	1.000
498	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	CREBBP(9), CTBP1(5), CTBP2(1), DLL3(1), DTX1(4), DTX3L(1), DTX4(2), DVL2(1), DVL3(2), EP300(5), HDAC2(4), JAG1(4), JAG2(1), LFNG(2), MAML1(4), MAML2(2), MAML3(4), MFNG(1), NCOR2(8), NCSTN(4), NOTCH2(11), NOTCH3(6), NOTCH4(8), NUMB(1), NUMBL(2), RBPJL(2), SNW1(2)	49080954	97	55	97	36	30	13	9	20	24	1	0.599	1.000	1.000
499	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), ARHGAP1(1), ARHGAP4(2), ARHGEF11(2), BTK(3), CFL1(1), CFL2(1), GDI1(3), GDI2(1), INPPL1(5), ITPR1(4), ITPR2(13), ITPR3(13), LIMK1(4), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PDK1(2), PIK3CD(3), PIK3CG(5), PITX2(4), PPP1R13B(2), RHO(1), ROCK1(2), ROCK2(4), RPS4X(2), SAG(2), WASF1(1), WASL(2)	50254520	111	55	111	31	29	22	21	29	9	1	0.0531	1.000	1.000
500	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(1), KDR(6), KRAS(3), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NOS3(7), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(9), PPP3CA(1), PPP3CC(1), PRKCA(5), PRKCG(2), PTGS2(2), PTK2(2), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2)	51964879	105	54	104	34	31	16	18	22	16	2	0.133	1.000	1.000
501	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(1), ACADM(2), ACOX1(2), ACOX2(3), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ANGPTL4(1), APOA1(1), AQP7(3), CD36(4), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(1), CYP4A22(2), CYP7A1(2), CYP8B1(1), DBI(1), EHHADH(1), FABP4(1), FABP6(1), FABP7(1), FADS2(2), GK(1), GK2(4), HMGCS2(3), ILK(1), LPL(2), ME1(1), MMP1(1), NR1H3(5), OLR1(1), PCK1(3), PPARA(3), PPARG(2), RXRA(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A4(1), SLC27A5(4), SORBS1(1), UBC(5)	50116493	97	52	96	35	23	21	12	27	14	0	0.336	1.000	1.000
502	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(5), AKT1(1), APAF1(3), ATM(8), BAX(1), BIRC2(2), CASP8(2), CFLAR(1), CSF2RB(2), CYCS(2), DFFA(2), FAS(1), FASLG(1), IKBKB(1), IL1B(2), IL1R1(2), IL1RAP(1), IL3(1), IL3RA(2), IRAK1(1), IRAK2(2), IRAK3(6), IRAK4(2), NFKB1(1), NFKB2(2), NFKBIA(2), NTRK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RELA(1), RIPK1(3), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TRADD(1), TRAF2(2)	60507228	87	50	87	33	19	14	12	26	16	0	0.706	1.000	1.000
503	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(2), BMP5(4), BMP6(2), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(2), GLI1(3), GLI2(3), GLI3(7), HHIP(2), IHH(3), LRP2(22), PRKACG(1), PTCH1(3), RAB23(1), SHH(1), SMO(2), STK36(2), SUFU(3), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1), ZIC2(1)	46743626	90	50	90	36	33	15	13	18	11	0	0.572	1.000	1.000
504	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(2), APOA1(1), CD36(4), CITED2(1), CREBBP(9), DUSP1(1), EHHADH(1), EP300(5), HSD17B4(2), LPL(2), MAPK1(2), MAPK3(1), ME1(1), NCOA1(2), NCOR1(9), NCOR2(8), NFKBIA(2), NR1H3(5), NR2F1(1), NRIP1(2), PDGFA(1), PPARA(3), PRKACG(1), PRKAR1A(2), PRKCA(5), PTGS2(2), RB1(7), RELA(1), RXRA(1), STAT5A(1), STAT5B(2), TNF(1)	45623274	88	49	86	30	22	12	11	21	19	3	0.491	1.000	1.000
505	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), AANAT(1), ACAT2(1), ACMSD(1), AFMID(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), AOX1(5), ASMT(1), CAT(3), CYP1A2(2), CYP1B1(1), DDC(3), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), HSD17B4(2), KMO(3), KYNU(1), LCMT1(2), LCMT2(1), LNX1(4), MAOA(2), METTL2B(3), METTL6(1), NFX1(2), OGDH(1), OGDHL(4), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), TDO2(2), TPH1(4), TPH2(3), WARS2(2), WBSCR22(2)	46426041	92	48	92	31	30	12	12	24	14	0	0.295	1.000	1.000
