rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(10), FMOD(12), KERA(5), LUM(8)	2129598	36	29	36	4	14	2	4	12	4	0	0.0127	0.160	1.000
2	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(7), GRIA2(26), JUND(2), PPP1R1B(3)	2191409	41	34	41	7	8	9	6	11	7	0	0.0317	0.209	1.000
3	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(4), LIPT1(5)	895003	9	9	8	1	2	3	1	0	2	1	0.207	0.416	1.000
4	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(7), GSTZ1(2), HGD(6)	1306926	15	15	13	3	4	0	3	4	4	0	0.398	0.529	1.000
5	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(3), SEC61A2(4), SRP19(3), SRP54(6), SRP68(6), SRP72(14), SRP9(2), SRPR(16)	4424708	54	42	52	5	15	7	10	5	17	0	0.00309	0.675	1.000
6	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(3), TGDS(5), UGDH(8), UXS1(8)	2256701	25	22	25	3	9	2	6	4	4	0	0.0333	0.688	1.000
7	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(3)	965217	9	9	9	2	4	2	1	1	1	0	0.360	0.704	1.000
8	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(1), ALDOB(9), ALDOC(7), TPI1(3)	2295817	26	25	26	4	6	7	3	6	4	0	0.0607	0.784	1.000
9	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), FDPS(12), IDI1(2), SQLE(9)	1868455	26	19	25	3	7	3	3	4	9	0	0.0499	0.785	1.000
10	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(3), TGDS(5), UGDH(8), UGP2(9), UXS1(8)	2875221	34	27	33	4	11	2	6	6	9	0	0.0275	0.785	1.000
11	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(5), CDK2(4), CDKN1B(1), CKS1B(2), CUL1(24), E2F1(4), RB1(14), RBX1(1), SKP2(6), TFDP1(5), UBE2M(1)	5045457	67	49	67	10	10	9	14	11	23	0	0.00671	0.867	1.000
12	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), FDPS(12), GGPS1(4), IDI1(2), IDI2(3), SQLE(9)	2503359	33	22	32	4	8	4	3	6	12	0	0.0438	0.892	1.000
13	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(5), CDC34(2), CDK2(4), CUL1(24), E2F1(4), RB1(14), TFDP1(5)	3875128	58	45	58	10	12	6	13	10	17	0	0.0163	0.892	1.000
14	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(6), CCL2(1), CSF1(5), LDLR(12), LPL(9)	3127094	33	30	31	6	10	4	3	4	12	0	0.0688	0.925	1.000
15	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(11), HLA-DRA(7), HLA-DRB1(1)	1393636	20	20	15	8	5	2	2	3	8	0	0.914	0.972	1.000
16	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2)	668133	2	2	2	1	0	0	2	0	0	0	0.759	0.972	1.000
17	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(4), LPL(9), NR3C1(9), PPARG(4), RETN(1), RXRA(13), TNF(3)	3397366	43	39	41	10	11	4	6	12	10	0	0.214	0.978	1.000
18	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	4	AOC2(10), AOC3(13), ESD(1)	3020311	24	21	22	2	4	1	3	5	11	0	0.233	0.980	1.000
19	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(33), ABCB11(11), ABCB4(29), ABCC1(14), ABCC3(14), GSTP1(1)	8412303	102	73	96	16	26	11	12	18	35	0	0.00259	0.984	1.000
20	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(3), CCR3(12), HLA-DRA(7), HLA-DRB1(1), IL3(1)	1784846	25	20	24	6	9	4	3	6	3	0	0.186	0.984	1.000
21	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(6), SLPI(2)	1005759	8	7	8	3	4	1	0	1	2	0	0.652	0.986	1.000
22	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(8), SUCLA2(3)	1240358	11	11	11	3	6	0	1	1	3	0	0.534	0.991	1.000
23	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(6), ACAT2(5), OXCT1(10)	1985949	21	20	20	7	3	6	2	3	7	0	0.780	0.993	1.000
24	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(5), FOS(1), FYN(9), JUN(5), MAPK14(2), THBS1(17)	4344725	41	34	39	8	10	5	9	9	8	0	0.0845	0.994	1.000
25	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3), IFNG(2), IL12A(3), IL12B(2), IL18(1)	1747883	11	10	11	4	2	3	1	4	1	0	0.734	0.996	1.000
26	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(7), CBS(9), CTH(3), MUT(7)	2864191	29	27	28	6	6	3	3	2	15	0	0.316	0.998	1.000
27	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(6), PAPSS1(6), PAPSS2(6), SULT1A2(8), SULT1E1(3), SULT2A1(4), SUOX(7)	3588654	40	32	40	7	12	9	4	8	7	0	0.0587	0.998	1.000
28	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(12), CD4(11), HLA-DRA(7), HLA-DRB1(1), IL1B(4), IL4(4), IL5RA(8)	3135061	48	38	42	12	11	4	7	10	16	0	0.307	0.998	1.000
29	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(4), CD28(1), CD3E(2), CD4(11)	1887793	18	18	13	8	2	1	4	3	8	0	0.966	0.998	1.000
30	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(8), ARHGAP5(26), ARHGDIB(1), CASP1(3), CASP10(8), CASP3(2), CASP9(3), GZMB(2), JUN(5), PRF1(13)	6882298	71	49	67	10	18	10	5	15	20	3	0.0240	0.999	1.000
31	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(4), HLCS(6), SPCS1(2), SPCS3(3)	1799998	15	13	15	5	4	1	0	9	1	0	0.617	0.999	1.000
32	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(11), CD80(5), HLA-DRA(7), HLA-DRB1(1), IL10(2), IL4(4)	2331569	31	30	25	9	11	2	2	6	10	0	0.614	0.999	1.000
33	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(4), GBA(12), GGT1(9), SHMT1(2), SHMT2(11)	3200743	38	31	36	9	12	3	6	5	12	0	0.177	0.999	1.000
34	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(10), CCNE1(5), CDC34(2), CDK2(4), CUL1(24), E2F1(4), RB1(14), SKP2(6), TFDP1(5)	5022983	74	57	74	17	12	11	16	14	21	0	0.0497	0.999	1.000
35	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(7), ACADS(4), ACAT1(6), ECHS1(2), HADHA(5)	3169892	27	22	25	5	6	5	4	4	8	0	0.129	0.999	1.000
36	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), MIOX(6), UGDH(8)	4975235	71	47	62	15	15	8	11	12	25	0	0.109	0.999	1.000
37	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(4), FOS(1), JUN(5), KEAP1(11), MAFF(1), MAPK1(3), MAPK14(2), MAPK8(6), NFE2L2(2), PRKCA(8)	5186728	43	35	42	9	11	11	5	6	10	0	0.0369	1.000	1.000
38	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCL11(1), CCR3(12), CFL1(1), GNAQ(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), LIMK1(6), MAPK1(3), MAPK3(3), MYL2(9), NOX1(7), PIK3C2G(14), PLCB1(21), PPP1R12B(16), PRKCA(8), PTK2(11), RAF1(9), ROCK2(16)	14312770	184	99	175	27	64	20	18	36	46	0	9.03e-05	1.000	1.000
39	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(8), AASDHPPT(1), AASS(10), KARS(7)	2770822	26	20	26	6	6	5	5	6	4	0	0.258	1.000	1.000
40	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25A(5), CDC25B(6), CDC25C(11), CSK(8), GRB2(4), PRKCA(8), PTPRA(15), SRC(5)	5410644	65	46	62	12	20	5	9	11	19	1	0.0426	1.000	1.000
41	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(9), SHMT1(2), SHMT2(11)	2413569	23	20	21	8	7	3	2	1	10	0	0.502	1.000	1.000
42	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(6), ACAT2(5), ACYP1(1), ACYP2(3), ECHS1(2), EHHADH(4), GCDH(7), HADHA(5), SDHB(4), SDS(4)	4575240	41	30	37	8	7	8	8	3	15	0	0.111	1.000	1.000
43	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(11), CD8A(4), CSF1(5), CSF3(1), EPO(3), IL11(3), IL3(1), IL4(4), IL7(2)	3565277	34	30	28	9	9	4	4	6	11	0	0.487	1.000	1.000
44	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), NFYC(3), RB1(14), SP1(5), SP3(5)	3917350	28	24	28	5	6	4	6	4	8	0	0.110	1.000	1.000
45	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8)	3311151	25	20	24	5	4	0	6	9	6	0	0.200	1.000	1.000
46	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(10), F13A1(19), F2(11), F2R(6), FGA(12), FGB(6), FGG(5), PLAT(7), PLG(18), SERPINB2(9), SERPINE1(3)	7868198	106	73	102	24	33	10	14	29	20	0	0.0415	1.000	1.000
47	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAA2(9), ACAT1(6), ACAT2(5), ECHS1(2), EHHADH(4), HADHA(5), HADHB(6), SDS(4)	4902371	44	30	42	9	6	9	11	3	15	0	0.0712	1.000	1.000
48	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(1), CD3E(2), IFNG(2), IL2RA(2), IL4(4), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR3(9), TOB1(1), TOB2(6)	5522973	56	50	54	14	15	3	11	10	17	0	0.296	1.000	1.000
49	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(11), GLS2(8), GLUD1(4), GLUD2(13)	2669437	36	27	35	9	8	3	5	12	8	0	0.312	1.000	1.000
50	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(5), DAB1(13), FYN(9), LRP8(5), RELN(52), VLDLR(7)	8227346	94	62	93	19	23	18	15	23	15	0	0.00432	1.000	1.000
51	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(4), DFFA(4), DFFB(3), GZMB(2), HMGB1(3), HMGB2(3), TOP2A(15), TOP2B(11)	5217700	47	35	38	8	6	6	5	14	16	0	0.333	1.000	1.000
52	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(8), CYP2C9(1)	1190402	9	7	9	5	5	1	0	2	1	0	0.935	1.000	1.000
53	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	16	IL18(1), ITGB1(11), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), LAT(3), MAPK3(3), PAK1(5), PIK3R1(12), PTK2B(16), PTPN6(6), RAC1(1), SYK(9), VAV1(13)	8600178	98	69	92	18	23	14	12	20	28	1	0.0143	1.000	1.000
54	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(6), CHRNA1(7), SNAP25(2), STX1A(4), VAMP2(1)	1912567	20	19	20	6	7	1	2	5	5	0	0.569	1.000	1.000
55	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(6), COASY(4), DPYD(20), DPYS(8), ENPP1(7), ENPP3(12), PANK1(11), PANK2(6), PANK3(2), PANK4(5), PPCS(2), UPB1(6)	8177249	89	57	85	15	17	9	16	23	24	0	0.00379	1.000	1.000
56	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	5	ADAM17(9), NRG2(9), NRG3(24), PRKCA(8), PSEN1(5)	3691614	55	43	53	18	15	8	9	10	13	0	0.501	1.000	1.000
57	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CCNH(3), CDC25A(5), CDC25B(6), CDC25C(11), MNAT1(3), SHH(6), XPO1(13)	5072964	50	36	46	11	12	10	4	11	12	1	0.165	1.000	1.000
58	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(6), COQ5(1), COQ6(4), COQ7(4), NDUFA12(2), NDUFA13(2), NDUFB11(2)	2338753	21	19	21	8	6	2	3	3	7	0	0.754	1.000	1.000
59	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(49), CDC25A(5), CDC25B(6), CDC25C(11), CHEK1(6), MYT1(22), WEE1(6), YWHAH(3)	8091041	108	68	101	22	25	14	10	24	31	4	0.0944	1.000	1.000
60	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(9), MAX(3), MYC(6), SP1(5), SP3(5), WT1(5)	3656904	33	27	31	9	11	6	3	5	8	0	0.197	1.000	1.000
61	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(5), IL1B(4), MST1R(13), TNF(3)	3835744	26	22	25	4	3	4	0	7	12	0	0.153	1.000	1.000
62	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(12), PLCB1(21), PLCG1(22), PRKCA(8), VAV1(13)	6249070	79	54	74	15	25	9	10	13	21	1	0.0240	1.000	1.000
63	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(38), GNB1(2), GNGT1(3), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8)	5665591	93	65	86	20	43	8	4	16	22	0	0.0843	1.000	1.000
64	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(33), GNA12(1), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAR2A(3), PRKAR2B(9)	5922815	66	51	62	14	13	8	10	11	22	2	0.170	1.000	1.000
65	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6)	4671816	67	43	58	20	15	6	8	12	26	0	0.558	1.000	1.000
66	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6)	4671816	67	43	58	20	15	6	8	12	26	0	0.558	1.000	1.000
67	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8)	7370870	83	54	78	20	23	12	13	19	16	0	0.0802	1.000	1.000
68	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(33), AKT1(3), ATM(49), BAX(1), CDKN1A(5), CPB2(10), CSNK1A1(5), CSNK1D(4), FHL2(2), HIC1(10), HIF1A(5), HSPA1A(4), IGFBP3(5), MAPK8(6), MDM2(8), NFKBIB(8), NQO1(3)	11692194	161	94	153	30	38	26	16	31	46	4	0.00307	1.000	1.000
69	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(3), BCAR1(10), CDKN1B(1), GRB2(4), ILK(9), ITGB1(11), MAPK1(3), MAPK3(3), PDK2(1), PDPK1(1), PIK3R1(12), PTK2(11), SHC1(7), SOS1(9)	9522585	85	60	81	14	23	6	12	19	24	1	0.0152	1.000	1.000
70	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(1), RANBP2(36), RANGAP1(14)	4949325	53	41	52	15	8	9	12	11	11	2	0.251	1.000	1.000
71	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(9), ECHS1(2), HADH(2), HADHA(5), HADHB(6), HSD17B4(7), MECR(4), PPT1(5), PPT2(3)	4964482	43	27	42	8	8	8	12	3	12	0	0.0162	1.000	1.000
72	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	9	ACACA(28), CPT1A(14), LEP(3), LEPR(14), PRKAA1(7), PRKAA2(10), PRKAB2(4), PRKAG1(5), PRKAG2(7)	8169533	92	57	90	18	28	8	10	24	21	1	0.0558	1.000	1.000
73	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(5), CCND1(2), CDK2(4), CDK4(2), CDKN1A(5), CDKN1B(1), CFL1(1), E2F1(4), E2F2(5), MDM2(8), NXT1(3), PRB1(3)	4116209	43	31	40	9	13	10	6	4	9	1	0.0926	1.000	1.000
74	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(49), CDC25A(5), CDC25B(6), CDC25C(11), CDK2(4), CDK4(2), CHEK1(6), MYT1(22), RB1(14), WEE1(6), YWHAH(3)	9859652	128	78	121	23	25	18	15	28	38	4	0.0277	1.000	1.000
75	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(16), GBA(12), LPO(11), MPO(9), PRDX6(2), TPO(27)	4887943	77	63	74	19	29	9	8	20	10	1	0.118	1.000	1.000
76	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(11), CD44(8), CSF1(5), FCGR3A(5), IL1B(4), IL6R(3), SELL(6), SPN(4), TGFB1(3), TGFB2(9), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(7), TNFSF8(4)	7689174	81	57	78	22	22	7	8	19	24	1	0.183	1.000	1.000
77	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(1), HLA-DRA(7), HLA-DRB1(1), IFNG(2), IFNGR1(10), IFNGR2(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18(1), IL18R1(6), IL2RA(2), IL4(4), IL4R(7)	7024741	67	48	67	19	16	10	11	15	15	0	0.179	1.000	1.000
78	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(6), BCAT2(9), COASY(4), DPYD(20), DPYS(8), ENPP1(7), ENPP3(12), ILVBL(8), PANK1(11), PANK2(6), PANK3(2), PANK4(5), PPCDC(1), PPCS(2), UPB1(6), VNN1(4)	10155213	111	67	107	20	28	10	18	29	26	0	0.00241	1.000	1.000
79	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(9), ACP2(5), ACP5(3), ACPP(5), ACPT(6), ENPP1(7), ENPP3(12), FLAD1(5), RFK(2), TYR(15)	5693618	69	50	61	14	11	10	14	15	19	0	0.0859	1.000	1.000
80	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	CUZD1(4), FOS(1), HRAS(1), JUN(5), MAPK1(3), MAPK3(3), MYC(6), NFKB1(8), NFKBIA(1), PLCB1(21), PRKCA(8), RAF1(9), RELA(7), TNF(3)	8665421	80	55	76	15	21	11	8	18	22	0	0.0179	1.000	1.000
81	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(4), CASP3(2), CFL1(1), CFLAR(1), PDE6D(1)	1587018	9	8	9	5	2	4	1	1	1	0	0.802	1.000	1.000
82	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(5)	1539314	10	10	10	9	4	2	1	2	1	0	0.972	1.000	1.000
83	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(8), CYSLTR2(1), GPR161(12), GPR171(2), GPR18(3), GPR39(10), GPR45(17), GPR65(1), GPR68(4), GPR75(5)	5775854	63	48	56	17	26	4	8	9	16	0	0.204	1.000	1.000
84	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(28), ACACB(40), FASN(27), MCAT(3), OLAH(1), OXSM(6)	9197344	105	64	100	22	31	14	15	24	20	1	0.0107	1.000	1.000
85	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(14), APOBEC1(6), APOBEC2(3), APOBEC3B(5), APOBEC3C(1), APOBEC3F(2), APOBEC3G(3), APOBEC4(2)	4299379	36	25	36	7	11	7	5	6	7	0	0.119	1.000	1.000
86	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(5), ANKRD1(5), ATF3(2), CYR61(2), DUSP14(3), EIF4E(2), EIF4EBP1(4), HBEGF(2), IFNG(2), IFRD1(10), IL18(1), IL1A(2), IL1R1(4), JUND(2), MYOG(4), NR4A3(6), WDR1(4)	6261577	60	42	56	14	21	6	5	10	18	0	0.135	1.000	1.000
87	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(8), NFKBIA(1), PLCB1(21), PRKCA(8), RELA(7)	4828342	48	37	46	11	13	6	4	12	13	0	0.148	1.000	1.000
88	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(2), EHHADH(4), HADHA(5), SDS(4)	2837256	18	15	17	6	4	3	3	2	6	0	0.453	1.000	1.000
89	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6)	7746845	86	54	76	19	18	7	14	19	28	0	0.0904	1.000	1.000
90	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(8), AKT1(3), ANXA1(6), CALM1(2), CALM2(3), CALM3(1), GNAS(38), GNB1(2), GNGT1(3), NFKB1(8), NOS3(15), NPPA(2), NR3C1(9), PIK3R1(12), RELA(7), SYT1(5)	9212722	124	81	114	24	45	9	12	29	28	1	0.0263	1.000	1.000
91	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(4), CREBBP(46), DFFA(4), DFFB(3), GZMA(4), GZMB(2), HMGB2(3), PRF1(13), SET(7)	6199182	87	60	83	22	27	10	13	18	19	0	0.101	1.000	1.000
92	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(7), F13B(17), HSD17B1(4), HSD17B2(3), HSD17B3(2), HSD17B4(7), HSD17B7(5), HSD3B1(4), HSD3B2(2)	4751597	51	40	51	14	7	10	10	15	9	0	0.206	1.000	1.000
93	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(46), EP300(27), ESR1(8), MAPK1(3), MAPK3(3), PELP1(8), SRC(5)	8597548	100	68	95	24	36	10	15	16	23	0	0.0488	1.000	1.000
94	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(3), CALM3(1), CCL2(1), CCR5(4), FOS(1), GNAQ(3), JUN(5), MAPK14(2), MAPK8(6), PLCG1(22), PRKCA(8), PTK2B(16), SYT1(5)	8104830	79	59	75	17	31	11	9	10	18	0	0.0133	1.000	1.000
95	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), ESRRA(2), HDAC5(13), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), PPARA(7), PPP3CA(13), PPP3CB(6), PPP3CC(6), SLC2A4(5), SYT1(5), YWHAH(3)	11828647	130	84	126	28	33	17	17	28	35	0	0.00542	1.000	1.000
96	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(5), CPS1(24), GLS(11), GLUD1(4), GOT1(3)	4578154	49	39	48	12	15	4	6	16	8	0	0.202	1.000	1.000
97	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(8), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CASP3(2), CASP6(1), CASP7(4), CASP9(3), DFFA(4), DFFB(3), DIABLO(1)	7195897	55	39	53	10	12	11	7	14	11	0	0.0657	1.000	1.000
98	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2)	8215011	95	67	92	21	23	14	15	18	25	0	0.0643	1.000	1.000
99	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2)	8215011	95	67	92	21	23	14	15	18	25	0	0.0643	1.000	1.000
100	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2)	8215011	95	67	92	21	23	14	15	18	25	0	0.0643	1.000	1.000
101	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(6), GNAQ(3), GNB1(2), GNGT1(3), HTR2C(10), PLCB1(21), TUB(7)	4198897	52	39	50	13	14	5	6	14	13	0	0.270	1.000	1.000
102	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(8), ATM(49), BAX(1), BCL2(4), CCND1(2), CCNE1(5), CDK2(4), CDK4(2), CDKN1A(5), E2F1(4), MDM2(8), PCNA(2), RB1(14), TIMP3(10)	10169478	118	73	109	22	23	18	16	22	34	5	0.0362	1.000	1.000
103	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(8), CHPT1(4), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(5), PCYT1A(9), PCYT1B(6), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), WBSCR22(5)	8225990	90	56	85	17	20	14	13	18	24	1	0.0136	1.000	1.000
104	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), FDXR(10), SHMT1(2)	8773077	105	69	102	23	27	16	18	18	26	0	0.0375	1.000	1.000
105	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(3), DAG1(13), GNAQ(3), ITPKA(2), ITPKB(14)	3549388	39	29	38	12	15	1	7	8	8	0	0.416	1.000	1.000
106	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), PRKCE(14)	4620560	84	57	82	29	20	6	17	31	10	0	0.516	1.000	1.000
107	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(3), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(6), NDUFV1(6), NDUFV2(1)	4057689	36	28	35	8	6	7	6	8	9	0	0.274	1.000	1.000
108	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(4), LDLR(12), NR0B2(3), NR1H3(5), NR1H4(6), RXRA(13)	3196091	43	32	42	14	21	3	3	6	10	0	0.316	1.000	1.000
109	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(8), ATM(49), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), CASP3(2), CASP6(1), CASP7(4), CASP9(3), EIF2S1(2), PRKCA(8), PTK2(11), PXN(6), STAT1(11), TLN1(28)	15584479	148	84	141	26	45	25	15	23	37	3	0.00104	1.000	1.000
110	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(53), AXIN1(15), CREBBP(46), CTNNB1(27), DVL1(8), EP300(27), FZD1(11), GSK3B(6), HDAC1(9), LDB1(4), LEF1(5), PITX2(5), TRRAP(62)	19160070	278	139	256	58	87	24	34	51	77	5	0.000325	1.000	1.000
111	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(8), BAD(4), BAK1(4), BAX(1), BCL10(2), BCL2(4), BCL2L1(1), BCL2L11(4), BID(2), CASP9(3)	5872352	33	25	33	6	11	9	3	7	3	0	0.0692	1.000	1.000
112	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(2), GLS(11), GLUD1(4), OAT(3), PRODH(1)	3232073	25	19	24	8	6	4	2	7	6	0	0.463	1.000	1.000
113	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(22), PRKCA(8), PTK2B(16)	3956875	51	40	47	12	26	6	3	4	12	0	0.0644	1.000	1.000
114	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(7), GOSR1(2), GOSR2(3), SNAP25(2), SNAP29(2), STX10(4), STX11(7), STX12(3), STX16(10), STX17(2), STX18(2), STX19(4), STX2(6), STX3(2), STX4(4), STX5(1), STX6(6), STX7(4), STX8(4), TSNARE1(8), USE1(5), VAMP1(1), VAMP2(1), VAMP4(1), VAMP5(1), VAMP7(2), VTI1A(3), VTI1B(3), YKT6(4)	9778185	105	64	102	19	33	18	14	15	25	0	0.00468	1.000	1.000
115	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(9), ACP2(5), ACP5(3), ACP6(3), ACPP(5), ACPT(6), ENPP1(7), ENPP3(12), FLAD1(5), LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), PHPT1(2), RFK(2), TYR(15)	8825734	102	68	93	23	19	14	19	20	30	0	0.0625	1.000	1.000
116	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGB1(11), ITGB2(12), SELE(6), SELL(6)	7097884	85	54	80	26	26	5	12	20	22	0	0.179	1.000	1.000
117	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(5), MAPK14(2), MAPK8(6), NFKB1(8), RELA(7), TNFRSF13B(7), TNFRSF13C(4), TNFRSF17(1), TNFSF13(6), TNFSF13B(4), TRAF2(4), TRAF3(7), TRAF5(4), TRAF6(6)	8508821	71	53	70	14	14	16	5	15	20	1	0.0686	1.000	1.000
118	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT5(4), FUT8(9), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7)	4623405	53	47	52	14	22	9	5	8	9	0	0.246	1.000	1.000
119	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(11), BMPR1A(12), BMPR1B(9), BMPR2(21)	3675816	53	42	51	13	8	3	9	7	24	2	0.438	1.000	1.000
120	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(6), CDO1(3), CSAD(7), GAD1(8), GAD2(15), GGT1(9)	3362127	48	38	46	17	16	6	5	8	13	0	0.433	1.000	1.000
121	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), NAT1(2), NAT2(6), XDH(23)	4685062	64	54	63	19	16	12	10	18	8	0	0.274	1.000	1.000
122	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(5), BIRC3(10), FADD(3), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4)	4207950	39	34	38	13	8	7	3	6	14	1	0.649	1.000	1.000
123	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(8), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(3), ST8SIA1(12)	3309705	47	41	45	16	21	2	7	10	7	0	0.465	1.000	1.000
124	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	10	APC(53), CREBBP(46), EP300(27), MAP3K7(11), MAPK3(3), SKIL(7), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8)	12924665	176	104	163	36	43	16	25	28	60	4	0.0224	1.000	1.000
125	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(4), CREM(6), FOS(1), JUN(5), MAPK3(3), OPRK1(17), POLR2A(24), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	7550521	99	68	94	26	24	17	15	17	26	0	0.0900	1.000	1.000
126	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(3), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(4), EIF4G1(25), EIF4G3(22), GHR(9), IRS1(27), MAPK1(3), MAPK14(2), MAPK3(3), MKNK1(5), PABPC1(10), PDK2(1), PDPK1(1), PIK3R1(12), PRKCA(8), RPS6KB1(6)	14740554	152	86	143	28	33	21	22	25	48	3	0.0119	1.000	1.000
127	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(4), CAT(6), EPX(16), LPO(11), MPO(9), MTHFR(10), PRDX6(2), SHMT1(2), SHMT2(11), TPO(27)	6785949	98	73	94	25	34	11	7	22	23	1	0.119	1.000	1.000
128	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(4), IFNG(2), IFNGR1(10), JAK1(19), JAK2(12), PLA2G2A(2), PTPRU(26), REG1A(4), STAT1(11)	6722624	90	62	86	25	25	16	9	11	26	3	0.255	1.000	1.000
129	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(8), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), WBSCR22(5)	8792934	90	55	84	19	21	12	13	17	26	1	0.0326	1.000	1.000
130	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(8), ASPH(9), COPS5(3), CREB1(4), EDN1(4), EP300(27), EPO(3), HIF1A(5), JUN(5), LDHA(7), NOS3(15), P4HB(3), VHL(2)	9947001	95	61	88	21	23	13	15	17	27	0	0.0674	1.000	1.000
131	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(8), IFNB1(3), JAK1(19), PTPRU(26), REG1A(4), STAT1(11), STAT2(6), TYK2(12)	7312970	89	60	85	24	30	10	8	10	29	2	0.277	1.000	1.000
132	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(7), PRKCA(8), TGM2(12)	2905955	32	27	31	11	17	4	0	6	5	0	0.340	1.000	1.000
133	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(1), CD3E(2), CD80(5), CTLA4(4), GRB2(4), HLA-DRA(7), HLA-DRB1(1), ICOS(4), ITK(5), LCK(4), PIK3R1(12), PTPN11(8)	5828627	57	49	53	14	15	5	10	14	12	1	0.223	1.000	1.000
134	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(7), ACO2(11), FH(4), IDH1(4), IDH2(4), MDH1(3), SDHB(4), SUCLA2(3)	5225598	40	29	39	11	13	7	4	5	11	0	0.379	1.000	1.000
135	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(4), CD3E(2), CD4(11), CD58(7), CD8A(4), CSF3(1), IL3(1), KITLG(4)	3626395	38	32	32	13	4	4	7	7	16	0	0.750	1.000	1.000
136	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(4), GRB2(4), HRAS(1), PTK2B(16), SHC1(7), SOS1(9), SRC(5)	5184522	46	37	45	12	15	6	4	12	9	0	0.255	1.000	1.000
137	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(6), NR1I3(3), PTGS1(13), PTGS2(7)	3139721	34	26	34	10	13	4	4	6	6	1	0.357	1.000	1.000
138	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(12), MBTPS1(12), MBTPS2(7), SCAP(14), SREBF1(15), SREBF2(15)	6929133	77	50	75	19	25	6	10	13	23	0	0.124	1.000	1.000
139	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(11), ACO1(7), ACO2(11), ACSS1(16), ACSS2(12), FH(4), IDH1(4), IDH2(4), MDH1(3), SUCLA2(3)	7805636	75	49	73	18	20	15	7	12	21	0	0.129	1.000	1.000
140	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ESCO1(10), ESCO2(10), NAT6(4), PNPLA3(4), SH3GLB1(3)	9727397	50	39	48	7	12	4	5	8	21	0	0.0701	1.000	1.000
141	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(14), AMT(4), ATIC(5), ATP6V0C(1), GART(10), MTHFD1(7), MTHFD1L(8), MTHFD2(1), MTHFR(10), MTHFS(3), MTR(19), SHMT1(2), SHMT2(11), TYMS(1)	10488007	96	62	92	23	25	14	14	17	25	1	0.0210	1.000	1.000
142	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(14), PDXK(4), PDXP(2), PNPO(2), PSAT1(7)	2838566	29	23	29	11	4	5	4	8	6	2	0.626	1.000	1.000
143	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(1), FOSL2(10), IFNAR1(8), IFNAR2(4), IFNB1(3), MAPK8(6), NFKB1(8), RELA(7), TNFRSF11A(4), TNFSF11(5), TRAF6(6)	6488091	63	50	63	19	15	11	7	15	15	0	0.339	1.000	1.000
144	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	18	AP2A1(14), AP2M1(8), BIN1(7), CALM1(2), CALM2(3), CALM3(1), DNM1(6), EPN1(8), EPS15(2), NME2(3), PICALM(4), PPP3CA(13), PPP3CB(6), PPP3CC(6), SYNJ1(11), SYNJ2(20), SYT1(5)	11913157	119	66	111	20	36	11	13	25	34	0	0.000623	1.000	1.000
145	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), KLK2(1), MAPK3(3), MAPK8(6), NGFR(7), PIK3R1(12), PLCG1(22), RAF1(9), SHC1(7), SOS1(9)	9469653	96	61	92	22	31	10	12	19	23	1	0.0500	1.000	1.000
146	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(10), CRK(1), GNAI1(3), GNAQ(3), GNB1(2), GNGT1(3), HRAS(1), MAPK1(3), MAPK3(3), NFKB1(8), PIK3C2G(14), PIK3R1(12), PLCG1(22), PRKCA(8), PTK2(11), PTK2B(16), PXN(6), RAF1(9), RELA(7)	14421271	142	81	136	28	46	15	17	18	45	1	0.00316	1.000	1.000
