rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(15)	619862	15	15	13	1	6	1	2	1	5	0	0.0554	0.000522	0.321
2	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(16), FMOD(14), KERA(7), LUM(11)	3111171	50	43	49	4	16	4	5	20	5	0	0.000950	0.0517	1.000
3	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(7), GRIA2(34), JUND(2), PPP1R1B(3)	3217314	49	41	49	7	8	10	7	17	7	0	0.0105	0.416	1.000
4	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(9), GSTZ1(2), HGD(8)	1923828	19	19	17	3	5	1	3	4	6	0	0.251	0.556	1.000
5	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(5), LIPT1(5)	1307022	10	10	9	1	2	3	1	0	3	1	0.182	0.583	1.000
6	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(14), AOC3(18), CES1(21), ESD(1)	5206909	54	48	51	6	16	4	4	13	17	0	0.0182	0.794	1.000
7	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(8), TPI1(3)	1411081	11	11	11	2	5	2	1	2	1	0	0.253	0.835	1.000
8	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(3), TGDS(7), UGDH(11), UXS1(9)	3359335	32	29	31	4	9	3	6	8	6	0	0.0352	0.905	1.000
9	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(5), SRP19(3), SRP54(11), SRP68(8), SRP72(16), SRP9(2), SRPR(18)	6486893	67	55	64	6	16	9	12	11	19	0	0.000999	0.940	1.000
10	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(9), CCL2(1), CSF1(6), IL6(1), LDLR(15), LPL(11)	4576270	43	39	39	7	11	5	4	6	17	0	0.0268	0.953	1.000
11	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(7), CDC34(2), CDK2(5), CUL1(28), E2F1(6), RB1(22), TFDP1(6)	5759570	76	62	75	13	12	8	14	14	28	0	0.0119	0.963	1.000
12	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(3)	978854	3	3	3	1	0	0	2	1	0	0	0.686	0.972	1.000
13	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(3), TGDS(7), UGDH(11), UGP2(9), UXS1(9)	4259646	41	34	39	5	11	3	6	10	11	0	0.0289	0.979	1.000
14	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(5), FDPS(14), IDI1(3), SQLE(10)	2790299	32	25	31	5	7	4	4	8	9	0	0.0756	0.983	1.000
15	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(8), ALDOA(1), ALDOB(11), ALDOC(11), TPI1(3)	3349434	34	33	34	6	8	8	4	10	4	0	0.0612	0.987	1.000
16	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(4), CCR3(14), HLA-DRA(7), HLA-DRB1(2), IL3(3)	2621576	31	25	29	7	11	4	3	7	6	0	0.150	0.990	1.000
17	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(8), ACADM(7), ACADS(6), ACAT1(9), ECHS1(3), HADHA(7)	4687363	40	34	37	5	8	7	5	8	12	0	0.0272	0.991	1.000
18	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(7), CDK2(5), CDKN1B(1), CKS1B(2), CUL1(28), E2F1(6), NEDD8(2), RB1(22), RBX1(1), SKP2(6), TFDP1(6), UBE2M(2)	7430168	88	68	87	14	10	12	16	16	34	0	0.00567	0.994	1.000
19	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(8), CHRNA1(11), SNAP25(3), STX1A(6), VAMP2(1)	2793694	29	27	28	6	12	1	3	8	5	0	0.216	0.995	1.000
20	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(5), FDPS(14), GGPS1(4), IDI1(3), IDI2(4), SQLE(10)	3720062	40	29	39	6	9	5	4	10	12	0	0.0527	0.997	1.000
21	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(6), BCKDK(8), CBS(9), CTH(3), MUT(10)	4197717	36	34	35	6	7	4	4	5	16	0	0.119	0.998	1.000
22	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(14), CD4(11), HLA-DRA(7), HLA-DRB1(2), IL1B(7), IL4(4), IL5RA(12), IL6(1)	4590639	59	48	52	14	12	7	7	13	20	0	0.191	0.999	1.000
23	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(9), ACAT2(6), OXCT1(10)	2928835	25	24	23	7	3	8	2	3	9	0	0.691	0.999	1.000
24	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(8), IFNG(3), IL12A(3), IL12B(3), IL18(1)	2565850	18	17	18	5	2	3	2	9	2	0	0.608	0.999	1.000
25	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(40), ABCB11(17), ABCB4(33), ABCC1(17), ABCC3(16), GSTP1(2)	12426372	125	95	116	16	26	16	15	28	40	0	9.51e-05	0.999	1.000
26	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(9), SUCLA2(3)	1846978	12	12	12	3	6	1	1	1	3	0	0.437	0.999	1.000
27	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(5), LPL(11), NR3C1(10), PPARG(6), RETN(2), RXRA(13), TNF(3)	4959007	50	46	46	12	14	4	6	12	14	0	0.235	1.000	1.000
28	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), HLCS(9), SPCS1(2), SPCS3(3)	2612688	19	17	19	6	4	1	1	11	2	0	0.605	1.000	1.000
29	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(13), CCNE1(7), CDC34(2), CDK2(5), CUL1(28), E2F1(6), RB1(22), SKP2(6), TFDP1(6)	7443450	95	77	94	21	13	13	18	19	32	0	0.0371	1.000	1.000
30	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	5	ADAM17(12), NRG2(11), NRG3(32), PRKCA(9), PSEN1(7)	5478618	71	59	69	19	19	8	12	16	16	0	0.211	1.000	1.000
31	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(8), SLPI(2)	1462374	10	9	10	5	6	1	0	1	2	0	0.740	1.000	1.000
32	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(71), CDC25A(8), CDC25B(8), CDC25C(11), CDK2(5), CDK4(2), CHEK1(7), MYT1(26), RB1(22), WEE1(7), YWHAH(3)	14455566	170	112	161	28	29	24	17	44	52	4	0.00393	1.000	1.000
33	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(9), ACAT2(6), ACYP1(2), ACYP2(3), ECHS1(3), EHHADH(5), GCDH(8), HADHA(7), SDHB(4), SDS(5)	6753528	52	40	47	9	8	12	8	7	17	0	0.0519	1.000	1.000
34	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(71), CDC25A(8), CDC25B(8), CDC25C(11), CHEK1(7), MYT1(26), WEE1(7), YWHAH(3)	11857508	141	96	133	26	29	20	12	39	37	4	0.0166	1.000	1.000
35	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(11), ARHGAP5(34), ARHGDIB(1), CASP1(8), CASP10(8), CASP3(2), CASP9(4), GZMB(2), JUN(6), PRF1(17)	10055870	93	69	88	14	20	13	11	23	23	3	0.0107	1.000	1.000
36	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(2), GGT1(9), SHMT1(4), SHMT2(13)	3626302	28	25	25	9	8	3	3	3	11	0	0.451	1.000	1.000
37	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(3), ASL(8), CPS1(35), GLS(13), GLUD1(5), GOT1(3)	6717965	67	55	65	13	17	7	9	25	9	0	0.0444	1.000	1.000
38	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(6), IL1B(7), MST1R(20), TNF(3)	5616470	37	30	36	5	4	8	0	10	15	0	0.0425	1.000	1.000
39	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(4), CDC25A(8), CDC25B(8), CDC25C(11), CSK(10), GRB2(4), PRKCA(9), PTPRA(19), SRC(5)	7968717	78	59	74	14	23	8	9	16	21	1	0.0170	1.000	1.000
40	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(7), PIK3R1(17), PLCB1(24), PLCG1(27), PRKCA(9), VAV1(21)	9206495	105	77	99	18	30	12	12	20	30	1	0.00654	1.000	1.000
41	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(8), CYP2C9(5)	1748393	13	11	13	5	5	1	1	5	1	0	0.830	1.000	1.000
42	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), MIOX(8), UGDH(11)	7276367	87	61	75	19	19	9	11	20	28	0	0.122	1.000	1.000
43	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(47), GNA12(2), PRKACB(6), PRKACG(9), PRKAG1(6), PRKAR2A(3), PRKAR2B(12)	8621689	85	68	80	16	14	15	11	19	24	2	0.0499	1.000	1.000
44	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(7), FOS(2), FYN(10), JUN(6), MAPK14(3), THBS1(19)	6330837	49	42	46	10	10	7	10	12	10	0	0.104	1.000	1.000
45	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(6), GBA(14), GGT1(9), SHMT1(4), SHMT2(13)	4796538	46	39	43	10	14	4	7	7	14	0	0.100	1.000	1.000
46	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(2), CD3E(3), IFNG(3), IL2RA(3), IL4(4), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TGFBR3(12), TOB1(3), TOB2(7)	8092646	71	64	69	17	15	6	12	21	17	0	0.234	1.000	1.000
47	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(6), ECHS1(3), EHHADH(5), HADHA(7), SDS(5)	4186499	26	23	25	7	6	4	3	7	6	0	0.268	1.000	1.000
48	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(4), CASP3(2), CFL1(2), CFLAR(3), PDE6D(1)	2276706	12	11	12	6	2	4	1	3	2	0	0.802	1.000	1.000
49	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(7)	2258060	12	12	12	9	4	2	1	3	2	0	0.955	1.000	1.000
50	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAA2(13), ACAT1(9), ACAT2(6), ECHS1(3), EHHADH(5), HADHA(7), HADHB(6), SDS(5)	7227484	57	42	54	10	7	13	11	7	19	0	0.0285	1.000	1.000
51	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(8), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT5(5), FUT8(11), ST3GAL1(7), ST3GAL2(11), ST3GAL3(3), ST3GAL4(8)	6751311	72	66	71	16	25	11	8	18	10	0	0.0849	1.000	1.000
52	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	ARF1(6), CCND1(3), CDK2(5), CDK4(2), CDKN1A(7), CDKN1B(1), CFL1(2), E2F1(6), MDM2(10), NXT1(4), PRB1(5)	5384966	51	39	47	10	13	10	5	8	14	1	0.0852	1.000	1.000
53	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(9), AASDHPPT(1), AASS(13), KARS(9)	4067313	32	26	31	9	7	7	5	8	5	0	0.405	1.000	1.000
54	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(43), C5(15), C6(19), C7(11), C8A(13), C9(10)	10855957	111	79	105	26	26	18	14	32	21	0	0.0580	1.000	1.000
55	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(11), BAD(4), BAK1(5), BAX(3), BCL10(3), BCL2(4), BCL2L1(2), BCL2L11(7), BID(3), CASP9(4), CES1(21)	9460139	67	51	66	12	22	14	6	15	10	0	0.0138	1.000	1.000
56	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(4), CCNH(3), CDC25A(8), CDC25B(8), CDC25C(11), MNAT1(4), SHH(6), XPO1(17)	7450212	61	45	55	14	14	12	4	15	15	1	0.199	1.000	1.000
57	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(11), F13A1(20), F2(15), F2R(10), FGA(16), FGB(9), FGG(6), PLAT(8), PLG(21), SERPINB2(11), SERPINE1(3)	11547958	130	93	124	29	37	12	16	36	29	0	0.0352	1.000	1.000
58	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(6), COASY(5), DPYD(25), DPYS(12), ENPP1(12), ENPP3(16), PANK1(14), PANK2(10), PANK3(6), PANK4(9), PPCS(2), UPB1(6)	12031110	123	90	118	23	20	18	18	37	30	0	0.00352	1.000	1.000
59	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7)	6802335	85	60	74	23	21	8	8	18	30	0	0.343	1.000	1.000
60	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7)	6802335	85	60	74	23	21	8	8	18	30	0	0.343	1.000	1.000
61	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(8), F13B(20), HSD17B1(5), HSD17B2(3), HSD17B3(2), HSD17B4(11), HSD17B7(5), HSD3B1(6), HSD3B2(5)	6941058	65	49	64	17	9	12	11	21	12	0	0.187	1.000	1.000
62	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(5), RANBP1(1), RANBP2(42), RANGAP1(15)	7305308	63	48	62	17	8	12	14	15	12	2	0.214	1.000	1.000
63	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(40), AKT1(7), ATM(71), BAX(3), CDKN1A(7), CPB2(11), CSNK1A1(7), CSNK1D(5), FHL2(2), HIC1(11), HIF1A(10), HSPA1A(4), IGFBP3(7), MAPK8(7), MDM2(10), NFKBIB(8), NQO1(4)	17178424	214	139	201	38	45	40	20	51	54	4	0.000216	1.000	1.000
64	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(4), FOS(2), JUN(6), KEAP1(17), MAFF(1), MAPK1(4), MAPK14(3), MAPK8(7), PRKCA(9)	6749042	53	45	52	13	15	10	8	9	11	0	0.0605	1.000	1.000
65	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(11), CD80(6), HLA-DRA(7), HLA-DRB1(2), IL10(4), IL4(4)	3410663	36	35	30	11	11	2	3	9	11	0	0.659	1.000	1.000
66	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(26), GNAS(54), GNB1(2), GNGT1(4), PRKACA(9), PRKAR1A(4)	5712533	99	76	91	26	45	7	3	24	19	1	0.286	1.000	1.000
67	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(5), CREBBP(59), DFFA(5), DFFB(5), GZMA(5), GZMB(2), HMGB2(4), PRF1(17), SET(10)	9089412	113	84	107	29	30	12	14	30	27	0	0.111	1.000	1.000
68	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(13), GLS2(8), GLUD1(5), GLUD2(17)	3894596	43	33	42	11	9	4	6	15	9	0	0.328	1.000	1.000
69	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	17	IL18(1), ITGB1(12), KLRC1(4), KLRC2(2), KLRC3(10), KLRC4(1), KLRD1(5), LAT(3), MAP2K1(9), MAPK3(3), PAK1(7), PIK3R1(17), PTK2B(20), PTPN6(6), RAC1(2), SYK(11), VAV1(21)	13401534	134	100	125	27	29	17	13	35	39	1	0.0173	1.000	1.000
70	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(6), DAB1(17), FYN(10), LRP8(8), RELN(69), VLDLR(7)	12019659	120	86	116	25	26	24	17	35	18	0	0.00439	1.000	1.000
71	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(8), GNAS(54), GNB1(2), GNGT1(4), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9)	8337604	121	92	110	27	55	11	4	22	28	1	0.0607	1.000	1.000
72	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(9), ST3GAL1(7), ST3GAL2(11), ST3GAL4(8), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(3), ST8SIA1(12)	4791164	54	48	52	17	22	2	9	14	7	0	0.379	1.000	1.000
73	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(13), ECHS1(3), HADH(3), HADHA(7), HADHB(6), HSD17B4(11), MECR(4), PPT1(6), PPT2(4)	7321608	57	40	56	10	10	11	12	8	16	0	0.00997	1.000	1.000
74	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(6), CDO1(3), CSAD(9), GAD1(11), GAD2(17), GGT1(9)	4980506	55	45	53	18	17	8	5	10	15	0	0.344	1.000	1.000
75	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(18), GBA(14), LPO(14), MPO(12), PRDX6(5), TPO(35)	7217196	98	83	95	25	31	13	9	28	16	1	0.113	1.000	1.000
76	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(28), GABRA2(18), GABRA3(12), GABRA4(12), GABRA5(12), GABRA6(18), PRKCE(16)	6817756	116	84	113	32	24	9	24	45	14	0	0.156	1.000	1.000
77	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(19), APOBEC1(8), APOBEC2(5), APOBEC3B(5), APOBEC3C(1), APOBEC3F(3), APOBEC3G(5), APOBEC4(4)	6312982	50	38	49	10	14	9	6	14	7	0	0.0880	1.000	1.000
78	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(27), PRKCA(9), PTK2B(20)	5754319	61	50	57	14	28	7	3	8	15	0	0.0594	1.000	1.000
79	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(8), HLA-DRA(7), HLA-DRB1(2), IFNG(3), IFNGR1(11), IFNGR2(2), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL18(1), IL18R1(7), IL2RA(3), IL4(4), IL4R(10)	10892142	90	65	90	23	18	11	13	26	22	0	0.176	1.000	1.000
80	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(9), ACO2(12), FH(4), IDH1(5), IDH2(8), MDH1(5), MDH2(2), SDHB(4), SUCLA2(3)	7679196	52	41	51	11	16	11	4	9	12	0	0.105	1.000	1.000
81	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(71), ATR(33), CDC25C(11), CHEK1(7), CHEK2(13), YWHAH(3)	13020945	138	92	129	23	24	13	16	36	45	4	0.0648	1.000	1.000
82	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(2), CD3E(3), CD80(6), CD86(8), CTLA4(4), GRB2(4), HLA-DRA(7), HLA-DRB1(2), ICOS(4), ITK(12), LCK(5), PIK3R1(17), PTPN11(10)	9117481	84	71	79	19	20	5	11	25	22	1	0.234	1.000	1.000
83	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(4), IFNG(3), IFNGR1(11), JAK1(22), JAK2(14), PLA2G2A(2), PTPRU(33), REG1A(5), STAT1(14)	9878865	108	79	104	26	30	17	10	17	31	3	0.0916	1.000	1.000
84	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(8), ASPH(10), COPS5(6), CREB1(4), EDN1(4), EP300(39), EPO(3), HIF1A(10), JUN(6), LDHA(7), NOS3(20), P4HB(5), VHL(2)	14641881	124	89	116	23	25	21	17	28	33	0	0.00836	1.000	1.000
85	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(13), ACO1(9), ACO2(12), ACSS1(18), ACSS2(20), FH(4), IDH1(5), IDH2(8), MDH1(5), MDH2(2), SUCLA2(3)	11447763	99	68	97	19	23	25	7	21	23	0	0.00846	1.000	1.000
86	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(8), CSF1(6), FCGR3A(6), IL1B(7), IL6R(4), SELL(7), SPN(5), TGFB1(3), TGFB2(10), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TNFRSF8(12), TNFSF8(4)	11518027	99	73	95	28	25	10	9	26	28	1	0.189	1.000	1.000
87	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(15), PARK2(16), SNCA(1), SNCAIP(20), UBE2E2(1), UBE2F(4), UBE2G2(3), UBE2L3(1), UBE2L6(2)	5472712	63	53	61	22	18	10	8	16	11	0	0.384	1.000	1.000
88	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11)	4856023	34	29	33	12	6	2	6	13	7	0	0.619	1.000	1.000
89	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(5), CD34(6), CD3E(3), CD4(11), CD58(8), CD8A(4), CSF3(3), IL3(3), IL6(1), KITLG(6)	5353744	50	42	44	17	6	7	8	10	19	0	0.668	1.000	1.000
90	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(8), GAD1(11), HDC(13), PNMT(11), TH(10), TPH1(6)	5185045	59	50	58	20	20	8	4	13	14	0	0.480	1.000	1.000
91	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(18), PDXK(4), PDXP(5), PNPO(4), PSAT1(10)	4151450	41	35	41	15	5	7	6	14	7	2	0.606	1.000	1.000
92	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(9), CYSLTR2(1), GPR161(18), GPR171(2), GPR18(4), GPR34(1), GPR39(11), GPR45(18), GPR65(1), GPR68(5), GPR75(6)	8330801	76	60	68	22	31	5	12	12	16	0	0.229	1.000	1.000
93	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(6), ANKRD1(6), ATF3(2), CYR61(2), DUSP14(3), EIF4E(2), EIF4EBP1(5), HBEGF(2), IFNG(3), IFRD1(10), IL18(1), IL1A(2), IL1R1(5), JUND(2), MYOG(4), NR4A3(8), WDR1(5)	9210517	68	50	62	16	23	6	5	12	22	0	0.123	1.000	1.000
94	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(9), IFNB1(4), JAK1(22), PTPRU(33), REG1A(5), STAT1(14), STAT2(10), TYK2(15)	10790986	112	80	108	25	37	12	10	18	33	2	0.0458	1.000	1.000
95	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(5), ALAS2(16), CPOX(5), FECH(8), HMBS(4), PPOX(10), UROD(3), UROS(6)	6465947	62	54	61	14	15	13	4	16	14	0	0.151	1.000	1.000
96	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), SHMT1(4)	12091683	111	82	107	25	26	15	17	26	27	0	0.0630	1.000	1.000
97	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), SHMT1(4)	12091683	111	82	107	25	26	15	17	26	27	0	0.0630	1.000	1.000
98	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), SHMT1(4)	12091683	111	82	107	25	26	15	17	26	27	0	0.0630	1.000	1.000
99	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(3), CALM3(2), CCL2(1), CCR5(5), CXCR4(1), FOS(2), GNAQ(4), JUN(6), MAPK14(3), MAPK8(7), PLCG1(27), PRKCA(9), PTK2B(20), SYT1(8)	11859953	100	80	95	23	35	13	10	19	23	0	0.0225	1.000	1.000
100	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(10), GABRA1(28), GABRA2(18), GABRA3(12), GABRA4(12), GABRA5(12), GABRA6(18), GPHN(16), NSF(2), SRC(5), UBQLN1(7)	10363622	140	97	136	35	29	13	30	50	18	0	0.0680	1.000	1.000
101	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	12	APC(68), AXIN1(17), CREBBP(59), DVL1(8), EP300(39), FZD1(15), GSK3B(9), HDAC1(10), LDB1(5), LEF1(5), PITX2(6), TRRAP(77)	26497467	318	176	299	62	93	29	37	64	89	6	2.49e-05	1.000	1.000
102	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(3), IFNGR1(11), IFNGR2(2), JAK1(22), JAK2(14), STAT1(14)	7075360	66	50	63	20	11	11	8	13	20	3	0.661	1.000	1.000
103	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(6), CYP2A13(15), CYP2A6(8), CYP2A7(9), NAT1(2), NAT2(6), XDH(32)	6915994	78	68	76	23	16	13	12	27	10	0	0.264	1.000	1.000
104	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(10), CHPT1(4), HEMK1(2), LCMT1(2), LCMT2(11), METTL2B(1), METTL6(5), PCYT1A(11), PCYT1B(9), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), WBSCR22(5)	12080911	107	71	101	21	23	19	14	23	27	1	0.0114	1.000	1.000
105	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(8), ACADM(7), ACADS(6), ACADVL(5), ACSL1(6), ACSL3(10), ACSL4(7), CPT1A(16), CPT2(8), EHHADH(5), HADHA(7), PECR(1), SCP2(6), SLC25A20(4)	14452312	96	70	93	18	22	10	13	22	29	0	0.0120	1.000	1.000
106	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(2), CASP7(5), DFFA(5), DFFB(5), ENDOG(2), GZMB(2), HMGB1(4), HMGB2(4), TOP2A(22), TOP2B(19)	8217118	70	55	60	16	10	11	8	24	17	0	0.427	1.000	1.000
107	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(9), ACP2(6), ACP5(4), ACPP(8), ACPT(6), ENPP1(12), ENPP3(16), FLAD1(6), RFK(3), TYR(18)	8387985	88	69	80	21	12	15	15	24	22	0	0.167	1.000	1.000
108	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF3(3), EPO(3), FLT3(21), IGF1(3), IL11(3), IL1A(2), IL3(3), IL6(1), KITLG(6), TGFB1(3), TGFB2(10), TGFB3(11)	7186976	70	56	67	22	17	10	8	17	18	0	0.419	1.000	1.000
109	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), FDXR(12), SHMT1(4)	12894597	123	86	119	27	31	17	20	27	28	0	0.0308	1.000	1.000
110	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(9), IFNAR2(4), IFNB1(4), JAK1(22), STAT1(14), STAT2(10), TYK2(15)	9381526	79	58	76	19	20	8	11	16	22	2	0.213	1.000	1.000
111	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(8), ARG1(3), GLS(13), GLUD1(5), OAT(6), PRODH(1)	4849047	36	30	35	12	7	4	5	12	8	0	0.507	1.000	1.000
112	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(11), BAK1(5), BAX(3), BCL2(4), BCL2L1(2), BID(3), BIK(1), BIRC2(8), BIRC3(12), CASP3(2), CASP6(2), CASP7(5), CASP9(4), DFFA(5), DFFB(5), DIABLO(1), ENDOG(2)	10697658	75	56	73	16	18	13	10	17	17	0	0.0633	1.000	1.000
113	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(7), BLVRB(1), HMOX1(8), IL10(4), IL10RA(8), IL10RB(3), IL1A(2), IL6(1), JAK1(22), STAT1(14), STAT3(9), STAT5A(13), TNF(3)	10508719	95	71	90	25	18	10	9	28	28	2	0.294	1.000	1.000
114	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(4), MTMR1(8), MTMR2(10), MTMR6(14), NFS1(1), PHPT1(2), THTPA(3), TPK1(5)	5500822	47	38	45	14	8	7	8	7	17	0	0.419	1.000	1.000
115	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(7), BCAR1(16), CDKN1B(1), GRB2(4), ILK(11), ITGB1(12), MAPK1(4), MAPK3(3), PDK2(2), PDPK1(1), PIK3R1(17), PTK2(12), SHC1(7), SOS1(12)	14047295	109	83	104	23	27	10	15	25	31	1	0.0569	1.000	1.000
116	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(5), LDLR(15), NR0B2(4), NR1H3(5), NR1H4(8), RXRA(13)	4684048	50	39	49	17	22	4	4	8	12	0	0.344	1.000	1.000
117	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), ECHS1(3), EHHADH(5), HADHA(7), SDS(5)	10410673	105	67	93	29	25	12	10	23	35	0	0.255	1.000	1.000
118	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(5), ALAS1(5), ALAS2(16), CPO(8), FECH(8), GATA1(4), HBA2(1), HBB(4), HMBS(4), UROD(3), UROS(6)	6809095	64	55	63	18	15	14	8	14	13	0	0.243	1.000	1.000
119	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(8), GNAQ(4), GNB1(2), GNGT1(4), HTR2C(11), PLCB1(24), TUB(10)	6145324	63	50	61	18	16	8	7	17	15	0	0.382	1.000	1.000
120	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	APC(68), CREBBP(59), EP300(39), MAP2K1(9), MAP3K7(14), MAPK3(3), SKIL(9), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10)	19405163	235	150	216	48	49	23	29	54	76	4	0.0148	1.000	1.000
121	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(5), BIRC3(12), FADD(4), RIPK1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF2(5)	6178095	46	41	45	16	11	7	4	7	16	1	0.615	1.000	1.000
122	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(15), MBTPS1(16), MBTPS2(12), SCAP(18), SREBF1(18), SREBF2(17)	10175612	98	68	95	25	29	8	11	23	27	0	0.110	1.000	1.000
123	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(59), EP300(39), LPL(11), NCOA1(27), NCOA2(33), PPARG(6), RXRA(13)	15810987	188	113	178	39	50	26	23	46	43	0	0.00225	1.000	1.000
124	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BET1L(1), BNIP1(8), GOSR1(3), GOSR2(4), SNAP25(3), SNAP29(2), STX10(5), STX11(8), STX12(4), STX16(13), STX17(4), STX18(3), STX19(6), STX2(7), STX3(2), STX4(4), STX5(2), STX6(8), STX7(4), STX8(4), TSNARE1(8), USE1(5), VAMP1(1), VAMP2(1), VAMP4(3), VAMP5(2), VAMP7(2), VAMP8(1), VTI1A(6), VTI1B(3), YKT6(5)	14474448	134	92	130	26	39	22	16	28	29	0	0.00576	1.000	1.000
125	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(5), BRAF(22), CAMP(3), CREB1(4), CREB5(9), MAPK1(4), RAF1(11), SNX13(13), SRC(5), TERF2IP(6)	9749378	86	66	79	21	19	14	9	22	22	0	0.196	1.000	1.000
126	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(10), MAX(4), MYC(6), SP1(6), SP3(7), WT1(9)	5330723	42	36	40	14	12	8	4	9	9	0	0.366	1.000	1.000
127	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(6), ECHS1(3), EHHADH(5), HADH(3), HADHA(7), HSD17B4(11), NTAN1(7), SIRT1(13), SIRT2(4), SIRT5(5), SIRT7(6), VNN2(4)	10221351	74	51	69	18	17	13	9	14	21	0	0.113	1.000	1.000
128	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), ESCO1(13), ESCO2(11), NAT6(4), PNPLA3(4), SH3GLB1(5)	14014545	60	49	58	9	14	4	6	11	25	0	0.0736	1.000	1.000
129	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	186	ACTB(10), ACTG1(2), ACTN1(8), ACTN2(34), ACTN4(20), AKT1(7), AKT2(11), AKT3(10), ARHGAP5(34), BAD(4), BCAR1(16), BCL2(4), BIRC2(8), BIRC3(12), BRAF(22), CAPN2(11), CAV1(6), CAV2(1), CAV3(2), CCND1(3), CCND2(2), CCND3(1), CDC42(3), CHAD(7), COL11A1(67), COL11A2(26), COL1A1(21), COL1A2(39), COL2A1(26), COL3A1(23), COL4A1(35), COL4A2(24), COL4A4(25), COL4A6(15), COL5A1(39), COL5A2(25), COL5A3(22), COL6A1(19), COL6A2(33), COL6A3(67), COL6A6(53), COMP(8), CRK(2), CRKL(2), DIAPH1(16), DOCK1(29), EGF(15), EGFR(24), ELK1(6), FARP2(9), FIGF(5), FLNA(31), FLNB(37), FLNC(48), FLT1(26), FN1(40), FYN(10), GRB2(4), GSK3B(9), HRAS(2), IBSP(9), IGF1(3), IGF1R(24), ILK(11), ITGA1(10), ITGA10(19), ITGA11(18), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGAV(23), ITGB1(12), ITGB3(8), ITGB4(29), ITGB5(10), ITGB6(9), ITGB7(7), ITGB8(18), JUN(6), KDR(22), LAMA1(85), LAMA2(51), LAMA3(37), LAMA4(33), LAMA5(58), LAMB1(22), LAMB2(30), LAMB3(22), LAMB4(33), LAMC1(29), LAMC2(14), LAMC3(25), MAP2K1(9), MAPK1(4), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(7), MET(14), MYL2(9), MYL7(5), MYL9(3), MYLK(31), MYLK2(9), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PARVA(4), PARVB(6), PARVG(6), PDGFA(4), PDGFB(8), PDGFC(11), PDGFD(11), PDGFRA(17), PDGFRB(16), PDPK1(1), PGF(4), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PIP5K1C(15), PPP1CA(3), PPP1CB(1), PPP1CC(4), PPP1R12A(4), PRKCA(9), PRKCG(19), PTK2(12), PXN(9), RAC1(2), RAC2(2), RAC3(4), RAF1(11), RAP1A(4), RAP1B(6), RAPGEF1(15), RELN(69), ROCK1(22), ROCK2(20), SHC1(7), SHC2(3), SHC3(12), SHC4(11), SOS1(12), SOS2(19), SPP1(4), SRC(5), THBS1(19), THBS2(24), THBS3(13), THBS4(18), TLN1(35), TLN2(43), TNC(35), TNN(38), TNR(36), TNXB(82), VASP(2), VAV1(21), VAV2(14), VAV3(16), VCL(19), VEGFB(2), VEGFC(17), VTN(10), VWF(47), ZYX(8)	313166342	3135	499	3022	1020	964	427	331	747	641	25	0.00250	1.000	1.000
130	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	232	ADCYAP1R1(10), ADORA1(7), ADORA2A(7), ADORA2B(4), ADORA3(9), ADRA1A(26), ADRA1B(6), ADRA2A(12), ADRA2B(11), ADRA2C(6), ADRB1(10), ADRB2(9), ADRB3(6), AGTR1(1), AGTR2(6), AVPR1A(20), AVPR1B(3), AVPR2(12), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(13), C5AR1(7), CALCR(6), CALCRL(11), CCKAR(8), CCKBR(19), CGA(1), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), CNR1(16), CNR2(4), CRHR1(14), CRHR2(4), CTSG(4), CYSLTR1(9), CYSLTR2(1), DRD1(7), DRD2(14), DRD3(9), DRD4(6), DRD5(13), EDNRA(5), F2(15), F2R(10), F2RL1(2), F2RL2(5), F2RL3(6), FPR1(9), FSHB(1), FSHR(30), GABBR1(20), GABBR2(18), GABRA1(28), GABRA2(18), GABRA3(12), GABRA4(12), GABRA5(12), GABRA6(18), GABRB1(17), GABRB2(7), GABRB3(17), GABRD(8), GABRE(10), GABRG1(16), GABRG2(20), GABRG3(11), GABRP(7), GABRQ(12), GABRR1(7), GABRR2(8), GALR1(8), GALR2(14), GALR3(5), GH1(3), GH2(4), GHR(11), GHRHR(6), GHSR(10), GIPR(7), GLP1R(2), GLP2R(12), GLRA1(8), GLRA2(6), GLRA3(8), GLRB(16), GNRHR(5), GPR156(12), GPR35(5), GPR50(12), GPR63(6), GPR83(9), GRIA1(31), GRIA2(34), GRIA3(16), GRIA4(23), GRID1(30), GRID2(30), GRIK1(16), GRIK2(21), GRIK3(26), GRIK4(24), GRIK5(20), GRIN1(11), GRIN2A(23), GRIN2B(31), GRIN2C(13), GRIN2D(12), GRIN3A(24), GRIN3B(10), GRM1(52), GRM2(30), GRM3(31), GRM4(22), GRM6(21), GRM7(30), GRM8(38), GRPR(7), GZMA(5), HCRTR1(6), HCRTR2(14), HRH1(7), HRH2(9), HRH3(8), HRH4(10), HTR1A(18), HTR1B(11), HTR1D(9), HTR1E(18), HTR1F(10), HTR2A(12), HTR2B(5), HTR2C(11), HTR4(5), HTR5A(14), HTR6(7), HTR7(17), LEP(3), LEPR(18), LHB(3), LTB4R(2), LTB4R2(6), MAS1(4), MC1R(8), MC2R(4), MC3R(12), MC4R(11), MC5R(6), MCHR1(10), MCHR2(9), MLNR(5), MTNR1A(5), MTNR1B(10), NMBR(3), NMUR1(7), NMUR2(7), NPBWR1(25), NPBWR2(14), NPFFR1(3), NPFFR2(14), NPY1R(6), NPY2R(8), NPY5R(5), NR3C1(10), NTSR1(11), NTSR2(7), OPRD1(5), OPRK1(19), OPRL1(11), OPRM1(9), OXTR(9), P2RX1(5), P2RX2(8), P2RX3(7), P2RX4(9), P2RX5(7), P2RX7(4), P2RY1(5), P2RY10(14), P2RY11(5), P2RY13(7), P2RY14(6), P2RY2(5), P2RY6(12), P2RY8(9), PARD3(24), PRL(3), PRLHR(10), PRLR(8), PRSS1(6), PRSS3(4), PTAFR(4), PTGDR(8), PTGER2(8), PTGER3(9), PTGER4(15), PTGFR(6), PTGIR(2), PTH2R(13), RXFP1(14), RXFP2(18), SCTR(5), SSTR1(12), SSTR2(4), SSTR3(11), SSTR4(18), SSTR5(4), TAAR1(6), TAAR2(5), TAAR5(7), TAAR6(9), TAAR8(1), TACR1(4), TACR2(2), TACR3(18), TBXA2R(11), THRA(13), THRB(5), TRHR(7), TRPV1(11), TSHB(5), TSHR(15), TSPO(2), UTS2R(4), VIPR1(3), VIPR2(5)	185449515	2488	479	2393	843	822	305	311	688	358	4	0.000655	1.000	1.000
