rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(10), CDKN2A(17), E2F1(4), MDM2(8), MYC(6), PIK3CA(80), PIK3R1(12), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), RAC1(1), RB1(14), TBX2(10), TP53(200), TWIST1(3)	11920579	400	265	261	39	100	58	65	60	112	5	<1.00e-15	<1.00e-15	<1.03e-13
2	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(49), ATR(28), BRCA1(16), BRCA2(39), CHEK1(6), CHEK2(10), FANCA(12), FANCC(6), FANCD2(14), FANCE(6), FANCF(1), FANCG(4), HUS1(2), MRE11A(7), RAD1(2), RAD17(6), RAD50(12), RAD51(1), RAD9A(5), TP53(200), TREX1(4)	25906136	430	254	328	43	96	51	49	71	153	10	1.26e-12	<1.00e-15	<1.03e-13
3	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(10), ATM(49), BRCA1(16), CDKN1A(5), CHEK1(6), CHEK2(10), JUN(5), MAPK8(6), MDM2(8), MRE11A(7), NFKB1(8), NFKBIA(1), RAD50(12), RAD51(1), RBBP8(5), RELA(7), TP53(200), TP73(6)	17491262	362	248	262	38	86	42	40	60	128	6	1.31e-11	<1.00e-15	<1.03e-13
4	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(33), AKT1(3), ATM(49), BAX(1), CDKN1A(5), CPB2(10), CSNK1A1(5), CSNK1D(4), FHL2(2), HIC1(10), HIF1A(5), HSPA1A(4), IGFBP3(5), MAPK8(6), MDM2(8), NFKBIB(8), NQO1(3), TP53(200)	12175875	361	248	265	32	95	48	36	61	115	6	<1.00e-15	<1.00e-15	<1.03e-13
5	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(9), MAX(3), MYC(6), SP1(5), SP3(5), TP53(200), WT1(5)	4140585	233	206	143	11	68	28	23	35	77	2	<1.00e-15	<1.00e-15	<1.03e-13
6	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(5), DNAJC3(3), EIF2S1(2), EIF2S2(3), NFKB1(8), NFKBIA(1), RELA(7), TP53(200)	5730250	229	200	141	10	62	26	23	39	77	2	<1.00e-15	<1.00e-15	<1.03e-13
7	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(5), CCND1(2), CDK2(4), CDK4(2), CDKN1A(5), CDKN1B(1), CDKN2A(17), CFL1(1), E2F1(4), E2F2(5), MDM2(8), NXT1(3), PRB1(3), TP53(200)	4941636	260	213	168	17	73	34	26	39	84	4	<1.00e-15	1.67e-15	1.47e-13
8	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(8), ATM(49), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), CASP3(2), CASP6(1), CASP7(4), CASP9(3), EIF2S1(2), PRKCA(8), PTK2(11), PXN(6), STAT1(11), TLN1(28), TP53(200)	16068160	348	244	253	28	102	47	35	53	106	5	<1.00e-15	2.22e-15	1.64e-13
9	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(49), ATR(28), CDC25C(11), CHEK1(6), CHEK2(10), TP53(200), YWHAH(3)	9392938	307	232	211	22	78	32	33	51	107	6	9.74e-12	2.44e-15	1.64e-13
10	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(5), HSPA1A(4), IFNG(2), IFNGR1(10), IFNGR2(2), IKBKB(10), JAK2(12), LIN7A(9), NFKB1(8), NFKBIA(1), RB1(14), RELA(7), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TP53(200), USH1C(8), WT1(5)	10636090	309	226	219	41	83	39	32	54	98	3	4.05e-10	2.66e-15	1.64e-13
11	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(49), CDC25A(5), CDC25B(6), CDC25C(11), CDK2(4), CDK4(2), CHEK1(6), MYT1(22), RB1(14), TP53(200), WEE1(6), YWHAH(3)	10343333	328	238	233	25	82	40	35	58	107	6	1.68e-14	3.11e-15	1.74e-13
12	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(46), DAXX(11), HRAS(1), PAX3(14), PML(16), RARA(4), RB1(14), SIRT1(8), SP100(19), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TP53(200)	11157095	345	228	252	40	105	40	43	50	105	2	1.11e-13	4.00e-15	2.05e-13
13	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(8), ATM(49), BAX(1), BCL2(4), CCND1(2), CCNE1(5), CDK2(4), CDK4(2), CDKN1A(5), E2F1(4), MDM2(8), PCNA(2), RB1(14), TIMP3(10), TP53(200)	10653159	318	237	221	24	80	40	36	52	103	7	3.22e-15	4.44e-15	2.10e-13
14	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(8), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CASP2(3), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), FADD(3), FAS(3), FASLG(5), GZMB(2), JUN(5), MAP2K4(9), MAP3K1(16), MAPK10(4), MCL1(2), MDM2(8), MYC(6), NFKB1(8), NFKBIA(1), PARP1(13), PRF1(13), RELA(7), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(9), TP53(200), TRADD(2), TRAF1(4), TRAF2(4)	21906316	407	251	305	56	106	50	41	69	136	5	7.67e-12	3.57e-14	1.57e-12
15	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(10), ATM(49), ATR(28), CCNA1(10), CCND1(2), CCNE1(5), CDC25A(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2A(17), CDKN2B(1), E2F1(4), GSK3B(6), HDAC1(9), RB1(14), SKP2(6), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9), TP53(200)	17737262	408	254	310	64	98	49	46	71	138	6	8.23e-08	1.52e-08	6.23e-07
16	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(49), ATR(28), BRCA1(16), CCNB1(3), CDC25A(5), CDC25B(6), CDC25C(11), CDC34(2), CDKN1A(5), CDKN2D(4), CHEK1(6), CHEK2(10), EP300(27), MDM2(8), MYT1(22), PRKDC(56), RPS6KA1(9), TP53(200), WEE1(6), YWHAH(3), YWHAQ(4)	24559677	480	261	376	69	127	56	63	83	144	7	4.81e-11	5.27e-07	2.03e-05
17	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(23), HLA-A(22), IL18(1), ITGB1(11), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), LAT(3), MAP2K1(7), MAPK3(3), PAK1(5), PIK3CA(80), PIK3R1(12), PTK2B(16), PTPN6(6), RAC1(1), SYK(9), VAV1(13)	10927188	230	123	164	22	39	46	43	39	56	7	1.10e-10	3.34e-06	0.000121
18	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(14)	424734	14	14	12	1	5	1	2	1	5	0	0.0724	9.52e-05	0.00326
19	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(10), CDKN1B(1), GRB2(4), ILK(9), ITGB1(11), MAPK1(3), MAPK3(3), PDK2(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PTEN(36), PTK2(11), SHC1(7), SOS1(9)	11291315	201	118	142	20	38	36	40	36	47	4	1.90e-09	0.000338	0.0104
20	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(4), CDC42(3), DLD(10), DUSP10(8), DUSP4(2), DUSP8(2), GAB1(4), GCK(9), IL1R1(4), JUN(5), MAP2K4(9), MAP2K5(1), MAP2K7(38), MAP3K1(16), MAP3K10(13), MAP3K11(9), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K7(11), MAP3K9(5), MAPK10(4), MAPK7(8), MAPK8(6), MAPK9(5), MYEF2(8), NFATC3(5), NR2C2(6), PAPPA(29), SHC1(7), TP53(200), TRAF6(6), ZAK(8)	29514100	526	258	427	83	158	71	59	82	151	5	3.38e-12	0.000339	0.0104
21	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(80), PIK3R1(12), PLCB1(21), PLCG1(22), PRKCA(8), VAV1(13)	7542730	159	100	109	17	38	36	37	23	24	1	5.73e-09	0.000580	0.0170
22	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(8), BAD(4), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BCL2L11(4), BID(2), BIRC2(7), BIRC3(10), BIRC5(3), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CHUK(5), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), GZMB(2), HELLS(7), IKBKB(10), IRF1(5), IRF2(24), IRF3(3), IRF4(8), IRF5(6), IRF6(8), IRF7(4), JUN(5), LTA(4), MAP2K4(9), MAP3K1(16), MAPK10(4), MDM2(8), MYC(6), NFKB1(8), NFKBIA(1), NFKBIB(8), NFKBIE(1), PLEKHG5(9), PRF1(13), RELA(7), RIPK1(3), TNF(3), TNFRSF10B(2), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(4), TNFRSF25(5), TNFSF10(9), TP53(200), TP73(6), TRADD(2), TRAF1(4), TRAF2(4), TRAF3(7)	33599531	554	272	447	91	149	68	62	94	176	5	1.69e-11	0.00404	0.113
23	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(2), CD80(5), CD86(7), CTLA4(4), GRB2(4), HLA-DRA(7), HLA-DRB1(1), ICOS(4), ITK(5), LCK(4), PIK3CA(80), PIK3R1(12), PTPN11(8)	7523533	144	97	95	16	30	32	38	24	19	1	1.24e-07	0.00423	0.113
24	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(8), AKT1(3), ANXA1(6), CALM1(2), CALM2(3), CALM3(1), GNAS(38), GNB1(2), GNGT1(3), NFKB1(8), NOS3(15), NPPA(2), NR3C1(9), PIK3CA(80), PIK3R1(12), RELA(7), SYT1(5)	10506382	204	123	149	26	58	36	39	39	31	1	1.03e-07	0.0199	0.512
25	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), BAD(4), CASP9(3), CHUK(5), GH1(2), GHR(9), NFKB1(8), NFKBIA(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PPP2CA(4), RELA(7), YWHAH(3)	8259425	142	94	96	18	24	37	38	25	17	1	3.11e-07	0.0235	0.580
26	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), BCL2(4), EGFR(19), IGF1R(20), MYC(6), POLR2A(24), PPP2CA(4), PRKCA(8), RB1(14), TEP1(37), TERF1(8), TERT(9), TNKS(21), TP53(200), XRCC5(10)	16541878	387	235	293	77	109	51	53	60	112	2	4.77e-07	0.0286	0.678
27	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), BAD(4), BCL2L1(1), CASP9(3), CDC42(3), CHUK(5), ELK1(4), HRAS(1), MAP2K1(7), MAPK3(3), NFKB1(8), PIK3CA(80), PIK3R1(12), RAC1(1), RAF1(9), RALBP1(10), RALGDS(14), RELA(7), RHOA(20)	11177540	195	119	140	28	43	44	44	35	28	1	4.95e-08	0.0311	0.710
28	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), GRB2(4), HRAS(1), KLK2(1), NTRK1(9), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), SHC1(7), SOS1(9)	9147566	156	101	108	20	38	35	37	25	20	1	1.54e-07	0.0364	0.800
29	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(8), ATM(49), ATR(28), BAI1(20), BAX(1), BID(2), CASP3(2), CASP8(18), CASP9(3), CCNB1(3), CCNB3(21), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNG2(1), CD82(3), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN2A(17), CHEK1(6), CHEK2(10), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(5), IGF1(2), IGFBP3(5), MDM2(8), MDM4(4), PERP(3), PPM1D(9), PTEN(36), RCHY1(1), RFWD2(8), RPRM(6), RRM2(3), RRM2B(4), SERPINB5(3), SERPINE1(3), SESN1(2), SESN2(2), SESN3(5), SFN(1), SIAH1(3), STEAP3(9), THBS1(17), TNFRSF10B(2), TP53(200), TP53I3(1), TP73(6), TSC2(14), ZMAT3(4)	38258894	593	290	478	104	157	70	64	109	183	10	2.00e-09	0.0677	1.000
30	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(3), AKT1(3), AKT2(10), AKT3(8), APAF1(8), ATM(49), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CAPN1(7), CAPN2(10), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CFLAR(1), CHUK(5), CSF2RB(12), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(5), IRAK1(7), IRAK2(11), IRAK3(9), IRAK4(3), MYD88(4), NFKB1(8), NFKB2(9), NFKBIA(1), NTRK1(9), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RELA(7), RIPK1(3), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(9), TP53(200), TRADD(2), TRAF2(4)	48899408	787	298	623	123	206	114	99	134	225	9	<1.00e-15	0.110	1.000
31	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(5), CDC34(2), CDK2(4), CUL1(24), E2F1(4), FBXW7(32), RB1(14), TFDP1(5)	4857435	90	64	78	11	29	9	14	10	28	0	7.65e-05	0.133	1.000
32	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), KLK2(1), MAP2K1(7), MAPK3(3), MAPK8(6), NGFR(7), PIK3CA(80), PIK3R1(12), PLCG1(22), RAF1(9), SHC1(7), SOS1(9)	11214607	183	107	132	25	46	38	39	33	26	1	4.74e-08	0.142	1.000
33	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(10), FMOD(12), KERA(5), LUM(8)	2129598	36	29	36	4	14	2	4	12	4	0	0.0127	0.160	1.000
34	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(9), ERBB4(59), NRG2(9), NRG3(24), PRKCA(8), PSEN1(5)	5281109	114	80	103	22	27	13	22	31	21	0	0.0173	0.193	1.000
35	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(7), GRIA2(26), JUND(2), PPP1R1B(3)	2191409	41	34	41	7	8	9	6	11	7	0	0.0317	0.209	1.000
36	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(4), LIPT1(5)	895003	9	9	8	1	2	3	1	0	2	1	0.207	0.416	1.000
37	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(10), AOC3(13), CES1(16), ESD(1)	3537071	40	35	38	4	11	3	3	9	14	0	0.0597	0.522	1.000
38	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(7), GSTZ1(2), HGD(6)	1306926	15	15	13	3	4	0	3	4	4	0	0.398	0.529	1.000
39	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(6), GH1(2), GHR(9), HRAS(1), IGF1(2), IGF1R(20), PIK3CA(80), PIK3R1(12), SHC1(7), SOD2(2), SOD3(1)	7807677	145	93	99	29	26	38	39	24	17	1	0.000181	0.672	1.000
40	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(4), EIF4G1(25), EIF4G3(22), GHR(9), IRS1(27), MAPK1(3), MAPK14(2), MAPK3(3), MKNK1(5), PABPC1(10), PDK2(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PRKCA(8), PTEN(36), RPS6KB1(6)	16509284	268	136	204	34	48	51	50	42	71	6	2.26e-08	0.674	1.000
41	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(3), SEC61A2(4), SRP19(3), SRP54(6), SRP68(6), SRP72(14), SRP9(2), SRPR(16)	4424708	54	42	52	5	15	7	10	5	17	0	0.00309	0.675	1.000
42	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(3), TGDS(5), UGDH(8), UXS1(8)	2256701	25	22	25	3	9	2	6	4	4	0	0.0333	0.688	1.000
43	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(3)	965217	9	9	9	2	4	2	1	1	1	0	0.360	0.704	1.000
44	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(53), CDH1(33), CREBBP(46), EP300(27), MAP2K1(7), MAP3K7(11), MAPK3(3), SKIL(7), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17)	15063845	233	137	212	42	49	25	36	45	74	4	0.000507	0.779	1.000
45	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(1), ALDOB(9), ALDOC(7), TPI1(3)	2295817	26	25	26	4	6	7	3	6	4	0	0.0607	0.784	1.000
46	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), FDPS(12), IDI1(2), SQLE(9)	1868455	26	19	25	3	7	3	3	4	9	0	0.0499	0.785	1.000
47	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(3), TGDS(5), UGDH(8), UGP2(9), UXS1(8)	2875221	34	27	33	4	11	2	6	6	9	0	0.0275	0.785	1.000
48	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(4), CASP3(2), CASP8(18), CFL1(1), CFLAR(1), PDE6D(1)	2273778	27	23	24	5	3	5	4	3	12	0	0.329	0.842	1.000
49	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), PAK1(5), PDGFRA(13), PIK3CA(80), PIK3R1(12), RAC1(1), WASL(5)	7868033	134	89	88	25	18	34	38	20	23	1	0.000697	0.861	1.000
50	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(5), CDK2(4), CDKN1B(1), CKS1B(2), CUL1(24), E2F1(4), RB1(14), RBX1(1), SKP2(6), TFDP1(5), UBE2M(1)	5045457	67	49	67	10	10	9	14	11	23	0	0.00671	0.867	1.000
51	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), FDPS(12), GGPS1(4), IDI1(2), IDI2(3), SQLE(9)	2503359	33	22	32	4	8	4	3	6	12	0	0.0438	0.892	1.000
52	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(10), AKT3(8), BPNT1(6), GRB2(4), ILK(9), MAPK1(3), MAPK3(3), PDK1(3), PIK3CA(80), PIK3CD(15), PTEN(36), PTK2B(16), RBL2(7), SHC1(7), SOS1(9)	11979562	219	121	161	33	52	43	37	38	46	3	4.70e-06	0.894	1.000
53	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(4), CALM1(2), CALM2(3), CALM3(1), ELK1(4), FCER1A(5), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP2K1(7), MAP2K4(9), MAP2K7(38), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PAK2(12), PIK3CA(80), PIK3R1(12), PLA2G4A(7), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), RAF1(9), SHC1(7), SOS1(9), SYK(9), SYT1(5), VAV1(13)	25251022	392	164	332	56	124	65	61	57	80	5	4.82e-14	0.915	1.000
54	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(6), CCL2(1), CSF1(5), LDLR(12), LPL(9)	3127094	33	30	31	6	10	4	3	4	12	0	0.0688	0.925	1.000
55	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(8), ARHGAP5(26), ARHGDIB(1), CASP1(3), CASP10(8), CASP3(2), CASP8(18), CASP9(3), GZMB(2), JUN(5), PRF1(13)	7569058	89	61	82	10	19	11	8	17	31	3	0.00490	0.941	1.000
56	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(10), CRK(1), GNAI1(3), GNAQ(3), GNB1(2), GNGT1(3), HRAS(1), MAP2K1(7), MAPK1(3), MAPK3(3), NFKB1(8), PIK3C2G(14), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), PTK2(11), PTK2B(16), PXN(6), RAF1(9), RELA(7)	16166225	229	129	176	31	61	43	44	32	48	1	1.40e-09	0.966	1.000
57	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(11), HLA-DRA(7), HLA-DRB1(1)	1393636	20	20	15	8	5	2	2	3	8	0	0.914	0.972	1.000
58	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2)	668133	2	2	2	1	0	0	2	0	0	0	0.759	0.972	1.000
59	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(4), LPL(9), NR3C1(9), PPARG(4), RETN(1), RXRA(13), TNF(3)	3397366	43	39	41	10	11	4	6	12	10	0	0.214	0.978	1.000
60	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(23), CD3E(2), GZMB(2), HLA-A(22), ICAM1(4), ITGAL(22), ITGB2(12), PRF1(13)	5115651	100	63	85	21	21	9	10	14	40	6	0.105	0.978	1.000
61	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(53), AXIN1(15), CCND1(2), CD14(1), CTNNB1(27), DVL1(8), FZD1(11), GJA1(13), GNAI1(3), GSK3B(6), IRAK1(7), LBP(3), LEF1(5), LY96(5), MYD88(4), NFKB1(8), PDPK1(1), PIK3CA(80), PIK3R1(12), PPP2CA(4), RELA(7), TIRAP(1), TLR4(27), TOLLIP(6), WNT1(10)	18003085	322	166	255	60	56	53	59	69	79	6	2.90e-06	0.980	1.000
62	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(33), ABCB11(11), ABCB4(29), ABCC1(14), ABCC3(14), GSTP1(1)	8412303	102	73	96	16	26	11	12	18	35	0	0.00259	0.984	1.000
63	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(3), CCR3(12), HLA-DRA(7), HLA-DRB1(1), IL3(1)	1784846	25	20	24	6	9	4	3	6	3	0	0.186	0.984	1.000
64	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(6), SLPI(2)	1005759	8	7	8	3	4	1	0	1	2	0	0.652	0.986	1.000
65	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), IFNG(2), IL2RA(2), IL4(4), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), TGFBR3(9), TOB1(1), TOB2(6)	6207476	73	61	69	16	16	5	16	12	24	0	0.155	0.986	1.000
66	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(8), SUCLA2(3)	1240358	11	11	11	3	6	0	1	1	3	0	0.534	0.991	1.000
67	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(6), ACAT2(5), OXCT1(10)	1985949	21	20	20	7	3	6	2	3	7	0	0.780	0.993	1.000
68	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(5), FOS(1), FYN(9), JUN(5), MAPK14(2), THBS1(17)	4344725	41	34	39	8	10	5	9	9	8	0	0.0845	0.994	1.000
69	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), INSR(17), IRS1(27), JUN(5), MAP2K1(7), MAPK3(3), MAPK8(6), PIK3CA(80), PIK3R1(12), PTPN11(8), RAF1(9), RASA1(19), SHC1(7), SLC2A4(5), SOS1(9), SRF(5)	14938999	234	122	178	37	49	49	42	37	53	4	1.94e-07	0.996	1.000
70	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3), IFNG(2), IL12A(3), IL12B(2), IL18(1)	1747883	11	10	11	4	2	3	1	4	1	0	0.734	0.996	1.000
71	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), CREB1(4), GRB2(4), HRAS(1), MAPK1(3), MAPK3(3), MAPK7(8), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), NTRK1(9), PIK3CA(80), PIK3R1(12), PLCG1(22), RPS6KA1(9), SHC1(7)	11095191	186	106	138	30	46	44	42	25	28	1	3.69e-07	0.997	1.000
72	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(4), CREBBP(46), EP300(27), FYN(9), IL2RG(9), IL7(2), IL7R(15), JAK1(19), JAK3(12), LCK(4), NMI(2), PIK3CA(80), PIK3R1(12), PTK2B(16), STAT5A(10), STAT5B(13)	16376636	280	126	218	44	63	51	52	47	64	3	1.88e-07	0.997	1.000
73	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(7), CBS(9), CTH(3), MUT(7)	2864191	29	27	28	6	6	3	3	2	15	0	0.316	0.998	1.000
74	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(6), PAPSS1(6), PAPSS2(6), SULT1A2(8), SULT1E1(3), SULT2A1(4), SUOX(7)	3588654	40	32	40	7	12	9	4	8	7	0	0.0587	0.998	1.000
75	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(12), CD4(11), HLA-DRA(7), HLA-DRB1(1), IL1B(4), IL4(4), IL5RA(8)	3135061	48	38	42	12	11	4	7	10	16	0	0.307	0.998	1.000
76	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(12), CFL1(1), GNAQ(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), LIMK1(6), MAP2K1(7), MAPK1(3), MAPK3(3), MYL2(9), NOX1(7), PIK3C2G(14), PLCB1(21), PPP1R12B(16), PRKCA(8), PTK2(11), RAF1(9), ROCK2(16)	14764064	191	103	180	28	66	21	18	40	46	0	5.37e-05	0.998	1.000
77	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(4), CD28(1), CD3E(2), CD4(11)	1887793	18	18	13	8	2	1	4	3	8	0	0.966	0.998	1.000
78	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(4), HLCS(6), SPCS1(2), SPCS3(3)	1799998	15	13	15	5	4	1	0	9	1	0	0.617	0.999	1.000
79	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(11), CD80(5), HLA-DRA(7), HLA-DRB1(1), IL10(2), IL4(4)	2331569	31	30	25	9	11	2	2	6	10	0	0.614	0.999	1.000
80	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(4), GBA(12), GGT1(9), SHMT1(2), SHMT2(11)	3200743	38	31	36	9	12	3	6	5	12	0	0.177	0.999	1.000
81	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(10), CCNE1(5), CDC34(2), CDK2(4), CUL1(24), E2F1(4), RB1(14), SKP2(6), TFDP1(5)	5022983	74	57	74	17	12	11	16	14	21	0	0.0497	0.999	1.000
82	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(7), ACADS(4), ACAT1(6), ECHS1(2), HADHA(5)	3169892	27	22	25	5	6	5	4	4	8	0	0.129	0.999	1.000
83	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), MIOX(6), UGDH(8)	4975235	71	47	62	15	15	8	11	12	25	0	0.109	0.999	1.000
84	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(5), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAP2K1(7), MAPK3(3), MPL(5), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), STAT1(11), STAT3(7), STAT5A(10), STAT5B(13), THPO(6)	17605329	256	128	203	36	60	49	46	47	51	3	1.30e-08	0.999	1.000
85	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(5), BIRC3(10), CASP8(18), FADD(3), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4)	4894710	57	46	53	13	9	8	6	8	25	1	0.333	1.000	1.000
86	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(4), FOS(1), JUN(5), KEAP1(11), MAFF(1), MAPK1(3), MAPK14(2), MAPK8(6), NFE2L2(2), PRKCA(8)	5186728	43	35	42	9	11	11	5	6	10	0	0.0369	1.000	1.000
87	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCL2(4), BCR(14), CRKL(2), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), MYC(6), PIK3CA(80), PIK3R1(12), RAF1(9), SOS1(9), STAT1(11), STAT5A(10), STAT5B(13)	16477058	237	126	183	40	50	48	43	39	54	3	4.55e-07	1.000	1.000
88	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(8), AASDHPPT(1), AASS(10), KARS(7)	2770822	26	20	26	6	6	5	5	6	4	0	0.258	1.000	1.000
89	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25A(5), CDC25B(6), CDC25C(11), CSK(8), GRB2(4), PRKCA(8), PTPRA(15), SRC(5)	5410644	65	46	62	12	20	5	9	11	19	1	0.0426	1.000	1.000
90	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(9), SHMT1(2), SHMT2(11)	2413569	23	20	21	8	7	3	2	1	10	0	0.502	1.000	1.000
91	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(6), ACAT2(5), ACYP1(1), ACYP2(3), ECHS1(2), EHHADH(4), GCDH(7), HADHA(5), SDHB(4), SDS(4)	4575240	41	30	37	8	7	8	8	3	15	0	0.111	1.000	1.000
92	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(11), CD8A(4), CSF1(5), CSF3(1), EPO(3), IL11(3), IL3(1), IL4(4), IL7(2)	3565277	34	30	28	9	9	4	4	6	11	0	0.487	1.000	1.000
93	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), NFYC(3), RB1(14), SP1(5), SP3(5)	3917350	28	24	28	5	6	4	6	4	8	0	0.110	1.000	1.000
94	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8)	3311151	25	20	24	5	4	0	6	9	6	0	0.200	1.000	1.000
95	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(3), GORASP1(4), MAP2K4(9), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MAPKAPK5(4), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PIK3CA(80), PIK3CD(15), PIK3R1(12), SYT1(5), TRAF2(4), TRAF3(7), TRAF5(4), TRAF6(6)	19660821	276	141	226	44	86	50	45	39	50	6	2.65e-09	1.000	1.000
96	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(28), CPT1A(14), LEP(3), LEPR(14), PRKAA1(7), PRKAA2(10), PRKAB1(11), PRKAB2(4), PRKAG1(5), PRKAG2(7)	8497428	103	64	99	18	30	10	10	24	28	1	0.0266	1.000	1.000
97	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(10), F13A1(19), F2(11), F2R(6), FGA(12), FGB(6), FGG(5), PLAT(7), PLG(18), SERPINB2(9), SERPINE1(3)	7868198	106	73	102	24	33	10	14	29	20	0	0.0415	1.000	1.000
98	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAA2(9), ACAT1(6), ACAT2(5), ECHS1(2), EHHADH(4), HADHA(5), HADHB(6), SDS(4)	4902371	44	30	42	9	6	9	11	3	15	0	0.0712	1.000	1.000
99	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(11), GLS2(8), GLUD1(4), GLUD2(13)	2669437	36	27	35	9	8	3	5	12	8	0	0.312	1.000	1.000
100	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAD(4), BAK1(4), BAX(1), BCL10(2), BCL2(4), BCL2L1(1), BCL2L11(4), BID(2), CASP9(3), CES1(16)	6389112	49	34	49	8	18	11	3	11	6	0	0.0242	1.000	1.000
101	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(5), DAB1(13), FYN(9), LRP8(5), RELN(52), VLDLR(7)	8227346	94	62	93	19	23	18	15	23	15	0	0.00432	1.000	1.000
102	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(8), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), DFFA(4), DFFB(3), DIABLO(1)	7882657	73	50	68	10	13	12	10	16	22	0	0.0159	1.000	1.000
103	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(4), DFFA(4), DFFB(3), GZMB(2), HMGB1(3), HMGB2(3), TOP2A(15), TOP2B(11)	5217700	47	35	38	8	6	6	5	14	16	0	0.333	1.000	1.000
104	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JAK1(19), JUN(5), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), PDGFA(2), PDGFRA(13), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5), STAT1(11), STAT3(7), STAT5A(10)	20498960	294	137	235	48	65	55	49	48	72	5	9.70e-08	1.000	1.000
105	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(8), CYP2C9(1)	1190402	9	7	9	5	5	1	0	2	1	0	0.935	1.000	1.000
106	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(6), CHRNA1(7), SNAP25(2), STX1A(4), VAMP2(1)	1912567	20	19	20	6	7	1	2	5	5	0	0.569	1.000	1.000
107	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCND1(2), CCNE1(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), E2F1(4), HRAS(1), MAPK1(3), MAPK3(3), NFKB1(8), NFKBIA(1), PAK1(5), PIK3CA(80), PIK3R1(12), RAC1(1), RAF1(9), RB1(14), RELA(7), TFDP1(5)	11871229	179	107	132	30	32	43	44	26	33	1	5.78e-06	1.000	1.000
108	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(6), COASY(4), DPYD(20), DPYS(8), ENPP1(7), ENPP3(12), PANK1(11), PANK2(6), PANK3(2), PANK4(5), PPCS(2), UPB1(6)	8177249	89	57	85	15	17	9	16	23	24	0	0.00379	1.000	1.000
109	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CCNH(3), CDC25A(5), CDC25B(6), CDC25C(11), MNAT1(3), SHH(6), XPO1(13)	5072964	50	36	46	11	12	10	4	11	12	1	0.165	1.000	1.000
110	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(6), COQ5(1), COQ6(4), COQ7(4), NDUFA12(2), NDUFA13(2), NDUFB11(2)	2338753	21	19	21	8	6	2	3	3	7	0	0.754	1.000	1.000
111	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(49), CDC25A(5), CDC25B(6), CDC25C(11), CHEK1(6), MYT1(22), WEE1(6), YWHAH(3)	8091041	108	68	101	22	25	14	10	24	31	4	0.0944	1.000	1.000
112	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(5), IL1B(4), MST1R(13), TNF(3)	3835744	26	22	25	4	3	4	0	7	12	0	0.153	1.000	1.000
113	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(38), GNB1(2), GNGT1(3), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8)	5665591	93	65	86	20	43	8	4	16	22	0	0.0843	1.000	1.000
114	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2)	8821947	119	73	104	23	26	16	16	21	39	1	0.0354	1.000	1.000
115	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2)	8821947	119	73	104	23	26	16	16	21	39	1	0.0354	1.000	1.000
116	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2)	8821947	119	73	104	23	26	16	16	21	39	1	0.0354	1.000	1.000
117	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(49), CCNA1(10), CCNB1(3), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(5), CDK2(4), CDK4(2), CDKN1A(5), CDKN1B(1), CDKN2A(17), CDKN2B(1), CDKN2C(1), CDKN2D(4), CREB3L1(5), CREB3L3(6), CREB3L4(3), E2F1(4), E2F2(5), E2F3(3), E2F4(2), E2F5(4), GBA2(6), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), MNAT1(3), MYC(6), MYT1(22), NACA(19), PCNA(2), POLA2(4), POLE(34), POLE2(5), PRIM1(2), RB1(14), RBL1(12), RPA1(3), RPA2(4), RPA3(1), TFDP1(5), TFDP2(4), TNXB(68), TP53(200), WEE1(6)	45279709	641	280	534	124	190	81	71	109	183	7	2.12e-09	1.000	1.000
118	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(26), DIAPH1(14), FYN(9), GSN(12), HRAS(1), ITGA1(7), ITGB1(11), MAP2K1(7), MAPK1(3), MAPK3(3), MYL2(9), MYLK(25), PFN1(1), PIK3CA(80), PIK3R1(12), PTK2(11), PXN(6), RAF1(9), ROCK1(20), SHC1(7), SRC(5), TLN1(28)	21913223	306	139	247	48	80	55	53	54	57	7	1.17e-08	1.000	1.000
