rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(3)	1500904	7	6	7	0	3	1	1	2	0	0	0.146	0.00364	1.000
2	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(2), GH1(3), GHR(1), HRAS(4), IGF1R(4), PIK3R1(2), SHC1(3), SOD2(1), SOD3(1)	8207519	24	23	21	2	6	4	6	5	3	0	0.0200	0.00402	1.000
3	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(3), COQ7(1), NDUFA12(1), NDUFA13(2)	2929137	9	8	9	1	2	3	3	0	1	0	0.120	0.0125	1.000
4	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(1), AASS(3), KARS(2)	3479933	8	8	8	1	0	2	2	3	1	0	0.307	0.0228	1.000
5	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(1), EHHADH(5), SDS(1)	3557117	9	9	9	1	3	2	0	3	1	0	0.209	0.0233	1.000
6	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(2), AASDHPPT(1), AASS(3), KARS(2)	5143805	10	10	10	1	0	2	2	4	2	0	0.264	0.0262	1.000
7	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(1), EHHADH(5), HADH(3), HSD17B4(3), SIRT1(3), SIRT2(1), SIRT5(1), VNN2(1)	8706167	20	18	20	2	8	4	1	5	2	0	0.0423	0.0268	1.000
8	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(4), CDC25B(5), CDK7(2), CDKN1A(2), NEK1(3), WEE1(1)	5092069	17	13	17	2	8	2	0	2	5	0	0.193	0.110	1.000
9	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(1), SDHA(3), SDHB(2), SDHC(2), UQCRC1(2)	4880809	12	9	12	0	0	5	1	2	4	0	0.0186	0.116	1.000
10	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), ATF3(1), CYR61(1), DUSP14(1), EIF4E(1), IFRD1(1), IL1A(1), JUND(2), NR4A3(5), WDR1(1)	7921832	17	12	17	1	2	6	4	4	1	0	0.0187	0.122	1.000
11	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(2), HDC(2), PNMT(1), TPH1(1)	4435557	11	11	11	2	6	1	2	2	0	0	0.182	0.159	1.000
12	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), CASP9(1), GH1(3), GHR(1), NFKB1(3), PDPK1(1), PIK3R1(2), PPP2CA(2), RELA(3)	8766511	19	14	18	1	3	8	1	5	2	0	0.0158	0.172	1.000
13	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADH(3), HADHB(1), HSD17B4(3), MECR(1), PPT2(2)	6224096	12	12	12	2	6	3	0	1	2	0	0.150	0.184	1.000
14	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IL12A(1), IL12B(1)	2214277	4	4	4	1	1	0	0	2	1	0	0.623	0.199	1.000
15	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(1), NR1I3(2), PTGS1(2), PTGS2(5)	3960371	11	9	11	2	4	3	0	2	2	0	0.227	0.222	1.000
16	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(2), LARS(3), LARS2(2), PDHA1(1), PDHA2(4)	7394774	13	11	12	0	1	4	1	5	2	0	0.0215	0.227	1.000
17	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(2), GOT2(1), LDHB(1), LDHC(1), MPST(1)	5063710	12	8	12	0	5	3	2	1	1	0	0.0175	0.250	1.000
18	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(4), CDC25B(5), CDK7(2), SHH(2)	6419181	14	12	14	2	6	1	2	2	3	0	0.165	0.258	1.000
19	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(3), SEC61A2(1), SRP19(1), SRP54(2)	5589755	7	7	6	0	0	2	1	2	2	0	0.151	0.276	1.000
20	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(1), ENO3(1), FARS2(2), GOT1(2), GOT2(1), PAH(1), YARS(3)	6124126	14	9	14	1	7	4	1	1	1	0	0.0298	0.288	1.000
21	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR2(4), MTMR6(1), NFS1(1), THTPA(3)	4716616	10	9	10	2	3	1	3	1	2	0	0.283	0.324	1.000
22	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	377474	1	1	1	0	0	0	0	0	1	0	0.607	0.325	1.000
23	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), CD4(1), HLA-DRA(1), IL4(1), IL6(1)	3947339	6	6	6	1	3	1	0	1	1	0	0.398	0.333	1.000
24	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(4)	2881639	6	5	5	1	2	0	1	2	1	0	0.480	0.359	1.000
25	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(1)	1135539	2	2	2	0	0	2	0	0	0	0	0.516	0.360	1.000
26	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(3)	1332809	4	4	4	2	0	1	0	2	1	0	0.808	0.364	1.000
27	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(5), GCDH(1), SDHB(2), SDS(1)	5756404	13	10	13	2	5	4	0	3	1	0	0.149	0.366	1.000
28	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1)	4184643	7	6	7	1	2	1	1	2	1	0	0.243	0.369	1.000
29	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(5), HADHB(1), SDS(1)	6177211	14	13	14	3	5	2	1	4	2	0	0.321	0.373	1.000
30	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), HLA-DRA(1)	2240263	3	3	3	0	2	0	0	0	1	0	0.472	0.388	1.000
31	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(3), RB1(3), SP1(2), SP3(3)	4947836	12	11	12	3	2	2	1	2	4	1	0.498	0.393	1.000
32	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF2B5(1), EIF2S1(1), EIF4E(1), GSK3B(1), IGF1R(4), INPPL1(1), PDK2(1), PDPK1(1), PIK3R1(2), PPP2CA(2), RPS6(1)	12282026	19	18	18	2	2	5	3	6	3	0	0.0634	0.398	1.000
33	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	843933	1	1	1	1	0	1	0	0	0	0	0.872	0.413	1.000
34	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP5(1), ACPP(1), ACPT(3), ENPP1(3), ENPP3(2), RFK(1), TYR(2)	7172277	14	14	13	3	3	3	1	3	4	0	0.326	0.419	1.000
35	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	CDC25A(4), CDC25B(5), MYT1(2), WEE1(1)	5514447	12	8	12	1	6	2	0	2	2	0	0.118	0.421	1.000
36	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(1)	1555761	4	3	4	0	1	0	0	1	2	0	0.365	0.422	1.000
37	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(2), PDE6D(1)	2860952	5	4	5	1	2	2	0	0	1	0	0.430	0.438	1.000
38	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), GPHN(2), UBQLN1(2)	8799202	13	11	13	0	2	3	1	5	2	0	0.0157	0.449	1.000
39	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(8), AKT1(3), CDKN1A(2), CPB2(1), HIC1(4), HIF1A(2), IGFBP3(1), MDM2(1), NFKBIB(2), NQO1(2)	10071170	26	19	25	4	11	7	1	4	3	0	0.0501	0.459	1.000
40	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(1)	1657943	2	2	2	0	0	0	0	0	2	0	0.475	0.465	1.000
41	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(1)	1922079	3	3	3	0	1	1	0	1	0	0	0.367	0.471	1.000
42	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS2(1), SULT1E1(2), SUOX(1)	4518184	6	6	6	0	3	1	0	1	1	0	0.208	0.486	1.000
43	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(1), MYC(1), SP1(2), SP3(3), WT1(2)	4594936	9	7	9	2	0	1	1	4	3	0	0.468	0.487	1.000
44	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(2), ACAT1(2), ECHS1(1)	3997511	5	5	4	1	4	0	0	1	0	0	0.409	0.499	1.000
45	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(4), SNCAIP(3), UBE2F(1), UBE2L3(1)	4754453	11	8	11	2	3	2	1	5	0	0	0.258	0.505	1.000
46	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), UGDH(2), UGP2(1)	3623055	4	4	4	1	1	0	1	2	0	0	0.630	0.511	1.000
47	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD28(2), CD3D(1), CD4(1)	2377872	6	3	6	1	0	2	1	2	1	0	0.352	0.516	1.000
48	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), UGDH(2)	2842939	3	3	3	1	1	0	1	1	0	0	0.708	0.551	1.000
49	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(1), HMGCL(1), OXCT1(5)	2509642	9	5	9	2	2	2	2	3	0	0	0.415	0.566	1.000
50	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2), HSD3B2(2)	6759170	13	10	13	2	3	3	1	3	3	0	0.150	0.570	1.000
51	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2), HSD3B2(2)	6759170	13	10	13	2	3	3	1	3	3	0	0.150	0.570	1.000
52	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(1), HLA-DRA(1)	1746358	4	2	4	0	1	0	1	1	1	0	0.355	0.585	1.000
53	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(3), HSD17B2(1), HSD17B3(1), HSD17B4(3), HSD17B7(2), HSD3B1(2), HSD3B2(2)	5979653	15	12	14	5	2	4	2	3	3	1	0.530	0.604	1.000
54	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(3), CREB1(1), GRB2(1), HRAS(4), MAPK1(1), MEF2A(1), MEF2C(3), MEF2D(1), NTRK1(9), PIK3R1(2), PLCG1(1), RPS6KA1(2), SHC1(3)	12296761	32	26	29	5	17	7	5	1	2	0	0.0188	0.610	1.000
55	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(3), AOC3(1), CES1(3)	4423346	7	5	7	1	1	2	0	4	0	0	0.347	0.614	1.000
56	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(2), CTH(2), GOT1(2), GOT2(1), LDHAL6A(1), LDHB(1), LDHC(1), MPST(1), SDS(1), SULT4A1(1)	9256352	17	12	17	2	7	4	2	2	2	0	0.0614	0.614	1.000
57	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(4), NRG2(4), NRG3(3), PRKCA(2)	6653203	13	12	13	4	5	2	2	2	2	0	0.448	0.614	1.000
58	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(4), MMP14(1), MMP9(5)	5517903	10	9	8	3	4	0	4	2	0	0	0.427	0.633	1.000
59	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), PRKCE(2)	5835478	9	7	9	0	2	1	2	3	1	0	0.0506	0.633	1.000
60	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(1), PPARG(1), RXRA(2), TNF(1)	4289930	6	5	6	1	2	0	2	1	1	0	0.367	0.637	1.000
61	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1A(2), BMPR1B(2), BMPR2(3)	4610072	9	6	9	2	1	1	1	4	2	0	0.628	0.638	1.000
62	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(3), EIF4A1(1), EIF4B(2), EIF4E(1), EIF4G1(4), EIF4G2(1), EIF4G3(6), PDK2(1), PDPK1(1), PIK3R1(2), PPP2CA(2), RPS6(1), TSC1(2), TSC2(7)	18142356	34	25	33	3	10	5	1	11	7	0	0.0104	0.651	1.000
63	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(5), CDKN2A(1), E2F1(3), MDM2(1), MYC(1), PIK3R1(2), POLR1A(3), POLR1B(3), POLR1C(2), RAC1(1), RB1(3)	12781807	25	16	25	2	6	2	3	6	7	1	0.0438	0.656	1.000
64	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), FMOD(1), KERA(2)	2654832	5	5	5	2	1	0	0	3	1	0	0.869	0.670	1.000
65	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(1), STX1A(1)	2402720	3	3	3	1	2	1	0	0	0	0	0.585	0.687	1.000
66	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS7(1), DHRSX(5), PON1(1), PON2(3), PON3(1), RDH12(1)	6628567	13	8	13	1	7	0	2	3	1	0	0.0564	0.690	1.000
67	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), CBS(1), CTH(2), MARS2(1), MAT1A(3), PAPSS2(1), SEPHS1(1)	9104189	11	9	11	1	3	3	1	1	3	0	0.114	0.706	1.000
68	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2), ITPKB(2)	4444274	5	5	5	1	2	1	0	2	0	0	0.427	0.709	1.000
69	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(1), IL6(1), LDLR(3), LPL(1)	3937715	8	7	8	3	3	2	0	2	1	0	0.490	0.732	1.000
70	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	1214627	2	1	2	1	0	1	1	0	0	0	0.755	0.757	1.000
71	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT1(1), FUT2(1), FUT3(2), ST3GAL3(1)	5333690	11	9	11	3	2	2	2	5	0	0	0.494	0.770	1.000
72	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), GRB2(1), HRAS(4), KLK2(1), NTRK1(9), PIK3R1(2), PLCG1(1), PRKCA(2), SHC1(3), SOS1(4)	9877235	30	23	27	6	14	6	3	2	5	0	0.0844	0.803	1.000
73	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), FADS2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	7439179	13	9	13	2	2	1	1	4	5	0	0.242	0.813	1.000
74	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST3A1(1), XYLT1(6), XYLT2(1)	4737589	10	10	10	3	4	3	0	1	2	0	0.306	0.815	1.000
75	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST3A1(1), XYLT1(6), XYLT2(1)	4737589	10	10	10	3	4	3	0	1	2	0	0.306	0.815	1.000
76	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CUL1(2), E2F1(3), RB1(3), TFDP1(2)	6026497	10	7	10	3	4	0	2	0	3	1	0.516	0.821	1.000
77	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), GNGT1(1), HTR2C(3), PLCB1(3), TUB(2)	5294439	10	9	10	3	4	2	1	3	0	0	0.485	0.823	1.000
78	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(1), CUL1(2), E2F1(3), RB1(3), TFDP1(2)	6100856	11	7	11	3	4	0	2	0	4	1	0.426	0.825	1.000
79	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(3), EIF2B5(1), EIF2S1(1), EIF5(2), GSK3B(1), PPP1CA(1)	8541990	13	12	13	3	4	0	3	4	2	0	0.328	0.826	1.000
80	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), CD8A(1), CSF1(1), IL4(1), IL6(1), IL7(2), IL9(2)	4406485	9	7	9	3	1	1	1	2	4	0	0.672	0.830	1.000
81	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP5(1), ACPP(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), PON1(1)	21608147	46	37	45	8	18	5	6	10	7	0	0.0405	0.835	1.000
82	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(1), ABCG2(3), BCHE(3), CES1(3), CES2(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2)	16898592	21	14	21	0	7	2	1	7	4	0	0.00214	0.838	1.000
83	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(2), GOT1(2), GOT2(1), PAH(1), YARS(3), YARS2(3)	6409898	14	10	14	3	7	4	1	1	1	0	0.172	0.841	1.000
84	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(1), HLA-DRA(1), IL10(1), IL4(1)	2928620	6	4	6	2	3	0	1	1	1	0	0.569	0.842	1.000
85	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(8)	6226633	8	5	8	1	0	2	1	1	4	0	0.454	0.843	1.000
86	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CDC34(1), CUL1(2), E2F1(3), RB1(3), TFDP1(2)	6296235	12	8	12	4	4	1	2	0	4	1	0.498	0.847	1.000
87	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(1), GLUD1(2)	4074013	5	3	5	0	3	0	0	1	1	0	0.249	0.853	1.000
88	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), CTH(2), MUT(3)	3618920	6	5	6	4	1	1	0	2	2	0	0.961	0.854	1.000
89	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP5(1), ACPP(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CMBL(1), CYP3A43(1), CYP3A7(1), DHRS1(1), DHRS7(1), DHRSX(5), PON1(1), PON2(3), PON3(1)	13295315	26	19	25	5	9	3	3	6	5	0	0.0938	0.856	1.000
90	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(3), PLCB1(3), PRKCA(2), RELA(3)	6059591	11	8	11	2	3	4	1	3	0	0	0.197	0.861	1.000
91	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3), NR1H3(1), RXRA(2)	4022180	8	5	8	4	4	3	1	0	0	0	0.601	0.863	1.000
92	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	2327123	1	1	1	1	1	0	0	0	0	0	0.887	0.872	1.000
93	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	CDC25A(4), CDC25B(5), MYT1(2), RB1(3), WEE1(1)	7745040	15	11	15	3	6	2	1	2	3	1	0.356	0.879	1.000
94	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(2)	5088783	9	6	9	2	1	2	1	2	3	0	0.345	0.886	1.000
95	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(1), CDKN1A(2), CDKN2A(1), CFL1(1), E2F1(3), MDM2(1)	5300725	9	6	9	2	5	0	0	0	4	0	0.536	0.896	1.000
96	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(4), EPRS(4), FARS2(2), GARS(1), HARS(1), IARS(2), KARS(2), LARS(3), LARS2(2), MARS2(1), QARS(1), SARS(2), TARS(3), WARS(1), WARS2(2), YARS(3)	23701989	35	25	35	4	13	7	5	8	2	0	0.0115	0.896	1.000
97	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMD14(1), RPN1(1), RPN2(2), UBE3A(1)	9519258	15	8	15	1	3	3	2	3	4	0	0.0401	0.897	1.000
98	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD1(2), GLUD2(2)	3361215	4	4	4	2	2	1	0	1	0	0	0.784	0.898	1.000
99	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(1), CD3D(1), CD4(1), CD8A(1), IL6(1)	4570972	6	6	6	3	1	2	0	2	1	0	0.691	0.899	1.000
100	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(2), CDKN1A(2), E2F1(3), MDM2(1), PCNA(2), RB1(3)	8146407	13	8	13	2	4	2	1	1	4	1	0.233	0.900	1.000
101	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1), SHMT2(1)	3053315	2	2	2	0	1	0	0	0	1	0	0.393	0.900	1.000
102	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(5), DHFR(2), GART(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1), MTHFR(2), MTR(1), SHMT1(1), SHMT2(1), TYMS(1)	13239086	25	20	25	5	5	5	3	6	6	0	0.176	0.907	1.000
103	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(4), HMGB2(2), TOP2A(4), TOP2B(2)	6564891	12	9	12	4	3	3	1	2	3	0	0.763	0.907	1.000
104	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY2(4), CSNK1E(3), PER1(4)	6230589	12	7	12	2	4	4	1	3	0	0	0.214	0.910	1.000
105	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(1), JAK1(6), JAK2(1), STAT1(1)	6092911	9	7	9	3	0	3	1	2	3	0	0.671	0.910	1.000
106	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(3), BCAR1(3), GRB2(1), ILK(1), MAPK1(1), PDK2(1), PDPK1(1), PIK3R1(2), PTK2(3), SHC1(3), SOS1(4)	11675431	23	17	22	4	9	7	0	3	4	0	0.0782	0.918	1.000
107	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(10), AXIN1(1), BTRC(3), DLL1(3), DVL1(1), FZD1(2), GSK3B(1), NOTCH1(6), WNT1(1)	14556193	28	19	28	7	9	3	2	1	12	1	0.131	0.918	1.000
108	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1)	6464824	10	5	10	0	0	1	2	3	4	0	0.0544	0.922	1.000
109	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), ARSB(2), ARSD(1), ARSE(2), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD3B1(2), HSD3B2(2), STS(1), SULT1E1(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1)	20092640	32	26	32	5	7	6	2	11	6	0	0.0487	0.924	1.000
110	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(3), APC(10), AXIN1(1), CD14(2), DVL1(1), FZD1(2), GJA1(1), GNAI1(2), GSK3B(1), IRAK1(1), LEF1(2), LY96(1), NFKB1(3), PDPK1(1), PIK3R1(2), PPP2CA(2), RELA(3), TIRAP(1), TLR4(2), WNT1(1)	19780849	42	34	41	9	11	11	3	5	12	0	0.0405	0.927	1.000
111	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(5), DHFR(2), GART(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1), MTHFR(2), MTR(1), SHMT1(1), SHMT2(1), TYMS(1)	13984942	25	20	25	5	5	5	3	6	6	0	0.178	0.935	1.000
112	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(3), GRB2(1), HRAS(4), IGF1R(4), IRS1(3), MAPK1(1), PIK3R1(2), RAF1(1), SHC1(3), SOS1(4)	12416513	26	22	23	6	9	3	6	4	4	0	0.206	0.935	1.000
113	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL16(5), IL1A(1), IL4(1), IL6(1), IL9(2), TNF(1)	7357338	15	13	15	5	5	3	1	3	3	0	0.425	0.938	1.000
114	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR3(1), PAK1(1), PDGFRA(3), PIK3R1(2), RAC1(1)	8290896	8	8	8	2	3	1	1	1	2	0	0.610	0.939	1.000
115	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(1), HRAS(4), SHC1(3), SOS1(4)	6472275	13	11	11	4	7	1	3	0	2	0	0.390	0.939	1.000
116	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(3), CHST12(1), CHST13(1), PAPSS2(1), SULT1A1(1), SULT1E1(2), SUOX(1)	6801496	12	11	12	4	7	1	1	1	2	0	0.495	0.946	1.000
117	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(1), GAD1(2), GAD2(9)	4229060	12	11	12	7	6	1	1	2	2	0	0.830	0.946	1.000
118	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR3(1), RAC1(1), WASF1(2)	6004781	5	5	5	2	1	1	1	2	0	0	0.738	0.948	1.000
119	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(2), PLCB1(3), PLCG1(1), PRKCA(2), VAV1(3)	7862314	14	12	13	4	5	3	0	5	1	0	0.531	0.948	1.000
120	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(3), ALAS2(1), CPOX(1), HMBS(1)	5476540	6	5	6	2	2	1	0	2	1	0	0.633	0.949	1.000
121	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BCL2L11(1), CASP9(1), CES1(3)	7875441	7	5	7	1	0	1	0	6	0	0	0.494	0.949	1.000
122	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(3), DPYS(2), ENPP1(3), ENPP3(2), PANK1(3), PANK2(3), PANK3(1), PPCS(1)	10284280	19	17	18	5	4	5	3	3	4	0	0.384	0.949	1.000
123	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	DCXR(2), UGDH(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1)	12998242	16	13	16	3	3	4	1	6	2	0	0.235	0.950	1.000
124	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(2), ACADVL(1), ACSL1(3), CPT1A(1), CPT2(2), EHHADH(5), PECR(1), SCP2(3), SLC25A20(1)	12426847	19	15	18	4	8	3	1	2	5	0	0.217	0.958	1.000
125	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(5)	5310767	11	7	11	3	3	2	2	4	0	0	0.492	0.959	1.000
126	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(2)	2274600	3	2	3	2	1	2	0	0	0	0	0.769	0.959	1.000
127	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(3), EXTL1(3), EXTL3(4), GLCE(1), HS2ST1(1), HS3ST3A1(1), HS6ST1(3), HS6ST2(1), NDST1(3), NDST2(5), NDST3(3), NDST4(6)	15152444	37	30	37	9	10	8	7	7	5	0	0.119	0.960	1.000
128	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(2), CBS(1), CTH(2), DNMT1(3), DNMT3A(2), DNMT3B(6), MARS2(1), MAT1A(3), MTR(1)	12787066	23	17	23	5	9	4	2	2	6	0	0.114	0.960	1.000
129	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMD1(2), PSMD11(1), PSMD2(1), PSMD6(1)	11847507	16	9	16	1	3	2	2	5	4	0	0.0481	0.961	1.000
130	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP5(1), ACPP(1), ACPT(3), ENPP1(3), ENPP3(2), LHPP(1), MTMR2(4), MTMR6(1), RFK(1), TYR(2)	11112397	20	18	19	5	4	4	3	4	5	0	0.299	0.961	1.000
131	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(6), STAT1(1), STAT2(2), TYK2(2)	7997376	12	9	12	5	1	3	1	3	4	0	0.735	0.962	1.000
132	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(3), JAK1(6), JAK2(1), TYK2(2)	7753804	13	10	13	4	1	3	2	3	4	0	0.496	0.962	1.000
133	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(3), JAK1(6), JAK2(1), TYK2(2)	7753804	13	10	13	4	1	3	2	3	4	0	0.496	0.962	1.000