147	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(5), GSS(2), NFKB1(8), NOX1(7), RELA(7), TNF(3), XDH(23)	5813886	55	40	55	15	12	12	6	14	11	0	0.239	1.000	1.000
148	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF3(1), EPO(3), FLT3(12), IGF1(2), IL11(3), IL1A(2), IL3(1), KITLG(4), TGFB1(3), TGFB2(9), TGFB3(9)	4856420	50	39	47	17	15	7	5	12	11	0	0.533	1.000	1.000
149	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(8), IFNAR2(4), IFNB1(3), JAK1(19), STAT1(11), STAT2(6), TYK2(12)	6345965	64	44	61	18	16	7	9	9	21	2	0.472	1.000	1.000
150	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), SDS(4)	7113853	82	46	72	26	18	9	10	14	31	0	0.532	1.000	1.000
151	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(10), IFNGR2(2), JAK1(19), JAK2(12), STAT1(11)	4820354	56	41	53	18	9	11	7	8	18	3	0.681	1.000	1.000
152	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(13), PARK2(13), SNCA(1), SNCAIP(16), UBE2E2(1), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1)	3773034	51	42	49	19	15	8	8	12	8	0	0.468	1.000	1.000
153	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(4), BLVRB(1), HMOX1(7), IL10(2), IL10RA(5), IL10RB(2), IL1A(2), JAK1(19), STAT1(11), STAT3(7), STAT5A(10), TNF(3)	7151718	73	55	70	21	15	9	7	18	22	2	0.460	1.000	1.000
154	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(5), BRAF(18), CAMP(3), CREB1(4), CREB5(7), MAPK1(3), RAF1(9), SNX13(7), SRC(5), TERF2IP(5)	6555879	70	51	63	18	18	10	8	13	21	0	0.296	1.000	1.000
155	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(6), CHST11(4), CHST12(6), CHST13(5), PAPSS1(6), PAPSS2(6), SULT1A1(9), SULT1A2(8), SULT1E1(3), SULT2A1(4), SULT2B1(1), SUOX(7)	5409524	65	46	64	18	26	10	6	12	11	0	0.121	1.000	1.000
156	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(8), BIRC2(7), BIRC3(10), CASP10(8), CASP3(2), CASP7(4), CASP9(3), DFFA(4), DFFB(3), GZMB(2), PRF1(13), SCAP(14), SREBF1(15), SREBF2(15)	9941311	108	66	104	22	33	12	13	25	25	0	0.0363	1.000	1.000
157	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(9), ALOX15(10), ALOX15B(4), ALOX5(11), ALOX5AP(2), DPEP1(3), GGT1(9), LTA4H(4), PLA2G2A(2), PLA2G6(8), PTGDS(1), PTGES(1), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7)	8782231	99	64	98	25	38	10	10	20	19	2	0.0321	1.000	1.000
158	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3E(2), GZMB(2), ICAM1(4), ITGAL(22), ITGB2(12), PRF1(13)	4533595	55	45	53	20	20	5	6	9	15	0	0.422	1.000	1.000
159	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(21), GNAS(38), GNB1(2), GNGT1(3), PRKACA(6), PRKAR1A(4)	3908004	74	51	70	21	36	5	3	15	14	1	0.408	1.000	1.000
160	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(3), IL12B(2), IL13(4), IL15(1), IL16(18), IL18(1), IL1A(2), IL3(1), IL4(4), LTA(4), TNF(3)	5828745	51	41	51	18	11	7	7	14	12	0	0.548	1.000	1.000
161	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMC2(5), PSMC3(9), PSMD1(10), PSMD11(4), PSMD12(5), PSMD13(2), PSMD2(17), PSMD6(5)	9386180	94	56	94	18	25	13	18	18	20	0	0.0226	1.000	1.000
162	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(49), ATR(28), CDC25C(11), CHEK1(6), CHEK2(10), YWHAH(3)	8909257	107	65	99	20	21	10	13	21	38	4	0.206	1.000	1.000
163	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(11), CSF1(5), CSF3(1), HLA-DRA(7), HLA-DRB1(1), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL11(3), IL12A(3), IL12B(2), IL13(4), IL15(1), IL1A(2), IL3(1), IL4(4), IL7(2), LTA(4), PDGFA(2), TGFB1(3), TGFB2(9), TGFB3(9), TNF(3)	7800711	85	63	77	26	23	12	10	17	23	0	0.442	1.000	1.000
164	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(6), CYB5R3(4), GCK(9), GFPT1(7), GNE(11), GNPDA1(4), GNPDA2(7), HEXA(2), HEXB(3), HK1(17), HK2(12), HK3(11), PGM3(13), RENBP(3), UAP1(5)	9926324	114	72	110	28	38	19	17	26	14	0	0.0196	1.000	1.000
165	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(4), ATP6V0C(1), CAT(6), EPX(16), LPO(11), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), SHMT1(2), SHMT2(11), TPO(27)	6889067	92	71	88	27	29	11	8	21	22	1	0.255	1.000	1.000
166	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AADAC(6), AOC2(10), AOC3(13), DDHD1(13), ESCO1(10), ESCO2(10), LIPA(3), NAT6(4), PLA1A(3), PNPLA3(4), PPME1(1), PRDX6(2), SH3GLB1(3)	14330315	82	54	76	10	15	7	8	16	36	0	0.0343	1.000	1.000
167	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	APC(53), AXIN1(15), BTRC(9), CCND1(2), CREBBP(46), CSNK1A1(5), CSNK1D(4), CSNK2A1(5), CTBP1(5), CTNNB1(27), DVL1(8), FZD1(11), GSK3B(6), HDAC1(9), MAP3K7(11), MYC(6), PPARD(8), PPP2CA(4), TLE1(13), WIF1(3)	16413972	250	131	226	59	68	28	24	42	83	5	0.0184	1.000	1.000
168	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(4), CASP9(3), CHUK(5), GH1(2), GHR(9), NFKB1(8), NFKBIA(1), PDPK1(1), PIK3R1(12), PPP2CA(4), RELA(7), YWHAH(3)	6965765	62	41	61	16	11	10	11	15	14	1	0.221	1.000	1.000
169	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(9), HK1(17), HK2(12), HK3(11), IMPA1(7), PGM1(3), PGM3(13), TGDS(5)	5996018	77	56	74	25	24	14	13	20	6	0	0.207	1.000	1.000
170	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(5), DNAJC3(3), EIF2S1(2), EIF2S2(3), NFKB1(8), NFKBIA(1), RELA(7)	5246569	29	20	29	8	5	4	3	9	8	0	0.546	1.000	1.000
171	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(7), FDFT1(3), FDPS(12), HMGCR(7), IDI1(2), LSS(14), MVD(2), NQO1(3), NQO2(3), PMVK(1), SQLE(9), VKORC1(1)	5964954	64	38	62	18	19	8	6	15	16	0	0.266	1.000	1.000
172	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), GRB2(4), HRAS(1), KLK2(1), NTRK1(9), PIK3R1(12), PLCG1(22), PRKCA(8), SHC1(7), SOS1(9)	7853906	76	54	73	18	25	8	10	15	17	1	0.109	1.000	1.000
173	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(8), CDKN1A(5), EPO(3), EPOR(3), GRIN1(11), HIF1A(5), JAK2(12), NFKB1(8), NFKBIA(1), RELA(7), SOD2(2)	7412793	65	43	64	17	14	16	7	8	19	1	0.158	1.000	1.000
174	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(9), HK1(17), HK2(12), HK3(11), IMPA1(7), IMPA2(2), ISYNA1(4), PGM1(3), PGM3(13), TGDS(5)	6826018	83	60	79	27	28	14	13	22	6	0	0.166	1.000	1.000
175	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CAMKK1(5), CAMKK2(2), CREB1(4), SYT1(5)	6759791	65	47	64	21	16	9	14	10	16	0	0.324	1.000	1.000
176	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(3), CDK5R1(5), EGR1(12), HRAS(1), KLK2(1), MAP2K2(3), MAPK1(3), MAPK3(3), NGFR(7), RAF1(9)	4337014	47	34	44	17	18	6	6	6	11	0	0.467	1.000	1.000
177	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(26), ARHGEF1(12), GNA12(1), GNA13(7), GNAQ(3), GNB1(2), GNGT1(3), MYL2(9), MYLK(25), PLCB1(21), PPP1R12B(16), PRKCA(8), ROCK1(20)	12130833	153	93	145	31	40	19	17	31	40	6	0.0157	1.000	1.000
178	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8)	10253111	101	60	95	28	32	13	13	21	22	0	0.203	1.000	1.000
179	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), AKT1(3), AKT2(10), AKT3(8), ARHGAP5(26), BAD(4), BCAR1(10), BCL2(4), BIRC2(7), BIRC3(10), BRAF(18), CAPN2(10), CAV1(5), CAV2(1), CAV3(2), CCND1(2), CCND2(2), CCND3(1), CDC42(3), CHAD(7), COL11A1(47), COL11A2(18), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), COMP(6), CRK(1), CRKL(2), CTNNB1(27), DIAPH1(14), DOCK1(20), EGF(11), EGFR(19), ELK1(4), ERBB2(23), FARP2(6), FIGF(5), FLNA(28), FLNB(33), FLNC(38), FLT1(19), FN1(33), FYN(9), GRB2(4), GSK3B(6), HRAS(1), IBSP(4), IGF1(2), IGF1R(20), ILK(9), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAV(18), ITGB1(11), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), JUN(5), KDR(17), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MET(10), MYL2(9), MYL7(3), MYL9(2), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PARVA(2), PARVB(5), PARVG(5), PDGFA(2), PDGFB(6), PDGFC(8), PDGFD(10), PDGFRA(13), PDGFRB(12), PDPK1(1), PGF(3), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP5K1C(14), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PRKCA(8), PRKCG(17), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF1(11), RELN(52), ROCK1(20), ROCK2(16), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SPP1(4), SRC(5), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TLN1(28), TLN2(32), TNC(27), TNN(31), TNR(26), TNXB(68), VASP(2), VAV1(13), VAV2(13), VAV3(14), VCL(11), VEGFB(2), VEGFC(12), VTN(10), VWF(38), ZYX(7)	214060704	2532	330	2436	844	810	349	281	532	535	25	0.0189	1.000	1.000
180	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	162	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY7(18), ADCY8(37), ADCY9(17), ADORA2A(2), ADORA2B(2), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), ATP2A1(12), ATP2A2(4), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(23), ATP2B4(16), AVPR1A(17), AVPR1B(3), BDKRB1(4), BDKRB2(3), BST1(3), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1F(14), CACNA1G(27), CACNA1H(40), CACNA1I(26), CACNA1S(26), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CCKAR(7), CCKBR(16), CD38(5), CHRM1(6), CHRM2(19), CHRM3(12), CHRM5(4), CHRNA7(6), CYSLTR1(8), CYSLTR2(1), DRD1(4), EDNRA(4), EGFR(19), ERBB2(23), F2R(6), GNA11(6), GNA14(5), GNA15(4), GNAL(3), GNAQ(3), GNAS(38), GRIN1(11), GRIN2A(20), GRIN2C(10), GRIN2D(10), GRM1(43), GRPR(6), HRH1(5), HRH2(6), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), LTB4R2(6), MYLK(25), MYLK2(8), NOS1(39), NOS3(15), NTSR1(10), OXTR(8), P2RX2(7), P2RX3(7), P2RX4(7), P2RX5(7), P2RX7(2), PDE1A(7), PDE1B(5), PDE1C(14), PDGFRA(13), PDGFRB(12), PHKA1(10), PHKA2(15), PHKB(7), PHKG1(2), PHKG2(11), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PPID(5), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PTAFR(4), PTGER3(8), PTGFR(5), PTK2B(16), RYR1(68), RYR2(106), RYR3(81), SLC25A4(3), SLC25A5(3), SLC25A6(5), SLC8A1(19), SLC8A2(18), SLC8A3(12), SPHK1(10), SPHK2(8), TACR1(4), TACR2(2), TACR3(15), TBXA2R(9), TNNC1(2), TNNC2(1), TRHR(7), TRPC1(11), VDAC1(3), VDAC2(2), VDAC3(7)	151293684	2114	310	2024	696	794	249	273	408	379	11	0.000288	1.000	1.000
181	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	230	ADCYAP1R1(8), ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), ADRA1A(19), ADRA1B(5), ADRA2A(9), ADRA2B(10), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), AGTR2(4), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), C5AR1(6), CALCR(6), CALCRL(10), CCKAR(7), CCKBR(16), CGA(1), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CNR1(13), CNR2(3), CRHR1(12), CRHR2(4), CTSG(4), CYSLTR1(8), CYSLTR2(1), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), EDNRA(4), F2(11), F2R(6), F2RL1(1), F2RL2(4), F2RL3(4), FPR1(8), FSHB(1), GABBR1(18), GABBR2(15), GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), GABRB1(10), GABRB2(6), GABRB3(13), GABRD(8), GABRE(7), GABRG1(11), GABRG2(16), GABRG3(9), GABRP(6), GABRQ(12), GABRR1(7), GABRR2(7), GALR1(6), GALR2(11), GALR3(4), GH1(2), GH2(2), GHR(9), GHRHR(4), GHSR(8), GIPR(6), GLP1R(1), GLP2R(10), GLRA1(7), GLRA2(4), GLRA3(7), GLRB(10), GNRHR(5), GPR156(10), GPR35(5), GPR50(11), GPR63(3), GPR83(4), GRIA1(22), GRIA2(26), GRIA3(11), GRIA4(13), GRID1(23), GRID2(23), GRIK1(12), GRIK2(17), GRIK3(19), GRIK4(14), GRIK5(18), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), GRIN3A(21), GRIN3B(7), GRM1(43), GRM2(27), GRM3(22), GRM4(15), GRM6(18), GRM7(27), GRM8(27), GRPR(6), GZMA(4), HCRTR1(6), HCRTR2(8), HRH1(5), HRH2(6), HRH3(7), HRH4(8), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), LEP(3), LEPR(14), LHB(3), LTB4R(2), LTB4R2(6), MAS1(3), MC1R(6), MC2R(3), MC3R(11), MC4R(6), MC5R(6), MCHR1(8), MCHR2(6), MLNR(4), MTNR1A(4), MTNR1B(8), NMBR(3), NMUR1(6), NMUR2(6), NPBWR1(19), NPBWR2(9), NPFFR1(2), NPFFR2(12), NPY1R(5), NPY2R(7), NPY5R(4), NR3C1(9), NTSR1(10), NTSR2(5), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OXTR(8), P2RX2(7), P2RX3(7), P2RX4(7), P2RX5(7), P2RX7(2), P2RY1(3), P2RY10(11), P2RY11(3), P2RY13(4), P2RY14(5), P2RY2(5), P2RY6(10), P2RY8(8), PARD3(17), PRL(1), PRLHR(8), PRLR(5), PRSS1(3), PRSS3(3), PTAFR(4), PTGDR(8), PTGER2(7), PTGER3(8), PTGER4(12), PTGFR(5), PTH2R(11), RXFP1(9), RXFP2(12), SCTR(5), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), SSTR5(3), TAAR1(6), TAAR2(4), TAAR5(5), TAAR6(8), TACR1(4), TACR2(2), TACR3(15), TBXA2R(9), THRA(7), THRB(4), TRHR(7), TRPV1(8), TSHB(3), TSHR(12), TSPO(1), UTS2R(4), VIPR1(3), VIPR2(5)	125778413	1936	308	1867	662	710	225	266	463	268	4	0.000903	1.000	1.000
182	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(8), ACTG1(1), CHAD(7), COL11A1(47), COL11A2(18), COL17A1(13), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), COMP(6), DES(3), DSC1(2), DSC2(13), DSC3(7), DSG1(5), DSG2(6), DSG3(15), DSG4(7), FN1(33), GJA1(13), GJA10(5), GJA3(4), GJA4(8), GJA5(7), GJA8(8), GJA9(2), GJB1(2), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GJB7(3), GJC1(5), GJC2(4), GJD2(8), GJD4(3), IBSP(4), INA(7), ITGA6(10), ITGB4(24), KRT1(7), KRT10(5), KRT12(5), KRT13(10), KRT14(3), KRT15(3), KRT16(11), KRT17(7), KRT18(3), KRT19(5), KRT2(12), KRT20(4), KRT23(10), KRT24(6), KRT25(8), KRT27(11), KRT28(11), KRT3(10), KRT31(6), KRT32(6), KRT33A(10), KRT33B(8), KRT34(9), KRT35(7), KRT36(6), KRT37(2), KRT38(3), KRT39(8), KRT4(7), KRT40(3), KRT5(6), KRT6A(12), KRT6B(7), KRT6C(11), KRT7(5), KRT71(3), KRT72(14), KRT73(16), KRT74(7), KRT76(5), KRT77(2), KRT78(4), KRT79(8), KRT8(7), KRT81(5), KRT82(6), KRT83(4), KRT84(7), KRT85(5), KRT86(4), KRT9(2), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), LMNA(11), LMNB1(4), LMNB2(6), NES(17), PRPH(5), RELN(52), SPP1(4), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNC(27), TNN(31), TNR(26), TNXB(68), VIM(10), VTN(10), VWF(38)	145266499	1763	305	1718	672	570	251	186	400	339	17	0.830	1.000	1.000
183	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(6), ACTN1(7), ACTN2(26), ACTN4(16), APC(53), APC2(16), ARAF(13), ARHGEF1(12), ARHGEF12(14), ARHGEF4(14), ARHGEF6(11), ARHGEF7(10), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), BAIAP2(5), BCAR1(10), BDKRB1(4), BDKRB2(3), BRAF(18), CD14(1), CDC42(3), CFL1(1), CFL2(1), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CRK(1), CRKL(2), CSK(8), CYFIP1(14), CYFIP2(21), DIAPH1(14), DIAPH2(10), DIAPH3(18), DOCK1(20), EGF(11), EGFR(19), EZR(5), F2(11), F2R(6), FGD1(16), FGD3(17), FGF1(3), FGF10(5), FGF11(1), FGF12(9), FGF14(7), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(3), FGF3(1), FGF5(4), FGF6(7), FGF7(5), FGF8(1), FGF9(10), FGFR1(18), FGFR2(11), FGFR3(9), FGFR4(18), FN1(33), GIT1(4), GNA12(1), GNA13(7), GSN(12), HRAS(1), IQGAP1(15), IQGAP2(13), IQGAP3(19), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAD(17), ITGAE(16), ITGAL(22), ITGAM(10), ITGAV(18), ITGAX(13), ITGB1(11), ITGB2(12), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), LIMK1(6), LIMK2(3), MAP2K2(3), MAPK1(3), MAPK3(3), MOS(11), MRAS(4), MSN(11), MYH10(36), MYH14(24), MYH9(42), MYL2(9), MYL7(3), MYL9(2), MYLK(25), MYLK2(8), NCKAP1(13), NCKAP1L(14), NRAS(4), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDGFA(2), PDGFB(6), PDGFRA(13), PDGFRB(12), PFN1(1), PFN2(1), PFN3(3), PFN4(1), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PPP1R12B(16), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RDX(7), ROCK1(20), ROCK2(16), RRAS(1), RRAS2(3), SCIN(10), SLC9A1(12), SOS1(9), SOS2(18), SSH1(13), SSH2(22), SSH3(11), TIAM1(38), TIAM2(25), VAV1(13), VAV2(13), VAV3(14), VCL(11), WAS(4), WASF1(8), WASF2(7), WASL(5)	158864415	1850	297	1782	571	632	223	229	333	418	15	0.00343	1.000	1.000
184	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	237	ACVR1B(15), ACVR1C(5), AKT1(3), AKT2(10), AKT3(8), ARRB1(3), ARRB2(2), ATF2(4), ATF4(2), BDNF(9), BRAF(18), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1F(14), CACNA1G(27), CACNA1H(40), CACNA1I(26), CACNA1S(26), CACNA2D1(19), CACNA2D2(7), CACNA2D3(22), CACNA2D4(12), CACNB1(4), CACNB2(19), CACNB3(4), CACNB4(7), CACNG1(5), CACNG2(3), CACNG3(6), CACNG4(2), CACNG5(9), CACNG6(3), CACNG7(11), CACNG8(4), CASP3(2), CD14(1), CDC25B(6), CDC42(3), CHUK(5), CRK(1), CRKL(2), DAXX(11), DDIT3(5), DUSP1(3), DUSP10(8), DUSP14(3), DUSP16(12), DUSP2(1), DUSP3(1), DUSP4(2), DUSP5(9), DUSP6(4), DUSP7(1), DUSP8(2), DUSP9(8), ECSIT(6), EGF(11), EGFR(19), ELK1(4), ELK4(1), FAS(3), FASLG(5), FGF1(3), FGF10(5), FGF11(1), FGF12(9), FGF14(7), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(3), FGF3(1), FGF5(4), FGF6(7), FGF7(5), FGF8(1), FGF9(10), FGFR1(18), FGFR2(11), FGFR3(9), FGFR4(18), FLNA(28), FLNB(33), FLNC(38), FOS(1), GADD45B(1), GNA12(1), GRB2(4), HRAS(1), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), JUN(5), JUND(2), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP3K1(16), MAP3K10(13), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K6(10), MAP3K7(11), MAP3K8(2), MAP4K1(4), MAP4K2(10), MAP4K3(5), MAP4K4(13), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK7(8), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MAPKAPK2(3), MAPKAPK3(5), MAPKAPK5(4), MAPT(11), MAX(3), MEF2C(5), MKNK1(5), MKNK2(8), MOS(11), MRAS(4), MYC(6), NF1(32), NFATC2(26), NFATC4(16), NFKB1(8), NFKB2(9), NR4A1(5), NRAS(4), NTF3(5), NTRK1(9), NTRK2(16), PAK1(5), PAK2(12), PDGFA(2), PDGFB(6), PDGFRA(13), PDGFRB(12), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PPM1A(5), PPM1B(14), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PPP5C(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PTPN5(9), PTPN7(7), PTPRR(10), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF2(16), RASA1(19), RASA2(10), RASGRF1(15), RASGRF2(15), RASGRP1(7), RASGRP2(8), RASGRP3(6), RASGRP4(6), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KA5(5), RRAS(1), RRAS2(3), SOS1(9), SOS2(18), SRF(5), STK3(5), STK4(3), STMN1(2), TAOK1(11), TAOK2(20), TAOK3(12), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TNF(3), TNFRSF1A(6), TRAF2(4), TRAF6(6), ZAK(8)	162782560	1955	296	1874	580	671	238	246	336	449	15	1.02e-05	1.000	1.000
185	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(22), CD36(5), CD44(8), CD47(1), CHAD(7), COL11A1(47), COL11A2(18), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), DAG1(13), FN1(33), FNDC1(24), FNDC3A(10), FNDC4(6), FNDC5(3), GP5(14), GP6(4), GP9(3), HMMR(9), HSPG2(73), IBSP(4), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAV(18), ITGB1(11), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), RELN(52), SDC1(2), SDC2(2), SDC3(4), SDC4(5), SPP1(4), SV2A(18), SV2B(7), SV2C(12), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNC(27), TNN(31), TNR(26), TNXB(68), VTN(10), VWF(38)	131162178	1637	294	1555	540	508	216	163	388	346	16	0.0586	1.000	1.000
186	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRB1(9), ADRB2(8), ADRB3(6), ANXA6(3), ARRB1(3), ARRB2(2), ATP1A4(21), ATP1B1(7), ATP1B2(4), ATP1B3(4), ATP2A2(4), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(23), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1S(26), CACNB1(4), CACNB3(4), CALM1(2), CALM2(3), CALM3(1), CALR(2), CAMK1(3), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CASQ1(8), CASQ2(3), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), GJA1(13), GJA4(8), GJA5(7), GJB1(2), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GNA11(6), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAZ(17), GNB1(2), GNB2(4), GNB3(2), GNB4(4), GNB5(3), GNG13(3), GNG2(1), GNG7(4), GNGT1(3), GRK4(11), GRK5(1), GRK6(5), ITPR1(34), ITPR2(33), ITPR3(44), KCNB1(16), KCNJ3(18), KCNJ5(6), MIB1(4), NME7(1), PEA15(1), PKIA(2), PKIG(1), PLCB3(17), PRKACA(6), PRKACB(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RGS1(4), RGS10(5), RGS11(6), RGS14(4), RGS16(3), RGS17(4), RGS19(4), RGS2(5), RGS20(7), RGS3(16), RGS4(7), RGS5(2), RGS6(14), RGS7(4), RGS9(13), RYR1(68), RYR2(106), RYR3(81), SFN(1), SLC8A1(19), SLC8A3(12), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(4)	109336082	1526	276	1470	522	554	168	207	298	289	10	0.0319	1.000	1.000
187	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(10), ABLIM1(14), ABLIM2(14), ABLIM3(7), ARHGEF12(14), CDC42(3), CDK5(3), CFL1(1), CFL2(1), DCC(35), DPYSL2(4), DPYSL5(12), EFNA1(2), EFNA2(2), EFNA4(5), EFNA5(5), EFNB1(5), EFNB2(5), EFNB3(13), EPHA1(15), EPHA2(28), EPHA3(32), EPHA4(17), EPHA5(32), EPHA7(13), EPHA8(17), EPHB1(33), EPHB2(15), EPHB3(13), EPHB4(17), EPHB6(22), FES(13), FYN(9), GNAI1(3), GNAI2(4), GNAI3(8), GSK3B(6), HRAS(1), ITGB1(11), L1CAM(18), LIMK1(6), LIMK2(3), LRRC4C(4), MAPK1(3), MAPK3(3), MET(10), NCK1(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NGEF(7), NRAS(4), NRP1(13), NTN1(7), NTN4(4), NTNG1(24), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PLXNA1(39), PLXNA2(24), PLXNA3(24), PLXNB1(30), PLXNB2(22), PLXNB3(13), PLXNC1(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTK2(11), RAC1(1), RAC2(2), RAC3(4), RASA1(19), RGS3(16), RHOD(2), RND1(2), ROBO1(37), ROBO2(36), ROBO3(16), ROCK1(20), ROCK2(16), SEMA3A(16), SEMA3C(7), SEMA3D(17), SEMA3E(19), SEMA3F(11), SEMA3G(6), SEMA4A(11), SEMA4B(1), SEMA4C(13), SEMA4D(13), SEMA4F(9), SEMA4G(5), SEMA5A(28), SEMA5B(26), SEMA6A(17), SEMA6B(8), SEMA6C(11), SEMA6D(26), SEMA7A(9), SLIT1(9), SLIT2(38), SLIT3(21), SRGAP1(14), SRGAP3(12), UNC5A(14), UNC5B(11), UNC5C(19), UNC5D(24)	113499977	1508	276	1450	460	476	170	198	325	329	10	0.00386	1.000	1.000
188	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	125	ALCAM(12), CADM3(13), CD2(4), CD22(5), CD226(2), CD274(4), CD276(8), CD28(1), CD34(4), CD4(11), CD40(3), CD40LG(5), CD58(7), CD6(11), CD80(5), CD8A(4), CD8B(2), CD99(1), CDH15(10), CDH2(20), CDH3(12), CDH4(25), CDH5(12), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CNTN1(23), CNTN2(12), CNTNAP1(20), CNTNAP2(40), CTLA4(4), ESAM(6), F11R(2), GLG1(18), HLA-C(7), HLA-DMA(1), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(4), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), HLA-E(6), HLA-F(8), HLA-G(5), ICAM1(4), ICAM2(3), ICAM3(5), ICOS(4), ICOSLG(2), ITGA4(16), ITGA6(10), ITGA8(12), ITGA9(9), ITGAL(22), ITGAM(10), ITGAV(18), ITGB1(11), ITGB2(12), ITGB7(6), ITGB8(18), JAM2(2), JAM3(6), L1CAM(18), MADCAM1(2), MAG(21), MPZ(2), MPZL1(2), NCAM1(9), NCAM2(27), NEGR1(9), NEO1(16), NFASC(36), NLGN1(21), NLGN2(10), NLGN3(13), NRCAM(12), NRXN1(43), NRXN2(30), NRXN3(37), OCLN(8), PDCD1(5), PDCD1LG2(2), PTPRC(21), PTPRF(21), PTPRM(34), PVR(3), PVRL1(4), PVRL2(9), PVRL3(6), SDC1(2), SDC2(2), SDC3(4), SDC4(5), SELE(6), SELL(6), SELP(11), SELPLG(9), SIGLEC1(22), SPN(4), VCAM1(9), VCAN(45)	83722079	1146	264	1086	357	350	156	152	246	239	3	0.000759	1.000	1.000
189	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), AKT1(3), AKT2(10), AKT3(8), AMOTL1(11), ASH1L(40), CASK(7), CDC42(3), CDK4(2), CGN(16), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CRB3(2), CSNK2A1(5), CSNK2A2(8), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), CTTN(12), EPB41(15), EPB41L1(10), EPB41L2(12), EPB41L3(39), EXOC3(6), EXOC4(12), F11R(2), GNAI1(3), GNAI2(4), GNAI3(8), HCLS1(3), HRAS(1), IGSF5(5), INADL(18), JAM2(2), JAM3(6), LLGL1(10), LLGL2(9), MAGI1(26), MAGI2(28), MAGI3(11), MLLT4(29), MPDZ(30), MPP5(4), MRAS(4), MYH1(22), MYH10(36), MYH11(31), MYH13(28), MYH14(24), MYH15(14), MYH2(39), MYH3(32), MYH4(25), MYH6(24), MYH7(35), MYH7B(20), MYH8(20), MYH9(42), MYL2(9), MYL7(3), MYL9(2), NRAS(4), OCLN(8), PARD3(17), PARD6B(3), PARD6G(2), PPM1J(2), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PPP2R3A(11), PPP2R3B(15), PPP2R4(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), RAB13(3), RAB3B(4), RRAS(1), RRAS2(3), SPTAN1(22), SRC(5), SYMPK(10), TJAP1(4), TJP1(26), TJP2(17), TJP3(11), VAPA(3), YES1(4), ZAK(8)	112816093	1368	264	1320	423	458	162	176	301	266	5	0.0176	1.000	1.000
190	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	138	APC(53), APC2(16), AXIN1(15), AXIN2(20), BTRC(9), CACYBP(2), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CCND1(2), CCND2(2), CCND3(1), CER1(3), CHD8(27), CREBBP(46), CSNK1A1(5), CSNK1A1L(7), CSNK1E(9), CSNK2A1(5), CSNK2A2(8), CTBP1(5), CTBP2(8), CTNNB1(27), CTNNBIP1(2), CUL1(24), CXXC4(4), DAAM1(15), DAAM2(16), DKK1(12), DKK2(8), DKK4(5), DVL1(8), DVL2(10), DVL3(15), EP300(27), FBXW11(9), FOSL1(1), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD4(9), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GSK3B(6), JUN(5), LEF1(5), LRP5(31), LRP6(8), MAP3K7(11), MAPK10(4), MAPK8(6), MAPK9(5), MMP7(2), MYC(6), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NKD1(8), NKD2(2), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PORCN(5), PPARD(8), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRICKLE1(20), PRICKLE2(20), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PSEN1(5), RAC1(1), RAC2(2), RAC3(4), RBX1(1), ROCK1(20), ROCK2(16), RUVBL1(9), SENP2(7), SFRP1(7), SFRP2(6), SFRP4(5), SFRP5(1), SIAH1(3), SMAD2(9), SMAD3(6), SOX17(13), TBL1X(8), TBL1XR1(8), TBL1Y(2), TCF7(9), TCF7L1(8), TCF7L2(12), VANGL1(5), VANGL2(10), WIF1(3), WNT10A(6), WNT10B(2), WNT11(3), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4)	91988172	1248	257	1184	331	428	161	139	205	304	11	1.81e-07	1.000	1.000
191	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(4), ACTA2(7), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADM(1), ARRB1(3), ARRB2(2), ATF2(4), ATF3(2), ATF4(2), ATF5(5), ATP2A2(4), ATP2A3(11), CACNB3(4), CALCA(2), CALM1(2), CALM2(3), CALM3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CNN1(3), CNN2(1), CORIN(13), CRHR1(12), DGKZ(10), ETS2(4), FOS(1), GABPA(4), GABPB2(4), GBA2(6), GJA1(13), GNAQ(3), GNB1(2), GNB2(4), GNB3(2), GNB4(4), GNB5(3), GNG13(3), GNG2(1), GNG7(4), GNGT1(3), GRK4(11), GRK5(1), GRK6(5), GSTO1(1), GUCA2A(1), GUCA2B(4), GUCY1A3(17), IGFBP2(5), IGFBP3(5), IGFBP4(1), IGFBP6(1), IL1B(4), ITPR1(34), ITPR2(33), ITPR3(44), JUN(5), MAFF(1), MIB1(4), MYL2(9), MYL4(1), MYLK2(8), NFKB1(8), NOS1(39), NOS3(15), OXT(1), OXTR(8), PDE4B(6), PDE4D(5), PKIA(2), PKIG(1), PLCB3(17), PLCD1(7), PLCG1(22), PLCG2(19), PRKACA(6), PRKACB(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RAMP2(2), RAMP3(3), RGS1(4), RGS10(5), RGS11(6), RGS14(4), RGS16(3), RGS17(4), RGS19(4), RGS2(5), RGS20(7), RGS3(16), RGS4(7), RGS5(2), RGS6(14), RGS7(4), RGS9(13), RLN1(4), RYR1(68), RYR2(106), RYR3(81), SFN(1), SLC8A1(19), SP1(5), TNXB(68), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(4)	100699281	1286	257	1235	437	458	136	157	269	259	7	0.0949	1.000	1.000
192	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(7), ACTN2(26), ACTN4(16), DES(3), DMD(68), MYBPC1(9), MYBPC2(15), MYBPC3(12), MYH3(32), MYH6(24), MYH7(35), MYH8(20), MYL1(2), MYL2(9), MYL3(4), MYL4(1), MYL9(2), MYOM1(15), NEB(72), TCAP(4), TMOD1(3), TNNC2(1), TNNI1(1), TNNI2(6), TNNT1(6), TNNT2(3), TNNT3(7), TPM1(5), TPM2(2), TPM3(4), TPM4(4), TTN(569), VIM(10)	79893365	1001	255	966	305	269	120	174	322	99	17	0.0336	1.000	1.000
