rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), HSPA1A(1), IFNGR1(2), IFNGR2(17), IKBKB(4), JAK2(2), LIN7A(1), NFKBIA(2), RB1(3), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TP53(119), USH1C(1)	5180987	159	125	110	11	34	15	22	22	66	0	1.95e-07	<1.00e-15	<1.57e-13
2	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(3), DAXX(6), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(5), TNFRSF1A(2), TNFRSF1B(1), TP53(119)	5380911	143	120	108	10	35	15	20	23	50	0	3.70e-08	<1.00e-15	<1.57e-13
3	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(3), ATM(11), CCNE1(1), CDK4(2), MDM2(2), PCNA(1), RB1(3), TP53(119)	5074342	142	124	109	4	34	16	21	23	48	0	7.00e-11	1.44e-15	1.57e-13
4	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(7), AKT1(3), ATM(11), CSNK1A1(1), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), HSPA1A(1), MAPK8(2), MDM2(2), NFKBIB(1), NQO1(2), TP53(119)	5853817	154	127	119	10	35	16	22	28	53	0	1.45e-08	2.00e-15	1.57e-13
5	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(11), ATR(10), BRCA1(6), CDC25A(6), CDC25B(2), CDC25C(3), CDC34(1), CHEK2(1), EP300(6), MDM2(2), MYT1(12), PRKDC(9), RPS6KA1(2), TP53(119), YWHAH(1)	11825926	191	134	149	12	42	21	26	32	70	0	6.30e-09	2.33e-15	1.57e-13
6	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(7), ATM(11), ATR(10), CCNA1(3), CCNE1(1), CDC25A(6), CDK4(2), CDK6(2), CDKN2A(43), DHFR(1), GSK3B(2), RB1(3), SKP2(3), TFDP1(1), TGFB1(1), TGFB2(2), TP53(119)	8450927	217	133	160	15	36	26	29	28	98	0	6.52e-09	2.33e-15	1.57e-13
7	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), CDC42(1), DUSP10(1), DUSP8(1), GCK(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K7(12), MAP3K9(4), MAPK10(1), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(2), TP53(119), TRAF6(1), ZAK(5)	14186800	193	133	147	17	48	20	25	28	72	0	1.11e-07	2.66e-15	1.57e-13
8	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MAX(1), MYC(2), SP1(1), SP3(1), TP53(119)	1961934	124	120	91	0	30	12	15	19	48	0	6.00e-15	2.66e-15	1.57e-13
9	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), EGFR(2), IGF1R(6), MYC(2), POLR2A(6), PPP2CA(1), RB1(3), TEP1(18), TERF1(9), TERT(6), TNKS(4), TP53(119), XRCC5(2)	7893165	181	130	132	14	47	18	19	26	70	1	1.52e-08	2.78e-15	1.57e-13
10	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(7), CDKN2A(43), MDM2(2), MYC(2), PIK3CA(6), PIK3R1(2), POLR1A(6), POLR1B(3), RB1(3), TBX2(2), TP53(119)	5728217	195	131	143	5	36	23	23	25	88	0	6.55e-15	2.89e-15	1.57e-13
11	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(11), ATR(10), BRCA1(6), BRCA2(14), CHEK2(1), FANCA(5), FANCC(2), FANCD2(8), FANCG(1), HUS1(1), MRE11A(4), RAD17(9), RAD50(1), TP53(119), TREX1(2)	12196925	194	138	146	13	37	24	25	36	72	0	7.95e-08	3.33e-15	1.57e-13
12	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(3), BAK1(1), BCL2L1(7), BIRC2(2), CASP2(3), CASP7(2), CASP8(2), CASP9(1), FAS(3), FASLG(1), MAP2K4(5), MAP3K1(3), MAPK10(1), MDM2(2), MYC(2), NFKBIA(2), PARP1(8), PRF1(8), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TP53(119), TRADD(1), TRAF2(1)	10546582	183	131	135	14	39	17	27	25	74	1	7.01e-08	3.33e-15	1.57e-13
13	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(11), ATR(10), CDC25C(3), CHEK2(1), TP53(119), YWHAH(1)	4422649	145	127	110	4	32	14	20	23	56	0	1.44e-08	3.89e-15	1.57e-13
14	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(2), ARF3(1), CDK4(2), CDKN2A(43), MDM2(2), NXT1(1), PRB1(1), TP53(119)	2387559	171	125	120	2	35	17	19	21	79	0	1.22e-15	4.00e-15	1.57e-13
15	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(11), CDC25A(6), CDC25B(2), CDC25C(3), CDK4(2), MYT1(12), RB1(3), TP53(119), YWHAH(1)	4894440	159	127	120	5	38	16	22	25	58	0	2.21e-10	4.11e-15	1.57e-13
16	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(3), ATM(11), BAD(1), BCL2L1(7), CASP7(2), CASP9(1), PTK2(3), PXN(1), STAT1(3), TLN1(11), TP53(119)	7664270	165	129	125	8	40	21	20	26	58	0	2.70e-10	4.22e-15	1.57e-13
17	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(2), NFKBIA(2), RELA(3), TP53(119)	2806342	127	120	94	2	30	13	16	21	47	0	4.10e-11	4.33e-15	1.57e-13
18	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(7), ATM(11), BRCA1(6), CHEK2(1), MAPK8(2), MDM2(2), MRE11A(4), NFKBIA(2), RAD50(1), RBBP8(13), RELA(3), TP53(119), TP73(1)	8316212	172	134	126	4	37	18	24	24	69	0	8.87e-12	4.88e-15	1.67e-13
19	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), CDKN2A(43), E2F4(3), PRB1(1)	2559686	57	44	39	4	3	8	7	5	34	0	0.00661	2.41e-12	7.82e-11
20	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(3), BAD(1), BAK1(1), BCL2L1(7), BIRC2(2), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FAS(3), FASLG(1), HELLS(1), IKBKB(4), IRF1(2), IRF2(1), IRF3(1), IRF5(1), IRF6(4), IRF7(2), MAP2K4(5), MAP3K1(3), MAPK10(1), MDM2(2), MYC(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), PRF1(8), RELA(3), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TP53(119), TP73(1), TRADD(1), TRAF2(1)	16269943	208	135	162	20	46	25	30	28	78	1	6.18e-08	1.03e-11	3.17e-10
21	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(2), AKT3(4), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD72(2), CD81(2), CHUK(1), CR2(10), FCGR2B(2), GSK3B(2), HRAS(1), IFITM1(1), IKBKB(4), INPP5D(1), KRAS(142), LILRB3(3), LYN(1), MALT1(3), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG2(7), PPP3CA(3), PPP3CC(2), PTPN6(4), RAC2(1), RASGRP3(2), SYK(2), VAV1(6)	20892824	302	155	125	35	33	92	86	26	64	1	9.50e-12	1.45e-07	4.25e-06
22	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(3), CCND2(3), CCND3(1), CCNE1(1), CDC25A(6), CDK4(2), CDK6(2), CDK7(1), CDKN2A(43), RB1(3), RBL1(1), TFDP1(1)	4539373	67	50	45	7	2	10	8	6	41	0	0.0315	1.65e-07	4.61e-06
23	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(7), ATM(11), BUB1(2), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(4), CDC14B(1), CDC20(1), CDC25A(6), CDC25B(2), CDC25C(3), CDC6(3), CDC7(1), CDH1(1), CDK4(2), CDKN2A(43), CHEK2(1), E2F3(3), E2F4(3), E2F5(3), EP300(6), ESPL1(8), GSK3B(2), HDAC4(4), HDAC5(2), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), MPEG1(2), PCNA(1), PRKDC(9), PTPRA(1), RB1(3), RBL1(1), SKP2(3), SMAD4(41), TBC1D8(3), TFDP1(1), TGFB1(1), TP53(119)	31010499	352	148	288	27	77	42	49	51	132	1	8.88e-15	4.78e-07	1.28e-05
24	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(30), RANGAP1(4)	2331646	35	24	15	2	2	3	3	16	10	1	0.0169	1.04e-06	2.67e-05
25	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(2), ARPC2(1), CDC42(1), PAK1(19), PDGFRA(3), PIK3CA(6), PIK3R1(2), WASL(6)	3697475	40	34	20	2	4	5	2	4	25	0	0.0809	4.01e-06	9.88e-05
26	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(23), CRY1(1), CRY2(1), CSNK1E(1), PER1(5)	2422329	32	26	12	1	2	1	0	3	25	1	0.205	1.06e-05	0.000252
27	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), COASY(2), DPYD(4), DPYS(21), ENPP3(3), PANK1(1), PANK2(12), PANK3(1), PANK4(2), PPCS(1), UPB1(2)	3932523	51	39	23	4	5	7	3	4	32	0	0.105	2.61e-05	0.000596
28	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(5), CDK5R1(1), EGR1(23), HRAS(1), KLK2(1), NGFR(1)	2334760	32	26	12	4	3	0	3	2	24	0	0.813	8.70e-05	0.00191
29	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(2), AKT1(3), AKT2(2), AKT3(4), APAF1(3), ATM(11), BAD(1), BCL2L1(7), BIRC2(2), CAPN1(1), CAPN2(1), CASP10(2), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CSF2RB(2), DFFB(1), FAS(3), FASLG(1), IKBKB(4), IL1B(1), IL1RAP(2), IL3RA(3), IRAK3(2), IRAK4(1), NFKB2(1), NFKBIA(2), NTRK1(3), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RELA(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TP53(119), TRADD(1), TRAF2(1)	23631484	245	143	200	25	67	34	29	35	80	0	7.68e-10	0.000146	0.00309
30	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(18), CAPN1(1), CAPNS1(3), CAPNS2(2), CDK5(5), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(2), MAPT(3), PPP2CA(1)	2662891	38	29	21	5	7	6	1	2	22	0	0.251	0.000176	0.00361
31	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(2), AKT3(4), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), KRAS(142), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NOS3(9), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PRKCG(2), PTGS2(1), PTK2(3), PXN(1), RAC2(1), SH2D2A(6), SHC2(2), SPHK1(1), SPHK2(1), SRC(2)	20432635	287	154	111	36	33	86	90	25	53	0	1.38e-10	0.000196	0.00389
32	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), BAD(1), HRAS(1), IGF1R(6), IRS1(30), PIK3CA(6), PIK3R1(2), SHC1(2), SOS1(14), YWHAH(1)	5246771	66	50	31	9	8	5	3	6	44	0	0.516	0.000217	0.00417
33	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(11), HLA-DRB1(1)	837187	12	12	2	1	0	0	0	0	11	1	1.000	0.000236	0.00440
34	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(2), AKT3(4), BTK(1), FCER1A(1), FCER1G(1), FYN(9), GAB2(2), HRAS(1), INPP5D(1), KRAS(142), LYN(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(7), PRKCD(11), PRKCE(1), RAC2(1), SOS1(14), SOS2(1), SYK(2), VAV1(6)	20272827	268	153	101	35	24	81	86	22	54	1	4.12e-09	0.000275	0.00498
35	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA3(5), LTB4R(7), P2RY1(7), P2RY2(1), P2RY6(1)	1664827	22	17	18	1	7	6	3	2	4	0	0.00160	0.000349	0.00602
36	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(4), CPEB1(2), EGFR(2), ERBB2(6), ERBB4(6), ETS1(3), ETS2(2), ETV6(3), ETV7(1), FMN2(14), KRAS(142), NOTCH1(10), NOTCH2(4), NOTCH3(7), NOTCH4(5), PIWIL1(1), PIWIL2(3), PIWIL3(3), PIWIL4(1), SOS1(14), SOS2(1)	14836946	234	145	80	42	24	73	89	20	28	0	9.07e-05	0.000352	0.00602
37	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(2), COASY(2), DPYD(4), DPYS(21), ENPP3(3), ILVBL(2), PANK1(1), PANK2(12), PANK3(1), PANK4(2), PPCDC(1), PPCS(1), UPB1(2), VNN1(1)	4874218	57	41	29	4	9	8	4	4	32	0	0.0239	0.000450	0.00749
38	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ARPC1A(2), ARPC2(1), NCK1(3), NCKAP1(4), NTRK1(3), PIR(2), WASF1(1), WASF2(2), WASF3(24), WASL(6)	4258537	52	34	29	6	10	6	3	4	28	1	0.228	0.000527	0.00854
39	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC3B(2), APOBEC3G(1), APOBEC4(15)	2024717	23	19	9	1	3	2	2	1	15	0	0.238	0.000716	0.0113
40	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), HRAS(1), INSR(4), IRS1(30), MAPK8(2), PIK3CA(6), PIK3R1(2), RASA1(4), SHC1(2), SOS1(14), SRF(1)	7125134	69	52	35	8	8	5	2	7	47	0	0.288	0.000762	0.0117
41	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), HRAS(1), IGF1R(6), IRS1(30), MAPK8(2), PIK3CA(6), PIK3R1(2), RASA1(4), SHC1(2), SOS1(14), SRF(1)	6915590	71	54	37	9	8	5	3	7	48	0	0.325	0.000955	0.0144
42	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(3), ATM(11), ATR(10), BAI1(5), CASP8(2), CASP9(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(1), CCNG2(2), CDK4(2), CDK6(2), CDKN2A(43), CHEK2(1), DDB2(1), EI24(1), FAS(3), GTSE1(2), MDM2(2), PERP(1), PTEN(2), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN1(1), SESN2(3), SESN3(2), STEAP3(3), THBS1(7), TNFRSF10B(2), TP53(119), TP73(1), TSC2(8), ZMAT3(2)	18468358	258	137	202	30	63	37	32	30	96	0	1.67e-08	0.00168	0.0246
43	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(2), BRAF(4), FAS(3), FASLG(1), FCER1G(1), FYN(9), HLA-A(7), HLA-G(3), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNGR2(17), ITGAL(3), ITGB2(1), KIR2DL3(2), KIR3DL1(3), KLRC3(2), KRAS(142), LCK(1), NCR1(1), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PAK1(19), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG1(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PRF1(8), PRKCG(2), PTPN6(4), RAC2(1), SHC1(2), SHC2(2), SHC4(2), SOS1(14), SOS2(1), SYK(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(6), ZAP70(6)	31925138	379	161	149	47	42	90	89	31	126	1	5.16e-09	0.00541	0.0770
44	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(1), IKBKB(4), MAP3K1(3), MAP3K5(2), MAP4K5(1), MAPK8(2), NFKBIA(2), RELA(3), TNFRSF9(7), TNFSF9(28), TRAF2(1)	5499808	54	40	24	7	2	3	5	4	40	0	0.747	0.00550	0.0770
45	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(17), JAK1(1), JAK2(2), STAT1(3)	2267175	25	22	9	4	2	0	3	2	18	0	0.863	0.00701	0.0960
46	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(5), HLA-DRB1(1), IFNGR1(2), IFNGR2(17), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL2RA(1), IL4R(3)	3514311	34	29	16	4	5	1	2	2	24	0	0.419	0.00791	0.106
47	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(11), CD4(2), HLA-DRB1(1), IL1B(1), IL6(1)	1474496	16	13	6	2	0	0	1	1	13	1	0.839	0.0105	0.138
48	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(2), ACADM(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), CNDP1(2), DPYD(4), DPYS(21), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), HIBCH(10), UPB1(2)	7526227	68	48	42	5	14	6	9	5	33	1	0.00449	0.0115	0.147
49	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), HRAS(1), SHC1(2), SOS1(14), SRC(2)	2459819	21	18	10	2	2	3	0	1	15	0	0.432	0.0144	0.181
50	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(1), IL2RA(1), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), TOB1(8)	2958221	31	24	22	5	8	3	2	3	15	0	0.270	0.0188	0.232
51	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(23), CRY1(1), CRY2(1), CSNK1D(1), CSNK1E(1), NPAS2(4), PER1(5), PER2(5), PER3(2)	4811686	44	31	23	4	3	6	3	5	26	1	0.105	0.0277	0.332
52	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FSHB(1), FSHR(4), GNAS(16), XPO1(2)	2725058	28	19	19	2	16	2	4	4	2	0	0.0264	0.0281	0.332
53	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	HLA-A(7), KLRC3(2), KLRC4(1), PAK1(19), PIK3CA(6), PIK3R1(2), PTPN6(4), SYK(2), VAV1(6)	5177912	49	34	30	9	7	4	5	8	24	1	0.480	0.0462	0.537
54	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(16), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	2226947	23	17	10	2	3	0	4	1	15	0	0.496	0.0626	0.714
55	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(7), ABL2(2), AKT1(3), AKT2(2), AKT3(4), ARAF(2), BAD(1), BRAF(4), BTC(1), CAMK2D(1), CBL(5), CBLB(2), CBLC(1), CRK(1), CRKL(2), EGF(4), EGFR(2), ELK1(2), ERBB2(6), ERBB3(6), ERBB4(6), GSK3B(2), HRAS(1), KRAS(142), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK9(1), MYC(2), NCK1(3), NCK2(2), NRG1(3), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), RPS6KB2(4), SHC1(2), SHC2(2), SHC4(2), SOS1(14), SOS2(1), SRC(2), STAT5A(2)	29038562	325	153	151	40	39	90	92	25	79	0	2.85e-10	0.0699	0.783
56	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(2), AKT3(4), CARD11(3), CBL(5), CBLB(2), CBLC(1), CD3E(1), CD4(2), CD8B(2), CDC42(1), CDK4(2), CHUK(1), FYN(9), GRAP2(2), HRAS(1), IKBKB(4), ITK(1), KRAS(142), LCK(1), MALT1(3), NCK1(3), NCK2(2), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKCQ(3), PTPN6(4), PTPRC(3), RASGRP1(2), RHOA(1), SOS1(14), SOS2(1), TEC(2), VAV1(6), ZAP70(6)	28494610	356	162	147	45	42	96	88	28	101	1	2.44e-09	0.0860	0.946
57	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), FADS2(15), PLA2G12B(1), PLA2G3(2), PLA2G6(4)	2847543	25	20	11	7	2	2	3	1	17	0	0.969	0.0942	1.000
58	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(5), GRIA2(1), JUND(1), PPP1R1B(1)	1078118	8	8	4	0	0	0	1	1	6	0	0.654	0.101	1.000
59	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(5), CDK5R1(1), CSNK1D(1), DRD1(5), GRM1(17), PLCB1(1), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	4473555	45	26	35	6	14	5	5	6	15	0	0.0491	0.112	1.000
60	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(4), NR3C1(2), PPARG(1), RETN(7), RXRA(1)	1605614	16	11	10	2	3	1	2	1	9	0	0.339	0.122	1.000
61	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(2), B3GNT7(1), B4GALT2(16), CHST1(1), CHST2(2), CHST4(1), CHST6(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	3531442	32	22	19	2	6	2	6	2	16	0	0.0463	0.147	1.000
62	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL6(1), FADS1(1), FADS2(15), FASN(7), HADHA(1), HSD17B12(1), SCD(12)	4158864	43	28	19	5	5	4	4	0	29	1	0.200	0.152	1.000
63	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(3), AOC3(3), CES1(2), ESD(5)	1669202	13	9	10	1	4	2	3	0	4	0	0.153	0.156	1.000
64	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(2), ACADL(2), ACADM(2), ACADSB(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), CNDP1(2), DPYD(4), DPYS(21), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), UPB1(2)	8076794	65	41	48	5	16	9	9	6	24	1	0.000713	0.173	1.000
65	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(5), CDK5R1(1), DAB1(2), FYN(9), LRP8(3), RELN(14), VLDLR(3)	3879364	37	27	21	8	7	4	3	2	20	1	0.710	0.179	1.000
66	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(11), CCNA1(3), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(6), CDK4(2), CDK7(1), CDKN2A(43), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(3), E2F5(3), GBA2(3), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), MYC(2), MYT1(12), NACA(13), PCNA(1), POLA2(1), POLE(8), POLE2(1), PRIM1(1), RB1(3), RBL1(1), RPA1(1), RPA2(3), RPA3(2), TFDP1(1), TFDP2(4), TNXB(13), TP53(119)	21868365	298	137	238	35	68	37	43	45	104	1	2.32e-09	0.209	1.000
67	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD17B7(11), HSD3B1(2)	2258366	22	14	13	4	1	15	2	3	1	0	0.0415	0.217	1.000
68	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(9), THBS1(7)	2045120	16	16	5	3	5	2	0	0	9	0	0.487	0.225	1.000
69	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(1), RAB9A(1)	1187560	12	6	12	1	5	3	2	1	1	0	0.0706	0.238	1.000
70	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(2), PAK1(19), PIK3CA(6), PIK3R1(2), RB1(3), RELA(3), TFDP1(1)	5667021	45	33	26	9	4	4	7	5	25	0	0.761	0.271	1.000
71	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), HRAS(1), KLK2(1), NTRK1(3), PIK3CA(6), PIK3R1(2), PLCG1(1), SHC1(2), SOS1(14)	4346793	33	25	21	5	6	4	2	4	17	0	0.362	0.274	1.000
72	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(4), EPHB1(2), FYN(9), ITGA1(7), L1CAM(6), LYN(1), RAP1B(3), SELP(3)	4354846	39	26	28	5	12	5	3	4	15	0	0.0513	0.279	1.000
73	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(16), GNB1(2), PRKAR1A(1)	1907431	24	16	15	3	15	4	2	2	1	0	0.0536	0.292	1.000
74	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(6), CDC25B(2), CDK7(1)	1988514	9	9	5	1	2	0	1	0	6	0	0.632	0.301	1.000
75	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(1), CFTR(5), GNAS(16), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SLC9A3R1(1)	3735255	37	23	28	4	20	6	4	5	2	0	0.00612	0.305	1.000
76	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD4(2), FYN(9), HLA-DRB1(1), LCK(1), PTPRC(3), ZAP70(6)	2540664	23	14	15	2	4	3	1	2	13	0	0.154	0.308	1.000
77	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(8), AGT(1), AGTR2(1), BDKRB2(1), KNG1(2), NOS3(9), REN(8)	2809457	30	17	22	3	7	2	9	1	11	0	0.0846	0.352	1.000
78	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(5), EGF(4), EGFR(2), HRAS(1), PTPRB(10), RASA1(4), SHC1(2), SOS1(14), SPRY4(5), SRC(2)	6948332	49	33	34	4	2	9	5	6	26	1	0.0640	0.378	1.000
79	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(2), ELK1(2), GNAS(16), GNB1(2), HRAS(1), IGF1R(6), KLK2(1), MKNK2(3), MYC(2), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(4), SHC1(2), SOS1(14), SRC(2), STAT3(2)	9379376	66	46	44	9	21	11	5	5	24	0	0.0168	0.382	1.000
80	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(3)	515787	3	3	3	0	1	0	0	2	0	0	0.448	0.386	1.000
81	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT1(3), AKT2(2), AKT3(4), BAD(1), BTK(1), CDKN2A(43), DAPP1(2), GSK3A(2), GSK3B(2), IARS(4), INPP5D(1), PDK1(1), PIK3CA(6), PPP1R13B(1), PTEN(2), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS1(14), SOS2(1), TEC(2), YWHAE(3), YWHAH(1)	10138451	104	68	71	13	13	15	5	12	59	0	0.0145	0.387	1.000
82	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(1), FMOD(2), KERA(2), LUM(2)	1001919	7	4	7	1	1	0	1	4	1	0	0.478	0.397	1.000
83	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(6), CDC25B(2), CDC25C(3), CSK(1), PTPRA(1), SRC(2)	2561472	15	14	9	2	3	2	2	0	8	0	0.463	0.404	1.000
84	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), BAD(1), CHRNB1(4), CHRNG(2), MUSK(7), PIK3CA(6), PIK3R1(2), PTK2(3), SRC(2), TERT(6), YWHAH(1)	4647173	37	22	32	6	7	9	2	6	13	0	0.0599	0.420	1.000
85	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(2), UGP2(6), UXS1(2)	1375884	11	9	9	3	0	2	1	4	4	0	0.765	0.425	1.000
86	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(5), CREBBP(3), DFFB(1), HMGB2(1), NME1(1), PRF1(8), SET(1)	2974230	20	15	13	4	3	2	2	1	12	0	0.629	0.444	1.000