506	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(5), ALPPL2(2), ASCC3(3), ATP13A2(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(2), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(3), DHFR(1), DHX58(1), ENTPD7(2), EP400(3), ERCC2(3), ERCC3(2), FPGS(2), GGH(1), IFIH1(4), MOV10L1(3), QDPR(2), RAD54B(3), RAD54L(5), RUVBL2(2), SETX(4), SKIV2L2(3), SMARCA2(2), SMARCA5(2), SPR(1)	48093737	83	48	83	29	26	15	10	17	15	0	0.483	1.000	1.000
507	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(1), BLNK(2), BTK(3), CARD11(3), CD19(1), CD22(3), CD72(3), CD79A(1), CD81(2), CR2(5), FOS(1), IFITM1(1), IKBKB(1), INPP5D(2), KRAS(3), LILRB3(2), MALT1(2), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG2(9), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RASGRP3(2), VAV1(5), VAV2(2), VAV3(2)	53757176	97	48	97	37	33	22	5	21	15	1	0.312	1.000	1.000
508	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT2(1), ACMSD(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), AOX1(5), ASMT(1), CAT(3), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2A7(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(2), CYP4B1(1), CYP51A1(2), DDC(3), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), KMO(3), KYNU(1), MAOA(2), SDS(1), TDO2(2), TPH1(4), WARS2(2)	42195996	78	47	78	27	28	11	6	20	13	0	0.396	1.000	1.000
509	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(3), BAK1(2), BAX(1), BCL2L11(1), BIRC2(2), CASP1(5), CASP2(1), CASP4(1), CASP8(2), CYCS(2), DFFA(2), FAS(1), FASLG(1), GZMB(1), HELLS(3), IKBKB(1), IRF1(4), IRF2(1), IRF3(1), IRF4(2), IRF5(1), IRF6(2), IRF7(4), MAP3K1(4), MAPK10(1), MDM2(3), NFKB1(1), NFKBIA(2), NFKBIE(1), PLEKHG5(3), PRF1(3), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(1), TRADD(1), TRAF2(2), TRAF3(2)	43208887	77	42	77	27	28	12	5	20	12	0	0.405	1.000	1.000
510	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ADCY3(2), ADCY9(7), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(3), PLCG1(6), PLCG2(9), PRKCA(5), SEC61A1(1), TRIM23(2)	28366340	56	39	55	22	22	11	6	8	8	1	0.533	1.000	1.000
511	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4A(1), INPP4B(4), INPPL1(5), OCRL(5), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3CB(3), PIK3CG(5), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCG1(6), PLCG2(9)	32645013	60	39	59	26	16	12	7	17	8	0	0.775	1.000	1.000
512	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(2), ACTG1(2), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCL(2), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(3), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3), WAS(2), WASL(2), YWHAQ(1), YWHAZ(1)	39734108	70	38	70	27	24	11	11	15	8	1	0.474	1.000	1.000
513	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(2), ACTG1(2), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCL(2), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(3), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3), WAS(2), WASL(2), YWHAQ(1), YWHAZ(1)	39734108	70	38	70	27	24	11	11	15	8	1	0.474	1.000	1.000
514	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(3), ACADL(1), ACADM(2), ACADS(2), ACADVL(2), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(1), CYP4A22(2), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), HSD17B4(2)	37531855	68	35	68	31	16	9	7	20	16	0	0.836	1.000	1.000
515	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), DAG1(1), DGKA(3), ITPR1(4), ITPR2(13), ITPR3(13), MAPK1(2), MAPK3(1), PAK1(2), PDE3A(2), PI3(2), PIK3C2G(1), PIK3CD(3), PSME1(3), RIPK3(1), RPS4X(2), SGCB(1)	34427863	60	35	60	27	14	5	14	15	10	2	0.836	1.000	1.000
516	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(2), CCND1(4), CREBBP(9), EP300(5), ERCC3(2), ESR1(2), GRIP1(2), GTF2E1(3), GTF2F1(1), HDAC2(4), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(3), NCOR2(8), NR0B1(1), NRIP1(2), PELP1(2), POLR2A(7)	35376817	62	34	61	25	22	4	5	17	14	0	0.788	1.000	1.000