193	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(5), ACVR1B(15), ACVR2A(10), ACVR2B(5), AMHR2(9), BMP2(7), BMP7(7), BMPR1A(12), BMPR1B(9), BMPR2(21), CCL1(3), CCL11(1), CCL13(1), CCL15(2), CCL16(1), CCL18(3), CCL19(2), CCL2(1), CCL20(3), CCL22(2), CCL23(1), CCL24(2), CCL25(1), CCL27(2), CCL3(1), CCL5(3), CCL7(1), CCL8(2), CCR1(7), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CCR9(6), CD27(2), CD40(3), CD40LG(5), CD70(3), CLCF1(3), CNTF(3), CNTFR(6), CRLF2(2), CSF1(5), CSF1R(17), CSF2RA(10), CSF2RB(12), CSF3(1), CSF3R(13), CX3CL1(9), CX3CR1(4), CXCL10(1), CXCL2(2), CXCL5(1), CXCL9(2), CXCR3(2), CXCR6(2), EDA(5), EDA2R(3), EDAR(8), EGF(11), EGFR(19), EPO(3), EPOR(3), FAS(3), FASLG(5), FLT1(19), FLT3(12), FLT3LG(1), FLT4(31), GDF5(13), GH1(2), GH2(2), GHR(9), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL13(4), IL13RA1(5), IL15(1), IL15RA(5), IL17B(3), IL17RA(10), IL17RB(6), IL18(1), IL18R1(6), IL18RAP(3), IL19(1), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), IL1RAP(6), IL20(1), IL20RA(5), IL21(4), IL21R(10), IL22(2), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL25(4), IL26(4), IL2RA(2), IL2RB(3), IL2RG(9), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL6ST(6), IL7(2), IL7R(15), IL9R(2), INHBA(13), INHBB(12), INHBC(7), INHBE(2), KDR(17), KIT(13), KITLG(4), LEP(3), LEPR(14), LIF(4), LIFR(15), LTA(4), LTBR(2), MET(10), MPL(5), NGFR(7), OSM(4), OSMR(10), PDGFB(6), PDGFC(8), PDGFRA(13), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(2), PRL(1), PRLR(5), RELT(8), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFRSF11A(4), TNFRSF11B(5), TNFRSF12A(1), TNFRSF13B(7), TNFRSF13C(4), TNFRSF14(2), TNFRSF17(1), TNFRSF19(8), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(4), TNFRSF25(5), TNFRSF4(5), TNFRSF8(7), TNFRSF9(11), TNFSF10(9), TNFSF11(5), TNFSF13(6), TNFSF13B(4), TNFSF14(3), TNFSF15(5), TNFSF18(2), TNFSF4(1), TNFSF8(4), TPO(27), TSLP(1), VEGFB(2), VEGFC(12), XCL1(1), XCR1(5)	102024535	1120	246	1068	379	303	152	137	252	270	6	0.264	1.000	1.000
194	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRA2A(9), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), AGTR2(4), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), CCKAR(7), CCKBR(16), CCR1(7), CCR10(3), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CCR9(6), CCRL2(1), CHML(8), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CMKLR1(6), CNR1(13), CNR2(3), CX3CR1(4), CXCR3(2), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), EDNRA(4), F2R(6), F2RL1(1), F2RL2(4), F2RL3(4), FPR1(8), GALR1(6), GALR2(11), GALR3(4), GALT(3), GHSR(8), GNB2L1(3), GPR17(6), GPR173(7), GPR174(3), GPR27(8), GPR3(3), GPR35(5), GPR37(13), GPR37L1(8), GPR4(5), GPR50(11), GPR6(11), GPR63(3), GPR83(4), GPR85(4), GPR87(6), GRPR(6), HCRTR1(6), HCRTR2(8), HRH1(5), HRH2(6), HRH3(7), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), LTB4R(2), MAS1(3), MC1R(6), MC3R(11), MC4R(6), MC5R(6), MLNR(4), MTNR1A(4), MTNR1B(8), NMBR(3), NMUR1(6), NMUR2(6), NPY1R(5), NPY2R(7), NPY5R(4), NTSR1(10), NTSR2(5), OPN1SW(2), OPN3(4), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OR10A5(5), OR11A1(6), OR12D3(4), OR1C1(5), OR1F1(5), OR1Q1(7), OR2H1(2), OR5V1(7), OR7A5(3), OR7C1(7), OR8B8(7), OXTR(8), P2RY1(3), P2RY10(11), P2RY11(3), P2RY12(10), P2RY13(4), P2RY14(5), P2RY2(5), P2RY6(10), PTAFR(4), PTGDR(8), PTGER2(7), PTGER4(12), PTGFR(5), RGR(3), RHO(9), RRH(3), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), SUCNR1(4), TBXA2R(9), TRHR(7)	69212731	1007	241	965	394	394	110	149	207	147	0	0.214	1.000	1.000
195	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(6), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADK(4), ADSL(5), ADSS(6), ADSSL1(9), AK1(1), AK5(5), AK7(5), ALLC(6), AMPD1(12), AMPD2(17), AMPD3(19), APRT(3), ATIC(5), CANT1(5), DCK(4), DGUOK(4), ENPP1(7), ENPP3(12), ENTPD1(4), ENTPD2(6), ENTPD3(6), ENTPD4(13), ENTPD5(2), ENTPD6(6), ENTPD8(7), FHIT(1), GART(10), GDA(6), GMPR(3), GMPR2(1), GMPS(7), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), GUK1(4), IMPDH1(6), ITPA(1), NME2(3), NME4(2), NME6(3), NME7(1), NPR1(11), NPR2(10), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT2(5), NUDT5(1), NUDT9(2), PAPSS1(6), PAPSS2(6), PDE10A(18), PDE11A(11), PDE1A(7), PDE1C(14), PDE2A(16), PDE3B(23), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE5A(7), PDE6D(1), PDE6G(1), PDE6H(1), PDE7A(6), PDE7B(4), PDE8A(13), PDE8B(6), PDE9A(8), PFAS(12), PKLR(9), PNPT1(5), POLA1(8), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), PPAT(7), PRIM1(2), PRIM2(7), PRPS1(3), PRPS2(3), PRUNE(5), RFC5(2), RRM1(5), RRM2(3), RRM2B(4), XDH(23), ZNRD1(2)	95626467	1029	235	997	337	315	134	156	218	203	3	0.144	1.000	1.000
196	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADRB1(9), CSNK1D(4), DRD1(4), DRD2(10), EGF(11), EGFR(19), GJA1(13), GJD2(8), GNA11(6), GNAI1(3), GNAI2(4), GNAI3(8), GNAQ(3), GNAS(38), GRB2(4), GRM1(43), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), HRAS(1), HTR2A(8), HTR2B(5), HTR2C(10), ITPR1(34), ITPR2(33), ITPR3(44), MAP2K2(3), MAP2K5(1), MAP3K2(6), MAPK1(3), MAPK3(3), MAPK7(8), NPR1(11), NPR2(10), NRAS(4), PDGFA(2), PDGFB(6), PDGFC(8), PDGFD(10), PDGFRA(13), PDGFRB(12), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKG1(12), PRKG2(15), PRKX(6), RAF1(9), SOS1(9), SOS2(18), SRC(5), TJP1(26), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9)	75545389	987	232	952	343	326	130	125	222	178	6	0.280	1.000	1.000
197	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	126	ACACA(28), ACACB(40), AKT1(3), AKT2(10), AKT3(8), ARAF(13), BAD(4), BRAF(18), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CBL(5), CBLB(2), CBLC(7), CRK(1), CRKL(2), EIF4EBP1(4), ELK1(4), EXOC7(14), FASN(27), FBP1(4), FBP2(6), FLOT2(9), FOXO1(5), G6PC2(1), GCK(9), GRB2(4), GSK3B(6), GYS1(8), GYS2(9), HRAS(1), IKBKB(10), INPP5D(8), INSR(17), IRS1(27), IRS2(10), IRS4(25), LIPE(7), MAP2K2(3), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MKNK1(5), MKNK2(8), NRAS(4), PCK1(12), PCK2(10), PDE3A(19), PDE3B(23), PDPK1(1), PFKL(8), PFKM(2), PFKP(21), PHKA1(10), PHKA2(15), PHKB(7), PHKG1(2), PHKG2(11), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PKLR(9), PPARGC1A(11), PPP1CA(2), PPP1CC(4), PPP1R3A(31), PPP1R3B(7), PPP1R3C(4), PPP1R3D(4), PRKAA1(7), PRKAA2(10), PRKAB2(4), PRKACA(6), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCI(7), PRKCZ(2), PRKX(6), PTPN1(3), PTPRF(21), PYGB(14), PYGL(11), PYGM(14), RAF1(9), RAPGEF1(11), RHEB(2), RPS6(1), RPS6KB1(6), RPS6KB2(9), SH2B2(5), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SLC2A4(5), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SORBS1(12), SOS1(9), SOS2(18), SREBF1(15), TRIP10(11), TSC1(10), TSC2(14)	91144123	1055	232	1011	322	354	136	115	182	260	8	0.0139	1.000	1.000
198	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(3), AKT2(10), AKT3(8), BCL2L1(1), CBL(5), CBLB(2), CBLC(7), CCND1(2), CCND2(2), CCND3(1), CISH(4), CLCF1(3), CNTF(3), CNTFR(6), CREBBP(46), CRLF2(2), CSF2RA(10), CSF2RB(12), CSF3(1), CSF3R(13), EP300(27), EPO(3), EPOR(3), GH1(2), GH2(2), GHR(9), GRB2(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL13(4), IL13RA1(5), IL13RA2(7), IL15(1), IL15RA(5), IL19(1), IL20(1), IL20RA(5), IL21(4), IL21R(10), IL22(2), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL26(4), IL2RA(2), IL2RB(3), IL2RG(9), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL6ST(6), IL7(2), IL7R(15), IL9R(2), IRF9(7), JAK1(19), JAK2(12), JAK3(12), LEP(3), LEPR(14), LIF(4), LIFR(15), MPL(5), MYC(6), OSM(4), OSMR(10), PIAS1(10), PIAS2(14), PIAS3(10), PIAS4(8), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIM1(2), PRL(1), PRLR(5), PTPN11(8), PTPN6(6), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SOCS5(5), SOCS7(5), SOS1(9), SOS2(18), SPRED1(13), SPRED2(9), SPRY1(2), SPRY3(8), SPRY4(6), STAM(9), STAM2(6), STAT1(11), STAT2(6), STAT3(7), STAT4(9), STAT5A(10), STAT5B(13), STAT6(7), TPO(27), TSLP(1), TYK2(12)	83615051	896	226	845	277	234	119	124	190	224	5	0.161	1.000	1.000
199	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	70	ARAF(13), BRAF(18), CACNA1A(34), CRHR1(12), GNA11(6), GNA12(1), GNA13(7), GNAI1(3), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAS(38), GNAZ(17), GRIA1(22), GRIA2(26), GRIA3(11), GRID2(23), GRM1(43), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), HRAS(1), IGF1(2), IGF1R(20), ITPR1(34), ITPR2(33), ITPR3(44), LYN(7), MAP2K2(3), MAPK1(3), MAPK3(3), NOS1(39), NOS3(15), NPR1(11), NPR2(10), NRAS(4), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PRKCA(8), PRKCG(17), PRKG1(12), PRKG2(15), RAF1(9), RYR1(68)	62376136	886	218	842	259	310	104	115	199	151	7	0.00469	1.000	1.000
200	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	68	ACP1(9), ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), ACVR1B(15), ACVR1C(5), BAIAP2(5), CDC42(3), CREBBP(46), CSNK2A1(5), CSNK2A2(8), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), EGFR(19), EP300(27), ERBB2(23), FARP2(6), FER(14), FGFR1(18), FYN(9), IGF1R(20), INSR(17), IQGAP1(15), LEF1(5), LMO7(22), MAP3K7(11), MAPK1(3), MAPK3(3), MET(10), MLLT4(29), PARD3(17), PTPN1(3), PTPN6(6), PTPRB(26), PTPRF(21), PTPRJ(30), PTPRM(34), PVRL1(4), PVRL2(9), PVRL3(6), PVRL4(10), RAC1(1), RAC2(2), RAC3(4), SMAD2(9), SMAD3(6), SNAI1(2), SNAI2(13), SORBS1(12), SRC(5), SSX2IP(10), TCF7(9), TCF7L1(8), TCF7L2(12), TGFBR1(8), TJP1(26), VCL(11), WAS(4), WASF1(8), WASF2(7), WASL(5), YES1(4)	65466693	827	215	787	239	253	118	104	159	186	7	0.00218	1.000	1.000
201	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(7), ACTN2(26), ACTN4(16), ARHGAP5(26), BCAR1(10), CD99(1), CDC42(3), CDH5(12), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), CYBA(1), CYBB(8), ESAM(6), EZR(5), F11R(2), GNAI1(3), GNAI2(4), GNAI3(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGAM(10), ITGB1(11), ITGB2(12), ITK(5), JAM2(2), JAM3(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MLLT4(29), MMP2(10), MMP9(20), MSN(11), MYL2(9), MYL7(3), MYL9(2), NCF1(3), NCF2(3), NCF4(3), NOX1(7), NOX3(7), OCLN(8), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PRKCA(8), PRKCG(17), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAC1(1), RAC2(2), RAP1A(3), RAP1B(6), RAPGEF3(4), RAPGEF4(15), RASSF5(4), RHOH(1), ROCK1(20), ROCK2(16), SIPA1(9), THY1(1), TXK(2), VASP(2), VAV1(13), VAV2(13), VAV3(14), VCAM1(9), VCL(11)	70150734	860	215	813	267	287	108	96	161	197	11	0.0169	1.000	1.000
202	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), AKAP1(3), AKAP10(3), AKAP11(17), AKAP12(20), AKAP2(16), AKAP3(11), AKAP4(11), AKAP5(1), AKAP6(32), AKAP7(2), AKAP8(11), AKAP9(41), ARHGEF1(12), CALM1(2), CALM2(3), CALM3(1), CHMP1B(1), GNA11(6), GNA12(1), GNA13(7), GNA14(5), GNA15(4), GNAI2(4), GNAI3(8), GNAL(3), GNAO1(1), GNAQ(3), GNAZ(17), GNB1(2), GNB2(4), GNB3(2), GNB5(3), GNG10(1), GNG13(3), GNG7(4), GNGT1(3), GNGT2(3), HRAS(1), IL18BP(2), ITPR1(34), KCNJ3(18), NRAS(4), PALM2(8), PDE1A(7), PDE1B(5), PDE1C(14), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE7A(6), PDE7B(4), PDE8A(13), PDE8B(6), PLCB3(17), PPP3CA(13), PPP3CC(6), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), PRKD1(23), PRKD3(6), RRAS(1), SLC9A1(12), USP5(6)	67919725	808	214	772	268	241	98	123	174	169	3	0.138	1.000	1.000
203	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(10), ANAPC1(17), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC4(2), ANAPC5(5), ANAPC7(6), ATM(49), ATR(28), BUB1(13), BUB1B(13), BUB3(4), CCNA1(10), CCNA2(1), CCNB1(3), CCNB3(21), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNH(3), CDC14A(19), CDC14B(7), CDC16(7), CDC20(7), CDC23(6), CDC25A(5), CDC25B(6), CDC25C(11), CDC26(2), CDC27(5), CDC6(8), CDC7(7), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2B(1), CDKN2C(1), CDKN2D(4), CHEK1(6), CHEK2(10), CREBBP(46), CUL1(24), DBF4(7), E2F1(4), E2F2(5), E2F3(3), EP300(27), ESPL1(21), FZR1(8), GADD45B(1), GSK3B(6), HDAC1(9), HDAC2(6), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), PCNA(2), PKMYT1(6), PLK1(16), PRKDC(56), PTTG1(2), RB1(14), RBL1(12), RBL2(7), RBX1(1), SFN(1), SKP2(6), SMAD2(9), SMAD3(6), SMC1A(7), SMC1B(9), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9), WEE1(6), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3)	78154219	791	213	744	210	209	90	113	154	220	5	0.0154	1.000	1.000
204	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	91	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ATF4(2), CACNA1C(44), CACNA1D(43), CACNA1F(14), CACNA1S(26), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CDC42(3), CGA(1), EGFR(19), ELK1(4), FSHB(1), GNA11(6), GNAQ(3), GNAS(38), GNRH1(2), GNRH2(2), GNRHR(5), GRB2(4), HBEGF(2), HRAS(1), ITPR1(34), ITPR2(33), ITPR3(44), JUN(5), LHB(3), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK7(8), MAPK8(6), MAPK9(5), MMP14(7), MMP2(10), NRAS(4), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLD1(22), PLD2(19), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCD(10), PRKX(6), PTK2B(16), RAF1(9), SOS1(9), SOS2(18), SRC(5)	73138190	930	210	901	308	317	117	118	179	190	9	0.0947	1.000	1.000
205	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(5), ACVR1B(15), ACVRL1(7), AKT1(3), AURKB(5), BMPR1A(12), BMPR2(21), BUB1(13), CDIPT(1), CDKL2(4), CDS1(5), CDS2(3), CLK1(4), CLK2(15), CLK4(5), COL4A3BP(5), CSNK2A1(5), CSNK2A2(8), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), IMPA1(7), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPPL1(27), ITPKA(2), ITPKB(14), MAP3K10(13), MOS(11), NEK1(6), NEK3(2), OCRL(10), PAK4(9), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3CB(13), PIK3CG(24), PIM2(2), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCG1(22), PLCG2(19), PLK3(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), PRKG1(12), RAF1(9), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KB1(6), STK11(6), TGFBR1(8), VRK1(2)	64722017	765	210	722	180	220	88	100	143	207	7	8.97e-05	1.000	1.000
206	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(6), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADK(4), ADSL(5), ADSS(6), AK1(1), AK5(5), ALLC(6), AMPD1(12), AMPD2(17), AMPD3(19), APRT(3), ATIC(5), ATP1B1(7), ATP5A1(3), ATP5B(9), ATP5C1(5), ATP5F1(3), ATP5G2(2), ATP5G3(2), ATP5J(3), ATP5J2(1), CANT1(5), DCK(4), DGUOK(4), ENPP1(7), ENPP3(12), ENTPD1(4), ENTPD2(6), FHIT(1), GART(10), GDA(6), GMPS(7), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), GUK1(4), IMPDH1(6), ITPA(1), NME2(3), NPR1(11), NPR2(10), NT5E(5), NT5M(6), NUDT2(5), PAPSS1(6), PAPSS2(6), PDE1A(7), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE5A(7), PDE6B(14), PDE6C(5), PDE6G(1), PDE7B(4), PDE8A(13), PDE9A(8), PFAS(12), PKLR(9), POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14), PPAT(7), PRPS1(3), PRPS2(3), PRUNE(5), RRM1(5), RRM2(3)	75053874	817	209	792	274	236	118	127	172	161	3	0.293	1.000	1.000
207	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	94	ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ASIP(2), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CREB1(4), CREB3L1(5), CREB3L2(4), CREB3L3(6), CREB3L4(3), CREBBP(46), CTNNB1(27), DCT(16), DVL1(8), DVL2(10), DVL3(15), EDN1(4), EP300(27), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD4(9), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GNAI1(3), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAS(38), GSK3B(6), HRAS(1), KIT(13), KITLG(4), LEF1(5), MAP2K2(3), MAPK1(3), MAPK3(3), MC1R(6), MITF(11), NRAS(4), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), POMC(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), RAF1(9), TCF7(9), TCF7L1(8), TCF7L2(12), TYR(15), TYRP1(9), WNT10A(6), WNT10B(2), WNT11(3), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4)	61882106	882	208	838	291	330	104	116	158	170	4	0.0233	1.000	1.000
208	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(2), CALM2(3), CALM3(1), CALML3(1), CDIPT(1), CDS1(5), CDS2(3), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), FN3K(4), IMPA1(7), IMPA2(2), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPP5B(10), INPP5D(8), INPP5E(8), INPPL1(27), ITPK1(6), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), OCRL(10), PI4KA(22), PI4KB(10), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3C3(16), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PRKCA(8), PRKCG(17), PTPMT1(1), SYNJ1(11), SYNJ2(20)	71117985	777	204	730	203	255	92	96	145	180	9	0.000299	1.000	1.000
209	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT1(3), AKT3(8), BCAR1(10), CAPN1(7), CAPN10(10), CAPN11(6), CAPN2(10), CAPN3(8), CAPN5(12), CAPN6(7), CAPN7(6), CAPN9(5), CAPNS1(3), CAV1(5), CAV2(1), CAV3(2), CDC42(3), CRK(1), CSK(8), DOCK1(20), FYN(9), GIT2(5), GRB2(4), ILK(9), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAD(17), ITGAE(16), ITGAL(22), ITGAM(10), ITGAV(18), ITGAX(13), ITGB1(11), ITGB2(12), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAPK10(4), MAPK12(1), MAPK4(8), MAPK6(3), MAPK7(8), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PDPK1(1), PIK3R2(13), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(11), RHO(9), ROCK1(20), ROCK2(16), SDCCAG8(7), SHC1(7), SHC3(12), SORBS1(12), SOS1(9), SRC(5), TLN1(28), TNS1(39), VASP(2), VAV2(13), VAV3(14), VCL(11), ZYX(7)	77891649	842	203	818	248	272	110	107	147	200	6	0.00436	1.000	1.000
210	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(25), ABCA10(21), ABCA12(44), ABCA13(63), ABCA2(27), ABCA3(21), ABCA4(22), ABCA5(24), ABCA6(18), ABCA7(22), ABCA8(14), ABCA9(19), ABCB1(33), ABCB10(14), ABCB11(11), ABCB4(29), ABCB5(21), ABCB6(12), ABCB7(5), ABCB8(13), ABCB9(5), ABCC1(14), ABCC10(14), ABCC11(20), ABCC12(18), ABCC2(17), ABCC3(14), ABCC4(20), ABCC5(11), ABCC6(17), ABCC8(23), ABCC9(45), ABCD1(10), ABCD2(5), ABCD3(4), ABCD4(8), ABCG1(13), ABCG2(5), ABCG4(4), ABCG5(3), ABCG8(6), CFTR(15), TAP1(5), TAP2(10)	69095352	764	199	726	196	219	109	101	153	175	7	9.26e-06	1.000	1.000
211	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	119	ARAF(13), BID(2), BRAF(18), CASP3(2), CD244(2), CD247(4), FAS(3), FASLG(5), FCGR3A(5), FYN(9), GRB2(4), GZMB(2), HCST(1), HLA-C(7), HLA-E(6), HLA-G(5), HRAS(1), ICAM1(4), ICAM2(3), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), ITGAL(22), ITGB2(12), KIR2DL3(4), KIR3DL1(10), KIR3DL2(3), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), LAT(3), LCK(4), LCP2(10), MAP2K2(3), MAPK1(3), MAPK3(3), MICA(2), MICB(5), NCR1(3), NCR2(4), NCR3(1), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NRAS(4), PAK1(5), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRF1(13), PRKCA(8), PRKCG(17), PTK2B(16), PTPN11(8), PTPN6(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SH2D1A(1), SH2D1B(1), SH3BP2(7), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SYK(9), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFSF10(9), TYROBP(4), ULBP1(5), ULBP2(1), ULBP3(1), VAV1(13), VAV2(13), VAV3(14), ZAP70(13)	63165876	759	199	720	209	223	96	90	155	192	3	0.000536	1.000	1.000
212	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	63	ADCY1(21), ADCY8(37), ARAF(13), ATF4(2), BRAF(18), CACNA1C(44), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CREBBP(46), EP300(27), GNAQ(3), GRIA1(22), GRIA2(26), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), GRM1(43), HRAS(1), ITPR1(34), ITPR2(33), ITPR3(44), MAP2K2(3), MAPK1(3), MAPK3(3), NRAS(4), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PPP1R1A(1), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF3(4), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6)	55488400	746	199	717	231	236	96	104	147	157	6	0.0131	1.000	1.000
213	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(14), AMY2A(7), ASCC3(37), ATP13A2(16), DDX18(14), DDX19A(5), DDX23(12), DDX4(9), DDX41(9), DDX47(1), DDX50(12), DDX51(7), DDX52(7), DDX54(17), DDX55(5), DDX56(8), DHX58(11), ENPP1(7), ENPP3(12), ENTPD7(10), EP400(47), ERCC2(9), ERCC3(8), G6PC2(1), GAA(8), GANC(9), GBA(12), GBE1(7), GCK(9), GPI(6), GUSB(10), GYS1(8), GYS2(9), HK1(17), HK2(12), HK3(11), IFIH1(10), LYZL1(4), MGAM(19), MOV10L1(9), NUDT5(1), NUDT8(1), PGM1(3), PGM3(13), PYGB(14), PYGL(11), PYGM(14), RAD54B(3), RAD54L(4), RUVBL2(9), SETX(24), SI(35), SKIV2L2(13), SMARCA2(31), SMARCA5(10), TREH(3), UGDH(8), UGP2(9), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), UXS1(8)	71772971	754	196	723	218	200	85	110	169	187	3	0.0808	1.000	1.000
214	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(10), ACTN1(7), ACTR2(2), ACTR3(2), AKT1(3), AKT2(10), AKT3(8), ANGPTL2(6), ARHGEF6(11), ARHGEF7(10), BCAR1(10), BRAF(18), CAV1(5), CDC42(3), CRK(1), CSE1L(7), DOCK1(20), EPHB2(15), FYN(9), GRB2(4), GRB7(6), ILK(9), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGB3BP(1), MAP2K4(9), MAP3K11(9), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MRAS(4), MYLK(25), MYLK2(8), P4HB(3), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PIK3CB(13), PKLR(9), PLCG1(22), PLCG2(19), PTK2(11), RAF1(9), RHO(9), ROCK1(20), ROCK2(16), SHC1(7), SOS1(9), SOS2(18), SRC(5), TERF2IP(5), TLN1(28), TLN2(32), VASP(2), WAS(4), ZYX(7)	69129564	708	194	690	216	240	101	74	118	169	6	0.0466	1.000	1.000
215	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	79	ABL1(10), ABL2(16), AKT1(3), AKT2(10), AKT3(8), ARAF(13), AREG(2), BAD(4), BRAF(18), BTC(2), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CBL(5), CBLB(2), CBLC(7), CDKN1A(5), CDKN1B(1), CRK(1), CRKL(2), EGF(11), EGFR(19), EIF4EBP1(4), ELK1(4), ERBB2(23), EREG(3), GAB1(4), GRB2(4), GSK3B(6), HBEGF(2), HRAS(1), JUN(5), MAP2K2(3), MAP2K4(9), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MYC(6), NCK1(6), NCK2(8), NRAS(4), NRG1(16), NRG2(9), NRG3(24), NRG4(2), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PRKCA(8), PRKCG(17), PTK2(11), RAF1(9), RPS6KB1(6), RPS6KB2(9), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SRC(5), STAT5A(10), STAT5B(13), TGFA(3)	54646056	663	189	627	193	206	92	77	118	166	4	0.0209	1.000	1.000
216	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(3), AKT2(10), AKT3(8), BCL10(2), CARD11(27), CBL(5), CBLB(2), CBLC(7), CD247(4), CD28(1), CD3E(2), CD4(11), CD40LG(5), CD8A(4), CD8B(2), CDC42(3), CDK4(2), CHUK(5), CTLA4(4), FOS(1), FYN(9), GRAP2(5), GRB2(4), HRAS(1), ICOS(4), IFNG(2), IKBKB(10), IL10(2), IL4(4), ITK(5), JUN(5), LAT(3), LCK(4), LCP2(10), MALT1(3), MAP3K8(2), NCK1(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(4), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDCD1(5), PDK1(3), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKCQ(14), PTPN6(6), PTPRC(21), RASGRP1(7), SOS1(9), SOS2(18), TEC(4), TNF(3), VAV1(13), VAV2(13), VAV3(14), ZAP70(13)	57699029	644	189	610	191	204	78	81	127	151	3	0.0415	1.000	1.000
217	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(25), BDKRB1(4), BDKRB2(3), C1QA(5), C1QB(1), C1QC(2), C1S(10), C2(2), C3(34), C3AR1(10), C4BPA(5), C4BPB(3), C5(13), C5AR1(6), C6(13), C7(7), C8A(8), C8B(11), C9(8), CD46(3), CD55(3), CFB(8), CFH(27), CFI(14), CPB2(10), CR2(25), F10(8), F11(5), F12(3), F13A1(19), F13B(17), F2(11), F2R(6), F3(2), F5(22), F7(11), F8(29), F9(9), FGA(12), FGB(6), FGG(5), KLKB1(6), KNG1(11), MASP1(3), MASP2(6), MBL2(4), PLAT(7), PLAUR(6), PLG(18), PROC(4), PROS1(11), SERPINA1(7), SERPINA5(8), SERPINC1(5), SERPIND1(5), SERPINE1(3), SERPINF2(8), SERPING1(8), TFPI(5), THBD(2), VWF(38)	51188791	590	188	564	162	153	75	87	134	140	1	0.0131	1.000	1.000
218	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(8), ALG6(4), CCKBR(16), CCR2(5), CCR3(12), CCR5(4), CELSR1(43), CELSR2(41), CELSR3(58), CHRM2(19), CHRM3(12), CIDEB(2), CXCR3(2), DRD4(5), EDNRA(4), EMR2(10), EMR3(4), F2R(6), GHRHR(4), GNRHR(5), GPR116(14), GPR132(5), GPR133(16), GPR135(11), GPR143(4), GPR17(6), GPR18(3), GPR55(9), GPR56(10), GPR61(9), GPR84(3), GRM1(43), GRPR(6), HRH4(8), LGR6(15), LPHN2(23), LPHN3(23), LTB4R2(6), NTSR1(10), OR2M4(6), P2RY11(3), P2RY13(4), PTGFR(5), SMO(15), SSTR2(4), TAAR5(5), TSHR(12), VN1R1(4)	38156342	546	187	529	149	183	73	69	131	88	2	9.75e-05	1.000	1.000
219	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(5), ACVR1B(15), ACVR1C(5), ACVR2A(10), ACVR2B(5), ACVRL1(7), AMHR2(9), BMP2(7), BMP4(6), BMP5(11), BMP6(12), BMP7(7), BMP8A(1), BMP8B(3), BMPR1A(12), BMPR1B(9), BMPR2(21), CDKN2B(1), CHRD(10), COMP(6), CREBBP(46), CUL1(24), DCN(10), E2F4(2), E2F5(4), EP300(27), FST(5), GDF5(13), GDF6(19), GDF7(4), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(13), INHBB(12), INHBC(7), INHBE(2), LEFTY1(3), LEFTY2(3), LTBP1(22), MAPK1(3), MAPK3(3), MYC(6), NODAL(1), NOG(2), PITX2(5), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), RBL1(12), RBL2(7), RBX1(1), ROCK1(20), ROCK2(16), RPS6KB1(6), RPS6KB2(9), SMAD1(4), SMAD2(9), SMAD3(6), SMAD5(2), SMAD6(7), SMAD7(7), SMAD9(13), SMURF1(7), SMURF2(5), SP1(5), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNF(3), ZFYVE16(14), ZFYVE9(10)	56389166	715	186	680	216	220	79	97	116	198	5	0.0530	1.000	1.000
220	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	78	ABL1(10), ATM(49), BUB1(13), BUB1B(13), BUB3(4), CCNA1(10), CCNA2(1), CCNB1(3), CCNB3(21), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNH(3), CDAN1(13), CDC14A(19), CDC14B(7), CDC20(7), CDC25A(5), CDC25B(6), CDC25C(11), CDC6(8), CDC7(7), CDK2(4), CDK4(2), CDKN1A(5), CHEK1(6), CHEK2(10), DTX4(12), E2F1(4), E2F2(5), E2F3(3), E2F4(2), E2F5(4), EP300(27), ESPL1(21), GSK3B(6), HDAC1(9), HDAC2(6), HDAC3(7), HDAC4(29), HDAC5(13), HDAC6(9), HDAC8(3), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), MPEG1(10), MPL(5), PCNA(2), PLK1(16), PRKDC(56), PTPRA(15), PTTG1(2), RB1(14), RBL1(12), SKP2(6), TBC1D8(13), TFDP1(5), TGFB1(3), WEE1(6)	61907395	657	185	618	174	179	81	96	123	172	6	0.0128	1.000	1.000
221	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(8), BAD(4), BCL2(4), CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAMK2B(7), CAMK4(10), CD3E(2), CD69(4), CDKN1A(5), CNR1(13), CREBBP(46), CSNK2A1(5), CTLA4(4), EGR2(9), EGR3(9), EP300(27), FCER1A(5), FCGR3A(5), FOS(1), FOSL1(1), GATA3(19), GATA4(4), GSK3A(4), GSK3B(6), HRAS(1), ICOS(4), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL13(4), IL1B(4), IL2RA(2), IL3(1), IL4(4), ITK(5), JUNB(5), KPNA5(8), MAPK14(2), MAPK8(6), MAPK9(5), MEF2A(2), MEF2B(6), MEF2D(8), MYF5(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB2(9), NFKBIB(8), NFKBIE(1), NPPB(3), NUP214(29), OPRD1(4), P2RX7(2), PAK1(5), PIN1(2), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTPRC(21), RELA(7), RPL13A(4), SFN(1), SLA(6), SP1(5), SP3(5), TGFB1(3), TNF(3), TRAF2(4), TRPV6(9), VAV1(13), VAV2(13), VAV3(14), XPO5(4)	53008757	583	182	556	184	171	86	78	118	128	2	0.0641	1.000	1.000