87	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(2), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3CA(6), PIK3R1(2), PLCG1(1), SHC1(2), SOS1(14)	5358541	33	24	22	3	4	5	2	4	18	0	0.0789	0.448	1.000
88	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(5), ADCY8(4), ARAF(2), ATF4(1), BRAF(4), CACNA1C(9), CALML3(1), CALML6(2), CAMK2D(1), CAMK4(2), CREBBP(3), EP300(6), GNAQ(1), GRIA1(3), GRIA2(1), GRIN1(8), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRM1(17), GRM5(7), HRAS(1), ITPR1(10), ITPR2(12), ITPR3(10), KRAS(142), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), RAP1B(3), RAPGEF3(4), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5)	28310183	319	157	162	50	53	85	99	28	52	2	1.17e-09	0.458	1.000
89	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3E(1), HLA-A(7), ICAM1(2), ITGAL(3), ITGB2(1), PRF1(8)	2416507	22	13	17	4	5	1	2	3	11	0	0.387	0.486	1.000
90	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(10), BMPR1A(4), BMPR2(3)	1735555	17	9	17	3	4	6	2	1	4	0	0.190	0.495	1.000
91	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(2), DFFB(1), HMGB1(6), HMGB2(1), TOP2A(2), TOP2B(6)	2673016	18	14	15	3	3	3	2	6	4	0	0.368	0.513	1.000
92	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(2), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALT2(16), FUT1(1), FUT2(3), FUT3(1), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GCNT2(1), ST8SIA1(2)	4597218	35	23	22	3	10	4	4	0	17	0	0.0479	0.518	1.000
93	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(3), NR4A3(12), WDR1(2)	3080685	25	14	15	6	5	2	1	5	12	0	0.606	0.528	1.000
94	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(6), CASP1(4), CASP10(2), CASP8(2), CASP9(1), PRF1(8)	3574525	26	17	21	5	4	4	1	3	13	1	0.475	0.537	1.000
95	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(1)	1070904	3	3	3	0	1	1	1	0	0	0	0.341	0.540	1.000
96	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(6), CDC25B(2), CDC25C(3), CDK7(1), XPO1(2)	2433002	14	12	8	2	3	0	1	0	10	0	0.635	0.543	1.000
97	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(7), ANAPC1(3), ANAPC2(4), ANAPC4(3), ANAPC5(6), ANAPC7(1), ATM(11), ATR(10), BUB1(2), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(4), CDC14B(1), CDC16(1), CDC20(1), CDC23(2), CDC25A(6), CDC25B(2), CDC25C(3), CDC27(8), CDC6(3), CDC7(1), CDK4(2), CDK6(2), CDK7(1), CDKN2A(43), CHEK2(1), CREBBP(3), CUL1(4), E2F3(3), EP300(6), ESPL1(8), GSK3B(2), MAD1L1(1), MAD2L1(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), PCNA(1), PKMYT1(2), PRKDC(9), RB1(3), RBL1(1), RBL2(2), SKP1(1), SKP2(3), SMAD2(1), SMAD3(1), SMAD4(41), SMC1A(1), SMC1B(5), TFDP1(1), TGFB1(1), TGFB2(2), TP53(119), YWHAE(3), YWHAH(1)	38274387	395	157	327	39	83	54	58	52	147	1	1.26e-12	0.545	1.000
98	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(16), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	2773813	28	16	19	3	19	4	3	2	0	0	0.0175	0.546	1.000
99	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(11), CDC25A(6), CDC25B(2), CDC25C(3), MYT1(12), YWHAH(1)	3821993	35	20	29	5	8	4	5	5	13	0	0.188	0.550	1.000
100	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IL12B(1)	830479	5	5	4	2	0	2	0	0	3	0	0.927	0.553	1.000
101	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ARPC1A(2), ARPC2(1), CDC42(1), WASF1(1), WASL(6)	2248368	15	10	13	3	3	4	2	2	4	0	0.382	0.559	1.000
102	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(2)	554983	2	2	2	0	1	1	0	0	0	0	0.477	0.560	1.000
103	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(7), ABCB11(4), ABCB4(9), ABCC1(1), ABCC3(5), GSTP1(1)	3982139	27	20	18	4	6	4	3	5	9	0	0.147	0.565	1.000
104	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(3)	454101	4	2	4	0	2	1	0	1	0	0	0.236	0.567	1.000
105	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(8), CDH1(1), CREBBP(3), EP300(6), MAP3K7(12), SKIL(1), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10)	7128531	52	33	41	8	13	5	8	7	19	0	0.122	0.568	1.000
106	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(2), IL6(1), LDLR(1), LPL(4)	1469397	10	5	10	0	3	3	1	1	2	0	0.0233	0.578	1.000
107	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(2), ILK(1), PDK2(3), PIK3CA(6), PIK3R1(2), PTEN(2), PTK2(3), SHC1(2), SOS1(14)	5443687	38	24	26	4	6	6	4	4	18	0	0.0858	0.585	1.000
108	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(4), F5(14), FGA(6), FGB(4), FGG(2), PROC(1), PROS1(2), SERPINC1(3), TFPI(2)	4545514	38	19	33	9	3	7	15	10	3	0	0.293	0.587	1.000
109	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(3), CPS1(5), GLS(1), GOT1(3)	2162834	13	6	12	0	4	2	3	3	0	1	0.0265	0.595	1.000
110	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(4)	895970	5	4	5	1	4	0	0	0	1	0	0.411	0.610	1.000
111	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(4), CSAD(1), GAD1(6), GAD2(5), GGT1(1)	1618869	18	11	15	7	4	3	4	1	5	1	0.763	0.617	1.000
112	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(3), ANXA1(3), GNAS(16), GNB1(2), NOS3(9), NR3C1(2), PIK3CA(6), PIK3R1(2), RELA(3), SYT1(1)	5102734	48	29	38	7	18	5	11	7	7	0	0.0494	0.638	1.000
113	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(9), MMP2(2), MMP9(4), RECK(3)	2107969	19	11	12	6	5	3	2	0	9	0	0.654	0.638	1.000
114	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(2), AKT3(4), ELK1(2), HRAS(1), NGFR(1), NTRK1(3), PIK3CA(6), PIK3CD(2), SHC1(2), SOS1(14)	4622429	40	29	27	9	10	3	2	5	20	0	0.466	0.656	1.000
115	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1)	315467	1	1	1	0	0	0	0	0	1	0	0.842	0.669	1.000
116	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	619349	3	2	3	2	0	0	0	1	2	0	0.934	0.701	1.000
117	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), CSF3(2), EPO(2), IL6(1), IL7(1), IL9(1)	1719135	11	5	10	1	1	1	2	4	3	0	0.291	0.703	1.000
118	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	199171	2	1	2	1	2	0	0	0	0	0	0.802	0.711	1.000
119	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11A1(2), CYP11B1(7), CYP11B2(6), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2)	2675545	21	17	16	5	6	4	2	2	7	0	0.388	0.716	1.000
120	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11A1(2), CYP11B1(7), CYP11B2(6), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2)	2675545	21	17	16	5	6	4	2	2	7	0	0.388	0.716	1.000
121	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(5), AKT1(3), BAD(1), BCL2L1(7), CSF2RB(2), IGF1R(6), IL3RA(3), KIT(4), PIK3CA(6), PIK3R1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), YWHAH(1)	6119091	49	26	42	8	15	7	5	8	14	0	0.0253	0.723	1.000
122	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), NTAN1(5), SIRT1(1), SIRT2(1)	3298271	14	10	11	0	4	1	1	2	6	0	0.0506	0.726	1.000
123	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(5), UBE2F(1), UBE2G2(1)	1776018	10	5	10	1	4	1	3	1	1	0	0.127	0.743	1.000
124	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAK1(1), BFAR(2), BTK(1), CAD(6), CASP10(2), CASP8(2), CSNK1A1(1), DAXX(6), DEDD(2), EGFR(2), EPHB2(4), FAF1(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MET(4), NFAT5(31), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PTPN13(8), RALBP1(2), ROCK1(6), SMPD1(1), TP53(119), TPX2(2), TRAF2(1)	20793911	234	138	172	31	49	32	32	32	89	0	1.61e-05	0.747	1.000
125	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), ATIC(2), DHFR(1), FTCD(2), GART(1), MTFMT(4), MTHFD1(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(2), SHMT2(4), TYMS(1)	5281751	33	16	28	7	5	4	5	5	13	1	0.213	0.764	1.000
126	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1R(9)	1818711	12	9	10	3	2	3	0	2	5	0	0.431	0.766	1.000
127	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), ESCO1(3), ESCO2(12), SH3GLB1(1)	4600520	22	17	11	4	2	2	1	3	14	0	0.718	0.770	1.000
128	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), TAT(1)	726398	4	2	4	1	0	1	2	1	0	0	0.677	0.777	1.000
129	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), FUT2(3), FUT3(1), ST3GAL4(2)	2012061	11	8	11	2	8	0	0	2	1	0	0.256	0.783	1.000
130	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(2), ACADS(1), ACAT1(2), HADHA(1)	1510553	8	4	8	0	1	4	1	1	1	0	0.0836	0.786	1.000
131	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(4), PSMB1(1), PSMB10(1), PSMB4(6), PSMB5(2), PSMB6(1)	2422803	19	15	16	6	6	0	2	2	9	0	0.727	0.789	1.000
132	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(2), BRAF(4), CACNA1A(9), CRHR1(2), GNA11(3), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(16), GNAZ(1), GRIA1(3), GRIA2(1), GRID2(10), GRM1(17), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HRAS(1), IGF1R(6), ITPR1(10), ITPR2(12), ITPR3(10), KRAS(142), LYN(1), NOS1(10), NOS3(9), NPR1(5), NPR2(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PRKCG(2), PRKG1(1), PRKG2(2), RYR1(24)	31226969	360	162	199	52	90	81	114	35	40	0	3.08e-12	0.791	1.000
133	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(2), TPI1(3)	1074702	6	3	6	1	3	2	0	1	0	0	0.295	0.792	1.000
134	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(2), ST6GALNAC5(25), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3)	4584426	55	39	31	13	10	5	7	2	31	0	0.510	0.799	1.000
135	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(3), EP300(6), IKBKB(4), IL1B(1), MAP2K3(1), MAP2K6(3), MAP3K7(12), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(3), TGFBR1(8), TGFBR2(10), TLR2(2)	8346272	59	34	49	8	14	8	10	6	21	0	0.0208	0.802	1.000
136	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(11), CCND2(3), CDK4(2), EGR1(23), ESR2(3), FSHR(4), GJA4(2), LHCGR(2), MLH1(1), NCOR1(9), NRIP1(1), PGR(4), PRLR(2), SMPD1(1), ZP2(1)	9796804	69	39	53	9	13	6	14	10	26	0	0.0438	0.803	1.000
137	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(6), CYP17A1(1), HSD11B1(1), HSD3B1(2)	1918022	14	10	11	4	2	3	3	2	4	0	0.527	0.806	1.000
138	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(4), PSMB1(1), PSMB4(6), PSMB5(2), PSMB6(1), UBE3A(6)	3595993	24	17	20	5	8	1	2	3	10	0	0.401	0.811	1.000
139	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2), HLA-DRB1(1)	659834	3	2	3	1	0	0	0	1	2	0	0.905	0.813	1.000
140	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(2), BDH2(1), HMGCS2(1), OXCT1(2), OXCT2(1)	2017978	9	5	9	1	1	5	0	1	2	0	0.148	0.816	1.000
141	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNAQ(1), GNB1(2), HTR2C(5), PLCB1(1), TUB(2)	1981498	12	8	12	4	4	3	0	4	1	0	0.505	0.820	1.000
142	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(1), GHR(1), HRAS(1), IGF1R(6), PIK3CA(6), PIK3R1(2), SHC1(2)	3702073	22	15	21	4	6	3	3	4	6	0	0.161	0.821	1.000
143	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), HRAS(1), JAK2(2), PIK3CA(6), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SOS1(14), STAT1(3), STAT3(2), STAT5A(2), THPO(1)	8338252	41	28	30	6	5	6	3	5	22	0	0.299	0.829	1.000
144	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADH(1), HADHA(1), HADHB(2), HSD17B4(3), MECR(2), PPT1(1), PPT2(3)	2366220	13	6	13	0	3	3	1	2	4	0	0.0205	0.830	1.000
145	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(3)	1273098	4	3	4	2	2	1	1	0	0	0	0.786	0.843	1.000
146	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(5), ADRB2(1), GNAS(16), PLCE1(6), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RAP2B(2)	4250619	39	22	30	5	21	3	5	7	3	0	0.0195	0.846	1.000
147	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), HRAS(1), IL3RA(3), JAK2(2), PTPN6(4), SHC1(2), SOS1(14), STAT5A(2)	4937040	30	20	19	7	7	2	3	3	15	0	0.696	0.847	1.000
148	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(1), DHCR7(1), FDFT1(2), FDPS(1), GGCX(2), HMGCR(7), HSD17B7(11), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(2), NSDHL(2), SQLE(2), VKORC1(3)	5437667	42	26	31	8	11	16	8	2	5	0	0.0186	0.851	1.000
149	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3)	3500482	31	14	31	6	7	7	5	5	7	0	0.104	0.852	1.000
150	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(3), NDUFV2(3)	1948449	13	8	11	3	3	5	0	2	3	0	0.432	0.853	1.000
151	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLS(1), OAT(2), PRODH(2)	1579580	9	4	9	1	3	1	2	1	2	0	0.224	0.854	1.000
152	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR161(2), GPR171(2), GPR18(2), GPR34(1), GPR39(4), GPR65(3), GPR75(1)	2740159	16	11	16	4	2	5	1	4	4	0	0.340	0.854	1.000
153	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPT(2), ENPP3(3), FLAD1(5), RFK(1), TYR(4)	2699666	16	9	13	2	5	3	2	1	5	0	0.261	0.856	1.000
154	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(1), HADHA(1)	1347131	3	3	3	1	1	0	1	0	1	0	0.656	0.858	1.000
155	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(3), NR1H4(1), RXRA(1)	1506654	6	4	6	1	2	3	1	0	0	0	0.194	0.860	1.000
156	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(5), CDC25C(3), GNAI1(1), GNAS(16), GNB1(2), HRAS(1), MYT1(12), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RPS6KA1(2), SRC(2)	5832264	57	29	45	9	26	11	6	7	7	0	0.00738	0.865	1.000
157	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(1), CD3E(1), CD4(2), CD58(2), CSF3(2), IL6(1)	1737423	11	4	10	1	1	1	1	3	5	0	0.264	0.867	1.000
158	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAD(1), BAK1(1), BCL2L1(7), CASP9(1), CES1(2)	3149463	15	9	9	3	2	3	3	0	7	0	0.694	0.867	1.000
159	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	3608520	19	12	19	3	12	1	3	1	2	0	0.0811	0.869	1.000
160	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), AFMID(2), GRHPR(6), HAO1(1), HAO2(1), MDH2(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1)	3705075	18	11	13	1	3	3	1	0	11	0	0.127	0.873	1.000
161	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(4), AGT(1), AGTR2(1), CMA1(1), COL4A1(5), COL4A2(6), COL4A3(2), COL4A4(13), COL4A5(5), COL4A6(6), REN(8)	7073773	52	29	40	6	7	8	15	2	19	1	0.108	0.880	1.000
162	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO3(1), FARS2(2), GOT1(3), PAH(1), TAT(1)	2284627	11	7	10	2	3	2	4	2	0	0	0.335	0.883	1.000
163	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(1), CD80(1), CD86(5), HLA-DRB1(1), ITK(1), LCK(1), PIK3CA(6), PIK3R1(2)	3530838	18	13	16	4	5	2	2	3	6	0	0.327	0.885	1.000
164	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP1(2), ARFGAP3(9), ARFGEF2(3), CLTB(1), COPA(6), GBF1(3), GPLD1(2), KDELR2(1)	4497289	29	18	20	7	5	3	3	4	13	1	0.599	0.890	1.000
165	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(4), CAMP(2), CREB1(2), CREB5(1), SNX13(4), SRC(2), TERF2IP(1)	3154681	19	10	19	2	2	2	4	4	7	0	0.191	0.890	1.000
166	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3CA(6), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SOS1(14), SRF(1), STAT1(3), STAT3(2), STAT5A(2)	9740882	55	33	44	8	9	7	5	9	25	0	0.130	0.891	1.000
167	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(16), GNB1(2), PPP2CA(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	4368150	38	19	29	5	20	7	3	4	4	0	0.0111	0.892	1.000
168	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), OXCT1(2)	933559	4	2	4	0	0	3	0	0	1	0	0.324	0.894	1.000
169	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(3), UBE2D1(1), UBE2E1(1), UBE2E3(2), UBE2G2(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(6)	2939320	19	8	17	1	8	4	4	1	2	0	0.0121	0.897	1.000
170	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), GRHPR(6), HAO1(1), HAO2(1), MDH2(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1)	3535783	16	10	11	0	2	3	1	0	10	0	0.0660	0.900	1.000
171	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPO(2), EPOR(2), HRAS(1), JAK2(2), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(2), SOS1(14), STAT5A(2)	6054711	35	19	24	6	7	3	4	3	18	0	0.343	0.907	1.000
172	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(4), CSF1(2), IL1B(1), IL6R(1), SELL(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(2), TNFSF8(3)	3810223	28	15	23	9	6	1	5	5	11	0	0.698	0.909	1.000
173	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(2), AKT3(4), BPNT1(2), ILK(1), PDK1(1), PIK3CA(6), PIK3CD(2), PTEN(2), RBL2(2), SHC1(2), SOS1(14)	5692594	41	26	28	9	7	4	4	7	19	0	0.534	0.909	1.000
174	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(3), IDH2(5), OGDH(5), SDHA(6), SUCLA2(1)	2602372	20	10	19	5	3	3	5	6	3	0	0.402	0.910	1.000
175	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(6)	1835786	10	6	9	2	4	0	1	3	2	0	0.436	0.912	1.000
176	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(1), FUT2(3), FUT9(1), GCNT2(1), ST8SIA1(2)	1747926	8	4	8	1	6	1	1	0	0	0	0.134	0.914	1.000
177	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(2), ACADS(1), ACSL1(2), ACSL3(4), ACSL4(3), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1), SCP2(1)	4680162	19	10	19	1	5	4	4	2	4	0	0.0188	0.916	1.000
178	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(8), AXIN1(4), BTRC(2), CREBBP(3), CSNK1A1(1), CSNK1D(1), CSNK2A1(1), CTNNB1(9), DVL1(4), FZD1(5), GSK3B(2), MAP3K7(12), MYC(2), NLK(2), PPARD(2), PPP2CA(1), TLE1(3), WIF1(2), WNT1(1)	8376009	65	34	56	9	14	11	10	11	19	0	0.0192	0.917	1.000
179	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(2)	1563637	14	6	12	2	6	2	3	0	3	0	0.0911	0.917	1.000
180	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2)	4201480	24	15	20	4	3	5	6	1	9	0	0.270	0.920	1.000
181	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2)	4201480	24	15	20	4	3	5	6	1	9	0	0.270	0.920	1.000
182	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2)	4201480	24	15	20	4	3	5	6	1	9	0	0.270	0.920	1.000
183	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), ATIC(2), ATP6V0C(1), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(2), SHMT2(4), TYMS(1)	4968172	28	12	26	6	4	4	6	4	9	1	0.172	0.922	1.000
184	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), FH(3), IDH1(1), IDH2(5), MDH2(1), SUCLA2(1)	2458559	15	8	14	2	1	3	5	2	4	0	0.334	0.923	1.000
185	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1)	2228147	8	7	8	2	6	1	1	0	0	0	0.311	0.925	1.000
186	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1)	2228147	8	7	8	2	6	1	1	0	0	0	0.311	0.925	1.000
187	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRP9(1), SRPR(2)	2079787	12	4	12	0	3	4	3	1	1	0	0.0352	0.927	1.000
188	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(4), SPCS1(1)	859342	7	3	7	2	1	1	2	3	0	0	0.638	0.929	1.000
189	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(3), CPOX(3), HMBS(1), PPOX(2)	2123550	9	7	9	2	3	2	1	1	2	0	0.547	0.931	1.000
190	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(5), CR2(10), FCGR2B(2), HLA-DRB1(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3)	4215423	28	18	24	7	6	6	1	5	10	0	0.323	0.932	1.000
191	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3)	4908489	46	22	44	8	11	7	9	7	12	0	0.0419	0.933	1.000
192	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1)	4859222	27	17	22	4	3	4	5	6	9	0	0.266	0.935	1.000
193	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(2), CCR2(1), CCR3(11), CCR4(4), CCR7(1), CD4(2), CXCR4(3), IFNGR1(2), IFNGR2(17), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL4R(3), TGFB1(1), TGFB2(2)	5597321	55	39	28	11	5	4	4	4	37	1	0.854	0.937	1.000
194	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), CALML3(1), CALML6(2), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(3), CTNNB1(9), DCT(3), DVL1(4), DVL2(4), DVL3(2), EDN1(4), EDNRB(2), EP300(6), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(16), GSK3B(2), HRAS(1), KIT(4), KRAS(142), LEF1(3), MITF(3), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), POMC(1), PRKACB(1), PRKACG(3), PRKCG(2), TCF7(2), TCF7L1(4), TCF7L2(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(7), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1)	31132235	342	155	185	71	87	94	97	32	31	1	3.02e-09	0.940	1.000
195	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), CREB1(2), HRAS(1), MAPK7(4), MEF2A(2), MEF2C(2), MEF2D(2), NTRK1(3), PIK3CA(6), PIK3R1(2), PLCG1(1), RPS6KA1(2), SHC1(2)	5343108	32	20	30	4	7	7	5	3	10	0	0.0500	0.941	1.000
196	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(2), ERBB3(6), NRG1(3), UBE2D1(1)	2852820	16	7	16	2	1	4	5	3	3	0	0.195	0.941	1.000
197	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(4), FBXW7(6), RB1(3), TFDP1(1)	2336974	16	9	16	6	2	4	3	3	4	0	0.749	0.943	1.000
198	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF3(2), EPO(2), FLT3(4), IL6(1), IL9(1), TGFB1(1), TGFB2(2)	2336734	14	8	12	3	2	2	4	2	4	0	0.518	0.944	1.000
