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MAF used for this analysis:LUAD.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 19
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 19. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| TP53 | 18396 | 0 | 2 | 73 | 28 | 2.3e-144 | 4.4e-140 |
| KRAS | 15183 | 0 | 0 | 38 | 0 | 7.9e-51 | 7.5e-47 |
| STK11 | 12403 | 1 | 0 | 18 | 9 | 2.5e-33 | 1.6e-29 |
| RBM10 | 29354 | 3 | 0 | 13 | 10 | 9.3e-26 | 4.4e-22 |
| FAM75C1 | 48575 | 0 | 2 | 15 | 0 | 9.7e-19 | 3.7e-15 |
| KRTAP4-11 | 6670 | 1 | 0 | 5 | 0 | 1.3e-11 | 3.9e-08 |
| LOC440563 | 15080 | 1 | 1 | 6 | 1 | 4.1e-10 | 1.1e-06 |
| DCAF8L2 | 15370 | 0 | 0 | 6 | 0 | 6.2e-10 | 1.5e-06 |
| AGAP6 | 33785 | 1 | 2 | 6 | 0 | 7.9e-08 | 0.00016 |
| KEAP1 | 27299 | 2 | 0 | 27 | 3 | 8.6e-08 | 0.00016 |
| SETD2 | 109343 | 1 | 0 | 18 | 12 | 1.4e-07 | 0.00024 |
| ZNF679 | 21170 | 2 | 1 | 6 | 2 | 2.1e-07 | 0.00032 |
| FSCB | 33435 | 0 | 2 | 15 | 2 | 1.1e-06 | 0.0015 |
| BRAF | 38106 | 2 | 1 | 15 | 2 | 1.1e-06 | 0.0015 |
| ZNF770 | 39560 | 0 | 2 | 6 | 0 | 1.3e-06 | 0.0016 |
| U2AF1 | 12849 | 1 | 0 | 5 | 0 | 1.6e-06 | 0.0019 |
| SMARCA4 | 69189 | 3 | 1 | 14 | 8 | 4.6e-06 | 0.0051 |
| HRNR | 79852 | 1 | 7 | 36 | 10 | 0.000014 | 0.014 |
| EGFR | 66577 | 12 | 5 | 24 | 6 | 0.000016 | 0.016 |
| ARID1A | 84972 | 3 | 1 | 10 | 8 | 0.00012 | 0.12 |
| CDKN2A | 5570 | 2 | 1 | 8 | 3 | 0.00016 | 0.15 |
| MGA | 142509 | 4 | 2 | 18 | 9 | 0.00017 | 0.15 |
| FAM75A2 | 19422 | 0 | 0 | 5 | 1 | 0.00018 | 0.15 |
| RGPD4 | 64670 | 6 | 3 | 14 | 0 | 0.00022 | 0.17 |
| FLG | 159865 | 2 | 17 | 102 | 15 | 0.00025 | 0.19 |
| POLR3B | 63072 | 4 | 0 | 12 | 2 | 0.00033 | 0.24 |
| NPSR1 | 23360 | 7 | 0 | 7 | 0 | 0.00035 | 0.24 |
| ANKRD55 | 30660 | 4 | 2 | 10 | 1 | 0.00042 | 0.28 |
| PKHD1L1 | 205279 | 22 | 12 | 40 | 4 | 0.0006 | 0.39 |
| MUC17 | 198266 | 7 | 17 | 56 | 4 | 0.00097 | 0.61 |
| FAM123C | 27735 | 0 | 1 | 13 | 3 | 0.001 | 0.63 |
| NEO1 | 71685 | 6 | 1 | 11 | 0 | 0.0013 | 0.78 |
| RIT1 | 11534 | 2 | 1 | 8 | 1 | 0.0014 | 0.78 |
| MUC7 | 15037 | 0 | 0 | 13 | 2 | 0.0015 | 0.83 |
| DLGAP2 | 25410 | 4 | 2 | 13 | 0 | 0.0016 | 0.84 |