134	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(2), ALOX5(1), DPEP1(2), LTC4S(1), PLA2G2A(1), PLA2G6(2), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2)	11011159	21	14	21	4	9	4	0	5	3	0	0.0741	0.963	1.000
135	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2), PDXK(1), PSAT1(1)	3590408	4	3	4	3	0	2	0	1	1	0	0.895	0.968	1.000
136	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOC(3)	2883535	5	3	5	2	0	2	2	1	0	0	0.649	0.968	1.000
137	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), HMOX1(2), IL10(1), IL10RA(2), IL1A(1), IL6(1), JAK1(6), STAT1(1), STAT3(6), TNF(1)	8989834	22	17	22	8	6	4	3	5	4	0	0.468	0.969	1.000
138	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(2), EPX(4), LPO(2), MPO(3), PRDX1(1), SHMT1(1), SHMT2(1), TPO(5)	8682929	19	15	19	5	9	2	1	5	2	0	0.270	0.971	1.000
139	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), KEAP1(4), MAFF(1), MAPK1(1), NFE2L2(1), PRKCA(2)	6501032	10	8	10	3	4	2	2	2	0	0	0.376	0.971	1.000
140	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD2(1), CD3D(1), CD4(1), IL12A(1), IL12B(1), IL12RB2(1), JAK2(1), STAT4(6), TYK2(2)	10735192	17	13	17	5	1	4	2	6	4	0	0.436	0.971	1.000
141	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(4), CDC25B(5), GRB2(1), PRKCA(2), PTPRA(5)	6781748	17	12	17	5	8	3	1	3	2	0	0.377	0.971	1.000
142	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB3A(1)	3132633	3	3	3	4	1	0	0	1	1	0	0.975	0.971	1.000
143	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), NAT2(1), XDH(1)	5907141	11	8	11	4	6	1	1	2	1	0	0.603	0.973	1.000
144	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	IDI2(2), SQLE(1)	3129059	3	2	3	2	1	0	1	0	1	0	0.791	0.975	1.000
145	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(1), CREB1(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(1)	7057611	8	8	8	5	2	1	1	1	3	0	0.946	0.975	1.000
146	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(1), JAK3(1), MAPK1(1), STAT3(6), TYK2(2)	8612725	17	14	17	9	2	4	2	5	4	0	0.881	0.977	1.000
147	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(3), RELA(3), TNFRSF13B(3), TRAF2(5), TRAF5(1), TRAF6(2)	10668296	17	9	17	3	6	4	1	4	2	0	0.111	0.977	1.000
148	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(3), CDKN1A(2), E2F1(3), HRAS(4), MAPK1(1), NFKB1(3), PAK1(1), PIK3R1(2), RAC1(1), RAF1(1), RB1(3), RELA(3), TFDP1(2)	12968362	29	21	26	6	8	5	8	2	5	1	0.125	0.979	1.000
149	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC1(3), APOBEC2(1), APOBEC3B(4), APOBEC3G(1)	5431405	12	10	12	5	5	1	2	2	2	0	0.761	0.979	1.000
150	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT5(1), FUT8(2), ST3GAL1(2), ST3GAL3(1)	5778649	12	9	12	4	6	2	0	4	0	0	0.603	0.979	1.000
151	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ECHS1(1), EHHADH(5), SDS(1)	8937545	19	16	18	6	6	3	3	4	3	0	0.457	0.980	1.000
152	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(1), CYP1A2(1), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2J2(1), CYP3A43(1), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), RDH12(1)	17628767	31	21	31	6	10	2	3	10	6	0	0.155	0.980	1.000
153	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(3), CREB1(1), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAPK1(1), NFKB1(3), PIK3R1(2), RB1(3), RELA(3), SP1(2)	12680547	25	17	24	5	6	9	2	2	5	1	0.113	0.982	1.000
154	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(2), UBE2C(1), UBE2I(1), UBE2L3(1), UBE2S(1), UBE3A(1)	7766740	8	7	8	3	2	1	2	2	1	0	0.606	0.982	1.000
155	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(4), PCYT1A(1), PDHA1(1), PDHA2(4), SLC18A3(1)	5098348	12	9	11	6	4	4	0	1	3	0	0.537	0.983	1.000
156	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ENO1(3), HK1(2), PFKL(2), PKLR(1)	6798617	8	5	8	4	5	0	0	0	3	0	0.704	0.983	1.000
157	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS7(1), DHRSX(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1)	12248012	15	11	15	3	6	0	2	3	4	0	0.265	0.984	1.000
158	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH12(1)	3513530	1	1	1	1	1	0	0	0	0	0	0.894	0.985	1.000
159	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	FLT3(2), IL1A(1), IL6(1), IL9(2), TGFB2(2)	6008566	8	8	8	9	1	1	3	1	2	0	0.994	0.986	1.000
160	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), SHMT1(1), SHMT2(1)	4009978	3	3	3	2	1	1	0	0	1	0	0.739	0.986	1.000
161	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(2), EPX(4), LPO(2), MPO(3), MTHFR(2), SHMT1(1), SHMT2(1), TPO(5)	8551912	20	16	20	5	10	3	1	4	2	0	0.214	0.987	1.000
162	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(3), ERBB3(5), NRG1(4)	7598482	15	13	15	5	2	2	0	9	2	0	0.648	0.987	1.000
163	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(8), ZAP70(6)	6687301	18	15	18	7	7	4	2	5	0	0	0.493	0.987	1.000
164	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(3), ALAS2(1), HMBS(1)	5588764	5	4	5	2	2	1	0	1	1	0	0.715	0.988	1.000
165	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(1)	4146376	8	8	8	7	4	2	0	1	1	0	0.947	0.989	1.000
166	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(2), ALPPL2(2), DHFR(2), FPGS(1), SPR(1)	4783176	9	8	9	6	3	3	0	1	2	0	0.851	0.989	1.000
167	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FYN(1), THBS1(3)	5462957	5	4	5	2	2	1	1	1	0	0	0.628	0.989	1.000
168	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(2), AKT1(3), ASAH1(1), GNAI1(2), GNB1(1), GNGT1(1), ITGAV(3), MAPK1(1), PDGFA(2), PDGFRA(3), PIK3R1(2), PLCB1(3), PRKCA(2), PTK2(3), RAC1(1), SMPD2(2), SPHK1(1)	18623703	33	25	32	7	12	8	2	8	3	0	0.0899	0.989	1.000
169	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXB(2), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2)	14998628	28	20	28	9	14	3	1	4	6	0	0.348	0.989	1.000
170	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(6), PTPRU(4), REG1A(1), STAT1(1), STAT2(2), TYK2(2)	9219819	17	12	17	7	4	4	1	4	4	0	0.668	0.990	1.000
171	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(1), PRKCA(2), TGM2(1)	3607014	6	5	6	4	3	1	0	1	1	0	0.814	0.990	1.000
172	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	11096494	17	13	17	4	3	3	2	5	4	0	0.367	0.990	1.000
173	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	11096494	17	13	17	4	3	3	2	5	4	0	0.367	0.990	1.000
174	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	11096494	17	13	17	4	3	3	2	5	4	0	0.367	0.990	1.000
175	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), BHMT(2), CBS(1), CTH(2), DNMT1(3), DNMT3A(2), DNMT3B(6), MARS2(1), MAT1A(3), MTAP(1), MTR(1), SRM(1)	15213906	26	18	26	7	11	4	2	3	6	0	0.178	0.990	1.000
176	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(2), CASP9(1), DAXX(2), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1), TNF(1)	8362558	11	10	11	6	2	1	1	4	3	0	0.945	0.990	1.000
177	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(1), CS(3), HAO1(2), MDH1(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1)	9460948	15	11	15	4	2	2	5	3	3	0	0.347	0.991	1.000
178	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(1), GPR171(1), GPR18(2), GPR39(3), GPR45(2), GPR68(2), GPR75(2)	7250189	15	8	15	4	5	2	0	7	1	0	0.374	0.991	1.000
179	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(1), FUT2(1), ST8SIA1(1)	4515877	4	4	4	5	0	3	0	0	1	0	0.972	0.991	1.000
180	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(3), MDH1(1), ME1(3), PC(2), PDHA1(1)	6802237	12	7	12	3	1	3	2	2	4	0	0.309	0.991	1.000
181	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1(3), CAMK1G(2), CAMK2A(1), CAMK2D(2), CAMK4(4), CAMKK1(2), CREB1(1), SYT1(1)	8491574	17	11	17	6	7	2	0	6	2	0	0.559	0.992	1.000
182	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), MAP2K3(1), NFATC1(2), NFATC2(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	8913820	13	10	13	5	4	2	2	5	0	0	0.521	0.992	1.000
183	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(1), CCNE2(1), CDKN2A(1), E2F1(3)	6291671	6	5	6	2	2	1	0	1	2	0	0.648	0.992	1.000
184	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXB(2), LCT(6), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2)	12164815	23	18	23	8	10	3	1	3	6	0	0.488	0.992	1.000
185	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1)	5873133	12	10	11	5	3	1	3	3	2	0	0.736	0.992	1.000
186	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1)	5873133	12	10	11	5	3	1	3	3	2	0	0.736	0.992	1.000
187	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(3), FH(3), MDH1(1), SDHA(3), SUCLA2(1)	6939714	12	7	12	3	0	2	3	4	3	0	0.329	0.993	1.000
188	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP3(2), ARFGEF2(2), CLTB(1), COPA(2), GBF1(6), GPLD1(3), KDELR1(1), KDELR3(1)	12001371	19	14	19	5	7	4	2	2	4	0	0.223	0.993	1.000
189	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(8), DFFA(4), GZMA(1), HMGB2(2), NME1(1), PRF1(2)	7814343	18	14	18	9	4	5	2	4	3	0	0.831	0.994	1.000
190	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(1), CS(3), HAO1(2), MDH1(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1)	9904861	15	11	15	4	2	2	5	3	3	0	0.345	0.994	1.000
191	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CYP2C19(4), CYP2C9(3), DHRS1(1), DHRS7(1), DHRSX(5), ECHS1(1), EHHADH(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1)	22799486	36	28	36	7	13	3	5	9	6	0	0.0891	0.994	1.000
192	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(2), HDAC9(2), MEF2A(1), MEF2C(3), MEF2D(1)	5592666	12	10	12	5	5	2	1	4	0	0	0.642	0.994	1.000
193	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	EIF2S1(1), NFKB1(3), RELA(3)	6550385	7	4	7	2	1	3	2	1	0	0	0.430	0.994	1.000
194	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1R(3), TNF(1)	4825463	5	5	5	3	3	0	0	0	2	0	0.861	0.995	1.000
195	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), DPYD(3), DPYS(2), ENPP1(3), ENPP3(2), ILVBL(3), PANK1(3), PANK2(3), PANK3(1), PPCS(1)	12774758	23	19	22	7	5	5	3	4	6	0	0.477	0.995	1.000
196	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(2), IARS2(1), ILVBL(3), LARS(3), LARS2(2), PDHA1(1), PDHA2(4), VARS(4), VARS2(4)	13665443	26	18	25	5	5	5	1	10	5	0	0.184	0.995	1.000
197	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(1), CCND3(1), CCNH(1), CDC25A(4), CDK7(2), CDKN1A(2), CDKN2A(1), E2F1(3), RB1(3), RBL1(2), TFDP1(2)	11571372	22	14	22	8	7	3	3	2	6	1	0.543	0.995	1.000
198	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(3), CASP9(1), HRAS(4), NFKB1(3), PIK3R1(2), RAC1(1), RAF1(1), RALBP1(1), RALGDS(2), RELA(3), RHOA(2)	12305615	23	19	19	6	3	6	6	6	2	0	0.253	0.995	1.000
199	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(1), ACO2(1), FH(3), MDH1(1), SDHB(2), SUCLA2(1)	5949838	9	6	9	3	0	3	3	2	1	0	0.463	0.995	1.000
200	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(2), GOT2(1), TYR(2)	3455567	5	5	5	3	3	1	0	1	0	0	0.812	0.995	1.000
201	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(1), FUT2(1), GBGT1(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1)	7433064	12	11	12	8	5	5	0	0	2	0	0.869	0.996	1.000
202	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	DCXR(2), UGDH(2), UGP2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3), XYLB(1)	20209130	34	25	34	7	5	5	4	15	5	0	0.168	0.996	1.000
203	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(2), BIK(1), BIRC2(1), CASP8(1), CASP9(1), DFFA(4)	9942795	10	6	10	2	1	5	0	3	1	0	0.347	0.996	1.000
204	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(4), GLUD1(2), GOT1(2)	5754870	9	7	9	5	4	1	0	3	1	0	0.854	0.996	1.000
205	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(1), CASP8(1), CFLAR(2), DAXX(2), DFFA(4), FAF1(4), LMNA(4), LMNB2(2), MAP2K4(4), MAP3K1(5), MAP3K7(2), PAK1(1), PAK2(2), PRKDC(11), PTPN13(1), RB1(3), RIPK2(2), SPTAN1(2)	29878586	54	34	54	8	18	12	5	9	9	1	0.0101	0.996	1.000
206	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(1), HLA-A(1), ICAM1(1), ITGAL(5), ITGB2(2), PRF1(2)	6429255	13	12	12	9	7	1	0	3	2	0	0.882	0.996	1.000
207	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(2), CD3D(1), CD86(1), GRB2(1), HLA-DRA(1), ITK(3), PIK3R1(2), PTPN11(1)	7852540	12	8	12	4	7	2	1	0	2	0	0.509	0.996	1.000
208	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(8), EP300(7), ESR1(2), MAPK1(1), PELP1(2)	10811985	20	16	20	6	8	3	2	4	3	0	0.395	0.996	1.000
209	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(2), ACOX3(1), ELOVL6(3), FADS2(1), FASN(5), PECR(1), SCD(2)	10405150	17	10	17	6	5	0	2	4	6	0	0.587	0.996	1.000
210	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(2), HK2(4), HK3(4), IMPA1(2), PGM3(1)	7527964	17	9	17	4	9	2	1	3	2	0	0.211	0.996	1.000
211	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(2), CAPNS1(2), GSK3B(1), PPP2CA(2)	6791163	7	5	7	4	3	1	0	1	2	0	0.885	0.996	1.000
212	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(1), HLA-DRA(1), IFNGR2(1), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3)	9366151	12	9	12	4	2	1	1	3	5	0	0.645	0.996	1.000
213	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(1), B3GALT5(3), FUT1(1), FUT2(1), GBGT1(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1)	7893220	16	14	16	8	7	5	0	2	2	0	0.721	0.997	1.000
214	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), SP1(2), SP3(3), SYT1(1)	15469956	24	18	24	6	7	2	1	7	7	0	0.344	0.997	1.000
215	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(3), ITGAL(5), ITGAM(3), ITGB2(2), SELE(1), SELP(4)	11703103	19	17	18	7	9	1	5	3	1	0	0.400	0.997	1.000
216	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(3), C6(5), C8A(3), C9(3)	9284566	17	11	17	8	5	2	1	4	5	0	0.751	0.997	1.000
217	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(3), FBP1(2), FBP2(1), GOT1(2), GOT2(1), MDH1(1), ME1(3), ME2(1), ME3(1), PKLR(1), TKT(2)	13251252	18	10	18	3	4	4	3	5	2	0	0.0858	0.998	1.000
218	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATR(3)	6611195	3	3	3	2	1	0	0	1	1	0	0.944	0.998	1.000
219	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1)	9870752	16	11	16	4	7	3	2	3	1	0	0.287	0.998	1.000
220	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNB1(1), NFKB1(3), RELA(3), TNFSF11(1), TRAF6(2)	8145196	10	5	10	2	2	3	1	2	2	0	0.286	0.998	1.000
221	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(6), JAK2(1), PLA2G2A(1), PTPRU(4), REG1A(1), STAT1(1)	8491773	14	10	14	5	3	4	1	4	2	0	0.562	0.998	1.000
222	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), PRKAG1(3), PRKAR2A(1)	7444424	9	4	9	2	3	2	2	2	0	0	0.326	0.998	1.000
223	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(2), ADORA3(3), P2RY1(1), P2RY2(2), P2RY6(1)	4409058	12	9	12	6	5	2	1	3	1	0	0.651	0.998	1.000
224	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), DHRS1(1), DHRS7(1), DHRSX(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1)	18432810	22	14	22	4	8	1	3	5	5	0	0.121	0.998	1.000
225	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(8), DAXX(2), HRAS(4), PAX3(4), PML(1), RARA(1), RB1(3), SIRT1(3), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1)	13392447	31	25	29	9	7	4	10	6	3	1	0.326	0.998	1.000
226	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), UGDH(2)	6265694	10	9	10	5	1	1	3	4	1	0	0.851	0.998	1.000
227	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2)	9769159	15	12	15	5	3	2	3	5	2	0	0.519	0.998	1.000
228	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(3), FURIN(1), NOTCH1(6)	6773733	10	5	10	5	5	1	1	1	1	1	0.639	0.998	1.000
229	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFA5(1), NDUFB7(1), NDUFS2(2), NDUFV1(1)	5118808	7	6	7	3	1	1	3	2	0	0	0.736	0.999	1.000
230	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	DUSP1(1), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK12(1), MAPK13(1), MAPK8IP3(4), MAPKAPK5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PIK3CD(5), PIK3R1(2), SYT1(1), TRAF2(5), TRAF5(1), TRAF6(2)	23067751	40	25	40	7	17	5	0	8	10	0	0.0276	0.999	1.000
231	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(10), MAP2(4), PPP1CA(1), PPP2CA(2), PRKAG1(3), PRKAR2A(1), PRKCE(2)	13446229	23	16	23	8	1	3	4	10	5	0	0.736	0.999	1.000
232	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(2), ARHGEF1(5), F2(2), F2R(2), GNA13(2), GNAI1(2), GNB1(1), GNGT1(1), MAP3K7(2), PIK3R1(2), PLCB1(3), PPP1R12B(1), PRKCA(2), ROCK1(5)	17381186	32	26	31	9	11	4	4	9	4	0	0.368	0.999	1.000
233	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(1), IL4(1), IL4R(3), IRS1(3), JAK1(6), JAK3(1), SHC1(3), STAT6(3)	10820307	24	20	23	9	7	4	2	7	4	0	0.655	0.999	1.000
234	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(1), ENPP1(3), ENPP3(2), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5E(1), NT5M(1)	10732148	15	15	15	8	3	3	1	5	3	0	0.833	0.999	1.000
235	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IFNGR2(1), IKBKB(1), JAK2(1), NFKB1(3), RB1(3), RELA(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(2), WT1(2)	12707361	19	10	19	4	4	6	3	2	3	1	0.153	0.999	1.000
236	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(2), GREB1(2), MTA1(2), TUBA8(1)	7905096	9	8	9	6	3	1	3	0	2	0	0.849	0.999	1.000
237	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT3(2), CHPF(1), CHST11(3), CHST12(1), CHST13(1), CHST3(3), CHSY1(1), DSE(1), UST(1), XYLT1(6), XYLT2(1)	10025365	22	20	22	8	12	3	1	3	3	0	0.377	0.999	1.000
238	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(1), PRKCA(2)	4925307	5	5	5	7	2	1	0	1	1	0	0.989	0.999	1.000
239	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), FHL5(4), FSHR(2), GNAS(2)	7049295	10	8	10	4	2	2	2	4	0	0	0.764	0.999	1.000
240	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(1), DHRS7(1), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1)	11060009	19	11	19	7	7	2	2	4	4	0	0.558	0.999	1.000
241	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(3), MBTPS1(3), MBTPS2(1), SCAP(2), SREBF1(2), SREBF2(2)	8745598	14	10	14	8	5	1	0	5	3	0	0.905	0.999	1.000
242	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(2), HK2(4), HK3(4), IMPA1(2), PGM3(1)	8571630	17	9	17	4	9	2	1	3	2	0	0.193	0.999	1.000
243	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR7(3), CD28(2), CD4(1), IFNGR2(1), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3), TGFB2(2)	14647280	26	20	26	7	3	2	3	12	6	0	0.441	0.999	1.000
244	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), JAK1(6), JAK2(1), JAK3(1), PIAS3(2), PTPRU(4), REG1A(1), STAT3(6)	11199244	22	16	22	9	3	6	3	6	4	0	0.648	0.999	1.000
245	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PCYT1A(1), PCYT1B(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1)	10296349	14	9	14	8	3	3	2	3	3	0	0.883	0.999	1.000
246	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(1), AKT3(1), BPNT1(2), GRB2(1), ILK(1), MAPK1(1), PDK1(2), PIK3CD(5), RBL2(2), SHC1(3), SOS1(4)	12826079	26	23	25	9	11	4	2	4	5	0	0.451	0.999	1.000
247	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY2(4), CSNK1E(3), NPAS2(1), NR1D1(3), PER1(4), PER2(4), PER3(2)	12567640	22	15	22	6	8	5	1	6	2	0	0.312	0.999	1.000
248	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(4), CALCRL(1), CD97(2), CRHR2(2), ELTD1(1), EMR2(7), GHRHR(1), GIPR(2), GLP1R(1), GLP2R(1), GPR64(1), LPHN1(3), LPHN2(6), LPHN3(9), SCTR(3)	19531472	46	38	45	12	14	6	5	13	8	0	0.112	0.999	1.000
249	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), EGFR(3), IGF1R(4), MYC(1), POLR2A(6), PPP2CA(2), PRKCA(2), RB1(3), TEP1(5), TNKS(5)	20109073	34	25	33	8	6	10	4	10	3	1	0.130	0.999	1.000
250	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(4), GLI2(3), GLI3(3), GSK3B(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), SHH(2), SUFU(1)	12250592	23	16	23	7	5	3	3	8	4	0	0.380	0.999	1.000
251	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	HRAS(4), MAPK1(1), MYC(1), NFKB1(3), PLCB1(3), PRKCA(2), RAF1(1), RELA(3), TNF(1)	11456384	19	15	17	6	6	4	5	4	0	0	0.320	0.999	1.000
252	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(3), EIF4A1(1), EIF4E(1), EIF4G1(4), EIF4G2(1), EIF4G3(6), GHR(1), IRS1(3), MAPK1(1), PDK2(1), PDPK1(1), PIK3R1(2), PRKCA(2)	18565129	27	21	26	6	7	4	0	10	6	0	0.319	0.999	1.000
253	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(8), EP300(7), LPL(1), NCOA1(1), NCOA2(2), PPARG(1), RXRA(2)	13659850	22	16	22	8	7	3	4	6	2	0	0.515	1.000	1.000