199	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(4), EGFR(2), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PIK3CA(6), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SOS1(14), SRF(1), STAT1(3), STAT3(2), STAT5A(2)	10445354	58	35	47	9	7	9	6	10	26	0	0.146	0.945	1.000
200	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(6), HDC(1), TH(1), TPH1(2)	1705181	11	5	11	5	3	0	3	1	3	1	0.702	0.946	1.000
201	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11)	4179890	32	18	24	5	4	7	8	11	2	0	0.0734	0.946	1.000
202	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(6), MEF2A(2), MEF2C(2), MEF2D(2), YWHAH(1)	2235400	16	7	16	2	3	3	7	1	2	0	0.126	0.948	1.000
203	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1), SQLE(2)	907943	6	4	5	3	2	2	1	0	1	0	0.727	0.949	1.000
204	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(3), FUT3(1), FUT5(1), FUT6(2)	1434162	8	5	8	2	5	2	0	0	1	0	0.284	0.950	1.000
205	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(4), LPO(6), MPO(2), TPO(7)	2349521	23	12	23	5	11	1	6	2	3	0	0.140	0.950	1.000
206	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), CD80(1), HLA-DRB1(1)	1100222	4	2	4	1	0	0	1	1	2	0	0.845	0.950	1.000
207	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2), CFLAR(3)	1072663	5	3	5	3	1	0	1	1	2	0	0.841	0.950	1.000
208	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), KEAP1(2), MAFF(2), MAPK8(2), NFE2L2(1)	2522256	9	5	9	1	2	0	1	3	3	0	0.315	0.951	1.000
209	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), TPO(7), TYR(4)	2706020	27	13	26	8	12	2	7	2	4	0	0.356	0.954	1.000
210	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(7), PRKACB(1), PRKACG(3), PRKAR2B(1)	2811189	12	7	12	4	2	3	2	2	3	0	0.702	0.954	1.000
211	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL1(1), FOSL2(3), IFNAR1(2), IFNAR2(1), MAPK8(2), RELA(3), TNFRSF11A(5), TRAF6(1)	3108588	18	9	17	5	1	3	3	5	6	0	0.638	0.955	1.000
212	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3E(1), CD4(2)	890226	3	1	3	1	0	0	0	1	2	0	0.839	0.957	1.000
213	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(3), TAT(1), TYR(4)	1296960	9	4	9	3	2	1	4	2	0	0	0.695	0.958	1.000
214	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), JUNB(1), MAF(2), MAP2K3(1), NFATC1(4), NFATC2(10), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1)	3489258	30	16	26	6	14	6	2	2	6	0	0.0228	0.958	1.000
215	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(3), GPI(3), HK1(3), PFKL(2), PGAM1(1), PGK1(3), PKLR(2), TPI1(3)	2596957	22	9	22	6	10	8	1	2	1	0	0.0956	0.958	1.000
216	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(18), GPRC5A(2), GPRC5B(5), GPRC5C(6), GRM1(17), GRM2(5), GRM3(3), GRM4(4), GRM5(7), GRM7(5), GRM8(5)	5821743	82	43	60	15	22	15	8	7	30	0	0.0360	0.959	1.000
217	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(2), CDO1(4), GOT1(3), LDHAL6B(2), LDHB(1), SULT1B1(4), SULT1C4(1), SULT4A1(1)	3517773	18	11	13	5	1	2	3	3	9	0	0.835	0.959	1.000
218	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3)	1552564	13	2	13	4	5	3	1	2	2	0	0.424	0.960	1.000
219	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(2), CREB1(2), EDN1(4), EP300(6), EPO(2), HIF1A(1), NOS3(9)	4761020	26	12	24	2	7	2	7	2	8	0	0.0431	0.961	1.000
220	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), BAD(1), CASP9(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(6), PIK3R1(2), PPP2CA(1), RELA(3), YWHAH(1)	3961219	22	14	21	5	2	4	5	4	7	0	0.425	0.961	1.000
221	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A2(2), EIF4G1(8), EIF4G2(1), EIF4G3(7), GHR(1), IRS1(30), PABPC1(16), PDK2(3), PIK3CA(6), PIK3R1(2), PTEN(2)	7820950	81	58	42	14	9	9	9	7	47	0	0.684	0.962	1.000
222	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(6), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), WBSCR17(2)	3980509	24	12	23	7	11	3	6	2	2	0	0.381	0.962	1.000
223	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), ATP6V0C(1), CAT(1), EPX(4), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), SHMT1(2), SHMT2(4), TPO(7)	3314319	33	14	32	7	11	8	8	1	5	0	0.0670	0.965	1.000
224	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(2), FDPS(1), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(2), NQO2(2), SQLE(2), VKORC1(3)	3149254	27	13	25	6	8	7	7	1	4	0	0.122	0.966	1.000
225	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPO(2), EPOR(2), GRIN1(8), HIF1A(1), JAK2(2), NFKBIA(2), RELA(3)	3579488	20	12	15	4	5	1	5	0	9	0	0.547	0.968	1.000
226	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2), PNPO(1), PSAT1(2)	1349692	5	4	5	3	1	1	3	0	0	0	0.831	0.970	1.000
227	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(3), HK2(3), HK3(4), PGM1(1), TGDS(1)	2852929	13	7	13	4	8	1	2	0	2	0	0.322	0.970	1.000
228	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA4(3), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(7), LDLR(1), LPL(4), LRP1(21), SCARB1(1), SOAT1(1)	7616519	50	27	50	9	20	10	5	3	11	1	0.00956	0.972	1.000
229	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BAK1(1), BCL2L1(7), BIK(1), BIRC2(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1)	3795124	20	11	14	4	2	3	3	2	10	0	0.587	0.974	1.000
230	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2)	4469067	24	15	20	6	3	5	6	1	9	0	0.498	0.974	1.000
231	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(1), HRAS(1), INSR(4), IRS1(30), JAK2(2), PIK3CA(6), PIK3R1(2), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(2), SOS1(14), SRF(1), STAT5A(2)	9233752	72	51	37	11	10	5	6	6	45	0	0.585	0.976	1.000
232	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(5), ARHGEF1(3), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(2), MAP3K7(12), PIK3CA(6), PIK3R1(2), PLCB1(1), PPP1R12B(1), ROCK1(6)	7267551	41	26	32	9	5	9	4	6	17	0	0.348	0.976	1.000
233	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	594511	3	1	3	1	0	1	2	0	0	0	0.756	0.979	1.000
234	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), ESCO1(3), ESCO2(12), SH3GLB1(1)	6939077	39	19	28	9	8	8	2	5	16	0	0.410	0.980	1.000
235	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), SQLE(2)	1204816	6	4	5	3	2	2	1	0	1	0	0.730	0.980	1.000
236	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), HSD3B7(3), PON1(1), PON2(1), RDH11(2)	2505610	13	5	13	2	3	2	3	4	1	0	0.207	0.980	1.000
237	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGP2(6), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), XYLB(2)	7511754	44	25	36	6	4	9	7	11	13	0	0.0977	0.980	1.000
238	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), MIOX(1), UGDH(2)	2391158	9	7	9	3	5	1	1	2	0	0	0.480	0.981	1.000
239	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(3), RDH11(2)	1349588	6	2	6	0	1	0	2	2	1	0	0.192	0.981	1.000
240	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACOT11(1), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), EHHADH(1), ESCO1(3), ESCO2(12), GCDH(2), HADHA(1), SH3GLB1(1)	7221647	29	19	18	5	4	4	3	3	15	0	0.416	0.982	1.000
241	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(2), UXS1(2)	1087579	5	4	5	3	0	1	1	2	1	0	0.924	0.982	1.000
242	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(1), COQ7(1)	1160684	2	2	2	2	0	1	0	0	1	0	0.953	0.982	1.000
243	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACPT(2), ENPP3(3), FLAD1(5), MTMR2(1), MTMR6(2), PHPT1(1), RFK(1), TYR(4)	4191351	20	10	17	5	7	4	3	1	5	0	0.526	0.982	1.000
244	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(1), RB1(3), SP1(1), SP3(1)	1851811	6	2	6	0	1	0	3	1	1	0	0.354	0.982	1.000
245	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(3), CASP9(1), DAXX(6), FAS(3), FASLG(1), MAPKAPK3(1)	3164573	19	9	15	7	3	5	3	2	6	0	0.737	0.983	1.000
246	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3), MASP1(2)	5814449	48	22	46	9	11	7	9	8	13	0	0.0531	0.984	1.000
247	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNAS(16), GNB1(2), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTPRC(3), ZAP70(6)	6541313	50	25	41	7	26	8	6	5	5	0	0.00332	0.984	1.000
248	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNAS(16), GNB1(2), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTPRC(3), ZAP70(6)	6541313	50	25	41	7	26	8	6	5	5	0	0.00332	0.984	1.000
249	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(6), PIK3R1(2), PLCB1(1), PLCG1(1), VAV1(6)	3559335	19	11	18	5	3	4	1	5	5	1	0.437	0.986	1.000
250	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), BAD(1), BCL2L1(7), CASP9(1), CDC42(1), CHUK(1), ELK1(2), HRAS(1), PIK3CA(6), PIK3R1(2), RALBP1(2), RALGDS(2), RELA(3), RHOA(1)	5414471	33	22	26	8	5	5	4	5	14	0	0.545	0.986	1.000
251	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), FBP2(1), GOT1(3), GPT(2), GPT2(3), MDH2(1), ME1(2), ME2(4), ME3(2), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TPI1(3)	5038960	32	13	32	3	6	10	10	3	3	0	0.00276	0.987	1.000
252	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(4), F11(1), F12(3), F13B(2), F5(14), F8(9), FGA(6), FGB(4), FGG(2), LPA(8), PLAT(2), PLG(1), SERPINE1(2), SERPINF2(1), VWF(5)	9802554	64	32	56	15	14	11	18	11	9	1	0.134	0.987	1.000
253	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(1), FDFT1(2), FDPS(1), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NSDHL(2), SQLE(2)	3727666	23	12	22	7	7	6	5	0	5	0	0.407	0.987	1.000
254	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), CSNK1D(1), DRD1(5), EGF(4), EGFR(2), GJA1(1), GNA11(3), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(16), GRM1(17), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HRAS(1), HTR2A(3), HTR2B(1), HTR2C(5), ITPR1(10), ITPR2(12), ITPR3(10), KRAS(142), MAP3K2(2), MAPK7(4), NPR1(5), NPR2(1), PDGFC(2), PDGFRA(3), PDGFRB(7), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PRKACB(1), PRKACG(3), PRKCG(2), PRKG1(1), PRKG2(2), SOS1(14), SOS2(1), SRC(2), TJP1(6), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4)	37290692	392	162	219	63	95	102	107	35	53	0	2.13e-12	0.988	1.000
255	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC2(3), AOC3(3), CES1(2), DDHD1(3), ESCO1(3), ESCO2(12), LIPA(1), PLA1A(2), SH3GLB1(1)	7056043	30	21	19	5	6	3	5	3	13	0	0.367	0.988	1.000
256	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(4), GGT1(1), SHMT1(2), SHMT2(4)	1580415	12	8	12	6	3	4	2	1	2	0	0.698	0.988	1.000
257	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(2), KARS(2)	1305213	4	2	4	3	1	0	1	1	1	0	0.952	0.988	1.000
258	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT2A1(1), SUOX(1)	1680152	11	3	11	4	1	2	1	4	3	0	0.685	0.989	1.000
259	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(1), FUT2(3), FUT9(1), GBGT1(1), HEXA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2)	2825903	17	7	17	2	10	3	3	0	1	0	0.0346	0.989	1.000
260	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(2), ADSL(2), ADSS(3), AGXT(2), AGXT2(2), ASL(3), ASNS(3), ASPA(1), CAD(6), CRAT(5), DARS(1), DDO(2), GAD1(6), GAD2(5), GOT1(3), GPT(2), GPT2(3), PC(3)	7277473	55	29	49	11	15	9	13	6	11	1	0.0792	0.991	1.000
261	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(9), CACNA1D(35), CACNA1F(2), CACNA1S(6), CALML3(1), CALML6(2), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), ELK1(2), FSHB(1), GNA11(3), GNAQ(1), GNAS(16), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(10), ITPR2(12), ITPR3(10), KRAS(142), LHB(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(9), MMP2(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLD2(5), PRKACB(1), PRKACG(3), PRKCD(11), SOS1(14), SOS2(1), SRC(2)	36245360	395	165	194	65	72	95	106	32	87	3	1.72e-09	0.991	1.000
262	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), BIRC2(2), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1), LMNB1(1), LMNB2(1), PRF1(8)	5391730	32	17	27	4	6	6	5	2	13	0	0.145	0.991	1.000
263	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(4), LARS2(2), PDHA1(4), PDHA2(2)	2770266	14	8	12	3	4	5	2	3	0	0	0.282	0.991	1.000
264	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(1), EPX(4), LPO(6), MPO(2), MTHFR(1), SHMT1(2), SHMT2(4), TPO(7)	3242080	29	11	29	7	11	7	6	2	3	0	0.101	0.991	1.000
265	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(5), COL4A2(6), COL4A3(2), COL4A4(13), COL4A5(5), COL4A6(6), SLC2A1(3)	7073361	40	21	32	9	6	5	12	2	14	1	0.553	0.991	1.000
266	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(4), PSMB1(1), PSMB4(6), PSMB5(2), PSMB6(1), PSMD1(4), PSMD11(2), PSMD12(2), PSMD2(1)	4427515	27	18	24	9	8	2	4	4	9	0	0.741	0.992	1.000
267	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(4), ACSS1(1), ACSS2(2), FH(3), IDH1(1), IDH2(5), MDH2(1), SUCLA2(1)	3670897	21	11	20	6	6	3	5	2	5	0	0.562	0.992	1.000
268	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), PC(3), PCK1(3), SDHA(6), SUCLA2(1), SUCLG1(3)	5728549	34	15	32	7	5	6	11	7	5	0	0.237	0.992	1.000
269	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(20), ABCG2(1), BCHE(6), CES1(2), CYP3A5(1), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1)	6285540	49	36	29	10	3	5	5	7	27	2	0.780	0.992	1.000
270	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(1), SHMT1(2), SHMT2(4)	1199303	8	4	8	6	2	3	2	0	1	0	0.888	0.992	1.000
271	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(2), ACADS(1), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH5A1(1), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), L2HGDH(2), OXCT1(2), PDHA1(4), PDHA2(2)	7184162	38	20	36	7	11	11	7	4	4	1	0.0300	0.993	1.000
272	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(1), GREB1(8), MTA1(1), PDZK1(1), TUBA8(4)	3131290	17	9	17	4	4	9	1	1	2	0	0.0759	0.994	1.000
273	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT2(16), B4GALT5(2), DDOST(1), DPAGT1(8), MAN1A1(2), MAN1B1(2), MGAT1(1), MGAT2(5), MGAT3(3), MGAT4B(1), MGAT5(2), ST6GAL1(1)	5613770	45	34	24	10	9	3	2	4	27	0	0.802	0.994	1.000
274	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(2), PGAP1(1), PIGB(3), PIGG(2), PIGL(2), PIGM(1), PIGO(9), PIGP(2), PIGQ(6), PIGS(3), PIGW(2)	6750883	33	14	32	3	9	6	6	5	7	0	0.00658	0.994	1.000
275	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(4), PCYT1A(2), PDHA1(4), PDHA2(2), SLC18A3(3)	1985491	19	13	17	9	6	5	5	1	2	0	0.609	0.994	1.000
276	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(8), ACE2(4), AGT(1), AGTR2(1), ANPEP(3), CMA1(1), CPA3(1), CTSG(2), ENPEP(3), LNPEP(2), MME(2), NLN(1), REN(8), THOP1(1)	5900213	38	19	30	6	4	9	9	5	11	0	0.0932	0.994	1.000
277	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), CSF3(2), HLA-DRB1(1), IL12B(1), IL6(1), IL7(1), TGFB1(1), TGFB2(2)	3750033	13	7	11	5	1	2	1	3	6	0	0.893	0.995	1.000
278	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(2), CASP10(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1), PRF1(8), SCAP(3), SREBF2(5)	5239941	29	16	23	6	6	6	2	2	13	0	0.313	0.995	1.000
279	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), AKAP1(2), AKAP10(2), AKAP11(6), AKAP12(5), AKAP2(9), AKAP3(2), AKAP4(1), AKAP5(1), AKAP6(6), AKAP7(2), AKAP9(9), ARHGEF1(3), GNA11(3), GNA14(1), GNA15(4), GNAI2(1), GNAL(3), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB2(1), GNB3(2), GNB5(1), GNG13(1), HRAS(1), ITPR1(10), KRAS(142), PALM2(1), PDE1B(2), PDE1C(1), PDE4A(2), PDE4C(2), PDE4D(2), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCI(3), PRKCQ(3), PRKD1(1), PRKD3(4), RHOA(1), RRAS(2), USP5(2)	32867723	328	156	175	70	59	97	105	30	35	2	2.59e-06	0.995	1.000
280	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(2), IL10RB(2), IL6(1), JAK1(1), STAT1(3), STAT3(2), STAT5A(2)	3385568	15	7	15	5	7	2	2	1	3	0	0.589	0.995	1.000
281	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(2)	1893310	21	7	20	4	7	7	0	3	4	0	0.0524	0.995	1.000
282	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), PRKCE(1)	2212858	14	4	13	4	6	3	1	1	2	1	0.282	0.995	1.000
283	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(5), AKT1(3), CAMK2D(1), CREB1(2), GNAS(16), HRAS(1), PIK3CA(6), PIK3R1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RPS6KA1(2), RPS6KA5(4), SOS1(14)	8218175	65	41	42	10	22	7	5	7	24	0	0.0836	0.995	1.000
284	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(8), AXIN1(4), CD14(3), CTNNB1(9), DVL1(4), FZD1(5), GJA1(1), GNAI1(1), GSK3B(2), LBP(1), LEF1(3), LY96(1), PIK3CA(6), PIK3R1(2), PPP2CA(1), RELA(3), TLR4(1), WNT1(1)	8672495	59	26	56	8	15	10	8	15	11	0	0.00893	0.995	1.000
285	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), MUT(2)	1381953	4	2	4	2	0	1	0	1	2	0	0.814	0.995	1.000
286	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(5), COL4A2(6), COL4A3(2), COL4A4(13), COL4A5(5), COL4A6(6), F10(4), F11(1), F12(3), F5(14), F8(9), FGA(6), FGB(4), FGG(2), KLKB1(2), PROC(1), PROS1(2), SERPINC1(3), SERPING1(1)	12428152	89	45	73	15	12	14	28	11	22	2	0.0940	0.995	1.000
287	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(3), DHFR(1), IMPDH1(3), MTHFD2(1), POLB(1), POLD1(2), POLG(5), PRPS2(1), RRM1(2)	3606928	21	9	20	4	5	7	1	1	7	0	0.0954	0.996	1.000
288	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11)	3939251	30	17	22	6	3	8	7	10	2	0	0.162	0.996	1.000
289	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), ME1(2), PC(3), PDHA1(4), SLC25A1(1)	2584347	13	7	11	5	4	7	1	1	0	0	0.386	0.996	1.000
290	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(17), ABAT(2), ADSL(2), ADSS(3), ADSSL1(1), AGXT(2), AGXT2(2), ASL(3), ASNS(3), ASPA(1), ASRGL1(1), ASS1(4), CAD(6), CRAT(5), DARS(1), DARS2(2), DDO(2), DLAT(4), GAD1(6), GAD2(5), GOT1(3), GPT(2), GPT2(3), NARS2(2), PC(3), PDHA1(4), PDHA2(2)	10588636	92	49	71	17	22	16	16	8	29	1	0.0312	0.996	1.000
291	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(3), GLI2(5), GLI3(14), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SMO(2), SUFU(1)	4721277	41	21	40	13	18	7	7	5	4	0	0.220	0.996	1.000
292	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELL(1)	2929624	14	6	14	4	4	2	1	3	4	0	0.326	0.996	1.000
293	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACPT(2), ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), CYP3A5(1), CYP3A7(3), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), PON1(1), PON2(1)	5058800	29	13	28	8	10	5	2	6	6	0	0.324	0.997	1.000
294	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(6), CAPN2(1), CAPNS1(3), CAPNS2(2), EP300(6), MEF2D(2), NFATC1(4), NFATC2(10), PPP3CA(3), PPP3CC(2), SYT1(1)	6774478	40	24	36	8	12	9	1	5	13	0	0.0731	0.997	1.000
295	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), EHHADH(1), GCDH(2), HADHA(1)	2167501	6	2	6	1	1	2	2	0	1	0	0.344	0.997	1.000
296	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), FBP2(1), GOT1(3), GPT(2), GPT2(3), MDH2(1), ME1(2), ME3(2), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TKTL1(1), TPI1(3)	5622414	29	13	29	3	6	8	10	2	3	0	0.00976	0.997	1.000
297	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(8), AXIN1(4), BMP2(3), BMP4(2), BMP5(3), BMP7(2), BMPR1A(4), BMPR2(3), CHRD(2), CTNNB1(9), DVL1(4), FZD1(5), GATA4(1), GSK3B(2), MAP3K7(12), MEF2C(2), NKX2-5(1), RFC1(4), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), WNT1(1)	10271663	93	46	82	10	30	16	10	16	21	0	0.000140	0.997	1.000
298	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(1), MTMR6(2), NFS1(2), PHPT1(1), TPK1(1)	1778486	7	4	7	4	3	2	1	0	1	0	0.917	0.997	1.000
299	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(5), CSF1R(5), EGF(4), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SH3KBP1(2), SRC(2)	5383141	28	13	25	4	4	7	5	3	9	0	0.158	0.998	1.000
300	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAT1(2), EHHADH(1), HADHA(1), HADHB(2)	2317983	7	2	7	1	0	3	1	0	3	0	0.287	0.998	1.000
301	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), FGA(6), FGB(4), FGG(2), PLAT(2), PLG(1), SERPINE1(2)	3713527	20	8	19	7	3	4	5	5	3	0	0.605	0.998	1.000
302	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKBIA(2), PLCB1(1), RELA(3)	2303338	7	4	7	5	1	1	2	1	2	0	0.971	0.998	1.000
303	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(1), ARSB(2), ARSE(1), CYP11B1(7), CYP11B2(6), HSD11B1(1), HSD17B2(2), HSD3B1(2), STS(4), SULT2A1(1), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1)	7610270	48	30	38	13	10	10	6	5	17	0	0.461	0.998	1.000
304	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(4), CASP1(4), CASP7(2), CASP8(2), INSR(4), ITCH(3), MAGI1(2), MAGI2(12), RERE(13), WWP1(2), WWP2(6)	6713708	58	33	48	13	17	8	5	7	21	0	0.190	0.998	1.000
305	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(1), LEPR(7), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2)	4006041	17	6	17	3	2	6	1	2	6	0	0.186	0.998	1.000