517	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), ACAT2(1), AKR1B10(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), DOT1L(3), ECHS1(2), EHHADH(1), EHMT1(6), EHMT2(3), GCDH(1), HADHA(2), HSD17B4(2), HSD3B7(1), NSD1(4), OGDH(1), OGDHL(4), PIPOX(1), PLOD1(3), PLOD2(2), PLOD3(1), SETD1A(1), SETD7(2), SETDB1(7), SHMT1(2), SUV39H1(2), TMLHE(2)	44501817	73	34	73	29	26	7	9	19	12	0	0.563	1.000	1.000
518	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(2), CBR3(1), CYP4F3(5), EPX(5), GGT1(2), LPO(5), LTA4H(4), MPO(2), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(2), TBXAS1(2), TPO(6)	21373742	55	34	55	20	17	13	6	11	7	1	0.274	1.000	1.000
519	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP4(2), ARHGAP5(2), ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(1), ARPC1A(1), ARPC1B(2), ARPC3(1), BAIAP2(3), CFL1(1), DIAPH1(5), GSN(1), LIMK1(4), MYL2(2), MYLK(5), OPHN1(4), PIP5K1B(1), ROCK1(2), TLN1(5), VCL(1)	34768823	52	34	52	20	13	5	7	20	7	0	0.647	1.000	1.000
520	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(8), IL6ST(3), MRPL19(2), RPL10(4), RPL13A(1), RPL15(1), RPL18A(1), RPL23(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36(1), RPL5(3), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(2), RPS19(1), RPS2(1), RPS24(1), RPS3(3), RPS4X(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(3), RPS6KB1(2), RPS6KB2(3), SLC36A2(1), TBC1D10C(1), UBC(5)	40100721	72	34	72	21	15	11	8	25	13	0	0.421	1.000	1.000
521	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), ARHGEF11(2), DLG4(3), GNA13(2), LPA(7), MAP3K1(4), MAP3K5(3), MAPK8(2), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PDK1(2), PHKA2(5), PI3(2), PIK3CB(3), PLD1(7), PLD3(1), PTK2(2), RDX(5), ROCK1(2), ROCK2(4), SERPINA4(2), SRF(2), TBXA2R(1)	37641980	68	34	68	23	18	11	12	18	8	1	0.399	1.000	1.000
522	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAX(1), CASP1(5), CASP2(1), CASP4(1), CASP8(2), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(2), FAS(1), FASLG(1), IKBKE(5), NFKB1(1), NFKBIA(2), NGFR(1), NR3C1(3), NTRK1(2), PTPN13(3), RIPK1(3), TFG(1), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(2), TRAF6(1)	33278537	55	33	55	21	17	9	4	14	11	0	0.567	1.000	1.000
523	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	AKT1(1), CALM3(1), CHRM1(2), CHRNA1(4), FLT1(5), FLT4(6), KDR(6), NOS3(7), PDE2A(4), PDE3A(2), PRKACG(1), PRKAR1A(2), PRKG1(1), PRKG2(1), SLC7A1(2), SYT1(2), TNNI1(1)	24323540	48	33	48	25	14	7	12	9	6	0	0.842	1.000	1.000
524	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(3), AKT1(1), DAG1(1), ITPR1(4), ITPR2(13), ITPR3(13), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PDK1(2), PHKA2(5), PIK3CB(3), PITX2(4), PLD1(7), PLD3(1), VN1R1(1)	34374586	64	33	64	27	21	8	12	18	3	2	0.636	1.000	1.000
525	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(2), ALAS1(1), ALAS2(1), AMT(1), ATP6V0C(1), CBS(4), CHKB(1), CTH(1), DLD(1), DMGDH(1), GARS(3), GCAT(1), GLDC(2), MAOA(2), PISD(1), PLCB2(4), PLCG1(6), PLCG2(9), PSPH(2), SARDH(3), SARS(1), SHMT1(2)	32210602	52	31	51	20	16	17	3	9	7	0	0.304	1.000	1.000
526	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALNT1(2), B4GALT6(1), FUT1(1), FUT2(2), FUT5(3), FUT6(2), GBGT1(1), PIGA(3), PIGB(1), PIGC(1), PIGG(2), PIGN(1), PIGO(3), PIGQ(3), PIGS(2), PIGT(1), PIGU(1), PIGX(1), PIGZ(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST3GAL6(3), ST6GALNAC3(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(3), UGCG(2)	37229089	65	31	65	25	24	6	5	19	11	0	0.638	1.000	1.000
527	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(2), CAMK2D(1), CAMK2G(2), DAG1(1), ITPR1(4), ITPR2(13), ITPR3(13), NFAT5(4), PDE6A(2), PDE6B(3), PDE6C(7), SLC6A13(2), TF(2)	27452725	56	31	56	23	17	11	10	12	5	1	0.486	1.000	1.000