119	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(4), FOS(1), HRAS(1), JUN(5), MAP2K1(7), MAPK1(3), MAPK3(3), MYC(6), NFKB1(8), NFKBIA(1), PLCB1(21), PRKCA(8), RAF1(9), RELA(7), TNF(3)	9116715	87	62	81	16	23	12	8	22	22	0	0.0106	1.000	1.000
120	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(33), GNA12(1), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAR2A(3), PRKAR2B(9)	5922815	66	51	62	14	13	8	10	11	22	2	0.170	1.000	1.000
121	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6)	4671816	67	43	58	20	15	6	8	12	26	0	0.558	1.000	1.000
122	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6)	4671816	67	43	58	20	15	6	8	12	26	0	0.558	1.000	1.000
123	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8)	7370870	83	54	78	20	23	12	13	19	16	0	0.0802	1.000	1.000
124	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(3), EIF4A2(6), EIF4B(5), EIF4E(2), EIF4EBP1(4), EIF4G1(25), EIF4G3(22), FKBP1A(2), MKNK1(5), PDK2(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PPP2CA(4), PTEN(36), RPS6(1), RPS6KB1(6), TSC1(10), TSC2(14)	16184727	242	122	182	39	50	42	51	39	55	5	7.13e-06	1.000	1.000
125	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(19), AP2A1(14), AP2M1(8), BIN1(7), CALM1(2), CALM2(3), CALM3(1), DNM1(6), EPN1(8), EPS15(2), NME2(3), PICALM(4), PPP3CA(13), PPP3CB(6), PPP3CC(6), SYNJ1(11), SYNJ2(20), SYT1(5)	12712095	138	76	129	20	40	16	15	28	39	0	2.66e-05	1.000	1.000
126	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(1), RANBP2(36), RANGAP1(14)	4949325	53	41	52	15	8	9	12	11	11	2	0.251	1.000	1.000
127	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(21), ARHGEF1(12), F2(11), F2R(6), F2RL3(4), GNA12(1), GNA13(7), GNAI1(3), GNAQ(3), GNB1(2), GNGT1(3), MAP3K7(11), PIK3CA(80), PIK3R1(12), PLCB1(21), PPP1R12B(16), PRKCA(8), PTK2B(16), ROCK1(20)	15161315	257	134	207	46	65	48	51	43	46	4	8.97e-07	1.000	1.000
128	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(9), ECHS1(2), HADH(2), HADHA(5), HADHB(6), HSD17B4(7), MECR(4), PPT1(5), PPT2(3)	4964482	43	27	42	8	8	8	12	3	12	0	0.0162	1.000	1.000
129	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(3), BAK1(4), BAX(1), BFAR(5), BTK(4), CAD(20), CASP10(8), CASP3(2), CASP8(18), CD7(5), CDK2AP1(1), CSNK1A1(5), DAXX(11), DEDD(3), DEDD2(3), DFFA(4), DIABLO(1), EGFR(19), EPHB2(15), FADD(3), FAF1(10), FAIM2(1), HSPB1(2), IL1A(2), MAP2K4(9), MAP2K7(38), MAP3K1(16), MAP3K5(10), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MET(10), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR0B2(3), PFN1(1), PFN2(1), PTPN13(34), RALBP1(10), RIPK1(3), ROCK1(20), SMPD1(6), TP53(200), TPX2(7), TRAF2(4)	42616830	609	268	502	119	177	71	71	96	185	9	2.56e-08	1.000	1.000
130	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), FDXR(10), SHMT1(2)	9380013	129	75	114	25	30	18	19	21	40	1	0.0205	1.000	1.000
131	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(16), GBA(12), LPO(11), MPO(9), PRDX6(2), TPO(27)	4887943	77	63	74	19	29	9	8	20	10	1	0.118	1.000	1.000
132	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(11), CD44(8), CSF1(5), FCGR3A(5), IL1B(4), IL6R(3), SELL(6), SPN(4), TGFB1(3), TGFB2(9), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(7), TNFSF8(4)	7689174	81	57	78	22	22	7	8	19	24	1	0.183	1.000	1.000
133	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(7), HLA-DRA(7), HLA-DRB1(1), IFNG(2), IFNGR1(10), IFNGR2(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18(1), IL18R1(6), IL2RA(2), IL4(4), IL4R(7)	7425987	74	51	74	19	18	10	12	15	19	0	0.127	1.000	1.000
134	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), CREB1(4), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), NFKB1(8), PIK3CA(80), PIK3R1(12), RB1(14), RELA(7), SP1(5)	11376961	179	111	128	32	32	38	45	26	37	1	3.37e-05	1.000	1.000
135	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(6), BCAT2(9), COASY(4), DPYD(20), DPYS(8), ENPP1(7), ENPP3(12), ILVBL(8), PANK1(11), PANK2(6), PANK3(2), PANK4(5), PPCDC(1), PPCS(2), UPB1(6), VNN1(4)	10155213	111	67	107	20	28	10	18	29	26	0	0.00241	1.000	1.000
136	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(9), ACP2(5), ACP5(3), ACPP(5), ACPT(6), ENPP1(7), ENPP3(12), FLAD1(5), RFK(2), TYR(15)	5693618	69	50	61	14	11	10	14	15	19	0	0.0859	1.000	1.000
137	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(53), AXIN1(15), CREBBP(46), CTNNB1(27), DVL1(8), EP300(27), FZD1(11), GSK3B(6), HDAC1(9), LDB1(4), LEF1(5), PITX2(5), TRRAP(62), WNT1(10)	19433883	288	139	262	58	89	25	34	52	83	5	0.000194	1.000	1.000
138	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(5)	1539314	10	10	10	9	4	2	1	2	1	0	0.972	1.000	1.000
139	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(8), CYSLTR2(1), GPR161(12), GPR171(2), GPR18(3), GPR39(10), GPR45(17), GPR65(1), GPR68(4), GPR75(5)	5775854	63	48	56	17	26	4	8	9	16	0	0.204	1.000	1.000
140	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(28), ACACB(40), FASN(27), MCAT(3), OLAH(1), OXSM(6)	9197344	105	64	100	22	31	14	15	24	20	1	0.0107	1.000	1.000
141	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(14), APOBEC1(6), APOBEC2(3), APOBEC3B(5), APOBEC3C(1), APOBEC3F(2), APOBEC3G(3), APOBEC4(2)	4299379	36	25	36	7	11	7	5	6	7	0	0.119	1.000	1.000
142	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(5), ANKRD1(5), ATF3(2), CYR61(2), DUSP14(3), EIF4E(2), EIF4EBP1(4), HBEGF(2), IFNG(2), IFRD1(10), IL18(1), IL1A(2), IL1R1(4), JUND(2), MYOG(4), NR4A3(6), WDR1(4)	6261577	60	42	56	14	21	6	5	10	18	0	0.135	1.000	1.000
143	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(8), NFKBIA(1), PLCB1(21), PRKCA(8), RELA(7)	4828342	48	37	46	11	13	6	4	12	13	0	0.148	1.000	1.000
144	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(2), EHHADH(4), HADHA(5), SDS(4)	2837256	18	15	17	6	4	3	3	2	6	0	0.453	1.000	1.000
145	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6)	7746845	86	54	76	19	18	7	14	19	28	0	0.0904	1.000	1.000
146	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), BAD(4), CHRNB1(4), CHRNG(8), MUSK(16), PIK3CA(80), PIK3R1(12), PTK2(11), PTK2B(16), RAPSN(3), SRC(5), TERT(9), YWHAH(3)	9576201	174	102	127	35	44	38	41	27	23	1	4.97e-05	1.000	1.000
147	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(8), BIRC2(7), BIRC3(10), CASP10(8), CASP3(2), CASP7(4), CASP8(18), CASP9(3), DFFA(4), DFFB(3), GZMB(2), PRF1(13), SCAP(14), SREBF1(15), SREBF2(15)	10628071	126	77	119	22	34	13	16	27	36	0	0.0119	1.000	1.000
148	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(4), CREBBP(46), DFFA(4), DFFB(3), GZMA(4), GZMB(2), HMGB2(3), PRF1(13), SET(7)	6199182	87	60	83	22	27	10	13	18	19	0	0.101	1.000	1.000
149	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(7), F13B(17), HSD17B1(4), HSD17B2(3), HSD17B3(2), HSD17B4(7), HSD17B7(5), HSD3B1(4), HSD3B2(2)	4751597	51	40	51	14	7	10	10	15	9	0	0.206	1.000	1.000
150	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(46), EP300(27), ESR1(8), MAPK1(3), MAPK3(3), PELP1(8), SRC(5)	8597548	100	68	95	24	36	10	15	16	23	0	0.0488	1.000	1.000
151	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(3), CALM3(1), CCL2(1), CCR5(4), FOS(1), GNAQ(3), JUN(5), MAPK14(2), MAPK8(6), PLCG1(22), PRKCA(8), PTK2B(16), SYT1(5)	8104830	79	59	75	17	31	11	9	10	18	0	0.0133	1.000	1.000
152	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), ESRRA(2), HDAC5(13), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), PPARA(7), PPP3CA(13), PPP3CB(6), PPP3CC(6), SLC2A4(5), SYT1(5), YWHAH(3)	11828647	130	84	126	28	33	17	17	28	35	0	0.00542	1.000	1.000
153	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(5), CPS1(24), GLS(11), GLUD1(4), GOT1(3)	4578154	49	39	48	12	15	4	6	16	8	0	0.202	1.000	1.000
154	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(21), CREM(6), FHL5(5), FSHB(1), FSHR(24), GNAS(38), XPO1(13)	5652287	108	73	100	26	42	15	10	30	10	1	0.146	1.000	1.000
155	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF4E(2), EIF4EBP1(4), GSK3B(6), IGF1(2), IGF1R(20), INPPL1(27), PDK2(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PPP2CA(4), PTEN(36), RPS6(1), RPS6KB1(6)	11527374	220	113	155	42	44	38	45	34	54	5	0.000618	1.000	1.000
156	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(4), BAX(1), BCL2(4), CASP8(18), FADD(3), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), NFKB1(8), NSMAF(10), RAF1(9), RELA(7), RIPK1(3), SMPD1(6), TNFRSF1A(6), TRADD(2), TRAF2(4)	12013615	129	78	118	29	37	18	10	16	45	3	0.0368	1.000	1.000
157	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(6), GNAQ(3), GNB1(2), GNGT1(3), HTR2C(10), PLCB1(21), TUB(7)	4198897	52	39	50	13	14	5	6	14	13	0	0.270	1.000	1.000
158	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IGF1(2), IGF1R(20), IRS1(27), JUN(5), MAP2K1(7), MAPK3(3), MAPK8(6), PIK3CA(80), PIK3R1(12), PTPN11(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5)	14548500	234	119	178	46	50	46	43	41	51	3	5.46e-05	1.000	1.000
159	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(8), CHPT1(4), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(5), PCYT1A(9), PCYT1B(6), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), WBSCR22(5)	8225990	90	56	85	17	20	14	13	18	24	1	0.0136	1.000	1.000
160	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(3), DAG1(13), GNAQ(3), ITPKA(2), ITPKB(14)	3549388	39	29	38	12	15	1	7	8	8	0	0.416	1.000	1.000
161	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), PRKCE(14)	4620560	84	57	82	29	20	6	17	31	10	0	0.516	1.000	1.000
162	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(3), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(6), NDUFV1(6), NDUFV2(1)	4057689	36	28	35	8	6	7	6	8	9	0	0.274	1.000	1.000
163	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(4), LDLR(12), NR0B2(3), NR1H3(5), NR1H4(6), RXRA(13)	3196091	43	32	42	14	21	3	3	6	10	0	0.316	1.000	1.000
164	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(2), GLS(11), GLUD1(4), OAT(3), PRODH(1)	3232073	25	19	24	8	6	4	2	7	6	0	0.463	1.000	1.000
165	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(22), PRKCA(8), PTK2B(16)	3956875	51	40	47	12	26	6	3	4	12	0	0.0644	1.000	1.000
166	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(5), EGF(11), EGFR(19), ELK1(4), FOS(1), GRB2(4), HRAS(1), JAK1(19), JUN(5), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5), STAT1(11), STAT3(7), STAT5A(10)	22007050	309	142	249	56	73	57	48	51	75	5	1.20e-06	1.000	1.000
167	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(53), AXIN1(15), BTRC(9), CCND1(2), CREBBP(46), CSNK1A1(5), CSNK1D(4), CSNK2A1(5), CTBP1(5), CTNNB1(27), DVL1(8), FZD1(11), GSK3B(6), HDAC1(9), MAP3K7(11), MYC(6), NLK(15), PPARD(8), PPP2CA(4), TLE1(13), WIF1(3), WNT1(10)	17175559	275	133	240	60	72	30	26	43	99	5	0.00849	1.000	1.000
168	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(7), GOSR1(2), GOSR2(3), SNAP25(2), SNAP29(2), STX10(4), STX11(7), STX12(3), STX16(10), STX17(2), STX18(2), STX19(4), STX2(6), STX3(2), STX4(4), STX5(1), STX6(6), STX7(4), STX8(4), TSNARE1(8), USE1(5), VAMP1(1), VAMP2(1), VAMP4(1), VAMP5(1), VAMP7(2), VTI1A(3), VTI1B(3), YKT6(4)	9778185	105	64	102	19	33	18	14	15	25	0	0.00468	1.000	1.000
169	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(9), ACP2(5), ACP5(3), ACP6(3), ACPP(5), ACPT(6), ENPP1(7), ENPP3(12), FLAD1(5), LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), PHPT1(2), RFK(2), TYR(15)	8825734	102	68	93	23	19	14	19	20	30	0	0.0625	1.000	1.000
170	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGB1(11), ITGB2(12), SELE(6), SELL(6)	7097884	85	54	80	26	26	5	12	20	22	0	0.179	1.000	1.000
171	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(5), MAPK14(2), MAPK8(6), NFKB1(8), RELA(7), TNFRSF13B(7), TNFRSF13C(4), TNFRSF17(1), TNFSF13(6), TNFSF13B(4), TRAF2(4), TRAF3(7), TRAF5(4), TRAF6(6)	8508821	71	53	70	14	14	16	5	15	20	1	0.0686	1.000	1.000
172	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT5(4), FUT8(9), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7)	4623405	53	47	52	14	22	9	5	8	9	0	0.246	1.000	1.000
173	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(6), AOC2(10), AOC3(13), CES1(16), DDHD1(13), ESCO1(10), ESCO2(10), LIPA(3), NAT6(4), PLA1A(3), PNPLA3(4), PPME1(1), PRDX6(2), SH3GLB1(3)	14847075	98	64	92	12	22	9	8	20	39	0	0.0125	1.000	1.000
174	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(11), BMPR1A(12), BMPR1B(9), BMPR2(21)	3675816	53	42	51	13	8	3	9	7	24	2	0.438	1.000	1.000
175	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(6), CDO1(3), CSAD(7), GAD1(8), GAD2(15), GGT1(9)	3362127	48	38	46	17	16	6	5	8	13	0	0.433	1.000	1.000
176	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), NAT1(2), NAT2(6), XDH(23)	4685062	64	54	63	19	16	12	10	18	8	0	0.274	1.000	1.000
177	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(11), EGFR(19), ERBB3(43), NRG1(16)	6049811	89	63	79	25	31	16	11	23	8	0	0.112	1.000	1.000
178	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(8), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(3), ST8SIA1(12)	3309705	47	41	45	16	21	2	7	10	7	0	0.465	1.000	1.000
179	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(4), CREM(6), FOS(1), JUN(5), MAPK3(3), OPRK1(17), POLR2A(24), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	7550521	99	68	94	26	24	17	15	17	26	0	0.0900	1.000	1.000
180	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(4), CAT(6), EPX(16), LPO(11), MPO(9), MTHFR(10), PRDX6(2), SHMT1(2), SHMT2(11), TPO(27)	6785949	98	73	94	25	34	11	7	22	23	1	0.119	1.000	1.000
181	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(4), IFNG(2), IFNGR1(10), JAK1(19), JAK2(12), PLA2G2A(2), PTPRU(26), REG1A(4), STAT1(11)	6722624	90	62	86	25	25	16	9	11	26	3	0.255	1.000	1.000
182	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(8), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), WBSCR22(5)	8792934	90	55	84	19	21	12	13	17	26	1	0.0326	1.000	1.000
183	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(8), ASPH(9), COPS5(3), CREB1(4), EDN1(4), EP300(27), EPO(3), HIF1A(5), JUN(5), LDHA(7), NOS3(15), P4HB(3), VHL(2)	9947001	95	61	88	21	23	13	15	17	27	0	0.0674	1.000	1.000
184	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(8), IFNB1(3), JAK1(19), PTPRU(26), REG1A(4), STAT1(11), STAT2(6), TYK2(12)	7312970	89	60	85	24	30	10	8	10	29	2	0.277	1.000	1.000
185	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(7), PRKCA(8), TGM2(12)	2905955	32	27	31	11	17	4	0	6	5	0	0.340	1.000	1.000
186	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(7), ACO2(11), FH(4), IDH1(4), IDH2(4), MDH1(3), SDHB(4), SUCLA2(3)	5225598	40	29	39	11	13	7	4	5	11	0	0.379	1.000	1.000
187	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(4), CD3E(2), CD4(11), CD58(7), CD8A(4), CSF3(1), IL3(1), KITLG(4)	3626395	38	32	32	13	4	4	7	7	16	0	0.750	1.000	1.000
188	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(4), GRB2(4), HRAS(1), PTK2B(16), SHC1(7), SOS1(9), SRC(5)	5184522	46	37	45	12	15	6	4	12	9	0	0.255	1.000	1.000
189	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(6), NR1I3(3), PTGS1(13), PTGS2(7)	3139721	34	26	34	10	13	4	4	6	6	1	0.357	1.000	1.000
190	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(12), MBTPS1(12), MBTPS2(7), SCAP(14), SREBF1(15), SREBF2(15)	6929133	77	50	75	19	25	6	10	13	23	0	0.124	1.000	1.000
191	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(11), ACO1(7), ACO2(11), ACSS1(16), ACSS2(12), FH(4), IDH1(4), IDH2(4), MDH1(3), SUCLA2(3)	7805636	75	49	73	18	20	15	7	12	21	0	0.129	1.000	1.000
192	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(10), AKT3(8), CISH(4), GRB2(4), IARS(11), IL13RA1(5), IL2RG(9), IL4(4), IL4R(7), INPP5D(8), JAK1(19), JAK2(12), JAK3(12), NR0B2(3), PI3(2), PIK3CA(80), PPP1R13B(15), RPS6KB1(6), SERPINA4(5), SHC1(7), SOS1(9), SOS2(18), SRC(5), STAT6(7), TYK2(12)	21613417	285	135	224	53	60	56	49	48	69	3	5.68e-05	1.000	1.000
193	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ESCO1(10), ESCO2(10), NAT6(4), PNPLA3(4), SH3GLB1(3)	9727397	50	39	48	7	12	4	5	8	21	0	0.0701	1.000	1.000
194	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(7), GAD1(8), HDC(11), PNMT(11), TH(7), TPH1(4)	3530034	48	41	47	17	16	7	4	7	14	0	0.563	1.000	1.000
195	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(14), AMT(4), ATIC(5), ATP6V0C(1), GART(10), MTHFD1(7), MTHFD1L(8), MTHFD2(1), MTHFR(10), MTHFS(3), MTR(19), SHMT1(2), SHMT2(11), TYMS(1)	10488007	96	62	92	23	25	14	14	17	25	1	0.0210	1.000	1.000
196	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(14), PDXK(4), PDXP(2), PNPO(2), PSAT1(7)	2838566	29	23	29	11	4	5	4	8	6	2	0.626	1.000	1.000
197	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(1), FOSL2(10), IFNAR1(8), IFNAR2(4), IFNB1(3), MAPK8(6), NFKB1(8), RELA(7), TNFRSF11A(4), TNFSF11(5), TRAF6(6)	6488091	63	50	63	19	15	11	7	15	15	0	0.339	1.000	1.000
198	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(7), FDFT1(3), FDPS(12), HMGCR(7), IDI1(2), LSS(14), MVD(2), MVK(15), NQO1(3), NQO2(3), PMVK(1), SQLE(9), VKORC1(1)	6438087	79	43	68	19	20	9	6	18	26	0	0.210	1.000	1.000
199	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(5), GSS(2), NFKB1(8), NOX1(7), RELA(7), TNF(3), XDH(23)	5813886	55	40	55	15	12	12	6	14	11	0	0.239	1.000	1.000
200	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF3(1), EPO(3), FLT3(12), IGF1(2), IL11(3), IL1A(2), IL3(1), KITLG(4), TGFB1(3), TGFB2(9), TGFB3(9)	4856420	50	39	47	17	15	7	5	12	11	0	0.533	1.000	1.000
201	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(8), IFNAR2(4), IFNB1(3), JAK1(19), STAT1(11), STAT2(6), TYK2(12)	6345965	64	44	61	18	16	7	9	9	21	2	0.472	1.000	1.000
202	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), SDS(4)	7113853	82	46	72	26	18	9	10	14	31	0	0.532	1.000	1.000
203	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(2), CALM2(3), CALM3(1), CD3E(2), ELK1(4), FOS(1), FYN(9), GRB2(4), HRAS(1), JUN(5), LAT(3), LCK(4), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKBIA(1), PIK3CA(80), PIK3R1(12), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), PTPN7(7), RAC1(1), RAF1(9), RASA1(19), RELA(7), SHC1(7), SOS1(9), SYT1(5), VAV1(13), ZAP70(13)	28059091	389	154	327	73	114	64	55	63	90	3	2.72e-08	1.000	1.000
204	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(23), CALR(2), CANX(3), CD4(11), CD74(4), CD8A(4), CD8B(2), CIITA(20), CREB1(4), CTSB(3), CTSS(5), HLA-A(22), HLA-B(29), HLA-C(7), HLA-DMA(1), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(4), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), HLA-E(6), HLA-F(8), HLA-G(5), HSP90AA1(13), HSP90AB1(10), HSPA5(4), IFI30(3), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), KIR2DL3(4), KIR3DL1(10), KIR3DL2(3), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), LGMN(7), LTA(4), NFYB(1), NFYC(3), PDIA3(5), PSME1(3), PSME2(2), RFX5(12), RFXANK(6), RFXAP(2), TAP1(5), TAP2(10), TAPBP(7)	27215112	348	133	320	62	55	39	62	76	105	11	7.74e-05	1.000	1.000
205	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(10), IFNGR2(2), JAK1(19), JAK2(12), STAT1(11)	4820354	56	41	53	18	9	11	7	8	18	3	0.681	1.000	1.000
206	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(13), PARK2(13), SNCA(1), SNCAIP(16), UBE2E2(1), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1)	3773034	51	42	49	19	15	8	8	12	8	0	0.468	1.000	1.000
207	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(53), ASAH1(4), CAMP(3), CASP3(2), CERK(7), CREB1(4), CREB5(7), CXCL2(2), DAG1(13), EPHB2(15), FOS(1), GNAQ(3), ITPKA(2), ITPKB(14), JUN(5), MAP2K4(9), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5)	16714024	224	117	215	53	71	23	26	33	64	7	0.00366	1.000	1.000
208	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(8), EIF1(1), EIF2B1(4), EIF2B2(4), EIF2B3(9), EIF2B4(11), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), ELAVL1(9), FLT1(19), FLT4(31), HIF1A(5), HRAS(1), KDR(17), NOS3(15), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), PTK2(11), PXN(6), SHC1(7), VHL(2)	19919320	297	135	240	55	77	50	60	53	56	1	8.06e-07	1.000	1.000
209	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(21), AKT1(3), ASAH1(4), GNAI1(3), GNB1(2), GNGT1(3), ITGAV(18), ITGB3(6), MAPK1(3), MAPK3(3), PDGFA(2), PDGFRA(13), PIK3CA(80), PIK3R1(12), PLCB1(21), PRKCA(8), PTK2(11), RAC1(1), SMPD1(6), SMPD2(3), SPHK1(10), SRC(5)	16104154	238	120	186	49	56	47	52	34	47	2	4.19e-05	1.000	1.000
210	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(4), BLVRB(1), HMOX1(7), IL10(2), IL10RA(5), IL10RB(2), IL1A(2), JAK1(19), STAT1(11), STAT3(7), STAT5A(10), TNF(3)	7151718	73	55	70	21	15	9	7	18	22	2	0.460	1.000	1.000
211	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(5), BRAF(18), CAMP(3), CREB1(4), CREB5(7), MAPK1(3), RAF1(9), SNX13(7), SRC(5), TERF2IP(5)	6555879	70	51	63	18	18	10	8	13	21	0	0.296	1.000	1.000
212	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(5), EGR1(12), HRAS(1), KLK2(1), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), NGFR(7), RAF1(9)	4788308	54	40	49	18	20	7	6	10	11	0	0.328	1.000	1.000
213	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(6), CHST11(4), CHST12(6), CHST13(5), PAPSS1(6), PAPSS2(6), SULT1A1(9), SULT1A2(8), SULT1E1(3), SULT2A1(4), SULT2B1(1), SUOX(7)	5409524	65	46	64	18	26	10	6	12	11	0	0.121	1.000	1.000
214	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(9), ALOX15(10), ALOX15B(4), ALOX5(11), ALOX5AP(2), DPEP1(3), GGT1(9), LTA4H(4), PLA2G2A(2), PLA2G6(8), PTGDS(1), PTGES(1), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7)	8782231	99	64	98	25	38	10	10	20	19	2	0.0321	1.000	1.000
215	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(33), CR2(25), FCGR2B(3), HLA-DRA(7), HLA-DRB1(1), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21)	8911059	133	81	115	34	33	18	17	26	39	0	0.0978	1.000	1.000
216	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(21), GNAS(38), GNB1(2), GNGT1(3), PRKACA(6), PRKAR1A(4)	3908004	74	51	70	21	36	5	3	15	14	1	0.408	1.000	1.000
217	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(3), IL12B(2), IL13(4), IL15(1), IL16(18), IL18(1), IL1A(2), IL3(1), IL4(4), LTA(4), TNF(3)	5828745	51	41	51	18	11	7	7	14	12	0	0.548	1.000	1.000
218	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMC2(5), PSMC3(9), PSMD1(10), PSMD11(4), PSMD12(5), PSMD13(2), PSMD2(17), PSMD6(5)	9386180	94	56	94	18	25	13	18	18	20	0	0.0226	1.000	1.000
219	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(14), ABCC2(17), ABCG2(5), BCHE(19), CES1(16), CES2(9), CYP3A4(3), CYP3A5(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3)	13418172	125	75	118	29	27	18	15	27	38	0	0.0753	1.000	1.000
220	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(11), CSF1(5), CSF3(1), HLA-DRA(7), HLA-DRB1(1), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL11(3), IL12A(3), IL12B(2), IL13(4), IL15(1), IL1A(2), IL3(1), IL4(4), IL7(2), LTA(4), PDGFA(2), TGFB1(3), TGFB2(9), TGFB3(9), TNF(3)	7800711	85	63	77	26	23	12	10	17	23	0	0.442	1.000	1.000
221	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(6), CYB5R3(4), GCK(9), GFPT1(7), GNE(11), GNPDA1(4), GNPDA2(7), HEXA(2), HEXB(3), HK1(17), HK2(12), HK3(11), PGM3(13), RENBP(3), UAP1(5)	9926324	114	72	110	28	38	19	17	26	14	0	0.0196	1.000	1.000
222	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(4), ATP6V0C(1), CAT(6), EPX(16), LPO(11), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), SHMT1(2), SHMT2(11), TPO(27)	6889067	92	71	88	27	29	11	8	21	22	1	0.255	1.000	1.000
223	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(9), HK1(17), HK2(12), HK3(11), IMPA1(7), PGM1(3), PGM3(13), TGDS(5)	5996018	77	56	74	25	24	14	13	20	6	0	0.207	1.000	1.000
224	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(10), AKT3(8), CDKN1A(5), ELK1(4), GRB2(4), HRAS(1), MAP2K1(7), MAP2K2(3), NGFR(7), NTRK1(9), PIK3CA(80), PIK3CD(15), SHC1(7), SOS1(9)	9455546	172	107	122	40	47	39	36	36	14	0	0.000901	1.000	1.000
225	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), BAD(4), GRB2(4), HRAS(1), IGF1R(20), IRS1(27), MAP2K1(7), MAPK1(3), MAPK3(3), PIK3CA(80), PIK3R1(12), RAF1(9), SHC1(7), SOS1(9), YWHAH(3)	11143161	192	111	140	41	44	42	42	29	33	2	0.000500	1.000	1.000
226	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(4), CRK(1), CRKL(2), DOCK1(20), ELK1(4), FOS(1), GAB1(4), GRB2(4), HGF(20), HRAS(1), ITGA1(7), ITGB1(11), JUN(5), MAP2K1(7), MAP2K2(3), MAP4K1(4), MAPK1(3), MAPK3(3), MAPK8(6), MET(10), PAK1(5), PIK3CA(80), PIK3R1(12), PTEN(36), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAF1(9), RAP1A(3), RAP1B(6), RASA1(19), SOS1(9), SRC(5), STAT3(7)	25867255	352	156	282	74	75	53	60	72	87	5	6.43e-05	1.000	1.000
227	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(5), BIRC2(7), BIRC3(10), CASP3(2), CASP8(18), CFLAR(1), FADD(3), JUN(5), MAP2K4(9), MAP3K3(9), MAP3K7(11), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR2C2(6), RALBP1(10), RIPK1(3), TNF(3), TNFAIP3(11), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4)	15957910	160	86	154	32	39	21	19	29	49	3	0.0175	1.000	1.000
228	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(8), CDKN1A(5), EPO(3), EPOR(3), GRIN1(11), HIF1A(5), JAK2(12), NFKB1(8), NFKBIA(1), RELA(7), SOD2(2)	7412793	65	43	64	17	14	16	7	8	19	1	0.158	1.000	1.000
229	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(9), HK1(17), HK2(12), HK3(11), IMPA1(7), IMPA2(2), ISYNA1(4), PGM1(3), PGM3(13), TGDS(5)	6826018	83	60	79	27	28	14	13	22	6	0	0.166	1.000	1.000
230	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CAMKK1(5), CAMKK2(2), CREB1(4), SYT1(5)	6759791	65	47	64	21	16	9	14	10	16	0	0.324	1.000	1.000
231	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(26), ARHGEF1(12), GNA12(1), GNA13(7), GNAQ(3), GNB1(2), GNGT1(3), MYL2(9), MYLK(25), PLCB1(21), PPP1R12B(16), PRKCA(8), ROCK1(20)	12130833	153	93	145	31	40	19	17	31	40	6	0.0157	1.000	1.000
232	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8)	10253111	101	60	95	28	32	13	13	21	22	0	0.203	1.000	1.000
233	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(15), ACVR1C(5), AKT1(3), AKT2(10), AKT3(8), ARRB1(3), ARRB2(2), ATF2(4), ATF4(2), BDNF(9), BRAF(18), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1F(14), CACNA1G(27), CACNA1H(40), CACNA1I(26), CACNA1S(26), CACNA2D1(19), CACNA2D2(7), CACNA2D3(22), CACNA2D4(12), CACNB1(4), CACNB2(19), CACNB3(4), CACNB4(7), CACNG1(5), CACNG2(3), CACNG3(6), CACNG4(2), CACNG5(9), CACNG6(3), CACNG7(11), CACNG8(4), CASP3(2), CD14(1), CDC25B(6), CDC42(3), CHUK(5), CRK(1), CRKL(2), DAXX(11), DDIT3(5), DUSP1(3), DUSP10(8), DUSP14(3), DUSP16(12), DUSP2(1), DUSP3(1), DUSP4(2), DUSP5(9), DUSP6(4), DUSP7(1), DUSP8(2), DUSP9(8), ECSIT(6), EGF(11), EGFR(19), ELK1(4), ELK4(1), FAS(3), FASLG(5), FGF1(3), FGF10(5), FGF11(1), FGF12(9), FGF13(15), FGF14(7), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(3), FGF3(1), FGF5(4), FGF6(7), FGF7(5), FGF8(1), FGF9(10), FGFR1(18), FGFR2(11), FGFR3(9), FGFR4(18), FLNA(28), FLNB(33), FLNC(38), FOS(1), GADD45B(1), GNA12(1), GNG12(12), GRB2(4), HRAS(1), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), JUN(5), JUND(2), KRAS(37), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP2K7(38), MAP3K1(16), MAP3K10(13), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K6(10), MAP3K7(11), MAP3K8(2), MAP4K1(4), MAP4K2(10), MAP4K3(5), MAP4K4(13), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK7(8), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MAPKAPK2(3), MAPKAPK3(5), MAPKAPK5(4), MAPT(11), MAX(3), MEF2C(5), MKNK1(5), MKNK2(8), MOS(11), MRAS(4), MYC(6), NF1(32), NFATC2(26), NFATC4(16), NFKB1(8), NFKB2(9), NLK(15), NR4A1(5), NRAS(4), NTF3(5), NTRK1(9), NTRK2(16), PAK1(5), PAK2(12), PDGFA(2), PDGFB(6), PDGFRA(13), PDGFRB(12), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PPM1A(5), PPM1B(14), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PPP5C(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PTPN5(9), PTPN7(7), PTPRR(10), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF2(16), RASA1(19), RASA2(10), RASGRF1(15), RASGRF2(15), RASGRP1(7), RASGRP2(8), RASGRP3(6), RASGRP4(6), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KA5(5), RPS6KA6(20), RRAS(1), RRAS2(3), SOS1(9), SOS2(18), SRF(5), STK3(5), STK4(3), STMN1(2), TAOK1(11), TAOK2(20), TAOK3(12), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), TNF(3), TNFRSF1A(6), TP53(200), TRAF2(4), TRAF6(6), ZAK(8)	167017703	2324	348	2093	590	760	300	281	398	565	20	5.88e-15	1.000	1.000