306	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1D1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), BAAT(1), CEL(14), CYP27A1(3), CYP7A1(2), HADHB(2)	6498338	45	26	35	13	12	8	5	3	17	0	0.533	0.998	1.000
307	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(2), GCK(1), GFPT1(2), GNE(2), GNPDA1(2), GNPDA2(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(4), RENBP(1)	4735333	25	12	25	7	13	4	4	1	3	0	0.241	0.998	1.000
308	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(2), ITGA4(1), ITGAL(3), ITGB2(1), SELE(2), SELL(1)	3371748	14	7	14	6	4	1	2	3	4	0	0.649	0.998	1.000
309	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GPHN(2), SRC(2), UBQLN1(3)	3369458	22	7	21	5	8	4	5	2	2	1	0.176	0.998	1.000
310	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(3), CHST12(1), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT2A1(1), SULT2B1(1), SUOX(1)	2614353	16	8	16	5	5	2	2	4	3	0	0.477	0.998	1.000
311	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(2), FARSB(1), GOT1(3), PAH(1), TAT(1)	2417060	10	7	9	3	3	2	4	1	0	0	0.559	0.999	1.000
312	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3)	1731493	9	2	9	3	3	0	1	2	3	0	0.580	0.999	1.000
313	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), EHHADH(1), HADHA(1)	3389833	10	8	10	3	6	1	2	0	1	0	0.363	0.999	1.000
314	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), CREB1(2), SYT1(1)	3259789	9	5	9	2	3	0	2	0	4	0	0.467	0.999	1.000
315	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ARG2(1), ASL(3), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), OAT(2), ODC1(1), PYCR1(1)	4978972	23	7	22	2	8	3	7	3	1	1	0.0216	0.999	1.000
316	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1)	3702314	21	6	21	7	10	5	2	2	2	0	0.330	0.999	1.000
317	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3)	3822350	18	11	18	6	11	3	1	2	1	0	0.365	0.999	1.000
318	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(4), EGFR(2), HGS(2)	3566725	11	3	11	1	0	5	3	2	1	0	0.138	0.999	1.000
319	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), DDC(1), EPX(4), ESCO1(3), ESCO2(12), GOT1(3), HPD(3), LPO(6), MPO(2), SH3GLB1(1), TAT(1), TPO(7)	9553582	56	28	45	9	20	6	9	5	16	0	0.0329	0.999	1.000
320	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(3), ANXA6(3), CYP11A1(2), EDN1(4), EDNRB(2), HSD11B1(1), PRL(4), PTGDR(2), PTGDS(2), PTGFR(2), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1)	5838229	31	15	29	9	12	2	6	6	5	0	0.401	0.999	1.000
321	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(3), GRIN1(8), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), NOS1(10), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1)	7220370	63	30	57	14	24	8	7	9	15	0	0.0471	0.999	1.000
322	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), CREB1(2), DAXX(6), ELK1(2), HRAS(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K5(2), MAP3K7(12), MAP3K9(4), MAPKAPK5(1), MAX(1), MEF2A(2), MEF2C(2), MEF2D(2), MYC(2), RPS6KA5(4), SHC1(2), STAT1(3), TGFB1(1), TGFB2(2), TGFBR1(8), TRADD(1), TRAF2(1)	10334717	73	44	59	18	16	8	11	7	31	0	0.507	0.999	1.000
323	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(2), IARS(4), ILVBL(2), LARS2(2), PDHA1(4), PDHA2(2), VARS(4), VARS2(3)	5171584	25	13	23	6	10	7	3	3	2	0	0.200	0.999	1.000
324	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), CP(5), CPOX(3), EPRS(1), GUSB(1), HMBS(1), PPOX(2), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1)	7562210	36	21	31	5	4	6	4	8	14	0	0.195	0.999	1.000
325	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), NAT1(2), NAT2(1), XDH(5)	2197664	18	8	18	8	8	2	1	4	3	0	0.735	0.999	1.000
326	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), SP1(1), SP3(1), SYT1(1)	5867296	31	14	27	7	8	7	2	4	10	0	0.194	0.999	1.000
327	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(4), FURIN(2), NOTCH1(10), PSEN1(1)	2727017	17	6	17	8	8	7	1	1	0	0	0.337	0.999	1.000
328	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), DDC(1), EPX(4), GOT1(3), HPD(3), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), TAT(1), TPO(7)	6156453	44	20	43	8	19	7	10	3	5	0	0.0152	1.000	1.000
329	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), ASRGL1(1), CA5A(3), CA5B(2), CA6(1), CA8(1), CA9(1), CPS1(5), GLS(1), GLUD2(3), HAL(1)	5914428	22	11	21	5	4	8	3	2	4	1	0.312	1.000	1.000
330	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(5), AKT1(3), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(4), ITGB3(1), PDGFRA(3), PIK3CA(6), PIK3R1(2), PLCB1(1), PTK2(3), SMPD1(1), SPHK1(1), SRC(2)	7631321	36	16	35	6	8	11	3	6	8	0	0.0383	1.000	1.000
331	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), FUT1(1), FUT2(3), FUT9(1), GBGT1(1), HEXA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2)	2995892	15	7	15	3	8	3	3	0	1	0	0.121	1.000	1.000
332	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(3), EP300(6), ESR1(1), SRC(2)	4210565	12	7	12	3	3	3	4	1	1	0	0.321	1.000	1.000
333	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3), THY1(1)	2968478	13	5	13	3	7	1	0	2	3	0	0.215	1.000	1.000
334	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(1), CDC34(1), CUL1(4), RB1(3), SKP2(3), TFDP1(1)	2406145	16	8	16	8	3	5	4	3	1	0	0.829	1.000	1.000
335	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(2), ITGA4(1), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELL(1), SELP(3)	4461888	18	8	18	7	5	3	2	3	5	0	0.485	1.000	1.000
336	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(4), RB1(3), SKP2(3), TFDP1(1)	2396592	12	7	12	6	2	3	3	3	1	0	0.865	1.000	1.000
337	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH18A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AMD1(1), AOC2(3), AOC3(3), ARG1(1), ARG2(1), ASL(3), ASS1(4), CPS1(5), ODC1(1), SAT2(1)	8279665	30	16	28	3	17	4	4	2	2	1	0.00407	1.000	1.000
338	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(2), CREBBP(3), EP300(6), NCOA3(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RXRA(1)	5765837	26	13	26	8	9	4	6	3	3	1	0.351	1.000	1.000
339	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(3), JAK1(1), JAK2(2), TYK2(2)	2909471	8	5	8	4	2	0	3	1	2	0	0.897	1.000	1.000
340	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(3), JAK1(1), JAK2(2), TYK2(2)	2909471	8	5	8	4	2	0	3	1	2	0	0.897	1.000	1.000
341	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	2411659	7	3	7	5	3	0	2	0	2	0	0.901	1.000	1.000
342	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD4(2), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3), THY1(1)	3117056	15	5	15	4	7	1	0	3	4	0	0.317	1.000	1.000
343	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(2), CD3E(1), CD4(2), IL12B(1), IL12RB1(1), IL12RB2(2), JAK2(2), STAT4(1), TYK2(2)	4135444	14	6	14	6	2	1	3	2	6	0	0.902	1.000	1.000
344	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(1), ARSE(1), CARM1(2), CYP11B1(7), CYP11B2(6), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD17B7(11), HSD3B1(2), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), STS(4), SULT2A1(1), SULT2B1(1), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	13968706	98	53	69	16	14	30	15	21	18	0	0.00295	1.000	1.000
345	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(2), GSK3B(2), PPP1CA(1)	3225117	11	3	11	4	2	3	4	0	2	0	0.702	1.000	1.000
346	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), GSS(1), NOX1(4), RELA(3), XDH(5)	2786464	14	7	14	7	5	3	3	2	1	0	0.849	1.000	1.000
347	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT1(2), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), GRHPR(6), HAGH(2), LDHB(1), MDH2(1), ME1(2), ME2(4), ME3(2), PC(3), PCK1(3), PDHA1(4), PDHA2(2), PKLR(2)	10286541	55	26	49	9	13	22	5	3	12	0	0.00824	1.000	1.000
348	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GNT2(2), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALNT1(1), B4GALT2(16), FUT1(1), FUT2(3), FUT3(1), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GBGT1(1), GCNT2(1), PIGB(3), PIGG(2), PIGL(2), PIGM(1), PIGO(9), PIGP(2), PIGQ(6), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(2), ST6GALNAC5(25), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3), UGCG(1)	13747340	113	62	75	14	26	13	16	8	50	0	0.00343	1.000	1.000
349	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(4), FH(3), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), OGDH(5), PC(3), PDHA1(4), PDHA2(2), PDK1(1), PDK2(3), PDK4(1), SDHA(6), SUCLA2(1), SUCLG1(3)	7938626	46	19	43	10	9	10	13	8	6	0	0.112	1.000	1.000
350	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CYP2C9(2), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), EHHADH(1), ESCO1(3), ESCO2(12), HADHA(1), SH3GLB1(1)	8608216	33	23	22	8	9	3	3	3	15	0	0.557	1.000	1.000
351	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(3), BDKRB2(1), CHRM1(1), CHRNA1(4), FLT1(4), FLT4(11), KDR(1), NOS3(9), PDE2A(1), PDE3A(14), PDE3B(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKG1(1), PRKG2(2), RYR2(26), SLC7A1(1), SYT1(1), TNNI1(1)	11514108	95	51	80	15	35	11	15	6	28	0	0.00144	1.000	1.000
352	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(3), HK2(3), HK3(4), ISYNA1(1), PGM1(1), TGDS(1)	3276862	14	7	14	5	9	1	2	0	2	0	0.350	1.000	1.000
353	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(7), NT5C1B(3), NT5C2(6), NT5E(1), NT5M(1), NUDT12(1)	6012517	30	13	26	8	8	4	7	3	8	0	0.436	1.000	1.000
354	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(3), FBL(1), GPT(2), LDHB(1), NCL(2)	2528350	12	3	11	6	3	1	5	1	2	0	0.885	1.000	1.000
355	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS1(3), SCAP(3), SREBF2(5)	3485307	12	8	10	8	4	2	0	2	4	0	0.944	1.000	1.000
356	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), HRAS(1), MYC(2), NFKBIA(2), PLCB1(1), RELA(3)	4325454	11	6	11	5	2	2	3	1	3	0	0.935	1.000	1.000
357	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BAD(1), BCL2L1(7), CBL(5), CFLAR(3), CRKL(2), HRAS(1), IL2RA(1), IL2RB(2), IRS1(30), JAK1(1), JAK3(3), MYC(2), PIK3CA(6), PIK3R1(2), PTPN6(4), SHC1(2), SOS1(14), STAT5A(2), SYK(2)	10178207	93	65	52	23	13	8	8	9	55	0	0.941	1.000	1.000
358	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(1), CDC42(1), CREB1(2), CREB5(1), DUSP10(1), ELK1(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K10(4), MAP3K4(2), MAP3K5(2), MAP3K7(12), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), MKNK2(3), MYEF2(2), NR2C2(1), SRF(1), TRAF6(1)	9502701	52	35	42	14	9	5	9	5	24	0	0.629	1.000	1.000
359	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), IL4R(3), IRS1(30), JAK1(1), JAK3(3), SHC1(2), STAT6(5)	4170275	47	37	23	15	7	5	3	3	29	0	0.982	1.000	1.000
360	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(7), NT5E(1), NT5M(1)	4055340	20	7	20	6	7	3	5	3	2	0	0.374	1.000	1.000
361	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), EGFR(2), ELK1(2), GNAQ(1), HRAS(1), MAP2K4(5), MAP3K1(3), MAPK8(2), MEF2A(2), MEF2C(2), MEF2D(2), PAK1(19), PTK2(3), SHC1(2), SOS1(14), SRC(2), SYT1(1)	9399720	64	40	35	10	5	7	6	6	40	0	0.408	1.000	1.000
362	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(2), AKT3(4), BAD(1), GSK3A(2), GSK3B(2), IL4R(3), IRS1(30), IRS2(4), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(2), SOS1(14), SOS2(1), STAT6(5)	10420600	92	58	55	22	18	13	5	10	46	0	0.621	1.000	1.000
363	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(2), RELA(3), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(2), TRAF2(1), TRAF5(1), TRAF6(1)	4098821	13	4	13	4	2	1	5	1	4	0	0.718	1.000	1.000
364	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3), MASP1(2)	5970004	48	22	46	11	11	7	9	8	13	0	0.119	1.000	1.000
365	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), ASPA(1), CNDP1(2), DDC(1), HAL(1), HDC(1), PRPS1(1), PRPS2(1)	6815696	26	18	26	5	12	5	4	2	3	0	0.0577	1.000	1.000
366	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(1), AGTR2(1), EDN1(4), EDNRB(2), EGF(4), EGFR(2), HRAS(1), MYC(2), PLCG1(1), RELA(3)	5719904	23	11	21	6	3	4	5	1	10	0	0.566	1.000	1.000
367	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2E1(1), GTF2E2(4), GTF2F1(6), GTF2H1(1), GTF2H4(1), GTF2I(6), GTF2IRD1(2), STON1(2), TAF1(10), TAF1L(7), TAF2(2), TAF4(4), TAF4B(2), TAF5(1), TAF5L(4), TAF6(2), TAF6L(3), TAF7L(1), TAF9(2)	10032117	62	36	48	15	11	5	9	9	28	0	0.794	1.000	1.000
368	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(1), ETV5(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), JAK2(2), MAP2K6(3), MAPK8(2), STAT4(1), TYK2(2)	5232124	18	9	18	6	4	1	4	1	8	0	0.672	1.000	1.000
369	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(6), CTNNB1(9), PTK2(3), PXN(1), SRC(2), VCL(3)	5463774	36	12	36	4	16	10	1	8	1	0	0.00144	1.000	1.000
370	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(2), ATG7(3), BECN1(3), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(1), ULK1(3), ULK3(1)	5960733	25	11	24	6	6	6	1	7	5	0	0.305	1.000	1.000
371	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(4), ACACB(8), AKT1(3), AKT2(2), AKT3(4), ARAF(2), BAD(1), BRAF(4), CALML3(1), CALML6(2), CBL(5), CBLB(2), CBLC(1), CRK(1), CRKL(2), ELK1(2), EXOC7(1), FASN(7), FBP2(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(2), GYS1(3), GYS2(2), HRAS(1), IKBKB(4), INPP5D(1), INSR(4), IRS1(30), IRS2(4), IRS4(4), KRAS(142), LIPE(2), MAPK10(1), MAPK8(2), MAPK9(1), MKNK2(3), PCK1(3), PCK2(5), PDE3A(14), PDE3B(1), PFKL(2), PFKM(3), PFKP(1), PHKA2(7), PHKB(4), PHKG1(2), PHKG2(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(4), PPP1R3C(2), PPP1R3D(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAG3(4), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCI(3), PTPRF(28), PYGB(2), PYGL(2), PYGM(2), RPS6KB2(4), SHC1(2), SHC2(2), SHC4(2), SOCS4(3), SORBS1(1), SOS1(14), SOS2(1), TRIP10(1), TSC1(1), TSC2(8)	45562125	437	167	229	86	77	109	99	33	117	2	1.57e-06	1.000	1.000
372	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(4), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), OGDH(5), OGDHL(2), PC(3), PCK1(3), PCK2(5), SDHA(6), SUCLA2(1), SUCLG1(3)	8286680	49	22	45	13	12	7	12	8	9	1	0.307	1.000	1.000
373	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CASP7(2), CASP8(2), CFLAR(3), DAXX(6), DFFB(1), FAF1(1), LMNB1(1), LMNB2(1), MAP2K4(5), MAP3K1(3), MAP3K7(12), MAPK8(2), PAK1(19), PAK2(3), PRKDC(9), PTPN13(8), RB1(3), SPTAN1(3)	11653561	86	48	56	17	9	7	11	14	45	0	0.630	1.000	1.000
374	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(2), KARS(2)	1921201	6	2	6	3	1	0	3	1	1	0	0.905	1.000	1.000
375	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(2), AKT3(4), BCR(2), BTK(1), CD19(1), CDKN2A(43), DAPP1(2), FLOT2(1), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), PDK1(1), PHF11(1), PIK3CA(6), PLCG2(7), PPP1R13B(1), PREX1(9), PTEN(2), PTPRC(3), RPS6KA1(2), RPS6KA2(2), SAG(1), SYK(2), TEC(2), VAV1(6)	15587638	137	76	111	24	31	14	12	19	60	1	0.0130	1.000	1.000
376	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(3), AKT2(2), AKT3(4), BRD4(6), CBL(5), CDC42(1), CDKN2A(43), F2RL2(2), FLOT2(1), GSK3A(2), GSK3B(2), INPPL1(5), IRS1(30), IRS2(4), IRS4(4), LNPEP(2), PARD3(7), PARD6A(1), PDK1(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), PTEN(2), RPS6KA1(2), RPS6KA2(2), SHC1(2), SORBS1(1), SOS1(14), SOS2(1), YWHAE(3), YWHAH(1)	16760578	163	92	104	31	21	20	11	16	95	0	0.280	1.000	1.000
377	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(2), HDAC5(2), MEF2A(2), MEF2C(2), MEF2D(2), PPARA(1), PPP3CA(3), PPP3CC(2), SYT1(1), YWHAH(1)	5710031	24	11	24	6	5	5	5	3	6	0	0.261	1.000	1.000
378	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(8), FASN(7), MCAT(1), OLAH(3), OXSM(1)	4566051	24	8	22	5	8	6	4	1	4	1	0.0922	1.000	1.000
379	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1D1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), BAAT(1), CEL(14), CYP27A1(3), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(3), SOAT1(1)	8909345	57	27	47	15	16	10	9	5	17	0	0.303	1.000	1.000
380	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), JAK3(3), STAT3(2), TYK2(2)	3330983	10	4	10	9	3	2	3	0	2	0	0.981	1.000	1.000
381	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCR(2), CRKL(2), HRAS(1), JAK2(2), MAP2K4(5), MAP3K1(3), MAPK8(2), MYC(2), PIK3CA(6), PIK3R1(2), SOS1(14), STAT1(3), STAT5A(2)	7837127	49	31	37	10	8	3	6	9	23	0	0.553	1.000	1.000
382	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(8), ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), ATP7A(4), ATP7B(1), COX4I1(1), COX6A1(1), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(3), NDUFV2(3), SDHA(6), SHMT1(2), UQCRB(1), UQCRFS1(1), UQCRH(2)	10661584	64	32	56	17	12	12	10	12	17	1	0.419	1.000	1.000
383	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA5A(3), CA5B(2), CA6(1), CA8(1), CA9(1), CPS1(5), GLS(1), HAL(1)	5286534	18	8	17	4	3	6	2	2	4	1	0.396	1.000	1.000
384	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(3), ANAPC2(4), ANAPC4(3), ANAPC5(6), ANAPC7(1), BTRC(2), CDC16(1), CDC20(1), CDC23(2), CDC27(8), CUL1(4), CUL2(2), CUL3(1), FBXW11(2), FBXW7(6), ITCH(3), SKP1(1), SKP2(3), SMURF2(1), TCEB1(2), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(2), WWP1(2), WWP2(6)	11300214	69	36	64	15	18	13	12	12	14	0	0.0981	1.000	1.000
385	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKM(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RBKS(1), RPE(2), RPIA(1), TALDO1(1), TKT(1)	5708618	30	13	30	9	12	4	8	3	3	0	0.223	1.000	1.000
386	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NFAT5(31), PDE6B(3), PDE6C(1), PDE6G(1), SLC6A13(1)	10084291	75	46	44	14	14	7	10	3	41	0	0.456	1.000	1.000
387	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(6), CPS1(5), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(2), GLS(1), GOT1(3), GPT(2), GPT2(3), GSS(1), NADSYN1(4), PPAT(2), QARS(2)	9262877	51	20	51	12	10	11	15	6	7	2	0.154	1.000	1.000
388	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(3), LDHB(1)	1906164	4	2	4	2	1	0	2	1	0	0	0.898	1.000	1.000
389	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(2), AKT3(4), ARHGEF11(6), CDC42(1), DLG4(3), LPA(8), MAP2K4(5), MAP3K1(3), MAP3K5(2), MAPK8(2), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(7), PIK3CB(3), PLD2(5), PLD3(2), PTK2(3), RDX(4), ROCK1(6), ROCK2(2), SRF(1), TBXA2R(1)	13790702	79	40	74	19	17	13	15	14	20	0	0.163	1.000	1.000
390	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(1), ASL(3), ASS1(4), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), EPRS(1), GLUD2(3), GOT1(3), LAP3(2), NOS1(10), NOS3(9), OAT(2), P4HA1(5), P4HA2(2), P4HA3(2), PARS2(2), PRODH(2), PYCR1(1), RARS(1), RARS2(4)	10102622	76	34	74	13	28	12	19	8	8	1	0.00643	1.000	1.000
391	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1), SYT1(1)	3848791	8	3	8	7	0	2	1	2	3	0	0.942	1.000	1.000
392	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CREB1(2), ELK1(2), GNAI1(1), GNAQ(1), GNAS(16), GNB1(2), HRAS(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1)	9891939	67	33	54	12	29	13	4	8	13	0	0.00722	1.000	1.000
393	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(6), CPS1(5), EARS2(1), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLUD2(3), GOT1(3), GPT(2), GPT2(3), GSR(1), GSS(1), NADSYN1(4), NAGK(1), PPAT(2), QARS(2)	11030353	59	23	59	14	11	13	19	7	7	2	0.122	1.000	1.000
394	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TNFAIP3(2), TRAF6(1)	5092817	19	7	19	7	2	5	7	2	3	0	0.727	1.000	1.000
395	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), GCK(1), GMDS(1), GMPPA(5), HK1(3), HK2(3), HK3(4), PFKFB1(2), PFKFB3(1), PFKFB4(3), PFKM(3), PFKP(1), PMM2(2), TPI1(3)	6703874	37	17	37	11	18	6	9	2	2	0	0.148	1.000	1.000
396	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(4), EEF1A2(1), EEF1D(1), EEF1G(3), EEF2(6), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B2(3), EIF2B3(2), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(8), EIF4G3(7), EIF5(2), EIF5B(12), ETF1(1), GSPT2(1), PABPC1(16), PABPC3(5), SLC35A4(2)	12409203	85	47	60	12	12	14	15	9	35	0	0.108	1.000	1.000
397	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(3), ADCY8(4), CACNA1A(9), CACNA1B(12), GNAS(16), GNB1(2), GNB3(2), GNG13(1), GRM4(4), ITPR3(10), KCNB1(9), PLCB2(5), PRKACB(1), PRKACG(3), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R1(7), TAS1R2(3), TAS1R3(2), TAS2R1(4), TAS2R10(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R4(4), TAS2R41(1), TAS2R42(1), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(1)	16415056	124	56	107	24	54	15	17	14	24	0	0.000542	1.000	1.000
