rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(22), CDC25A(4), CDC25B(5), MYT1(2), RB1(3), TP53(59), WEE1(1)	13003593	96	82	81	5	24	16	11	19	24	2	2.77e-06	<1.00e-15	<2.05e-13
2	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	EIF2S1(1), NFKB1(3), RELA(3), TP53(59)	7150515	66	57	51	2	18	10	10	11	16	1	2.50e-06	<1.00e-15	<2.05e-13
3	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(5), ATM(22), BRCA1(1), CDKN1A(2), MDM2(1), NFKB1(3), RAD50(1), RAD51(1), RBBP8(1), RELA(3), TP53(59), TP73(2)	22068537	101	79	86	7	24	18	13	21	24	1	7.19e-06	1.33e-15	2.05e-13
4	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(22), ATR(3), TP53(59)	11869748	84	76	69	4	19	14	10	18	22	1	2.85e-05	1.33e-15	2.05e-13
5	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MYC(1), SP1(2), SP3(3), TP53(59), WT1(2)	5195066	68	61	53	2	17	8	9	14	19	1	6.36e-07	2.22e-15	2.74e-13
6	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNGR2(1), IKBKB(1), JAK2(1), NFKB1(3), RB1(3), RELA(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(59), USH1C(2), WT1(2)	13307491	78	63	63	4	21	13	11	12	19	2	1.20e-06	3.11e-15	3.03e-13
7	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CDKN1A(2), CDKN1B(6), CDKN2A(1), CFL1(1), E2F1(3), MDM2(1), TP53(59)	6200965	74	67	59	2	22	7	8	10	26	1	1.31e-06	3.44e-15	3.03e-13
8	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(2), ATM(22), CDKN1A(2), E2F1(3), MDM2(1), PCNA(2), RB1(3), TP53(59)	13404960	94	81	79	4	22	16	11	18	25	2	4.33e-07	4.11e-15	3.16e-13
9	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(5), CDKN2A(1), E2F1(3), MDM2(1), MYC(1), PIK3CA(16), PIK3R1(2), POLR1A(3), POLR1B(3), POLR1C(2), RAC1(1), RB1(3), TP53(59)	15014619	100	81	82	4	26	13	14	22	23	2	4.01e-08	5.11e-15	3.50e-13
10	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(8), AKT1(3), ATM(22), CDKN1A(2), CPB2(1), HIC1(4), HIF1A(2), IGFBP3(1), MDM2(1), NFKBIB(2), NQO1(2), TP53(59)	15329723	107	91	91	6	29	21	11	21	24	1	1.48e-07	6.33e-15	3.90e-13
11	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(8), DAXX(2), HRAS(4), PAX3(4), PML(1), RARA(1), RB1(3), SIRT1(3), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(59)	13992577	90	79	73	9	24	11	18	16	19	2	5.36e-05	7.55e-15	4.23e-13
12	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), EGFR(3), IGF1R(4), MYC(1), POLR2A(6), PPP2CA(2), PRKCA(2), RB1(3), TEP1(5), TNKS(5), TP53(59)	20709203	93	80	77	8	23	17	12	20	19	2	4.82e-06	4.59e-14	2.35e-12
13	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(2), ATM(22), CASP9(1), EIF2S1(1), PRKCA(2), PTK2(3), PXN(1), STAT1(1), TLN1(4), TP53(59)	20261367	99	85	83	10	22	18	11	23	24	1	0.000107	1.17e-13	5.57e-12
14	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(22), ATR(3), BRCA1(1), CDC25A(4), CDC25B(5), CDC34(1), CDKN1A(2), EP300(7), MDM2(1), MYT1(2), PRKDC(11), RPS6KA1(2), TP53(59), WEE1(1), YWHAQ(2)	30829426	123	96	108	10	34	21	13	25	29	1	1.67e-06	1.15e-12	5.04e-11
15	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(5), ATM(22), ATR(3), CCNA1(1), CDC25A(4), CDKN1A(2), CDKN1B(6), CDKN2A(1), DHFR(2), E2F1(3), GSK3B(1), HDAC1(1), RB1(3), TFDP1(2), TGFB2(2), TP53(59)	22361860	117	94	102	14	26	18	16	18	37	2	0.000290	9.60e-11	3.94e-09
16	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(1), EIF2S1(1), EIF4E(1), GSK3B(1), IGF1R(4), INPPL1(1), PDK2(1), PDPK1(1), PIK3CA(16), PIK3R1(2), PPP2CA(2), PTEN(17), RPS6(1)	14498505	52	46	48	4	6	9	7	15	15	0	0.00382	1.25e-07	4.83e-06
17	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(22), ATR(3), BRCA1(1), BRCA2(8), FANCA(2), FANCC(1), FANCD2(2), FANCF(1), FANCG(1), HUS1(1), RAD17(2), RAD50(1), RAD51(1), RAD9A(1), TP53(59)	32668046	106	91	91	11	22	17	11	26	29	1	0.000821	5.82e-07	2.11e-05
18	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(3), CDKN1B(6), GRB2(1), ILK(1), MAPK1(1), PDK2(1), PDPK1(1), PIK3CA(16), PIK3R1(2), PTEN(17), PTK2(3), SHC1(3), SOS1(4)	14192020	62	49	58	6	13	11	4	12	22	0	0.00500	1.54e-06	5.26e-05
19	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(2), GH1(3), GHR(1), HRAS(4), IGF1R(4), PIK3CA(16), PIK3R1(2), SHC1(3), SOD2(1), SOD3(1)	9840201	40	36	34	4	9	8	9	11	3	0	0.00533	6.22e-06	0.000202
20	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(2), ATM(22), ATR(3), BAI1(7), CASP8(1), CASP9(1), CCNB2(1), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN1A(2), CDKN2A(1), EI24(1), FAS(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(1), PERP(1), PPM1D(1), PTEN(17), RCHY1(2), RFWD2(1), RRM2(1), SERPINB5(4), SESN1(2), SESN2(4), SESN3(3), STEAP3(1), THBS1(3), TNFRSF10B(2), TP53(59), TP73(2), TSC2(7)	48055348	161	122	146	19	44	20	16	38	42	1	7.92e-06	2.49e-05	0.000766
21	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(1), EIF4B(2), EIF4E(1), EIF4G1(4), EIF4G2(1), EIF4G3(6), PDK2(1), PDPK1(1), PIK3CA(16), PIK3R1(2), PPP2CA(2), PTEN(17), RPS6(1), TSC1(2), TSC2(7)	20358835	67	52	63	5	14	9	5	20	19	0	0.000745	0.000148	0.00434
22	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(22), CDC25A(4), CDC25B(5), MYT1(2), WEE1(1)	10172870	34	28	34	3	7	9	2	9	7	0	0.0266	0.000366	0.0102
23	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(2), BIRC2(1), CASP8(1), CASP9(1), FAS(1), FASLG(1), MAP2K4(4), MAP3K1(5), MCL1(1), MDM2(1), MYC(1), NFKB1(3), PARP1(2), PRF1(2), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TP53(59), TRAF1(1), TRAF2(5)	27445890	98	75	83	14	26	19	10	22	20	1	0.000393	0.00241	0.0646
24	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), CASP9(1), GH1(3), GHR(1), NFKB1(3), PDPK1(1), PIK3CA(16), PIK3R1(2), PPP2CA(2), RELA(3)	10399193	35	27	31	3	6	12	4	11	2	0	0.00561	0.00342	0.0878
25	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(3)	1500904	7	6	7	0	3	1	1	2	0	0	0.146	0.00364	0.0896
26	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(3), COQ7(1), NDUFA12(1), NDUFA13(2)	2929137	9	8	9	1	2	3	3	0	1	0	0.120	0.0125	0.296
27	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(1), EIF4E(1), EIF4G1(4), EIF4G2(1), EIF4G3(6), GHR(1), IRS1(3), MAPK1(1), PDK2(1), PDPK1(1), PIK3CA(16), PIK3R1(2), PRKCA(2), PTEN(17)	20781608	60	50	56	8	11	8	4	19	18	0	0.0423	0.0157	0.359
28	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(1), AASS(3), KARS(2)	3479933	8	8	8	1	0	2	2	3	1	0	0.307	0.0228	0.496
29	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(1), EHHADH(5), SDS(1)	3557117	9	9	9	1	3	2	0	3	1	0	0.209	0.0233	0.496
30	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(2), AASDHPPT(1), AASS(3), KARS(2)	5143805	10	10	10	1	0	2	2	4	2	0	0.264	0.0262	0.533
31	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(1), EHHADH(5), HADH(3), HSD17B4(3), SIRT1(3), SIRT2(1), SIRT5(1), VNN2(1)	8706167	20	18	20	2	8	4	1	5	2	0	0.0423	0.0268	0.533
32	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), CREB1(1), GRB2(1), HRAS(4), MAPK1(1), MEF2A(1), MEF2C(3), MEF2D(1), NTRK1(9), PIK3CA(16), PIK3R1(2), PLCG1(1), RPS6KA1(2), SHC1(3)	13929443	48	36	42	7	20	11	8	7	2	0	0.00525	0.108	1.000
33	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(4), CDC25B(5), CDK7(2), CDKN1A(2), NEK1(3), WEE1(1)	5092069	17	13	17	2	8	2	0	2	5	0	0.193	0.110	1.000
34	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(1), SDHA(3), SDHB(2), SDHC(2), UQCRC1(2)	4880809	12	9	12	0	0	5	1	2	4	0	0.0186	0.116	1.000
35	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), ATF3(1), CYR61(1), DUSP14(1), EIF4E(1), IFRD1(1), IL1A(1), JUND(2), NR4A3(5), WDR1(1)	7921832	17	12	17	1	2	6	4	4	1	0	0.0187	0.122	1.000
36	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(2), HDC(2), PNMT(1), TPH1(1)	4435557	11	11	11	2	6	1	2	2	0	0	0.182	0.159	1.000
37	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CDKN1A(2), CDKN1B(6), E2F1(3), HRAS(4), MAPK1(1), NFKB1(3), PAK1(1), PIK3CA(16), PIK3R1(2), RAC1(1), RAF1(1), RB1(3), RELA(3), TFDP1(2)	14901154	51	39	45	8	11	9	11	8	11	1	0.0294	0.161	1.000
38	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(2), BCL2L11(1), BIRC2(1), BIRC5(2), CASP1(2), CASP10(1), CASP8(1), CASP9(1), DFFA(4), FAS(1), FASLG(1), HELLS(1), IKBKB(1), IRF2(1), IRF3(1), IRF4(4), IRF5(1), IRF6(3), MAP2K4(4), MAP3K1(5), MDM2(1), MYC(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PRF1(2), RELA(3), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(7), TP53(59), TP73(2), TRAF1(1), TRAF2(5)	42114445	131	94	116	19	36	22	12	33	27	1	0.000127	0.170	1.000
39	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), GRB2(1), HRAS(4), KLK2(1), NTRK1(9), PIK3CA(16), PIK3R1(2), PLCG1(1), PRKCA(2), SHC1(3), SOS1(4)	11509917	46	34	40	8	17	10	6	8	5	0	0.0285	0.180	1.000
40	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADH(3), HADHB(1), HSD17B4(3), MECR(1), PPT2(2)	6224096	12	12	12	2	6	3	0	1	2	0	0.150	0.184	1.000
41	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(6), CUL1(2), E2F1(3), RB1(3), TFDP1(2)	6326607	16	12	16	3	4	0	2	0	9	1	0.426	0.187	1.000
42	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IL12A(1), IL12B(1)	2214277	4	4	4	1	1	0	0	2	1	0	0.623	0.199	1.000
43	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(1), NR1I3(2), PTGS1(2), PTGS2(5)	3960371	11	9	11	2	4	3	0	2	2	0	0.227	0.222	1.000
44	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(2), LARS(3), LARS2(2), PDHA1(1), PDHA2(4)	7394774	13	11	12	0	1	4	1	5	2	0	0.0215	0.227	1.000
45	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), GRB2(1), HRAS(4), IGF1R(4), IRS1(3), MAPK1(1), PIK3CA(16), PIK3R1(2), RAF1(1), SHC1(3), SOS1(4)	14049195	42	34	36	8	12	7	9	10	4	0	0.0621	0.238	1.000
46	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(2), GOT2(1), LDHB(1), LDHC(1), MPST(1)	5063710	12	8	12	0	5	3	2	1	1	0	0.0175	0.250	1.000
47	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(10), AXIN1(1), CD14(2), CTNNB1(13), DVL1(1), FZD1(2), GJA1(1), GNAI1(2), GSK3B(1), IRAK1(1), LEF1(2), LY96(1), NFKB1(3), PDPK1(1), PIK3CA(16), PIK3R1(2), PPP2CA(2), RELA(3), TIRAP(1), TLR4(2), WNT1(1)	22608607	71	55	64	11	15	17	9	18	12	0	0.00178	0.256	1.000
48	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(4), CDC25B(5), CDK7(2), SHH(2)	6419181	14	12	14	2	6	1	2	2	3	0	0.165	0.258	1.000
49	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(3), SEC61A2(1), SRP19(1), SRP54(2)	5589755	7	7	6	0	0	2	1	2	2	0	0.151	0.276	1.000
50	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR3(1), PAK1(1), PDGFRA(3), PIK3CA(16), PIK3R1(2), RAC1(1)	9923578	24	21	21	4	6	5	4	7	2	0	0.173	0.281	1.000
51	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(1), ENO3(1), FARS2(2), GOT1(2), GOT2(1), PAH(1), YARS(3)	6124126	14	9	14	1	7	4	1	1	1	0	0.0298	0.288	1.000
52	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR2(4), MTMR6(1), NFS1(1), THTPA(3)	4716616	10	9	10	2	3	1	3	1	2	0	0.283	0.324	1.000
53	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	377474	1	1	1	0	0	0	0	0	1	0	0.607	0.325	1.000
54	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), CD4(1), HLA-DRA(1), IL4(1), IL6(1)	3947339	6	6	6	1	3	1	0	1	1	0	0.398	0.333	1.000
55	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(3), DLD(2), DUSP8(3), GAB1(1), GCK(4), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K11(1), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K9(4), NFATC3(1), PAPPA(3), SHC1(3), TP53(59), TRAF6(2)	37090249	120	87	104	17	37	22	11	20	29	1	7.06e-05	0.336	1.000
56	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(1), AKT3(1), BPNT1(2), GRB2(1), ILK(1), MAPK1(1), PDK1(2), PIK3CA(16), PIK3CD(5), PTEN(17), RBL2(2), SHC1(3), SOS1(4)	15042558	59	50	55	11	15	8	6	13	17	0	0.0881	0.349	1.000
57	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(4)	2881639	6	5	5	1	2	0	1	2	1	0	0.480	0.359	1.000
58	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(1)	1135539	2	2	2	0	0	2	0	0	0	0	0.516	0.360	1.000
59	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(3)	1332809	4	4	4	2	0	1	0	2	1	0	0.808	0.364	1.000
60	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(5), GCDH(1), SDHB(2), SDS(1)	5756404	13	10	13	2	5	4	0	3	1	0	0.149	0.366	1.000
61	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1)	4184643	7	6	7	1	2	1	1	2	1	0	0.243	0.369	1.000
62	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(5), HADHB(1), SDS(1)	6177211	14	13	14	3	5	2	1	4	2	0	0.321	0.373	1.000
63	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), HLA-DRA(1)	2240263	3	3	3	0	2	0	0	0	1	0	0.472	0.388	1.000
64	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(3), RB1(3), SP1(2), SP3(3)	4947836	12	11	12	3	2	2	1	2	4	1	0.498	0.393	1.000
65	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	843933	1	1	1	1	0	1	0	0	0	0	0.872	0.413	1.000
66	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP5(1), ACPP(1), ACPT(3), ENPP1(3), ENPP3(2), RFK(1), TYR(2)	7172277	14	14	13	3	3	3	1	3	4	0	0.326	0.419	1.000
67	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(1)	1555761	4	3	4	0	1	0	0	1	2	0	0.365	0.422	1.000
68	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(10), AXIN1(1), BTRC(3), CTNNB1(13), DLL1(3), DVL1(1), FZD1(2), GSK3B(1), NOTCH1(6), WNT1(1)	15751269	41	31	38	7	10	5	5	8	12	1	0.0204	0.434	1.000
69	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(2), PDE6D(1)	2860952	5	4	5	1	2	2	0	0	1	0	0.430	0.438	1.000
70	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), GPHN(2), UBQLN1(2)	8799202	13	11	13	0	2	3	1	5	2	0	0.0157	0.449	1.000
71	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(1)	1657943	2	2	2	0	0	0	0	0	2	0	0.475	0.465	1.000
72	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(1)	1922079	3	3	3	0	1	1	0	1	0	0	0.367	0.471	1.000
73	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS2(1), SULT1E1(2), SUOX(1)	4518184	6	6	6	0	3	1	0	1	1	0	0.208	0.486	1.000
74	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(2), ACAT1(2), ECHS1(1)	3997511	5	5	4	1	4	0	0	1	0	0	0.409	0.499	1.000
75	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(4), SNCAIP(3), UBE2F(1), UBE2L3(1)	4754453	11	8	11	2	3	2	1	5	0	0	0.258	0.505	1.000
76	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), UGDH(2), UGP2(1)	3623055	4	4	4	1	1	0	1	2	0	0	0.630	0.511	1.000
77	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD28(2), CD3D(1), CD4(1)	2377872	6	3	6	1	0	2	1	2	1	0	0.352	0.516	1.000
78	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNE2(1), CDKN1B(6), CDKN2A(1), E2F1(3)	6591781	12	11	12	2	2	1	0	1	8	0	0.532	0.518	1.000
79	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), UGDH(2)	2842939	3	3	3	1	1	0	1	1	0	0	0.708	0.551	1.000
80	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(16), PIK3R1(2), PLCB1(3), PLCG1(1), PRKCA(2), VAV1(3)	9494996	30	26	26	6	8	7	3	11	1	0	0.190	0.563	1.000
81	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(1), HMGCL(1), OXCT1(5)	2509642	9	5	9	2	2	2	2	3	0	0	0.415	0.566	1.000
82	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2), HSD3B2(2)	6759170	13	10	13	2	3	3	1	3	3	0	0.150	0.570	1.000
83	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2), HSD3B2(2)	6759170	13	10	13	2	3	3	1	3	3	0	0.150	0.570	1.000
84	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(1), HLA-DRA(1)	1746358	4	2	4	0	1	0	1	1	1	0	0.355	0.585	1.000
85	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(3), HSD17B2(1), HSD17B3(1), HSD17B4(3), HSD17B7(2), HSD3B1(2), HSD3B2(2)	5979653	15	12	14	5	2	4	2	3	3	1	0.530	0.604	1.000
86	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(3), AOC3(1), CES1(3)	4423346	7	5	7	1	1	2	0	4	0	0	0.347	0.614	1.000
87	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(2), CTH(2), GOT1(2), GOT2(1), LDHAL6A(1), LDHB(1), LDHC(1), MPST(1), SDS(1), SULT4A1(1)	9256352	17	12	17	2	7	4	2	2	2	0	0.0614	0.614	1.000
88	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(4), NRG2(4), NRG3(3), PRKCA(2)	6653203	13	12	13	4	5	2	2	2	2	0	0.448	0.614	1.000
89	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(4), MMP14(1), MMP9(5)	5517903	10	9	8	3	4	0	4	2	0	0	0.427	0.633	1.000
90	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), PRKCE(2)	5835478	9	7	9	0	2	1	2	3	1	0	0.0506	0.633	1.000
91	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(1), PPARG(1), RXRA(2), TNF(1)	4289930	6	5	6	1	2	0	2	1	1	0	0.367	0.637	1.000
92	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1A(2), BMPR1B(2), BMPR2(3)	4610072	9	6	9	2	1	1	1	4	2	0	0.628	0.638	1.000
93	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(1), FH(3), IDH1(6), MDH1(1), SDHB(2), SUCLA2(1)	6580929	15	11	12	3	4	3	3	4	1	0	0.168	0.639	1.000
94	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), CASP9(1), HRAS(4), NFKB1(3), PIK3CA(16), PIK3R1(2), RAC1(1), RAF1(1), RALBP1(1), RALGDS(2), RELA(3), RHOA(2)	13938297	39	32	32	8	6	10	9	12	2	0	0.0786	0.642	1.000
95	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), FMOD(1), KERA(2)	2654832	5	5	5	2	1	0	0	3	1	0	0.869	0.670	1.000
96	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), CREB1(1), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAPK1(1), NFKB1(3), PIK3CA(16), PIK3R1(2), RB1(3), RELA(3), SP1(2)	14313229	41	30	37	7	9	13	5	8	5	1	0.0369	0.680	1.000
97	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(1), STX1A(1)	2402720	3	3	3	1	2	1	0	0	0	0	0.585	0.687	1.000
98	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS7(1), DHRSX(5), PON1(1), PON2(3), PON3(1), RDH12(1)	6628567	13	8	13	1	7	0	2	3	1	0	0.0564	0.690	1.000
99	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), CBS(1), CTH(2), MARS2(1), MAT1A(3), PAPSS2(1), SEPHS1(1)	9104189	11	9	11	1	3	3	1	1	3	0	0.114	0.706	1.000
100	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2), ITPKB(2)	4444274	5	5	5	1	2	1	0	2	0	0	0.427	0.709	1.000
101	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(1), IL6(1), LDLR(3), LPL(1)	3937715	8	7	8	3	3	2	0	2	1	0	0.490	0.732	1.000
102	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	1214627	2	1	2	1	0	1	1	0	0	0	0.755	0.757	1.000
103	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT1(1), FUT2(1), FUT3(2), ST3GAL3(1)	5333690	11	9	11	3	2	2	2	5	0	0	0.494	0.770	1.000
104	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), FADS2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	7439179	13	9	13	2	2	1	1	4	5	0	0.242	0.813	1.000
105	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST3A1(1), XYLT1(6), XYLT2(1)	4737589	10	10	10	3	4	3	0	1	2	0	0.306	0.815	1.000
106	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST3A1(1), XYLT1(6), XYLT2(1)	4737589	10	10	10	3	4	3	0	1	2	0	0.306	0.815	1.000
107	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), GNGT1(1), HTR2C(3), PLCB1(3), TUB(2)	5294439	10	9	10	3	4	2	1	3	0	0	0.485	0.823	1.000
108	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(1), CUL1(2), E2F1(3), RB1(3), TFDP1(2)	6100856	11	7	11	3	4	0	2	0	4	1	0.426	0.825	1.000
109	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(3), EIF2B5(1), EIF2S1(1), EIF5(2), GSK3B(1), PPP1CA(1)	8541990	13	12	13	3	4	0	3	4	2	0	0.328	0.826	1.000
110	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND3(1), CCNH(1), CDC25A(4), CDK7(2), CDKN1A(2), CDKN1B(6), CDKN2A(1), E2F1(3), RB1(3), RBL1(2), TFDP1(2)	11871482	28	19	28	8	7	3	3	2	12	1	0.478	0.826	1.000
111	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(2), AKT1(3), ASAH1(1), GNAI1(2), GNB1(1), GNGT1(1), ITGAV(3), MAPK1(1), PDGFA(2), PDGFRA(3), PIK3CA(16), PIK3R1(2), PLCB1(3), PRKCA(2), PTK2(3), RAC1(1), SMPD2(2), SPHK1(1)	20256385	49	37	45	9	15	12	5	14	3	0	0.0279	0.828	1.000
112	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), CD8A(1), CSF1(1), IL4(1), IL6(1), IL7(2), IL9(2)	4406485	9	7	9	3	1	1	1	2	4	0	0.672	0.830	1.000
113	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP5(1), ACPP(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), PON1(1)	21608147	46	37	45	8	18	5	6	10	7	0	0.0405	0.835	1.000
114	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(1), ABCG2(3), BCHE(3), CES1(3), CES2(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2)	16898592	21	14	21	0	7	2	1	7	4	0	0.00214	0.838	1.000
115	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(2), GOT1(2), GOT2(1), PAH(1), YARS(3), YARS2(3)	6409898	14	10	14	3	7	4	1	1	1	0	0.172	0.841	1.000
116	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(1), HLA-DRA(1), IL10(1), IL4(1)	2928620	6	4	6	2	3	0	1	1	1	0	0.569	0.842	1.000
117	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(8)	6226633	8	5	8	1	0	2	1	1	4	0	0.454	0.843	1.000