222	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(10), CD14(1), CD19(5), CD1A(13), CD1B(7), CD1C(10), CD1D(13), CD2(4), CD22(5), CD33(9), CD34(4), CD36(5), CD37(2), CD38(5), CD3E(2), CD4(11), CD44(8), CD5(4), CD55(3), CD7(5), CD8A(4), CD8B(2), CD9(1), CR2(25), CSF1(5), CSF1R(17), CSF2RA(10), CSF3(1), CSF3R(13), DNTT(5), EPO(3), EPOR(3), FCER2(4), FCGR1A(4), FLT3(12), FLT3LG(1), GP5(14), GP9(3), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), IL11(3), IL11RA(2), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), IL2RA(2), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL7(2), IL7R(15), IL9R(2), ITGA1(7), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGAM(10), ITGB3(6), KIT(13), KITLG(4), MME(10), MS4A1(2), TFRC(2), THPO(6), TNF(3), TPO(27)	45432421	499	179	469	136	130	60	69	110	128	2	0.00945	1.000	1.000
223	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	54	APC(53), AXIN1(15), CCND1(2), CCND2(2), CCND3(1), CSNK1E(9), CTNNB1(27), DVL1(8), DVL2(10), DVL3(15), FBXW2(2), FOSL1(1), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GSK3B(6), JUN(5), LDLR(12), MAPK10(4), MAPK9(5), MYC(6), PPP2R5C(6), PPP2R5E(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RAC1(1), SFRP4(5), TCF7(9), WNT10A(6), WNT10B(2), WNT11(3), WNT2(6), WNT2B(13), WNT3(5), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7)	33767790	474	178	448	155	162	48	46	93	118	7	0.113	1.000	1.000
224	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(1), ALG1(8), ALG10B(10), ALG11(8), ALG12(10), ALG13(8), ALG14(2), ALG2(3), ALG3(4), ALG6(4), ALG8(3), ALG9(2), B3GNT1(4), B3GNT2(5), B3GNT6(5), B3GNT7(6), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), B4GALT5(4), B4GALT7(6), C1GALT1(3), C1GALT1C1(6), CHPF(4), CHST1(20), CHST11(4), CHST12(6), CHST13(5), CHST14(2), CHST2(15), CHST3(8), CHST4(7), CHST6(11), CHST7(7), CHSY1(9), DPAGT1(6), EXT1(22), EXT2(7), EXTL1(8), EXTL2(2), EXTL3(12), FUT11(3), FUT8(9), GALNT1(4), GALNT10(8), GALNT11(6), GALNT12(3), GALNT13(9), GALNT14(12), GALNT2(7), GALNT3(4), GALNT4(6), GALNT5(12), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GALNTL5(3), GANAB(19), GCNT1(1), GCNT3(4), GCNT4(4), HS2ST1(3), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), HS3ST5(8), HS6ST1(7), HS6ST2(9), HS6ST3(9), MAN1A1(4), MAN1A2(5), MAN1B1(6), MAN1C1(10), MAN2A1(10), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), MGAT5B(7), NDST1(13), NDST2(13), NDST3(18), NDST4(17), OGT(7), RPN1(4), RPN2(6), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7), ST6GAL1(1), ST6GALNAC1(5), STT3B(5), UST(10), WBSCR17(27), XYLT1(11)	63093228	710	177	671	260	242	88	80	144	153	3	0.874	1.000	1.000
225	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(7), BMP4(6), BMP5(11), BMP6(12), BMP7(7), BMP8A(1), BMP8B(3), BTRC(9), CSNK1A1(5), CSNK1A1L(7), CSNK1D(4), CSNK1E(9), CSNK1G1(7), CSNK1G2(7), CSNK1G3(10), DHH(2), FBXW11(9), GAS1(4), GLI1(23), GLI2(18), GLI3(60), GSK3B(6), HHIP(20), IHH(7), LRP2(61), PRKACA(6), PRKACB(6), PRKACG(9), PRKX(6), PTCH1(29), PTCH2(13), RAB23(2), SHH(6), SMO(15), STK36(9), SUFU(6), WNT10A(6), WNT10B(2), WNT11(3), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4), ZIC2(7)	34921886	517	171	486	158	186	69	55	92	109	6	0.0323	1.000	1.000
226	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(40), ASH2L(4), CARM1(8), CTCFL(14), DOT1L(18), EED(7), EHMT1(18), EHMT2(19), EZH1(8), EZH2(5), FBXO11(13), HCFC1(19), HSF4(8), JMJD4(4), JMJD6(3), KDM6A(14), MEN1(11), NSD1(27), OGT(7), PAXIP1(7), PPP1CA(2), PPP1CC(4), PRDM2(38), PRDM7(2), PRDM9(23), PRMT1(3), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), RBBP5(5), SATB1(19), SETD1A(24), SETD2(20), SETD7(3), SETD8(1), SETDB1(17), SETDB2(12), SETMAR(3), SMYD3(3), STK38(6), SUV39H1(6), SUV39H2(2), SUV420H1(18), SUV420H2(6), SUZ12(3), WHSC1(25), WHSC1L1(18)	69604920	539	168	517	139	154	66	73	103	135	8	0.0193	1.000	1.000
227	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	91	AKT1(3), AKT2(10), AKT3(8), CCL3(1), CCL5(3), CD14(1), CD40(3), CD80(5), CHUK(5), CXCL10(1), CXCL9(2), FADD(3), FOS(1), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IKBKB(10), IKBKE(12), IL12A(3), IL12B(2), IL1B(4), IRAK1(7), IRAK4(3), IRF3(3), IRF5(6), IRF7(4), JUN(5), LBP(3), LY96(5), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K7(11), MAP3K8(2), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK9(5), MYD88(4), NFKB1(8), NFKB2(9), NFKBIA(1), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), RAC1(1), RELA(7), RIPK1(3), SPP1(4), STAT1(11), TBK1(8), TICAM1(8), TIRAP(1), TLR1(8), TLR2(4), TLR3(6), TLR5(11), TLR6(4), TLR7(6), TLR8(13), TLR9(15), TNF(3), TOLLIP(6), TRAF3(7), TRAF6(6)	48105117	472	167	454	153	133	59	63	96	118	3	0.252	1.000	1.000
228	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(3), BDKRB2(3), CALM1(2), CALM2(3), CALM3(1), CAV1(5), CHRM1(6), CHRNA1(7), FLT1(19), FLT4(31), KDR(17), NOS3(15), PDE2A(16), PDE3A(19), PDE3B(23), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKG1(12), PRKG2(15), RYR2(106), SLC7A1(9), SYT1(5), TNNI1(1)	23680532	361	164	340	116	105	45	44	85	81	1	0.189	1.000	1.000
229	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(3), AKT1(3), AKT2(10), AKT3(8), APAF1(8), ATM(49), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CAPN1(7), CAPN2(10), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CASP9(3), CFLAR(1), CHUK(5), CSF2RB(12), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(5), IRAK1(7), IRAK2(11), IRAK3(9), IRAK4(3), MYD88(4), NFKB1(8), NFKB2(9), NFKBIA(1), NTRK1(9), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RELA(7), RIPK1(3), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(9), TRADD(2), TRAF2(4)	46435307	489	163	461	119	135	64	49	92	142	7	0.00300	1.000	1.000
230	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(40), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADIPOQ(5), ADIPOR1(5), ADIPOR2(6), AGRP(2), AKT1(3), AKT2(10), AKT3(8), CAMKK1(5), CAMKK2(2), CD36(5), CHUK(5), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), G6PC2(1), IKBKB(10), IRS1(27), IRS2(10), IRS4(25), JAK1(19), JAK2(12), JAK3(12), LEP(3), LEPR(14), MAPK10(4), MAPK8(6), MAPK9(5), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NPY(2), PCK1(12), PCK2(10), POMC(9), PPARA(7), PPARGC1A(11), PRKAA1(7), PRKAA2(10), PRKAB2(4), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKCQ(14), PTPN11(8), RELA(7), RXRA(13), RXRB(5), RXRG(7), SLC2A1(8), SLC2A4(5), SOCS3(3), STAT3(7), STK11(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4), TYK2(12)	48232201	545	163	525	161	171	67	57	111	131	8	0.0559	1.000	1.000
231	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(2), ACTR3(2), AKT1(3), AKT2(10), AKT3(8), ANGPTL2(6), ARHGAP1(8), ARHGAP4(4), ARHGEF11(25), BTK(4), CDC42(3), CFL1(1), CFL2(1), GDI1(5), GDI2(6), INPPL1(27), ITPR1(34), ITPR2(33), ITPR3(44), LIMK1(6), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDK1(3), PIK3CD(15), PIK3CG(24), PIK3R1(12), PITX2(5), PPP1R13B(15), RACGAP1(8), RHO(9), ROCK1(20), ROCK2(16), RPS4X(2), SAG(4), WASF1(8), WASL(5)	39341783	463	163	434	126	144	54	62	79	115	9	0.0188	1.000	1.000
232	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(49), CCNA1(10), CCNB1(3), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(5), CDK2(4), CDK4(2), CDKN1A(5), CDKN1B(1), CDKN2B(1), CDKN2C(1), CDKN2D(4), CREB3L1(5), CREB3L3(6), CREB3L4(3), E2F1(4), E2F2(5), E2F3(3), E2F4(2), E2F5(4), GBA2(6), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), MNAT1(3), MYC(6), MYT1(22), NACA(19), PCNA(2), POLA2(4), POLE(34), POLE2(5), PRIM1(2), RB1(14), RBL1(12), RPA1(3), RPA2(4), RPA3(1), TFDP1(5), TFDP2(4), TNXB(68), WEE1(6)	44454282	424	160	406	116	130	57	51	74	108	4	0.0222	1.000	1.000
233	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ADCY4(9), ADCY6(18), ADCY8(37), CACNA1A(34), CACNA1B(32), GNAS(38), GNAT3(5), GNB1(2), GNB3(2), GNG13(3), GRM4(15), ITPR3(44), KCNB1(16), PDE1A(7), PLCB2(8), PRKACA(6), PRKACB(6), PRKACG(9), PRKX(6), SCNN1A(3), SCNN1B(9), SCNN1G(6), TAS1R1(9), TAS1R2(14), TAS1R3(12), TAS2R1(4), TAS2R13(4), TAS2R14(7), TAS2R16(7), TAS2R3(3), TAS2R38(6), TAS2R39(3), TAS2R4(4), TAS2R40(2), TAS2R41(1), TAS2R42(6), TAS2R43(3), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R60(3), TAS2R7(4), TAS2R8(4), TAS2R9(3), TRPM5(8)	32963160	427	160	411	147	151	53	54	91	77	1	0.301	1.000	1.000
234	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(3), AKT2(10), AKT3(8), BCL10(2), BLNK(5), BTK(4), CARD11(27), CD19(5), CD22(5), CD72(1), CD79A(8), CD79B(3), CD81(6), CHUK(5), CR2(25), FCGR2B(3), FOS(1), GSK3B(6), HRAS(1), IFITM1(4), IKBKB(10), INPP5D(8), JUN(5), LILRB3(6), LYN(7), MALT1(3), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(4), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTPN6(6), RAC1(1), RAC2(2), RAC3(4), RASGRP3(6), SYK(9), VAV1(13), VAV2(13), VAV3(14)	42069557	490	159	458	136	159	64	61	89	115	2	0.00664	1.000	1.000
235	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(4), BRAF(18), CHUK(5), CREB1(4), DAXX(11), ELK1(4), FOS(1), GRB2(4), HRAS(1), IKBKB(10), JUN(5), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP3K1(16), MAP3K10(13), MAP3K11(9), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K6(10), MAP3K7(11), MAP3K8(2), MAP3K9(5), MAP4K1(4), MAP4K2(10), MAP4K3(5), MAP4K4(13), MAP4K5(4), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK4(8), MAPK6(3), MAPK7(8), MAPK8(6), MAPK9(5), MAPKAPK2(3), MAPKAPK3(5), MAPKAPK5(4), MAX(3), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MKNK1(5), MKNK2(8), MYC(6), NFKB1(8), NFKBIA(1), PAK1(5), PAK2(12), RAC1(1), RAF1(9), RELA(7), RIPK1(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KA5(5), RPS6KB1(6), RPS6KB2(9), SHC1(7), SP1(5), STAT1(11), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TRADD(2), TRAF2(4)	54755489	537	158	515	152	154	71	61	90	157	4	0.0458	1.000	1.000
236	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(3), AKT2(10), AKT3(8), BAD(4), CASP9(3), CDC42(3), HRAS(1), KDR(17), MAP2K2(3), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPKAPK2(3), MAPKAPK3(5), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NOS3(15), NRAS(4), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCG1(22), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKCA(8), PRKCG(17), PTGS2(7), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SH2D2A(7), SHC2(3), SPHK1(10), SPHK2(8), SRC(5)	39938391	471	156	446	118	168	57	57	85	103	1	0.000120	1.000	1.000
237	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(5), ADAM17(9), ATP6AP1(6), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), CASP3(2), CCL5(3), CDC42(3), CHUK(5), CSK(8), EGFR(19), F11R(2), GIT1(4), HBEGF(2), IGSF5(5), IKBKB(10), JAM2(2), JAM3(6), JUN(5), LYN(7), MAP2K4(9), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK8(6), MAPK9(5), MET(10), NFKB1(8), NFKB2(9), NFKBIA(1), NOD1(13), PAK1(5), PLCG1(22), PLCG2(19), PTPN11(8), PTPRZ1(32), RAC1(1), RELA(7), SRC(5), TCIRG1(6), TJP1(26)	40573388	409	155	400	125	104	63	46	91	103	2	0.175	1.000	1.000
238	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2(4), BCR(14), BLNK(5), BTK(4), CD19(5), CD22(5), CD81(6), CR2(25), CSK(8), DAG1(13), FLOT2(9), GRB2(4), GSK3A(4), GSK3B(6), INPP5D(8), ITPR1(34), ITPR2(33), ITPR3(44), LYN(7), MAP4K1(4), MAPK1(3), MAPK3(3), NFATC1(16), NFATC2(26), NR0B2(3), PDK1(3), PIK3CD(15), PIK3R1(12), PLCG2(19), PPP1R13B(15), PPP3CA(13), PPP3CB(6), PPP3CC(6), PTPRC(21), RAF1(9), SHC1(7), SOS1(9), SOS2(18), SYK(9), VAV1(13)	42066500	493	154	463	144	160	61	51	101	116	4	0.0243	1.000	1.000
239	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(5), CDC40(8), CLK2(15), CLK3(13), CLK4(5), COL2A1(18), CPSF1(28), CPSF2(7), CPSF3(3), CPSF4(2), CSTF1(10), CSTF2(5), CSTF2T(12), CSTF3(9), DDIT3(5), DDX1(11), DDX20(3), DHX15(13), DHX16(9), DHX38(14), DHX8(18), DHX9(13), DICER1(10), DNAJC8(5), FUS(2), GIPC1(6), METTL3(2), NCBP1(7), NCBP2(3), NONO(5), NUDT21(3), NXF1(5), PABPN1(4), PAPOLA(7), PHF5A(1), POLR2A(24), PPM1G(4), PRPF18(2), PRPF3(8), PRPF4(7), PRPF4B(13), PRPF8(18), PSKH1(7), PTBP1(10), PTBP2(4), RBM17(2), RBM5(9), RNGTT(4), RNMT(9), RNPS1(1), SF3A1(6), SF3A2(2), SF3A3(2), SF3B1(13), SF3B2(16), SF3B4(9), SNRPA(7), SNRPA1(5), SNRPB(2), SNRPB2(2), SNRPD1(2), SNRPD2(5), SNRPD3(4), SNRPE(2), SNRPG(1), SNRPN(10), SPOP(4), SRPK1(8), SRPK2(8), SRRM1(17), SUPT5H(16), U2AF1(5), U2AF2(15), XRN2(15)	62004493	584	153	561	130	182	72	88	86	154	2	0.000598	1.000	1.000
240	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(10), AKT3(8), ANKRD6(9), APC(53), AXIN1(15), AXIN2(20), CER1(3), CSNK1A1(5), CTNNB1(27), DACT1(10), DKK1(12), DKK2(8), DKK3(4), DKK4(5), DVL1(8), FSTL1(3), GSK3A(4), GSK3B(6), LRP1(54), MVP(11), NKD1(8), NKD2(2), PIN1(2), PSEN1(5), PTPRA(15), SENP2(7), SFRP1(7), TSHB(3), WIF1(3)	23600918	330	153	305	89	95	35	45	62	85	8	0.0713	1.000	1.000
241	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	68	AKT1(3), AKT2(10), AKT3(8), BTK(4), FCER1A(5), FYN(9), GRB2(4), HRAS(1), IL13(4), IL3(1), IL4(4), INPP5D(8), LAT(3), LCP2(10), LYN(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK9(5), MS4A2(2), NRAS(4), PDK1(3), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCG1(22), PLCG2(19), PRKCA(8), PRKCD(10), PRKCE(14), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SOS1(9), SOS2(18), SYK(9), TNF(3), VAV1(13), VAV2(13), VAV3(14)	38826598	446	152	430	123	140	56	60	89	99	2	0.0110	1.000	1.000
242	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	58	AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2L1(1), CDC42(3), CDK2(4), CDKN1B(1), CREB1(4), CREB5(7), EBP(2), F2RL2(4), GAB1(4), GRB2(4), GSK3A(4), GSK3B(6), IFI27(1), IGF1(2), INPPL1(27), IRS1(27), IRS2(10), IRS4(25), MET(10), MYC(6), NOLC1(12), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PARD3(17), PDK1(3), PIK3CD(15), PPP1R13B(15), PREX1(21), PTK2(11), PTPN1(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SLC2A4(5), SOS1(9), SOS2(18), TSC1(10), TSC2(14), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3)	41445897	441	151	418	127	139	58	50	70	121	3	0.0590	1.000	1.000
243	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(14), AMY2A(7), ENPP1(7), ENPP3(12), GAA(8), GANAB(19), GBE1(7), GCK(9), GPI(6), GUSB(10), GYS1(8), GYS2(9), HK1(17), HK2(12), HK3(11), MGAM(19), PGM1(3), PGM3(13), PYGB(14), PYGL(11), PYGM(14), RNPC3(1), SI(35), UCHL1(3), UCHL3(4), UGDH(8), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5), UXS1(8)	32668349	339	147	317	107	86	39	44	84	85	1	0.322	1.000	1.000
244	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(5), APC(53), ATF2(4), AXIN1(15), BMP10(6), BMP2(7), BMP4(6), BMP5(11), BMP7(7), BMPR1A(12), BMPR2(21), CHRD(10), CTNNB1(27), DVL1(8), FZD1(11), GATA4(4), GSK3B(6), MAP3K7(11), MEF2C(5), MYL2(9), NKX2-5(7), NOG(2), NPPA(2), NPPB(3), RFC1(14), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR3(9)	20368412	304	146	286	80	75	28	35	56	103	7	0.102	1.000	1.000
245	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(4), AK3(5), CAD(20), CANT1(5), CTPS2(3), DCK(4), DCTD(1), DHODH(4), DPYD(20), DPYS(8), DUT(3), ENTPD1(4), ENTPD3(6), ENTPD4(13), ENTPD5(2), ENTPD6(6), ENTPD8(7), ITPA(1), NME2(3), NME4(2), NME6(3), NME7(1), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT2(5), PNPT1(5), POLA1(8), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(7), RFC5(2), RRM1(5), RRM2(3), RRM2B(4), TK1(1), TK2(4), TXNRD1(10), TXNRD2(4), TYMS(1), UCK1(6), UCK2(1), UMPS(5), UPB1(6), UPP1(2), UPP2(7), UPRT(6), ZNRD1(2)	47451760	456	145	441	130	146	52	64	85	109	0	0.0225	1.000	1.000
246	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(9), APH1A(1), CREBBP(46), CTBP1(5), CTBP2(8), DLL1(16), DLL3(9), DLL4(5), DTX1(18), DTX2(6), DTX3(7), DTX3L(2), DTX4(12), DVL1(8), DVL2(10), DVL3(15), EP300(27), HDAC1(9), HDAC2(6), HES1(1), JAG1(16), JAG2(17), LFNG(2), MAML1(6), MAML2(12), MAML3(9), MFNG(1), NCOR2(40), NCSTN(12), NOTCH1(31), NOTCH2(33), NOTCH3(26), NOTCH4(22), NUMB(3), NUMBL(5), PSEN1(5), PSEN2(3), PSENEN(2), PTCRA(2), RBPJ(7), RBPJL(9), RFNG(3), SNW1(7)	40371949	493	145	472	169	167	63	63	78	119	3	0.216	1.000	1.000
247	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(8), ATM(49), ATR(28), BAI1(20), BAX(1), BID(2), CASP3(2), CASP9(3), CCNB1(3), CCNB3(21), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNG2(1), CD82(3), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CHEK1(6), CHEK2(10), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(5), IGF1(2), IGFBP3(5), MDM2(8), MDM4(4), PERP(3), PPM1D(9), RCHY1(1), RFWD2(8), RPRM(6), RRM2(3), RRM2B(4), SERPINB5(3), SERPINE1(3), SESN1(2), SESN2(2), SESN3(5), SFN(1), SIAH1(3), STEAP3(9), THBS1(17), TNFRSF10B(2), TP53I3(1), TP73(6), TSC2(14), ZMAT3(4)	36271637	322	144	309	92	94	42	40	65	77	4	0.0948	1.000	1.000
248	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(18), CPEB1(6), EGFR(19), ERBB2(23), ETS1(8), ETS2(4), ETV6(9), ETV7(5), FMN2(44), GRB2(4), MAPK1(3), MAPK3(3), NOTCH1(31), NOTCH2(33), NOTCH3(26), NOTCH4(22), PIWIL1(6), PIWIL2(10), PIWIL3(6), PIWIL4(9), RAF1(9), SOS1(9), SOS2(18), SPIRE1(9), SPIRE2(6)	28261531	340	144	319	107	102	45	35	81	76	1	0.292	1.000	1.000
249	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(53), AR(24), ASAH1(4), BRAF(18), CAMP(3), CCL13(1), CCL15(2), CCL16(1), DAG1(13), EGFR(19), GNA11(6), GNA15(4), GNAI1(3), GNAQ(3), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), MAPK10(4), MAPK14(2), PHKA2(15), PIK3CD(15), PIK3R1(12), PITX2(5), PTX3(3), RAF1(9), SRC(5)	29976777	384	144	362	119	116	36	58	80	86	8	0.150	1.000	1.000
250	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(4), IMPA1(7), IMPA2(2), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPP5B(10), INPP5E(8), INPPL1(27), IPMK(2), ISYNA1(4), ITPK1(6), ITPKA(2), ITPKB(14), MINPP1(6), MIOX(6), OCRL(10), PI4KA(22), PI4KB(10), PIK3C3(16), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PTPMT1(1), SYNJ1(11), SYNJ2(20)	41741194	455	143	428	116	157	58	55	84	98	3	0.00102	1.000	1.000
251	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(4), AGT(4), AKT1(3), CALM1(2), CALM2(3), CALM3(1), CALR(2), CAMK1(3), CAMK1G(8), CAMK4(10), CREBBP(46), CSNK1A1(5), EDN1(4), ELSPBP1(3), F2(11), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(6), HAND1(5), HAND2(7), HRAS(1), IGF1(2), LIF(4), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), MEF2C(5), MYH2(39), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NKX2-5(7), NPPA(2), PIK3R1(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RAF1(9), RPS6KB1(6), SYT1(5)	28015461	368	143	350	102	125	42	45	63	92	1	0.00715	1.000	1.000
252	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR1(1), AGTR2(4), ATP8A1(9), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), CCKAR(7), CCKBR(16), CCR1(7), CCR10(3), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CX3CR1(4), CXCR3(2), CXCR6(2), EDNRA(4), FPR1(8), GALR1(6), GALR2(11), GALR3(4), GALT(3), GHSR(8), GNB2L1(3), GNRHR(5), GRPR(6), MC1R(6), MC2R(3), MC3R(11), MC4R(6), MC5R(6), NMBR(3), NPY1R(5), NPY2R(7), NPY5R(4), NTSR1(10), NTSR2(5), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OXTR(8), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), TAC4(3), TACR1(4), TACR2(2), TACR3(15), TRHR(7), TSHR(12)	28571410	387	141	373	158	155	42	63	65	61	1	0.486	1.000	1.000
253	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(3), APOA1(8), CD36(5), CITED2(4), CPT1B(7), CREBBP(46), DUSP1(3), DUT(3), EHHADH(4), EP300(27), HSD17B4(7), HSPA1A(4), JUN(5), LPL(9), MAPK1(3), MAPK3(3), ME1(1), MYC(6), NCOA1(20), NCOR1(30), NCOR2(40), NFKBIA(1), NR0B2(3), NR1H3(5), NR2F1(11), NRIP1(18), PDGFA(2), PIK3R1(12), PPARA(7), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PTGS2(7), RB1(14), RELA(7), RXRA(13), SP1(5), STAT5A(10), STAT5B(13), TNF(3)	35744507	416	141	401	119	113	51	52	80	115	5	0.0692	1.000	1.000
254	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(10), AKT3(8), ASAH1(4), BRAF(18), DAG1(13), DRD2(10), EGFR(19), EPHB2(15), GRB2(4), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), PI3(2), PIK3CB(13), PITX2(5), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), RAF1(9), RGS20(7), SHC1(7), SOS1(9), SOS2(18), SRC(5), STAT3(7), TERF2IP(5)	34279235	412	139	390	134	138	54	51	82	83	4	0.245	1.000	1.000
255	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), AOX1(14), CARM1(8), COMT(5), DBH(7), DCT(16), ECH1(5), ESCO1(10), ESCO2(10), FAH(7), GOT1(3), GOT2(2), GSTZ1(2), HEMK1(1), HGD(6), HPD(4), LCMT1(1), LCMT2(11), MAOA(4), MAOB(3), METTL6(5), MIF(1), NAT6(4), PNPLA3(4), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SH3GLB1(3), TAT(5), TH(7), TPO(27), TYR(15), TYRP1(9), WBSCR22(5)	33956479	330	137	307	84	82	30	39	75	101	3	0.0564	1.000	1.000
256	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AGK(6), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), AKR1A1(3), AKR1B1(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CEL(16), DAK(7), DGAT1(10), DGAT2(2), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), GK(4), GK2(9), GLA(3), GLB1(7), GPAM(11), LCT(24), LIPA(3), LIPC(5), LIPF(7), LIPG(4), LPL(9), MGLL(2), PNLIP(6), PNLIPRP1(3), PNPLA3(4), PPAP2A(3), PPAP2B(2), PPAP2C(6)	34304628	356	137	336	101	98	40	49	70	97	2	0.0764	1.000	1.000
257	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(1), APAF1(8), ARHGDIB(1), BAG4(5), BCL2(4), BID(2), BIRC2(7), BIRC3(10), CASP2(3), CASP3(2), CASP6(1), CASP7(4), CASP9(3), CFLAR(1), CHUK(5), CRADD(6), DAXX(11), DFFA(4), DFFB(3), FADD(3), GSN(12), LMNA(11), LMNB1(4), LMNB2(6), MAP3K1(16), MAP3K5(10), MAPK8(6), MDM2(8), NFKB1(8), NFKBIA(1), NUMA1(26), PAK2(12), PRKCD(10), PRKDC(56), PSEN1(5), PSEN2(3), PTK2(11), RASA1(19), RB1(14), RELA(7), RIPK1(3), SPTAN1(22), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(4), TRAF2(4)	39412776	376	136	361	115	99	50	59	63	101	4	0.296	1.000	1.000
258	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), ASCC3(37), ATP13A2(16), DDX18(14), DDX19A(5), DDX23(12), DDX4(9), DDX41(9), DDX47(1), DDX50(12), DDX51(7), DDX52(7), DDX54(17), DDX55(5), DDX56(8), DHX58(11), ENTPD7(10), EP400(47), ERCC2(9), ERCC3(8), FPGS(7), GCH1(1), GGH(2), IFIH1(10), MOV10L1(9), NUDT5(1), NUDT8(1), QDPR(5), RAD54B(3), RAD54L(4), RUVBL2(9), SETX(24), SKIV2L2(13), SMARCA2(31), SMARCA5(10), SPR(2)	36810663	409	136	396	122	135	45	52	80	95	2	0.150	1.000	1.000
259	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(3), AKT2(10), AKT3(8), BCR(14), BTK(4), CD19(5), DAPP1(1), FLOT2(9), GAB1(4), ITPR1(34), ITPR2(33), ITPR3(44), LYN(7), NR0B2(3), PDK1(3), PHF11(5), PITX2(5), PLCG2(19), PPP1R13B(15), PREX1(21), PTPRC(21), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SAG(4), SYK(9), TEC(4), VAV1(13)	30226449	331	136	318	106	115	40	35	68	70	3	0.186	1.000	1.000
260	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(9), AKT1(3), APC(53), ASAH1(4), CAMP(3), CAV3(2), DAG1(13), DLG4(4), EPHB2(15), GNAI1(3), GNAQ(3), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), PITX2(5), PTX3(3), RAC1(1), RHO(9), RYR1(68)	26855057	339	136	327	111	121	35	43	64	69	7	0.120	1.000	1.000
261	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(16), AR(24), ESR1(8), ESR2(9), ESRRA(2), HNF4A(7), NPM1(1), NR0B1(5), NR1D1(9), NR1D2(8), NR1H2(7), NR1H3(5), NR1I2(9), NR1I3(3), NR2C2(6), NR2E1(4), NR2F1(11), NR2F2(5), NR2F6(5), NR3C1(9), NR4A1(5), NR4A2(15), NR5A1(9), NR5A2(4), PGR(18), PPARA(7), PPARD(8), PPARG(4), RARA(4), RARB(10), RARG(2), ROR1(11), RORA(7), RORC(7), RXRA(13), RXRB(5), RXRG(7), THRA(7), THRB(4), VDR(4)	24589043	304	135	294	109	109	41	35	68	50	1	0.418	1.000	1.000
262	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(10), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(6), CDC42(3), CFL1(1), CFL2(1), FLNA(28), FLNC(38), FSCN1(6), FSCN3(13), GDI1(5), GDI2(6), LIMK1(6), MYH2(39), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PFN1(1), PFN2(1), RHO(9), ROCK1(20), ROCK2(16), RPS4X(2), VASP(2), WASF1(8), WASL(5)	28057152	319	135	313	109	114	37	44	54	66	4	0.230	1.000	1.000
263	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(16), ACSS2(12), ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH7A1(2), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), G6PC2(1), GALM(4), GAPDH(3), GAPDHS(5), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKL(8), PFKM(2), PFKP(21), PGAM1(1), PGAM2(5), PGAM4(2), PGK1(4), PGK2(3), PGM1(3), PGM3(13), PKLR(9), TPI1(3)	34076688	369	134	348	117	97	66	46	79	81	0	0.116	1.000	1.000
264	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(3), ACADM(7), ACOX1(3), ACOX2(8), ACOX3(13), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADIPOQ(5), ANGPTL4(3), APOA1(8), APOA5(7), AQP7(8), CD36(5), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), CYP27A1(6), CYP4A11(4), CYP4A22(5), CYP7A1(7), CYP8B1(6), DBI(1), EHHADH(4), FABP2(1), FABP3(1), FABP4(1), FABP5(2), FABP6(4), FABP7(1), FADS2(4), GK(4), GK2(9), HMGCS2(4), ILK(9), LPL(9), ME1(1), MMP1(3), NR1H3(5), OLR1(4), PCK1(12), PCK2(10), PDPK1(1), PLTP(5), PPARA(7), PPARD(8), PPARG(4), RXRA(13), RXRB(5), RXRG(7), SCD(1), SCP2(5), SLC27A1(4), SLC27A2(8), SLC27A4(10), SLC27A5(5), SLC27A6(11), SORBS1(12), UBC(9), UCP1(4)	38366394	380	134	371	122	129	45	50	80	76	0	0.221	1.000	1.000
265	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(3), AKT2(10), AKT3(8), BRAF(18), CAB39(2), EIF4B(5), EIF4EBP1(4), FIGF(5), HIF1A(5), IGF1(2), MAPK1(3), MAPK3(3), PDPK1(1), PGF(3), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PRKAA1(7), PRKAA2(10), RHEB(2), RICTOR(25), RPS6(1), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), RPS6KB2(9), STK11(6), TSC1(10), TSC2(14), ULK1(20), ULK2(11), ULK3(2), VEGFB(2), VEGFC(12)	28971322	333	133	313	98	113	35	52	52	78	3	0.196	1.000	1.000
266	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(5), CD28(1), CSK(8), CTLA4(4), DAG1(13), EPHB2(15), GRAP2(5), GRB2(4), ITK(5), ITPKA(2), ITPKB(14), LAT(3), LCK(4), LCP2(10), MAPK1(3), NCK1(6), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PLCG1(22), PTPRC(21), RAF1(9), RASGRP1(7), RASGRP2(8), RASGRP3(6), RASGRP4(6), SOS1(9), SOS2(18), VAV1(13), ZAP70(13)	31713820	331	133	318	101	108	35	39	71	76	2	0.239	1.000	1.000