254	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(1), FUT3(2), ST3GAL3(1)	3754195	5	5	5	3	1	2	1	1	0	0	0.800	1.000	1.000
255	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(1), CSF1(1), HLA-DRA(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL1A(1), IL4(1), IL6(1), IL7(2), PDGFA(2), TGFB2(2), TNF(1)	9712960	17	14	17	8	6	2	2	3	4	0	0.707	1.000	1.000
256	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(1), DHRS1(1), DHRS7(1), DHRSX(5), ECHS1(1), EHHADH(5), ESCO1(5), ESCO2(1), GCDH(1), NAT6(1), SH3GLB1(1)	19176942	25	19	25	5	11	1	2	6	5	0	0.161	1.000	1.000
257	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(2), CBS(1), CTH(2), HEMK1(1), LCMT1(1), LCMT2(1), MARS2(1), MAT1A(3), METTL6(1), PAPSS2(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), SEPHS1(1), SEPHS2(3)	18352130	26	19	26	8	6	5	4	5	6	0	0.418	1.000	1.000
258	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT5(1), DDOST(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(1), MGAT3(1), MGAT4A(1), MGAT5(1), RPN1(1), RPN2(2), ST6GAL1(1)	14623681	22	17	22	6	6	6	1	8	1	0	0.342	1.000	1.000
259	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(1), ACTN2(2), BCAR1(3), CTNNA1(2), CTNNA2(5), PTK2(3), PXN(1), VCL(1)	12861649	18	12	18	7	7	2	1	3	5	0	0.638	1.000	1.000
260	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), PDE1B(1), PLCB1(3), PLCB2(1), PRL(1)	8190295	8	7	8	4	2	1	1	2	2	0	0.720	1.000	1.000
261	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(6), JAK2(1), JAK3(1), PIAS3(2), PTPRU(4), REG1A(1)	10106977	15	10	15	9	3	4	2	3	3	0	0.912	1.000	1.000
262	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(8), ABCB11(3), ABCB4(2), ABCC1(1), ABCC3(2), GSTP1(1)	10565247	17	11	17	8	7	4	1	3	2	0	0.721	1.000	1.000
263	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3D(1), ETV5(2), IL12A(1), IL12B(1), IL12RB2(1), JAK2(1), MAP2K6(1), STAT4(6), TYK2(2)	13663851	18	14	18	7	2	5	2	4	5	0	0.569	1.000	1.000
264	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(2), EPOR(1), GRIN1(3), HIF1A(2), JAK2(1), NFKB1(3), RELA(3), SOD2(1)	9324828	18	11	18	5	7	5	1	3	2	0	0.369	1.000	1.000
265	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(2), AKT1(3), CSF2RB(1), IGF1R(4), IL3RA(3), KIT(3), PIK3R1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	14562640	25	15	24	6	7	4	4	7	3	0	0.184	1.000	1.000
266	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(3), MAP3K1(5), NCOR2(7), RARA(1), RXRA(2), THRA(6)	12633639	27	16	27	7	12	3	1	8	3	0	0.197	1.000	1.000
267	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(2), MPO(3), PRDX1(1), TPO(5), TYR(2)	7090384	17	13	17	7	10	2	0	5	0	0	0.582	1.000	1.000
268	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(2), ACO1(1), ACO2(1), ACSS1(1), ACSS2(1), FH(3), MDH1(1), SUCLA2(1)	9166914	11	8	11	6	0	3	3	3	2	0	0.774	1.000	1.000
269	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(5), ITGAM(3), ITGB2(2), SELE(1)	7591645	12	11	11	6	7	1	1	2	1	0	0.626	1.000	1.000
270	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(3), RELA(3), TNFAIP3(1), TRAF6(2)	13318564	18	9	18	3	6	6	1	2	3	0	0.0673	1.000	1.000
271	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), FYN(1), LRP8(2), RELN(10), VLDLR(3)	10367157	18	12	18	8	4	4	3	6	1	0	0.759	1.000	1.000
272	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(7), CPT1A(1), LEPR(2), PRKAA2(5), PRKAG1(3)	10717499	18	16	18	6	4	4	4	5	0	1	0.469	1.000	1.000
273	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	GRB2(1), HRAS(4), KLK2(1), PIK3R1(2), PLCG1(1), RAF1(1), SHC1(3), SOS1(4)	12384863	17	16	15	8	8	1	4	0	4	0	0.763	1.000	1.000
274	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(3), RELA(3), RIPK1(1), TANK(1), TNFAIP3(1), TNFRSF1B(1), TRAF1(1), TRAF2(5)	16493720	25	16	25	5	9	7	3	4	2	0	0.0679	1.000	1.000
275	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), FDXR(2), SHMT1(1)	11790670	19	14	19	6	5	3	2	5	4	0	0.549	1.000	1.000
276	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR3(1), NCKAP1(1), NTRK1(9), RAC1(1), WASF1(2), WASF2(2), WASF3(1)	11278021	18	14	18	6	7	5	1	3	2	0	0.508	1.000	1.000
277	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(10), ASAH1(1), CERK(1), CREB1(1), DAG1(2), EPHB2(4), ITPKB(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK8IP3(4)	21030077	34	27	34	10	12	4	0	6	12	0	0.361	1.000	1.000
278	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(5), EGF(3), EGFR(3), GRB2(1), MET(4), PDGFRA(3), PRKCA(2), SH3GLB1(1), SH3GLB2(2)	14333269	25	20	25	8	8	3	4	10	0	0	0.363	1.000	1.000
279	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), CR2(2), HLA-DRA(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8)	11166290	20	19	19	9	9	3	2	5	1	0	0.704	1.000	1.000
280	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(1), HLA-A(1), KLRC1(1), PAK1(1), PIK3R1(2), RAC1(1), SYK(2), VAV1(3)	12096368	12	12	12	5	5	0	2	2	3	0	0.864	1.000	1.000
281	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATR(3), BRCA1(1), CDC25A(4), CDC25B(5), CDC34(1), CDKN1A(2), EP300(7), MDM2(1), MYT1(2), PRKDC(11), RPS6KA1(2), WEE1(1), YWHAQ(2)	25570873	42	27	42	8	16	7	3	8	8	0	0.0831	1.000	1.000
282	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(4), GLB1(2), HEXB(2), LCT(6)	10492890	16	13	16	6	9	2	0	4	1	0	0.459	1.000	1.000
283	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), HMGCR(1), LSS(2), MVK(1), NQO1(2), SQLE(1)	8059595	8	8	8	6	5	0	0	2	1	0	0.906	1.000	1.000
284	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGTR1(3), BDKRB2(2), NOS3(2)	7163967	11	8	11	8	4	4	0	2	1	0	0.923	1.000	1.000
285	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(3), DERA(1), FBP1(2), FBP2(1), H6PD(3), PFKL(2), PFKM(3), PFKP(3), PGM3(1), PRPS1L1(4), RBKS(2), TKT(2), TKTL2(4)	17897029	31	22	31	9	9	5	6	6	5	0	0.228	1.000	1.000
286	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(5), CNR2(1), DNMT1(3), MTNR1A(1), MTNR1B(2), PTGER2(2), PTGER4(1), PTGIR(3), TBXA2R(5)	8210197	24	14	24	8	14	4	1	2	3	0	0.134	1.000	1.000
287	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3)	17280021	27	19	27	6	9	7	2	6	3	0	0.151	1.000	1.000
288	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AGPS(1), ENPP2(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2A(1), PPAP2B(1)	17069299	27	18	27	8	8	3	0	7	9	0	0.446	1.000	1.000
289	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(3), PGAP1(1), PIGA(1), PIGB(2), PIGC(1), PIGG(3), PIGH(1), PIGK(1), PIGO(2), PIGQ(3), PIGT(1)	17504899	19	13	19	6	5	3	3	4	4	0	0.492	1.000	1.000
290	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), NFKB1(3), RELA(3), TNF(1), XDH(1)	7249489	9	4	9	4	3	4	1	1	0	0	0.590	1.000	1.000
291	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(10), CDH1(4), CREBBP(8), EP300(7), MAP3K7(2), TGFB2(2), TGFBR1(2)	18974735	35	29	35	10	7	4	5	7	12	0	0.445	1.000	1.000
292	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	GRB2(1), HRAS(4), IGF1R(4), IRS1(3), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(1), SHC1(3), SOS1(4)	16587587	24	18	22	7	10	1	6	3	4	0	0.363	1.000	1.000
293	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), PRF1(2)	9545885	14	9	14	6	2	4	0	7	1	0	0.783	1.000	1.000
294	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(4), GNE(1), GNPDA1(1), HEXB(2), HK1(2), HK2(4), HK3(4), PGM3(1), UAP1(1)	12453907	21	10	21	4	10	4	1	3	3	0	0.128	1.000	1.000
295	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), FUT1(1), FUT2(1), FUT3(2), FUT4(1), ST3GAL6(1), ST8SIA1(1)	11910347	20	13	20	8	6	4	2	6	1	1	0.676	1.000	1.000
296	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(3), FBP1(2), FBP2(1), H6PD(3), PFKM(3), PFKP(3), PGM3(1), PRPS1L1(4), RBKS(2), TKT(2)	15057169	24	18	24	7	6	4	5	6	3	0	0.321	1.000	1.000
297	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), RPL10A(3), RPL10L(2), RPL11(4), RPL12(1), RPL19(2), RPL28(1), RPL29(1), RPL3(1), RPL34(1), RPL35A(1), RPL36AL(1), RPL37(1), RPL3L(1), RPL6(2), RPL7(2), RPL8(1), RPS10(1), RPS11(2), RPS20(1), RPS5(1), RPS6(1), RPS9(1)	16796571	33	24	33	7	9	7	3	10	4	0	0.209	1.000	1.000
298	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6)	12333606	19	13	19	9	6	6	2	2	3	0	0.832	1.000	1.000
299	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(3), AOC3(1), CES1(3), DDHD1(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1)	18634387	21	16	21	5	3	2	4	8	4	0	0.339	1.000	1.000
300	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(7), ACACB(3), FASN(5)	11469712	15	11	15	8	3	1	2	7	1	1	0.885	1.000	1.000
301	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), HMGCR(1), HMGCS1(1), LSS(2), MVK(1), SQLE(1)	9625901	7	7	7	8	4	0	0	2	1	0	0.991	1.000	1.000
302	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(2), GOSR1(2), SNAP25(1), STX16(3), STX7(1), STX8(2), USE1(1), VAMP1(1), VAMP5(1), VAMP7(2), VTI1A(1), YKT6(1)	12249243	19	11	19	7	9	1	2	3	4	0	0.624	1.000	1.000
303	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG5(2), ATG7(1), BECN1(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), PIK3C3(1), PIK3R4(2), PRKAA2(5), ULK1(1), ULK2(1), ULK3(2)	15555851	24	18	24	9	7	3	5	6	3	0	0.625	1.000	1.000
304	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(1), DHFR(2), MTHFD2(1), POLD1(3), POLG(2), SRM(1)	9176002	11	5	11	7	4	4	2	0	1	0	0.839	1.000	1.000
305	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), EPX(4), GOT1(2), GOT2(1), HPD(2), LPO(2), MAOA(2), MAOB(2), MPO(3), PRDX1(1), TPO(5)	16042176	32	25	32	10	11	6	1	11	3	0	0.388	1.000	1.000
306	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), OPRK1(1), POLR2A(6), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	9460940	15	6	15	5	7	4	1	3	0	0	0.357	1.000	1.000
307	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), ARHGDIB(1), BIRC2(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), DFFA(4), LMNA(4), LMNB2(2), PRF1(2)	14261144	21	11	21	4	5	8	0	6	2	0	0.151	1.000	1.000
308	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), AOC2(3), AOC3(1), AOX1(2), ASMT(2), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), ECHS1(1), EHHADH(5), GCDH(1), KMO(2), KYNU(3), MAOA(2), MAOB(2), SDS(1), TDO2(1), TPH1(1), WARS(1), WARS2(2)	40556129	81	60	80	17	27	9	11	22	12	0	0.0433	1.000	1.000
309	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(1), CASP10(1), CASP8(1), CASP9(1), DFFA(4), PRF1(2), SCAP(2), SREBF1(2), SREBF2(2)	13435706	18	8	18	6	4	5	0	8	1	0	0.517	1.000	1.000
310	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(3), ALG12(1), ALG13(1), ALG14(2), ALG5(1), ALG8(1), ALG9(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), DDOST(1), DPM1(2), FUT8(2), GANAB(3), MAN1A1(2), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT3(1), MGAT4A(1), MGAT5(1), MGAT5B(2), RFT1(2), RPN1(1), RPN2(2), ST6GAL1(1)	30971637	42	26	42	9	9	8	3	11	11	0	0.208	1.000	1.000
311	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(10), AXIN1(1), BTRC(3), CREBBP(8), DVL1(1), FZD1(2), GSK3B(1), HDAC1(1), MAP3K7(2), MYC(1), NLK(1), PPARD(4), PPP2CA(2), TLE1(4), WIF1(2), WNT1(1)	20453145	44	32	44	12	11	7	5	5	16	0	0.238	1.000	1.000
312	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), MAP2K4(4), MAP3K1(5), MAPK1(1), NFKB1(3), NSMAF(4), RAF1(1), RELA(3), RIPK1(1), TNFRSF1A(1), TRAF2(5)	15053753	29	17	29	9	9	9	3	7	1	0	0.264	1.000	1.000
313	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(3), DLAT(1), DLD(2), FH(3), IDH3A(1), IDH3B(1), MDH1(1), PC(2), PDHA1(1), PDHA2(4), PDHX(1), PDK1(2), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(3), SDHB(2), SDHC(2), SUCLA2(1)	20860720	36	24	35	9	3	11	3	10	9	0	0.128	1.000	1.000
314	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(3), FBP1(2), FBP2(1), GOT1(2), GOT2(1), MDH1(1), ME1(3), ME3(1), PGK2(2), PKLR(1), TKT(2), TKTL2(4)	14830288	23	14	23	5	6	5	4	5	3	0	0.101	1.000	1.000
315	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(1), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), GLUD1(2), NAGS(1), ODC1(1), OTC(1), PYCR1(2)	12840380	20	17	20	9	8	3	1	6	2	0	0.724	1.000	1.000
316	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	AKT1(3), CALM1(1), GNAS(2), GNB1(1), GNGT1(1), NFKB1(3), NOS3(2), NPPA(1), PIK3R1(2), RELA(3), SYT1(1)	11472699	20	15	19	7	4	7	1	6	2	0	0.633	1.000	1.000
317	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(4), GLB1(2), HEXB(2), HGSNAT(1), HPSE(3), HYAL2(2), LCT(6), SPAM1(3)	14978624	25	16	25	9	13	5	0	5	2	0	0.443	1.000	1.000
318	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(2), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(1), EDNRA(1), HPGD(1), HSD11B1(1), PLA2G4A(4), PRL(1), PTGER2(2), PTGER4(1), PTGIR(3), PTGIS(2), PTGS1(2), PTGS2(5), SCGB1A1(2), TBXAS1(2)	15290187	35	23	35	11	11	7	2	6	9	0	0.300	1.000	1.000
319	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH5A1(1), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HMGCL(1), L2HGDH(1), OXCT1(5), PDHA1(1), PDHA2(4), SDHB(2), SDS(1)	19013619	51	38	48	15	16	11	6	10	8	0	0.157	1.000	1.000
320	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(3), IKBKB(1), IL4(1), MAP3K1(5), MAP3K5(2), MAP4K5(1), NFKB1(3), RELA(3), TRAF2(5)	14232233	24	13	24	5	9	7	1	5	2	0	0.117	1.000	1.000
321	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), CP(5), CPOX(1), EPRS(4), HMBS(1), HMOX1(2), HMOX2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1)	20247639	27	21	27	7	10	4	1	9	3	0	0.299	1.000	1.000
322	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(3), BCR(2), GRB2(1), HRAS(4), JAK2(1), MAP2K4(4), MAP3K1(5), MYC(1), PIK3R1(2), RAF1(1), SOS1(4), STAT1(1), STAT5B(2)	19125791	31	23	28	8	8	7	5	6	5	0	0.141	1.000	1.000
323	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATR(3), BRCA1(1), BRCA2(8), FANCA(2), FANCC(1), FANCD2(2), FANCF(1), FANCG(1), HUS1(1), RAD17(2), RAD50(1), RAD51(1), RAD9A(1)	27409493	25	21	25	9	4	3	1	9	8	0	0.886	1.000	1.000
324	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	APC(10), ATF2(3), AXIN1(1), BMP10(1), BMP2(2), BMP4(1), BMP5(4), BMP7(3), BMPR1A(2), BMPR2(3), CHRD(1), DVL1(1), FZD1(2), GATA4(1), GSK3B(1), MAP3K7(2), MEF2C(3), NPPA(1), RFC1(5), TGFB2(2), TGFBR1(2), TGFBR3(1), WNT1(1)	25623623	53	35	53	14	11	10	9	8	15	0	0.141	1.000	1.000
325	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(1), IL4(1), TGFB2(2), TGFBR1(2), TGFBR3(1), TOB1(1), TOB2(1)	7805360	11	9	11	7	1	3	4	2	1	0	0.868	1.000	1.000
326	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), CHRNG(1), MUSK(3), PIK3R1(2), PTK2(3)	10312432	12	9	11	6	5	4	0	2	1	0	0.661	1.000	1.000
327	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(1), AKT3(1), CDKN1A(2), GRB2(1), HRAS(4), NTRK1(9), PIK3CD(5), SHC1(3), SOS1(4)	10183039	33	27	30	12	16	6	3	2	6	0	0.335	1.000	1.000
328	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX5(1), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2J2(1), CYP2U1(2), CYP4A11(1), CYP4A22(2), CYP4F2(2), CYP4F3(2), DHRS4(1), GPX2(2), GPX6(1), LTC4S(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2)	28592782	59	40	59	11	18	11	6	14	10	0	0.0122	1.000	1.000
329	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(4), EPHB1(8), FYN(1), ITGA1(2), L1CAM(6), LYN(2), SELP(4)	11624514	28	22	28	11	7	4	4	9	4	0	0.586	1.000	1.000
330	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1(1), CSF1R(5), E2F1(3), ETS1(1), HDAC2(1), HDAC5(4), HRAS(4), NCOR2(7), RBL1(2), RBL2(2), SIN3A(1), SIN3B(2)	18770392	33	21	31	9	13	5	7	3	5	0	0.142	1.000	1.000
331	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CAMK1(3), CAMK1G(2), FPR1(3), GNB1(1), GNGT1(1), HRAS(4), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAPK1(1), NCF1(1), NCF2(3), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(1), PLCB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAC1(1), RAF1(1), RELA(3), SYT1(1)	28027341	52	34	50	14	14	9	7	13	9	0	0.186	1.000	1.000
332	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C1(1), AKR1C3(1), AKR1C4(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A43(1), CYP3A7(1), EPHX1(3), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), MGST1(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3)	42399490	79	55	79	15	20	9	11	29	10	0	0.0210	1.000	1.000
333	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(1), CALM1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYNJ1(3), SYNJ2(3), SYT1(1)	16003282	22	17	22	8	5	3	2	8	4	0	0.627	1.000	1.000
334	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AOC2(3), AOC3(1), CNDP1(3), DPYD(3), DPYS(2), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HIBCH(1), SRM(1)	19895388	40	33	40	13	15	7	5	7	6	0	0.322	1.000	1.000
335	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(2), GPX2(2), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), MGST1(1)	12674012	13	10	13	5	4	3	1	5	0	0	0.590	1.000	1.000
336	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), GNAS(2), PLCE1(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RAP2B(1)	10870168	16	13	16	9	4	1	1	9	1	0	0.939	1.000	1.000
337	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), EGR3(1), MAP3K1(5), MYC(1), NFATC1(2), NFATC2(2), NFKB1(3), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RELA(3), SYT1(1)	20608502	32	17	32	9	9	7	3	9	4	0	0.202	1.000	1.000
338	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(3), APAF1(2), CASP9(1), EIF2S1(1), PRKCA(2), PTK2(3), PXN(1), STAT1(1), TLN1(4)	15002814	18	13	17	8	4	4	1	6	3	0	0.734	1.000	1.000
339	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), GRB2(1), HRAS(4), IL3RA(3), JAK2(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2)	13052662	20	15	18	8	7	4	5	0	4	0	0.475	1.000	1.000
340	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1(3), CAMK1G(2), CAMK2A(1), CAMK2D(2), CAMK4(4), HDAC5(4), MEF2A(1), MEF2C(3), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYT1(1)	14817884	30	18	30	10	11	4	1	9	5	0	0.467	1.000	1.000
341	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(10), AXIN1(1), CREBBP(8), DVL1(1), EP300(7), FZD1(2), GSK3B(1), HDAC1(1), LEF1(2), PITX2(3), TRRAP(5), WNT1(1)	23298491	42	31	42	14	14	5	6	6	11	0	0.331	1.000	1.000
342	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD2(1), GRM1(9), PLCB1(3), PPP1CA(1), PPP2CA(2), PPP3CA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	11835042	25	19	24	10	8	5	1	7	4	0	0.657	1.000	1.000
343	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(2), CREB1(1), EP300(7), HIF1A(2), NOS3(2), P4HB(1), VHL(3)	12480708	20	12	20	8	10	4	1	3	2	0	0.586	1.000	1.000
344	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADSB(3), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(3), DPYS(2), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), SDS(1)	21433687	46	36	45	14	16	8	7	7	8	0	0.233	1.000	1.000
345	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	BMPR1B(2), CEBPB(1), EGR1(3), FSHR(2), GJA4(2), INHA(1), LHCGR(1), MLH1(2), MSH5(1), NCOR1(8), NRIP1(4), PGR(2), PRLR(1), PTGER2(2), VDR(2), ZP2(3)	20943798	37	27	37	12	9	6	4	4	14	0	0.535	1.000	1.000
346	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(3), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), NOS1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), SYT1(1)	18780418	47	33	47	17	17	6	1	18	5	0	0.400	1.000	1.000
347	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(5), BRCA1(1), CDKN1A(2), MDM2(1), NFKB1(3), RAD50(1), RAD51(1), RBBP8(1), RELA(3), TP73(2)	16809984	20	8	20	5	6	4	3	4	3	0	0.376	1.000	1.000
348	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(3), EGFR(3), HGS(2), TF(1), TFRC(1)	9503241	14	10	14	8	1	1	3	8	1	0	0.949	1.000	1.000
349	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(1), CALM1(1), FCER1A(1), GRB2(1), HRAS(4), LYN(2), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAPK1(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(2), PIK3R1(2), PLA2G4A(4), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(1), SHC1(3), SOS1(4), SYK(2), SYT1(1), VAV1(3)	30066280	58	41	56	16	20	8	5	14	11	0	0.225	1.000	1.000