118	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CDC34(1), CUL1(2), E2F1(3), RB1(3), TFDP1(2)	6296235	12	8	12	4	4	1	2	0	4	1	0.498	0.847	1.000
119	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(1), GLUD1(2)	4074013	5	3	5	0	3	0	0	1	1	0	0.249	0.853	1.000
120	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), CTH(2), MUT(3)	3618920	6	5	6	4	1	1	0	2	2	0	0.961	0.854	1.000
121	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP5(1), ACPP(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CMBL(1), CYP3A43(1), CYP3A7(1), DHRS1(1), DHRS7(1), DHRSX(5), PON1(1), PON2(3), PON3(1)	13295315	26	19	25	5	9	3	3	6	5	0	0.0938	0.856	1.000
122	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(3), PLCB1(3), PRKCA(2), RELA(3)	6059591	11	8	11	2	3	4	1	3	0	0	0.197	0.861	1.000
123	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3), NR1H3(1), RXRA(2)	4022180	8	5	8	4	4	3	1	0	0	0	0.601	0.863	1.000
124	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	2327123	1	1	1	1	1	0	0	0	0	0	0.887	0.872	1.000
125	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(2)	5088783	9	6	9	2	1	2	1	2	3	0	0.345	0.886	1.000
126	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(2), CD3D(1), CD86(1), GRB2(1), HLA-DRA(1), ITK(3), PIK3CA(16), PIK3R1(2), PTPN11(1)	9485222	28	20	25	6	10	6	4	6	2	0	0.185	0.891	1.000
127	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(4), EPRS(4), FARS2(2), GARS(1), HARS(1), IARS(2), KARS(2), LARS(3), LARS2(2), MARS2(1), QARS(1), SARS(2), TARS(3), WARS(1), WARS2(2), YARS(3)	23701989	35	25	35	4	13	7	5	8	2	0	0.0115	0.896	1.000
128	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMD14(1), RPN1(1), RPN2(2), UBE3A(1)	9519258	15	8	15	1	3	3	2	3	4	0	0.0401	0.897	1.000
129	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD1(2), GLUD2(2)	3361215	4	4	4	2	2	1	0	1	0	0	0.784	0.898	1.000
130	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(1), CD3D(1), CD4(1), CD8A(1), IL6(1)	4570972	6	6	6	3	1	2	0	2	1	0	0.691	0.899	1.000
131	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1), SHMT2(1)	3053315	2	2	2	0	1	0	0	0	1	0	0.393	0.900	1.000
132	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(5), DHFR(2), GART(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1), MTHFR(2), MTR(1), SHMT1(1), SHMT2(1), TYMS(1)	13239086	25	20	25	5	5	5	3	6	6	0	0.176	0.907	1.000
133	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(4), HMGB2(2), TOP2A(4), TOP2B(2)	6564891	12	9	12	4	3	3	1	2	3	0	0.763	0.907	1.000
134	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY2(4), CSNK1E(3), PER1(4)	6230589	12	7	12	2	4	4	1	3	0	0	0.214	0.910	1.000
135	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(1), JAK1(6), JAK2(1), STAT1(1)	6092911	9	7	9	3	0	3	1	2	3	0	0.671	0.910	1.000
136	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK12(1), MAPK13(1), MAPK8IP3(4), MAPKAPK5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PIK3CA(16), PIK3CD(5), PIK3R1(2), SYT1(1), TRAF2(5), TRAF5(1), TRAF6(2)	24700433	56	38	53	9	20	9	3	14	10	0	0.00786	0.914	1.000
137	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1)	6464824	10	5	10	0	0	1	2	3	4	0	0.0544	0.922	1.000
138	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), ARSB(2), ARSD(1), ARSE(2), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD3B1(2), HSD3B2(2), STS(1), SULT1E1(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1)	20092640	32	26	32	5	7	6	2	11	6	0	0.0487	0.924	1.000
139	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(5), DHFR(2), GART(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1), MTHFR(2), MTR(1), SHMT1(1), SHMT2(1), TYMS(1)	13984942	25	20	25	5	5	5	3	6	6	0	0.178	0.935	1.000
140	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL16(5), IL1A(1), IL4(1), IL6(1), IL9(2), TNF(1)	7357338	15	13	15	5	5	3	1	3	3	0	0.425	0.938	1.000
141	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(1), HRAS(4), SHC1(3), SOS1(4)	6472275	13	11	11	4	7	1	3	0	2	0	0.390	0.939	1.000
142	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(3), CHST12(1), CHST13(1), PAPSS2(1), SULT1A1(1), SULT1E1(2), SUOX(1)	6801496	12	11	12	4	7	1	1	1	2	0	0.495	0.946	1.000
143	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(2), AKT1(3), CSF2RB(1), IGF1R(4), IL3RA(3), KIT(3), PIK3CA(16), PIK3R1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	16195322	41	28	37	8	10	8	7	13	3	0	0.0518	0.946	1.000
144	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(1), GAD1(2), GAD2(9)	4229060	12	11	12	7	6	1	1	2	2	0	0.830	0.946	1.000
145	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR3(1), RAC1(1), WASF1(2)	6004781	5	5	5	2	1	1	1	2	0	0	0.738	0.948	1.000
146	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(3), ALAS2(1), CPOX(1), HMBS(1)	5476540	6	5	6	2	2	1	0	2	1	0	0.633	0.949	1.000
147	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BCL2L11(1), CASP9(1), CES1(3)	7875441	7	5	7	1	0	1	0	6	0	0	0.494	0.949	1.000
148	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(3), DPYS(2), ENPP1(3), ENPP3(2), PANK1(3), PANK2(3), PANK3(1), PPCS(1)	10284280	19	17	18	5	4	5	3	3	4	0	0.384	0.949	1.000
149	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	DCXR(2), UGDH(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1)	12998242	16	13	16	3	3	4	1	6	2	0	0.235	0.950	1.000
150	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(2), ACADVL(1), ACSL1(3), CPT1A(1), CPT2(2), EHHADH(5), PECR(1), SCP2(3), SLC25A20(1)	12426847	19	15	18	4	8	3	1	2	5	0	0.217	0.958	1.000
151	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(5)	5310767	11	7	11	3	3	2	2	4	0	0	0.492	0.959	1.000
152	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(2)	2274600	3	2	3	2	1	2	0	0	0	0	0.769	0.959	1.000
153	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(3), EXTL1(3), EXTL3(4), GLCE(1), HS2ST1(1), HS3ST3A1(1), HS6ST1(3), HS6ST2(1), NDST1(3), NDST2(5), NDST3(3), NDST4(6)	15152444	37	30	37	9	10	8	7	7	5	0	0.119	0.960	1.000
154	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(2), CBS(1), CTH(2), DNMT1(3), DNMT3A(2), DNMT3B(6), MARS2(1), MAT1A(3), MTR(1)	12787066	23	17	23	5	9	4	2	2	6	0	0.114	0.960	1.000
155	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMD1(2), PSMD11(1), PSMD2(1), PSMD6(1)	11847507	16	9	16	1	3	2	2	5	4	0	0.0481	0.961	1.000
156	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP5(1), ACPP(1), ACPT(3), ENPP1(3), ENPP3(2), LHPP(1), MTMR2(4), MTMR6(1), RFK(1), TYR(2)	11112397	20	18	19	5	4	4	3	4	5	0	0.299	0.961	1.000
157	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(6), STAT1(1), STAT2(2), TYK2(2)	7997376	12	9	12	5	1	3	1	3	4	0	0.735	0.962	1.000
158	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(3), JAK1(6), JAK2(1), TYK2(2)	7753804	13	10	13	4	1	3	2	3	4	0	0.496	0.962	1.000
159	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(3), JAK1(6), JAK2(1), TYK2(2)	7753804	13	10	13	4	1	3	2	3	4	0	0.496	0.962	1.000
160	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(2), ALOX5(1), DPEP1(2), LTC4S(1), PLA2G2A(1), PLA2G6(2), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2)	11011159	21	14	21	4	9	4	0	5	3	0	0.0741	0.963	1.000
161	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(1), KLRC1(1), PAK1(1), PIK3CA(16), PIK3R1(2), RAC1(1), SYK(2), VAV1(3)	13729050	28	25	25	7	8	4	5	8	3	0	0.407	0.964	1.000
162	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BRAF(8), CREB1(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(1)	8167713	16	16	15	5	2	1	3	6	4	0	0.725	0.966	1.000
163	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2), PDXK(1), PSAT1(1)	3590408	4	3	4	3	0	2	0	1	1	0	0.895	0.968	1.000
164	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOC(3)	2883535	5	3	5	2	0	2	2	1	0	0	0.649	0.968	1.000
165	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), HMOX1(2), IL10(1), IL10RA(2), IL1A(1), IL6(1), JAK1(6), STAT1(1), STAT3(6), TNF(1)	8989834	22	17	22	8	6	4	3	5	4	0	0.468	0.969	1.000
166	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(2), EPX(4), LPO(2), MPO(3), PRDX1(1), SHMT1(1), SHMT2(1), TPO(5)	8682929	19	15	19	5	9	2	1	5	2	0	0.270	0.971	1.000
167	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), KEAP1(4), MAFF(1), MAPK1(1), NFE2L2(1), PRKCA(2)	6501032	10	8	10	3	4	2	2	2	0	0	0.376	0.971	1.000
168	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD2(1), CD3D(1), CD4(1), IL12A(1), IL12B(1), IL12RB2(1), JAK2(1), STAT4(6), TYK2(2)	10735192	17	13	17	5	1	4	2	6	4	0	0.436	0.971	1.000
169	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(4), CDC25B(5), GRB2(1), PRKCA(2), PTPRA(5)	6781748	17	12	17	5	8	3	1	3	2	0	0.377	0.971	1.000
170	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB3A(1)	3132633	3	3	3	4	1	0	0	1	1	0	0.975	0.971	1.000
171	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), NAT2(1), XDH(1)	5907141	11	8	11	4	6	1	1	2	1	0	0.603	0.973	1.000
172	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	GRB2(1), HRAS(4), IGF1R(4), IRS1(3), PIK3CA(16), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(1), SHC1(3), SOS1(4)	18220269	40	30	35	9	13	5	9	9	4	0	0.123	0.974	1.000
173	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	IDI2(2), SQLE(1)	3129059	3	2	3	2	1	0	1	0	1	0	0.791	0.975	1.000
174	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(1), JAK3(1), MAPK1(1), STAT3(6), TYK2(2)	8612725	17	14	17	9	2	4	2	5	4	0	0.881	0.977	1.000
175	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(3), RELA(3), TNFRSF13B(3), TRAF2(5), TRAF5(1), TRAF6(2)	10668296	17	9	17	3	6	4	1	4	2	0	0.111	0.977	1.000
176	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(2), BCAR1(3), CTNNA1(2), CTNNA2(5), CTNNB1(13), PTK2(3), PXN(1), VCL(1)	14056725	31	24	28	7	8	4	4	10	5	0	0.195	0.978	1.000
177	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC1(3), APOBEC2(1), APOBEC3B(4), APOBEC3G(1)	5431405	12	10	12	5	5	1	2	2	2	0	0.761	0.979	1.000
178	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT5(1), FUT8(2), ST3GAL1(2), ST3GAL3(1)	5778649	12	9	12	4	6	2	0	4	0	0	0.603	0.979	1.000
179	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ECHS1(1), EHHADH(5), SDS(1)	8937545	19	16	18	6	6	3	3	4	3	0	0.457	0.980	1.000
180	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(1), CYP1A2(1), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2J2(1), CYP3A43(1), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), RDH12(1)	17628767	31	21	31	6	10	2	3	10	6	0	0.155	0.980	1.000
181	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(22), BMPR1B(2), CDKN1B(6), CEBPB(1), EGR1(3), FSHR(2), GJA4(2), INHA(1), LHCGR(1), MLH1(2), MSH5(1), NCOR1(8), NRIP1(4), PGR(2), PRLR(1), PTGER2(2), VDR(2), ZP2(3)	25902331	65	50	65	14	10	13	6	11	25	0	0.195	0.980	1.000
182	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(10), AXIN1(1), BTRC(3), CREBBP(8), CTNNB1(13), DVL1(1), FZD1(2), GSK3B(1), HDAC1(1), MAP3K7(2), MYC(1), NLK(1), PPARD(4), PPP2CA(2), TLE1(4), WIF1(2), WNT1(1)	21648221	57	44	54	12	12	9	8	12	16	0	0.0612	0.981	1.000
183	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(2), UBE2C(1), UBE2I(1), UBE2L3(1), UBE2S(1), UBE3A(1)	7766740	8	7	8	3	2	1	2	2	1	0	0.606	0.982	1.000
184	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(4), PCYT1A(1), PDHA1(1), PDHA2(4), SLC18A3(1)	5098348	12	9	11	6	4	4	0	1	3	0	0.537	0.983	1.000
185	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ENO1(3), HK1(2), PFKL(2), PKLR(1)	6798617	8	5	8	4	5	0	0	0	3	0	0.704	0.983	1.000
186	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS7(1), DHRSX(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1)	12248012	15	11	15	3	6	0	2	3	4	0	0.265	0.984	1.000
187	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), CHRNG(1), MUSK(3), PIK3CA(16), PIK3R1(2), PTK2(3)	11945114	28	22	24	8	8	8	3	8	1	0	0.263	0.984	1.000
188	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH12(1)	3513530	1	1	1	1	1	0	0	0	0	0	0.894	0.985	1.000
189	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	FLT3(2), IL1A(1), IL6(1), IL9(2), TGFB2(2)	6008566	8	8	8	9	1	1	3	1	2	0	0.994	0.986	1.000
190	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), SHMT1(1), SHMT2(1)	4009978	3	3	3	2	1	1	0	0	1	0	0.739	0.986	1.000
191	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(2), EPX(4), LPO(2), MPO(3), MTHFR(2), SHMT1(1), SHMT2(1), TPO(5)	8551912	20	16	20	5	10	3	1	4	2	0	0.214	0.987	1.000
192	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(3), ERBB3(5), NRG1(4)	7598482	15	13	15	5	2	2	0	9	2	0	0.648	0.987	1.000
193	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(8), ZAP70(6)	6687301	18	15	18	7	7	4	2	5	0	0	0.493	0.987	1.000
194	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(3), ALAS2(1), HMBS(1)	5588764	5	4	5	2	2	1	0	1	1	0	0.715	0.988	1.000
195	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(2), ARHGEF1(5), F2(2), F2R(2), GNA13(2), GNAI1(2), GNB1(1), GNGT1(1), MAP3K7(2), PIK3CA(16), PIK3R1(2), PLCB1(3), PPP1R12B(1), PRKCA(2), ROCK1(5)	19013868	48	39	44	11	14	8	7	15	4	0	0.148	0.988	1.000
196	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(1)	4146376	8	8	8	7	4	2	0	1	1	0	0.947	0.989	1.000
197	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(2), ALPPL2(2), DHFR(2), FPGS(1), SPR(1)	4783176	9	8	9	6	3	3	0	1	2	0	0.851	0.989	1.000
198	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FYN(1), THBS1(3)	5462957	5	4	5	2	2	1	1	1	0	0	0.628	0.989	1.000
199	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXB(2), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2)	14998628	28	20	28	9	14	3	1	4	6	0	0.348	0.989	1.000
200	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(6), PTPRU(4), REG1A(1), STAT1(1), STAT2(2), TYK2(2)	9219819	17	12	17	7	4	4	1	4	4	0	0.668	0.990	1.000
201	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(1), PRKCA(2), TGM2(1)	3607014	6	5	6	4	3	1	0	1	1	0	0.814	0.990	1.000
202	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	11096494	17	13	17	4	3	3	2	5	4	0	0.367	0.990	1.000
203	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	11096494	17	13	17	4	3	3	2	5	4	0	0.367	0.990	1.000
204	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	11096494	17	13	17	4	3	3	2	5	4	0	0.367	0.990	1.000
205	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), BHMT(2), CBS(1), CTH(2), DNMT1(3), DNMT3A(2), DNMT3B(6), MARS2(1), MAT1A(3), MTAP(1), MTR(1), SRM(1)	15213906	26	18	26	7	11	4	2	3	6	0	0.178	0.990	1.000
206	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(2), CASP9(1), DAXX(2), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1), TNF(1)	8362558	11	10	11	6	2	1	1	4	3	0	0.945	0.990	1.000
207	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(1), CS(3), HAO1(2), MDH1(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1)	9460948	15	11	15	4	2	2	5	3	3	0	0.347	0.991	1.000
208	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(1), GPR171(1), GPR18(2), GPR39(3), GPR45(2), GPR68(2), GPR75(2)	7250189	15	8	15	4	5	2	0	7	1	0	0.374	0.991	1.000
209	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(1), FUT2(1), ST8SIA1(1)	4515877	4	4	4	5	0	3	0	0	1	0	0.972	0.991	1.000
210	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(3), MDH1(1), ME1(3), PC(2), PDHA1(1)	6802237	12	7	12	3	1	3	2	2	4	0	0.309	0.991	1.000
211	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1(3), CAMK1G(2), CAMK2A(1), CAMK2D(2), CAMK4(4), CAMKK1(2), CREB1(1), SYT1(1)	8491574	17	11	17	6	7	2	0	6	2	0	0.559	0.992	1.000
212	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), MAP2K3(1), NFATC1(2), NFATC2(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	8913820	13	10	13	5	4	2	2	5	0	0	0.521	0.992	1.000
213	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXB(2), LCT(6), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2)	12164815	23	18	23	8	10	3	1	3	6	0	0.488	0.992	1.000
214	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1)	5873133	12	10	11	5	3	1	3	3	2	0	0.736	0.992	1.000
215	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1)	5873133	12	10	11	5	3	1	3	3	2	0	0.736	0.992	1.000
216	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(3), FH(3), MDH1(1), SDHA(3), SUCLA2(1)	6939714	12	7	12	3	0	2	3	4	3	0	0.329	0.993	1.000
217	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP3(2), ARFGEF2(2), CLTB(1), COPA(2), GBF1(6), GPLD1(3), KDELR1(1), KDELR3(1)	12001371	19	14	19	5	7	4	2	2	4	0	0.223	0.993	1.000
218	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(8), DFFA(4), GZMA(1), HMGB2(2), NME1(1), PRF1(2)	7814343	18	14	18	9	4	5	2	4	3	0	0.831	0.994	1.000
219	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(1), CS(3), HAO1(2), MDH1(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1)	9904861	15	11	15	4	2	2	5	3	3	0	0.345	0.994	1.000
220	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CYP2C19(4), CYP2C9(3), DHRS1(1), DHRS7(1), DHRSX(5), ECHS1(1), EHHADH(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1)	22799486	36	28	36	7	13	3	5	9	6	0	0.0891	0.994	1.000
221	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(2), HDAC9(2), MEF2A(1), MEF2C(3), MEF2D(1)	5592666	12	10	12	5	5	2	1	4	0	0	0.642	0.994	1.000
222	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1R(3), TNF(1)	4825463	5	5	5	3	3	0	0	0	2	0	0.861	0.995	1.000
223	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), DPYD(3), DPYS(2), ENPP1(3), ENPP3(2), ILVBL(3), PANK1(3), PANK2(3), PANK3(1), PPCS(1)	12774758	23	19	22	7	5	5	3	4	6	0	0.477	0.995	1.000
224	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(2), IARS2(1), ILVBL(3), LARS(3), LARS2(2), PDHA1(1), PDHA2(4), VARS(4), VARS2(4)	13665443	26	18	25	5	5	5	1	10	5	0	0.184	0.995	1.000
225	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(2), GOT2(1), TYR(2)	3455567	5	5	5	3	3	1	0	1	0	0	0.812	0.995	1.000
226	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(3), CALM1(1), GNAS(2), GNB1(1), GNGT1(1), NFKB1(3), NOS3(2), NPPA(1), PIK3CA(16), PIK3R1(2), RELA(3), SYT1(1)	13105381	36	28	32	9	7	11	4	12	2	0	0.295	0.996	1.000
227	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(1), FUT2(1), GBGT1(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1)	7433064	12	11	12	8	5	5	0	0	2	0	0.869	0.996	1.000
228	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	DCXR(2), UGDH(2), UGP2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3), XYLB(1)	20209130	34	25	34	7	5	5	4	15	5	0	0.168	0.996	1.000
229	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(2), BIK(1), BIRC2(1), CASP8(1), CASP9(1), DFFA(4)	9942795	10	6	10	2	1	5	0	3	1	0	0.347	0.996	1.000
230	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(4), GLUD1(2), GOT1(2)	5754870	9	7	9	5	4	1	0	3	1	0	0.854	0.996	1.000
231	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(1), CASP8(1), CFLAR(2), DAXX(2), DFFA(4), FAF1(4), LMNA(4), LMNB2(2), MAP2K4(4), MAP3K1(5), MAP3K7(2), PAK1(1), PAK2(2), PRKDC(11), PTPN13(1), RB1(3), RIPK2(2), SPTAN1(2)	29878586	54	34	54	8	18	12	5	9	9	1	0.0101	0.996	1.000
232	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(1), HLA-A(1), ICAM1(1), ITGAL(5), ITGB2(2), PRF1(2)	6429255	13	12	12	9	7	1	0	3	2	0	0.882	0.996	1.000
233	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(8), EP300(7), ESR1(2), MAPK1(1), PELP1(2)	10811985	20	16	20	6	8	3	2	4	3	0	0.395	0.996	1.000
234	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(2), ACOX3(1), ELOVL6(3), FADS2(1), FASN(5), PECR(1), SCD(2)	10405150	17	10	17	6	5	0	2	4	6	0	0.587	0.996	1.000
235	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(2), HK2(4), HK3(4), IMPA1(2), PGM3(1)	7527964	17	9	17	4	9	2	1	3	2	0	0.211	0.996	1.000
236	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(2), CAPNS1(2), GSK3B(1), PPP2CA(2)	6791163	7	5	7	4	3	1	0	1	2	0	0.885	0.996	1.000
237	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(1), HLA-DRA(1), IFNGR2(1), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3)	9366151	12	9	12	4	2	1	1	3	5	0	0.645	0.996	1.000
238	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(1), B3GALT5(3), FUT1(1), FUT2(1), GBGT1(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1)	7893220	16	14	16	8	7	5	0	2	2	0	0.721	0.997	1.000
239	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), SP1(2), SP3(3), SYT1(1)	15469956	24	18	24	6	7	2	1	7	7	0	0.344	0.997	1.000
240	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(3), ITGAL(5), ITGAM(3), ITGB2(2), SELE(1), SELP(4)	11703103	19	17	18	7	9	1	5	3	1	0	0.400	0.997	1.000
241	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(3), C6(5), C8A(3), C9(3)	9284566	17	11	17	8	5	2	1	4	5	0	0.751	0.997	1.000