234	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), AKT1(3), AKT2(10), AKT3(8), ARHGAP5(26), BAD(4), BCAR1(10), BCL2(4), BIRC2(7), BIRC3(10), BRAF(18), CAPN2(10), CAV1(5), CAV2(1), CAV3(2), CCND1(2), CCND2(2), CCND3(1), CDC42(3), CHAD(7), COL11A1(47), COL11A2(18), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), COMP(6), CRK(1), CRKL(2), CTNNB1(27), DIAPH1(14), DOCK1(20), EGF(11), EGFR(19), ELK1(4), ERBB2(23), FARP2(6), FIGF(5), FLNA(28), FLNB(33), FLNC(38), FLT1(19), FN1(33), FYN(9), GRB2(4), GSK3B(6), HGF(20), HRAS(1), IBSP(4), IGF1(2), IGF1R(20), ILK(9), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAV(18), ITGB1(11), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), JUN(5), KDR(17), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), MAP2K1(7), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MET(10), MYL2(9), MYL7(3), MYL9(2), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PARVA(2), PARVB(5), PARVG(5), PDGFA(2), PDGFB(6), PDGFC(8), PDGFD(10), PDGFRA(13), PDGFRB(12), PDPK1(1), PGF(3), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP5K1C(14), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PRKCA(8), PRKCG(17), PTEN(36), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF1(11), RELN(52), RHOA(20), ROCK1(20), ROCK2(16), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SPP1(4), SRC(5), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TLN1(28), TLN2(32), TNC(27), TNN(31), TNR(26), TNXB(68), VASP(2), VAV1(13), VAV2(13), VAV3(14), VCL(11), VEGFB(2), VEGFC(12), VTN(10), VWF(38), ZYX(7)	217369081	2695	338	2535	853	832	388	316	567	564	28	0.000334	1.000	1.000
235	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(53), APC2(16), AXIN1(15), AXIN2(20), BTRC(9), CACYBP(2), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CCND1(2), CCND2(2), CCND3(1), CER1(3), CHD8(27), CREBBP(46), CSNK1A1(5), CSNK1A1L(7), CSNK1E(9), CSNK2A1(5), CSNK2A2(8), CTBP1(5), CTBP2(8), CTNNB1(27), CTNNBIP1(2), CUL1(24), CXXC4(4), DAAM1(15), DAAM2(16), DKK1(12), DKK2(8), DKK4(5), DVL1(8), DVL2(10), DVL3(15), EP300(27), FBXW11(9), FOSL1(1), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD4(9), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GSK3B(6), JUN(5), LEF1(5), LRP5(31), LRP6(8), MAP3K7(11), MAPK10(4), MAPK8(6), MAPK9(5), MMP7(2), MYC(6), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NKD1(8), NKD2(2), NLK(15), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PORCN(5), PPARD(8), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRICKLE1(20), PRICKLE2(20), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PSEN1(5), RAC1(1), RAC2(2), RAC3(4), RBX1(1), RHOA(20), ROCK1(20), ROCK2(16), RUVBL1(9), SENP2(7), SFRP1(7), SFRP2(6), SFRP4(5), SFRP5(1), SIAH1(3), SMAD2(9), SMAD3(6), SMAD4(31), SOX17(13), TBL1X(8), TBL1XR1(8), TBL1Y(2), TCF7(9), TCF7L1(8), TCF7L2(12), TP53(200), VANGL1(5), VANGL2(10), WIF1(3), WNT1(10), WNT10A(6), WNT10B(2), WNT11(3), WNT16(14), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4)	94584557	1538	330	1356	336	500	196	166	258	404	14	<1.00e-15	1.000	1.000
236	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(10), ATM(49), BUB1(13), BUB1B(13), BUB3(4), CCNA1(10), CCNA2(1), CCNB1(3), CCNB3(21), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNH(3), CDAN1(13), CDC14A(19), CDC14B(7), CDC20(7), CDC25A(5), CDC25B(6), CDC25C(11), CDC6(8), CDC7(7), CDH1(33), CDK2(4), CDK4(2), CDKN1A(5), CDKN2A(17), CHEK1(6), CHEK2(10), DTX4(12), E2F1(4), E2F2(5), E2F3(3), E2F4(2), E2F5(4), EP300(27), ESPL1(21), GSK3B(6), HDAC1(9), HDAC2(6), HDAC3(7), HDAC4(29), HDAC5(13), HDAC6(9), HDAC8(3), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), MPEG1(10), MPL(5), PCNA(2), PLK1(16), PRKDC(56), PTPRA(15), PTTG1(2), RB1(14), RBL1(12), SKP2(6), SMAD4(31), TBC1D8(13), TFDP1(5), TGFB1(3), TP53(200), WEE1(6)	64404145	938	323	800	186	249	117	122	181	259	10	2.66e-10	1.000	1.000
237	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY7(18), ADCY8(37), ADCY9(17), ADORA2A(2), ADORA2B(2), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), ATP2A1(12), ATP2A2(4), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(23), ATP2B4(16), AVPR1A(17), AVPR1B(3), BDKRB1(4), BDKRB2(3), BST1(3), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1F(14), CACNA1G(27), CACNA1H(40), CACNA1I(26), CACNA1S(26), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CCKAR(7), CCKBR(16), CD38(5), CHRM1(6), CHRM2(19), CHRM3(12), CHRM5(4), CHRNA7(6), CYSLTR1(8), CYSLTR2(1), DRD1(4), EDNRA(4), EDNRB(33), EGFR(19), ERBB2(23), ERBB3(43), ERBB4(59), F2R(6), GNA11(6), GNA14(5), GNA15(4), GNAL(3), GNAQ(3), GNAS(38), GRIN1(11), GRIN2A(20), GRIN2C(10), GRIN2D(10), GRM1(43), GRM5(37), GRPR(6), HRH1(5), HRH2(6), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), LHCGR(18), LTB4R2(6), MYLK(25), MYLK2(8), NOS1(39), NOS3(15), NTSR1(10), OXTR(8), P2RX1(4), P2RX2(7), P2RX3(7), P2RX4(7), P2RX5(7), P2RX7(2), PDE1A(7), PDE1B(5), PDE1C(14), PDGFRA(13), PDGFRB(12), PHKA1(10), PHKA2(15), PHKB(7), PHKG1(2), PHKG2(11), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PPID(5), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PTAFR(4), PTGER3(8), PTGFR(5), PTK2B(16), RYR1(68), RYR2(106), RYR3(81), SLC25A4(3), SLC25A5(3), SLC25A6(5), SLC8A1(19), SLC8A2(18), SLC8A3(12), SPHK1(10), SPHK2(8), TACR1(4), TACR2(2), TACR3(15), TBXA2R(9), TNNC1(2), TNNC2(1), TRHR(7), TRPC1(11), VDAC1(3), VDAC2(2), VDAC3(7)	157553223	2308	323	2185	712	845	268	302	470	412	11	1.18e-06	1.000	1.000
238	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(10), ANAPC1(17), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC4(2), ANAPC5(5), ANAPC7(6), ATM(49), ATR(28), BUB1(13), BUB1B(13), BUB3(4), CCNA1(10), CCNA2(1), CCNB1(3), CCNB3(21), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNH(3), CDC14A(19), CDC14B(7), CDC16(7), CDC20(7), CDC23(6), CDC25A(5), CDC25B(6), CDC25C(11), CDC26(2), CDC27(5), CDC6(8), CDC7(7), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2A(17), CDKN2B(1), CDKN2C(1), CDKN2D(4), CHEK1(6), CHEK2(10), CREBBP(46), CUL1(24), DBF4(7), E2F1(4), E2F2(5), E2F3(3), EP300(27), ESPL1(21), FZR1(8), GADD45B(1), GSK3B(6), HDAC1(9), HDAC2(6), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), PCNA(2), PKMYT1(6), PLK1(16), PRKDC(56), PTTG1(2), RB1(14), RBL1(12), RBL2(7), RBX1(1), SFN(1), SKP2(6), SMAD2(9), SMAD3(6), SMAD4(31), SMC1A(7), SMC1B(9), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9), TP53(200), WEE1(6), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3)	79647586	1039	319	897	219	276	120	133	201	300	9	2.37e-08	1.000	1.000
239	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(8), ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), ADRA1A(19), ADRA1B(5), ADRA2A(9), ADRA2B(10), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), AGTR2(4), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), C5AR1(6), CALCR(6), CALCRL(10), CCKAR(7), CCKBR(16), CGA(1), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CNR1(13), CNR2(3), CRHR1(12), CRHR2(4), CTSG(4), CYSLTR1(8), CYSLTR2(1), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), EDNRA(4), EDNRB(33), F2(11), F2R(6), F2RL1(1), F2RL2(4), F2RL3(4), FPR1(8), FSHB(1), FSHR(24), GABBR1(18), GABBR2(15), GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), GABRB1(10), GABRB2(6), GABRB3(13), GABRD(8), GABRE(7), GABRG1(11), GABRG2(16), GABRG3(9), GABRP(6), GABRQ(12), GABRR1(7), GABRR2(7), GALR1(6), GALR2(11), GALR3(4), GH1(2), GH2(2), GHR(9), GHRHR(4), GHSR(8), GIPR(6), GLP1R(1), GLP2R(10), GLRA1(7), GLRA2(4), GLRA3(7), GLRB(10), GNRHR(5), GPR156(10), GPR35(5), GPR50(11), GPR63(3), GPR83(4), GRIA1(22), GRIA2(26), GRIA3(11), GRIA4(13), GRID1(23), GRID2(23), GRIK1(12), GRIK2(17), GRIK3(19), GRIK4(14), GRIK5(18), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), GRIN3A(21), GRIN3B(7), GRM1(43), GRM2(27), GRM3(22), GRM4(15), GRM5(37), GRM6(18), GRM7(27), GRM8(27), GRPR(6), GZMA(4), HCRTR1(6), HCRTR2(8), HRH1(5), HRH2(6), HRH3(7), HRH4(8), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), LEP(3), LEPR(14), LHB(3), LHCGR(18), LTB4R(2), LTB4R2(6), MAS1(3), MC1R(6), MC2R(3), MC3R(11), MC4R(6), MC5R(6), MCHR1(8), MCHR2(6), MLNR(4), MTNR1A(4), MTNR1B(8), NMBR(3), NMUR1(6), NMUR2(6), NPBWR1(19), NPBWR2(9), NPFFR1(2), NPFFR2(12), NPY1R(5), NPY2R(7), NPY5R(4), NR3C1(9), NTSR1(10), NTSR2(5), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OXTR(8), P2RX1(4), P2RX2(7), P2RX3(7), P2RX4(7), P2RX5(7), P2RX7(2), P2RY1(3), P2RY10(11), P2RY11(3), P2RY13(4), P2RY14(5), P2RY2(5), P2RY4(13), P2RY6(10), P2RY8(8), PARD3(17), PRL(1), PRLHR(8), PRLR(5), PRSS1(3), PRSS3(3), PTAFR(4), PTGDR(8), PTGER2(7), PTGER3(8), PTGER4(12), PTGFR(5), PTH2R(11), RXFP1(9), RXFP2(12), SCTR(5), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), SSTR5(3), TAAR1(6), TAAR2(4), TAAR5(5), TAAR6(8), TACR1(4), TACR2(2), TACR3(15), TBXA2R(9), THRA(7), THRB(4), TRHR(7), TRPV1(8), TSHB(3), TSHR(12), TSPO(1), UTS2R(4), VIPR1(3), VIPR2(5)	130010615	2065	313	1975	676	740	238	282	508	293	4	4.56e-05	1.000	1.000
240	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(6), ACTN1(7), ACTN2(26), ACTN4(16), APC(53), APC2(16), ARAF(13), ARHGEF1(12), ARHGEF12(14), ARHGEF4(14), ARHGEF6(11), ARHGEF7(10), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), ARPC5L(3), BAIAP2(5), BCAR1(10), BDKRB1(4), BDKRB2(3), BRAF(18), CD14(1), CDC42(3), CFL1(1), CFL2(1), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CRK(1), CRKL(2), CSK(8), CYFIP1(14), CYFIP2(21), DIAPH1(14), DIAPH2(10), DIAPH3(18), DOCK1(20), EGF(11), EGFR(19), EZR(5), F2(11), F2R(6), FGD1(16), FGD3(17), FGF1(3), FGF10(5), FGF11(1), FGF12(9), FGF13(15), FGF14(7), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(3), FGF3(1), FGF5(4), FGF6(7), FGF7(5), FGF8(1), FGF9(10), FGFR1(18), FGFR2(11), FGFR3(9), FGFR4(18), FN1(33), GIT1(4), GNA12(1), GNA13(7), GNG12(12), GSN(12), HRAS(1), IQGAP1(15), IQGAP2(13), IQGAP3(19), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAD(17), ITGAE(16), ITGAL(22), ITGAM(10), ITGAV(18), ITGAX(13), ITGB1(11), ITGB2(12), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), KRAS(37), LIMK1(6), LIMK2(3), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MOS(11), MRAS(4), MSN(11), MYH10(36), MYH14(24), MYH9(42), MYL2(9), MYL7(3), MYL9(2), MYLK(25), MYLK2(8), NCKAP1(13), NCKAP1L(14), NRAS(4), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDGFA(2), PDGFB(6), PDGFRA(13), PDGFRB(12), PFN1(1), PFN2(1), PFN3(3), PFN4(1), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PPP1R12B(16), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RDX(7), RHOA(20), ROCK1(20), ROCK2(16), RRAS(1), RRAS2(3), SCIN(10), SLC9A1(12), SOS1(9), SOS2(18), SSH1(13), SSH2(22), SSH3(11), TIAM1(38), TIAM2(25), VAV1(13), VAV2(13), VAV3(14), VCL(11), WAS(4), WASF1(8), WASF2(7), WASL(5)	161732935	2024	312	1862	579	651	287	263	367	441	15	2.05e-06	1.000	1.000
241	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(8), ACTG1(1), CHAD(7), COL11A1(47), COL11A2(18), COL17A1(13), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), COMP(6), DES(3), DSC1(2), DSC2(13), DSC3(7), DSG1(5), DSG2(6), DSG3(15), DSG4(7), FN1(33), GJA1(13), GJA10(5), GJA3(4), GJA4(8), GJA5(7), GJA8(8), GJA9(2), GJB1(2), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GJB7(3), GJC1(5), GJC2(4), GJD2(8), GJD4(3), IBSP(4), INA(7), ITGA6(10), ITGB4(24), KRT1(7), KRT10(5), KRT12(5), KRT13(10), KRT14(3), KRT15(3), KRT16(11), KRT17(7), KRT18(3), KRT19(5), KRT2(12), KRT20(4), KRT23(10), KRT24(6), KRT25(8), KRT27(11), KRT28(11), KRT3(10), KRT31(6), KRT32(6), KRT33A(10), KRT33B(8), KRT34(9), KRT35(7), KRT36(6), KRT37(2), KRT38(3), KRT39(8), KRT4(7), KRT40(3), KRT5(6), KRT6A(12), KRT6B(7), KRT6C(11), KRT7(5), KRT71(3), KRT72(14), KRT73(16), KRT74(7), KRT75(40), KRT76(5), KRT77(2), KRT78(4), KRT79(8), KRT8(7), KRT81(5), KRT82(6), KRT83(4), KRT84(7), KRT85(5), KRT86(4), KRT9(2), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), LMNA(11), LMNB1(4), LMNB2(6), NES(17), PRPH(5), RELN(52), SPP1(4), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNC(27), TNN(31), TNR(26), TNXB(68), VIM(10), VTN(10), VWF(38)	145932319	1803	308	1728	675	573	254	187	431	341	17	0.751	1.000	1.000
242	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(22), CD36(5), CD44(8), CD47(1), CHAD(7), COL11A1(47), COL11A2(18), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), DAG1(13), FN1(33), FNDC1(24), FNDC3A(10), FNDC4(6), FNDC5(3), GP5(14), GP6(4), GP9(3), HMMR(9), HSPG2(73), IBSP(4), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAV(18), ITGB1(11), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), RELN(52), SDC1(2), SDC2(2), SDC3(4), SDC4(5), SPP1(4), SV2A(18), SV2B(7), SV2C(12), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNC(27), TNN(31), TNR(26), TNXB(68), VTN(10), VWF(38)	131162178	1637	294	1555	540	508	216	163	388	346	16	0.0586	1.000	1.000
243	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(10), ABLIM1(14), ABLIM2(14), ABLIM3(7), ARHGEF12(14), CDC42(3), CDK5(3), CFL1(1), CFL2(1), DCC(35), DPYSL2(4), DPYSL5(12), EFNA1(2), EFNA2(2), EFNA4(5), EFNA5(5), EFNB1(5), EFNB2(5), EFNB3(13), EPHA1(15), EPHA2(28), EPHA3(32), EPHA4(17), EPHA5(32), EPHA6(32), EPHA7(13), EPHA8(17), EPHB1(33), EPHB2(15), EPHB3(13), EPHB4(17), EPHB6(22), FES(13), FYN(9), GNAI1(3), GNAI2(4), GNAI3(8), GSK3B(6), HRAS(1), ITGB1(11), KRAS(37), L1CAM(18), LIMK1(6), LIMK2(3), LRRC4C(4), MAPK1(3), MAPK3(3), MET(10), NCK1(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NGEF(7), NRAS(4), NRP1(13), NTN1(7), NTN4(4), NTNG1(24), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PLXNA1(39), PLXNA2(24), PLXNA3(24), PLXNB1(30), PLXNB2(22), PLXNB3(13), PLXNC1(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTK2(11), RAC1(1), RAC2(2), RAC3(4), RASA1(19), RGS3(16), RHOA(20), RHOD(2), RND1(2), ROBO1(37), ROBO2(36), ROBO3(16), ROCK1(20), ROCK2(16), SEMA3A(16), SEMA3C(7), SEMA3D(17), SEMA3E(19), SEMA3F(11), SEMA3G(6), SEMA4A(11), SEMA4B(1), SEMA4C(13), SEMA4D(13), SEMA4F(9), SEMA4G(5), SEMA5A(28), SEMA5B(26), SEMA6A(17), SEMA6B(8), SEMA6C(11), SEMA6D(26), SEMA7A(9), SLIT1(9), SLIT2(38), SLIT3(21), SRGAP1(14), SRGAP3(12), UNC5A(14), UNC5B(11), UNC5C(19), UNC5D(24)	115257765	1597	292	1502	462	485	209	207	354	332	10	5.17e-05	1.000	1.000
244	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), AKT1(3), AKT2(10), AKT3(8), AMOTL1(11), ASH1L(40), CASK(7), CDC42(3), CDK4(2), CGN(16), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CRB3(2), CSNK2A1(5), CSNK2A2(8), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), CTTN(12), EPB41(15), EPB41L1(10), EPB41L2(12), EPB41L3(39), EXOC3(6), EXOC4(12), F11R(2), GNAI1(3), GNAI2(4), GNAI3(8), HCLS1(3), HRAS(1), IGSF5(5), INADL(18), JAM2(2), JAM3(6), KRAS(37), LLGL1(10), LLGL2(9), MAGI1(26), MAGI2(28), MAGI3(11), MLLT4(29), MPDZ(30), MPP5(4), MRAS(4), MYH1(22), MYH10(36), MYH11(31), MYH13(28), MYH14(24), MYH15(14), MYH2(39), MYH3(32), MYH4(25), MYH6(24), MYH7(35), MYH7B(20), MYH8(20), MYH9(42), MYL2(9), MYL7(3), MYL9(2), NRAS(4), OCLN(8), PARD3(17), PARD6B(3), PARD6G(2), PPM1J(2), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PPP2R3A(11), PPP2R3B(15), PPP2R4(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), PTEN(36), RAB13(3), RAB3B(4), RHOA(20), RRAS(1), RRAS2(3), SPTAN1(22), SRC(5), SYMPK(10), TJAP1(4), TJP1(26), TJP2(17), TJP3(11), VAPA(3), YES1(4), ZAK(8)	113799022	1461	282	1367	427	462	199	181	324	287	8	0.000764	1.000	1.000
245	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(12), CADM1(21), CADM3(13), CD2(4), CD22(5), CD226(2), CD274(4), CD276(8), CD28(1), CD34(4), CD4(11), CD40(3), CD40LG(5), CD58(7), CD6(11), CD80(5), CD86(7), CD8A(4), CD8B(2), CD99(1), CDH1(33), CDH15(10), CDH2(20), CDH3(12), CDH4(25), CDH5(12), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CNTN1(23), CNTN2(12), CNTNAP1(20), CNTNAP2(40), CTLA4(4), ESAM(6), F11R(2), GLG1(18), HLA-A(22), HLA-B(29), HLA-C(7), HLA-DMA(1), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(4), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), HLA-E(6), HLA-F(8), HLA-G(5), ICAM1(4), ICAM2(3), ICAM3(5), ICOS(4), ICOSLG(2), ITGA4(16), ITGA6(10), ITGA8(12), ITGA9(9), ITGAL(22), ITGAM(10), ITGAV(18), ITGB1(11), ITGB2(12), ITGB7(6), ITGB8(18), JAM2(2), JAM3(6), L1CAM(18), MADCAM1(2), MAG(21), MPZ(2), MPZL1(2), NCAM1(9), NCAM2(27), NEGR1(9), NEO1(16), NFASC(36), NLGN1(21), NLGN2(10), NLGN3(13), NRCAM(12), NRXN1(43), NRXN2(30), NRXN3(37), OCLN(8), PDCD1(5), PDCD1LG2(2), PTPRC(21), PTPRF(21), PTPRM(34), PVR(3), PVRL1(4), PVRL2(9), PVRL3(6), SDC1(2), SDC2(2), SDC3(4), SDC4(5), SELE(6), SELL(6), SELP(11), SELPLG(9), SIGLEC1(22), SPN(4), VCAM1(9), VCAN(45)	86443972	1258	278	1183	361	362	172	165	270	283	6	9.83e-06	1.000	1.000
246	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRB1(9), ADRB2(8), ADRB3(6), ANXA6(3), ARRB1(3), ARRB2(2), ATP1A4(21), ATP1B1(7), ATP1B2(4), ATP1B3(4), ATP2A2(4), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(23), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1S(26), CACNB1(4), CACNB3(4), CALM1(2), CALM2(3), CALM3(1), CALR(2), CAMK1(3), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CASQ1(8), CASQ2(3), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), GJA1(13), GJA4(8), GJA5(7), GJB1(2), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GNA11(6), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAZ(17), GNB1(2), GNB2(4), GNB3(2), GNB4(4), GNB5(3), GNG12(12), GNG13(3), GNG2(1), GNG7(4), GNGT1(3), GRK4(11), GRK5(1), GRK6(5), ITPR1(34), ITPR2(33), ITPR3(44), KCNB1(16), KCNJ3(18), KCNJ5(6), MIB1(4), NME7(1), PEA15(1), PKIA(2), PKIG(1), PLCB3(17), PRKACA(6), PRKACB(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RGS1(4), RGS10(5), RGS11(6), RGS14(4), RGS16(3), RGS17(4), RGS18(9), RGS19(4), RGS2(5), RGS20(7), RGS3(16), RGS4(7), RGS5(2), RGS6(14), RGS7(4), RGS9(13), RYR1(68), RYR2(106), RYR3(81), SFN(1), SLC8A1(19), SLC8A3(12), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(4)	109710073	1547	276	1483	524	555	170	208	302	302	10	0.0283	1.000	1.000
247	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(7), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADM(1), ARRB1(3), ARRB2(2), ATF2(4), ATF3(2), ATF4(2), ATF5(5), ATP2A2(4), ATP2A3(11), CACNB3(4), CALCA(2), CALM1(2), CALM2(3), CALM3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CNN1(3), CNN2(1), CORIN(13), CRHR1(12), DGKZ(10), ETS2(4), FOS(1), GABPA(4), GABPB2(4), GBA2(6), GJA1(13), GNAQ(3), GNB1(2), GNB2(4), GNB3(2), GNB4(4), GNB5(3), GNG12(12), GNG13(3), GNG2(1), GNG7(4), GNGT1(3), GRK4(11), GRK5(1), GRK6(5), GSTO1(1), GUCA2A(1), GUCA2B(4), GUCY1A3(17), IGFBP1(11), IGFBP2(5), IGFBP3(5), IGFBP4(1), IGFBP6(1), IL1B(4), ITPR1(34), ITPR2(33), ITPR3(44), JUN(5), MAFF(1), MIB1(4), MYL2(9), MYL4(1), MYLK2(8), NFKB1(8), NOS1(39), NOS3(15), OXT(1), OXTR(8), PDE4B(6), PDE4D(5), PKIA(2), PKIG(1), PLCB3(17), PLCD1(7), PLCG1(22), PLCG2(19), PRKACA(6), PRKACB(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RAMP2(2), RAMP3(3), RGS1(4), RGS10(5), RGS11(6), RGS14(4), RGS16(3), RGS17(4), RGS18(9), RGS19(4), RGS2(5), RGS20(7), RGS3(16), RGS4(7), RGS5(2), RGS6(14), RGS7(4), RGS9(13), RLN1(4), RYR1(68), RYR2(106), RYR3(81), SFN(1), SLC8A1(19), SP1(5), TNXB(68), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(4)	101288116	1318	259	1258	441	460	139	159	276	277	7	0.0783	1.000	1.000
248	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(5), ACVR1B(15), ACVR2A(10), ACVR2B(5), AMHR2(9), BMP2(7), BMP7(7), BMPR1A(12), BMPR1B(9), BMPR2(21), CCL1(3), CCL11(1), CCL13(1), CCL15(2), CCL16(1), CCL18(3), CCL19(2), CCL2(1), CCL20(3), CCL22(2), CCL23(1), CCL24(2), CCL25(1), CCL27(2), CCL3(1), CCL5(3), CCL7(1), CCL8(2), CCR1(7), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CCR9(6), CD27(2), CD40(3), CD40LG(5), CD70(3), CLCF1(3), CNTF(3), CNTFR(6), CRLF2(2), CSF1(5), CSF1R(17), CSF2RA(10), CSF2RB(12), CSF3(1), CSF3R(13), CX3CL1(9), CX3CR1(4), CXCL10(1), CXCL2(2), CXCL5(1), CXCL9(2), CXCR3(2), CXCR6(2), EDA(5), EDA2R(3), EDAR(8), EGF(11), EGFR(19), EPO(3), EPOR(3), FAS(3), FASLG(5), FLT1(19), FLT3(12), FLT3LG(1), FLT4(31), GDF5(13), GH1(2), GH2(2), GHR(9), HGF(20), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL13(4), IL13RA1(5), IL15(1), IL15RA(5), IL17B(3), IL17RA(10), IL17RB(6), IL18(1), IL18R1(6), IL18RAP(3), IL19(1), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), IL1RAP(6), IL20(1), IL20RA(5), IL21(4), IL21R(10), IL22(2), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL25(4), IL26(4), IL2RA(2), IL2RB(3), IL2RG(9), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL6ST(6), IL7(2), IL7R(15), IL9R(2), INHBA(13), INHBB(12), INHBC(7), INHBE(2), KDR(17), KIT(13), KITLG(4), LEP(3), LEPR(14), LIF(4), LIFR(15), LTA(4), LTBR(2), MET(10), MPL(5), NGFR(7), OSM(4), OSMR(10), PDGFB(6), PDGFC(8), PDGFRA(13), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(2), PRL(1), PRLR(5), RELT(8), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFRSF11A(4), TNFRSF11B(5), TNFRSF12A(1), TNFRSF13B(7), TNFRSF13C(4), TNFRSF14(2), TNFRSF17(1), TNFRSF19(8), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(4), TNFRSF25(5), TNFRSF4(5), TNFRSF8(7), TNFRSF9(11), TNFSF10(9), TNFSF11(5), TNFSF13(6), TNFSF13B(4), TNFSF14(3), TNFSF15(5), TNFSF18(2), TNFSF4(1), TNFSF8(4), TPO(27), TSLP(1), VEGFB(2), VEGFC(12), XCL1(1), XCR1(5)	103787609	1161	258	1104	383	307	158	148	260	282	6	0.153	1.000	1.000
249	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(28), ACACB(40), AKT1(3), AKT2(10), AKT3(8), ARAF(13), BAD(4), BRAF(18), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CBL(5), CBLB(2), CBLC(7), CRK(1), CRKL(2), EIF4EBP1(4), ELK1(4), EXOC7(14), FASN(27), FBP1(4), FBP2(6), FLOT2(9), FOXO1(5), G6PC2(1), GCK(9), GRB2(4), GSK3B(6), GYS1(8), GYS2(9), HRAS(1), IKBKB(10), INPP5D(8), INSR(17), IRS1(27), IRS2(10), IRS4(25), KRAS(37), LIPE(7), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MKNK1(5), MKNK2(8), NRAS(4), PCK1(12), PCK2(10), PDE3A(19), PDE3B(23), PDPK1(1), PFKL(8), PFKM(2), PFKP(21), PHKA1(10), PHKA2(15), PHKB(7), PHKG1(2), PHKG2(11), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PKLR(9), PPARGC1A(11), PPP1CA(2), PPP1CC(4), PPP1R3A(31), PPP1R3B(7), PPP1R3C(4), PPP1R3D(4), PRKAA1(7), PRKAA2(10), PRKAB1(11), PRKAB2(4), PRKACA(6), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCI(7), PRKCZ(2), PRKX(6), PTPN1(3), PTPRF(21), PYGB(14), PYGL(11), PYGM(14), RAF1(9), RAPGEF1(11), RHEB(2), RHOQ(5), RPS6(1), RPS6KB1(6), RPS6KB2(9), SH2B2(5), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SLC2A4(5), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SORBS1(12), SOS1(9), SOS2(18), SREBF1(15), TRIP10(11), TSC1(10), TSC2(14)	93739153	1195	255	1067	325	371	196	142	203	275	8	3.52e-06	1.000	1.000
250	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(7), ACTN2(26), ACTN4(16), DES(3), DMD(68), MYBPC1(9), MYBPC2(15), MYBPC3(12), MYH3(32), MYH6(24), MYH7(35), MYH8(20), MYL1(2), MYL2(9), MYL3(4), MYL4(1), MYL9(2), MYOM1(15), NEB(72), TCAP(4), TMOD1(3), TNNC2(1), TNNI1(1), TNNI2(6), TNNT1(6), TNNT2(3), TNNT3(7), TPM1(5), TPM2(2), TPM3(4), TPM4(4), TTN(569), VIM(10)	79893365	1001	255	966	305	269	120	174	322	99	17	0.0336	1.000	1.000
251	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(9), ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), ACVR1B(15), ACVR1C(5), BAIAP2(5), CDC42(3), CDH1(33), CREBBP(46), CSNK2A1(5), CSNK2A2(8), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), CTNND1(26), EGFR(19), EP300(27), ERBB2(23), FARP2(6), FER(14), FGFR1(18), FYN(9), IGF1R(20), INSR(17), IQGAP1(15), LEF1(5), LMO7(22), MAP3K7(11), MAPK1(3), MAPK3(3), MET(10), MLLT4(29), NLK(15), PARD3(17), PTPN1(3), PTPN6(6), PTPRB(26), PTPRF(21), PTPRJ(30), PTPRM(34), PVRL1(4), PVRL2(9), PVRL3(6), PVRL4(10), RAC1(1), RAC2(2), RAC3(4), RHOA(20), SMAD2(9), SMAD3(6), SMAD4(31), SNAI1(2), SNAI2(13), SORBS1(12), SRC(5), SSX2IP(10), TCF7(9), TCF7L1(8), TCF7L2(12), TGFBR1(8), TGFBR2(17), TJP1(26), VCL(11), WAS(4), WASF1(8), WASF2(7), WASF3(20), WASL(5), YES1(4)	70241524	989	253	915	250	275	138	124	198	244	10	7.49e-06	1.000	1.000
252	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRA2A(9), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), AGTR2(4), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), CCKAR(7), CCKBR(16), CCR1(7), CCR10(3), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CCR9(6), CCRL2(1), CHML(8), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CMKLR1(6), CNR1(13), CNR2(3), CX3CR1(4), CXCR3(2), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), EDNRA(4), EDNRB(33), F2R(6), F2RL1(1), F2RL2(4), F2RL3(4), FPR1(8), FSHR(24), GALR1(6), GALR2(11), GALR3(4), GALT(3), GHSR(8), GNB2L1(3), GPR17(6), GPR173(7), GPR174(3), GPR27(8), GPR3(3), GPR35(5), GPR37(13), GPR37L1(8), GPR4(5), GPR50(11), GPR6(11), GPR63(3), GPR83(4), GPR85(4), GPR87(6), GRPR(6), HCRTR1(6), HCRTR2(8), HRH1(5), HRH2(6), HRH3(7), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), LHCGR(18), LTB4R(2), MAS1(3), MC1R(6), MC3R(11), MC4R(6), MC5R(6), MLNR(4), MTNR1A(4), MTNR1B(8), NMBR(3), NMUR1(6), NMUR2(6), NPY1R(5), NPY2R(7), NPY5R(4), NTSR1(10), NTSR2(5), OPN1SW(2), OPN3(4), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OR10A5(5), OR11A1(6), OR12D3(4), OR1C1(5), OR1F1(5), OR1Q1(7), OR2H1(2), OR5V1(7), OR7A5(3), OR7C1(7), OR8B8(7), OXTR(8), P2RY1(3), P2RY10(11), P2RY11(3), P2RY12(10), P2RY13(4), P2RY14(5), P2RY2(5), P2RY6(10), PTAFR(4), PTGDR(8), PTGER2(7), PTGER4(12), PTGFR(5), RGR(3), RHO(9), RRH(3), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), SUCNR1(4), TBXA2R(9), TRHR(7)	71364139	1082	251	1029	401	407	118	161	233	163	0	0.0693	1.000	1.000