131	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	163	ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY7(23), ADCY8(48), ADCY9(23), ADORA2A(7), ADORA2B(4), ADRA1A(26), ADRA1B(6), ADRA1D(9), ADRB1(10), ADRB2(9), ADRB3(6), AGTR1(1), ATP2A1(16), ATP2A2(9), ATP2A3(14), ATP2B1(21), ATP2B2(27), ATP2B3(26), ATP2B4(23), AVPR1A(20), AVPR1B(3), BDKRB1(4), BDKRB2(3), BST1(4), CACNA1A(47), CACNA1B(38), CACNA1C(58), CACNA1D(50), CACNA1E(68), CACNA1F(21), CACNA1G(34), CACNA1H(50), CACNA1I(34), CACNA1S(31), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), CCKAR(8), CCKBR(19), CD38(7), CHRM1(8), CHRM2(27), CHRM3(17), CHRM5(5), CHRNA7(7), CYSLTR1(9), CYSLTR2(1), DRD1(7), EDNRA(5), EGFR(24), ERBB3(49), F2R(10), GNA11(6), GNA14(6), GNA15(6), GNAL(5), GNAQ(4), GNAS(54), GRIN1(11), GRIN2A(23), GRIN2C(13), GRIN2D(12), GRM1(52), GRPR(7), HRH1(7), HRH2(9), HTR2A(12), HTR2B(5), HTR2C(11), HTR4(5), HTR5A(14), HTR6(7), HTR7(17), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), LTB4R2(6), MYLK(31), MYLK2(9), NOS1(45), NOS3(20), NTSR1(11), OXTR(9), P2RX1(5), P2RX2(8), P2RX3(7), P2RX4(9), P2RX5(7), P2RX7(4), PDE1A(10), PDE1B(8), PDE1C(17), PDGFRA(17), PDGFRB(16), PHKA1(15), PHKA2(18), PHKB(11), PHKG1(4), PHKG2(13), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCD3(11), PLCD4(8), PLCE1(27), PLCG1(27), PLCG2(22), PLCZ1(14), PPID(6), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), PTAFR(4), PTGER3(9), PTGFR(6), PTK2B(20), RYR1(81), RYR2(141), RYR3(109), SLC25A4(5), SLC25A5(5), SLC25A6(5), SLC8A1(26), SLC8A2(22), SLC8A3(13), SPHK1(10), SPHK2(11), TACR1(4), TACR2(2), TACR3(18), TBXA2R(11), TNNC1(3), TNNC2(1), TRHR(7), TRPC1(16), VDAC1(5), VDAC2(3), VDAC3(7)	225633460	2675	474	2551	867	924	324	311	639	466	11	0.000113	1.000	1.000
132	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	238	ACVR1B(17), ACVR1C(7), AKT1(7), AKT2(11), AKT3(10), ARRB1(8), ARRB2(3), ATF2(4), ATF4(4), BDNF(12), BRAF(22), CACNA1A(47), CACNA1B(38), CACNA1C(58), CACNA1D(50), CACNA1E(68), CACNA1F(21), CACNA1G(34), CACNA1H(50), CACNA1I(34), CACNA1S(31), CACNA2D1(24), CACNA2D2(9), CACNA2D3(30), CACNA2D4(18), CACNB1(6), CACNB2(20), CACNB3(4), CACNB4(7), CACNG1(5), CACNG2(4), CACNG3(7), CACNG4(4), CACNG5(13), CACNG6(5), CACNG7(11), CACNG8(6), CASP3(2), CD14(2), CDC25B(8), CDC42(3), CHUK(10), CRK(2), CRKL(2), DAXX(14), DDIT3(5), DUSP1(3), DUSP10(11), DUSP14(3), DUSP16(12), DUSP2(1), DUSP3(1), DUSP4(3), DUSP5(10), DUSP6(5), DUSP7(3), DUSP8(2), DUSP9(10), ECSIT(8), EGF(15), EGFR(24), ELK1(6), ELK4(2), FAS(3), FASLG(6), FGF1(5), FGF10(5), FGF11(1), FGF12(9), FGF14(12), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(7), FGF3(3), FGF4(1), FGF5(8), FGF6(8), FGF7(7), FGF8(2), FGF9(11), FGFR1(19), FGFR2(14), FGFR3(10), FGFR4(22), FLNA(31), FLNB(37), FLNC(48), FOS(2), GADD45B(3), GNA12(2), GRB2(4), HRAS(2), IKBKB(12), IL1A(2), IL1B(7), IL1R1(5), IL1R2(13), JUN(6), JUND(2), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K5(3), MAP2K6(1), MAP3K1(24), MAP3K10(17), MAP3K12(17), MAP3K13(14), MAP3K2(9), MAP3K3(10), MAP3K4(32), MAP3K5(18), MAP3K6(14), MAP3K7(14), MAP3K8(2), MAP4K1(4), MAP4K2(14), MAP4K3(8), MAP4K4(16), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK7(9), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), MAPKAPK2(4), MAPKAPK3(5), MAPKAPK5(6), MAPT(12), MAX(4), MEF2C(7), MKNK1(6), MKNK2(10), MOS(11), MRAS(5), MYC(6), NF1(40), NFATC2(32), NFATC4(20), NFKB1(10), NFKB2(11), NR4A1(6), NRAS(5), NTF3(5), NTRK1(14), NTRK2(22), PAK1(7), PAK2(13), PDGFA(4), PDGFB(8), PDGFRA(17), PDGFRB(16), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PPM1A(5), PPM1B(14), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PPP5C(11), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), PTPN5(9), PTPN7(8), PTPRR(16), RAC1(2), RAC2(2), RAC3(4), RAF1(11), RAP1A(4), RAP1B(6), RAPGEF2(20), RASA1(28), RASA2(12), RASGRF1(24), RASGRF2(20), RASGRP1(11), RASGRP2(9), RASGRP3(8), RASGRP4(8), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA4(13), RPS6KA5(9), RRAS(1), RRAS2(3), SOS1(12), SOS2(19), SRF(5), STK3(5), STK4(5), STMN1(3), TAOK1(14), TAOK2(23), TAOK3(14), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TNF(3), TNFRSF1A(6), TRAF2(5), TRAF6(7), ZAK(12)	242823873	2460	465	2356	736	790	301	277	520	556	16	1.36e-05	1.000	1.000
133	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(10), ACTG1(2), CHAD(7), COL11A1(67), COL11A2(26), COL17A1(16), COL1A1(21), COL1A2(39), COL2A1(26), COL3A1(23), COL4A1(35), COL4A2(24), COL4A4(25), COL4A6(15), COL5A1(39), COL5A2(25), COL5A3(22), COL6A1(19), COL6A2(33), COL6A3(67), COL6A6(53), COMP(8), DES(3), DSC1(3), DSC2(14), DSC3(8), DSG1(12), DSG2(12), DSG3(19), DSG4(10), FN1(40), GJA1(14), GJA10(6), GJA3(4), GJA4(8), GJA5(10), GJA8(10), GJA9(2), GJB1(2), GJB3(4), GJB4(5), GJB5(3), GJB6(7), GJB7(4), GJC1(6), GJC2(4), GJC3(1), GJD2(9), GJD4(4), IBSP(9), INA(7), ITGA6(17), ITGB4(29), KRT1(12), KRT10(9), KRT12(10), KRT13(11), KRT14(4), KRT15(6), KRT16(11), KRT17(8), KRT18(5), KRT19(6), KRT2(13), KRT20(6), KRT23(17), KRT24(10), KRT25(11), KRT27(14), KRT28(12), KRT3(11), KRT31(8), KRT32(6), KRT33A(12), KRT33B(10), KRT34(10), KRT35(8), KRT36(7), KRT37(4), KRT38(5), KRT39(9), KRT4(7), KRT40(3), KRT5(7), KRT6A(17), KRT6B(11), KRT6C(13), KRT7(5), KRT71(3), KRT72(17), KRT73(19), KRT74(8), KRT76(6), KRT77(4), KRT78(5), KRT79(10), KRT8(10), KRT81(7), KRT82(6), KRT83(4), KRT84(9), KRT85(7), KRT86(4), KRT9(6), LAMA1(85), LAMA2(51), LAMA3(37), LAMA4(33), LAMA5(58), LAMB1(22), LAMB2(30), LAMB3(22), LAMB4(33), LAMC1(29), LAMC2(14), LAMC3(25), LMNA(13), LMNB1(5), LMNB2(11), NES(25), PRPH(7), RELN(69), SPP1(4), THBS1(19), THBS2(24), THBS3(13), THBS4(18), TNC(35), TNN(38), TNR(36), TNXB(82), VIM(12), VTN(10), VWF(47)	214472298	2238	460	2178	809	694	314	215	587	411	17	0.510	1.000	1.000
134	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(10), ACTN1(8), ACTN2(34), ACTN4(20), APC(68), APC2(19), ARAF(16), ARHGEF1(15), ARHGEF12(18), ARHGEF4(15), ARHGEF6(13), ARHGEF7(13), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), ARPC5(1), ARPC5L(3), BAIAP2(7), BCAR1(16), BDKRB1(4), BDKRB2(3), BRAF(22), CD14(2), CDC42(3), CFL1(2), CFL2(1), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), CRK(2), CRKL(2), CSK(10), CYFIP1(19), CYFIP2(29), DIAPH1(16), DIAPH2(18), DIAPH3(24), DOCK1(29), EGF(15), EGFR(24), EZR(6), F2(15), F2R(10), FGD1(16), FGD3(19), FGF1(5), FGF10(5), FGF11(1), FGF12(9), FGF14(12), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(7), FGF3(3), FGF4(1), FGF5(8), FGF6(8), FGF7(7), FGF8(2), FGF9(11), FGFR1(19), FGFR2(14), FGFR3(10), FGFR4(22), FN1(40), GIT1(4), GNA12(2), GNA13(10), GSN(15), HRAS(2), IQGAP1(22), IQGAP2(15), IQGAP3(24), ITGA1(10), ITGA10(19), ITGA11(18), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGAD(23), ITGAE(19), ITGAL(28), ITGAM(13), ITGAV(23), ITGAX(15), ITGB1(12), ITGB2(12), ITGB3(8), ITGB4(29), ITGB5(10), ITGB6(9), ITGB7(7), ITGB8(18), LIMK1(7), LIMK2(6), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MOS(11), MRAS(5), MSN(18), MYH10(45), MYH14(34), MYH9(44), MYL2(9), MYL7(5), MYL9(3), MYLK(31), MYLK2(9), NCKAP1(17), NCKAP1L(17), NRAS(5), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PDGFA(4), PDGFB(8), PDGFRA(17), PDGFRB(16), PFN1(1), PFN2(1), PFN3(3), PFN4(2), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PIP4K2A(9), PIP4K2B(9), PIP4K2C(2), PIP5K1A(4), PIP5K1B(2), PIP5K1C(15), PPP1CA(3), PPP1CB(1), PPP1CC(4), PPP1R12A(4), PPP1R12B(17), PTK2(12), PXN(9), RAC1(2), RAC2(2), RAC3(4), RAF1(11), RDX(13), ROCK1(22), ROCK2(20), RRAS(1), RRAS2(3), SCIN(14), SLC9A1(14), SOS1(12), SOS2(19), SSH1(14), SSH2(29), SSH3(12), TIAM1(44), TIAM2(29), VAV1(21), VAV2(14), VAV3(16), VCL(19), WAS(4), WASF1(11), WASF2(10), WASL(7)	235607457	2354	460	2254	701	741	295	278	513	512	15	0.000111	1.000	1.000
135	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(27), CD36(7), CD44(8), CD47(1), CHAD(7), COL11A1(67), COL11A2(26), COL1A1(21), COL1A2(39), COL2A1(26), COL3A1(23), COL4A1(35), COL4A2(24), COL4A4(25), COL4A6(15), COL5A1(39), COL5A2(25), COL5A3(22), COL6A1(19), COL6A2(33), COL6A3(67), COL6A6(53), DAG1(14), FN1(40), FNDC1(34), FNDC3A(14), FNDC4(6), FNDC5(3), GP5(15), GP6(5), GP9(3), HMMR(13), HSPG2(87), IBSP(9), ITGA1(10), ITGA10(19), ITGA11(18), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGAV(23), ITGB1(12), ITGB3(8), ITGB4(29), ITGB5(10), ITGB6(9), ITGB7(7), ITGB8(18), LAMA1(85), LAMA2(51), LAMA3(37), LAMA4(33), LAMA5(58), LAMB1(22), LAMB2(30), LAMB3(22), LAMB4(33), LAMC1(29), LAMC2(14), LAMC3(25), RELN(69), SDC1(2), SDC2(3), SDC3(5), SDC4(6), SPP1(4), SV2A(20), SV2B(7), SV2C(15), THBS1(19), THBS2(24), THBS3(13), THBS4(18), TNC(35), TNN(38), TNR(36), TNXB(82), VTN(10), VWF(47)	193883797	2057	443	1952	658	612	272	189	545	423	16	0.0138	1.000	1.000
136	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ADRA1A(26), ADRA1B(6), ADRA1D(9), ADRB1(10), ADRB2(9), ADRB3(6), ANXA6(4), ARRB1(8), ARRB2(3), ATP1A4(24), ATP1B1(8), ATP1B2(4), ATP1B3(4), ATP2A2(9), ATP2A3(14), ATP2B1(21), ATP2B2(27), ATP2B3(26), CACNA1A(47), CACNA1B(38), CACNA1C(58), CACNA1D(50), CACNA1E(68), CACNA1S(31), CACNB1(6), CACNB3(4), CALM1(2), CALM2(3), CALM3(2), CALR(4), CAMK1(4), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), CASQ1(9), CASQ2(4), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), GJA1(14), GJA4(8), GJA5(10), GJB1(2), GJB3(4), GJB4(5), GJB5(3), GJB6(7), GNA11(6), GNAI2(5), GNAI3(9), GNAO1(2), GNAQ(4), GNAZ(19), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(4), GNG13(3), GNG2(2), GNG7(4), GNGT1(4), GRK4(13), GRK5(4), GRK6(5), ITPR1(40), ITPR2(41), ITPR3(46), KCNB1(17), KCNJ3(18), KCNJ5(8), MIB1(5), NME7(4), PEA15(1), PKIA(3), PKIG(1), PLCB3(21), PRKACA(9), PRKACB(6), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCQ(18), PRKCZ(4), PRKD1(30), RGS1(4), RGS10(5), RGS11(7), RGS14(5), RGS16(3), RGS17(5), RGS19(5), RGS2(7), RGS20(9), RGS3(21), RGS4(8), RGS5(2), RGS6(17), RGS7(7), RGS9(13), RYR1(81), RYR2(141), RYR3(109), SFN(1), SLC8A1(26), SLC8A3(13), USP5(11), YWHAB(3), YWHAH(3), YWHAQ(5)	162584175	1896	427	1821	636	634	219	231	443	358	11	0.0169	1.000	1.000
137	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(12), ABLIM1(15), ABLIM2(14), ABLIM3(8), ARHGEF12(18), CDC42(3), CDK5(3), CFL1(2), CFL2(1), CXCR4(1), DCC(52), DPYSL2(5), DPYSL5(14), EFNA1(3), EFNA2(2), EFNA4(6), EFNA5(5), EFNB1(5), EFNB2(7), EFNB3(15), EPHA1(15), EPHA2(34), EPHA3(40), EPHA4(21), EPHA5(40), EPHA6(38), EPHA7(20), EPHA8(23), EPHB1(41), EPHB2(19), EPHB3(14), EPHB4(20), EPHB6(27), FES(14), FYN(10), GNAI1(4), GNAI2(5), GNAI3(9), GSK3B(9), HRAS(2), ITGB1(12), L1CAM(22), LIMK1(7), LIMK2(6), LRRC4C(12), MAPK1(4), MAPK3(3), MET(14), NCK1(7), NCK2(10), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NGEF(8), NRAS(5), NRP1(17), NTN1(8), NTN4(6), NTNG1(25), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PLXNA1(45), PLXNA2(36), PLXNA3(26), PLXNB1(38), PLXNB2(35), PLXNB3(18), PLXNC1(21), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PTK2(12), RAC1(2), RAC2(2), RAC3(4), RASA1(28), RGS3(21), RHOD(3), RND1(2), ROBO1(45), ROBO2(45), ROBO3(20), ROCK1(22), ROCK2(20), SEMA3A(22), SEMA3C(8), SEMA3D(22), SEMA3E(22), SEMA3F(14), SEMA3G(9), SEMA4A(12), SEMA4B(3), SEMA4C(14), SEMA4D(16), SEMA4F(12), SEMA4G(7), SEMA5A(37), SEMA5B(31), SEMA6A(21), SEMA6B(10), SEMA6C(13), SEMA6D(35), SEMA7A(9), SLIT1(15), SLIT2(49), SLIT3(31), SRGAP1(16), SRGAP3(16), UNC5A(16), UNC5B(14), UNC5C(27), UNC5D(34)	168517865	1941	426	1867	582	556	237	231	508	399	10	0.000942	1.000	1.000
138	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTB(10), ACTG1(2), ACTN1(8), ACTN2(34), ACTN4(20), AKT1(7), AKT2(11), AKT3(10), AMOTL1(14), ASH1L(45), CASK(10), CDC42(3), CDK4(2), CGN(19), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(7), CLDN17(8), CLDN18(4), CLDN19(7), CLDN2(2), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(10), CLDN7(1), CLDN8(3), CLDN9(9), CRB3(2), CSNK2A1(6), CSNK2A2(9), CTNNA1(24), CTNNA2(32), CTNNA3(29), CTTN(13), EPB41(16), EPB41L1(14), EPB41L2(16), EPB41L3(49), EXOC3(6), EXOC4(16), F11R(2), GNAI1(4), GNAI2(5), GNAI3(9), HCLS1(4), HRAS(2), IGSF5(5), INADL(24), JAM2(2), JAM3(7), LLGL1(14), LLGL2(12), MAGI1(30), MAGI2(36), MAGI3(14), MLLT4(32), MPDZ(35), MPP5(9), MRAS(5), MYH1(33), MYH10(45), MYH11(36), MYH13(39), MYH14(34), MYH15(21), MYH2(49), MYH3(41), MYH4(32), MYH6(34), MYH7(47), MYH7B(27), MYH8(23), MYH9(44), MYL2(9), MYL7(5), MYL9(3), NRAS(5), OCLN(10), PARD3(24), PARD6A(1), PARD6B(5), PARD6G(2), PPM1J(4), PPP2CA(5), PPP2CB(4), PPP2R1A(18), PPP2R1B(10), PPP2R2A(10), PPP2R2B(9), PPP2R2C(7), PPP2R3A(15), PPP2R3B(17), PPP2R4(5), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCI(8), PRKCQ(18), PRKCZ(4), RAB13(3), RAB3B(5), RRAS(1), RRAS2(3), SPTAN1(30), SRC(5), SYMPK(14), TJAP1(5), TJP1(32), TJP2(19), TJP3(13), VAPA(4), YES1(9), ZAK(12)	165070445	1687	405	1633	511	531	203	199	436	313	5	0.00693	1.000	1.000
139	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(5), ACTA2(12), ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ADM(2), ARRB1(8), ARRB2(3), ATF2(4), ATF3(2), ATF4(4), ATF5(5), ATP2A2(9), ATP2A3(14), CACNB3(4), CALCA(2), CALM1(2), CALM2(3), CALM3(2), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CNN1(4), CNN2(2), CORIN(15), CRHR1(14), DGKZ(12), ETS2(4), FOS(2), GABPA(5), GABPB2(4), GBA2(7), GJA1(14), GNAQ(4), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(4), GNG13(3), GNG2(2), GNG7(4), GNGT1(4), GRK4(13), GRK5(4), GRK6(5), GSTO1(2), GUCA2A(1), GUCA2B(6), GUCY1A3(20), IGFBP1(11), IGFBP2(5), IGFBP3(7), IGFBP4(2), IGFBP6(1), IL1B(7), IL6(1), ITPR1(40), ITPR2(41), ITPR3(46), JUN(6), MAFF(1), MIB1(5), MYL2(9), MYL4(2), MYLK2(9), NFKB1(10), NOS1(45), NOS3(20), OXT(1), OXTR(9), PDE4B(9), PDE4D(11), PKIA(3), PKIG(1), PLCB3(21), PLCD1(7), PLCG1(27), PLCG2(22), PRKACA(9), PRKACB(6), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PRKCD(12), PRKCE(16), PRKCH(9), PRKCQ(18), PRKCZ(4), PRKD1(30), RAMP1(1), RAMP2(2), RAMP3(3), RGS1(4), RGS10(5), RGS11(7), RGS14(5), RGS16(3), RGS17(5), RGS19(5), RGS2(7), RGS20(9), RGS3(21), RGS4(8), RGS5(2), RGS6(17), RGS7(7), RGS9(13), RLN1(5), RYR1(81), RYR2(141), RYR3(109), SFN(1), SLC8A1(26), SP1(6), TNXB(82), USP5(11), YWHAB(3), YWHAH(3), YWHAQ(5)	149729419	1614	401	1547	526	528	185	177	396	320	8	0.0189	1.000	1.000
140	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	ALCAM(14), CADM3(14), CD2(5), CD22(10), CD226(3), CD274(4), CD276(8), CD28(2), CD34(6), CD4(11), CD40(3), CD40LG(6), CD58(8), CD6(13), CD80(6), CD86(8), CD8A(4), CD8B(2), CD99(1), CDH15(11), CDH2(27), CDH3(14), CDH4(31), CDH5(15), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(7), CLDN17(8), CLDN18(4), CLDN19(7), CLDN2(2), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(10), CLDN7(1), CLDN8(3), CLDN9(9), CNTN1(34), CNTN2(15), CNTNAP1(23), CNTNAP2(47), CTLA4(4), ESAM(6), F11R(2), GLG1(21), HLA-C(11), HLA-DMA(1), HLA-DMB(7), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(3), HLA-DPB1(5), HLA-DQA2(7), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(2), HLA-DRB5(3), HLA-E(7), HLA-F(8), HLA-G(7), ICAM1(5), ICAM2(4), ICAM3(7), ICOS(4), ICOSLG(2), ITGA4(21), ITGA6(17), ITGA8(22), ITGA9(11), ITGAL(28), ITGAM(13), ITGAV(23), ITGB1(12), ITGB2(12), ITGB7(7), ITGB8(18), JAM2(2), JAM3(7), L1CAM(22), MADCAM1(4), MAG(24), MPZ(2), MPZL1(5), NCAM1(13), NCAM2(39), NEGR1(14), NEO1(22), NFASC(42), NLGN1(31), NLGN2(11), NLGN3(15), NRCAM(16), NRXN1(51), NRXN2(37), NRXN3(45), OCLN(10), PDCD1(6), PDCD1LG2(4), PTPRC(30), PTPRF(24), PTPRM(43), PVR(5), PVRL1(9), PVRL2(9), PVRL3(12), SDC1(2), SDC2(3), SDC3(5), SDC4(6), SELE(9), SELL(7), SELP(14), SELPLG(10), SIGLEC1(31), SPN(5), VCAM1(13), VCAN(59)	123435486	1461	395	1380	449	414	197	175	381	289	5	0.000310	1.000	1.000
141	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(5), ACTA2(12), ACTN2(34), ACTN4(20), DES(3), DMD(87), MYBPC1(13), MYBPC2(18), MYBPC3(18), MYH3(41), MYH6(34), MYH7(47), MYH8(23), MYL1(3), MYL2(9), MYL3(6), MYL4(2), MYL9(3), MYOM1(22), NEB(90), TCAP(4), TMOD1(4), TNNC2(1), TNNI1(1), TNNI2(6), TNNI3(1), TNNT1(6), TNNT2(6), TNNT3(7), TPM1(5), TPM2(3), TPM3(4), TPM4(5), TTN(728), VIM(12)	118443417	1283	391	1238	388	318	155	194	468	128	20	0.0580	1.000	1.000
142	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	ACVR1(6), ACVR1B(17), ACVR2A(11), ACVR2B(6), AMHR2(11), BMP2(8), BMP7(9), BMPR1A(13), BMPR1B(13), BMPR2(24), CCL1(3), CCL11(1), CCL13(1), CCL14(2), CCL15(2), CCL16(3), CCL18(4), CCL19(2), CCL2(1), CCL20(5), CCL22(3), CCL23(1), CCL24(2), CCL25(1), CCL27(2), CCL28(2), CCL3(1), CCL5(4), CCL7(2), CCL8(3), CCR1(8), CCR2(6), CCR3(14), CCR4(3), CCR5(5), CCR6(2), CCR7(5), CCR8(4), CCR9(8), CD27(2), CD40(3), CD40LG(6), CD70(3), CLCF1(4), CNTF(4), CNTFR(6), CRLF2(3), CSF1(6), CSF1R(26), CSF2RA(12), CSF2RB(18), CSF3(3), CSF3R(18), CX3CL1(10), CX3CR1(7), CXCL1(1), CXCL10(1), CXCL14(1), CXCL2(2), CXCL3(1), CXCL5(1), CXCL6(1), CXCL9(2), CXCR3(3), CXCR4(1), CXCR6(2), EDA(5), EDA2R(5), EDAR(9), EGF(15), EGFR(24), EPO(3), EPOR(5), FAS(3), FASLG(6), FLT1(26), FLT3(21), FLT3LG(2), FLT4(36), GDF5(15), GH1(3), GH2(4), GHR(11), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNAR1(9), IFNAR2(4), IFNB1(4), IFNG(3), IFNGR1(11), IFNGR2(2), IFNK(1), IFNW1(4), IL10(4), IL10RA(8), IL10RB(3), IL11(3), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL13(4), IL13RA1(6), IL15(2), IL15RA(6), IL17B(4), IL17RA(11), IL17RB(7), IL18(1), IL18R1(7), IL18RAP(4), IL19(2), IL1A(2), IL1B(7), IL1R1(5), IL1R2(13), IL1RAP(8), IL20(3), IL20RA(5), IL21(5), IL21R(10), IL22(2), IL22RA1(4), IL22RA2(2), IL23A(3), IL23R(8), IL25(4), IL26(5), IL2RA(3), IL2RB(3), IL2RG(12), IL3(3), IL3RA(6), IL4(4), IL4R(10), IL5RA(12), IL6(1), IL6R(4), IL6ST(11), IL7(2), IL7R(18), IL9R(5), INHBA(19), INHBB(13), INHBC(8), INHBE(6), KDR(22), KIT(20), KITLG(6), LEP(3), LEPR(18), LIF(4), LIFR(18), LTA(4), LTBR(2), MET(14), MPL(7), NGFR(9), OSM(4), OSMR(13), PDGFB(8), PDGFC(11), PDGFRA(17), PDGFRB(16), PF4(2), PF4V1(3), PLEKHO2(3), PRL(3), PRLR(8), RELT(9), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TNF(3), TNFRSF10A(3), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(3), TNFRSF11A(5), TNFRSF11B(6), TNFRSF12A(2), TNFRSF13B(7), TNFRSF13C(4), TNFRSF14(2), TNFRSF17(1), TNFRSF18(1), TNFRSF19(10), TNFRSF1A(6), TNFRSF1B(4), TNFRSF21(6), TNFRSF25(9), TNFRSF4(6), TNFRSF8(12), TNFRSF9(12), TNFSF10(10), TNFSF11(5), TNFSF12(2), TNFSF13(6), TNFSF13B(5), TNFSF14(4), TNFSF15(5), TNFSF18(2), TNFSF4(2), TNFSF8(4), TNFSF9(2), TPO(35), TSLP(2), VEGFB(2), VEGFC(17), XCL1(1), XCL2(1), XCR1(7)	150596097	1440	387	1374	482	358	195	172	374	335	6	0.215	1.000	1.000
143	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	137	APC(68), APC2(19), AXIN1(17), AXIN2(22), BTRC(12), CACYBP(4), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CCND1(3), CCND2(2), CCND3(1), CER1(4), CHD8(36), CREBBP(59), CSNK1A1(7), CSNK1A1L(8), CSNK1E(10), CSNK2A1(6), CSNK2A2(9), CTBP1(5), CTBP2(10), CTNNBIP1(3), CUL1(28), CXXC4(5), DAAM1(21), DAAM2(22), DKK1(12), DKK2(11), DKK4(7), DVL1(8), DVL2(11), DVL3(17), EP300(39), FBXW11(9), FOSL1(3), FZD1(15), FZD10(22), FZD2(17), FZD3(13), FZD4(9), FZD5(6), FZD6(13), FZD7(15), FZD8(14), FZD9(5), GSK3B(9), JUN(6), LEF1(5), LRP5(35), LRP6(16), MAP3K7(14), MAPK10(7), MAPK8(7), MAPK9(7), MMP7(2), MYC(6), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NKD1(8), NKD2(7), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PORCN(6), PPARD(8), PPP2CA(5), PPP2CB(4), PPP2R1A(18), PPP2R1B(10), PPP2R2A(10), PPP2R2B(9), PPP2R2C(7), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRICKLE1(24), PRICKLE2(22), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), PSEN1(7), RAC1(2), RAC2(2), RAC3(4), RBX1(1), ROCK1(22), ROCK2(20), RUVBL1(9), SENP2(10), SFRP1(9), SFRP2(7), SFRP4(8), SFRP5(1), SIAH1(3), SMAD2(11), SMAD3(9), SOX17(16), TBL1X(10), TBL1XR1(11), TBL1Y(2), TCF7(9), TCF7L1(10), TCF7L2(12), VANGL1(8), VANGL2(14), WIF1(5), WNT10A(6), WNT10B(3), WNT11(3), WNT2(6), WNT2B(14), WNT3(6), WNT3A(9), WNT4(2), WNT5A(8), WNT5B(6), WNT6(4), WNT7A(6), WNT7B(10), WNT8A(2), WNT8B(2), WNT9A(9), WNT9B(6)	133306616	1494	380	1426	398	491	190	156	299	346	12	7.80e-08	1.000	1.000
144	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(7), ADORA2A(7), ADORA2B(4), ADORA3(9), ADRA1A(26), ADRA1B(6), ADRA1D(9), ADRA2A(12), ADRA2C(6), ADRB1(10), ADRB2(9), ADRB3(6), AGTR1(1), AGTR2(6), AVPR1A(20), AVPR1B(3), AVPR2(12), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(13), CCKAR(8), CCKBR(19), CCR1(8), CCR10(4), CCR2(6), CCR3(14), CCR4(3), CCR5(5), CCR6(2), CCR7(5), CCR8(4), CCR9(8), CCRL2(1), CHML(13), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), CMKLR1(11), CNR1(16), CNR2(4), CX3CR1(7), CXCR3(3), CXCR4(1), DRD1(7), DRD2(14), DRD3(9), DRD4(6), DRD5(13), EDNRA(5), F2R(10), F2RL1(2), F2RL2(5), F2RL3(6), FPR1(9), FSHR(30), GALR1(8), GALR2(14), GALR3(5), GALT(3), GHSR(10), GNB2L1(5), GPR17(7), GPR173(8), GPR174(5), GPR27(8), GPR3(4), GPR35(5), GPR37(15), GPR37L1(10), GPR4(6), GPR50(12), GPR6(11), GPR63(6), GPR83(9), GPR85(6), GPR87(8), GRPR(7), HCRTR1(6), HCRTR2(14), HRH1(7), HRH2(9), HRH3(8), HTR1A(18), HTR1B(11), HTR1D(9), HTR1E(18), HTR1F(10), HTR2A(12), HTR2B(5), HTR2C(11), HTR4(5), HTR5A(14), HTR6(7), HTR7(17), LTB4R(2), MAS1(4), MC1R(8), MC3R(12), MC4R(11), MC5R(6), MLNR(5), MTNR1A(5), MTNR1B(10), NMBR(3), NMUR1(7), NMUR2(7), NPY1R(6), NPY2R(8), NPY5R(5), NTSR1(11), NTSR2(7), OPN1SW(2), OPN3(6), OPRD1(5), OPRK1(19), OPRL1(11), OPRM1(9), OR10A5(7), OR11A1(7), OR12D3(6), OR1C1(7), OR1F1(5), OR1Q1(8), OR2H1(3), OR5V1(9), OR7A5(3), OR7C1(8), OR8B8(7), OXTR(9), P2RY1(5), P2RY10(14), P2RY11(5), P2RY12(10), P2RY13(7), P2RY14(6), P2RY2(5), P2RY6(12), PTAFR(4), PTGDR(8), PTGER2(8), PTGER4(15), PTGFR(6), PTGIR(2), RGR(4), RHO(10), RRH(5), SSTR1(12), SSTR2(4), SSTR3(11), SSTR4(18), SUCNR1(6), TBXA2R(11), TRHR(7)	101587761	1294	374	1233	481	452	151	171	336	184	0	0.0741	1.000	1.000
145	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(7), ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ADK(4), ADSL(8), ADSS(6), ADSSL1(10), AK1(1), AK5(8), AK7(7), ALLC(10), AMPD1(15), AMPD2(19), AMPD3(19), APRT(3), ATIC(7), CANT1(5), DCK(5), DGUOK(5), ENPP1(12), ENPP3(16), ENTPD1(6), ENTPD2(7), ENTPD3(6), ENTPD4(14), ENTPD5(5), ENTPD6(7), ENTPD8(7), FHIT(4), GART(12), GDA(8), GMPR(3), GMPR2(2), GMPS(10), GUCY1A2(17), GUCY1A3(20), GUCY1B3(10), GUCY2C(19), GUCY2D(19), GUCY2F(15), GUK1(4), IMPDH1(7), ITPA(1), NME2(3), NME4(2), NME6(4), NME7(4), NPR1(17), NPR2(14), NT5C1A(9), NT5C1B(14), NT5C2(9), NT5E(5), NT5M(7), NUDT2(5), NUDT5(1), NUDT9(2), PAPSS1(6), PAPSS2(9), PDE10A(24), PDE11A(16), PDE1A(10), PDE1C(17), PDE2A(19), PDE3B(26), PDE4A(13), PDE4B(9), PDE4C(10), PDE4D(11), PDE5A(11), PDE6D(1), PDE6G(1), PDE6H(3), PDE7A(8), PDE7B(5), PDE8A(16), PDE8B(11), PDE9A(10), PFAS(16), PKLR(12), PNPT1(6), POLA1(8), POLA2(6), POLD1(18), POLD2(8), POLD3(7), POLE(42), POLE2(6), POLE3(4), POLE4(1), POLR1A(23), POLR1B(11), POLR1C(9), POLR1D(4), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLR3A(31), POLR3B(16), POLR3G(3), POLR3H(2), POLR3K(2), PPAT(7), PRIM1(6), PRIM2(10), PRPS1(4), PRPS2(5), PRUNE(5), RFC5(3), RRM1(5), RRM2(3), RRM2B(5), XDH(32), ZNRD1(2)	140866896	1303	368	1264	420	366	169	185	331	249	3	0.121	1.000	1.000
146	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(36), ACACB(49), AKT1(7), AKT2(11), AKT3(10), ARAF(16), BAD(4), BRAF(22), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CBL(11), CBLB(6), CBLC(10), CRK(2), CRKL(2), EIF4EBP1(5), ELK1(6), EXOC7(15), FASN(34), FBP1(4), FBP2(8), FLOT2(14), FOXO1(7), G6PC2(1), GCK(10), GRB2(4), GSK3B(9), GYS1(10), GYS2(11), HRAS(2), IKBKB(12), INPP5D(12), INSR(26), IRS1(33), IRS2(13), IRS4(28), LIPE(9), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(7), MKNK1(6), MKNK2(10), NRAS(5), PCK1(14), PCK2(12), PDE3A(26), PDE3B(26), PDPK1(1), PFKL(9), PFKM(6), PFKP(23), PHKA1(15), PHKA2(18), PHKB(11), PHKG1(4), PHKG2(13), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PKLR(12), PPARGC1A(16), PPP1CA(3), PPP1CB(1), PPP1CC(4), PPP1R3A(39), PPP1R3B(7), PPP1R3C(4), PPP1R3D(5), PRKAA1(9), PRKAA2(11), PRKAB2(6), PRKACA(9), PRKACB(6), PRKACG(9), PRKAG1(6), PRKAG2(8), PRKAG3(8), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCI(8), PRKCZ(4), PRKX(6), PTPN1(8), PTPRF(24), PYGB(17), PYGL(14), PYGM(18), RAF1(11), RAPGEF1(15), RHEB(3), RPS6(1), RPS6KB1(6), RPS6KB2(9), SH2B2(5), SHC1(7), SHC2(3), SHC3(12), SHC4(11), SLC2A4(5), SOCS1(1), SOCS2(2), SOCS3(4), SOCS4(8), SORBS1(19), SOS1(12), SOS2(19), SREBF1(18), TRIP10(18), TSC1(20), TSC2(21)	135041193	1350	364	1298	403	419	178	140	285	320	8	0.00298	1.000	1.000
147	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ADRB1(10), CSNK1D(5), DRD1(7), DRD2(14), EGF(15), EGFR(24), GJA1(14), GJD2(9), GNA11(6), GNAI1(4), GNAI2(5), GNAI3(9), GNAQ(4), GNAS(54), GRB2(4), GRM1(52), GUCY1A2(17), GUCY1A3(20), GUCY1B3(10), GUCY2C(19), GUCY2D(19), GUCY2F(15), HRAS(2), HTR2A(12), HTR2B(5), HTR2C(11), ITPR1(40), ITPR2(41), ITPR3(46), MAP2K1(9), MAP2K2(6), MAP2K5(3), MAP3K2(9), MAPK1(4), MAPK3(3), MAPK7(9), NPR1(17), NPR2(14), NRAS(5), PDGFA(4), PDGFB(8), PDGFC(11), PDGFD(11), PDGFRA(17), PDGFRB(16), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKG1(15), PRKG2(20), PRKX(6), RAF1(11), SOS1(12), SOS2(19), SRC(5), TJP1(32), TUBA1A(5), TUBA1B(3), TUBA1C(4), TUBA3C(17), TUBA3D(12), TUBA3E(11), TUBA4A(3), TUBA8(11), TUBAL3(8), TUBB(1), TUBB1(9), TUBB2A(7), TUBB2B(5), TUBB3(12), TUBB6(9), TUBB8(10)	111975184	1234	359	1186	414	390	171	144	317	206	6	0.107	1.000	1.000
148	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(7), AKT2(11), AKT3(10), BCL2L1(2), CBL(11), CBLB(6), CBLC(10), CCND1(3), CCND2(2), CCND3(1), CISH(4), CLCF1(4), CNTF(4), CNTFR(6), CREBBP(59), CRLF2(3), CSF2RA(12), CSF2RB(18), CSF3(3), CSF3R(18), EP300(39), EPO(3), EPOR(5), GH1(3), GH2(4), GHR(11), GRB2(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNAR1(9), IFNAR2(4), IFNB1(4), IFNG(3), IFNGR1(11), IFNGR2(2), IFNK(1), IFNW1(4), IL10(4), IL10RA(8), IL10RB(3), IL11(3), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL13(4), IL13RA1(6), IL13RA2(10), IL15(2), IL15RA(6), IL19(2), IL20(3), IL20RA(5), IL21(5), IL21R(10), IL22(2), IL22RA1(4), IL22RA2(2), IL23A(3), IL23R(8), IL26(5), IL2RA(3), IL2RB(3), IL2RG(12), IL3(3), IL3RA(6), IL4(4), IL4R(10), IL5RA(12), IL6(1), IL6R(4), IL6ST(11), IL7(2), IL7R(18), IL9R(5), IRF9(7), JAK1(22), JAK2(14), JAK3(18), LEP(3), LEPR(18), LIF(4), LIFR(18), MPL(7), MYC(6), OSM(4), OSMR(13), PIAS1(17), PIAS2(14), PIAS3(11), PIAS4(9), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PIM1(2), PRL(3), PRLR(8), PTPN11(10), PTPN6(6), SOCS1(1), SOCS2(2), SOCS3(4), SOCS4(8), SOCS5(9), SOCS7(5), SOS1(12), SOS2(19), SPRED1(15), SPRED2(10), SPRY1(2), SPRY3(8), SPRY4(8), STAM(11), STAM2(9), STAT1(14), STAT2(10), STAT3(9), STAT4(14), STAT5A(13), STAT5B(15), STAT6(10), TPO(35), TSLP(2), TYK2(15)	123395061	1151	349	1090	351	270	151	146	299	280	5	0.149	1.000	1.000
149	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(16), BRAF(22), CACNA1A(47), CRHR1(14), GNA11(6), GNA12(2), GNA13(10), GNAI1(4), GNAI2(5), GNAI3(9), GNAO1(2), GNAQ(4), GNAS(54), GNAZ(19), GRIA1(31), GRIA2(34), GRIA3(16), GRID2(30), GRM1(52), GUCY1A2(17), GUCY1A3(20), GUCY1B3(10), GUCY2C(19), GUCY2D(19), GUCY2F(15), HRAS(2), IGF1(3), IGF1R(24), ITPR1(40), ITPR2(41), ITPR3(46), LYN(9), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), NOS1(45), NOS3(20), NPR1(17), NPR2(14), NRAS(5), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PPP2CA(5), PPP2CB(4), PPP2R1A(18), PPP2R1B(10), PPP2R2A(10), PPP2R2B(9), PPP2R2C(7), PRKCA(9), PRKCG(19), PRKG1(15), PRKG2(20), RAF1(11), RYR1(81)	92962023	1107	342	1052	314	362	143	131	277	187	7	0.000416	1.000	1.000
150	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ATF4(4), CACNA1C(58), CACNA1D(50), CACNA1F(21), CACNA1S(31), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CDC42(3), CGA(1), EGFR(24), ELK1(6), FSHB(1), GNA11(6), GNAQ(4), GNAS(54), GNRH1(3), GNRH2(2), GNRHR(5), GRB2(4), HBEGF(2), HRAS(2), ITPR1(40), ITPR2(41), ITPR3(46), JUN(6), LHB(3), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K1(24), MAP3K2(9), MAP3K3(10), MAP3K4(32), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK7(9), MAPK8(7), MAPK9(7), MMP14(11), MMP2(13), NRAS(5), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLD1(26), PLD2(22), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCD(12), PRKX(6), PTK2B(20), RAF1(11), SOS1(12), SOS2(19), SRC(5)	109161892	1152	329	1108	372	368	149	132	267	227	9	0.0600	1.000	1.000
151	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(7), AKT3(10), BCAR1(16), CAPN1(8), CAPN10(10), CAPN11(10), CAPN2(11), CAPN3(11), CAPN5(14), CAPN6(13), CAPN7(7), CAPN9(7), CAPNS1(6), CAV1(6), CAV2(1), CAV3(2), CDC42(3), CRK(2), CSK(10), DOCK1(29), FYN(10), GIT2(7), GRB2(4), ILK(11), ITGA10(19), ITGA11(18), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGAD(23), ITGAE(19), ITGAL(28), ITGAM(13), ITGAV(23), ITGAX(15), ITGB1(12), ITGB2(12), ITGB3(8), ITGB4(29), ITGB5(10), ITGB6(9), ITGB7(7), ITGB8(18), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K6(1), MAPK10(7), MAPK12(1), MAPK4(10), MAPK6(6), MAPK7(9), MYLK2(9), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PDPK1(1), PIK3R2(16), PTK2(12), PXN(9), RAC1(2), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(15), RHO(10), ROCK1(22), ROCK2(20), SDCCAG8(9), SHC1(7), SHC3(12), SORBS1(19), SOS1(12), SRC(5), TLN1(35), TNS1(46), VASP(2), VAV2(14), VAV3(16), VCL(19), ZYX(8)	115902980	1074	329	1035	313	318	151	128	226	245	6	0.00135	1.000	1.000