242	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(3), FBP1(2), FBP2(1), GOT1(2), GOT2(1), MDH1(1), ME1(3), ME2(1), ME3(1), PKLR(1), TKT(2)	13251252	18	10	18	3	4	4	3	5	2	0	0.0858	0.998	1.000
243	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1)	9870752	16	11	16	4	7	3	2	3	1	0	0.287	0.998	1.000
244	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNB1(1), NFKB1(3), RELA(3), TNFSF11(1), TRAF6(2)	8145196	10	5	10	2	2	3	1	2	2	0	0.286	0.998	1.000
245	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(6), JAK2(1), PLA2G2A(1), PTPRU(4), REG1A(1), STAT1(1)	8491773	14	10	14	5	3	4	1	4	2	0	0.562	0.998	1.000
246	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), PRKAG1(3), PRKAR2A(1)	7444424	9	4	9	2	3	2	2	2	0	0	0.326	0.998	1.000
247	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(2), ADORA3(3), P2RY1(1), P2RY2(2), P2RY6(1)	4409058	12	9	12	6	5	2	1	3	1	0	0.651	0.998	1.000
248	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), DHRS1(1), DHRS7(1), DHRSX(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1)	18432810	22	14	22	4	8	1	3	5	5	0	0.121	0.998	1.000
249	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCR(2), GRB2(1), HRAS(4), JAK2(1), MAP2K4(4), MAP3K1(5), MYC(1), PIK3CA(16), PIK3R1(2), RAF1(1), SOS1(4), STAT1(1), STAT5B(2)	20758473	47	35	41	10	11	11	8	12	5	0	0.0446	0.998	1.000
250	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), UGDH(2)	6265694	10	9	10	5	1	1	3	4	1	0	0.851	0.998	1.000
251	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2)	9769159	15	12	15	5	3	2	3	5	2	0	0.519	0.998	1.000
252	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(3), FURIN(1), NOTCH1(6)	6773733	10	5	10	5	5	1	1	1	1	1	0.639	0.998	1.000
253	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFA5(1), NDUFB7(1), NDUFS2(2), NDUFV1(1)	5118808	7	6	7	3	1	1	3	2	0	0	0.736	0.999	1.000
254	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(10), MAP2(4), PPP1CA(1), PPP2CA(2), PRKAG1(3), PRKAR2A(1), PRKCE(2)	13446229	23	16	23	8	1	3	4	10	5	0	0.736	0.999	1.000
255	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(1), IL4(1), IL4R(3), IRS1(3), JAK1(6), JAK3(1), SHC1(3), STAT6(3)	10820307	24	20	23	9	7	4	2	7	4	0	0.655	0.999	1.000
256	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(1), ENPP1(3), ENPP3(2), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5E(1), NT5M(1)	10732148	15	15	15	8	3	3	1	5	3	0	0.833	0.999	1.000
257	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(2), GREB1(2), MTA1(2), TUBA8(1)	7905096	9	8	9	6	3	1	3	0	2	0	0.849	0.999	1.000
258	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT3(2), CHPF(1), CHST11(3), CHST12(1), CHST13(1), CHST3(3), CHSY1(1), DSE(1), UST(1), XYLT1(6), XYLT2(1)	10025365	22	20	22	8	12	3	1	3	3	0	0.377	0.999	1.000
259	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(1), PRKCA(2)	4925307	5	5	5	7	2	1	0	1	1	0	0.989	0.999	1.000
260	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), FHL5(4), FSHR(2), GNAS(2)	7049295	10	8	10	4	2	2	2	4	0	0	0.764	0.999	1.000
261	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(1), DHRS7(1), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1)	11060009	19	11	19	7	7	2	2	4	4	0	0.558	0.999	1.000
262	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(3), MBTPS1(3), MBTPS2(1), SCAP(2), SREBF1(2), SREBF2(2)	8745598	14	10	14	8	5	1	0	5	3	0	0.905	0.999	1.000
263	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(2), HK2(4), HK3(4), IMPA1(2), PGM3(1)	8571630	17	9	17	4	9	2	1	3	2	0	0.193	0.999	1.000
264	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR7(3), CD28(2), CD4(1), IFNGR2(1), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3), TGFB2(2)	14647280	26	20	26	7	3	2	3	12	6	0	0.441	0.999	1.000
265	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), JAK1(6), JAK2(1), JAK3(1), PIAS3(2), PTPRU(4), REG1A(1), STAT3(6)	11199244	22	16	22	9	3	6	3	6	4	0	0.648	0.999	1.000
266	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PCYT1A(1), PCYT1B(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1)	10296349	14	9	14	8	3	3	2	3	3	0	0.883	0.999	1.000
267	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(1), AKT3(1), CDKN1A(2), GRB2(1), HRAS(4), NTRK1(9), PIK3CA(16), PIK3CD(5), SHC1(3), SOS1(4)	11815721	49	38	43	14	19	10	6	8	6	0	0.148	0.999	1.000
268	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY2(4), CSNK1E(3), NPAS2(1), NR1D1(3), PER1(4), PER2(4), PER3(2)	12567640	22	15	22	6	8	5	1	6	2	0	0.312	0.999	1.000
269	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(4), CALCRL(1), CD97(2), CRHR2(2), ELTD1(1), EMR2(7), GHRHR(1), GIPR(2), GLP1R(1), GLP2R(1), GPR64(1), LPHN1(3), LPHN2(6), LPHN3(9), SCTR(3)	19531472	46	38	45	12	14	6	5	13	8	0	0.112	0.999	1.000
270	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(4), GLI2(3), GLI3(3), GSK3B(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), SHH(2), SUFU(1)	12250592	23	16	23	7	5	3	3	8	4	0	0.380	0.999	1.000
271	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	HRAS(4), MAPK1(1), MYC(1), NFKB1(3), PLCB1(3), PRKCA(2), RAF1(1), RELA(3), TNF(1)	11456384	19	15	17	6	6	4	5	4	0	0	0.320	0.999	1.000
272	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(10), ATF2(3), AXIN1(1), BMP10(1), BMP2(2), BMP4(1), BMP5(4), BMP7(3), BMPR1A(2), BMPR2(3), CHRD(1), CTNNB1(13), DVL1(1), FZD1(2), GATA4(1), GSK3B(1), MAP3K7(2), MEF2C(3), NPPA(1), RFC1(5), TGFB2(2), TGFBR1(2), TGFBR3(1), WNT1(1)	26818699	66	46	63	14	12	12	12	15	15	0	0.0345	1.000	1.000
273	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(8), EP300(7), LPL(1), NCOA1(1), NCOA2(2), PPARG(1), RXRA(2)	13659850	22	16	22	8	7	3	4	6	2	0	0.515	1.000	1.000
274	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(1), FUT3(2), ST3GAL3(1)	3754195	5	5	5	3	1	2	1	1	0	0	0.800	1.000	1.000
275	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(1), CSF1(1), HLA-DRA(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL1A(1), IL4(1), IL6(1), IL7(2), PDGFA(2), TGFB2(2), TNF(1)	9712960	17	14	17	8	6	2	2	3	4	0	0.707	1.000	1.000
276	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(1), DHRS1(1), DHRS7(1), DHRSX(5), ECHS1(1), EHHADH(5), ESCO1(5), ESCO2(1), GCDH(1), NAT6(1), SH3GLB1(1)	19176942	25	19	25	5	11	1	2	6	5	0	0.161	1.000	1.000
277	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(2), CBS(1), CTH(2), HEMK1(1), LCMT1(1), LCMT2(1), MARS2(1), MAT1A(3), METTL6(1), PAPSS2(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), SEPHS1(1), SEPHS2(3)	18352130	26	19	26	8	6	5	4	5	6	0	0.418	1.000	1.000
278	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT5(1), DDOST(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(1), MGAT3(1), MGAT4A(1), MGAT5(1), RPN1(1), RPN2(2), ST6GAL1(1)	14623681	22	17	22	6	6	6	1	8	1	0	0.342	1.000	1.000
279	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), PDE1B(1), PLCB1(3), PLCB2(1), PRL(1)	8190295	8	7	8	4	2	1	1	2	2	0	0.720	1.000	1.000
280	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(6), JAK2(1), JAK3(1), PIAS3(2), PTPRU(4), REG1A(1)	10106977	15	10	15	9	3	4	2	3	3	0	0.912	1.000	1.000
281	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(8), ABCB11(3), ABCB4(2), ABCC1(1), ABCC3(2), GSTP1(1)	10565247	17	11	17	8	7	4	1	3	2	0	0.721	1.000	1.000
282	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3D(1), ETV5(2), IL12A(1), IL12B(1), IL12RB2(1), JAK2(1), MAP2K6(1), STAT4(6), TYK2(2)	13663851	18	14	18	7	2	5	2	4	5	0	0.569	1.000	1.000
283	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(1), ACO2(1), ACSS1(1), ACSS2(1), FH(3), IDH1(6), MDH1(1), SUCLA2(1)	9798005	17	13	14	6	4	3	3	5	2	0	0.460	1.000	1.000
284	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(2), EPOR(1), GRIN1(3), HIF1A(2), JAK2(1), NFKB1(3), RELA(3), SOD2(1)	9324828	18	11	18	5	7	5	1	3	2	0	0.369	1.000	1.000
285	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(3), MAP3K1(5), NCOR2(7), RARA(1), RXRA(2), THRA(6)	12633639	27	16	27	7	12	3	1	8	3	0	0.197	1.000	1.000
286	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(2), MPO(3), PRDX1(1), TPO(5), TYR(2)	7090384	17	13	17	7	10	2	0	5	0	0	0.582	1.000	1.000
287	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BTK(1), CAD(9), CASP10(1), CASP8(1), DAXX(2), DEDD2(2), DFFA(4), EGFR(3), EPHB2(4), FAF1(4), IL1A(1), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAP3K5(2), MAPK1(1), MAPK8IP3(4), MET(4), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PFN1(1), PFN2(3), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(5), TNFRSF6B(1), TP53(59), TPX2(1), TRAF2(5), TUFM(1)	53425842	143	97	127	28	45	20	16	28	33	1	0.00243	1.000	1.000
288	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(5), ITGAM(3), ITGB2(2), SELE(1)	7591645	12	11	11	6	7	1	1	2	1	0	0.626	1.000	1.000
289	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(3), RELA(3), TNFAIP3(1), TRAF6(2)	13318564	18	9	18	3	6	6	1	2	3	0	0.0673	1.000	1.000
290	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), FYN(1), LRP8(2), RELN(10), VLDLR(3)	10367157	18	12	18	8	4	4	3	6	1	0	0.759	1.000	1.000
291	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(7), CPT1A(1), LEPR(2), PRKAA2(5), PRKAG1(3)	10717499	18	16	18	6	4	4	4	5	0	1	0.469	1.000	1.000
292	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(3), RELA(3), RIPK1(1), TANK(1), TNFAIP3(1), TNFRSF1B(1), TRAF1(1), TRAF2(5)	16493720	25	16	25	5	9	7	3	4	2	0	0.0679	1.000	1.000
293	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), FDXR(2), SHMT1(1)	11790670	19	14	19	6	5	3	2	5	4	0	0.549	1.000	1.000
294	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(5), E2F1(3), ETS1(1), ETV3(5), HDAC2(1), HDAC5(4), HRAS(4), NCOR2(7), RBL1(2), RBL2(2), SIN3A(1), SIN3B(2)	18990684	38	26	36	9	13	6	8	4	7	0	0.0848	1.000	1.000
295	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR3(1), NCKAP1(1), NTRK1(9), RAC1(1), WASF1(2), WASF2(2), WASF3(1)	11278021	18	14	18	6	7	5	1	3	2	0	0.508	1.000	1.000
296	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(10), ASAH1(1), CERK(1), CREB1(1), DAG1(2), EPHB2(4), ITPKB(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK8IP3(4)	21030077	34	27	34	10	12	4	0	6	12	0	0.361	1.000	1.000
297	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(5), EGF(3), EGFR(3), GRB2(1), MET(4), PDGFRA(3), PRKCA(2), SH3GLB1(1), SH3GLB2(2)	14333269	25	20	25	8	8	3	4	10	0	0	0.363	1.000	1.000
298	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), CR2(2), HLA-DRA(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8)	11166290	20	19	19	9	9	3	2	5	1	0	0.704	1.000	1.000
299	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(5), ATM(22), BUB1(2), BUB1B(3), BUB3(1), CCNA1(1), CCNB2(1), CCND3(1), CCNE2(1), CCNH(1), CDAN1(1), CDC14B(2), CDC20(2), CDC25A(4), CDC25B(5), CDC6(1), CDC7(2), CDH1(4), CDKN1A(2), CDKN2A(1), DTX4(2), E2F1(3), E2F3(1), EP300(7), ESPL1(3), GSK3B(1), HDAC1(1), HDAC2(1), HDAC3(2), HDAC4(3), HDAC5(4), HDAC6(4), HDAC8(2), MAD1L1(4), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MPEG1(5), PCNA(2), PLK1(1), PRKDC(11), PTPRA(5), PTTG1(1), RB1(3), RBL1(2), SMAD4(7), TFDP1(2), TP53(59), WEE1(1)	80459909	216	137	201	33	59	38	28	47	42	2	2.56e-06	1.000	1.000
300	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(4), GLB1(2), HEXB(2), LCT(6)	10492890	16	13	16	6	9	2	0	4	1	0	0.459	1.000	1.000
301	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), HMGCR(1), LSS(2), MVK(1), NQO1(2), SQLE(1)	8059595	8	8	8	6	5	0	0	2	1	0	0.906	1.000	1.000
302	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGTR1(3), BDKRB2(2), NOS3(2)	7163967	11	8	11	8	4	4	0	2	1	0	0.923	1.000	1.000
303	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(3), DERA(1), FBP1(2), FBP2(1), H6PD(3), PFKL(2), PFKM(3), PFKP(3), PGM3(1), PRPS1L1(4), RBKS(2), TKT(2), TKTL2(4)	17897029	31	22	31	9	9	5	6	6	5	0	0.228	1.000	1.000
304	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(1), AKT3(1), ANKRD6(2), APC(10), AXIN1(1), AXIN2(5), CTNNB1(13), DACT1(4), DKK1(3), DKK2(2), DVL1(1), GSK3A(3), GSK3B(1), LRP1(12), MVP(2), NKD2(1), PTPRA(5), WIF1(2)	29600157	72	47	68	14	18	16	9	15	14	0	0.00630	1.000	1.000
305	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(5), CNR2(1), DNMT1(3), MTNR1A(1), MTNR1B(2), PTGER2(2), PTGER4(1), PTGIR(3), TBXA2R(5)	8210197	24	14	24	8	14	4	1	2	3	0	0.134	1.000	1.000
306	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3)	17280021	27	19	27	6	9	7	2	6	3	0	0.151	1.000	1.000
307	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AGPS(1), ENPP2(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2A(1), PPAP2B(1)	17069299	27	18	27	8	8	3	0	7	9	0	0.446	1.000	1.000
308	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(3), PGAP1(1), PIGA(1), PIGB(2), PIGC(1), PIGG(3), PIGH(1), PIGK(1), PIGO(2), PIGQ(3), PIGT(1)	17504899	19	13	19	6	5	3	3	4	4	0	0.492	1.000	1.000
309	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), NFKB1(3), RELA(3), TNF(1), XDH(1)	7249489	9	4	9	4	3	4	1	1	0	0	0.590	1.000	1.000
310	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(2), GPX2(2), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), IDH1(6), MGST1(1)	13305103	19	15	16	5	8	3	1	7	0	0	0.296	1.000	1.000
311	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(10), CDH1(4), CREBBP(8), EP300(7), MAP3K7(2), TGFB2(2), TGFBR1(2)	18974735	35	29	35	10	7	4	5	7	12	0	0.445	1.000	1.000
312	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), PRF1(2)	9545885	14	9	14	6	2	4	0	7	1	0	0.783	1.000	1.000
313	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(4), GNE(1), GNPDA1(1), HEXB(2), HK1(2), HK2(4), HK3(4), PGM3(1), UAP1(1)	12453907	21	10	21	4	10	4	1	3	3	0	0.128	1.000	1.000
314	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), FUT1(1), FUT2(1), FUT3(2), FUT4(1), ST3GAL6(1), ST8SIA1(1)	11910347	20	13	20	8	6	4	2	6	1	1	0.676	1.000	1.000
315	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(3), FBP1(2), FBP2(1), H6PD(3), PFKM(3), PFKP(3), PGM3(1), PRPS1L1(4), RBKS(2), TKT(2)	15057169	24	18	24	7	6	4	5	6	3	0	0.321	1.000	1.000
316	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	GRB2(1), HRAS(4), KLK2(1), PIK3CA(16), PIK3R1(2), PLCG1(1), RAF1(1), SHC1(3), SOS1(4)	14017545	33	28	28	10	11	5	7	6	4	0	0.377	1.000	1.000
317	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), RPL10A(3), RPL10L(2), RPL11(4), RPL12(1), RPL19(2), RPL28(1), RPL29(1), RPL3(1), RPL34(1), RPL35A(1), RPL36AL(1), RPL37(1), RPL3L(1), RPL6(2), RPL7(2), RPL8(1), RPS10(1), RPS11(2), RPS20(1), RPS5(1), RPS6(1), RPS9(1)	16796571	33	24	33	7	9	7	3	10	4	0	0.209	1.000	1.000
318	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6)	12333606	19	13	19	9	6	6	2	2	3	0	0.832	1.000	1.000
319	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(3), AOC3(1), CES1(3), DDHD1(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1)	18634387	21	16	21	5	3	2	4	8	4	0	0.339	1.000	1.000
320	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(7), ACACB(3), FASN(5)	11469712	15	11	15	8	3	1	2	7	1	1	0.885	1.000	1.000
321	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), HMGCR(1), HMGCS1(1), LSS(2), MVK(1), SQLE(1)	9625901	7	7	7	8	4	0	0	2	1	0	0.991	1.000	1.000
322	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(2), GOSR1(2), SNAP25(1), STX16(3), STX7(1), STX8(2), USE1(1), VAMP1(1), VAMP5(1), VAMP7(2), VTI1A(1), YKT6(1)	12249243	19	11	19	7	9	1	2	3	4	0	0.624	1.000	1.000
323	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG5(2), ATG7(1), BECN1(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), PIK3C3(1), PIK3R4(2), PRKAA2(5), ULK1(1), ULK2(1), ULK3(2)	15555851	24	18	24	9	7	3	5	6	3	0	0.625	1.000	1.000
324	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(1), DHFR(2), MTHFD2(1), POLD1(3), POLG(2), SRM(1)	9176002	11	5	11	7	4	4	2	0	1	0	0.839	1.000	1.000
325	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), EPX(4), GOT1(2), GOT2(1), HPD(2), LPO(2), MAOA(2), MAOB(2), MPO(3), PRDX1(1), TPO(5)	16042176	32	25	32	10	11	6	1	11	3	0	0.388	1.000	1.000
326	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), OPRK1(1), POLR2A(6), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	9460940	15	6	15	5	7	4	1	3	0	0	0.357	1.000	1.000
327	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), ARHGDIB(1), BIRC2(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), DFFA(4), LMNA(4), LMNB2(2), PRF1(2)	14261144	21	11	21	4	5	8	0	6	2	0	0.151	1.000	1.000
328	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), AOC2(3), AOC3(1), AOX1(2), ASMT(2), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), ECHS1(1), EHHADH(5), GCDH(1), KMO(2), KYNU(3), MAOA(2), MAOB(2), SDS(1), TDO2(1), TPH1(1), WARS(1), WARS2(2)	40556129	81	60	80	17	27	9	11	22	12	0	0.0433	1.000	1.000
329	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(22), CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CCNH(1), CDC25A(4), CDK7(2), CDKN1A(2), CDKN1B(6), CDKN2A(1), CREB3L1(1), CREB3L3(1), CREB3L4(2), E2F1(3), E2F3(1), GBA2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MYC(1), MYT1(2), NACA(3), PCNA(2), POLA2(1), POLE(6), POLE2(1), RB1(3), RBL1(2), RPA1(2), RPA2(1), TFDP1(2), TFDP2(1), TNXB(12), TP53(59), WEE1(1)	56917286	164	110	149	31	42	29	17	34	40	2	0.00129	1.000	1.000
330	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(1), CASP10(1), CASP8(1), CASP9(1), DFFA(4), PRF1(2), SCAP(2), SREBF1(2), SREBF2(2)	13435706	18	8	18	6	4	5	0	8	1	0	0.517	1.000	1.000
331	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(2), CD36(1), CITED2(1), CPT1B(2), CREBBP(8), DUSP1(1), EHHADH(5), EP300(7), HSD17B4(3), LPL(1), MAPK1(1), ME1(3), MRPL11(1), MYC(1), NCOA1(1), NCOR1(8), NCOR2(7), NR1H3(1), NR2F1(1), NRIP1(4), PDGFA(2), PIK3CA(16), PIK3R1(2), PPARA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PTGS2(5), RB1(3), RELA(3), RXRA(2), SP1(2), STAT5B(2), TNF(1)	46561431	108	70	105	23	30	22	12	22	21	1	0.00608	1.000	1.000
332	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(3), ALG12(1), ALG13(1), ALG14(2), ALG5(1), ALG8(1), ALG9(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), DDOST(1), DPM1(2), FUT8(2), GANAB(3), MAN1A1(2), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT3(1), MGAT4A(1), MGAT5(1), MGAT5B(2), RFT1(2), RPN1(1), RPN2(2), ST6GAL1(1)	30971637	42	26	42	9	9	8	3	11	11	0	0.208	1.000	1.000
333	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), MAP2K4(4), MAP3K1(5), MAPK1(1), NFKB1(3), NSMAF(4), RAF1(1), RELA(3), RIPK1(1), TNFRSF1A(1), TRAF2(5)	15053753	29	17	29	9	9	9	3	7	1	0	0.264	1.000	1.000
334	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(3), DLAT(1), DLD(2), FH(3), IDH3A(1), IDH3B(1), MDH1(1), PC(2), PDHA1(1), PDHA2(4), PDHX(1), PDK1(2), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(3), SDHB(2), SDHC(2), SUCLA2(1)	20860720	36	24	35	9	3	11	3	10	9	0	0.128	1.000	1.000
335	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(3), FBP1(2), FBP2(1), GOT1(2), GOT2(1), MDH1(1), ME1(3), ME3(1), PGK2(2), PKLR(1), TKT(2), TKTL2(4)	14830288	23	14	23	5	6	5	4	5	3	0	0.101	1.000	1.000
336	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(1), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), GLUD1(2), NAGS(1), ODC1(1), OTC(1), PYCR1(2)	12840380	20	17	20	9	8	3	1	6	2	0	0.724	1.000	1.000
337	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(4), GLB1(2), HEXB(2), HGSNAT(1), HPSE(3), HYAL2(2), LCT(6), SPAM1(3)	14978624	25	16	25	9	13	5	0	5	2	0	0.443	1.000	1.000
338	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(2), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(1), EDNRA(1), HPGD(1), HSD11B1(1), PLA2G4A(4), PRL(1), PTGER2(2), PTGER4(1), PTGIR(3), PTGIS(2), PTGS1(2), PTGS2(5), SCGB1A1(2), TBXAS1(2)	15290187	35	23	35	11	11	7	2	6	9	0	0.300	1.000	1.000
339	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH5A1(1), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HMGCL(1), L2HGDH(1), OXCT1(5), PDHA1(1), PDHA2(4), SDHB(2), SDS(1)	19013619	51	38	48	15	16	11	6	10	8	0	0.157	1.000	1.000
340	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(3), IKBKB(1), IL4(1), MAP3K1(5), MAP3K5(2), MAP4K5(1), NFKB1(3), RELA(3), TRAF2(5)	14232233	24	13	24	5	9	7	1	5	2	0	0.117	1.000	1.000
341	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), CP(5), CPOX(1), EPRS(4), HMBS(1), HMOX1(2), HMOX2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1)	20247639	27	21	27	7	10	4	1	9	3	0	0.299	1.000	1.000