253	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(10), ABL2(16), AKT1(3), AKT2(10), AKT3(8), ARAF(13), AREG(2), BAD(4), BRAF(18), BTC(2), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CBL(5), CBLB(2), CBLC(7), CDKN1A(5), CDKN1B(1), CRK(1), CRKL(2), EGF(11), EGFR(19), EIF4EBP1(4), ELK1(4), ERBB2(23), ERBB3(43), ERBB4(59), EREG(3), GAB1(4), GRB2(4), GSK3B(6), HBEGF(2), HRAS(1), JUN(5), KRAS(37), MAP2K1(7), MAP2K2(3), MAP2K4(9), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MYC(6), NCK1(6), NCK2(8), NRAS(4), NRG1(16), NRG2(9), NRG3(24), NRG4(2), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PRKCA(8), PRKCG(17), PTK2(11), RAF1(9), RPS6KB1(6), RPS6KB2(9), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SRC(5), STAT5A(10), STAT5B(13), TGFA(3)	60301365	927	249	794	202	270	163	126	176	186	6	2.25e-11	1.000	1.000
254	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADRB1(9), CSNK1D(4), DRD1(4), DRD2(10), EGF(11), EGFR(19), GJA1(13), GJD2(8), GNA11(6), GNAI1(3), GNAI2(4), GNAI3(8), GNAQ(3), GNAS(38), GRB2(4), GRM1(43), GRM5(37), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), HRAS(1), HTR2A(8), HTR2B(5), HTR2C(10), ITPR1(34), ITPR2(33), ITPR3(44), KRAS(37), MAP2K1(7), MAP2K2(3), MAP2K5(1), MAP3K2(6), MAPK1(3), MAPK3(3), MAPK7(8), NPR1(11), NPR2(10), NRAS(4), PDGFA(2), PDGFB(6), PDGFC(8), PDGFD(10), PDGFRA(13), PDGFRB(12), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKG1(12), PRKG2(15), PRKX(6), RAF1(9), SOS1(9), SOS2(18), SRC(5), TJP1(26), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9)	77500575	1068	248	998	349	342	165	128	245	182	6	0.0303	1.000	1.000
255	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(10), AKT3(8), BCL2L1(1), CBL(5), CBLB(2), CBLC(7), CCND1(2), CCND2(2), CCND3(1), CISH(4), CLCF1(3), CNTF(3), CNTFR(6), CREBBP(46), CRLF2(2), CSF2RA(10), CSF2RB(12), CSF3(1), CSF3R(13), EP300(27), EPO(3), EPOR(3), GH1(2), GH2(2), GHR(9), GRB2(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL13(4), IL13RA1(5), IL13RA2(7), IL15(1), IL15RA(5), IL19(1), IL20(1), IL20RA(5), IL21(4), IL21R(10), IL22(2), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL26(4), IL2RA(2), IL2RB(3), IL2RG(9), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL6ST(6), IL7(2), IL7R(15), IL9R(2), IRF9(7), JAK1(19), JAK2(12), JAK3(12), LEP(3), LEPR(14), LIF(4), LIFR(15), MPL(5), MYC(6), OSM(4), OSMR(10), PIAS1(10), PIAS2(14), PIAS3(10), PIAS4(8), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIM1(2), PRL(1), PRLR(5), PTPN11(8), PTPN6(6), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SOCS5(5), SOCS7(5), SOS1(9), SOS2(18), SPRED1(13), SPRED2(9), SPRY1(2), SPRY3(8), SPRY4(6), STAM(9), STAM2(6), STAT1(11), STAT2(6), STAT3(7), STAT4(9), STAT5A(10), STAT5B(13), STAT6(7), TPO(27), TSLP(1), TYK2(12)	85135139	980	242	883	279	247	146	154	201	227	5	0.00494	1.000	1.000
256	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(7), ACTN2(26), ACTN4(16), ARHGAP5(26), BCAR1(10), CD99(1), CDC42(3), CDH5(12), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), CTNND1(26), CYBA(1), CYBB(8), ESAM(6), EZR(5), F11R(2), GNAI1(3), GNAI2(4), GNAI3(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGAM(10), ITGB1(11), ITGB2(12), ITK(5), JAM2(2), JAM3(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MLLT4(29), MMP2(10), MMP9(20), MSN(11), MYL2(9), MYL7(3), MYL9(2), NCF1(3), NCF2(3), NCF4(3), NOX1(7), NOX3(7), OCLN(8), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PRKCA(8), PRKCG(17), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAC1(1), RAC2(2), RAP1A(3), RAP1B(6), RAPGEF3(4), RAPGEF4(15), RASSF5(4), RHOA(20), RHOH(1), ROCK1(20), ROCK2(16), SIPA1(9), THY1(1), TXK(2), VASP(2), VAV1(13), VAV2(13), VAV3(14), VCAM1(9), VCL(11)	72767133	986	241	887	270	305	140	130	182	218	11	2.55e-05	1.000	1.000
257	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(13), BRAF(18), CACNA1A(34), CRHR1(12), GNA11(6), GNA12(1), GNA13(7), GNAI1(3), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAS(38), GNAZ(17), GRIA1(22), GRIA2(26), GRIA3(11), GRID2(23), GRM1(43), GRM5(37), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), HRAS(1), IGF1(2), IGF1R(20), ITPR1(34), ITPR2(33), ITPR3(44), KRAS(37), LYN(7), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), NOS1(39), NOS3(15), NPR1(11), NPR2(10), NRAS(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PRKCA(8), PRKCG(17), PRKG1(12), PRKG2(15), RAF1(9), RYR1(68)	64514207	975	238	889	265	326	139	118	230	155	7	2.94e-05	1.000	1.000
258	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(10), ACTN1(7), ACTR2(2), ACTR3(2), AKT1(3), AKT2(10), AKT3(8), ANGPTL2(6), ARHGEF6(11), ARHGEF7(10), BCAR1(10), BRAF(18), CAV1(5), CDC42(3), CDKN2A(17), CRK(1), CSE1L(7), DOCK1(20), EPHB2(15), FYN(9), GRB2(4), GRB7(6), ILK(9), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGB3BP(1), MAP2K4(9), MAP2K7(38), MAP3K11(9), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MRAS(4), MYLK(25), MYLK2(8), P4HB(3), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PIK3CA(80), PIK3CB(13), PKLR(9), PLCG1(22), PLCG2(19), PTEN(36), PTK2(11), RAF1(9), RHO(9), ROCK1(20), ROCK2(16), SHC1(7), SOS1(9), SOS2(18), SRC(5), TERF2IP(5), TLN1(28), TLN2(32), VASP(2), WAS(4), ZYX(7)	71632210	879	236	804	228	280	135	105	142	205	12	2.32e-05	1.000	1.000
259	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(6), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADK(4), ADSL(5), ADSS(6), ADSSL1(9), AK1(1), AK5(5), AK7(5), ALLC(6), AMPD1(12), AMPD2(17), AMPD3(19), APRT(3), ATIC(5), CANT1(5), DCK(4), DGUOK(4), ENPP1(7), ENPP3(12), ENTPD1(4), ENTPD2(6), ENTPD3(6), ENTPD4(13), ENTPD5(2), ENTPD6(6), ENTPD8(7), FHIT(1), GART(10), GDA(6), GMPR(3), GMPR2(1), GMPS(7), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), GUK1(4), IMPDH1(6), ITPA(1), NME2(3), NME4(2), NME6(3), NME7(1), NPR1(11), NPR2(10), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT2(5), NUDT5(1), NUDT9(2), PAPSS1(6), PAPSS2(6), PDE10A(18), PDE11A(11), PDE1A(7), PDE1C(14), PDE2A(16), PDE3B(23), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE5A(7), PDE6D(1), PDE6G(1), PDE6H(1), PDE7A(6), PDE7B(4), PDE8A(13), PDE8B(6), PDE9A(8), PFAS(12), PKLR(9), PNPT1(5), POLA1(8), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), PPAT(7), PRIM1(2), PRIM2(7), PRPS1(3), PRPS2(3), PRUNE(5), RFC5(2), RRM1(5), RRM2(3), RRM2B(4), XDH(23), ZNRD1(2)	95626467	1029	235	997	337	315	134	156	218	203	3	0.144	1.000	1.000
260	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), AKAP1(3), AKAP10(3), AKAP11(17), AKAP12(20), AKAP2(16), AKAP3(11), AKAP4(11), AKAP5(1), AKAP6(32), AKAP7(2), AKAP8(11), AKAP9(41), ARHGEF1(12), CALM1(2), CALM2(3), CALM3(1), CHMP1B(1), GNA11(6), GNA12(1), GNA13(7), GNA14(5), GNA15(4), GNAI2(4), GNAI3(8), GNAL(3), GNAO1(1), GNAQ(3), GNAZ(17), GNB1(2), GNB2(4), GNB3(2), GNB5(3), GNG10(1), GNG12(12), GNG13(3), GNG7(4), GNGT1(3), GNGT2(3), HRAS(1), IL18BP(2), ITPR1(34), KCNJ3(18), KRAS(37), NRAS(4), PALM2(8), PDE1A(7), PDE1B(5), PDE1C(14), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE7A(6), PDE7B(4), PDE8A(13), PDE8B(6), PLCB3(17), PPP3CA(13), PPP3CC(6), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), PRKD1(23), PRKD3(6), RHOA(20), RRAS(1), SLC9A1(12), USP5(6)	68517235	877	234	797	270	243	133	128	190	180	3	0.0120	1.000	1.000
261	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ATF4(2), CACNA1C(44), CACNA1D(43), CACNA1F(14), CACNA1S(26), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CDC42(3), CGA(1), EGFR(19), ELK1(4), FSHB(1), GNA11(6), GNAQ(3), GNAS(38), GNRH1(2), GNRH2(2), GNRHR(5), GRB2(4), HBEGF(2), HRAS(1), ITPR1(34), ITPR2(33), ITPR3(44), JUN(5), KRAS(37), LHB(3), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP2K7(38), MAP3K1(16), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK7(8), MAPK8(6), MAPK9(5), MMP14(7), MMP2(10), NRAS(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLD1(22), PLD2(19), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCD(10), PRKX(6), PTK2B(16), RAF1(9), SOS1(9), SOS2(18), SRC(5)	74436188	1020	232	950	309	341	150	121	200	197	11	0.00129	1.000	1.000
262	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(5), ACVR1B(15), ACVRL1(7), AKT1(3), AURKB(5), BMPR1A(12), BMPR2(21), BUB1(13), CDIPT(1), CDKL2(4), CDS1(5), CDS2(3), CLK1(4), CLK2(15), CLK4(5), COL4A3BP(5), CSNK2A1(5), CSNK2A2(8), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), IMPA1(7), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPPL1(27), ITPKA(2), ITPKB(14), MAP3K10(13), MOS(11), NEK1(6), NEK3(2), OCRL(10), PAK4(9), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3CA(80), PIK3CB(13), PIK3CG(24), PIM2(2), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCG1(22), PLCG2(19), PLK3(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), PRKG1(12), RAF1(9), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KB1(6), STK11(6), TGFBR1(8), VRK1(2)	66015677	845	230	757	182	233	115	127	153	210	7	4.35e-08	1.000	1.000
263	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(2), CALM2(3), CALM3(1), CALML3(1), CDIPT(1), CDS1(5), CDS2(3), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), FN3K(4), IMPA1(7), IMPA2(2), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPP5B(10), INPP5D(8), INPP5E(8), INPPL1(27), ITPK1(6), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), OCRL(10), PI4KA(22), PI4KB(10), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3C3(16), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PRKCA(8), PRKCG(17), PTEN(36), PTPMT1(1), SYNJ1(11), SYNJ2(20)	72886715	893	229	791	209	270	122	124	162	203	12	1.59e-07	1.000	1.000
264	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(13), BID(2), BRAF(18), CASP3(2), CD244(2), CD247(4), FAS(3), FASLG(5), FCGR3A(5), FYN(9), GRB2(4), GZMB(2), HCST(1), HLA-A(22), HLA-B(29), HLA-C(7), HLA-E(6), HLA-G(5), HRAS(1), ICAM1(4), ICAM2(3), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), ITGAL(22), ITGB2(12), KIR2DL3(4), KIR3DL1(10), KIR3DL2(3), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), KLRK1(5), KRAS(37), LAT(3), LCK(4), LCP2(10), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MICA(2), MICB(5), NCR1(3), NCR2(4), NCR3(1), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NRAS(4), PAK1(5), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRF1(13), PRKCA(8), PRKCG(17), PTK2B(16), PTPN11(8), PTPN6(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SH2D1A(1), SH2D1B(1), SH3BP2(7), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SYK(9), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFSF10(9), TYROBP(4), ULBP1(5), ULBP2(1), ULBP3(1), VAV1(13), VAV2(13), VAV3(14), ZAP70(13)	66497158	943	229	810	213	240	159	125	183	230	6	2.42e-10	1.000	1.000
265	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(10), AKT3(8), BCL10(2), CARD11(27), CBL(5), CBLB(2), CBLC(7), CD247(4), CD28(1), CD3E(2), CD4(11), CD40LG(5), CD8A(4), CD8B(2), CDC42(3), CDK4(2), CHUK(5), CTLA4(4), FOS(1), FYN(9), GRAP2(5), GRB2(4), HRAS(1), ICOS(4), IFNG(2), IKBKB(10), IL10(2), IL4(4), ITK(5), JUN(5), KRAS(37), LAT(3), LCK(4), LCP2(10), MALT1(3), MAP3K8(2), NCK1(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(4), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDCD1(5), PDK1(3), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKCQ(14), PTPN6(6), PTPRC(21), RASGRP1(7), RHOA(20), SOS1(9), SOS2(18), TEC(4), TNF(3), VAV1(13), VAV2(13), VAV3(14), ZAP70(13)	59500548	781	228	666	193	219	139	112	153	155	3	1.37e-06	1.000	1.000
266	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(21), ADCY8(37), ARAF(13), ATF4(2), BRAF(18), CACNA1C(44), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CREBBP(46), EP300(27), GNAQ(3), GRIA1(22), GRIA2(26), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), GRM1(43), GRM5(37), HRAS(1), ITPR1(34), ITPR2(33), ITPR3(44), KRAS(37), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), NRAS(4), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PPP1R1A(1), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF3(4), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA6(20)	58236784	847	226	780	238	255	133	109	175	168	7	6.48e-05	1.000	1.000
267	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ASIP(2), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CREB1(4), CREB3L1(5), CREB3L2(4), CREB3L3(6), CREB3L4(3), CREBBP(46), CTNNB1(27), DCT(16), DVL1(8), DVL2(10), DVL3(15), EDN1(4), EDNRB(33), EP300(27), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD4(9), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GNAI1(3), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAS(38), GSK3B(6), HRAS(1), KIT(13), KITLG(4), KRAS(37), LEF1(5), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MC1R(6), MITF(11), NRAS(4), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), POMC(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), RAF1(9), TCF7(9), TCF7L1(8), TCF7L2(12), TYR(15), TYRP1(9), WNT1(10), WNT10A(6), WNT10B(2), WNT11(3), WNT16(14), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4)	63871358	983	219	885	297	342	138	121	180	198	4	0.000615	1.000	1.000
268	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(5), ACVR1B(15), ACVR1C(5), ACVR2A(10), ACVR2B(5), ACVRL1(7), AMHR2(9), BMP2(7), BMP4(6), BMP5(11), BMP6(12), BMP7(7), BMP8A(1), BMP8B(3), BMPR1A(12), BMPR1B(9), BMPR2(21), CDKN2B(1), CHRD(10), COMP(6), CREBBP(46), CUL1(24), DCN(10), E2F4(2), E2F5(4), EP300(27), FST(5), GDF5(13), GDF6(19), GDF7(4), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(13), INHBB(12), INHBC(7), INHBE(2), LEFTY1(3), LEFTY2(3), LTBP1(22), MAPK1(3), MAPK3(3), MYC(6), NODAL(1), NOG(2), PITX2(5), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), RBL1(12), RBL2(7), RBX1(1), RHOA(20), ROCK1(20), ROCK2(16), RPS6KB1(6), RPS6KB2(9), SMAD1(4), SMAD2(9), SMAD3(6), SMAD4(31), SMAD5(2), SMAD6(7), SMAD7(7), SMAD9(13), SMURF1(7), SMURF2(5), SP1(5), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNF(3), ZFYVE16(14), ZFYVE9(10)	57977819	783	216	735	219	230	91	106	139	211	6	0.00547	1.000	1.000
269	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(10), AKT3(8), CASP8(18), CCL3(1), CCL5(3), CD14(1), CD40(3), CD80(5), CD86(7), CHUK(5), CXCL10(1), CXCL9(2), FADD(3), FOS(1), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IKBKB(10), IKBKE(12), IL12A(3), IL12B(2), IL1B(4), IRAK1(7), IRAK4(3), IRF3(3), IRF5(6), IRF7(4), JUN(5), LBP(3), LY96(5), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP2K7(38), MAP3K7(11), MAP3K8(2), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK9(5), MYD88(4), NFKB1(8), NFKB2(9), NFKBIA(1), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), RAC1(1), RELA(7), RIPK1(3), SPP1(4), STAT1(11), TBK1(8), TICAM1(8), TIRAP(1), TLR1(8), TLR2(4), TLR3(6), TLR4(27), TLR5(11), TLR6(4), TLR7(6), TLR8(13), TLR9(15), TNF(3), TOLLIP(6), TRAF3(7), TRAF6(6)	52553952	653	214	580	160	173	92	105	134	144	5	1.80e-05	1.000	1.000
270	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2L1(1), CDC42(3), CDK2(4), CDKN1B(1), CDKN2A(17), CREB1(4), CREB5(7), EBP(2), ERBB4(59), F2RL2(4), GAB1(4), GRB2(4), GSK3A(4), GSK3B(6), IFI27(1), IGF1(2), IGFBP1(11), INPPL1(27), IRS1(27), IRS2(10), IRS4(25), MET(10), MYC(6), NOLC1(12), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PARD3(17), PDK1(3), PIK3CA(80), PIK3CD(15), PPP1R13B(15), PREX1(21), PTEN(36), PTK2(11), PTPN1(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SLC2A4(5), SOS1(9), SOS2(18), TSC1(10), TSC2(14), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3)	45360712	644	210	555	145	170	96	92	116	163	7	4.26e-06	1.000	1.000
271	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(6), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADK(4), ADSL(5), ADSS(6), AK1(1), AK5(5), ALLC(6), AMPD1(12), AMPD2(17), AMPD3(19), APRT(3), ATIC(5), ATP1B1(7), ATP5A1(3), ATP5B(9), ATP5C1(5), ATP5F1(3), ATP5G2(2), ATP5G3(2), ATP5J(3), ATP5J2(1), CANT1(5), DCK(4), DGUOK(4), ENPP1(7), ENPP3(12), ENTPD1(4), ENTPD2(6), FHIT(1), GART(10), GDA(6), GMPS(7), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), GUK1(4), IMPDH1(6), ITPA(1), NME2(3), NPR1(11), NPR2(10), NT5E(5), NT5M(6), NUDT2(5), PAPSS1(6), PAPSS2(6), PDE1A(7), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE5A(7), PDE6B(14), PDE6C(5), PDE6G(1), PDE7B(4), PDE8A(13), PDE9A(8), PFAS(12), PKLR(9), POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14), PPAT(7), PRPS1(3), PRPS2(3), PRUNE(5), RRM1(5), RRM2(3)	75053874	817	209	792	274	236	118	127	172	161	3	0.293	1.000	1.000
272	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(10), AKT3(8), BTK(4), FCER1A(5), FYN(9), GAB2(12), GRB2(4), HRAS(1), IL13(4), IL3(1), IL4(4), INPP5D(8), KRAS(37), LAT(3), LCP2(10), LYN(7), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK9(5), MS4A2(2), NRAS(4), PDK1(3), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCG1(22), PLCG2(19), PRKCA(8), PRKCD(10), PRKCE(14), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SOS1(9), SOS2(18), SYK(9), TNF(3), VAV1(13), VAV2(13), VAV3(14)	42224578	628	206	520	132	178	116	91	128	111	4	6.57e-10	1.000	1.000
273	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(8), BCAR1(10), CAPN1(7), CAPN10(10), CAPN11(6), CAPN2(10), CAPN3(8), CAPN5(12), CAPN6(7), CAPN7(6), CAPN9(5), CAPNS1(3), CAV1(5), CAV2(1), CAV3(2), CDC42(3), CRK(1), CSK(8), DOCK1(20), FYN(9), GIT2(5), GRB2(4), ILK(9), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAD(17), ITGAE(16), ITGAL(22), ITGAM(10), ITGAV(18), ITGAX(13), ITGB1(11), ITGB2(12), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAPK10(4), MAPK12(1), MAPK4(8), MAPK6(3), MAPK7(8), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PDPK1(1), PIK3R2(13), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(11), RHO(9), ROCK1(20), ROCK2(16), SDCCAG8(7), SHC1(7), SHC3(12), SORBS1(12), SOS1(9), SRC(5), TLN1(28), TNS1(39), VASP(2), VAV2(13), VAV3(14), VCL(11), ZYX(7)	78342943	849	206	823	249	274	111	107	151	200	6	0.00345	1.000	1.000
274	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(14), AMY2A(7), AMY2B(18), ASCC3(37), ATP13A2(16), DDX18(14), DDX19A(5), DDX23(12), DDX4(9), DDX41(9), DDX47(1), DDX50(12), DDX51(7), DDX52(7), DDX54(17), DDX55(5), DDX56(8), DHX58(11), ENPP1(7), ENPP3(12), ENTPD7(10), EP400(47), ERCC2(9), ERCC3(8), G6PC2(1), GAA(8), GANC(9), GBA(12), GBE1(7), GCK(9), GPI(6), GUSB(10), GYS1(8), GYS2(9), HK1(17), HK2(12), HK3(11), IFIH1(10), LYZL1(4), MGAM(19), MOV10L1(9), NUDT5(1), NUDT8(1), PGM1(3), PGM3(13), PYGB(14), PYGL(11), PYGM(14), RAD54B(3), RAD54L(4), RUVBL2(9), SETX(24), SI(35), SKIV2L2(13), SMARCA2(31), SMARCA5(10), TREH(3), UGDH(8), UGP2(9), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), UXS1(8)	72395410	772	201	741	219	203	88	114	175	189	3	0.0505	1.000	1.000
275	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(25), ABCA10(21), ABCA12(44), ABCA13(63), ABCA2(27), ABCA3(21), ABCA4(22), ABCA5(24), ABCA6(18), ABCA7(22), ABCA8(14), ABCA9(19), ABCB1(33), ABCB10(14), ABCB11(11), ABCB4(29), ABCB5(21), ABCB6(12), ABCB7(5), ABCB8(13), ABCB9(5), ABCC1(14), ABCC10(14), ABCC11(20), ABCC12(18), ABCC2(17), ABCC3(14), ABCC4(20), ABCC5(11), ABCC6(17), ABCC8(23), ABCC9(45), ABCD1(10), ABCD2(5), ABCD3(4), ABCD4(8), ABCG1(13), ABCG2(5), ABCG4(4), ABCG5(3), ABCG8(6), CFTR(15), TAP1(5), TAP2(10)	69095352	764	199	726	196	219	109	101	153	175	7	9.26e-06	1.000	1.000
276	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(10), AKT3(8), BAD(4), CASP9(3), CDC42(3), HRAS(1), KDR(17), KRAS(37), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPKAPK2(3), MAPKAPK3(5), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NOS3(15), NRAS(4), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCG1(22), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKCA(8), PRKCG(17), PTGS2(7), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SH2D2A(7), SHC2(3), SPHK1(10), SPHK2(8), SRC(5)	42137879	603	198	493	121	183	115	84	114	106	1	5.40e-12	1.000	1.000
277	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(8), ALG6(4), CCKBR(16), CCR2(5), CCR3(12), CCR5(4), CELSR1(43), CELSR2(41), CELSR3(58), CHRM2(19), CHRM3(12), CIDEB(2), CXCR3(2), DRD4(5), EDNRA(4), EMR2(10), EMR3(4), F2R(6), FSHR(24), GHRHR(4), GNRHR(5), GPR116(14), GPR132(5), GPR133(16), GPR135(11), GPR143(4), GPR17(6), GPR18(3), GPR55(9), GPR56(10), GPR61(9), GPR84(3), GRM1(43), GRPR(6), HRH4(8), LGR6(15), LPHN2(23), LPHN3(23), LTB4R2(6), NTSR1(10), OR2M4(6), P2RY11(3), P2RY13(4), PTGFR(5), SMO(15), SSTR2(4), TAAR5(5), TSHR(12), VN1R1(4)	38993861	570	194	552	152	186	77	74	142	89	2	2.97e-05	1.000	1.000
278	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(8), BAD(4), BCL2(4), CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAMK2B(7), CAMK4(10), CD3E(2), CD69(4), CDKN1A(5), CNR1(13), CREBBP(46), CSNK2A1(5), CTLA4(4), EGR2(9), EGR3(9), EP300(27), FCER1A(5), FCGR3A(5), FOS(1), FOSL1(1), GATA3(19), GATA4(4), GSK3A(4), GSK3B(6), HRAS(1), ICOS(4), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL13(4), IL1B(4), IL2RA(2), IL3(1), IL4(4), ITK(5), JUNB(5), KPNA5(8), MAP2K7(38), MAPK14(2), MAPK8(6), MAPK9(5), MEF2A(2), MEF2B(6), MEF2D(8), MYF5(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB2(9), NFKBIB(8), NFKBIE(1), NPPB(3), NUP214(29), OPRD1(4), P2RX7(2), PAK1(5), PIN1(2), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTPRC(21), RELA(7), RPL13A(4), SFN(1), SLA(6), SP1(5), SP3(5), TGFB1(3), TNF(3), TRAF2(4), TRPV6(9), VAV1(13), VAV2(13), VAV3(14), XPO5(4)	53400927	621	193	593	184	193	88	81	120	135	4	0.00837	1.000	1.000
279	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(10), AKT3(8), BCL10(2), BLNK(5), BTK(4), CARD11(27), CD19(5), CD22(5), CD72(1), CD79A(8), CD79B(3), CD81(6), CHUK(5), CR2(25), FCGR2B(3), FOS(1), GSK3B(6), HRAS(1), IFITM1(4), IKBKB(10), INPP5D(8), JUN(5), KRAS(37), LILRB3(6), LYN(7), MALT1(3), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(4), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTPN6(6), RAC1(1), RAC2(2), RAC3(4), RASGRP3(6), SYK(9), VAV1(13), VAV2(13), VAV3(14)	43634866	607	193	499	138	172	121	88	106	118	2	2.92e-08	1.000	1.000
280	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(2), AKT1(3), AKT2(10), AKT3(8), ANGPTL2(6), ARHGAP1(8), ARHGAP4(4), ARHGEF11(25), BTK(4), CDC42(3), CFL1(1), CFL2(1), GDI1(5), GDI2(6), INPPL1(27), ITPR1(34), ITPR2(33), ITPR3(44), LIMK1(6), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDK1(3), PIK3CA(80), PIK3CD(15), PIK3CG(24), PIK3R1(12), PITX2(5), PPP1R13B(15), PTEN(36), RACGAP1(8), RHO(9), ROCK1(20), ROCK2(16), RPS4X(2), SAG(4), WASF1(8), WASL(5)	41110513	579	192	495	132	159	84	90	96	138	12	1.18e-05	1.000	1.000
281	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(25), BDKRB1(4), BDKRB2(3), C1QA(5), C1QB(1), C1QC(2), C1S(10), C2(2), C3(34), C3AR1(10), C4BPA(5), C4BPB(3), C5(13), C5AR1(6), C6(13), C7(7), C8A(8), C8B(11), C9(8), CD46(3), CD55(3), CFB(8), CFH(27), CFI(14), CPB2(10), CR1(33), CR2(25), F10(8), F11(5), F12(3), F13A1(19), F13B(17), F2(11), F2R(6), F3(2), F5(22), F7(11), F8(29), F9(9), FGA(12), FGB(6), FGG(5), KLKB1(6), KNG1(11), MASP1(3), MASP2(6), MBL2(4), PLAT(7), PLAUR(6), PLG(18), PROC(4), PROS1(11), SERPINA1(7), SERPINA5(8), SERPINC1(5), SERPIND1(5), SERPINE1(3), SERPINF2(8), SERPING1(8), TFPI(5), THBD(2), VWF(38)	53047600	623	191	591	162	157	82	93	139	151	1	0.00212	1.000	1.000
282	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(53), AXIN1(15), CCND1(2), CCND2(2), CCND3(1), CSNK1E(9), CTNNB1(27), DVL1(8), DVL2(10), DVL3(15), FBXW2(2), FOSL1(1), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GSK3B(6), JUN(5), LDLR(12), MAPK10(4), MAPK9(5), MYC(6), PAFAH1B1(15), PPP2R5C(6), PPP2R5E(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RAC1(1), RHOA(20), SFRP4(5), TCF7(9), WNT1(10), WNT10A(6), WNT10B(2), WNT11(3), WNT16(14), WNT2(6), WNT2B(13), WNT3(5), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7)	35204697	533	190	485	156	168	55	54	106	143	7	0.0240	1.000	1.000
283	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(10), CD14(1), CD19(5), CD1A(13), CD1B(7), CD1C(10), CD1D(13), CD1E(11), CD2(4), CD22(5), CD33(9), CD34(4), CD36(5), CD37(2), CD38(5), CD3E(2), CD4(11), CD44(8), CD5(4), CD55(3), CD7(5), CD8A(4), CD8B(2), CD9(1), CR1(33), CR2(25), CSF1(5), CSF1R(17), CSF2RA(10), CSF3(1), CSF3R(13), DNTT(5), EPO(3), EPOR(3), FCER2(4), FCGR1A(4), FLT3(12), FLT3LG(1), GP5(14), GP9(3), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), IL11(3), IL11RA(2), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), IL2RA(2), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL7(2), IL7R(15), IL9R(2), ITGA1(7), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGAM(10), ITGB3(6), KIT(13), KITLG(4), MME(10), MS4A1(2), TFRC(2), THPO(6), TNF(3), TPO(27)	47760133	543	187	504	137	134	68	76	124	139	2	0.000897	1.000	1.000
284	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG1(8), ALG10(14), ALG10B(10), ALG11(8), ALG12(10), ALG13(8), ALG14(2), ALG2(3), ALG3(4), ALG6(4), ALG8(3), ALG9(2), B3GNT1(4), B3GNT2(5), B3GNT6(5), B3GNT7(6), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), B4GALT5(4), B4GALT7(6), C1GALT1(3), C1GALT1C1(6), CHPF(4), CHST1(20), CHST11(4), CHST12(6), CHST13(5), CHST14(2), CHST2(15), CHST3(8), CHST4(7), CHST6(11), CHST7(7), CHSY1(9), DPAGT1(6), EXT1(22), EXT2(7), EXTL1(8), EXTL2(2), EXTL3(12), FUT11(3), FUT8(9), GALNT1(4), GALNT10(8), GALNT11(6), GALNT12(3), GALNT13(9), GALNT14(12), GALNT2(7), GALNT3(4), GALNT4(6), GALNT5(12), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GALNTL5(3), GANAB(19), GCNT1(1), GCNT3(4), GCNT4(4), HS2ST1(3), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), HS3ST5(8), HS6ST1(7), HS6ST2(9), HS6ST3(9), MAN1A1(4), MAN1A2(5), MAN1B1(6), MAN1C1(10), MAN2A1(10), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), MGAT5B(7), NDST1(13), NDST2(13), NDST3(18), NDST4(17), OGT(7), RPN1(4), RPN2(6), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7), ST6GAL1(1), ST6GALNAC1(5), STT3B(5), UST(10), WBSCR17(27), XYLT1(11), XYLT2(43)	64548851	767	182	696	266	250	90	86	146	191	4	0.852	1.000	1.000
285	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2(4), BCR(14), BLNK(5), BTK(4), CD19(5), CD22(5), CD81(6), CR2(25), CSK(8), DAG1(13), FLOT2(9), GRB2(4), GSK3A(4), GSK3B(6), INPP5D(8), ITPR1(34), ITPR2(33), ITPR3(44), LYN(7), MAP4K1(4), MAPK1(3), MAPK3(3), NFATC1(16), NFATC2(26), NR0B2(3), PDK1(3), PIK3CA(80), PIK3CD(15), PIK3R1(12), PLCG2(19), PPP1R13B(15), PPP3CA(13), PPP3CB(6), PPP3CC(6), PTPRC(21), RAF1(9), SHC1(7), SOS1(9), SOS2(18), SYK(9), VAV1(13)	43360160	573	179	498	146	173	88	78	111	119	4	4.78e-05	1.000	1.000
286	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(4), IMPA1(7), IMPA2(2), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPP5B(10), INPP5E(8), INPPL1(27), IPMK(2), ISYNA1(4), ITPK1(6), ITPKA(2), ITPKB(14), MINPP1(6), MIOX(6), OCRL(10), PI4KA(22), PI4KB(10), PIK3C3(16), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PTEN(36), PTPMT1(1), SYNJ1(11), SYNJ2(20)	43509924	571	177	489	122	172	88	83	101	121	6	1.13e-07	1.000	1.000
287	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(10), AKT3(8), BCR(14), BTK(4), CD19(5), CDKN2A(17), DAPP1(1), FLOT2(9), GAB1(4), ITPR1(34), ITPR2(33), ITPR3(44), LYN(7), NR0B2(3), PDK1(3), PHF11(5), PIK3CA(80), PITX2(5), PLCG2(19), PPP1R13B(15), PREX1(21), PTEN(36), PTPRC(21), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SAG(4), SYK(9), TEC(4), VAV1(13)	32336925	464	177	395	118	133	72	63	90	99	7	0.000654	1.000	1.000