152	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	106	ACTN1(8), ACTN2(34), ACTN4(20), ARHGAP5(34), BCAR1(16), CD99(1), CDC42(3), CDH5(15), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(7), CLDN17(8), CLDN18(4), CLDN19(7), CLDN2(2), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(10), CLDN7(1), CLDN8(3), CLDN9(9), CTNNA1(24), CTNNA2(32), CTNNA3(29), CXCR4(1), CYBA(2), CYBB(10), ESAM(6), EZR(6), F11R(2), GNAI1(4), GNAI2(5), GNAI3(9), ICAM1(5), ITGA4(21), ITGAL(28), ITGAM(13), ITGB1(12), ITGB2(12), ITK(12), JAM2(2), JAM3(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MLLT4(32), MMP2(13), MMP9(23), MSN(18), MYL2(9), MYL7(5), MYL9(3), NCF1(4), NCF2(3), NCF4(5), NOX1(8), NOX3(12), OCLN(10), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG1(27), PLCG2(22), PRKCA(9), PRKCG(19), PTK2(12), PTK2B(20), PTPN11(10), PXN(9), RAC1(2), RAC2(2), RAP1A(4), RAP1B(6), RAPGEF3(5), RAPGEF4(22), RASSF5(6), RHOH(1), ROCK1(22), ROCK2(20), SIPA1(12), THY1(1), TXK(3), VASP(2), VAV1(21), VAV2(14), VAV3(16), VCAM1(13), VCL(19)	101982699	1053	328	1002	331	327	138	114	237	226	11	0.0244	1.000	1.000
153	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(12), ANAPC1(22), ANAPC10(2), ANAPC11(1), ANAPC2(9), ANAPC4(4), ANAPC5(8), ANAPC7(7), ATM(71), ATR(33), BUB1(15), BUB1B(16), BUB3(4), CCNA1(13), CCNA2(2), CCNB1(4), CCNB2(1), CCNB3(24), CCND1(3), CCND2(2), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDC14A(21), CDC14B(8), CDC16(7), CDC20(10), CDC23(7), CDC25A(8), CDC25B(8), CDC25C(11), CDC26(3), CDC27(12), CDC6(13), CDC7(8), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN1B(1), CDKN2B(1), CDKN2C(2), CDKN2D(5), CHEK1(7), CHEK2(13), CREBBP(59), CUL1(28), DBF4(10), E2F1(6), E2F3(4), EP300(39), ESPL1(29), FZR1(12), GADD45B(3), GSK3B(9), HDAC1(10), HDAC2(6), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(15), MCM3(8), MCM4(17), MCM5(11), MCM6(13), MCM7(8), MDM2(10), PCNA(2), PKMYT1(8), PLK1(18), PRKDC(70), PTTG1(2), RB1(22), RBL1(14), RBL2(11), RBX1(1), SFN(1), SKP2(6), SMAD2(11), SMAD3(9), SMC1A(7), SMC1B(13), TFDP1(6), TGFB1(3), TGFB2(10), TGFB3(11), WEE1(7), YWHAB(3), YWHAE(5), YWHAG(4), YWHAH(3), YWHAQ(5), YWHAZ(4)	114433629	999	326	944	247	227	117	132	236	281	6	0.00136	1.000	1.000
154	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), AKAP1(6), AKAP10(5), AKAP11(21), AKAP12(24), AKAP2(23), AKAP3(16), AKAP4(14), AKAP5(2), AKAP6(41), AKAP7(2), AKAP8(12), AKAP9(55), ARHGEF1(15), CALM1(2), CALM2(3), CALM3(2), CHMP1B(2), GNA11(6), GNA12(2), GNA13(10), GNA14(6), GNA15(6), GNAI2(5), GNAI3(9), GNAL(5), GNAO1(2), GNAQ(4), GNAZ(19), GNB1(2), GNB2(5), GNB3(2), GNB5(4), GNG10(1), GNG13(3), GNG7(4), GNGT1(4), GNGT2(3), HRAS(2), IL18BP(3), ITPR1(40), KCNJ3(18), NRAS(5), PALM2(11), PDE1A(10), PDE1B(8), PDE1C(17), PDE4A(13), PDE4B(9), PDE4C(10), PDE4D(11), PDE7A(8), PDE7B(5), PDE8A(16), PDE8B(11), PLCB3(21), PPP3CA(14), PPP3CC(9), PRKACA(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCI(8), PRKCQ(18), PRKCZ(4), PRKD1(30), PRKD3(7), RRAS(1), SLC9A1(14), USP5(11)	99621690	1019	325	974	323	289	125	140	256	206	3	0.0466	1.000	1.000
155	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(7), ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADK(4), ADSL(8), ADSS(6), AK1(1), AK5(8), ALLC(10), AMPD1(15), AMPD2(19), AMPD3(19), APRT(3), ATIC(7), ATP1B1(8), ATP5A1(5), ATP5B(10), ATP5C1(7), ATP5F1(5), ATP5G2(2), ATP5G3(2), ATP5H(1), ATP5J(3), ATP5J2(1), CANT1(5), DCK(5), DGUOK(5), ENPP1(12), ENPP3(16), ENTPD1(6), ENTPD2(7), FHIT(4), GART(12), GDA(8), GMPS(10), GUCY1A2(17), GUCY1A3(20), GUCY1B3(10), GUCY2C(19), GUCY2D(19), GUCY2F(15), GUK1(4), IMPDH1(7), ITPA(1), NME2(3), NPR1(17), NPR2(14), NT5E(5), NT5M(7), NUDT2(5), PAPSS1(6), PAPSS2(9), PDE1A(10), PDE4A(13), PDE4B(9), PDE4C(10), PDE4D(11), PDE5A(11), PDE6B(15), PDE6C(8), PDE6G(1), PDE7B(5), PDE8A(16), PDE9A(10), PFAS(16), PKLR(12), POLB(8), POLD1(18), POLD2(8), POLE(42), POLG(10), POLL(4), POLQ(46), POLR1B(11), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLRMT(17), PPAT(7), PRPS1(4), PRPS2(5), PRUNE(5), RRM1(5), RRM2(3)	110487457	1015	325	986	349	272	145	145	251	199	3	0.523	1.000	1.000
156	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	65	ACP1(9), ACTB(10), ACTG1(2), ACTN1(8), ACTN2(34), ACTN4(20), ACVR1B(17), ACVR1C(7), BAIAP2(7), CDC42(3), CREBBP(59), CSNK2A1(6), CSNK2A2(9), CTNNA1(24), CTNNA2(32), CTNNA3(29), EGFR(24), EP300(39), FARP2(9), FER(16), FGFR1(19), FYN(10), IGF1R(24), INSR(26), IQGAP1(22), LEF1(5), LMO7(28), MAP3K7(14), MAPK1(4), MAPK3(3), MET(14), MLLT4(32), PARD3(24), PTPN1(8), PTPN6(6), PTPRB(28), PTPRF(24), PTPRJ(36), PTPRM(43), PVRL1(9), PVRL2(9), PVRL3(12), PVRL4(12), RAC1(2), RAC2(2), RAC3(4), SMAD2(11), SMAD3(9), SNAI1(3), SORBS1(19), SRC(5), SSX2IP(12), TCF7(9), TCF7L1(10), TCF7L2(12), TGFBR1(10), TJP1(32), VCL(19), WAS(4), WASF1(11), WASF2(10), WASL(7), YES1(9)	92347965	976	321	942	286	290	135	110	212	222	7	0.00296	1.000	1.000
157	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(18), AMY2A(9), AMY2B(23), ASCC3(41), ATP13A2(20), DDX18(17), DDX19A(8), DDX23(15), DDX4(12), DDX41(11), DDX47(2), DDX50(14), DDX51(11), DDX52(8), DDX54(18), DDX55(7), DDX56(11), DHX58(12), ENPP1(12), ENPP3(16), ENTPD7(11), EP400(55), ERCC2(11), ERCC3(9), G6PC2(1), GAA(11), GANC(10), GBA(14), GBE1(10), GCK(10), GPI(6), GUSB(12), GYS1(10), GYS2(11), HK1(18), HK2(15), HK3(13), IFIH1(13), LYZL1(4), MGAM(28), MOV10L1(13), NUDT5(1), NUDT8(2), PGM1(4), PGM3(13), PYGB(17), PYGL(14), PYGM(18), RAD54B(5), RAD54L(5), RUVBL2(10), SETX(31), SI(49), SKIV2L2(18), SMARCA2(39), SMARCA5(12), TREH(3), UGDH(11), UGP2(9), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7), UXS1(9)	106848765	952	311	912	274	223	112	131	259	224	3	0.0955	1.000	1.000
158	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	94	ADCY1(26), ADCY2(25), ADCY3(21), ADCY4(13), ADCY5(22), ADCY6(19), ADCY7(23), ADCY8(48), ADCY9(23), ASIP(2), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CREB1(4), CREB3L1(7), CREB3L2(5), CREB3L3(6), CREB3L4(4), CREBBP(59), DCT(20), DVL1(8), DVL2(11), DVL3(17), EDN1(4), EP300(39), FZD1(15), FZD10(22), FZD2(17), FZD3(13), FZD4(9), FZD5(6), FZD6(13), FZD7(15), FZD8(14), FZD9(5), GNAI1(4), GNAI2(5), GNAI3(9), GNAO1(2), GNAQ(4), GNAS(54), GSK3B(9), HRAS(2), KIT(20), KITLG(6), LEF1(5), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MC1R(8), MITF(11), NRAS(5), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), POMC(11), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), RAF1(11), TCF7(9), TCF7L1(10), TCF7L2(12), TYR(18), TYRP1(10), WNT10A(6), WNT10B(3), WNT11(3), WNT2(6), WNT2B(14), WNT3(6), WNT3A(9), WNT4(2), WNT5A(8), WNT5B(6), WNT6(4), WNT7A(6), WNT7B(10), WNT8A(2), WNT8B(2), WNT9A(9), WNT9B(6)	90166957	1053	310	1004	349	383	122	131	225	188	4	0.0167	1.000	1.000
159	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(32), ABCA10(29), ABCA12(58), ABCA13(82), ABCA2(34), ABCA3(25), ABCA4(26), ABCA5(26), ABCA6(27), ABCA7(27), ABCA8(17), ABCA9(22), ABCB1(40), ABCB10(16), ABCB11(17), ABCB4(33), ABCB5(24), ABCB6(18), ABCB7(6), ABCB8(14), ABCB9(6), ABCC1(17), ABCC10(15), ABCC11(28), ABCC12(23), ABCC2(23), ABCC3(16), ABCC4(26), ABCC5(18), ABCC6(17), ABCC8(29), ABCC9(57), ABCD1(10), ABCD2(8), ABCD3(6), ABCD4(9), ABCG1(15), ABCG2(11), ABCG4(5), ABCG5(4), ABCG8(9), CFTR(23), TAP1(5), TAP2(11)	102163366	964	308	917	245	247	140	119	229	222	7	1.32e-06	1.000	1.000
160	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(2), CALM2(3), CALM3(2), CALML3(1), CDIPT(1), CDS1(6), CDS2(4), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKI(27), DGKQ(5), DGKZ(12), FN3K(6), IMPA1(8), IMPA2(2), INPP1(4), INPP4A(12), INPP4B(15), INPP5A(11), INPP5B(12), INPP5D(12), INPP5E(11), INPPL1(29), ITPK1(7), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), OCRL(10), PI4KA(29), PI4KB(11), PIK3C2A(20), PIK3C2B(25), PIK3C2G(18), PIK3C3(17), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PIP4K2A(9), PIP4K2B(9), PIP4K2C(2), PIP5K1A(4), PIP5K1B(2), PIP5K1C(15), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCD3(11), PLCD4(8), PLCE1(27), PLCG1(27), PLCG2(22), PLCZ1(14), PRKCA(9), PRKCG(19), PTPMT1(2), SYNJ1(18), SYNJ2(24)	105258098	965	308	917	256	294	122	107	213	219	10	0.000245	1.000	1.000
161	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(12), ACTN1(8), ACTR2(2), ACTR3(3), AKT1(7), AKT2(11), AKT3(10), ANGPTL2(9), ARHGEF6(13), ARHGEF7(13), BCAR1(16), BRAF(22), CAV1(6), CDC42(3), CRK(2), CSE1L(11), DOCK1(29), EPHB2(19), FYN(10), GRB2(4), GRB7(9), ILK(11), ITGA1(10), ITGA10(19), ITGA11(18), ITGA2(18), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGA7(21), ITGA8(22), ITGA9(11), ITGB3BP(1), MAP2K4(12), MAP3K11(12), MAPK1(4), MAPK10(7), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), MRAS(5), MYLK(31), MYLK2(9), P4HB(5), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PIK3CB(17), PKLR(12), PLCG1(27), PLCG2(22), PTK2(12), RAF1(11), RALA(1), RHO(10), ROCK1(22), ROCK2(20), SHC1(7), SOS1(12), SOS2(19), SRC(5), TERF2IP(6), TLN1(35), TLN2(43), VASP(2), WAS(4), ZYX(8)	101843375	905	308	879	269	276	132	88	198	205	6	0.0205	1.000	1.000
162	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(16), BID(3), BRAF(22), CASP3(2), CD244(5), CD247(4), CD48(1), FAS(3), FASLG(6), FCGR3A(6), FYN(10), GRB2(4), GZMB(2), HCST(1), HLA-C(11), HLA-E(7), HLA-G(7), HRAS(2), ICAM1(5), ICAM2(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNAR1(9), IFNAR2(4), IFNB1(4), IFNG(3), IFNGR1(11), IFNGR2(2), ITGAL(28), ITGB2(12), KIR2DL3(9), KIR3DL1(13), KIR3DL2(5), KLRC1(4), KLRC2(2), KLRC3(10), KLRD1(5), KLRK1(8), LAT(3), LCK(5), LCP2(14), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MICA(4), MICB(6), NCR1(5), NCR2(5), NCR3(1), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NRAS(5), PAK1(7), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG1(27), PLCG2(22), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRF1(17), PRKCA(9), PRKCG(19), PTK2B(20), PTPN11(10), PTPN6(6), RAC1(2), RAC2(2), RAC3(4), RAF1(11), SH2D1A(1), SH2D1B(3), SH3BP2(7), SHC1(7), SHC2(3), SHC3(12), SHC4(11), SOS1(12), SOS2(19), SYK(11), TNF(3), TNFRSF10A(3), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(3), TNFSF10(10), TYROBP(4), ULBP1(6), ULBP2(1), ULBP3(1), VAV1(21), VAV2(14), VAV3(16), ZAP70(16)	94339572	951	305	900	256	255	125	105	234	229	3	0.000134	1.000	1.000
163	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(26), ADCY8(48), ARAF(16), ATF4(4), BRAF(22), CACNA1C(58), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), CREBBP(59), EP300(39), GNAQ(4), GRIA1(31), GRIA2(34), GRIN1(11), GRIN2A(23), GRIN2B(31), GRIN2C(13), GRIN2D(12), GRM1(52), HRAS(2), ITPR1(40), ITPR2(41), ITPR3(46), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), NRAS(5), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PPP1CA(3), PPP1CB(1), PPP1CC(4), PPP1R12A(4), PPP1R1A(3), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKACA(9), PRKACB(6), PRKACG(9), PRKCA(9), PRKCG(19), PRKX(6), RAF1(11), RAP1A(4), RAP1B(6), RAPGEF3(5), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6)	82870428	922	305	888	287	269	122	116	224	185	6	0.0197	1.000	1.000
164	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(6), ACVR1B(17), ACVRL1(10), AKT1(7), AURKB(6), BMPR1A(13), BMPR2(24), BUB1(15), CDIPT(1), CDKL2(6), CDS1(6), CDS2(4), CLK1(6), CLK2(15), CLK4(8), COL4A3BP(6), CSNK2A1(6), CSNK2A2(9), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKQ(5), DGKZ(12), IMPA1(8), INPP1(4), INPP4A(12), INPP4B(15), INPP5A(11), INPPL1(29), ITPKA(2), ITPKB(20), MAP3K10(17), MOS(11), NEK1(9), NEK3(5), OCRL(10), PAK4(11), PIK3C2A(20), PIK3C2B(25), PIK3C2G(18), PIK3CB(17), PIK3CG(25), PIM2(3), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCG1(27), PLCG2(22), PLK3(10), PRKACA(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCQ(18), PRKCZ(4), PRKD1(30), PRKG1(15), RAF1(11), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA4(13), RPS6KB1(6), STK11(11), TGFBR1(10), VRK1(3)	96033095	933	305	882	225	257	114	110	206	239	7	7.57e-05	1.000	1.000
165	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	80	ABL1(12), ABL2(17), AKT1(7), AKT2(11), AKT3(10), ARAF(16), AREG(2), BAD(4), BRAF(22), BTC(2), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CBL(11), CBLB(6), CBLC(10), CDKN1A(7), CDKN1B(1), CRK(2), CRKL(2), EGF(15), EGFR(24), EIF4EBP1(5), ELK1(6), ERBB3(49), EREG(3), GAB1(5), GRB2(4), GSK3B(9), HBEGF(2), HRAS(2), JUN(6), MAP2K1(9), MAP2K2(6), MAP2K4(12), MAPK1(4), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(7), MYC(6), NCK1(7), NCK2(10), NRAS(5), NRG1(24), NRG2(11), NRG3(32), NRG4(2), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG1(27), PLCG2(22), PRKCA(9), PRKCG(19), PTK2(12), RAF1(11), RPS6KB1(6), RPS6KB2(9), SHC1(7), SHC2(3), SHC3(12), SHC4(11), SOS1(12), SOS2(19), SRC(5), STAT5A(13), STAT5B(15), TGFA(4)	81491448	856	294	812	235	256	120	94	189	193	4	0.00101	1.000	1.000
166	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(3), ALG1(9), ALG10B(11), ALG11(9), ALG12(13), ALG13(9), ALG14(3), ALG2(3), ALG3(4), ALG6(6), ALG8(3), ALG9(3), B3GNT1(8), B3GNT2(6), B3GNT6(6), B3GNT7(7), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT4(7), B4GALT5(5), B4GALT7(9), C1GALT1(4), C1GALT1C1(6), CHPF(8), CHST1(21), CHST11(4), CHST12(7), CHST13(6), CHST14(3), CHST2(15), CHST3(10), CHST4(7), CHST6(13), CHST7(8), CHSY1(12), DDOST(1), DPAGT1(6), EXT1(26), EXT2(8), EXTL1(8), EXTL2(2), EXTL3(15), FUT11(4), FUT8(11), GALNT1(4), GALNT10(10), GALNT11(7), GALNT12(6), GALNT13(14), GALNT14(15), GALNT2(9), GALNT3(6), GALNT4(6), GALNT5(14), GALNT6(7), GALNT7(4), GALNT8(12), GALNT9(6), GALNTL5(5), GANAB(21), GCNT1(4), GCNT3(5), GCNT4(8), HS2ST1(4), HS3ST1(10), HS3ST2(12), HS3ST3A1(5), HS3ST3B1(5), HS3ST5(10), HS6ST1(9), HS6ST2(11), HS6ST3(9), MAN1A1(6), MAN1A2(7), MAN1B1(8), MAN1C1(11), MAN2A1(10), MGAT1(6), MGAT2(4), MGAT3(13), MGAT4A(6), MGAT4B(6), MGAT5(14), MGAT5B(15), NDST1(18), NDST2(18), NDST3(23), NDST4(23), OGT(10), RPN1(7), RPN2(9), ST3GAL1(7), ST3GAL2(11), ST3GAL3(3), ST3GAL4(8), ST6GAL1(1), ST6GALNAC1(7), STT3B(10), UST(10), WBSCR17(37), XYLT1(14)	92681235	908	292	863	326	285	108	101	231	180	3	0.851	1.000	1.000
167	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(6), ACVR1B(17), ACVR1C(7), ACVR2A(11), ACVR2B(6), ACVRL1(10), AMHR2(11), BMP2(8), BMP4(6), BMP5(12), BMP6(14), BMP7(9), BMP8A(1), BMP8B(5), BMPR1A(13), BMPR1B(13), BMPR2(24), CDKN2B(1), CHRD(15), COMP(8), CREBBP(59), CUL1(28), DCN(16), E2F4(2), E2F5(5), EP300(39), FST(6), GDF5(15), GDF6(20), GDF7(5), ID1(2), ID2(1), ID3(2), ID4(1), IFNG(3), INHBA(19), INHBB(13), INHBC(8), INHBE(6), LEFTY1(3), LEFTY2(4), LTBP1(32), MAPK1(4), MAPK3(3), MYC(6), NODAL(2), NOG(3), PITX2(6), PPP2CA(5), PPP2CB(4), PPP2R1A(18), PPP2R1B(10), PPP2R2A(10), PPP2R2B(9), PPP2R2C(7), RBL1(14), RBL2(11), RBX1(1), ROCK1(22), ROCK2(20), RPS6KB1(6), RPS6KB2(9), SMAD1(4), SMAD2(11), SMAD3(9), SMAD5(2), SMAD6(8), SMAD7(7), SMAD9(15), SMURF1(9), SMURF2(7), SP1(6), TFDP1(6), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), THBS1(19), THBS2(24), THBS3(13), THBS4(18), TNF(3), ZFYVE16(17), ZFYVE9(14)	82656257	882	290	841	259	251	106	112	180	228	5	0.0184	1.000	1.000
168	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(7), AKT2(11), AKT3(10), BCL10(3), CARD11(32), CBL(11), CBLB(6), CBLC(10), CD247(4), CD28(2), CD3E(3), CD4(11), CD40LG(6), CD8A(4), CD8B(2), CDC42(3), CDK4(2), CHUK(10), CTLA4(4), FOS(2), FYN(10), GRAP2(9), GRB2(4), HRAS(2), ICOS(4), IFNG(3), IKBKB(12), IL10(4), IL4(4), ITK(12), JUN(6), LAT(3), LCK(5), LCP2(14), MALT1(4), MAP3K8(2), NCK1(7), NCK2(10), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(5), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PDCD1(6), PDK1(3), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKCQ(18), PTPN6(6), PTPRC(30), RASGRP1(11), SOS1(12), SOS2(19), TEC(5), TNF(3), VAV1(21), VAV2(14), VAV3(16), ZAP70(16)	84789073	820	290	777	233	233	106	94	199	185	3	0.0118	1.000	1.000
169	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(28), BDKRB1(4), BDKRB2(3), C1QA(5), C1QB(3), C1QC(5), C1R(1), C1S(11), C2(4), C3(43), C3AR1(13), C4BPA(6), C4BPB(4), C5(15), C5AR1(7), C6(19), C7(11), C8A(13), C8B(14), C9(10), CD46(8), CD55(4), CD59(1), CFB(8), CFH(37), CFI(15), CPB2(11), CR1(35), CR2(29), F10(10), F11(9), F12(5), F13A1(20), F13B(20), F2(15), F2R(10), F3(2), F5(26), F7(12), F8(36), F9(10), FGA(16), FGB(9), FGG(6), KLKB1(7), KNG1(13), MASP1(7), MASP2(6), MBL2(8), PLAT(8), PLAUR(6), PLG(21), PROC(5), PROS1(16), SERPINA1(9), SERPINA5(9), SERPINC1(5), SERPIND1(5), SERPINE1(3), SERPINF2(10), SERPING1(10), TFPI(7), THBD(5), VWF(47)	77928104	780	289	742	196	188	100	101	205	185	1	0.000369	1.000	1.000
170	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	77	ABL1(12), ATM(71), BUB1(15), BUB1B(16), BUB3(4), CCNA1(13), CCNA2(2), CCNB1(4), CCNB2(1), CCNB3(24), CCND2(2), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDAN1(17), CDC14A(21), CDC14B(8), CDC20(10), CDC25A(8), CDC25B(8), CDC25C(11), CDC6(13), CDC7(8), CDK2(5), CDK4(2), CDKN1A(7), CHEK1(7), CHEK2(13), DTX4(14), E2F1(6), E2F3(4), E2F4(2), E2F5(5), E2F6(1), EP300(39), ESPL1(29), GSK3B(9), HDAC1(10), HDAC2(6), HDAC3(10), HDAC4(41), HDAC5(15), HDAC6(12), HDAC8(3), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(15), MCM3(8), MCM4(17), MCM5(11), MCM6(13), MCM7(8), MDM2(10), MPEG1(12), MPL(7), PCNA(2), PLK1(18), PRKDC(70), PTPRA(19), PTTG1(2), RB1(22), RBL1(14), SKP2(6), TBC1D8(16), TFDP1(6), TGFB1(3), WEE1(7)	90687309	822	287	771	203	203	100	110	187	216	6	0.000889	1.000	1.000
171	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(11), CD14(2), CD19(5), CD1B(10), CD1D(15), CD1E(17), CD2(5), CD22(10), CD33(11), CD34(6), CD36(7), CD37(2), CD38(7), CD3E(3), CD4(11), CD44(8), CD5(6), CD55(4), CD59(1), CD7(6), CD8A(4), CD8B(2), CD9(2), CR1(35), CR2(29), CSF1(6), CSF1R(26), CSF2RA(12), CSF3(3), CSF3R(18), DNTT(6), EPO(3), EPOR(5), FCER2(5), FCGR1A(4), FLT3(21), FLT3LG(2), GP5(15), GP9(3), HLA-DRA(7), HLA-DRB1(2), HLA-DRB5(3), IL11(3), IL11RA(3), IL1A(2), IL1B(7), IL1R1(5), IL1R2(13), IL2RA(3), IL3(3), IL3RA(6), IL4(4), IL4R(10), IL5RA(12), IL6(1), IL6R(4), IL7(2), IL7R(18), IL9R(5), ITGA1(10), ITGA2(18), ITGA2B(15), ITGA3(14), ITGA4(21), ITGA5(11), ITGA6(17), ITGAM(13), ITGB3(8), KIT(20), KITLG(6), MME(14), MS4A1(2), TFRC(4), THPO(8), TNF(3), TPO(35)	69338786	680	282	634	180	154	87	85	181	170	3	0.00305	1.000	1.000
172	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(9), ALG6(6), CCKBR(19), CCR2(6), CCR3(14), CCR5(5), CELSR1(51), CELSR2(51), CELSR3(65), CHRM2(27), CHRM3(17), CIDEB(2), CXCR3(3), DRD4(6), EDNRA(5), EMR2(12), EMR3(7), F2R(10), FSHR(30), GHRHR(6), GNRHR(5), GPR116(19), GPR132(6), GPR133(19), GPR135(11), GPR143(4), GPR17(7), GPR18(4), GPR55(10), GPR56(13), GPR61(9), GPR84(6), GPR88(1), GRM1(52), GRPR(7), HRH4(10), LGR6(20), LPHN2(32), LTB4R2(6), NTSR1(11), OR2M4(10), P2RY11(5), P2RY13(7), PTGFR(6), SMO(19), SSTR2(4), TAAR5(7), TSHR(15), VN1R1(7)	54888908	683	273	652	189	209	88	86	190	108	2	0.000135	1.000	1.000
173	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(10), BAD(4), BCL2(4), CABIN1(28), CALM1(2), CALM2(3), CALM3(2), CAMK2B(9), CAMK4(10), CD3E(3), CD69(4), CDKN1A(7), CNR1(16), CREBBP(59), CSNK2A1(6), CTLA4(4), EGR2(9), EGR3(9), EP300(39), FCER1A(5), FCGR3A(6), FOS(2), FOSL1(3), GATA3(23), GATA4(4), GSK3A(6), GSK3B(9), HRAS(2), ICOS(4), IFNA1(1), IFNB1(4), IFNG(3), IL10(4), IL13(4), IL1B(7), IL2RA(3), IL3(3), IL4(4), IL6(1), ITK(12), JUNB(5), KPNA5(9), MAPK14(3), MAPK8(7), MAPK9(7), MEF2A(3), MEF2B(6), MEF2D(11), MYF5(6), NCK2(10), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB2(11), NFKBIB(8), NFKBIE(1), NPPB(3), NUP214(31), OPRD1(5), P2RX7(4), PAK1(7), PIN1(2), PPP3CB(8), PPP3CC(9), PPP3R1(3), PTPRC(30), RELA(7), RPL13A(5), SFN(1), SLA(9), SP1(6), SP3(7), TGFB1(3), TNF(3), TRAF2(5), TRPV6(12), VAV1(21), VAV2(14), VAV3(16), XPO5(6)	77987832	738	268	704	218	198	104	88	183	163	2	0.0124	1.000	1.000
174	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(45), ASH2L(5), CARM1(10), CTCFL(16), DOT1L(23), EED(9), EHMT1(24), EHMT2(23), EZH1(10), EZH2(6), FBXO11(16), HCFC1(23), HSF4(10), JMJD4(4), JMJD6(5), KDM6A(22), MEN1(11), NSD1(41), OGT(10), PAXIP1(17), PPP1CA(3), PPP1CB(1), PPP1CC(4), PRDM2(40), PRDM7(4), PRDM9(33), PRMT1(5), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), RBBP5(7), SATB1(20), SETD1A(29), SETD1B(3), SETD2(27), SETD7(3), SETD8(3), SETDB1(20), SETDB2(17), SETMAR(4), SMYD3(3), STK38(8), SUV39H1(6), SUV39H2(2), SUV420H1(23), SUV420H2(9), SUZ12(4), WHSC1(30), WHSC1L1(23)	103841678	688	263	661	170	176	82	84	166	171	9	0.00503	1.000	1.000
175	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(4), BRAF(22), CEBPA(2), CHUK(10), CREB1(4), DAXX(14), ELK1(6), FOS(2), GRB2(4), HRAS(2), IKBKB(12), JUN(6), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K5(3), MAP2K6(1), MAP3K1(24), MAP3K10(17), MAP3K11(12), MAP3K12(17), MAP3K13(14), MAP3K2(9), MAP3K3(10), MAP3K4(32), MAP3K5(18), MAP3K6(14), MAP3K7(14), MAP3K8(2), MAP3K9(7), MAP4K1(4), MAP4K2(14), MAP4K3(8), MAP4K4(16), MAP4K5(10), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK4(10), MAPK6(6), MAPK7(9), MAPK8(7), MAPK9(7), MAPKAPK2(4), MAPKAPK3(5), MAPKAPK5(6), MAX(4), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), MKNK1(6), MKNK2(10), MYC(6), NFKB1(10), NFKBIA(1), PAK1(7), PAK2(13), RAC1(2), RAF1(11), RELA(7), RIPK1(5), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KA4(13), RPS6KA5(9), RPS6KB1(6), RPS6KB2(9), SHC1(7), SP1(6), STAT1(14), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TRADD(2), TRAF2(5)	82215865	693	255	662	194	184	91	74	154	186	4	0.0318	1.000	1.000
176	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(4), AKT1(7), AKT2(11), AKT3(10), APAF1(11), ATM(71), BAD(4), BAX(3), BCL2(4), BCL2L1(2), BID(3), BIRC2(8), BIRC3(12), CAPN1(8), CAPN2(11), CASP10(8), CASP3(2), CASP6(2), CASP7(5), CASP9(4), CFLAR(3), CHUK(10), CSF2RB(18), DFFA(5), DFFB(5), ENDOG(2), FADD(4), FAS(3), FASLG(6), IKBKB(12), IL1A(2), IL1B(7), IL1R1(5), IL1RAP(8), IL3(3), IL3RA(6), IRAK1(9), IRAK2(11), IRAK3(10), IRAK4(4), MYD88(4), NFKB1(10), NFKB2(11), NFKBIA(1), NTRK1(14), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKACA(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RELA(7), RIPK1(5), TNF(3), TNFRSF10A(3), TNFRSF10B(3), TNFRSF10C(4), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(10), TRADD(2), TRAF2(5)	68515715	621	247	588	155	161	85	61	135	172	7	0.00123	1.000	1.000
177	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(8), BMP4(6), BMP5(12), BMP6(14), BMP7(9), BMP8A(1), BMP8B(5), BTRC(12), CSNK1A1(7), CSNK1A1L(8), CSNK1D(5), CSNK1E(10), CSNK1G1(7), CSNK1G2(8), CSNK1G3(10), DHH(2), FBXW11(9), GAS1(6), GLI1(28), GLI2(23), GLI3(69), GSK3B(9), HHIP(24), IHH(9), LRP2(81), PRKACA(9), PRKACB(6), PRKACG(9), PRKX(6), PTCH1(42), PTCH2(17), RAB23(2), SHH(6), SMO(19), STK36(12), SUFU(8), WNT10A(6), WNT10B(3), WNT11(3), WNT2(6), WNT2B(14), WNT3(6), WNT3A(9), WNT4(2), WNT5A(8), WNT5B(6), WNT6(4), WNT7A(6), WNT7B(10), WNT8A(2), WNT8B(2), WNT9A(9), WNT9B(6), ZIC2(10)	51026041	630	244	594	186	211	82	65	134	132	6	0.0150	1.000	1.000
178	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(5), AKT1(7), BDKRB2(3), CALM1(2), CALM2(3), CALM3(2), CAV1(6), CHRM1(8), CHRNA1(11), FLT1(26), FLT4(36), KDR(22), NOS3(20), PDE2A(19), PDE3A(26), PDE3B(26), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKG1(15), PRKG2(20), RYR2(141), SLC7A1(11), SYT1(8), TNNI1(1)	35135897	462	241	433	147	125	58	55	124	99	1	0.165	1.000	1.000
179	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(49), ACSL1(6), ACSL3(10), ACSL4(7), ACSL5(8), ACSL6(10), ADIPOQ(5), ADIPOR1(7), ADIPOR2(6), AGRP(2), AKT1(7), AKT2(11), AKT3(10), CAMKK1(5), CAMKK2(6), CD36(7), CHUK(10), CPT1A(16), CPT1B(13), CPT1C(12), CPT2(8), G6PC2(1), IKBKB(12), IRS1(33), IRS2(13), IRS4(28), JAK1(22), JAK2(14), JAK3(18), LEP(3), LEPR(18), MAPK10(7), MAPK8(7), MAPK9(7), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NPY(2), PCK1(14), PCK2(12), POMC(11), PPARA(8), PPARGC1A(16), PRKAA1(9), PRKAA2(11), PRKAB2(6), PRKAG1(6), PRKAG2(8), PRKAG3(8), PRKCQ(18), PTPN11(10), RELA(7), RXRA(13), RXRB(5), RXRG(7), SLC2A1(9), SLC2A4(5), SOCS3(4), STAT3(9), STK11(11), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF2(5), TYK2(15)	70925186	673	240	649	203	198	87	69	152	159	8	0.0617	1.000	1.000
180	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	94	AKT1(7), AKT2(11), AKT3(10), CCL3(1), CCL5(4), CD14(2), CD40(3), CD80(6), CD86(8), CHUK(10), CXCL10(1), CXCL9(2), FADD(4), FOS(2), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNAR1(9), IFNAR2(4), IFNB1(4), IKBKB(12), IKBKE(14), IL12A(3), IL12B(3), IL1B(7), IL6(1), IRAK1(9), IRAK4(4), IRF3(3), IRF5(7), IRF7(4), JUN(6), LBP(3), LY96(5), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K7(14), MAP3K8(2), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(7), MYD88(4), NFKB1(10), NFKB2(11), NFKBIA(1), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), RAC1(2), RELA(7), RIPK1(5), SPP1(4), STAT1(14), TBK1(8), TICAM1(9), TIRAP(1), TLR1(10), TLR2(9), TLR3(7), TLR5(11), TLR6(6), TLR7(7), TLR8(15), TLR9(15), TNF(3), TOLLIP(7), TRAF3(8), TRAF6(7)	71843819	597	238	574	186	154	77	79	136	148	3	0.129	1.000	1.000
181	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(7), AKT2(11), AKT3(10), BCL10(3), BLNK(8), BTK(5), CARD11(32), CD19(5), CD22(10), CD72(1), CD79A(10), CD79B(3), CD81(7), CHUK(10), CR2(29), FCGR2B(4), FOS(2), GSK3B(9), HRAS(2), IFITM1(5), IKBKB(12), INPP5D(12), JUN(6), LILRB3(7), LYN(9), MALT1(4), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(5), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLCG2(22), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PTPN6(6), RAC1(2), RAC2(2), RAC3(4), RASGRP3(8), SYK(11), VAV1(21), VAV2(14), VAV3(16)	61786772	615	238	576	170	182	82	73	130	145	3	0.00461	1.000	1.000
182	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(7), AKT2(11), AKT3(10), BAD(4), BCL2(4), BCR(18), BLNK(8), BTK(5), CD19(5), CD22(10), CD81(7), CR2(29), CSK(10), DAG1(14), FLOT2(14), GRB2(4), GSK3A(6), GSK3B(9), INPP5D(12), ITPR1(40), ITPR2(41), ITPR3(46), LYN(9), MAP4K1(4), MAPK1(4), MAPK3(3), NFATC1(20), NFATC2(32), NR0B2(4), PDK1(3), PIK3CD(20), PIK3R1(17), PLCG2(22), PPP1R13B(19), PPP3CA(14), PPP3CB(8), PPP3CC(9), PTPRC(30), RAF1(11), SHC1(7), SOS1(12), SOS2(19), SYK(11), VAV1(21)	61730608	613	238	579	178	187	72	58	150	141	5	0.0250	1.000	1.000
183	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(71), CCNA1(13), CCNB1(4), CCND1(3), CCND2(2), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(8), CDK2(5), CDK4(2), CDKN1A(7), CDKN1B(1), CDKN2B(1), CDKN2C(2), CDKN2D(5), CREB3L1(7), CREB3L3(6), CREB3L4(4), E2F1(6), E2F3(4), E2F4(2), E2F5(5), E2F6(1), GBA2(7), MCM2(15), MCM3(8), MCM4(17), MCM5(11), MCM6(13), MCM7(8), MDM2(10), MNAT1(4), MYC(6), MYT1(26), NACA(26), PCNA(2), POLA2(6), POLE(42), POLE2(6), PRIM1(6), RB1(22), RBL1(14), RPA1(6), RPA2(4), RPA3(1), TFDP1(6), TFDP2(8), TNXB(82), WEE1(7)	64647214	537	236	515	141	148	70	59	121	135	4	0.00678	1.000	1.000
184	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(5), CDC40(12), CLK2(15), CLK3(14), CLK4(8), COL2A1(26), CPSF1(33), CPSF2(10), CPSF3(4), CPSF4(2), CSTF1(11), CSTF2(7), CSTF2T(14), CSTF3(10), DDIT3(5), DDX1(15), DDX20(4), DHX15(15), DHX16(10), DHX38(17), DHX8(24), DHX9(20), DICER1(16), DNAJC8(5), FUS(5), GIPC1(11), LSM7(1), METTL3(4), NCBP1(8), NCBP2(3), NONO(6), NUDT21(3), NXF1(5), PABPN1(5), PAPOLA(9), PHF5A(1), POLR2A(27), PPM1G(4), PRPF18(3), PRPF3(10), PRPF4(10), PRPF4B(15), PRPF8(23), PSKH1(8), PTBP1(13), PTBP2(4), RBM17(2), RBM5(11), RNGTT(5), RNMT(11), RNPS1(2), SF3A1(10), SF3A2(3), SF3A3(3), SF3B1(15), SF3B2(20), SF3B4(10), SNRPA(7), SNRPA1(5), SNRPB(2), SNRPB2(2), SNRPD1(2), SNRPD2(6), SNRPD3(4), SNRPE(2), SNRPF(1), SNRPG(1), SNRPN(14), SNURF(1), SPOP(6), SRPK1(11), SRPK2(10), SRRM1(17), SUPT5H(19), TXNL4A(1), U2AF1(5), U2AF2(16), XRN2(16)	91211851	720	236	689	165	207	97	98	132	184	2	0.000668	1.000	1.000
185	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(12), APH1A(2), CREBBP(59), CTBP1(5), CTBP2(10), DLL1(17), DLL3(9), DLL4(5), DTX1(21), DTX2(9), DTX3(7), DTX3L(4), DTX4(14), DVL1(8), DVL2(11), DVL3(17), EP300(39), HDAC1(10), HDAC2(6), HES1(2), JAG1(18), JAG2(21), LFNG(4), MAML1(8), MAML2(18), MAML3(13), MFNG(1), NCOR2(52), NCSTN(13), NOTCH1(51), NOTCH2(39), NOTCH3(39), NOTCH4(29), NUMB(8), NUMBL(8), PSEN1(7), PSEN2(4), PSENEN(2), PTCRA(2), RBPJ(8), RBPJL(15), RFNG(3), SNW1(8)	60244758	638	235	612	220	192	78	72	129	162	5	0.319	1.000	1.000