342	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(1), IL4(1), TGFB2(2), TGFBR1(2), TGFBR3(1), TOB1(1), TOB2(1)	7805360	11	9	11	7	1	3	4	2	1	0	0.868	1.000	1.000
343	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX5(1), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2J2(1), CYP2U1(2), CYP4A11(1), CYP4A22(2), CYP4F2(2), CYP4F3(2), DHRS4(1), GPX2(2), GPX6(1), LTC4S(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2)	28592782	59	40	59	11	18	11	6	14	10	0	0.0122	1.000	1.000
344	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(4), EPHB1(8), FYN(1), ITGA1(2), L1CAM(6), LYN(2), SELP(4)	11624514	28	22	28	11	7	4	4	9	4	0	0.586	1.000	1.000
345	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(10), AXIN1(1), CREBBP(8), CTNNB1(13), DVL1(1), EP300(7), FZD1(2), GSK3B(1), HDAC1(1), LEF1(2), PITX2(3), TRRAP(5), WNT1(1)	24493567	55	43	52	14	15	7	9	13	11	0	0.104	1.000	1.000
346	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CAMK1(3), CAMK1G(2), FPR1(3), GNB1(1), GNGT1(1), HRAS(4), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAPK1(1), NCF1(1), NCF2(3), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(1), PLCB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAC1(1), RAF1(1), RELA(3), SYT1(1)	28027341	52	34	50	14	14	9	7	13	9	0	0.186	1.000	1.000
347	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C1(1), AKR1C3(1), AKR1C4(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A43(1), CYP3A7(1), EPHX1(3), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), MGST1(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3)	42399490	79	55	79	15	20	9	11	29	10	0	0.0210	1.000	1.000
348	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(1), CALM1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYNJ1(3), SYNJ2(3), SYT1(1)	16003282	22	17	22	8	5	3	2	8	4	0	0.627	1.000	1.000
349	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AOC2(3), AOC3(1), CNDP1(3), DPYD(3), DPYS(2), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HIBCH(1), SRM(1)	19895388	40	33	40	13	15	7	5	7	6	0	0.322	1.000	1.000
350	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), GNAS(2), PLCE1(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RAP2B(1)	10870168	16	13	16	9	4	1	1	9	1	0	0.939	1.000	1.000
351	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(3), AKT2(1), AKT3(1), BTK(1), CDKN2A(1), DAPP1(1), GRB2(1), GSK3A(3), GSK3B(1), IARS(2), IGFBP1(1), INPP5D(3), PDK1(2), PIK3CA(16), PPP1R13B(3), PTEN(17), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1), TEC(1), YWHAB(1), YWHAQ(2), YWHAZ(1)	26598278	75	53	71	17	16	10	7	20	22	0	0.132	1.000	1.000
352	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), EGR3(1), MAP3K1(5), MYC(1), NFATC1(2), NFATC2(2), NFKB1(3), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RELA(3), SYT1(1)	20608502	32	17	32	9	9	7	3	9	4	0	0.202	1.000	1.000
353	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), GRB2(1), HRAS(4), IL3RA(3), JAK2(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2)	13052662	20	15	18	8	7	4	5	0	4	0	0.475	1.000	1.000
354	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1(3), CAMK1G(2), CAMK2A(1), CAMK2D(2), CAMK4(4), HDAC5(4), MEF2A(1), MEF2C(3), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYT1(1)	14817884	30	18	30	10	11	4	1	9	5	0	0.467	1.000	1.000
355	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD2(1), GRM1(9), PLCB1(3), PPP1CA(1), PPP2CA(2), PPP3CA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	11835042	25	19	24	10	8	5	1	7	4	0	0.657	1.000	1.000
356	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(1), CALM1(1), CAMK1(3), CAMK1G(2), HDAC5(4), IGF1R(4), MAP2K6(1), MEF2A(1), MEF2C(3), MEF2D(1), NFATC1(2), NFATC2(2), PIK3CA(16), PIK3R1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYT1(1)	25533994	52	35	48	16	14	9	7	17	5	0	0.280	1.000	1.000
357	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(1), CS(3), DLD(2), FH(3), IDH1(6), IDH3A(1), IDH3B(1), MDH1(1), PC(2), SDHA(3), SDHB(2), SUCLA2(1)	15167146	27	17	24	7	7	5	4	7	4	0	0.168	1.000	1.000
358	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(2), CREB1(1), EP300(7), HIF1A(2), NOS3(2), P4HB(1), VHL(3)	12480708	20	12	20	8	10	4	1	3	2	0	0.586	1.000	1.000
359	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADSB(3), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(3), DPYS(2), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), SDS(1)	21433687	46	36	45	14	16	8	7	7	8	0	0.233	1.000	1.000
360	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(3), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), NOS1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), SYT1(1)	18780418	47	33	47	17	17	6	1	18	5	0	0.400	1.000	1.000
361	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM1(1), FCER1A(1), GRB2(1), HRAS(4), LYN(2), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAPK1(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(2), PIK3CA(16), PIK3R1(2), PLA2G4A(4), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(1), SHC1(3), SOS1(4), SYK(2), SYT1(1), VAV1(3)	31698962	74	53	69	18	23	12	8	20	11	0	0.0967	1.000	1.000
362	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(3), EGFR(3), HGS(2), TF(1), TFRC(1)	9503241	14	10	14	8	1	1	3	8	1	0	0.949	1.000	1.000
363	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AKT1(3), AKT2(1), AKT3(1), APAF1(2), ATM(22), BIRC2(1), CAPN1(2), CAPN2(2), CASP10(1), CASP8(1), CASP9(1), CFLAR(2), CSF2RB(1), DFFA(4), FAS(1), FASLG(1), IKBKB(1), IL1A(1), IL1RAP(2), IL3RA(3), IRAK1(1), IRAK2(4), IRAK3(4), IRAK4(2), NFKB1(3), NTRK1(9), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RELA(3), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(1), TP53(59), TRAF2(5)	61295807	205	137	186	41	57	41	22	48	36	1	0.000412	1.000	1.000
364	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), FLT1(5), FLT4(4), HIF1A(2), HRAS(4), KDR(7), NOS3(2), PIK3CA(16), PIK3R1(2), PLCG1(1), PRKCA(2), PTK2(3), PXN(1), SHC1(3), VHL(3)	25016966	62	41	57	18	20	11	8	12	10	1	0.250	1.000	1.000
365	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(2), GPX2(2), GPX6(1), GSR(1), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), IDH1(6), MGST1(1), OPLAH(2)	16213894	23	17	20	7	10	4	1	7	1	0	0.307	1.000	1.000
366	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOC(3), FBP1(2), FBP2(1), GCK(4), GMDS(1), GMPPB(3), HK1(2), HK2(4), HK3(4), KHK(1), MPI(1), PFKFB1(2), PFKFB4(1), PFKM(3), PFKP(3), PMM1(1)	17487806	36	22	36	13	16	2	5	8	5	0	0.345	1.000	1.000
367	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(2), ARSD(1), ARSE(2), ASAH1(1), GAL3ST1(2), GALC(1), GLB1(2), LCT(6), NEU1(1), NEU2(2), NEU4(2), PPAP2A(1), PPAP2B(1), SMPD2(2), SPTLC1(1), SPTLC2(1)	17724889	28	23	28	10	12	3	3	7	3	0	0.412	1.000	1.000
368	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPPL1(1), ITPKB(2), OCRL(3), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3CA(16), PIK3CB(3), PIK3CG(7), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCG1(1), PLCG2(3)	32883312	65	43	62	13	19	17	7	17	5	0	0.0189	1.000	1.000
369	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA1(1), CA12(1), CA14(2), CA2(3), CA3(1), CA4(2), CA5A(1), CA6(1), CA8(4), CA9(2), CPS1(4), CTH(2), GLUD1(2), GLUL(1), HAL(2)	14022589	30	26	30	10	8	6	1	10	5	0	0.499	1.000	1.000
370	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(3), EGFR(3), GRB2(1), HRAS(4), JAK1(6), MAP2K4(4), MAP3K1(5), PIK3CA(16), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6)	27583486	63	45	58	19	16	10	9	21	7	0	0.303	1.000	1.000
371	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	GRB2(1), HRAS(4), JAK1(6), MAP2K4(4), MAP3K1(5), PDGFA(2), PDGFRA(3), PIK3CA(16), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6)	25689918	62	42	57	17	19	12	9	15	7	0	0.136	1.000	1.000
372	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	GRB2(1), HRAS(4), IRS1(3), PIK3CA(16), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(1), SHC1(3), SOS1(4)	18702166	36	28	31	12	13	5	7	7	4	0	0.446	1.000	1.000
373	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR3(1), AKT1(3), ANGPTL2(1), DAG1(2), DGKA(1), ETFA(1), ITGA9(4), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), MAPK1(1), NR1I3(2), PAK1(1), PDE3A(2), PDE3B(3), PI3(1), PIK3C2G(1), PIK3CA(16), PIK3CD(5), PIK3R1(2), PSME1(1), RIPK3(1)	35793431	69	53	65	16	19	14	6	18	12	0	0.0903	1.000	1.000
374	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(8), DUSP1(1), EP300(7), IKBKB(1), MAP2K3(1), MAP2K6(1), MAP3K7(2), NFKB1(3), RELA(3), TGFBR1(2), TLR2(2), TNF(1)	21833709	32	22	32	9	10	7	5	7	3	0	0.260	1.000	1.000
375	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(3), APC(10), ASAH1(1), CAV3(1), DAG1(2), DLG4(3), EPHB2(4), GNAI1(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PITX2(3), PTX3(1), RAC1(1), RHO(1), RYR1(20)	33703560	74	56	73	19	33	7	4	13	17	0	0.0639	1.000	1.000
376	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CRK(1), GNAI1(2), GNB1(1), GNGT1(1), HRAS(4), MAPK1(1), NFKB1(3), PIK3C2G(1), PIK3CA(16), PIK3R1(2), PLCG1(1), PRKCA(2), PTK2(3), PXN(1), RAF1(1), RELA(3)	20214252	46	32	41	14	12	9	9	12	4	0	0.346	1.000	1.000
377	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(2), AKT1(3), CAMK2A(1), CAMK2D(2), CREB1(1), GNAS(2), GRB2(1), HRAS(4), MAPK1(1), PIK3CA(16), PIK3R1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), RAC1(1), RPS6KA1(2), RPS6KA5(3), SOS1(4)	21475239	54	39	48	14	15	9	9	17	4	0	0.187	1.000	1.000
378	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(5), ARPC5(1), ARPC5L(1), CD14(2), CDH1(4), CLDN1(1), CTNNB1(13), CTTN(1), FYN(1), HCLS1(1), KRT18(1), LY96(1), NCL(1), PRKCA(2), RHOA(2), ROCK1(5), ROCK2(1), TLR4(2), TLR5(2), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2), WAS(2), YWHAQ(2), YWHAZ(1)	38692018	78	54	73	19	16	12	8	30	12	0	0.0983	1.000	1.000
379	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(5), ARPC5(1), ARPC5L(1), CD14(2), CDH1(4), CLDN1(1), CTNNB1(13), CTTN(1), FYN(1), HCLS1(1), KRT18(1), LY96(1), NCL(1), PRKCA(2), RHOA(2), ROCK1(5), ROCK2(1), TLR4(2), TLR5(2), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2), WAS(2), YWHAQ(2), YWHAZ(1)	38692018	78	54	73	19	16	12	8	30	12	0	0.0983	1.000	1.000
380	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(10), AR(2), ASAH1(1), BRAF(8), CCL15(1), DAG1(2), EGFR(3), GNA11(1), GNAI1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PHKA2(2), PIK3CA(16), PIK3CD(5), PIK3R1(2), PITX2(3), PTX3(1), RAF1(1)	39186301	86	68	81	21	23	12	8	25	18	0	0.0933	1.000	1.000
381	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPOR(1), GRB2(1), HRAS(4), JAK2(1), PLCG1(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2)	15744634	18	15	16	9	8	3	4	0	3	0	0.727	1.000	1.000
382	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	BTG1(1), CEBPB(1), CLOCK(1), CRY2(4), DNAJA1(1), EIF4G2(1), ETV6(1), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(7), NCKAP1(1), NCOA4(3), NR1D2(2), PER1(4), PER2(4), PPP2CB(1), PSMA4(1), SF3A3(1), SUMO3(1), TOB1(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(2), ZFR(4)	26925021	48	32	48	15	10	6	7	15	10	0	0.562	1.000	1.000
383	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(3), ACADVL(1), ACAT1(2), ACAT2(1), ACOX1(2), ACOX3(1), ACSL1(3), ACSL5(1), ACSL6(3), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), CYP4A11(1), CYP4A22(2), ECHS1(1), EHHADH(5), GCDH(1), HADH(3), HADHB(1), HSD17B4(3)	36136855	64	42	63	15	24	8	8	12	12	0	0.0418	1.000	1.000
384	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BIRC2(1), CASP10(1), CASP8(1), CASP9(1), CFLAR(2), DFFA(4), LMNA(4), NFKB1(3), RELA(3), RIPK1(1), SPTAN1(2), TNFRSF10A(1), TNFRSF10B(2), TNFSF12(1), TRAF2(5)	24522172	34	19	34	8	9	11	2	10	2	0	0.154	1.000	1.000
385	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), CBL(1), CFLAR(2), E2F1(3), GRB2(1), HRAS(4), IL2RB(1), IRS1(3), JAK1(6), JAK3(1), MAPK1(1), MYC(1), NMI(1), PIK3CA(16), PIK3R1(2), PPIA(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2), SYK(2)	26550520	59	42	53	19	17	11	8	12	11	0	0.332	1.000	1.000
386	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(3), AKT2(1), AKT3(1), DAG1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PDK1(2), PHKA2(2), PIK3CB(3), PITX2(3), PLD1(3), PLD2(2), VN1R1(2)	33003130	51	37	50	10	13	13	3	14	8	0	0.0309	1.000	1.000
387	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	GRB2(1), HRAS(4), JAK2(1), PIK3CA(16), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6), STAT5B(2), THPO(1)	22151049	46	33	41	13	13	9	8	11	5	0	0.232	1.000	1.000
388	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(5), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GCNT1(2), ST3GAL1(2), WBSCR17(2)	10631557	20	13	20	9	9	2	0	7	2	0	0.763	1.000	1.000
389	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), CREB1(1), DUSP1(1), EEF2K(5), EIF4E(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K10(4), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), NFKB1(3), TRAF6(2)	24427549	37	21	36	12	14	8	2	6	7	0	0.327	1.000	1.000
390	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(3), ALAS2(1), BLVRB(1), COX15(2), CP(5), CPOX(1), EARS2(1), EPRS(4), FTMT(2), HMBS(1), HMOX1(2), HMOX2(1), MMAB(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3)	31098922	53	36	53	15	17	7	4	18	7	0	0.282	1.000	1.000
391	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOC(3), FBP1(2), FBP2(1), FUK(1), GMDS(1), GMPPB(3), HK1(2), HK2(4), HK3(4), KHK(1), LHPP(1), MPI(1), MTMR2(4), MTMR6(1), PFKFB1(2), PFKFB4(1), PFKL(2), PFKM(3), PFKP(3), PGM2(3), PMM1(1), RDH12(1), TSTA3(5)	27168496	50	30	50	17	17	4	8	12	9	0	0.267	1.000	1.000
392	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), AOX1(2), DBH(5), FAH(1), GOT1(2), GOT2(1), HGD(1), HPD(2), MAOA(2), MAOB(2), PNMT(1), TPO(5), TYR(2)	23251996	41	36	41	13	14	7	3	10	7	0	0.306	1.000	1.000
393	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(3), GHR(1), GRB2(1), HRAS(4), IRS1(3), JAK2(1), MAPK1(1), PIK3CA(16), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RPS6KA1(2), SHC1(3), SOS1(4), STAT5B(2)	24420351	47	35	42	14	15	9	8	10	5	0	0.271	1.000	1.000
394	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CLCA1(1), CLCA2(2), CLCA4(2), CNGA3(1), CNGA4(4), CNGB1(1), GNAL(3), GUCA1A(1), PDE1C(3), PRKACA(2), PRKG1(1), PRKX(2)	22469928	31	27	31	11	10	5	4	5	7	0	0.361	1.000	1.000
395	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), ATP7A(2), ATP7B(2), COX7A1(2), COX7C(1), NDUFA10(2), NDUFA5(1), NDUFB7(1), NDUFS2(2), NDUFV1(1), SDHA(3), SDHB(2), SHMT1(1), UQCRC1(2)	28155279	41	28	41	11	8	12	5	11	5	0	0.167	1.000	1.000
396	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), CASP8(1), DFFA(4), LMNA(4), LMNB2(2), MADD(1), MAP2K4(4), MAP3K1(5), MAP3K7(2), PAK1(1), PAK2(2), PRKDC(11), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(1), TRAF2(5)	28392344	51	32	51	14	18	12	3	10	7	1	0.215	1.000	1.000
397	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CD3D(1), FYN(1), GRB2(1), HRAS(4), MAP2K4(4), MAP3K1(5), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PIK3CA(16), PIK3R1(2), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), PTPN7(4), RAC1(1), RAF1(1), RASA1(1), RELA(3), SHC1(3), SOS1(4), SYT1(1), VAV1(3), ZAP70(6)	35205457	79	49	74	22	26	14	11	19	9	0	0.116	1.000	1.000
398	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH5A1(1), ALDH7A1(2), DDHD1(5), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HADH(3), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), ILVBL(3), L2HGDH(1), OXCT1(5), PDHA1(1), PDHA2(4), RDH12(1)	29827275	62	46	60	16	21	10	7	14	10	0	0.0789	1.000	1.000
399	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(3), BCR(2), GRB2(1), HRAS(4), LYN(2), MAP3K1(5), MAPK1(1), MAPK8IP3(4), PAPPA(3), RAC1(1), RPS6KA1(2), SHC1(3), SOS1(4), SYK(2), VAV1(3), VAV2(3), VAV3(4)	23509829	47	35	45	17	17	7	8	9	6	0	0.400	1.000	1.000
400	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(3), AKT2(1), AKT3(1), BRD4(3), CBL(1), CDKN2A(1), GRB2(1), GSK3A(3), GSK3B(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS2(2), IRS4(3), LNPEP(1), MAPK1(1), PARD3(3), PDK1(2), PIK3CA(16), PIK3CD(5), PIK3R1(2), PTEN(17), PTPN1(2), RAF1(1), RPS6KA1(2), RPS6KA2(2), SHC1(3), SORBS1(3), SOS1(4), SOS2(1), YWHAB(1), YWHAQ(2), YWHAZ(1)	43878352	94	69	90	22	23	12	7	23	29	0	0.134	1.000	1.000
401	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(1), AKT3(1), BRAF(8), CAB39(1), DDIT4(2), EIF4B(2), FIGF(1), HIF1A(2), MAPK1(1), PDPK1(1), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRKAA2(5), RICTOR(1), RPS6(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1), RPS6KB2(2), STK11(1), TSC1(2), TSC2(7), ULK1(1), ULK2(1), ULK3(2), VEGFA(2)	39006359	93	63	88	27	29	17	15	22	10	0	0.156	1.000	1.000
402	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC2(4), ANAPC4(1), ANAPC5(3), ANAPC7(1), BTRC(3), CDC16(1), CDC20(2), CDC23(3), CDC27(2), CUL1(2), CUL2(4), CUL3(5), FBXW11(2), FZR1(4), ITCH(2), SMURF1(1), SMURF2(1), TCEB2(1), UBA1(2), UBE2C(1), VHL(3), WWP1(3), WWP2(1)	29561326	56	35	55	12	10	9	12	14	11	0	0.0685	1.000	1.000
403	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), EPX(4), ESCO1(5), ESCO2(1), GOT1(2), GOT2(1), HPD(2), LPO(2), MAOA(2), MAOB(2), MPO(3), NAT6(1), SH3GLB1(1), TPO(5)	25108403	39	31	39	13	12	6	3	12	6	0	0.537	1.000	1.000
404	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(1), AKT3(1), ARHGEF11(2), DLG4(3), GNA13(2), LPA(5), MAP2K4(4), MAP3K1(5), MAP3K5(2), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PDK1(2), PHKA2(2), PI3(1), PIK3CB(3), PLD1(3), PLD2(2), PTK2(3), RDX(1), ROCK1(5), ROCK2(1), SERPINA4(1), TBXA2R(5)	36201850	64	42	62	17	18	13	5	15	13	0	0.125	1.000	1.000
405	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(8), CREB1(1), EEF2K(5), EIF4E(1), GRB2(1), MAP3K8(1), MAPK1(1), MOS(1), NFKB1(3), RAP1A(1), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1)	21733634	35	24	34	11	12	7	4	8	4	0	0.302	1.000	1.000
406	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(7), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ECHS1(1), EHHADH(5), LDHB(1), LDHC(1), MUT(3), SDS(1), SUCLA2(1)	24448002	41	27	40	12	11	5	7	11	6	1	0.335	1.000	1.000
407	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), FUCA1(1), FUCA2(1), GALNS(4), GLB1(2), HEXB(2), HGSNAT(1), HPSE(3), HYAL2(2), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2), SPAM1(3)	25214885	43	27	43	14	22	6	1	7	7	0	0.302	1.000	1.000
408	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(2), ASAH1(1), B4GALT6(3), CERK(1), DEGS1(1), DEGS2(2), ENPP7(3), GAL3ST1(2), GALC(1), GLB1(2), LCT(6), NEU1(1), NEU2(2), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(1), SMPD2(2), SMPD3(1), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC1(1), SPTLC2(1)	26097497	41	24	41	13	22	5	4	5	5	0	0.158	1.000	1.000
409	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), CHIT1(1), CMAS(1), CTBS(1), CYB5R1(1), GFPT2(2), GNE(1), GNPDA1(1), GNPNAT1(1), HEXB(2), HK1(2), HK2(4), HK3(4), LHPP(1), MTMR2(4), MTMR6(1), NAGK(1), NANS(1), PGM3(1), UAP1(1)	21093853	32	17	32	10	9	6	3	9	5	0	0.400	1.000	1.000
410	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), CRK(1), DOCK1(4), GAB1(1), GRB2(1), HGF(3), HRAS(4), ITGA1(2), MAP4K1(2), MAPK1(1), MET(4), PAK1(1), PIK3CA(16), PIK3R1(2), PTEN(17), PTK2(3), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(1), SOS1(4), STAT3(6)	32392444	78	61	73	22	17	10	14	18	19	0	0.303	1.000	1.000
411	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(1), IPMK(1), ITPK1(1), ITPKB(2), OCRL(3), PI4KA(4), PI4KB(2), PIK3C3(1), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), PTEN(17), SYNJ1(3), SYNJ2(3)	54710006	112	84	109	28	29	18	13	30	22	0	0.0533	1.000	1.000
412	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), AOX1(2), BCAT1(1), BCKDHA(1), ECHS1(1), EHHADH(5), HADHB(1), HMGCL(1), IVD(2), MCCC1(1), MUT(3), OXCT1(5), SDS(1)	26574738	49	35	47	16	14	7	8	12	8	0	0.409	1.000	1.000
413	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4), F10(3), F11(4), F12(1), F2(2), F2R(2), F5(5), F8(1), FGA(5), FGB(2), FGG(1), KLKB1(2), PROC(3), PROS1(3), SERPINC1(2), SERPING1(2)	32528253	56	43	56	21	19	10	2	16	9	0	0.642	1.000	1.000