288	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(7), BMP4(6), BMP5(11), BMP6(12), BMP7(7), BMP8A(1), BMP8B(3), BTRC(9), CSNK1A1(5), CSNK1A1L(7), CSNK1D(4), CSNK1E(9), CSNK1G1(7), CSNK1G2(7), CSNK1G3(10), DHH(2), FBXW11(9), GAS1(4), GLI1(23), GLI2(18), GLI3(60), GSK3B(6), HHIP(20), IHH(7), LRP2(61), PRKACA(6), PRKACB(6), PRKACG(9), PRKX(6), PTCH1(29), PTCH2(13), RAB23(2), SHH(6), SMO(15), STK36(9), SUFU(6), WNT1(10), WNT10A(6), WNT10B(2), WNT11(3), WNT16(14), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4), ZIC2(7)	35642666	541	173	498	159	190	71	56	94	124	6	0.0210	1.000	1.000
289	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(18), CPEB1(6), EGFR(19), ERBB2(23), ERBB4(59), ETS1(8), ETS2(4), ETV6(9), ETV7(5), FMN2(44), GRB2(4), KRAS(37), MAP2K1(7), MAPK1(3), MAPK3(3), NOTCH1(31), NOTCH2(33), NOTCH3(26), NOTCH4(22), PIWIL1(6), PIWIL2(10), PIWIL3(6), PIWIL4(9), RAF1(9), SOS1(9), SOS2(18), SPIRE1(9), SPIRE2(6)	30573969	443	172	380	112	116	81	48	113	84	1	0.00193	1.000	1.000
290	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(4), AKT1(3), CALM1(2), CALM2(3), CALM3(1), CALR(2), CAMK1(3), CAMK1G(8), CAMK4(10), CREBBP(46), CSNK1A1(5), EDN1(4), ELSPBP1(3), F2(11), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(6), HAND1(5), HAND2(7), HRAS(1), IGF1(2), LIF(4), MAP2K1(7), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), MEF2C(5), MYH2(39), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NKX2-5(7), NPPA(2), PIK3CA(80), PIK3R1(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RAF1(9), RPS6KB1(6), SYT1(5)	29760415	455	172	390	105	140	70	72	77	95	1	1.45e-06	1.000	1.000
291	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(3), AKT2(10), AKT3(8), BRD4(15), CAP1(2), CBL(5), CDC42(3), CDKN2A(17), F2RL2(4), FLOT2(9), GRB2(4), GSK3A(4), GSK3B(6), IGFBP1(11), INPPL1(27), IRS1(27), IRS2(10), IRS4(25), LNPEP(12), MAPK1(3), MAPK3(3), PARD3(17), PDK1(3), PIK3CA(80), PIK3CD(15), PIK3R1(12), PTEN(36), PTPN1(3), RAF1(9), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SERPINB6(4), SFN(1), SHC1(7), SLC2A4(5), SORBS1(12), SOS1(9), SOS2(18), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3)	34898199	490	172	415	112	136	82	61	78	126	7	5.46e-05	1.000	1.000
292	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(10), ACTB(8), ACTG1(1), ARHGEF2(13), ARPC5L(3), CD14(1), CDC42(3), CDH1(33), CLDN1(4), CTNNB1(27), CTTN(12), EZR(5), FYN(9), HCLS1(3), ITGB1(11), KRT18(3), LY96(5), NCK1(6), NCK2(8), NCL(7), OCLN(8), PRKCA(8), RHOA(20), ROCK1(20), ROCK2(16), TLR4(27), TLR5(11), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9), WAS(4), WASL(5), YWHAQ(4), YWHAZ(3)	30824890	392	171	360	102	96	58	50	104	82	2	0.00321	1.000	1.000
293	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(10), ACTB(8), ACTG1(1), ARHGEF2(13), ARPC5L(3), CD14(1), CDC42(3), CDH1(33), CLDN1(4), CTNNB1(27), CTTN(12), EZR(5), FYN(9), HCLS1(3), ITGB1(11), KRT18(3), LY96(5), NCK1(6), NCK2(8), NCL(7), OCLN(8), PRKCA(8), RHOA(20), ROCK1(20), ROCK2(16), TLR4(27), TLR5(11), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9), WAS(4), WASL(5), YWHAQ(4), YWHAZ(3)	30824890	392	171	360	102	96	58	50	104	82	2	0.00321	1.000	1.000
294	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(53), AR(24), ASAH1(4), BRAF(18), CAMP(3), CCL13(1), CCL15(2), CCL16(1), DAG1(13), EGFR(19), GNA11(6), GNA15(4), GNAI1(3), GNAQ(3), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), MAPK10(4), MAPK14(2), PHKA2(15), PIK3CA(80), PIK3CD(15), PIK3R1(12), PITX2(5), PTX3(3), RAF1(9), SRC(5)	31270437	464	170	397	121	129	63	85	90	89	8	0.000617	1.000	1.000
295	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(4), BRAF(18), CHUK(5), CREB1(4), DAXX(11), ELK1(4), FOS(1), GRB2(4), HRAS(1), IKBKB(10), JUN(5), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP2K7(38), MAP3K1(16), MAP3K10(13), MAP3K11(9), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K6(10), MAP3K7(11), MAP3K8(2), MAP3K9(5), MAP4K1(4), MAP4K2(10), MAP4K3(5), MAP4K4(13), MAP4K5(4), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK4(8), MAPK6(3), MAPK7(8), MAPK8(6), MAPK9(5), MAPKAPK2(3), MAPKAPK3(5), MAPKAPK5(4), MAX(3), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MKNK1(5), MKNK2(8), MYC(6), NFKB1(8), NFKBIA(1), PAK1(5), PAK2(12), RAC1(1), RAF1(9), RELA(7), RIPK1(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KA5(5), RPS6KB1(6), RPS6KB2(9), SHC1(7), SP1(5), STAT1(11), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TRADD(2), TRAF2(4)	55598953	582	169	557	153	178	74	64	96	164	6	0.00373	1.000	1.000
296	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(3), APOA1(8), CD36(5), CITED2(4), CPT1B(7), CREBBP(46), DUSP1(3), DUT(3), EHHADH(4), EP300(27), HSD17B4(7), HSPA1A(4), JUN(5), LPL(9), MAPK1(3), MAPK3(3), ME1(1), MYC(6), NCOA1(20), NCOR1(30), NCOR2(40), NFKBIA(1), NR0B2(3), NR1H3(5), NR2F1(11), NRIP1(18), PDGFA(2), PIK3CA(80), PIK3R1(12), PPARA(7), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PTGS2(7), RB1(14), RELA(7), RXRA(13), SP1(5), STAT5A(10), STAT5B(13), TNF(3)	37038167	496	169	436	121	126	78	79	90	118	5	0.000149	1.000	1.000
297	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(40), ASH2L(4), CARM1(8), CTCFL(14), DOT1L(18), EED(7), EHMT1(18), EHMT2(19), EZH1(8), EZH2(5), FBXO11(13), HCFC1(19), HSF4(8), JMJD4(4), JMJD6(3), KDM6A(14), MEN1(11), NSD1(27), OGT(7), PAXIP1(7), PPP1CA(2), PPP1CC(4), PRDM2(38), PRDM7(2), PRDM9(23), PRMT1(3), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), RBBP5(5), SATB1(19), SETD1A(24), SETD2(20), SETD7(3), SETD8(1), SETDB1(17), SETDB2(12), SETMAR(3), SMYD3(3), STK38(6), SUV39H1(6), SUV39H2(2), SUV420H1(18), SUV420H2(6), SUZ12(3), WHSC1(25), WHSC1L1(18)	69604920	539	168	517	139	154	66	73	103	135	8	0.0193	1.000	1.000
298	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ASAH1(4), BRAF(18), CAMP(3), CREB1(4), CREB5(7), CREBBP(46), CRKL(2), DAG1(13), EGR1(12), EGR2(9), EGR3(9), EGR4(7), ELK1(4), FRS2(5), GNAQ(3), JUN(5), MAP1B(25), MAP2K4(9), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), NTRK1(9), OPN1LW(10), PIK3C2G(14), PIK3CA(80), PIK3CD(15), PIK3R1(12), PTPN11(8), RPS6KA3(6), SHC1(7), SRC(5), TERF2IP(5), TH(7)	30050203	449	167	385	109	136	71	70	72	96	4	1.84e-05	1.000	1.000
299	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(40), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADIPOQ(5), ADIPOR1(5), ADIPOR2(6), AGRP(2), AKT1(3), AKT2(10), AKT3(8), CAMKK1(5), CAMKK2(2), CD36(5), CHUK(5), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), G6PC2(1), IKBKB(10), IRS1(27), IRS2(10), IRS4(25), JAK1(19), JAK2(12), JAK3(12), LEP(3), LEPR(14), MAPK10(4), MAPK8(6), MAPK9(5), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NPY(2), PCK1(12), PCK2(10), POMC(9), PPARA(7), PPARGC1A(11), PRKAA1(7), PRKAA2(10), PRKAB1(11), PRKAB2(4), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKCQ(14), PTPN11(8), RELA(7), RXRA(13), RXRB(5), RXRG(7), SLC2A1(8), SLC2A4(5), SOCS3(3), STAT3(7), STK11(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4), TYK2(12)	48560096	556	166	534	161	173	69	57	111	138	8	0.0421	1.000	1.000
300	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(6), DAG1(13), DGKA(9), ETFA(2), GCA(3), ITGA9(9), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), MAP2K1(7), MAPK1(3), MAPK3(3), NR1I3(3), PAK1(5), PDE3A(19), PDE3B(23), PI3(2), PIK3C2G(14), PIK3CA(80), PIK3CD(15), PIK3R1(12), PSME1(3), RIPK3(5), RPS4X(2), SGCB(5), VASP(2)	28496501	379	165	320	98	102	66	69	70	68	4	0.000331	1.000	1.000
301	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(10), AKT3(8), BRAF(18), CAB39(2), EIF4B(5), EIF4EBP1(4), FIGF(5), HIF1A(5), IGF1(2), MAPK1(3), MAPK3(3), PDPK1(1), PGF(3), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PRKAA1(7), PRKAA2(10), RHEB(2), RICTOR(25), RPS6(1), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA6(20), RPS6KB1(6), RPS6KB2(9), STK11(6), TSC1(10), TSC2(14), ULK1(20), ULK2(11), ULK3(2), VEGFB(2), VEGFC(12)	31058180	433	164	365	101	129	64	81	67	88	4	0.000235	1.000	1.000
302	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(3), BDKRB2(3), CALM1(2), CALM2(3), CALM3(1), CAV1(5), CHRM1(6), CHRNA1(7), FLT1(19), FLT4(31), KDR(17), NOS3(15), PDE2A(16), PDE3A(19), PDE3B(23), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKG1(12), PRKG2(15), RYR2(106), SLC7A1(9), SYT1(5), TNNI1(1)	23680532	361	164	340	116	105	45	44	85	81	1	0.189	1.000	1.000
303	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(4), ATP8A1(9), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), CCKAR(7), CCKBR(16), CCR1(7), CCR10(3), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CX3CR1(4), CXCR3(2), CXCR6(2), EDNRA(4), EDNRB(33), FPR1(8), FSHR(24), GALR1(6), GALR2(11), GALR3(4), GALT(3), GHSR(8), GNB2L1(3), GNRHR(5), GRPR(6), LHCGR(18), MC1R(6), MC2R(3), MC3R(11), MC4R(6), MC5R(6), NMBR(3), NPY1R(5), NPY2R(7), NPY5R(4), NTSR1(10), NTSR2(5), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OXTR(8), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), TAC4(3), TACR1(4), TACR2(2), TACR3(15), TRHR(7), TSHR(12)	30722818	462	164	437	165	168	50	75	91	77	1	0.131	1.000	1.000
304	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(9), ADCY6(18), ADCY8(37), CACNA1A(34), CACNA1B(32), GNAS(38), GNAT3(5), GNB1(2), GNB3(2), GNG13(3), GRM4(15), ITPR3(44), KCNB1(16), PDE1A(7), PLCB2(8), PRKACA(6), PRKACB(6), PRKACG(9), PRKX(6), SCNN1A(3), SCNN1B(9), SCNN1G(6), TAS1R1(9), TAS1R2(14), TAS1R3(12), TAS2R1(4), TAS2R10(4), TAS2R13(4), TAS2R14(7), TAS2R16(7), TAS2R3(3), TAS2R38(6), TAS2R39(3), TAS2R4(4), TAS2R40(2), TAS2R41(1), TAS2R42(6), TAS2R43(3), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R60(3), TAS2R7(4), TAS2R8(4), TAS2R9(3), TRPM5(8)	33328508	431	160	413	149	151	54	54	91	80	1	0.340	1.000	1.000
305	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(3), AKT1(3), AKT2(10), AKT3(8), BAD(4), BTK(4), CDKN2A(17), DAPP1(1), GRB2(4), GSK3A(4), GSK3B(6), IARS(11), IGFBP1(11), INPP5D(8), PDK1(3), PIK3CA(80), PPP1R13B(15), PTEN(36), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SOS1(9), SOS2(18), TEC(4), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3)	21127023	318	158	255	72	66	59	49	60	80	4	0.00231	1.000	1.000
306	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(7), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPPL1(27), ITPKA(2), ITPKB(14), MIOX(6), OCRL(10), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3CA(80), PIK3CB(13), PIK3CG(24), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCG1(22), PLCG2(19)	26220818	374	156	307	75	103	67	70	61	71	2	3.03e-06	1.000	1.000
307	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(5), ADAM17(9), ATP6AP1(6), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), CASP3(2), CCL5(3), CDC42(3), CHUK(5), CSK(8), EGFR(19), F11R(2), GIT1(4), HBEGF(2), IGSF5(5), IKBKB(10), JAM2(2), JAM3(6), JUN(5), LYN(7), MAP2K4(9), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK8(6), MAPK9(5), MET(10), NFKB1(8), NFKB2(9), NFKBIA(1), NOD1(13), PAK1(5), PLCG1(22), PLCG2(19), PTPN11(8), PTPRZ1(32), RAC1(1), RELA(7), SRC(5), TCIRG1(6), TJP1(26)	41180324	433	155	412	127	107	65	47	94	117	3	0.137	1.000	1.000
308	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(10), AKT3(8), BAD(4), BCR(14), BLNK(5), BTK(4), CD19(5), CSK(8), DAG1(13), EPHB2(15), GRB2(4), ITPKA(2), ITPKB(14), LYN(7), MAP2K1(7), MAP2K2(3), MAPK1(3), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PI3(2), PIK3CA(80), PIK3CD(15), PIK3R1(12), PLCG2(19), PPP1R13B(15), RAF1(9), SERPINA4(5), SHC1(7), SOS1(9), SOS2(18), SYK(9), VAV1(13)	30894092	387	155	323	96	112	62	58	76	77	2	0.000713	1.000	1.000
309	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(5), APC(53), ATF2(4), AXIN1(15), BMP10(6), BMP2(7), BMP4(6), BMP5(11), BMP7(7), BMPR1A(12), BMPR2(21), CHRD(10), CTNNB1(27), DVL1(8), FZD1(11), GATA4(4), GSK3B(6), MAP3K7(11), MEF2C(5), MYL2(9), NKX2-5(7), NOG(2), NPPA(2), NPPB(3), RFC1(14), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), TGFBR3(9), WNT1(10)	21326728	331	154	307	82	78	31	40	59	116	7	0.0488	1.000	1.000
310	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(14), AMY2A(7), AMY2B(18), ENPP1(7), ENPP3(12), GAA(8), GANAB(19), GBE1(7), GCK(9), GPI(6), GUSB(10), GYS1(8), GYS2(9), HK1(17), HK2(12), HK3(11), MGAM(19), PGM1(3), PGM3(13), PYGB(14), PYGL(11), PYGM(14), RNPC3(1), SI(35), UCHL1(3), UCHL3(4), UGDH(8), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5), UXS1(8)	33290788	357	154	335	108	89	42	48	90	87	1	0.207	1.000	1.000
311	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(5), CDC40(8), CLK2(15), CLK3(13), CLK4(5), COL2A1(18), CPSF1(28), CPSF2(7), CPSF3(3), CPSF4(2), CSTF1(10), CSTF2(5), CSTF2T(12), CSTF3(9), DDIT3(5), DDX1(11), DDX20(3), DHX15(13), DHX16(9), DHX38(14), DHX8(18), DHX9(13), DICER1(10), DNAJC8(5), FUS(2), GIPC1(6), METTL3(2), NCBP1(7), NCBP2(3), NONO(5), NUDT21(3), NXF1(5), PABPN1(4), PAPOLA(7), PHF5A(1), POLR2A(24), PPM1G(4), PRPF18(2), PRPF3(8), PRPF4(7), PRPF4B(13), PRPF8(18), PSKH1(7), PTBP1(10), PTBP2(4), RBM17(2), RBM5(9), RNGTT(4), RNMT(9), RNPS1(1), SF3A1(6), SF3A2(2), SF3A3(2), SF3B1(13), SF3B2(16), SF3B4(9), SNRPA(7), SNRPA1(5), SNRPB(2), SNRPB2(2), SNRPD1(2), SNRPD2(5), SNRPD3(4), SNRPE(2), SNRPG(1), SNRPN(10), SPOP(4), SRPK1(8), SRPK2(8), SRRM1(17), SUPT5H(16), U2AF1(5), U2AF2(15), XRN2(15)	62004493	584	153	561	130	182	72	88	86	154	2	0.000598	1.000	1.000
312	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(10), AKT3(8), ANKRD6(9), APC(53), AXIN1(15), AXIN2(20), CER1(3), CSNK1A1(5), CTNNB1(27), DACT1(10), DKK1(12), DKK2(8), DKK3(4), DKK4(5), DVL1(8), FSTL1(3), GSK3A(4), GSK3B(6), LRP1(54), MVP(11), NKD1(8), NKD2(2), PIN1(2), PSEN1(5), PTPRA(15), SENP2(7), SFRP1(7), TSHB(3), WIF1(3)	23600918	330	153	305	89	95	35	45	62	85	8	0.0713	1.000	1.000
313	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(8), ARHGDIB(1), BAG4(5), BCL2(4), BID(2), BIRC2(7), BIRC3(10), CASP2(3), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CFLAR(1), CHUK(5), CRADD(6), DAXX(11), DFFA(4), DFFB(3), FADD(3), GSN(12), LMNA(11), LMNB1(4), LMNB2(6), MAP2K7(38), MAP3K1(16), MAP3K5(10), MAPK8(6), MDM2(8), NFKB1(8), NFKBIA(1), NUMA1(26), PAK2(12), PRKCD(10), PRKDC(56), PSEN1(5), PSEN2(3), PTK2(11), RASA1(19), RB1(14), RELA(7), RIPK1(3), SPTAN1(22), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(4), TRAF2(4)	40491706	432	148	413	115	122	53	65	67	119	6	0.0334	1.000	1.000
314	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(4), AK3(5), CAD(20), CANT1(5), CTPS2(3), DCK(4), DCTD(1), DHODH(4), DPYD(20), DPYS(8), DUT(3), ENTPD1(4), ENTPD3(6), ENTPD4(13), ENTPD5(2), ENTPD6(6), ENTPD8(7), ITPA(1), NME2(3), NME4(2), NME6(3), NME7(1), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT2(5), PNPT1(5), POLA1(8), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(7), RFC5(2), RRM1(5), RRM2(3), RRM2B(4), TK1(1), TK2(4), TXNRD1(10), TXNRD2(4), TYMS(1), UCK1(6), UCK2(1), UMPS(5), UPB1(6), UPP1(2), UPP2(7), UPRT(6), ZNRD1(2)	47451760	456	145	441	130	146	52	64	85	109	0	0.0225	1.000	1.000
315	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(9), APH1A(1), CREBBP(46), CTBP1(5), CTBP2(8), DLL1(16), DLL3(9), DLL4(5), DTX1(18), DTX2(6), DTX3(7), DTX3L(2), DTX4(12), DVL1(8), DVL2(10), DVL3(15), EP300(27), HDAC1(9), HDAC2(6), HES1(1), JAG1(16), JAG2(17), LFNG(2), MAML1(6), MAML2(12), MAML3(9), MFNG(1), NCOR2(40), NCSTN(12), NOTCH1(31), NOTCH2(33), NOTCH3(26), NOTCH4(22), NUMB(3), NUMBL(5), PSEN1(5), PSEN2(3), PSENEN(2), PTCRA(2), RBPJ(7), RBPJL(9), RFNG(3), SNW1(7)	40371949	493	145	472	169	167	63	63	78	119	3	0.216	1.000	1.000
316	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), AOX1(14), CARM1(8), COMT(5), DBH(7), DCT(16), DDC(12), ECH1(5), ESCO1(10), ESCO2(10), FAH(7), GOT1(3), GOT2(2), GSTZ1(2), HEMK1(1), HGD(6), HPD(4), LCMT1(1), LCMT2(11), MAOA(4), MAOB(3), METTL6(5), MIF(1), NAT6(4), PNMT(11), PNPLA3(4), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SH3GLB1(3), TAT(5), TH(7), TPO(27), TYR(15), TYRP1(9), WBSCR22(5)	34823559	353	140	324	84	89	34	40	76	110	4	0.0177	1.000	1.000
317	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(10), AKT3(8), ASAH1(4), BRAF(18), DAG1(13), DRD2(10), EGFR(19), EPHB2(15), GRB2(4), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), PI3(2), PIK3CB(13), PITX2(5), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), RAF1(9), RGS20(7), SHC1(7), SOS1(9), SOS2(18), SRC(5), STAT3(7), TERF2IP(5)	34279235	412	139	390	134	138	54	51	82	83	4	0.245	1.000	1.000
318	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(19), GABBR1(18), GPRC5A(1), GPRC5B(14), GPRC5C(9), GPRC5D(2), GRM1(43), GRM2(27), GRM3(22), GRM4(15), GRM5(37), GRM7(27), GRM8(27)	12307253	261	138	251	83	102	27	34	60	38	0	0.0587	1.000	1.000
319	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(5), CD28(1), CSK(8), CTLA4(4), DAG1(13), EPHB2(15), FBXW7(32), GRAP2(5), GRB2(4), ITK(5), ITPKA(2), ITPKB(14), LAT(3), LCK(4), LCP2(10), MAPK1(3), NCK1(6), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PLCG1(22), PTPRC(21), RAF1(9), RASGRP1(7), RASGRP2(8), RASGRP3(6), RASGRP4(6), SOS1(9), SOS2(18), VAV1(13), ZAP70(13)	32696127	363	138	338	102	125	38	40	71	87	2	0.0620	1.000	1.000
320	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AGK(6), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), AKR1A1(3), AKR1B1(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CEL(16), DAK(7), DGAT1(10), DGAT2(2), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), GK(4), GK2(9), GLA(3), GLB1(7), GPAM(11), LCT(24), LIPA(3), LIPC(5), LIPF(7), LIPG(4), LPL(9), MGLL(2), PNLIP(6), PNLIPRP1(3), PNPLA3(4), PPAP2A(3), PPAP2B(2), PPAP2C(6)	34304628	356	137	336	101	98	40	49	70	97	2	0.0764	1.000	1.000
321	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), ASCC3(37), ATP13A2(16), DDX18(14), DDX19A(5), DDX23(12), DDX4(9), DDX41(9), DDX47(1), DDX50(12), DDX51(7), DDX52(7), DDX54(17), DDX55(5), DDX56(8), DHX58(11), ENTPD7(10), EP400(47), ERCC2(9), ERCC3(8), FPGS(7), GCH1(1), GGH(2), IFIH1(10), MOV10L1(9), NUDT5(1), NUDT8(1), QDPR(5), RAD54B(3), RAD54L(4), RUVBL2(9), SETX(24), SKIV2L2(13), SMARCA2(31), SMARCA5(10), SPR(2)	36810663	409	136	396	122	135	45	52	80	95	2	0.150	1.000	1.000
322	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(4), CDK5(3), CDK5R1(5), CFL1(1), CHN1(4), LIMK1(6), MAP3K1(16), MYL2(9), MYLK(25), NCF2(3), PAK1(5), PDGFRA(13), PIK3CA(80), PIK3R1(12), PLD1(22), PPP1R12B(16), RAC1(1), RALBP1(10), RPS6KB1(6), TRIO(47), VAV1(13), WASF1(8)	20487306	309	136	255	68	76	58	50	62	60	3	0.000241	1.000	1.000
323	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(9), AKT1(3), APC(53), ASAH1(4), CAMP(3), CAV3(2), DAG1(13), DLG4(4), EPHB2(15), GNAI1(3), GNAQ(3), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), PITX2(5), PTX3(3), RAC1(1), RHO(9), RYR1(68)	26855057	339	136	327	111	121	35	43	64	69	7	0.120	1.000	1.000
324	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(16), AR(24), ESR1(8), ESR2(9), ESRRA(2), HNF4A(7), NPM1(1), NR0B1(5), NR1D1(9), NR1D2(8), NR1H2(7), NR1H3(5), NR1I2(9), NR1I3(3), NR2C2(6), NR2E1(4), NR2F1(11), NR2F2(5), NR2F6(5), NR3C1(9), NR4A1(5), NR4A2(15), NR5A1(9), NR5A2(4), PGR(18), PPARA(7), PPARD(8), PPARG(4), RARA(4), RARB(10), RARG(2), ROR1(11), RORA(7), RORC(7), RXRA(13), RXRB(5), RXRG(7), THRA(7), THRB(4), VDR(4)	24589043	304	135	294	109	109	41	35	68	50	1	0.418	1.000	1.000
325	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(10), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(6), CDC42(3), CFL1(1), CFL2(1), FLNA(28), FLNC(38), FSCN1(6), FSCN3(13), GDI1(5), GDI2(6), LIMK1(6), MYH2(39), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PFN1(1), PFN2(1), RHO(9), ROCK1(20), ROCK2(16), RPS4X(2), VASP(2), WASF1(8), WASL(5)	28057152	319	135	313	109	114	37	44	54	66	4	0.230	1.000	1.000
326	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), AVP(4), CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), HDAC5(13), IGF1(2), IGF1R(20), INSR(17), MAP2K6(1), MAPK14(2), MAPK7(8), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MYOD1(7), NFATC1(16), NFATC2(26), PIK3CA(80), PIK3R1(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), SYT1(5), YWHAH(3)	20358100	302	134	249	85	87	54	60	45	54	2	0.00164	1.000	1.000
327	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(16), ACSS2(12), ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH7A1(2), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), G6PC2(1), GALM(4), GAPDH(3), GAPDHS(5), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKL(8), PFKM(2), PFKP(21), PGAM1(1), PGAM2(5), PGAM4(2), PGK1(4), PGK2(3), PGM1(3), PGM3(13), PKLR(9), TPI1(3)	34076688	369	134	348	117	97	66	46	79	81	0	0.116	1.000	1.000
328	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(3), ACADM(7), ACOX1(3), ACOX2(8), ACOX3(13), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADIPOQ(5), ANGPTL4(3), APOA1(8), APOA5(7), AQP7(8), CD36(5), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), CYP27A1(6), CYP4A11(4), CYP4A22(5), CYP7A1(7), CYP8B1(6), DBI(1), EHHADH(4), FABP2(1), FABP3(1), FABP4(1), FABP5(2), FABP6(4), FABP7(1), FADS2(4), GK(4), GK2(9), HMGCS2(4), ILK(9), LPL(9), ME1(1), MMP1(3), NR1H3(5), OLR1(4), PCK1(12), PCK2(10), PDPK1(1), PLTP(5), PPARA(7), PPARD(8), PPARG(4), RXRA(13), RXRB(5), RXRG(7), SCD(1), SCP2(5), SLC27A1(4), SLC27A2(8), SLC27A4(10), SLC27A5(5), SLC27A6(11), SORBS1(12), UBC(9), UCP1(4)	38366394	380	134	371	122	129	45	50	80	76	0	0.221	1.000	1.000
329	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2(4), GRB2(4), GSK3A(4), GSK3B(6), IL4R(7), IRS1(27), IRS2(10), JAK1(19), JAK3(12), MAP4K1(4), MAPK1(3), MAPK3(3), PDK1(3), PIK3CA(80), PIK3CD(15), PIK3R1(12), PPP1R13B(15), RAF1(9), SHC1(7), SOCS1(1), SOS1(9), SOS2(18), STAT6(7)	21432466	304	134	240	60	79	57	48	43	73	4	3.73e-05	1.000	1.000
330	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(21), AKT1(3), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CREB1(4), GNAS(38), GRB2(4), HRAS(1), MAPK1(3), MAPK14(2), MAPK3(3), PIK3CA(80), PIK3R1(12), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), RAC1(1), RPS6KA1(9), RPS6KA5(5), SOS1(9)	17108683	264	133	211	57	78	50	46	41	46	3	0.000217	1.000	1.000
331	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(15), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), CDIPT(1), CDS1(5), CDS2(3), CHAT(6), CHKA(2), CHKB(3), CHPT1(4), CRLS1(1), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), ESCO1(10), ESCO2(10), ETNK1(3), ETNK2(2), GNPAT(4), GPAM(11), GPD1(8), GPD1L(4), GPD2(8), LCAT(4), LYPLA1(1), LYPLA2(2), NAT6(4), PCYT1A(9), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(5), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLD1(22), PLD2(19), PNPLA3(4), PPAP2A(3), PPAP2B(2), PPAP2C(6), PTDSS1(6), PTDSS2(3), SH3GLB1(3)	38300543	355	133	338	98	111	32	49	74	87	2	0.0422	1.000	1.000
332	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(9), GRB2(4), HRAS(1), INSR(17), IRS1(27), JAK2(12), MAP2K1(7), MAPK1(3), MAPK3(3), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), PTPN6(6), RAF1(9), RPS6KA1(9), SHC1(7), SLC2A4(5), SOCS1(1), SOS1(9), SRF(5), STAT5A(10), STAT5B(13)	19411108	281	132	227	56	70	61	50	41	55	4	3.99e-06	1.000	1.000
333	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(49), BMPR1B(9), CCND2(2), CDK4(2), CDKN1B(1), DMC1(8), EGR1(12), ESR2(9), FSHR(24), GJA4(8), INHA(6), LHCGR(18), MLH1(8), MSH5(5), NCOR1(30), NR5A1(9), NRIP1(18), PGR(18), PRLR(5), PTGER2(7), SMPD1(6), VDR(4), ZP2(12)	20542440	270	132	255	58	64	39	38	58	67	4	0.00157	1.000	1.000
334	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(28), ACACB(40), ACAT1(6), ACAT2(5), ACOT12(7), ACSS1(16), ACSS2(12), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), DLAT(8), DLD(10), GLO1(2), GRHPR(2), HAGH(5), HAGHL(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), LDHD(2), MDH1(3), ME1(1), ME2(7), ME3(7), PC(18), PCK1(12), PCK2(10), PDHA1(1), PDHA2(11), PDHB(4), PKLR(9)	27388341	315	130	296	100	86	51	37	59	81	1	0.327	1.000	1.000
335	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), F10(8), F11(5), F12(3), F2(11), F2R(6), F5(22), F8(29), F9(9), FGA(12), FGB(6), FGG(5), KLKB1(6), PROC(4), PROS1(11), SERPINC1(5), SERPING1(8)	26059769	265	130	260	78	61	45	32	70	55	2	0.113	1.000	1.000
336	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(14), ATP4A(20), ATP4B(4), ATP5A1(3), ATP5B(9), ATP5C1(5), ATP5F1(3), ATP5G2(2), ATP5G3(2), ATP5J(3), ATP5J2(1), ATP5L(1), ATP6AP1(6), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), COX10(2), COX15(5), COX4I1(4), COX4I2(3), COX5B(1), COX6B1(2), COX7A1(1), COX7B(3), COX7C(1), COX8A(1), COX8C(4), CYC1(5), LHPP(3), NDUFA1(1), NDUFA10(3), NDUFA12(2), NDUFA13(2), NDUFA3(1), NDUFA8(6), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(1), NDUFB11(2), NDUFB2(1), NDUFB3(3), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFB8(2), NDUFB9(2), NDUFC2(2), NDUFS1(7), NDUFS2(6), NDUFS3(3), NDUFS4(3), NDUFS5(3), NDUFS6(4), NDUFS7(4), NDUFS8(2), NDUFV1(6), NDUFV2(1), PPA1(4), PPA2(3), SDHA(11), SDHB(4), SDHC(2), SDHD(1), TCIRG1(6), UQCRB(2), UQCRC1(3), UQCRC2(5), UQCRFS1(3), UQCRQ(1)	32635977	359	129	340	102	103	56	44	64	91	1	0.0450	1.000	1.000
337	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(7), ACTN2(26), BCAR1(10), BCR(14), CAPN1(7), CAPNS1(3), CAPNS2(2), CAV1(5), CRKL(2), CSK(8), FYN(9), GRB2(4), HRAS(1), ITGA1(7), ITGB1(11), JUN(5), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MAPK8(6), PPP1R12B(16), PTK2(11), PXN(6), RAF1(9), RAP1A(3), ROCK1(20), SHC1(7), SOS1(9), SRC(5), TLN1(28), VCL(11), ZYX(7)	27571226	279	129	268	80	109	29	30	57	52	2	0.0267	1.000	1.000
338	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(4), CHUK(5), DAXX(11), EGF(11), EGFR(19), ETS1(8), ETS2(4), FOS(1), HOXA7(4), HRAS(1), IKBKB(10), JUN(5), MAP2K1(7), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP2K7(38), MAP3K1(16), MAP3K5(10), MAPK1(3), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), NFKB1(8), NFKBIA(1), PPP2CA(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), RAF1(9), RELA(7), RIPK1(3), SP1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRAF2(4)	28766217	316	129	304	92	111	41	32	56	72	4	0.0139	1.000	1.000
339	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(5), CAD(20), CANT1(5), CTPS2(3), DCK(4), DCTD(1), DHODH(4), DPYD(20), DPYS(8), DUT(3), ENTPD1(4), ITPA(1), NME2(3), NT5E(5), NT5M(6), NUDT2(5), POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14), RRM1(5), RRM2(3), TK1(1), TK2(4), TXNRD1(10), TYMS(1), UCK1(6), UCK2(1), UMPS(5), UNG(2), UPB1(6), UPP1(2)	33571699	328	129	318	104	90	45	49	61	83	0	0.237	1.000	1.000
340	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(13), EEF1A2(7), EEF1B2(4), EEF1D(3), EEF1G(4), EEF2(17), EEF2K(11), EIF1AX(2), EIF1AY(1), EIF2AK1(5), EIF2AK2(6), EIF2AK3(21), EIF2B1(4), EIF2B2(4), EIF2B3(9), EIF2B4(11), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(4), EIF4EBP2(4), EIF4G1(25), EIF4G3(22), EIF5(6), EIF5A(5), EIF5B(28), ETF1(7), GSPT2(9), PABPC1(10), PABPC3(15), PAIP1(3), SLC35A4(9)	25609736	295	129	279	60	73	41	45	61	72	3	0.000497	1.000	1.000