186	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(13), ADCY6(19), ADCY8(48), CACNA1A(47), CACNA1B(38), GNAS(54), GNAT3(5), GNB1(2), GNB3(2), GNG13(3), GRM4(22), ITPR3(46), KCNB1(17), PDE1A(10), PLCB2(9), PRKACA(9), PRKACB(6), PRKACG(9), PRKX(6), SCNN1A(6), SCNN1B(10), SCNN1G(11), TAS1R1(11), TAS1R2(18), TAS1R3(14), TAS2R1(4), TAS2R10(5), TAS2R13(6), TAS2R14(7), TAS2R16(8), TAS2R3(4), TAS2R38(6), TAS2R39(4), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(6), TAS2R43(3), TAS2R46(5), TAS2R5(2), TAS2R50(3), TAS2R60(6), TAS2R7(5), TAS2R8(5), TAS2R9(3), TRPM5(9)	49354363	536	235	509	187	183	63	60	132	97	1	0.408	1.000	1.000
187	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	53	APC(68), AXIN1(17), CCND1(3), CCND2(2), CCND3(1), CSNK1E(10), DVL1(8), DVL2(11), DVL3(17), FBXW2(4), FOSL1(3), FZD1(15), FZD10(22), FZD2(17), FZD3(13), FZD5(6), FZD6(13), FZD7(15), FZD8(14), FZD9(5), GSK3B(9), JUN(6), LDLR(15), MAPK10(7), MAPK9(7), MYC(6), PPP2R5C(10), PPP2R5E(5), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCI(8), PRKCQ(18), PRKCZ(4), PRKD1(30), RAC1(2), SFRP4(8), TCF7(9), WNT10A(6), WNT10B(3), WNT11(3), WNT2(6), WNT2B(14), WNT3(6), WNT4(2), WNT5A(8), WNT5B(6), WNT6(4), WNT7A(6), WNT7B(10)	47962684	547	235	521	182	184	52	53	120	130	8	0.154	1.000	1.000
188	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(7), AKT2(11), AKT3(10), BAD(4), CASP9(4), CDC42(3), HRAS(2), KDR(22), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPKAPK2(4), MAPKAPK3(5), NFAT5(17), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NOS3(20), NRAS(5), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCG1(27), PLCG2(22), PPP3CA(14), PPP3CB(8), PPP3CC(9), PPP3R1(3), PRKCA(9), PRKCG(19), PTGS2(7), PTK2(12), PXN(9), RAC1(2), RAC2(2), RAC3(4), RAF1(11), SH2D2A(8), SHC2(3), SPHK1(10), SPHK2(11), SRC(5)	59619644	588	234	560	144	196	83	64	123	121	1	8.93e-06	1.000	1.000
189	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	AKT1(7), AKT2(11), AKT3(10), BTK(5), FCER1A(5), FYN(10), GRB2(4), HRAS(2), IL13(4), IL3(3), IL4(4), INPP5D(12), LAT(3), LCP2(14), LYN(9), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(7), MS4A2(3), NRAS(5), PDK1(3), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCG1(27), PLCG2(22), PRKCA(9), PRKCD(12), PRKCE(16), RAC1(2), RAC2(2), RAC3(4), RAF1(11), SOS1(12), SOS2(19), SYK(11), TNF(3), VAV1(21), VAV2(14), VAV3(16)	57895582	560	233	540	150	164	75	68	134	117	2	0.00314	1.000	1.000
190	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(18), AMY2A(9), AMY2B(23), ENPP1(12), ENPP3(16), GAA(11), GANAB(21), GBE1(10), GCK(10), GPI(6), GUSB(12), GYS1(10), GYS2(11), HK1(18), HK2(15), HK3(13), MGAM(28), PGM1(4), PGM3(13), PYGB(17), PYGL(14), PYGM(18), RNPC3(5), SI(49), UCHL1(3), UCHL3(4), UGDH(11), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2B15(6), UGT2B4(6), UXS1(9)	49275365	453	230	426	138	100	57	58	138	99	1	0.262	1.000	1.000
191	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(2), ACTR3(3), AKT1(7), AKT2(11), AKT3(10), ANGPTL2(9), ARHGAP1(8), ARHGAP4(4), ARHGEF11(26), BTK(5), CDC42(3), CFL1(2), CFL2(1), GDI1(6), GDI2(7), INPPL1(29), ITPR1(40), ITPR2(41), ITPR3(46), LIMK1(7), MYLK(31), MYLK2(9), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PDK1(3), PIK3CD(20), PIK3CG(25), PIK3R1(17), PITX2(6), PPP1R13B(19), RACGAP1(9), RHO(10), ROCK1(22), ROCK2(20), RPS4X(2), SAG(5), WASF1(11), WASL(7)	57868017	552	228	523	153	162	65	72	114	130	9	0.0205	1.000	1.000
192	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(7), AKT2(11), AKT3(10), BAD(4), BCL2L1(2), CDC42(3), CDK2(5), CDKN1B(1), CREB1(4), CREB5(9), EBP(2), F2RL2(5), GAB1(5), GRB2(4), GSK3A(6), GSK3B(9), IFI27(3), IGF1(3), IGFBP1(11), INPPL1(29), IRS1(33), IRS2(13), IRS4(28), MET(14), MYC(6), NOLC1(16), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PARD3(24), PARD6A(1), PDK1(3), PIK3CD(20), PPP1R13B(19), PREX1(26), PTK2(12), PTPN1(8), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SLC2A4(5), SOS1(12), SOS2(19), TSC1(20), TSC2(21), YWHAB(3), YWHAE(5), YWHAG(4), YWHAH(3), YWHAQ(5), YWHAZ(4)	61057836	569	228	544	152	165	72	61	115	153	3	0.00590	1.000	1.000
193	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(7), AK3(7), CAD(31), CANT1(5), CTPS2(3), DCK(5), DCTD(2), DHODH(7), DPYD(25), DPYS(12), DTYMK(2), DUT(3), ENTPD1(6), ENTPD3(6), ENTPD4(14), ENTPD5(5), ENTPD6(7), ENTPD8(7), ITPA(1), NME2(3), NME4(2), NME6(4), NME7(4), NT5C1A(9), NT5C1B(14), NT5C2(9), NT5E(5), NT5M(7), NUDT2(5), PNPT1(6), POLA1(8), POLA2(6), POLD1(18), POLD2(8), POLD3(7), POLE(42), POLE2(6), POLE3(4), POLE4(1), POLR1A(23), POLR1B(11), POLR1C(9), POLR1D(4), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLR3A(31), POLR3B(16), POLR3G(3), POLR3H(2), POLR3K(2), PRIM1(6), PRIM2(10), RFC5(3), RRM1(5), RRM2(3), RRM2B(5), TK1(1), TK2(4), TXNRD1(13), TXNRD2(6), TYMS(3), UCK1(7), UCK2(2), UMPS(6), UPB1(6), UPP1(4), UPP2(8), UPRT(6), ZNRD1(2)	70044240	583	225	563	169	171	68	77	134	133	0	0.0357	1.000	1.000
194	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(6), ADAM17(12), ATP6AP1(6), ATP6V0A1(9), ATP6V0A2(11), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V0D2(6), ATP6V0E1(1), ATP6V1A(7), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), CASP3(2), CCL5(4), CDC42(3), CHUK(10), CSK(10), CXCL1(1), EGFR(24), F11R(2), GIT1(4), HBEGF(2), IGSF5(5), IKBKB(12), JAM2(2), JAM3(7), JUN(6), LYN(9), MAP2K4(12), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK8(7), MAPK9(7), MET(14), NFKB1(10), NFKB2(11), NFKBIA(1), NOD1(17), PAK1(7), PLCG1(27), PLCG2(22), PTPN11(10), PTPRZ1(40), RAC1(2), RELA(7), SRC(5), TCIRG1(7), TJP1(32)	59605130	501	225	490	146	117	75	55	133	119	2	0.0873	1.000	1.000
195	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR1(1), AGTR2(6), ATP8A1(18), AVPR1A(20), AVPR1B(3), AVPR2(12), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(13), CCKAR(8), CCKBR(19), CCR1(8), CCR10(4), CCR2(6), CCR3(14), CCR4(3), CCR5(5), CCR6(2), CCR7(5), CCR8(4), CX3CR1(7), CXCR3(3), CXCR4(1), CXCR6(2), EDNRA(5), FPR1(9), FSHR(30), GALR1(8), GALR2(14), GALR3(5), GALT(3), GHSR(10), GNB2L1(5), GNRHR(5), GRPR(7), MC1R(8), MC2R(4), MC3R(12), MC4R(11), MC5R(6), NMBR(3), NPY1R(6), NPY2R(8), NPY5R(5), NTSR1(11), NTSR2(7), OPRD1(5), OPRK1(19), OPRL1(11), OPRM1(9), OXTR(9), SSTR1(12), SSTR2(4), SSTR3(11), SSTR4(18), TAC4(4), TACR1(4), TACR2(2), TACR3(18), TRHR(7), TSHR(15)	42535029	504	218	481	203	175	57	78	116	77	1	0.580	1.000	1.000
196	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(6), IMPA1(8), IMPA2(2), INPP1(4), INPP4A(12), INPP4B(15), INPP5A(11), INPP5B(12), INPP5E(11), INPPL1(29), IPMK(2), ISYNA1(5), ITPK1(7), ITPKA(2), ITPKB(20), MINPP1(6), MIOX(8), OCRL(10), PI4KA(29), PI4KB(11), PIK3C3(17), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIP4K2A(9), PIP4K2B(9), PIP4K2C(2), PIP5K1A(4), PIP5K1B(2), PIP5K1C(15), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCD3(11), PLCD4(8), PLCE1(27), PLCG1(27), PLCG2(22), PLCZ1(14), PTPMT1(2), SYNJ1(18), SYNJ2(24)	61538646	566	217	538	150	178	79	59	127	119	4	0.00189	1.000	1.000
197	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(11), ATM(71), ATR(33), BAI1(26), BAX(3), BID(3), CASP3(2), CASP9(4), CCNB1(4), CCNB2(1), CCNB3(24), CCND1(3), CCND2(2), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CD82(3), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CHEK1(7), CHEK2(13), DDB2(3), EI24(2), FAS(3), GADD45B(3), GTSE1(7), IGF1(3), IGFBP3(7), MDM2(10), MDM4(5), PERP(5), PMAIP1(1), PPM1D(11), RCHY1(4), RFWD2(9), RPRM(6), RRM2(3), RRM2B(5), SERPINB5(5), SERPINE1(3), SESN1(2), SESN2(5), SESN3(6), SFN(1), SIAH1(3), STEAP3(13), THBS1(19), TNFRSF10B(3), TP53I3(1), TP73(9), TSC2(21), ZMAT3(4)	53505675	424	216	406	112	113	55	48	96	108	4	0.0140	1.000	1.000
198	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(11), CD28(2), CSK(10), CTLA4(4), DAG1(14), DTYMK(2), EPHB2(19), GRAP2(9), GRB2(4), ITK(12), ITPKA(2), ITPKB(20), LAT(3), LCK(5), LCP2(14), MAPK1(4), NCK1(7), NFAT5(17), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PLCG1(27), PTPRC(30), RAF1(11), RASGRP1(11), RASGRP2(9), RASGRP3(8), RASGRP4(8), SOS1(12), SOS2(19), VAV1(21), ZAP70(16)	46993786	436	215	419	131	127	45	43	125	94	2	0.243	1.000	1.000
199	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(7), APOA1(9), CD36(7), CITED2(6), CPT1B(13), CREBBP(59), DUSP1(3), DUT(3), EHHADH(5), EP300(39), HSD17B4(11), HSPA1A(4), JUN(6), LPL(11), MAPK1(4), MAPK3(3), ME1(2), MRPL11(1), MYC(6), NCOA1(27), NCOR1(34), NCOR2(52), NFKBIA(1), NR0B2(4), NR1H3(5), NR2F1(11), NRIP1(21), PDGFA(4), PIK3R1(17), PPARA(8), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), PTGS2(7), RB1(22), RELA(7), RXRA(13), SP1(6), STAT5A(13), STAT5B(15), TNF(3)	52518291	522	213	502	150	130	66	57	112	152	5	0.0809	1.000	1.000
200	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(22), CPEB1(7), EGFR(24), ETS1(9), ETS2(4), ETV6(9), ETV7(6), FMN2(64), GRB2(4), MAP2K1(9), MAPK1(4), MAPK3(3), NOTCH1(51), NOTCH2(39), NOTCH3(39), NOTCH4(29), PIWIL1(10), PIWIL2(13), PIWIL3(7), PIWIL4(9), RAF1(11), SOS1(12), SOS2(19), SPIRE1(11), SPIRE2(9)	40461536	424	212	403	141	113	56	41	115	96	3	0.538	1.000	1.000
201	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(5), AGT(5), AKT1(7), CALM1(2), CALM2(3), CALM3(2), CALR(4), CAMK1(4), CAMK1G(10), CAMK4(10), CREBBP(59), CSNK1A1(7), EDN1(4), ELSPBP1(3), F2(15), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(9), HAND1(5), HAND2(7), HRAS(2), IGF1(3), LIF(4), MAP2K1(9), MAPK1(4), MAPK14(3), MAPK3(3), MAPK8(7), MEF2C(7), MYH2(49), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NKX2-5(10), NPPA(2), PIK3R1(17), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RAF1(11), RPS6KB1(6), SYT1(8)	41582900	468	212	443	134	147	55	53	92	120	1	0.0120	1.000	1.000
202	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(2), APAF1(11), ARHGDIB(1), BAG4(5), BCL2(4), BID(3), BIRC2(8), BIRC3(12), CASP2(5), CASP3(2), CASP6(2), CASP7(5), CASP9(4), CFLAR(3), CHUK(10), CRADD(7), DAXX(14), DFFA(5), DFFB(5), FADD(4), GSN(15), LMNA(13), LMNB1(5), LMNB2(11), MAP3K1(24), MAP3K5(18), MAPK8(7), MDM2(10), NFKB1(10), NFKBIA(1), NUMA1(31), PAK2(13), PRKCD(12), PRKDC(70), PSEN1(7), PSEN2(4), PTK2(12), RASA1(28), RB1(22), RELA(7), RIPK1(5), SPTAN1(30), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF1(6), TRAF2(5)	58123198	493	209	472	148	122	64	71	96	136	4	0.260	1.000	1.000
203	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), AOC2(14), AOC3(18), AOX1(18), CARM1(10), COMT(5), DBH(8), DCT(20), DDC(14), ECH1(5), ESCO1(13), ESCO2(11), FAH(9), GOT1(3), GOT2(2), GSTZ1(2), HEMK1(2), HGD(8), HPD(4), LCMT1(2), LCMT2(11), MAOA(6), MAOB(6), METTL2B(1), METTL6(5), MIF(2), NAT6(4), PNMT(11), PNPLA3(4), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), SH3GLB1(5), TAT(7), TH(10), TPO(35), TYR(18), TYRP1(10), WBSCR22(5)	51096131	432	206	402	113	107	46	40	107	128	4	0.0500	1.000	1.000
204	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(7), APC(68), AR(29), ASAH1(4), BRAF(22), CAMP(3), CCL13(1), CCL15(2), CCL16(3), DAG1(14), EGFR(24), GNA11(6), GNA15(6), GNAI1(4), GNAQ(4), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), KCNJ3(18), KCNJ5(8), KCNJ9(5), MAPK1(4), MAPK10(7), MAPK14(3), PHKA2(18), PIK3CD(20), PIK3R1(17), PITX2(6), PTX3(4), RAF1(11), SRC(5)	43905961	472	205	448	155	129	50	66	112	107	8	0.370	1.000	1.000
205	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(7), ALPL(10), ALPP(16), ALPPL2(6), ASCC3(41), ATP13A2(20), DDX18(17), DDX19A(8), DDX23(15), DDX4(12), DDX41(11), DDX47(2), DDX50(14), DDX51(11), DDX52(8), DDX54(18), DDX55(7), DDX56(11), DHX58(12), ENTPD7(11), EP400(55), ERCC2(11), ERCC3(9), FPGS(8), GCH1(1), GGH(2), IFIH1(13), MOV10L1(13), NUDT5(1), NUDT8(2), QDPR(6), RAD54B(5), RAD54L(5), RUVBL2(10), SETX(31), SKIV2L2(18), SMARCA2(39), SMARCA5(12), SPR(3)	54223988	501	204	484	156	145	56	59	122	117	2	0.319	1.000	1.000
206	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(7), AKT2(11), AKT3(10), ANKRD6(11), APC(68), AXIN1(17), AXIN2(22), CER1(4), CSNK1A1(7), DACT1(12), DKK1(12), DKK2(11), DKK3(5), DKK4(7), DVL1(8), FSTL1(6), GSK3A(6), GSK3B(9), LRP1(62), MVP(14), NKD1(8), NKD2(7), PIN1(2), PSEN1(7), PTPRA(19), SENP2(10), SFRP1(9), TSHB(5), WIF1(5)	33404372	381	202	356	108	108	43	46	79	96	9	0.106	1.000	1.000
207	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(8), ACADM(7), ACOX1(7), ACOX2(10), ACOX3(14), ACSL1(6), ACSL3(10), ACSL4(7), ACSL5(8), ACSL6(10), ADIPOQ(5), ANGPTL4(5), APOA1(9), APOA5(9), APOC3(3), AQP7(9), CD36(7), CPT1A(16), CPT1B(13), CPT1C(12), CPT2(8), CYP27A1(8), CYP4A11(4), CYP4A22(7), CYP7A1(7), CYP8B1(7), DBI(1), EHHADH(5), FABP2(1), FABP3(1), FABP4(2), FABP5(2), FABP6(5), FABP7(1), FADS2(6), GK(5), GK2(13), HMGCS2(6), ILK(11), LPL(11), ME1(2), MMP1(4), NR1H3(5), OLR1(4), PCK1(14), PCK2(12), PDPK1(1), PLTP(8), PPARA(8), PPARD(8), PPARG(6), RXRA(13), RXRB(5), RXRG(7), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(10), SLC27A4(11), SLC27A5(6), SLC27A6(17), SORBS1(19), UBC(9), UCP1(5)	56233780	477	199	461	149	151	62	55	110	99	0	0.144	1.000	1.000
208	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(7), AKT2(11), AKT3(10), BRAF(22), CAB39(2), EIF4B(5), EIF4EBP1(5), FIGF(5), HIF1A(10), IGF1(3), MAPK1(4), MAPK3(3), PDPK1(1), PGF(4), PIK3CB(17), PIK3CD(20), PIK3CG(25), PIK3R1(17), PIK3R2(16), PIK3R3(10), PIK3R5(15), PRKAA1(9), PRKAA2(11), RHEB(3), RICTOR(31), RPS6(1), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), RPS6KB2(9), STK11(11), TSC1(20), TSC2(21), ULK1(23), ULK2(13), ULK3(5), VEGFB(2), VEGFC(17)	42746749	423	199	401	122	126	47	61	83	102	4	0.131	1.000	1.000
209	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(7), AKT2(11), AKT3(10), ASAH1(4), BRAF(22), DAG1(14), DRD2(14), EGFR(24), EPHB2(19), GRB2(4), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), KCNJ3(18), KCNJ5(8), KCNJ9(5), MAPK1(4), PI3(2), PIK3CB(17), PITX2(6), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), RAF1(11), RGS20(9), SHC1(7), SOS1(12), SOS2(19), SRC(5), STAT3(9), TERF2IP(6)	50405232	492	199	470	163	153	73	54	111	97	4	0.305	1.000	1.000
210	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), AGK(6), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AGPAT6(7), AKR1A1(6), AKR1B1(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), CEL(20), DAK(8), DGAT1(10), DGAT2(2), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKI(27), DGKQ(5), DGKZ(12), GK(5), GK2(13), GLA(3), GLB1(9), GPAM(12), LCT(32), LIPA(3), LIPC(5), LIPF(10), LIPG(5), LPL(11), MGLL(3), PNLIP(6), PNLIPRP1(5), PNPLA3(4), PPAP2A(5), PPAP2B(5), PPAP2C(6)	50605726	447	198	421	138	121	50	56	106	112	2	0.212	1.000	1.000
211	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(7), AKT2(11), AKT3(10), BCR(18), BTK(5), CD19(5), DAPP1(2), FLOT2(14), GAB1(5), ITPR1(40), ITPR2(41), ITPR3(46), LYN(9), NR0B2(4), PDK1(3), PHF11(5), PITX2(6), PLCG2(22), PPP1R13B(19), PREX1(26), PTPRC(30), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), SAG(5), SYK(11), TEC(5), VAV1(21)	44737759	405	195	391	128	129	48	40	103	82	3	0.186	1.000	1.000
212	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(18), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AGPAT6(7), CDIPT(1), CDS1(6), CDS2(4), CHAT(14), CHKA(2), CHKB(4), CHPT1(4), CRLS1(1), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKI(27), DGKQ(5), DGKZ(12), ESCO1(13), ESCO2(11), ETNK1(5), ETNK2(4), GNPAT(5), GPAM(12), GPD1(8), GPD1L(4), GPD2(10), LCAT(5), LYPLA1(2), LYPLA2(2), NAT6(4), PCYT1A(11), PCYT1B(9), PEMT(1), PHOSPHO1(1), PISD(6), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLD1(26), PLD2(22), PNPLA3(4), PPAP2A(5), PPAP2B(5), PPAP2C(6), PTDSS1(8), PTDSS2(3), SH3GLB1(5)	56209647	440	194	426	121	136	45	55	96	106	2	0.0221	1.000	1.000
213	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(7), AKT2(11), AKT3(10), BRD4(23), CAP1(2), CBL(11), CDC42(3), F2RL2(5), FLOT2(14), GRB2(4), GSK3A(6), GSK3B(9), IGFBP1(11), INPPL1(29), IRS1(33), IRS2(13), IRS4(28), LNPEP(15), MAPK1(4), MAPK3(3), PARD3(24), PARD6A(1), PDK1(3), PIK3CD(20), PIK3R1(17), PTPN1(8), RAF1(11), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), SERPINB6(5), SFN(1), SHC1(7), SLC2A4(5), SORBS1(19), SOS1(12), SOS2(19), YWHAB(3), YWHAE(5), YWHAG(4), YWHAH(3), YWHAQ(5), YWHAZ(4)	47904062	452	194	430	128	140	61	41	84	123	3	0.0685	1.000	1.000
214	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(12), ACTR2(2), ACTR3(3), AKT1(7), ANGPTL2(9), CDC42(3), CFL1(2), CFL2(1), FLNA(31), FLNC(48), FSCN1(7), FSCN2(2), FSCN3(15), GDI1(6), GDI2(7), LIMK1(7), MYH2(49), MYLK(31), MYLK2(9), PAK1(7), PAK2(13), PAK3(8), PAK4(11), PAK6(15), PAK7(15), PFN1(1), PFN2(1), RHO(10), ROCK1(22), ROCK2(20), RPS4X(2), VASP(2), WASF1(11), WASL(7)	41319111	398	194	391	134	129	45	55	85	80	4	0.209	1.000	1.000
215	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(25), AR(29), ESR1(14), ESR2(10), ESRRA(4), HNF4A(10), NPM1(3), NR0B1(6), NR1D1(11), NR1D2(11), NR1H2(7), NR1H3(5), NR1I2(11), NR1I3(3), NR2C2(10), NR2E1(4), NR2F1(11), NR2F2(6), NR2F6(6), NR3C1(10), NR4A1(6), NR4A2(18), NR5A1(9), NR5A2(10), PGR(23), PPARA(8), PPARD(8), PPARG(6), RARA(4), RARB(11), RARG(3), ROR1(13), RORA(9), RORC(7), RXRA(13), RXRB(5), RXRG(7), THRA(13), THRB(5), VDR(6)	36010843	380	193	369	134	128	51	41	99	59	2	0.380	1.000	1.000
216	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(3), BAK1(5), BAX(3), BFAR(5), BTK(5), CAD(31), CASP10(8), CASP3(2), CD7(6), CDK2AP1(1), CSNK1A1(7), DAXX(14), DEDD(4), DEDD2(4), DFFA(5), DIABLO(1), EGFR(24), EPHB2(19), FADD(4), FAF1(13), FAIM2(2), HSPB1(2), IL1A(2), MAP2K4(12), MAP3K1(24), MAP3K5(18), MAPK1(4), MAPK10(7), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), MET(14), NFAT5(17), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR0B2(4), PFN1(1), PFN2(1), PTPN13(41), RALBP1(12), RIPK1(5), ROCK1(22), SMPD1(8), TPX2(10), TRAF2(5)	60514197	454	193	436	152	120	63	53	94	119	5	0.492	1.000	1.000
217	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(18), ACSS2(20), ACYP1(2), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), AKR1A1(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH7A1(2), ALDH9A1(7), ALDOA(1), ALDOB(11), ALDOC(11), BPGM(5), DLAT(9), DLD(14), ENO1(4), ENO2(6), ENO3(4), FBP1(4), FBP2(8), G6PC2(1), GALM(4), GAPDH(5), GAPDHS(5), GCK(10), GPI(6), HK1(18), HK2(15), HK3(13), LDHA(7), LDHAL6A(4), LDHAL6B(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(16), PDHB(4), PFKL(9), PFKM(6), PFKP(23), PGAM1(1), PGAM2(5), PGAM4(2), PGK1(5), PGK2(4), PGM1(4), PGM3(13), PKLR(12), TPI1(3)	50158638	454	192	431	149	115	85	48	111	95	0	0.170	1.000	1.000
218	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(2), CALM2(3), CALM3(2), CD3E(3), ELK1(6), FOS(2), FYN(10), GRB2(4), HRAS(2), JUN(6), LAT(3), LCK(5), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK3(3), MAPK8(7), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB1(10), NFKBIA(1), PIK3R1(17), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKCA(9), PTPN7(8), RAC1(2), RAF1(11), RASA1(28), RELA(7), SHC1(7), SOS1(12), SYT1(8), VAV1(21), ZAP70(16)	39216120	397	192	375	87	118	49	35	83	109	3	0.000102	1.000	1.000
219	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(9), AASDHPPT(1), AASS(13), ACAT1(9), ACAT2(6), AKR1B10(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), BBOX1(6), DLST(6), DOT1L(23), ECHS1(3), EHHADH(5), EHMT1(24), EHMT2(23), GCDH(8), HADH(3), HADHA(7), HSD17B4(11), HSD3B7(9), NSD1(41), OGDH(13), OGDHL(25), PIPOX(4), PLOD1(12), PLOD2(18), PLOD3(21), RDH11(1), RDH12(3), RDH13(8), SETD1A(29), SETD7(3), SETDB1(20), SHMT1(4), SHMT2(13), SPCS1(2), SPCS3(3), SUV39H1(6), SUV39H2(2), TMLHE(6)	49781362	474	191	439	135	135	59	55	103	120	2	0.0598	1.000	1.000
220	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(36), ACACB(49), ACAT1(9), ACAT2(6), ACOT12(9), ACSS1(18), ACSS2(20), ACYP1(2), ACYP2(3), AKR1B1(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), DLAT(9), DLD(14), GLO1(3), GRHPR(4), HAGH(6), HAGHL(2), LDHA(7), LDHAL6A(4), LDHAL6B(7), LDHB(5), LDHC(1), LDHD(2), MDH1(5), MDH2(2), ME1(2), ME2(10), ME3(8), PC(19), PCK1(14), PCK2(12), PDHA1(1), PDHA2(16), PDHB(4), PKLR(12)	40085121	395	191	373	117	102	70	41	88	93	1	0.104	1.000	1.000
221	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(7), ASAH1(4), BRAF(22), CAMP(3), CREB1(4), CREB5(9), CREBBP(59), CRKL(2), DAG1(14), EGR1(14), EGR2(9), EGR3(9), EGR4(8), ELK1(6), FRS2(6), GNAQ(4), JUN(6), MAP1B(38), MAP2K4(12), MAPK1(4), MAPK10(7), MAPK3(3), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), NTRK1(14), OPN1LW(10), PIK3C2G(18), PIK3CD(20), PIK3R1(17), PTPN11(10), RPS6KA3(6), SHC1(7), SRC(5), TERF2IP(6), TH(10)	41713512	416	191	396	136	116	52	46	91	109	2	0.298	1.000	1.000
222	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(11), BAD(4), BAK1(5), BAX(3), BCL2(4), BCL2L1(2), BCL2L11(7), BID(3), BIRC2(8), BIRC3(12), BIRC5(3), BNIP3L(1), CASP1(8), CASP10(8), CASP2(5), CASP3(2), CASP4(7), CASP6(2), CASP7(5), CASP9(4), CHUK(10), DFFA(5), DFFB(5), FADD(4), FAS(3), FASLG(6), GZMB(2), HELLS(9), IKBKB(12), IRF1(6), IRF3(3), IRF4(12), IRF5(7), IRF6(9), IRF7(4), JUN(6), LTA(4), MAP2K4(12), MAP3K1(24), MAPK10(7), MDM2(10), MYC(6), NFKB1(10), NFKBIA(1), NFKBIB(8), NFKBIE(1), PLEKHG5(13), PRF1(17), RELA(7), RIPK1(5), TNF(3), TNFRSF10B(3), TNFRSF1A(6), TNFRSF1B(4), TNFRSF21(6), TNFRSF25(9), TNFSF10(10), TP73(9), TRADD(2), TRAF1(6), TRAF2(5), TRAF3(8)	46966416	403	190	385	113	103	55	49	89	104	3	0.0333	1.000	1.000
223	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(10), AKT1(7), APC(68), ASAH1(4), CAMP(3), CAV3(2), DAG1(14), DLG4(8), EPHB2(19), GNAI1(4), GNAQ(4), ITPR1(40), ITPR2(41), ITPR3(46), KCNJ3(18), KCNJ5(8), KCNJ9(5), MAPK1(4), PITX2(6), PTX3(4), RAC1(2), RHO(10), RYR1(81)	39451534	408	190	394	131	133	47	48	88	85	7	0.106	1.000	1.000
224	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(9), AANAT(2), ACAT1(9), ACAT2(6), ACMSD(6), AFMID(5), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), AOC2(14), AOC3(18), AOX1(18), ASMT(9), CARM1(10), CAT(6), CYP1A1(10), CYP1A2(6), CYP1B1(4), DDC(14), ECHS1(3), EHHADH(5), GCDH(8), HAAO(1), HADH(3), HADHA(7), HEMK1(2), HSD17B4(11), INMT(4), KMO(7), KYNU(15), LCMT1(2), LCMT2(11), LNX1(7), MAOA(6), MAOB(6), METTL2B(1), METTL6(5), NFX1(8), OGDH(13), OGDHL(25), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), TDO2(10), TPH1(6), TPH2(12), WARS(5), WARS2(14), WBSCR22(5)	52132677	463	189	425	121	106	66	48	100	140	3	0.0276	1.000	1.000
225	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(7), CAD(31), CANT1(5), CTPS2(3), DCK(5), DCTD(2), DHODH(7), DPYD(25), DPYS(12), DTYMK(2), DUT(3), ENTPD1(6), ITPA(1), NME2(3), NT5E(5), NT5M(7), NUDT2(5), POLB(8), POLD1(18), POLD2(8), POLE(42), POLG(10), POLL(4), POLQ(46), POLR1B(11), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLRMT(17), RRM1(5), RRM2(3), TK1(1), TK2(4), TXNRD1(13), TYMS(3), UCK1(7), UCK2(2), UMPS(6), UNG(2), UPB1(6), UPP1(4)	49474757	408	189	394	137	105	58	55	93	97	0	0.472	1.000	1.000
226	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(7), AKT2(11), AKT3(10), BAD(4), BCR(18), BLNK(8), BTK(5), CD19(5), CSK(10), DAG1(14), EPHB2(19), GRB2(4), ITPKA(2), ITPKB(20), LYN(9), MAP2K1(9), MAP2K2(6), MAPK1(4), NFAT5(17), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PI3(2), PIK3CD(20), PIK3R1(17), PLCG2(22), PPP1R13B(19), RAF1(11), SERPINA4(9), SHC1(7), SOS1(12), SOS2(19), SYK(11), VAV1(21)	43688910	388	188	367	120	117	46	34	97	92	2	0.243	1.000	1.000
227	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT1(9), ACAT2(6), ACMSD(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), AOC2(14), AOC3(18), AOX1(18), ASMT(9), CAT(6), CYP19A1(13), CYP1A1(10), CYP1A2(6), CYP2A13(15), CYP2A6(8), CYP2A7(9), CYP2B6(9), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2D6(15), CYP2E1(8), CYP2F1(13), CYP2J2(5), CYP3A4(3), CYP3A5(3), CYP3A7(5), CYP4B1(12), CYP51A1(13), DDC(14), ECHS1(3), EHHADH(5), GCDH(8), HAAO(1), HADHA(7), KMO(7), KYNU(15), MAOA(6), MAOB(6), SDS(5), TDO2(10), TPH1(6), WARS(5), WARS2(14)	47532073	455	188	421	112	118	57	40	108	130	2	0.00972	1.000	1.000
228	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(5), ACTN1(8), ACTN2(34), BCAR1(16), BCR(18), CAPN1(8), CAPNS1(6), CAPNS2(3), CAV1(6), CRKL(2), CSK(10), FYN(10), GRB2(4), HRAS(2), ITGA1(10), ITGB1(12), JUN(6), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MAPK8(7), PPP1R12B(17), PTK2(12), PXN(9), RAF1(11), RAP1A(4), ROCK1(22), SHC1(7), SOS1(12), SRC(5), TLN1(35), VCL(19), ZYX(8)	40801788	350	186	334	105	129	41	34	87	57	2	0.0393	1.000	1.000
229	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(65), B3GALT4(9), CDR1(7), DGKI(27), IL6ST(11), MRPL19(3), PIGK(5), RPL10(6), RPL11(3), RPL12(3), RPL13(1), RPL13A(5), RPL14(2), RPL15(1), RPL17(1), RPL18(1), RPL18A(2), RPL19(1), RPL22(9), RPL23(2), RPL24(2), RPL26(2), RPL27(1), RPL28(2), RPL29(2), RPL3(5), RPL30(1), RPL31(3), RPL32(1), RPL34(2), RPL35(1), RPL35A(1), RPL36(2), RPL37(1), RPL38(2), RPL3L(4), RPL4(3), RPL5(3), RPL6(4), RPL7A(8), RPL8(5), RPL9(4), RPLP0(5), RPLP1(2), RPLP2(2), RPS10(2), RPS11(3), RPS13(4), RPS14(3), RPS15(2), RPS16(1), RPS18(1), RPS19(3), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(2), RPS26(3), RPS27(1), RPS27A(4), RPS3(2), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(5), RPS6(1), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), RPS6KB2(9), RPS7(1), RPS9(3), RPSA(5), SLC36A2(7), TBC1D10C(10), TSPAN9(4), UBA52(2), UBB(2), UBC(9)	44115146	368	186	355	121	93	41	47	96	90	1	0.893	1.000	1.000
230	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(22), CARM1(10), CCND1(3), CREBBP(59), EP300(39), ERCC3(9), ESR1(14), GRIP1(24), GTF2A1(3), GTF2E1(7), GTF2F1(11), HDAC1(10), HDAC2(6), HDAC3(10), HDAC4(41), HDAC5(15), HDAC6(12), MEF2C(7), NCOR2(52), NR0B1(6), NRIP1(21), PELP1(11), POLR2A(27), TBP(8)	39703292	427	185	404	105	125	56	45	96	101	4	0.000841	1.000	1.000
231	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(6), B3GALNT1(5), B3GALT1(3), B3GALT2(10), B3GALT4(9), B3GALT5(2), B3GNT1(8), B3GNT2(6), B3GNT3(3), B3GNT4(9), B3GNT5(12), B4GALNT1(7), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT4(7), B4GALT6(9), FUT1(6), FUT2(2), FUT3(6), FUT4(3), FUT5(4), FUT6(8), FUT7(4), FUT9(11), GBGT1(4), GCNT2(1), PIGA(3), PIGB(11), PIGC(6), PIGG(16), PIGK(5), PIGL(5), PIGM(4), PIGN(12), PIGO(13), PIGP(1), PIGQ(14), PIGS(8), PIGT(15), PIGV(7), PIGX(3), PIGZ(11), ST3GAL1(7), ST3GAL2(11), ST3GAL3(3), ST3GAL4(8), ST3GAL5(3), ST3GAL6(7), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(11), ST6GALNAC6(5), ST8SIA1(12), ST8SIA5(8), UGCG(4)	41755154	387	185	363	129	114	40	42	98	92	1	0.623	1.000	1.000
232	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(35), COL4A2(24), COL4A3(19), COL4A4(25), COL4A5(26), COL4A6(15), F10(10), F11(9), F12(5), F2(15), F2R(10), F5(26), F8(36), F9(10), FGA(16), FGB(9), FGG(6), KLKB1(7), PROC(5), PROS1(16), SERPINC1(5), SERPING1(10)	38254445	339	185	332	92	74	56	39	100	68	2	0.0253	1.000	1.000
233	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(5), CALM1(2), CALM2(3), CALM3(2), ELK1(6), FCER1A(5), FOS(2), GRB2(4), HRAS(2), JUN(6), LYN(9), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK1(4), MAPK3(3), MAPK8(7), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), PAK2(13), PIK3R1(17), PLA2G4A(8), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), RAF1(11), SHC1(7), SOS1(12), SYK(11), SYT1(8), VAV1(21)	34452847	350	184	332	68	103	46	37	72	89	3	4.50e-06	1.000	1.000
234	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(17), ATP4A(24), ATP4B(5), ATP5A1(5), ATP5B(10), ATP5C1(7), ATP5F1(5), ATP5G2(2), ATP5G3(2), ATP5H(1), ATP5J(3), ATP5J2(1), ATP5L(1), ATP6AP1(6), ATP6V0A1(9), ATP6V0A2(11), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V0D2(6), ATP6V0E1(1), ATP6V1A(7), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), COX10(2), COX15(5), COX4I1(4), COX4I2(3), COX5A(1), COX5B(1), COX6B1(2), COX6B2(1), COX6C(1), COX7A1(2), COX7B(3), COX7C(1), COX8A(1), COX8C(5), CYC1(5), LHPP(4), NDUFA1(2), NDUFA10(4), NDUFA12(2), NDUFA13(3), NDUFA3(1), NDUFA4(1), NDUFA7(1), NDUFA8(6), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(2), NDUFB11(2), NDUFB2(1), NDUFB3(3), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFB8(4), NDUFB9(2), NDUFC2(3), NDUFS1(8), NDUFS2(8), NDUFS3(4), NDUFS4(3), NDUFS5(3), NDUFS6(4), NDUFS7(4), NDUFS8(3), NDUFV1(6), NDUFV2(2), NDUFV3(2), PPA1(5), PPA2(4), SDHA(15), SDHB(4), SDHC(2), SDHD(3), TCIRG1(7), UQCRB(2), UQCRC1(3), UQCRC2(9), UQCRFS1(4), UQCRQ(2)	47282487	407	183	399	121	115	64	49	90	89	0	0.0483	1.000	1.000
235	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(7), AKT2(11), AKT3(10), ARHGEF11(26), BCL2(4), CDC42(3), DLG4(8), GNA13(10), LPA(31), MAP2K4(12), MAP3K1(24), MAP3K5(18), MAPK8(7), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(18), PI3(2), PIK3CB(17), PLD1(26), PLD2(22), PLD3(9), PTK2(12), RDX(13), ROCK1(22), ROCK2(20), SERPINA4(9), SRF(5), TBXA2R(11)	42447796	396	183	375	95	101	58	48	70	114	5	0.00467	1.000	1.000