398	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(1), EGR2(3), EGR3(2), GNAQ(1), MAP3K1(3), MYC(2), NFATC1(4), NFATC2(10), NFKBIA(2), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RELA(3), SYT1(1), VIPR2(1)	7830539	48	24	42	15	14	7	5	6	16	0	0.545	1.000	1.000
399	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(4), EXTL1(3), EXTL2(2), EXTL3(6), GLCE(2), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), NDST1(3), NDST3(3), NDST4(3)	5896020	36	12	36	9	13	7	10	3	3	0	0.122	1.000	1.000
400	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(3), CHUK(1), ELK1(2), IKBKB(4), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K7(12), MAPK8(2), NFKBIA(2), PPARA(1), RELA(3), TLR10(1), TLR2(2), TLR3(3), TLR4(1), TLR6(4), TLR9(5), TRAF6(1)	10246239	60	32	50	14	13	6	8	10	23	0	0.338	1.000	1.000
401	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(2), ACADS(1), ACAT1(2), ACSM1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH5A1(1), BDH1(2), BDH2(1), DDHD1(3), EHHADH(1), GAD1(6), GAD2(5), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(2), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(2), PLA1A(2), RDH11(2)	11371578	58	26	56	11	15	15	13	9	5	1	0.0120	1.000	1.000
402	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP2(3), CASP8(2), CRADD(2), DFFB(1), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(5), MAP3K1(3), MAP3K7(12), MAPK8(2), PAK1(19), PAK2(3), PRKDC(9), RB1(3), SPTAN1(3), TNFRSF1A(2), TRADD(1), TRAF2(1)	11063885	76	41	49	10	13	3	11	9	40	0	0.191	1.000	1.000
403	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IKBKB(4), IL1B(1), IL1RAP(2), IL1RN(2), IL6(1), IRAK3(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), MAP3K7(12), MAPK8(2), NFKBIA(2), RELA(3), TGFB1(1), TGFB2(2), TRAF6(1)	8345786	43	25	33	10	6	5	6	6	20	0	0.537	1.000	1.000
404	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKL(2), PFKM(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RBKS(1), RPE(2), RPIA(1), TALDO1(1), TKT(1), TKTL1(1)	6814642	33	14	33	8	13	5	8	3	4	0	0.106	1.000	1.000
405	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CRKL(2), GNAQ(1), HRAS(1), MAP2K3(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PAK1(19), PLCG1(1), SHC1(2), SOS1(14), SRC(2), SYT1(1)	8015284	56	40	27	14	6	5	3	5	37	0	0.937	1.000	1.000
406	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), MANBA(2), NEU4(2)	4699040	20	11	20	7	7	3	4	0	6	0	0.526	1.000	1.000
407	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(4), APC(8), AXIN1(4), BTRC(2), CTNNB1(9), DVL1(4), FZD1(5), GSK3B(2), NOTCH1(10), PSEN1(1), WNT1(1)	6166393	50	17	50	10	17	15	6	9	3	0	0.0109	1.000	1.000
408	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT2(16), FBP2(1), GAA(2), GANAB(4), GCK(1), GLB1(2), HK1(3), HK2(3), HK3(4), LCT(6), MGAM(1), PFKM(3), PFKP(1), PGM1(1)	9141302	49	31	36	13	16	5	6	1	21	0	0.446	1.000	1.000
409	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(8), AXIN1(4), CREBBP(3), CTNNB1(9), DVL1(4), EP300(6), FZD1(5), GSK3B(2), LDB1(2), LEF1(3), TRRAP(11), WNT1(1)	9286604	58	21	57	12	20	10	9	13	6	0	0.0276	1.000	1.000
410	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(11), GNAQ(1), GNAS(16), GNB1(2), HRAS(1), LIMK1(1), NOX1(4), PLCB1(1), PPP1R12B(1), PTK2(3), ROCK2(2)	7128914	43	28	24	11	17	6	3	3	13	1	0.538	1.000	1.000
411	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(2), MARS2(2), METTL2B(2), METTL6(1), PAPSS1(2), PAPSS2(4), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), SCLY(2), SEPHS2(5)	6970474	44	24	35	14	11	9	10	11	3	0	0.316	1.000	1.000
412	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(2), ACVR1C(2), BAIAP2(4), CDC42(1), CDH1(1), CREBBP(3), CSNK2A1(1), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTNND1(3), EGFR(2), EP300(6), ERBB2(6), FARP2(3), FER(6), FGFR1(1), FYN(9), IGF1R(6), INSR(4), IQGAP1(3), LEF1(3), LMO7(7), MAP3K7(12), MET(4), MLLT4(5), NLK(2), PARD3(7), PTPN6(4), PTPRB(10), PTPRF(28), PTPRJ(3), PTPRM(6), PVRL1(19), PVRL2(1), PVRL3(1), PVRL4(4), RAC2(1), RHOA(1), SMAD2(1), SMAD3(1), SMAD4(41), SORBS1(1), SRC(2), SSX2IP(2), TCF7(2), TCF7L1(4), TCF7L2(1), TGFBR1(8), TGFBR2(10), TJP1(6), VCL(3), WASF1(1), WASF2(2), WASF3(24), WASL(6), YES1(1)	33477707	329	123	237	38	67	38	34	40	148	2	4.14e-06	1.000	1.000
413	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(6), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1R(6), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(2), MEF2C(2), MEF2D(2), NFATC1(4), NFATC2(10), PIK3CA(6), PIK3R1(2), PPP3CA(3), PPP3CC(2), SYT1(1), YWHAH(1)	9779759	66	31	61	14	18	12	9	8	19	0	0.0283	1.000	1.000
414	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(3), CPO(2), HBB(1), HMBS(1)	2254333	7	5	7	4	4	1	1	0	1	0	0.788	1.000	1.000
415	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3)	4694728	22	6	22	3	7	6	5	1	3	0	0.0509	1.000	1.000
416	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(2), RELA(3), TANK(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	6882445	38	14	38	10	10	6	9	5	8	0	0.265	1.000	1.000
417	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MIOX(1), OCRL(1), PIK3C2A(5), PIK3C2B(12), PIK3CA(6), PIK3CB(3), PIK3CG(5), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7)	12613388	66	27	64	14	22	9	7	12	16	0	0.0535	1.000	1.000
418	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(2), MAP2K4(5), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(3), SMPD1(1), TNFRSF1A(2), TRADD(1), TRAF2(1)	5793492	22	9	22	8	6	1	5	4	6	0	0.768	1.000	1.000
419	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(5), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(11), NCF2(1), PAK1(19), PDGFRA(3), PIK3CA(6), PIK3R1(2), PPP1R12B(1), RALBP1(2), TRIO(9), VAV1(6), WASF1(1)	9745699	73	38	49	16	14	10	6	9	32	2	0.425	1.000	1.000
420	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(3), ADCY3(7), ADCY9(5), ARF1(2), ARF3(1), ARF4(1), ARL4D(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), ERO1L(1), GNAS(16), PDIA4(2), PLCG1(1), PLCG2(7), SEC61A1(1), SEC61A2(2), SEC61B(1), SEC61G(1), TRIM23(1)	10380642	74	33	61	17	28	12	12	6	16	0	0.0802	1.000	1.000
421	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(2), AKT3(4), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(4), ITPKB(3), LYN(1), NFAT5(31), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), PLCG2(7), PPP1R13B(1), SHC1(2), SOS1(14), SOS2(1), SYK(2), VAV1(6)	14810358	105	60	66	25	21	12	6	12	53	1	0.566	1.000	1.000
422	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(5), DDX20(1), E2F4(3), ETS1(3), ETS2(2), HDAC5(2), HRAS(1), NCOR2(5), RBL1(1), RBL2(2), SIN3A(6)	7447741	33	15	30	10	6	7	7	5	8	0	0.424	1.000	1.000
423	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BIRC2(2), CASP10(2), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), DFFB(1), GAS2(4), NFKBIA(2), RELA(3), SPTAN1(3), TNFRSF10A(2), TNFRSF10B(2), TNFSF12(2), TRADD(1), TRAF2(1)	9463044	37	15	37	8	12	7	6	3	9	0	0.133	1.000	1.000
424	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(2), ACVR1C(2), ACVR2A(9), ACVRL1(1), AMH(2), AMHR2(5), BMP2(3), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMP8A(1), BMP8B(1), BMPR1A(4), BMPR2(3), CHRD(2), COMP(4), CREBBP(3), CUL1(4), DCN(1), E2F4(3), E2F5(3), EP300(6), GDF5(2), GDF6(1), GDF7(2), INHBA(2), INHBB(2), INHBC(1), LEFTY2(1), LTBP1(2), MYC(2), NODAL(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), RBL1(1), RBL2(2), RHOA(1), ROCK1(6), ROCK2(2), RPS6KB2(4), SKP1(1), SMAD2(1), SMAD3(1), SMAD4(41), SMAD7(1), SMAD9(3), SMURF2(1), SP1(1), TFDP1(1), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), THBS1(7), THBS2(4), THBS3(1), THBS4(34), ZFYVE16(5), ZFYVE9(4)	27975284	239	108	196	39	53	34	30	28	94	0	0.000890	1.000	1.000
425	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CEL(14), DGAT1(3), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), GLB1(2), LCT(6), LIPF(2), LIPG(4), LPL(4), PNLIP(2), PPAP2B(2), PPAP2C(1)	13629084	90	37	80	27	33	12	8	8	29	0	0.206	1.000	1.000
426	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), MAN2B1(2), MAN2B2(2), MANBA(2), NEU4(2)	5782790	24	13	24	9	9	3	5	0	7	0	0.511	1.000	1.000
427	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2M1(1), ARF1(2), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(2), GSK3B(2), LYN(1), PFKL(2), PFKM(3), PFKP(1), PLCG1(1), PRKCE(1)	7157597	25	10	23	7	7	8	3	2	5	0	0.246	1.000	1.000
428	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(9), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAR2B(1), PRKCE(1)	5042466	21	8	21	9	6	4	4	5	2	0	0.820	1.000	1.000
429	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CANX(2), CD4(2), CD8B(2), CREB1(2), CTSB(2), CTSS(2), HLA-A(7), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(3), HSP90AA1(10), HSP90AB1(7), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL3(2), KIR3DL1(3), KLRC3(2), KLRC4(1), LGMN(1), NFYC(1), PDIA3(2), RFX5(1), TAP1(4), TAP2(1), TAPBP(1)	13070707	73	41	62	17	10	16	8	14	25	0	0.237	1.000	1.000
430	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(6), DIAPH1(7), FYN(9), GSN(6), HRAS(1), ITGA1(7), MYLK(11), PIK3CA(6), PIK3R1(2), PTK2(3), PXN(1), ROCK1(6), SHC1(2), SRC(2), TLN1(11)	10419698	80	41	68	13	19	18	9	9	24	1	0.0111	1.000	1.000
431	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT2(16), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(2), HK1(3), HK2(3), HK3(4), HSD3B7(3), LCT(6), MGAM(1), PFKL(2), PFKM(3), PFKP(1), PGM1(1), RDH11(2), UGP2(6)	10862136	59	34	44	15	19	7	6	4	23	0	0.340	1.000	1.000
432	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(4), F2RL1(2), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(2), PLD2(5), PLD3(2), PTK2(3), RASAL1(6), SRC(2), TEC(2), VAV1(6)	7752533	47	15	44	12	15	12	7	4	8	1	0.0855	1.000	1.000
433	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(2), ACACA(4), ACADL(2), ACADM(2), ACADSB(3), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3)	9192870	34	14	34	6	9	8	5	6	6	0	0.0831	1.000	1.000
434	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B1(1), EIF2B2(3), EIF2B3(2), EIF2B5(1), ELAVL1(1), FLT1(4), FLT4(11), HIF1A(1), HRAS(1), KDR(1), NOS3(9), PIK3CA(6), PIK3R1(2), PLCG1(1), PTK2(3), PXN(1), SHC1(2)	9544945	50	26	50	12	14	12	11	3	10	0	0.119	1.000	1.000
435	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(4), ERBB4(6), PSEN1(1)	2533711	11	3	11	5	1	5	1	3	1	0	0.778	1.000	1.000
436	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(3), AKT2(2), AKT3(4), BAD(1), BCL2L1(7), CDC42(1), CDKN2A(43), CREB1(2), CREB5(1), ERBB4(6), F2RL2(2), GSK3A(2), GSK3B(2), IFI27(1), INPPL1(5), IRS1(30), IRS2(4), IRS4(4), MET(4), MYC(2), NOLC1(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PARD3(7), PARD6A(1), PDK1(1), PIK3CA(6), PIK3CD(2), PPP1R13B(1), PREX1(9), PTEN(2), PTK2(3), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS1(14), SOS2(1), TSC1(1), TSC2(8), YWHAE(3), YWHAH(1)	21757173	222	110	136	45	29	22	17	21	133	0	0.486	1.000	1.000
437	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(8), ACAT1(2), ACOT12(3), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), GRHPR(6), HAGH(2), LDHAL6B(2), LDHB(1), MDH2(1), ME1(2), ME2(4), ME3(2), PC(3), PCK1(3), PCK2(5), PDHA1(4), PDHA2(2), PKLR(2)	13002680	72	33	64	15	21	22	6	4	18	1	0.0213	1.000	1.000
438	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(2), ACAT1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(6), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(7), OGDH(5), OGDHL(2), PLOD1(2), RDH11(2), SETD1A(30), SETDB1(3), SHMT1(2), SHMT2(4), SPCS1(1), SUV39H2(3), TMLHE(1)	16272607	95	55	67	23	21	13	15	7	39	0	0.382	1.000	1.000
439	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3E(1), ELK1(2), FYN(9), HRAS(1), LCK(1), MAP2K4(5), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKBIA(2), PIK3CA(6), PIK3R1(2), PLCG1(1), PPP3CA(3), PPP3CC(2), RASA1(4), RELA(3), SHC1(2), SOS1(14), SYT1(1), VAV1(6), ZAP70(6)	13399013	97	50	74	14	18	15	8	13	42	1	0.0200	1.000	1.000
440	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), CASP8(2), CFLAR(3), MAP2K4(5), MAP3K7(12), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	7736955	39	21	30	12	9	3	7	6	14	0	0.724	1.000	1.000
441	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(3), GPI(3), HK1(3), HK2(3), HK3(4), LDHAL6B(2), LDHB(1), MDH2(1), PC(3), PCK1(3), PDHA1(4), PDHA2(2), PFKL(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PKLR(2), TPI1(3)	11801608	61	25	59	13	25	17	10	4	5	0	0.00700	1.000	1.000
442	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(3), EP300(6), FYN(9), IL7(1), IL7R(3), JAK1(1), JAK3(3), LCK(1), PIK3CA(6), PIK3R1(2), STAT5A(2)	7865046	37	26	28	11	8	4	6	4	15	0	0.674	1.000	1.000
443	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(3), AKT1(3), ANGPTL2(2), CDC42(1), FLNA(10), FLNC(12), FSCN1(1), FSCN3(3), GDI1(1), GDI2(3), LIMK1(1), MYH2(4), MYLK(11), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), ROCK1(6), ROCK2(2), WASF1(1), WASL(6)	13549358	100	54	79	24	20	15	15	12	38	0	0.303	1.000	1.000
444	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(3), AKT2(2), AKT3(4), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(7), PIK3CB(3), PLD2(5), PLD3(2)	12686371	75	42	65	18	24	11	10	7	23	0	0.168	1.000	1.000
445	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(3), BLVRA(2), COX15(1), CP(5), CPOX(3), EARS2(1), EPRS(1), FTH1(5), FTMT(3), GUSB(1), HMBS(1), PPOX(2), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	11685888	58	32	48	11	8	13	6	11	20	0	0.175	1.000	1.000
446	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(3), EP300(6), IKBKB(4), NFKBIA(2), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6318203	24	12	24	9	6	4	8	2	4	0	0.665	1.000	1.000
447	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(8), ASAH1(1), CAMP(2), CERK(1), CREB1(2), CREB5(1), DAG1(2), EPHB2(4), GNAQ(1), ITPKB(3), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1)	8142870	45	19	45	12	14	5	7	9	10	0	0.197	1.000	1.000
448	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPT(2), ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2D6(1), CYP2E1(3), CYP2F1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), CYP4B1(1), CYP51A1(1), PON1(1)	8186065	58	25	55	18	21	7	11	9	10	0	0.298	1.000	1.000
449	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(2), SOS1(14), STAT5A(2), SYK(2)	6631097	34	20	23	11	8	5	1	3	17	0	0.792	1.000	1.000
450	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(2), ARHGAP5(6), ARHGAP6(3), ARHGEF1(3), ARHGEF11(6), ARHGEF5(4), ARPC1A(2), ARPC2(1), BAIAP2(4), DIAPH1(7), GSN(6), LIMK1(1), MYLK(11), PIP5K1B(2), PPP1R12B(1), ROCK1(6), SRC(2), TLN1(11), VCL(3)	12893721	81	37	75	19	22	19	11	10	18	1	0.0299	1.000	1.000
451	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), ASPA(1), CARM1(2), CNDP1(2), DDC(1), FTCD(2), HAL(1), HDC(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), PRPS1(1), PRPS2(1), UROC1(5)	11100192	57	31	48	10	15	10	12	13	7	0	0.0159	1.000	1.000
452	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH4A1(3), AMD1(1), AOC2(3), AOC3(3), ARG1(1), ARG2(1), ASL(3), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), GOT1(3), NOS1(10), NOS3(9), OAT(2), ODC1(1), P4HA1(5), P4HA2(2), P4HA3(2), PYCR1(1), RARS(1)	12412093	74	30	73	9	32	13	17	6	5	1	0.000103	1.000	1.000
453	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(7), ACTB(2), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(3), CDC42(1), CDH1(1), CTNNB1(9), CTTN(2), FYN(9), HCLS1(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(6), ROCK2(2), TLR4(1), TLR5(3), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4), WASL(6)	14666113	100	50	87	18	29	17	11	13	30	0	0.0151	1.000	1.000
454	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(7), ACTB(2), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(3), CDC42(1), CDH1(1), CTNNB1(9), CTTN(2), FYN(9), HCLS1(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(6), ROCK2(2), TLR4(1), TLR5(3), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4), WASL(6)	14666113	100	50	87	18	29	17	11	13	30	0	0.0151	1.000	1.000
455	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	146	APC(8), APC2(2), AXIN1(4), AXIN2(1), BTRC(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(10), CREBBP(3), CSNK1A1(1), CSNK1A1L(4), CSNK1E(1), CSNK2A1(1), CTBP2(3), CTNNB1(9), CUL1(4), CXXC4(1), DAAM1(11), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(4), DVL3(2), EP300(6), FBXW11(2), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GSK3B(2), LEF1(3), LRP5(7), LRP6(5), MAP3K7(12), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(2), MYC(2), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NKD1(4), NKD2(1), NLK(2), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPARD(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP3CA(3), PPP3CC(2), PRICKLE1(3), PRICKLE2(4), PRKACB(1), PRKACG(3), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(6), ROCK2(2), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD2(1), SMAD3(1), SMAD4(41), SOX17(1), TCF7(2), TCF7L1(4), TCF7L2(1), TP53(119), VANGL1(2), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(7), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1)	46126808	480	161	391	87	129	66	53	70	162	0	3.11e-07	1.000	1.000
456	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), GALNT1(3), GALNT10(6), GALNT13(2), GALNT14(1), GALNT2(2), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT4(1), OGT(2), ST3GAL1(2), ST3GAL2(1), WBSCR17(2)	8985944	36	18	35	10	12	6	9	4	5	0	0.299	1.000	1.000
457	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(4), CRK(1), CRKL(2), DOCK1(5), ELK1(2), HGF(1), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PAK1(19), PIK3CA(6), PIK3R1(2), PTEN(2), PTK2(3), PXN(1), RAP1B(3), RASA1(4), SOS1(14), SRC(2), STAT3(2)	12550110	90	50	61	16	13	18	5	9	45	0	0.159	1.000	1.000
458	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(8), GAL3ST1(1), GALC(2), GBA(4), GLB1(2), LCT(6), NEU4(2), PPAP2B(2), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD1(1), SMPD3(1), SMPD4(3), SPHK1(1), SPHK2(1), SPTLC1(3), SPTLC2(1), UGCG(1), UGT8(1)	10145079	50	25	47	14	20	11	5	7	7	0	0.0496	1.000	1.000
459	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(2), ACADM(2), ACOX1(1), ACOX2(2), ACOX3(2), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ANGPTL4(1), APOA5(3), AQP7(14), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP27A1(3), CYP4A22(2), CYP7A1(2), CYP8B1(2), EHHADH(1), FABP4(1), FADS2(15), GK2(5), HMGCS2(1), ILK(1), LPL(4), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(5), PLTP(1), PPARA(1), PPARD(2), PPARG(1), RXRA(1), RXRB(1), RXRG(1), SCD(12), SCP2(1), SLC27A1(3), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(2), SORBS1(1), UBC(2), UCP1(1)	18226623	137	64	103	27	30	27	25	9	44	2	0.0158	1.000	1.000
460	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(4), AMOTL1(2), ASH1L(9), CDC42(1), CDK4(2), CGN(1), CLDN17(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTTN(2), EPB41(4), EPB41L1(3), EPB41L2(3), EPB41L3(4), EXOC3(1), EXOC4(8), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), IGSF5(1), INADL(1), JAM2(2), KRAS(142), LLGL1(5), LLGL2(3), MAGI1(2), MAGI2(12), MAGI3(2), MLLT4(5), MPDZ(4), MRAS(2), MYH1(6), MYH10(38), MYH11(8), MYH13(4), MYH14(7), MYH15(10), MYH2(4), MYH3(2), MYH4(10), MYH6(7), MYH7(8), MYH7B(8), MYH8(6), MYH9(4), MYL9(1), PARD3(7), PARD6A(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP2R3A(4), PPP2R3B(2), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCI(3), PRKCQ(3), PTEN(2), RAB13(1), RHOA(1), RRAS(2), SPTAN1(3), SRC(2), SYMPK(5), TJP1(6), TJP2(5), TJP3(3), YES1(1), ZAK(5)	54687721	485	166	294	87	94	111	122	51	107	0	1.86e-08	1.000	1.000
461	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADL(2), ACADM(2), ACADS(1), ACADSB(3), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), BCAT1(2), BCKDHA(4), BCKDHB(2), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2)	10018499	46	19	44	6	13	12	7	4	10	0	0.00463	1.000	1.000
462	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(2), BLNK(1), ELK1(2), HRAS(1), LYN(1), MAP3K1(3), MAPK8IP3(5), PAPPA(3), RPS6KA1(2), SHC1(2), SOS1(14), SYK(2), VAV1(6)	9046787	44	27	32	11	10	4	4	5	20	1	0.553	1.000	1.000
