rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AKT1(12), AKT2(1), AKT3(3), APAF1(1), ATM(12), BAD(1), BID(4), CAPN1(3), CAPN2(2), CASP6(2), CASP8(3), CSF2RB(2), DFFB(2), FAS(1), FASLG(1), IKBKB(3), IL1A(1), IL1R1(1), IL1RAP(2), IL3RA(1), IRAK1(1), IRAK2(3), IRAK3(1), IRAK4(2), NFKB1(1), NFKB2(3), NFKBIA(1), NTRK1(3), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), RIPK1(3), TNFRSF10D(1), TNFRSF1A(1), TP53(187) 64465557 491 359 244 28 43 129 50 162 106 1 <1.00e-15 <1.00e-15 <8.44e-15 2 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), E2F1(2), MDM2(2), MYC(1), PIK3CA(194), PIK3R1(14), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), RB1(10), TP53(187) 14816568 422 334 185 11 35 97 37 151 102 0 <1.00e-15 <1.00e-15 <8.44e-15 3 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(12), AKT2(1), AKT3(3), CASP8(3), CD14(1), CD40(1), CD86(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IKBKB(3), IKBKE(1), IL12A(1), IL12B(1), IL6(2), IRAK1(1), IRAK4(2), IRF3(2), JUN(1), LBP(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(20), MAP2K7(1), MAP3K7(1), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), RELA(1), RIPK1(3), SPP1(2), STAT1(1), TBK1(1), TICAM1(2), TIRAP(2), TLR1(1), TLR2(1), TLR3(1), TLR4(8), TLR5(1), TLR7(5), TLR8(3), TLR9(1), TRAF3(1), TRAF6(2) 67859415 340 267 165 40 20 108 32 126 53 1 1.50e-13 <1.00e-15 <8.44e-15 4 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(12), ATF2(2), DLD(1), DUSP10(1), DUSP4(1), GAB1(1), GCK(2), IL1R1(1), JUN(1), MAP2K4(20), MAP2K5(2), MAP2K7(1), MAP3K1(46), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP3K9(3), MAPK10(1), MAPK8(2), MYEF2(2), NFATC3(3), NR2C2(1), PAPPA(4), SHC1(1), TP53(187), TRAF6(2), ZAK(1) 38087868 317 263 230 21 42 46 38 51 125 15 4.52e-13 <1.00e-15 <8.44e-15 5 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(3), ELK1(2), FCER1A(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAP2K4(20), MAP2K7(1), MAP3K1(46), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PAK2(1), PIK3CA(194), PIK3R1(14), PLA2G4A(7), PLCG1(5), PPP3CA(3), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(2) 32114394 330 248 164 20 14 89 32 120 60 15 <1.00e-15 <1.00e-15 <8.44e-15 6 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(12), AKT2(1), AKT3(3), ARHGEF11(2), BTK(3), GDI1(4), INPPL1(2), ITPR1(8), ITPR2(3), ITPR3(4), LIMK1(3), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDK1(1), PIK3CA(194), PIK3CG(2), PIK3R1(14), PITX2(2), PPP1R13B(2), PTEN(17), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), SAG(1), WASF1(3), WASL(1) 53971164 302 248 128 33 14 97 30 121 39 1 7.40e-13 <1.00e-15 <8.44e-15 7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(12), AKT2(1), AKT3(3), BAD(1), CDK2(1), CDKN1B(5), CREB1(1), CREB3(1), EBP(1), ERBB4(6), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), IGF1(1), INPPL1(2), IRS1(1), IRS4(4), MET(5), MYC(1), NOLC1(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PARD3(3), PDK1(1), PIK3CA(194), PPP1R13B(2), PREX1(8), PTEN(17), PTK2(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(2), TSC1(3), TSC2(2), YWHAB(1) 57138393 306 247 132 28 18 98 38 117 34 1 2.78e-15 <1.00e-15 <8.44e-15 8 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BAK1(1), BID(4), CASP2(3), CASP6(2), CASP8(3), FAS(1), FASLG(1), JUN(1), MAP2K4(20), MAP3K1(46), MAPK10(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), PARP1(1), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TP53(187), TRAF1(1) 27872325 285 245 209 14 39 34 33 47 117 15 4.00e-15 <1.00e-15 <8.44e-15 9 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(12), AKT2(1), AKT3(3), BLNK(1), BTK(3), CARD11(3), CD19(2), CD22(2), CD79A(1), CD79B(1), CR2(2), IFITM1(1), IKBKB(3), INPP5D(3), JUN(1), KRAS(4), LYN(4), MALT1(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG2(2), PPP3CA(3), PPP3CB(3), SYK(2), VAV1(2), VAV2(1), VAV3(1) 56823546 294 244 120 35 12 99 38 117 27 1 1.27e-11 <1.00e-15 <8.44e-15 10 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(12), AKT2(1), AKT3(3), CAP1(2), CBL(1), F2RL2(1), GRB2(1), GSK3A(1), INPPL1(2), IRS1(1), IRS4(4), MAPK1(1), MAPK3(1), PARD3(3), PDK1(1), PIK3CA(194), PIK3R1(14), PPYR1(1), PTEN(17), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SORBS1(4), SOS1(4), SOS2(2), YWHAB(1) 43099563 280 244 106 26 14 90 28 113 34 1 2.09e-13 <1.00e-15 <8.44e-15 11 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(12), AKT2(1), AKT3(3), BAD(1), BCR(1), BLNK(1), BTK(3), CD19(2), CD22(2), CR2(2), DAG1(1), GRB2(1), GSK3A(1), INPP5D(3), ITPR1(8), ITPR2(3), ITPR3(4), LYN(4), MAP4K1(3), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(1), NR0B2(2), PDK1(1), PIK3CA(194), PIK3R1(14), PLCG2(2), PPP1R13B(2), PPP3CA(3), PPP3CB(3), PTPRC(1), RAF1(1), SHC1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2) 