414	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(2), ESR1(2), NR1D1(3), NR1D2(2), NR1H3(1), NR1I2(2), NR1I3(2), NR2E1(1), NR2F1(1), NR2F2(1), NR4A1(1), NR4A2(2), NR5A2(1), PGR(2), PPARA(2), PPARD(4), PPARG(1), RARA(1), RARB(3), RARG(1), ROR1(1), RORA(1), RXRA(2), RXRB(2), RXRG(2), THRA(6), VDR(2)	30663004	54	37	53	13	27	8	6	8	5	0	0.0424	1.000	1.000
415	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(1), GRB2(1), HRAS(4), MAP2K3(1), MAP2K4(4), MAP3K1(5), MAPK1(1), PAK1(1), PLCG1(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYT1(1)	20926316	34	24	32	12	14	5	5	5	5	0	0.426	1.000	1.000
416	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), IKBKB(1), IRAK1(1), LY96(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP3K7(2), NFKB1(3), PPARA(2), RELA(3), TIRAP(1), TLR10(1), TLR2(2), TLR4(2), TLR7(3), TLR9(1), TRAF6(2)	26685518	38	21	37	13	15	8	2	9	4	0	0.295	1.000	1.000
417	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ASAH1(1), BRAF(8), CREB1(1), CREBBP(8), DAG1(2), EGR1(3), EGR3(1), FRS2(1), MAP1B(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK8IP3(4), NTRK1(9), OPN1LW(1), PIK3C2G(1), PIK3CA(16), PIK3CD(5), PIK3R1(2), PTPN11(1), SHC1(3), TERF2IP(1)	37562650	82	59	77	23	30	13	6	22	11	0	0.132	1.000	1.000
418	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(2), AASDHPPT(1), AASS(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), BBOX1(2), DOT1L(4), ECHS1(1), EHHADH(5), EHMT1(1), EHMT2(3), GCDH(1), PLOD1(2), PLOD3(3), SDS(1), SHMT1(1), SHMT2(1)	27228611	48	36	47	14	14	6	7	11	10	0	0.249	1.000	1.000
419	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(1), CYP4F2(2), CYP4F3(2), EPX(4), LPO(2), MPO(3), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2), TPO(5)	20464935	43	29	43	15	17	8	1	12	5	0	0.336	1.000	1.000
420	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CD4(1), CD8A(1), CD8B(2), CIITA(3), CREB1(1), CTSS(1), HLA-A(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), HSP90AA1(3), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), KIR3DL1(2), KLRC1(1), LGMN(1), NFYA(1), NFYC(3), PDIA3(1), PSME1(1), RFX5(1), RFXAP(1), TAP1(3), TAP2(1)	34126564	50	34	50	13	16	8	7	10	9	0	0.104	1.000	1.000
421	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AKT1(3), CALM1(1), CALR(1), CAMK1(3), CAMK1G(2), CAMK4(4), CREBBP(8), F2(2), GATA4(1), GSK3B(1), HRAS(4), MAPK1(1), MEF2C(3), MYH2(7), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NPPA(1), PIK3CA(16), PIK3R1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RAF1(1), SYT1(1)	37496752	81	51	75	27	24	13	11	24	9	0	0.347	1.000	1.000
422	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), ARSD(1), ARSE(2), CARM1(2), CYP11B1(1), CYP11B2(2), CYP19A1(2), HEMK1(1), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD17B7(2), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), STS(1), SULT1E1(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3)	37005051	62	45	61	17	12	11	8	20	11	0	0.200	1.000	1.000
423	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(2), ACAA2(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ALDH7A1(2), AOX1(2), BCAT1(1), BCAT2(1), BCKDHA(1), DBT(1), DLD(2), ECHS1(1), EHHADH(5), HADH(3), HADHB(1), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), IVD(2), MCCC1(1), MUT(3), OXCT1(5)	31705200	55	40	54	17	17	10	6	13	9	0	0.304	1.000	1.000
424	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(2), ALAS1(3), ALAS2(1), AMT(1), AOC2(3), AOC3(1), BHMT(2), CBS(1), CHDH(4), CTH(2), DAO(1), DLD(2), DMGDH(1), GARS(1), GCAT(1), GLDC(3), MAOA(2), MAOB(2), PHGDH(1), PIPOX(2), PISD(1), PSAT1(1), RDH12(1), SARDH(6), SARS(2), SDS(1), SHMT1(1), SHMT2(1), TARS(3), TARS2(3)	31223027	57	34	57	17	21	13	0	11	11	1	0.264	1.000	1.000
425	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CARM1(2), CREBBP(8), EP300(7), ERCC3(1), ESR1(2), GRIP1(5), GTF2E1(1), HDAC1(1), HDAC2(1), HDAC3(2), HDAC4(3), HDAC5(4), HDAC6(4), MEF2C(3), NCOR2(7), NRIP1(4), PELP1(2), POLR2A(6)	33447832	64	37	64	23	19	14	9	12	10	0	0.362	1.000	1.000
426	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(1), AKT3(1), GRB2(1), GSK3A(3), GSK3B(1), IL4R(3), IRS1(3), IRS2(2), JAK1(6), JAK3(1), MAP4K1(2), MAPK1(1), PDK1(2), PIK3CA(16), PIK3CD(5), PIK3R1(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(4), SOS2(1), STAT6(3)	26906844	68	49	64	23	19	11	6	18	14	0	0.471	1.000	1.000
427	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(6), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(2), G6PC(1), GAA(1), GANAB(3), GBE1(2), GCK(4), GYS1(4), HK1(2), HK2(4), HK3(4), MGAM(4), PGM3(1), PYGB(4), PYGL(4), PYGM(1), RNPC3(1), SI(6), UGDH(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1)	41985061	74	45	73	18	20	13	11	16	14	0	0.0897	1.000	1.000
428	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), CDKN2A(1), DAPP1(1), GAB1(1), ITPR1(4), ITPR2(8), ITPR3(6), LYN(2), PDK1(2), PIK3CA(16), PITX2(3), PLCG2(3), PPP1R13B(3), PREX1(1), PTEN(17), PTPRC(8), RPS6KA1(2), RPS6KA2(2), SAG(2), SYK(2), TEC(1), VAV1(3)	40622870	96	72	92	28	18	16	10	30	22	0	0.364	1.000	1.000
429	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(2), CARS(4), CARS2(2), DARS2(1), EARS2(1), EPRS(4), FARS2(2), FARSB(2), GARS(1), HARS(1), IARS(2), IARS2(1), KARS(2), LARS(3), LARS2(2), MARS2(1), NARS2(1), PARS2(3), QARS(1), RARS2(1), SARS(2), TARS(3), TARS2(3), VARS(4), VARS2(4), WARS(1), WARS2(2), YARS(3), YARS2(3)	40001155	63	40	63	14	25	11	6	14	7	0	0.0812	1.000	1.000
430	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(2), ALAS1(3), ALAS2(1), AMT(1), AOC2(3), AOC3(1), BHMT(2), CBS(1), CHDH(4), CPT1B(2), CTH(2), DAO(1), DLD(2), DMGDH(1), GARS(1), GCAT(1), GLDC(3), MAOA(2), MAOB(2), PISD(1), PLCB2(1), PLCG1(1), PLCG2(3), SARDH(6), SARS(2), SHMT1(1), SHMT2(1), TARS(3)	30685068	55	35	55	16	17	10	2	13	12	1	0.293	1.000	1.000
431	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(7), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), DLAT(1), DLD(2), HAGH(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(1), ME3(1), PC(2), PDHA1(1), PDHA2(4), PKLR(1)	27220442	43	28	41	10	9	8	7	11	7	1	0.108	1.000	1.000
432	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), GK(1), GLB1(2), LCT(6), LIPC(1), LIPG(5), LPL(1), PNLIP(4), PNLIPRP1(1), PPAP2A(1), PPAP2B(1)	35279292	65	43	64	24	22	8	7	16	12	0	0.417	1.000	1.000
433	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BCL2A1(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), CD40(1), CD40LG(1), DAXX(2), DFFA(4), FAS(1), FASLG(1), IKBKE(1), MCL1(1), NFKB1(3), NTRK1(9), PTPN13(1), RIPK1(1), TFG(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF2(5), TRAF6(2)	31959497	46	27	46	10	18	13	2	8	5	0	0.0394	1.000	1.000
434	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(2), B4GALT2(2), FBP2(1), G6PC(1), GAA(1), GALK1(1), GALK2(1), GALT(1), GANAB(3), GCK(4), GLB1(2), HK1(2), HK2(4), HK3(4), LCT(6), MGAM(4), PFKM(3), PFKP(3), PGM3(1)	23846052	46	26	46	17	24	5	3	9	5	0	0.339	1.000	1.000
435	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(3), ATP8A1(1), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CXCR6(1), EDNRA(1), FPR1(3), FSHR(2), GALT(1), GHSR(1), GNRHR(4), GRPR(1), LHCGR(1), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), TACR1(2), TACR2(1), TACR3(2), TRHR(1), TSHR(1)	38530637	91	58	90	27	39	15	4	26	7	0	0.0446	1.000	1.000
436	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(2), EEF1A2(2), EEF1G(1), EEF2(2), EEF2K(5), EIF2AK3(4), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF4A1(1), EIF4E(1), EIF4G1(4), EIF4G3(6), EIF5(2), EIF5A(2), EIF5B(1), ETF1(2), PABPC3(1), SLC35A4(1)	32254089	42	31	42	14	12	3	4	12	11	0	0.510	1.000	1.000
437	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(1), AKT3(1), ASAH1(1), BRAF(8), DAG1(2), DRD2(1), EGFR(3), EPHB2(4), GRB2(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(3), PITX2(3), PLCB1(3), PLCB2(1), PLCB4(8), RAF1(1), SHC1(3), SOS1(4), SOS2(1), STAT3(6), TERF2IP(1)	43074012	83	63	81	24	20	16	6	29	12	0	0.246	1.000	1.000
438	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK2(1), CLK3(3), COL2A1(1), CPSF1(1), CPSF2(1), CSTF2T(5), CSTF3(3), DDX1(1), DHX15(3), DHX16(2), DHX38(3), DHX8(2), DHX9(1), DICER1(1), METTL3(2), NONO(2), NXF1(1), PHF5A(1), POLR2A(6), PPM1G(2), PRPF3(1), PRPF4(2), PRPF4B(3), PRPF8(5), PSKH1(2), PTBP1(6), RBM17(1), RBM5(4), RNGTT(1), RNMT(4), SF3A1(3), SF3A2(2), SF3A3(1), SF3B1(4), SF3B4(1), SF3B5(1), SNRPA1(2), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPG(1), SNRPN(2), SPOP(58), SRPK1(1), SRRM1(1), SUPT5H(3), U2AF1(1), U2AF2(1)	77625375	157	111	118	28	25	19	27	62	24	0	0.00398	1.000	1.000
439	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(2), ACOX1(2), ACOX2(2), ACOX3(1), ACSL1(3), ACSL5(1), ACSL6(3), ADIPOQ(1), APOA5(1), AQP7(2), CD36(1), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), CYP4A11(1), CYP4A22(2), CYP7A1(1), CYP8B1(1), DBI(1), EHHADH(5), FABP2(1), FABP4(1), FABP6(2), FADS2(1), GK(1), HMGCS2(1), ILK(1), LPL(1), ME1(3), NR1H3(1), PCK2(2), PDPK1(1), PLTP(1), PPARA(2), PPARD(4), PPARG(1), RXRA(2), RXRB(2), RXRG(2), SCD(2), SCP2(3), SLC27A1(3), SLC27A4(2), SLC27A5(2), SLC27A6(2), SORBS1(3), UBC(1), UCP1(1)	48151641	89	53	87	21	32	15	9	16	17	0	0.0257	1.000	1.000
440	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(5), ANAPC1(4), ANAPC2(4), ANAPC4(1), ANAPC5(3), ANAPC7(1), ATM(22), ATR(3), BUB1(2), BUB1B(3), BUB3(1), CCNA1(1), CCNB2(1), CCND3(1), CCNE2(1), CCNH(1), CDC14B(2), CDC16(1), CDC20(2), CDC23(3), CDC25A(4), CDC25B(5), CDC27(2), CDC6(1), CDC7(2), CDK7(2), CDKN1A(2), CDKN1B(6), CDKN2A(1), CREBBP(8), CUL1(2), DBF4(1), E2F1(3), E2F3(1), EP300(7), ESPL1(3), FZR1(4), GSK3B(1), HDAC1(1), HDAC2(1), MAD1L1(4), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), PCNA(2), PLK1(1), PRKDC(11), PTTG1(1), RB1(3), RBL1(2), RBL2(2), SMAD2(2), SMAD3(1), SMAD4(7), SMC1A(1), SMC1B(1), TFDP1(2), TGFB2(2), TP53(59), WEE1(1), YWHAB(1), YWHAQ(2), YWHAZ(1)	99940138	242	147	227	41	64	37	36	49	54	2	1.55e-05	1.000	1.000
441	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(3), AKT2(1), AKT3(1), CDKN1B(6), CDKN2A(1), CREB1(1), EBP(1), ERBB4(4), GAB1(1), GRB2(1), GSK3A(3), GSK3B(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS2(2), IRS4(3), MET(4), MYC(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PARD3(3), PDK1(2), PIK3CA(16), PIK3CD(5), PPP1R13B(3), PREX1(1), PTEN(17), PTK2(3), PTPN1(2), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1), TSC1(2), TSC2(7), YWHAB(1), YWHAQ(2), YWHAZ(1)	56955982	126	82	122	29	34	16	8	30	38	0	0.0534	1.000	1.000
442	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), GOT1(2), GOT2(1), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), MDH1(1), PC(2), PDHA1(1), PDHA2(4), PDHX(1), PFKL(2), PFKM(3), PFKP(3), PGAM2(1), PGK2(2), PKLR(1)	31271077	56	28	55	12	21	10	7	8	10	0	0.00893	1.000	1.000
443	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(7), ACACB(3), ACAT1(2), ACAT2(1), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ALDH7A1(2), ECHS1(1), EHHADH(5), HIBCH(1), LDHAL6A(1), LDHB(1), LDHC(1), MUT(3), SUCLA2(1)	29250501	40	29	40	14	10	5	6	14	4	1	0.549	1.000	1.000
444	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(1), ATP5A1(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G3(1), ATP5J(1), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(2), COX4I2(1), COX7A1(2), COX7C(1), CYC1(1), LHPP(1), NDUFA10(2), NDUFA12(1), NDUFA13(2), NDUFA5(1), NDUFA7(1), NDUFA9(1), NDUFB10(2), NDUFB7(1), NDUFB9(1), NDUFS2(2), NDUFS3(2), NDUFV1(1), SDHA(3), SDHB(2), SDHC(2), TCIRG1(1), UQCRC1(2)	41015058	68	43	68	17	16	14	11	16	11	0	0.0738	1.000	1.000
445	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT1(2), B4GALT2(2), G6PC(1), G6PC2(1), GAA(1), GALK1(1), GALK2(1), GALT(1), GANC(3), GCK(4), GLB1(2), HK1(2), HK2(4), HK3(4), LCT(6), MGAM(4), PFKL(2), PFKM(3), PFKP(3), PGM3(1), RDH12(1), UGP2(1)	28305603	50	31	50	19	25	4	4	11	6	0	0.359	1.000	1.000
446	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(3), PGM3(1), PKLR(1)	35983892	67	37	65	16	23	10	9	14	11	0	0.0267	1.000	1.000
447	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(3), PGM3(1), PKLR(1)	35983892	67	37	65	16	23	10	9	14	11	0	0.0267	1.000	1.000
448	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AKR1A1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), DAK(1), DGAT1(1), DGAT2(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), GK(1), GLB1(2), GPAM(2), LCT(6), LIPC(1), LIPG(5), LPL(1), MGLL(1), PNLIP(4), PNLIPRP1(1), PPAP2A(1), PPAP2B(1)	43027161	76	51	76	27	22	10	7	21	16	0	0.423	1.000	1.000
449	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(7), ACACB(3), ACAT1(2), ACAT2(1), ACOT12(2), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), DLAT(1), DLD(2), HAGH(1), LDHAL6A(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(1), ME3(1), PC(2), PCK2(2), PDHA1(1), PDHA2(4), PKLR(1)	34419352	49	34	48	13	10	9	8	14	7	1	0.144	1.000	1.000
450	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(9), CANT1(3), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), ENTPD1(1), NME1(1), NT5E(1), NT5M(1), POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1), RRM2(1), TXNRD1(4), TYMS(1), UCK2(3), UMPS(3), UPP1(2)	42149313	74	45	72	25	23	15	13	12	11	0	0.334	1.000	1.000
451	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), AOX1(2), CARM1(2), DBH(5), ECH1(1), ESCO1(5), ESCO2(1), FAH(1), GOT1(2), GOT2(1), HEMK1(1), HGD(1), HPD(2), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), NAT6(1), PNMT(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), SH3GLB1(1), TPO(5), TYR(2), TYRP1(1)	43728130	63	48	63	23	18	9	7	16	13	0	0.548	1.000	1.000
452	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), AKT1(3), AKT2(1), AKT3(1), ARHGAP5(4), BCAR1(3), BIRC2(1), BRAF(8), CAPN2(2), CAV1(1), CAV3(1), CCND3(1), CHAD(1), COL11A1(16), COL11A2(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), COMP(2), CRK(1), CTNNB1(13), DIAPH1(2), DOCK1(4), EGF(3), EGFR(3), ERBB2(6), FARP2(3), FIGF(1), FLNA(1), FLNB(6), FLNC(8), FLT1(5), FN1(5), FYN(1), GRB2(1), GSK3B(1), HGF(3), HRAS(4), IGF1R(4), ILK(1), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(3), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), KDR(7), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), MAPK1(1), MET(4), MYL5(1), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PARVB(1), PARVG(3), PDGFA(2), PDGFB(1), PDGFC(1), PDGFD(3), PDGFRA(3), PDGFRB(1), PDPK1(1), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PRKCA(2), PRKCG(1), PTEN(17), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RAP1A(1), RAPGEF1(4), RELN(10), RHOA(2), ROCK1(5), ROCK2(1), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TLN1(4), TLN2(5), TNC(4), TNN(5), TNR(2), TNXB(12), VAV1(3), VAV2(3), VAV3(4), VCL(1), VEGFA(2), VTN(1), VWF(6)	272350869	526	251	512	170	162	96	46	135	85	2	0.0170	1.000	1.000
453	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(2), ACVR1C(1), AKT1(3), AKT2(1), AKT3(1), ARRB1(1), ATF2(3), ATF4(1), BDNF(2), BRAF(8), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1F(2), CACNA1G(4), CACNA1H(3), CACNA1I(2), CACNA1S(4), CACNA2D1(2), CACNA2D2(3), CACNA2D3(1), CACNA2D4(2), CACNB1(3), CACNB2(3), CACNB4(1), CACNG1(1), CACNG3(1), CACNG4(1), CACNG5(1), CACNG7(4), CACNG8(1), CD14(2), CDC25B(5), CRK(1), DAXX(2), DUSP1(1), DUSP14(1), DUSP16(1), DUSP7(1), DUSP8(3), ECSIT(2), EGF(3), EGFR(3), FAS(1), FASLG(1), FGF10(2), FGF11(1), FGF16(2), FGF20(1), FGF21(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(3), FGFR3(2), FLNA(1), FLNB(6), FLNC(8), GRB2(1), HRAS(4), IKBKB(1), IL1A(1), IL1R2(1), JUND(2), KRAS(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K8(1), MAP4K1(2), MAP4K2(1), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK13(1), MAPK8IP3(4), MAPKAPK3(1), MAPKAPK5(1), MEF2C(3), MOS(1), MRAS(2), MYC(1), NF1(4), NFATC2(2), NFATC4(1), NFKB1(3), NLK(1), NR4A1(1), NTF3(2), NTRK1(9), PAK1(1), PAK2(2), PDGFA(2), PDGFB(1), PDGFRA(3), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(3), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP5C(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), PTPN5(3), PTPN7(4), PTPRR(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RAP1A(1), RAPGEF2(2), RASA1(1), RASGRF1(3), RASGRF2(3), RASGRP2(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), RPS6KA5(3), RPS6KA6(1), RRAS2(2), SOS1(4), SOS2(1), STK3(1), STK4(3), TAOK1(3), TAOK2(3), TAOK3(2), TGFB2(2), TGFBR1(2), TNF(1), TNFRSF1A(1), TP53(59), TRAF2(5), TRAF6(2)	209015110	422	220	403	144	144	64	43	90	79	2	0.141	1.000	1.000
454	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADORA1(3), ADORA2A(2), ADORA3(3), ADRA1A(1), ADRA1B(2), ADRA2A(2), ADRA2B(2), ADRA2C(2), ADRB1(1), AGTR1(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CALCR(4), CALCRL(1), CCKAR(2), CCKBR(2), CGA(1), CHRM2(2), CHRM3(1), CHRM4(3), CNR1(5), CNR2(1), CRHR2(2), CTSG(2), CYSLTR1(2), CYSLTR2(1), DRD2(1), DRD3(2), DRD4(1), DRD5(1), EDNRA(1), F2(2), F2R(2), F2RL1(1), FPR1(3), FSHR(2), GABBR1(1), GABBR2(3), GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), GABRB1(6), GABRB2(3), GABRB3(1), GABRD(2), GABRE(4), GABRG1(5), GABRG2(1), GABRP(2), GABRQ(1), GABRR1(2), GABRR2(3), GH1(3), GH2(1), GHR(1), GHRHR(1), GHSR(1), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(2), GLRA2(3), GNRHR(4), GPR156(2), GPR35(1), GPR50(4), GPR63(2), GPR83(2), GRIA1(12), GRIA2(5), GRIA3(1), GRIA4(4), GRID1(4), GRID2(6), GRIK1(5), GRIK2(1), GRIK3(6), GRIK4(3), GRIK5(1), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), GRIN3A(3), GRIN3B(1), GRM1(9), GRM2(2), GRM3(4), GRM4(2), GRM5(5), GRM6(3), GRM7(2), GRM8(2), GRPR(1), GZMA(1), HCRTR2(5), HRH1(1), HRH2(1), HRH4(2), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), LEPR(2), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(2), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), P2RX1(2), P2RX4(1), P2RX5(2), P2RY1(1), P2RY10(1), P2RY11(2), P2RY14(2), P2RY2(2), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PRL(1), PRLR(1), PRSS1(2), PTGER2(2), PTGER4(1), PTGIR(3), PTH2R(1), RXFP1(2), RXFP2(1), SCTR(3), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), SSTR5(2), TAAR2(1), TAAR5(1), TAAR6(3), TAAR8(3), TACR1(2), TACR2(1), TACR3(2), TBXA2R(5), THRA(6), TRHR(1), TRPV1(1), TSHR(1)	163340010	405	218	398	129	189	56	27	93	40	0	0.000726	1.000	1.000
455	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(1), ACTN1(1), ACTN2(2), ACTN4(3), APC(10), APC2(3), ARAF(1), ARHGEF1(5), ARHGEF12(1), ARHGEF4(1), ARHGEF6(1), ARHGEF7(1), ARPC5(1), ARPC5L(1), BAIAP2(1), BCAR1(3), BDKRB1(3), BDKRB2(2), BRAF(8), CD14(2), CFL1(1), CHRM2(2), CHRM3(1), CHRM4(3), CRK(1), CYFIP1(4), CYFIP2(6), DIAPH1(2), DIAPH3(2), DOCK1(4), EGF(3), EGFR(3), F2(2), F2R(2), FGD1(2), FGD3(2), FGF10(2), FGF11(1), FGF16(2), FGF20(1), FGF21(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(3), FGFR3(2), FN1(5), GIT1(1), GNA13(2), GSN(6), HRAS(4), IQGAP1(3), IQGAP2(2), IQGAP3(2), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(5), ITGAE(1), ITGAL(5), ITGAM(3), ITGAV(3), ITGAX(3), ITGB2(2), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), KRAS(2), LIMK1(2), LIMK2(4), MAPK1(1), MOS(1), MRAS(2), MSN(1), MYH10(7), MYH14(3), MYH9(6), MYL5(1), MYLK(4), MYLK2(4), NCKAP1(1), NCKAP1L(6), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDGFA(2), PDGFB(1), PDGFRA(3), PDGFRB(1), PFN1(1), PFN2(3), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PPP1R12B(1), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RDX(1), RHOA(2), ROCK1(5), ROCK2(1), RRAS2(2), SCIN(1), SLC9A1(2), SOS1(4), SOS2(1), SSH1(3), SSH2(8), SSH3(3), TIAM1(5), TIAM2(6), VAV1(3), VAV2(3), VAV3(4), VCL(1), WAS(2), WASF1(2), WASF2(2)	202570727	398	214	387	120	123	61	41	110	62	1	0.0171	1.000	1.000