267	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(28), ACACB(40), ACAT1(6), ACAT2(5), ACOT12(7), ACSS1(16), ACSS2(12), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), DLAT(8), DLD(10), GLO1(2), GRHPR(2), HAGH(5), HAGHL(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), LDHD(2), MDH1(3), ME1(1), ME2(7), ME3(7), PC(18), PCK1(12), PCK2(10), PDHA1(1), PDHA2(11), PDHB(4), PKLR(9)	27388341	315	130	296	100	86	51	37	59	81	1	0.327	1.000	1.000
268	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), F10(8), F11(5), F12(3), F2(11), F2R(6), F5(22), F8(29), F9(9), FGA(12), FGB(6), FGG(5), KLKB1(6), PROC(4), PROS1(11), SERPINC1(5), SERPING1(8)	26059769	265	130	260	78	61	45	32	70	55	2	0.113	1.000	1.000
269	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(15), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), CDIPT(1), CDS1(5), CDS2(3), CHAT(6), CHKA(2), CHKB(3), CHPT1(4), CRLS1(1), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), ESCO1(10), ESCO2(10), ETNK1(3), ETNK2(2), GNPAT(4), GPAM(11), GPD1(8), GPD1L(4), GPD2(8), LCAT(4), LYPLA1(1), LYPLA2(2), NAT6(4), PCYT1A(9), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(5), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLD1(22), PLD2(19), PNPLA3(4), PPAP2A(3), PPAP2B(2), PPAP2C(6), PTDSS1(6), PTDSS2(3), SH3GLB1(3)	38117658	347	129	337	98	111	32	49	66	87	2	0.0574	1.000	1.000
270	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(5), CAD(20), CANT1(5), CTPS2(3), DCK(4), DCTD(1), DHODH(4), DPYD(20), DPYS(8), DUT(3), ENTPD1(4), ITPA(1), NME2(3), NT5E(5), NT5M(6), NUDT2(5), POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14), RRM1(5), RRM2(3), TK1(1), TK2(4), TXNRD1(10), TYMS(1), UCK1(6), UCK2(1), UMPS(5), UNG(2), UPB1(6), UPP1(2)	33571699	328	129	318	104	90	45	49	61	83	0	0.237	1.000	1.000
271	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(6), DAG1(13), DGKA(9), ETFA(2), GCA(3), ITGA9(9), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), MAPK1(3), MAPK3(3), NR1I3(3), PAK1(5), PDE3A(19), PDE3B(23), PI3(2), PIK3C2G(14), PIK3CD(15), PIK3R1(12), PSME1(3), RIPK3(5), RPS4X(2), SGCB(5), VASP(2)	26751547	292	129	280	95	87	38	42	56	65	4	0.192	1.000	1.000
272	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(4), BRAF(18), CAMP(3), CREB1(4), CREB5(7), CREBBP(46), CRKL(2), DAG1(13), EGR1(12), EGR2(9), EGR3(9), EGR4(7), ELK1(4), FRS2(5), GNAQ(3), JUN(5), MAP1B(25), MAP2K4(9), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), NTRK1(9), OPN1LW(10), PIK3C2G(14), PIK3CD(15), PIK3R1(12), PTPN11(8), RPS6KA3(6), SHC1(7), SRC(5), TERF2IP(5), TH(7)	28364373	331	129	313	107	101	42	40	60	86	2	0.222	1.000	1.000
273	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(13), EEF1A2(7), EEF1B2(4), EEF1D(3), EEF1G(4), EEF2(17), EEF2K(11), EIF1AX(2), EIF1AY(1), EIF2AK1(5), EIF2AK2(6), EIF2AK3(21), EIF2B1(4), EIF2B2(4), EIF2B3(9), EIF2B4(11), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(4), EIF4EBP2(4), EIF4G1(25), EIF4G3(22), EIF5(6), EIF5A(5), EIF5B(28), ETF1(7), GSPT2(9), PABPC1(10), PABPC3(15), PAIP1(3), SLC35A4(9)	25609736	295	129	279	60	73	41	45	61	72	3	0.000497	1.000	1.000
274	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	47	ABL1(10), ACTB(8), ACTG1(1), ARHGEF2(13), CD14(1), CDC42(3), CLDN1(4), CTNNB1(27), CTTN(12), EZR(5), FYN(9), HCLS1(3), ITGB1(11), KRT18(3), LY96(5), NCK1(6), NCK2(8), NCL(7), OCLN(8), PRKCA(8), ROCK1(20), ROCK2(16), TLR5(11), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9), WAS(4), WASL(5), YWHAQ(4), YWHAZ(3)	28460302	309	128	291	93	91	46	35	65	70	2	0.0626	1.000	1.000
275	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	47	ABL1(10), ACTB(8), ACTG1(1), ARHGEF2(13), CD14(1), CDC42(3), CLDN1(4), CTNNB1(27), CTTN(12), EZR(5), FYN(9), HCLS1(3), ITGB1(11), KRT18(3), LY96(5), NCK1(6), NCK2(8), NCL(7), OCLN(8), PRKCA(8), ROCK1(20), ROCK2(16), TLR5(11), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9), WAS(4), WASL(5), YWHAQ(4), YWHAZ(3)	28460302	309	128	291	93	91	46	35	65	70	2	0.0626	1.000	1.000
276	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(8), BAD(4), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BCL2L11(4), BID(2), BIRC2(7), BIRC3(10), BIRC5(3), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP9(3), CHUK(5), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), GZMB(2), HELLS(7), IKBKB(10), IRF1(5), IRF3(3), IRF4(8), IRF5(6), IRF6(8), IRF7(4), JUN(5), LTA(4), MAP2K4(9), MAP3K1(16), MAPK10(4), MDM2(8), MYC(6), NFKB1(8), NFKBIA(1), NFKBIB(8), NFKBIE(1), PLEKHG5(9), PRF1(13), RELA(7), RIPK1(3), TNF(3), TNFRSF10B(2), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(4), TNFRSF25(5), TNFSF10(9), TP73(6), TRADD(2), TRAF1(4), TRAF2(4), TRAF3(7)	32004253	312	126	299	88	84	45	39	56	85	3	0.0494	1.000	1.000
277	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(14), ATP4A(20), ATP4B(4), ATP5A1(3), ATP5B(9), ATP5C1(5), ATP5F1(3), ATP5G2(2), ATP5G3(2), ATP5J(3), ATP5J2(1), ATP5L(1), ATP6AP1(6), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), COX10(2), COX15(5), COX4I1(4), COX4I2(3), COX5B(1), COX6B1(2), COX7A1(1), COX7B(3), COX7C(1), COX8A(1), COX8C(4), CYC1(5), LHPP(3), NDUFA1(1), NDUFA10(3), NDUFA12(2), NDUFA13(2), NDUFA3(1), NDUFA8(6), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(1), NDUFB11(2), NDUFB2(1), NDUFB3(3), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFB8(2), NDUFB9(2), NDUFC2(2), NDUFS1(7), NDUFS2(6), NDUFS3(3), NDUFS4(3), NDUFS5(3), NDUFS6(4), NDUFS7(4), NDUFS8(2), NDUFV1(6), NDUFV2(1), PPA1(4), PPA2(3), SDHA(11), SDHB(4), SDHC(2), SDHD(1), TCIRG1(6), UQCRB(2), UQCRC1(3), UQCRC2(5), UQCRFS1(3), UQCRQ(1)	32029041	335	126	328	100	100	54	43	61	77	0	0.0635	1.000	1.000
278	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(8), AASDHPPT(1), AASS(10), ACAT1(6), ACAT2(5), AKR1B10(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), BBOX1(4), DLST(6), DOT1L(18), ECHS1(2), EHHADH(4), EHMT1(18), EHMT2(19), GCDH(7), HADH(2), HADHA(5), HSD17B4(7), HSD3B7(7), NSD1(27), OGDH(11), OGDHL(19), PIPOX(3), PLOD1(9), PLOD2(15), PLOD3(17), RDH11(1), RDH12(3), RDH13(7), SETD1A(24), SETD7(3), SETDB1(17), SHMT1(2), SHMT2(11), SPCS1(2), SPCS3(3), SUV39H1(6), SUV39H2(2), TMLHE(5)	33949841	379	126	350	107	117	44	51	65	101	1	0.0646	1.000	1.000
279	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	34	ACTA1(4), ACTN1(7), ACTN2(26), BCAR1(10), BCR(14), CAPN1(7), CAPNS1(3), CAPNS2(2), CAV1(5), CRKL(2), CSK(8), FYN(9), GRB2(4), HRAS(1), ITGA1(7), ITGB1(11), JUN(5), MAP2K2(3), MAPK1(3), MAPK3(3), MAPK8(6), PPP1R12B(16), PTK2(11), PXN(6), RAF1(9), RAP1A(3), ROCK1(20), SHC1(7), SOS1(9), SRC(5), TLN1(28), VCL(11), ZYX(7)	27119932	272	126	263	79	107	28	30	53	52	2	0.0359	1.000	1.000
280	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	12	CASR(19), GABBR1(18), GPRC5A(1), GPRC5B(14), GPRC5C(9), GPRC5D(2), GRM1(43), GRM2(27), GRM3(22), GRM4(15), GRM7(27), GRM8(27)	11075010	224	125	216	78	88	23	31	48	34	0	0.215	1.000	1.000
281	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(3), BAK1(4), BAX(1), BFAR(5), BTK(4), CAD(20), CASP10(8), CASP3(2), CD7(5), CDK2AP1(1), CSNK1A1(5), DAXX(11), DEDD(3), DEDD2(3), DFFA(4), DIABLO(1), EGFR(19), EPHB2(15), FADD(3), FAF1(10), FAIM2(1), HSPB1(2), IL1A(2), MAP2K4(9), MAP3K1(16), MAP3K5(10), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MET(10), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR0B2(3), PFN1(1), PFN2(1), PTPN13(34), RALBP1(10), RIPK1(3), ROCK1(20), SMPD1(6), TPX2(7), TRAF2(4)	41054219	353	125	338	117	97	46	45	62	98	5	0.499	1.000	1.000
282	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(8), AANAT(2), ACAT1(6), ACAT2(5), ACMSD(6), AFMID(4), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AOC2(10), AOC3(13), AOX1(14), ASMT(5), CARM1(8), CAT(6), CYP1A1(7), CYP1A2(5), CYP1B1(4), ECHS1(2), EHHADH(4), GCDH(7), HAAO(1), HADH(2), HADHA(5), HEMK1(1), HSD17B4(7), INMT(4), KMO(6), KYNU(13), LCMT1(1), LCMT2(11), LNX1(5), MAOA(4), MAOB(3), METTL6(5), NFX1(5), OGDH(11), OGDHL(19), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), TDO2(9), TPH1(4), TPH2(10), WARS(4), WARS2(12), WBSCR22(5)	34869021	360	124	331	101	81	48	47	63	119	2	0.132	1.000	1.000
283	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	69	CALR(2), CANX(3), CD4(11), CD74(4), CD8A(4), CD8B(2), CIITA(20), CREB1(4), CTSB(3), CTSS(5), HLA-C(7), HLA-DMA(1), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(4), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), HLA-E(6), HLA-F(8), HLA-G(5), HSP90AA1(13), HSP90AB1(10), HSPA5(4), IFI30(3), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), KIR2DL3(4), KIR3DL1(10), KIR3DL2(3), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), LGMN(7), LTA(4), NFYB(1), NFYC(3), PDIA3(5), PSME1(3), PSME2(2), RFX5(12), RFXANK(6), RFXAP(2), TAP1(5), TAP2(10), TAPBP(7)	26013762	270	124	261	61	53	32	52	67	63	3	0.00430	1.000	1.000
284	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(3), AKT2(10), AKT3(8), BRD4(15), CAP1(2), CBL(5), CDC42(3), F2RL2(4), FLOT2(9), GRB2(4), GSK3A(4), GSK3B(6), INPPL1(27), IRS1(27), IRS2(10), IRS4(25), LNPEP(12), MAPK1(3), MAPK3(3), PARD3(17), PDK1(3), PIK3CD(15), PIK3R1(12), PTPN1(3), RAF1(9), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SERPINB6(4), SFN(1), SHC1(7), SLC2A4(5), SORBS1(12), SOS1(9), SOS2(18), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3)	32572879	346	124	328	98	117	49	32	53	92	3	0.0577	1.000	1.000
285	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(5), B3GALNT1(5), B3GALT1(3), B3GALT2(8), B3GALT4(8), B3GALT5(2), B3GNT1(4), B3GNT2(5), B3GNT3(3), B3GNT4(9), B3GNT5(11), B4GALNT1(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), B4GALT6(6), FUT1(5), FUT2(2), FUT3(4), FUT4(2), FUT5(3), FUT6(6), FUT7(3), FUT9(7), GBGT1(4), GCNT2(1), PIGA(3), PIGB(10), PIGC(6), PIGG(15), PIGK(3), PIGL(5), PIGM(4), PIGN(6), PIGO(10), PIGP(1), PIGQ(9), PIGS(4), PIGT(11), PIGV(7), PIGX(3), PIGZ(10), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7), ST3GAL5(2), ST3GAL6(6), ST6GALNAC3(6), ST6GALNAC4(3), ST6GALNAC5(9), ST6GALNAC6(4), ST8SIA1(12), ST8SIA5(8), UGCG(3)	28384348	312	123	290	109	100	32	33	61	85	1	0.784	1.000	1.000
286	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(4), CALM1(2), CALM2(3), CALM3(1), ELK1(4), FCER1A(5), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PAK2(12), PIK3R1(12), PLA2G4A(7), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), RAF1(9), SHC1(7), SOS1(9), SYK(9), SYT1(5), VAV1(13)	23113898	267	122	255	53	87	35	31	41	70	3	3.56e-05	1.000	1.000
287	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(7), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPPL1(27), ITPKA(2), ITPKB(14), MIOX(6), OCRL(10), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3CB(13), PIK3CG(24), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCG1(22), PLCG2(19)	24927158	294	122	272	73	90	40	43	51	68	2	0.0183	1.000	1.000
288	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRA2A(9), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), HRH1(5), HRH2(6), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14)	15089408	276	122	263	100	110	28	43	63	32	0	0.142	1.000	1.000
289	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(10), AKT3(8), ARHGEF11(25), BCL2(4), CDC42(3), DLG4(4), GNA13(7), LPA(21), MAP2K4(9), MAP3K1(16), MAP3K5(10), MAPK8(6), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(15), PI3(2), PIK3CB(13), PLD1(22), PLD2(19), PLD3(8), PTK2(11), RDX(7), ROCK1(20), ROCK2(16), SERPINA4(5), SRF(5), TBXA2R(9)	28780249	313	122	296	68	84	43	39	45	97	5	0.00156	1.000	1.000
290	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(2), CALM2(3), CALM3(1), CD3E(2), ELK1(4), FOS(1), FYN(9), GRB2(4), HRAS(1), JUN(5), LAT(3), LCK(4), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKBIA(1), PIK3R1(12), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), PTPN7(7), RAC1(1), RAF1(9), RASA1(19), RELA(7), SHC1(7), SOS1(9), SYT1(5), VAV1(13), ZAP70(13)	26314137	302	122	287	70	99	36	28	49	87	3	0.00131	1.000	1.000
291	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AKR1A1(3), AKR1B1(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), CEL(16), DGAT1(10), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), GK(4), GLA(3), GLB1(7), LCT(24), LIPC(5), LIPF(7), LIPG(4), LPL(9), PNLIP(6), PNLIPRP1(3), PPAP2A(3), PPAP2B(2), PPAP2C(6)	28172803	296	121	277	92	83	28	42	57	84	2	0.324	1.000	1.000
292	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(3), AGXT2(13), AKR1B10(6), ALAS1(5), ALAS2(14), AMT(4), AOC2(10), AOC3(13), BHMT(5), CBS(9), CHDH(6), CHKA(2), CHKB(3), CTH(3), DLD(10), DMGDH(7), GAMT(1), GARS(3), GATM(3), GCAT(5), GLDC(9), GNMT(4), HSD3B7(7), MAOA(4), MAOB(3), PEMT(1), PHGDH(5), PIPOX(3), PISD(5), PSAT1(7), PSPH(2), RDH11(1), RDH12(3), RDH13(7), SARDH(12), SARS(9), SARS2(9), SDS(4), SHMT1(2), SHMT2(11), TARS(11), TARS2(13)	24529564	257	121	249	82	79	35	36	46	60	1	0.283	1.000	1.000
293	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(16), CARM1(8), CCND1(2), CREBBP(46), EP300(27), ERCC3(8), ESR1(8), GRIP1(20), GTF2A1(3), GTF2E1(6), GTF2F1(6), HDAC1(9), HDAC2(6), HDAC3(7), HDAC4(29), HDAC5(13), HDAC6(9), MEF2C(5), NCOR2(40), NR0B1(5), NRIP1(18), PELP1(8), POLR2A(24), TBP(6)	26880867	329	120	313	81	108	46	40	54	77	4	0.00120	1.000	1.000
294	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(49), ATR(28), BRCA1(16), CCNB1(3), CDC25A(5), CDC25B(6), CDC25C(11), CDC34(2), CDKN1A(5), CDKN2D(4), CHEK1(6), CHEK2(10), EP300(27), MDM2(8), MYT1(22), PRKDC(56), RPS6KA1(9), WEE1(6), YWHAH(3), YWHAQ(4)	24075996	280	120	264	67	70	34	43	53	75	5	0.0250	1.000	1.000
295	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKM(2), PFKP(21), PGAM1(1), PGK1(4), PGM1(3), PGM3(13), PKLR(9), TPI1(3)	28639423	312	120	293	100	79	49	40	72	72	0	0.254	1.000	1.000
296	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKM(2), PFKP(21), PGAM1(1), PGK1(4), PGM1(3), PGM3(13), PKLR(9), TPI1(3)	28639423	312	120	293	100	79	49	40	72	72	0	0.254	1.000	1.000
297	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	23	AKT1(3), APC(53), AXIN1(15), CCND1(2), CD14(1), CTNNB1(27), DVL1(8), FZD1(11), GJA1(13), GNAI1(3), GSK3B(6), IRAK1(7), LBP(3), LEF1(5), LY96(5), MYD88(4), NFKB1(8), PDPK1(1), PIK3R1(12), PPP2CA(4), RELA(7), TIRAP(1), TOLLIP(6)	15438335	205	120	190	54	41	23	27	39	69	6	0.0889	1.000	1.000
298	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(3), AKT2(10), AKT3(8), BAD(4), BCR(14), BLNK(5), BTK(4), CD19(5), CSK(8), DAG1(13), EPHB2(15), GRB2(4), ITPKA(2), ITPKB(14), LYN(7), MAP2K2(3), MAPK1(3), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PI3(2), PIK3CD(15), PIK3R1(12), PLCG2(19), PPP1R13B(15), RAF1(9), SERPINA4(5), SHC1(7), SOS1(9), SOS2(18), SYK(9), VAV1(13)	29149138	300	120	283	93	97	34	31	62	74	2	0.273	1.000	1.000
299	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1C1(3), AKR1C2(1), AKR1C3(3), AKR1C4(5), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), CYP1A1(7), CYP1A2(5), CYP1B1(4), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2F1(9), CYP2S1(8), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), DHDH(5), EPHX1(10), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), MGST1(3), MGST2(3), MGST3(3), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7)	33511006	296	119	279	79	68	34	42	68	84	0	0.105	1.000	1.000
300	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(49), BMPR1B(9), CCND2(2), CDK4(2), CDKN1B(1), DMC1(8), EGR1(12), ESR2(9), GJA4(8), INHA(6), MLH1(8), MSH5(5), NCOR1(30), NR5A1(9), NRIP1(18), PGR(18), PRLR(5), PTGER2(7), SMPD1(6), VDR(4), ZP2(12)	18936561	228	119	215	55	57	32	30	41	64	4	0.0281	1.000	1.000
301	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(15), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPS(6), CDIPT(1), CDS1(5), CDS2(3), CHAT(6), CHKA(2), CHKB(3), CLC(2), CPT1B(7), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), ETNK1(3), GNPAT(4), GPD1(8), GPD2(8), LCAT(4), LYPLA1(1), LYPLA2(2), PAFAH2(4), PCYT1A(9), PCYT1B(6), PEMT(1), PISD(5), PLA2G2A(2), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB2(8), PLCG1(22), PLCG2(19), PPAP2A(3), PPAP2B(2), PPAP2C(6)	28513800	283	118	274	87	100	25	44	55	57	2	0.144	1.000	1.000
302	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(4), ARSD(5), ARSE(6), CARM1(8), CYP11B1(17), CYP11B2(8), CYP19A1(12), HEMK1(1), HSD11B1(4), HSD11B2(4), HSD17B1(4), HSD17B12(4), HSD17B2(3), HSD17B3(2), HSD17B7(5), HSD3B1(4), HSD3B2(2), LCMT1(1), LCMT2(11), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), SULT2B1(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), WBSCR22(5)	29329371	273	118	260	85	55	50	39	58	70	1	0.214	1.000	1.000
303	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(3), ATF2(4), CDC42(3), DLD(10), DUSP10(8), DUSP4(2), DUSP8(2), GAB1(4), GCK(9), IL1R1(4), JUN(5), MAP2K4(9), MAP2K5(1), MAP3K1(16), MAP3K10(13), MAP3K11(9), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K7(11), MAP3K9(5), MAPK10(4), MAPK7(8), MAPK8(6), MAPK9(5), MYEF2(8), NFATC3(5), NR2C2(6), PAPPA(29), SHC1(7), TRAF6(6), ZAK(8)	28638249	288	118	278	81	79	47	36	50	75	1	0.0795	1.000	1.000
304	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(2), ACAT1(6), ACAT2(5), ACMSD(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), AOC2(10), AOC3(13), AOX1(14), ASMT(5), CAT(6), CYP19A1(12), CYP1A1(7), CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2D6(13), CYP2E1(6), CYP2F1(9), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(4), CYP4B1(11), CYP51A1(9), ECHS1(2), EHHADH(4), GCDH(7), HAAO(1), HADHA(5), KMO(6), KYNU(13), MAOA(4), MAOB(3), SDS(4), TDO2(9), TPH1(4), WARS(4), WARS2(12)	31690684	347	118	323	94	93	44	37	66	106	1	0.0884	1.000	1.000
305	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(7), AARS2(15), ABAT(4), ACY3(3), ADSL(5), ADSS(6), ADSSL1(9), AGXT(3), AGXT2(13), ASL(5), ASNS(5), ASPA(2), ASRGL1(4), ASS1(10), CAD(20), CRAT(12), DARS(2), DARS2(4), DDO(6), DLAT(8), DLD(10), GAD1(8), GAD2(15), GOT1(3), GOT2(2), GPT(4), GPT2(3), NARS(5), NARS2(3), PC(18), PDHA1(1), PDHA2(11), PDHB(4)	22152893	230	117	220	80	74	32	28	41	54	1	0.495	1.000	1.000
306	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(7), AARS2(15), CARS(6), CARS2(7), DARS(2), DARS2(4), EARS2(3), EPRS(18), FARS2(9), FARSA(6), FARSB(3), GARS(3), HARS(9), HARS2(4), IARS(11), IARS2(12), KARS(7), LARS(9), LARS2(10), MARS(7), MARS2(5), MTFMT(2), NARS(5), NARS2(3), QARS(7), RARS(5), RARS2(6), SARS(9), SARS2(9), TARS(11), TARS2(13), VARS(23), VARS2(14), WARS(4), WARS2(12), YARS(8), YARS2(2)	31823951	290	117	282	79	86	36	48	54	65	1	0.0921	1.000	1.000
307	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(10), ADCY3(18), ADCY9(17), AK1(1), ARF1(5), ARF4(1), ARF6(1), ARL4D(1), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), ERO1L(2), GNAS(38), PDIA4(6), PLCG1(22), PLCG2(19), PRKCA(8), SEC61A1(4), SEC61A2(4), SEC61B(1), SEC61G(1), TRIM23(9)	21715043	267	117	254	69	101	33	32	48	53	0	0.00852	1.000	1.000
308	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(9), APC(53), AXIN1(15), BTRC(9), CTNNB1(27), DLL1(16), DVL1(8), FZD1(11), GSK3B(6), NOTCH1(31), PSEN1(5)	12236963	190	117	173	60	47	17	17	35	69	5	0.446	1.000	1.000
309	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	91	ANK2(48), B3GALT4(8), CDR1(4), DGKI(16), IL6ST(6), PIGK(3), RPL10(5), RPL11(1), RPL12(3), RPL13A(4), RPL14(2), RPL15(1), RPL17(1), RPL18(1), RPL18A(1), RPL19(1), RPL23(1), RPL24(2), RPL26(1), RPL27(1), RPL28(1), RPL29(2), RPL3(3), RPL31(2), RPL34(1), RPL35A(1), RPL36(1), RPL37(1), RPL38(1), RPL3L(3), RPL4(3), RPL5(3), RPL6(3), RPL7A(6), RPL8(3), RPL9(4), RPLP0(4), RPLP1(1), RPLP2(2), RPS10(1), RPS11(1), RPS13(2), RPS14(1), RPS15(2), RPS16(1), RPS18(1), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(1), RPS26(1), RPS27(1), RPS27A(4), RPS3(2), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), RPS6KB2(9), RPS7(1), RPS9(2), RPSA(5), SLC36A2(5), TBC1D10C(9), TSPAN9(3), UBA52(2), UBB(2), UBC(9)	29740848	269	117	258	91	72	30	43	55	68	1	0.857	1.000	1.000
310	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(5), CASP2(3), CASP3(2), CRADD(6), DFFA(4), DFFB(3), FADD(3), JUN(5), LMNA(11), LMNB1(4), LMNB2(6), MADD(18), MAP2K4(9), MAP3K1(16), MAP3K7(11), MAPK8(6), PAK1(5), PAK2(12), PRKDC(56), RB1(14), RIPK1(3), SPTAN1(22), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4)	22021439	240	117	234	71	63	28	41	36	69	3	0.284	1.000	1.000
311	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(8), ARHGAP4(4), ARHGAP5(26), ARHGAP6(12), ARHGEF1(12), ARHGEF11(25), ARHGEF5(7), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), BAIAP2(5), CFL1(1), DIAPH1(14), GSN(12), LIMK1(6), MYL2(9), MYLK(25), OPHN1(10), PFN1(1), PIP5K1A(3), PIP5K1B(2), PPP1R12B(16), ROCK1(20), SRC(5), TLN1(28), VCL(11)	26569801	277	116	264	70	89	38	32	45	67	6	0.0234	1.000	1.000
312	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(8), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BCL2L2(4), BOK(2), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP9(3), CD40(3), CD40LG(5), CRADD(6), DAXX(11), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), IKBKE(12), LTA(4), MCL1(2), NFKB1(8), NFKBIA(1), NGFR(7), NR3C1(9), NTRK1(9), PTPN13(34), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(4), TRAF2(4), TRAF3(7), TRAF6(6)	24737420	222	115	215	71	60	29	27	54	51	1	0.299	1.000	1.000
313	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(8), F11(5), F12(3), F13B(17), F2(11), F5(22), F7(11), F8(29), F9(9), FGA(12), FGB(6), FGG(5), LPA(21), PLAT(7), PLG(18), SERPINB2(9), SERPINE1(3), SERPINF2(8), VWF(38)	20687247	242	115	236	62	61	28	33	66	53	1	0.0449	1.000	1.000
314	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CFLAR(1), DAXX(11), DFFA(4), DFFB(3), FADD(3), FAF1(10), JUN(5), LMNA(11), LMNB1(4), LMNB2(6), MAP2K4(9), MAP3K1(16), MAP3K7(11), MAPK8(6), PAK1(5), PAK2(12), PRKDC(56), PTPN13(34), RB1(14), RIPK2(2), SPTAN1(22)	23128035	261	115	250	71	58	31	47	43	80	2	0.163	1.000	1.000
315	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(21), CALM1(2), CALM2(3), CALM3(1), CREB1(4), ELK1(4), FOS(1), GNAI1(3), GNAQ(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), JUN(5), MAPK3(3), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), RAF1(9), RPS6KA3(6), SYT1(5)	20074368	271	115	257	68	109	33	27	40	61	1	0.00224	1.000	1.000
316	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(3), ACAA2(9), ACADM(7), ACADS(4), ACAT1(6), ACAT2(5), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH7A1(2), ALDH9A1(6), AOX1(14), AUH(7), BCAT1(6), BCAT2(9), BCKDHA(12), BCKDHB(3), DBT(4), DLD(10), ECHS1(2), EHHADH(4), HADH(2), HADHA(5), HADHB(6), HIBADH(3), HIBCH(2), HMGCS1(2), HMGCS2(4), HSD17B4(7), IVD(4), MCCC1(4), MCCC2(7), MCEE(5), MUT(7), OXCT1(10), OXCT2(6), PCCA(12), PCCB(5)	25210128	263	115	242	67	60	41	33	42	86	1	0.0504	1.000	1.000
317	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(4), GTF2B(3), GTF2E1(6), GTF2E2(4), GTF2F1(6), GTF2F2(3), GTF2H1(5), GTF2H3(3), GTF2H4(9), GTF2I(4), GTF2IRD1(13), STON1(7), TAF1(27), TAF10(1), TAF13(1), TAF1L(37), TAF2(10), TAF4(14), TAF4B(7), TAF5(2), TAF5L(7), TAF6(14), TAF6L(7), TAF7(7), TAF7L(8), TAF9B(4), TBPL1(3), TBPL2(5)	21129651	224	115	214	56	55	31	28	47	63	0	0.0797	1.000	1.000
318	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	BCL2(4), CHUK(5), DAXX(11), EGF(11), EGFR(19), ETS1(8), ETS2(4), FOS(1), HOXA7(4), HRAS(1), IKBKB(10), JUN(5), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP3K5(10), MAPK1(3), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), NFKB1(8), NFKBIA(1), PPP2CA(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), RAF1(9), RELA(7), RIPK1(3), SP1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRAF2(4)	27922753	271	115	262	91	87	38	29	50	65	2	0.198	1.000	1.000
319	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	30	ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), AOX1(14), COMT(5), DBH(7), DCT(16), FAH(7), GOT1(3), GOT2(2), GSTZ1(2), HGD(6), HPD(4), MAOA(4), MAOB(3), TAT(5), TH(7), TPO(27), TYR(15)	17689406	209	115	193	60	56	16	25	52	58	2	0.228	1.000	1.000
320	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	AKR1C3(3), ALOX12(9), ALOX15(10), ALOX5(11), CBR1(1), CBR3(4), CYP4F2(13), CYP4F3(13), EPX(16), GGT1(9), LPO(11), LTA4H(4), MPO(9), PLA2G2A(2), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PRDX1(1), PRDX2(2), PRDX6(2), PTGDS(1), PTGES2(4), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7), TPO(27)	16123628	217	114	210	59	85	20	20	53	36	3	0.0295	1.000	1.000
321	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), ELK1(4), FPR1(8), GNA15(4), GNB1(2), GNGT1(3), HRAS(1), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), NCF1(3), NCF2(3), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKBIA(1), PAK1(5), PIK3C2G(14), PLCB1(21), PPP3CA(13), PPP3CB(6), PPP3CC(6), RAC1(1), RAF1(9), RELA(7), SYT1(5)	21937405	243	113	232	73	78	31	31	39	64	0	0.101	1.000	1.000
322	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	AGXT(3), AGXT2(13), ALAS1(5), ALAS2(14), AMT(4), AOC2(10), AOC3(13), ATP6V0C(1), BHMT(5), CBS(9), CHDH(6), CHKA(2), CHKB(3), CPT1B(7), CTH(3), DLD(10), DMGDH(7), GAMT(1), GARS(3), GATM(3), GCAT(5), GLDC(9), MAOA(4), MAOB(3), PEMT(1), PISD(5), PLCB2(8), PLCG1(22), PLCG2(19), PSPH(2), SARDH(12), SARS(9), SHMT1(2), SHMT2(11), TARS(11)	24124051	245	113	237	77	73	32	31	49	60	0	0.274	1.000	1.000
323	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(11), AKT1(3), AKT2(10), AKT3(8), DAG1(13), GNAQ(3), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(15), PIK3CB(13), PITX2(5), PLD1(22), PLD2(19), PLD3(8), VN1R1(4)	26265937	296	113	285	81	102	32	43	58	57	4	0.0289	1.000	1.000
324	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(5), BTK(4), CALM1(2), CALM2(3), CALM3(1), CD79A(8), CD79B(3), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP3K1(16), MAPK14(2), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SYK(9), SYT1(5), VAV1(13)	21983504	246	112	232	57	91	34	25	38	58	0	0.000846	1.000	1.000
325	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(4), AGTR2(4), CALM1(2), CALM2(3), CALM3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CDK5(3), F2(11), FYN(9), GNA11(6), GNAI1(3), GNB1(2), GNGT1(3), GRB2(4), HRAS(1), JAK2(12), MAP2K2(3), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), MAPT(11), MYLK(25), PLCG1(22), PRKCA(8), PTK2B(16), RAF1(9), SHC1(7), SOS1(9), STAT1(11), STAT3(7), STAT5A(10), SYT1(5)	23959637	247	111	241	73	83	36	26	52	48	2	0.0664	1.000	1.000