528	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), ELK1(3), FOS(1), IKBKB(1), IRAK1(1), MAP2K3(3), MAP3K1(4), MAPK8(2), NFKB1(1), NFKBIA(2), PPARA(3), RELA(1), TLR10(5), TLR2(1), TLR3(5), TLR4(2), TLR6(3), TLR7(6), TLR9(3), TOLLIP(1), TRAF6(1)	27995434	50	31	49	19	16	7	8	15	4	0	0.529	1.000	1.000
529	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH4A1(2), ARG2(2), ASL(2), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), GLUD1(5), GOT1(2), MAOA(2), NOS1(6), NOS3(7), OAT(1), ODC1(3), P4HA1(1), RARS(2), SMS(1)	33849189	60	30	60	25	17	12	6	14	11	0	0.630	1.000	1.000
530	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(1), CD97(2), CRHR2(3), ELTD1(1), EMR1(4), EMR2(5), GHRHR(2), GIPR(2), GLP1R(1), GLP2R(1), GPR64(3), LPHN1(1), LPHN2(7), LPHN3(5), SCTR(1), VIPR1(1), VIPR2(1)	20442745	45	29	45	20	11	8	10	14	2	0	0.748	1.000	1.000
531	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG2(2), ASL(2), ASS1(3), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), EPRS(3), GLUD1(5), GLUD2(1), GOT1(2), LAP3(1), NOS1(6), NOS3(7), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4)	27487712	53	29	53	22	15	11	5	13	9	0	0.661	1.000	1.000
532	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(13), C5(6), C6(3), C7(5), ICAM1(2), IL6(1), ITGA4(5), ITGAL(2), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), TNF(1), VCAM1(1)	19006134	45	29	45	19	14	6	7	11	7	0	0.572	1.000	1.000
533	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(1), EIF2B4(1), EIF2S2(1), FLT1(5), FLT4(6), KDR(6), NOS3(7), PLCG1(6), PRKCA(5), PTK2(2), SHC1(1)	23157931	41	28	40	22	9	6	8	11	6	1	0.931	1.000	1.000
534	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(2), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(10), MAN2B1(2), MAN2B2(5), MAN2C1(2), MANBA(1), NEU1(1), NEU2(6), NEU3(2)	15619214	39	27	39	17	12	3	6	12	6	0	0.796	1.000	1.000
535	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC10(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(2), CDC27(4), CUL1(1), CUL2(6), CUL3(1), FBXW7(4), FZR1(3), RBX1(1), SKP2(2), SMURF1(2), SMURF2(2), UBE2D4(2), WWP1(3), WWP2(1)	30839537	48	26	48	24	13	7	9	15	4	0	0.942	1.000	1.000
536	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(1), ANKRD6(2), APC(2), AXIN1(1), AXIN2(1), CSNK1A1(2), CTNNB1(3), DACT1(3), DKK1(1), DKK2(2), DKK4(2), LRP1(20), NKD1(1), PTPRA(4), SENP2(3), SFRP1(1), WIF1(3)	30499944	52	26	52	21	14	9	5	16	8	0	0.774	1.000	1.000
537	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2), C8B(4), MASP1(2)	15914567	47	25	47	22	18	6	3	14	6	0	0.799	1.000	1.000
538	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2), MASP1(2), MBL2(3)	16276604	46	25	46	18	18	4	4	13	7	0	0.611	1.000	1.000
539	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(1), CREB1(1), DUSP1(1), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(3), IL1R1(2), MAP2K3(3), MAP3K10(1), MAP3K4(4), MAP3K5(3), MAPK1(2), MAPK12(2), MAPK13(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(2), MYEF2(3), NFKB1(1), NR2C2(2), SRF(2), TRAF6(1)	25528703	44	25	44	20	13	3	10	13	5	0	0.812	1.000	1.000
540	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA1(1), APOA4(3), APOE(2), CETP(1), CYP7A1(2), LIPC(1), LPL(2), LRP1(20), SOAT1(2)	20988506	40	25	40	18	10	8	4	14	4	0	0.803	1.000	1.000
541	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(1), CFL1(1), GNAS(4), LIMK1(4), MAPK1(2), MAPK3(1), MYL2(2), NOX1(1), PIK3C2G(1), PLCB1(3), PRKCA(5), PTK2(2), RAF1(1), ROCK2(4)	19268738	34	24	34	11	6	2	7	11	6	2	0.536	1.000	1.000
542	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(3), CXCR4(2), GNAI1(4), MAPK1(2), MAPK3(1), NFKB1(1), PIK3C2G(1), PLCG1(6), PRKCA(5), PTK2(2), PTK2B(2), RAF1(1), RELA(1)	18284198	31	24	30	18	7	3	7	6	6	2	0.940	1.000	1.000