463	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), ELK1(2), FCER1A(1), FCER1G(1), HRAS(1), LYN(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PAK2(3), PIK3CA(6), PIK3R1(2), PLCG1(1), PPP3CA(3), PPP3CC(2), SHC1(2), SOS1(14), SYK(2), SYT1(1), VAV1(6)	12010420	83	38	68	16	17	14	7	13	31	1	0.0833	1.000	1.000
464	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(2), AKT3(4), CISH(1), IARS(4), IL4R(3), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(6), PPP1R13B(1), SHC1(2), SOS1(14), SOS2(1), SRC(2), STAT6(5), TYK2(2)	10361829	57	32	44	16	11	8	7	9	22	0	0.611	1.000	1.000
465	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(3), CAPNS2(2), ITGA1(7), ITGB3(1), PTK2(3), PXN(1), SPTAN1(3), SRC(2), TLN1(11)	8031855	43	11	43	6	15	13	5	4	6	0	0.00228	1.000	1.000
466	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(3), AKT2(2), AKT3(4), APC(8), AXIN1(4), AXIN2(1), CSNK1A1(1), CTNNB1(9), DACT1(4), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(2), GSK3B(2), LRP1(21), MVP(3), NKD1(4), NKD2(1), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(2), WIF1(2)	11489728	83	37	80	17	31	15	12	12	13	0	0.0133	1.000	1.000
467	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG10B(2), ALG11(3), ALG12(4), ALG13(2), ALG5(1), ALG9(1), B4GALT2(16), DDOST(1), DHDDS(1), DOLPP1(1), DPAGT1(8), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(5), MGAT3(3), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1)	11964724	69	39	48	13	14	12	6	7	30	0	0.244	1.000	1.000
468	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), AOX1(2), DBH(1), DCT(3), DDC(1), FAH(1), GOT1(3), HGD(2), HPD(3), TAT(1), TH(1), TPO(7), TYR(4)	8864271	55	20	55	19	23	8	10	6	7	1	0.257	1.000	1.000
469	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), ATP8A1(3), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKAR(8), CCKBR(3), CCR1(2), CCR10(2), CCR2(1), CCR3(11), CCR4(4), CCR7(1), CX3CR1(1), CXCR4(3), EDNRB(2), FPR1(2), FSHR(4), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(2), MC2R(2), MC3R(4), MC5R(3), NMBR(1), NPY1R(3), NPY2R(3), NPY5R(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(2), SSTR1(4), SSTR3(2), SSTR4(3), TACR1(3), TACR2(1), TACR3(4), TRHR(2), TSHR(3)	14645425	111	51	96	30	35	13	23	14	24	2	0.0649	1.000	1.000
470	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHB(1), PDHA1(4), PDHA2(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PGM1(1), PKLR(2), TPI1(3)	13586408	73	26	71	18	35	18	8	5	7	0	0.0113	1.000	1.000
471	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHB(1), PDHA1(4), PDHA2(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PGM1(1), PKLR(2), TPI1(3)	13586408	73	26	71	18	35	18	8	5	7	0	0.0113	1.000	1.000
472	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(8), AR(4), ASAH1(1), BRAF(4), CAMP(2), CCL16(1), DAG1(2), EGFR(2), GNA11(3), GNA15(4), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), MAPK10(1), PHKA2(7), PIK3CA(6), PIK3CD(2), PIK3R1(2), SRC(2)	15078744	92	47	83	20	24	12	15	12	29	0	0.0774	1.000	1.000
473	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), SYT1(1), TRAF2(1), TRAF5(1), TRAF6(1)	9699048	43	19	43	13	10	9	9	7	8	0	0.210	1.000	1.000
474	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(1), CAPN2(1), CAPNS1(3), CAPNS2(2), EGF(4), EGFR(2), HRAS(1), ITGA1(7), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTK2(3), PXN(1), TLN1(11)	9220196	60	19	60	12	24	16	8	7	5	0	0.00524	1.000	1.000
475	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNGR1(2), JAK1(1), JAK2(2), PTPRU(6), REG1A(2), STAT1(3)	3185640	17	9	16	9	8	0	5	2	2	0	0.889	1.000	1.000
476	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(2), ACAA1(1), ACADM(2), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), AUH(1), BCAT1(2), BCAT2(2), BCKDHA(4), BCKDHB(2), DBT(3), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HIBCH(10), HMGCS2(1), HSD17B4(3), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2), OXCT2(1)	12017079	63	31	52	10	17	10	10	5	21	0	0.0266	1.000	1.000
477	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(5), CSK(1), DAG1(2), DTYMK(1), EPHB2(4), FBXW7(6), GRAP2(2), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFAT5(31), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PLCG1(1), PTPRC(3), RASGRP1(2), RASGRP2(1), RASGRP3(2), SOS1(14), SOS2(1), VAV1(6), ZAP70(6)	15840294	127	70	72	22	20	16	10	9	71	1	0.385	1.000	1.000
478	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), ELK1(2), HRAS(1), LYN(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), SHC1(2), SOS1(14), SYK(2), SYT1(1), VAV1(6)	10683400	63	29	48	14	13	11	3	9	26	1	0.255	1.000	1.000
479	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CHUK(1), DAXX(6), EGF(4), EGFR(2), ETS1(3), ETS2(2), HOXA7(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK13(1), MAPK8(2), NFKBIA(2), PPP2CA(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCQ(3), RELA(3), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1)	13818710	79	41	68	24	15	12	14	11	27	0	0.560	1.000	1.000
480	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(4), AR(4), ESR1(1), ESR2(3), ESRRA(2), NPM1(1), NR0B1(3), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(3), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), PGR(4), PPARA(1), PPARD(2), PPARG(1), RARB(2), RARG(2), ROR1(4), RORA(1), RORC(1), RXRA(1), RXRB(1), RXRG(1), THRA(5), THRB(1)	11972866	68	28	62	19	22	15	10	6	15	0	0.0798	1.000	1.000
481	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(4), ADRA1D(1), ADRA2A(1), ADRA2C(3), ADRB2(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), DRD1(5), DRD3(1), DRD5(5), HRH2(2), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(5), HTR7(1)	7306002	56	31	53	22	22	9	12	8	5	0	0.489	1.000	1.000
482	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(1), ELK1(2), FPR1(2), GNA15(4), GNB1(2), HRAS(1), MAP2K3(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKBIA(2), PAK1(19), PLCB1(1), PPP3CA(3), PPP3CC(2), RELA(3), SYT1(1)	10804863	74	40	52	17	15	12	10	6	31	0	0.376	1.000	1.000
483	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(1), AKT1(3), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(3), CSNK1A1(1), EDN1(4), ELSPBP1(2), FKBP1A(1), GATA4(1), GSK3B(2), HAND2(1), HRAS(1), LIF(2), MAPK8(2), MEF2C(2), MYH2(4), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NKX2-5(1), PIK3CA(6), PIK3R1(2), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1)	14215439	84	38	77	19	29	14	13	10	18	0	0.0279	1.000	1.000
484	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2RL3(1), GNAI1(1), GNB1(2), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(2), PTK2(3), SRC(2), SYK(2), TBXAS1(1)	6806211	23	4	23	9	7	8	2	4	2	0	0.640	1.000	1.000
485	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(4), MAP3K1(3), MAP3K7(12), NFKBIA(2), RELA(3), TLR4(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6918258	33	19	24	11	5	3	8	4	13	0	0.913	1.000	1.000
486	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(7), ABLIM1(6), ABLIM2(2), ABLIM3(2), ARHGEF12(6), CDC42(1), CDK5(5), CXCR4(3), DCC(4), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNB2(1), EPHA1(4), EPHA2(5), EPHA3(2), EPHA4(4), EPHA5(7), EPHA6(2), EPHA7(3), EPHA8(8), EPHB1(2), EPHB2(4), EPHB3(4), EPHB4(5), EPHB6(11), FYN(9), GNAI1(1), GNAI2(1), GSK3B(2), HRAS(1), KRAS(142), L1CAM(6), LIMK1(1), LIMK2(2), LRRC4C(3), MET(4), NCK1(3), NCK2(2), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NGEF(7), NRP1(1), NTN4(1), NTNG1(3), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(9), PLXNA3(8), PLXNB1(6), PLXNB2(6), PLXNB3(6), PLXNC1(4), PPP3CA(3), PPP3CC(2), PTK2(3), RAC2(1), RASA1(4), RGS3(2), RHOA(1), RHOD(1), RND1(2), ROBO1(8), ROBO2(7), ROBO3(11), ROCK1(6), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(5), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(1), SEMA4C(5), SEMA4F(3), SEMA4G(3), SEMA5A(6), SEMA5B(4), SEMA6A(2), SEMA6C(3), SEMA6D(1), SEMA7A(1), SLIT1(8), SLIT2(7), SLIT3(7), SRGAP1(9), SRGAP2(1), SRGAP3(11), UNC5A(10), UNC5B(3), UNC5C(3), UNC5D(11)	55944235	581	175	344	119	116	126	121	57	160	1	2.82e-06	1.000	1.000
487	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(2), AKT3(4), ASAH1(1), BRAF(4), DAG1(2), EGFR(2), EPHB2(4), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), PIK3CB(3), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), SHC1(2), SOS1(14), SOS2(1), SRC(2), STAT3(2), TERF2IP(1)	16454092	95	51	77	20	23	9	11	12	40	0	0.249	1.000	1.000
488	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(4), AGPAT1(1), AGPAT3(3), AGPAT4(3), CDIPT(3), CHAT(4), CPT1B(5), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), GNPAT(1), GPD1(1), GPD2(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(2), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLCB2(5), PLCG1(1), PLCG2(7), PPAP2B(2), PPAP2C(1)	14194517	75	28	75	21	23	10	15	11	16	0	0.162	1.000	1.000
489	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(2), CREBBP(3), EP300(6), ERCC3(16), ESR1(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(6), HDAC4(4), HDAC5(2), HDAC6(1), MEF2C(2), NCOR2(5), NR0B1(3), NRIP1(1), POLR2A(6), TBP(3)	13217759	70	42	53	21	15	8	12	6	29	0	0.742	1.000	1.000
490	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A2(2), EIF4B(3), EIF4G1(8), EIF4G2(1), EIF4G3(7), FKBP1A(1), PDK2(3), PIK3CA(6), PIK3R1(2), PPP2CA(1), PTEN(2), TSC1(1), TSC2(8)	7717848	48	23	46	14	14	10	11	6	7	0	0.418	1.000	1.000
491	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLB(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLG(5), POLH(1), POLI(1), POLK(3), POLL(2), POLM(2), POLQ(3), PRIM1(1), REV1(1), REV3L(6)	11450899	42	14	40	7	8	8	9	8	9	0	0.102	1.000	1.000
492	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), CLOCK(23), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(1), ETV6(3), GFRA1(3), GSTP1(1), HERPUD1(2), HSPA8(3), IDI1(1), MYF6(1), NCKAP1(4), NCOA4(1), NR1D2(1), PER1(5), PER2(5), PPP1R3C(2), PURA(1), TOB1(8), TUBB3(3), UCP3(1), UGP2(6), ZFR(3)	10305653	84	51	53	26	12	8	6	14	43	1	0.972	1.000	1.000
493	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(2), ACACA(4), ACACB(8), ACADM(2), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), HIBCH(10), LDHAL6B(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3)	11016800	50	25	41	10	14	8	6	5	17	0	0.196	1.000	1.000
494	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(1), PTPRU(6), REG1A(2), STAT1(3), STAT2(2), TYK2(2)	3485751	18	9	17	9	10	0	5	2	1	0	0.818	1.000	1.000
495	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(2), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHAL6B(2), LDHB(1), PDHA1(4), PDHA2(2), PFKL(2), PFKM(3), PFKP(1), PGAM1(1), PGAM4(2), PGK1(3), PGM1(1), PKLR(2), TPI1(3)	16213255	86	31	84	23	39	22	10	5	10	0	0.0172	1.000	1.000
496	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(3), ANGPTL2(2), DAG1(2), DGKA(2), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NR1I3(1), PAK1(19), PDE3A(14), PDE3B(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), RIPK3(2), SGCB(1)	13750940	92	54	64	19	20	8	12	6	46	0	0.372	1.000	1.000
497	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), AOX1(2), CARM1(2), DBH(1), DCT(3), DDC(1), ESCO1(3), ESCO2(12), FAH(1), GOT1(3), HEMK1(1), HGD(2), HPD(3), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), SH3GLB1(1), TAT(1), TH(1), TPO(7), TYR(4), TYRP1(1)	16603983	100	44	81	25	27	15	18	18	21	1	0.116	1.000	1.000
498	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1C1(1), AKR1C3(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), CYP1A1(2), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2F1(3), CYP2S1(2), CYP3A5(1), CYP3A7(3), EPHX1(7), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	16031713	104	41	89	26	24	20	18	14	28	0	0.137	1.000	1.000
499	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(3), APC(8), ASAH1(1), CAMP(2), DAG1(2), DLG4(3), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), RYR1(24)	12948450	82	39	76	24	32	7	14	9	20	0	0.245	1.000	1.000
500	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(6), CANT1(4), CTPS2(1), DCK(1), DPYD(4), DPYS(21), DTYMK(1), DUT(1), ITPA(1), NME1(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3), RRM1(2), TYMS(1), UMPS(2), UPB1(2)	16190318	92	44	72	21	24	17	12	10	29	0	0.0910	1.000	1.000
501	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADL(2), ACADM(2), ACADS(1), ACADSB(3), ACAT1(2), ACOX1(1), ACOX3(2), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP4A22(2), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3)	13608163	69	21	69	14	25	17	9	7	11	0	0.00705	1.000	1.000
502	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(1), CITED2(1), CPT1B(5), CREBBP(3), DUT(1), EHHADH(1), EP300(6), HSD17B4(3), HSPA1A(1), LPL(4), ME1(2), MYC(2), NCOR1(9), NCOR2(5), NFKBIA(2), NR1H3(3), NR2F1(2), NRIP1(1), PIK3CA(6), PIK3R1(2), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTGS2(1), RB1(3), RELA(3), RXRA(1), SP1(1), STAT5A(2)	17770601	81	35	81	22	25	17	14	10	15	0	0.0920	1.000	1.000
503	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CAMK2D(1), CDK5(5), FYN(9), GNA11(3), GNAI1(1), GNB1(2), HRAS(1), JAK2(2), MAPK8(2), MAPT(3), MYLK(11), PLCG1(1), SHC1(2), SOS1(14), STAT1(3), STAT3(2), STAT5A(2), SYT1(1)	11679425	67	39	44	21	14	8	6	6	33	0	0.890	1.000	1.000
504	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD14(3), CD19(1), CD1A(2), CD1B(5), CD1C(2), CD1D(9), CD1E(1), CD2(2), CD22(2), CD33(3), CD34(1), CD38(2), CD3E(1), CD4(2), CD44(4), CD5(2), CD55(1), CD59(2), CD8B(2), CR1(5), CR2(10), CSF1(2), CSF1R(5), CSF2RA(1), CSF3(2), CSF3R(3), DNTT(4), EPO(2), EPOR(2), FCGR1A(1), FLT3(4), FLT3LG(1), GP5(2), GP9(2), HLA-DRB1(1), IL1B(1), IL1R2(9), IL2RA(1), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL7(1), IL7R(3), IL9R(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGAM(1), ITGB3(1), KIT(4), MME(2), MS4A1(4), THPO(1), TPO(7)	22817212	158	66	136	34	31	24	26	28	49	0	0.0318	1.000	1.000
505	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(1), ACTN2(4), BCAR1(2), BCR(2), CAPN1(1), CAPNS1(3), CAPNS2(2), CRKL(2), CSK(1), FYN(9), HRAS(1), ITGA1(7), MAPK8(2), PPP1R12B(1), PTK2(3), PXN(1), ROCK1(6), SHC1(2), SOS1(14), SRC(2), TLN1(11), VCL(3), ZYX(1)	13373182	85	40	66	12	22	19	6	7	31	0	0.00584	1.000	1.000
506	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(16), GTF2E1(1), GTF2E2(4), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3B(8), POLR3E(5), TAF5(1), TAF6(2), TAF9(2), TBP(3)	9712053	67	40	48	20	17	6	9	6	29	0	0.850	1.000	1.000
507	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(5), AMY2A(3), ENPP3(3), GAA(2), GANAB(4), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(3), HK2(3), HK3(4), MGAM(1), PGM1(1), PYGB(2), PYGL(2), PYGM(2), SI(5), UGDH(2), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1), UXS1(2)	15916563	79	41	73	22	26	16	10	10	17	0	0.246	1.000	1.000
508	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(4), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(3), CHAT(4), CHPT1(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), ESCO1(3), ESCO2(12), ETNK2(2), GNPAT(1), GPAM(4), GPD1(1), GPD2(1), LYPLA2(1), PCYT1A(2), PCYT1B(1), PHOSPHO1(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLD2(5), PPAP2B(2), PPAP2C(1), PTDSS1(3), PTDSS2(1), SH3GLB1(1)	18589272	94	47	81	27	24	12	15	13	30	0	0.322	1.000	1.000
509	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ADAM17(4), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(7), IGSF5(1), IKBKB(4), JAM2(2), LYN(1), MAP2K4(5), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NOD1(3), PAK1(19), PLCG1(1), PLCG2(7), PTPRZ1(4), RELA(3), SRC(2), TCIRG1(1), TJP1(6)	19697576	115	54	90	18	16	20	20	14	45	0	0.0259	1.000	1.000
510	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAD(1), BCL2L1(7), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(6), DFFB(1), FAS(3), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(3), PTPN13(8), TFG(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TRAF6(1)	12335638	68	28	56	20	14	13	12	6	23	0	0.649	1.000	1.000
511	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(17), CARS2(2), DARS(1), DARS2(2), EARS2(1), EPRS(1), FARS2(2), FARSA(2), FARSB(1), GARS(7), IARS(4), KARS(2), LARS2(2), MARS2(2), MTFMT(4), NARS2(2), PARS2(2), QARS(2), RARS(1), RARS2(4), SARS2(4), TARS(2), VARS(4), VARS2(3), WARS(2)	15067054	77	45	57	20	21	13	10	7	26	0	0.419	1.000	1.000
512	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), FUK(1), GMDS(1), GMPPA(5), HK1(3), HK2(3), HK3(4), HSD3B7(3), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(3), PFKL(2), PFKM(3), PFKP(1), PGM2(1), PHPT1(1), PMM2(2), RDH11(2), TPI1(3), TSTA3(1)	10476671	51	21	51	17	22	8	14	5	2	0	0.256	1.000	1.000
513	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(2), AKT3(4), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(2), CR2(10), CSK(1), DAG1(2), FLOT2(1), GSK3A(2), GSK3B(2), INPP5D(1), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), MAP4K1(3), NFATC1(4), NFATC2(10), PDK1(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), PLCG2(7), PPP1R13B(1), PPP3CA(3), PPP3CC(2), PTPRC(3), SHC1(2), SOS1(14), SOS2(1), SYK(2), VAV1(6)	20769047	140	61	114	25	38	21	12	19	49	1	0.00539	1.000	1.000
514	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AANAT(1), ACAT1(2), AFMID(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), AOX1(2), ASMT(2), CARM1(2), CAT(1), CYP1A1(2), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), INMT(1), KMO(2), KYNU(1), LCMT1(1), LCMT2(2), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(5), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), TDO2(1), TPH1(2), TPH2(2), WARS(2)	16901506	85	33	77	20	26	12	21	17	9	0	0.0485	1.000	1.000
515	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(3), BIRC2(2), CASP2(3), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CRADD(2), DAXX(6), DFFB(1), GSN(6), LMNB1(1), LMNB2(1), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK8(2), MDM2(2), NFKBIA(2), NUMA1(3), PAK2(3), PRKCD(11), PRKDC(9), PSEN1(1), PSEN2(1), PTK2(3), RASA1(4), RB1(3), RELA(3), SPTAN1(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1)	19615051	97	38	85	26	16	12	23	12	34	0	0.440	1.000	1.000
516	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(3), AKT2(2), AKT3(4), ANGPTL2(2), ARHGAP4(2), ARHGEF11(6), BTK(1), CDC42(1), GDI1(1), GDI2(3), INPPL1(5), ITPR1(10), ITPR2(12), ITPR3(10), LIMK1(1), MYLK(11), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDK1(1), PIK3CA(6), PIK3CD(2), PIK3CG(5), PIK3R1(2), PPP1R13B(1), PTEN(2), RACGAP1(3), ROCK1(6), ROCK2(2), SAG(1), WASF1(1), WASL(6)	19738833	142	71	113	35	35	20	18	15	54	0	0.254	1.000	1.000
517	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), AOX1(2), ASMT(2), CAT(1), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2D6(1), CYP2E1(3), CYP2F1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), CYP4B1(1), CYP51A1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2)	15316734	76	30	74	23	27	10	20	10	9	0	0.235	1.000	1.000
518	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(9), ASH2L(3), CARM1(2), CTCFL(1), DOT1L(1), EED(3), EHMT1(5), EHMT2(6), EZH1(1), EZH2(3), FBXO11(2), HCFC1(5), HSF4(1), KDM6A(8), MEN1(5), NSD1(7), OGT(2), PAXIP1(1), PPP1CA(1), PRDM2(8), PRDM9(5), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), RBBP5(1), SATB1(10), SETD1A(30), SETD2(9), SETD8(1), SETDB1(3), SETMAR(1), SMYD3(1), STK38(2), SUV39H2(3), SUV420H1(4), SUV420H2(2), SUZ12(2), WHSC1(4), WHSC1L1(8)	33760713	175	93	124	30	24	19	22	30	80	0	0.121	1.000	1.000
519	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(7), ACTN1(1), AKT1(3), AKT2(2), AKT3(4), ANGPTL2(2), ARHGEF6(2), ARHGEF7(9), BCAR1(2), BRAF(4), CDC42(1), CDKN2A(43), CRK(1), CSE1L(3), DOCK1(5), EPHB2(4), FYN(9), GRB7(3), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGB3BP(1), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MRAS(2), MYLK(11), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PIK3CA(6), PIK3CB(3), PKLR(2), PLCG1(1), PLCG2(7), PTEN(2), PTK2(3), ROCK1(6), ROCK2(2), SHC1(2), SOS1(14), SOS2(1), SRC(2), TERF2IP(1), TLN1(11), TLN2(6), ZYX(1)	34641760	267	107	202	49	60	40	26	30	111	0	0.00280	1.000	1.000