341	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BAD(4), BCL2(4), BCL2L1(1), CBL(5), CFLAR(1), CRKL(2), E2F1(4), FOS(1), GRB2(4), HRAS(1), IL2RA(2), IL2RB(3), IL2RG(9), IRS1(27), JAK1(19), JAK3(12), MAPK1(3), MAPK3(3), MYC(6), NMI(2), PIK3CA(80), PIK3R1(12), PTPN6(6), RAF1(9), RPS6KB1(6), SHC1(7), SOCS1(1), SOCS3(3), SOS1(9), STAT5A(10), STAT5B(13), SYK(9)	21165573	281	128	223	59	59	57	52	44	65	4	0.000236	1.000	1.000
342	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(15), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPS(6), CDIPT(1), CDS1(5), CDS2(3), CHAT(6), CHKA(2), CHKB(3), CLC(2), CPT1B(7), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), ETNK1(3), GNPAT(4), GPD1(8), GPD2(8), LCAT(4), LYPLA1(1), LYPLA2(2), PAFAH1B1(15), PAFAH2(4), PCYT1A(9), PCYT1B(6), PEMT(1), PISD(5), PLA2G1B(8), PLA2G2A(2), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB2(8), PLCG1(22), PLCG2(19), PPAP2A(3), PPAP2B(2), PPAP2C(6)	29176602	306	126	285	87	100	26	47	65	66	2	0.0750	1.000	1.000
343	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(8), AASDHPPT(1), AASS(10), ACAT1(6), ACAT2(5), AKR1B10(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), BBOX1(4), DLST(6), DOT1L(18), ECHS1(2), EHHADH(4), EHMT1(18), EHMT2(19), GCDH(7), HADH(2), HADHA(5), HSD17B4(7), HSD3B7(7), NSD1(27), OGDH(11), OGDHL(19), PIPOX(3), PLOD1(9), PLOD2(15), PLOD3(17), RDH11(1), RDH12(3), RDH13(7), SETD1A(24), SETD7(3), SETDB1(17), SHMT1(2), SHMT2(11), SPCS1(2), SPCS3(3), SUV39H1(6), SUV39H2(2), TMLHE(5)	33949841	379	126	350	107	117	44	51	65	101	1	0.0646	1.000	1.000
344	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(48), B3GALT4(8), CDR1(4), DGKI(16), IL6ST(6), PIGK(3), RPL10(5), RPL11(1), RPL12(3), RPL13A(4), RPL14(2), RPL15(1), RPL17(1), RPL18(1), RPL18A(1), RPL19(1), RPL22(9), RPL23(1), RPL24(2), RPL26(1), RPL27(1), RPL28(1), RPL29(2), RPL3(3), RPL31(2), RPL34(1), RPL35A(1), RPL36(1), RPL37(1), RPL38(1), RPL3L(3), RPL4(3), RPL5(3), RPL6(3), RPL7A(6), RPL8(3), RPL9(4), RPLP0(4), RPLP1(1), RPLP2(2), RPS10(1), RPS11(1), RPS13(2), RPS14(1), RPS15(2), RPS16(1), RPS18(1), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(1), RPS26(1), RPS27(1), RPS27A(4), RPS3(2), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA6(20), RPS6KB1(6), RPS6KB2(9), RPS7(1), RPS9(2), RPSA(5), SLC36A2(5), TBC1D10C(9), TSPAN9(3), UBA52(2), UBB(2), UBC(9)	30681489	298	126	283	93	80	32	46	61	77	2	0.709	1.000	1.000
345	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(3), AGXT2(13), AKR1B10(6), ALAS1(5), ALAS2(14), AMT(4), AOC2(10), AOC3(13), BHMT(5), CBS(9), CHDH(6), CHKA(2), CHKB(3), CTH(3), DAO(14), DLD(10), DMGDH(7), GAMT(1), GARS(3), GATM(3), GCAT(5), GLDC(9), GNMT(4), HSD3B7(7), MAOA(4), MAOB(3), PEMT(1), PHGDH(5), PIPOX(3), PISD(5), PSAT1(7), PSPH(2), RDH11(1), RDH12(3), RDH13(7), SARDH(12), SARS(9), SARS2(9), SDS(4), SHMT1(2), SHMT2(11), TARS(11), TARS2(13)	24954298	271	125	261	83	84	36	38	47	65	1	0.174	1.000	1.000
346	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(8), AANAT(2), ACAT1(6), ACAT2(5), ACMSD(6), AFMID(4), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AOC2(10), AOC3(13), AOX1(14), ASMT(5), CARM1(8), CAT(6), CYP1A1(7), CYP1A2(5), CYP1B1(4), DDC(12), ECHS1(2), EHHADH(4), GCDH(7), HAAO(1), HADH(2), HADHA(5), HEMK1(1), HSD17B4(7), INMT(4), KMO(6), KYNU(13), LCMT1(1), LCMT2(11), LNX1(5), MAOA(4), MAOB(3), METTL6(5), NFX1(5), OGDH(11), OGDHL(19), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), TDO2(9), TPH1(4), TPH2(10), WARS(4), WARS2(12), WBSCR22(5)	35456223	372	124	338	101	82	49	48	64	126	3	0.103	1.000	1.000
347	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(8), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BCL2L2(4), BOK(2), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CD40(3), CD40LG(5), CRADD(6), DAXX(11), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), IKBKE(12), LTA(4), MCL1(2), NFKB1(8), NFKBIA(1), NGFR(7), NR3C1(9), NTRK1(9), PTPN13(34), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(4), TRAF2(4), TRAF3(7), TRAF6(6)	25424180	240	123	230	71	61	30	30	56	62	1	0.196	1.000	1.000
348	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(5), B3GALNT1(5), B3GALT1(3), B3GALT2(8), B3GALT4(8), B3GALT5(2), B3GNT1(4), B3GNT2(5), B3GNT3(3), B3GNT4(9), B3GNT5(11), B4GALNT1(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), B4GALT6(6), FUT1(5), FUT2(2), FUT3(4), FUT4(2), FUT5(3), FUT6(6), FUT7(3), FUT9(7), GBGT1(4), GCNT2(1), PIGA(3), PIGB(10), PIGC(6), PIGG(15), PIGK(3), PIGL(5), PIGM(4), PIGN(6), PIGO(10), PIGP(1), PIGQ(9), PIGS(4), PIGT(11), PIGV(7), PIGX(3), PIGZ(10), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7), ST3GAL5(2), ST3GAL6(6), ST6GALNAC3(6), ST6GALNAC4(3), ST6GALNAC5(9), ST6GALNAC6(4), ST8SIA1(12), ST8SIA5(8), UGCG(3)	28384348	312	123	290	109	100	32	33	61	85	1	0.784	1.000	1.000
349	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRA2A(9), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), HRH1(5), HRH2(6), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14)	15089408	276	122	263	100	110	28	43	63	32	0	0.142	1.000	1.000
350	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(10), AKT3(8), ARHGEF11(25), BCL2(4), CDC42(3), DLG4(4), GNA13(7), LPA(21), MAP2K4(9), MAP3K1(16), MAP3K5(10), MAPK8(6), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(15), PI3(2), PIK3CB(13), PLD1(22), PLD2(19), PLD3(8), PTK2(11), RDX(7), ROCK1(20), ROCK2(16), SERPINA4(5), SRF(5), TBXA2R(9)	28780249	313	122	296	68	84	43	39	45	97	5	0.00156	1.000	1.000
351	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AKR1A1(3), AKR1B1(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), CEL(16), DGAT1(10), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), GK(4), GLA(3), GLB1(7), LCT(24), LIPC(5), LIPF(7), LIPG(4), LPL(9), PNLIP(6), PNLIPRP1(3), PPAP2A(3), PPAP2B(2), PPAP2C(6)	28172803	296	121	277	92	83	28	42	57	84	2	0.324	1.000	1.000
352	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(9), ALOX15(10), ALOX5(11), CBR1(1), CBR3(4), CYP4F2(13), CYP4F3(13), EPX(16), GGT1(9), LPO(11), LTA4H(4), MPO(9), PLA2G1B(8), PLA2G2A(2), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PRDX1(1), PRDX2(2), PRDX6(2), PTGDS(1), PTGES2(4), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7), TPO(27)	16306513	225	121	211	59	85	20	20	61	36	3	0.0187	1.000	1.000
353	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(5), CASP2(3), CASP3(2), CASP8(18), CRADD(6), DFFA(4), DFFB(3), FADD(3), JUN(5), LMNA(11), LMNB1(4), LMNB2(6), MADD(18), MAP2K4(9), MAP3K1(16), MAP3K7(11), MAPK8(6), PAK1(5), PAK2(12), PRKDC(56), RB1(14), RIPK1(3), SPTAN1(22), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4)	22708199	258	121	249	71	64	29	44	38	80	3	0.187	1.000	1.000
354	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), AOX1(14), COMT(5), DBH(7), DCT(16), DDC(12), FAH(7), GOT1(3), GOT2(2), GSTZ1(2), HGD(6), HPD(4), MAOA(4), MAOB(3), PNMT(11), TAT(5), TH(7), TPO(27), TYR(15)	18556486	232	121	210	60	63	20	26	53	67	3	0.0825	1.000	1.000
355	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(16), CARM1(8), CCND1(2), CREBBP(46), EP300(27), ERCC3(8), ESR1(8), GRIP1(20), GTF2A1(3), GTF2E1(6), GTF2F1(6), HDAC1(9), HDAC2(6), HDAC3(7), HDAC4(29), HDAC5(13), HDAC6(9), MEF2C(5), NCOR2(40), NR0B1(5), NRIP1(18), PELP1(8), POLR2A(24), TBP(6)	26880867	329	120	313	81	108	46	40	54	77	4	0.00120	1.000	1.000
356	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKM(2), PFKP(21), PGAM1(1), PGK1(4), PGM1(3), PGM3(13), PKLR(9), TPI1(3)	28639423	312	120	293	100	79	49	40	72	72	0	0.254	1.000	1.000
357	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKM(2), PFKP(21), PGAM1(1), PGK1(4), PGM1(3), PGM3(13), PKLR(9), TPI1(3)	28639423	312	120	293	100	79	49	40	72	72	0	0.254	1.000	1.000
358	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(21), CALM1(2), CALM2(3), CALM3(1), CREB1(4), ELK1(4), FOS(1), GNAI1(3), GNAQ(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), JUN(5), MAP2K1(7), MAPK3(3), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), RAF1(9), RPS6KA3(6), SYT1(5)	20525662	278	120	262	69	111	34	27	44	61	1	0.00150	1.000	1.000
359	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(9), APC(53), AXIN1(15), BTRC(9), CTNNB1(27), DLL1(16), DVL1(8), FZD1(11), GSK3B(6), NOTCH1(31), PSEN1(5), WNT1(10)	12510776	200	120	179	60	49	18	17	36	75	5	0.378	1.000	1.000
360	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(21), AKT1(3), BAD(4), BAX(1), BCL2(4), BCL2L1(1), CSF2RB(12), IGF1(2), IGF1R(20), IL3(1), IL3RA(5), KIT(13), KITLG(4), PIK3CA(80), PIK3R1(12), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), YWHAH(3)	12867021	225	119	176	66	53	50	48	36	36	2	0.0143	1.000	1.000
361	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CFLAR(1), DAXX(11), DFFA(4), DFFB(3), FADD(3), FAF1(10), JUN(5), LMNA(11), LMNB1(4), LMNB2(6), MAP2K4(9), MAP3K1(16), MAP3K7(11), MAPK8(6), PAK1(5), PAK2(12), PRKDC(56), PTPN13(34), RB1(14), RIPK2(2), SPTAN1(22)	23814795	279	119	265	71	59	32	50	45	91	2	0.0984	1.000	1.000
362	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1C1(3), AKR1C2(1), AKR1C3(3), AKR1C4(5), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), CYP1A1(7), CYP1A2(5), CYP1B1(4), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2F1(9), CYP2S1(8), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), DHDH(5), EPHX1(10), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), MGST1(3), MGST2(3), MGST3(3), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7)	33511006	296	119	279	79	68	34	42	68	84	0	0.105	1.000	1.000
363	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT1(6), ACAT2(5), ACMSD(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), AOC2(10), AOC3(13), AOX1(14), ASMT(5), CAT(6), CYP19A1(12), CYP1A1(7), CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2D6(13), CYP2E1(6), CYP2F1(9), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(4), CYP4B1(11), CYP51A1(9), DDC(12), ECHS1(2), EHHADH(4), GCDH(7), HAAO(1), HADHA(5), KMO(6), KYNU(13), MAOA(4), MAOB(3), SDS(4), TDO2(9), TPH1(4), WARS(4), WARS2(12)	32277886	359	119	330	94	94	45	38	67	113	2	0.0665	1.000	1.000
364	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), ELK1(4), FPR1(8), GNA15(4), GNB1(2), GNGT1(3), HRAS(1), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), NCF1(3), NCF2(3), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKBIA(1), PAK1(5), PIK3C2G(14), PLCB1(21), PPP3CA(13), PPP3CB(6), PPP3CC(6), RAC1(1), RAF1(9), RELA(7), SYT1(5)	22388699	250	118	237	74	80	32	31	43	64	0	0.0779	1.000	1.000
365	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(3), AGXT2(13), ALAS1(5), ALAS2(14), AMT(4), AOC2(10), AOC3(13), ATP6V0C(1), BHMT(5), CBS(9), CHDH(6), CHKA(2), CHKB(3), CPT1B(7), CTH(3), DAO(14), DLD(10), DMGDH(7), GAMT(1), GARS(3), GATM(3), GCAT(5), GLDC(9), MAOA(4), MAOB(3), PEMT(1), PISD(5), PLCB2(8), PLCG1(22), PLCG2(19), PSPH(2), SARDH(12), SARS(9), SHMT1(2), SHMT2(11), TARS(11)	24548785	259	118	249	78	78	33	33	50	65	0	0.165	1.000	1.000
366	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(4), ARSD(5), ARSE(6), CARM1(8), CYP11B1(17), CYP11B2(8), CYP19A1(12), HEMK1(1), HSD11B1(4), HSD11B2(4), HSD17B1(4), HSD17B12(4), HSD17B2(3), HSD17B3(2), HSD17B7(5), HSD3B1(4), HSD3B2(2), LCMT1(1), LCMT2(11), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), SULT2B1(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), WBSCR22(5)	29329371	273	118	260	85	55	50	39	58	70	1	0.214	1.000	1.000
367	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(7), AARS2(15), ABAT(4), ACY3(3), ADSL(5), ADSS(6), ADSSL1(9), AGXT(3), AGXT2(13), ASL(5), ASNS(5), ASPA(2), ASRGL1(4), ASS1(10), CAD(20), CRAT(12), DARS(2), DARS2(4), DDO(6), DLAT(8), DLD(10), GAD1(8), GAD2(15), GOT1(3), GOT2(2), GPT(4), GPT2(3), NARS(5), NARS2(3), PC(18), PDHA1(1), PDHA2(11), PDHB(4)	22152893	230	117	220	80	74	32	28	41	54	1	0.495	1.000	1.000
368	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(7), AARS2(15), CARS(6), CARS2(7), DARS(2), DARS2(4), EARS2(3), EPRS(18), FARS2(9), FARSA(6), FARSB(3), GARS(3), HARS(9), HARS2(4), IARS(11), IARS2(12), KARS(7), LARS(9), LARS2(10), MARS(7), MARS2(5), MTFMT(2), NARS(5), NARS2(3), QARS(7), RARS(5), RARS2(6), SARS(9), SARS2(9), TARS(11), TARS2(13), VARS(23), VARS2(14), WARS(4), WARS2(12), YARS(8), YARS2(2)	31823951	290	117	282	79	86	36	48	54	65	1	0.0921	1.000	1.000
369	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(10), ADCY3(18), ADCY9(17), AK1(1), ARF1(5), ARF4(1), ARF6(1), ARL4D(1), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), ERO1L(2), GNAS(38), PDIA4(6), PLCG1(22), PLCG2(19), PRKCA(8), SEC61A1(4), SEC61A2(4), SEC61B(1), SEC61G(1), TRIM23(9)	21715043	267	117	254	69	101	33	32	48	53	0	0.00852	1.000	1.000
370	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(8), ARHGAP4(4), ARHGAP5(26), ARHGAP6(12), ARHGEF1(12), ARHGEF11(25), ARHGEF5(7), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), BAIAP2(5), CFL1(1), DIAPH1(14), GSN(12), LIMK1(6), MYL2(9), MYLK(25), OPHN1(10), PFN1(1), PIP5K1A(3), PIP5K1B(2), PPP1R12B(16), ROCK1(20), SRC(5), TLN1(28), VCL(11)	26569801	277	116	264	70	89	38	32	45	67	6	0.0234	1.000	1.000
371	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(5), BTK(4), CALM1(2), CALM2(3), CALM3(1), CD79A(8), CD79B(3), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP2K1(7), MAP3K1(16), MAPK14(2), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SYK(9), SYT1(5), VAV1(13)	22434798	253	115	237	58	93	35	25	42	58	0	0.000548	1.000	1.000
372	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(4), CALM1(2), CALM2(3), CALM3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CDK5(3), F2(11), FYN(9), GNA11(6), GNAI1(3), GNB1(2), GNGT1(3), GRB2(4), HRAS(1), JAK2(12), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), MAPT(11), MYLK(25), PLCG1(22), PRKCA(8), PTK2B(16), RAF1(9), SHC1(7), SOS1(9), STAT1(11), STAT3(7), STAT5A(10), SYT1(5)	24410931	254	115	246	74	85	37	26	56	48	2	0.0501	1.000	1.000
373	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(8), F11(5), F12(3), F13B(17), F2(11), F5(22), F7(11), F8(29), F9(9), FGA(12), FGB(6), FGG(5), LPA(21), PLAT(7), PLG(18), SERPINB2(9), SERPINE1(3), SERPINF2(8), VWF(38)	20687247	242	115	236	62	61	28	33	66	53	1	0.0449	1.000	1.000
374	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(3), ACAA2(9), ACADM(7), ACADS(4), ACAT1(6), ACAT2(5), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH7A1(2), ALDH9A1(6), AOX1(14), AUH(7), BCAT1(6), BCAT2(9), BCKDHA(12), BCKDHB(3), DBT(4), DLD(10), ECHS1(2), EHHADH(4), HADH(2), HADHA(5), HADHB(6), HIBADH(3), HIBCH(2), HMGCS1(2), HMGCS2(4), HSD17B4(7), IVD(4), MCCC1(4), MCCC2(7), MCEE(5), MUT(7), OXCT1(10), OXCT2(6), PCCA(12), PCCB(5)	25210128	263	115	242	67	60	41	33	42	86	1	0.0504	1.000	1.000
375	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(4), GTF2B(3), GTF2E1(6), GTF2E2(4), GTF2F1(6), GTF2F2(3), GTF2H1(5), GTF2H3(3), GTF2H4(9), GTF2I(4), GTF2IRD1(13), STON1(7), TAF1(27), TAF10(1), TAF13(1), TAF1L(37), TAF2(10), TAF4(14), TAF4B(7), TAF5(2), TAF5L(7), TAF6(14), TAF6L(7), TAF7(7), TAF7L(8), TAF9B(4), TBPL1(3), TBPL2(5)	21129651	224	115	214	56	55	31	28	47	63	0	0.0797	1.000	1.000
376	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(11), AKT1(3), AKT2(10), AKT3(8), DAG1(13), GNAQ(3), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(15), PIK3CB(13), PITX2(5), PLD1(22), PLD2(19), PLD3(8), VN1R1(4)	26265937	296	113	285	81	102	32	43	58	57	4	0.0289	1.000	1.000
377	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH4A1(4), ALDH9A1(6), AMD1(7), AOC2(10), AOC3(13), ARG1(2), ARG2(3), ASL(5), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), DAO(14), GAMT(1), GATM(3), GLUD1(4), GOT1(3), GOT2(2), MAOA(4), MAOB(3), NOS1(39), NOS3(15), OAT(3), ODC1(3), OTC(4), P4HA1(5), P4HA2(8), P4HA3(6), P4HB(3), PYCR1(3), RARS(5), SMS(6)	25849437	291	111	270	82	84	30	44	57	76	0	0.136	1.000	1.000
378	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(9), ALDOC(7), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GAPDHS(5), GCK(9), GOT1(3), GOT2(2), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHAL6B(6), LDHB(5), LDHC(1), MDH1(3), PC(18), PCK1(12), PDHA1(1), PDHA2(11), PDHB(4), PDHX(5), PFKL(8), PFKM(2), PFKP(21), PGAM1(1), PGAM2(5), PGK1(4), PGK2(3), PKLR(9), TNFAIP1(5), TPI1(3)	24880392	257	111	247	103	85	52	23	49	48	0	0.659	1.000	1.000
379	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(8), ALG10(14), ALG10B(10), ALG11(8), ALG12(10), ALG13(8), ALG14(2), ALG2(3), ALG3(4), ALG5(4), ALG6(4), ALG8(3), ALG9(2), B4GALT1(3), B4GALT2(8), B4GALT3(2), DHDDS(2), DOLPP1(3), DPAGT1(6), DPM1(2), FUT8(9), GANAB(19), MAN1A1(4), MAN1A2(5), MAN1B1(6), MAN1C1(10), MAN2A1(10), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), MGAT5B(7), RFT1(4), RPN1(4), RPN2(6), ST6GAL1(1), STT3B(5)	24778247	233	111	214	70	49	30	23	49	80	2	0.579	1.000	1.000
380	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(10), AADAC(6), ABAT(4), ACADS(4), ACAT1(6), ACAT2(5), ACSM1(7), AKR1B10(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH5A1(5), ALDH7A1(2), ALDH9A1(6), BDH1(7), DDHD1(13), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADH(2), HADHA(5), HMGCS1(2), HMGCS2(4), HSD17B4(7), HSD3B7(7), ILVBL(8), L2HGDH(2), OXCT1(10), OXCT2(6), PDHA1(1), PDHA2(11), PDHB(4), PLA1A(3), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(7)	23741398	245	111	228	83	72	33	29	43	68	0	0.425	1.000	1.000
381	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(9), ALOX12B(12), ALOX15(10), ALOX15B(4), ALOX5(11), CBR1(1), CBR3(4), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2J2(4), CYP2U1(9), CYP4A11(4), CYP4A22(5), CYP4F2(13), CYP4F3(13), DHRS4(4), EPHX2(3), GGT1(9), GPX5(2), GPX7(3), LTA4H(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PTGDS(1), PTGES(1), PTGES2(4), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7)	22770913	243	110	232	66	88	25	25	60	43	2	0.0223	1.000	1.000
382	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(8), CALCR(6), CALCRL(10), CD97(8), CRHR1(12), CRHR2(4), ELTD1(22), EMR1(11), EMR2(10), GHRHR(4), GIPR(6), GLP1R(1), GLP2R(10), GPR64(14), LPHN1(22), LPHN2(23), LPHN3(23), SCTR(5), VIPR1(3), VIPR2(5)	15573293	207	109	202	49	52	32	23	64	36	0	0.00274	1.000	1.000
383	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(20), CPS1(24), EARS2(3), EPRS(18), GAD1(8), GAD2(15), GCLC(3), GCLM(3), GFPT1(7), GFPT2(6), GLS(11), GLS2(8), GLUD1(4), GLUD2(13), GLUL(5), GMPS(7), GNPNAT1(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), GSR(5), GSS(2), NADSYN1(11), PPAT(7), QARS(7)	23154336	218	109	212	76	58	28	32	50	50	0	0.508	1.000	1.000
384	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(5), ALAS2(14), BLVRA(4), BLVRB(1), COX10(2), COX15(5), CP(10), CPOX(4), EARS2(3), EPRS(18), FECH(7), FTH1(3), FTMT(8), GUSB(10), HCCS(4), HMBS(3), HMOX1(7), HMOX2(1), MMAB(2), PPOX(6), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), UROD(2), UROS(5)	24626477	223	109	214	69	44	35	31	54	59	0	0.419	1.000	1.000
385	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(18), ADRBK2(5), ARRB2(2), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CLCA1(10), CLCA2(8), CLCA4(18), CNGA3(9), CNGA4(19), CNGB1(19), GNAL(3), GUCA1A(2), GUCA1B(1), GUCA1C(3), PDC(3), PDE1C(14), PRKACA(6), PRKACB(6), PRKACG(9), PRKG1(12), PRKG2(15), PRKX(6)	17888812	217	109	203	63	62	23	26	49	57	0	0.142	1.000	1.000
386	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3E(2), CD4(11), CREBBP(46), CSK(8), GNAS(38), GNB1(2), GNGT1(3), HLA-DRA(7), HLA-DRB1(1), LCK(4), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTPRC(21), ZAP70(13)	13504037	216	108	199	77	80	21	23	39	52	1	0.689	1.000	1.000
387	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3E(2), CD4(11), CREBBP(46), CSK(8), GNAS(38), GNB1(2), GNGT1(3), HLA-DRA(7), HLA-DRB1(1), LCK(4), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTPRC(21), ZAP70(13)	13504037	216	108	199	77	80	21	23	39	52	1	0.689	1.000	1.000
388	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(19), ELK1(4), GNAS(38), GNB1(2), GNGT1(3), GRB2(4), HRAS(1), IGF1R(20), ITGB1(11), KLK2(1), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MKNK1(5), MKNK2(8), MYC(6), NGFR(7), PDGFRA(13), PPP2CA(4), PTPRR(10), RAF1(9), RPS6KA1(9), RPS6KA5(5), SHC1(7), SOS1(9), SRC(5), STAT3(7)	19421324	223	108	209	86	86	28	20	55	33	1	0.716	1.000	1.000
389	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACAA2(9), ACADL(3), ACADM(7), ACADS(4), ACADSB(8), ACADVL(3), ACAT1(6), ACAT2(5), ACOX1(3), ACOX3(13), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), CYP4A11(4), CYP4A22(5), ECHS1(2), EHHADH(4), GCDH(7), HADH(2), HADHA(5), HADHB(6), HSD17B4(7)	28695790	263	106	245	61	61	41	39	43	79	0	0.00310	1.000	1.000
390	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(28), ACAT1(6), ACAT2(5), ACYP1(1), ACYP2(3), ADH5(4), AKR1B1(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), DLAT(8), DLD(10), GLO1(2), GRHPR(2), HAGH(5), HAGHL(2), LDHA(7), LDHB(5), LDHC(1), LDHD(2), MDH1(3), ME1(1), ME2(7), ME3(7), PC(18), PCK1(12), PDHA1(1), PDHA2(11), PDHB(4), PKLR(9)	21636561	237	106	221	84	63	36	31	42	65	0	0.716	1.000	1.000
391	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(8), CDC7(7), CDK2(4), CDT1(5), DIAPH2(10), GMNN(2), MCM10(13), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), NACA(19), PCNA(2), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), PRIM1(2), RFC1(14), RFC2(3), RFC3(4), RFC4(1), RFC5(2), RPA1(3), RPA2(4), RPA3(1), RPA4(6), RPS27A(4), UBA52(2), UBB(2), UBC(9)	29739675	257	105	247	64	83	30	28	42	74	0	0.0488	1.000	1.000
392	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(2), ARG2(3), ASL(5), ASS1(10), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), DAO(14), EPRS(18), GAMT(1), GATM(3), GLUD1(4), GLUD2(13), GOT1(3), GOT2(2), LAP3(4), NOS1(39), NOS3(15), OAT(3), OTC(4), P4HA1(5), P4HA2(8), P4HA3(6), PRODH(1), PYCR1(3), PYCR2(4), PYCRL(2), RARS(5), RARS2(6)	20996436	229	105	217	72	70	27	34	49	49	0	0.303	1.000	1.000
393	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(8), AASDH(10), AASDHPPT(1), AASS(10), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), ATP6V0C(1), BBOX1(4), DLST(6), DOT1L(18), ECHS1(2), EHHADH(4), EHMT1(18), EHMT2(19), GCDH(7), HADHA(5), PLOD1(9), PLOD2(15), PLOD3(17), SDS(4), SHMT1(2), SHMT2(11), TMLHE(5)	21645601	254	105	230	70	65	32	37	39	80	1	0.0650	1.000	1.000
394	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), DAG1(13), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), NFAT5(13), PDE6A(9), PDE6B(14), PDE6C(5), PDE6D(1), PDE6G(1), PDE6H(1), SLC6A13(8), TF(15)	20936097	229	105	222	82	84	27	33	41	41	3	0.296	1.000	1.000
395	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(5), ELK1(4), FOS(1), IKBKB(10), IRAK1(7), JUN(5), LY96(5), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP3K7(11), MAPK14(2), MAPK8(6), MYD88(4), NFKB1(8), NFKBIA(1), PPARA(7), RELA(7), TIRAP(1), TLR10(9), TLR2(4), TLR3(6), TLR4(27), TLR6(4), TLR7(6), TLR9(15), TOLLIP(6), TRAF6(6)	21361429	205	105	197	56	48	29	24	47	56	1	0.0574	1.000	1.000
396	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(1), ATF2(4), CALM1(2), CALM2(3), CALM3(1), EGFR(19), ELK1(4), GNAQ(3), GRB2(4), HRAS(1), JUN(5), MAP2K1(7), MAP2K2(3), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), PAK1(5), PRKCA(8), PTK2(11), PTK2B(16), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SRC(5), SYT1(5)	19637730	195	104	184	56	58	19	23	35	59	1	0.128	1.000	1.000
397	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(28), ACACB(40), ACADM(7), ACAT1(6), ACAT2(5), ACSS1(16), ACSS2(12), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH7A1(2), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), HIBCH(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), MCEE(5), MLYCD(8), MUT(7), PCCA(12), PCCB(5), SUCLA2(3), SUCLG1(2), SUCLG2(8)	23267028	264	104	243	56	64	42	31	52	74	1	0.00275	1.000	1.000
398	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(8), ARSB(2), FUCA1(1), FUCA2(2), GALNS(3), GBA(12), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), HGSNAT(5), HPSE(11), HPSE2(10), HYAL1(7), HYAL2(8), IDS(4), IDUA(4), LCT(24), MAN2B1(19), MAN2B2(19), MAN2C1(11), MANBA(10), NAGLU(8), NEU1(3), NEU2(7), NEU3(5), NEU4(3), SPAM1(10)	20139847	226	104	221	58	69	37	38	33	49	0	0.0125	1.000	1.000
399	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(14), ATP4B(4), ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), ATP7A(16), ATP7B(15), COX10(2), COX4I1(4), COX5B(1), COX6B1(2), COX7A1(1), COX7B(3), COX7C(1), COX8A(1), NDUFA1(1), NDUFA10(3), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(6), NDUFV1(6), NDUFV2(1), PPA2(3), SDHA(11), SDHB(4), SHMT1(2), UQCRB(2), UQCRC1(3), UQCRFS1(3)	22369586	245	104	229	69	70	33	36	42	62	2	0.115	1.000	1.000
400	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(4), BRAF(18), CREB1(4), CREB5(7), DUSP4(2), DUSP6(4), DUSP9(8), EEF2K(11), EIF4E(2), GRB2(4), MAP2K1(7), MAP2K2(3), MAP3K8(2), MAPK1(3), MAPK3(3), MKNK1(5), MKNK2(8), MOS(11), NFKB1(8), RAP1A(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), SHC1(7), SOS1(9), SOS2(18), TRAF3(7)	17285756	185	102	172	64	52	27	13	42	51	0	0.672	1.000	1.000
401	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(3), CALM3(1), CHUK(5), EGR2(9), EGR3(9), GNAQ(3), MAP3K1(16), MYC(6), NFATC1(16), NFATC2(26), NFKB1(8), NFKBIA(1), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RELA(7), SYT1(5), VIP(7), VIPR2(5)	16402640	215	102	202	57	75	28	17	38	57	0	0.0189	1.000	1.000
402	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(3), B4GALT2(8), FBP2(6), GAA(8), GALE(1), GALK1(4), GALK2(3), GALT(3), GANAB(19), GCK(9), GLA(3), GLB1(7), HK1(17), HK2(12), HK3(11), LALBA(1), LCT(24), MGAM(19), PFKM(2), PFKP(21), PGM1(3), PGM3(13)	19015189	203	101	185	77	73	26	21	42	41	0	0.694	1.000	1.000
403	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), FPGT(7), FUK(7), GMDS(1), GMPPA(7), GMPPB(6), HK1(17), HK2(12), HK3(11), HSD3B7(7), KHK(2), LHPP(3), MPI(3), MTMR1(7), MTMR2(9), MTMR6(9), PFKFB1(6), PFKFB2(5), PFKFB3(8), PFKFB4(5), PFKL(8), PFKM(2), PFKP(21), PGM2(1), PHPT1(2), PMM1(3), PMM2(2), RDH11(1), RDH12(3), RDH13(7), SORD(3), TPI1(3), TSTA3(9)	21716824	236	101	229	75	85	39	30	29	53	0	0.0704	1.000	1.000
404	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(6), B4GALT1(3), B4GALT2(8), G6PC2(1), GAA(8), GALE(1), GALK1(4), GALK2(3), GALT(3), GANC(9), GCK(9), GLA(3), GLB1(7), HK1(17), HK2(12), HK3(11), HSD3B7(7), LALBA(1), LCT(24), MGAM(19), PFKL(8), PFKM(2), PFKP(21), PGM1(3), PGM3(13), RDH11(1), RDH12(3), RDH13(7), UGP2(9)	22544622	229	101	215	91	87	29	26	42	45	0	0.810	1.000	1.000
405	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(16), DYRK1B(15), GLI2(18), GLI3(60), GSK3B(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), SHH(6), SMO(15), SUFU(6)	9753396	181	101	173	70	66	24	13	39	37	2	0.450	1.000	1.000