236	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), ACTR3(3), AKT1(7), ANGPTL2(9), DAG1(14), DGKA(12), ETFA(3), GCA(3), ITGA9(11), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), MAP2K1(9), MAPK1(4), MAPK3(3), NR1I3(3), PAK1(7), PDE3A(26), PDE3B(26), PI3(2), PIK3C2G(18), PIK3CD(20), PIK3R1(17), PSME1(4), RIPK3(5), RPS4X(2), SGCB(6), VASP(2)	40033620	367	182	353	122	99	46	49	87	82	4	0.295	1.000	1.000
237	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	29	ACVR1(6), APC(68), ATF2(4), AXIN1(17), BMP10(7), BMP2(8), BMP4(6), BMP5(12), BMP7(9), BMPR1A(13), BMPR2(24), CHRD(15), DVL1(8), FZD1(15), GATA4(4), GSK3B(9), MAP3K7(14), MEF2C(7), MYL2(9), NKX2-5(10), NOG(3), NPPA(2), NPPB(3), RFC1(19), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TGFBR3(12)	28391841	338	181	320	97	80	30	38	72	110	8	0.287	1.000	1.000
238	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(26), ADRA1B(6), ADRA1D(9), ADRA2A(12), ADRA2C(6), ADRB1(10), ADRB2(9), ADRB3(6), CHRM1(8), CHRM2(27), CHRM3(17), CHRM4(7), CHRM5(5), DRD1(7), DRD2(14), DRD3(9), DRD4(6), DRD5(13), HRH1(7), HRH2(9), HTR1A(18), HTR1B(11), HTR1D(9), HTR1E(18), HTR1F(10), HTR2A(12), HTR2B(5), HTR2C(11), HTR4(5), HTR5A(14), HTR6(7), HTR7(17)	21986477	350	180	330	117	127	41	47	94	41	0	0.0250	1.000	1.000
239	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(19), EEF1A2(8), EEF1B2(4), EEF1D(3), EEF1G(5), EEF2(22), EEF2K(15), EIF1AX(2), EIF1AY(2), EIF2AK1(7), EIF2AK2(6), EIF2AK3(22), EIF2B1(8), EIF2B2(5), EIF2B3(9), EIF2B4(12), EIF2B5(11), EIF2S1(3), EIF2S2(3), EIF2S3(3), EIF4A1(4), EIF4A2(8), EIF4E(2), EIF4EBP1(5), EIF4EBP2(7), EIF4G1(31), EIF4G3(26), EIF5(6), EIF5A(5), EIF5B(34), ETF1(7), GSPT2(9), PABPC1(12), PABPC3(20), PAIP1(4), SLC35A4(9)	37835112	358	179	337	74	80	47	52	88	88	3	0.000298	1.000	1.000
240	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(5), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH4A1(8), ALDH9A1(7), AMD1(8), AOC2(14), AOC3(18), ARG1(3), ARG2(4), ASL(8), CKB(7), CKM(2), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(35), DAO(15), GAMT(2), GATM(5), GLUD1(5), GOT1(3), GOT2(2), MAOA(6), MAOB(6), NOS1(45), NOS3(20), OAT(6), ODC1(4), OTC(5), P4HA1(6), P4HA2(11), P4HA3(7), P4HB(5), PYCR1(3), RARS(9), SMS(6)	38087168	380	178	355	99	103	40	48	93	96	0	0.0297	1.000	1.000
241	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(71), ATR(33), BRCA1(22), CCNB1(4), CDC25A(8), CDC25B(8), CDC25C(11), CDC34(2), CDKN1A(7), CDKN2D(5), CHEK1(7), CHEK2(13), EP300(39), MDM2(10), MYT1(26), PRKDC(70), RPS6KA1(10), WEE1(7), YWHAH(3), YWHAQ(5)	35687592	361	178	343	83	77	45	49	90	95	5	0.0115	1.000	1.000
242	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), AKR1A1(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH9A1(7), ALDOA(1), ALDOB(11), ALDOC(11), BPGM(5), DLAT(9), DLD(14), ENO1(4), ENO2(6), ENO3(4), FBP1(4), FBP2(8), GAPDH(5), GCK(10), GPI(6), HK1(18), HK2(15), HK3(13), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(16), PDHB(4), PFKM(6), PFKP(23), PGAM1(1), PGK1(5), PGM1(4), PGM3(13), PKLR(12), TPI1(3)	42083253	388	178	367	125	97	62	42	100	87	0	0.243	1.000	1.000
243	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(18), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AGPS(10), CDIPT(1), CDS1(6), CDS2(4), CHAT(14), CHKA(2), CHKB(4), CLC(2), CPT1B(13), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKQ(5), DGKZ(12), ETNK1(5), GNPAT(5), GPD1(8), GPD2(10), LCAT(5), LYPLA1(2), LYPLA2(2), PAFAH2(5), PCYT1A(11), PCYT1B(9), PEMT(1), PISD(6), PLA2G2A(2), PLA2G2E(4), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLCB2(9), PLCG1(27), PLCG2(22), PPAP2A(5), PPAP2B(5), PPAP2C(6)	42198197	362	178	351	107	125	38	49	79	69	2	0.0491	1.000	1.000
244	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), AKR1A1(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH9A1(7), ALDOA(1), ALDOB(11), ALDOC(11), BPGM(5), DLAT(9), DLD(14), ENO1(4), ENO2(6), ENO3(4), FBP1(4), FBP2(8), GAPDH(5), GCK(10), GPI(6), HK1(18), HK2(15), HK3(13), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(16), PDHB(4), PFKM(6), PFKP(23), PGAM1(1), PGK1(5), PGM1(4), PGM3(13), PKLR(12), TPI1(3)	42083253	388	178	367	125	97	62	42	100	87	0	0.243	1.000	1.000
245	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(71), BMPR1B(13), CCND2(2), CDK4(2), CDKN1B(1), DMC1(10), EGR1(14), ESR2(10), FSHR(30), GJA4(8), INHA(7), MLH1(10), MSH5(6), NCOR1(34), NR5A1(9), NRIP1(21), PGR(23), PRLR(8), PTGER2(8), SMPD1(8), VDR(6), ZP2(13)	28828372	314	178	298	68	68	46	38	79	78	5	0.00119	1.000	1.000
246	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AKR1A1(6), AKR1B1(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), CEL(20), DGAT1(10), DGKA(12), DGKB(14), DGKD(8), DGKE(8), DGKG(8), DGKH(19), DGKQ(5), DGKZ(12), GK(5), GLA(3), GLB1(9), LCT(32), LIPC(5), LIPF(10), LIPG(5), LPL(11), PNLIP(6), PNLIPRP1(5), PPAP2A(5), PPAP2B(5), PPAP2C(6)	41603781	375	177	352	120	103	38	48	87	97	2	0.370	1.000	1.000
247	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(26), CALM1(2), CALM2(3), CALM3(2), CREB1(4), ELK1(6), FOS(2), GNAI1(4), GNAQ(4), GNAS(54), GNB1(2), GNGT1(4), HRAS(2), JUN(6), MAP2K1(9), MAPK3(3), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), RAF1(11), RPS6KA3(6), SYT1(8)	30034645	348	177	326	86	131	46	29	66	75	1	0.000770	1.000	1.000
248	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(7), ATF2(4), CDC42(3), DLD(14), DUSP10(11), DUSP4(3), DUSP8(2), GAB1(5), GCK(10), IL1R1(5), JUN(6), MAP2K4(12), MAP2K5(3), MAP3K1(24), MAP3K10(17), MAP3K11(12), MAP3K12(17), MAP3K13(14), MAP3K2(9), MAP3K3(10), MAP3K4(32), MAP3K5(18), MAP3K7(14), MAP3K9(7), MAPK10(7), MAPK7(9), MAPK8(7), MAPK9(7), MYEF2(10), NFATC3(7), NR2C2(10), PAPPA(35), SHC1(7), TRAF6(7), ZAK(12)	41936154	377	177	361	103	96	56	40	87	97	1	0.0652	1.000	1.000
249	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(5), AGXT2(13), AKR1B10(6), ALAS1(5), ALAS2(16), AMT(5), AOC2(14), AOC3(18), BHMT(8), CBS(9), CHDH(7), CHKA(2), CHKB(4), CTH(3), DAO(15), DLD(14), DMGDH(8), GAMT(2), GARS(6), GATM(5), GCAT(5), GLDC(11), GNMT(4), HSD3B7(9), MAOA(6), MAOB(6), PEMT(1), PHGDH(6), PIPOX(4), PISD(6), PSAT1(10), PSPH(4), RDH11(1), RDH12(3), RDH13(8), SARDH(14), SARS(11), SARS2(10), SDS(5), SHMT1(4), SHMT2(13), TARS(17), TARS2(15)	37006284	338	174	327	99	97	44	43	79	74	1	0.0824	1.000	1.000
250	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	70	CALR(4), CANX(4), CD4(11), CD74(5), CD8A(4), CD8B(2), CIITA(23), CREB1(4), CTSB(3), CTSS(5), HLA-C(11), HLA-DMA(1), HLA-DMB(7), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(3), HLA-DPB1(5), HLA-DQA2(7), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(2), HLA-DRB5(3), HLA-E(7), HLA-F(8), HLA-G(7), HSP90AA1(15), HSP90AB1(13), HSPA5(4), IFI30(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), KIR2DL3(9), KIR3DL1(13), KIR3DL2(5), KLRC1(4), KLRC2(2), KLRC3(10), KLRC4(1), KLRD1(5), LGMN(7), LTA(4), NFYA(1), NFYB(3), NFYC(4), PDIA3(7), PSME1(4), PSME2(5), RFX5(17), RFXANK(7), RFXAP(4), TAP1(5), TAP2(11), TAPBP(8)	38701525	344	174	332	82	66	44	63	90	78	3	0.00370	1.000	1.000
251	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), AOC2(14), AOC3(18), AOX1(18), COMT(5), DBH(8), DCT(20), DDC(14), FAH(9), GOT1(3), GOT2(2), GSTZ1(2), HGD(8), HPD(4), MAOA(6), MAOB(6), PNMT(11), TAT(7), TH(10), TPO(35), TYR(18)	27369648	291	174	268	84	79	28	26	76	79	3	0.164	1.000	1.000
252	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(8), CASP3(2), CASP6(2), CASP7(5), CFLAR(3), DAXX(14), DFFA(5), DFFB(5), FADD(4), FAF1(13), JUN(6), LMNA(13), LMNB1(5), LMNB2(11), MAP2K4(12), MAP3K1(24), MAP3K7(14), MAPK8(7), PAK1(7), PAK2(13), PRKDC(70), PTPN13(41), RB1(22), RIPK2(3), SPTAN1(30)	34533153	340	173	326	96	67	37	52	71	111	2	0.333	1.000	1.000
253	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(10), AARS2(21), CARS(11), CARS2(9), DARS(2), DARS2(6), EARS2(4), EPRS(21), FARS2(9), FARSA(8), FARSB(4), GARS(6), HARS(10), HARS2(5), IARS(15), IARS2(13), KARS(9), LARS(13), LARS2(12), MARS(10), MARS2(6), MTFMT(3), NARS(5), NARS2(4), QARS(10), RARS(9), RARS2(7), SARS(11), SARS2(10), TARS(17), TARS2(15), VARS(25), VARS2(16), WARS(5), WARS2(14), YARS(9), YARS2(4)	46619115	368	172	357	99	99	43	55	95	75	1	0.0876	1.000	1.000
254	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(12), ADCY3(21), ADCY9(23), AK1(1), ARF1(6), ARF4(2), ARF5(1), ARF6(2), ARL4D(1), ATP6V0A1(9), ATP6V0A2(11), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V0D2(6), ATP6V0E1(1), ATP6V1A(7), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), ERO1L(2), GNAS(54), PDIA4(9), PLCG1(27), PLCG2(22), PRKCA(9), SEC61A1(7), SEC61A2(5), SEC61B(1), SEC61G(1), TRIM23(11)	31895157	334	172	313	81	124	39	35	76	60	0	0.00128	1.000	1.000
255	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(5), AGXT2(13), ALAS1(5), ALAS2(16), AMT(5), AOC2(14), AOC3(18), ATP6V0C(2), BHMT(8), CBS(9), CHDH(7), CHKA(2), CHKB(4), CPT1B(13), CTH(3), DAO(15), DLD(14), DMGDH(8), GAMT(2), GARS(6), GATM(5), GCAT(5), GLDC(11), MAOA(6), MAOB(6), PEMT(1), PISD(6), PLCB2(9), PLCG1(27), PLCG2(22), PSPH(4), SARDH(14), SARS(11), SHMT1(4), SHMT2(13), TARS(17)	36301077	330	171	318	95	96	41	38	79	76	0	0.0711	1.000	1.000
256	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(8), BTK(5), CALM1(2), CALM2(3), CALM3(2), CD79A(10), CD79B(3), ELK1(6), FOS(2), GRB2(4), HRAS(2), JUN(6), LYN(9), MAP2K1(9), MAP3K1(24), MAPK14(3), MAPK3(3), MAPK8(7), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKCA(9), RAC1(2), RAF1(11), SHC1(7), SOS1(12), SYK(11), SYT1(8), VAV1(21)	32820852	326	170	304	73	109	45	30	68	74	0	0.000169	1.000	1.000
257	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(3), ACAA2(13), ACADM(7), ACADS(6), ACAT1(9), ACAT2(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH6A1(8), ALDH7A1(2), ALDH9A1(7), AOX1(18), AUH(7), BCAT1(6), BCAT2(11), BCKDHA(14), BCKDHB(6), DBT(6), DLD(14), ECHS1(3), EHHADH(5), HADH(3), HADHA(7), HADHB(6), HIBADH(3), HIBCH(6), HMGCS1(2), HMGCS2(6), HSD17B4(11), IVD(5), MCCC1(5), MCCC2(10), MCEE(6), MUT(10), OXCT1(10), OXCT2(7), PCCA(15), PCCB(6)	37084522	332	170	306	82	69	54	35	72	101	1	0.0268	1.000	1.000
258	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	47	ABL1(12), ACTB(10), ACTG1(2), ARHGEF2(18), ARPC5(1), ARPC5L(3), CD14(2), CDC42(3), CLDN1(4), CTTN(13), EZR(6), FYN(10), HCLS1(4), ITGB1(12), KRT18(5), LY96(5), NCK1(7), NCK2(10), NCL(12), OCLN(10), PRKCA(9), ROCK1(22), ROCK2(20), TLR5(11), TUBA1A(5), TUBA1B(3), TUBA1C(4), TUBA3C(17), TUBA3D(12), TUBA3E(11), TUBA4A(3), TUBA8(11), TUBAL3(8), TUBB(1), TUBB1(9), TUBB2A(7), TUBB2B(5), TUBB3(12), TUBB6(9), TUBB8(10), WAS(4), WASL(7), YWHAQ(5), YWHAZ(4)	40670470	358	170	343	112	102	57	40	84	73	2	0.0778	1.000	1.000
259	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	47	ABL1(12), ACTB(10), ACTG1(2), ARHGEF2(18), ARPC5(1), ARPC5L(3), CD14(2), CDC42(3), CLDN1(4), CTTN(13), EZR(6), FYN(10), HCLS1(4), ITGB1(12), KRT18(5), LY96(5), NCK1(7), NCK2(10), NCL(12), OCLN(10), PRKCA(9), ROCK1(22), ROCK2(20), TLR5(11), TUBA1A(5), TUBA1B(3), TUBA1C(4), TUBA3C(17), TUBA3D(12), TUBA3E(11), TUBA4A(3), TUBA8(11), TUBAL3(8), TUBB(1), TUBB1(9), TUBB2A(7), TUBB2B(5), TUBB3(12), TUBB6(9), TUBB8(10), WAS(4), WASL(7), YWHAQ(5), YWHAZ(4)	40670470	358	170	343	112	102	57	40	84	73	2	0.0778	1.000	1.000
260	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(4), CEBPA(2), CHUK(10), DAXX(14), EGF(15), EGFR(24), ETS1(9), ETS2(4), FOS(2), HOXA7(4), HRAS(2), IKBKB(12), JUN(6), MAP2K1(9), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K1(24), MAP3K5(18), MAPK1(4), MAPK13(4), MAPK14(3), MAPK3(3), MAPK8(7), NFKB1(10), NFKBIA(1), PPP2CA(5), PRKCA(9), PRKCD(12), PRKCE(16), PRKCG(19), PRKCH(9), PRKCQ(18), RAF1(11), RELA(7), RIPK1(5), SP1(6), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRAF2(5)	41730887	350	170	335	115	104	52	41	75	76	2	0.133	1.000	1.000
261	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	12	CASR(22), GABBR1(20), GPRC5A(3), GPRC5B(17), GPRC5C(12), GPRC5D(2), GRM1(52), GRM2(30), GRM3(31), GRM4(22), GRM7(30), GRM8(38)	16070810	279	169	269	94	104	31	35	67	42	0	0.152	1.000	1.000
262	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(10), AARS2(21), ABAT(4), ACY3(3), ADSL(8), ADSS(6), ADSSL1(10), AGXT(5), AGXT2(13), ASL(8), ASNS(10), ASPA(4), ASRGL1(6), ASS1(11), CAD(31), CRAT(14), DARS(2), DARS2(6), DDO(7), DLAT(9), DLD(14), GAD1(11), GAD2(17), GOT1(3), GOT2(2), GPT(8), GPT2(4), NARS(5), NARS2(4), PC(19), PDHA1(1), PDHA2(16), PDHB(4)	32655189	296	169	281	89	89	40	35	66	65	1	0.165	1.000	1.000
263	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), AKR1C1(3), AKR1C2(2), AKR1C3(3), AKR1C4(7), ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), CYP1A1(10), CYP1A2(6), CYP1B1(4), CYP2B6(9), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2E1(8), CYP2F1(13), CYP2S1(9), CYP3A4(3), CYP3A43(6), CYP3A5(3), CYP3A7(5), DHDH(5), EPHX1(13), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(3), GSTK1(3), GSTM2(1), GSTM3(3), GSTM4(3), GSTM5(3), GSTO2(4), GSTP1(2), GSTZ1(2), MGST1(3), MGST2(3), MGST3(5), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7)	49316669	365	169	346	97	81	43	47	99	95	0	0.0715	1.000	1.000
264	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(8), INPP1(4), INPP4A(12), INPP4B(15), INPP5A(11), INPPL1(29), ITPKA(2), ITPKB(20), MIOX(8), OCRL(10), PIK3C2A(20), PIK3C2B(25), PIK3C2G(18), PIK3CB(17), PIK3CG(25), PLCB1(24), PLCB2(9), PLCB3(21), PLCB4(22), PLCD1(7), PLCG1(27), PLCG2(22)	36834995	356	169	334	87	102	51	45	77	79	2	0.0114	1.000	1.000
265	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(7), GTF2E2(4), GTF2F1(11), GTF2F2(3), GTF2H1(6), GTF2H3(4), GTF2H4(9), GTF2I(6), GTF2IRD1(19), STON1(10), TAF1(32), TAF10(2), TAF13(1), TAF1L(45), TAF2(15), TAF4(16), TAF4B(10), TAF5(4), TAF5L(12), TAF6(15), TAF6L(9), TAF7(8), TAF7L(10), TAF9B(5), TBPL1(4), TBPL2(7)	30995493	286	168	276	70	63	39	38	75	71	0	0.0407	1.000	1.000
266	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(5), CASP2(5), CASP3(2), CRADD(7), DFFA(5), DFFB(5), FADD(4), JUN(6), LMNA(13), LMNB1(5), LMNB2(11), MADD(25), MAP2K4(12), MAP3K1(24), MAP3K7(14), MAPK8(7), PAK1(7), PAK2(13), PRKDC(70), RB1(22), RIPK1(5), SPTAN1(30), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(5)	32636532	314	168	305	93	74	33	47	63	94	3	0.380	1.000	1.000
267	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(3), CALM3(2), CAMK1(4), CAMK1G(10), ELK1(6), FPR1(9), GNA15(6), GNB1(2), GNGT1(4), HRAS(2), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K6(1), MAP3K1(24), MAPK1(4), MAPK14(3), MAPK3(3), NCF1(4), NCF2(3), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), NFKB1(10), NFKBIA(1), PAK1(7), PIK3C2G(18), PLCB1(24), PPP3CA(14), PPP3CB(8), PPP3CC(9), RAC1(2), RAF1(11), RELA(7), SYT1(8)	33066035	316	167	300	95	93	44	36	65	78	0	0.0960	1.000	1.000
268	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(5), AGTR2(6), CALM1(2), CALM2(3), CALM3(2), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CDK5(3), F2(15), FYN(10), GNA11(6), GNAI1(4), GNB1(2), GNGT1(4), GRB2(4), HRAS(2), JAK2(14), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK14(3), MAPK3(3), MAPK8(7), MAPT(12), MYLK(31), PLCG1(27), PRKCA(9), PTK2B(20), RAF1(11), SHC1(7), SOS1(12), STAT1(14), STAT3(9), STAT5A(13), SYT1(8)	36054148	314	164	304	94	98	42	32	82	58	2	0.0857	1.000	1.000
269	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(10), F11(9), F12(5), F13B(20), F2(15), F5(26), F7(12), F8(36), F9(10), FGA(16), FGB(9), FGG(6), LPA(31), PLAT(8), PLG(21), SERPINB2(11), SERPINE1(3), SERPINF2(10), VWF(47)	30271253	305	164	296	78	75	35	40	86	68	1	0.0336	1.000	1.000
270	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACAA2(13), ACADL(8), ACADM(7), ACADS(6), ACADSB(9), ACADVL(5), ACAT1(9), ACAT2(6), ACOX1(7), ACOX3(14), ACSL1(6), ACSL3(10), ACSL4(7), ACSL5(8), ACSL6(10), ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), CPT1A(16), CPT1B(13), CPT1C(12), CPT2(8), CYP4A11(4), CYP4A22(7), ECHS1(3), EHHADH(5), GCDH(8), HADH(3), HADHA(7), HADHB(6), HSD17B4(11)	42069034	337	163	315	80	78	58	41	65	95	0	0.00179	1.000	1.000
271	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ALDH4A1(8), ALDH5A1(6), CAD(31), CPS1(35), EARS2(4), EPRS(21), GAD1(11), GAD2(17), GCLC(4), GCLM(4), GFPT1(9), GFPT2(9), GLS(13), GLS2(8), GLUD1(5), GLUD2(17), GLUL(7), GMPS(10), GNPNAT1(6), GOT1(3), GOT2(2), GPT(8), GPT2(4), GSR(8), GSS(2), NADSYN1(13), NAGK(2), PPAT(7), QARS(10)	34020030	288	163	279	86	68	38	39	81	62	0	0.186	1.000	1.000
272	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(11), BAD(4), BAX(3), BCL2(4), BCL2A1(1), BCL2L1(2), BCL2L2(5), BOK(2), CASP1(8), CASP10(8), CASP2(5), CASP3(2), CASP4(7), CASP6(2), CASP7(5), CASP9(4), CD40(3), CD40LG(6), CRADD(7), DAXX(14), DFFA(5), DFFB(5), FADD(4), FAS(3), FASLG(6), IKBKE(14), LTA(4), MCL1(3), NFKB1(10), NFKBIA(1), NGFR(9), NR3C1(10), NTRK1(14), PTPN13(41), RIPK1(5), TFG(2), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF1(6), TRAF2(5), TRAF3(8), TRAF6(7)	36445063	280	162	272	90	76	36	33	72	62	1	0.240	1.000	1.000
273	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(71), ATR(33), BRCA1(22), BRCA2(48), CHEK1(7), CHEK2(13), FANCA(17), FANCC(8), FANCD2(18), FANCE(6), FANCF(2), FANCG(5), HUS1(2), MRE11A(9), RAD1(2), RAD17(10), RAD50(15), RAD51(4), RAD9A(5), TREX1(5)	37073607	302	162	284	54	44	36	35	76	103	8	0.0107	1.000	1.000
274	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(24), ELK1(6), GNAS(54), GNB1(2), GNGT1(4), GRB2(4), HRAS(2), IGF1R(24), ITGB1(12), KLK2(2), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), MKNK1(6), MKNK2(10), MYC(6), NGFR(9), PDGFRA(17), PPP2CA(5), PTPRR(16), RAF1(11), RPS6KA1(10), RPS6KA5(9), SHC1(7), SOS1(12), SRC(5), STAT3(9)	28722458	288	162	269	110	104	40	27	75	41	1	0.705	1.000	1.000
275	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(15), AADAC(6), ABAT(4), ACADS(6), ACAT1(9), ACAT2(6), ACSM1(8), AKR1B10(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH5A1(6), ALDH7A1(2), ALDH9A1(7), BDH1(8), BDH2(4), DDHD1(17), ECHS1(3), EHHADH(5), GAD1(11), GAD2(17), HADH(3), HADHA(7), HMGCS1(2), HMGCS2(6), HSD17B4(11), HSD3B7(9), ILVBL(9), L2HGDH(5), OXCT1(10), OXCT2(7), PDHA1(1), PDHA2(16), PDHB(4), PLA1A(4), PPME1(2), PRDX6(5), RDH11(1), RDH12(3), RDH13(8)	34935927	312	162	291	97	81	48	30	72	81	0	0.201	1.000	1.000
276	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(3), ARHGAP1(8), ARHGAP4(4), ARHGAP5(34), ARHGAP6(14), ARHGEF1(15), ARHGEF11(26), ARHGEF5(8), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), BAIAP2(7), CFL1(2), DIAPH1(16), GSN(15), LIMK1(7), MYL2(9), MYLK(31), OPHN1(11), PFN1(1), PIP5K1A(4), PIP5K1B(2), PPP1R12B(17), ROCK1(22), SRC(5), TLN1(35), VCL(19)	39159206	328	162	313	91	98	45	42	63	74	6	0.0595	1.000	1.000
277	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(9), AASDH(15), AASDHPPT(1), AASS(13), ACAT1(9), ACAT2(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), ATP6V0C(2), BBOX1(6), DLST(6), DOT1L(23), ECHS1(3), EHHADH(5), EHMT1(24), EHMT2(23), GCDH(8), HADHA(7), PLOD1(12), PLOD2(18), PLOD3(21), SDS(5), SHMT1(4), SHMT2(13), TMLHE(6)	31776433	324	160	294	87	78	46	40	66	93	1	0.0306	1.000	1.000
278	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	19	APC(68), AXIN1(17), BTRC(12), CCND1(3), CREBBP(59), CSNK1A1(7), CSNK1D(5), CSNK2A1(6), CTBP1(5), DVL1(8), FZD1(15), GSK3B(9), HDAC1(10), MAP3K7(14), MYC(6), PPARD(8), PPP2CA(5), TLE1(15), WIF1(5)	22645026	277	160	255	69	74	32	26	45	94	6	0.0274	1.000	1.000
279	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(36), ACACB(49), ACADM(7), ACAT1(9), ACAT2(6), ACSS1(18), ACSS2(20), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH6A1(8), ALDH7A1(2), ALDH9A1(7), ECHS1(3), EHHADH(5), HADHA(7), HIBCH(6), LDHA(7), LDHAL6A(4), LDHAL6B(7), LDHB(5), LDHC(1), MCEE(6), MLYCD(8), MUT(10), PCCA(15), PCCB(6), SUCLA2(3), SUCLG1(4), SUCLG2(9)	34102097	331	158	305	71	77	56	34	77	86	1	0.00127	1.000	1.000
280	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(13), CDC7(8), CDK2(5), CDT1(6), DIAPH2(18), GMNN(2), MCM10(15), MCM2(15), MCM3(8), MCM4(17), MCM5(11), MCM6(13), MCM7(8), NACA(26), PCNA(2), POLA2(6), POLD1(18), POLD2(8), POLD3(7), POLE(42), POLE2(6), PRIM1(6), RFC1(19), RFC2(3), RFC3(7), RFC4(2), RFC5(3), RPA1(6), RPA2(4), RPA3(1), RPA4(9), RPS27A(4), UBA52(2), UBB(2), UBC(9)	43588202	331	157	320	83	92	39	36	78	86	0	0.0378	1.000	1.000
281	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(7), AKR1D1(4), ARSD(6), ARSE(6), CARM1(10), CYP11B1(19), CYP11B2(12), CYP19A1(13), HEMK1(2), HSD11B1(5), HSD11B2(5), HSD17B1(5), HSD17B12(4), HSD17B2(3), HSD17B3(2), HSD17B7(5), HSD3B1(6), HSD3B2(5), LCMT1(2), LCMT2(11), METTL2B(1), METTL6(5), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), SULT2B1(2), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7), WBSCR22(5)	43003668	321	157	307	106	63	57	42	80	78	1	0.426	1.000	1.000
282	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(8), ARG1(3), ARG2(4), ASL(8), ASS1(11), CKB(7), CKM(2), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(35), DAO(15), EPRS(21), GAMT(2), GATM(5), GLUD1(5), GLUD2(17), GOT1(3), GOT2(2), LAP3(5), NOS1(45), NOS3(20), OAT(6), OTC(5), P4HA1(6), P4HA2(11), P4HA3(7), PRODH(1), PYCR1(3), PYCR2(5), PYCRL(3), RARS(9), RARS2(7)	31095388	293	157	278	91	80	37	39	77	60	0	0.284	1.000	1.000
283	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(5), CRK(2), CRKL(2), DOCK1(29), ELK1(6), FOS(2), GAB1(5), GRB2(4), HRAS(2), ITGA1(10), ITGB1(12), JUN(6), MAP2K1(9), MAP2K2(6), MAP4K1(4), MAPK1(4), MAPK3(3), MAPK8(7), MET(14), PAK1(7), PIK3R1(17), PTK2(12), PTK2B(20), PTPN11(10), PXN(9), RAF1(11), RAP1A(4), RAP1B(6), RASA1(28), SOS1(12), SRC(5), STAT3(9)	34544367	282	157	267	86	66	33	34	75	72	2	0.283	1.000	1.000
284	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	AKR1C3(3), ALOX12(11), ALOX15(12), ALOX5(15), CBR1(1), CBR3(4), CYP4F2(17), CYP4F3(14), EPX(18), GGT1(9), LPO(14), LTA4H(5), MPO(12), PLA2G2A(2), PLA2G2E(4), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PRDX1(3), PRDX2(3), PRDX6(5), PTGDS(3), PTGES2(6), PTGIS(10), PTGS1(15), PTGS2(7), TBXAS1(9), TPO(35)	23986464	269	157	261	73	98	29	22	72	45	3	0.0163	1.000	1.000
285	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(6), EGF(15), EGFR(24), ELK1(6), FOS(2), GRB2(4), HRAS(2), JAK1(22), JUN(6), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK3(3), MAPK8(7), PIK3R1(17), PLCG1(27), PRKCA(9), RAF1(11), RASA1(28), SHC1(7), SOS1(12), SRF(5), STAT1(14), STAT3(9), STAT5A(13)	30401918	294	156	276	66	71	40	29	62	87	5	0.00467	1.000	1.000
286	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(14), AKT1(7), AKT2(11), AKT3(10), DAG1(14), GNAQ(4), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(18), PIK3CB(17), PITX2(6), PLD1(26), PLD2(22), PLD3(9), VN1R1(7)	38792129	353	156	340	106	110	43	46	78	72	4	0.121	1.000	1.000
287	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	39	ALG1(9), ALG10B(11), ALG11(9), ALG12(13), ALG13(9), ALG14(3), ALG2(3), ALG3(4), ALG5(6), ALG6(6), ALG8(3), ALG9(3), B4GALT1(6), B4GALT2(9), B4GALT3(4), DDOST(1), DHDDS(2), DPAGT1(6), DPM1(2), FUT8(11), GANAB(21), MAN1A1(6), MAN1A2(7), MAN1B1(8), MAN1C1(11), MAN2A1(10), MGAT1(6), MGAT2(4), MGAT3(13), MGAT4A(6), MGAT4B(6), MGAT5(14), MGAT5B(15), RFT1(5), RPN1(7), RPN2(9), ST6GAL1(1), STT3B(10)	35249878	279	155	264	87	56	32	27	77	85	2	0.665	1.000	1.000
288	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), JAK1(22), JUN(6), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK3(3), MAPK8(7), PDGFA(4), PDGFRA(17), PIK3R1(17), PLCG1(27), PRKCA(9), RAF1(11), RASA1(28), SHC1(7), SOS1(12), SRF(5), STAT1(14), STAT3(9), STAT5A(13)	28219404	276	155	259	56	65	34	31	57	84	5	0.000913	1.000	1.000
289	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(36), ACAT1(9), ACAT2(6), ACYP1(2), ACYP2(3), ADH5(4), AKR1B1(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), DLAT(9), DLD(14), GLO1(3), GRHPR(4), HAGH(6), HAGHL(2), LDHA(7), LDHB(5), LDHC(1), LDHD(2), MDH1(5), MDH2(2), ME1(2), ME2(10), ME3(8), PC(19), PCK1(14), PDHA1(1), PDHA2(16), PDHB(4), PKLR(12)	31702004	297	155	278	96	77	48	34	63	75	0	0.432	1.000	1.000
290	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3E(3), CD4(11), CREBBP(59), CSK(10), GNAS(54), GNB1(2), GNGT1(4), HLA-DRA(7), HLA-DRB1(2), LCK(5), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PTPRC(30), ZAP70(16)	19792964	273	154	251	90	93	25	25	62	67	1	0.541	1.000	1.000
291	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3E(3), CD4(11), CREBBP(59), CSK(10), GNAS(54), GNB1(2), GNGT1(4), HLA-DRA(7), HLA-DRB1(2), LCK(5), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PTPRC(30), ZAP70(16)	19792964	273	154	251	90	93	25	25	62	67	1	0.541	1.000	1.000
292	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(12), ATM(71), ATR(33), CCNA1(13), CCND1(3), CCNE1(7), CDC25A(8), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN1B(1), CDKN2B(1), E2F1(6), GSK3B(9), HDAC1(10), RB1(22), SKP2(6), TFDP1(6), TGFB1(3), TGFB2(10), TGFB3(11)	24814408	252	154	240	66	42	32	32	59	84	3	0.207	1.000	1.000
293	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(7), AVP(5), CABIN1(28), CALM1(2), CALM2(3), CALM3(2), CAMK1(4), CAMK1G(10), HDAC5(15), IGF1(3), IGF1R(24), INSR(26), MAP2K6(1), MAPK14(3), MAPK7(9), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), MYOD1(8), NFATC1(20), NFATC2(32), PIK3R1(17), PPP3CA(14), PPP3CB(8), PPP3CC(9), SYT1(8), YWHAH(3)	28006550	288	154	277	102	92	32	38	54	70	2	0.322	1.000	1.000
294	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(11), ALDOC(11), DLAT(9), DLD(14), ENO1(4), ENO2(6), ENO3(4), FBP1(4), FBP2(8), GAPDH(5), GAPDHS(5), GCK(10), GOT1(3), GOT2(2), GPI(6), HK1(18), HK2(15), HK3(13), LDHA(7), LDHAL6B(7), LDHB(5), LDHC(1), MDH1(5), MDH2(2), PC(19), PCK1(14), PDHA1(1), PDHA2(16), PDHB(4), PDHX(6), PFKL(9), PFKM(6), PFKP(23), PGAM1(1), PGAM2(5), PGK1(5), PGK2(4), PKLR(12), TNFAIP1(6), TPI1(3)	36571696	310	152	300	121	97	62	27	66	58	0	0.626	1.000	1.000
295	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(5), AGTR1(1), ATF2(4), CALM1(2), CALM2(3), CALM3(2), EGFR(24), ELK1(6), GNAQ(4), GRB2(4), HRAS(2), JUN(6), MAP2K1(9), MAP2K2(6), MAP2K4(12), MAP3K1(24), MAPK1(4), MAPK3(3), MAPK8(7), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), PAK1(7), PRKCA(9), PTK2(12), PTK2B(20), RAC1(2), RAF1(11), SHC1(7), SOS1(12), SRC(5), SYT1(8)	29127629	248	151	235	75	66	27	27	57	70	1	0.201	1.000	1.000
296	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(34), DIAPH1(16), FYN(10), GSN(15), HRAS(2), ITGA1(10), ITGB1(12), MAP2K1(9), MAPK1(4), MAPK3(3), MYL2(9), MYLK(31), PFN1(1), PIK3R1(17), PTK2(12), PXN(9), RAF1(11), ROCK1(22), SHC1(7), SRC(5), TLN1(35)	30299930	274	150	260	66	75	36	36	60	60	7	0.00994	1.000	1.000
297	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(8), ARSB(4), FUCA1(2), FUCA2(5), GALNS(4), GBA(14), GLB1(9), GNS(10), GUSB(12), HEXA(2), HEXB(3), HGSNAT(8), HPSE(11), HPSE2(13), HYAL1(7), HYAL2(10), IDS(4), IDUA(5), LCT(32), MAN2B1(23), MAN2B2(25), MAN2C1(15), MANBA(11), NAGLU(11), NEU1(4), NEU2(9), NEU3(5), NEU4(7), SPAM1(11)	29738914	284	150	279	75	79	47	42	58	58	0	0.0116	1.000	1.000
298	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(21), ADRBK2(8), ARRB2(3), CALM1(2), CALM2(3), CALM3(2), CALML3(1), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CLCA1(10), CLCA2(12), CLCA4(20), CNGA3(13), CNGA4(20), CNGB1(21), GNAL(5), GUCA1A(3), GUCA1B(3), GUCA1C(5), PDC(3), PDE1C(17), PRKACA(9), PRKACB(6), PRKACG(9), PRKG1(15), PRKG2(20), PRKX(6)	26308908	264	150	249	73	71	25	34	69	65	0	0.0793	1.000	1.000
299	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(8), EIF1(2), EIF2B1(8), EIF2B2(5), EIF2B3(9), EIF2B4(12), EIF2B5(11), EIF2S1(3), EIF2S2(3), EIF2S3(3), ELAVL1(12), FLT1(26), FLT4(36), HIF1A(10), HRAS(2), KDR(22), NOS3(20), PIK3R1(17), PLCG1(27), PRKCA(9), PTK2(12), PXN(9), SHC1(7), VHL(2)	27477408	275	149	261	62	76	33	36	65	64	1	0.00261	1.000	1.000
300	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(5), ALAS1(5), ALAS2(16), BLVRA(7), BLVRB(1), COX10(2), COX15(5), CP(13), CPOX(5), EARS2(4), EPRS(21), FECH(8), FTH1(5), FTMT(10), GUSB(12), HCCS(6), HMBS(4), HMOX1(8), HMOX2(1), MMAB(3), PPOX(10), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7), UROD(3), UROS(6)	36042792	272	148	262	81	54	40	36	76	66	0	0.299	1.000	1.000
301	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(12), APC(68), AXIN1(17), BTRC(12), DLL1(17), DVL1(8), FZD1(15), GSK3B(9), NOTCH1(51), PSEN1(7)	16686553	216	148	203	62	52	17	20	40	79	8	0.241	1.000	1.000