350	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(2), GPX2(2), GPX6(1), GSR(1), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), MGST1(1), OPLAH(2)	15582803	17	12	17	7	6	4	1	5	1	0	0.565	1.000	1.000
351	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOC(3), FBP1(2), FBP2(1), GCK(4), GMDS(1), GMPPB(3), HK1(2), HK2(4), HK3(4), KHK(1), MPI(1), PFKFB1(2), PFKFB4(1), PFKM(3), PFKP(3), PMM1(1)	17487806	36	22	36	13	16	2	5	8	5	0	0.345	1.000	1.000
352	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(2), ARSD(1), ARSE(2), ASAH1(1), GAL3ST1(2), GALC(1), GLB1(2), LCT(6), NEU1(1), NEU2(2), NEU4(2), PPAP2A(1), PPAP2B(1), SMPD2(2), SPTLC1(1), SPTLC2(1)	17724889	28	23	28	10	12	3	3	7	3	0	0.412	1.000	1.000
353	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA1(1), CA12(1), CA14(2), CA2(3), CA3(1), CA4(2), CA5A(1), CA6(1), CA8(4), CA9(2), CPS1(4), CTH(2), GLUD1(2), GLUL(1), HAL(2)	14022589	30	26	30	10	8	6	1	10	5	0	0.499	1.000	1.000
354	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(8), DUSP1(1), EP300(7), IKBKB(1), MAP2K3(1), MAP2K6(1), MAP3K7(2), NFKB1(3), RELA(3), TGFBR1(2), TLR2(2), TNF(1)	21833709	32	22	32	9	10	7	5	7	3	0	0.260	1.000	1.000
355	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(3), APC(10), ASAH1(1), CAV3(1), DAG1(2), DLG4(3), EPHB2(4), GNAI1(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PITX2(3), PTX3(1), RAC1(1), RHO(1), RYR1(20)	33703560	74	56	73	19	33	7	4	13	17	0	0.0639	1.000	1.000
356	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(1), ACO2(1), CS(3), DLD(2), FH(3), IDH3A(1), IDH3B(1), MDH1(1), PC(2), SDHA(3), SDHB(2), SUCLA2(1)	14536055	21	12	21	7	3	5	4	5	4	0	0.371	1.000	1.000
357	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPOR(1), GRB2(1), HRAS(4), JAK2(1), PLCG1(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2)	15744634	18	15	16	9	8	3	4	0	3	0	0.727	1.000	1.000
358	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(2), AKT1(3), CAMK2A(1), CAMK2D(2), CREB1(1), GNAS(2), GRB2(1), HRAS(4), MAPK1(1), PIK3R1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), RAC1(1), RPS6KA1(2), RPS6KA5(3), SOS1(4)	19842557	38	27	35	12	12	5	6	11	4	0	0.402	1.000	1.000
359	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(3), AKT2(1), AKT3(1), ANKRD6(2), APC(10), AXIN1(1), AXIN2(5), DACT1(4), DKK1(3), DKK2(2), DVL1(1), GSK3A(3), GSK3B(1), LRP1(12), MVP(2), NKD2(1), PTPRA(5), WIF1(2)	28405081	59	37	58	14	17	14	6	8	14	0	0.0327	1.000	1.000
360	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(3), ACADVL(1), ACAT1(2), ACAT2(1), ACOX1(2), ACOX3(1), ACSL1(3), ACSL5(1), ACSL6(3), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), CYP4A11(1), CYP4A22(2), ECHS1(1), EHHADH(5), GCDH(1), HADH(3), HADHB(1), HSD17B4(3)	36136855	64	42	63	15	24	8	8	12	12	0	0.0418	1.000	1.000
361	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BIRC2(1), CASP10(1), CASP8(1), CASP9(1), CFLAR(2), DFFA(4), LMNA(4), NFKB1(3), RELA(3), RIPK1(1), SPTAN1(2), TNFRSF10A(1), TNFRSF10B(2), TNFSF12(1), TRAF2(5)	24522172	34	19	34	8	9	11	2	10	2	0	0.154	1.000	1.000
362	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(3), AKT2(1), AKT3(1), DAG1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PDK1(2), PHKA2(2), PIK3CB(3), PITX2(3), PLD1(3), PLD2(2), VN1R1(2)	33003130	51	37	50	10	13	13	3	14	8	0	0.0309	1.000	1.000
363	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	GRB2(1), HRAS(4), JAK1(6), MAP2K4(4), MAP3K1(5), PDGFA(2), PDGFRA(3), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6)	24057236	46	32	44	15	16	8	6	9	7	0	0.300	1.000	1.000
364	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(5), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GCNT1(2), ST3GAL1(2), WBSCR17(2)	10631557	20	13	20	9	9	2	0	7	2	0	0.763	1.000	1.000
365	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), CREB1(1), DUSP1(1), EEF2K(5), EIF4E(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K10(4), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), NFKB1(3), TRAF6(2)	24427549	37	21	36	12	14	8	2	6	7	0	0.327	1.000	1.000
366	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(3), ALAS2(1), BLVRB(1), COX15(2), CP(5), CPOX(1), EARS2(1), EPRS(4), FTMT(2), HMBS(1), HMOX1(2), HMOX2(1), MMAB(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3)	31098922	53	36	53	15	17	7	4	18	7	0	0.282	1.000	1.000
367	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOC(3), FBP1(2), FBP2(1), FUK(1), GMDS(1), GMPPB(3), HK1(2), HK2(4), HK3(4), KHK(1), LHPP(1), MPI(1), MTMR2(4), MTMR6(1), PFKFB1(2), PFKFB4(1), PFKL(2), PFKM(3), PFKP(3), PGM2(3), PMM1(1), RDH12(1), TSTA3(5)	27168496	50	30	50	17	17	4	8	12	9	0	0.267	1.000	1.000
368	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), AOX1(2), DBH(5), FAH(1), GOT1(2), GOT2(1), HGD(1), HPD(2), MAOA(2), MAOB(2), PNMT(1), TPO(5), TYR(2)	23251996	41	36	41	13	14	7	3	10	7	0	0.306	1.000	1.000
369	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CLCA1(1), CLCA2(2), CLCA4(2), CNGA3(1), CNGA4(4), CNGB1(1), GNAL(3), GUCA1A(1), PDE1C(3), PRKACA(2), PRKG1(1), PRKX(2)	22469928	31	27	31	11	10	5	4	5	7	0	0.361	1.000	1.000
370	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), CD36(1), CITED2(1), CPT1B(2), CREBBP(8), DUSP1(1), EHHADH(5), EP300(7), HSD17B4(3), LPL(1), MAPK1(1), ME1(3), MRPL11(1), MYC(1), NCOA1(1), NCOR1(8), NCOR2(7), NR1H3(1), NR2F1(1), NRIP1(4), PDGFA(2), PIK3R1(2), PPARA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PTGS2(5), RB1(3), RELA(3), RXRA(2), SP1(2), STAT5B(2), TNF(1)	44928749	92	58	92	21	27	18	9	16	21	1	0.0171	1.000	1.000
371	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), ATP7A(2), ATP7B(2), COX7A1(2), COX7C(1), NDUFA10(2), NDUFA5(1), NDUFB7(1), NDUFS2(2), NDUFV1(1), SDHA(3), SDHB(2), SHMT1(1), UQCRC1(2)	28155279	41	28	41	11	8	12	5	11	5	0	0.167	1.000	1.000
372	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), CASP8(1), DFFA(4), LMNA(4), LMNB2(2), MADD(1), MAP2K4(4), MAP3K1(5), MAP3K7(2), PAK1(1), PAK2(2), PRKDC(11), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(1), TRAF2(5)	28392344	51	32	51	14	18	12	3	10	7	1	0.215	1.000	1.000
373	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH5A1(1), ALDH7A1(2), DDHD1(5), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HADH(3), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), ILVBL(3), L2HGDH(1), OXCT1(5), PDHA1(1), PDHA2(4), RDH12(1)	29827275	62	46	60	16	21	10	7	14	10	0	0.0789	1.000	1.000
374	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(1), CD3D(1), FYN(1), GRB2(1), HRAS(4), MAP2K4(4), MAP3K1(5), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PIK3R1(2), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), PTPN7(4), RAC1(1), RAF1(1), RASA1(1), RELA(3), SHC1(3), SOS1(4), SYT1(1), VAV1(3), ZAP70(6)	33572775	63	37	61	20	23	10	8	13	9	0	0.249	1.000	1.000
375	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(3), BCR(2), GRB2(1), HRAS(4), LYN(2), MAP3K1(5), MAPK1(1), MAPK8IP3(4), PAPPA(3), RAC1(1), RPS6KA1(2), SHC1(3), SOS1(4), SYK(2), VAV1(3), VAV2(3), VAV3(4)	23509829	47	35	45	17	17	7	8	9	6	0	0.400	1.000	1.000
376	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(3), APC(10), AR(2), ASAH1(1), CCL15(1), DAG1(2), EGFR(3), GNA11(1), GNAI1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PHKA2(2), PIK3CD(5), PIK3R1(2), PITX2(3), PTX3(1), RAF1(1)	36443517	62	50	61	19	20	8	3	14	17	0	0.311	1.000	1.000
377	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC2(4), ANAPC4(1), ANAPC5(3), ANAPC7(1), BTRC(3), CDC16(1), CDC20(2), CDC23(3), CDC27(2), CUL1(2), CUL2(4), CUL3(5), FBXW11(2), FZR1(4), ITCH(2), SMURF1(1), SMURF2(1), TCEB2(1), UBA1(2), UBE2C(1), VHL(3), WWP1(3), WWP2(1)	29561326	56	35	55	12	10	9	12	14	11	0	0.0685	1.000	1.000
378	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), EPX(4), ESCO1(5), ESCO2(1), GOT1(2), GOT2(1), HPD(2), LPO(2), MAOA(2), MAOB(2), MPO(3), NAT6(1), SH3GLB1(1), TPO(5)	25108403	39	31	39	13	12	6	3	12	6	0	0.537	1.000	1.000
379	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(1), AKT3(1), ARHGEF11(2), DLG4(3), GNA13(2), LPA(5), MAP2K4(4), MAP3K1(5), MAP3K5(2), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PDK1(2), PHKA2(2), PI3(1), PIK3CB(3), PLD1(3), PLD2(2), PTK2(3), RDX(1), ROCK1(5), ROCK2(1), SERPINA4(1), TBXA2R(5)	36201850	64	42	62	17	18	13	5	15	13	0	0.125	1.000	1.000
380	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(2), BCL2L11(1), BIRC2(1), BIRC5(2), CASP1(2), CASP10(1), CASP8(1), CASP9(1), DFFA(4), FAS(1), FASLG(1), HELLS(1), IKBKB(1), IRF2(1), IRF3(1), IRF4(4), IRF5(1), IRF6(3), MAP2K4(4), MAP3K1(5), MDM2(1), MYC(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PRF1(2), RELA(3), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(7), TP73(2), TRAF1(1), TRAF2(5)	41514315	72	44	72	19	19	15	4	23	11	0	0.153	1.000	1.000
381	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(7), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ECHS1(1), EHHADH(5), LDHB(1), LDHC(1), MUT(3), SDS(1), SUCLA2(1)	24448002	41	27	40	12	11	5	7	11	6	1	0.335	1.000	1.000
382	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), FUCA1(1), FUCA2(1), GALNS(4), GLB1(2), HEXB(2), HGSNAT(1), HPSE(3), HYAL2(2), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2), SPAM1(3)	25214885	43	27	43	14	22	6	1	7	7	0	0.302	1.000	1.000
383	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(2), BIRC2(1), CASP8(1), CASP9(1), FAS(1), FASLG(1), MAP2K4(4), MAP3K1(5), MCL1(1), MDM2(1), MYC(1), NFKB1(3), PARP1(2), PRF1(2), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF2(5)	26845760	39	23	39	14	9	12	2	12	4	0	0.466	1.000	1.000
384	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(2), ASAH1(1), B4GALT6(3), CERK(1), DEGS1(1), DEGS2(2), ENPP7(3), GAL3ST1(2), GALC(1), GLB1(2), LCT(6), NEU1(1), NEU2(2), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(1), SMPD2(2), SMPD3(1), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC1(1), SPTLC2(1)	26097497	41	24	41	13	22	5	4	5	5	0	0.158	1.000	1.000
385	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), CHIT1(1), CMAS(1), CTBS(1), CYB5R1(1), GFPT2(2), GNE(1), GNPDA1(1), GNPNAT1(1), HEXB(2), HK1(2), HK2(4), HK3(4), LHPP(1), MTMR2(4), MTMR6(1), NAGK(1), NANS(1), PGM3(1), UAP1(1)	21093853	32	17	32	10	9	6	3	9	5	0	0.400	1.000	1.000
386	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPPL1(1), ITPKB(2), OCRL(3), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3CB(3), PIK3CG(7), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCG1(1), PLCG2(3)	31250630	49	30	49	11	16	13	4	11	5	0	0.0552	1.000	1.000
387	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), FLT1(5), FLT4(4), HIF1A(2), HRAS(4), KDR(7), NOS3(2), PIK3R1(2), PLCG1(1), PRKCA(2), PTK2(3), PXN(1), SHC1(3), VHL(3)	23384284	46	29	44	16	17	7	5	6	10	1	0.488	1.000	1.000
388	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR3(1), AKT1(3), ANGPTL2(1), DAG1(2), DGKA(1), ETFA(1), ITGA9(4), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), MAPK1(1), NR1I3(2), PAK1(1), PDE3A(2), PDE3B(3), PI3(1), PIK3C2G(1), PIK3CD(5), PIK3R1(2), PSME1(1), RIPK3(1)	34160749	53	41	52	14	16	10	3	12	12	0	0.226	1.000	1.000
389	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), AOX1(2), BCAT1(1), BCKDHA(1), ECHS1(1), EHHADH(5), HADHB(1), HMGCL(1), IVD(2), MCCC1(1), MUT(3), OXCT1(5), SDS(1)	26574738	49	35	47	16	14	7	8	12	8	0	0.409	1.000	1.000
390	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4), F10(3), F11(4), F12(1), F2(2), F2R(2), F5(5), F8(1), FGA(5), FGB(2), FGG(1), KLKB1(2), PROC(3), PROS1(3), SERPINC1(2), SERPING1(2)	32528253	56	43	56	21	19	10	2	16	9	0	0.642	1.000	1.000
391	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(2), ESR1(2), NR1D1(3), NR1D2(2), NR1H3(1), NR1I2(2), NR1I3(2), NR2E1(1), NR2F1(1), NR2F2(1), NR4A1(1), NR4A2(2), NR5A2(1), PGR(2), PPARA(2), PPARD(4), PPARG(1), RARA(1), RARB(3), RARG(1), ROR1(1), RORA(1), RXRA(2), RXRB(2), RXRG(2), THRA(6), VDR(2)	30663004	54	37	53	13	27	8	6	8	5	0	0.0424	1.000	1.000
392	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(1), GRB2(1), HRAS(4), MAP2K3(1), MAP2K4(4), MAP3K1(5), MAPK1(1), PAK1(1), PLCG1(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYT1(1)	20926316	34	24	32	12	14	5	5	5	5	0	0.426	1.000	1.000
393	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), IKBKB(1), IRAK1(1), LY96(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP3K7(2), NFKB1(3), PPARA(2), RELA(3), TIRAP(1), TLR10(1), TLR2(2), TLR4(2), TLR7(3), TLR9(1), TRAF6(2)	26685518	38	21	37	13	15	8	2	9	4	0	0.295	1.000	1.000
394	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(2), AASDHPPT(1), AASS(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), BBOX1(2), DOT1L(4), ECHS1(1), EHHADH(5), EHMT1(1), EHMT2(3), GCDH(1), PLOD1(2), PLOD3(3), SDS(1), SHMT1(1), SHMT2(1)	27228611	48	36	47	14	14	6	7	11	10	0	0.249	1.000	1.000
395	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(1), CYP4F2(2), CYP4F3(2), EPX(4), LPO(2), MPO(3), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2), TPO(5)	20464935	43	29	43	15	17	8	1	12	5	0	0.336	1.000	1.000
396	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CD4(1), CD8A(1), CD8B(2), CIITA(3), CREB1(1), CTSS(1), HLA-A(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), HSP90AA1(3), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), KIR3DL1(2), KLRC1(1), LGMN(1), NFYA(1), NFYC(3), PDIA3(1), PSME1(1), RFX5(1), RFXAP(1), TAP1(3), TAP2(1)	34126564	50	34	50	13	16	8	7	10	9	0	0.104	1.000	1.000
397	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), ARSD(1), ARSE(2), CARM1(2), CYP11B1(1), CYP11B2(2), CYP19A1(2), HEMK1(1), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD17B7(2), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), STS(1), SULT1E1(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3)	37005051	62	45	61	17	12	11	8	20	11	0	0.200	1.000	1.000
398	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(2), ACAA2(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ALDH7A1(2), AOX1(2), BCAT1(1), BCAT2(1), BCKDHA(1), DBT(1), DLD(2), ECHS1(1), EHHADH(5), HADH(3), HADHB(1), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), IVD(2), MCCC1(1), MUT(3), OXCT1(5)	31705200	55	40	54	17	17	10	6	13	9	0	0.304	1.000	1.000
399	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(2), ALAS1(3), ALAS2(1), AMT(1), AOC2(3), AOC3(1), BHMT(2), CBS(1), CHDH(4), CTH(2), DAO(1), DLD(2), DMGDH(1), GARS(1), GCAT(1), GLDC(3), MAOA(2), MAOB(2), PHGDH(1), PIPOX(2), PISD(1), PSAT1(1), RDH12(1), SARDH(6), SARS(2), SDS(1), SHMT1(1), SHMT2(1), TARS(3), TARS2(3)	31223027	57	34	57	17	21	13	0	11	11	1	0.264	1.000	1.000
400	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), CABIN1(1), CALM1(1), CAMK1(3), CAMK1G(2), HDAC5(4), IGF1R(4), MAP2K6(1), MEF2A(1), MEF2C(3), MEF2D(1), NFATC1(2), NFATC2(2), PIK3R1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYT1(1)	23901312	36	24	35	14	11	5	4	11	5	0	0.569	1.000	1.000
401	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CARM1(2), CREBBP(8), EP300(7), ERCC3(1), ESR1(2), GRIP1(5), GTF2E1(1), HDAC1(1), HDAC2(1), HDAC3(2), HDAC4(3), HDAC5(4), HDAC6(4), MEF2C(3), NCOR2(7), NRIP1(4), PELP1(2), POLR2A(6)	33447832	64	37	64	23	19	14	9	12	10	0	0.362	1.000	1.000
402	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(6), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(2), G6PC(1), GAA(1), GANAB(3), GBE1(2), GCK(4), GYS1(4), HK1(2), HK2(4), HK3(4), MGAM(4), PGM3(1), PYGB(4), PYGL(4), PYGM(1), RNPC3(1), SI(6), UGDH(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1)	41985061	74	45	73	18	20	13	11	16	14	0	0.0897	1.000	1.000
403	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(2), ATR(3), BAI1(7), CASP8(1), CASP9(1), CCNB2(1), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN1A(2), CDKN2A(1), EI24(1), FAS(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(1), PERP(1), PPM1D(1), RCHY1(2), RFWD2(1), RRM2(1), SERPINB5(4), SESN1(2), SESN2(4), SESN3(3), STEAP3(1), THBS1(3), TNFRSF10B(2), TP73(2), TSC2(7)	42212998	63	44	63	17	25	6	5	18	9	0	0.169	1.000	1.000
404	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(1), CREB1(1), CREBBP(8), DAG1(2), EGR1(3), EGR3(1), FRS2(1), MAP1B(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK8IP3(4), NTRK1(9), OPN1LW(1), PIK3C2G(1), PIK3CD(5), PIK3R1(2), PTPN11(1), SHC1(3), TERF2IP(1)	34819866	58	41	57	21	27	9	1	11	10	0	0.401	1.000	1.000
405	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(2), CARS(4), CARS2(2), DARS2(1), EARS2(1), EPRS(4), FARS2(2), FARSB(2), GARS(1), HARS(1), IARS(2), IARS2(1), KARS(2), LARS(3), LARS2(2), MARS2(1), NARS2(1), PARS2(3), QARS(1), RARS2(1), SARS(2), TARS(3), TARS2(3), VARS(4), VARS2(4), WARS(1), WARS2(2), YARS(3), YARS2(3)	40001155	63	40	63	14	25	11	6	14	7	0	0.0812	1.000	1.000
406	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(2), ALAS1(3), ALAS2(1), AMT(1), AOC2(3), AOC3(1), BHMT(2), CBS(1), CHDH(4), CPT1B(2), CTH(2), DAO(1), DLD(2), DMGDH(1), GARS(1), GCAT(1), GLDC(3), MAOA(2), MAOB(2), PISD(1), PLCB2(1), PLCG1(1), PLCG2(3), SARDH(6), SARS(2), SHMT1(1), SHMT2(1), TARS(3)	30685068	55	35	55	16	17	10	2	13	12	1	0.293	1.000	1.000
407	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(7), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), DLAT(1), DLD(2), HAGH(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(1), ME3(1), PC(2), PDHA1(1), PDHA2(4), PKLR(1)	27220442	43	28	41	10	9	8	7	11	7	1	0.108	1.000	1.000
408	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), GK(1), GLB1(2), LCT(6), LIPC(1), LIPG(5), LPL(1), PNLIP(4), PNLIPRP1(1), PPAP2A(1), PPAP2B(1)	35279292	65	43	64	24	22	8	7	16	12	0	0.417	1.000	1.000
409	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BCL2A1(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), CD40(1), CD40LG(1), DAXX(2), DFFA(4), FAS(1), FASLG(1), IKBKE(1), MCL1(1), NFKB1(3), NTRK1(9), PTPN13(1), RIPK1(1), TFG(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF2(5), TRAF6(2)	31959497	46	27	46	10	18	13	2	8	5	0	0.0394	1.000	1.000
410	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(2), B4GALT2(2), FBP2(1), G6PC(1), GAA(1), GALK1(1), GALK2(1), GALT(1), GANAB(3), GCK(4), GLB1(2), HK1(2), HK2(4), HK3(4), LCT(6), MGAM(4), PFKM(3), PFKP(3), PGM3(1)	23846052	46	26	46	17	24	5	3	9	5	0	0.339	1.000	1.000
411	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(3), ATP8A1(1), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CXCR6(1), EDNRA(1), FPR1(3), FSHR(2), GALT(1), GHSR(1), GNRHR(4), GRPR(1), LHCGR(1), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), TACR1(2), TACR2(1), TACR3(2), TRHR(1), TSHR(1)	38530637	91	58	90	27	39	15	4	26	7	0	0.0446	1.000	1.000
412	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(3), AKT2(1), AKT3(1), ASAH1(1), DAG1(2), DRD2(1), EGFR(3), EPHB2(4), GRB2(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(3), PITX2(3), PLCB1(3), PLCB2(1), PLCB4(8), RAF1(1), SHC1(3), SOS1(4), SOS2(1), STAT3(6), TERF2IP(1)	41963910	75	58	74	24	20	16	4	24	11	0	0.342	1.000	1.000
413	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(3), ATF2(3), DLD(2), DUSP8(3), GAB1(1), GCK(4), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K11(1), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K9(4), NFATC3(1), PAPPA(3), SHC1(3), TRAF6(2)	36490119	61	34	60	17	20	15	3	10	13	0	0.122	1.000	1.000
414	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(2), EEF1A2(2), EEF1G(1), EEF2(2), EEF2K(5), EIF2AK3(4), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF4A1(1), EIF4E(1), EIF4G1(4), EIF4G3(6), EIF5(2), EIF5A(2), EIF5B(1), ETF1(2), PABPC3(1), SLC35A4(1)	32254089	42	31	42	14	12	3	4	12	11	0	0.510	1.000	1.000
415	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(2), ACOX1(2), ACOX2(2), ACOX3(1), ACSL1(3), ACSL5(1), ACSL6(3), ADIPOQ(1), APOA5(1), AQP7(2), CD36(1), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), CYP4A11(1), CYP4A22(2), CYP7A1(1), CYP8B1(1), DBI(1), EHHADH(5), FABP2(1), FABP4(1), FABP6(2), FADS2(1), GK(1), HMGCS2(1), ILK(1), LPL(1), ME1(3), NR1H3(1), PCK2(2), PDPK1(1), PLTP(1), PPARA(2), PPARD(4), PPARG(1), RXRA(2), RXRB(2), RXRG(2), SCD(2), SCP2(3), SLC27A1(3), SLC27A5(2), SLC27A6(2), SORBS1(3), UBC(1), UCP1(1)	47193356	87	52	85	20	32	15	8	16	16	0	0.0209	1.000	1.000