456	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY8(7), ADCY9(5), ADORA2A(2), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), AGTR1(3), ATP2A1(5), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(7), ATP2B3(7), ATP2B4(5), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1F(2), CACNA1G(4), CACNA1H(3), CACNA1I(2), CACNA1S(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CAMK4(4), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CHRM3(1), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EGFR(3), ERBB2(6), ERBB3(5), ERBB4(4), F2R(2), GNA11(1), GNA14(1), GNAL(3), GNAS(2), GRIN1(3), GRIN2A(11), GRIN2C(3), GRM1(9), GRM5(5), GRPR(1), HRH1(1), HRH2(1), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), LHCGR(1), MYLK(4), MYLK2(4), NOS1(3), NOS3(2), NTSR1(3), P2RX1(2), P2RX4(1), P2RX5(2), PDE1B(1), PDE1C(3), PDGFRA(3), PDGFRB(1), PHKA1(2), PHKA2(2), PHKB(3), PHKG2(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), PLN(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RYR1(20), RYR2(17), RYR3(18), SLC25A6(1), SLC8A1(7), SLC8A2(1), SLC8A3(4), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(5), TRHR(1), VDAC1(1)	196886616	402	212	400	160	167	57	24	95	59	0	0.365	1.000	1.000
457	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(10), APC2(3), AXIN1(1), AXIN2(5), BTRC(3), CACYBP(1), CAMK2A(1), CAMK2D(2), CCND3(1), CHD8(3), CREBBP(8), CSNK1A1L(1), CSNK1E(3), CSNK2A2(1), CSNK2B(1), CTNNB1(13), CUL1(2), DAAM1(4), DAAM2(4), DKK1(3), DKK2(2), DVL1(1), DVL2(3), DVL3(1), EP300(7), FBXW11(2), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GSK3B(1), LEF1(2), LRP5(4), LRP6(4), MAP3K7(2), MYC(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NKD2(1), NLK(1), PLCB1(3), PLCB2(1), PLCB4(8), PPARD(4), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRICKLE1(2), PRICKLE2(7), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAC1(1), RAC2(1), RAC3(2), RHOA(2), ROCK1(5), ROCK2(1), RUVBL1(1), SFRP2(3), SFRP5(1), SMAD2(2), SMAD3(1), SMAD4(7), SOX17(1), TBL1X(1), TBL1XR1(2), TCF7(1), TCF7L1(1), TCF7L2(2), TP53(59), VANGL2(5), WIF1(2), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2)	119141885	295	175	274	82	87	50	35	63	59	1	0.00722	1.000	1.000
458	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(2), CHAD(1), COL11A1(16), COL11A2(4), COL17A1(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), COMP(2), DSC1(2), DSC3(2), DSG1(1), DSG2(4), DSG4(2), FN1(5), GJA1(1), GJA3(1), GJA4(2), GJA5(3), GJA8(5), GJB2(1), GJB4(2), GJB5(2), GJB6(1), GJC2(2), ITGA6(2), ITGB4(4), KRT1(1), KRT10(1), KRT12(1), KRT13(2), KRT14(1), KRT15(2), KRT16(4), KRT18(1), KRT19(1), KRT2(1), KRT23(2), KRT24(2), KRT25(6), KRT27(4), KRT28(1), KRT3(2), KRT31(4), KRT33A(1), KRT33B(1), KRT36(2), KRT37(2), KRT38(2), KRT39(2), KRT4(3), KRT40(2), KRT5(1), KRT6A(1), KRT6B(2), KRT6C(4), KRT7(3), KRT72(1), KRT73(2), KRT75(2), KRT76(2), KRT77(1), KRT78(5), KRT79(2), KRT81(1), KRT83(1), KRT84(1), KRT85(3), KRT86(1), KRT9(2), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), LMNA(4), LMNB2(2), NES(3), RELN(10), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNC(4), TNN(5), TNR(2), TNXB(12), VIM(1), VTN(1), VWF(6)	182462955	339	170	338	102	145	64	14	66	49	1	0.00127	1.000	1.000
459	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), AKT1(3), AKT2(1), AKT3(1), ASH1L(7), CGN(4), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTNNB1(13), CTTN(1), EPB41L1(2), EPB41L2(4), EPB41L3(15), EXOC3(4), EXOC4(2), GNAI1(2), GNAI2(2), HCLS1(1), HRAS(4), IGSF5(1), INADL(5), JAM2(1), KRAS(2), LLGL1(3), LLGL2(2), MAGI1(2), MAGI2(2), MAGI3(3), MLLT4(5), MPDZ(3), MRAS(2), MYH1(4), MYH10(7), MYH11(7), MYH13(8), MYH14(3), MYH15(7), MYH2(7), MYH3(3), MYH4(9), MYH6(10), MYH7(7), MYH7B(4), MYH8(11), MYH9(6), MYL5(1), PARD3(3), PPM1J(1), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R4(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), PTEN(17), RHOA(2), RRAS2(2), SPTAN1(2), SYMPK(2), TJAP1(2), TJP1(1), TJP2(5), TJP3(2), VAPA(2), YES1(1)	142963943	288	167	281	87	104	42	24	70	48	0	0.0427	1.000	1.000
460	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), ANXA6(2), ARRB1(1), ATP1A4(1), ATP1B2(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(7), ATP2B3(7), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1S(4), CACNB1(3), CALM1(1), CALR(1), CAMK1(3), CAMK2A(1), CAMK2D(2), CAMK4(4), CHRM2(2), CHRM3(1), CHRM4(3), GJA1(1), GJA4(2), GJA5(3), GJB2(1), GJB4(2), GJB5(2), GJB6(1), GNA11(1), GNAI2(2), GNAO1(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(1), GRK6(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNB1(4), KCNJ5(2), MIB1(2), NME7(1), PLN(1), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RGS11(1), RGS16(2), RGS18(1), RGS3(2), RGS6(3), RGS7(1), RGS9(2), RYR1(20), RYR2(17), RYR3(18), SLC8A1(7), SLC8A3(4), USP5(1), YWHAB(1), YWHAQ(2)	137346408	286	157	285	117	133	34	17	63	39	0	0.489	1.000	1.000
461	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(3), CD36(1), CD47(1), CHAD(1), COL11A1(16), COL11A2(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), DAG1(2), FN1(5), FNDC1(6), FNDC3A(2), GP5(4), GP9(1), HMMR(1), HSPG2(12), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(3), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), RELN(10), SDC3(1), SDC4(1), SV2A(3), SV2B(2), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNC(4), TNN(5), TNR(2), TNXB(12), VTN(1), VWF(6)	163982120	292	154	290	89	107	55	16	65	48	1	0.00860	1.000	1.000
462	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(5), ABLIM1(3), ARHGEF12(1), CFL1(1), DCC(6), DPYSL2(2), DPYSL5(1), EFNA2(1), EFNA3(1), EFNA5(2), EFNB2(1), EFNB3(2), EPHA1(5), EPHA2(2), EPHA3(5), EPHA4(4), EPHA5(1), EPHA6(2), EPHA7(2), EPHA8(2), EPHB1(8), EPHB2(4), EPHB3(4), EPHB6(3), FES(3), FYN(1), GNAI1(2), GNAI2(2), GSK3B(1), HRAS(4), KRAS(2), L1CAM(6), LIMK1(2), LIMK2(4), LRRC4C(3), MAPK1(1), MET(4), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NGEF(5), NRP1(2), NTN1(1), NTNG1(3), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PLXNA1(8), PLXNA2(3), PLXNA3(2), PLXNB1(4), PLXNB2(4), PLXNB3(1), PLXNC1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTK2(3), RAC1(1), RAC2(1), RAC3(2), RASA1(1), RGS3(2), RHOA(2), RHOD(2), ROBO1(7), ROBO2(10), ROBO3(2), ROCK1(5), ROCK2(1), SEMA3A(2), SEMA3C(3), SEMA3D(4), SEMA3E(2), SEMA3F(4), SEMA3G(2), SEMA4A(1), SEMA4C(3), SEMA4F(2), SEMA4G(2), SEMA5A(5), SEMA5B(2), SEMA6A(5), SEMA6C(3), SEMA6D(2), SEMA7A(2), SLIT1(2), SLIT2(3), SLIT3(4), SRGAP1(4), SRGAP3(2), UNC5A(1), UNC5B(5), UNC5D(3)	144399405	268	138	264	97	108	35	23	69	33	0	0.277	1.000	1.000
463	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(7), ACACB(3), AKT1(3), AKT2(1), AKT3(1), ARAF(1), BRAF(8), CALM1(1), CALML3(1), CALML6(1), CBL(1), CBLB(1), CBLC(1), CRK(1), EXOC7(1), FASN(5), FBP1(2), FBP2(1), FOXO1(1), G6PC(1), G6PC2(1), GCK(4), GRB2(1), GSK3B(1), GYS1(4), HRAS(4), IKBKB(1), INPP5D(3), IRS1(3), IRS2(2), IRS4(3), KRAS(2), MAPK1(1), PCK2(2), PDE3A(2), PDE3B(3), PDPK1(1), PFKL(2), PFKM(3), PFKP(3), PHKA1(2), PHKA2(2), PHKB(3), PHKG2(2), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PKLR(1), PPARGC1A(4), PPP1CA(1), PPP1R3A(7), PPP1R3B(2), PRKAA2(5), PRKACA(2), PRKAG1(3), PRKAG3(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCI(1), PRKCZ(3), PRKX(2), PTPN1(2), PTPRF(5), PYGB(4), PYGL(4), PYGM(1), RAF1(1), RAPGEF1(4), RPS6(1), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOCS4(2), SORBS1(3), SOS1(4), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(7)	117414981	228	137	219	68	79	35	33	54	26	1	0.0194	1.000	1.000
464	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1B(2), ACVR2A(2), BMP2(2), BMP7(3), BMPR1A(2), BMPR1B(2), BMPR2(3), CCL11(1), CCL15(1), CCL17(1), CCL21(1), CCL28(1), CCL7(1), CCL8(1), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CCR9(1), CD27(1), CD40(1), CD40LG(1), CNTF(1), CSF1(1), CSF1R(5), CSF2RA(3), CSF2RB(1), CSF3R(1), CX3CL1(1), CXCL9(1), CXCR6(1), EDA(1), EGF(3), EGFR(3), EPOR(1), FAS(1), FASLG(1), FLT1(5), FLT3(2), FLT3LG(1), FLT4(4), GH1(3), GH2(1), GHR(1), HGF(3), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(4), IL17RB(1), IL18RAP(2), IL1A(1), IL1R2(1), IL1RAP(2), IL20(1), IL20RA(2), IL21(2), IL21R(2), IL22(1), IL22RA2(1), IL23R(1), IL24(3), IL25(1), IL26(1), IL2RB(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL6ST(7), IL7(2), IL7R(1), IL9(2), INHBA(2), INHBC(2), INHBE(1), KDR(7), KIT(3), LEPR(2), LIFR(4), LTBR(2), MET(4), OSMR(1), PDGFB(1), PDGFC(1), PDGFRA(3), PDGFRB(1), PF4(1), PRL(1), PRLR(1), TGFB2(2), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11B(2), TNFRSF13B(3), TNFRSF18(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(7), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(3), TNFSF11(1), TNFSF12(1), TNFSF14(2), TNFSF15(1), TNFSF8(2), TPO(5), VEGFA(2), XCL1(1), XCR1(2)	130081861	236	132	236	84	61	38	26	67	43	1	0.264	1.000	1.000
465	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(8), CACNA1A(12), GNA11(1), GNA13(2), GNAI1(2), GNAI2(2), GNAO1(1), GNAS(2), GNAZ(3), GRIA1(12), GRIA2(5), GRIA3(1), GRID2(6), GRM1(9), GRM5(5), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), HRAS(4), IGF1R(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), LYN(2), MAPK1(1), NOS1(3), NOS3(2), NPR1(1), NPR2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(1), PLCB4(8), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PRKCA(2), PRKCG(1), PRKG1(1), RAF1(1), RYR1(20)	80820048	182	127	176	50	71	23	14	52	22	0	0.0337	1.000	1.000
466	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(3), ADORA2A(2), ADORA3(3), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(2), ADRB1(1), AGTR1(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CCR9(1), CCRL2(1), CHRM2(2), CHRM3(1), CHRM4(3), CMKLR1(2), CNR1(5), CNR2(1), DRD2(1), DRD3(2), DRD4(1), DRD5(1), EDNRA(1), F2R(2), F2RL1(1), FPR1(3), FSHR(2), GALT(1), GHSR(1), GPR17(2), GPR174(1), GPR35(1), GPR37(2), GPR37L1(3), GPR4(1), GPR50(4), GPR6(1), GPR63(2), GPR83(2), GPR87(3), GRPR(1), HCRTR2(5), HRH1(1), HRH2(1), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1A(1), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(2), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPN1SW(1), OPN3(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), OR12D3(1), OR1Q1(1), OR5V1(1), OR7A5(2), OR8B8(1), P2RY1(1), P2RY10(1), P2RY11(2), P2RY14(2), P2RY2(2), P2RY6(1), PTGER2(2), PTGER4(1), PTGIR(3), RGR(2), RHO(1), RRH(1), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), TBXA2R(5), TRHR(1)	89410440	214	126	212	77	91	36	13	55	19	0	0.0422	1.000	1.000
467	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(2), CADM1(2), CADM3(3), CD2(1), CD226(2), CD276(1), CD28(2), CD34(1), CD4(1), CD40(1), CD40LG(1), CD6(1), CD86(1), CD8A(1), CD8B(2), CDH1(4), CDH15(1), CDH2(2), CDH3(3), CDH4(5), CDH5(5), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CNTN2(1), CNTNAP1(9), CNTNAP2(2), ESAM(1), GLG1(2), HLA-A(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), ICAM1(1), ICAM2(2), ICAM3(1), ITGA4(3), ITGA6(2), ITGA8(3), ITGA9(4), ITGAL(5), ITGAM(3), ITGAV(3), ITGB2(2), ITGB7(1), ITGB8(2), JAM2(1), L1CAM(6), MADCAM1(1), MAG(2), NCAM1(1), NCAM2(3), NEGR1(3), NEO1(4), NFASC(3), NLGN1(1), NLGN2(1), NLGN3(2), NRCAM(4), NRXN1(3), NRXN2(2), NRXN3(8), PDCD1(1), PTPRC(8), PTPRF(5), PTPRM(1), PVRL1(2), PVRL2(2), PVRL3(1), SDC3(1), SDC4(1), SELE(1), SELP(4), SELPLG(2), SIGLEC1(8), SPN(1), VCAM1(2), VCAN(4)	108188392	197	122	193	70	72	35	17	42	31	0	0.181	1.000	1.000
468	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(2), ACTN4(3), ARHGAP5(4), BCAR1(3), CDH5(5), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTNNB1(13), CTNND1(1), CYBB(2), ESAM(1), GNAI1(2), GNAI2(2), ICAM1(1), ITGA4(3), ITGAL(5), ITGAM(3), ITGB2(2), ITK(3), JAM2(1), MAPK12(1), MAPK13(1), MLLT4(5), MMP9(5), MSN(1), MYL5(1), NCF1(1), NCF2(3), NCF4(3), NOX3(5), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCG(1), PTK2(3), PTPN11(1), PXN(1), RAC1(1), RAC2(1), RAP1A(1), RAPGEF3(1), RAPGEF4(3), RASSF5(1), RHOA(2), ROCK1(5), ROCK2(1), SIPA1(5), VAV1(3), VAV2(3), VAV3(4), VCAM1(2), VCL(1)	91167868	187	122	178	60	63	24	24	48	28	0	0.193	1.000	1.000
469	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ARRB1(1), ATF2(3), ATF3(1), ATF4(1), ATF5(1), ATP2A2(1), ATP2A3(1), CALCA(1), CALM1(1), CAMK2A(1), CAMK2D(2), CNN1(1), CORIN(4), DGKZ(3), GBA2(1), GJA1(1), GNB1(1), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(1), GRK6(2), GSTO1(2), GUCY1A3(1), IGFBP1(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL6(1), ITPR1(4), ITPR2(8), ITPR3(6), MAFF(1), MIB1(2), MYLK2(4), NFKB1(3), NOS1(3), NOS3(2), PLCD1(1), PLCG1(1), PLCG2(3), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RAMP1(1), RAMP2(1), RAMP3(1), RGS11(1), RGS16(2), RGS18(1), RGS3(2), RGS6(3), RGS7(1), RGS9(2), RYR1(20), RYR2(17), RYR3(18), SLC8A1(7), SP1(2), TNXB(12), USP5(1), YWHAB(1), YWHAQ(2)	126857847	226	121	226	105	90	36	14	50	36	0	0.872	1.000	1.000
470	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(3), AKT2(1), AKT3(1), CBL(1), CBLB(1), CBLC(1), CCND3(1), CNTF(1), CREBBP(8), CSF2RA(3), CSF2RB(1), CSF3R(1), EP300(7), EPOR(1), GH1(3), GH2(1), GHR(1), GRB2(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL20(1), IL20RA(2), IL21(2), IL21R(2), IL22(1), IL22RA2(1), IL23R(1), IL24(3), IL26(1), IL2RB(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL6ST(7), IL7(2), IL7R(1), IL9(2), JAK1(6), JAK2(1), JAK3(1), LEPR(2), LIFR(4), MYC(1), OSMR(1), PIAS3(2), PIAS4(3), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRL(1), PRLR(1), PTPN11(1), SOCS4(2), SOCS5(2), SOS1(4), SOS2(1), SPRED2(2), SPRY3(1), STAM2(1), STAT1(1), STAT2(2), STAT3(6), STAT4(6), STAT5B(2), STAT6(3), TPO(5), TYK2(2)	107062896	193	119	189	64	44	33	27	50	39	0	0.232	1.000	1.000
471	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALML3(1), CALML6(1), CDS1(3), CDS2(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPP5B(2), INPP5D(3), INPP5E(2), INPPL1(1), ITPK1(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), OCRL(3), PI4KA(4), PI4KB(2), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3C3(1), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), PRKCA(2), PRKCG(1), PTEN(17), SYNJ1(3), SYNJ2(3)	91511640	180	114	177	53	50	32	18	44	36	0	0.115	1.000	1.000
472	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(5), ACTN1(1), ACTR3(1), AKT1(3), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF6(1), ARHGEF7(1), BCAR1(3), BRAF(8), CAV1(1), CDKN2A(1), CRK(1), CSE1L(1), DOCK1(4), EPHB2(4), FYN(1), GRB2(1), GRB7(2), ILK(1), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), MAP2K4(4), MAP2K7(4), MAP3K11(1), MAPK1(1), MAPK8IP3(4), MRAS(2), MYLK(4), MYLK2(4), P4HB(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PIK3CA(16), PIK3CB(3), PKLR(1), PLCG1(1), PLCG2(3), PTEN(17), PTK2(3), RAF1(1), RHO(1), ROCK1(5), ROCK2(1), SHC1(3), SOS1(4), SOS2(1), TERF2IP(1), TLN1(4), TLN2(5), WAS(2)	89924275	183	113	177	54	43	28	19	52	41	0	0.188	1.000	1.000
473	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(2), ADCY8(7), ARAF(1), ATF4(1), BRAF(8), CACNA1C(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CAMK4(4), CREBBP(8), EP300(7), GRIA1(12), GRIA2(5), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), GRM1(9), GRM5(5), HRAS(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAPK1(1), PLCB1(3), PLCB2(1), PLCB4(8), PPP1CA(1), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), RAP1A(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1)	72890232	163	109	157	52	51	22	12	56	22	0	0.244	1.000	1.000
474	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADSL(1), ADSS(1), AK2(1), AK5(1), AK7(2), ALLC(1), AMPD1(4), AMPD2(4), AMPD3(1), APRT(1), ATIC(5), CANT1(3), DGUOK(1), ENPP1(3), ENPP3(2), ENTPD1(1), ENTPD3(2), ENTPD4(2), ENTPD6(2), FHIT(1), GART(1), GMPR(3), GMPR2(1), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), NME1(1), NME7(1), NPR1(1), NPR2(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), PAPSS2(1), PDE10A(5), PDE1C(3), PDE2A(2), PDE3B(3), PDE4A(3), PDE4C(1), PDE5A(1), PDE6D(1), PDE7A(1), PDE8A(5), PDE8B(1), PDE9A(4), PFAS(2), PKLR(1), POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3), PPAT(1), PRIM2(2), PRPS1L1(4), RFC5(1), RRM2(1), XDH(1)	120120753	183	108	181	71	64	41	18	38	22	0	0.422	1.000	1.000
475	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(5), AKT1(3), AKT2(1), AKT3(1), ARAF(1), BRAF(8), CAMK2A(1), CAMK2D(2), CBL(1), CBLB(1), CBLC(1), CDKN1A(2), CDKN1B(6), CRK(1), EGF(3), EGFR(3), ERBB2(6), ERBB3(5), ERBB4(4), GAB1(1), GRB2(1), GSK3B(1), HRAS(4), KRAS(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MYC(1), NRG1(4), NRG2(4), NRG3(3), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCG(1), PTK2(3), RAF1(1), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), STAT5B(2)	75509369	161	105	154	50	48	24	19	40	30	0	0.181	1.000	1.000
476	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADRB1(1), DRD2(1), EGF(3), EGFR(3), GJA1(1), GNA11(1), GNAI1(2), GNAI2(2), GNAS(2), GRB2(1), GRM1(9), GRM5(5), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), HRAS(4), HTR2A(2), HTR2B(2), HTR2C(3), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAPK1(1), NPR1(1), NPR2(1), PDGFA(2), PDGFB(1), PDGFC(1), PDGFD(3), PDGFRA(3), PDGFRB(1), PLCB1(3), PLCB2(1), PLCB4(8), PRKACA(2), PRKCA(2), PRKCG(1), PRKG1(1), PRKX(2), RAF1(1), SOS1(4), SOS2(1), TJP1(1), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2)	97374256	163	105	160	62	59	26	10	49	19	0	0.431	1.000	1.000
477	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(1), BCAR1(3), CAPN1(2), CAPN10(1), CAPN11(5), CAPN2(2), CAPN3(1), CAPN5(1), CAPN6(1), CAPN7(1), CAPNS1(2), CAV1(1), CAV3(1), CRK(1), DOCK1(4), FYN(1), GIT2(2), GRB2(1), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(5), ITGAE(1), ITGAL(5), ITGAM(3), ITGAV(3), ITGAX(3), ITGB2(2), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), MAP2K3(1), MAP2K6(1), MAPK12(1), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PDPK1(1), PIK3R2(3), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAPGEF1(4), RHO(1), ROCK1(5), ROCK2(1), SHC1(3), SHC3(1), SORBS1(3), SOS1(4), TLN1(4), TNS1(6), VAV2(3), VAV3(4), VCL(1)	98316300	173	104	170	52	47	31	13	52	30	0	0.0736	1.000	1.000
478	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDH1(4), CREBBP(8), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTNNB1(13), CTNND1(1), EGFR(3), EP300(7), ERBB2(6), FARP2(3), FER(1), FGFR1(2), FYN(1), IGF1R(4), IQGAP1(3), LEF1(2), LMO7(1), MAP3K7(2), MAPK1(1), MET(4), MLLT4(5), NLK(1), PARD3(3), PTPN1(2), PTPRB(5), PTPRF(5), PTPRJ(1), PTPRM(1), PVRL1(2), PVRL2(2), PVRL3(1), PVRL4(1), RAC1(1), RAC2(1), RAC3(2), RHOA(2), SMAD2(2), SMAD3(1), SMAD4(7), SNAI1(1), SORBS1(3), SSX2IP(1), TCF7(1), TCF7L1(1), TCF7L2(2), TGFBR1(2), TJP1(1), VCL(1), WAS(2), WASF1(2), WASF2(2), WASF3(1), YES1(1)	88203362	157	103	152	44	46	24	20	47	20	0	0.0634	1.000	1.000
479	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(1), BRAF(8), CD247(1), CD48(4), FAS(1), FASLG(1), FYN(1), GRB2(1), HLA-A(1), HLA-G(2), HRAS(4), ICAM1(1), ICAM2(2), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), ITGAL(5), ITGB2(2), KIR3DL1(2), KLRC1(1), KRAS(2), LCP2(2), MAPK1(1), MICB(1), NCR1(1), NCR2(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PAK1(1), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRF1(2), PRKCA(2), PRKCG(1), PTPN11(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), VAV1(3), VAV2(3), VAV3(4), ZAP70(6)	83363048	162	103	155	57	54	20	23	39	26	0	0.370	1.000	1.000
480	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(2), ACTN4(3), DMD(5), MYBPC1(2), MYBPC2(5), MYBPC3(3), MYH3(3), MYH6(10), MYH7(7), MYH8(11), MYL1(1), MYOM1(5), NEB(9), TCAP(2), TNNI1(1), TNNT3(1), TPM1(1), TPM2(1), TPM4(1), TTN(87), VIM(1)	99952471	162	103	161	44	52	27	24	39	18	2	0.0391	1.000	1.000
481	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CREB1(1), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(8), CTNNB1(13), DVL1(1), DVL2(3), DVL3(1), EP300(7), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GNAI1(2), GNAI2(2), GNAO1(1), GNAS(2), GSK3B(1), HRAS(4), KIT(3), KRAS(2), LEF1(2), MAPK1(1), MITF(1), PLCB1(3), PLCB2(1), PLCB4(8), POMC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), TCF7(1), TCF7L1(1), TCF7L2(2), TYR(2), TYRP1(1), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2)	80137388	160	98	155	74	56	30	16	40	18	0	0.726	1.000	1.000