520	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BAD(1), CABIN1(6), CAMK4(2), CD3E(1), CD69(1), CREBBP(3), CSNK2A1(1), EGR2(3), EGR3(2), EP300(6), FCER1A(1), FOSL1(1), GATA3(3), GATA4(1), GSK3A(2), GSK3B(2), HRAS(1), IL1B(1), IL2RA(1), IL6(1), ITK(1), JUNB(1), KPNA5(1), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(2), MYF5(2), NCK2(2), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(6), OPRD1(2), P2RX7(2), PAK1(19), PPP3CC(2), PTPRC(3), RELA(3), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(6), VAV1(6), XPO5(2)	25599712	170	79	119	37	41	25	15	13	75	1	0.161	1.000	1.000
521	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(2), ACVR1C(2), AKT1(3), AKT2(2), AKT3(4), ARRB1(1), ARRB2(3), ATF4(1), BDNF(1), BRAF(4), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1D(35), CACNA1E(10), CACNA1F(2), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(6), CACNA2D2(2), CACNA2D3(3), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(3), CACNG3(3), CACNG4(1), CACNG5(2), CD14(3), CDC25B(2), CDC42(1), CHUK(1), CRK(1), CRKL(2), DAXX(6), DUSP10(1), DUSP14(1), DUSP16(2), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(1), ECSIT(7), EGF(4), EGFR(2), ELK1(2), ELK4(1), FAS(3), FASLG(1), FGF10(18), FGF12(1), FGF13(2), FGF14(2), FGF17(1), FGF18(1), FGF23(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(4), FLNA(10), FLNB(4), FLNC(12), HRAS(1), IKBKB(4), IL1B(1), IL1R2(9), JUND(1), KRAS(142), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP3K7(12), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(3), MAX(1), MEF2C(2), MKNK2(3), MOS(3), MRAS(2), MYC(2), NF1(6), NFATC2(10), NFATC4(5), NFKB2(1), NLK(2), NR4A1(3), NTF3(8), NTRK1(3), NTRK2(3), PAK1(19), PAK2(3), PDGFRA(3), PDGFRB(7), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), PTPN5(1), RAC2(1), RAP1B(3), RAPGEF2(6), RASA1(4), RASA2(2), RASGRF1(1), RASGRF2(7), RASGRP1(2), RASGRP2(1), RASGRP3(2), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS(2), SOS1(14), SOS2(1), SRF(1), STK3(1), STK4(3), STMN1(1), TAOK1(4), TAOK2(26), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), TNFRSF1A(2), TP53(119), TRAF2(1), TRAF6(1), ZAK(5)	82248269	852	178	542	133	183	146	155	88	275	5	9.66e-15	1.000	1.000
522	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(1), ACTN2(4), ACTN4(1), APC(8), APC2(2), ARAF(2), ARHGEF1(3), ARHGEF12(6), ARHGEF6(2), ARHGEF7(9), ARPC1A(2), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(4), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(4), CD14(3), CDC42(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CRK(1), CRKL(2), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH1(7), DIAPH2(1), DIAPH3(18), DOCK1(5), EGF(4), EGFR(2), FGD1(1), FGF10(18), FGF12(1), FGF13(2), FGF14(2), FGF17(1), FGF18(1), FGF23(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(4), FN1(9), GIT1(7), GSN(6), HRAS(1), IQGAP1(3), IQGAP2(1), IQGAP3(3), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(7), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), KRAS(142), LIMK1(1), LIMK2(2), MOS(3), MRAS(2), MYH10(38), MYH14(7), MYH9(4), MYL9(1), MYLK(11), MYLK2(4), NCKAP1(4), NCKAP1L(5), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(7), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PPP1R12B(1), PTK2(3), PXN(1), RAC2(1), RDX(4), RHOA(1), ROCK1(6), ROCK2(2), RRAS(2), SCIN(1), SOS1(14), SOS2(1), SSH1(4), SSH2(3), SSH3(1), TIAM1(10), TIAM2(5), VAV1(6), VCL(3), WASF1(1), WASF2(2), WASL(6)	78463302	628	172	374	124	118	129	136	55	188	2	3.60e-06	1.000	1.000
523	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(4), ARHGAP5(6), BAD(1), BCAR1(2), BIRC2(2), BRAF(4), CAPN2(1), CCND2(3), CCND3(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(5), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A4(13), COL4A6(6), COL5A1(25), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), COMP(4), CRK(1), CRKL(2), CTNNB1(9), DIAPH1(7), DOCK1(5), EGF(4), EGFR(2), ELK1(2), ERBB2(6), FARP2(3), FLNA(10), FLNB(4), FLNC(12), FLT1(4), FN1(9), FYN(9), GSK3B(2), HGF(1), HRAS(1), IBSP(3), IGF1R(6), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), KDR(1), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), MAPK10(1), MAPK8(2), MAPK9(1), MET(4), MYL9(1), MYLK(11), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PARVB(3), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(7), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTEN(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RELN(14), RHOA(1), ROCK1(6), ROCK2(2), SHC1(2), SHC2(2), SHC4(2), SOS1(14), SOS2(1), SRC(2), THBS1(7), THBS2(4), THBS3(1), THBS4(34), TLN1(11), TLN2(6), TNC(14), TNN(5), TNR(14), TNXB(13), VAV1(6), VCL(3), VEGFC(1), VTN(2), VWF(5), ZYX(1)	104580098	675	158	575	166	176	123	95	84	191	6	0.000673	1.000	1.000
524	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	ACTB(2), CHAD(1), COL11A1(7), COL11A2(5), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A4(13), COL4A6(6), COL5A1(25), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), COMP(4), DES(1), DSC1(5), DSC2(6), DSC3(6), DSG1(2), DSG2(3), DSG3(1), DSG4(5), FN1(9), GJA1(1), GJA10(1), GJA3(1), GJA4(2), GJA5(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJC3(2), GJD4(2), IBSP(3), INA(3), ITGA6(5), ITGB4(8), KRT1(2), KRT10(2), KRT12(3), KRT13(2), KRT14(2), KRT15(4), KRT16(1), KRT17(3), KRT19(1), KRT2(3), KRT20(3), KRT24(2), KRT25(1), KRT27(1), KRT28(2), KRT3(2), KRT31(2), KRT33A(2), KRT33B(1), KRT34(3), KRT37(1), KRT38(2), KRT39(2), KRT4(2), KRT40(1), KRT5(1), KRT6A(4), KRT6B(1), KRT7(3), KRT72(1), KRT73(14), KRT74(3), KRT75(1), KRT76(7), KRT77(2), KRT78(2), KRT79(2), KRT82(2), KRT83(4), KRT85(1), KRT86(2), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), LMNB1(1), LMNB2(1), NES(7), PRPH(1), RELN(14), THBS1(7), THBS2(4), THBS3(1), THBS4(34), TNC(14), TNN(5), TNR(14), TNXB(13), VTN(2), VWF(5)	70230241	509	143	438	137	151	78	82	59	135	4	0.0176	1.000	1.000
525	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	169	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY7(2), ADCY8(4), ADCY9(5), ADORA2A(1), ADRA1A(4), ADRA1D(1), ADRB2(1), ATP2A1(6), ATP2A2(3), ATP2B1(7), ATP2B2(7), ATP2B3(7), ATP2B4(2), AVPR1A(1), AVPR1B(1), BDKRB1(1), BDKRB2(1), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1D(35), CACNA1E(10), CACNA1F(2), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(6), CALML3(1), CALML6(2), CAMK2D(1), CAMK4(2), CCKAR(8), CCKBR(3), CD38(2), CHRM1(1), CHRM2(3), CHRM3(2), CHRM5(3), CHRNA7(1), CYSLTR2(1), DRD1(5), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(6), ERBB4(6), GNA11(3), GNA14(1), GNA15(4), GNAL(3), GNAQ(1), GNAS(16), GRIN1(8), GRIN2A(7), GRIN2C(6), GRIN2D(5), GRM1(17), GRM5(7), GRPR(1), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(5), HTR7(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), LHCGR(2), LTB4R2(1), MYLK(11), MYLK2(4), NOS1(10), NOS3(9), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(2), PDE1B(2), PDE1C(1), PDGFRA(3), PDGFRB(7), PHKA2(7), PHKB(4), PHKG1(2), PHKG2(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PLCZ1(5), PPID(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), PTGER3(1), PTGFR(2), RYR1(24), RYR2(26), RYR3(23), SLC25A4(1), SLC25A5(1), SLC25A6(3), SLC8A1(2), SLC8A2(4), SLC8A3(5), SPHK1(1), SPHK2(1), TACR1(3), TACR2(1), TACR3(4), TBXA2R(1), TNNC1(2), TNNC2(1), TRHR(2), TRPC1(3), VDAC1(7), VDAC2(1)	77255500	601	143	516	159	215	75	102	72	133	4	0.000279	1.000	1.000
526	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1B(2), ACVR2A(9), AMH(2), AMHR2(5), BMP2(3), BMP7(2), BMPR1A(4), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(2), CCL26(1), CCL27(1), CCL3(1), CCL7(1), CCL8(1), CCR1(2), CCR2(1), CCR3(11), CCR4(4), CCR7(1), CCR9(1), CD40(1), CRLF2(1), CSF1(2), CSF1R(5), CSF2RA(1), CSF2RB(2), CSF3(2), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCR4(3), EDA(1), EDA2R(2), EDAR(2), EGF(4), EGFR(2), EPO(2), EPOR(2), FAS(3), FASLG(1), FLT1(4), FLT3(4), FLT3LG(1), FLT4(11), GDF5(2), GHR(1), HGF(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNGR2(17), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL17RA(3), IL18R1(1), IL18RAP(3), IL1B(1), IL1R2(9), IL1RAP(2), IL20RA(2), IL21(2), IL21R(1), IL22RA1(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL6ST(4), IL7(1), IL7R(3), IL9(1), IL9R(1), INHBA(2), INHBB(2), INHBC(1), KDR(1), KIT(4), LEPR(7), LIF(2), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(3), PDGFC(2), PDGFRA(3), PDGFRB(7), PF4V1(1), PLEKHO2(1), PRL(4), PRLR(2), RELT(1), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(5), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF8(2), TNFRSF9(7), TNFSF12(2), TNFSF13(2), TNFSF14(1), TNFSF18(1), TNFSF8(3), TNFSF9(28), TPO(7), TSLP(1), VEGFC(1), XCR1(3)	49861461	366	127	287	71	83	58	44	43	137	1	0.000631	1.000	1.000
527	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(2), CD44(4), CHAD(1), COL11A1(7), COL11A2(5), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A4(13), COL4A6(6), COL5A1(25), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), DAG1(2), FN1(9), FNDC1(9), FNDC3A(3), GP5(2), GP6(1), GP9(2), HMMR(11), HSPG2(3), IBSP(3), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), RELN(14), SDC3(1), SDC4(2), SV2A(5), SV2C(1), THBS1(7), THBS2(4), THBS3(1), THBS4(34), TNC(14), TNN(5), TNR(14), TNXB(13), VTN(2), VWF(5)	63436959	423	127	358	108	105	75	71	50	118	4	0.0241	1.000	1.000
528	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADRA1A(4), ADRA1D(1), ADRB2(1), ANXA6(3), ARRB1(1), ARRB2(3), ATP1A4(4), ATP1B3(1), ATP2A2(3), ATP2B1(7), ATP2B2(7), ATP2B3(7), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1D(35), CACNA1E(10), CACNA1S(6), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), GJA1(1), GJA4(2), GJA5(1), GJB1(1), GJB4(1), GJB6(2), GNA11(3), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK4(2), GRK5(4), GRK6(1), ITPR1(10), ITPR2(12), ITPR3(10), KCNB1(9), KCNJ5(1), MIB1(3), NME7(1), PLCB3(4), PRKACB(1), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCQ(3), PRKD1(1), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(2), RGS7(2), RGS9(4), RYR1(24), RYR2(26), RYR3(23), SLC8A1(2), SLC8A3(5), USP5(2), YWHAH(1)	53360125	382	124	321	117	128	57	57	36	100	4	0.0998	1.000	1.000
529	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	238	ADORA2A(1), ADORA3(5), ADRA1A(4), ADRA2A(1), ADRA2B(4), ADRA2C(3), ADRB2(1), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), C5AR1(1), CALCR(2), CCKAR(8), CCKBR(3), CGA(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CRHR1(2), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(5), DRD3(1), DRD5(5), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHB(1), FSHR(4), GABBR1(18), GABBR2(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GABRB1(3), GABRB2(2), GABRB3(5), GABRD(7), GABRE(3), GABRG1(1), GABRG2(1), GABRG3(2), GABRP(1), GABRQ(2), GABRR2(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GIPR(2), GLP2R(3), GLRA1(3), GLRA2(3), GLRB(1), GNRHR(1), GPR156(2), GPR35(1), GPR50(2), GPR83(1), GRIA1(3), GRIA2(1), GRIA4(2), GRID1(7), GRID2(10), GRIK1(1), GRIK2(9), GRIK3(4), GRIK4(2), GRIK5(2), GRIN1(8), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRIN3A(4), GRIN3B(5), GRM1(17), GRM2(5), GRM3(3), GRM4(4), GRM5(7), GRM6(7), GRM7(5), GRM8(5), GRPR(1), HCRTR1(2), HCRTR2(5), HRH2(2), HRH3(1), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(5), HTR7(1), LEPR(7), LHB(2), LHCGR(2), LTB4R(7), LTB4R2(1), MC2R(2), MC3R(4), MC5R(3), MCHR1(3), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(3), NMBR(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR1(1), NPFFR2(1), NPY1R(3), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(2), P2RY1(7), P2RY13(2), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(7), PRL(4), PRLR(2), PRSS1(7), PRSS3(1), PTGDR(2), PTGER3(1), PTGFR(2), RXFP1(1), SSTR1(4), SSTR3(2), SSTR4(3), SSTR5(5), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(2), TAAR8(3), TACR1(3), TACR2(1), TACR3(4), TBXA2R(1), THRA(5), THRB(1), TRHR(2), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1)	62644830	502	120	451	138	171	77	91	68	94	1	0.000107	1.000	1.000
530	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(2), ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADM(1), ARRB1(1), ARRB2(3), ATF1(1), ATF3(1), ATF4(1), ATF5(1), ATP2A2(3), CALCA(2), CAMK2D(1), CNN2(1), CORIN(3), CRHR1(2), DGKZ(3), ETS2(2), GABPA(2), GABPB2(1), GBA2(3), GJA1(1), GNAQ(1), GNB1(2), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK4(2), GRK5(4), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(2), IL1B(1), IL6(1), ITPR1(10), ITPR2(12), ITPR3(10), MAFF(2), MIB1(3), MYLK2(4), NOS1(10), NOS3(9), OXTR(2), PDE4D(2), PLCB3(4), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCD(11), PRKCE(1), PRKCH(6), PRKCQ(3), PRKD1(1), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(2), RGS7(2), RGS9(4), RYR1(24), RYR2(26), RYR3(23), SLC8A1(2), SP1(1), TNXB(13), USP5(2), YWHAH(1)	49169188	305	113	276	104	107	44	50	35	67	2	0.281	1.000	1.000
531	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(3), CADM3(3), CD2(2), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(2), CD6(1), CD80(1), CD86(5), CD8B(2), CDH1(1), CDH15(4), CDH2(5), CDH3(14), CDH4(5), CDH5(2), CLDN17(1), CLDN3(2), CLDN9(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(8), ESAM(1), F11R(1), GLG1(2), HLA-A(7), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(3), ICAM1(2), ICAM3(2), ICOSLG(1), ITGA4(1), ITGA6(5), ITGA8(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGB2(1), ITGB8(3), JAM2(2), L1CAM(6), MPZL1(1), NCAM1(3), NCAM2(5), NEGR1(2), NEO1(3), NFASC(5), NLGN1(5), NLGN2(3), NLGN3(5), NRCAM(2), NRXN1(4), NRXN2(7), NRXN3(4), PDCD1(1), PTPRC(3), PTPRF(28), PTPRM(6), PVRL1(19), PVRL2(1), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELL(1), SELP(3), SIGLEC1(12), VCAN(10)	41565916	273	103	217	88	76	36	39	35	87	0	0.355	1.000	1.000
532	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(2), AKT3(4), BCL2L1(7), CBL(5), CBLB(2), CBLC(1), CCND2(3), CCND3(1), CISH(1), CREBBP(3), CRLF2(1), CSF2RA(1), CSF2RB(2), CSF3(2), CSF3R(3), EP300(6), EPO(2), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNGR2(17), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL20RA(2), IL21(2), IL21R(1), IL22RA1(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL6ST(4), IL7(1), IL7R(3), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(7), LIF(2), LIFR(5), MYC(2), OSMR(3), PIAS1(2), PIAS2(3), PIAS3(2), PIAS4(3), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PRL(4), PRLR(2), PTPN6(4), SOCS4(3), SOCS5(4), SOCS7(1), SOS1(14), SOS2(1), SPRED1(1), SPRED2(1), SPRY4(5), STAM(6), STAM2(1), STAT1(3), STAT2(2), STAT3(2), STAT4(1), STAT5A(2), STAT6(5), TPO(7), TSLP(1), TYK2(2)	40624239	250	100	205	69	61	33	33	35	88	0	0.373	1.000	1.000
533	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(5), AMY2A(3), ASCC3(5), ATP13A2(2), DDX18(1), DDX23(1), DDX4(6), DDX41(2), DDX47(5), DDX50(7), DDX51(1), DDX54(2), DDX55(1), DDX56(2), DHX58(4), ENPP3(3), EP400(8), ERCC2(2), ERCC3(16), G6PC2(1), GAA(2), GANC(1), GBA(4), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(3), HK2(3), HK3(4), IFIH1(7), MGAM(1), MOV10L1(6), NUDT8(1), PGM1(1), PYGB(2), PYGL(2), PYGM(2), RAD54L(5), RUVBL2(4), SETX(6), SI(5), SKIV2L2(1), SMARCA2(10), SMARCA5(1), UGDH(2), UGP2(6), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), UXS1(2)	34622393	202	90	168	73	47	34	28	27	65	1	0.951	1.000	1.000
534	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	164	ADORA2A(1), ADORA3(5), ADRA1A(4), ADRA1D(1), ADRA2A(1), ADRA2C(3), ADRB2(1), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKAR(8), CCKBR(3), CCR1(2), CCR10(2), CCR2(1), CCR3(11), CCR4(4), CCR7(1), CCR9(1), CCRL2(2), CHML(5), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CMKLR1(1), CX3CR1(1), CXCR4(3), DRD1(5), DRD3(1), DRD5(5), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHR(4), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR35(1), GPR4(2), GPR50(2), GPR6(1), GPR83(1), GPR87(1), GRPR(1), HCRTR1(2), HCRTR2(5), HRH2(2), HRH3(1), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(5), HTR7(1), LHCGR(2), LTB4R(7), MC3R(4), MC5R(3), MLNR(1), MTNR1A(1), MTNR1B(3), NMBR(1), NMUR1(1), NMUR2(3), NPY1R(3), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OR10A5(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(2), P2RY1(7), P2RY12(1), P2RY13(2), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(2), RGR(1), RRH(1), SSTR1(4), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(2)	34332494	238	89	215	70	74	35	59	34	35	1	0.0143	1.000	1.000
535	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADSL(2), ADSS(3), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(4), AMPD2(2), AMPD3(4), APRT(1), ATIC(2), CANT1(4), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GART(1), GMPR(3), GMPR2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IMPDH1(3), ITPA(1), NME1(1), NME4(1), NME7(1), NPR1(5), NPR2(1), NT5C1B(3), NT5C2(6), NT5E(1), NT5M(1), NUDT2(1), NUDT9(4), PAICS(2), PAPSS1(2), PAPSS2(4), PDE10A(9), PDE11A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4C(2), PDE4D(2), PDE5A(3), PDE6G(1), PDE7B(1), PDE8A(2), PDE8B(3), PDE9A(1), PFAS(7), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), POLR3B(8), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RRM1(2), RRM2B(1), XDH(5)	45976311	240	88	223	69	81	40	34	40	43	2	0.0549	1.000	1.000
536	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(4), BCAR1(2), CAPN1(1), CAPN11(1), CAPN2(1), CAPN3(4), CAPN5(3), CAPN6(6), CAPN9(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(5), FYN(9), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(7), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), MAP2K3(1), MAP2K6(3), MAPK10(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PIK3R2(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), ROCK1(6), ROCK2(2), SDCCAG8(2), SEPP1(1), SHC1(2), SORBS1(1), SOS1(14), SRC(2), TLN1(11), TNS1(4), VCL(3), ZYX(1)	37978960	210	81	166	48	47	36	31	18	78	0	0.0527	1.000	1.000
537	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(4), CHUK(1), CREB1(2), DAXX(6), ELK1(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP3K7(12), MAP3K9(4), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK4(1), MAPK6(2), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(2), MEF2C(2), MEF2D(2), MKNK2(3), MYC(2), NFKBIA(2), PAK1(19), PAK2(3), RELA(3), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), RPS6KA5(4), RPS6KB2(4), SHC1(2), SP1(1), STAT1(3), TGFB1(1), TGFB2(2), TGFBR1(8), TRADD(1), TRAF2(1)	27300625	169	80	135	44	33	27	25	12	72	0	0.498	1.000	1.000
538	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(3), ABCA12(14), ABCA13(13), ABCA2(6), ABCA3(7), ABCA4(8), ABCA5(8), ABCA6(6), ABCA7(7), ABCA8(6), ABCA9(10), ABCB1(7), ABCB10(2), ABCB11(4), ABCB4(9), ABCB5(7), ABCB6(4), ABCB8(1), ABCC1(1), ABCC10(5), ABCC11(3), ABCC12(5), ABCC2(20), ABCC3(5), ABCC4(5), ABCC5(4), ABCC6(6), ABCC8(1), ABCC9(3), ABCD1(1), ABCD2(2), ABCD3(1), ABCG1(3), ABCG2(1), ABCG4(4), ABCG5(3), ABCG8(2), CFTR(5), TAP1(4), TAP2(1)	33256320	213	78	185	52	55	39	24	37	55	3	0.0160	1.000	1.000
539	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML3(1), CALML6(2), CDIPT(3), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(1), INPP5E(2), INPPL1(5), ITPK1(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), OCRL(1), PI4KA(4), PI4KB(2), PIK3C2A(5), PIK3C2B(12), PIK3C3(2), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PLCZ1(5), PRKCG(2), PTEN(2), SYNJ1(2), SYNJ2(3)	35337932	185	74	171	48	56	25	24	25	55	0	0.0414	1.000	1.000
540	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(2), ACTN2(4), ACTN4(1), DES(1), DMD(11), MYBPC1(4), MYBPC2(1), MYBPC3(3), MYH3(2), MYH6(7), MYH7(8), MYH8(6), MYL1(1), MYL3(3), MYL9(1), MYOM1(4), NEB(21), TMOD1(1), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(4), TNNT2(3), TNNT3(1), TPM1(1), TPM3(1), TTN(116)	38480061	214	74	211	64	59	46	48	26	33	2	0.294	1.000	1.000
541	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK2(1), CLK3(3), CLK4(2), COL2A1(5), CPSF1(4), CPSF2(4), CPSF3(5), CPSF4(2), CSTF1(1), CSTF2(1), CSTF2T(1), CSTF3(4), DDX20(1), DHX15(4), DHX16(4), DHX38(2), DHX8(3), DHX9(14), DICER1(10), FUS(2), LSM2(1), METTL3(2), NCBP2(2), NONO(1), NUDT21(1), PABPN1(2), PAPOLA(2), PHF5A(2), POLR2A(6), PPM1G(2), PRPF3(3), PRPF4(3), PRPF4B(1), PRPF8(9), PTBP1(3), PTBP2(1), RBM17(1), RBM5(1), RNGTT(4), SF3A2(1), SF3B1(4), SF3B2(3), SF3B5(1), SNRPA(1), SNRPB(1), SNRPE(3), SNRPN(2), SPOP(1), SRPK1(2), SRRM1(4), SUPT5H(2), U2AF1(3), U2AF2(3), XRN2(4)	29558180	155	73	132	33	47	23	19	23	42	1	0.0666	1.000	1.000