416	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(5), ARPC5(1), ARPC5L(1), CD14(2), CDH1(4), CLDN1(1), CTTN(1), FYN(1), HCLS1(1), KRT18(1), LY96(1), NCL(1), PRKCA(2), RHOA(2), ROCK1(5), ROCK2(1), TLR4(2), TLR5(2), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2), WAS(2), YWHAQ(2), YWHAZ(1)	37496942	65	43	63	19	15	10	5	23	12	0	0.280	1.000	1.000
417	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(5), ARPC5(1), ARPC5L(1), CD14(2), CDH1(4), CLDN1(1), CTTN(1), FYN(1), HCLS1(1), KRT18(1), LY96(1), NCL(1), PRKCA(2), RHOA(2), ROCK1(5), ROCK2(1), TLR4(2), TLR5(2), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2), WAS(2), YWHAQ(2), YWHAZ(1)	37496942	65	43	63	19	15	10	5	23	12	0	0.280	1.000	1.000
418	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), GOT1(2), GOT2(1), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), MDH1(1), PC(2), PDHA1(1), PDHA2(4), PDHX(1), PFKL(2), PFKM(3), PFKP(3), PGAM2(1), PGK2(2), PKLR(1)	31271077	56	28	55	12	21	10	7	8	10	0	0.00893	1.000	1.000
419	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(7), ACACB(3), ACAT1(2), ACAT2(1), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ALDH7A1(2), ECHS1(1), EHHADH(5), HIBCH(1), LDHAL6A(1), LDHB(1), LDHC(1), MUT(3), SUCLA2(1)	29250501	40	29	40	14	10	5	6	14	4	1	0.549	1.000	1.000
420	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(1), ATP5A1(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G3(1), ATP5J(1), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(2), COX4I2(1), COX7A1(2), COX7C(1), CYC1(1), LHPP(1), NDUFA10(2), NDUFA12(1), NDUFA13(2), NDUFA5(1), NDUFA7(1), NDUFA9(1), NDUFB10(2), NDUFB7(1), NDUFB9(1), NDUFS2(2), NDUFS3(2), NDUFV1(1), SDHA(3), SDHB(2), SDHC(2), TCIRG1(1), UQCRC1(2)	41015058	68	43	68	17	16	14	11	16	11	0	0.0738	1.000	1.000
421	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(3), AKT2(1), AKT3(1), CDKN2A(1), CREB1(1), EBP(1), ERBB4(4), GAB1(1), GRB2(1), GSK3A(3), GSK3B(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS2(2), IRS4(3), MET(4), MYC(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PARD3(3), PDK1(2), PIK3CD(5), PPP1R13B(3), PREX1(1), PTK2(3), PTPN1(2), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1), TSC1(2), TSC2(7), YWHAB(1), YWHAQ(2), YWHAZ(1)	54439393	87	55	86	27	30	12	4	21	20	0	0.233	1.000	1.000
422	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT1(2), B4GALT2(2), G6PC(1), G6PC2(1), GAA(1), GALK1(1), GALK2(1), GALT(1), GANC(3), GCK(4), GLB1(2), HK1(2), HK2(4), HK3(4), LCT(6), MGAM(4), PFKL(2), PFKM(3), PFKP(3), PGM3(1), RDH12(1), UGP2(1)	28305603	50	31	50	19	25	4	4	11	6	0	0.359	1.000	1.000
423	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(3), PGM3(1), PKLR(1)	35983892	67	37	65	16	23	10	9	14	11	0	0.0267	1.000	1.000
424	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(3), PGM3(1), PKLR(1)	35983892	67	37	65	16	23	10	9	14	11	0	0.0267	1.000	1.000
425	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AKR1A1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), DAK(1), DGAT1(1), DGAT2(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), GK(1), GLB1(2), GPAM(2), LCT(6), LIPC(1), LIPG(5), LPL(1), MGLL(1), PNLIP(4), PNLIPRP1(1), PPAP2A(1), PPAP2B(1)	43027161	76	51	76	27	22	10	7	21	16	0	0.423	1.000	1.000
426	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(7), ACACB(3), ACAT1(2), ACAT2(1), ACOT12(2), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), DLAT(1), DLD(2), HAGH(1), LDHAL6A(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(1), ME3(1), PC(2), PCK2(2), PDHA1(1), PDHA2(4), PKLR(1)	34419352	49	34	48	13	10	9	8	14	7	1	0.144	1.000	1.000
427	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AKT1(3), CALM1(1), CALR(1), CAMK1(3), CAMK1G(2), CAMK4(4), CREBBP(8), F2(2), GATA4(1), GSK3B(1), HRAS(4), MAPK1(1), MEF2C(3), MYH2(7), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NPPA(1), PIK3R1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RAF1(1), SYT1(1)	35864070	65	40	62	25	21	9	8	18	9	0	0.572	1.000	1.000
428	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(1), IPMK(1), ITPK1(1), ITPKB(2), OCRL(3), PI4KA(4), PI4KB(2), PIK3C3(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), SYNJ1(3), SYNJ2(3)	52493527	79	59	79	26	25	14	9	21	10	0	0.213	1.000	1.000
429	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(3), AKT2(1), AKT3(1), BRD4(3), CBL(1), CDKN2A(1), GRB2(1), GSK3A(3), GSK3B(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS2(2), IRS4(3), LNPEP(1), MAPK1(1), PARD3(3), PDK1(2), PIK3CD(5), PIK3R1(2), PTPN1(2), RAF1(1), RPS6KA1(2), RPS6KA2(2), SHC1(3), SORBS1(3), SOS1(4), SOS2(1), YWHAB(1), YWHAQ(2), YWHAZ(1)	41661873	61	44	60	20	19	8	3	14	17	0	0.455	1.000	1.000
430	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), AOX1(2), CARM1(2), DBH(5), ECH1(1), ESCO1(5), ESCO2(1), FAH(1), GOT1(2), GOT2(1), HEMK1(1), HGD(1), HPD(2), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), NAT6(1), PNMT(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), SH3GLB1(1), TPO(5), TYR(2), TYRP1(1)	43728130	63	48	63	23	18	9	7	16	13	0	0.548	1.000	1.000
431	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), AKT1(3), AKT2(1), AKT3(1), ARHGAP5(4), BCAR1(3), BIRC2(1), CAPN2(2), CAV1(1), CAV3(1), CCND3(1), CHAD(1), COL11A2(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), COMP(2), CRK(1), DIAPH1(2), DOCK1(4), EGF(3), EGFR(3), ERBB2(6), FARP2(3), FIGF(1), FLNA(1), FLNB(6), FLNC(8), FLT1(5), FN1(5), FYN(1), GRB2(1), GSK3B(1), HGF(3), HRAS(4), IGF1R(4), ILK(1), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(3), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), KDR(7), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), MAPK1(1), MET(4), MYL5(1), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PARVB(1), PARVG(3), PDGFA(2), PDGFB(1), PDGFC(1), PDGFD(3), PDGFRA(3), PDGFRB(1), PDPK1(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PRKCA(2), PRKCG(1), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RAP1A(1), RAPGEF1(4), RELN(10), RHOA(2), ROCK1(5), ROCK2(1), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TLN1(4), TLN2(5), TNC(4), TNN(5), TNR(2), TNXB(12), VAV1(3), VAV2(3), VAV3(4), VCL(1), VEGFA(2), VTN(1), VWF(6)	265026246	456	223	449	166	153	88	35	109	69	2	0.126	1.000	1.000
432	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADORA1(3), ADORA2A(2), ADORA3(3), ADRA1A(1), ADRA1B(2), ADRA2A(2), ADRA2B(2), ADRA2C(2), ADRB1(1), AGTR1(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CALCR(4), CALCRL(1), CCKAR(2), CCKBR(2), CGA(1), CHRM2(2), CHRM3(1), CHRM4(3), CNR1(5), CNR2(1), CRHR2(2), CTSG(2), CYSLTR1(2), CYSLTR2(1), DRD2(1), DRD3(2), DRD4(1), DRD5(1), EDNRA(1), F2(2), F2R(2), F2RL1(1), FPR1(3), FSHR(2), GABBR1(1), GABBR2(3), GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), GABRB1(6), GABRB2(3), GABRB3(1), GABRD(2), GABRE(4), GABRG1(5), GABRG2(1), GABRP(2), GABRQ(1), GABRR1(2), GABRR2(3), GH1(3), GH2(1), GHR(1), GHRHR(1), GHSR(1), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(2), GLRA2(3), GNRHR(4), GPR156(2), GPR35(1), GPR50(4), GPR63(2), GPR83(2), GRIA1(12), GRIA2(5), GRIA3(1), GRIA4(4), GRID1(4), GRID2(6), GRIK1(5), GRIK2(1), GRIK3(6), GRIK4(3), GRIK5(1), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), GRIN3A(3), GRIN3B(1), GRM1(9), GRM2(2), GRM3(4), GRM4(2), GRM5(5), GRM6(3), GRM7(2), GRM8(2), GRPR(1), GZMA(1), HCRTR2(5), HRH1(1), HRH2(1), HRH4(2), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), LEPR(2), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(2), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), P2RX1(2), P2RX4(1), P2RX5(2), P2RY1(1), P2RY10(1), P2RY11(2), P2RY14(2), P2RY2(2), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PRL(1), PRLR(1), PRSS1(2), PTGER2(2), PTGER4(1), PTGIR(3), PTH2R(1), RXFP1(2), RXFP2(1), SCTR(3), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), SSTR5(2), TAAR2(1), TAAR5(1), TAAR6(3), TAAR8(3), TACR1(2), TACR2(1), TACR3(2), TBXA2R(5), THRA(6), TRHR(1), TRPV1(1), TSHR(1)	163340010	405	218	398	129	189	56	27	93	40	0	0.000726	1.000	1.000
433	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY8(7), ADCY9(5), ADORA2A(2), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), AGTR1(3), ATP2A1(5), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(7), ATP2B3(7), ATP2B4(5), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1F(2), CACNA1G(4), CACNA1H(3), CACNA1I(2), CACNA1S(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CAMK4(4), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CHRM3(1), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EGFR(3), ERBB2(6), ERBB3(5), ERBB4(4), F2R(2), GNA11(1), GNA14(1), GNAL(3), GNAS(2), GRIN1(3), GRIN2A(11), GRIN2C(3), GRM1(9), GRM5(5), GRPR(1), HRH1(1), HRH2(1), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), LHCGR(1), MYLK(4), MYLK2(4), NOS1(3), NOS3(2), NTSR1(3), P2RX1(2), P2RX4(1), P2RX5(2), PDE1B(1), PDE1C(3), PDGFRA(3), PDGFRB(1), PHKA1(2), PHKA2(2), PHKB(3), PHKG2(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), PLN(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RYR1(20), RYR2(17), RYR3(18), SLC25A6(1), SLC8A1(7), SLC8A2(1), SLC8A3(4), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(5), TRHR(1), VDAC1(1)	196886616	402	212	400	160	167	57	24	95	59	0	0.365	1.000	1.000
434	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	ABI2(1), ACTN1(1), ACTN2(2), ACTN4(3), APC(10), APC2(3), ARAF(1), ARHGEF1(5), ARHGEF12(1), ARHGEF4(1), ARHGEF6(1), ARHGEF7(1), ARPC5(1), ARPC5L(1), BAIAP2(1), BCAR1(3), BDKRB1(3), BDKRB2(2), CD14(2), CFL1(1), CHRM2(2), CHRM3(1), CHRM4(3), CRK(1), CYFIP1(4), CYFIP2(6), DIAPH1(2), DIAPH3(2), DOCK1(4), EGF(3), EGFR(3), F2(2), F2R(2), FGD1(2), FGD3(2), FGF10(2), FGF11(1), FGF16(2), FGF20(1), FGF21(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(3), FGFR3(2), FN1(5), GIT1(1), GNA13(2), GSN(6), HRAS(4), IQGAP1(3), IQGAP2(2), IQGAP3(2), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(5), ITGAE(1), ITGAL(5), ITGAM(3), ITGAV(3), ITGAX(3), ITGB2(2), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), KRAS(2), LIMK1(2), LIMK2(4), MAPK1(1), MOS(1), MRAS(2), MSN(1), MYH10(7), MYH14(3), MYH9(6), MYL5(1), MYLK(4), MYLK2(4), NCKAP1(1), NCKAP1L(6), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDGFA(2), PDGFB(1), PDGFRA(3), PDGFRB(1), PFN1(1), PFN2(3), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PPP1R12B(1), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RDX(1), RHOA(2), ROCK1(5), ROCK2(1), RRAS2(2), SCIN(1), SLC9A1(2), SOS1(4), SOS2(1), SSH1(3), SSH2(8), SSH3(3), TIAM1(5), TIAM2(6), VAV1(3), VAV2(3), VAV3(4), VCL(1), WAS(2), WASF1(2), WASF2(2)	199827943	374	204	367	118	120	57	36	99	61	1	0.0388	1.000	1.000
435	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	245	ACVR1B(2), ACVR1C(1), AKT1(3), AKT2(1), AKT3(1), ARRB1(1), ATF2(3), ATF4(1), BDNF(2), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1F(2), CACNA1G(4), CACNA1H(3), CACNA1I(2), CACNA1S(4), CACNA2D1(2), CACNA2D2(3), CACNA2D3(1), CACNA2D4(2), CACNB1(3), CACNB2(3), CACNB4(1), CACNG1(1), CACNG3(1), CACNG4(1), CACNG5(1), CACNG7(4), CACNG8(1), CD14(2), CDC25B(5), CRK(1), DAXX(2), DUSP1(1), DUSP14(1), DUSP16(1), DUSP7(1), DUSP8(3), ECSIT(2), EGF(3), EGFR(3), FAS(1), FASLG(1), FGF10(2), FGF11(1), FGF16(2), FGF20(1), FGF21(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(3), FGFR3(2), FLNA(1), FLNB(6), FLNC(8), GRB2(1), HRAS(4), IKBKB(1), IL1A(1), IL1R2(1), JUND(2), KRAS(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K8(1), MAP4K1(2), MAP4K2(1), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK13(1), MAPK8IP3(4), MAPKAPK3(1), MAPKAPK5(1), MEF2C(3), MOS(1), MRAS(2), MYC(1), NF1(4), NFATC2(2), NFATC4(1), NFKB1(3), NLK(1), NR4A1(1), NTF3(2), NTRK1(9), PAK1(1), PAK2(2), PDGFA(2), PDGFB(1), PDGFRA(3), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(3), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP5C(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), PTPN5(3), PTPN7(4), PTPRR(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RAP1A(1), RAPGEF2(2), RASA1(1), RASGRF1(3), RASGRF2(3), RASGRP2(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), RPS6KA5(3), RPS6KA6(1), RRAS2(2), SOS1(4), SOS2(1), STK3(1), STK4(3), TAOK1(3), TAOK2(3), TAOK3(2), TGFB2(2), TGFBR1(2), TNF(1), TNFRSF1A(1), TRAF2(5), TRAF6(2)	207304878	355	182	352	144	127	57	33	75	62	1	0.655	1.000	1.000
436	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(1), ACTG1(2), CHAD(1), COL11A2(4), COL17A1(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), COMP(2), DSC1(2), DSC3(2), DSG1(1), DSG2(4), DSG4(2), FN1(5), GJA1(1), GJA3(1), GJA4(2), GJA5(3), GJA8(5), GJB2(1), GJB4(2), GJB5(2), GJB6(1), GJC2(2), ITGA6(2), ITGB4(4), KRT1(1), KRT10(1), KRT12(1), KRT13(2), KRT14(1), KRT15(2), KRT16(4), KRT18(1), KRT19(1), KRT2(1), KRT23(2), KRT24(2), KRT25(6), KRT27(4), KRT28(1), KRT3(2), KRT31(4), KRT33A(1), KRT33B(1), KRT36(2), KRT37(2), KRT38(2), KRT39(2), KRT4(3), KRT40(2), KRT5(1), KRT6A(1), KRT6B(2), KRT6C(4), KRT7(3), KRT72(1), KRT73(2), KRT75(2), KRT76(2), KRT77(1), KRT78(5), KRT79(2), KRT81(1), KRT83(1), KRT84(1), KRT85(3), KRT86(1), KRT9(2), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), LMNA(4), LMNB2(2), NES(3), RELN(10), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNC(4), TNN(5), TNR(2), TNXB(12), VIM(1), VTN(1), VWF(6)	179659989	323	162	322	100	141	62	12	61	46	1	0.00296	1.000	1.000
437	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), ANXA6(2), ARRB1(1), ATP1A4(1), ATP1B2(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(7), ATP2B3(7), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1S(4), CACNB1(3), CALM1(1), CALR(1), CAMK1(3), CAMK2A(1), CAMK2D(2), CAMK4(4), CHRM2(2), CHRM3(1), CHRM4(3), GJA1(1), GJA4(2), GJA5(3), GJB2(1), GJB4(2), GJB5(2), GJB6(1), GNA11(1), GNAI2(2), GNAO1(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(1), GRK6(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNB1(4), KCNJ5(2), MIB1(2), NME7(1), PLN(1), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RGS11(1), RGS16(2), RGS18(1), RGS3(2), RGS6(3), RGS7(1), RGS9(2), RYR1(20), RYR2(17), RYR3(18), SLC8A1(7), SLC8A3(4), USP5(1), YWHAB(1), YWHAQ(2)	137346408	286	157	285	117	133	34	17	63	39	0	0.489	1.000	1.000
438	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(3), CD36(1), CD47(1), CHAD(1), COL11A2(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), DAG1(2), FN1(5), FNDC1(6), FNDC3A(2), GP5(4), GP9(1), HMMR(1), HSPG2(12), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(3), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), RELN(10), SDC3(1), SDC4(1), SV2A(3), SV2B(2), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNC(4), TNN(5), TNR(2), TNXB(12), VTN(1), VWF(6)	161179154	276	148	274	87	103	53	14	60	45	1	0.0185	1.000	1.000
439	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), AKT1(3), AKT2(1), AKT3(1), ASH1L(7), CGN(4), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTTN(1), EPB41L1(2), EPB41L2(4), EXOC3(4), EXOC4(2), GNAI1(2), GNAI2(2), HCLS1(1), HRAS(4), IGSF5(1), INADL(5), JAM2(1), KRAS(2), LLGL1(3), LLGL2(2), MAGI1(2), MAGI2(2), MAGI3(3), MLLT4(5), MPDZ(3), MRAS(2), MYH1(4), MYH10(7), MYH11(7), MYH13(8), MYH14(3), MYH15(7), MYH2(7), MYH3(3), MYH4(9), MYH6(10), MYH7(7), MYH7B(4), MYH8(11), MYH9(6), MYL5(1), PARD3(3), PPM1J(1), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R4(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), RHOA(2), RRAS2(2), SPTAN1(2), SYMPK(2), TJAP1(2), TJP1(1), TJP2(5), TJP3(2), VAPA(2), YES1(1)	139524770	243	140	239	86	94	37	19	57	36	0	0.239	1.000	1.000
440	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(5), ABLIM1(3), ARHGEF12(1), CFL1(1), DCC(6), DPYSL5(1), EFNA2(1), EFNA3(1), EFNA5(2), EFNB2(1), EFNB3(2), EPHA1(5), EPHA2(2), EPHA3(5), EPHA4(4), EPHA5(1), EPHA6(2), EPHA7(2), EPHA8(2), EPHB1(8), EPHB2(4), EPHB3(4), EPHB6(3), FES(3), FYN(1), GNAI1(2), GNAI2(2), GSK3B(1), HRAS(4), KRAS(2), L1CAM(6), LIMK1(2), LIMK2(4), LRRC4C(3), MAPK1(1), MET(4), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NGEF(5), NRP1(2), NTN1(1), NTNG1(3), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PLXNA1(8), PLXNA2(3), PLXNA3(2), PLXNB1(4), PLXNB2(4), PLXNB3(1), PLXNC1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTK2(3), RAC1(1), RAC2(1), RAC3(2), RASA1(1), RGS3(2), RHOA(2), RHOD(2), ROBO1(7), ROBO2(10), ROBO3(2), ROCK1(5), ROCK2(1), SEMA3A(2), SEMA3C(3), SEMA3D(4), SEMA3E(2), SEMA3F(4), SEMA3G(2), SEMA4A(1), SEMA4C(3), SEMA4F(2), SEMA4G(2), SEMA5A(5), SEMA5B(2), SEMA6A(5), SEMA6C(3), SEMA6D(2), SEMA7A(2), SLIT1(2), SLIT2(3), SLIT3(4), SRGAP1(4), SRGAP3(2), UNC5A(1), UNC5B(5), UNC5D(3)	143530427	266	137	262	97	108	34	23	69	32	0	0.307	1.000	1.000
441	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1B(2), ACVR2A(2), BMP2(2), BMP7(3), BMPR1A(2), BMPR1B(2), BMPR2(3), CCL11(1), CCL15(1), CCL17(1), CCL21(1), CCL28(1), CCL7(1), CCL8(1), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CCR9(1), CD27(1), CD40(1), CD40LG(1), CNTF(1), CSF1(1), CSF1R(5), CSF2RA(3), CSF2RB(1), CSF3R(1), CX3CL1(1), CXCL9(1), CXCR6(1), EDA(1), EGF(3), EGFR(3), EPOR(1), FAS(1), FASLG(1), FLT1(5), FLT3(2), FLT3LG(1), FLT4(4), GH1(3), GH2(1), GHR(1), HGF(3), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(4), IL17RB(1), IL18RAP(2), IL1A(1), IL1R2(1), IL1RAP(2), IL20(1), IL20RA(2), IL21(2), IL21R(2), IL22(1), IL22RA2(1), IL23R(1), IL24(3), IL25(1), IL26(1), IL2RB(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL6ST(7), IL7(2), IL7R(1), IL9(2), INHBA(2), INHBC(2), INHBE(1), KDR(7), KIT(3), LEPR(2), LIFR(4), LTBR(2), MET(4), OSMR(1), PDGFB(1), PDGFC(1), PDGFRA(3), PDGFRB(1), PF4(1), PRL(1), PRLR(1), TGFB2(2), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11B(2), TNFRSF13B(3), TNFRSF18(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(7), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(3), TNFSF11(1), TNFSF12(1), TNFSF14(2), TNFSF15(1), TNFSF8(2), TPO(5), VEGFA(2), XCL1(1), XCR1(2)	130081861	236	132	236	84	61	38	26	67	43	1	0.264	1.000	1.000
442	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(10), APC2(3), AXIN1(1), AXIN2(5), BTRC(3), CACYBP(1), CAMK2A(1), CAMK2D(2), CCND3(1), CHD8(3), CREBBP(8), CSNK1A1L(1), CSNK1E(3), CSNK2A2(1), CSNK2B(1), CUL1(2), DAAM1(4), DAAM2(4), DKK1(3), DKK2(2), DVL1(1), DVL2(3), DVL3(1), EP300(7), FBXW11(2), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GSK3B(1), LEF1(2), LRP5(4), LRP6(4), MAP3K7(2), MYC(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NKD2(1), NLK(1), PLCB1(3), PLCB2(1), PLCB4(8), PPARD(4), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRICKLE1(2), PRICKLE2(7), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAC1(1), RAC2(1), RAC3(2), RHOA(2), ROCK1(5), ROCK2(1), RUVBL1(1), SFRP2(3), SFRP5(1), SMAD2(2), SMAD3(1), SMAD4(7), SOX17(1), TBL1X(1), TBL1XR1(2), TCF7(1), TCF7L1(1), TCF7L2(2), VANGL2(5), WIF1(2), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2)	117346679	223	127	220	82	69	41	24	46	43	0	0.325	1.000	1.000
443	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(3), ADORA2A(2), ADORA3(3), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(2), ADRB1(1), AGTR1(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CCR9(1), CCRL2(1), CHRM2(2), CHRM3(1), CHRM4(3), CMKLR1(2), CNR1(5), CNR2(1), DRD2(1), DRD3(2), DRD4(1), DRD5(1), EDNRA(1), F2R(2), F2RL1(1), FPR1(3), FSHR(2), GALT(1), GHSR(1), GPR17(2), GPR174(1), GPR35(1), GPR37(2), GPR37L1(3), GPR4(1), GPR50(4), GPR6(1), GPR63(2), GPR83(2), GPR87(3), GRPR(1), HCRTR2(5), HRH1(1), HRH2(1), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1A(1), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(2), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPN1SW(1), OPN3(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), OR12D3(1), OR1Q1(1), OR5V1(1), OR7A5(2), OR8B8(1), P2RY1(1), P2RY10(1), P2RY11(2), P2RY14(2), P2RY2(2), P2RY6(1), PTGER2(2), PTGER4(1), PTGIR(3), RGR(2), RHO(1), RRH(1), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), TBXA2R(5), TRHR(1)	89410440	214	126	212	77	91	36	13	55	19	0	0.0422	1.000	1.000