302	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(7), AKT2(11), AKT3(10), CISH(4), GRB2(4), IARS(15), IL13RA1(6), IL2RG(12), IL4(4), IL4R(10), INPP5D(12), JAK1(22), JAK2(14), JAK3(18), NR0B2(4), PI3(2), PPP1R13B(19), RPS6KB1(6), SERPINA4(9), SHC1(7), SOS1(12), SOS2(19), SRC(5), STAT6(10), TYK2(15)	29942134	257	148	241	62	58	33	27	62	74	3	0.125	1.000	1.000
303	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(3), ALOX12(11), ALOX12B(16), ALOX15(12), ALOX15B(6), ALOX5(15), CBR1(1), CBR3(4), CYP2B6(9), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2E1(8), CYP2J2(5), CYP2U1(11), CYP4A11(4), CYP4A22(7), CYP4F2(17), CYP4F3(14), DHRS4(6), EPHX2(5), GGT1(9), GPX5(2), GPX7(4), LTA4H(5), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PTGDS(3), PTGES(1), PTGES2(6), PTGIS(10), PTGS1(15), PTGS2(7), TBXAS1(9)	33656963	296	147	291	79	107	32	28	75	52	2	0.00706	1.000	1.000
304	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(5), CDK5(3), CDK5R1(6), CFL1(2), CHN1(5), LIMK1(7), MAP3K1(24), MYL2(9), MYLK(31), NCF2(3), PAK1(7), PDGFRA(17), PIK3R1(17), PLD1(26), PPP1R12B(17), RAC1(2), RALBP1(12), RPS6KB1(6), TRIO(51), VAV1(21), WASF1(11)	28151865	282	147	268	78	72	34	31	68	74	3	0.147	1.000	1.000
305	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACAA2(13), ACADL(8), ACADM(7), ACADS(6), ACADSB(9), ACAT1(9), ACAT2(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH6A1(8), ALDH9A1(7), AOX1(18), BCAT1(6), BCKDHA(14), BCKDHB(6), ECHS1(3), EHHADH(5), HADHA(7), HADHB(6), HIBADH(3), IVD(5), MCCC1(5), MCCC2(10), MCEE(6), MUT(10), OXCT1(10), PCCA(15), PCCB(6), SDS(5)	30982747	294	147	270	72	55	51	35	60	92	1	0.0357	1.000	1.000
306	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(8), ALDH5A1(6), CAD(31), CPS1(35), EPRS(21), GAD1(11), GAD2(17), GCLC(4), GCLM(4), GFPT1(9), GLS(13), GLS2(8), GLUD1(5), GLUL(7), GMPS(10), GOT1(3), GOT2(2), GPT(8), GPT2(4), GSS(2), NADSYN1(13), PPAT(7), QARS(10)	28590427	242	146	235	71	57	34	34	64	53	0	0.204	1.000	1.000
307	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(3), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH7A1(2), ALDH9A1(7), AMDHD1(4), AOC2(14), AOC3(18), ASPA(4), CARM1(10), CNDP1(5), DDC(14), FTCD(9), HAL(5), HARS(10), HARS2(5), HDC(13), HEMK1(2), HNMT(3), LCMT1(2), LCMT2(11), MAOA(6), MAOB(6), METTL2B(1), METTL6(5), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), PRPS1(4), PRPS2(5), UROC1(15), WBSCR22(5)	34140304	307	146	283	76	71	35	36	72	91	2	0.0447	1.000	1.000
308	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(16), CALM1(2), CALM2(3), CALM3(2), CRKL(2), GNAQ(4), GRB2(4), HRAS(2), JUN(6), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K4(12), MAP3K1(24), MAPK1(4), MAPK14(3), MAPK3(3), MAPK8(7), PAK1(7), PLCG1(27), PRKCA(9), PTK2B(20), RAC1(2), RAF1(11), SHC1(7), SOS1(12), SRC(5), SYT1(8)	24564229	228	145	216	58	71	25	23	51	57	1	0.0267	1.000	1.000
309	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(4), CDC42(3), CREB1(4), DAXX(14), DDIT3(5), ELK1(6), GRB2(4), HMGN1(2), HRAS(2), HSPB1(2), HSPB2(2), MAP2K4(12), MAP2K6(1), MAP3K1(24), MAP3K5(18), MAP3K7(14), MAP3K9(7), MAPK14(3), MAPKAPK2(4), MAPKAPK5(6), MAX(4), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), MKNK1(6), MYC(6), PLA2G4A(8), RAC1(2), RIPK1(5), RPS6KA5(9), SHC1(7), STAT1(14), TGFB1(3), TGFB2(10), TGFB3(11), TGFBR1(10), TRADD(2), TRAF2(5)	31796384	266	144	255	72	66	38	32	54	73	3	0.0607	1.000	1.000
310	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(26), AKT1(7), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CREB1(4), GNAS(54), GRB2(4), HRAS(2), MAPK1(4), MAPK14(3), MAPK3(3), PIK3R1(17), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), RAC1(2), RPS6KA1(10), RPS6KA5(9), SOS1(12)	23250433	237	143	224	68	82	28	21	49	54	3	0.198	1.000	1.000
311	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(6), B4GALT5(5), C1GALT1(4), C1GALT1C1(6), GALNT1(4), GALNT10(10), GALNT11(7), GALNT12(6), GALNT13(14), GALNT14(15), GALNT2(9), GALNT3(6), GALNT4(6), GALNT5(14), GALNT6(7), GALNT7(4), GALNT8(12), GALNT9(6), GALNTL5(5), GCNT1(4), GCNT3(5), GCNT4(8), OGT(10), ST3GAL1(7), ST3GAL2(11), ST6GALNAC1(7), WBSCR17(37)	27814492	235	143	227	81	75	27	26	61	45	1	0.751	1.000	1.000
312	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(7), AKT2(11), AKT3(10), BAD(4), BCL2(4), GRB2(4), GSK3A(6), GSK3B(9), IL4R(10), IRS1(33), IRS2(13), JAK1(22), JAK3(18), MAP4K1(4), MAPK1(4), MAPK3(3), PDK1(3), PIK3CD(20), PIK3R1(17), PPP1R13B(19), RAF1(11), SHC1(7), SOCS1(1), SOS1(12), SOS2(19), STAT6(10)	29578060	281	143	261	71	76	35	27	54	85	4	0.0885	1.000	1.000
313	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(6), ARSD(6), ARSE(6), ASAH1(4), B4GALT6(9), CERK(11), DEGS1(2), DEGS2(3), ENPP7(5), GAL3ST1(14), GALC(5), GBA(14), GLA(3), GLB1(9), LCT(32), NEU1(4), NEU2(9), NEU3(5), NEU4(7), PPAP2A(5), PPAP2B(5), PPAP2C(6), SGMS1(5), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(8), SMPD2(3), SMPD3(11), SMPD4(13), SPHK1(10), SPHK2(11), SPTLC1(6), SPTLC2(8), UGCG(4), UGT8(7)	30746838	265	142	257	94	81	36	35	56	57	0	0.449	1.000	1.000
314	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(4), BCR(18), BLNK(8), ELK1(6), FOS(2), GRB2(4), HRAS(2), JUN(6), LYN(9), MAP2K1(9), MAP3K1(24), MAPK1(4), MAPK3(3), MAPK8IP3(16), PAPPA(35), RAC1(2), RPS6KA1(10), RPS6KA3(6), SHC1(7), SOS1(12), SYK(11), VAV1(21), VAV2(14), VAV3(16)	27692989	249	142	238	84	68	33	29	63	56	0	0.379	1.000	1.000
315	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), DAG1(14), ITPKA(2), ITPKB(20), ITPR1(40), ITPR2(41), ITPR3(46), NFAT5(17), PDE6A(11), PDE6B(15), PDE6C(8), PDE6D(1), PDE6G(1), PDE6H(3), SLC6A13(13), TF(19)	30796430	278	142	270	101	92	35	36	64	48	3	0.405	1.000	1.000
316	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(3), CALM3(2), CHUK(10), EGR2(9), EGR3(9), GNAQ(4), MAP3K1(24), MYC(6), NFATC1(20), NFATC2(32), NFKB1(10), NFKBIA(1), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RELA(7), SYT1(8), VIP(9), VIPR2(5)	23855646	263	142	246	76	84	35	20	52	72	0	0.0818	1.000	1.000
317	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ACADL(8), ACADM(7), ACADSB(9), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), AOC2(14), AOC3(18), CNDP1(5), DPYD(25), DPYS(12), ECHS1(3), EHHADH(5), GAD1(11), GAD2(17), HADHA(7), MLYCD(8), SDS(5), SMS(6), UPB1(6)	24939311	255	141	238	58	58	33	30	63	71	0	0.00433	1.000	1.000
318	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(8), POLA2(6), POLB(8), POLD1(18), POLD2(8), POLD3(7), POLE(42), POLE2(6), POLE3(4), POLE4(1), POLG(10), POLG2(5), POLH(9), POLI(4), POLK(10), POLL(4), POLM(14), POLQ(46), PRIM1(6), PRIM2(10), REV1(13), REV3L(61), RFC5(3)	35097861	303	141	293	91	67	49	33	63	87	4	0.563	1.000	1.000
319	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(22), ANAPC10(2), ANAPC11(1), ANAPC2(9), ANAPC4(4), ANAPC5(8), ANAPC7(7), BTRC(12), CDC16(7), CDC20(10), CDC23(7), CDC26(3), CDC27(12), CUL1(28), CUL2(10), CUL3(11), FBXW11(9), FZR1(12), ITCH(7), RBX1(1), SKP2(6), SMURF1(9), SMURF2(7), TCEB1(1), UBA1(8), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2D3(3), UBE2E1(4), UBE2E2(1), UBE2E3(3), VHL(2), WWP1(19), WWP2(18)	33256982	267	141	254	58	65	38	30	58	74	2	0.00428	1.000	1.000
320	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(68), ASAH1(4), CAMP(3), CASP3(2), CERK(11), CREB1(4), CREB5(9), CXCL2(2), DAG1(14), EPHB2(19), FOS(2), GNAQ(4), ITPKA(2), ITPKB(20), JUN(6), MAP2K4(12), MAPK1(4), MAPK10(7), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7)	23699038	236	141	226	71	57	27	27	47	73	5	0.262	1.000	1.000
321	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(11), BAK1(5), BAX(3), BCL2(4), BCL2L1(2), BID(3), BIRC2(8), BIRC3(12), CASP2(5), CASP3(2), CASP6(2), CASP7(5), CASP9(4), FADD(4), FAS(3), FASLG(6), GZMB(2), JUN(6), MAP2K4(12), MAP3K1(24), MAPK10(7), MCL1(3), MDM2(10), MYC(6), NFKB1(10), NFKBIA(1), PARP1(15), PRF1(17), RELA(7), RIPK1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TNFSF10(10), TRADD(2), TRAF1(6), TRAF2(5)	30379711	240	140	226	71	59	34	23	51	70	3	0.184	1.000	1.000
322	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(14), CFL1(2), GNAQ(4), GNAS(54), GNB1(2), GNGT1(4), HRAS(2), LIMK1(7), MAP2K1(9), MAPK1(4), MAPK3(3), MYL2(9), NOX1(8), PIK3C2G(18), PLCB1(24), PPP1R12B(17), PRKCA(9), PTK2(12), RAF1(11), ROCK2(20)	21804196	234	140	218	41	80	28	21	54	51	0	0.000262	1.000	1.000
323	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), AOC2(14), AOC3(18), DDC(14), EPX(18), ESCO1(13), ESCO2(11), GOT1(3), GOT2(2), HPD(4), LPO(14), MAOA(6), MAOB(6), MIF(2), MPO(12), NAT6(4), PNPLA3(4), PRDX6(5), SH3GLB1(5), TAT(7), TPO(35)	29319735	236	140	219	53	61	21	17	62	73	2	0.0499	1.000	1.000
324	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(3), GHR(11), GRB2(4), HRAS(2), INSR(26), IRS1(33), JAK2(14), MAP2K1(9), MAPK1(4), MAPK3(3), PIK3R1(17), PLCG1(27), PRKCA(9), PTPN6(6), RAF1(11), RPS6KA1(10), SHC1(7), SLC2A4(5), SOCS1(1), SOS1(12), SRF(5), STAT5A(13), STAT5B(15)	26602181	247	139	236	68	69	39	29	44	62	4	0.0626	1.000	1.000
325	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), FPGT(12), FUK(12), GMDS(2), GMPPA(8), GMPPB(6), HK1(18), HK2(15), HK3(13), HSD3B7(9), KHK(2), LHPP(4), MPI(3), MTMR1(8), MTMR2(10), MTMR6(14), PFKFB1(8), PFKFB2(6), PFKFB3(10), PFKFB4(6), PFKL(9), PFKM(6), PFKP(23), PGM2(1), PHPT1(2), PMM1(4), PMM2(3), RDH11(1), RDH12(3), RDH13(8), SORD(3), TPI1(3), TSTA3(11)	32223833	290	139	282	95	95	48	32	52	63	0	0.110	1.000	1.000
326	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(6), B4GALT2(9), FBP2(8), GAA(11), GALE(2), GALK1(4), GALK2(3), GALT(3), GANAB(21), GCK(10), GLA(3), GLB1(9), HK1(18), HK2(15), HK3(13), LALBA(1), LCT(32), MGAM(28), PFKM(6), PFKP(23), PGM1(4), PGM3(13)	28031353	248	138	230	93	81	33	23	61	50	0	0.757	1.000	1.000
327	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	22	AKT1(7), APC(68), AXIN1(17), CCND1(3), CD14(2), DVL1(8), FZD1(15), GJA1(14), GNAI1(4), GSK3B(9), IRAK1(9), LBP(3), LEF1(5), LY96(5), MYD88(4), NFKB1(10), PDPK1(1), PIK3R1(17), PPP2CA(5), RELA(7), TIRAP(1), TOLLIP(7)	21135595	221	138	210	61	44	24	29	39	78	7	0.132	1.000	1.000
328	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(4), CREBBP(59), EP300(39), FYN(10), IL2RG(12), IL7(2), IL7R(18), JAK1(22), JAK3(18), LCK(5), NMI(2), PIK3R1(17), PTK2B(20), STAT5A(13), STAT5B(15)	22136795	256	138	237	52	56	28	28	60	81	3	0.00702	1.000	1.000
329	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(5), CAPN1(8), CAPN2(11), CAPNS1(6), CAPNS2(3), CXCR3(3), EGF(15), EGFR(24), HRAS(2), ITGA1(10), ITGB1(12), MAPK1(4), MAPK3(3), MYL2(9), MYLK(31), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PTK2(12), PXN(9), TLN1(35)	28243838	246	138	236	91	82	39	23	51	50	1	0.499	1.000	1.000
330	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(11), AZIN1(4), BTG1(1), CLDN5(4), CLOCK(8), CRY1(4), CRY2(9), DAZAP2(7), DNAJA1(13), EIF4G2(1), ETV6(9), G0S2(3), GFRA1(13), GSTM3(3), GSTP1(2), HERPUD1(3), HSPA8(5), IDI1(3), KLF9(3), MYF6(5), NCKAP1(17), NCOA4(9), NR1D2(11), PER1(11), PER2(20), PPP1R3C(4), PPP2CB(4), PSMA4(4), PURA(3), SF3A3(3), TOB1(3), TUBB3(12), UCP3(6), UGP2(9), VAPA(4), ZFR(18)	30971068	249	137	241	82	61	30	32	54	71	1	0.667	1.000	1.000
331	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(17), ATP4B(5), ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(13), ATP6V0B(6), ATP6V0C(2), ATP6V0D1(9), ATP6V1A(7), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(16), ATP6V1D(5), ATP6V1E1(4), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(18), ATP7A(16), ATP7B(19), COX10(2), COX4I1(4), COX5A(1), COX5B(1), COX6B1(2), COX6C(1), COX7A1(2), COX7B(3), COX7C(1), COX8A(1), NDUFA1(2), NDUFA10(4), NDUFA4(1), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(8), NDUFS2(8), NDUFV1(6), NDUFV2(2), PPA2(4), SDHA(15), SDHB(4), SHMT1(4), UQCRB(2), UQCRC1(3), UQCRFS1(4)	31976382	262	137	257	79	76	38	39	54	54	1	0.113	1.000	1.000
332	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(26), ARHGEF1(15), F2(15), F2R(10), F2RL3(6), GNA12(2), GNA13(10), GNAI1(4), GNAQ(4), GNB1(2), GNGT1(4), MAP3K7(14), PIK3R1(17), PLCB1(24), PPP1R12B(17), PRKCA(9), PTK2B(20), ROCK1(22)	20380360	221	137	214	59	59	24	27	50	57	4	0.104	1.000	1.000
333	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(6), B4GALT1(6), B4GALT2(9), G6PC2(1), GAA(11), GALE(2), GALK1(4), GALK2(3), GALT(3), GANC(10), GCK(10), GLA(3), GLB1(9), HK1(18), HK2(15), HK3(13), HSD3B7(9), LALBA(1), LCT(32), MGAM(28), PFKL(9), PFKM(6), PFKP(23), PGM1(4), PGM3(13), RDH11(1), RDH12(3), RDH13(8), UGP2(9)	33295060	275	136	261	108	96	37	28	60	54	0	0.849	1.000	1.000
334	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(5), DLG4(8), EPHB2(19), F2(15), F2RL1(2), F2RL2(5), F2RL3(6), JUN(6), MAP2K5(3), MAPK1(4), MAPK7(9), MAPK8(7), MYEF2(10), PLD1(26), PLD2(22), PLD3(9), PTK2(12), RAF1(11), RASAL1(11), SRC(5), TEC(5), VAV1(21)	23632299	221	136	216	57	65	28	23	50	55	0	0.0493	1.000	1.000
335	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(9), ACP2(6), ACP5(4), ACPP(8), ACPT(6), ALPI(7), ALPL(10), ALPP(16), ALPPL2(6), CYP19A1(13), CYP1A1(10), CYP1A2(6), CYP2A13(15), CYP2A6(8), CYP2A7(9), CYP2B6(9), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2D6(15), CYP2E1(8), CYP2F1(13), CYP2J2(5), CYP3A4(3), CYP3A5(3), CYP3A7(5), CYP4B1(12), CYP51A1(13), PON1(4)	25398139	246	134	235	78	88	27	22	56	53	0	0.173	1.000	1.000
336	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(26), EXT2(8), EXTL1(8), EXTL2(2), EXTL3(15), GLCE(9), HS2ST1(4), HS3ST1(10), HS3ST2(12), HS3ST3A1(5), HS3ST3B1(5), HS3ST5(10), HS6ST1(9), HS6ST2(11), HS6ST3(9), NDST1(18), NDST2(18), NDST3(23), NDST4(23)	17839649	225	134	213	76	68	34	27	66	29	1	0.437	1.000	1.000
337	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(4), AKT1(7), AKT2(11), AKT3(10), BAD(4), BTK(5), DAPP1(2), GRB2(4), GSK3A(6), GSK3B(9), IARS(15), IGFBP1(11), INPP5D(12), PDK1(3), PPP1R13B(19), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SOS1(12), SOS2(19), TEC(5), YWHAB(3), YWHAE(5), YWHAG(4), YWHAH(3), YWHAQ(5), YWHAZ(4)	27914002	225	134	218	71	56	31	26	54	58	0	0.499	1.000	1.000
338	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(21), BAIAP2(7), CASP1(8), CASP3(2), CASP7(5), GAPDH(5), INSR(26), ITCH(7), MAGI1(30), MAGI2(36), RERE(37), WWP1(19), WWP2(18)	19423566	221	133	214	54	51	25	26	57	60	2	0.0559	1.000	1.000
339	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(7), BAD(4), BCL2(4), BCL2L1(2), CBL(11), CFLAR(3), CRKL(2), E2F1(6), FOS(2), GRB2(4), HRAS(2), IL2RA(3), IL2RB(3), IL2RG(12), IRS1(33), JAK1(22), JAK3(18), MAPK1(4), MAPK3(3), MYC(6), NMI(2), PIK3R1(17), PTPN6(6), RAF1(11), RPS6KB1(6), SHC1(7), SOCS1(1), SOCS3(4), SOS1(12), STAT5A(13), STAT5B(15), SYK(11)	29376584	256	132	240	74	55	36	31	57	73	4	0.330	1.000	1.000
340	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(28), CALM1(2), CALM2(3), CALM3(2), CAPN2(11), CAPNS1(6), CAPNS2(3), EP300(39), HDAC1(10), HDAC2(6), MEF2D(11), NFATC1(20), NFATC2(32), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKCA(9), SYT1(8)	20858772	221	132	208	55	70	26	22	49	54	0	0.00534	1.000	1.000
341	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(36), ACADL(8), ACADM(7), ACADSB(9), ACAT1(9), ACAT2(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH6A1(8), ALDH9A1(7), ECHS1(3), EHHADH(5), HADHA(7), LDHA(7), LDHB(5), LDHC(1), MCEE(6), MLYCD(8), MUT(10), PCCA(15), PCCB(6), SDS(5), SUCLA2(3), SUCLG1(4), SUCLG2(9)	28474853	266	132	243	61	60	43	32	57	74	0	0.0223	1.000	1.000
342	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(9), GTF2A1(3), GTF2B(3), GTF2E1(7), GTF2F1(11), HDAC3(10), NCOA1(27), NCOA2(33), NCOA3(18), NCOR2(52), POLR2A(27), RARA(4), RXRA(13), TBP(8)	21527996	225	132	222	82	63	41	25	50	43	3	0.590	1.000	1.000
343	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(5), ACTN1(8), ACTN2(34), CAPN1(8), CAPNS1(6), CAPNS2(3), ITGA1(10), ITGB1(12), ITGB3(8), PTK2(12), PXN(9), RAC1(2), SPTAN1(30), SRC(5), TLN1(35)	24615049	187	132	179	70	79	21	13	47	27	0	0.623	1.000	1.000
344	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(12), ATM(71), BRCA1(22), CDKN1A(7), CHEK1(7), CHEK2(13), JUN(6), MAPK8(7), MDM2(10), MRE11A(9), NFKB1(10), NFKBIA(1), RAD50(15), RAD51(4), RBBP8(8), RELA(7), TP73(9)	24802662	218	131	201	45	34	28	22	58	72	4	0.0546	1.000	1.000
345	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(10), CALCR(6), CALCRL(11), CD97(11), CRHR1(14), CRHR2(4), ELTD1(26), EMR1(18), EMR2(12), GHRHR(6), GIPR(7), GLP1R(2), GLP2R(12), GPR64(15), LPHN1(23), LPHN2(32), SCTR(5), VIPR1(3), VIPR2(5)	20961496	222	131	213	56	50	34	23	73	42	0	0.00938	1.000	1.000
346	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(4), BRAF(22), CREB1(4), CREB5(9), DUSP4(3), DUSP6(5), DUSP9(10), EEF2K(15), EIF4E(2), GRB2(4), MAP2K1(9), MAP2K2(6), MAP3K8(2), MAPK1(4), MAPK3(3), MKNK1(6), MKNK2(10), MOS(11), NFKB1(10), RAP1A(4), RPS6KA1(10), RPS6KA2(13), RPS6KA3(6), SHC1(7), SOS1(12), SOS2(19), TRAF3(8)	25452530	218	131	202	81	59	32	14	57	56	0	0.847	1.000	1.000
347	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ACADM(7), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), AOC2(14), AOC3(18), CNDP1(5), DPYD(25), DPYS(12), ECHS1(3), EHHADH(5), GAD1(11), GAD2(17), HADHA(7), HIBCH(6), MLYCD(8), SMS(6), SRM(4), UPB1(6)	23163802	226	130	209	49	52	28	26	56	64	0	0.00353	1.000	1.000
348	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(5), ADCY1(26), CAP1(2), CCNB1(4), CDC25C(11), GNAI1(4), GNAS(54), GNB1(2), GNGT1(4), HRAS(2), MAPK1(4), MAPK3(3), MYT1(26), PIN1(2), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RPS6KA1(10), SRC(5)	17707353	208	130	194	72	77	26	13	48	42	2	0.542	1.000	1.000
349	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(20), DYRK1B(19), GLI2(23), GLI3(69), GSK3B(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), SHH(6), SMO(19), SUFU(8)	14244054	217	130	207	79	70	29	18	51	47	2	0.362	1.000	1.000
350	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(7), CDC42(3), CREB1(4), CREB5(9), DUSP1(3), DUSP10(11), EEF2K(15), EIF4E(2), ELK1(6), HSPB1(2), IL1R1(5), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K10(17), MAP3K4(32), MAP3K5(18), MAP3K7(14), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPKAPK2(4), MAPKAPK5(6), MKNK1(6), MKNK2(10), MYEF2(10), NFKB1(10), NR2C2(10), SRF(5), TRAF6(7)	28881519	254	130	243	70	60	49	29	55	60	1	0.0243	1.000	1.000
351	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(6), AGMAT(5), ALDH18A1(12), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), AMD1(8), AOC2(14), AOC3(18), ARG1(3), ARG2(4), ASL(8), ASS1(11), CPS1(35), GATM(5), MAOA(6), MAOB(6), NAGS(2), ODC1(4), OTC(5), SAT1(3), SMS(6), SRM(4)	25312769	233	129	219	46	55	25	30	59	64	0	0.00200	1.000	1.000
352	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(10), ALDH3A1(16), ALDH3B1(6), ALDH3B2(7), AOC2(14), AOC3(18), DDC(14), EPX(18), GOT1(3), GOT2(2), HPD(4), LPO(14), MAOA(6), MAOB(6), MPO(12), PRDX1(3), PRDX2(3), PRDX6(5), TAT(7), TPO(35)	18976283	203	129	187	52	55	20	17	55	54	2	0.0962	1.000	1.000
353	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(2), CHUK(10), ELK1(6), FOS(2), IKBKB(12), IRAK1(9), JUN(6), LY96(5), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K1(24), MAP3K7(14), MAPK14(3), MAPK8(7), MYD88(4), NFKB1(10), NFKBIA(1), PPARA(8), RELA(7), TIRAP(1), TLR10(12), TLR2(9), TLR3(7), TLR6(6), TLR7(7), TLR9(15), TOLLIP(7), TRAF6(7)	29764819	225	129	217	64	51	33	27	44	69	1	0.0794	1.000	1.000
354	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(6), FOS(2), GRB2(4), HRAS(2), JAK2(14), JUN(6), MAP2K1(9), MAPK3(3), MPL(7), PIK3R1(17), PLCG1(27), PRKCA(9), RAF1(11), RASA1(28), SHC1(7), SOS1(12), STAT1(14), STAT3(9), STAT5A(13), STAT5B(15), THPO(8)	23944885	223	129	213	44	58	28	22	52	60	3	0.00236	1.000	1.000
355	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(7), APAF1(11), ATM(71), BAD(4), BAX(3), BCL2(4), BCL2L1(2), BID(3), CASP3(2), CASP6(2), CASP7(5), CASP9(4), EIF2S1(3), PRKCA(9), PTK2(12), PXN(9), STAT1(14), TLN1(35)	22864904	200	128	192	38	58	32	20	41	46	3	0.000575	1.000	1.000
356	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(3), CALM3(2), DLG4(8), GRIN1(11), GRIN2A(23), GRIN2B(31), GRIN2C(13), GRIN2D(12), NOS1(45), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), PRKCA(9), SYT1(8)	21939046	242	128	231	86	77	34	25	53	53	0	0.362	1.000	1.000
357	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(15), ABAT(4), ACADS(6), ACAT1(9), ACAT2(6), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH5A1(6), ALDH9A1(7), ECHS1(3), EHHADH(5), GAD1(11), GAD2(17), HADHA(7), L2HGDH(5), OXCT1(10), PDHA1(1), PDHA2(16), PDHB(4), SDHB(4), SDS(5)	22138651	219	126	203	68	51	31	21	54	62	0	0.303	1.000	1.000
358	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(16), CRK(2), CXCR4(1), GNAI1(4), GNAQ(4), GNB1(2), GNGT1(4), HRAS(2), MAP2K1(9), MAPK1(4), MAPK3(3), NFKB1(10), PIK3C2G(18), PIK3R1(17), PLCG1(27), PRKCA(9), PTK2(12), PTK2B(20), PXN(9), RAF1(11), RELA(7)	22065536	191	125	183	43	57	23	20	36	54	1	0.00711	1.000	1.000
359	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(11), BCL2(4), BID(3), BIRC2(8), BIRC3(12), CASP10(8), CASP3(2), CASP6(2), CASP7(5), CASP9(4), CFLAR(3), CHUK(10), DFFA(5), DFFB(5), FADD(4), GAS2(4), LMNA(13), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), SPTAN1(30), TNFRSF10A(3), TNFRSF10B(3), TNFRSF25(9), TNFSF10(10), TNFSF12(2), TRADD(2), TRAF2(5)	27772733	190	125	183	58	47	31	14	51	46	1	0.438	1.000	1.000
360	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(13), ACO1(9), ACO2(12), CLYBL(4), CS(1), DLD(14), DLST(6), FH(4), IDH1(5), IDH2(8), IDH3A(3), IDH3B(3), IDH3G(7), MDH1(5), MDH2(2), OGDH(13), OGDHL(25), PC(19), PCK1(14), PCK2(12), SDHA(15), SDHB(4), SDHC(2), SDHD(3), SUCLA2(3), SUCLG1(4), SUCLG2(9)	25715662	219	125	209	58	67	35	24	39	54	0	0.0319	1.000	1.000
361	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(12), CS(1), DLAT(9), DLD(14), DLST(6), FH(4), IDH2(8), IDH3A(3), IDH3B(3), IDH3G(7), MDH1(5), MDH2(2), OGDH(13), PC(19), PDHA1(1), PDHA2(16), PDHB(4), PDHX(6), PDK1(3), PDK2(2), PDK3(8), PDK4(6), PDP2(5), SDHA(15), SDHB(4), SDHC(2), SDHD(3), SUCLA2(3), SUCLG1(4), SUCLG2(9)	24468445	197	125	187	62	49	33	24	40	51	0	0.365	1.000	1.000
362	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(10), CREBBP(59), DUSP1(3), EP300(39), IKBKB(12), IL1B(7), MAP2K3(11), MAP2K6(1), MAP3K7(14), MAPK11(2), MAPK14(3), MYD88(4), NFKB1(10), NFKBIA(1), NR3C1(10), RELA(7), TGFBR1(10), TLR2(9), TNF(3)	24402446	215	125	207	56	48	25	28	51	63	0	0.0790	1.000	1.000
363	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(3), GORASP1(5), MAP2K4(12), MAPK1(4), MAPK10(7), MAPK11(2), MAPK12(1), MAPK13(4), MAPK14(3), MAPK3(3), MAPK8(7), MAPK8IP1(5), MAPK8IP2(8), MAPK8IP3(16), MAPK9(7), MAPKAPK5(6), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PIK3CD(20), PIK3R1(17), SYT1(8), TRAF2(5), TRAF3(8), TRAF5(7), TRAF6(7)	26635474	201	125	196	56	60	24	16	41	56	4	0.107	1.000	1.000
364	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(7), BCL2(4), BCR(18), CRKL(2), FOS(2), GRB2(4), HRAS(2), JAK2(14), JUN(6), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK3(3), MAPK8(7), MYC(6), PIK3R1(17), RAF1(11), SOS1(12), STAT1(14), STAT5A(13), STAT5B(15)	22306319	202	124	191	54	46	27	20	43	63	3	0.0824	1.000	1.000
365	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAA2(13), ACAD8(6), ACAD9(9), ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), AKR1B10(6), AKR1C4(7), AKR1D1(4), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), BAAT(6), CEL(20), CYP27A1(8), CYP7A1(7), HADHB(6), HSD3B7(9), LIPA(3), RDH11(1), RDH12(3), RDH13(8), SLC27A5(6), SOAT1(12), SOAT2(4), SRD5A1(2)	27335024	249	124	231	73	56	37	43	52	61	0	0.163	1.000	1.000
366	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(43), C5(15), C6(19), C7(11), ICAM1(5), IL1A(2), IL6(1), ITGA4(21), ITGAL(28), ITGB1(12), ITGB2(12), SELP(14), SELPLG(10), TNF(3), VCAM1(13)	21350161	209	124	198	61	54	27	22	62	44	0	0.0709	1.000	1.000
367	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(11), EGF(15), EGFR(24), GRB2(4), HRAS(2), MAP2K1(9), MAPK1(4), MAPK3(3), PTPRB(28), RAF1(11), RASA1(28), SHC1(7), SOS1(12), SPRY1(2), SPRY3(8), SPRY4(8), SRC(5)	21531432	181	123	173	55	43	29	17	53	38	1	0.378	1.000	1.000
368	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(35), COL4A2(24), COL4A3(19), COL4A4(25), COL4A5(26), COL4A6(15), P4HB(5), SLC23A1(8), SLC23A2(14), SLC2A1(9), SLC2A3(11)	21774056	191	123	185	66	51	33	21	47	37	2	0.228	1.000	1.000
369	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(14), AGT(5), AGTR1(1), AGTR2(6), CMA1(3), COL4A1(35), COL4A2(24), COL4A3(19), COL4A4(25), COL4A5(26), COL4A6(15), REN(9)	21858405	182	122	179	59	42	36	18	47	37	2	0.256	1.000	1.000
370	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(10), CARS(11), DARS(2), EPRS(21), FARS2(9), GARS(6), HARS(10), IARS(15), KARS(9), LARS(13), LARS2(12), MARS(10), MARS2(6), NARS(5), QARS(10), RARS(9), SARS(11), TARS(17), WARS(5), WARS2(14), YARS(9)	27469235	214	122	207	56	55	26	33	57	43	0	0.0932	1.000	1.000
371	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(10), IFNA1(1), IFNB1(4), IKBKB(12), IL1A(2), IL1B(7), IL1R1(5), IL1RAP(8), IL1RN(2), IL6(1), IRAK1(9), IRAK2(11), IRAK3(10), JUN(6), MAP2K3(11), MAP2K6(1), MAP3K1(24), MAP3K7(14), MAPK14(3), MAPK8(7), MYD88(4), NFKB1(10), NFKBIA(1), RELA(7), TGFB1(3), TGFB2(10), TGFB3(11), TNF(3), TOLLIP(7), TRAF6(7)	25597541	211	122	200	60	45	31	20	48	66	1	0.229	1.000	1.000
372	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), ERCC3(9), GTF2A2(1), GTF2B(3), GTF2E1(7), GTF2E2(4), GTF2F2(3), GTF2H1(6), GTF2H4(9), ILK(11), MNAT1(4), POLR1A(23), POLR1B(11), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLR3B(16), POLR3D(7), POLR3E(6), POLR3H(2), POLR3K(2), TAF13(1), TAF5(4), TAF6(15), TAF7(8), TBP(8)	30042255	222	122	217	81	62	23	32	44	61	0	0.809	1.000	1.000
373	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(34), ARHGEF1(15), GNA12(2), GNA13(10), GNAQ(4), GNB1(2), GNGT1(4), MYL2(9), MYLK(31), PLCB1(24), PPP1R12B(17), PRKCA(9), ROCK1(22)	17867773	183	121	174	45	43	23	26	42	43	6	0.0747	1.000	1.000
374	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(6), CSNK1D(5), DRD1(7), DRD2(14), GRM1(52), PLCB1(24), PPP1CA(3), PPP1R1B(3), PPP2CA(5), PPP3CA(14), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12)	13681358	180	120	172	50	50	28	19	43	40	0	0.0626	1.000	1.000
375	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(7), CHIT1(5), CMAS(7), CTBS(4), CYB5R1(4), CYB5R3(4), GFPT1(9), GFPT2(9), GNE(12), GNPDA1(4), GNPDA2(7), GNPNAT1(6), HEXA(2), HEXB(3), HK1(18), HK2(15), HK3(13), LHPP(4), MTMR1(8), MTMR2(10), MTMR6(14), NAGK(2), NANS(9), NPL(5), PGM3(13), PHPT1(2), RENBP(5), UAP1(6)	24748721	212	120	203	58	53	36	26	53	44	0	0.0356	1.000	1.000
376	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(8), ACTN2(34), BCAR1(16), CSK(10), CTNNA1(24), CTNNA2(32), PTK2(12), PXN(9), SRC(5), VCL(19)	15242272	169	119	161	56	65	11	20	43	27	3	0.355	1.000	1.000
377	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(18), CHAT(14), COMT(5), DBH(8), DDC(14), GAD1(11), GAD2(17), HDC(13), MAOA(6), PAH(10), PNMT(11), SLC18A3(17), TH(10), TPH1(6)	12429423	162	118	156	60	56	19	12	38	36	1	0.491	1.000	1.000
378	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(26), GNAS(54), GNB1(2), GNGT1(4), PPP2CA(5), PRKAA1(9), PRKAA2(11), PRKAB2(6), PRKACB(6), PRKACG(9), PRKAG1(6), PRKAG2(8), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12)	12757082	175	118	164	48	65	17	14	36	41	2	0.261	1.000	1.000
379	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(7), EIF4A1(4), EIF4A2(8), EIF4E(2), EIF4EBP1(5), EIF4G1(31), EIF4G2(1), EIF4G3(26), GHR(11), IRS1(33), MAPK1(4), MAPK14(3), MAPK3(3), MKNK1(6), PABPC1(12), PDK2(2), PDPK1(1), PIK3R1(17), PRKCA(9), RPS6KB1(6)	21663703	191	118	180	39	36	25	28	33	66	3	0.0240	1.000	1.000
380	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(9), AKT1(7), ANXA1(6), CALM1(2), CALM2(3), CALM3(2), GNAS(54), GNB1(2), GNGT1(4), NFKB1(10), NOS3(20), NPPA(2), NR3C1(10), PIK3R1(17), RELA(7), SYT1(8)	13607959	163	118	148	33	58	16	13	36	39	1	0.0156	1.000	1.000
381	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), INSR(26), IRS1(33), JUN(6), MAP2K1(9), MAPK3(3), MAPK8(7), PIK3R1(17), PTPN11(10), RAF1(11), RASA1(28), SHC1(7), SLC2A4(5), SOS1(12), SRF(5)	20021487	199	118	186	41	45	26	22	41	61	4	0.00391	1.000	1.000
382	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(10), ABAT(4), ADSL(8), ADSS(6), AGXT(5), AGXT2(13), ASL(8), ASNS(10), ASPA(4), CAD(31), CRAT(14), DARS(2), DDO(7), GAD1(11), GAD2(17), GOT1(3), GOT2(2), GPT(8), GPT2(4), NARS(5), PC(19)	22500131	191	117	181	63	65	24	23	40	39	0	0.313	1.000	1.000