542	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	A4GNT(1), ALG10(1), ALG10B(2), ALG11(3), ALG12(4), ALG13(2), ALG9(1), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT2(16), B4GALT5(2), CHPF(2), CHST1(1), CHST11(3), CHST12(1), CHST14(3), CHST2(2), CHST4(1), CHST6(4), CHSY1(2), DDOST(1), DPAGT1(8), EXT1(2), EXT2(4), EXTL1(3), EXTL2(2), EXTL3(6), GALNT1(3), GALNT10(6), GALNT13(2), GALNT14(1), GALNT2(2), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GANAB(4), GCNT4(1), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(5), MGAT3(3), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(3), NDST3(3), NDST4(3), OGT(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), WBSCR17(2), XYLT1(5), XYLT2(7)	31343199	173	68	148	42	51	28	32	16	46	0	0.0456	1.000	1.000
543	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(1), BDKRB1(1), BDKRB2(1), C1QA(1), C1QB(1), C1QC(1), C1R(1), C1S(6), C2(6), C3(11), C3AR1(2), C5(2), C5AR1(1), C6(6), C7(4), C8A(5), C9(3), CD46(1), CD55(1), CD59(2), CFB(3), CFD(1), CFH(6), CFI(3), CR1(5), CR2(10), F10(4), F11(1), F12(3), F13A1(3), F13B(2), F5(14), F8(9), FGA(6), FGB(4), FGG(2), KLKB1(2), KNG1(2), MASP1(2), PLAT(2), PLAUR(10), PLG(1), PROC(1), PROS1(2), SERPINA1(2), SERPINA5(2), SERPINC1(3), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(2), THBD(3), VWF(5)	25265476	177	68	154	45	38	27	32	32	47	1	0.0990	1.000	1.000
544	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(2), ACVRL1(1), AKT1(3), BMPR1A(4), BMPR2(3), BUB1(2), CDIPT(3), CDKL1(1), CLK1(3), CLK2(1), CLK4(2), COL4A3BP(1), CSNK2A1(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MAP3K10(4), MOS(3), OCRL(1), PAK4(2), PIK3C2A(5), PIK3C2B(12), PIK3CA(6), PIK3CB(3), PIK3CG(5), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCQ(3), PRKD1(1), PRKG1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), STK11(4), TGFBR1(8), VRK1(1)	32080599	174	68	160	45	53	25	22	25	49	0	0.0983	1.000	1.000
545	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADSL(2), ADSS(3), AK2(1), ALLC(2), AMPD1(4), AMPD2(2), AMPD3(4), APRT(1), ATIC(2), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), CANT1(4), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), FHIT(1), GART(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IMPDH1(3), ITPA(1), NME1(1), NPR1(5), NPR2(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(2), PAPSS2(4), PDE4A(2), PDE4C(2), PDE4D(2), PDE5A(3), PDE6B(3), PDE6C(1), PDE6G(1), PDE7B(1), PDE8A(2), PDE9A(1), PFAS(7), PKLR(2), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(3), PRPS2(1), RRM1(2)	36160083	186	68	180	47	69	38	28	19	30	2	0.00429	1.000	1.000
546	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(3), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMP8A(1), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(1), CSNK1G3(11), DHH(2), FBXW11(2), GLI1(6), GLI2(5), GLI3(14), GSK3B(2), HHIP(5), LRP2(10), PRKACB(1), PRKACG(3), PTCH1(6), PTCH2(8), SMO(2), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(7), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1), ZIC2(5)	17335283	137	67	122	40	52	25	17	11	32	0	0.133	1.000	1.000
547	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	59	APC(8), AXIN1(4), CCND2(3), CCND3(1), CSNK1E(1), CTNNB1(9), DVL1(4), DVL2(4), DVL3(2), FBXW2(2), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GSK3B(2), LDLR(1), MAPK10(1), MAPK9(1), MYC(2), PAFAH1B1(1), PPP2R5C(6), PPP2R5E(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCI(3), PRKCQ(3), PRKD1(1), RHOA(1), SFRP4(1), TCF7(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(7), WNT2B(3), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2)	17099740	132	67	114	36	49	25	11	17	30	0	0.0409	1.000	1.000
548	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(8), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADIPOR1(2), AKT1(3), AKT2(2), AKT3(4), CHUK(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(4), IRS1(30), IRS2(4), IRS4(4), JAK1(1), JAK2(2), JAK3(3), LEPR(7), MAPK10(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NPY(2), PCK1(3), PCK2(5), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(4), PRKCQ(3), RELA(3), RXRA(1), RXRB(1), RXRG(1), SLC2A1(3), STAT3(2), STK11(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2)	23494551	155	66	128	49	38	27	19	16	54	1	0.505	1.000	1.000
549	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(2), AKT3(4), CASP8(2), CCL3(1), CD14(3), CD40(1), CD80(1), CD86(5), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IKBKB(4), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(1), IRF5(1), IRF7(2), LBP(1), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K7(12), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), RELA(3), STAT1(3), TBK1(1), TICAM1(2), TLR1(5), TLR2(2), TLR3(3), TLR4(1), TLR5(3), TLR6(4), TLR8(2), TLR9(5), TRAF6(1)	25163917	140	63	123	35	35	19	22	20	44	0	0.0953	1.000	1.000
550	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AK3(1), CAD(6), CANT1(4), CTPS2(1), DCK(1), DPYD(4), DPYS(21), DTYMK(1), DUT(1), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME7(1), NT5C1B(3), NT5C2(6), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), POLR3B(8), PRIM1(1), RRM1(2), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(2)	22769591	126	60	98	31	27	18	19	24	38	0	0.203	1.000	1.000
551	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), ASCC3(5), ATP13A2(2), DDX18(1), DDX23(1), DDX4(6), DDX41(2), DDX47(5), DDX50(7), DDX51(1), DDX54(2), DDX55(1), DDX56(2), DHFR(1), DHX58(4), EP400(8), ERCC2(2), ERCC3(16), FPGS(3), GCH1(1), GGH(2), IFIH1(7), MOV10L1(6), NUDT8(1), QDPR(2), RAD54L(5), RUVBL2(4), SETX(6), SKIV2L2(1), SMARCA2(10), SMARCA5(1)	17653995	129	60	103	53	25	23	16	15	49	1	0.988	1.000	1.000
552	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(6), BCAR1(2), CDC42(1), CDH5(2), CLDN17(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTNND1(3), CXCR4(3), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(2), ITGA4(1), ITGAL(3), ITGAM(1), ITGB2(1), ITK(1), JAM2(2), MAPK11(1), MAPK12(1), MAPK13(1), MLLT4(5), MMP2(2), MMP9(4), MYL9(1), NCF2(1), NCF4(1), NOX1(4), NOX3(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RAPGEF3(4), RAPGEF4(3), RHOA(1), RHOH(2), ROCK1(6), ROCK2(2), SIPA1(3), THY1(1), TXK(1), VAV1(6), VCL(3)	35143000	166	58	163	61	54	33	19	26	31	3	0.414	1.000	1.000
553	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ASAH1(1), ATF1(1), BRAF(4), CAMP(2), CREB1(2), CREB5(1), CREBBP(3), CRKL(2), DAG1(2), EGR1(23), EGR2(3), EGR3(2), ELK1(2), FRS2(1), GNAQ(1), MAP1B(7), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), NTRK1(3), OPN1LW(2), PIK3CA(6), PIK3CD(2), PIK3R1(2), SHC1(2), SRC(2), TERF2IP(1), TH(1)	14731938	101	57	82	31	23	11	14	11	42	0	0.660	1.000	1.000
554	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(8), ATP4A(24), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7A2(1), COX7B2(2), COX7C(1), COX8C(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(3), NDUFV2(3), SDHA(6), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1), UQCRH(2)	15677355	110	55	86	31	21	19	14	15	40	1	0.639	1.000	1.000
555	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(5), CCKBR(3), CCR2(1), CCR3(11), CELSR1(5), CELSR2(11), CELSR3(12), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(3), EMR3(1), FSHR(4), GHRHR(1), GNRHR(1), GPR116(3), GPR132(1), GPR133(9), GPR135(1), GPR143(1), GPR18(2), GPR56(1), GPR61(1), GPR84(1), GRM1(17), GRPR(1), LGR6(3), LPHN2(10), LPHN3(1), LTB4R2(1), OR2M4(3), P2RY13(2), PTGFR(2), SMO(2), TAAR5(2), TSHR(3)	18818404	131	53	115	41	44	20	21	16	29	1	0.122	1.000	1.000
556	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(2), INPPL1(5), ISYNA1(1), ITPK1(1), ITPKB(3), MINPP1(1), MIOX(1), OCRL(1), PI4KA(4), PI4KB(2), PIK3C3(2), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PLCZ1(5), PTEN(2), SYNJ1(2), SYNJ2(3)	20987328	95	44	89	31	25	14	14	15	27	0	0.397	1.000	1.000
557	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1A1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CEL(14), DGAT1(3), DGAT2(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), GK2(5), GLB1(2), GPAM(4), LCT(6), LIPA(1), LIPF(2), LIPG(4), LPL(4), MGLL(2), PNLIP(2), PPAP2B(2), PPAP2C(1)	16553271	109	43	99	31	36	18	12	11	32	0	0.111	1.000	1.000
558	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(10), B3GALT4(2), CDR1(2), DGKI(5), IL6ST(4), RPL10(3), RPL11(1), RPL12(1), RPL14(1), RPL15(2), RPL18(2), RPL18A(1), RPL19(1), RPL24(1), RPL28(3), RPL32(2), RPL34(1), RPL35(1), RPL36(1), RPL3L(2), RPL4(3), RPL7A(2), RPLP0(1), RPLP2(1), RPS11(2), RPS25(2), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5), RPS6KB2(4), RPSA(1), SLC36A2(1), TBC1D10C(3), TSPAN9(1), UBB(1), UBC(2)	14730832	82	43	77	56	15	11	17	8	30	1	1.000	1.000	1.000
559	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(2), AKT3(4), BRAF(4), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PRKAA1(1), PRKAA2(1), RICTOR(6), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5), RPS6KB2(4), STK11(4), TSC1(1), TSC2(8), ULK1(3), ULK3(1), VEGFC(1)	15088870	84	41	78	26	22	16	11	7	28	0	0.563	1.000	1.000
560	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(4), APH1A(3), CREBBP(3), CTBP2(3), DLL4(2), DTX1(3), DTX2(5), DVL1(4), DVL2(4), DVL3(2), EP300(6), JAG1(2), JAG2(3), LFNG(1), MAML1(5), MAML2(3), MAML3(17), NCOR2(5), NOTCH1(10), NOTCH2(4), NOTCH3(7), NOTCH4(5), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RBPJL(1), SNW1(1)	20114108	109	40	94	69	31	26	18	10	24	0	0.999	1.000	1.000
561	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(3), CDC7(1), CDT1(1), DIAPH2(1), MCM10(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), NACA(13), PCNA(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), PRIM1(1), RFC1(4), RFC2(2), RFC3(1), RPA1(1), RPA2(3), RPA3(2), RPS27A(1), UBB(1), UBC(2)	14211732	76	34	73	42	25	11	15	12	11	2	0.993	1.000	1.000
562	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BAD(1), BRAF(4), CREB1(2), CREB5(1), DUSP6(2), DUSP9(1), MKNK2(3), MOS(3), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS1(14), SOS2(1)	8322265	39	34	27	14	7	4	4	2	22	0	0.973	1.000	1.000
563	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(1), CBR3(5), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2J2(4), CYP2U1(1), CYP4A22(2), CYP4F2(2), CYP4F3(4), DHRS4(4), EPHX2(1), GGT1(1), GPX5(4), GPX6(1), LTA4H(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1)	10953036	64	32	54	29	19	9	13	3	19	1	0.910	1.000	1.000
564	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(16), GTF2A1(1), GTF2E1(1), GTF2F1(6), NCOA2(3), NCOA3(3), NCOR2(5), POLR2A(6), RXRA(1), TBP(3)	7062938	45	31	30	25	8	3	6	2	25	1	1.000	1.000	1.000
565	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CBR3(5), CYP4F2(2), CYP4F3(4), EPX(4), GGT1(1), LPO(6), LTA4H(2), MPO(2), PLA2G3(2), PLA2G6(4), PRDX1(1), PRDX2(1), PRDX5(2), PTGDS(2), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1), TPO(7)	7829592	56	28	48	22	20	5	11	3	16	1	0.822	1.000	1.000
566	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ARRB2(3), CALML3(1), CALML6(2), CAMK2D(1), CLCA1(2), CLCA2(2), CLCA4(2), CNGA3(4), CNGA4(2), CNGB1(11), GNAL(3), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDC(1), PDE1C(1), PRKACB(1), PRKACG(3), PRKG1(1), PRKG2(2)	8538815	52	27	44	19	15	9	12	5	11	0	0.648	1.000	1.000
567	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(2), ALAS2(3), AOC2(3), AOC3(3), CHDH(2), DAO(2), DMGDH(4), GARS(7), GLDC(1), HSD3B7(3), PHGDH(2), PSAT1(2), RDH11(2), SARDH(3), SARS2(4), SHMT1(2), SHMT2(4), TARS(2)	12057914	53	25	48	20	29	12	5	5	2	0	0.352	1.000	1.000
568	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(2), ALAS2(3), AOC2(3), AOC3(3), ATP6V0C(1), CHDH(2), CPT1B(5), DAO(2), DMGDH(4), GARS(7), GLDC(1), PLCB2(5), PLCG1(1), PLCG2(7), SARDH(3), SHMT1(2), SHMT2(4), TARS(2)	11867513	59	24	57	21	26	14	8	5	6	0	0.314	1.000	1.000
569	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(3), B3GAT3(2), CHPF(2), CHST11(3), CHST12(1), CHST14(3), CHSY1(2), DSE(4), XYLT1(5), XYLT2(7)	4206947	32	23	29	13	13	4	7	2	6	0	0.577	1.000	1.000
570	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(4), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(2), LCT(6), MAN2B1(2), MAN2B2(2), MANBA(2), NAGLU(2), NEU4(2)	9841351	43	22	42	19	12	7	8	3	13	0	0.782	1.000	1.000
571	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(2), HRAS(1), IL6(1), IL6R(1), IL6ST(4), JAK1(1), JAK2(2), JAK3(3), SHC1(2), SOS1(14), SRF(1), STAT3(2)	6752518	35	21	24	16	5	4	3	3	20	0	0.987	1.000	1.000
572	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(2), CD97(2), CRHR1(2), CRHR2(1), ELTD1(5), EMR1(3), EMR2(3), GHRHR(1), GIPR(2), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(10), LPHN3(1), VIPR1(1), VIPR2(1)	7558705	41	19	41	17	9	9	5	11	7	0	0.542	1.000	1.000
573	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), DNMT3A(8), DNMT3B(5), MARS2(2), MTFMT(4), MTR(7), TAT(1)	5793794	30	19	24	16	7	5	5	2	10	1	0.936	1.000	1.000
574	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), POLR3B(8)	6485860	30	19	27	11	12	4	4	6	4	0	0.562	1.000	1.000
575	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(1), GSK3B(2), IGF1R(6), INPPL1(5), PDK2(3), PIK3CA(6), PIK3R1(2), PPP2CA(1), PTEN(2)	5508889	31	19	28	10	6	5	4	6	10	0	0.643	1.000	1.000
576	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(2), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ATP6V0C(1), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(6), GCDH(2), HADHA(1), PLOD1(2), SHMT1(2), SHMT2(4), TMLHE(1)	10380977	40	18	36	18	13	9	11	0	7	0	0.715	1.000	1.000
577	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10A(1), RPL10L(2), RPL11(1), RPL12(1), RPL14(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL24(1), RPL28(3), RPL32(2), RPL34(1), RPL35(1), RPL36A(2), RPL36AL(1), RPL3L(2), RPS11(2), RPS25(2), RPS27(1), RPS28(1), RPSA(1)	6369092	32	17	31	11	9	3	9	0	11	0	0.796	1.000	1.000
578	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(4), CHAT(4), DBH(1), DDC(1), GAD1(6), GAD2(5), HDC(1), PAH(1), SLC18A3(3), TH(1), TPH1(2)	4094886	30	16	30	13	11	2	9	2	5	1	0.596	1.000	1.000
579	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(4), GLB1(2), LCT(6), NEU4(2), PPAP2B(2), PPAP2C(1), SMPD1(1), SPTLC1(3), SPTLC2(1), UGCG(1)	6862460	32	16	32	12	11	9	3	2	7	0	0.283	1.000	1.000
580	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), CREB1(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), PIK3CA(6), PIK3R1(2), RB1(3), RELA(3), SP1(1)	5437899	27	16	26	10	4	2	7	5	9	0	0.872	1.000	1.000
581	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(3), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(2), GNPDA1(2), GNPDA2(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(4), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PHPT1(1), RENBP(1)	8020922	37	16	37	15	17	4	8	4	4	0	0.674	1.000	1.000
582	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(4), GPX6(1), GSR(1), GSS(1), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), OPLAH(3)	6374895	38	15	34	16	8	9	7	3	11	0	0.649	1.000	1.000
583	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(2), C6(6), C7(4), ICAM1(2), IL6(1), ITGA4(1), ITGAL(3), ITGB2(1), SELP(3)	6874289	34	15	34	14	10	8	5	2	9	0	0.533	1.000	1.000
584	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), DNMT3A(8), DNMT3B(5), MARS2(2), MTR(7)	4854061	24	15	21	14	7	4	5	2	5	1	0.901	1.000	1.000
585	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(3), GNAQ(1), GNB1(2), MYLK(11), PLCB1(1), PPP1R12B(1), ROCK1(6)	5762081	31	15	31	12	6	9	4	5	6	1	0.653	1.000	1.000
586	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(1), EPRS(1), FARS2(2), GARS(7), IARS(4), KARS(2), LARS2(2), MARS2(2), QARS(2), RARS(1), TARS(2), WARS(2)	8839491	29	14	27	10	9	7	6	5	2	0	0.542	1.000	1.000
587	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(4), GSS(1), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), PGD(1)	5149499	32	14	28	13	6	7	4	4	11	0	0.691	1.000	1.000
588	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(2), LCT(6), NAGLU(2)	5827840	26	14	25	16	5	7	3	2	9	0	0.957	1.000	1.000
589	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), HSD3B7(3), PLA2G12B(1), PLA2G3(2), PLA2G6(4), RDH11(2)	6660072	36	13	35	13	9	5	11	7	4	0	0.690	1.000	1.000
590	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST2(3), HS3ST3B1(1), XYLT1(5), XYLT2(7)	1926000	18	12	16	13	6	6	2	1	3	0	0.887	1.000	1.000
591	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), PIK3CA(6), PIK3R1(2), PLCG1(1), PTK2(3), PXN(1), RELA(3)	7861261	27	12	27	15	7	8	3	4	5	0	0.895	1.000	1.000
592	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(2), MAP3K1(3), NCOR2(5), RXRA(1), THRA(5), THRB(1)	4901856	21	12	18	10	6	5	5	2	3	0	0.814	1.000	1.000
593	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST2(3), HS3ST3B1(1), XYLT1(5), XYLT2(7)	1926000	18	12	16	13	6	6	2	1	3	0	0.887	1.000	1.000
594	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(3), PPP3CC(2), SYNJ1(2), SYNJ2(3), SYT1(1)	6244918	25	12	25	11	4	6	3	4	8	0	0.768	1.000	1.000
595	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(6), PGM1(1), PYGL(2), PYGM(2), TPI1(3)	3782512	17	11	17	11	7	4	1	1	4	0	0.844	1.000	1.000
596	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), LCT(6), NAGLU(2)	4109106	19	11	19	12	4	5	2	2	6	0	0.913	1.000	1.000
597	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(3), EP300(6), LPL(4), NCOA2(3), PPARG(1), RXRA(1)	5129266	18	11	18	10	6	2	4	2	4	0	0.894	1.000	1.000
598	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), PDE1B(2), PLCB1(1), PLCB2(5), PRL(4), TRH(3)	3137803	19	11	19	11	9	1	4	2	3	0	0.874	1.000	1.000
599	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(2), PLA2G6(4), PTGDS(2), PTGES(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1)	4265803	21	10	21	11	10	2	4	2	3	0	0.826	1.000	1.000
600	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(3), CD5(2), IL12B(1), ITGAX(3), TLR2(2), TLR4(1), TLR9(5)	5172921	22	9	22	10	9	5	2	5	1	0	0.655	1.000	1.000
601	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLD2(5), PPAP2B(2), PPAP2C(1)	6493807	31	9	29	16	11	4	6	4	6	0	0.904	1.000	1.000
602	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(1), JAK2(2), JAK3(3), PIAS1(2), PIAS3(2), PTPRU(6), REG1A(2), SOAT1(1)	3895037	20	9	19	15	9	2	5	0	4	0	0.989	1.000	1.000
603	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PIAS3(2), PTPRU(6), REG1A(2), SRC(2), STAT3(2)	4304090	23	9	22	16	9	5	5	0	4	0	0.970	1.000	1.000
604	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP23(2), SNAP29(3), STX11(2), STX12(1), STX2(1), STX3(1), STX4(2), STX7(1), TSNARE1(1), VAMP4(1), VAMP7(1), VTI1A(2)	4703952	18	8	18	13	8	0	2	2	6	0	0.991	1.000	1.000
605	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(1), JAK1(1), JAK2(2), JAK3(3), STAT1(3), STAT3(2), STAT5A(2), TYK2(2)	5208374	18	8	18	12	7	2	4	2	3	0	0.962	1.000	1.000
606	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1)	6291158	21	8	21	10	3	5	7	2	4	0	0.889	1.000	1.000
607	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(3), NR1I3(1), PTGS1(2), PTGS2(1)	1464698	11	7	10	5	8	1	0	2	0	0	0.749	1.000	1.000
608	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(1), JAK1(1), STAT1(3), STAT2(2), TYK2(2)	3025980	11	6	11	5	4	0	4	3	0	0	0.775	1.000	1.000
609	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), GGT1(1), MARS2(2), PAPSS1(2), PAPSS2(4), SCLY(2)	3464119	13	6	13	11	4	4	2	1	2	0	0.951	1.000	1.000
610	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	MTNR1A(1), MTNR1B(3), PTGDR(2), PTGFR(2), TBXA2R(1)	3240491	9	5	9	10	2	1	5	0	1	0	0.971	1.000	1.000
611	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL16(1), IL6(1), IL9(1)	2753138	4	2	4	3	0	2	1	1	0	0	0.838	1.000	1.000
612	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), TGM2(1)	1385991	2	2	2	2	2	0	0	0	0	0	0.893	1.000	1.000
613	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1)	1876503	2	1	2	4	1	1	0	0	0	0	0.984	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	470342	1	1	1	2	0	0	1	0	0	0	0.995	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		139470	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		420745	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