482	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(2), ACVRL1(3), AKT1(3), AURKB(2), BMPR1A(2), BMPR2(3), BUB1(2), CDKL1(1), CDKL2(5), CDS1(3), CDS2(1), CLK1(2), CLK2(1), COL4A3BP(3), CSNK2A2(1), CSNK2B(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPPL1(1), ITPKB(2), MAP3K10(4), MOS(1), NEK1(3), OCRL(3), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3CA(16), PIK3CB(3), PIK3CG(7), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCG1(1), PLCG2(3), PLK3(3), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), STK11(1), TGFBR1(2)	82786298	161	93	157	46	46	30	24	42	19	0	0.0536	1.000	1.000
483	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ATF4(1), CACNA1C(4), CACNA1D(4), CACNA1F(2), CACNA1S(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CGA(1), EGFR(3), GNA11(1), GNAS(2), GNRHR(4), GRB2(1), HRAS(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K3(1), MAP3K4(3), MAPK1(1), MAPK12(1), MAPK13(1), MMP14(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(1), PLCB4(8), PLD1(3), PLD2(2), PRKACA(2), PRKCA(2), PRKX(2), RAF1(1), SOS1(4), SOS2(1)	92824624	145	91	143	56	45	28	8	39	25	0	0.541	1.000	1.000
484	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(2), ACVR1C(1), ACVR2A(2), ACVRL1(3), BMP2(2), BMP4(1), BMP5(4), BMP6(1), BMP7(3), BMP8B(1), BMPR1A(2), BMPR1B(2), BMPR2(3), CHRD(1), COMP(2), CREBBP(8), CUL1(2), DCN(2), EP300(7), FST(1), GDF6(1), GDF7(2), INHBA(2), INHBC(2), INHBE(1), LEFTY1(1), LTBP1(5), MAPK1(1), MYC(1), NODAL(1), PITX2(3), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), RBL1(2), RBL2(2), RHOA(2), ROCK1(5), ROCK2(1), RPS6KB2(2), SMAD2(2), SMAD3(1), SMAD4(7), SMAD6(2), SMAD7(1), SMAD9(1), SMURF1(1), SMURF2(1), SP1(2), TFDP1(2), TGFB2(2), TGFBR1(2), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNF(1), ZFYVE16(3), ZFYVE9(1)	72899279	135	90	132	39	35	25	22	34	19	0	0.0837	1.000	1.000
485	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(1), GAB2(5), GRB2(1), HRAS(4), IL4(1), INPP5D(3), KRAS(2), LCP2(2), LYN(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAPK1(1), MAPK12(1), MAPK13(1), MS4A2(1), PDK1(2), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCE(2), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SOS1(4), SOS2(1), SYK(2), TNF(1), VAV1(3), VAV2(3), VAV3(4)	53134429	124	89	118	36	36	19	17	34	18	0	0.129	1.000	1.000
486	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(1), AKT3(1), CARD11(5), CBL(1), CBLB(1), CBLC(1), CD247(1), CD28(2), CD3D(1), CD4(1), CD40LG(1), CD8A(1), CD8B(2), FYN(1), GRB2(1), HRAS(4), IKBKB(1), IL10(1), IL4(1), ITK(3), KRAS(2), LCP2(2), MAP3K8(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDCD1(1), PDK1(2), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCQ(3), PTPRC(8), RHOA(2), SOS1(4), SOS2(1), TEC(1), TNF(1), VAV1(3), VAV2(3), VAV3(4), ZAP70(6)	74820729	147	88	140	47	45	23	18	40	21	0	0.189	1.000	1.000
487	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR3(1), AKT1(3), AKT2(1), AKT3(1), ANGPTL2(1), ARHGAP1(1), ARHGEF11(2), BTK(1), CFL1(1), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(8), ITPR3(6), LIMK1(2), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDK1(2), PIK3CA(16), PIK3CD(5), PIK3CG(7), PIK3R1(2), PITX2(3), PPP1R13B(3), PTEN(17), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(1), SAG(2), WASF1(2)	51596714	119	88	114	35	30	16	12	32	29	0	0.383	1.000	1.000
488	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADSL(1), ADSS(1), AK2(1), AK5(1), ALLC(1), AMPD1(4), AMPD2(4), AMPD3(1), APRT(1), ATIC(5), ATP5A1(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G3(1), ATP5J(1), CANT1(3), DGUOK(1), ENPP1(3), ENPP3(2), ENTPD1(1), FHIT(1), GART(1), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), NME1(1), NPR1(1), NPR2(1), NT5E(1), NT5M(1), PAPSS2(1), PDE4A(3), PDE4C(1), PDE5A(1), PDE6B(2), PDE6C(1), PDE8A(5), PDE9A(4), PFAS(2), PKLR(1), POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1), PPAT(1), PRPS1L1(4), RRM2(1)	94366604	144	87	142	61	47	29	20	30	18	0	0.775	1.000	1.000
489	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(6), AMY2A(1), AMY2B(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(6), DDX41(4), DDX47(3), DDX50(4), DDX56(2), ENPP1(3), ENPP3(2), ENTPD7(1), EP400(4), ERCC2(3), ERCC3(1), G6PC(1), G6PC2(1), GAA(1), GANC(3), GBE1(2), GCK(4), GYS1(4), HK1(2), HK2(4), HK3(4), MGAM(4), MOV10L1(2), PGM3(1), PYGB(4), PYGL(4), PYGM(1), RAD54B(4), RAD54L(2), RUVBL2(3), SETX(6), SI(6), SKIV2L2(4), SMARCA2(3), SMARCA5(3), UGDH(2), UGP2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3)	91255905	149	86	148	50	37	25	25	40	22	0	0.354	1.000	1.000
490	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), AKAP1(4), AKAP10(1), AKAP11(3), AKAP12(6), AKAP2(1), AKAP3(2), AKAP4(2), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(10), ARHGEF1(5), CALM1(1), GNA11(1), GNA13(2), GNA14(1), GNAI2(2), GNAL(3), GNAO1(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB5(1), GNGT1(1), HRAS(4), ITPR1(4), KRAS(2), PDE1B(1), PDE1C(3), PDE4A(3), PDE4C(1), PDE7A(1), PDE8A(5), PDE8B(1), PPP3CA(2), PPP3CC(2), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), PRKD1(2), PRKD3(1), RHOA(2), SLC9A1(2), USP5(1)	86151886	145	82	142	51	53	20	15	37	20	0	0.337	1.000	1.000
491	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(8), ABCA10(1), ABCA12(5), ABCA13(14), ABCA2(2), ABCA3(3), ABCA4(4), ABCA5(5), ABCA6(1), ABCA7(4), ABCA8(3), ABCA9(5), ABCB1(8), ABCB10(1), ABCB11(3), ABCB4(2), ABCB5(4), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(1), ABCC1(1), ABCC10(3), ABCC11(6), ABCC12(5), ABCC2(1), ABCC3(2), ABCC4(3), ABCC5(4), ABCC6(2), ABCC8(4), ABCC9(3), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(3), ABCG4(3), CFTR(3), TAP1(3), TAP2(1)	86750508	129	79	129	56	43	25	15	21	24	1	0.605	1.000	1.000
492	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(1), AKT3(1), BTK(1), CARD11(5), CD72(1), CD79A(2), CD81(2), CR2(2), GSK3B(1), HRAS(4), IKBKB(1), INPP5D(3), KRAS(2), LYN(2), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAC1(1), RAC2(1), RAC3(2), SYK(2), VAV1(3), VAV2(3), VAV3(4)	54777915	108	78	102	42	31	17	17	27	16	0	0.579	1.000	1.000
493	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), CD81(2), CR2(2), DAG1(2), GRB2(1), GSK3A(3), GSK3B(1), INPP5D(3), ITPR1(4), ITPR2(8), ITPR3(6), LYN(2), MAP4K1(2), MAPK1(1), NFATC1(2), NFATC2(2), PDK1(2), PIK3CA(16), PIK3CD(5), PIK3R1(2), PLCG2(3), PPP1R13B(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTPRC(8), RAF1(1), SHC1(3), SOS1(4), SOS2(1), SYK(2), VAV1(3)	54492869	107	78	103	37	32	18	10	28	19	0	0.378	1.000	1.000
494	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG10B(3), ALG12(1), ALG13(1), ALG14(2), ALG8(1), ALG9(1), B3GNT1(1), B3GNT7(2), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT5(1), CHPF(1), CHST1(1), CHST11(3), CHST12(1), CHST13(1), CHST2(1), CHST3(3), CHST4(1), CHSY1(1), DDOST(1), EXT1(3), EXT2(3), EXTL1(3), EXTL3(4), FUT8(2), GALNT10(5), GALNT11(2), GALNT12(2), GALNT13(1), GALNT14(3), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GALNTL5(3), GANAB(3), GCNT1(2), GCNT3(1), GCNT4(1), HS2ST1(1), HS3ST3A1(1), HS6ST1(3), HS6ST2(1), MAN1A1(2), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT3(1), MGAT4A(1), MGAT5(1), MGAT5B(2), NDST1(3), NDST2(5), NDST3(3), NDST4(6), OGT(1), RPN1(1), RPN2(2), ST3GAL1(2), ST3GAL3(1), ST6GAL1(1), ST6GALNAC1(1), UST(1), WBSCR17(2), XYLT1(6), XYLT2(1)	80618444	136	77	136	45	47	23	15	29	22	0	0.237	1.000	1.000
495	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(1), AKT3(1), CASP8(1), CD14(2), CD40(1), CD86(1), CXCL9(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IKBKB(1), IKBKE(1), IL12A(1), IL12B(1), IL6(1), IRAK1(1), IRAK4(2), IRF3(1), IRF5(1), LY96(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K7(2), MAP3K8(1), MAPK1(1), MAPK12(1), MAPK13(1), NFKB1(3), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(3), RIPK1(1), STAT1(1), TBK1(1), TICAM1(1), TIRAP(1), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR7(3), TLR8(2), TLR9(1), TNF(1), TRAF6(2)	66107644	113	77	108	46	32	20	15	29	17	0	0.665	1.000	1.000
496	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), BDKRB1(3), BDKRB2(2), C1QB(1), C1S(4), C2(1), C3(3), C3AR1(2), C4BPA(2), C5(3), C6(5), C8A(3), C8B(2), C9(3), CD46(2), CFB(3), CFD(1), CFH(9), CFI(1), CPB2(1), CR1(1), CR2(2), F10(3), F11(4), F12(1), F13A1(4), F13B(3), F2(2), F2R(2), F3(1), F5(5), F7(2), F8(1), FGA(5), FGB(2), FGG(1), KLKB1(2), MASP1(2), MASP2(2), PLAT(3), PLG(1), PROC(3), PROS1(3), SERPINA1(1), SERPINC1(2), SERPIND1(2), SERPINF2(1), SERPING1(2), VWF(6)	66545774	122	75	121	56	40	16	10	35	20	1	0.940	1.000	1.000
497	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(1), CALM1(1), CAMK4(4), CD69(2), CDKN1A(2), CEBPB(1), CNR1(5), CREBBP(8), CSNK2B(1), EGR3(1), EP300(7), FCER1A(1), GATA4(1), GSK3A(3), GSK3B(1), HRAS(4), IFNB1(1), IL10(1), IL4(1), IL6(1), ITK(3), KPNA5(3), MAP2K7(4), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKBIB(2), NFKBIE(1), NUP214(5), OPRD1(1), PAK1(1), PPIA(1), PPP3CB(1), PPP3CC(2), PTPRC(8), RELA(3), SP1(2), SP3(3), TNF(1), TRAF2(5), TRPV6(2), VAV1(3), VAV2(3), VAV3(4), XPO5(2)	67036779	118	74	116	41	37	18	13	33	17	0	0.336	1.000	1.000
498	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(3), CCKBR(2), CCR2(3), CCR3(1), CCR5(2), CELSR1(4), CELSR2(11), CELSR3(9), CHRM2(2), CHRM3(1), DRD4(1), EDNRA(1), EMR2(7), F2R(2), FSHR(2), GHRHR(1), GNRHR(4), GPR116(2), GPR132(1), GPR133(2), GPR17(2), GPR18(2), GPR55(2), GPR56(1), GPR84(1), GRM1(9), GRPR(1), HRH4(2), LGR6(3), LPHN2(6), LPHN3(9), NTSR1(3), OR2M4(2), P2RY11(2), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2)	48912646	111	71	109	38	46	17	10	28	10	0	0.0894	1.000	1.000
499	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(1), AKT3(1), CASP9(1), HRAS(4), KDR(7), KRAS(2), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NOS3(2), PIK3CA(16), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), PRKCG(1), PTGS2(5), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SH2D2A(1), SHC2(1), SPHK1(1), SPHK2(1), VEGFA(2)	52878113	113	71	107	34	31	20	16	23	22	1	0.127	1.000	1.000
500	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(3), BRAF(8), CREB1(1), DAXX(2), GRB2(1), HRAS(4), IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K11(1), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K8(1), MAP3K9(4), MAP4K1(2), MAP4K2(1), MAP4K4(1), MAP4K5(1), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(1), MEF2C(3), MEF2D(1), MYC(1), NFKB1(3), PAK1(1), PAK2(2), RAC1(1), RAF1(1), RELA(3), RIPK1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), RPS6KA5(3), RPS6KB2(2), SHC1(3), SP1(2), STAT1(1), TGFB2(2), TGFBR1(2), TRAF2(5)	69596004	114	70	111	39	33	20	17	23	20	1	0.353	1.000	1.000
501	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(7), ASH2L(1), CARM1(2), CTCFL(1), DOT1L(4), EED(1), EHMT1(1), EHMT2(3), EZH1(2), EZH2(1), HCFC1(3), HSF4(1), JMJD4(1), KDM6A(13), MEN1(4), NSD1(4), OGT(1), PAXIP1(2), PPP1CA(1), PRDM2(4), PRDM9(4), PRMT1(1), PRMT5(2), PRMT7(1), PRMT8(1), RBBP5(2), SATB1(1), SETD1A(3), SETD2(10), SETD7(1), SETD8(1), SETDB1(2), SETDB2(1), SETMAR(1), SUV420H1(2), SUV420H2(1), WHSC1(7), WHSC1L1(4)	87169135	102	67	102	33	34	10	8	20	30	0	0.625	1.000	1.000
502	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(2), CD14(2), CD1B(3), CD1C(4), CD1D(1), CD1E(1), CD2(1), CD34(1), CD36(1), CD37(1), CD38(1), CD3D(1), CD4(1), CD8A(1), CD8B(2), CD9(1), CR1(1), CR2(2), CSF1(1), CSF1R(5), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(2), FLT3LG(1), GP5(4), GP9(1), HLA-DRA(1), HLA-DRB5(1), IL11RA(1), IL1A(1), IL1R2(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL7(2), IL7R(1), ITGA1(2), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGAM(3), KIT(3), MME(2), TFRC(1), THPO(1), TNF(1), TPO(5)	59849115	99	65	99	42	27	20	6	31	15	0	0.700	1.000	1.000
503	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(3), ACSL1(3), ACSL5(1), ACSL6(3), ADIPOQ(1), ADIPOR1(2), ADIPOR2(1), AKT1(3), AKT2(1), AKT3(1), CAMKK1(2), CD36(1), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), G6PC(1), G6PC2(1), IKBKB(1), IRS1(3), IRS2(2), IRS4(3), JAK1(6), JAK2(1), JAK3(1), LEPR(2), NFKB1(3), NFKBIB(2), NFKBIE(1), PCK2(2), POMC(2), PPARA(2), PPARGC1A(4), PRKAA2(5), PRKAG1(3), PRKAG3(1), PRKCQ(3), PTPN11(1), RELA(3), RXRA(2), RXRB(2), RXRG(2), SLC2A1(1), STAT3(6), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5), TYK2(2)	60970844	109	65	107	35	38	24	13	22	12	0	0.112	1.000	1.000
504	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(8), DLL1(3), DLL3(3), DLL4(2), DTX1(5), DTX2(2), DTX3L(2), DTX4(2), DVL1(1), DVL2(3), DVL3(1), EP300(7), HDAC1(1), HDAC2(1), JAG1(1), JAG2(4), LFNG(1), MAML1(1), MAML2(2), MAML3(1), MFNG(1), NCOR2(7), NCSTN(2), NOTCH1(6), NOTCH2(7), NOTCH3(4), NOTCH4(4), NUMB(1), NUMBL(1), PTCRA(1), RBPJ(1), RBPJL(1), SNW1(3)	50702534	90	60	90	37	33	14	9	15	18	1	0.626	1.000	1.000
505	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(10), AXIN1(1), CCND3(1), CSNK1E(3), CTNNB1(13), DVL1(1), DVL2(3), DVL3(1), FZD1(2), FZD10(2), FZD2(4), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GSK3B(1), LDLR(3), MYC(1), PPP2R5E(2), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RAC1(1), RHOA(2), TCF7(1), WNT1(1), WNT2(2), WNT2B(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2)	44211785	91	60	87	35	26	14	11	25	15	0	0.365	1.000	1.000
506	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), AK3(1), CAD(9), CANT1(3), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), ENTPD1(1), ENTPD3(2), ENTPD4(2), ENTPD6(2), NME1(1), NME7(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3), PRIM2(2), RFC5(1), RRM2(1), TXNRD1(4), TYMS(1), UCK2(3), UMPS(3), UPP1(2), UPP2(1)	59497885	97	58	95	32	31	21	13	18	14	0	0.205	1.000	1.000
507	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AOC2(3), AOC3(1), AOX1(2), ASMT(2), CARM1(2), CAT(2), CYP1A1(1), CYP1A2(1), ECHS1(1), EHHADH(5), GCDH(1), HADH(3), HEMK1(1), HSD17B4(3), INMT(1), KMO(2), KYNU(3), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), NFX1(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), TDO2(1), TPH1(1), TPH2(2), WARS(1), WARS2(2)	44518359	68	54	68	28	18	11	8	19	11	1	0.771	1.000	1.000
508	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(8), CPEB1(1), EGFR(3), ERBB2(6), ERBB4(4), ETS1(1), ETV6(1), FMN2(8), GRB2(1), KRAS(2), MAPK1(1), NOTCH1(6), NOTCH2(7), NOTCH3(4), NOTCH4(4), PIWIL1(7), PIWIL2(4), PIWIL3(2), RAF1(1), SOS1(4), SOS2(1)	38349416	76	54	75	27	21	14	9	19	13	0	0.490	1.000	1.000
509	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), DAG1(2), EPHB2(4), GRB2(1), ITPKB(2), LYN(2), MAPK1(1), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PI3(1), PIK3CA(16), PIK3CD(5), PIK3R1(2), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(1), SHC1(3), SOS1(4), SOS2(1), SYK(2), VAV1(3)	38827278	73	53	69	32	27	14	7	15	10	0	0.754	1.000	1.000
510	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(14), B3GALT4(2), CDR1(1), DGKI(6), IL6ST(7), MRPL19(1), PIGK(1), RPL10(1), RPL11(4), RPL12(1), RPL19(2), RPL28(1), RPL29(1), RPL3(1), RPL34(1), RPL35A(1), RPL37(1), RPL3L(1), RPL5(3), RPL6(2), RPL7(2), RPL7A(1), RPL8(1), RPLP1(1), RPS10(1), RPS11(2), RPS20(1), RPS27A(2), RPS5(1), RPS6(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1), RPS6KB2(2), RPS9(1), SLC36A2(3), UBB(1), UBC(1)	38563595	78	52	78	42	22	19	6	17	14	0	0.992	1.000	1.000
511	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(3), ADCY6(2), ADCY8(7), CACNA1A(12), CACNA1B(3), GNAS(2), GNB1(1), GNB3(2), GRM4(2), ITPR3(6), KCNB1(4), PLCB2(1), PRKACA(2), PRKX(2), SCNN1B(4), SCNN1G(2), TAS1R2(4), TAS1R3(1), TAS2R13(1), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R5(1), TAS2R50(1), TRPM5(3)	41733569	73	51	73	32	34	7	8	16	8	0	0.725	1.000	1.000
512	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), CDS1(3), CDS2(1), CHAT(4), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), ESCO1(5), ESCO2(1), ETNK1(1), GNPAT(2), GPAM(2), GPD1L(1), GPD2(1), LCAT(1), NAT6(1), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2A(1), PPAP2B(1), PTDSS2(1), SH3GLB1(1)	47898875	73	48	73	26	17	12	8	18	18	0	0.548	1.000	1.000
513	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CFL1(1), CHN1(1), LIMK1(2), MAP3K1(5), MYLK(4), NCF2(3), PAK1(1), PDGFRA(3), PIK3CA(16), PIK3R1(2), PLD1(3), PPP1R12B(1), RAC1(1), RALBP1(1), TRIO(7), VAV1(3), WASF1(2)	25733523	57	46	54	21	18	10	6	15	8	0	0.644	1.000	1.000
514	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(4), DIAPH1(2), FYN(1), GSN(6), HRAS(4), ITGA1(2), MAPK1(1), MYLK(4), PFN1(1), PIK3CA(16), PIK3R1(2), PTK2(3), PXN(1), RAF1(1), ROCK1(5), SHC1(3), TLN1(4)	27618821	60	45	54	21	16	10	11	15	8	0	0.559	1.000	1.000
515	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(2), ALPPL2(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(6), DDX41(4), DDX47(3), DDX50(4), DDX56(2), DHFR(2), ENTPD7(1), EP400(4), ERCC2(3), ERCC3(1), FPGS(1), MOV10L1(2), RAD54B(4), RAD54L(2), RUVBL2(3), SETX(6), SKIV2L2(4), SMARCA2(3), SMARCA5(3), SPR(1)	46297477	67	45	67	32	17	15	10	15	10	0	0.874	1.000	1.000
516	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(3), BDKRB2(2), CALM1(1), CAV1(1), CHRNA1(1), FLT1(5), FLT4(4), KDR(7), NOS3(2), PDE2A(2), PDE3A(2), PDE3B(3), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKG1(1), RYR2(17), SLC7A1(1), SYT1(1), TNNI1(1)	29564467	62	44	61	26	25	12	4	11	9	1	0.482	1.000	1.000
517	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTR3(1), AKT1(3), ANGPTL2(1), CFL1(1), FLNA(1), FLNC(8), FSCN1(1), FSCN2(2), FSCN3(5), GDI1(1), LIMK1(2), MYH2(7), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PFN1(1), PFN2(3), RHO(1), ROCK1(5), ROCK2(1), WASF1(2)	35163980	66	44	64	29	26	11	5	18	6	0	0.710	1.000	1.000
518	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(2), BMP4(1), BMP5(4), BMP6(1), BMP7(3), BMP8B(1), BTRC(3), CSNK1A1L(1), CSNK1E(3), CSNK1G1(2), CSNK1G3(1), DHH(1), FBXW11(2), GLI1(5), GLI2(3), GLI3(3), GSK3B(1), HHIP(4), IHH(1), LRP2(5), PRKACA(2), PRKX(2), PTCH1(1), PTCH2(5), SHH(2), STK36(1), SUFU(1), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2)	44787036	76	43	76	29	27	18	10	12	9	0	0.257	1.000	1.000
519	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH4A1(2), AMD1(1), AOC2(3), AOC3(1), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(1), GLUD1(2), GOT1(2), GOT2(1), MAOA(2), MAOB(2), NOS1(3), NOS3(2), ODC1(1), OTC(1), P4HA1(4), P4HA2(3), P4HA3(3), P4HB(1), PYCR1(2)	32392593	59	42	58	24	18	10	5	18	8	0	0.743	1.000	1.000
520	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(2), ARHGDIB(1), BIRC2(1), CASP8(1), CASP9(1), CFLAR(2), DAXX(2), DFFA(4), GSN(6), LMNA(4), LMNB2(2), MAP2K7(4), MAP3K1(5), MAP3K5(2), MDM2(1), NFKB1(3), NUMA1(6), PAK2(2), PRKDC(11), PTK2(3), RASA1(1), RB1(3), RELA(3), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF2(5)	50774643	84	42	84	20	28	24	5	15	11	1	0.0349	1.000	1.000
521	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDH7A1(2), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), G6PC2(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHAL6A(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKL(2), PFKM(3), PFKP(3), PGAM2(1), PGK2(2), PGM3(1), PKLR(1)	42831659	72	42	71	19	23	11	10	15	13	0	0.0363	1.000	1.000
522	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(3), CREB1(1), DAXX(2), GRB2(1), HRAS(4), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP3K5(2), MAP3K7(2), MAP3K9(4), MAPKAPK5(1), MEF2A(1), MEF2C(3), MEF2D(1), MYC(1), PLA2G4A(4), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(3), STAT1(1), TGFB2(2), TGFBR1(2), TRAF2(5)	26838925	58	42	56	22	19	6	10	14	9	0	0.609	1.000	1.000
523	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(1), AASS(3), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), BBOX1(2), DOT1L(4), ECHS1(1), EHHADH(5), EHMT1(1), EHMT2(3), GCDH(1), HADH(3), HSD17B4(3), NSD1(4), PIPOX(2), PLOD1(2), PLOD3(3), RDH12(1), SETD1A(3), SETD7(1), SETDB1(2), SHMT1(1), SHMT2(1)	42583521	60	41	60	24	23	8	7	12	10	0	0.629	1.000	1.000
524	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), EGFR(3), GIT1(1), IGSF5(1), IKBKB(1), JAM2(1), LYN(2), MAP2K4(4), MAPK12(1), MAPK13(1), MET(4), NFKB1(3), NOD1(5), PAK1(1), PLCG1(1), PLCG2(3), PTPN11(1), RAC1(1), RELA(3), TCIRG1(1), TJP1(1)	51693008	63	41	63	25	16	13	7	19	8	0	0.634	1.000	1.000