406	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(20), CPS1(24), EPRS(18), GAD1(8), GAD2(15), GCLC(3), GCLM(3), GFPT1(7), GLS(11), GLS2(8), GLUD1(4), GLUL(5), GMPS(7), GOT1(3), GOT2(2), GPT(4), GPT2(3), GSS(2), NADSYN1(11), PPAT(7), QARS(7)	19463962	185	100	181	61	48	26	28	39	44	0	0.408	1.000	1.000
407	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(3), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH7A1(2), ALDH9A1(6), AMDHD1(1), AOC2(10), AOC3(13), ASPA(2), CARM1(8), CNDP1(5), DDC(12), FTCD(7), HAL(4), HARS(9), HARS2(4), HDC(11), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(11), MAOA(4), MAOB(3), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), PRPS1(3), PRPS2(3), UROC1(12), WBSCR22(5)	23170694	247	100	226	56	56	26	35	47	81	2	0.0225	1.000	1.000
408	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(7), CAPN2(10), CAPNS1(3), CAPNS2(2), CXCR3(2), EGF(11), EGFR(19), HRAS(1), ITGA1(7), ITGB1(11), MAPK1(3), MAPK3(3), MYL2(9), MYLK(25), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTK2(11), PXN(6), TLN1(28)	19153213	201	100	192	67	73	30	18	34	45	1	0.227	1.000	1.000
409	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(4), CDC42(3), CREB1(4), DAXX(11), DDIT3(5), ELK1(4), GRB2(4), HMGN1(2), HRAS(1), HSPB1(2), HSPB2(1), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP3K5(10), MAP3K7(11), MAP3K9(5), MAPK14(2), MAPKAPK2(3), MAPKAPK5(4), MAX(3), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MKNK1(5), MYC(6), PLA2G4A(7), RAC1(1), RIPK1(3), RPS6KA5(5), SHC1(7), STAT1(11), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TRADD(2), TRAF2(4)	21478710	206	100	198	54	53	30	26	33	61	3	0.0560	1.000	1.000
410	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(4), BCR(14), BLNK(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP2K1(7), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8IP3(12), PAPPA(29), RAC1(1), RPS6KA1(9), RPS6KA3(6), SHC1(7), SOS1(9), SYK(9), VAV1(13), VAV2(13), VAV3(14)	18753018	196	100	188	67	60	27	22	44	43	0	0.347	1.000	1.000
411	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(9), AZIN1(4), CBX3(4), CLDN5(4), CLOCK(8), CRY1(3), CRY2(7), DAZAP2(4), DNAJA1(9), ETV6(9), G0S2(3), GFRA1(10), GSTM3(2), GSTP1(1), HERPUD1(2), HSPA8(5), IDI1(2), KLF9(3), MYF6(4), NCKAP1(13), NCOA4(7), NR1D2(8), PER1(6), PER2(15), PPP1R3C(4), PPP2CB(4), PSMA4(4), PURA(2), SF3A3(2), SUMO3(7), TOB1(1), TUBB3(10), UCP3(4), UGP2(9), VAPA(3), ZFR(16)	21427966	208	99	199	63	57	18	28	41	63	1	0.485	1.000	1.000
412	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(17), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC4(2), ANAPC5(5), ANAPC7(6), BTRC(9), CDC16(7), CDC20(7), CDC23(6), CDC26(2), CDC27(5), CUL1(24), CUL2(9), CUL3(8), FBXW11(9), FBXW7(32), FZR1(8), ITCH(4), RBX1(1), SKP2(6), SMURF1(7), SMURF2(5), TCEB1(1), UBA1(4), UBE2C(1), UBE2D3(1), UBE2E1(2), UBE2E2(1), UBE2E3(3), VHL(2), WWP1(13), WWP2(15)	23536448	232	99	209	43	74	29	29	32	67	1	0.000109	1.000	1.000
413	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(10), CALM1(2), CALM2(3), CALM3(1), CRKL(2), GNAQ(3), GRB2(4), HRAS(1), JUN(5), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), PAK1(5), PLCG1(22), PRKCA(8), PTK2B(16), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SRC(5), SYT1(5)	16689733	178	99	168	43	63	18	19	30	47	1	0.0174	1.000	1.000
414	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), DDC(12), EPX(16), ESCO1(10), ESCO2(10), GOT1(3), GOT2(2), HPD(4), LPO(11), MAOA(4), MAOB(3), MIF(1), MPO(9), NAT6(4), PNPLA3(4), PRDX6(2), SH3GLB1(3), TAT(5), TPO(27)	20038770	187	98	171	42	50	16	16	44	59	2	0.105	1.000	1.000
415	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(8), POLA2(4), POLB(6), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLG(10), POLG2(5), POLH(7), POLI(3), POLK(10), POLL(4), POLM(13), POLQ(37), PRIM1(2), PRIM2(7), REV1(9), REV3L(50), RFC5(2)	23776885	246	98	236	68	60	37	29	37	79	4	0.335	1.000	1.000
416	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(3), CALM3(1), DLG4(4), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), NOS1(39), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), SYT1(5)	14963506	203	98	194	65	70	26	22	39	46	0	0.131	1.000	1.000
417	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(6), ANXA2(3), ANXA3(1), ANXA4(6), ANXA5(4), ANXA6(3), CYP11A1(6), EDN1(4), EDNRA(4), EDNRB(33), HPGD(3), HSD11B1(4), HSD11B2(4), PLA2G4A(7), PRL(1), PTGDR(8), PTGDS(1), PTGER2(7), PTGER4(12), PTGFR(5), PTGIS(8), PTGS1(13), PTGS2(7), S100A6(1), SCGB1A1(3), TBXAS1(7)	12108188	161	98	149	49	39	13	25	42	41	1	0.425	1.000	1.000
418	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(17), BAIAP2(5), CASP1(3), CASP3(2), CASP7(4), CASP8(18), GAPDH(3), INSR(17), ITCH(4), MAGI1(26), MAGI2(28), RERE(30), WWP1(13), WWP2(15)	14068619	185	97	176	48	43	23	24	32	61	2	0.157	1.000	1.000
419	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(21), CAP1(2), CCNB1(3), CDC25C(11), GNAI1(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), MAPK1(3), MAPK3(3), MYT1(22), PIN1(2), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RPS6KA1(9), SRC(5)	12084317	171	97	162	54	64	22	12	36	35	2	0.304	1.000	1.000
420	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(5), CREBBP(46), DUSP1(3), EP300(27), IKBKB(10), IL1B(4), MAP2K3(11), MAP2K6(1), MAP3K7(11), MAPK11(1), MAPK14(2), MYD88(4), NFKB1(8), NFKBIA(1), NR3C1(9), RELA(7), TGFBR1(8), TGFBR2(17), TLR2(4), TNF(3)	17360728	182	97	175	48	44	21	27	35	55	0	0.0929	1.000	1.000
421	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ACADL(3), ACADM(7), ACADSB(8), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), AOC2(10), AOC3(13), CNDP1(5), DPYD(20), DPYS(8), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), MLYCD(8), SDS(4), SMS(6), UPB1(6)	17035869	203	96	189	49	44	25	28	44	62	0	0.0219	1.000	1.000
422	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(22), EXT2(7), EXTL1(8), EXTL2(2), EXTL3(12), GLCE(6), HS2ST1(3), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), HS3ST5(8), HS6ST1(7), HS6ST2(9), HS6ST3(9), NDST1(13), NDST2(13), NDST3(18), NDST4(17)	12130671	180	96	170	61	59	27	19	49	25	1	0.488	1.000	1.000
423	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(4), DLG4(4), EPHB2(15), F2(11), F2RL1(1), F2RL2(4), F2RL3(4), JUN(5), MAP2K5(1), MAPK1(3), MAPK7(8), MAPK8(6), MYEF2(8), PLD1(22), PLD2(19), PLD3(8), PTK2(11), RAF1(9), RASAL1(11), SRC(5), TEC(4), VAV1(13)	16061421	176	96	174	48	58	24	19	32	43	0	0.0884	1.000	1.000
424	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACAA2(9), ACADL(3), ACADM(7), ACADS(4), ACADSB(8), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH9A1(6), AOX1(14), BCAT1(6), BCKDHA(12), BCKDHB(3), ECHS1(2), EHHADH(4), HADHA(5), HADHB(6), HIBADH(3), IVD(4), MCCC1(4), MCCC2(7), MCEE(5), MUT(7), OXCT1(10), PCCA(12), PCCB(5), SDS(4)	21103575	231	96	212	60	45	39	32	38	76	1	0.0999	1.000	1.000
425	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(7), ACTN2(26), BCAR1(10), CSK(8), CTNNA1(17), CTNNA2(24), CTNNB1(27), PTK2(11), PXN(6), SRC(5), VCL(11)	11204907	152	95	142	53	54	10	20	36	29	3	0.592	1.000	1.000
426	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(9), ACP2(5), ACP5(3), ACPP(5), ACPT(6), ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), CYP19A1(12), CYP1A1(7), CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2D6(13), CYP2E1(6), CYP2F1(9), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(4), CYP4B1(11), CYP51A1(9), PON1(3)	17197789	199	95	189	65	80	22	19	34	44	0	0.246	1.000	1.000
427	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(4), ARSD(5), ARSE(6), ASAH1(4), B4GALT6(6), CERK(7), DEGS1(1), DEGS2(2), ENPP7(4), GAL3ST1(12), GALC(5), GBA(12), GLA(3), GLB1(7), LCT(24), NEU1(3), NEU2(7), NEU3(5), NEU4(3), PPAP2A(3), PPAP2B(2), PPAP2C(6), SGMS1(4), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(6), SMPD2(3), SMPD3(10), SMPD4(12), SPHK1(10), SPHK2(8), SPTLC1(5), SPTLC2(4), UGCG(3), UGT8(6)	20903003	211	95	204	74	70	29	31	37	44	0	0.407	1.000	1.000
428	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(7), ACTN2(26), CAPN1(7), CAPNS1(3), CAPNS2(2), ITGA1(7), ITGB1(11), ITGB3(6), PTK2(11), PXN(6), RAC1(1), SPTAN1(22), SRC(5), TLN1(28)	16715768	146	95	140	53	69	15	13	27	22	0	0.453	1.000	1.000
429	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(5), CSNK1D(4), DRD1(4), DRD2(10), GRM1(43), PLCB1(21), PPP1CA(2), PPP1R1B(3), PPP2CA(4), PPP3CA(13), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	9390687	151	94	145	39	44	20	18	34	35	0	0.0343	1.000	1.000
430	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(8), BCL2(4), BID(2), BIRC2(7), BIRC3(10), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CFLAR(1), CHUK(5), DFFA(4), DFFB(3), FADD(3), GAS2(2), LMNA(11), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), SPTAN1(22), TNFRSF10A(2), TNFRSF10B(2), TNFRSF25(5), TNFSF10(9), TRADD(2), TRAF2(4)	19570967	161	94	153	40	37	27	12	37	47	1	0.152	1.000	1.000
431	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(8), GTF2A1(3), GTF2B(3), GTF2E1(6), GTF2F1(6), HDAC3(7), NCOA1(20), NCOA2(27), NCOA3(15), NCOR2(40), POLR2A(24), RARA(4), RXRA(13), TBP(6)	14567533	182	94	179	66	57	35	23	31	33	3	0.519	1.000	1.000
432	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAA2(9), ACAD8(5), ACAD9(8), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1B10(6), AKR1C4(5), AKR1D1(4), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), BAAT(6), CEL(16), CYP27A1(6), CYP7A1(7), HADHB(6), HSD3B7(7), LIPA(3), RDH11(1), RDH12(3), RDH13(7), SLC27A5(5), SOAT1(11), SOAT2(3), SRD5A1(2)	18514509	209	93	194	53	48	32	39	36	54	0	0.0310	1.000	1.000
433	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ACADM(7), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AOC2(10), AOC3(13), CNDP1(5), DPYD(20), DPYS(8), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), HIBCH(2), MLYCD(8), SMS(6), SRM(1), UPB1(6)	15819734	181	93	167	40	40	21	24	38	58	0	0.0105	1.000	1.000
434	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(4), CHIT1(5), CMAS(6), CTBS(3), CYB5R1(3), CYB5R3(4), GFPT1(7), GFPT2(6), GNE(11), GNPDA1(4), GNPDA2(7), GNPNAT1(6), HEXA(2), HEXB(3), HK1(17), HK2(12), HK3(11), LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), NANS(6), NPL(4), PGM3(13), PHPT1(2), RENBP(3), UAP1(5)	16801825	177	93	170	47	47	29	24	41	36	0	0.0260	1.000	1.000
435	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(5), EGF(11), EGFR(19), GRB2(4), HRAS(1), MAP2K1(7), MAPK1(3), MAPK3(3), PTPRB(26), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SPRY1(2), SPRY3(8), SPRY4(6), SRC(5)	14639398	144	93	138	44	38	20	12	40	33	1	0.446	1.000	1.000
436	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), ERCC3(8), GTF2B(3), GTF2E1(6), GTF2E2(4), GTF2F2(3), GTF2H1(5), GTF2H4(9), ILK(9), MNAT1(3), POLR1A(19), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3B(11), POLR3D(5), POLR3E(6), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(14), TAF7(7), TBP(6)	20533691	185	92	182	64	57	19	27	31	51	0	0.629	1.000	1.000
437	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), P4HB(3), SLC23A1(7), SLC23A2(10), SLC2A1(8), SLC2A3(10)	14684253	153	92	147	54	45	28	17	29	32	2	0.278	1.000	1.000
438	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(21), GNAS(38), GNB1(2), GNGT1(3), PPP2CA(4), PRKAA1(7), PRKAA2(10), PRKAB1(11), PRKAB2(4), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	9024175	151	90	142	37	57	15	12	24	41	2	0.143	1.000	1.000
439	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), CDC42(3), CREB1(4), CREB5(7), DUSP1(3), DUSP10(8), EEF2K(11), EIF4E(2), ELK1(4), HSPB1(2), IL1R1(4), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K10(13), MAP3K4(26), MAP3K5(10), MAP3K7(11), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPKAPK2(3), MAPKAPK5(4), MKNK1(5), MKNK2(8), MYEF2(8), NFKB1(8), NR2C2(6), SRF(5), TRAF6(6)	19513196	196	90	191	54	45	40	25	35	50	1	0.0311	1.000	1.000
440	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(11), AGT(4), AGTR1(1), AGTR2(4), CMA1(2), COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), REN(7)	14801470	144	89	141	48	35	30	16	29	32	2	0.314	1.000	1.000
441	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(15), CHAT(6), COMT(5), DBH(7), DDC(12), GAD1(8), GAD2(15), HDC(11), MAOA(4), PAH(6), PNMT(11), SLC18A3(16), TH(7), TPH1(4)	8421070	129	89	123	46	44	15	11	26	32	1	0.428	1.000	1.000
442	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(5), B4GALT5(4), C1GALT1(3), C1GALT1C1(6), GALNT1(4), GALNT10(8), GALNT11(6), GALNT12(3), GALNT13(9), GALNT14(12), GALNT2(7), GALNT3(4), GALNT4(6), GALNT5(12), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GALNTL5(3), GCNT1(1), GCNT3(4), GCNT4(4), OGT(7), ST3GAL1(5), ST3GAL2(9), ST6GALNAC1(5), WBSCR17(27)	18955878	173	89	169	66	60	21	21	33	37	1	0.902	1.000	1.000
443	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), AGPS(6), CHPT1(4), ENPP2(11), ENPP6(7), PAFAH1B1(15), PAFAH1B2(1), PAFAH1B3(2), PAFAH2(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLD1(22), PLD2(19), PPAP2A(3), PPAP2B(2), PPAP2C(6)	13582604	172	89	160	39	46	20	31	42	33	0	0.0123	1.000	1.000
444	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), DDC(12), EPX(16), GOT1(3), GOT2(2), HPD(4), LPO(11), MAOA(4), MAOB(3), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), TAT(5), TPO(27)	12842204	158	89	143	42	45	14	16	38	43	2	0.239	1.000	1.000
445	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(11), ACO1(7), ACO2(11), CLYBL(3), CS(1), DLD(10), DLST(6), FH(4), IDH1(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), OGDH(11), OGDHL(19), PC(18), PCK1(12), PCK2(10), SDHA(11), SDHB(4), SDHC(2), SDHD(1), SUCLA2(3), SUCLG1(2), SUCLG2(8)	17518974	173	88	164	57	59	26	19	24	45	0	0.372	1.000	1.000
446	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAPN2(10), CAPNS1(3), CAPNS2(2), EP300(27), HDAC1(9), HDAC2(6), MEF2D(8), NFATC1(16), NFATC2(26), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), SYT1(5)	14300668	171	88	161	44	61	20	21	28	41	0	0.0121	1.000	1.000
447	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(28), ACADL(3), ACADM(7), ACADSB(8), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), LDHA(7), LDHB(5), LDHC(1), MCEE(5), MLYCD(8), MUT(7), PCCA(12), PCCB(5), SDS(4), SUCLA2(3), SUCLG1(2), SUCLG2(8)	19421267	212	88	194	50	48	35	28	40	61	0	0.0392	1.000	1.000
448	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(41), MAP2(40), PPP1CA(2), PPP2CA(4), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAR2A(3), PRKAR2B(9), PRKCE(14)	10666615	133	87	126	44	23	13	22	43	30	2	0.756	1.000	1.000
449	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(10), ABAT(4), ACADS(4), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH5A1(5), ALDH9A1(6), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), L2HGDH(2), OXCT1(10), PDHA1(1), PDHA2(11), PDHB(4), SDHB(4), SDS(4)	15106691	171	87	159	62	42	22	21	33	53	0	0.684	1.000	1.000
450	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(5), IFNA1(1), IFNB1(3), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1RAP(6), IL1RN(1), IRAK1(7), IRAK2(11), IRAK3(9), JUN(5), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAP3K7(11), MAPK14(2), MAPK8(6), MYD88(4), NFKB1(8), NFKBIA(1), RELA(7), TGFB1(3), TGFB2(9), TGFB3(9), TNF(3), TOLLIP(6), TRAF6(6)	17372497	171	87	164	44	39	26	16	34	55	1	0.0997	1.000	1.000
451	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(34), C5(13), C6(13), C7(7), ICAM1(4), IL1A(2), ITGA4(16), ITGAL(22), ITGB1(11), ITGB2(12), SELP(11), SELPLG(9), TNF(3), VCAM1(9)	14536352	166	87	156	45	50	17	20	44	35	0	0.0354	1.000	1.000
452	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(6), ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), FPGT(7), GCK(9), GMDS(1), GMPPA(7), GMPPB(6), HK1(17), HK2(12), HK3(11), KHK(2), MPI(3), PFKFB1(6), PFKFB3(8), PFKFB4(5), PFKM(2), PFKP(21), PMM1(3), PMM2(2), SORD(3), TPI1(3)	13995465	161	86	156	51	64	25	18	22	32	0	0.0962	1.000	1.000
453	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(11), CS(1), DLAT(8), DLD(10), DLST(6), FH(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), OGDH(11), PC(18), PDHA1(1), PDHA2(11), PDHB(4), PDHX(5), PDK1(3), PDK2(1), PDK3(6), PDK4(5), PDP2(5), SDHA(11), SDHB(4), SDHC(2), SDHD(1), SUCLA2(3), SUCLG1(2), SUCLG2(8)	16636416	156	86	147	58	43	26	19	28	40	0	0.754	1.000	1.000
454	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(5), FADD(3), IKBKB(10), IL1A(2), IL1R1(4), IRAK1(7), MAP3K1(16), MAP3K7(11), MYD88(4), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TLR4(27), TNF(3), TNFAIP3(11), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6)	14231498	139	86	133	31	32	19	14	36	38	0	0.0367	1.000	1.000
455	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(11), F2R(6), F2RL3(4), GNAI1(3), GNB1(2), GNGT1(3), HRAS(1), ITGA1(7), ITGB1(11), MAP2K1(7), MAPK1(3), MAPK3(3), PLA2G4A(7), PLCB1(21), PRKCA(8), PTGS1(13), PTK2(11), RAF1(9), SRC(5), SYK(9), TBXAS1(7)	14280107	151	84	143	35	52	15	18	36	29	1	0.0119	1.000	1.000
456	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(2), CALM2(3), CALM3(1), CDKN1A(5), GNAQ(3), MARCKS(2), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), SP1(5), SP3(5), SYT1(5)	12309203	149	83	142	36	59	24	15	19	32	0	0.00258	1.000	1.000
457	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(3), ATG5(3), ATG7(9), BECN1(8), GABARAPL1(6), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(16), PIK3R4(10), PRKAA1(7), PRKAA2(10), ULK1(20), ULK2(11), ULK3(2)	12349690	138	83	130	35	26	18	21	39	33	1	0.182	1.000	1.000
458	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(10), CD2(4), CD33(9), CD5(4), CD7(5), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(3), IL12B(2), IL13(4), IL3(1), IL4(4), ITGAX(13), TLR2(4), TLR4(27), TLR7(6), TLR9(15)	10910712	119	82	113	41	32	14	15	41	17	0	0.378	1.000	1.000
459	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(17), EPHB1(33), FYN(9), ITGA1(7), ITGB1(11), L1CAM(18), LYN(7), RAP1B(6), SELP(11)	9261404	123	82	119	38	46	12	15	36	13	1	0.136	1.000	1.000
460	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(19), IL13(4), IL4(4), JUNB(5), MAF(4), MAP2K3(11), MAPK14(2), NFATC1(16), NFATC2(26), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	7104277	130	82	121	42	46	19	12	16	37	0	0.119	1.000	1.000
461	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(4), ALDH18A1(9), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AMD1(7), AOC2(10), AOC3(13), ARG1(2), ARG2(3), ASL(5), ASS1(10), CPS1(24), GATM(3), MAOA(4), MAOB(3), NAGS(1), ODC1(3), OTC(4), SAT1(2), SMS(6), SRM(1)	17246108	174	82	163	35	43	18	27	38	48	0	0.00790	1.000	1.000
462	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(14), BST1(3), CD38(5), ENPP1(7), ENPP3(12), NADK(11), NADSYN1(11), NMNAT1(4), NMNAT2(1), NMNAT3(3), NNMT(3), NNT(10), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT12(6)	12611311	130	82	120	42	32	16	20	20	41	1	0.433	1.000	1.000
463	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(7), ABAT(4), ADSL(5), ADSS(6), AGXT(3), AGXT2(13), ASL(5), ASNS(5), ASPA(2), CAD(20), CRAT(12), DARS(2), DDO(6), GAD1(8), GAD2(15), GOT1(3), GOT2(2), GPT(4), GPT2(3), NARS(5), PC(18)	15266820	148	81	142	57	52	20	17	26	33	0	0.621	1.000	1.000
464	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(7), CARS(6), DARS(2), EPRS(18), FARS2(9), GARS(3), HARS(9), IARS(11), KARS(7), LARS(9), LARS2(10), MARS(7), MARS2(5), NARS(5), QARS(7), RARS(5), SARS(9), TARS(11), WARS(4), WARS2(12), YARS(8)	18803806	164	81	159	44	47	21	28	30	38	0	0.109	1.000	1.000
465	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(8), AGT(4), AGTR2(4), EDN1(4), EDNRA(4), EDNRB(33), EGF(11), EGFR(19), FOS(1), HRAS(1), JUN(5), MYC(6), NFKB1(8), PLCG1(22), PRKCA(8), RELA(7)	12064525	145	81	132	39	39	19	14	36	37	0	0.117	1.000	1.000
466	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(8), CBS(9), CTH(3), GGT1(9), HEMK1(1), LCMT1(1), LCMT2(11), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), METTL6(5), PAPSS1(6), PAPSS2(6), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SCLY(4), SEPHS1(4), SEPHS2(3), WBSCR22(5)	14594112	142	80	134	45	36	18	24	23	40	1	0.275	1.000	1.000
467	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(10), CCNB1(3), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNH(3), CDC25A(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2A(17), CDKN2B(1), CDKN2C(1), CDKN2D(4), E2F1(4), RB1(14), RBL1(12), TFDP1(5)	9427471	105	79	103	35	20	20	13	24	27	1	0.509	1.000	1.000
468	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(4), ASNS(5), ASRGL1(4), CA1(1), CA12(1), CA13(4), CA14(5), CA2(7), CA3(4), CA4(6), CA5A(3), CA5B(1), CA6(3), CA7(3), CA8(4), CA9(7), CPS1(24), CTH(3), GLS(11), GLS2(8), GLUD1(4), GLUD2(13), GLUL(5), HAL(4)	12455509	134	79	128	41	30	15	25	34	30	0	0.385	1.000	1.000
469	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(7), CCR2(5), CCR3(12), CCR5(4), CCR7(4), CD28(1), CD4(11), CXCR3(2), IFNG(2), IFNGR1(10), IFNGR2(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18R1(6), IL4(4), IL4R(7), TGFB1(3), TGFB2(9), TGFB3(9)	11727453	123	79	115	40	29	11	19	29	35	0	0.542	1.000	1.000
470	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(46), EP300(27), LPL(9), NCOA1(20), NCOA2(27), PPARG(4), RXRA(13)	10837065	146	79	139	35	45	22	21	29	29	0	0.0201	1.000	1.000
471	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(25), APOA1(8), APOA4(8), APOC2(2), APOE(2), CETP(7), CYP7A1(7), DGAT1(10), HMGCR(7), LCAT(4), LDLR(12), LIPC(5), LPL(9), LRP1(54), SCARB1(4), SOAT1(11)	16067661	175	79	167	53	63	16	26	32	36	2	0.200	1.000	1.000
472	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(8), CREB1(4), CREBBP(46), EP300(27), NCOA3(15), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RARA(4), RXRA(13)	12122086	156	78	148	45	48	20	21	23	44	0	0.146	1.000	1.000
473	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(6), ALOX15(10), ALOX5(11), CYP1A2(5), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2J2(4), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), HSD3B7(7), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), RDH11(1), RDH12(3), RDH13(7)	14022676	134	78	126	46	46	14	23	31	19	1	0.460	1.000	1.000
474	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IL2RA(2), IL2RB(3), IL2RG(9), JAK1(19), JAK3(12), JUN(5), LCK(4), MAP2K1(7), MAPK3(3), MAPK8(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13), SYK(9)	13632147	142	78	132	32	31	23	14	34	38	2	0.0500	1.000	1.000
475	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(21), ADRB2(8), GNAS(38), PLCE1(17), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	8699774	123	78	117	46	50	15	12	21	24	1	0.687	1.000	1.000
476	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(14), AP2M1(8), ARF1(5), BAD(4), BTK(4), EEA1(15), GRASP(2), GSK3A(4), GSK3B(6), LYN(7), PDPK1(1), PFKL(8), PFKM(2), PFKP(21), PLCG1(22), PRKCE(14), PRKCZ(2), RAB5A(3), RAC1(1), RPS6KB1(6), VAV2(13)	14633280	165	78	159	49	57	25	20	24	38	1	0.143	1.000	1.000
477	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(4), ARSB(2), ARSD(5), ARSE(6), CYP11B1(17), CYP11B2(8), HSD11B1(4), HSD11B2(4), HSD17B2(3), HSD17B3(2), HSD3B1(4), HSD3B2(2), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5)	15957014	133	77	128	51	33	29	16	27	28	0	0.583	1.000	1.000
478	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(10), B3GAT2(7), B3GAT3(4), B4GALT7(6), CHPF(4), CHST11(4), CHST12(6), CHST13(5), CHST14(2), CHST3(8), CHST7(7), CHSY1(9), DSE(8), UST(10), XYLT1(11), XYLT2(43)	8160116	144	77	110	44	59	10	19	14	41	1	0.548	1.000	1.000
479	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(6), BCAT2(9), IARS(11), IARS2(12), ILVBL(8), LARS(9), LARS2(10), PDHA1(1), PDHA2(11), PDHB(4), VARS(23), VARS2(14)	10887719	118	76	116	37	34	14	17	30	23	0	0.387	1.000	1.000
480	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(4), B3GNT2(5), B3GNT7(6), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), CHST1(20), CHST2(15), CHST4(7), CHST6(11), FUT8(9), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7)	7319452	119	76	114	41	59	11	13	16	20	0	0.402	1.000	1.000
481	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IL6R(3), IL6ST(6), JAK1(19), JAK2(12), JAK3(12), JUN(5), MAP2K1(7), MAPK3(3), PTPN11(8), RAF1(9), SHC1(7), SOS1(9), SRF(5), STAT3(7)	13991149	127	76	118	39	27	20	15	34	28	3	0.372	1.000	1.000
482	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ACAA2(9), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1C4(5), AKR1D1(4), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), BAAT(6), CEL(16), CYP27A1(6), CYP7A1(7), HADHB(6), SOAT2(3), SRD5A1(2)	13605777	159	75	147	43	33	19	29	30	48	0	0.150	1.000	1.000
483	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(8), ARHGDIB(1), BIRC2(7), BIRC3(10), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP8(18), CASP9(3), DFFA(4), DFFB(3), GZMB(2), LMNA(11), LMNB1(4), LMNB2(6), PRF1(13)	11316287	118	75	113	29	27	14	19	22	36	0	0.224	1.000	1.000
484	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(5), CSF1R(17), EGF(11), EGFR(19), GRB2(4), MET(10), PDGFRA(13), PRKCA(8), SH3GLB1(3), SH3GLB2(8), SH3KBP1(17), SRC(5)	11398215	120	75	112	56	32	18	9	26	35	0	0.977	1.000	1.000
485	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(21), ADRB2(8), CFTR(15), GNAS(38), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), SLC9A3R1(1)	7688595	122	75	116	35	46	12	11	22	30	1	0.355	1.000	1.000
486	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(5), ELK1(4), EPO(3), EPOR(3), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAP2K1(7), MAPK3(3), MAPK8(6), PLCG1(22), PTPN6(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13)	12603739	130	75	126	31	38	20	15	27	29	1	0.0336	1.000	1.000
487	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(10), RPE(5), UGDH(8), UGP2(9), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), XYLB(6)	15889679	140	75	132	30	20	15	26	33	46	0	0.0607	1.000	1.000
488	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(8), FUCA1(1), FUCA2(2), GLB1(7), HEXA(2), HEXB(3), LCT(24), MAN2B1(19), MAN2B2(19), MAN2C1(11), MANBA(10), NEU1(3), NEU2(7), NEU3(5), NEU4(3)	11920709	124	75	120	31	42	18	17	18	29	0	0.0481	1.000	1.000
489	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(3), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), HGSNAT(5), HPSE(11), HPSE2(10), HYAL1(7), HYAL2(8), IDS(4), IDUA(4), LCT(24), NAGLU(8), SPAM1(10)	11967757	126	75	124	39	37	25	20	19	25	0	0.219	1.000	1.000
490	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(6), GPLD1(13), PGAP1(11), PIGA(3), PIGB(10), PIGC(6), PIGG(15), PIGK(3), PIGL(5), PIGM(4), PIGN(6), PIGO(10), PIGP(1), PIGQ(9), PIGS(4), PIGT(11), PIGV(7), PIGW(5), PIGX(3), PIGZ(10)	13899980	142	75	129	39	34	15	17	32	43	1	0.295	1.000	1.000
491	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(4), BLVRB(1), CP(10), CPOX(4), EPRS(18), FECH(7), GUSB(10), HCCS(4), HMBS(3), HMOX1(7), HMOX2(1), PPOX(6), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5), UROD(2), UROS(5)	16012915	136	75	131	44	30	21	16	31	38	0	0.505	1.000	1.000