326	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(9), ALDOC(7), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GAPDHS(5), GCK(9), GOT1(3), GOT2(2), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHAL6B(6), LDHB(5), LDHC(1), MDH1(3), PC(18), PCK1(12), PDHA1(1), PDHA2(11), PDHB(4), PDHX(5), PFKL(8), PFKM(2), PFKP(21), PGAM1(1), PGAM2(5), PGK1(4), PGK2(3), PKLR(9), TNFAIP1(5), TPI1(3)	24880392	257	111	247	103	85	52	23	49	48	0	0.659	1.000	1.000
327	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(10), AADAC(6), ABAT(4), ACADS(4), ACAT1(6), ACAT2(5), ACSM1(7), AKR1B10(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH5A1(5), ALDH7A1(2), ALDH9A1(6), BDH1(7), DDHD1(13), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADH(2), HADHA(5), HMGCS1(2), HMGCS2(4), HSD17B4(7), HSD3B7(7), ILVBL(8), L2HGDH(2), OXCT1(10), OXCT2(6), PDHA1(1), PDHA2(11), PDHB(4), PLA1A(3), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(7)	23741398	245	111	228	83	72	33	29	43	68	0	0.425	1.000	1.000
328	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(8), CALCR(6), CALCRL(10), CD97(8), CRHR1(12), CRHR2(4), ELTD1(22), EMR1(11), EMR2(10), GHRHR(4), GIPR(6), GLP1R(1), GLP2R(10), GPR64(14), LPHN1(22), LPHN2(23), LPHN3(23), SCTR(5), VIPR1(3), VIPR2(5)	15573293	207	109	202	49	52	32	23	64	36	0	0.00274	1.000	1.000
329	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(20), CPS1(24), EARS2(3), EPRS(18), GAD1(8), GAD2(15), GCLC(3), GCLM(3), GFPT1(7), GFPT2(6), GLS(11), GLS2(8), GLUD1(4), GLUD2(13), GLUL(5), GMPS(7), GNPNAT1(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), GSR(5), GSS(2), NADSYN1(11), PPAT(7), QARS(7)	23154336	218	109	212	76	58	28	32	50	50	0	0.508	1.000	1.000
330	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(5), ALAS2(14), BLVRA(4), BLVRB(1), COX10(2), COX15(5), CP(10), CPOX(4), EARS2(3), EPRS(18), FECH(7), FTH1(3), FTMT(8), GUSB(10), HCCS(4), HMBS(3), HMOX1(7), HMOX2(1), MMAB(2), PPOX(6), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), UROD(2), UROS(5)	24626477	223	109	214	69	44	35	31	54	59	0	0.419	1.000	1.000
331	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(18), ADRBK2(5), ARRB2(2), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CLCA1(10), CLCA2(8), CLCA4(18), CNGA3(9), CNGA4(19), CNGB1(19), GNAL(3), GUCA1A(2), GUCA1B(1), GUCA1C(3), PDC(3), PDE1C(14), PRKACA(6), PRKACB(6), PRKACG(9), PRKG1(12), PRKG2(15), PRKX(6)	17888812	217	109	203	63	62	23	26	49	57	0	0.142	1.000	1.000
332	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3E(2), CD4(11), CREBBP(46), CSK(8), GNAS(38), GNB1(2), GNGT1(3), HLA-DRA(7), HLA-DRB1(1), LCK(4), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTPRC(21), ZAP70(13)	13504037	216	108	199	77	80	21	23	39	52	1	0.689	1.000	1.000
333	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3E(2), CD4(11), CREBBP(46), CSK(8), GNAS(38), GNB1(2), GNGT1(3), HLA-DRA(7), HLA-DRB1(1), LCK(4), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTPRC(21), ZAP70(13)	13504037	216	108	199	77	80	21	23	39	52	1	0.689	1.000	1.000
334	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	AGMAT(4), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH4A1(4), ALDH9A1(6), AMD1(7), AOC2(10), AOC3(13), ARG1(2), ARG2(3), ASL(5), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), GAMT(1), GATM(3), GLUD1(4), GOT1(3), GOT2(2), MAOA(4), MAOB(3), NOS1(39), NOS3(15), OAT(3), ODC1(3), OTC(4), P4HA1(5), P4HA2(8), P4HA3(6), P4HB(3), PYCR1(3), RARS(5), SMS(6)	25424703	277	107	258	81	79	29	42	56	71	0	0.234	1.000	1.000
335	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(5), EGF(11), EGFR(19), ELK1(4), FOS(1), GRB2(4), HRAS(1), JAK1(19), JUN(5), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5), STAT1(11), STAT3(7), STAT5A(10)	20262096	222	107	209	53	58	29	21	37	72	5	0.0299	1.000	1.000
336	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	39	ALG1(8), ALG10B(10), ALG11(8), ALG12(10), ALG13(8), ALG14(2), ALG2(3), ALG3(4), ALG5(4), ALG6(4), ALG8(3), ALG9(2), B4GALT1(3), B4GALT2(8), B4GALT3(2), DHDDS(2), DPAGT1(6), DPM1(2), FUT8(9), GANAB(19), MAN1A1(4), MAN1A2(5), MAN1B1(6), MAN1C1(10), MAN2A1(10), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), MGAT5B(7), RFT1(4), RPN1(4), RPN2(6), ST6GAL1(1), STT3B(5)	23916178	216	107	201	69	47	29	20	47	71	2	0.688	1.000	1.000
337	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(49), ATR(28), BRCA1(16), BRCA2(39), CHEK1(6), CHEK2(10), FANCA(12), FANCC(6), FANCD2(14), FANCE(6), FANCF(1), FANCG(4), HUS1(2), MRE11A(7), RAD1(2), RAD17(6), RAD50(12), RAD51(1), RAD9A(5), TREX1(4)	25422455	230	106	216	41	39	29	29	41	84	8	0.0158	1.000	1.000
338	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACAA2(9), ACADL(3), ACADM(7), ACADS(4), ACADSB(8), ACADVL(3), ACAT1(6), ACAT2(5), ACOX1(3), ACOX3(13), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), CYP4A11(4), CYP4A22(5), ECHS1(2), EHHADH(4), GCDH(7), HADH(2), HADHA(5), HADHB(6), HSD17B4(7)	28695790	263	106	245	61	61	41	39	43	79	0	0.00310	1.000	1.000
339	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(28), ACAT1(6), ACAT2(5), ACYP1(1), ACYP2(3), ADH5(4), AKR1B1(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), DLAT(8), DLD(10), GLO1(2), GRHPR(2), HAGH(5), HAGHL(2), LDHA(7), LDHB(5), LDHC(1), LDHD(2), MDH1(3), ME1(1), ME2(7), ME3(7), PC(18), PCK1(12), PDHA1(1), PDHA2(11), PDHB(4), PKLR(9)	21636561	237	106	221	84	63	36	31	42	65	0	0.716	1.000	1.000
340	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(8), CDC7(7), CDK2(4), CDT1(5), DIAPH2(10), GMNN(2), MCM10(13), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), NACA(19), PCNA(2), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), PRIM1(2), RFC1(14), RFC2(3), RFC3(4), RFC4(1), RFC5(2), RPA1(3), RPA2(4), RPA3(1), RPA4(6), RPS27A(4), UBA52(2), UBB(2), UBC(9)	29739675	257	105	247	64	83	30	28	42	74	0	0.0488	1.000	1.000
341	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(10), ATM(49), ATR(28), CCNA1(10), CCND1(2), CCNE1(5), CDC25A(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2B(1), E2F1(4), GSK3B(6), HDAC1(9), RB1(14), SKP2(6), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9)	16911835	191	105	182	56	38	25	26	36	63	3	0.487	1.000	1.000
342	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(8), AASDH(10), AASDHPPT(1), AASS(10), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), ATP6V0C(1), BBOX1(4), DLST(6), DOT1L(18), ECHS1(2), EHHADH(4), EHMT1(18), EHMT2(19), GCDH(7), HADHA(5), PLOD1(9), PLOD2(15), PLOD3(17), SDS(4), SHMT1(2), SHMT2(11), TMLHE(5)	21645601	254	105	230	70	65	32	37	39	80	1	0.0650	1.000	1.000
343	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), DAG1(13), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), NFAT5(13), PDE6A(9), PDE6B(14), PDE6C(5), PDE6D(1), PDE6G(1), PDE6H(1), SLC6A13(8), TF(15)	20936097	229	105	222	82	84	27	33	41	41	3	0.296	1.000	1.000
344	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(19), ELK1(4), GNAS(38), GNB1(2), GNGT1(3), GRB2(4), HRAS(1), IGF1R(20), ITGB1(11), KLK2(1), MAP2K2(3), MAPK1(3), MAPK3(3), MKNK1(5), MKNK2(8), MYC(6), NGFR(7), PDGFRA(13), PPP2CA(4), PTPRR(10), RAF1(9), RPS6KA1(9), RPS6KA5(5), SHC1(7), SOS1(9), SRC(5), STAT3(7)	18970030	216	104	204	85	84	27	20	51	33	1	0.771	1.000	1.000
345	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(28), ACACB(40), ACADM(7), ACAT1(6), ACAT2(5), ACSS1(16), ACSS2(12), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH7A1(2), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), HIBCH(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), MCEE(5), MLYCD(8), MUT(7), PCCA(12), PCCB(5), SUCLA2(3), SUCLG1(2), SUCLG2(8)	23267028	264	104	243	56	64	42	31	52	74	1	0.00275	1.000	1.000
346	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(8), ARSB(2), FUCA1(1), FUCA2(2), GALNS(3), GBA(12), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), HGSNAT(5), HPSE(11), HPSE2(10), HYAL1(7), HYAL2(8), IDS(4), IDUA(4), LCT(24), MAN2B1(19), MAN2B2(19), MAN2C1(11), MANBA(10), NAGLU(8), NEU1(3), NEU2(7), NEU3(5), NEU4(3), SPAM1(10)	20139847	226	104	221	58	69	37	38	33	49	0	0.0125	1.000	1.000
347	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	31	ACTA1(4), CRK(1), CRKL(2), DOCK1(20), ELK1(4), FOS(1), GAB1(4), GRB2(4), HRAS(1), ITGA1(7), ITGB1(11), JUN(5), MAP2K2(3), MAP4K1(4), MAPK1(3), MAPK3(3), MAPK8(6), MET(10), PAK1(5), PIK3R1(12), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAF1(9), RAP1A(3), RAP1B(6), RASA1(19), SOS1(9), SRC(5), STAT3(7)	22795088	209	104	198	65	55	18	29	46	59	2	0.365	1.000	1.000
348	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JAK1(19), JUN(5), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), PDGFA(2), PDGFRA(13), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5), STAT1(11), STAT3(7), STAT5A(10)	18754006	207	104	195	45	50	27	22	34	69	5	0.0105	1.000	1.000
349	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(10), AKT3(8), CISH(4), GRB2(4), IARS(11), IL13RA1(5), IL2RG(9), IL4(4), IL4R(7), INPP5D(8), JAK1(19), JAK2(12), JAK3(12), NR0B2(3), PI3(2), PPP1R13B(15), RPS6KB1(6), SERPINA4(5), SHC1(7), SOS1(9), SOS2(18), SRC(5), STAT6(7), TYK2(12)	20319757	205	103	189	51	47	29	22	38	66	3	0.203	1.000	1.000
350	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(8), EIF1(1), EIF2B1(4), EIF2B2(4), EIF2B3(9), EIF2B4(11), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), ELAVL1(9), FLT1(19), FLT4(31), HIF1A(5), HRAS(1), KDR(17), NOS3(15), PIK3R1(12), PLCG1(22), PRKCA(8), PTK2(11), PXN(6), SHC1(7), VHL(2)	18625660	217	103	205	53	64	23	33	43	53	1	0.0193	1.000	1.000
351	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(26), DIAPH1(14), FYN(9), GSN(12), HRAS(1), ITGA1(7), ITGB1(11), MAPK1(3), MAPK3(3), MYL2(9), MYLK(25), PFN1(1), PIK3R1(12), PTK2(11), PXN(6), RAF1(9), ROCK1(20), SHC1(7), SRC(5), TLN1(28)	20168269	219	102	207	45	65	27	26	40	54	7	0.00252	1.000	1.000
352	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(3), ALOX12(9), ALOX12B(12), ALOX15(10), ALOX15B(4), ALOX5(11), CBR1(1), CBR3(4), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2J2(4), CYP2U1(9), CYP4A11(4), CYP4A22(5), CYP4F2(13), CYP4F3(13), DHRS4(4), EPHX2(3), GGT1(9), GPX5(2), GPX7(3), LTA4H(4), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PTGDS(1), PTGES(1), PTGES2(4), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7)	22588028	235	102	231	66	88	25	25	52	43	2	0.0336	1.000	1.000
353	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(4), CDK5(3), CDK5R1(5), CFL1(1), CHN1(4), LIMK1(6), MAP3K1(16), MYL2(9), MYLK(25), NCF2(3), PAK1(5), PDGFRA(13), PIK3R1(12), PLD1(22), PPP1R12B(16), RAC1(1), RALBP1(10), RPS6KB1(6), TRIO(47), VAV1(13), WASF1(8)	19193646	229	102	220	66	63	31	23	52	57	3	0.231	1.000	1.000
354	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(53), ASAH1(4), CAMP(3), CASP3(2), CERK(7), CREB1(4), CREB5(7), CXCL2(2), DAG1(13), EPHB2(15), FOS(1), GNAQ(3), ITPKA(2), ITPKB(14), JUN(5), MAP2K4(9), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5)	16321854	186	102	178	53	49	21	23	31	57	5	0.123	1.000	1.000
355	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(3), CALM3(1), CHUK(5), EGR2(9), EGR3(9), GNAQ(3), MAP3K1(16), MYC(6), NFATC1(16), NFATC2(26), NFKB1(8), NFKBIA(1), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RELA(7), SYT1(5), VIP(7), VIPR2(5)	16402640	215	102	202	57	75	28	17	38	57	0	0.0189	1.000	1.000
356	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(3), B4GALT2(8), FBP2(6), GAA(8), GALE(1), GALK1(4), GALK2(3), GALT(3), GANAB(19), GCK(9), GLA(3), GLB1(7), HK1(17), HK2(12), HK3(11), LALBA(1), LCT(24), MGAM(19), PFKM(2), PFKP(21), PGM1(3), PGM3(13)	19015189	203	101	185	77	73	26	21	42	41	0	0.694	1.000	1.000
357	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), AVP(4), CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), HDAC5(13), IGF1(2), IGF1R(20), INSR(17), MAP2K6(1), MAPK14(2), MAPK7(8), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MYOD1(7), NFATC1(16), NFATC2(26), PIK3R1(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), SYT1(5), YWHAH(3)	19064440	222	101	214	83	74	27	33	35	51	2	0.400	1.000	1.000
358	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), FPGT(7), FUK(7), GMDS(1), GMPPA(7), GMPPB(6), HK1(17), HK2(12), HK3(11), HSD3B7(7), KHK(2), LHPP(3), MPI(3), MTMR1(7), MTMR2(9), MTMR6(9), PFKFB1(6), PFKFB2(5), PFKFB3(8), PFKFB4(5), PFKL(8), PFKM(2), PFKP(21), PGM2(1), PHPT1(2), PMM1(3), PMM2(2), RDH11(1), RDH12(3), RDH13(7), SORD(3), TPI1(3), TSTA3(9)	21716824	236	101	229	75	85	39	30	29	53	0	0.0704	1.000	1.000
359	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(6), B4GALT1(3), B4GALT2(8), G6PC2(1), GAA(8), GALE(1), GALK1(4), GALK2(3), GALT(3), GANC(9), GCK(9), GLA(3), GLB1(7), HK1(17), HK2(12), HK3(11), HSD3B7(7), LALBA(1), LCT(24), MGAM(19), PFKL(8), PFKM(2), PFKP(21), PGM1(3), PGM3(13), RDH11(1), RDH12(3), RDH13(7), UGP2(9)	22544622	229	101	215	91	87	29	26	42	45	0	0.810	1.000	1.000
360	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(14), ATP4B(4), ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), ATP7A(16), ATP7B(15), COX10(2), COX4I1(4), COX5B(1), COX6B1(2), COX7A1(1), COX7B(3), COX7C(1), COX8A(1), NDUFA1(1), NDUFA10(3), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(6), NDUFV1(6), NDUFV2(1), PPA2(3), SDHA(11), SDHB(4), SHMT1(2), UQCRB(2), UQCRC1(3), UQCRFS1(3)	21762650	221	101	217	67	67	31	35	39	48	1	0.161	1.000	1.000
361	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(16), DYRK1B(15), GLI2(18), GLI3(60), GSK3B(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), SHH(6), SMO(15), SUFU(6)	9753396	181	101	173	70	66	24	13	39	37	2	0.450	1.000	1.000
362	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(4), AGTR1(1), ATF2(4), CALM1(2), CALM2(3), CALM3(1), EGFR(19), ELK1(4), GNAQ(3), GRB2(4), HRAS(1), JUN(5), MAP2K2(3), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), PAK1(5), PRKCA(8), PTK2(11), PTK2B(16), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SRC(5), SYT1(5)	19186436	188	100	179	55	56	18	23	31	59	1	0.166	1.000	1.000
363	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(20), CPS1(24), EPRS(18), GAD1(8), GAD2(15), GCLC(3), GCLM(3), GFPT1(7), GLS(11), GLS2(8), GLUD1(4), GLUL(5), GMPS(7), GOT1(3), GOT2(2), GPT(4), GPT2(3), GSS(2), NADSYN1(11), PPAT(7), QARS(7)	19463962	185	100	181	61	48	26	28	39	44	0	0.408	1.000	1.000
364	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(7), CAPN2(10), CAPNS1(3), CAPNS2(2), CXCR3(2), EGF(11), EGFR(19), HRAS(1), ITGA1(7), ITGB1(11), MAPK1(3), MAPK3(3), MYL2(9), MYLK(25), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTK2(11), PXN(6), TLN1(28)	19153213	201	100	192	67	73	30	18	34	45	1	0.227	1.000	1.000
365	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(4), CDC42(3), CREB1(4), DAXX(11), DDIT3(5), ELK1(4), GRB2(4), HMGN1(2), HRAS(1), HSPB1(2), HSPB2(1), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP3K5(10), MAP3K7(11), MAP3K9(5), MAPK14(2), MAPKAPK2(3), MAPKAPK5(4), MAX(3), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MKNK1(5), MYC(6), PLA2G4A(7), RAC1(1), RIPK1(3), RPS6KA5(5), SHC1(7), STAT1(11), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TRADD(2), TRAF2(4)	21478710	206	100	198	54	53	30	26	33	61	3	0.0560	1.000	1.000
366	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(9), AZIN1(4), CLDN5(4), CLOCK(8), CRY1(3), CRY2(7), DAZAP2(4), DNAJA1(9), ETV6(9), G0S2(3), GFRA1(10), GSTM3(2), GSTP1(1), HERPUD1(2), HSPA8(5), IDI1(2), KLF9(3), MYF6(4), NCKAP1(13), NCOA4(7), NR1D2(8), PER1(6), PER2(15), PPP1R3C(4), PPP2CB(4), PSMA4(4), PURA(2), SF3A3(2), SUMO3(7), TOB1(1), TUBB3(10), UCP3(4), UGP2(9), VAPA(3), ZFR(16)	21203060	204	99	196	63	57	18	28	41	59	1	0.484	1.000	1.000
367	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(21), AKT1(3), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CREB1(4), GNAS(38), GRB2(4), HRAS(1), MAPK1(3), MAPK14(2), MAPK3(3), PIK3R1(12), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), RAC1(1), RPS6KA1(9), RPS6KA5(5), SOS1(9)	15815023	184	98	176	55	65	23	19	31	43	3	0.261	1.000	1.000
368	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	33	ALDH4A1(4), ARG1(2), ARG2(3), ASL(5), ASS1(10), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), EPRS(18), GAMT(1), GATM(3), GLUD1(4), GLUD2(13), GOT1(3), GOT2(2), LAP3(4), NOS1(39), NOS3(15), OAT(3), OTC(4), P4HA1(5), P4HA2(8), P4HA3(6), PRODH(1), PYCR1(3), PYCR2(4), PYCRL(2), RARS(5), RARS2(6)	20571702	215	98	205	71	65	26	32	48	44	0	0.458	1.000	1.000
369	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ACY3(3), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH7A1(2), ALDH9A1(6), AMDHD1(1), AOC2(10), AOC3(13), ASPA(2), CARM1(8), CNDP1(5), FTCD(7), HAL(4), HARS(9), HARS2(4), HDC(11), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(11), MAOA(4), MAOB(3), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), PRPS1(3), PRPS2(3), UROC1(12), WBSCR22(5)	22583492	235	98	219	56	55	25	34	46	74	1	0.0339	1.000	1.000
370	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(8), POLA2(4), POLB(6), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLG(10), POLG2(5), POLH(7), POLI(3), POLK(10), POLL(4), POLM(13), POLQ(37), PRIM1(2), PRIM2(7), REV1(9), REV3L(50), RFC5(2)	23776885	246	98	236	68	60	37	29	37	79	4	0.335	1.000	1.000
371	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(3), CALM3(1), DLG4(4), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), NOS1(39), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), SYT1(5)	14963506	203	98	194	65	70	26	22	39	46	0	0.131	1.000	1.000
372	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(21), ARHGEF1(12), F2(11), F2R(6), F2RL3(4), GNA12(1), GNA13(7), GNAI1(3), GNAQ(3), GNB1(2), GNGT1(3), MAP3K7(11), PIK3R1(12), PLCB1(21), PPP1R12B(16), PRKCA(8), PTK2B(16), ROCK1(20)	13867655	177	98	172	44	52	21	24	33	43	4	0.0324	1.000	1.000
373	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(8), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CASP2(3), CASP3(2), CASP6(1), CASP7(4), CASP9(3), FADD(3), FAS(3), FASLG(5), GZMB(2), JUN(5), MAP2K4(9), MAP3K1(16), MAPK10(4), MCL1(2), MDM2(8), MYC(6), NFKB1(8), NFKBIA(1), PARP1(13), PRF1(13), RELA(7), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(9), TRADD(2), TRAF1(4), TRAF2(4)	20735875	189	97	178	54	48	27	18	37	56	3	0.182	1.000	1.000
374	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), EPX(16), ESCO1(10), ESCO2(10), GOT1(3), GOT2(2), HPD(4), LPO(11), MAOA(4), MAOB(3), MIF(1), MPO(9), NAT6(4), PNPLA3(4), PRDX6(2), SH3GLB1(3), TAT(5), TPO(27)	19451568	175	97	164	42	49	15	15	43	52	1	0.150	1.000	1.000
375	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(21), CAP1(2), CCNB1(3), CDC25C(11), GNAI1(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), MAPK1(3), MAPK3(3), MYT1(22), PIN1(2), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RPS6KA1(9), SRC(5)	12084317	171	97	162	54	64	22	12	36	35	2	0.304	1.000	1.000
376	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(4), BCR(14), BLNK(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8IP3(12), PAPPA(29), RAC1(1), RPS6KA1(9), RPS6KA3(6), SHC1(7), SOS1(9), SYK(9), VAV1(13), VAV2(13), VAV3(14)	18301724	189	97	183	66	58	26	22	40	43	0	0.412	1.000	1.000
377	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	BAD(4), BRAF(18), CREB1(4), CREB5(7), DUSP4(2), DUSP6(4), DUSP9(8), EEF2K(11), EIF4E(2), GRB2(4), MAP2K2(3), MAP3K8(2), MAPK1(3), MAPK3(3), MKNK1(5), MKNK2(8), MOS(11), NFKB1(8), RAP1A(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), SHC1(7), SOS1(9), SOS2(18), TRAF3(7)	16834462	178	97	167	63	50	26	13	38	51	0	0.737	1.000	1.000
378	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ACADL(3), ACADM(7), ACADSB(8), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), AOC2(10), AOC3(13), CNDP1(5), DPYD(20), DPYS(8), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), MLYCD(8), SDS(4), SMS(6), UPB1(6)	17035869	203	96	189	49	44	25	28	44	62	0	0.0219	1.000	1.000
379	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(22), EXT2(7), EXTL1(8), EXTL2(2), EXTL3(12), GLCE(6), HS2ST1(3), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), HS3ST5(8), HS6ST1(7), HS6ST2(9), HS6ST3(9), NDST1(13), NDST2(13), NDST3(18), NDST4(17)	12130671	180	96	170	61	59	27	19	49	25	1	0.488	1.000	1.000
380	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2(4), GRB2(4), GSK3A(4), GSK3B(6), IL4R(7), IRS1(27), IRS2(10), JAK1(19), JAK3(12), MAP4K1(4), MAPK1(3), MAPK3(3), PDK1(3), PIK3CD(15), PIK3R1(12), PPP1R13B(15), RAF1(9), SHC1(7), SOCS1(1), SOS1(9), SOS2(18), STAT6(7)	20138806	224	96	205	58	66	30	21	33	70	4	0.133	1.000	1.000
381	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(4), DLG4(4), EPHB2(15), F2(11), F2RL1(1), F2RL2(4), F2RL3(4), JUN(5), MAP2K5(1), MAPK1(3), MAPK7(8), MAPK8(6), MYEF2(8), PLD1(22), PLD2(19), PLD3(8), PTK2(11), RAF1(9), RASAL1(11), SRC(5), TEC(4), VAV1(13)	16061421	176	96	174	48	58	24	19	32	43	0	0.0884	1.000	1.000
382	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACAA2(9), ACADL(3), ACADM(7), ACADS(4), ACADSB(8), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH9A1(6), AOX1(14), BCAT1(6), BCKDHA(12), BCKDHB(3), ECHS1(2), EHHADH(4), HADHA(5), HADHB(6), HIBADH(3), IVD(4), MCCC1(4), MCCC2(7), MCEE(5), MUT(7), OXCT1(10), PCCA(12), PCCB(5), SDS(4)	21103575	231	96	212	60	45	39	32	38	76	1	0.0999	1.000	1.000
383	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(7), ACTN2(26), BCAR1(10), CSK(8), CTNNA1(17), CTNNA2(24), CTNNB1(27), PTK2(11), PXN(6), SRC(5), VCL(11)	11204907	152	95	142	53	54	10	20	36	29	3	0.592	1.000	1.000
384	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(9), ACP2(5), ACP5(3), ACPP(5), ACPT(6), ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), CYP19A1(12), CYP1A1(7), CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2D6(13), CYP2E1(6), CYP2F1(9), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(4), CYP4B1(11), CYP51A1(9), PON1(3)	17197789	199	95	189	65	80	22	19	34	44	0	0.246	1.000	1.000
385	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(4), ARSD(5), ARSE(6), ASAH1(4), B4GALT6(6), CERK(7), DEGS1(1), DEGS2(2), ENPP7(4), GAL3ST1(12), GALC(5), GBA(12), GLA(3), GLB1(7), LCT(24), NEU1(3), NEU2(7), NEU3(5), NEU4(3), PPAP2A(3), PPAP2B(2), PPAP2C(6), SGMS1(4), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(6), SMPD2(3), SMPD3(10), SMPD4(12), SPHK1(10), SPHK2(8), SPTLC1(5), SPTLC2(4), UGCG(3), UGT8(6)	20903003	211	95	204	74	70	29	31	37	44	0	0.407	1.000	1.000
386	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(10), CALM1(2), CALM2(3), CALM3(1), CRKL(2), GNAQ(3), GRB2(4), HRAS(1), JUN(5), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), PAK1(5), PLCG1(22), PRKCA(8), PTK2B(16), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SRC(5), SYT1(5)	16238439	171	95	163	42	61	17	19	26	47	1	0.0255	1.000	1.000
387	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	29	A1BG(3), AKT1(3), AKT2(10), AKT3(8), BAD(4), BTK(4), DAPP1(1), GRB2(4), GSK3A(4), GSK3B(6), IARS(11), INPP5D(8), PDK1(3), PPP1R13B(15), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SOS1(9), SOS2(18), TEC(4), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3)	18801703	174	95	168	58	47	26	20	35	46	0	0.614	1.000	1.000
388	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(7), ACTN2(26), CAPN1(7), CAPNS1(3), CAPNS2(2), ITGA1(7), ITGB1(11), ITGB3(6), PTK2(11), PXN(6), RAC1(1), SPTAN1(22), SRC(5), TLN1(28)	16715768	146	95	140	53	69	15	13	27	22	0	0.453	1.000	1.000
389	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(5), CSNK1D(4), DRD1(4), DRD2(10), GRM1(43), PLCB1(21), PPP1CA(2), PPP1R1B(3), PPP2CA(4), PPP3CA(13), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	9390687	151	94	145	39	44	20	18	34	35	0	0.0343	1.000	1.000
390	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(8), GTF2A1(3), GTF2B(3), GTF2E1(6), GTF2F1(6), HDAC3(7), NCOA1(20), NCOA2(27), NCOA3(15), NCOR2(40), POLR2A(24), RARA(4), RXRA(13), TBP(6)	14567533	182	94	179	66	57	35	23	31	33	3	0.519	1.000	1.000
391	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(2), GHR(9), GRB2(4), HRAS(1), INSR(17), IRS1(27), JAK2(12), MAPK1(3), MAPK3(3), PIK3R1(12), PLCG1(22), PRKCA(8), PTPN6(6), RAF1(9), RPS6KA1(9), SHC1(7), SLC2A4(5), SOCS1(1), SOS1(9), SRF(5), STAT5A(10), STAT5B(13)	17666154	194	93	187	53	55	33	23	27	52	4	0.0655	1.000	1.000
392	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAA2(9), ACAD8(5), ACAD9(8), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1B10(6), AKR1C4(5), AKR1D1(4), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), BAAT(6), CEL(16), CYP27A1(6), CYP7A1(7), HADHB(6), HSD3B7(7), LIPA(3), RDH11(1), RDH12(3), RDH13(7), SLC27A5(5), SOAT1(11), SOAT2(3), SRD5A1(2)	18514509	209	93	194	53	48	32	39	36	54	0	0.0310	1.000	1.000
393	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ACADM(7), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AOC2(10), AOC3(13), CNDP1(5), DPYD(20), DPYS(8), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), HIBCH(2), MLYCD(8), SMS(6), SRM(1), UPB1(6)	15819734	181	93	167	40	40	21	24	38	58	0	0.0105	1.000	1.000
394	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(4), CHIT1(5), CMAS(6), CTBS(3), CYB5R1(3), CYB5R3(4), GFPT1(7), GFPT2(6), GNE(11), GNPDA1(4), GNPDA2(7), GNPNAT1(6), HEXA(2), HEXB(3), HK1(17), HK2(12), HK3(11), LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), NANS(6), NPL(4), PGM3(13), PHPT1(2), RENBP(3), UAP1(5)	16801825	177	93	170	47	47	29	24	41	36	0	0.0260	1.000	1.000
395	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), ERCC3(8), GTF2B(3), GTF2E1(6), GTF2E2(4), GTF2F2(3), GTF2H1(5), GTF2H4(9), ILK(9), MNAT1(3), POLR1A(19), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3B(11), POLR3D(5), POLR3E(6), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(14), TAF7(7), TBP(6)	20533691	185	92	182	64	57	19	27	31	51	0	0.629	1.000	1.000
396	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), P4HB(3), SLC23A1(7), SLC23A2(10), SLC2A1(8), SLC2A3(10)	14684253	153	92	147	54	45	28	17	29	32	2	0.278	1.000	1.000
397	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(17), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC4(2), ANAPC5(5), ANAPC7(6), BTRC(9), CDC16(7), CDC20(7), CDC23(6), CDC26(2), CDC27(5), CUL1(24), CUL2(9), CUL3(8), FBXW11(9), FZR1(8), ITCH(4), RBX1(1), SKP2(6), SMURF1(7), SMURF2(5), TCEB1(1), UBA1(4), UBE2C(1), UBE2D3(1), UBE2E1(2), UBE2E2(1), UBE2E3(3), VHL(2), WWP1(13), WWP2(15)	22554141	200	91	189	42	57	26	28	32	56	1	0.00312	1.000	1.000
398	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), BAD(4), BCL2(4), BCL2L1(1), CBL(5), CFLAR(1), CRKL(2), E2F1(4), FOS(1), GRB2(4), HRAS(1), IL2RA(2), IL2RB(3), IL2RG(9), IRS1(27), JAK1(19), JAK3(12), MAPK1(3), MAPK3(3), MYC(6), NMI(2), PIK3R1(12), PTPN6(6), RAF1(9), RPS6KB1(6), SHC1(7), SOCS1(1), SOCS3(3), SOS1(9), STAT5A(10), STAT5B(13), SYK(9)	19871913	201	91	188	57	46	30	25	34	62	4	0.320	1.000	1.000