543	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2)	13388883	41	23	41	17	16	3	3	13	6	0	0.712	1.000	1.000
544	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM3(1), CAMK1(1), CAMK1G(1), ELK1(3), FPR1(1), GNA15(1), MAP2K2(1), MAP2K3(3), MAP3K1(4), MAPK1(2), MAPK3(1), NCF1(2), NCF2(3), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIA(2), PAK1(2), PIK3C2G(1), PLCB1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1), SYT1(2)	29367336	53	23	53	21	15	6	7	13	11	1	0.511	1.000	1.000
545	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(2), AKR1B10(2), ALAS1(1), ALAS2(1), AMT(1), CBS(4), CHKB(1), CTH(1), DLD(1), DMGDH(1), GARS(3), GCAT(1), GLDC(2), HSD3B7(1), MAOA(2), PHGDH(4), PIPOX(1), PISD(1), PSAT1(2), PSPH(2), SARDH(3), SARS(1), SARS2(1), SDS(1), SHMT1(2), TARS2(1)	32685314	45	23	45	17	11	15	4	9	6	0	0.308	1.000	1.000
546	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(5), ARRB2(2), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CLCA1(3), CLCA2(4), CLCA4(1), CNGA3(4), CNGA4(2), CNGB1(3), GNAL(1), GUCA1A(1), PDC(2), PDE1C(5), PRKACG(1), PRKG1(1), PRKG2(1)	23391495	46	23	46	20	20	6	2	12	6	0	0.637	1.000	1.000
547	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	ACO2(4), DLD(1), FH(1), IDH3B(1), OGDH(1), PC(2), PDHA1(5), PDHA2(4), PDHB(1), PDK1(2), PDK3(3), PDK4(1), PDP2(2), SDHA(4), SDHC(2), SUCLG2(1)	21159370	35	23	33	13	7	6	7	9	6	0	0.482	1.000	1.000
548	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ATP6V0C(1), DOT1L(3), ECHS1(2), EHHADH(1), EHMT1(6), EHMT2(3), GCDH(1), HADHA(2), PLOD1(3), PLOD2(2), PLOD3(1), SDS(1), SHMT1(2), TMLHE(2)	28414456	50	23	50	21	18	7	7	10	8	0	0.500	1.000	1.000
549	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDK2(1), DIAPH2(2), GMNN(1), MCM10(4), MCM2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), NACA(5), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), PRIM1(1), RFC1(1), RFC4(3), RPA1(3), UBC(5)	38840177	57	22	57	32	7	7	7	21	15	0	0.987	1.000	1.000
550	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(2), GPRC5C(1), GPRC5D(2), GRM1(4), GRM2(4), GRM3(7), GRM4(4), GRM5(4), GRM7(3), GRM8(2)	16127851	35	22	35	19	14	5	2	9	5	0	0.867	1.000	1.000
551	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(3), ACAD8(2), ACAD9(1), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), BAAT(1), CEL(2), CYP27A1(1), CYP7A1(2), HSD3B7(1), LIPA(2), SLC27A5(4), SOAT1(2), SOAT2(1), SRD5A1(1)	24170731	52	22	52	25	13	5	8	21	5	0	0.906	1.000	1.000
552	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), DARS2(2), EARS2(1), EPRS(3), FARS2(3), GARS(3), HARS(2), HARS2(1), IARS(1), IARS2(3), LARS(4), MARS(5), MARS2(2), MTFMT(1), NARS(2), NARS2(1), PARS2(1), QARS(3), RARS(2), RARS2(4), SARS(1), SARS2(1), TARS2(1), VARS(3), VARS2(2), WARS2(2), YARS(1)	41584450	57	22	57	17	9	14	6	19	9	0	0.397	1.000	1.000
553	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLA2(1), POLB(3), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLG(1), POLH(1), POLI(3), POLK(2), POLL(1), POLM(3), POLQ(5), PRIM1(1), PRIM2(1), REV1(3), REV3L(7)	31048185	48	22	48	20	11	7	6	15	9	0	0.873	1.000	1.000
554	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BIRC2(2), CASP8(2), CFLAR(1), CYCS(2), DFFA(2), GAS2(1), LMNA(2), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), SPTAN1(5), TNFRSF25(1), TRADD(1), TRAF2(2)	25590668	31	21	31	11	9	7	3	8	4	0	0.481	1.000	1.000
555	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(2), ARHGEF1(1), F2(3), F2R(2), F2RL3(1), GNA13(2), GNAI1(4), PLCB1(3), PRKCA(5), PTK2B(2), ROCK1(2)	16926368	27	21	27	16	6	4	5	8	3	1	0.905	1.000	1.000