383	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(2), CALM2(3), CALM3(2), CDKN1A(7), GNAQ(4), MARCKS(2), NFATC1(20), NFATC2(32), NFATC3(7), NFATC4(20), PLCG1(27), PPP3CA(14), PPP3CB(8), PPP3CC(9), PRKCA(9), SP1(6), SP3(7), SYT1(8)	17829857	187	116	178	43	67	33	15	33	39	0	0.000831	1.000	1.000
384	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(26), AKT1(7), ASAH1(4), GNAI1(4), GNB1(2), GNGT1(4), ITGAV(23), ITGB3(8), MAPK1(4), MAPK3(3), PDGFA(4), PDGFRA(17), PIK3R1(17), PLCB1(24), PRKCA(9), PTK2(12), RAC1(2), SMPD1(8), SMPD2(3), SPHK1(10), SRC(5)	21682850	196	116	187	62	52	25	29	32	56	2	0.365	1.000	1.000
385	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(59), DAXX(14), HRAS(2), PAX3(14), PML(20), RARA(4), RB1(22), SIRT1(13), SP100(26), TNF(3), TNFRSF1A(6), TNFRSF1B(4)	15602760	187	116	180	43	51	21	28	33	54	0	0.00948	1.000	1.000
386	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(55), MAP2(51), PPP1CA(3), PPP2CA(5), PRKACB(6), PRKACG(9), PRKAG1(6), PRKAR2A(3), PRKAR2B(12), PRKCE(16)	15448690	166	115	159	49	26	19	25	58	36	2	0.549	1.000	1.000
387	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(26), AKT1(7), BAD(4), BAX(3), BCL2(4), BCL2L1(2), CSF2RB(18), IGF1(3), IGF1R(24), IL3(3), IL3RA(6), KIT(20), KITLG(6), PIK3R1(17), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), YWHAH(3)	17008108	190	115	186	78	48	28	29	38	45	2	0.812	1.000	1.000
388	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(15), F2R(10), F2RL3(6), GNAI1(4), GNB1(2), GNGT1(4), HRAS(2), ITGA1(10), ITGB1(12), MAP2K1(9), MAPK1(4), MAPK3(3), PLA2G4A(8), PLCB1(24), PRKCA(9), PTGS1(15), PTK2(12), RAF1(11), SRC(5), SYK(11), TBXAS1(9)	20968990	185	115	177	49	60	19	20	51	34	1	0.0490	1.000	1.000
389	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(6), ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), FPGT(12), GCK(10), GMDS(2), GMPPA(8), GMPPB(6), HK1(18), HK2(15), HK3(13), KHK(2), MPI(3), PFKFB1(8), PFKFB3(10), PFKFB4(6), PFKM(6), PFKP(23), PMM1(4), PMM2(3), SORD(3), TPI1(3)	20635905	196	114	191	60	73	30	19	35	39	0	0.0661	1.000	1.000
390	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(7), BCL2(4), EGFR(24), IGF1R(24), MYC(6), POLR2A(27), PPP2CA(5), PRKCA(9), RB1(22), TEP1(39), TERF1(10), TERT(11), TNKS(23), XRCC5(14)	23538909	225	114	216	89	57	35	38	38	57	0	0.792	1.000	1.000
391	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(7), EIF4A1(4), EIF4A2(8), EIF4B(5), EIF4E(2), EIF4EBP1(5), EIF4G1(31), EIF4G2(1), EIF4G3(26), FKBP1A(2), MKNK1(6), PDK2(2), PDPK1(1), PIK3R1(17), PPP2CA(5), RPS6(1), RPS6KB1(6), TSC1(20), TSC2(21)	21281635	170	112	164	41	39	15	29	35	50	2	0.101	1.000	1.000
392	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(26), ADRB2(9), GNAS(54), PLCE1(27), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RAP2B(1)	12733333	161	112	151	55	61	21	13	34	31	1	0.550	1.000	1.000
393	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(18), BST1(4), CD38(7), ENPP1(12), ENPP3(16), NADK(13), NADSYN1(13), NMNAT1(6), NMNAT2(3), NMNAT3(3), NNMT(5), NNT(12), NT5C1A(9), NT5C1B(14), NT5C2(9), NT5E(5), NT5M(7), NUDT12(7)	18537128	163	111	153	53	34	25	20	35	48	1	0.461	1.000	1.000
394	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(5), ASNS(10), ASRGL1(6), CA1(4), CA12(1), CA13(4), CA14(7), CA2(7), CA3(5), CA4(8), CA5A(4), CA5B(1), CA6(4), CA7(4), CA8(4), CA9(7), CPS1(35), CTH(3), GLS(13), GLS2(8), GLUD1(5), GLUD2(17), GLUL(7), HAL(5)	18255218	174	111	167	52	33	25	30	48	38	0	0.306	1.000	1.000
395	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), IGF1(3), IGF1R(24), IRS1(33), JUN(6), MAP2K1(9), MAPK3(3), MAPK8(7), PIK3R1(17), PTPN11(10), RAF1(11), RASA1(28), SHC1(7), SOS1(12), SRF(5)	19469262	195	111	182	53	44	23	23	43	59	3	0.173	1.000	1.000
396	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(3), CALM3(2), CAMK1(4), CAMK1G(10), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), ESRRA(4), HDAC5(15), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), PPARA(8), PPP3CA(14), PPP3CB(8), PPP3CC(9), SLC2A4(5), SYT1(8), YWHAH(3)	17568698	159	111	153	37	41	18	17	40	43	0	0.0125	1.000	1.000
397	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(11), CSF1R(26), EGF(15), EGFR(24), GRB2(4), MET(14), PDGFRA(17), PRKCA(9), SH3GLB1(5), SH3GLB2(10), SH3KBP1(22), SRC(5)	16718842	162	110	152	62	36	27	11	45	43	0	0.840	1.000	1.000
398	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(26), ADRB2(9), CFTR(23), GNAS(54), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), SLC9A3R1(4)	11269526	160	110	150	42	56	15	11	39	38	1	0.238	1.000	1.000
399	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(6), CSF1R(26), DDX20(4), E2F1(6), E2F4(2), ETS1(9), ETS2(4), ETV3(4), FOS(2), HDAC2(6), HDAC5(15), HRAS(2), JUN(6), NCOR2(52), RBL1(14), RBL2(11), SIN3A(20), SIN3B(18)	22638857	207	110	204	50	55	21	25	51	52	3	0.0649	1.000	1.000
400	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH3B1(6), ALDH3B2(7), ALDH9A1(7), AOC2(14), AOC3(18), ASPA(4), CNDP1(5), DDC(14), HAL(5), HARS(10), HDC(13), HNMT(3), MAOA(6), MAOB(6), PRPS1(4), PRPS2(5)	20995725	205	110	187	51	52	17	21	49	65	1	0.158	1.000	1.000
401	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(17), ABCC2(23), ABCG2(11), BCHE(28), CES1(21), CES2(10), CYP3A4(3), CYP3A5(3), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5)	19674377	167	110	159	36	33	25	18	41	50	0	0.0200	1.000	1.000
402	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(10), CREBBP(59), EP300(39), FADD(4), HDAC3(10), IKBKB(12), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF6(7)	19097195	179	110	172	47	46	25	19	38	51	0	0.0787	1.000	1.000
403	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	28	AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(10), AGPAT6(7), AGPS(10), CHPT1(4), ENPP2(11), ENPP6(10), PAFAH1B2(1), PAFAH1B3(3), PAFAH2(5), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), PLD1(26), PLD2(22), PPAP2A(5), PPAP2B(5), PPAP2C(6)	19125681	184	109	180	47	53	26	32	43	30	0	0.0246	1.000	1.000
404	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(5), BLVRA(7), BLVRB(1), CP(13), CPOX(5), EPRS(21), FECH(8), GUSB(12), HCCS(6), HMBS(4), HMOX1(8), HMOX2(1), PPOX(10), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2B15(6), UGT2B4(6), UROD(3), UROS(6)	23481006	173	109	168	50	37	25	20	47	44	0	0.247	1.000	1.000
405	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(7), AP2A1(15), AP2M1(8), ARF1(6), BAD(4), BTK(5), EEA1(17), GRASP(3), GSK3A(6), GSK3B(9), LYN(9), PDPK1(1), PFKL(9), PFKM(6), PFKP(23), PLCG1(27), PRKCE(16), PRKCZ(4), RAB5A(4), RAC1(2), RPS6KB1(6), VAV2(14)	21686436	201	109	195	60	66	32	24	34	44	1	0.134	1.000	1.000
406	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ACAA2(13), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(6), ADHFE1(11), AKR1C4(7), AKR1D1(4), ALDH1A1(10), ALDH1A2(9), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH9A1(7), BAAT(6), CEL(20), CYP27A1(8), CYP7A1(7), HADHB(6), SOAT2(4), SRD5A1(2)	19967849	199	108	184	57	43	24	31	44	57	0	0.206	1.000	1.000
407	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), IL6(1), IL6R(4), IL6ST(11), JAK1(22), JAK2(14), JAK3(18), JUN(6), MAP2K1(9), MAPK3(3), PTPN11(10), RAF1(11), SHC1(7), SOS1(12), SRF(5), STAT3(9)	20643189	162	108	153	48	33	24	18	52	32	3	0.328	1.000	1.000
408	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(6), ARSB(4), ARSD(6), ARSE(6), ASAH1(4), GAL3ST1(14), GALC(5), GBA(14), GLA(3), GLB1(9), LCT(32), NEU1(4), NEU2(9), NEU3(5), NEU4(7), PPAP2A(5), PPAP2B(5), PPAP2C(6), SMPD1(8), SMPD2(3), SPTLC1(6), SPTLC2(8), UGCG(4)	20752315	173	107	169	67	52	23	29	33	36	0	0.734	1.000	1.000
409	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(8), GPLD1(15), PGAP1(12), PIGA(3), PIGB(11), PIGC(6), PIGG(16), PIGK(5), PIGL(5), PIGM(4), PIGN(12), PIGO(13), PIGP(1), PIGQ(14), PIGS(8), PIGT(15), PIGV(7), PIGW(6), PIGX(3), PIGZ(11)	20669751	175	107	161	52	37	18	21	50	48	1	0.425	1.000	1.000
410	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(6), BCAT2(11), COASY(5), DPYD(25), DPYS(12), ENPP1(12), ENPP3(16), ILVBL(9), PANK1(14), PANK2(10), PANK3(6), PANK4(9), PPCDC(2), PPCS(2), UPB1(6), VNN1(8)	14984422	153	107	148	31	32	20	21	48	32	0	0.00330	1.000	1.000
411	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(5), BIRC2(8), BIRC3(12), CASP3(2), CFLAR(3), FADD(4), JUN(6), MAP2K4(12), MAP3K3(10), MAP3K7(14), NFKB1(10), NFKB2(11), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR2C2(10), RALBP1(12), RIPK1(5), TNF(3), TNFAIP3(16), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF2(5)	22578618	175	107	171	41	44	23	17	41	47	3	0.0472	1.000	1.000
412	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(10), CREB1(4), CREBBP(59), EP300(39), NCOA3(18), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12), RARA(4), RXRA(13)	17701360	191	106	182	56	51	25	23	35	57	0	0.190	1.000	1.000
413	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(5), EPHA4(21), EPHB1(41), FYN(10), ITGA1(10), ITGB1(12), L1CAM(22), LYN(9), RAP1B(6), SELP(14)	13532143	150	106	144	53	51	19	17	46	16	1	0.332	1.000	1.000
414	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(3), ATG3(1), ATG5(6), ATG7(13), BECN1(9), GABARAPL1(6), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(5), IFNA17(4), IFNA2(3), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(5), IFNA8(1), IFNG(3), PIK3C3(17), PIK3R4(10), PRKAA1(9), PRKAA2(11), ULK1(23), ULK2(13), ULK3(5)	18212932	163	106	154	44	28	22	23	52	37	1	0.258	1.000	1.000
415	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(6), ANXA2(4), ANXA3(1), ANXA4(8), ANXA5(7), ANXA6(4), CYP11A1(8), EDN1(4), EDNRA(5), HPGD(3), HSD11B1(5), HSD11B2(5), PLA2G4A(8), PRL(3), PTGDR(8), PTGDS(3), PTGER2(8), PTGER4(15), PTGFR(6), PTGIR(2), PTGIS(10), PTGS1(15), PTGS2(7), S100A6(1), SCGB1A1(3), TBXAS1(9)	16924488	158	106	155	55	39	13	23	49	33	1	0.648	1.000	1.000
416	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(32), APOA1(9), APOA4(9), APOC2(3), APOC3(3), APOE(3), CETP(7), CYP7A1(7), DGAT1(10), HMGCR(8), LCAT(5), LDLR(15), LIPC(5), LPL(11), LRP1(62), SCARB1(7), SOAT1(12)	23560633	208	106	199	63	72	23	28	41	42	2	0.150	1.000	1.000
417	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(5), CHUK(10), CRADD(7), IKBKB(12), JUN(6), LTA(4), MAP2K3(11), MAP2K4(12), MAP2K6(1), MAP3K1(24), MAP4K2(14), MAPK14(3), MAPK8(7), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), TANK(6), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(5)	20727757	161	106	156	47	35	20	20	32	52	2	0.288	1.000	1.000
418	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(6), CR1(35), CR2(29), FCGR2B(4), HLA-DRA(7), HLA-DRB1(2), ICAM1(5), ITGAL(28), ITGB2(12), PTPRC(30)	13106191	158	105	139	43	36	19	18	39	46	0	0.156	1.000	1.000
419	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(8), FUCA1(2), FUCA2(5), GLB1(9), HEXA(2), HEXB(3), LCT(32), MAN2B1(23), MAN2B2(25), MAN2C1(15), MANBA(11), NEU1(4), NEU2(9), NEU3(5), NEU4(7)	17466524	160	105	156	42	48	26	19	33	34	0	0.0480	1.000	1.000
420	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), IL2RA(3), IL2RB(3), IL2RG(12), JAK1(22), JAK3(18), JUN(6), LCK(5), MAP2K1(9), MAPK3(3), MAPK8(7), RAF1(11), SHC1(7), SOS1(12), STAT5A(13), STAT5B(15), SYK(11)	20237673	177	105	166	40	39	26	17	50	43	2	0.0319	1.000	1.000
421	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(11), ATM(71), BAX(3), BCL2(4), CCND1(3), CCNE1(7), CDK2(5), CDK4(2), CDKN1A(7), E2F1(6), MDM2(10), PCNA(2), RB1(22)	14628012	153	105	143	30	25	24	19	34	47	4	0.0217	1.000	1.000
422	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(7), AKR1D1(4), ARSB(4), ARSD(6), ARSE(6), CYP11B1(19), CYP11B2(12), HSD11B1(5), HSD11B2(5), HSD17B2(3), HSD17B3(2), HSD3B1(6), HSD3B2(5), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2B15(6), UGT2B4(6)	23382587	164	104	158	63	41	31	19	42	31	0	0.658	1.000	1.000
423	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(7), CARM1(10), CBS(9), CTH(3), GGT1(9), HEMK1(2), LCMT1(2), LCMT2(11), MARS(10), MARS2(6), MAT1A(8), MAT2B(5), METTL2B(1), METTL6(5), PAPSS1(6), PAPSS2(9), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), SCLY(6), SEPHS1(7), SEPHS2(5), WBSCR22(5)	21528119	173	104	165	52	41	26	26	33	46	1	0.154	1.000	1.000
424	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(14), ACE2(14), AGT(5), AGTR1(1), AGTR2(6), ANPEP(11), CMA1(3), CPA3(6), CTSA(5), CTSG(4), ENPEP(19), LNPEP(15), MAS1(4), MME(14), NLN(10), REN(9), THOP1(7)	18109382	147	103	144	55	36	19	19	38	35	0	0.764	1.000	1.000
425	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(26), CREM(6), FHL5(7), FSHB(1), FSHR(30), GNAS(54), XPO1(17)	8265301	141	102	125	33	52	19	10	43	16	1	0.127	1.000	1.000
426	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(23), POLR1B(11), POLR1C(9), POLR1D(4), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLR3A(31), POLR3B(16), POLR3G(3), POLR3H(2), POLR3K(2), ZNRD1(2)	20104287	162	102	157	46	47	18	26	36	35	0	0.152	1.000	1.000
427	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(5), C1QB(3), C1R(1), C1S(11), C2(4), C3(43), C5(15), C6(19), C7(11), C8A(13), C9(10), MASP1(7), MASP2(6), MBL2(8)	18428398	156	101	149	40	41	21	14	44	36	0	0.0899	1.000	1.000
428	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(4), GALNS(4), GLB1(9), GNS(10), GUSB(12), HEXA(2), HEXB(3), HGSNAT(8), HPSE(11), HPSE2(13), HYAL1(7), HYAL2(10), IDS(4), IDUA(5), LCT(32), NAGLU(11), SPAM1(11)	17729557	156	101	154	50	43	28	22	33	30	0	0.317	1.000	1.000
429	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(8), CCR2(6), CCR3(14), CCR4(3), CCR5(5), CCR7(5), CD28(2), CD4(11), CXCR3(3), CXCR4(1), IFNG(3), IFNGR1(11), IFNGR2(2), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL18R1(7), IL4(4), IL4R(10), TGFB1(3), TGFB2(10), TGFB3(11)	17211185	150	101	140	52	35	12	20	45	38	0	0.734	1.000	1.000
430	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(4), BAX(3), BCL2(4), FADD(4), MAP2K1(9), MAP2K4(12), MAP3K1(24), MAPK1(4), MAPK3(3), MAPK8(7), NFKB1(10), NSMAF(14), RAF1(11), RELA(7), RIPK1(5), SMPD1(8), TNFRSF1A(6), TRADD(2), TRAF2(5)	16548031	142	99	133	42	44	22	11	23	39	3	0.162	1.000	1.000
431	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(15), EGFR(24), MAP2K1(9), MAP3K1(24), MAPK14(3), NCOR2(52), RARA(4), RXRA(13), THRA(13), THRB(5)	14919433	162	99	153	50	58	21	15	33	32	3	0.259	1.000	1.000
432	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(6), ELK1(6), EPO(3), EPOR(5), FOS(2), GRB2(4), HRAS(2), JAK2(14), JUN(6), MAP2K1(9), MAPK3(3), MAPK8(7), PLCG1(27), PTPN6(6), RAF1(11), SHC1(7), SOS1(12), STAT5A(13), STAT5B(15)	18695160	158	99	153	41	46	25	17	36	33	1	0.0553	1.000	1.000
433	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	18	AP2A1(15), AP2M1(8), BIN1(8), CALM1(2), CALM2(3), CALM3(2), DNM1(10), EPN1(12), EPS15(5), NME2(3), PICALM(6), PPP3CA(14), PPP3CB(8), PPP3CC(9), SYNJ1(18), SYNJ2(24), SYT1(8)	17804018	155	99	144	31	41	17	14	36	46	1	0.00311	1.000	1.000
434	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(5), C1QB(3), C1R(1), C1S(11), C2(4), C3(43), C5(15), C6(19), C7(11), C8A(13), C8B(14), C9(10), MASP1(7)	17965300	156	98	149	37	43	19	16	45	33	0	0.0503	1.000	1.000
435	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(23), IL13(4), IL4(4), JUNB(5), MAF(5), MAP2K3(11), MAPK14(3), NFATC1(20), NFATC2(32), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12)	10366845	151	98	142	49	52	22	13	21	43	0	0.140	1.000	1.000
436	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(12), RPE(6), UGDH(11), UGP2(9), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2A1(6), UGT2A3(8), UGT2B10(6), UGT2B11(3), UGT2B15(6), UGT2B17(7), UGT2B28(12), UGT2B4(6), UGT2B7(7), XYLB(7)	23264279	164	98	155	35	24	17	29	45	49	0	0.0422	1.000	1.000
437	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(6), BCAT2(11), IARS(15), IARS2(13), ILVBL(9), LARS(13), LARS2(12), PDHA1(1), PDHA2(16), PDHB(4), VARS(25), VARS2(16)	15945959	141	98	139	47	40	18	19	38	26	0	0.505	1.000	1.000
438	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(8), B3GNT2(6), B3GNT7(7), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT4(7), CHST1(21), CHST2(15), CHST4(7), CHST6(13), FUT8(11), ST3GAL1(7), ST3GAL2(11), ST3GAL3(3), ST3GAL4(8)	10625277	143	98	138	50	63	13	17	29	21	0	0.457	1.000	1.000
439	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	AKR1B10(6), ALOX15(12), ALOX5(15), CYP1A2(6), CYP2C18(8), CYP2C19(8), CYP2C8(2), CYP2C9(5), CYP2E1(8), CYP2J2(5), CYP3A4(3), CYP3A43(6), CYP3A5(3), CYP3A7(5), HSD3B7(9), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11), RDH11(1), RDH12(3), RDH13(8)	20544258	161	98	159	52	55	18	25	39	23	1	0.321	1.000	1.000
440	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(18), AMT(5), ATIC(7), FTCD(9), GART(12), MTFMT(3), MTHFD1(9), MTHFD1L(12), MTHFD2(3), MTHFR(12), MTHFS(3), MTR(26), SHMT1(4), SHMT2(13), TYMS(3)	16302903	139	98	133	39	31	19	22	33	33	1	0.0989	1.000	1.000
441	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(6), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT5(5), DDOST(1), DPAGT1(6), DPM1(2), FUT8(11), MAN1A1(6), MAN1B1(8), MGAT1(6), MGAT2(4), MGAT3(13), MGAT4A(6), MGAT4B(6), MGAT5(14), RPN1(7), RPN2(9), ST6GAL1(1)	17049742	134	98	131	46	38	17	14	35	30	0	0.523	1.000	1.000
442	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(59), EP300(39), ESR1(14), MAPK1(4), MAPK3(3), PELP1(11), SRC(5)	12564375	135	98	129	30	41	13	19	29	33	0	0.0181	1.000	1.000
443	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(11), ALDOC(11), DERA(2), FBP1(4), FBP2(8), G6PD(6), GPI(6), H6PD(8), PFKL(9), PFKM(6), PFKP(23), PGD(9), PGLS(3), PGM1(4), PGM3(13), PRPS1(4), PRPS2(5), RBKS(4), RPE(6), RPIA(3), TALDO1(6), TKT(6), TKTL1(12), TKTL2(12)	20891283	182	97	174	54	44	35	20	48	35	0	0.0724	1.000	1.000
444	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(4), CAT(6), EPX(18), LPO(14), MPO(12), MTHFR(12), PRDX6(5), SHMT1(4), SHMT2(13), TPO(35)	9966185	123	97	118	33	37	16	9	30	30	1	0.133	1.000	1.000
445	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(4), ATP6V0C(2), CAT(6), EPX(18), LPO(14), MPO(12), PRDX1(3), PRDX2(3), PRDX6(5), SHMT1(4), SHMT2(13), TPO(35)	10172507	119	97	114	34	32	16	10	32	28	1	0.196	1.000	1.000
446	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(9), ACO2(12), CS(1), DLD(14), DLST(6), FH(4), IDH1(5), IDH2(8), IDH3A(3), IDH3B(3), IDH3G(7), MDH1(5), MDH2(2), PC(19), PCK1(14), SDHA(15), SDHB(4), SUCLA2(3), SUCLG1(4), SUCLG2(9)	17756425	147	96	140	38	48	26	13	23	37	0	0.0404	1.000	1.000
447	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(5), ASNS(10), CA1(4), CA12(1), CA14(7), CA2(7), CA3(5), CA4(8), CA5A(4), CA5B(1), CA6(4), CA7(4), CA8(4), CA9(7), CPS1(35), CTH(3), GLS(13), GLS2(8), GLUD1(5), GLUL(7), HAL(5)	16350697	147	96	140	46	25	21	27	39	35	0	0.481	1.000	1.000
448	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(10), F2(15), F2R(10), F3(2), F5(26), F7(12), FGA(16), FGB(9), FGG(6), PROC(5), PROS1(16), SERPINC1(5), TFPI(7)	14126379	139	95	137	35	35	19	18	43	24	0	0.0912	1.000	1.000
449	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(6), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7), CYP2C19(8), CYP2C9(5), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), ECHS1(3), EHHADH(5), ESCO1(13), ESCO2(11), HADHA(7), NAT6(4), PNPLA3(4), SH3GLB1(5), YOD1(2)	26357634	164	95	150	44	39	15	18	36	56	0	0.350	1.000	1.000
450	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(10), DUSP1(3), IKBKAP(20), IKBKB(12), LTA(4), MAP3K1(24), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), TANK(6), TNFAIP3(16), TNFRSF1B(4), TRAF1(6), TRAF2(5), TRAF3(8)	19228579	141	95	135	43	38	17	13	30	42	1	0.428	1.000	1.000
451	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(7), CREB1(4), MAP2K1(9), MAP2K2(6), MAP2K3(11), MAP2K6(1), MAP3K1(24), MAPK1(4), MAPK14(3), MAPK3(3), NFKB1(10), PIK3R1(17), RB1(22), RELA(7), SP1(6)	14901467	134	94	126	43	24	16	22	21	50	1	0.555	1.000	1.000
452	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(8), IL22(2), IL22RA1(4), IL22RA2(2), JAK1(22), JAK2(14), JAK3(18), SOCS3(4), STAT1(14), STAT3(9), STAT5A(13), STAT5B(15), TYK2(15)	15971100	140	94	134	44	35	17	15	32	38	3	0.561	1.000	1.000
453	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(10), FADD(4), IKBKB(12), IL1A(2), IL1R1(5), IRAK1(9), MAP3K1(24), MAP3K7(14), MYD88(4), NFKB1(10), NFKBIA(1), RELA(7), RIPK1(5), TNF(3), TNFAIP3(16), TNFRSF1A(6), TNFRSF1B(4), TRADD(2), TRAF6(7)	19378106	145	94	138	39	38	19	14	28	46	0	0.156	1.000	1.000
454	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(7), AMD1(8), BHMT(8), CBS(9), CTH(3), DNMT1(21), DNMT3A(11), DNMT3B(16), MARS(10), MARS2(6), MAT1A(8), MAT2B(5), MTAP(4), MTFMT(3), MTR(26), SRM(4), TAT(7)	17870881	156	93	154	64	44	21	27	36	28	0	0.809	1.000	1.000
455	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(8), B3GNT2(6), B3GNT3(3), B3GNT4(9), B3GNT5(12), B4GALT1(6), B4GALT2(9), B4GALT3(4), B4GALT4(7), FUT1(6), FUT2(2), FUT3(6), FUT4(3), FUT5(4), FUT6(8), FUT7(4), FUT9(11), GCNT2(1), ST3GAL6(7), ST8SIA1(12)	13797759	128	93	121	42	36	16	15	34	27	0	0.509	1.000	1.000
456	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(10), GALNT2(9), GALNT3(6), GALNT4(6), GALNT6(7), GALNT7(4), GALNT8(12), GALNT9(6), GCNT1(4), ST3GAL1(7), ST3GAL2(11), ST3GAL4(8), WBSCR17(37)	12516894	131	93	126	48	47	9	17	37	20	1	0.843	1.000	1.000
457	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(7), CCND1(3), CCNE1(7), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN1B(1), E2F1(6), HRAS(2), MAPK1(4), MAPK3(3), NFKB1(10), NFKBIA(1), PAK1(7), PIK3R1(17), RAC1(2), RAF1(11), RB1(22), RELA(7), TFDP1(6)	15581417	136	93	132	38	22	21	20	24	48	1	0.214	1.000	1.000
458	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(15), AGT(5), AGTR2(6), EDN1(4), EDNRA(5), EGF(15), EGFR(24), FOS(2), HRAS(2), JUN(6), MYC(6), NFKB1(10), PLCG1(27), PRKCA(9), RELA(7)	16844502	143	92	139	43	39	25	13	37	29	0	0.138	1.000	1.000
459	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(11), ARHGDIB(1), BIRC2(8), BIRC3(12), CASP1(8), CASP10(8), CASP2(5), CASP3(2), CASP4(7), CASP6(2), CASP7(5), CASP9(4), DFFA(5), DFFB(5), GZMB(2), LMNA(13), LMNB1(5), LMNB2(11), PRF1(17)	15572000	131	92	128	36	33	16	18	31	33	0	0.263	1.000	1.000
460	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(9), B4GALNT1(7), GLB1(9), HEXA(2), HEXB(3), LCT(32), SLC33A1(7), ST3GAL1(7), ST3GAL2(11), ST3GAL5(3), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(11), ST6GALNAC6(5), ST8SIA1(12), ST8SIA5(8)	14048670	136	92	133	54	50	15	19	29	23	0	0.770	1.000	1.000
461	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), GOT1(3), GOT2(2), GPT(8), GPT2(4), MDH1(5), MDH2(2), ME1(2), ME3(8), PGK1(5), PGK2(4), PKLR(12), RPE(6), RPIA(3), TKT(6), TKTL1(12), TKTL2(12), TPI1(3)	17245746	132	92	131	66	37	27	13	31	24	0	0.963	1.000	1.000
462	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(9), ACP2(6), ACP5(4), ACP6(3), ACPP(8), ACPT(6), ENPP1(12), ENPP3(16), FLAD1(6), LHPP(4), MTMR1(8), MTMR2(10), MTMR6(14), PHPT1(2), RFK(3), TYR(18)	12977092	129	92	119	32	20	21	21	31	36	0	0.107	1.000	1.000
463	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(18), AMT(5), ATIC(7), ATP6V0C(2), GART(12), MTHFD1(9), MTHFD1L(12), MTHFD2(3), MTHFR(12), MTHFS(3), MTR(26), SHMT1(4), SHMT2(13), TYMS(3)	15409200	129	92	124	32	28	19	22	30	29	1	0.0218	1.000	1.000
464	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(8), ICAM1(5), ITGA4(21), ITGAL(28), ITGAM(13), ITGB1(12), ITGB2(12), SELE(9), SELL(7), SELP(14)	13820302	129	91	123	48	38	11	14	36	30	0	0.510	1.000	1.000
465	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(8), HSPA1A(4), IFNG(3), IFNGR1(11), IFNGR2(2), IKBKB(12), JAK2(14), LIN7A(11), NFKB1(10), NFKBIA(1), RB1(22), RELA(7), TNF(3), TNFRSF1A(6), TNFRSF1B(4), USH1C(8), WT1(9)	15020540	135	91	132	50	31	19	13	31	40	1	0.798	1.000	1.000
466	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), GOT1(3), GOT2(2), GPT(8), GPT2(4), MDH1(5), MDH2(2), ME1(2), ME2(10), ME3(8), PGK1(5), PKLR(12), RPE(6), RPIA(3), TKT(6), TPI1(3)	15441181	114	90	114	53	30	23	11	26	24	0	0.896	1.000	1.000
467	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(5), C1QB(3), C1R(1), C1S(11), C2(4), C3(43), C5(15), C6(19), C7(11), C8A(13), C9(10)	15129497	135	90	128	34	37	19	14	37	28	0	0.0978	1.000	1.000
468	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(6), AOC2(14), AOC3(18), CES1(21), DDHD1(17), ESCO1(13), ESCO2(11), LIPA(3), NAT6(4), PLA1A(4), PNPLA3(4), PPME1(2), PRDX6(5), SH3GLB1(5)	21663035	127	90	120	16	29	12	10	28	48	0	0.00200	1.000	1.000
469	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(6), ELK1(6), FOS(2), GRB2(4), HRAS(2), JUN(6), KLK2(2), MAP2K1(9), MAPK3(3), MAPK8(7), NGFR(9), PIK3R1(17), PLCG1(27), RAF1(11), SHC1(7), SOS1(12)	14584217	130	90	124	30	39	14	15	32	29	1	0.0317	1.000	1.000
470	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(11), BIRC2(8), BIRC3(12), CASP10(8), CASP3(2), CASP7(5), CASP9(4), DFFA(5), DFFB(5), GZMB(2), PRF1(17), SCAP(18), SREBF1(18), SREBF2(17)	14590418	132	90	127	30	40	15	14	34	29	0	0.0496	1.000	1.000
471	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(7), AKT2(11), AKT3(10), CDKN1A(7), ELK1(6), GRB2(4), HRAS(2), MAP2K1(9), MAP2K2(6), NGFR(9), NTRK1(14), PIK3CD(20), SHC1(7), SOS1(12)	12190282	124	90	118	45	43	18	11	38	14	0	0.487	1.000	1.000
472	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(18), LPO(14), MPO(12), PRDX1(3), PRDX2(3), PRDX6(5), TPO(35), TYR(18)	8317554	108	90	103	34	29	15	9	37	17	1	0.409	1.000	1.000
473	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(12), E2F1(6), MDM2(10), MYC(6), PIK3R1(17), POLR1A(23), POLR1B(11), POLR1C(9), POLR1D(4), RAC1(2), RB1(22), TBX2(12), TWIST1(5)	14371353	139	89	132	42	30	11	18	25	53	2	0.466	1.000	1.000
474	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(13), CCNB1(4), CCND1(3), CCND2(2), CCND3(1), CCNE1(7), CCNH(3), CDC25A(8), CDK2(5), CDK4(2), CDK6(6), CDKN1A(7), CDKN1B(1), CDKN2B(1), CDKN2C(2), CDKN2D(5), E2F1(6), RB1(22), RBL1(14), TFDP1(6)	13406909	118	89	115	34	18	22	16	28	34	0	0.238	1.000	1.000
475	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(8), POLD1(18), POLD2(8), POLE(42), POLG(10), POLL(4), POLQ(46)	14379250	136	89	133	53	35	22	11	27	41	0	0.903	1.000	1.000
476	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(7), CREB1(4), GRB2(4), HRAS(2), MAPK1(4), MAPK3(3), MAPK7(9), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), NTRK1(14), PIK3R1(17), PLCG1(27), RPS6KA1(10), SHC1(7)	14591451	135	89	131	38	42	20	17	22	33	1	0.107	1.000	1.000
477	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(11), ALDOC(11), FBP1(4), FBP2(8), G6PD(6), GPI(6), H6PD(8), PFKM(6), PFKP(23), PGD(9), PGLS(3), PGM1(4), PGM3(13), PRPS1(4), PRPS2(5), RBKS(4), RPE(6), RPIA(3), TAL1(5), TALDO1(6), TKT(6)	17500422	152	89	145	43	36	29	16	41	30	0	0.0565	1.000	1.000
478	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(4), JAK1(22), JAK2(14), JAK3(18), PIAS1(17), PIAS3(11), PTPRU(33), REG1A(5), SOAT1(12)	11886031	136	89	120	34	35	17	12	27	42	3	0.228	1.000	1.000
479	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(4), CHUK(10), IFNG(3), IKBKB(12), IL4(4), JUN(6), MAP3K1(24), MAP3K5(18), MAP4K5(10), MAPK14(3), MAPK8(7), NFKB1(10), NFKBIA(1), RELA(7), TNFRSF9(12), TNFSF9(2), TRAF2(5)	16755679	138	88	128	31	31	15	12	31	48	1	0.118	1.000	1.000
480	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(6), ARFGAP1(5), ARFGAP3(6), ARFGEF2(37), CLTA(2), CLTB(2), COPA(21), GBF1(27), GPLD1(15), KDELR1(3), KDELR2(5), KDELR3(2)	13983485	131	88	129	36	38	20	20	31	22	0	0.0965	1.000	1.000
481	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(36), ACACB(49), FASN(34), MCAT(3), OLAH(1), OXSM(7)	13713503	130	87	125	36	37	18	17	32	25	1	0.0917	1.000	1.000
482	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(11), G6PD(6), GCLC(4), GCLM(4), GGT1(9), GPX5(2), GPX7(4), GSR(8), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(3), GSTK1(3), GSTM2(1), GSTM3(3), GSTM4(3), GSTM5(3), GSTO2(4), GSTP1(2), GSTZ1(2), IDH1(5), IDH2(8), MGST1(3), MGST2(3), MGST3(5), OPLAH(28), TXNDC12(3)	18995215	138	87	129	44	37	23	12	31	34	1	0.489	1.000	1.000
483	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(7), BAD(4), CHRNB1(10), CHRNG(11), MUSK(18), PIK3R1(17), PTK2(12), PTK2B(20), RAPSN(5), SRC(5), TERT(11), YWHAH(3)	12287650	123	86	120	42	39	13	15	24	31	1	0.436	1.000	1.000
484	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(7), CYB5R3(4), GCK(10), GFPT1(9), GNE(12), GNPDA1(4), GNPDA2(7), HEXA(2), HEXB(3), HK1(18), HK2(15), HK3(13), PGM3(13), RENBP(5), UAP1(6)	14622238	128	86	124	32	43	21	17	30	17	0	0.0231	1.000	1.000