399	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(17), BAIAP2(5), CASP1(3), CASP3(2), CASP7(4), GAPDH(3), INSR(17), ITCH(4), MAGI1(26), MAGI2(28), RERE(30), WWP1(13), WWP2(15)	13381859	167	90	161	48	42	22	21	30	50	2	0.267	1.000	1.000
400	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(4), CREBBP(46), EP300(27), FYN(9), IL2RG(9), IL7(2), IL7R(15), JAK1(19), JAK3(12), LCK(4), NMI(2), PIK3R1(12), PTK2B(16), STAT5A(10), STAT5B(13)	15082976	200	90	183	42	50	24	25	37	61	3	0.0139	1.000	1.000
401	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), CDC42(3), CREB1(4), CREB5(7), DUSP1(3), DUSP10(8), EEF2K(11), EIF4E(2), ELK1(4), HSPB1(2), IL1R1(4), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K10(13), MAP3K4(26), MAP3K5(10), MAP3K7(11), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPKAPK2(3), MAPKAPK5(4), MKNK1(5), MKNK2(8), MYEF2(8), NFKB1(8), NR2C2(6), SRF(5), TRAF6(6)	19513196	196	90	191	54	45	40	25	35	50	1	0.0311	1.000	1.000
402	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(11), AGT(4), AGTR1(1), AGTR2(4), CMA1(2), COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), REN(7)	14801470	144	89	141	48	35	30	16	29	32	2	0.314	1.000	1.000
403	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(10), ATM(49), BRCA1(16), CDKN1A(5), CHEK1(6), CHEK2(10), JUN(5), MAPK8(6), MDM2(8), MRE11A(7), NFKB1(8), NFKBIA(1), RAD50(12), RAD51(1), RBBP8(5), RELA(7), TP73(6)	17007581	162	89	150	36	29	20	20	30	59	4	0.140	1.000	1.000
404	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(5), B4GALT5(4), C1GALT1(3), C1GALT1C1(6), GALNT1(4), GALNT10(8), GALNT11(6), GALNT12(3), GALNT13(9), GALNT14(12), GALNT2(7), GALNT3(4), GALNT4(6), GALNT5(12), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GALNTL5(3), GCNT1(1), GCNT3(4), GCNT4(4), OGT(7), ST3GAL1(5), ST3GAL2(9), ST6GALNAC1(5), WBSCR17(27)	18955878	173	89	169	66	60	21	21	33	37	1	0.902	1.000	1.000
405	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(3), GORASP1(4), MAP2K4(9), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MAPKAPK5(4), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PIK3CD(15), PIK3R1(12), SYT1(5), TRAF2(4), TRAF3(7), TRAF5(4), TRAF6(6)	17974991	158	89	154	42	51	21	15	27	40	4	0.0673	1.000	1.000
406	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(5), EGF(11), EGFR(19), GRB2(4), HRAS(1), MAPK1(3), MAPK3(3), PTPRB(26), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SPRY1(2), SPRY3(8), SPRY4(6), SRC(5)	14188104	137	89	133	43	36	19	12	36	33	1	0.528	1.000	1.000
407	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(5), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAPK3(3), MPL(5), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), STAT1(11), STAT3(7), STAT5A(10), STAT5B(13), THPO(6)	15860375	169	89	163	33	45	21	19	33	48	3	0.00578	1.000	1.000
408	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(11), ACO1(7), ACO2(11), CLYBL(3), CS(1), DLD(10), DLST(6), FH(4), IDH1(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), OGDH(11), OGDHL(19), PC(18), PCK1(12), PCK2(10), SDHA(11), SDHB(4), SDHC(2), SDHD(1), SUCLA2(3), SUCLG1(2), SUCLG2(8)	17518974	173	88	164	57	59	26	19	24	45	0	0.372	1.000	1.000
409	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAPN2(10), CAPNS1(3), CAPNS2(2), EP300(27), HDAC1(9), HDAC2(6), MEF2D(8), NFATC1(16), NFATC2(26), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), SYT1(5)	14300668	171	88	161	44	61	20	21	28	41	0	0.0121	1.000	1.000
410	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(28), ACADL(3), ACADM(7), ACADSB(8), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), LDHA(7), LDHB(5), LDHC(1), MCEE(5), MLYCD(8), MUT(7), PCCA(12), PCCB(5), SDS(4), SUCLA2(3), SUCLG1(2), SUCLG2(8)	19421267	212	88	194	50	48	35	28	40	61	0	0.0392	1.000	1.000
411	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(41), MAP2(40), PPP1CA(2), PPP2CA(4), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAR2A(3), PRKAR2B(9), PRKCE(14)	10666615	133	87	126	44	23	13	22	43	30	2	0.756	1.000	1.000
412	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(10), ABAT(4), ACADS(4), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH5A1(5), ALDH9A1(6), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), L2HGDH(2), OXCT1(10), PDHA1(1), PDHA2(11), PDHB(4), SDHB(4), SDS(4)	15106691	171	87	159	62	42	22	21	33	53	0	0.684	1.000	1.000
413	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(3), BCL2(4), BCR(14), CRKL(2), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), MYC(6), PIK3R1(12), RAF1(9), SOS1(9), STAT1(11), STAT5A(10), STAT5B(13)	14732104	150	87	143	37	35	20	16	25	51	3	0.0524	1.000	1.000
414	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(5), IFNA1(1), IFNB1(3), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1RAP(6), IL1RN(1), IRAK1(7), IRAK2(11), IRAK3(9), JUN(5), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAP3K7(11), MAPK14(2), MAPK8(6), MYD88(4), NFKB1(8), NFKBIA(1), RELA(7), TGFB1(3), TGFB2(9), TGFB3(9), TNF(3), TOLLIP(6), TRAF6(6)	17372497	171	87	164	44	39	26	16	34	55	1	0.0997	1.000	1.000
415	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(34), C5(13), C6(13), C7(7), ICAM1(4), IL1A(2), ITGA4(16), ITGAL(22), ITGB1(11), ITGB2(12), SELP(11), SELPLG(9), TNF(3), VCAM1(9)	14536352	166	87	156	45	50	17	20	44	35	0	0.0354	1.000	1.000
416	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), CHUK(5), ELK1(4), FOS(1), IKBKB(10), IRAK1(7), JUN(5), LY96(5), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP3K7(11), MAPK14(2), MAPK8(6), MYD88(4), NFKB1(8), NFKBIA(1), PPARA(7), RELA(7), TIRAP(1), TLR10(9), TLR2(4), TLR3(6), TLR6(4), TLR7(6), TLR9(15), TOLLIP(6), TRAF6(6)	20364152	178	87	173	52	48	27	19	28	55	1	0.0974	1.000	1.000
417	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(8), BCL2(4), BID(2), BIRC2(7), BIRC3(10), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CASP9(3), CFLAR(1), CHUK(5), DFFA(4), DFFB(3), FADD(3), GAS2(2), LMNA(11), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), SPTAN1(22), TNFRSF10A(2), TNFRSF10B(2), TNFRSF25(5), TNFSF10(9), TRADD(2), TRAF2(4)	18884207	143	86	138	40	36	26	9	35	36	1	0.270	1.000	1.000
418	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(6), ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), FPGT(7), GCK(9), GMDS(1), GMPPA(7), GMPPB(6), HK1(17), HK2(12), HK3(11), KHK(2), MPI(3), PFKFB1(6), PFKFB3(8), PFKFB4(5), PFKM(2), PFKP(21), PMM1(3), PMM2(2), SORD(3), TPI1(3)	13995465	161	86	156	51	64	25	18	22	32	0	0.0962	1.000	1.000
419	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(11), CS(1), DLAT(8), DLD(10), DLST(6), FH(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), OGDH(11), PC(18), PDHA1(1), PDHA2(11), PDHB(4), PDHX(5), PDK1(3), PDK2(1), PDK3(6), PDK4(5), PDP2(5), SDHA(11), SDHB(4), SDHC(2), SDHD(1), SUCLA2(3), SUCLG1(2), SUCLG2(8)	16636416	156	86	147	58	43	26	19	28	40	0	0.754	1.000	1.000
420	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(46), DAXX(11), HRAS(1), PAX3(14), PML(16), RARA(4), RB1(14), SIRT1(8), SP100(19), TNF(3), TNFRSF1A(6), TNFRSF1B(3)	10673414	145	86	140	38	48	18	23	20	36	0	0.0517	1.000	1.000
421	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(21), GNAS(38), GNB1(2), GNGT1(3), PPP2CA(4), PRKAA1(7), PRKAA2(10), PRKAB2(4), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	8696280	140	85	133	37	55	13	12	24	34	2	0.220	1.000	1.000
422	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(5), CREBBP(46), DUSP1(3), EP300(27), IKBKB(10), IL1B(4), MAP2K3(11), MAP2K6(1), MAP3K7(11), MAPK11(1), MAPK14(2), MYD88(4), NFKB1(8), NFKBIA(1), NR3C1(9), RELA(7), TGFBR1(8), TLR2(4), TNF(3)	16676225	165	85	160	46	43	19	22	33	48	0	0.150	1.000	1.000
423	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), EPX(16), GOT1(3), GOT2(2), HPD(4), LPO(11), MAOA(4), MAOB(3), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), TAT(5), TPO(27)	12255002	146	85	136	42	44	13	15	37	36	1	0.316	1.000	1.000
424	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), BCL2(4), EGFR(19), IGF1R(20), MYC(6), POLR2A(24), PPP2CA(4), PRKCA(8), RB1(14), TEP1(37), TERF1(8), TERT(9), TNKS(21), XRCC5(10)	16058197	187	85	181	75	52	29	33	30	43	0	0.744	1.000	1.000
425	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(21), AKT1(3), ASAH1(4), GNAI1(3), GNB1(2), GNGT1(3), ITGAV(18), ITGB3(6), MAPK1(3), MAPK3(3), PDGFA(2), PDGFRA(13), PIK3R1(12), PLCB1(21), PRKCA(8), PTK2(11), RAC1(1), SMPD1(6), SMPD2(3), SPHK1(10), SRC(5)	14810494	158	84	151	47	43	20	25	24	44	2	0.217	1.000	1.000
426	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(2), CALM2(3), CALM3(1), CDKN1A(5), GNAQ(3), MARCKS(2), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), SP1(5), SP3(5), SYT1(5)	12309203	149	83	142	36	59	24	15	19	32	0	0.00258	1.000	1.000
427	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(17), EPHB1(33), FYN(9), ITGA1(7), ITGB1(11), L1CAM(18), LYN(7), RAP1B(6), SELP(11)	9261404	123	82	119	38	46	12	15	36	13	1	0.136	1.000	1.000
428	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(19), IL13(4), IL4(4), JUNB(5), MAF(4), MAP2K3(11), MAPK14(2), NFATC1(16), NFATC2(26), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	7104277	130	82	121	42	46	19	12	16	37	0	0.119	1.000	1.000
429	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(4), ALDH18A1(9), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AMD1(7), AOC2(10), AOC3(13), ARG1(2), ARG2(3), ASL(5), ASS1(10), CPS1(24), GATM(3), MAOA(4), MAOB(3), NAGS(1), ODC1(3), OTC(4), SAT1(2), SMS(6), SRM(1)	17246108	174	82	163	35	43	18	27	38	48	0	0.00790	1.000	1.000
430	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(14), BST1(3), CD38(5), ENPP1(7), ENPP3(12), NADK(11), NADSYN1(11), NMNAT1(4), NMNAT2(1), NMNAT3(3), NNMT(3), NNT(10), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT12(6)	12611311	130	82	120	42	32	16	20	20	41	1	0.433	1.000	1.000
431	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(6), ANXA2(3), ANXA3(1), ANXA4(6), ANXA5(4), ANXA6(3), CYP11A1(6), EDN1(4), EDNRA(4), HPGD(3), HSD11B1(4), HSD11B2(4), PLA2G4A(7), PRL(1), PTGDR(8), PTGDS(1), PTGER2(7), PTGER4(12), PTGFR(5), PTGIS(8), PTGS1(13), PTGS2(7), S100A6(1), SCGB1A1(3), TBXAS1(7)	11562659	128	82	125	45	33	12	21	33	28	1	0.612	1.000	1.000
432	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(7), ABAT(4), ADSL(5), ADSS(6), AGXT(3), AGXT2(13), ASL(5), ASNS(5), ASPA(2), CAD(20), CRAT(12), DARS(2), DDO(6), GAD1(8), GAD2(15), GOT1(3), GOT2(2), GPT(4), GPT2(3), NARS(5), PC(18)	15266820	148	81	142	57	52	20	17	26	33	0	0.621	1.000	1.000
433	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(7), CARS(6), DARS(2), EPRS(18), FARS2(9), GARS(3), HARS(9), IARS(11), KARS(7), LARS(9), LARS2(10), MARS(7), MARS2(5), NARS(5), QARS(7), RARS(5), SARS(9), TARS(11), WARS(4), WARS2(12), YARS(8)	18803806	164	81	159	44	47	21	28	30	38	0	0.109	1.000	1.000
434	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG12(3), ATG5(3), ATG7(9), BECN1(8), GABARAPL1(6), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(16), PIK3R4(10), PRKAA1(7), PRKAA2(10), ULK1(20), ULK2(11), ULK3(2)	12123262	134	81	127	35	26	18	18	38	33	1	0.241	1.000	1.000
435	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(8), CBS(9), CTH(3), GGT1(9), HEMK1(1), LCMT1(1), LCMT2(11), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), METTL6(5), PAPSS1(6), PAPSS2(6), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SCLY(4), SEPHS1(4), SEPHS2(3), WBSCR22(5)	14594112	142	80	134	45	36	18	24	23	40	1	0.275	1.000	1.000
436	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(4), ASNS(5), ASRGL1(4), CA1(1), CA12(1), CA13(4), CA14(5), CA2(7), CA3(4), CA4(6), CA5A(3), CA5B(1), CA6(3), CA7(3), CA8(4), CA9(7), CPS1(24), CTH(3), GLS(11), GLS2(8), GLUD1(4), GLUD2(13), GLUL(5), HAL(4)	12455509	134	79	128	41	30	15	25	34	30	0	0.385	1.000	1.000
437	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), INSR(17), IRS1(27), JUN(5), MAPK3(3), MAPK8(6), PIK3R1(12), PTPN11(8), RAF1(9), RASA1(19), SHC1(7), SLC2A4(5), SOS1(9), SRF(5)	13194045	147	79	138	34	34	21	15	23	50	4	0.0390	1.000	1.000
438	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(7), CCR2(5), CCR3(12), CCR5(4), CCR7(4), CD28(1), CD4(11), CXCR3(2), IFNG(2), IFNGR1(10), IFNGR2(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18R1(6), IL4(4), IL4R(7), TGFB1(3), TGFB2(9), TGFB3(9)	11727453	123	79	115	40	29	11	19	29	35	0	0.542	1.000	1.000
439	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(46), EP300(27), LPL(9), NCOA1(20), NCOA2(27), PPARG(4), RXRA(13)	10837065	146	79	139	35	45	22	21	29	29	0	0.0201	1.000	1.000
440	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(11), F2R(6), F2RL3(4), GNAI1(3), GNB1(2), GNGT1(3), HRAS(1), ITGA1(7), ITGB1(11), MAPK1(3), MAPK3(3), PLA2G4A(7), PLCB1(21), PRKCA(8), PTGS1(13), PTK2(11), RAF1(9), SRC(5), SYK(9), TBXAS1(7)	13828813	144	79	138	34	50	14	18	32	29	1	0.0181	1.000	1.000
441	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(5), BIRC2(7), BIRC3(10), CASP3(2), CFLAR(1), FADD(3), JUN(5), MAP2K4(9), MAP3K3(9), MAP3K7(11), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR2C2(6), RALBP1(10), RIPK1(3), TNF(3), TNFAIP3(11), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4)	15271150	142	79	139	32	38	20	16	27	38	3	0.0453	1.000	1.000
442	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(25), APOA1(8), APOA4(8), APOC2(2), APOE(2), CETP(7), CYP7A1(7), DGAT1(10), HMGCR(7), LCAT(4), LDLR(12), LIPC(5), LPL(9), LRP1(54), SCARB1(4), SOAT1(11)	16067661	175	79	167	53	63	16	26	32	36	2	0.200	1.000	1.000
443	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(21), AKT1(3), BAD(4), BAX(1), BCL2(4), BCL2L1(1), CSF2RB(12), IGF1(2), IGF1R(20), IL3(1), IL3RA(5), KIT(13), KITLG(4), PIK3R1(12), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), YWHAH(3)	11573361	145	78	141	64	40	23	21	26	33	2	0.857	1.000	1.000
444	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(8), CREB1(4), CREBBP(46), EP300(27), NCOA3(15), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RARA(4), RXRA(13)	12122086	156	78	148	45	48	20	21	23	44	0	0.146	1.000	1.000
445	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(21), ADRB2(8), GNAS(38), PLCE1(17), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9)	8699774	123	78	117	46	50	15	12	21	24	1	0.687	1.000	1.000
446	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(14), AP2M1(8), ARF1(5), BAD(4), BTK(4), EEA1(15), GRASP(2), GSK3A(4), GSK3B(6), LYN(7), PDPK1(1), PFKL(8), PFKM(2), PFKP(21), PLCG1(22), PRKCE(14), PRKCZ(2), RAB5A(3), RAC1(1), RPS6KB1(6), VAV2(13)	14633280	165	78	159	49	57	25	20	24	38	1	0.143	1.000	1.000
447	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(4), ARSB(2), ARSD(5), ARSE(6), CYP11B1(17), CYP11B2(8), HSD11B1(4), HSD11B2(4), HSD17B2(3), HSD17B3(2), HSD3B1(4), HSD3B2(2), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5)	15957014	133	77	128	51	33	29	16	27	28	0	0.583	1.000	1.000
448	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	13	AANAT(2), ACHE(15), CHAT(6), COMT(5), DBH(7), GAD1(8), GAD2(15), HDC(11), MAOA(4), PAH(6), SLC18A3(16), TH(7), TPH1(4)	7553990	106	77	106	46	37	11	10	25	23	0	0.741	1.000	1.000
449	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	28	AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), AGPS(6), CHPT1(4), ENPP2(11), ENPP6(7), PAFAH1B2(1), PAFAH1B3(2), PAFAH2(4), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLD1(22), PLD2(19), PPAP2A(3), PPAP2B(2), PPAP2C(6)	12919802	149	77	149	39	46	19	28	32	24	0	0.0401	1.000	1.000
450	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IGF1(2), IGF1R(20), IRS1(27), JUN(5), MAPK3(3), MAPK8(6), PIK3R1(12), PTPN11(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5)	12803546	147	77	138	43	35	18	16	27	48	3	0.327	1.000	1.000
451	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(6), BCAT2(9), IARS(11), IARS2(12), ILVBL(8), LARS(9), LARS2(10), PDHA1(1), PDHA2(11), PDHB(4), VARS(23), VARS2(14)	10887719	118	76	116	37	34	14	17	30	23	0	0.387	1.000	1.000
452	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(4), B3GNT2(5), B3GNT7(6), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), CHST1(20), CHST2(15), CHST4(7), CHST6(11), FUT8(9), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7)	7319452	119	76	114	41	59	11	13	16	20	0	0.402	1.000	1.000
453	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ACAA2(9), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1C4(5), AKR1D1(4), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), BAAT(6), CEL(16), CYP27A1(6), CYP7A1(7), HADHB(6), SOAT2(3), SRD5A1(2)	13605777	159	75	147	43	33	19	29	30	48	0	0.150	1.000	1.000
454	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(5), CSF1R(17), EGF(11), EGFR(19), GRB2(4), MET(10), PDGFRA(13), PRKCA(8), SH3GLB1(3), SH3GLB2(8), SH3KBP1(17), SRC(5)	11398215	120	75	112	56	32	18	9	26	35	0	0.977	1.000	1.000
455	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(21), ADRB2(8), CFTR(15), GNAS(38), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), SLC9A3R1(1)	7688595	122	75	116	35	46	12	11	22	30	1	0.355	1.000	1.000
456	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(10), RPE(5), UGDH(8), UGP2(9), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), XYLB(6)	15889679	140	75	132	30	20	15	26	33	46	0	0.0607	1.000	1.000
457	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(8), FUCA1(1), FUCA2(2), GLB1(7), HEXA(2), HEXB(3), LCT(24), MAN2B1(19), MAN2B2(19), MAN2C1(11), MANBA(10), NEU1(3), NEU2(7), NEU3(5), NEU4(3)	11920709	124	75	120	31	42	18	17	18	29	0	0.0481	1.000	1.000
458	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(3), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), HGSNAT(5), HPSE(11), HPSE2(10), HYAL1(7), HYAL2(8), IDS(4), IDUA(4), LCT(24), NAGLU(8), SPAM1(10)	11967757	126	75	124	39	37	25	20	19	25	0	0.219	1.000	1.000
459	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(6), GPLD1(13), PGAP1(11), PIGA(3), PIGB(10), PIGC(6), PIGG(15), PIGK(3), PIGL(5), PIGM(4), PIGN(6), PIGO(10), PIGP(1), PIGQ(9), PIGS(4), PIGT(11), PIGV(7), PIGW(5), PIGX(3), PIGZ(10)	13899980	142	75	129	39	34	15	17	32	43	1	0.295	1.000	1.000
460	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(4), BLVRB(1), CP(10), CPOX(4), EPRS(18), FECH(7), GUSB(10), HCCS(4), HMBS(3), HMOX1(7), HMOX2(1), PPOX(6), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5), UROD(2), UROS(5)	16012915	136	75	131	44	30	21	16	31	38	0	0.505	1.000	1.000
461	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(5), CREBBP(46), EP300(27), FADD(3), HDAC3(7), IKBKB(10), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6)	13090035	137	75	132	38	42	21	14	24	36	0	0.125	1.000	1.000
462	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(11), ACE2(11), AGT(4), AGTR1(1), AGTR2(4), ANPEP(10), CMA1(2), CPA3(4), CTSA(5), CTSG(4), ENPEP(15), LNPEP(12), MAS1(3), MME(10), NLN(7), REN(7), THOP1(6)	12388106	116	74	113	42	32	14	18	24	28	0	0.613	1.000	1.000
463	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IL2RA(2), IL2RB(3), IL2RG(9), JAK1(19), JAK3(12), JUN(5), LCK(4), MAPK3(3), MAPK8(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13), SYK(9)	13180853	135	74	127	31	29	22	14	30	38	2	0.0728	1.000	1.000
464	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(3), CHUK(5), CRADD(6), IKBKB(10), JUN(5), LTA(4), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP4K2(10), MAPK14(2), MAPK8(6), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TANK(3), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4)	14086534	125	74	122	37	31	17	14	18	43	2	0.291	1.000	1.000
465	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(3), EIF4A1(3), EIF4A2(6), EIF4B(5), EIF4E(2), EIF4EBP1(4), EIF4G1(25), EIF4G3(22), FKBP1A(2), MKNK1(5), PDK2(1), PDPK1(1), PIK3R1(12), PPP2CA(4), RPS6(1), RPS6KB1(6), TSC1(10), TSC2(14)	14415997	126	73	121	33	35	12	23	22	32	2	0.223	1.000	1.000
466	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(4), ARSB(2), ARSD(5), ARSE(6), ASAH1(4), GAL3ST1(12), GALC(5), GBA(12), GLA(3), GLB1(7), LCT(24), NEU1(3), NEU2(7), NEU3(5), NEU4(3), PPAP2A(3), PPAP2B(2), PPAP2C(6), SMPD1(6), SMPD2(3), SPTLC1(5), SPTLC2(4), UGCG(3)	14163863	134	72	130	51	43	18	25	20	28	0	0.673	1.000	1.000
467	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), ZNRD1(2)	13759882	124	72	121	36	40	13	22	25	24	0	0.167	1.000	1.000
468	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(5), ELK1(4), EPO(3), EPOR(3), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAPK3(3), MAPK8(6), PLCG1(22), PTPN6(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13)	12152445	123	71	121	30	36	19	15	23	29	1	0.0500	1.000	1.000
469	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), G6PD(6), GPI(6), H6PD(7), PFKL(8), PFKM(2), PFKP(21), PGD(8), PGLS(1), PGM1(3), PGM3(13), PRPS1(3), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TALDO1(6), TKT(5), TKTL1(11), TKTL2(12)	14222969	152	70	144	44	40	30	18	32	32	0	0.0567	1.000	1.000
470	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	AKR1B10(6), ALOX15(10), ALOX5(11), CYP1A2(5), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2J2(4), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), HSD3B7(7), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), RDH11(1), RDH12(3), RDH13(7)	13839791	126	70	125	46	46	14	23	23	19	1	0.559	1.000	1.000
471	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(4), B3GNT2(5), B3GNT3(3), B3GNT4(9), B3GNT5(11), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), FUT1(5), FUT2(2), FUT3(4), FUT4(2), FUT5(3), FUT6(6), FUT7(3), FUT9(7), GCNT2(1), ST3GAL6(6), ST8SIA1(12)	9479775	102	70	95	38	30	13	12	21	26	0	0.781	1.000	1.000
472	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(8), B4GALNT1(4), GLB1(7), HEXA(2), HEXB(3), LCT(24), SLC33A1(5), ST3GAL1(5), ST3GAL2(9), ST3GAL5(2), ST6GALNAC3(6), ST6GALNAC4(3), ST6GALNAC5(9), ST6GALNAC6(4), ST8SIA1(12), ST8SIA5(8)	9662814	111	70	108	44	43	12	15	20	21	0	0.723	1.000	1.000
473	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IL6R(3), IL6ST(6), JAK1(19), JAK2(12), JAK3(12), JUN(5), MAPK3(3), PTPN11(8), RAF1(9), SHC1(7), SOS1(9), SRF(5), STAT3(7)	13539855	120	70	113	38	25	19	15	30	28	3	0.454	1.000	1.000
474	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37)	9812143	112	69	109	39	32	19	11	15	35	0	0.647	1.000	1.000
475	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(17), DDX20(3), E2F1(4), E2F4(2), ETS1(8), ETS2(4), ETV3(1), FOS(1), HDAC2(6), HDAC5(13), HRAS(1), JUN(5), NCOR2(40), RBL1(12), RBL2(7), SIN3A(15), SIN3B(15)	15152563	159	69	156	39	46	17	21	30	42	3	0.0876	1.000	1.000
476	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), AOC2(10), AOC3(13), ASPA(2), CNDP1(5), HAL(4), HARS(9), HDC(11), HNMT(2), MAOA(4), MAOB(3), PRPS1(3), PRPS2(3)	13719175	147	69	136	38	38	12	19	28	50	0	0.256	1.000	1.000
477	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(14), ABCC2(17), ABCG2(5), BCHE(19), CES2(9), CYP3A4(3), CYP3A5(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3)	12901412	109	69	102	27	20	16	15	23	35	0	0.162	1.000	1.000
478	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGAM(10), ITGB1(11), ITGB2(12), SELE(6), SELL(6), SELP(11)	9332300	106	69	101	35	35	5	13	28	25	0	0.263	1.000	1.000
479	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(4), ASNS(5), CA1(1), CA12(1), CA14(5), CA2(7), CA3(4), CA4(6), CA5A(3), CA5B(1), CA6(3), CA7(3), CA8(4), CA9(7), CPS1(24), CTH(3), GLS(11), GLS2(8), GLUD1(4), GLUL(5), HAL(4)	11147941	113	69	107	35	24	13	22	26	28	0	0.467	1.000	1.000
480	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(7), ACO2(11), CS(1), DLD(10), DLST(6), FH(4), IDH1(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), PC(18), PCK1(12), SDHA(11), SDHB(4), SUCLA2(3), SUCLG1(2), SUCLG2(8)	12082327	116	68	110	37	43	18	10	15	30	0	0.288	1.000	1.000
481	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(8), F2(11), F2R(6), F3(2), F5(22), F7(11), FGA(12), FGB(6), FGG(5), PROC(4), PROS1(11), SERPINC1(5), TFPI(5)	9627975	108	68	107	31	30	15	15	31	17	0	0.248	1.000	1.000
482	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CYP2C19(8), CYP2C9(1), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ECHS1(2), EHHADH(4), ESCO1(10), ESCO2(10), HADHA(5), NAT6(4), PNPLA3(4), SH3GLB1(3), YOD1(1)	18120585	133	68	121	34	32	14	16	22	49	0	0.246	1.000	1.000
483	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22(2), IL22RA1(2), IL22RA2(1), JAK1(19), JAK2(12), JAK3(12), SOCS3(3), STAT1(11), STAT3(7), STAT5A(10), STAT5B(13), TYK2(12)	10743415	109	68	105	35	27	15	13	20	31	3	0.552	1.000	1.000
484	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(5), ARFGAP1(5), ARFGAP3(6), ARFGEF2(31), CLTA(2), CLTB(2), COPA(13), GBF1(22), GPLD1(13), KDELR1(2), KDELR2(3), KDELR3(2)	9535763	106	67	106	29	33	18	16	20	19	0	0.0934	1.000	1.000
485	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(5), CR2(25), FCGR2B(3), HLA-DRA(7), HLA-DRB1(1), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21)	7052250	100	67	88	34	29	11	11	21	28	0	0.563	1.000	1.000
486	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(14), AMT(4), ATIC(5), FTCD(7), GART(10), MTFMT(2), MTHFD1(7), MTHFD1L(8), MTHFD2(1), MTHFR(10), MTHFS(3), MTR(19), SHMT1(2), SHMT2(11), TYMS(1)	11082523	104	67	100	28	27	14	14	21	27	1	0.0689	1.000	1.000
487	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), MDH1(3), ME1(1), ME3(7), PGK1(4), PGK2(3), PKLR(9), RPE(5), RPIA(2), TKT(5), TKTL1(11), TKTL2(12), TPI1(3)	11828319	104	67	103	57	30	24	12	21	17	0	0.978	1.000	1.000
488	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(5), HSPA1A(4), IFNG(2), IFNGR1(10), IFNGR2(2), IKBKB(10), JAK2(12), LIN7A(9), NFKB1(8), NFKBIA(1), RB1(14), RELA(7), TNF(3), TNFRSF1A(6), TNFRSF1B(3), USH1C(8), WT1(5)	10152409	109	67	107	39	26	17	12	24	29	1	0.621	1.000	1.000
489	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(4), BAX(1), BCL2(4), FADD(3), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), NFKB1(8), NSMAF(10), RAF1(9), RELA(7), RIPK1(3), SMPD1(6), TNFRSF1A(6), TRADD(2), TRAF2(4)	10875561	104	66	98	28	34	16	7	10	34	3	0.131	1.000	1.000
490	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(6), GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), GPHN(13), NSF(2), SRC(5), UBQLN1(6)	7007410	102	66	99	31	21	10	23	35	13	0	0.328	1.000	1.000
491	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT5(4), DPAGT1(6), DPM1(2), FUT8(9), MAN1A1(4), MAN1B1(6), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), RPN1(4), RPN2(6), ST6GAL1(1)	11666192	100	66	97	38	31	13	11	20	25	0	0.700	1.000	1.000