444	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(7), ACACB(3), AKT1(3), AKT2(1), AKT3(1), ARAF(1), CALM1(1), CALML3(1), CALML6(1), CBL(1), CBLB(1), CBLC(1), CRK(1), EXOC7(1), FASN(5), FBP1(2), FBP2(1), FOXO1(1), G6PC(1), G6PC2(1), GCK(4), GRB2(1), GSK3B(1), GYS1(4), HRAS(4), IKBKB(1), INPP5D(3), IRS1(3), IRS2(2), IRS4(3), KRAS(2), MAPK1(1), PCK2(2), PDE3A(2), PDE3B(3), PDPK1(1), PFKL(2), PFKM(3), PFKP(3), PHKA1(2), PHKA2(2), PHKB(3), PHKG2(2), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PKLR(1), PPARGC1A(4), PPP1CA(1), PPP1R3A(7), PPP1R3B(2), PRKAA2(5), PRKACA(2), PRKAG1(3), PRKAG3(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCI(1), PRKCZ(3), PRKX(2), PTPN1(2), PTPRF(5), PYGB(4), PYGL(4), PYGM(1), RAF1(1), RAPGEF1(4), RPS6(1), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOCS4(2), SORBS1(3), SOS1(4), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(7)	114672197	204	124	199	66	76	31	28	43	25	1	0.0549	1.000	1.000
445	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(2), CADM1(2), CADM3(3), CD2(1), CD226(2), CD276(1), CD28(2), CD34(1), CD4(1), CD40(1), CD40LG(1), CD6(1), CD86(1), CD8A(1), CD8B(2), CDH1(4), CDH15(1), CDH2(2), CDH3(3), CDH4(5), CDH5(5), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CNTN2(1), CNTNAP1(9), CNTNAP2(2), ESAM(1), GLG1(2), HLA-A(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), ICAM1(1), ICAM2(2), ICAM3(1), ITGA4(3), ITGA6(2), ITGA8(3), ITGA9(4), ITGAL(5), ITGAM(3), ITGAV(3), ITGB2(2), ITGB7(1), ITGB8(2), JAM2(1), L1CAM(6), MADCAM1(1), MAG(2), NCAM1(1), NCAM2(3), NEGR1(3), NEO1(4), NFASC(3), NLGN1(1), NLGN2(1), NLGN3(2), NRCAM(4), NRXN1(3), NRXN2(2), NRXN3(8), PDCD1(1), PTPRC(8), PTPRF(5), PTPRM(1), PVRL1(2), PVRL2(2), PVRL3(1), SDC3(1), SDC4(1), SELE(1), SELP(4), SELPLG(2), SIGLEC1(8), SPN(1), VCAM1(2), VCAN(4)	108188392	197	122	193	70	72	35	17	42	31	0	0.181	1.000	1.000
446	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(1), CACNA1A(12), GNA11(1), GNA13(2), GNAI1(2), GNAI2(2), GNAO1(1), GNAS(2), GNAZ(3), GRIA1(12), GRIA2(5), GRIA3(1), GRID2(6), GRM1(9), GRM5(5), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), HRAS(4), IGF1R(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), LYN(2), MAPK1(1), NOS1(3), NOS3(2), NPR1(1), NPR2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(1), PLCB4(8), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PRKCA(2), PRKCG(1), PRKG1(1), RAF1(1), RYR1(20)	79709946	174	122	169	50	71	23	12	47	21	0	0.0486	1.000	1.000
447	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ARRB1(1), ATF2(3), ATF3(1), ATF4(1), ATF5(1), ATP2A2(1), ATP2A3(1), CALCA(1), CALM1(1), CAMK2A(1), CAMK2D(2), CNN1(1), CORIN(4), DGKZ(3), GBA2(1), GJA1(1), GNB1(1), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(1), GRK6(2), GSTO1(2), GUCY1A3(1), IGFBP1(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL6(1), ITPR1(4), ITPR2(8), ITPR3(6), MAFF(1), MIB1(2), MYLK2(4), NFKB1(3), NOS1(3), NOS3(2), PLCD1(1), PLCG1(1), PLCG2(3), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RAMP1(1), RAMP2(1), RAMP3(1), RGS11(1), RGS16(2), RGS18(1), RGS3(2), RGS6(3), RGS7(1), RGS9(2), RYR1(20), RYR2(17), RYR3(18), SLC8A1(7), SP1(2), TNXB(12), USP5(1), YWHAB(1), YWHAQ(2)	126857847	226	121	226	105	90	36	14	50	36	0	0.872	1.000	1.000
448	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(3), AKT2(1), AKT3(1), CBL(1), CBLB(1), CBLC(1), CCND3(1), CNTF(1), CREBBP(8), CSF2RA(3), CSF2RB(1), CSF3R(1), EP300(7), EPOR(1), GH1(3), GH2(1), GHR(1), GRB2(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL20(1), IL20RA(2), IL21(2), IL21R(2), IL22(1), IL22RA2(1), IL23R(1), IL24(3), IL26(1), IL2RB(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL6ST(7), IL7(2), IL7R(1), IL9(2), JAK1(6), JAK2(1), JAK3(1), LEPR(2), LIFR(4), MYC(1), OSMR(1), PIAS3(2), PIAS4(3), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRL(1), PRLR(1), PTPN11(1), SOCS4(2), SOCS5(2), SOS1(4), SOS2(1), SPRED2(2), SPRY3(1), STAM2(1), STAT1(1), STAT2(2), STAT3(6), STAT4(6), STAT5B(2), STAT6(3), TPO(5), TYK2(2)	105430214	177	111	176	62	41	29	24	44	39	0	0.351	1.000	1.000
449	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADSL(1), ADSS(1), AK2(1), AK5(1), AK7(2), ALLC(1), AMPD1(4), AMPD2(4), AMPD3(1), APRT(1), ATIC(5), DGUOK(1), ENPP1(3), ENPP3(2), ENTPD1(1), ENTPD3(2), ENTPD4(2), ENTPD6(2), FHIT(1), GART(1), GMPR(3), GMPR2(1), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), NME1(1), NME7(1), NPR1(1), NPR2(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), PAPSS2(1), PDE10A(5), PDE1C(3), PDE2A(2), PDE3B(3), PDE4A(3), PDE4C(1), PDE5A(1), PDE6D(1), PDE7A(1), PDE8A(5), PDE8B(1), PDE9A(4), PFAS(2), PKLR(1), POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3), PPAT(1), PRIM2(2), PRPS1L1(4), RFC5(1), RRM2(1), XDH(1)	119593105	180	105	180	70	64	41	15	38	22	0	0.438	1.000	1.000
450	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADRB1(1), DRD2(1), EGF(3), EGFR(3), GJA1(1), GNA11(1), GNAI1(2), GNAI2(2), GNAS(2), GRB2(1), GRM1(9), GRM5(5), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), HRAS(4), HTR2A(2), HTR2B(2), HTR2C(3), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAPK1(1), NPR1(1), NPR2(1), PDGFA(2), PDGFB(1), PDGFC(1), PDGFD(3), PDGFRA(3), PDGFRB(1), PLCB1(3), PLCB2(1), PLCB4(8), PRKACA(2), PRKCA(2), PRKCG(1), PRKG1(1), PRKX(2), RAF1(1), SOS1(4), SOS2(1), TJP1(1), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2)	97374256	163	105	160	62	59	26	10	49	19	0	0.431	1.000	1.000
451	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(1), ACTN2(2), ACTN4(3), ARHGAP5(4), BCAR1(3), CDH5(5), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTNND1(1), CYBB(2), ESAM(1), GNAI1(2), GNAI2(2), ICAM1(1), ITGA4(3), ITGAL(5), ITGAM(3), ITGB2(2), ITK(3), JAM2(1), MAPK12(1), MAPK13(1), MLLT4(5), MMP9(5), MSN(1), MYL5(1), NCF1(1), NCF2(3), NCF4(3), NOX3(5), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCG(1), PTK2(3), PTPN11(1), PXN(1), RAC1(1), RAC2(1), RAP1A(1), RAPGEF3(1), RAPGEF4(3), RASSF5(1), RHOA(2), ROCK1(5), ROCK2(1), SIPA1(5), VAV1(3), VAV2(3), VAV3(4), VCAM1(2), VCL(1)	88340110	158	104	155	58	59	18	18	35	28	0	0.478	1.000	1.000
452	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(2), ADCY8(7), ARAF(1), ATF4(1), CACNA1C(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CAMK4(4), CREBBP(8), EP300(7), GRIA1(12), GRIA2(5), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), GRM1(9), GRM5(5), HRAS(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAPK1(1), PLCB1(3), PLCB2(1), PLCB4(8), PPP1CA(1), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), RAP1A(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1)	71780130	155	104	150	52	51	22	10	51	21	0	0.308	1.000	1.000
453	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(1), BCAR1(3), CAPN1(2), CAPN10(1), CAPN11(5), CAPN2(2), CAPN3(1), CAPN5(1), CAPN6(1), CAPN7(1), CAPNS1(2), CAV1(1), CAV3(1), CRK(1), DOCK1(4), FYN(1), GIT2(2), GRB2(1), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(5), ITGAE(1), ITGAL(5), ITGAM(3), ITGAV(3), ITGAX(3), ITGB2(2), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), MAP2K3(1), MAP2K6(1), MAPK12(1), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PDPK1(1), PIK3R2(3), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAPGEF1(4), RHO(1), ROCK1(5), ROCK2(1), SHC1(3), SHC3(1), SORBS1(3), SOS1(4), TLN1(4), TNS1(6), VAV2(3), VAV3(4), VCL(1)	98316300	173	104	170	52	47	31	13	52	30	0	0.0736	1.000	1.000
454	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(2), ACTN4(3), DMD(5), MYBPC1(2), MYBPC2(5), MYBPC3(3), MYH3(3), MYH6(10), MYH7(7), MYH8(11), MYL1(1), MYOM1(5), NEB(9), TCAP(2), TNNI1(1), TNNT3(1), TPM1(1), TPM2(1), TPM4(1), TTN(87), VIM(1)	99952471	162	103	161	44	52	27	24	39	18	2	0.0391	1.000	1.000
455	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDH1(4), CREBBP(8), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTNND1(1), EGFR(3), EP300(7), ERBB2(6), FARP2(3), FER(1), FGFR1(2), FYN(1), IGF1R(4), IQGAP1(3), LEF1(2), LMO7(1), MAP3K7(2), MAPK1(1), MET(4), MLLT4(5), NLK(1), PARD3(3), PTPN1(2), PTPRB(5), PTPRF(5), PTPRJ(1), PTPRM(1), PVRL1(2), PVRL2(2), PVRL3(1), PVRL4(1), RAC1(1), RAC2(1), RAC3(2), RHOA(2), SMAD2(2), SMAD3(1), SMAD4(7), SNAI1(1), SORBS1(3), SSX2IP(1), TCF7(1), TCF7L1(1), TCF7L2(2), TGFBR1(2), TJP1(1), VCL(1), WAS(2), WASF1(2), WASF2(2), WASF3(1), YES1(1)	87008286	144	94	142	44	45	22	17	40	20	0	0.146	1.000	1.000
456	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CREB1(1), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(8), DVL1(1), DVL2(3), DVL3(1), EP300(7), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GNAI1(2), GNAI2(2), GNAO1(1), GNAS(2), GSK3B(1), HRAS(4), KIT(3), KRAS(2), LEF1(2), MAPK1(1), MITF(1), PLCB1(3), PLCB2(1), PLCB4(8), POMC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), TCF7(1), TCF7L1(1), TCF7L2(2), TYR(2), TYRP1(1), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2)	78942312	147	92	145	74	55	28	13	33	18	0	0.851	1.000	1.000
457	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(1), CALML3(1), CALML6(1), CDS1(3), CDS2(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPP5B(2), INPP5D(3), INPP5E(2), INPPL1(1), ITPK1(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), OCRL(3), PI4KA(4), PI4KB(2), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3C3(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), PRKCA(2), PRKCG(1), SYNJ1(3), SYNJ2(3)	89295161	147	91	147	51	46	28	14	35	24	0	0.290	1.000	1.000
458	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ATF4(1), CACNA1C(4), CACNA1D(4), CACNA1F(2), CACNA1S(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CGA(1), EGFR(3), GNA11(1), GNAS(2), GNRHR(4), GRB2(1), HRAS(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K3(1), MAP3K4(3), MAPK1(1), MAPK12(1), MAPK13(1), MMP14(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(1), PLCB4(8), PLD1(3), PLD2(2), PRKACA(2), PRKCA(2), PRKX(2), RAF1(1), SOS1(4), SOS2(1)	92824624	145	91	143	56	45	28	8	39	25	0	0.541	1.000	1.000
459	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(2), ACVR1C(1), ACVR2A(2), ACVRL1(3), BMP2(2), BMP4(1), BMP5(4), BMP6(1), BMP7(3), BMP8B(1), BMPR1A(2), BMPR1B(2), BMPR2(3), CHRD(1), COMP(2), CREBBP(8), CUL1(2), DCN(2), EP300(7), FST(1), GDF6(1), GDF7(2), INHBA(2), INHBC(2), INHBE(1), LEFTY1(1), LTBP1(5), MAPK1(1), MYC(1), NODAL(1), PITX2(3), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), RBL1(2), RBL2(2), RHOA(2), ROCK1(5), ROCK2(1), RPS6KB2(2), SMAD2(2), SMAD3(1), SMAD4(7), SMAD6(2), SMAD7(1), SMAD9(1), SMURF1(1), SMURF2(1), SP1(2), TFDP1(2), TGFB2(2), TGFBR1(2), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNF(1), ZFYVE16(3), ZFYVE9(1)	72899279	135	90	132	39	35	25	22	34	19	0	0.0837	1.000	1.000
460	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	ARAF(1), CD247(1), CD48(4), FAS(1), FASLG(1), FYN(1), GRB2(1), HLA-A(1), HLA-G(2), HRAS(4), ICAM1(1), ICAM2(2), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), ITGAL(5), ITGB2(2), KIR3DL1(2), KLRC1(1), KRAS(2), LCP2(2), MAPK1(1), MICB(1), NCR1(1), NCR2(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PAK1(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRF1(2), PRKCA(2), PRKCG(1), PTPN11(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), VAV1(3), VAV2(3), VAV3(4), ZAP70(6)	80620264	138	88	135	55	51	16	18	28	25	0	0.610	1.000	1.000
461	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(6), AMY2A(1), AMY2B(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(6), DDX41(4), DDX47(3), DDX50(4), DDX56(2), ENPP1(3), ENPP3(2), ENTPD7(1), EP400(4), ERCC2(3), ERCC3(1), G6PC(1), G6PC2(1), GAA(1), GANC(3), GBE1(2), GCK(4), GYS1(4), HK1(2), HK2(4), HK3(4), MGAM(4), MOV10L1(2), PGM3(1), PYGB(4), PYGL(4), PYGM(1), RAD54B(4), RAD54L(2), RUVBL2(3), SETX(6), SI(6), SKIV2L2(4), SMARCA2(3), SMARCA5(3), UGDH(2), UGP2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3)	91255905	149	86	148	50	37	25	25	40	22	0	0.354	1.000	1.000
462	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(5), AKT1(3), AKT2(1), AKT3(1), ARAF(1), CAMK2A(1), CAMK2D(2), CBL(1), CBLB(1), CBLC(1), CDKN1A(2), CRK(1), EGF(3), EGFR(3), ERBB2(6), ERBB3(5), ERBB4(4), GAB1(1), GRB2(1), GSK3B(1), HRAS(4), KRAS(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MYC(1), NRG1(4), NRG2(4), NRG3(3), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCG(1), PTK2(3), RAF1(1), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), STAT5B(2)	72466475	131	86	128	48	45	20	14	29	23	0	0.399	1.000	1.000
463	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(5), ANAPC1(4), ANAPC2(4), ANAPC4(1), ANAPC5(3), ANAPC7(1), ATR(3), BUB1(2), BUB1B(3), BUB3(1), CCNA1(1), CCNB2(1), CCND3(1), CCNE2(1), CCNH(1), CDC14B(2), CDC16(1), CDC20(2), CDC23(3), CDC25A(4), CDC25B(5), CDC27(2), CDC6(1), CDC7(2), CDK7(2), CDKN1A(2), CDKN2A(1), CREBBP(8), CUL1(2), DBF4(1), E2F1(3), E2F3(1), EP300(7), ESPL1(3), FZR1(4), GSK3B(1), HDAC1(1), HDAC2(1), MAD1L1(4), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), PCNA(2), PLK1(1), PRKDC(11), PTTG1(1), RB1(3), RBL1(2), RBL2(2), SMAD2(2), SMAD3(1), SMAD4(7), SMC1A(1), SMC1B(1), TFDP1(2), TGFB2(2), WEE1(1), YWHAB(1), YWHAQ(2), YWHAZ(1)	94381475	155	86	155	39	46	23	26	32	27	1	0.0253	1.000	1.000
464	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADSL(1), ADSS(1), AK2(1), AK5(1), ALLC(1), AMPD1(4), AMPD2(4), AMPD3(1), APRT(1), ATIC(5), ATP5A1(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G3(1), ATP5J(1), DGUOK(1), ENPP1(3), ENPP3(2), ENTPD1(1), FHIT(1), GART(1), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), NME1(1), NPR1(1), NPR2(1), NT5E(1), NT5M(1), PAPSS2(1), PDE4A(3), PDE4C(1), PDE5A(1), PDE6B(2), PDE6C(1), PDE8A(5), PDE9A(4), PFAS(2), PKLR(1), POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1), PPAT(1), PRPS1L1(4), RRM2(1)	93838956	141	84	141	60	47	29	17	30	18	0	0.790	1.000	1.000
465	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(5), ACTN1(1), ACTR3(1), AKT1(3), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF6(1), ARHGEF7(1), BCAR1(3), CAV1(1), CDKN2A(1), CRK(1), CSE1L(1), DOCK1(4), EPHB2(4), FYN(1), GRB2(1), GRB7(2), ILK(1), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), MAP2K4(4), MAP2K7(4), MAP3K11(1), MAPK1(1), MAPK8IP3(4), MRAS(2), MYLK(4), MYLK2(4), P4HB(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PIK3CB(3), PKLR(1), PLCG1(1), PLCG2(3), PTK2(3), RAF1(1), RHO(1), ROCK1(5), ROCK2(1), SHC1(3), SOS1(4), SOS2(1), TERF2IP(1), TLN1(4), TLN2(5), WAS(2)	86597694	142	84	140	52	39	24	13	38	28	0	0.496	1.000	1.000
466	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), AKAP1(4), AKAP10(1), AKAP11(3), AKAP12(6), AKAP2(1), AKAP3(2), AKAP4(2), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(10), ARHGEF1(5), CALM1(1), GNA11(1), GNA13(2), GNA14(1), GNAI2(2), GNAL(3), GNAO1(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB5(1), GNGT1(1), HRAS(4), ITPR1(4), KRAS(2), PDE1B(1), PDE1C(3), PDE4A(3), PDE4C(1), PDE7A(1), PDE8A(5), PDE8B(1), PPP3CA(2), PPP3CC(2), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), PRKD1(2), PRKD3(1), RHOA(2), SLC9A1(2), USP5(1)	86151886	145	82	142	51	53	20	15	37	20	0	0.337	1.000	1.000
467	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(2), ACVRL1(3), AKT1(3), AURKB(2), BMPR1A(2), BMPR2(3), BUB1(2), CDKL1(1), CDKL2(5), CDS1(3), CDS2(1), CLK1(2), CLK2(1), COL4A3BP(3), CSNK2A2(1), CSNK2B(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPPL1(1), ITPKB(2), MAP3K10(4), MOS(1), NEK1(3), OCRL(3), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3CB(3), PIK3CG(7), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCG1(1), PLCG2(3), PLK3(3), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), STK11(1), TGFBR1(2)	81153616	145	82	144	44	43	26	21	36	19	0	0.103	1.000	1.000
468	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(5), BUB1(2), BUB1B(3), BUB3(1), CCNA1(1), CCNB2(1), CCND3(1), CCNE2(1), CCNH(1), CDAN1(1), CDC14B(2), CDC20(2), CDC25A(4), CDC25B(5), CDC6(1), CDC7(2), CDH1(4), CDKN1A(2), CDKN2A(1), DTX4(2), E2F1(3), E2F3(1), EP300(7), ESPL1(3), GSK3B(1), HDAC1(1), HDAC2(1), HDAC3(2), HDAC4(3), HDAC5(4), HDAC6(4), HDAC8(2), MAD1L1(4), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MPEG1(5), PCNA(2), PLK1(1), PRKDC(11), PTPRA(5), PTTG1(1), RB1(3), RBL1(2), SMAD4(7), TFDP1(2), WEE1(1)	75201356	135	79	135	31	41	24	18	30	21	1	0.0110	1.000	1.000
469	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(8), ABCA10(1), ABCA12(5), ABCA13(14), ABCA2(2), ABCA3(3), ABCA4(4), ABCA5(5), ABCA6(1), ABCA7(4), ABCA8(3), ABCA9(5), ABCB1(8), ABCB10(1), ABCB11(3), ABCB4(2), ABCB5(4), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(1), ABCC1(1), ABCC10(3), ABCC11(6), ABCC12(5), ABCC2(1), ABCC3(2), ABCC4(3), ABCC5(4), ABCC6(2), ABCC8(4), ABCC9(3), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(3), ABCG4(3), CFTR(3), TAP1(3), TAP2(1)	86750508	129	79	129	56	43	25	15	21	24	1	0.605	1.000	1.000
470	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(3), AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(1), GAB2(5), GRB2(1), HRAS(4), IL4(1), INPP5D(3), KRAS(2), LCP2(2), LYN(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAPK1(1), MAPK12(1), MAPK13(1), MS4A2(1), PDK1(2), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCE(2), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SOS1(4), SOS2(1), SYK(2), TNF(1), VAV1(3), VAV2(3), VAV3(4)	51501747	108	79	105	34	33	15	14	28	18	0	0.238	1.000	1.000
471	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(3), AKT2(1), AKT3(1), CARD11(5), CBL(1), CBLB(1), CBLC(1), CD247(1), CD28(2), CD3D(1), CD4(1), CD40LG(1), CD8A(1), CD8B(2), FYN(1), GRB2(1), HRAS(4), IKBKB(1), IL10(1), IL4(1), ITK(3), KRAS(2), LCP2(2), MAP3K8(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDCD1(1), PDK1(2), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCQ(3), PTPRC(8), RHOA(2), SOS1(4), SOS2(1), TEC(1), TNF(1), VAV1(3), VAV2(3), VAV3(4), ZAP70(6)	73188047	131	78	127	45	42	19	15	34	21	0	0.312	1.000	1.000
472	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG10B(3), ALG12(1), ALG13(1), ALG14(2), ALG8(1), ALG9(1), B3GNT1(1), B3GNT7(2), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT5(1), CHPF(1), CHST1(1), CHST11(3), CHST12(1), CHST13(1), CHST2(1), CHST3(3), CHST4(1), CHSY1(1), DDOST(1), EXT1(3), EXT2(3), EXTL1(3), EXTL3(4), FUT8(2), GALNT10(5), GALNT11(2), GALNT12(2), GALNT13(1), GALNT14(3), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GALNTL5(3), GANAB(3), GCNT1(2), GCNT3(1), GCNT4(1), HS2ST1(1), HS3ST3A1(1), HS6ST1(3), HS6ST2(1), MAN1A1(2), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT3(1), MGAT4A(1), MGAT5(1), MGAT5B(2), NDST1(3), NDST2(5), NDST3(3), NDST4(6), OGT(1), RPN1(1), RPN2(2), ST3GAL1(2), ST3GAL3(1), ST6GAL1(1), ST6GALNAC1(1), UST(1), WBSCR17(2), XYLT1(6), XYLT2(1)	80618444	136	77	136	45	47	23	15	29	22	0	0.237	1.000	1.000
473	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), BDKRB1(3), BDKRB2(2), C1QB(1), C1S(4), C2(1), C3(3), C3AR1(2), C4BPA(2), C5(3), C6(5), C8A(3), C8B(2), C9(3), CD46(2), CFB(3), CFD(1), CFH(9), CFI(1), CPB2(1), CR1(1), CR2(2), F10(3), F11(4), F12(1), F13A1(4), F13B(3), F2(2), F2R(2), F3(1), F5(5), F7(2), F8(1), FGA(5), FGB(2), FGG(1), KLKB1(2), MASP1(2), MASP2(2), PLAT(3), PLG(1), PROC(3), PROS1(3), SERPINA1(1), SERPINC1(2), SERPIND1(2), SERPINF2(1), SERPING1(2), VWF(6)	66545774	122	75	121	56	40	16	10	35	20	1	0.940	1.000	1.000