485	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(9), ACP2(6), ACP5(4), ACP6(3), ACPP(8), ACPT(6), ALPI(7), ALPL(10), ALPP(16), ALPPL2(6), CYP3A4(3), CYP3A43(6), CYP3A5(3), CYP3A7(5), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), PON1(4), PON2(5), PON3(9)	15530098	133	86	125	51	41	14	14	30	34	0	0.715	1.000	1.000
486	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(13), B3GAT2(9), B3GAT3(4), B4GALT7(9), CHPF(8), CHST11(4), CHST12(7), CHST13(6), CHST14(3), CHST3(10), CHST7(8), CHSY1(12), DSE(11), UST(10), XYLT1(14)	10701476	128	86	122	54	63	12	16	24	13	0	0.760	1.000	1.000
487	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(3), MRPS7(1), RPL10A(7), RPL11(3), RPL12(3), RPL13(1), RPL13A(5), RPL14(2), RPL18(1), RPL18A(2), RPL19(1), RPL22L1(1), RPL23A(3), RPL24(2), RPL26(2), RPL27(1), RPL28(2), RPL29(2), RPL3(5), RPL30(1), RPL31(3), RPL32(1), RPL34(2), RPL35(1), RPL35A(1), RPL36A(3), RPL36AL(1), RPL37(1), RPL37A(1), RPL38(2), RPL3L(4), RPL6(4), RPL8(5), RPL9(4), RPS10(2), RPS11(3), RPS13(4), RPS16(1), RPS18(1), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(2), RPS26(3), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(5), RPS6(1), RPS7(1), RPS9(3), RPSA(5)	19343271	125	86	121	48	28	17	15	31	34	0	0.973	1.000	1.000
488	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(7), EIF2B5(11), EIF2S1(3), EIF2S2(3), EIF2S3(3), EIF4E(2), EIF4EBP1(5), GSK3B(9), IGF1(3), IGF1R(24), INPPL1(29), PDK2(2), PDPK1(1), PIK3R1(17), PPP2CA(5), RPS6(1), RPS6KB1(6)	14426059	131	86	121	42	33	10	22	22	42	2	0.659	1.000	1.000
489	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(7), BAD(4), GRB2(4), HRAS(2), IGF1R(24), IRS1(33), MAP2K1(9), MAPK1(4), MAPK3(3), PIK3R1(17), RAF1(11), SHC1(7), SOS1(12), YWHAH(3)	14431383	140	86	132	49	37	18	20	25	38	2	0.701	1.000	1.000
490	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(7), AKT2(11), AKT3(10), BPNT1(6), GRB2(4), ILK(11), MAPK1(4), MAPK3(3), PDK1(3), PIK3CD(20), PTK2B(20), RBL2(11), SHC1(7), SOS1(12)	14887938	129	86	125	39	41	17	11	31	29	0	0.525	1.000	1.000
491	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(4), IL6(1), IL6R(4), JAK1(22), JAK2(14), JAK3(18), PIAS3(11), PTPRU(33), REG1A(5), SRC(5), STAT3(9)	13163867	126	86	118	35	35	17	11	26	34	3	0.244	1.000	1.000
492	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(15), EGFR(24), ERBB3(49), NRG1(24), UBE2D1(1)	8853169	113	85	102	34	35	21	14	33	10	0	0.172	1.000	1.000
493	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(5), CD3E(3), CXCR3(3), ETV5(9), IFNG(3), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), IL18(1), IL18R1(7), JAK2(14), JUN(6), MAP2K6(1), MAPK14(3), MAPK8(7), STAT4(14), TYK2(15)	16100621	121	85	121	38	22	17	20	32	29	1	0.428	1.000	1.000
494	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(18), CD38(7), ENPP1(12), ENPP3(16), NADSYN1(13), NMNAT1(6), NMNAT2(3), NNMT(5), NNT(12), NT5E(5), NT5M(7)	12500456	104	85	98	38	9	16	14	29	35	1	0.831	1.000	1.000
495	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(11), ALOX15(12), ALOX15B(6), ALOX5(15), ALOX5AP(3), DPEP1(4), GGT1(9), LTA4H(5), PLA2G2A(2), PLA2G6(11), PTGDS(3), PTGES(1), PTGIS(10), PTGS1(15), PTGS2(7), TBXAS1(9)	13183933	123	84	121	32	49	11	11	26	24	2	0.0294	1.000	1.000
496	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(6), ALDH18A1(12), ARG1(3), ARG2(4), ASL(8), CKB(7), CKM(2), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(35), GAMT(2), GATM(5), GLUD1(5), NAGS(2), OAT(6), ODC1(4), OTC(5), PYCR1(3), SMS(6)	15181671	127	84	126	36	33	13	18	39	24	0	0.164	1.000	1.000
497	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(11), CLOCK(8), CRY1(4), CRY2(9), CSNK1D(5), CSNK1E(10), NPAS2(18), NR1D1(11), PER1(11), PER2(20), PER3(18)	14593285	125	83	122	34	41	20	12	24	28	0	0.0741	1.000	1.000
498	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(8), FUCA1(2), FUCA2(5), GLB1(9), HEXA(2), HEXB(3), LCT(32), MAN2C1(15), MANBA(11), NEU1(4), NEU2(9), NEU3(5), NEU4(7)	14179693	112	83	111	39	29	21	12	25	25	0	0.592	1.000	1.000
499	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(7), BAD(4), BCL2L1(2), CASP9(4), CDC42(3), CHUK(10), ELK1(6), H2AFX(1), HRAS(2), MAP2K1(9), MAPK3(3), NFKB1(10), PIK3R1(17), RAC1(2), RAF1(11), RALA(1), RALBP1(12), RALGDS(14), RELA(7)	14392152	125	82	119	36	33	17	17	24	33	1	0.208	1.000	1.000
500	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	20	ANPEP(11), CD2(5), CD33(11), CD5(6), CD7(6), IFNA1(1), IFNB1(4), IFNG(3), IL10(4), IL12A(3), IL12B(3), IL13(4), IL3(3), IL4(4), ITGAX(15), TLR2(9), TLR7(7), TLR9(15)	14405971	114	81	111	45	35	14	13	31	21	0	0.582	1.000	1.000
501	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(18), FOS(2), GRB2(4), HRAS(2), IL3(3), IL3RA(6), JAK2(14), MAP2K1(9), MAPK3(3), PTPN6(6), RAF1(11), SHC1(7), SOS1(12), STAT5A(13), STAT5B(15)	15327294	125	81	120	43	35	19	14	32	24	1	0.511	1.000	1.000
502	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(7), GRB2(4), IL2RG(12), IL4(4), IL4R(10), IRS1(33), JAK1(22), JAK3(18), RPS6KB1(6), SHC1(7), STAT6(10)	12735176	133	81	120	30	26	15	16	24	49	3	0.312	1.000	1.000
503	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(16), CNR2(4), DNMT1(21), MTNR1A(5), MTNR1B(10), PTAFR(4), PTGDR(8), PTGER2(8), PTGER4(15), PTGFR(6), PTGIR(2), TBXA2R(11)	9535405	110	81	106	53	43	15	16	23	13	0	0.781	1.000	1.000
504	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(7), BHMT(8), CBS(9), CTH(3), DNMT1(21), DNMT3A(11), DNMT3B(16), MARS(10), MARS2(6), MAT1A(8), MAT2B(5), MTR(26)	15024210	130	80	128	55	41	17	23	27	22	0	0.796	1.000	1.000
505	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(10), DUSP1(3), IKBKAP(20), IKBKB(12), MAP3K1(24), NFKB1(10), NFKBIA(1), RELA(7), TNFAIP3(16), TRAF3(8), TRAF6(7)	15586811	118	79	112	31	28	13	11	26	40	0	0.323	1.000	1.000
506	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(4), CREM(6), FOS(2), JUN(6), MAPK3(3), OPRK1(19), POLR2A(27), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(10), PRKAR2A(3), PRKAR2B(12)	11036855	111	79	106	32	27	19	16	19	30	0	0.169	1.000	1.000
507	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP27B1(11), CYP51A1(13), DHCR24(4), DHCR7(10), EBP(2), FDFT1(5), FDPS(14), GGCX(6), GGPS1(4), HMGCR(8), HSD17B7(5), IDI1(3), IDI2(4), LSS(16), MVD(2), NQO1(4), NSDHL(4), PMVK(1), SQLE(10), TM7SF2(4), VKORC1(2)	15868168	132	79	126	35	33	15	14	33	37	0	0.251	1.000	1.000
508	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(11), CSF1(6), CSF3(3), HLA-DRA(7), HLA-DRB1(2), IFNA1(1), IFNB1(4), IFNG(3), IL10(4), IL11(3), IL12A(3), IL12B(3), IL13(4), IL15(2), IL1A(2), IL3(3), IL4(4), IL6(1), IL7(2), LTA(4), PDGFA(4), TGFB1(3), TGFB2(10), TGFB3(11), TNF(3)	11522223	103	79	95	34	26	12	12	26	27	0	0.631	1.000	1.000
509	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(9), ACAT2(6), ACOT11(6), ACYP1(2), ACYP2(3), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), ECHS1(3), EHHADH(5), ESCO1(13), ESCO2(11), FN3K(6), GCDH(8), HADHA(7), NAT6(4), PNPLA3(4), SH3GLB1(5), YOD1(2)	22179819	117	78	110	24	22	17	16	19	43	0	0.0666	1.000	1.000
510	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	9	ACACA(36), CPT1A(16), LEP(3), LEPR(18), PRKAA1(9), PRKAA2(11), PRKAB2(6), PRKAG1(6), PRKAG2(8)	11987064	113	78	111	28	30	14	13	32	23	1	0.179	1.000	1.000
511	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(5), CD2(5), CD3E(3), CD4(11), CXCR3(3), IFNG(3), IL12A(3), IL12B(3), IL12RB1(6), IL12RB2(18), JAK2(14), STAT4(14), TYK2(15)	12678267	103	78	98	40	18	14	17	26	27	1	0.874	1.000	1.000
512	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA3(6), PSMA4(4), PSMA5(1), PSMA6(9), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(2), PSMB6(5), PSMB7(1), PSMC2(5), PSMC3(10), PSMD1(15), PSMD11(5), PSMD12(7), PSMD13(2), PSMD2(19), PSMD6(6)	13803137	117	77	116	28	27	15	21	31	23	0	0.112	1.000	1.000
513	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(4), FOS(2), HRAS(2), JUN(6), MAP2K1(9), MAPK1(4), MAPK3(3), MYC(6), NFKB1(10), NFKBIA(1), PLCB1(24), PRKCA(9), RAF1(11), RELA(7), TNF(3)	13346305	101	76	95	25	25	15	10	26	25	0	0.0743	1.000	1.000
514	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(12), DLL1(17), FURIN(8), NOTCH1(51), PSEN1(7)	8182446	95	76	92	33	25	9	10	20	29	2	0.439	1.000	1.000
515	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(7), GRB2(4), HRAS(2), KLK2(2), NTRK1(14), PIK3R1(17), PLCG1(27), PRKCA(9), SHC1(7), SOS1(12)	11546763	101	76	97	23	33	11	12	21	23	1	0.0629	1.000	1.000
516	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(11), ESR1(14), GREB1(35), HSPB1(2), HSPB2(2), MTA1(13), MTA3(5), PDZK1(3), TUBA8(11)	9513617	97	75	93	33	32	15	13	18	19	0	0.258	1.000	1.000
517	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(18), KHK(2), LCT(32), MPI(3), PGM1(4), PYGL(14), PYGM(18), TPI1(3), TREH(3)	11661286	97	74	95	33	37	18	8	17	17	0	0.294	1.000	1.000
518	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(14), ESR2(10), ITPKA(2), PDE1A(10), PDE1B(8), PLCB1(24), PLCB2(9), PRL(3), TRH(5), VIP(9)	9528258	94	74	91	37	30	11	15	25	13	0	0.711	1.000	1.000
519	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(6), ACAD9(9), ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), ESCO1(13), ESCO2(11), NAT6(4), PNPLA3(4), SH3GLB1(5)	21268505	113	73	110	25	25	10	18	26	34	0	0.0820	1.000	1.000
520	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(10), HK1(18), HK2(15), HK3(13), IMPA1(8), IMPA2(2), ISYNA1(5), PGM1(4), PGM3(13), TGDS(7)	10076157	95	72	91	28	31	17	13	25	9	0	0.0844	1.000	1.000
521	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(5), CD28(2), CD3E(3), CD4(11), ICAM1(5), ITGAL(28), ITGB2(12), PTPRC(30), THY1(1)	9656065	97	72	88	43	20	9	11	31	26	0	0.934	1.000	1.000
522	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(5), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), NCK1(7), NCKAP1(17), NTRK1(14), PIR(3), PSMA7(4), RAC1(2), WASF1(11), WASF2(10), WASL(7)	12321369	96	71	93	36	30	10	10	23	22	1	0.720	1.000	1.000
523	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(4), ADH4(2), ADH5(4), ADH6(7), ADH7(6), ADHFE1(11), ALDH1A3(10), ALDH1B1(9), ALDH2(15), ALDH3A1(16), ALDH3A2(9), ALDH7A1(2), ALDH9A1(7)	11370599	106	71	94	30	24	10	14	27	31	0	0.317	1.000	1.000
524	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(7), ACOX3(14), ELOVL2(9), ELOVL5(4), ELOVL6(3), FADS1(3), FADS2(6), FASN(34), HADHA(7), HSD17B12(4), PECR(1), SCD(4)	12482580	99	71	90	39	33	11	12	16	27	0	0.731	1.000	1.000
525	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(6), FUT1(6), FUT2(2), FUT9(11), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(7), ST3GAL2(11), ST3GAL4(8), ST8SIA1(12)	8641063	83	70	80	30	34	7	7	27	8	0	0.487	1.000	1.000
526	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(4), GALNS(4), GLB1(9), GNS(10), GUSB(12), HEXA(2), HEXB(3), IDS(4), IDUA(5), LCT(32), NAGLU(11)	12420516	96	70	95	38	27	16	12	21	20	0	0.726	1.000	1.000
527	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(8), ICAM1(5), ITGA4(21), ITGAL(28), ITGB1(12), ITGB2(12), SELE(9), SELL(7)	10494981	102	70	96	37	28	8	13	28	25	0	0.459	1.000	1.000
528	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(5), CD28(2), CD3E(3), CD8A(4), ICAM1(5), ITGAL(28), ITGB2(12), PTPRC(30), THY1(1)	9188886	90	70	86	37	20	9	12	29	20	0	0.735	1.000	1.000
529	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(10), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), HEMK1(2), LCMT1(2), LCMT2(11), METTL2B(1), METTL6(5), PRMT2(9), PRMT3(11), PRMT5(7), PRMT6(4), PRMT7(8), PRMT8(8), WBSCR22(5)	12853614	106	69	100	24	23	16	14	21	31	1	0.0481	1.000	1.000
530	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(6), B3GALNT1(5), B3GALT5(2), FUT1(6), FUT2(2), FUT9(11), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(7), ST3GAL2(11), ST8SIA1(12)	9155760	82	68	78	36	32	7	7	26	10	0	0.830	1.000	1.000
531	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(12), RPE(6), UCHL1(3), UCHL3(4), UGDH(11), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(12), UGT1A5(5), UGT1A6(11), UGT1A7(6), UGT1A9(5), UGT2B15(6), UGT2B4(6)	15035227	106	68	100	25	23	11	20	25	27	0	0.0638	1.000	1.000
532	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(17), EGF(15), EGFR(24), HGS(6), RAB5A(4), TF(19), TFRC(4)	11038842	89	67	87	37	22	18	8	24	16	1	0.773	1.000	1.000
533	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(11), G6PD(6), GCLC(4), GCLM(4), GGT1(9), GPX5(2), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTM2(1), GSTM3(3), GSTM4(3), GSTM5(3), GSTO2(4), GSTP1(2), GSTZ1(2), IDH1(5), IDH2(8), MGST1(3), MGST2(3), MGST3(5), PGD(9)	15562251	98	67	94	31	25	20	9	23	21	0	0.392	1.000	1.000
534	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(10), HK1(18), HK2(15), HK3(13), IMPA1(8), PGM1(4), PGM3(13), TGDS(7)	8855295	88	67	85	26	27	17	13	22	9	0	0.114	1.000	1.000
535	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(10), MAPK14(3), MAPK8(7), NFKB1(10), RELA(7), TNFRSF13B(7), TNFRSF13C(4), TNFRSF17(1), TNFSF13(6), TNFSF13B(5), TRAF2(5), TRAF3(8), TRAF5(7), TRAF6(7)	12568537	87	67	85	19	15	18	6	22	25	1	0.111	1.000	1.000
536	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(18), CHAT(14), CHKA(2), PCYT1A(11), PDHA1(1), PDHA2(16), PEMT(1), SLC18A3(17)	5967727	80	66	79	42	31	8	8	25	8	0	0.932	1.000	1.000
537	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(22), JAK2(14), JAK3(18), MAPK1(4), MAPK3(3), STAT3(9), TYK2(15)	10170467	85	65	81	30	16	12	13	20	21	3	0.811	1.000	1.000
538	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(3), CD4(11), FYN(10), HLA-DRA(7), HLA-DRB1(2), LCK(5), PTPRC(30), ZAP70(16)	7819509	84	64	77	36	22	9	11	28	14	0	0.905	1.000	1.000
539	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(4), CAMK1G(10), HDAC9(23), MEF2A(3), MEF2B(6), MEF2C(7), MEF2D(11), MYOD1(8), YWHAH(3)	6863568	75	63	73	30	18	7	9	18	23	0	0.737	1.000	1.000
540	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(11), POLR2A(27), POLR2B(16), POLR2C(5), POLR2E(3), POLR2F(4), POLR2G(1), POLR2H(1), POLR2I(2), POLRMT(17)	11604728	87	63	84	31	28	12	16	15	16	0	0.443	1.000	1.000
541	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(7), AKR1D1(4), CYP11A1(8), CYP11B1(19), CYP11B2(12), CYP17A1(8), CYP21A2(7), HSD11B1(5), HSD11B2(5), HSD3B1(6), HSD3B2(5)	8171657	86	62	84	31	28	13	7	27	11	0	0.595	1.000	1.000
542	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(3), CALM3(2), CAMK1(4), CAMK1G(10), CAMK2A(6), CAMK2B(9), CAMK2D(2), CAMK2G(10), CAMK4(10), CAMKK1(5), CAMKK2(6), CREB1(4), SYT1(8)	9973508	81	62	79	25	22	9	15	16	19	0	0.274	1.000	1.000
543	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(7), AKR1D1(4), CYP11A1(8), CYP11B1(19), CYP11B2(12), CYP17A1(8), CYP21A2(7), HSD11B1(5), HSD11B2(5), HSD3B1(6), HSD3B2(5)	8171657	86	62	84	31	28	13	7	27	11	0	0.595	1.000	1.000
544	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(7), CAT(6), GH1(3), GHR(11), HRAS(2), IGF1(3), IGF1R(24), PIK3R1(17), SHC1(7), SOD2(2)	9417000	82	62	81	36	16	13	17	15	20	1	0.889	1.000	1.000
545	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(8), ICAM1(5), ITGAL(28), ITGAM(13), ITGB2(12), SELE(9), SELL(7)	9029442	82	62	79	36	27	6	8	21	20	0	0.782	1.000	1.000
546	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(7), CBS(9), CTH(3), GGT1(9), MARS(10), MARS2(6), MAT1A(8), MAT2B(5), PAPSS1(6), PAPSS2(9), SCLY(6), SEPHS1(7)	10690313	85	62	82	30	25	11	15	14	20	0	0.404	1.000	1.000
547	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA3(6), PSMA4(4), PSMA5(1), PSMA6(9), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(2), PSMB6(5), PSMB7(1), PSMC3(10), PSMD14(2), RPN1(7), RPN2(9), UBE2A(1), UBE3A(8)	11226728	85	61	84	22	18	8	20	22	17	0	0.152	1.000	1.000
548	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(4), IL13RA1(6), IL13RA2(10), IL4R(10), JAK1(22), JAK2(14), TYK2(15)	9045319	81	61	78	24	16	12	13	16	21	3	0.506	1.000	1.000
549	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(4), IL13RA1(6), IL13RA2(10), IL4R(10), JAK1(22), JAK2(14), TYK2(15)	9045319	81	61	78	24	16	12	13	16	21	3	0.506	1.000	1.000
550	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(5), AGTR1(1), AGTR2(6), BDKRB2(3), KNG1(13), NOS3(20), REN(9)	8458258	71	60	67	24	16	9	9	13	24	0	0.545	1.000	1.000
551	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(7), BAD(4), CASP9(4), CHUK(10), GH1(3), GHR(11), NFKB1(10), NFKBIA(1), PDPK1(1), PIK3R1(17), PPP2CA(5), RELA(7), YWHAH(3)	10249130	83	60	81	25	14	13	16	17	22	1	0.406	1.000	1.000
552	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(9), ACO2(12), AFMID(5), CS(1), GRHPR(4), HAO1(6), HAO2(9), HYI(2), MDH1(5), MDH2(2), MTHFD1(9), MTHFD1L(12), MTHFD2(3)	11526494	79	60	78	24	21	18	9	17	14	0	0.212	1.000	1.000
553	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL1(3), FOSL2(11), IFNAR1(9), IFNAR2(4), IFNB1(4), MAPK8(7), NFKB1(10), RELA(7), TNFRSF11A(5), TNFSF11(5), TRAF6(7)	9530903	74	60	73	23	16	12	9	18	19	0	0.380	1.000	1.000
554	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	14	CYP51A1(13), DHCR7(10), FDFT1(5), FDPS(14), HMGCR(8), HMGCS1(2), IDI1(3), LSS(16), MVD(2), NSDHL(4), PMVK(1), SQLE(10)	10662789	88	59	85	25	22	8	7	25	26	0	0.398	1.000	1.000
555	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(12), CAPN1(8), CAPNS1(6), CAPNS2(3), CDK5(3), CDK5R1(6), CSNK1A1(7), CSNK1D(5), GSK3B(9), MAPT(12), PPP2CA(5)	8035816	76	59	74	24	20	17	9	16	14	0	0.212	1.000	1.000
556	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3E(3), GZMB(2), ICAM1(5), ITGAL(28), ITGB2(12), PRF1(17)	6629132	67	57	64	26	21	7	6	15	18	0	0.505	1.000	1.000
557	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(11), CARS2(9), CDO1(3), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHAL6A(4), LDHAL6B(7), LDHB(5), LDHC(1), MPST(3), SDS(5), SULT1B1(6), SULT1C2(4), SULT1C4(4), SULT4A1(1)	10856421	78	57	78	26	23	17	7	17	14	0	0.381	1.000	1.000
558	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX1(7), ACOX3(14), FADS2(6), PLA2G10(3), PLA2G12A(1), PLA2G12B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G2F(1), PLA2G3(11), PLA2G4A(8), PLA2G5(2), PLA2G6(11)	8608129	75	57	73	25	32	6	9	18	10	0	0.426	1.000	1.000
559	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(22), EIF2AK4(14), EIF2B5(11), EIF2S1(3), EIF2S2(3), EIF2S3(3), EIF5(6), GSK3B(9), PPP1CA(3)	9914591	74	56	73	17	15	5	14	23	16	1	0.139	1.000	1.000
560	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(8), CDKN1A(7), EPO(3), EPOR(5), GRIN1(11), HIF1A(10), JAK2(14), NFKB1(10), NFKBIA(1), RELA(7), SOD2(2)	10945448	78	56	76	23	16	21	7	12	21	1	0.237	1.000	1.000
561	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(9), ACO2(12), CS(1), GRHPR(4), HAO1(6), HAO2(9), HYI(2), MDH1(5), MDH2(2), MTHFD1(9), MTHFD1L(12), MTHFD2(3)	10994877	74	56	73	24	19	17	9	17	12	0	0.321	1.000	1.000
562	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(6), EGR1(14), HRAS(2), KLK2(2), MAP2K1(9), MAP2K2(6), MAPK1(4), MAPK3(3), NGFR(9), RAF1(11)	7112670	69	55	63	25	24	10	8	16	11	0	0.393	1.000	1.000
563	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(8), GSS(2), NFKB1(10), NOX1(8), RELA(7), TNF(3), XDH(32)	8571745	70	55	69	20	12	15	8	21	14	0	0.268	1.000	1.000
564	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(6), CHST11(4), CHST12(7), CHST13(6), PAPSS1(6), PAPSS2(9), SULT1A1(10), SULT1A2(8), SULT1E1(3), SULT2A1(4), SULT2B1(2), SUOX(8)	7959828	73	54	72	29	29	12	7	14	11	0	0.569	1.000	1.000
565	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(6), IARS(15), LARS(13), LARS2(12), PDHA1(1), PDHA2(16), PDHB(4)	8570534	67	54	66	26	9	9	12	23	14	0	0.831	1.000	1.000
566	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(10), FDFT1(5), FDPS(14), HMGCR(8), IDI1(3), LSS(16), MVD(2), NQO1(4), NQO2(4), PMVK(1), SQLE(10), VKORC1(2)	8826767	79	53	77	22	21	10	8	22	18	0	0.225	1.000	1.000
567	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(11), ENO1(4), GPI(6), HK1(18), PFKL(9), PGAM1(1), PGK1(5), PKLR(12), TPI1(3)	7996159	69	53	69	29	21	17	6	16	9	0	0.529	1.000	1.000
568	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(6), DHRS1(4), DHRS3(5), DHRS7(7), DHRSX(7), HSD3B7(9), PON1(4), PON2(5), PON3(9), RDH11(1), RDH12(3), RDH13(8)	7706181	68	53	66	24	20	9	8	20	11	0	0.570	1.000	1.000
569	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(8), ADSS(6), IMPDH1(7), MTHFD2(3), NME2(3), OAZ1(3), POLB(8), POLD1(18), POLG(10), PRPS2(5), RRM1(5), SRM(4)	10903143	80	52	79	25	25	17	7	14	17	0	0.319	1.000	1.000
570	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), PAK1(7), PDGFRA(17), PIK3R1(17), RAC1(2), WASL(7)	9680859	69	51	68	25	8	7	12	15	26	1	0.858	1.000	1.000
571	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(12), BMPR1A(13), BMPR1B(13), BMPR2(24)	5342297	62	51	60	16	8	4	11	12	25	2	0.508	1.000	1.000
572	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(12), CS(1), FH(4), IDH2(8), MDH1(5), OGDH(13), SDHA(15), SUCLA2(3)	8134665	61	50	57	19	20	11	4	8	18	0	0.348	1.000	1.000
573	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	HRAS(2), MMP14(11), MMP2(13), MMP9(23), RECK(10), TIMP1(1), TIMP2(1), TIMP4(3)	6227716	64	50	63	33	23	15	2	14	9	1	0.868	1.000	1.000
574	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(4), IFNG(3), IL10(4), IL12A(3), IL12B(3), IL13(4), IL15(2), IL16(21), IL18(1), IL1A(2), IL3(3), IL4(4), IL6(1), LTA(4), TNF(3)	8513653	63	49	63	23	13	9	8	20	13	0	0.573	1.000	1.000
575	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(5), APAF1(11), BCL2(4), CASP3(2), CASP9(4), DAXX(14), FAS(3), FASLG(6), HSPB1(2), HSPB2(2), IL1A(2), MAPKAPK2(4), MAPKAPK3(5), TNF(3)	9716105	67	49	66	28	20	8	6	17	16	0	0.752	1.000	1.000
576	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(9), FARSA(8), FARSB(4), GOT1(3), GOT2(2), PAH(10), TAT(7), YARS(9), YARS2(4)	7507130	56	48	56	21	15	8	6	16	11	0	0.709	1.000	1.000
577	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(9), HS3ST1(10), HS3ST2(12), HS3ST3A1(5), HS3ST3B1(5), XYLT1(14)	4285452	59	47	56	30	28	4	10	13	4	0	0.900	1.000	1.000
578	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(9), HS3ST1(10), HS3ST2(12), HS3ST3A1(5), HS3ST3B1(5), XYLT1(14)	4285452	59	47	56	30	28	4	10	13	4	0	0.900	1.000	1.000
579	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(7), ALPL(10), ALPP(16), ALPPL2(6), FPGS(8), GCH1(1), GGH(2), SPR(3)	5695103	53	46	52	31	26	6	1	10	10	0	0.853	1.000	1.000
580	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(11), CKM(2), EIF4E(2), FBL(8), GPT(8), LDHA(7), LDHB(5), LDHC(1), MAPK14(3), NCL(12)	7771460	59	46	58	22	14	13	2	16	14	0	0.770	1.000	1.000
581	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(9), TAX1BP3(1), UBE2A(1), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2D3(3), UBE2E1(4), UBE2E3(3), UBE2G2(3), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(5), UBE2L3(1), UBE2L6(2), UBE2M(2), UBE2N(3), UBE2S(3), UBE3A(8)	9104453	58	46	58	18	19	10	4	14	11	0	0.235	1.000	1.000
582	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(4), GRB2(4), HRAS(2), PTK2B(20), SHC1(7), SOS1(12), SRC(5)	7565577	54	45	53	15	16	6	4	17	11	0	0.368	1.000	1.000
583	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(7), ADORA2A(7), ADORA2B(4), ADORA3(9), LTB4R(2), P2RY1(5), P2RY2(5), P2RY6(12)	5013676	51	45	50	26	26	2	2	14	7	0	0.817	1.000	1.000
584	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(13), CCNA2(2), CCND1(3), CCNE1(7), CCNE2(3), CDK2(5), CDK4(2), CDKN1B(1), E2F1(6), E2F4(2), PRB1(5)	6617959	49	45	49	18	7	10	8	13	11	0	0.593	1.000	1.000
585	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(6), CYP11A1(8), CYP11B2(12), CYP17A1(8), HSD11B1(5), HSD11B2(5), HSD3B1(6), HSD3B2(5)	5952663	55	44	54	25	15	4	6	20	10	0	0.927	1.000	1.000
586	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(3), B3GALT2(10), B3GALT5(2), B3GNT5(12), FUT1(6), FUT2(2), FUT3(6), ST3GAL3(3), ST3GAL4(8)	6180637	52	44	49	19	20	5	2	12	13	0	0.770	1.000	1.000
587	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(10), NFKBIA(1), PLCB1(24), PRKCA(9), RELA(7)	7090946	55	44	53	16	13	9	4	14	15	0	0.337	1.000	1.000
588	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(9), ACAT2(6), BDH1(8), BDH2(4), HMGCS1(2), HMGCS2(6), OXCT1(10), OXCT2(7)	6191880	52	43	49	17	12	10	4	11	15	0	0.621	1.000	1.000
589	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(6), ENO3(4), FARS2(9), GOT1(3), GOT2(2), PAH(10), TAT(7), YARS(9)	7128611	54	42	54	20	15	11	6	13	9	0	0.479	1.000	1.000
590	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(11), CLOCK(8), CRY1(4), CRY2(9), CSNK1E(10), PER1(11)	7273230	53	41	51	19	19	9	4	6	15	0	0.713	1.000	1.000
591	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(9), AASDH(15), AASDHPPT(1), AASS(13), KARS(9)	5976290	47	41	46	15	8	12	8	9	10	0	0.500	1.000	1.000
592	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(8), CDKN1A(7), CHEK1(7), NEK1(9), WEE1(7)	6147789	46	40	46	13	9	9	4	12	12	0	0.531	1.000	1.000
593	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(14), GOT1(3), GOT2(2), TAT(7), TYR(18)	4029877	44	39	37	15	9	5	4	14	11	1	0.789	1.000	1.000
594	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA3(6), PSMA4(4), PSMA5(1), PSMA6(9), PSMA7(4), PSMB1(2), PSMB10(2), PSMB2(2), PSMB3(4), PSMB4(3), PSMB5(2), PSMB6(5), PSMB7(1), PSMB8(5), PSMB9(2)	7526974	57	39	57	20	16	6	11	13	11	0	0.568	1.000	1.000
595	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(5), GPD2(10), NDUFA1(2), SDHA(15), SDHB(4), SDHC(2), SDHD(3), UQCRC1(3)	5652740	44	38	44	16	11	5	7	11	10	0	0.511	1.000	1.000
596	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(8), FUT1(6), FUT2(2), FUT9(11), GCNT2(1), ST8SIA1(12)	5272905	40	37	38	16	14	3	3	16	4	0	0.638	1.000	1.000
597	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(13), CS(1), MDH1(5), ME1(2), PC(19), PDHA1(1), SLC25A1(4), SLC25A11(2)	7989494	47	37	46	21	17	6	7	11	6	0	0.811	1.000	1.000
598	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(3), NFYC(4), RB1(22), SP1(6), SP3(7)	5711323	43	37	42	11	6	5	6	9	17	0	0.445	1.000	1.000
599	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(3), DAG1(14), GNAQ(4), ITPKA(2), ITPKB(20)	5094914	47	36	46	19	16	2	7	11	11	0	0.776	1.000	1.000
600	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(6), PAPSS1(6), PAPSS2(9), SULT1A2(8), SULT1E1(3), SULT2A1(4), SUOX(8)	5215240	44	36	44	12	12	10	5	10	7	0	0.278	1.000	1.000
601	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(11), CD8A(4), CSF1(6), CSF3(3), EPO(3), IL11(3), IL3(3), IL4(4), IL6(1), IL7(2)	5280223	40	35	34	16	11	4	4	7	14	0	0.870	1.000	1.000
602	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(4), NDUFA4(1), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(8), NDUFS2(8), NDUFV1(6), NDUFV2(2)	6029551	44	34	43	11	9	8	6	10	11	0	0.341	1.000	1.000
603	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(5), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), RAC1(2), WASF1(11), WASL(7)	7034842	44	33	43	24	10	5	4	11	14	0	0.989	1.000	1.000
604	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(6), CYP2E1(8), NR1I3(3), PTGS1(15), PTGS2(7)	4603634	39	30	39	13	14	4	4	9	7	1	0.450	1.000	1.000
605	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(6), PLCD1(7), PRKCA(9), TGM2(12)	4290963	34	29	33	14	17	4	0	8	5	0	0.585	1.000	1.000
606	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(11), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHB(5), LDHC(1), MPST(3)	5886360	35	28	35	15	12	9	5	4	5	0	0.726	1.000	1.000
607	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(6), EPHX2(5), HSD3B7(9), RDH11(1), RDH12(3), RDH13(8)	4145738	32	28	31	14	10	6	3	7	6	0	0.743	1.000	1.000
608	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(10), DNAJC3(4), EIF2S1(3), EIF2S2(3), NFKB1(10), NFKBIA(1), RELA(7)	7799810	38	28	37	11	6	5	4	12	11	0	0.602	1.000	1.000
609	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(6), FUT2(2), FUT3(6), FUT5(4), FUT6(8), ST3GAL3(3)	4388646	29	26	29	17	14	4	2	6	3	0	0.908	1.000	1.000
610	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(7), COQ5(3), COQ6(4), COQ7(4), NDUFA12(2), NDUFA13(3), NDUFB11(2)	3517511	25	23	25	10	7	2	4	5	7	0	0.800	1.000	1.000
611	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(11), HLA-DRA(7), HLA-DRB1(2)	2034391	22	22	17	10	5	2	2	4	9	0	0.956	1.000	1.000
612	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(10), ALDH1A2(9), RDH5(3)	3335957	22	22	22	10	6	2	1	7	6	0	0.876	1.000	1.000
613	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(5), CD28(2), CD3E(3), CD4(11)	2753965	21	21	16	10	3	1	4	5	8	0	0.968	1.000	1.000
614	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(5), RAB11A(3), RAB1A(1), RAB27A(6), RAB3A(1), RAB4A(2), RAB5A(4)	3654573	22	18	20	19	8	2	4	4	4	0	0.990	1.000	1.000
615	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(7), PGLYRP2(8)	1536652	15	14	15	7	8	2	3	2	0	0	0.726	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		438523	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