556	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(2), ANXA5(1), ANXA6(3), CYP11A1(4), EDNRA(1), EDNRB(1), PLA2G4A(4), PRL(1), PTGER4(1), PTGFR(6), PTGS1(2), PTGS2(2), SCGB1A1(1), TBXAS1(2)	15836398	35	21	35	16	9	3	4	13	6	0	0.822	1.000	1.000
557	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(1), CRADD(1), IKBKB(1), MAP2K3(3), MAP3K1(4), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TANK(3), TNF(1), TRADD(1), TRAF2(2)	18491315	27	21	27	11	9	6	2	5	5	0	0.630	1.000	1.000
558	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	AGT(2), AGTR2(3), EDNRA(1), EDNRB(1), EGF(7), FOS(1), NFKB1(1), PLCG1(6), PRKCA(5), RELA(1)	13714719	28	20	27	13	8	5	3	9	2	1	0.783	1.000	1.000
559	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPNS1(1), CAPNS2(1), EGF(7), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(5), PRKACG(1), PRKAR1A(2), PTK2(2), TLN1(5)	23034580	33	20	33	16	13	1	8	6	4	1	0.811	1.000	1.000
560	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2E1(3), GTF2F1(1), HDAC3(1), NCOA1(2), NCOA2(2), NCOA3(5), NCOR2(8), POLR2A(7), RXRA(1)	19106019	32	20	31	22	5	7	1	12	7	0	0.991	1.000	1.000
561	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(8), BRCA1(2), CDKN1A(1), CHEK1(3), CHEK2(3), MAPK8(2), MDM2(3), MRE11A(2), NFKB1(1), NFKBIA(2), RAD50(5), RBBP8(2), RELA(1)	22250704	39	19	39	13	9	8	6	11	5	0	0.540	1.000	1.000
562	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(1), ACADM(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), CNDP1(2), DPYD(4), DPYS(4), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), MLYCD(3), SDS(1), SMS(1)	22288062	41	19	40	17	12	7	3	11	8	0	0.641	1.000	1.000
563	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(3), ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), BAAT(1), CEL(2), CYP27A1(1), CYP7A1(2), SOAT2(1), SRD5A1(1)	17805446	36	19	36	17	10	4	5	13	4	0	0.802	1.000	1.000
564	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(3), F2R(2), FGA(6), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(2), SERPINE1(2)	10280444	25	19	25	10	8	3	3	7	4	0	0.632	1.000	1.000
565	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(2), EXTL1(3), EXTL2(2), EXTL3(1), HS3ST1(1), HS3ST3A1(1), HS6ST2(4), HS6ST3(1), NDST1(2), NDST2(2), NDST3(3), NDST4(2)	15901311	27	19	27	11	13	1	5	7	1	0	0.648	1.000	1.000
566	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(1), CBL(1), CFLAR(1), CRKL(1), E2F1(1), FOS(1), IL2RB(2), IRS1(4), JAK1(1), JAK3(3), MAPK1(2), MAPK3(1), RAF1(1), RPS6KB1(2), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2)	24842698	30	19	30	14	5	7	3	7	7	1	0.741	1.000	1.000
567	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(6), BCAR1(3), BCR(3), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(2), PTK2(2), RAF1(1), ROCK1(2), SHC1(1), SOS1(4), TLN1(5), VCL(1)	36157811	44	19	44	17	15	6	8	9	5	1	0.535	1.000	1.000
568	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(5), ITGAL(2), ITGAM(2), ITGB1(2), ITGB2(1), SELE(6), SELP(2)	12224334	25	19	24	11	9	4	7	3	2	0	0.588	1.000	1.000
569	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(9), DUSP1(1), EP300(5), IKBKB(1), IL1B(2), MAP2K3(3), NFKB1(1), NFKBIA(2), NR3C1(3), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1), TNF(1)	22767082	35	19	35	14	9	6	4	11	5	0	0.673	1.000	1.000
570	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(13), C5(6), C6(3), C7(5), C8A(2)	9622069	29	18	29	14	11	2	3	8	5	0	0.812	1.000	1.000
571	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), ELK1(3), FOS(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2)	17884778	25	18	25	10	4	6	2	7	5	1	0.526	1.000	1.000
572	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IL1R1(2), IRAK1(1), MAP3K1(4), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1B(2), TRADD(1), TRAF6(1)	18660552	24	18	24	14	11	3	2	4	4	0	0.897	1.000	1.000