474	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(1), CALM1(1), CAMK4(4), CD69(2), CDKN1A(2), CEBPB(1), CNR1(5), CREBBP(8), CSNK2B(1), EGR3(1), EP300(7), FCER1A(1), GATA4(1), GSK3A(3), GSK3B(1), HRAS(4), IFNB1(1), IL10(1), IL4(1), IL6(1), ITK(3), KPNA5(3), MAP2K7(4), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKBIB(2), NFKBIE(1), NUP214(5), OPRD1(1), PAK1(1), PPIA(1), PPP3CB(1), PPP3CC(2), PTPRC(8), RELA(3), SP1(2), SP3(3), TNF(1), TRAF2(5), TRPV6(2), VAV1(3), VAV2(3), VAV3(4), XPO5(2)	67036779	118	74	116	41	37	18	13	33	17	0	0.336	1.000	1.000
475	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(3), CCKBR(2), CCR2(3), CCR3(1), CCR5(2), CELSR1(4), CELSR2(11), CELSR3(9), CHRM2(2), CHRM3(1), DRD4(1), EDNRA(1), EMR2(7), F2R(2), FSHR(2), GHRHR(1), GNRHR(4), GPR116(2), GPR132(1), GPR133(2), GPR17(2), GPR18(2), GPR55(2), GPR56(1), GPR84(1), GRM1(9), GRPR(1), HRH4(2), LGR6(3), LPHN2(6), LPHN3(9), NTSR1(3), OR2M4(2), P2RY11(2), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2)	48912646	111	71	109	38	46	17	10	28	10	0	0.0894	1.000	1.000
476	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(3), AKT2(1), AKT3(1), BTK(1), CARD11(5), CD72(1), CD79A(2), CD81(2), CR2(2), GSK3B(1), HRAS(4), IKBKB(1), INPP5D(3), KRAS(2), LYN(2), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAC1(1), RAC2(1), RAC3(2), SYK(2), VAV1(3), VAV2(3), VAV3(4)	53145233	92	67	89	40	28	13	14	21	16	0	0.762	1.000	1.000
477	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), CD81(2), CR2(2), DAG1(2), GRB2(1), GSK3A(3), GSK3B(1), INPP5D(3), ITPR1(4), ITPR2(8), ITPR3(6), LYN(2), MAP4K1(2), MAPK1(1), NFATC1(2), NFATC2(2), PDK1(2), PIK3CD(5), PIK3R1(2), PLCG2(3), PPP1R13B(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTPRC(8), RAF1(1), SHC1(3), SOS1(4), SOS2(1), SYK(2), VAV1(3)	52860187	91	67	90	35	29	14	7	22	19	0	0.575	1.000	1.000
478	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AKT1(3), AKT2(1), AKT3(1), APAF1(2), BIRC2(1), CAPN1(2), CAPN2(2), CASP10(1), CASP8(1), CASP9(1), CFLAR(2), CSF2RB(1), DFFA(4), FAS(1), FASLG(1), IKBKB(1), IL1A(1), IL1RAP(2), IL3RA(3), IRAK1(1), IRAK2(4), IRAK3(4), IRAK4(2), NFKB1(3), NTRK1(9), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RELA(3), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(1), TRAF2(5)	54404572	108	66	107	37	36	23	9	25	15	0	0.297	1.000	1.000
479	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(3), AKT2(1), AKT3(1), CASP8(1), CD14(2), CD40(1), CD86(1), CXCL9(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IKBKB(1), IKBKE(1), IL12A(1), IL12B(1), IL6(1), IRAK1(1), IRAK4(2), IRF3(1), IRF5(1), LY96(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K7(2), MAP3K8(1), MAPK1(1), MAPK12(1), MAPK13(1), NFKB1(3), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(3), RIPK1(1), STAT1(1), TBK1(1), TICAM1(1), TIRAP(1), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR7(3), TLR8(2), TLR9(1), TNF(1), TRAF6(2)	64474962	97	66	95	44	29	16	12	23	17	0	0.823	1.000	1.000
480	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(2), CD14(2), CD1B(3), CD1C(4), CD1D(1), CD1E(1), CD2(1), CD34(1), CD36(1), CD37(1), CD38(1), CD3D(1), CD4(1), CD8A(1), CD8B(2), CD9(1), CR1(1), CR2(2), CSF1(1), CSF1R(5), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(2), FLT3LG(1), GP5(4), GP9(1), HLA-DRA(1), HLA-DRB5(1), IL11RA(1), IL1A(1), IL1R2(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL7(2), IL7R(1), ITGA1(2), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGAM(3), KIT(3), MME(2), TFRC(1), THPO(1), TNF(1), TPO(5)	59849115	99	65	99	42	27	20	6	31	15	0	0.700	1.000	1.000
481	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(3), ACSL1(3), ACSL5(1), ACSL6(3), ADIPOQ(1), ADIPOR1(2), ADIPOR2(1), AKT1(3), AKT2(1), AKT3(1), CAMKK1(2), CD36(1), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), G6PC(1), G6PC2(1), IKBKB(1), IRS1(3), IRS2(2), IRS4(3), JAK1(6), JAK2(1), JAK3(1), LEPR(2), NFKB1(3), NFKBIB(2), NFKBIE(1), PCK2(2), POMC(2), PPARA(2), PPARGC1A(4), PRKAA2(5), PRKAG1(3), PRKAG3(1), PRKCQ(3), PTPN11(1), RELA(3), RXRA(2), RXRB(2), RXRG(2), SLC2A1(1), STAT3(6), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5), TYK2(2)	60970844	109	65	107	35	38	24	13	22	12	0	0.112	1.000	1.000
482	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(3), CREB1(1), DAXX(2), GRB2(1), HRAS(4), IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K11(1), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K8(1), MAP3K9(4), MAP4K1(2), MAP4K2(1), MAP4K4(1), MAP4K5(1), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(1), MEF2C(3), MEF2D(1), MYC(1), NFKB1(3), PAK1(1), PAK2(2), RAC1(1), RAF1(1), RELA(3), RIPK1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), RPS6KA5(3), RPS6KB2(2), SHC1(3), SP1(2), STAT1(1), TGFB2(2), TGFBR1(2), TRAF2(5)	68485902	106	64	104	39	33	20	15	18	19	1	0.450	1.000	1.000
483	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR3(1), AKT1(3), AKT2(1), AKT3(1), ANGPTL2(1), ARHGAP1(1), ARHGEF11(2), BTK(1), CFL1(1), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(8), ITPR3(6), LIMK1(2), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDK1(2), PIK3CD(5), PIK3CG(7), PIK3R1(2), PITX2(3), PPP1R13B(3), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(1), SAG(2), WASF1(2)	49380235	86	61	84	33	26	12	8	23	17	0	0.727	1.000	1.000
484	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(8), DLL1(3), DLL3(3), DLL4(2), DTX1(5), DTX2(2), DTX3L(2), DTX4(2), DVL1(1), DVL2(3), DVL3(1), EP300(7), HDAC1(1), HDAC2(1), JAG1(1), JAG2(4), LFNG(1), MAML1(1), MAML2(2), MAML3(1), MFNG(1), NCOR2(7), NCSTN(2), NOTCH1(6), NOTCH2(7), NOTCH3(4), NOTCH4(4), NUMB(1), NUMBL(1), PTCRA(1), RBPJ(1), RBPJL(1), SNW1(3)	50702534	90	60	90	37	33	14	9	15	18	1	0.626	1.000	1.000
485	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT1(3), AKT2(1), AKT3(1), CASP9(1), HRAS(4), KDR(7), KRAS(2), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NOS3(2), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), PRKCG(1), PTGS2(5), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SH2D2A(1), SHC2(1), SPHK1(1), SPHK2(1), VEGFA(2)	51245431	97	60	94	32	28	16	13	17	22	1	0.245	1.000	1.000
486	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK2(1), CLK3(3), COL2A1(1), CPSF1(1), CPSF2(1), CSTF2T(5), CSTF3(3), DDX1(1), DHX15(3), DHX16(2), DHX38(3), DHX8(2), DHX9(1), DICER1(1), METTL3(2), NONO(2), NXF1(1), PHF5A(1), POLR2A(6), PPM1G(2), PRPF3(1), PRPF4(2), PRPF4B(3), PRPF8(5), PSKH1(2), PTBP1(6), RBM17(1), RBM5(4), RNGTT(1), RNMT(4), SF3A1(3), SF3A2(2), SF3A3(1), SF3B1(4), SF3B4(1), SF3B5(1), SNRPA1(2), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPG(1), SNRPN(2), SRPK1(1), SRRM1(1), SUPT5H(3), U2AF1(1), U2AF2(1)	77047333	99	60	99	28	24	17	16	20	22	0	0.274	1.000	1.000
487	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(7), ASH2L(1), CARM1(2), CTCFL(1), DOT1L(4), EED(1), EHMT1(1), EHMT2(3), EZH1(2), EZH2(1), HCFC1(3), HSF4(1), JMJD4(1), MEN1(4), NSD1(4), OGT(1), PAXIP1(2), PPP1CA(1), PRDM2(4), PRDM9(4), PRMT1(1), PRMT5(2), PRMT7(1), PRMT8(1), RBBP5(2), SATB1(1), SETD1A(3), SETD2(10), SETD7(1), SETD8(1), SETDB1(2), SETDB2(1), SETMAR(1), SUV420H1(2), SUV420H2(1), WHSC1(7), WHSC1L1(4)	85326596	89	56	89	31	32	10	7	19	21	0	0.703	1.000	1.000
488	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(1), AK3(1), CAD(9), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), ENTPD1(1), ENTPD3(2), ENTPD4(2), ENTPD6(2), NME1(1), NME7(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3), PRIM2(2), RFC5(1), RRM2(1), TXNRD1(4), TYMS(1), UCK2(3), UMPS(3), UPP1(2), UPP2(1)	58970237	94	55	94	31	31	21	10	18	14	0	0.220	1.000	1.000
489	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AOC2(3), AOC3(1), AOX1(2), ASMT(2), CARM1(2), CAT(2), CYP1A1(1), CYP1A2(1), ECHS1(1), EHHADH(5), GCDH(1), HADH(3), HEMK1(1), HSD17B4(3), INMT(1), KMO(2), KYNU(3), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), NFX1(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), TDO2(1), TPH1(1), TPH2(2), WARS(1), WARS2(2)	44518359	68	54	68	28	18	11	8	19	11	1	0.771	1.000	1.000
490	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(14), B3GALT4(2), CDR1(1), DGKI(6), IL6ST(7), MRPL19(1), PIGK(1), RPL10(1), RPL11(4), RPL12(1), RPL19(2), RPL28(1), RPL29(1), RPL3(1), RPL34(1), RPL35A(1), RPL37(1), RPL3L(1), RPL5(3), RPL6(2), RPL7(2), RPL7A(1), RPL8(1), RPLP1(1), RPS10(1), RPS11(2), RPS20(1), RPS27A(2), RPS5(1), RPS6(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1), RPS6KB2(2), RPS9(1), SLC36A2(3), UBB(1), UBC(1)	38563595	78	52	78	42	22	19	6	17	14	0	0.992	1.000	1.000
491	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(3), ADCY6(2), ADCY8(7), CACNA1A(12), CACNA1B(3), GNAS(2), GNB1(1), GNB3(2), GRM4(2), ITPR3(6), KCNB1(4), PLCB2(1), PRKACA(2), PRKX(2), SCNN1B(4), SCNN1G(2), TAS1R2(4), TAS1R3(1), TAS2R13(1), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R5(1), TAS2R50(1), TRPM5(3)	41733569	73	51	73	32	34	7	8	16	8	0	0.725	1.000	1.000
492	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(10), AXIN1(1), CCND3(1), CSNK1E(3), DVL1(1), DVL2(3), DVL3(1), FZD1(2), FZD10(2), FZD2(4), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GSK3B(1), LDLR(3), MYC(1), PPP2R5E(2), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RAC1(1), RHOA(2), TCF7(1), WNT1(1), WNT2(2), WNT2B(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2)	43016709	78	51	77	35	25	12	8	18	15	0	0.601	1.000	1.000
493	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), CDS1(3), CDS2(1), CHAT(4), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), ESCO1(5), ESCO2(1), ETNK1(1), GNPAT(2), GPAM(2), GPD1L(1), GPD2(1), LCAT(1), NAT6(1), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2A(1), PPAP2B(1), PTDSS2(1), SH3GLB1(1)	47898875	73	48	73	26	17	12	8	18	18	0	0.548	1.000	1.000
494	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	BTK(1), CAD(9), CASP10(1), CASP8(1), DAXX(2), DEDD2(2), DFFA(4), EGFR(3), EPHB2(4), FAF1(4), IL1A(1), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAP3K5(2), MAPK1(1), MAPK8IP3(4), MET(4), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PFN1(1), PFN2(3), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(5), TNFRSF6B(1), TPX2(1), TRAF2(5), TUFM(1)	52825712	84	47	83	28	28	13	8	18	17	0	0.366	1.000	1.000
495	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CCNH(1), CDC25A(4), CDK7(2), CDKN1A(2), CDKN2A(1), CREB3L1(1), CREB3L3(1), CREB3L4(2), E2F1(3), E2F3(1), GBA2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MYC(1), MYT1(2), NACA(3), PCNA(2), POLA2(1), POLE(6), POLE2(1), RB1(3), RBL1(2), RPA1(2), RPA2(1), TFDP1(2), TFDP2(1), TNXB(12), WEE1(1)	51358623	77	46	77	29	24	15	7	17	13	1	0.505	1.000	1.000
496	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(3), AKT2(1), AKT3(1), CAB39(1), DDIT4(2), EIF4B(2), FIGF(1), HIF1A(2), MAPK1(1), PDPK1(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRKAA2(5), RICTOR(1), RPS6(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1), RPS6KB2(2), STK11(1), TSC1(2), TSC2(7), ULK1(1), ULK2(1), ULK3(2), VEGFA(2)	36263575	69	46	68	25	26	13	10	11	9	0	0.411	1.000	1.000
497	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	CPEB1(1), EGFR(3), ERBB2(6), ERBB4(4), ETS1(1), ETV6(1), FMN2(8), GRB2(1), KRAS(2), MAPK1(1), NOTCH1(6), NOTCH2(7), NOTCH3(4), NOTCH4(4), PIWIL1(7), PIWIL2(4), PIWIL3(2), RAF1(1), SOS1(4), SOS2(1)	37239314	68	46	68	27	21	14	7	14	12	0	0.613	1.000	1.000
498	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(2), ALPPL2(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(6), DDX41(4), DDX47(3), DDX50(4), DDX56(2), DHFR(2), ENTPD7(1), EP400(4), ERCC2(3), ERCC3(1), FPGS(1), MOV10L1(2), RAD54B(4), RAD54L(2), RUVBL2(3), SETX(6), SKIV2L2(4), SMARCA2(3), SMARCA5(3), SPR(1)	46297477	67	45	67	32	17	15	10	15	10	0	0.874	1.000	1.000
499	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), CDKN2A(1), DAPP1(1), GAB1(1), ITPR1(4), ITPR2(8), ITPR3(6), LYN(2), PDK1(2), PITX2(3), PLCG2(3), PPP1R13B(3), PREX1(1), PTPRC(8), RPS6KA1(2), RPS6KA2(2), SAG(2), SYK(2), TEC(1), VAV1(3)	38406391	63	45	62	26	14	12	6	21	10	0	0.750	1.000	1.000
500	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(3), BDKRB2(2), CALM1(1), CAV1(1), CHRNA1(1), FLT1(5), FLT4(4), KDR(7), NOS3(2), PDE2A(2), PDE3A(2), PDE3B(3), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKG1(1), RYR2(17), SLC7A1(1), SYT1(1), TNNI1(1)	29564467	62	44	61	26	25	12	4	11	9	1	0.482	1.000	1.000
501	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTR3(1), AKT1(3), ANGPTL2(1), CFL1(1), FLNA(1), FLNC(8), FSCN1(1), FSCN2(2), FSCN3(5), GDI1(1), LIMK1(2), MYH2(7), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PFN1(1), PFN2(3), RHO(1), ROCK1(5), ROCK2(1), WASF1(2)	35163980	66	44	64	29	26	11	5	18	6	0	0.710	1.000	1.000
502	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(2), BMP4(1), BMP5(4), BMP6(1), BMP7(3), BMP8B(1), BTRC(3), CSNK1A1L(1), CSNK1E(3), CSNK1G1(2), CSNK1G3(1), DHH(1), FBXW11(2), GLI1(5), GLI2(3), GLI3(3), GSK3B(1), HHIP(4), IHH(1), LRP2(5), PRKACA(2), PRKX(2), PTCH1(1), PTCH2(5), SHH(2), STK36(1), SUFU(1), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2)	44787036	76	43	76	29	27	18	10	12	9	0	0.257	1.000	1.000
503	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH4A1(2), AMD1(1), AOC2(3), AOC3(1), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(1), GLUD1(2), GOT1(2), GOT2(1), MAOA(2), MAOB(2), NOS1(3), NOS3(2), ODC1(1), OTC(1), P4HA1(4), P4HA2(3), P4HA3(3), P4HB(1), PYCR1(2)	32392593	59	42	58	24	18	10	5	18	8	0	0.743	1.000	1.000
504	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(2), ARHGDIB(1), BIRC2(1), CASP8(1), CASP9(1), CFLAR(2), DAXX(2), DFFA(4), GSN(6), LMNA(4), LMNB2(2), MAP2K7(4), MAP3K1(5), MAP3K5(2), MDM2(1), NFKB1(3), NUMA1(6), PAK2(2), PRKDC(11), PTK2(3), RASA1(1), RB1(3), RELA(3), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF2(5)	50774643	84	42	84	20	28	24	5	15	11	1	0.0349	1.000	1.000
505	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDH7A1(2), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), G6PC2(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHAL6A(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKL(2), PFKM(3), PFKP(3), PGAM2(1), PGK2(2), PGM3(1), PKLR(1)	42831659	72	42	71	19	23	11	10	15	13	0	0.0363	1.000	1.000
506	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(3), CREB1(1), DAXX(2), GRB2(1), HRAS(4), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP3K5(2), MAP3K7(2), MAP3K9(4), MAPKAPK5(1), MEF2A(1), MEF2C(3), MEF2D(1), MYC(1), PLA2G4A(4), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(3), STAT1(1), TGFB2(2), TGFBR1(2), TRAF2(5)	26838925	58	42	56	22	19	6	10	14	9	0	0.609	1.000	1.000
507	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(1), CAD(9), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), ENTPD1(1), NME1(1), NT5E(1), NT5M(1), POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1), RRM2(1), TXNRD1(4), TYMS(1), UCK2(3), UMPS(3), UPP1(2)	41621665	71	42	71	24	23	15	10	12	11	0	0.355	1.000	1.000
508	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(1), AASS(3), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), BBOX1(2), DOT1L(4), ECHS1(1), EHHADH(5), EHMT1(1), EHMT2(3), GCDH(1), HADH(3), HSD17B4(3), NSD1(4), PIPOX(2), PLOD1(2), PLOD3(3), RDH12(1), SETD1A(3), SETD7(1), SETDB1(2), SHMT1(1), SHMT2(1)	42583521	60	41	60	24	23	8	7	12	10	0	0.629	1.000	1.000
509	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), EGFR(3), GIT1(1), IGSF5(1), IKBKB(1), JAM2(1), LYN(2), MAP2K4(4), MAPK12(1), MAPK13(1), MET(4), NFKB1(3), NOD1(5), PAK1(1), PLCG1(1), PLCG2(3), PTPN11(1), RAC1(1), RELA(3), TCIRG1(1), TJP1(1)	51693008	63	41	63	25	16	13	7	19	8	0	0.634	1.000	1.000
510	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), DAG1(2), EPHB2(4), GRB2(1), ITPKB(2), LYN(2), MAPK1(1), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PI3(1), PIK3CD(5), PIK3R1(2), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(1), SHC1(3), SOS1(4), SOS2(1), SYK(2), VAV1(3)	37194596	57	41	56	30	24	10	4	9	10	0	0.910	1.000	1.000
511	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(2), EGF(3), EGFR(3), ETS1(1), HRAS(4), IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K5(2), MAPK1(1), MAPK13(1), NFKB1(3), PPP2CA(2), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), RAF1(1), RELA(3), RIPK1(1), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5)	36103983	62	40	60	26	16	13	9	16	8	0	0.664	1.000	1.000
512	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(1), AKT3(1), GRB2(1), GSK3A(3), GSK3B(1), IL4R(3), IRS1(3), IRS2(2), JAK1(6), JAK3(1), MAP4K1(2), MAPK1(1), PDK1(2), PIK3CD(5), PIK3R1(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(4), SOS2(1), STAT6(3)	25274162	52	39	51	21	16	7	3	12	14	0	0.720	1.000	1.000
513	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD28(2), CD3D(1), DAG1(2), EPHB2(4), GRB2(1), ITK(3), ITPKB(2), LCP2(2), MAPK1(1), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PLCG1(1), PTPRC(8), RAF1(1), RASGRP2(1), RASGRP4(1), SOS1(4), SOS2(1), VAV1(3), ZAP70(6)	41058046	63	39	63	26	29	10	5	11	8	0	0.701	1.000	1.000
514	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(3), GNAS(2), GNB1(1), GNGT1(1), GRB2(1), HRAS(4), IGF1R(4), KLK2(1), MAPK1(1), MYC(1), PDGFRA(3), PPP2CA(2), PTPRR(1), RAF1(1), RPS6KA1(2), RPS6KA5(3), SHC1(3), SOS1(4), STAT3(6)	24287253	44	38	42	17	11	5	8	15	5	0	0.659	1.000	1.000
515	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(2), ADRB1(1), CHRM2(2), CHRM3(1), CHRM4(3), DRD2(1), DRD3(2), DRD4(1), DRD5(1), HRH1(1), HRH2(1), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2)	18863510	45	37	44	21	23	7	2	9	4	0	0.547	1.000	1.000
516	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(4), F12(1), F13B(3), F2(2), F5(5), F7(2), F8(1), FGA(5), FGB(2), FGG(1), LPA(5), PLAT(3), PLG(1), SERPINB2(1), SERPINF2(1), VWF(6)	25947576	46	36	46	27	15	7	4	13	6	1	0.975	1.000	1.000
517	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(1), EPRS(4), GLUD1(2), GLUD2(2), GOT1(2), GOT2(1), NOS1(3), NOS3(2), OTC(1), P4HA1(4), P4HA2(3), P4HA3(3), PARS2(3), PYCR1(2), PYCR2(1), PYCRL(1), RARS2(1)	26349202	48	36	48	21	20	7	3	12	6	0	0.762	1.000	1.000
518	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), B3GALNT1(1), B3GALT2(2), B3GALT4(2), B3GALT5(3), B3GNT1(1), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT6(3), FUT1(1), FUT2(1), FUT3(2), FUT4(1), GBGT1(1), PIGA(1), PIGB(2), PIGC(1), PIGG(3), PIGH(1), PIGK(1), PIGO(2), PIGQ(3), PIGT(1), ST3GAL1(2), ST3GAL3(1), ST3GAL6(1), ST6GALNAC3(1), ST6GALNAC4(2), ST8SIA1(1), ST8SIA5(1)	35674533	60	36	60	23	22	9	8	14	6	1	0.615	1.000	1.000
519	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(5), ARHGEF11(2), ARHGEF5(4), BAIAP2(1), CFL1(1), DIAPH1(2), GSN(6), LIMK1(2), MYLK(4), PFN1(1), PIP5K1B(1), PPP1R12B(1), ROCK1(5), TLN1(4), VCL(1)	33093626	48	36	47	18	6	9	7	12	14	0	0.767	1.000	1.000
520	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(9), CPS1(4), EARS2(1), EPRS(4), GAD1(2), GAD2(9), GFPT2(2), GLUD1(2), GLUD2(2), GLUL(1), GNPNAT1(1), GOT1(2), GOT2(1), GSR(1), NADSYN1(1), NAGK(1), PPAT(1), QARS(1)	29114463	49	35	49	24	20	6	4	9	10	0	0.872	1.000	1.000
521	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDH7A1(2), AMDHD1(3), AOC2(3), AOC3(1), ASPA(1), CARM1(2), CNDP1(3), HAL(2), HARS(1), HDC(2), HEMK1(1), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), UROC1(3)	29070335	45	35	45	20	12	9	5	12	7	0	0.813	1.000	1.000
522	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(1), CFL1(1), CHN1(1), LIMK1(2), MAP3K1(5), MYLK(4), NCF2(3), PAK1(1), PDGFRA(3), PIK3R1(2), PLD1(3), PPP1R12B(1), RAC1(1), RALBP1(1), TRIO(7), VAV1(3), WASF1(2)	24100841	41	35	41	19	15	6	3	9	8	0	0.867	1.000	1.000
523	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), CALM1(1), CD79A(2), GRB2(1), HRAS(4), LYN(2), MAP3K1(5), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYK(2), SYT1(1), VAV1(3)	28120457	45	34	43	18	17	6	6	9	7	0	0.591	1.000	1.000