492	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(16), LPO(11), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), TPO(27), TYR(15)	5631167	83	66	78	26	27	10	8	25	12	1	0.404	1.000	1.000
493	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(8), ARHGDIB(1), BIRC2(7), BIRC3(10), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP9(3), DFFA(4), DFFB(3), GZMB(2), LMNA(11), LMNB1(4), LMNB2(6), PRF1(13)	10629527	100	65	98	29	26	13	16	20	25	0	0.396	1.000	1.000
494	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8), MASP1(3), MASP2(6), MBL2(4)	12484355	114	65	108	33	35	15	13	23	28	0	0.223	1.000	1.000
495	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), AMD1(7), BHMT(5), CBS(9), CTH(3), DNMT1(19), DNMT3A(7), DNMT3B(15), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), MTAP(2), MTFMT(2), MTR(19), SRM(1), TAT(5)	12127607	121	65	119	53	37	14	25	25	20	0	0.862	1.000	1.000
496	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(5), FADD(3), IKBKB(10), IL1A(2), IL1R1(4), IRAK1(7), MAP3K1(16), MAP3K7(11), MYD88(4), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TNF(3), TNFAIP3(11), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6)	13234221	112	65	109	27	32	17	9	17	37	0	0.0709	1.000	1.000
497	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(8), GALNT2(7), GALNT3(4), GALNT4(6), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GCNT1(1), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), WBSCR17(27)	8464373	97	65	94	36	39	8	13	18	18	1	0.821	1.000	1.000
498	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), G6PD(6), GPI(6), H6PD(7), PFKM(2), PFKP(21), PGD(8), PGLS(1), PGM1(3), PGM3(13), PRPS1(3), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TAL1(5), TALDO1(6), TKT(5)	11985956	126	65	119	35	33	24	14	28	27	0	0.0534	1.000	1.000
499	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(10), CCNB1(3), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNH(3), CDC25A(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2B(1), CDKN2C(1), CDKN2D(4), E2F1(4), RB1(14), RBL1(12), TFDP1(5)	9085725	88	64	87	29	17	18	13	19	21	0	0.439	1.000	1.000
500	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C8B(11), C9(8), MASP1(3)	12189996	115	64	109	30	36	13	15	26	25	0	0.127	1.000	1.000
501	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(10), G6PD(6), GCLC(3), GCLM(3), GGT1(9), GPX5(2), GPX7(3), GSR(5), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), IDH1(4), IDH2(4), MGST1(3), MGST2(3), MGST3(3), OPLAH(25), TXNDC12(3)	12868773	115	64	107	39	32	17	11	23	31	1	0.675	1.000	1.000
502	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(13), CNR2(3), DNMT1(19), MTNR1A(4), MTNR1B(8), PTAFR(4), PTGDR(8), PTGER2(7), PTGER4(12), PTGFR(5), TBXA2R(9)	6518288	92	64	88	43	39	12	15	16	10	0	0.682	1.000	1.000
503	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(4), JAK1(19), JAK2(12), JAK3(12), PIAS1(10), PIAS3(10), PTPRU(26), REG1A(4), SOAT1(11)	8022420	108	64	96	32	31	16	9	12	37	3	0.551	1.000	1.000
504	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(5), DUSP1(3), IKBKAP(14), IKBKB(10), LTA(4), MAP3K1(16), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TANK(3), TNFAIP3(11), TNFRSF1B(3), TRAF1(4), TRAF2(4), TRAF3(7)	13153352	103	64	99	33	32	14	8	15	33	1	0.460	1.000	1.000
505	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), MDH1(3), ME1(1), ME2(7), ME3(7), PGK1(4), PKLR(9), RPE(5), RPIA(2), TKT(5), TPI1(3)	10571491	85	63	85	46	22	20	10	16	17	0	0.964	1.000	1.000
506	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(8), AGT(4), AGTR2(4), EDN1(4), EDNRA(4), EGF(11), EGFR(19), FOS(1), HRAS(1), JUN(5), MYC(6), NFKB1(8), PLCG1(22), PRKCA(8), RELA(7)	11518996	112	63	108	35	33	18	10	27	24	0	0.230	1.000	1.000
507	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	20	ANPEP(10), CD2(4), CD33(9), CD5(4), CD7(5), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(3), IL12B(2), IL13(4), IL3(1), IL4(4), ITGAX(13), TLR2(4), TLR7(6), TLR9(15)	9913435	92	63	89	37	32	12	10	22	16	0	0.532	1.000	1.000
508	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(11), EGFR(19), MAP3K1(16), MAPK14(2), NCOR2(40), RARA(4), RXRA(13), THRA(7), THRB(4)	9630004	116	63	110	37	47	13	11	17	25	3	0.359	1.000	1.000
509	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(3), CREB1(4), GRB2(4), HRAS(1), MAPK1(3), MAPK3(3), MAPK7(8), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), NTRK1(9), PIK3R1(12), PLCG1(22), RPS6KA1(9), SHC1(7)	9801531	106	63	103	28	33	17	15	15	25	1	0.0682	1.000	1.000
510	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(9), ACP2(5), ACP5(3), ACP6(3), ACPP(5), ACPT(6), ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), PON1(3), PON2(3), PON3(5)	10574025	107	63	99	44	37	11	12	20	27	0	0.812	1.000	1.000
511	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(10), AKT3(8), BPNT1(6), GRB2(4), ILK(9), MAPK1(3), MAPK3(3), PDK1(3), PIK3CD(15), PTK2B(16), RBL2(7), SHC1(7), SOS1(9)	10210832	103	63	100	27	37	13	9	21	23	0	0.249	1.000	1.000
512	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(4), IL6R(3), JAK1(19), JAK2(12), JAK3(12), PIAS3(10), PTPRU(26), REG1A(4), SRC(5), STAT3(7)	8918107	102	63	94	31	31	15	9	16	28	3	0.434	1.000	1.000
513	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(4), CHRNB1(4), CHRNG(8), MUSK(16), PIK3R1(12), PTK2(11), PTK2B(16), RAPSN(3), SRC(5), TERT(9), YWHAH(3)	8282541	94	61	92	33	31	11	14	17	20	1	0.434	1.000	1.000
514	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(9), CLOCK(8), CRY1(3), CRY2(7), CSNK1D(4), CSNK1E(9), NPAS2(14), NR1D1(9), PER1(6), PER2(15), PER3(13)	9979085	97	61	94	27	33	12	10	18	24	0	0.149	1.000	1.000
515	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(3), CCND1(2), CCNE1(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), E2F1(4), HRAS(1), MAPK1(3), MAPK3(3), NFKB1(8), NFKBIA(1), PAK1(5), PIK3R1(12), RAC1(1), RAF1(9), RB1(14), RELA(7), TFDP1(5)	10577569	99	61	97	28	19	16	17	16	30	1	0.259	1.000	1.000
516	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(4), CHUK(5), IFNG(2), IKBKB(10), IL4(4), JUN(5), MAP3K1(16), MAP3K5(10), MAP4K5(4), MAPK14(2), MAPK8(6), NFKB1(8), NFKBIA(1), RELA(7), TNFRSF9(11), TRAF2(4)	11327837	99	60	91	22	25	11	7	17	38	1	0.131	1.000	1.000
517	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(17), KHK(2), LCT(24), MPI(3), PGM1(3), PYGL(11), PYGM(14), TPI1(3), TREH(3)	7844858	80	60	79	28	34	15	7	10	14	0	0.292	1.000	1.000
518	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(3), CREB1(4), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), NFKB1(8), PIK3R1(12), RB1(14), RELA(7), SP1(5)	9632007	92	60	88	29	17	10	18	12	34	1	0.476	1.000	1.000
519	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(2), MRPS7(1), RPL10A(6), RPL11(1), RPL12(3), RPL13A(4), RPL14(2), RPL18(1), RPL18A(1), RPL19(1), RPL22L1(1), RPL23A(3), RPL24(2), RPL26(1), RPL27(1), RPL28(1), RPL29(2), RPL3(3), RPL31(2), RPL34(1), RPL35A(1), RPL36A(3), RPL37(1), RPL38(1), RPL3L(3), RPL6(3), RPL8(3), RPL9(4), RPS10(1), RPS11(1), RPS13(2), RPS16(1), RPS18(1), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(1), RPS26(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS7(1), RPS9(2), RPSA(5)	13001692	91	60	87	39	21	13	13	18	26	0	0.983	1.000	1.000
520	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF4E(2), EIF4EBP1(4), GSK3B(6), IGF1(2), IGF1R(20), INPPL1(27), PDK2(1), PDPK1(1), PIK3R1(12), PPP2CA(4), RPS6(1), RPS6KB1(6)	9758644	104	60	94	36	29	8	17	17	31	2	0.784	1.000	1.000
521	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(3), BAD(4), GRB2(4), HRAS(1), IGF1R(20), IRS1(27), MAPK1(3), MAPK3(3), PIK3R1(12), RAF1(9), SHC1(7), SOS1(9), YWHAH(3)	9398207	105	60	100	38	29	14	15	15	30	2	0.728	1.000	1.000
522	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3E(2), CXCR3(2), ETV5(7), IFNG(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18(1), IL18R1(6), JAK2(12), JUN(5), MAP2K6(1), MAPK14(2), MAPK8(6), STAT4(9), TYK2(12)	10910334	95	60	95	31	18	15	18	19	24	1	0.410	1.000	1.000
523	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(8), FUCA1(1), FUCA2(2), GLB1(7), HEXA(2), HEXB(3), LCT(24), MAN2C1(11), MANBA(10), NEU1(3), NEU2(7), NEU3(5), NEU4(3)	9669989	86	60	85	29	26	15	10	13	22	0	0.526	1.000	1.000
524	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(10), E2F1(4), MDM2(8), MYC(6), PIK3R1(12), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), RAC1(1), RB1(14), TBX2(10), TWIST1(3)	9801492	103	59	98	29	27	7	18	15	34	2	0.233	1.000	1.000
525	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(5), FUT1(5), FUT2(2), FUT9(7), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), ST8SIA1(12)	5935240	72	59	69	27	31	7	6	20	8	0	0.520	1.000	1.000
526	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(10), B3GAT2(7), B3GAT3(4), B4GALT7(6), CHPF(4), CHST11(4), CHST12(6), CHST13(5), CHST14(2), CHST3(8), CHST7(7), CHSY1(9), DSE(8), UST(10), XYLT1(11)	7270878	101	59	95	39	51	9	16	14	11	0	0.567	1.000	1.000
527	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(14), CD38(5), ENPP1(7), ENPP3(12), NADSYN1(11), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(10), NT5E(5), NT5M(6)	8519417	78	59	72	28	9	9	14	16	29	1	0.783	1.000	1.000
528	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(5), B3GALNT1(5), B3GALT5(2), FUT1(5), FUT2(2), FUT9(7), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(5), ST3GAL2(9), ST8SIA1(12)	6300423	72	58	68	32	29	7	6	20	10	0	0.815	1.000	1.000
529	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(12), FOS(1), GRB2(4), HRAS(1), IL3(1), IL3RA(5), JAK2(12), MAPK3(3), PTPN6(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13)	9918921	93	57	91	32	26	15	12	19	20	1	0.538	1.000	1.000
530	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(4), IL2RG(9), IL4(4), IL4R(7), IRS1(27), JAK1(19), JAK3(12), RPS6KB1(6), SHC1(7), STAT6(7)	8642708	105	57	93	28	23	13	12	11	43	3	0.628	1.000	1.000
531	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(5), CBS(9), CTH(3), DNMT1(19), DNMT3A(7), DNMT3B(15), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), MTR(19)	10172520	104	57	102	45	35	10	22	18	19	0	0.819	1.000	1.000
532	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(4), CD2(4), CD3E(2), CD4(11), CXCR3(2), IFNG(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), JAK2(12), STAT4(9), TYK2(12)	8587845	82	57	77	33	15	12	15	16	23	1	0.865	1.000	1.000
533	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(3), AKT2(10), AKT3(8), CDKN1A(5), ELK1(4), GRB2(4), HRAS(1), MAP2K2(3), NGFR(7), NTRK1(9), PIK3CD(15), SHC1(7), SOS1(9)	7710592	85	57	82	37	32	11	9	22	11	0	0.822	1.000	1.000
534	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(21), CREM(6), FHL5(5), FSHB(1), GNAS(38), XPO1(13)	4814768	84	56	77	23	39	11	5	19	9	1	0.367	1.000	1.000
535	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP27B1(9), CYP51A1(9), DHCR24(4), DHCR7(7), EBP(2), FDFT1(3), FDPS(12), GGCX(4), GGPS1(4), HMGCR(7), HSD17B7(5), IDI1(2), IDI2(3), LSS(14), MVD(2), NQO1(3), NSDHL(4), PMVK(1), SQLE(9), TM7SF2(4), VKORC1(1)	10773893	109	56	104	31	28	11	13	23	34	0	0.441	1.000	1.000
536	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(5), DUSP1(3), IKBKAP(14), IKBKB(10), MAP3K1(16), NFKB1(8), NFKBIA(1), RELA(7), TNFAIP3(11), TRAF3(7), TRAF6(6)	10622692	88	55	84	24	27	10	7	13	31	0	0.348	1.000	1.000
537	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(6), ACAT2(5), ACOT11(5), ACYP1(1), ACYP2(3), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ECHS1(2), EHHADH(4), ESCO1(10), ESCO2(10), FN3K(4), GCDH(7), HADHA(5), NAT6(4), PNPLA3(4), SH3GLB1(3), YOD1(1)	15238840	93	55	87	17	19	13	14	11	36	0	0.0353	1.000	1.000
538	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(9), ARG1(2), ARG2(3), ASL(5), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), GAMT(1), GATM(3), GLUD1(4), NAGS(1), OAT(3), ODC1(3), OTC(4), PYCR1(3), SMS(6)	10237158	92	55	92	27	30	9	14	24	15	0	0.191	1.000	1.000
539	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(5), ACAD9(8), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ESCO1(10), ESCO2(10), NAT6(4), PNPLA3(4), SH3GLB1(3)	14646158	92	54	89	15	21	8	16	18	29	0	0.0109	1.000	1.000
540	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(8), ESR2(9), ITPKA(2), PDE1A(7), PDE1B(5), PLCB1(21), PLCB2(8), PRL(1), TRH(5), VIP(7)	6511891	73	54	70	28	23	10	11	19	10	0	0.628	1.000	1.000
541	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(1), CD3E(2), CD4(11), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21), THY1(1)	6611545	78	54	69	35	19	7	10	19	23	0	0.934	1.000	1.000
542	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(10), G6PD(6), GCLC(3), GCLM(3), GGT1(9), GPX5(2), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), IDH1(4), IDH2(4), MGST1(3), MGST2(3), MGST3(3), PGD(8)	10549227	84	53	80	28	23	15	8	18	20	0	0.544	1.000	1.000
543	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(3), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), IDS(4), IDUA(4), LCT(24), NAGLU(8)	8396178	75	52	74	30	22	14	10	12	17	0	0.655	1.000	1.000
544	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	18	AKT1(3), BAD(4), BCL2L1(1), CASP9(3), CDC42(3), CHUK(5), ELK1(4), HRAS(1), MAPK3(3), NFKB1(8), PIK3R1(12), RAC1(1), RAF1(9), RALBP1(10), RALGDS(14), RELA(7)	9196376	88	52	85	25	26	12	13	12	24	1	0.218	1.000	1.000
545	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(1), CD3E(2), CD8A(4), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21), THY1(1)	6301491	71	52	67	30	19	7	11	17	17	0	0.743	1.000	1.000
546	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(3), ACOX3(13), ELOVL2(7), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(4), FASN(27), HADHA(5), HSD17B12(4), PECR(1), SCD(1)	8331084	73	51	66	30	29	8	12	6	18	0	0.697	1.000	1.000
547	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(9), DLL1(16), FURIN(6), NOTCH1(31), PSEN1(5)	5399864	67	51	64	31	21	8	7	13	18	0	0.779	1.000	1.000
548	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(15), EGF(11), EGFR(19), HGS(5), RAB5A(3), TF(15), TFRC(2)	7533894	70	50	68	32	20	10	6	19	14	1	0.887	1.000	1.000
549	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACADM(7), ACADS(4), ACADVL(3), ACSL1(4), ACSL3(7), ACSL4(6), CPT1A(14), CPT2(7), EHHADH(4), HADHA(5), PECR(1), SCP2(5), SLC25A20(4)	9861974	74	50	71	18	19	6	11	14	24	0	0.112	1.000	1.000
550	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD4(11), FYN(9), HLA-DRA(7), HLA-DRB1(1), LCK(4), PTPRC(21), ZAP70(13)	5308172	68	50	61	32	20	8	10	18	12	0	0.939	1.000	1.000
551	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(8), ESR1(8), GREB1(26), HSPB1(2), HSPB2(1), MTA1(10), MTA3(3), PDZK1(2), TUBA8(6)	6370233	67	49	65	30	25	12	9	6	15	0	0.726	1.000	1.000
552	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(10), RPE(5), UCHL1(3), UCHL3(4), UGDH(8), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5)	10246111	87	49	82	21	19	9	17	16	26	0	0.103	1.000	1.000
553	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14)	7864391	73	49	71	25	25	9	15	11	13	0	0.374	1.000	1.000
554	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(15), CHAT(6), CHKA(2), PCYT1A(9), PDHA1(1), PDHA2(11), PEMT(1), SLC18A3(16)	4073466	61	48	61	29	25	6	7	17	6	0	0.778	1.000	1.000
555	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), NCK1(6), NCKAP1(13), NTRK1(9), PIR(1), PSMA7(3), RAC1(1), WASF1(8), WASF2(7), WASL(5)	8342438	72	48	72	31	25	8	9	11	18	1	0.842	1.000	1.000
556	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(8), ICAM1(4), ITGAL(22), ITGAM(10), ITGB2(12), SELE(6), SELL(6)	6070330	68	48	66	27	24	4	8	15	17	0	0.602	1.000	1.000
557	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(19), JAK2(12), JAK3(12), MAPK1(3), MAPK3(3), STAT3(7), TYK2(12)	6836561	68	48	64	23	14	11	10	11	19	3	0.697	1.000	1.000
558	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(4), CYP11A1(6), CYP11B1(17), CYP11B2(8), CYP17A1(7), CYP21A2(6), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2)	5430778	67	47	66	25	23	12	7	16	9	0	0.593	1.000	1.000
559	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(4), CYP11A1(6), CYP11B1(17), CYP11B2(8), CYP17A1(7), CYP21A2(6), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2)	5430778	67	47	66	25	23	12	7	16	9	0	0.593	1.000	1.000
560	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(9), CTH(3), GGT1(9), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), PAPSS1(6), PAPSS2(6), SCLY(4), SEPHS1(4)	7240494	68	47	65	27	21	8	13	9	17	0	0.635	1.000	1.000
561	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(4), IL13RA1(5), IL13RA2(7), IL4R(7), JAK1(19), JAK2(12), TYK2(12)	6138326	66	47	63	22	14	12	10	8	19	3	0.642	1.000	1.000
562	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(4), IL13RA1(5), IL13RA2(7), IL4R(7), JAK1(19), JAK2(12), TYK2(12)	6138326	66	47	63	22	14	12	10	8	19	3	0.642	1.000	1.000
563	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(11), AGT(4), AGTR1(1), AGTR2(4), BDKRB2(3), KNG1(11), NOS3(15), REN(7)	5745741	56	46	52	20	15	5	8	8	20	0	0.614	1.000	1.000
564	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(7), CDO1(3), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), MPST(3), SDS(4), SULT1B1(6), SULT1C2(2), SULT1C4(4), SULT4A1(1)	7348727	64	46	64	22	20	15	7	9	13	0	0.435	1.000	1.000
565	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(9), ENO1(3), GPI(6), HK1(17), PFKL(8), PGAM1(1), PGK1(4), PKLR(9), TPI1(3)	5416318	60	45	60	23	18	17	4	14	7	0	0.380	1.000	1.000
566	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(6), GH1(2), GHR(9), HRAS(1), IGF1(2), IGF1R(20), PIK3R1(12), SHC1(7), SOD2(2), SOD3(1)	6514017	65	45	64	27	13	11	12	14	14	1	0.762	1.000	1.000
567	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(7), CAPNS1(3), CAPNS2(2), CDK5(3), CDK5R1(5), CSNK1A1(5), CSNK1D(4), GSK3B(6), MAPT(11), PPP2CA(4)	5398060	59	44	58	19	19	12	6	11	11	0	0.285	1.000	1.000
568	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	14	CYP51A1(9), DHCR7(7), FDFT1(3), FDPS(12), HMGCR(7), HMGCS1(2), IDI1(2), LSS(14), MVD(2), NSDHL(4), PMVK(1), SQLE(9)	7211281	72	43	70	22	20	6	6	17	23	0	0.511	1.000	1.000
569	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(21), EIF2AK4(10), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF5(6), GSK3B(6), PPP1CA(2)	6782053	60	43	60	16	13	3	12	19	13	0	0.351	1.000	1.000
570	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(8), HDAC9(12), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MYOD1(7), YWHAH(3)	4522191	54	43	53	21	14	4	8	11	17	0	0.656	1.000	1.000
571	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMC3(9), PSMD14(1), RPN1(4), RPN2(6), UBE2A(1), UBE3A(5)	7567166	63	43	63	17	16	5	18	11	13	0	0.222	1.000	1.000
572	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(5), ALAS2(14), CPOX(4), FECH(7), HMBS(3), PPOX(6), UROD(2), UROS(5)	4429524	50	42	49	14	13	12	3	12	10	0	0.354	1.000	1.000
573	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(7), ACO2(11), AFMID(4), CS(1), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(8), MTHFD2(1)	7857617	59	42	58	22	17	16	5	8	13	0	0.486	1.000	1.000
574	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(6), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), HSD3B7(7), PON1(3), PON2(3), PON3(5), RDH11(1), RDH12(3), RDH13(7)	5275506	54	41	52	20	19	8	7	13	7	0	0.554	1.000	1.000
575	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX1(3), ACOX3(13), FADS2(4), PLA2G10(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8)	5751873	58	41	56	23	27	3	9	13	6	0	0.701	1.000	1.000
576	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(7), MMP2(10), MMP9(20), RECK(6), TIMP1(1), TIMP2(1), TIMP3(10), TIMP4(1)	4405603	57	41	54	28	21	12	3	9	10	2	0.820	1.000	1.000
577	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(4), ALAS1(5), ALAS2(14), CPO(4), FECH(7), GATA1(3), HBB(2), HMBS(3), UROD(2), UROS(5)	4580122	49	40	48	16	13	9	4	12	11	0	0.525	1.000	1.000
578	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(11), EGFR(19), NRG1(16)	4392770	46	40	45	23	16	10	5	9	6	0	0.822	1.000	1.000
579	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(5), ADSS(6), IMPDH1(6), MTHFD2(1), NME2(3), OAZ1(3), POLB(6), POLD1(15), POLG(10), PRPS2(3), RRM1(5), SRM(1)	7314719	64	40	63	19	20	16	5	9	14	0	0.239	1.000	1.000
580	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(7), ACO2(11), CS(1), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(8), MTHFD2(1)	7504146	55	39	54	22	16	15	5	8	11	0	0.605	1.000	1.000
581	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(8), BCL2(4), CASP3(2), CASP9(3), DAXX(11), FAS(3), FASLG(5), HSPB1(2), HSPB2(1), IL1A(2), MAPKAPK2(3), MAPKAPK3(5), TNF(3)	6646269	56	39	56	20	17	7	4	15	13	0	0.540	1.000	1.000
582	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(6), IARS(11), LARS(9), LARS2(10), PDHA1(1), PDHA2(11), PDHB(4)	5872001	52	39	51	21	8	7	10	16	11	0	0.831	1.000	1.000
583	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), FPGS(7), GCH1(1), GGH(2), SPR(2)	3816869	45	38	44	21	25	4	1	7	8	0	0.552	1.000	1.000
584	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(10), CCNA2(1), CCND1(2), CCNE1(5), CCNE2(3), CDK2(4), CDK4(2), CDKN1B(1), E2F1(4), E2F2(5), E2F4(2), PRB1(3)	4909590	42	38	42	16	6	12	7	9	8	0	0.561	1.000	1.000
585	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(11), CS(1), FH(4), IDH2(4), MDH1(3), OGDH(11), SDHA(11), SUCLA2(3)	5524992	48	37	44	19	16	8	3	5	16	0	0.773	1.000	1.000
586	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), PAK1(5), PDGFRA(13), PIK3R1(12), RAC1(1), WASL(5)	6574373	54	36	53	23	5	7	11	10	20	1	0.943	1.000	1.000
587	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(6), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), XYLT1(11)	2906658	47	36	44	25	25	3	9	8	2	0	0.896	1.000	1.000
588	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(6), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), XYLT1(11)	2906658	47	36	44	25	25	3	9	8	2	0	0.896	1.000	1.000
589	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(9), FARSA(6), FARSB(3), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(8), YARS2(2)	5102813	44	36	44	18	15	7	4	11	7	0	0.765	1.000	1.000
590	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(3), B3GALT2(8), B3GALT5(2), B3GNT5(11), FUT1(5), FUT2(2), FUT3(4), ST3GAL3(2), ST3GAL4(7)	4237363	44	36	41	19	19	5	2	5	13	0	0.888	1.000	1.000
591	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(6), CYP11A1(6), CYP11B2(8), CYP17A1(7), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2)	4055785	41	33	41	21	12	4	6	11	8	0	0.947	1.000	1.000
592	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(2), EHHADH(4), HADH(2), HADHA(5), HSD17B4(7), NTAN1(5), SIRT1(8), SIRT2(4), SIRT5(4), SIRT7(5), VNN2(4)	6946391	53	33	49	14	13	8	7	7	18	0	0.249	1.000	1.000
593	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(10), CKM(1), EIF4E(2), FBL(6), GPT(4), LDHA(7), LDHB(5), LDHC(1), MAPK14(2), NCL(7)	5260807	45	33	44	18	11	12	2	11	9	0	0.769	1.000	1.000
594	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(6), ACAT2(5), BDH1(7), HMGCS1(2), HMGCS2(4), OXCT1(10), OXCT2(6)	4217793	40	32	38	16	12	7	4	5	12	0	0.797	1.000	1.000
595	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), NFS1(1), PHPT1(2), THTPA(2), TPK1(5)	3760869	38	32	37	12	8	5	7	5	13	0	0.485	1.000	1.000
596	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), LTB4R(2), P2RY1(3), P2RY2(5), P2RY6(10)	3494679	37	32	36	21	23	2	1	5	6	0	0.858	1.000	1.000
597	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(9), CLOCK(8), CRY1(3), CRY2(7), CSNK1E(9), PER1(6)	4959498	42	31	40	14	16	6	3	5	12	0	0.634	1.000	1.000
598	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(3), ENO3(4), FARS2(9), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(8)	4872049	43	31	43	16	14	9	4	9	7	0	0.465	1.000	1.000
599	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(8), TAX1BP3(1), UBE2A(1), UBE2C(1), UBE2D3(1), UBE2E1(2), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(5), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(2), UBE2S(3), UBE3A(5)	6163233	42	31	42	13	18	6	4	6	8	0	0.180	1.000	1.000
600	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(8), AASDH(10), AASDHPPT(1), AASS(10), KARS(7)	4083810	36	30	36	11	7	6	8	7	8	0	0.453	1.000	1.000
601	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(11), CS(1), MDH1(3), ME1(1), PC(18), PDHA1(1), SLC25A1(3), SLC25A11(2)	5427701	40	30	39	20	15	6	6	7	6	0	0.888	1.000	1.000
602	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(7), GAD1(8), HDC(11), TH(7), TPH1(4)	3250156	37	30	37	17	10	4	4	7	12	0	0.888	1.000	1.000
603	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB10(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMB8(5), PSMB9(2)	5126308	46	30	46	14	15	4	10	8	9	0	0.371	1.000	1.000
604	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(4), FUT1(5), FUT2(2), FUT9(7), GCNT2(1), ST8SIA1(12)	3596976	31	28	29	16	11	2	3	11	4	0	0.875	1.000	1.000
605	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(5), CDC25B(6), CDKN1A(5), CHEK1(6), NEK1(6), WEE1(6)	4029715	34	28	34	11	7	6	4	7	10	0	0.717	1.000	1.000
606	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(8), NDUFA1(1), SDHA(11), SDHB(4), SDHC(2), SDHD(1), UQCRC1(3)	3879239	33	27	33	12	11	4	5	6	7	0	0.472	1.000	1.000
607	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), RAC1(1), WASF1(8), WASL(5)	4764757	36	25	36	19	8	5	4	6	13	0	0.972	1.000	1.000
608	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	4	GOT1(3), GOT2(2), TAT(5), TYR(15)	2171800	25	24	23	13	6	4	3	9	3	0	0.917	1.000	1.000
609	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHB(5), LDHC(1), MPST(3)	4012305	30	23	30	13	10	8	5	2	5	0	0.732	1.000	1.000
610	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(6), EPHX2(3), HSD3B7(7), RDH11(1), RDH12(3), RDH13(7)	2812442	27	23	26	11	10	5	3	4	5	0	0.674	1.000	1.000
611	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(5), FUT2(2), FUT3(4), FUT5(3), FUT6(6), ST3GAL3(2)	2988972	22	19	22	15	12	3	2	2	3	0	0.956	1.000	1.000
612	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(6), RDH5(3)	2289730	15	15	15	10	4	1	1	5	4	0	0.982	1.000	1.000
613	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(3), RAB27A(4), RAB3A(1), RAB4A(1), RAB5A(3)	2489670	16	12	16	16	6	1	4	2	3	0	0.991	1.000	1.000
614	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(5), PGLYRP2(6)	1060870	11	10	11	6	8	1	2	0	0	0	0.806	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		299280	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