573	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), AP2M1(1), ARF1(1), BTK(3), EEA1(3), GRASP(1), PFKL(5), PFKP(1), PLCG1(6), RAC1(1), RPS6KB1(2), VAV2(2)	19080196	28	18	27	16	8	7	3	5	5	0	0.859	1.000	1.000
574	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(2), GTF2A2(1), GTF2E1(3), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3B(2), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(1), TAF9(2)	26888480	39	18	39	25	10	6	4	15	4	0	0.986	1.000	1.000
575	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(2), CASP8(2), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), NR2C2(2), RALBP1(2), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1B(2), TRADD(1), TRAF2(2)	20859433	29	18	29	11	12	5	3	4	5	0	0.567	1.000	1.000
576	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(4), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TANK(3), TNFAIP3(2), TNFRSF1B(2), TRAF2(2), TRAF3(2)	17206442	25	18	25	10	12	3	1	4	5	0	0.564	1.000	1.000
577	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD7(1), IFNB1(1), IL10(1), IL12B(2), IL3(1), IL5(1), ITGAX(2), TLR2(1), TLR4(2), TLR7(6), TLR9(3)	14266044	25	17	24	15	6	2	4	10	3	0	0.949	1.000	1.000
578	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX2(2), GPX6(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(2), GSTA5(3), GSTK1(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), OPLAH(2)	15628527	29	17	29	14	8	8	5	5	3	0	0.727	1.000	1.000
579	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(3), CA1(1), CA12(2), CA13(1), CA14(1), CA2(1), CA5A(2), CPS1(3), CTH(1), GLS(2), GLS2(1), GLUD1(5), GLUD2(1), GLUL(1), HAL(1)	16296819	27	17	27	14	6	6	1	9	5	0	0.880	1.000	1.000
580	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1)	18000514	31	17	31	13	8	3	5	11	4	0	0.727	1.000	1.000
581	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(9), EP300(5), FYN(1), IL7R(2), JAK1(1), JAK3(3), LCK(1), PTK2B(2), STAT5A(1), STAT5B(2)	18575251	27	17	27	11	6	3	3	11	4	0	0.751	1.000	1.000
582	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR2(2), CCR3(1), CCR4(2), CCR7(1), CD28(1), CD4(1), CXCR4(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(2), IL5(1), TGFB2(2), TGFB3(1)	15318056	25	17	25	16	6	3	5	9	2	0	0.947	1.000	1.000
583	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX2(2), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), PGD(1)	12594975	23	16	23	13	6	4	5	4	4	0	0.894	1.000	1.000
584	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), CHST1(1), CHST4(1), FUT8(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3)	9568150	18	16	18	10	6	3	4	3	2	0	0.828	1.000	1.000
585	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(3), CA1(1), CA12(2), CA14(1), CA2(1), CA5A(2), CPS1(3), CTH(1), GLS(2), GLS2(1), GLUD1(5), GLUL(1), HAL(1)	14584452	25	16	25	10	6	5	1	8	5	0	0.672	1.000	1.000
586	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(9), EP300(5), HDAC3(1), IKBKB(1), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF6(1)	17157149	28	16	28	11	9	3	1	9	6	0	0.667	1.000	1.000
587	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREB1(1), CREBBP(9), EP300(5), NCOA3(5), PRKACG(1), PRKAR1A(2), RXRA(1)	15875670	24	15	24	10	7	4	1	8	4	0	0.749	1.000	1.000
588	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(2), DHCR24(2), DHCR7(3), FDFT1(1), FDPS(1), GGCX(1), GGPS1(1), HSD17B7(2), IDI1(2), LSS(1), MVD(3), NQO1(1), NSDHL(2), SQLE(1)	14744773	24	14	23	11	7	3	5	6	3	0	0.804	1.000	1.000
589	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(2), GOSR2(1), SNAP29(1), STX11(2), STX16(1), TSNARE1(3), USE1(2), VAMP4(1), VAMP5(2), VAMP8(1), VTI1A(2)	12786465	18	14	17	10	9	3	3	1	2	0	0.806	1.000	1.000
590	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(1), GNA13(2), MYL2(2), MYLK(5), PLCB1(3), PRKCA(5), ROCK1(2)	15823461	22	14	22	12	8	3	4	5	1	1	0.825	1.000	1.000