524	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGF(3), EGFR(3), GRB2(1), HRAS(4), JAK1(6), MAP2K4(4), MAP3K1(5), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6)	25950804	47	34	45	17	13	6	6	15	7	0	0.546	1.000	1.000
525	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(1), CHAT(4), CPT1B(2), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), ETNK1(1), GNPAT(2), GPD2(1), LCAT(1), LGALS13(1), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(1), PLCG1(1), PLCG2(3), PPAP2A(1), PPAP2B(1)	36472163	56	34	56	27	14	9	7	14	12	0	0.890	1.000	1.000
526	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(1), CRK(1), DOCK1(4), GAB1(1), GRB2(1), HGF(3), HRAS(4), ITGA1(2), MAP4K1(2), MAPK1(1), MET(4), PAK1(1), PIK3R1(2), PTK2(3), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(1), SOS1(4), STAT3(6)	30175965	45	34	43	20	13	6	10	9	7	0	0.720	1.000	1.000
527	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGTR1(3), ATF2(3), CALM1(1), EGFR(3), GRB2(1), HRAS(4), MAP2K4(4), MAP3K1(5), MAPK1(1), MEF2A(1), MEF2C(3), MEF2D(1), PAK1(1), PRKCA(2), PTK2(3), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYT1(1)	24540134	46	33	44	20	19	7	6	10	4	0	0.644	1.000	1.000
528	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(4), DIAPH1(2), FYN(1), GSN(6), HRAS(4), ITGA1(2), MAPK1(1), MYLK(4), PFN1(1), PIK3R1(2), PTK2(3), PXN(1), RAF1(1), ROCK1(5), SHC1(3), TLN1(4)	25986139	44	33	41	19	13	6	8	9	8	0	0.804	1.000	1.000
529	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), MCM10(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), NACA(3), PCNA(2), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), RFC1(5), RFC3(3), RFC5(1), RPA1(2), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1)	37310754	53	32	53	29	15	17	5	9	7	0	0.909	1.000	1.000
530	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN2(2), BCAR1(3), BCR(2), CAPN1(2), CAPNS1(2), CAV1(1), FYN(1), GRB2(1), HRAS(4), ITGA1(2), MAPK1(1), PPP1R12B(1), PTK2(3), PXN(1), RAF1(1), RAP1A(1), ROCK1(5), SHC1(3), SOS1(4), TLN1(4), VCL(1)	34680930	47	32	44	22	15	3	9	9	11	0	0.834	1.000	1.000
531	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CALM1(1), CAMK2A(1), CAMK2D(2), F2(2), FYN(1), GNA11(1), GNAI1(2), GNB1(1), GNGT1(1), GRB2(1), HRAS(4), JAK2(1), MAPK1(1), MYLK(4), PLCG1(1), PRKCA(2), RAF1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6), SYT1(1)	30689085	42	31	40	24	17	4	7	10	4	0	0.939	1.000	1.000
532	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ADCY3(2), ADCY9(5), ARF1(1), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(3), PRKCA(2), SEC61A1(1), SEC61A2(1)	27218153	40	31	40	19	11	5	4	13	7	0	0.823	1.000	1.000
533	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), CBL(1), CFLAR(2), E2F1(3), GRB2(1), HRAS(4), IL2RB(1), IRS1(3), JAK1(6), JAK3(1), MAPK1(1), MYC(1), NMI(1), PIK3R1(2), PPIA(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2), SYK(2)	24917838	43	31	40	17	14	7	5	6	11	0	0.600	1.000	1.000
534	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), GRB2(1), HRAS(4), IL6(1), IL6ST(7), JAK1(6), JAK2(1), JAK3(1), PTPN11(1), RAF1(1), SHC1(3), SOS1(4), STAT3(6)	17476763	37	31	35	14	8	8	6	6	9	0	0.619	1.000	1.000
535	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(2), ABAT(1), ACY3(1), ADSL(1), ADSS(1), AGXT(1), AGXT2(2), ASPA(1), ASRGL1(1), CAD(9), CRAT(1), DARS2(1), DDO(1), DLAT(1), DLD(2), GAD1(2), GAD2(9), GOT1(2), GOT2(1), NARS2(1), PC(2), PDHA1(1), PDHA2(4)	27836936	49	30	48	18	16	11	4	7	11	0	0.423	1.000	1.000
536	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(9), CPS1(4), EPRS(4), GAD1(2), GAD2(9), GLUD1(2), GLUL(1), GOT1(2), GOT2(1), NADSYN1(1), PPAT(1), QARS(1)	24486420	41	29	41	21	16	5	4	8	8	0	0.900	1.000	1.000
537	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CD4(1), CREBBP(8), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTPRC(8), ZAP70(6)	16932795	38	28	38	19	12	6	4	15	1	0	0.888	1.000	1.000
538	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CD4(1), CREBBP(8), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTPRC(8), ZAP70(6)	16932795	38	28	38	19	12	6	4	15	1	0	0.888	1.000	1.000
539	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASRGL1(1), CA1(1), CA12(1), CA13(1), CA14(2), CA2(3), CA3(1), CA4(2), CA5A(1), CA6(1), CA8(4), CA9(2), CPS1(4), CTH(2), GLUD1(2), GLUD2(2), GLUL(1), HAL(2)	15661324	34	28	34	12	9	9	1	10	5	0	0.480	1.000	1.000
540	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(1), AKT3(1), GRB2(1), IARS(2), IL13RA1(1), IL4(1), IL4R(3), INPP5D(3), JAK1(6), JAK2(1), JAK3(1), PI3(1), PPP1R13B(3), SERPINA4(1), SHC1(3), SOS1(4), SOS2(1), STAT6(3), TYK2(2)	25532837	42	28	41	19	13	7	5	9	8	0	0.764	1.000	1.000
541	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(3), AKT2(1), AKT3(1), BTK(1), CDKN2A(1), DAPP1(1), GRB2(1), GSK3A(3), GSK3B(1), IARS(2), IGFBP1(1), INPP5D(3), PDK1(2), PPP1R13B(3), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1), TEC(1), YWHAB(1), YWHAQ(2), YWHAZ(1)	24381799	42	28	41	15	12	6	3	11	10	0	0.482	1.000	1.000
542	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(4), DBH(5), GAD1(2), GAD2(9), HDC(2), MAOA(2), PAH(1), PNMT(1), SLC18A3(1), TPH1(1)	10553679	29	26	29	13	14	4	2	5	4	0	0.620	1.000	1.000
543	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(2), F2R(2), F3(1), F5(5), F7(2), FGA(5), FGB(2), FGG(1), PROC(3), PROS1(3), SERPINC1(2)	12120463	31	26	31	13	13	4	2	11	1	0	0.704	1.000	1.000
544	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(2), CAPNS1(2), EGF(3), EGFR(3), HRAS(4), ITGA1(2), MAPK1(1), MYLK(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTK2(3), PXN(1), TLN1(4)	23980892	39	26	37	21	11	3	6	15	4	0	0.942	1.000	1.000
545	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(1), ARF1(1), BTK(1), EEA1(4), GSK3A(3), GSK3B(1), LYN(2), PDPK1(1), PFKL(2), PFKM(3), PFKP(3), PLCG1(1), PRKCE(2), PRKCZ(3), RAC1(1), VAV2(3)	18420771	35	26	34	14	7	8	5	9	6	0	0.496	1.000	1.000
546	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(2), GNAI1(2), GNB1(1), GNGT1(1), HRAS(4), ITGA1(2), MAPK1(1), PLA2G4A(4), PLCB1(3), PRKCA(2), PTGS1(2), PTK2(3), RAF1(1), SYK(2), TBXAS1(2)	17978901	34	26	32	13	14	5	6	7	2	0	0.486	1.000	1.000
547	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	BTG1(1), CEBPB(1), CLOCK(1), CRY2(4), DNAJA1(1), EIF4G2(1), ETV6(1), GSTM3(1), GSTP1(1), HERPUD1(1), NCKAP1(1), NCOA4(3), NR1D2(2), PER1(4), PER2(4), PPP2CB(1), PSMA4(1), SF3A3(1), SUMO3(1), TOB1(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(2), ZFR(4)	25944674	41	25	41	15	10	6	3	12	10	0	0.762	1.000	1.000
548	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(3), C6(5), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGAL(5), ITGB2(2), SELP(4), SELPLG(2), TNF(1), VCAM1(2)	18290146	33	25	32	17	15	4	6	6	2	0	0.739	1.000	1.000
549	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM1(1), CREB1(1), GNAI1(2), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), RAF1(1), SYT1(1)	25614852	37	24	35	18	11	2	7	13	4	0	0.898	1.000	1.000
550	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), HAL(2), HARS(1), HDC(2), MAOA(2), MAOB(2)	17915603	30	24	29	12	8	6	3	8	5	0	0.737	1.000	1.000
551	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), ALDH18A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AMD1(1), AOC2(3), AOC3(1), ARG1(1), ARG2(1), CPS1(4), MAOA(2), MAOB(2), NAGS(1), ODC1(1), OTC(1), SRM(1)	21566731	30	24	30	13	7	7	2	10	4	0	0.761	1.000	1.000
552	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(5), GNA13(2), GNB1(1), GNGT1(1), MYLK(4), PLCB1(3), PPP1R12B(1), PRKCA(2), ROCK1(5)	15254702	28	24	27	12	5	6	4	11	2	0	0.783	1.000	1.000
553	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), CDK7(2), ERCC3(1), GTF2E1(1), GTF2E2(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3B(3), POLR3D(1), TAF13(1), TAF5(1), TAF6(1)	25804357	33	24	33	21	8	6	5	10	4	0	0.974	1.000	1.000
554	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(1), ADSS(1), AGXT(1), AGXT2(2), ASPA(1), CAD(9), CRAT(1), DDO(1), GAD1(2), GAD2(9), GOT1(2), GOT2(1), PC(2)	19191428	35	23	35	15	13	5	4	5	8	0	0.674	1.000	1.000
555	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), CYP7A1(1), HADHB(1), SOAT2(3)	17111136	29	23	28	13	7	3	6	7	6	0	0.738	1.000	1.000
556	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(3), GHR(1), GRB2(1), HRAS(4), IRS1(3), JAK2(1), MAPK1(1), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RPS6KA1(2), SHC1(3), SOS1(4), STAT5B(2)	22787669	31	23	29	12	12	5	5	4	5	0	0.561	1.000	1.000
557	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(1), GPRC5B(1), GPRC5C(1), GRM1(9), GRM2(2), GRM3(4), GRM4(2), GRM5(5), GRM7(2), GRM8(2)	15500182	32	23	31	14	19	2	2	4	5	0	0.511	1.000	1.000
558	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(1), GALNT10(5), GALNT11(2), GALNT12(2), GALNT13(1), GALNT14(3), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GALNTL5(3), GCNT1(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(2), ST6GALNAC1(1), WBSCR17(2)	23806767	36	23	36	16	14	4	2	11	5	0	0.790	1.000	1.000
559	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IKBKB(1), IL1A(1), IL1RAP(2), IL6(1), IRAK1(1), IRAK2(4), IRAK3(4), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAP3K7(2), NFKB1(3), RELA(3), TGFB2(2), TNF(1), TRAF6(2)	21719886	35	23	35	16	13	8	3	5	6	0	0.683	1.000	1.000
560	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(2), DAG1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), NFAT5(1), PDE6B(2), PDE6C(1), PDE6D(1), SLC6A13(3), TF(1)	26309900	34	23	34	16	11	6	2	9	6	0	0.817	1.000	1.000
561	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(8), APOA4(2), APOC1(1), APOE(2), CETP(2), CYP7A1(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(3), LIPC(1), LPL(1), LRP1(12), SCARB1(2)	20196690	38	23	38	16	15	9	4	4	6	0	0.466	1.000	1.000
562	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CYP7A1(1), HADHB(1), RDH12(1), SLC27A5(2), SOAT2(3)	23223527	28	22	28	14	7	3	5	8	5	0	0.844	1.000	1.000
563	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(8), EP300(7), FYN(1), IL7(2), IL7R(1), JAK1(6), JAK3(1), NMI(1), PIK3R1(2), STAT5B(2)	18888567	31	22	31	15	6	6	3	9	7	0	0.901	1.000	1.000
564	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(3), EGFR(3), GRB2(1), HRAS(4), MAPK1(1), PTPRB(5), RAF1(1), RASA1(1), SHC1(3), SOS1(4), SPRY3(1)	18407053	28	22	26	12	10	2	4	9	3	0	0.770	1.000	1.000
565	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), CD38(1), ENPP1(3), ENPP3(2), NADK(1), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT12(3)	15883813	24	21	24	10	6	5	1	6	6	0	0.688	1.000	1.000
566	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG(2), POLG2(1), POLI(1), POLL(1), POLM(1), POLQ(6), PRIM2(2), REV1(2), REV3L(5), RFC5(1)	29843113	36	21	36	14	8	10	3	7	8	0	0.778	1.000	1.000
567	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	GRB2(1), HRAS(4), JAK2(1), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6), STAT5B(2), THPO(1)	20518367	30	21	28	11	10	5	5	5	5	0	0.491	1.000	1.000
568	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), CFL1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), LIMK1(2), MAPK1(1), PIK3C2G(1), PLCB1(3), PPP1R12B(1), PRKCA(2), PTK2(3), RAF1(1), ROCK2(1)	18407445	26	20	24	13	7	3	4	9	3	0	0.936	1.000	1.000
569	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C8B(2), C9(3), MASP1(2)	15309765	27	20	27	12	11	2	3	5	6	0	0.695	1.000	1.000
570	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(5), ATR(3), CCNA1(1), CDC25A(4), CDKN1A(2), CDKN2A(1), DHFR(2), E2F1(3), GSK3B(1), HDAC1(1), RB1(3), TFDP1(2), TGFB2(2)	16803197	30	20	30	12	8	4	6	1	10	1	0.731	1.000	1.000
571	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	GRB2(1), HRAS(4), IL2RB(1), JAK1(6), JAK3(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2), SYK(2)	16980318	25	20	23	16	8	4	5	2	6	0	0.917	1.000	1.000
572	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(2), GNAI1(2), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), MAPK1(1), MYT1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RPS6KA1(2)	15085400	25	20	23	10	7	2	6	10	0	0	0.727	1.000	1.000
573	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(8), EP300(7), HDAC3(2), IKBKB(1), NFKB1(3), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2)	16426930	30	20	30	13	9	9	4	6	2	0	0.636	1.000	1.000
574	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), CASP8(1), CFLAR(2), MAP2K4(4), MAP3K3(1), MAP3K7(2), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5)	19984934	29	20	29	11	9	7	1	8	4	0	0.560	1.000	1.000
575	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C9(3), MASP1(2), MASP2(2)	15673730	27	19	27	13	10	2	4	6	5	0	0.737	1.000	1.000
576	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(3), CRK(1), GNAI1(2), GNB1(1), GNGT1(1), HRAS(4), MAPK1(1), NFKB1(3), PIK3C2G(1), PIK3R1(2), PLCG1(1), PRKCA(2), PTK2(3), PXN(1), RAF1(1), RELA(3)	18581570	30	19	28	12	9	5	6	6	4	0	0.660	1.000	1.000
577	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(4), F2(2), F2RL1(1), MAPK1(1), PLD1(3), PLD2(2), PTK2(3), RAF1(1), RASAL1(3), TEC(1), VAV1(3)	20176408	28	19	28	13	14	3	1	7	3	0	0.806	1.000	1.000
578	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8)	7934954	21	19	20	10	8	3	3	5	2	0	0.634	1.000	1.000
579	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGTR1(3), CMA1(2), COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4)	18336944	24	18	24	11	6	6	1	6	5	0	0.806	1.000	1.000
580	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), EDNRA(1), EGF(3), EGFR(3), HRAS(4), MYC(1), NFKB1(3), PLCG1(1), PRKCA(2), RELA(3)	15140155	24	18	22	12	6	3	4	10	1	0	0.831	1.000	1.000
581	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(4), F2(2), F2R(2), FGA(5), FGB(2), FGG(1), PLAT(3), PLG(1), SERPINB2(1)	9886796	22	18	22	18	11	2	1	8	0	0	0.993	1.000	1.000
582	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(1), IL22RA2(1), JAK1(6), JAK2(1), JAK3(1), STAT1(1), STAT3(6), STAT5B(2), TYK2(2)	13497691	23	18	23	10	1	5	3	8	6	0	0.752	1.000	1.000
583	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD4(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8)	8322645	21	18	20	10	8	3	3	6	1	0	0.670	1.000	1.000
584	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PPP2CA(2), PRKAA2(5), PRKAG1(3), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	11280071	23	17	23	10	5	4	3	10	1	0	0.821	1.000	1.000
585	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(3), GLB1(2), HEXB(2), LCT(6), SLC33A1(1), ST3GAL1(2), ST6GALNAC3(1), ST6GALNAC4(2), ST8SIA1(1), ST8SIA5(1)	12179707	23	17	23	15	12	3	2	4	2	0	0.925	1.000	1.000
586	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(1), AGTR1(3), ANPEP(2), CMA1(2), CPA3(1), CTSG(2), ENPEP(2), LNPEP(1), MAS1(1), MME(2), THOP1(2)	15576086	23	17	22	14	7	7	2	6	1	0	0.904	1.000	1.000
587	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB1(1), EEF2K(5), EIF4E(1), GRB2(1), MAP3K8(1), MAPK1(1), MOS(1), NFKB1(3), RAP1A(1), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1)	20623532	27	17	27	11	12	7	2	3	3	0	0.471	1.000	1.000
588	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C9(3)	12875060	23	16	23	11	9	2	3	4	5	0	0.726	1.000	1.000
589	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL4(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(3), TLR9(1)	13743026	19	16	18	12	5	3	1	7	3	0	0.880	1.000	1.000
590	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(2), ACO1(1), ACO2(1), CS(3), DLD(2), FH(3), IDH3A(1), IDH3B(1), MDH1(1), PC(2), PCK2(2), SDHA(3), SDHB(2), SDHC(2), SUCLA2(1)	21366053	27	16	27	14	4	6	5	5	7	0	0.790	1.000	1.000
591	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(4), DHCR24(2), DHCR7(1), EBP(1), GGCX(2), HMGCR(1), HSD17B7(2), IDI2(2), LSS(2), MVK(1), NQO1(2), SQLE(1), TM7SF2(1)	14064383	22	16	21	10	9	5	2	2	4	0	0.649	1.000	1.000
592	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	GRB2(1), HRAS(4), IRS1(3), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(1), SHC1(3), SOS1(4)	17069484	20	16	18	10	10	1	4	1	4	0	0.808	1.000	1.000
593	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CALM1(1), CAPN2(2), CAPNS1(2), EP300(7), HDAC1(1), HDAC2(1), MEF2D(1), NFATC1(2), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), SYT1(1)	17964790	28	16	28	13	10	3	3	9	3	0	0.783	1.000	1.000
594	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IL1A(1), IRAK1(1), MAP3K1(5), MAP3K7(2), NFKB1(3), RELA(3), RIPK1(1), TLR4(2), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2)	17746240	25	16	25	12	9	7	2	3	4	0	0.678	1.000	1.000
595	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP4K2(1), NFKB1(3), RELA(3), RIPK1(1), TANK(1), TNF(1), TNFRSF1A(1), TRAF2(5)	17605880	28	16	28	11	9	7	3	6	3	0	0.503	1.000	1.000
596	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(8), EP300(7), NCOA3(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RARA(1), RXRA(2)	15259656	29	15	29	13	10	4	6	8	1	0	0.687	1.000	1.000
597	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2E1(1), HDAC3(2), NCOA1(1), NCOA2(2), NCOA3(1), NCOR2(7), POLR2A(6), RARA(1), RXRA(2)	18282376	24	15	24	22	9	6	2	4	3	0	0.995	1.000	1.000
598	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4), P4HB(1), SLC23A2(1), SLC2A1(1)	18189682	21	14	21	10	8	5	0	3	5	0	0.800	1.000	1.000
599	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(2), CAPN1(2), CAPNS1(2), ITGA1(2), PTK2(3), PXN(1), RAC1(1), SPTAN1(2), TLN1(4)	21023448	21	13	21	13	8	1	2	5	5	0	0.948	1.000	1.000
600	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2E1(1), GTF2E2(1), GTF2H3(2), GTF2H4(1), STON1(1), TAF1(2), TAF13(1), TAF2(1), TAF4(1), TAF5(1), TAF5L(3), TAF6(1), TAF7L(3)	23834473	19	12	19	14	6	4	4	4	1	0	0.980	1.000	1.000
601	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(1), CASP1(2), CASP8(1), GAPDH(1), ITCH(2), MAGI1(2), MAGI2(2), RERE(3), WWP1(3), WWP2(1)	17695052	19	12	19	10	4	3	3	4	5	0	0.884	1.000	1.000
602	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT7(2), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(1), CHST4(1), FUT8(2), ST3GAL1(2), ST3GAL3(1)	9169239	17	11	17	9	9	3	2	3	0	0	0.833	1.000	1.000
603	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(3), ITGAL(5), ITGB2(2), SELE(1)	8900916	12	11	11	7	6	0	3	3	0	0	0.811	1.000	1.000
604	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(3), HRAS(4), KLK2(1), MAPK1(1), RAF1(1)	6045731	10	10	8	11	4	0	4	1	1	0	0.996	1.000	1.000
605	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(2), KHK(1), LCT(6), MPI(1), PYGL(4), PYGM(1)	9842043	15	10	14	10	9	2	0	3	1	0	0.883	1.000	1.000
606	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PRKACA(2), PRKAR1A(2)	4843467	10	10	10	7	2	1	0	7	0	0	0.985	1.000	1.000
607	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), LPO(2), MPO(3), TPO(5)	6131553	14	10	14	6	8	2	0	4	0	0	0.597	1.000	1.000
608	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CSF1(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(3), TNFSF8(2)	9555858	16	10	16	10	6	4	3	2	1	0	0.831	1.000	1.000
609	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2)	7054909	14	9	14	8	4	1	1	8	0	0	0.937	1.000	1.000
610	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), CFTR(3), GNAS(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1)	9596071	14	9	14	8	4	3	1	6	0	0	0.920	1.000	1.000
611	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(5), JUND(2)	2756375	8	8	8	6	3	2	1	2	0	0	0.932	1.000	1.000
612	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5)	6108195	10	7	10	6	4	3	1	2	0	0	0.768	1.000	1.000
613	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CCR5(2), PLCG1(1), PRKCA(2), SYT1(1)	10139044	7	6	7	5	4	1	0	2	0	0	0.873	1.000	1.000
614	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), EIF4E(1), LDHB(1), LDHC(1), NCL(1)	6599531	6	4	6	4	1	3	1	1	0	0	0.819	1.000	1.000
615	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	533210	1	1	1	2	1	0	0	0	0	0	0.977	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		1268227	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