525	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(2), EGF(3), EGFR(3), ETS1(1), HRAS(4), IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K5(2), MAPK1(1), MAPK13(1), NFKB1(3), PPP2CA(2), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), RAF1(1), RELA(3), RIPK1(1), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5)	36103983	62	40	60	26	16	13	9	16	8	0	0.664	1.000	1.000
526	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(1), AKT3(1), GRB2(1), IARS(2), IL13RA1(1), IL4(1), IL4R(3), INPP5D(3), JAK1(6), JAK2(1), JAK3(1), PI3(1), PIK3CA(16), PPP1R13B(3), SERPINA4(1), SHC1(3), SOS1(4), SOS2(1), STAT6(3), TYK2(2)	27165519	58	39	54	21	16	11	8	15	8	0	0.509	1.000	1.000
527	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD28(2), CD3D(1), DAG1(2), EPHB2(4), GRB2(1), ITK(3), ITPKB(2), LCP2(2), MAPK1(1), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PLCG1(1), PTPRC(8), RAF1(1), RASGRP2(1), RASGRP4(1), SOS1(4), SOS2(1), VAV1(3), ZAP70(6)	41058046	63	39	63	26	29	10	5	11	8	0	0.701	1.000	1.000
528	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(3), GNAS(2), GNB1(1), GNGT1(1), GRB2(1), HRAS(4), IGF1R(4), KLK2(1), MAPK1(1), MYC(1), PDGFRA(3), PPP2CA(2), PTPRR(1), RAF1(1), RPS6KA1(2), RPS6KA5(3), SHC1(3), SOS1(4), STAT3(6)	24287253	44	38	42	17	11	5	8	15	5	0	0.659	1.000	1.000
529	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(2), ADRB1(1), CHRM2(2), CHRM3(1), CHRM4(3), DRD2(1), DRD3(2), DRD4(1), DRD5(1), HRH1(1), HRH2(1), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2)	18863510	45	37	44	21	23	7	2	9	4	0	0.547	1.000	1.000
530	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(4), F12(1), F13B(3), F2(2), F5(5), F7(2), F8(1), FGA(5), FGB(2), FGG(1), LPA(5), PLAT(3), PLG(1), SERPINB2(1), SERPINF2(1), VWF(6)	25947576	46	36	46	27	15	7	4	13	6	1	0.975	1.000	1.000
531	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(1), EPRS(4), GLUD1(2), GLUD2(2), GOT1(2), GOT2(1), NOS1(3), NOS3(2), OTC(1), P4HA1(4), P4HA2(3), P4HA3(3), PARS2(3), PYCR1(2), PYCR2(1), PYCRL(1), RARS2(1)	26349202	48	36	48	21	20	7	3	12	6	0	0.762	1.000	1.000
532	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), B3GALNT1(1), B3GALT2(2), B3GALT4(2), B3GALT5(3), B3GNT1(1), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT6(3), FUT1(1), FUT2(1), FUT3(2), FUT4(1), GBGT1(1), PIGA(1), PIGB(2), PIGC(1), PIGG(3), PIGH(1), PIGK(1), PIGO(2), PIGQ(3), PIGT(1), ST3GAL1(2), ST3GAL3(1), ST3GAL6(1), ST6GALNAC3(1), ST6GALNAC4(2), ST8SIA1(1), ST8SIA5(1)	35674533	60	36	60	23	22	9	8	14	6	1	0.615	1.000	1.000
533	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(5), ARHGEF11(2), ARHGEF5(4), BAIAP2(1), CFL1(1), DIAPH1(2), GSN(6), LIMK1(2), MYLK(4), PFN1(1), PIP5K1B(1), PPP1R12B(1), ROCK1(5), TLN1(4), VCL(1)	33093626	48	36	47	18	6	9	7	12	14	0	0.767	1.000	1.000
534	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(9), CPS1(4), EARS2(1), EPRS(4), GAD1(2), GAD2(9), GFPT2(2), GLUD1(2), GLUD2(2), GLUL(1), GNPNAT1(1), GOT1(2), GOT2(1), GSR(1), NADSYN1(1), NAGK(1), PPAT(1), QARS(1)	29114463	49	35	49	24	20	6	4	9	10	0	0.872	1.000	1.000
535	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDH7A1(2), AMDHD1(3), AOC2(3), AOC3(1), ASPA(1), CARM1(2), CNDP1(3), HAL(2), HARS(1), HDC(2), HEMK1(1), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), UROC1(3)	29070335	45	35	45	20	12	9	5	12	7	0	0.813	1.000	1.000
536	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), CALM1(1), CD79A(2), GRB2(1), HRAS(4), LYN(2), MAP3K1(5), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYK(2), SYT1(1), VAV1(3)	28120457	45	34	43	18	17	6	6	9	7	0	0.591	1.000	1.000
537	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(1), CHAT(4), CPT1B(2), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), ETNK1(1), GNPAT(2), GPD2(1), LCAT(1), LGALS13(1), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(1), PLCG1(1), PLCG2(3), PPAP2A(1), PPAP2B(1)	36472163	56	34	56	27	14	9	7	14	12	0	0.890	1.000	1.000
538	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGTR1(3), ATF2(3), CALM1(1), EGFR(3), GRB2(1), HRAS(4), MAP2K4(4), MAP3K1(5), MAPK1(1), MEF2A(1), MEF2C(3), MEF2D(1), PAK1(1), PRKCA(2), PTK2(3), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYT1(1)	24540134	46	33	44	20	19	7	6	10	4	0	0.644	1.000	1.000
539	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(8), EP300(7), FYN(1), IL7(2), IL7R(1), JAK1(6), JAK3(1), NMI(1), PIK3CA(16), PIK3R1(2), STAT5B(2)	20521249	47	33	44	17	9	10	6	15	7	0	0.655	1.000	1.000
540	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), MCM10(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), NACA(3), PCNA(2), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), RFC1(5), RFC3(3), RFC5(1), RPA1(2), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1)	37310754	53	32	53	29	15	17	5	9	7	0	0.909	1.000	1.000
541	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN2(2), BCAR1(3), BCR(2), CAPN1(2), CAPNS1(2), CAV1(1), FYN(1), GRB2(1), HRAS(4), ITGA1(2), MAPK1(1), PPP1R12B(1), PTK2(3), PXN(1), RAF1(1), RAP1A(1), ROCK1(5), SHC1(3), SOS1(4), TLN1(4), VCL(1)	34680930	47	32	44	22	15	3	9	9	11	0	0.834	1.000	1.000
542	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CALM1(1), CAMK2A(1), CAMK2D(2), F2(2), FYN(1), GNA11(1), GNAI1(2), GNB1(1), GNGT1(1), GRB2(1), HRAS(4), JAK2(1), MAPK1(1), MYLK(4), PLCG1(1), PRKCA(2), RAF1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6), SYT1(1)	30689085	42	31	40	24	17	4	7	10	4	0	0.939	1.000	1.000
543	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ADCY3(2), ADCY9(5), ARF1(1), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(3), PRKCA(2), SEC61A1(1), SEC61A2(1)	27218153	40	31	40	19	11	5	4	13	7	0	0.823	1.000	1.000
544	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), GRB2(1), HRAS(4), IL6(1), IL6ST(7), JAK1(6), JAK2(1), JAK3(1), PTPN11(1), RAF1(1), SHC1(3), SOS1(4), STAT3(6)	17476763	37	31	35	14	8	8	6	6	9	0	0.619	1.000	1.000
545	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(2), ABAT(1), ACY3(1), ADSL(1), ADSS(1), AGXT(1), AGXT2(2), ASPA(1), ASRGL1(1), CAD(9), CRAT(1), DARS2(1), DDO(1), DLAT(1), DLD(2), GAD1(2), GAD2(9), GOT1(2), GOT2(1), NARS2(1), PC(2), PDHA1(1), PDHA2(4)	27836936	49	30	48	18	16	11	4	7	11	0	0.423	1.000	1.000
546	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(9), CPS1(4), EPRS(4), GAD1(2), GAD2(9), GLUD1(2), GLUL(1), GOT1(2), GOT2(1), NADSYN1(1), PPAT(1), QARS(1)	24486420	41	29	41	21	16	5	4	8	8	0	0.900	1.000	1.000
547	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CD4(1), CREBBP(8), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTPRC(8), ZAP70(6)	16932795	38	28	38	19	12	6	4	15	1	0	0.888	1.000	1.000
548	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CD4(1), CREBBP(8), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTPRC(8), ZAP70(6)	16932795	38	28	38	19	12	6	4	15	1	0	0.888	1.000	1.000
549	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASRGL1(1), CA1(1), CA12(1), CA13(1), CA14(2), CA2(3), CA3(1), CA4(2), CA5A(1), CA6(1), CA8(4), CA9(2), CPS1(4), CTH(2), GLUD1(2), GLUD2(2), GLUL(1), HAL(2)	15661324	34	28	34	12	9	9	1	10	5	0	0.480	1.000	1.000
550	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(4), DBH(5), GAD1(2), GAD2(9), HDC(2), MAOA(2), PAH(1), PNMT(1), SLC18A3(1), TPH1(1)	10553679	29	26	29	13	14	4	2	5	4	0	0.620	1.000	1.000
551	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(2), F2R(2), F3(1), F5(5), F7(2), FGA(5), FGB(2), FGG(1), PROC(3), PROS1(3), SERPINC1(2)	12120463	31	26	31	13	13	4	2	11	1	0	0.704	1.000	1.000
552	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(2), CAPNS1(2), EGF(3), EGFR(3), HRAS(4), ITGA1(2), MAPK1(1), MYLK(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTK2(3), PXN(1), TLN1(4)	23980892	39	26	37	21	11	3	6	15	4	0	0.942	1.000	1.000
553	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(1), ARF1(1), BTK(1), EEA1(4), GSK3A(3), GSK3B(1), LYN(2), PDPK1(1), PFKL(2), PFKM(3), PFKP(3), PLCG1(1), PRKCE(2), PRKCZ(3), RAC1(1), VAV2(3)	18420771	35	26	34	14	7	8	5	9	6	0	0.496	1.000	1.000
554	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(2), GNAI1(2), GNB1(1), GNGT1(1), HRAS(4), ITGA1(2), MAPK1(1), PLA2G4A(4), PLCB1(3), PRKCA(2), PTGS1(2), PTK2(3), RAF1(1), SYK(2), TBXAS1(2)	17978901	34	26	32	13	14	5	6	7	2	0	0.486	1.000	1.000
555	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(3), C6(5), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGAL(5), ITGB2(2), SELP(4), SELPLG(2), TNF(1), VCAM1(2)	18290146	33	25	32	17	15	4	6	6	2	0	0.739	1.000	1.000
556	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM1(1), CREB1(1), GNAI1(2), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), RAF1(1), SYT1(1)	25614852	37	24	35	18	11	2	7	13	4	0	0.898	1.000	1.000
557	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), HAL(2), HARS(1), HDC(2), MAOA(2), MAOB(2)	17915603	30	24	29	12	8	6	3	8	5	0	0.737	1.000	1.000
558	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), ALDH18A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AMD1(1), AOC2(3), AOC3(1), ARG1(1), ARG2(1), CPS1(4), MAOA(2), MAOB(2), NAGS(1), ODC1(1), OTC(1), SRM(1)	21566731	30	24	30	13	7	7	2	10	4	0	0.761	1.000	1.000
559	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(5), GNA13(2), GNB1(1), GNGT1(1), MYLK(4), PLCB1(3), PPP1R12B(1), PRKCA(2), ROCK1(5)	15254702	28	24	27	12	5	6	4	11	2	0	0.783	1.000	1.000
560	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), CDK7(2), ERCC3(1), GTF2E1(1), GTF2E2(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3B(3), POLR3D(1), TAF13(1), TAF5(1), TAF6(1)	25804357	33	24	33	21	8	6	5	10	4	0	0.974	1.000	1.000
561	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(1), ADSS(1), AGXT(1), AGXT2(2), ASPA(1), CAD(9), CRAT(1), DDO(1), GAD1(2), GAD2(9), GOT1(2), GOT2(1), PC(2)	19191428	35	23	35	15	13	5	4	5	8	0	0.674	1.000	1.000
562	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), CYP7A1(1), HADHB(1), SOAT2(3)	17111136	29	23	28	13	7	3	6	7	6	0	0.738	1.000	1.000
563	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(1), GPRC5B(1), GPRC5C(1), GRM1(9), GRM2(2), GRM3(4), GRM4(2), GRM5(5), GRM7(2), GRM8(2)	15500182	32	23	31	14	19	2	2	4	5	0	0.511	1.000	1.000
564	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(1), GALNT10(5), GALNT11(2), GALNT12(2), GALNT13(1), GALNT14(3), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GALNTL5(3), GCNT1(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(2), ST6GALNAC1(1), WBSCR17(2)	23806767	36	23	36	16	14	4	2	11	5	0	0.790	1.000	1.000
565	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IKBKB(1), IL1A(1), IL1RAP(2), IL6(1), IRAK1(1), IRAK2(4), IRAK3(4), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAP3K7(2), NFKB1(3), RELA(3), TGFB2(2), TNF(1), TRAF6(2)	21719886	35	23	35	16	13	8	3	5	6	0	0.683	1.000	1.000
566	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(2), DAG1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), NFAT5(1), PDE6B(2), PDE6C(1), PDE6D(1), SLC6A13(3), TF(1)	26309900	34	23	34	16	11	6	2	9	6	0	0.817	1.000	1.000
567	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(8), APOA4(2), APOC1(1), APOE(2), CETP(2), CYP7A1(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(3), LIPC(1), LPL(1), LRP1(12), SCARB1(2)	20196690	38	23	38	16	15	9	4	4	6	0	0.466	1.000	1.000
568	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CYP7A1(1), HADHB(1), RDH12(1), SLC27A5(2), SOAT2(3)	23223527	28	22	28	14	7	3	5	8	5	0	0.844	1.000	1.000
569	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(3), EGFR(3), GRB2(1), HRAS(4), MAPK1(1), PTPRB(5), RAF1(1), RASA1(1), SHC1(3), SOS1(4), SPRY3(1)	18407053	28	22	26	12	10	2	4	9	3	0	0.770	1.000	1.000
570	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(1), ACO2(1), CS(3), DLD(2), FH(3), IDH1(6), IDH3A(1), IDH3B(1), MDH1(1), PC(2), PCK2(2), SDHA(3), SDHB(2), SDHC(2), SUCLA2(1)	21997144	33	21	30	14	8	6	5	7	7	0	0.594	1.000	1.000
571	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), CD38(1), ENPP1(3), ENPP3(2), NADK(1), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT12(3)	15883813	24	21	24	10	6	5	1	6	6	0	0.688	1.000	1.000
572	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG(2), POLG2(1), POLI(1), POLL(1), POLM(1), POLQ(6), PRIM2(2), REV1(2), REV3L(5), RFC5(1)	29843113	36	21	36	14	8	10	3	7	8	0	0.778	1.000	1.000
573	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), CFL1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), LIMK1(2), MAPK1(1), PIK3C2G(1), PLCB1(3), PPP1R12B(1), PRKCA(2), PTK2(3), RAF1(1), ROCK2(1)	18407445	26	20	24	13	7	3	4	9	3	0	0.936	1.000	1.000
574	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C8B(2), C9(3), MASP1(2)	15309765	27	20	27	12	11	2	3	5	6	0	0.695	1.000	1.000
575	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E1(1), GTF2E2(1), GTF2H3(2), GTF2H4(1), STON1(1), TAF1(2), TAF13(1), TAF1L(10), TAF2(1), TAF4(1), TAF5(1), TAF5L(3), TAF6(1), TAF7L(3)	26566000	29	20	28	15	11	7	4	5	2	0	0.886	1.000	1.000
576	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	GRB2(1), HRAS(4), IL2RB(1), JAK1(6), JAK3(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2), SYK(2)	16980318	25	20	23	16	8	4	5	2	6	0	0.917	1.000	1.000
577	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(2), GNAI1(2), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), MAPK1(1), MYT1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RPS6KA1(2)	15085400	25	20	23	10	7	2	6	10	0	0	0.727	1.000	1.000
578	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(8), EP300(7), HDAC3(2), IKBKB(1), NFKB1(3), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2)	16426930	30	20	30	13	9	9	4	6	2	0	0.636	1.000	1.000
579	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), CASP8(1), CFLAR(2), MAP2K4(4), MAP3K3(1), MAP3K7(2), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5)	19984934	29	20	29	11	9	7	1	8	4	0	0.560	1.000	1.000
580	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C9(3), MASP1(2), MASP2(2)	15673730	27	19	27	13	10	2	4	6	5	0	0.737	1.000	1.000
581	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(4), F2(2), F2RL1(1), MAPK1(1), PLD1(3), PLD2(2), PTK2(3), RAF1(1), RASAL1(3), TEC(1), VAV1(3)	20176408	28	19	28	13	14	3	1	7	3	0	0.806	1.000	1.000
582	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8)	7934954	21	19	20	10	8	3	3	5	2	0	0.634	1.000	1.000
583	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGTR1(3), CMA1(2), COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4)	18336944	24	18	24	11	6	6	1	6	5	0	0.806	1.000	1.000
584	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), EDNRA(1), EGF(3), EGFR(3), HRAS(4), MYC(1), NFKB1(3), PLCG1(1), PRKCA(2), RELA(3)	15140155	24	18	22	12	6	3	4	10	1	0	0.831	1.000	1.000
585	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(4), F2(2), F2R(2), FGA(5), FGB(2), FGG(1), PLAT(3), PLG(1), SERPINB2(1)	9886796	22	18	22	18	11	2	1	8	0	0	0.993	1.000	1.000
586	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(1), IL22RA2(1), JAK1(6), JAK2(1), JAK3(1), STAT1(1), STAT3(6), STAT5B(2), TYK2(2)	13497691	23	18	23	10	1	5	3	8	6	0	0.752	1.000	1.000
587	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD4(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8)	8322645	21	18	20	10	8	3	3	6	1	0	0.670	1.000	1.000
588	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PPP2CA(2), PRKAA2(5), PRKAG1(3), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	11280071	23	17	23	10	5	4	3	10	1	0	0.821	1.000	1.000
589	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(3), GLB1(2), HEXB(2), LCT(6), SLC33A1(1), ST3GAL1(2), ST6GALNAC3(1), ST6GALNAC4(2), ST8SIA1(1), ST8SIA5(1)	12179707	23	17	23	15	12	3	2	4	2	0	0.925	1.000	1.000
590	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(1), AGTR1(3), ANPEP(2), CMA1(2), CPA3(1), CTSG(2), ENPEP(2), LNPEP(1), MAS1(1), MME(2), THOP1(2)	15576086	23	17	22	14	7	7	2	6	1	0	0.904	1.000	1.000
591	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C9(3)	12875060	23	16	23	11	9	2	3	4	5	0	0.726	1.000	1.000
592	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL4(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(3), TLR9(1)	13743026	19	16	18	12	5	3	1	7	3	0	0.880	1.000	1.000
593	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(4), DHCR24(2), DHCR7(1), EBP(1), GGCX(2), HMGCR(1), HSD17B7(2), IDI2(2), LSS(2), MVK(1), NQO1(2), SQLE(1), TM7SF2(1)	14064383	22	16	21	10	9	5	2	2	4	0	0.649	1.000	1.000
594	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CALM1(1), CAPN2(2), CAPNS1(2), EP300(7), HDAC1(1), HDAC2(1), MEF2D(1), NFATC1(2), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), SYT1(1)	17964790	28	16	28	13	10	3	3	9	3	0	0.783	1.000	1.000
595	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IL1A(1), IRAK1(1), MAP3K1(5), MAP3K7(2), NFKB1(3), RELA(3), RIPK1(1), TLR4(2), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2)	17746240	25	16	25	12	9	7	2	3	4	0	0.678	1.000	1.000
596	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP4K2(1), NFKB1(3), RELA(3), RIPK1(1), TANK(1), TNF(1), TNFRSF1A(1), TRAF2(5)	17605880	28	16	28	11	9	7	3	6	3	0	0.503	1.000	1.000
597	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(8), EP300(7), NCOA3(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RARA(1), RXRA(2)	15259656	29	15	29	13	10	4	6	8	1	0	0.687	1.000	1.000
598	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2E1(1), HDAC3(2), NCOA1(1), NCOA2(2), NCOA3(1), NCOR2(7), POLR2A(6), RARA(1), RXRA(2)	18282376	24	15	24	22	9	6	2	4	3	0	0.995	1.000	1.000
599	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4), P4HB(1), SLC23A2(1), SLC2A1(1)	18189682	21	14	21	10	8	5	0	3	5	0	0.800	1.000	1.000
600	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(2), CAPN1(2), CAPNS1(2), ITGA1(2), PTK2(3), PXN(1), RAC1(1), SPTAN1(2), TLN1(4)	21023448	21	13	21	13	8	1	2	5	5	0	0.948	1.000	1.000
601	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(1), CASP1(2), CASP8(1), GAPDH(1), ITCH(2), MAGI1(2), MAGI2(2), RERE(3), WWP1(3), WWP2(1)	17695052	19	12	19	10	4	3	3	4	5	0	0.884	1.000	1.000
602	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT7(2), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(1), CHST4(1), FUT8(2), ST3GAL1(2), ST3GAL3(1)	9169239	17	11	17	9	9	3	2	3	0	0	0.833	1.000	1.000
603	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(3), ITGAL(5), ITGB2(2), SELE(1)	8900916	12	11	11	7	6	0	3	3	0	0	0.811	1.000	1.000
604	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(3), HRAS(4), KLK2(1), MAPK1(1), RAF1(1)	6045731	10	10	8	11	4	0	4	1	1	0	0.996	1.000	1.000
605	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(2), KHK(1), LCT(6), MPI(1), PYGL(4), PYGM(1)	9842043	15	10	14	10	9	2	0	3	1	0	0.883	1.000	1.000
606	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PRKACA(2), PRKAR1A(2)	4843467	10	10	10	7	2	1	0	7	0	0	0.985	1.000	1.000
607	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), LPO(2), MPO(3), TPO(5)	6131553	14	10	14	6	8	2	0	4	0	0	0.597	1.000	1.000
608	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CSF1(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(3), TNFSF8(2)	9555858	16	10	16	10	6	4	3	2	1	0	0.831	1.000	1.000
609	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2)	7054909	14	9	14	8	4	1	1	8	0	0	0.937	1.000	1.000
610	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), CFTR(3), GNAS(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	9596071	14	9	14	8	4	3	1	6	0	0	0.920	1.000	1.000
611	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(5), JUND(2)	2756375	8	8	8	6	3	2	1	2	0	0	0.932	1.000	1.000
612	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5)	6108195	10	7	10	6	4	3	1	2	0	0	0.768	1.000	1.000
613	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CCR5(2), PLCG1(1), PRKCA(2), SYT1(1)	10139044	7	6	7	5	4	1	0	2	0	0	0.873	1.000	1.000
614	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), EIF4E(1), LDHB(1), LDHC(1), NCL(1)	6599531	6	4	6	4	1	3	1	1	0	0	0.819	1.000	1.000
615	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	533210	1	1	1	2	1	0	0	0	0	0	0.977	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		1268227	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