492	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(5), CREBBP(46), EP300(27), FADD(3), HDAC3(7), IKBKB(10), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6)	13090035	137	75	132	38	42	21	14	24	36	0	0.125	1.000	1.000
493	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(11), ACE2(11), AGT(4), AGTR1(1), AGTR2(4), ANPEP(10), CMA1(2), CPA3(4), CTSA(5), CTSG(4), ENPEP(15), LNPEP(12), MAS1(3), MME(10), NLN(7), REN(7), THOP1(6)	12388106	116	74	113	42	32	14	18	24	28	0	0.613	1.000	1.000
494	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(3), CHUK(5), CRADD(6), IKBKB(10), JUN(5), LTA(4), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP4K2(10), MAPK14(2), MAPK8(6), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TANK(3), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4)	14086534	125	74	122	37	31	17	14	18	43	2	0.291	1.000	1.000
495	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(4), ARSB(2), ARSD(5), ARSE(6), ASAH1(4), GAL3ST1(12), GALC(5), GBA(12), GLA(3), GLB1(7), LCT(24), NEU1(3), NEU2(7), NEU3(5), NEU4(3), PPAP2A(3), PPAP2B(2), PPAP2C(6), SMPD1(6), SMPD2(3), SPTLC1(5), SPTLC2(4), UGCG(3)	14163863	134	72	130	51	43	18	25	20	28	0	0.673	1.000	1.000
496	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), AOC2(10), AOC3(13), ASPA(2), CNDP1(5), DDC(12), HAL(4), HARS(9), HDC(11), HNMT(2), MAOA(4), MAOB(3), PRPS1(3), PRPS2(3)	14306377	159	72	143	38	39	13	20	29	57	1	0.186	1.000	1.000
497	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), ZNRD1(2)	13759882	124	72	121	36	40	13	22	25	24	0	0.167	1.000	1.000
498	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), G6PD(6), GPI(6), H6PD(7), PFKL(8), PFKM(2), PFKP(21), PGD(8), PGLS(1), PGM1(3), PGM3(13), PRPS1(3), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TALDO1(6), TKT(5), TKTL1(11), TKTL2(12)	14222969	152	70	144	44	40	30	18	32	32	0	0.0567	1.000	1.000
499	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(4), B3GNT2(5), B3GNT3(3), B3GNT4(9), B3GNT5(11), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), FUT1(5), FUT2(2), FUT3(4), FUT4(2), FUT5(3), FUT6(6), FUT7(3), FUT9(7), GCNT2(1), ST3GAL6(6), ST8SIA1(12)	9479775	102	70	95	38	30	13	12	21	26	0	0.781	1.000	1.000
500	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(8), B4GALNT1(4), GLB1(7), HEXA(2), HEXB(3), LCT(24), SLC33A1(5), ST3GAL1(5), ST3GAL2(9), ST3GAL5(2), ST6GALNAC3(6), ST6GALNAC4(3), ST6GALNAC5(9), ST6GALNAC6(4), ST8SIA1(12), ST8SIA5(8)	9662814	111	70	108	44	43	12	15	20	21	0	0.723	1.000	1.000
501	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(2), MRPS7(1), RPL10A(6), RPL10L(14), RPL11(1), RPL12(3), RPL13A(4), RPL14(2), RPL18(1), RPL18A(1), RPL19(1), RPL22L1(1), RPL23A(3), RPL24(2), RPL26(1), RPL27(1), RPL28(1), RPL29(2), RPL3(3), RPL31(2), RPL34(1), RPL35A(1), RPL36A(3), RPL37(1), RPL38(1), RPL3L(3), RPL6(3), RPL8(3), RPL9(4), RPS10(1), RPS11(1), RPS13(2), RPS16(1), RPS18(1), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(1), RPS26(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS7(1), RPS9(2), RPSA(5)	13258046	105	70	101	40	24	15	15	25	26	0	0.937	1.000	1.000
502	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37)	9812143	112	69	109	39	32	19	11	15	35	0	0.647	1.000	1.000
503	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(17), DDX20(3), E2F1(4), E2F4(2), ETS1(8), ETS2(4), ETV3(1), FOS(1), HDAC2(6), HDAC5(13), HRAS(1), JUN(5), NCOR2(40), RBL1(12), RBL2(7), SIN3A(15), SIN3B(15)	15152563	159	69	156	39	46	17	21	30	42	3	0.0876	1.000	1.000
504	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGAM(10), ITGB1(11), ITGB2(12), SELE(6), SELL(6), SELP(11)	9332300	106	69	101	35	35	5	13	28	25	0	0.263	1.000	1.000
505	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(4), ASNS(5), CA1(1), CA12(1), CA14(5), CA2(7), CA3(4), CA4(6), CA5A(3), CA5B(1), CA6(3), CA7(3), CA8(4), CA9(7), CPS1(24), CTH(3), GLS(11), GLS2(8), GLUD1(4), GLUL(5), HAL(4)	11147941	113	69	107	35	24	13	22	26	28	0	0.467	1.000	1.000
506	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(7), ACO2(11), CS(1), DLD(10), DLST(6), FH(4), IDH1(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), PC(18), PCK1(12), SDHA(11), SDHB(4), SUCLA2(3), SUCLG1(2), SUCLG2(8)	12082327	116	68	110	37	43	18	10	15	30	0	0.288	1.000	1.000
507	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(11), EGFR(19), MAP2K1(7), MAP3K1(16), MAPK14(2), NCOR2(40), RARA(4), RXRA(13), THRA(7), THRB(4)	10081298	123	68	115	38	49	14	11	21	25	3	0.280	1.000	1.000
508	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(8), F2(11), F2R(6), F3(2), F5(22), F7(11), FGA(12), FGB(6), FGG(5), PROC(4), PROS1(11), SERPINC1(5), TFPI(5)	9627975	108	68	107	31	30	15	15	31	17	0	0.248	1.000	1.000
509	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CYP2C19(8), CYP2C9(1), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ECHS1(2), EHHADH(4), ESCO1(10), ESCO2(10), HADHA(5), NAT6(4), PNPLA3(4), SH3GLB1(3), YOD1(1)	18120585	133	68	121	34	32	14	16	22	49	0	0.246	1.000	1.000
510	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22(2), IL22RA1(2), IL22RA2(1), JAK1(19), JAK2(12), JAK3(12), SOCS3(3), STAT1(11), STAT3(7), STAT5A(10), STAT5B(13), TYK2(12)	10743415	109	68	105	35	27	15	13	20	31	3	0.552	1.000	1.000
511	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(5), ARFGAP1(5), ARFGAP3(6), ARFGEF2(31), CLTA(2), CLTB(2), COPA(13), GBF1(22), GPLD1(13), KDELR1(2), KDELR2(3), KDELR3(2)	9535763	106	67	106	29	33	18	16	20	19	0	0.0934	1.000	1.000
512	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(14), AMT(4), ATIC(5), FTCD(7), GART(10), MTFMT(2), MTHFD1(7), MTHFD1L(8), MTHFD2(1), MTHFR(10), MTHFS(3), MTR(19), SHMT1(2), SHMT2(11), TYMS(1)	11082523	104	67	100	28	27	14	14	21	27	1	0.0689	1.000	1.000
513	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), MDH1(3), ME1(1), ME3(7), PGK1(4), PGK2(3), PKLR(9), RPE(5), RPIA(2), TKT(5), TKTL1(11), TKTL2(12), TPI1(3)	11828319	104	67	103	57	30	24	12	21	17	0	0.978	1.000	1.000
514	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(6), GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), GPHN(13), NSF(2), SRC(5), UBQLN1(6)	7007410	102	66	99	31	21	10	23	35	13	0	0.328	1.000	1.000
515	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT5(4), DPAGT1(6), DPM1(2), FUT8(9), MAN1A1(4), MAN1B1(6), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), RPN1(4), RPN2(6), ST6GAL1(1)	11666192	100	66	97	38	31	13	11	20	25	0	0.700	1.000	1.000
516	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(16), LPO(11), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), TPO(27), TYR(15)	5631167	83	66	78	26	27	10	8	25	12	1	0.404	1.000	1.000
517	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8), MASP1(3), MASP2(6), MBL2(4)	12484355	114	65	108	33	35	15	13	23	28	0	0.223	1.000	1.000
518	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), AMD1(7), BHMT(5), CBS(9), CTH(3), DNMT1(19), DNMT3A(7), DNMT3B(15), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), MTAP(2), MTFMT(2), MTR(19), SRM(1), TAT(5)	12127607	121	65	119	53	37	14	25	25	20	0	0.862	1.000	1.000
519	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(8), GALNT2(7), GALNT3(4), GALNT4(6), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GCNT1(1), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), WBSCR17(27)	8464373	97	65	94	36	39	8	13	18	18	1	0.821	1.000	1.000
520	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), G6PD(6), GPI(6), H6PD(7), PFKM(2), PFKP(21), PGD(8), PGLS(1), PGM1(3), PGM3(13), PRPS1(3), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TAL1(5), TALDO1(6), TKT(5)	11985956	126	65	119	35	33	24	14	28	27	0	0.0534	1.000	1.000
521	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C8B(11), C9(8), MASP1(3)	12189996	115	64	109	30	36	13	15	26	25	0	0.127	1.000	1.000
522	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(10), G6PD(6), GCLC(3), GCLM(3), GGT1(9), GPX5(2), GPX7(3), GSR(5), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), IDH1(4), IDH2(4), MGST1(3), MGST2(3), MGST3(3), OPLAH(25), TXNDC12(3)	12868773	115	64	107	39	32	17	11	23	31	1	0.675	1.000	1.000
523	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(13), CNR2(3), DNMT1(19), MTNR1A(4), MTNR1B(8), PTAFR(4), PTGDR(8), PTGER2(7), PTGER4(12), PTGFR(5), TBXA2R(9)	6518288	92	64	88	43	39	12	15	16	10	0	0.682	1.000	1.000
524	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(4), JAK1(19), JAK2(12), JAK3(12), PIAS1(10), PIAS3(10), PTPRU(26), REG1A(4), SOAT1(11)	8022420	108	64	96	32	31	16	9	12	37	3	0.551	1.000	1.000
525	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(5), DUSP1(3), IKBKAP(14), IKBKB(10), LTA(4), MAP3K1(16), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TANK(3), TNFAIP3(11), TNFRSF1B(3), TRAF1(4), TRAF2(4), TRAF3(7)	13153352	103	64	99	33	32	14	8	15	33	1	0.460	1.000	1.000
526	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), MDH1(3), ME1(1), ME2(7), ME3(7), PGK1(4), PKLR(9), RPE(5), RPIA(2), TKT(5), TPI1(3)	10571491	85	63	85	46	22	20	10	16	17	0	0.964	1.000	1.000
527	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(9), ACP2(5), ACP5(3), ACP6(3), ACPP(5), ACPT(6), ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), PON1(3), PON2(3), PON3(5)	10574025	107	63	99	44	37	11	12	20	27	0	0.812	1.000	1.000
528	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(4), IL6R(3), JAK1(19), JAK2(12), JAK3(12), PIAS3(10), PTPRU(26), REG1A(4), SRC(5), STAT3(7)	8918107	102	63	94	31	31	15	9	16	28	3	0.434	1.000	1.000
529	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(9), CLOCK(8), CRY1(3), CRY2(7), CSNK1D(4), CSNK1E(9), NPAS2(14), NR1D1(9), PER1(6), PER2(15), PER3(13)	9979085	97	61	94	27	33	12	10	18	24	0	0.149	1.000	1.000
530	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(4), CHUK(5), IFNG(2), IKBKB(10), IL4(4), JUN(5), MAP3K1(16), MAP3K5(10), MAP4K5(4), MAPK14(2), MAPK8(6), NFKB1(8), NFKBIA(1), RELA(7), TNFRSF9(11), TRAF2(4)	11327837	99	60	91	22	25	11	7	17	38	1	0.131	1.000	1.000
531	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(17), KHK(2), LCT(24), MPI(3), PGM1(3), PYGL(11), PYGM(14), TPI1(3), TREH(3)	7844858	80	60	79	28	34	15	7	10	14	0	0.292	1.000	1.000
532	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(9), CYP51A1(9), DHCR24(4), DHCR7(7), EBP(2), FDFT1(3), FDPS(12), GGCX(4), GGPS1(4), HMGCR(7), HSD17B7(5), IDI1(2), IDI2(3), LSS(14), MVD(2), MVK(15), NQO1(3), NSDHL(4), PMVK(1), SQLE(9), TM7SF2(4), VKORC1(1)	11247026	124	60	110	32	29	12	13	26	44	0	0.381	1.000	1.000
533	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3E(2), CXCR3(2), ETV5(7), IFNG(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18(1), IL18R1(6), JAK2(12), JUN(5), MAP2K6(1), MAPK14(2), MAPK8(6), STAT4(9), TYK2(12)	10910334	95	60	95	31	18	15	18	19	24	1	0.410	1.000	1.000
534	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(12), FOS(1), GRB2(4), HRAS(1), IL3(1), IL3RA(5), JAK2(12), MAP2K1(7), MAPK3(3), PTPN6(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13)	10370215	100	60	96	33	28	16	12	23	20	1	0.439	1.000	1.000
535	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(8), FUCA1(1), FUCA2(2), GLB1(7), HEXA(2), HEXB(3), LCT(24), MAN2C1(11), MANBA(10), NEU1(3), NEU2(7), NEU3(5), NEU4(3)	9669989	86	60	85	29	26	15	10	13	22	0	0.526	1.000	1.000
536	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(5), FUT1(5), FUT2(2), FUT9(7), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), ST8SIA1(12)	5935240	72	59	69	27	31	7	6	20	8	0	0.520	1.000	1.000
537	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(14), CD38(5), ENPP1(7), ENPP3(12), NADSYN1(11), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(10), NT5E(5), NT5M(6)	8519417	78	59	72	28	9	9	14	16	29	1	0.783	1.000	1.000
538	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), NCK1(6), NCKAP1(13), NTRK1(9), PIR(1), PSMA7(3), RAC1(1), WASF1(8), WASF2(7), WASF3(20), WASL(5)	8950930	92	58	84	34	29	8	9	14	29	3	0.802	1.000	1.000
539	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(5), B3GALNT1(5), B3GALT5(2), FUT1(5), FUT2(2), FUT9(7), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(5), ST3GAL2(9), ST8SIA1(12)	6300423	72	58	68	32	29	7	6	20	10	0	0.815	1.000	1.000
540	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(4), IL2RG(9), IL4(4), IL4R(7), IRS1(27), JAK1(19), JAK3(12), RPS6KB1(6), SHC1(7), STAT6(7)	8642708	105	57	93	28	23	13	12	11	43	3	0.628	1.000	1.000
541	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(5), CBS(9), CTH(3), DNMT1(19), DNMT3A(7), DNMT3B(15), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), MTR(19)	10172520	104	57	102	45	35	10	22	18	19	0	0.819	1.000	1.000
542	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(4), CD2(4), CD3E(2), CD4(11), CXCR3(2), IFNG(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), JAK2(12), STAT4(9), TYK2(12)	8587845	82	57	77	33	15	12	15	16	23	1	0.865	1.000	1.000
543	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), B4GALT7(6), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), XYLT1(11), XYLT2(43)	3795896	90	56	59	30	33	4	12	8	32	1	0.865	1.000	1.000
544	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), B4GALT7(6), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), XYLT1(11), XYLT2(43)	3795896	90	56	59	30	33	4	12	8	32	1	0.865	1.000	1.000
545	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(5), DUSP1(3), IKBKAP(14), IKBKB(10), MAP3K1(16), NFKB1(8), NFKBIA(1), RELA(7), TNFAIP3(11), TRAF3(7), TRAF6(6)	10622692	88	55	84	24	27	10	7	13	31	0	0.348	1.000	1.000
546	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(6), ACAT2(5), ACOT11(5), ACYP1(1), ACYP2(3), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ECHS1(2), EHHADH(4), ESCO1(10), ESCO2(10), FN3K(4), GCDH(7), HADHA(5), NAT6(4), PNPLA3(4), SH3GLB1(3), YOD1(1)	15238840	93	55	87	17	19	13	14	11	36	0	0.0353	1.000	1.000
547	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(9), ARG1(2), ARG2(3), ASL(5), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), GAMT(1), GATM(3), GLUD1(4), NAGS(1), OAT(3), ODC1(3), OTC(4), PYCR1(3), SMS(6)	10237158	92	55	92	27	30	9	14	24	15	0	0.191	1.000	1.000
548	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(5), ACAD9(8), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ESCO1(10), ESCO2(10), NAT6(4), PNPLA3(4), SH3GLB1(3)	14646158	92	54	89	15	21	8	16	18	29	0	0.0109	1.000	1.000
549	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(8), ESR2(9), ITPKA(2), PDE1A(7), PDE1B(5), PLCB1(21), PLCB2(8), PRL(1), TRH(5), VIP(7)	6511891	73	54	70	28	23	10	11	19	10	0	0.628	1.000	1.000
550	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(1), CD3E(2), CD4(11), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21), THY1(1)	6611545	78	54	69	35	19	7	10	19	23	0	0.934	1.000	1.000
551	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(10), G6PD(6), GCLC(3), GCLM(3), GGT1(9), GPX5(2), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), IDH1(4), IDH2(4), MGST1(3), MGST2(3), MGST3(3), PGD(8)	10549227	84	53	80	28	23	15	8	18	20	0	0.544	1.000	1.000
552	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(10), CCNA2(1), CCND1(2), CCNE1(5), CCNE2(3), CDK2(4), CDK4(2), CDKN1B(1), CDKN2A(17), E2F1(4), E2F2(5), E2F4(2), PRB1(3)	5251336	59	53	58	22	9	14	7	14	14	1	0.619	1.000	1.000
553	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(3), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), IDS(4), IDUA(4), LCT(24), NAGLU(8)	8396178	75	52	74	30	22	14	10	12	17	0	0.655	1.000	1.000
554	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(1), CD3E(2), CD8A(4), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21), THY1(1)	6301491	71	52	67	30	19	7	11	17	17	0	0.743	1.000	1.000
555	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(3), ACOX3(13), ELOVL2(7), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(4), FASN(27), HADHA(5), HSD17B12(4), PECR(1), SCD(1)	8331084	73	51	66	30	29	8	12	6	18	0	0.697	1.000	1.000
556	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(9), DLL1(16), FURIN(6), NOTCH1(31), PSEN1(5)	5399864	67	51	64	31	21	8	7	13	18	0	0.779	1.000	1.000
557	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(15), EGF(11), EGFR(19), HGS(5), RAB5A(3), TF(15), TFRC(2)	7533894	70	50	68	32	20	10	6	19	14	1	0.887	1.000	1.000
558	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACADM(7), ACADS(4), ACADVL(3), ACSL1(4), ACSL3(7), ACSL4(6), CPT1A(14), CPT2(7), EHHADH(4), HADHA(5), PECR(1), SCP2(5), SLC25A20(4)	9861974	74	50	71	18	19	6	11	14	24	0	0.112	1.000	1.000
559	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD4(11), FYN(9), HLA-DRA(7), HLA-DRB1(1), LCK(4), PTPRC(21), ZAP70(13)	5308172	68	50	61	32	20	8	10	18	12	0	0.939	1.000	1.000
560	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(13), FADS2(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8)	5934758	66	49	57	23	27	3	9	21	6	0	0.569	1.000	1.000
561	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(8), ESR1(8), GREB1(26), HSPB1(2), HSPB2(1), MTA1(10), MTA3(3), PDZK1(2), TUBA8(6)	6370233	67	49	65	30	25	12	9	6	15	0	0.726	1.000	1.000
562	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(10), RPE(5), UCHL1(3), UCHL3(4), UGDH(8), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5)	10246111	87	49	82	21	19	9	17	16	26	0	0.103	1.000	1.000
563	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14)	7864391	73	49	71	25	25	9	15	11	13	0	0.374	1.000	1.000
564	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(15), CHAT(6), CHKA(2), PCYT1A(9), PDHA1(1), PDHA2(11), PEMT(1), SLC18A3(16)	4073466	61	48	61	29	25	6	7	17	6	0	0.778	1.000	1.000
565	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(9), DHCR7(7), FDFT1(3), FDPS(12), HMGCR(7), HMGCS1(2), IDI1(2), LSS(14), MVD(2), MVK(15), NSDHL(4), PMVK(1), SQLE(9)	7684414	87	48	76	23	21	7	6	20	33	0	0.432	1.000	1.000
566	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(8), ICAM1(4), ITGAL(22), ITGAM(10), ITGB2(12), SELE(6), SELL(6)	6070330	68	48	66	27	24	4	8	15	17	0	0.602	1.000	1.000
567	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(19), JAK2(12), JAK3(12), MAPK1(3), MAPK3(3), STAT3(7), TYK2(12)	6836561	68	48	64	23	14	11	10	11	19	3	0.697	1.000	1.000
568	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(4), CYP11A1(6), CYP11B1(17), CYP11B2(8), CYP17A1(7), CYP21A2(6), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2)	5430778	67	47	66	25	23	12	7	16	9	0	0.593	1.000	1.000
569	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(4), CYP11A1(6), CYP11B1(17), CYP11B2(8), CYP17A1(7), CYP21A2(6), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2)	5430778	67	47	66	25	23	12	7	16	9	0	0.593	1.000	1.000
570	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(9), CTH(3), GGT1(9), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), PAPSS1(6), PAPSS2(6), SCLY(4), SEPHS1(4)	7240494	68	47	65	27	21	8	13	9	17	0	0.635	1.000	1.000
571	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(4), IL13RA1(5), IL13RA2(7), IL4R(7), JAK1(19), JAK2(12), TYK2(12)	6138326	66	47	63	22	14	12	10	8	19	3	0.642	1.000	1.000
572	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(4), IL13RA1(5), IL13RA2(7), IL4R(7), JAK1(19), JAK2(12), TYK2(12)	6138326	66	47	63	22	14	12	10	8	19	3	0.642	1.000	1.000
573	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(11), AGT(4), AGTR1(1), AGTR2(4), BDKRB2(3), KNG1(11), NOS3(15), REN(7)	5745741	56	46	52	20	15	5	8	8	20	0	0.614	1.000	1.000
574	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(7), CDO1(3), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), MPST(3), SDS(4), SULT1B1(6), SULT1C2(2), SULT1C4(4), SULT4A1(1)	7348727	64	46	64	22	20	15	7	9	13	0	0.435	1.000	1.000
575	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(9), ENO1(3), GPI(6), HK1(17), PFKL(8), PGAM1(1), PGK1(4), PKLR(9), TPI1(3)	5416318	60	45	60	23	18	17	4	14	7	0	0.380	1.000	1.000
576	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(7), CAPNS1(3), CAPNS2(2), CDK5(3), CDK5R1(5), CSNK1A1(5), CSNK1D(4), GSK3B(6), MAPT(11), PPP2CA(4)	5398060	59	44	58	19	19	12	6	11	11	0	0.285	1.000	1.000
577	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(21), EIF2AK4(10), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF5(6), GSK3B(6), PPP1CA(2)	6782053	60	43	60	16	13	3	12	19	13	0	0.351	1.000	1.000
578	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(8), HDAC9(12), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MYOD1(7), YWHAH(3)	4522191	54	43	53	21	14	4	8	11	17	0	0.656	1.000	1.000
579	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMC3(9), PSMD14(1), RPN1(4), RPN2(6), UBE2A(1), UBE3A(5)	7567166	63	43	63	17	16	5	18	11	13	0	0.222	1.000	1.000
580	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(5), ALAS2(14), CPOX(4), FECH(7), HMBS(3), PPOX(6), UROD(2), UROS(5)	4429524	50	42	49	14	13	12	3	12	10	0	0.354	1.000	1.000
581	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(7), ACO2(11), AFMID(4), CS(1), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(8), MTHFD2(1)	7857617	59	42	58	22	17	16	5	8	13	0	0.486	1.000	1.000
582	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(6), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), HSD3B7(7), PON1(3), PON2(3), PON3(5), RDH11(1), RDH12(3), RDH13(7)	5275506	54	41	52	20	19	8	7	13	7	0	0.554	1.000	1.000
583	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(7), MMP2(10), MMP9(20), RECK(6), TIMP1(1), TIMP2(1), TIMP3(10), TIMP4(1)	4405603	57	41	54	28	21	12	3	9	10	2	0.820	1.000	1.000
584	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(4), ALAS1(5), ALAS2(14), CPO(4), FECH(7), GATA1(3), HBB(2), HMBS(3), UROD(2), UROS(5)	4580122	49	40	48	16	13	9	4	12	11	0	0.525	1.000	1.000
585	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(5), ADSS(6), IMPDH1(6), MTHFD2(1), NME2(3), OAZ1(3), POLB(6), POLD1(15), POLG(10), PRPS2(3), RRM1(5), SRM(1)	7314719	64	40	63	19	20	16	5	9	14	0	0.239	1.000	1.000
586	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(7), ACO2(11), CS(1), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(8), MTHFD2(1)	7504146	55	39	54	22	16	15	5	8	11	0	0.605	1.000	1.000
587	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(8), BCL2(4), CASP3(2), CASP9(3), DAXX(11), FAS(3), FASLG(5), HSPB1(2), HSPB2(1), IL1A(2), MAPKAPK2(3), MAPKAPK3(5), TNF(3)	6646269	56	39	56	20	17	7	4	15	13	0	0.540	1.000	1.000
588	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(6), IARS(11), LARS(9), LARS2(10), PDHA1(1), PDHA2(11), PDHB(4)	5872001	52	39	51	21	8	7	10	16	11	0	0.831	1.000	1.000
589	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), FPGS(7), GCH1(1), GGH(2), SPR(2)	3816869	45	38	44	21	25	4	1	7	8	0	0.552	1.000	1.000
590	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(11), CS(1), FH(4), IDH2(4), MDH1(3), OGDH(11), SDHA(11), SUCLA2(3)	5524992	48	37	44	19	16	8	3	5	16	0	0.773	1.000	1.000
591	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(9), FARSA(6), FARSB(3), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(8), YARS2(2)	5102813	44	36	44	18	15	7	4	11	7	0	0.765	1.000	1.000
592	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(3), B3GALT2(8), B3GALT5(2), B3GNT5(11), FUT1(5), FUT2(2), FUT3(4), ST3GAL3(2), ST3GAL4(7)	4237363	44	36	41	19	19	5	2	5	13	0	0.888	1.000	1.000
593	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(6), CYP11A1(6), CYP11B2(8), CYP17A1(7), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2)	4055785	41	33	41	21	12	4	6	11	8	0	0.947	1.000	1.000
594	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(2), EHHADH(4), HADH(2), HADHA(5), HSD17B4(7), NTAN1(5), SIRT1(8), SIRT2(4), SIRT5(4), SIRT7(5), VNN2(4)	6946391	53	33	49	14	13	8	7	7	18	0	0.249	1.000	1.000
595	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(10), CKM(1), EIF4E(2), FBL(6), GPT(4), LDHA(7), LDHB(5), LDHC(1), MAPK14(2), NCL(7)	5260807	45	33	44	18	11	12	2	11	9	0	0.769	1.000	1.000
596	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(6), ACAT2(5), BDH1(7), HMGCS1(2), HMGCS2(4), OXCT1(10), OXCT2(6)	4217793	40	32	38	16	12	7	4	5	12	0	0.797	1.000	1.000
597	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), NFS1(1), PHPT1(2), THTPA(2), TPK1(5)	3760869	38	32	37	12	8	5	7	5	13	0	0.485	1.000	1.000
598	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(12), GOT1(3), GOT2(2), TAT(5), TYR(15)	2759002	37	32	30	13	7	5	4	10	10	1	0.796	1.000	1.000
599	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), LTB4R(2), P2RY1(3), P2RY2(5), P2RY6(10)	3494679	37	32	36	21	23	2	1	5	6	0	0.858	1.000	1.000
600	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(9), CLOCK(8), CRY1(3), CRY2(7), CSNK1E(9), PER1(6)	4959498	42	31	40	14	16	6	3	5	12	0	0.634	1.000	1.000
601	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(3), ENO3(4), FARS2(9), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(8)	4872049	43	31	43	16	14	9	4	9	7	0	0.465	1.000	1.000
602	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(8), TAX1BP3(1), UBE2A(1), UBE2C(1), UBE2D3(1), UBE2E1(2), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(5), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(2), UBE2S(3), UBE3A(5)	6163233	42	31	42	13	18	6	4	6	8	0	0.180	1.000	1.000
603	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(8), AASDH(10), AASDHPPT(1), AASS(10), KARS(7)	4083810	36	30	36	11	7	6	8	7	8	0	0.453	1.000	1.000
604	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(11), CS(1), MDH1(3), ME1(1), PC(18), PDHA1(1), SLC25A1(3), SLC25A11(2)	5427701	40	30	39	20	15	6	6	7	6	0	0.888	1.000	1.000
605	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB10(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMB8(5), PSMB9(2)	5126308	46	30	46	14	15	4	10	8	9	0	0.371	1.000	1.000
606	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(4), FUT1(5), FUT2(2), FUT9(7), GCNT2(1), ST8SIA1(12)	3596976	31	28	29	16	11	2	3	11	4	0	0.875	1.000	1.000
607	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(5), CDC25B(6), CDKN1A(5), CHEK1(6), NEK1(6), WEE1(6)	4029715	34	28	34	11	7	6	4	7	10	0	0.717	1.000	1.000
608	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(8), NDUFA1(1), SDHA(11), SDHB(4), SDHC(2), SDHD(1), UQCRC1(3)	3879239	33	27	33	12	11	4	5	6	7	0	0.472	1.000	1.000
609	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), RAC1(1), WASF1(8), WASL(5)	4764757	36	25	36	19	8	5	4	6	13	0	0.972	1.000	1.000
610	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHB(5), LDHC(1), MPST(3)	4012305	30	23	30	13	10	8	5	2	5	0	0.732	1.000	1.000
611	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(6), EPHX2(3), HSD3B7(7), RDH11(1), RDH12(3), RDH13(7)	2812442	27	23	26	11	10	5	3	4	5	0	0.674	1.000	1.000
612	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(5), FUT2(2), FUT3(4), FUT5(3), FUT6(6), ST3GAL3(2)	2988972	22	19	22	15	12	3	2	2	3	0	0.956	1.000	1.000
613	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(6), RDH5(3)	2289730	15	15	15	10	4	1	1	5	4	0	0.982	1.000	1.000
614	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(3), RAB27A(4), RAB3A(1), RAB4A(1), RAB5A(3)	2489670	16	12	16	16	6	1	4	2	3	0	0.991	1.000	1.000
615	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(5), PGLYRP2(6)	1060870	11	10	11	6	8	1	2	0	0	0	0.806	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		299280	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