591	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(3), PFKP(1), PGD(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RBKS(1), RPIA(1), TAL1(1), TALDO1(2), TKT(2)	15660777	26	14	26	11	10	7	0	3	6	0	0.420	1.000	1.000
592	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), FUT1(1), FUT2(2), FUT5(3), FUT6(2), ST3GAL6(3), ST8SIA1(1)	12429865	21	13	21	12	6	2	2	6	5	0	0.933	1.000	1.000
593	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(6), PRKCA(5), PTK2B(2)	5169165	15	13	14	10	4	3	2	4	1	1	0.904	1.000	1.000
594	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(2), ALOX5(2), ALOX5AP(1), GGT1(2), LTA4H(4), PLA2G6(2), PTGES(1), PTGS1(2), PTGS2(2), TBXAS1(2)	11525165	21	12	21	11	6	6	2	3	4	0	0.815	1.000	1.000
595	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2)	10160354	26	12	26	11	9	2	3	10	2	0	0.697	1.000	1.000
596	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), JAK1(1), JAK2(4), JAK3(3), STAT1(2), STAT3(2), STAT5A(1), STAT5B(2), TYK2(7)	14110842	23	12	23	10	6	0	2	10	4	1	0.814	1.000	1.000
597	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ECHS1(2), EHHADH(1), HADHA(2), SDS(1)	9319021	20	12	20	11	8	2	3	3	4	0	0.782	1.000	1.000
598	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), DHFR(1), HPRT1(1), IMPDH1(4), OAZ1(1), POLB(3), POLD1(2), POLG(1), PRPS2(3), RRM1(3), SRM(2)	9538000	25	12	25	11	8	5	5	4	3	0	0.603	1.000	1.000
599	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ACAD9(1), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(1), ESCO2(2), PNPLA3(1), SH3GLB1(3)	19156495	26	11	25	10	6	5	2	12	1	0	0.722	1.000	1.000
600	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(3), ELOVL2(1), ELOVL6(1), FADS2(2), FASN(3), HADHA(2), PECR(2), SCD(1)	10969552	17	11	17	15	3	3	2	7	2	0	0.990	1.000	1.000
601	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7)	8255909	14	11	14	10	6	4	0	3	1	0	0.901	1.000	1.000
602	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7)	8661183	15	11	15	10	6	4	0	4	1	0	0.889	1.000	1.000
603	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(5)	12761359	22	10	22	13	7	4	2	8	1	0	0.924	1.000	1.000
604	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	16	CBS(4), CTH(1), DNMT1(3), DNMT3B(4), MARS(5), MARS2(2), MTFMT(1), MTR(2), SRM(2), TAT(1)	14490960	25	10	25	11	6	6	1	8	2	2	0.672	1.000	1.000
605	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(1), FYN(1), RELN(13), VLDLR(2)	10751396	17	9	17	11	6	6	1	3	1	0	0.871	1.000	1.000
606	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), NR3C1(3), PPARG(2), RXRA(1), TNF(1)	4459925	9	8	9	5	1	3	1	4	0	0	0.750	1.000	1.000
607	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(1), CNR2(2), DNMT1(3), MTNR1A(2), MTNR1B(1), PTAFR(1), PTGER4(1), PTGFR(6), TBXA2R(1)	8544506	19	7	19	10	6	3	0	9	1	0	0.808	1.000	1.000
608	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(1), UBE2G2(1), UBE2L6(1), UBE2M(1), UBE3A(1)	8076040	7	7	7	10	4	0	1	1	1	0	0.998	1.000	1.000
609	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2)	4328451	10	5	10	6	1	1	1	7	0	0	0.910	1.000	1.000
610	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(2), EIF2S2(1), PPP1CA(1)	8859236	6	4	6	7	1	1	2	2	0	0	0.987	1.000	1.000
611	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(2), P2RY6(2)	4580294	8	3	8	6	4	2	0	2	0	0	0.902	1.000	1.000
612	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1)	4665225	2	2	2	3	0	0	2	0	0	0	0.968	1.000	1.000
613	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		551919	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		391016	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		1174657	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		1314699	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