55433352 294 242 121 29 15 105 32 117 25 0 2.89e-15 <1.00e-15 <8.44e-15 12 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(12), BCR(1), CRKL(1), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAP2K4(20), MAP3K1(46), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(194), PIK3R1(14), RAF1(1), SOS1(4), STAT1(1), STAT5A(3), STAT5B(4) 20923890 313 241 138 12 12 89 17 117 63 15 <1.00e-15 <1.00e-15 <8.44e-15 13 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3E(1), CD3G(1), ELK1(2), GRB2(1), JUN(1), LAT(1), MAP2K1(1), MAP2K4(20), MAP3K1(46), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIA(1), PIK3CA(194), PIK3R1(14), PLCG1(5), PPP3CA(3), PPP3CB(3), PTPN7(2), RAF1(1), RASA1(2), RELA(1), SHC1(1), SOS1(4), VAV1(2), ZAP70(1) 35946807 320 241 155 21 15 85 26 119 60 15 <1.00e-15 <1.00e-15 <8.44e-15 14 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(12), AKT2(1), AKT3(3), BAD(1), BCR(1), BLNK(1), BTK(3), CD19(2), DAG1(1), EPHB2(2), GRB2(1), ITPKA(1), ITPKB(8), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CA(194), PIK3R1(14), PLCG2(2), PPP1R13B(2), RAF1(1), SERPINA4(3), SHC1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2) 39742716 281 240 108 15 18 96 25 115 26 1 <1.00e-15 <1.00e-15 <8.44e-15 15 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(2), CD36(1), CITED2(1), CPT1B(2), CREBBP(2), EHHADH(2), EP300(3), FABP1(1), HSD17B4(4), JUN(1), LPL(1), MAPK1(1), MAPK3(1), MRPL11(1), MYC(1), NCOA1(1), NCOR1(17), NCOR2(3), NFKBIA(1), NR0B2(2), NRIP1(1), PIK3CA(194), PIK3R1(14), PPARA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTGS2(1), RB1(10), RELA(1), SP1(2), STAT5A(3), STAT5B(4) 47935836 282 236 118 21 11 81 25 115 49 1 2.11e-15 <1.00e-15 <8.44e-15 16 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(12), AKT2(1), AKT3(3), BCR(1), BTK(3), CD19(2), GAB1(1), ITPR1(8), ITPR2(3), ITPR3(4), LYN(4), NR0B2(2), PDK1(1), PIK3CA(194), PITX2(2), PLCG2(2), PPP1R13B(2), PREX1(8), PTEN(17), PTPRC(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SAG(1), SYK(2), TEC(1), VAV1(2) 41993796 282 235 109 18 18 93 29 115 26 1 <1.00e-15 <1.00e-15 <8.44e-15 17 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(12), AKT2(1), AKT3(3), BRAF(3), EIF4B(1), FIGF(2), HIF1A(1), IGF1(1), MAPK1(1), MAPK3(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(3), RPS6(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(4), TSC1(3), TSC2(2), ULK1(2), ULK2(1) 41043171 271 234 98 23 11 96 24 117 23 0 5.11e-15 <1.00e-15 <8.44e-15 18 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(2), GRB2(1), JAK1(2), JUN(1), MAP2K1(1), MAP2K4(20), MAP3K1(46), MAPK3(1), MAPK8(2), PDGFRA(3), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(1), STAT5A(3) 26694057 307 233 142 13 14 79 22 115 62 15 <1.00e-15 <1.00e-15 <8.44e-15 19 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(1), ATM(12), ATR(2), BAI1(7), BID(4), CASP8(3), CCNB1(2), CCNB3(6), CCND1(1), CCND3(3), CCNE1(1), CCNG2(2), CDK2(1), CDK6(1), CHEK2(2), DDB2(1), FAS(1), GTSE1(7), IGF1(1), IGFBP3(1), LRDD(1), MDM2(2), PERP(2), PTEN(17), RCHY1(1), RRM2(1), SERPINE1(2), SESN2(2), SIAH1(3), STEAP3(1), THBS1(4), TP53(187), TP53I3(1), TP73(1), TSC2(2) 49849761 286 232 211 15 45 34 39 60 106 2 4.00e-15 <1.00e-15 <8.44e-15 20 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 ACTA1(1), AGT(3), AKT1(12), CALR(1), CAMK1(2), CAMK1G(1), CREBBP(2), EDN1(2), F2(3), HAND2(2), IGF1(1), LIF(3), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(2), MYH2(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NPPA(1), PIK3CA(194), PIK3R1(14), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1) 38119302 270 232 97 24 7 90 33 119 21 0 4.46e-14 <1.00e-15 <8.44e-15 21 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(12), ASAH1(1), BRAF(3), CREB1(1), CREB3(1), CREBBP(2), CRKL(1), DAG1(1), EGR1(1), EGR2(1), EGR3(3), ELK1(2), GNAQ(1), JUN(1), MAP1B(1), MAP2K4(20), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), NTRK1(3), OPN1LW(1), PIK3C2G(2), PIK3CA(194), PIK3R1(14), PTPN11(1), RPS6KA3(2), SHC1(1), TERF2IP(2) 39579462 285 232 111 18 15 90 25 116 39 0 <1.00e-15 <1.00e-15 <8.44e-15 22 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(12), CCNB1(2), CCND1(1), CCND3(3), CCNE1(1), CCNG2(2), CDC25A(1), CDK2(1), CDK7(2), CDKN1B(5), CREB3(1), CREB3L1(2), CREB3L3(3), E2F1(2), E2F3(1), E2F4(2), E2F5(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), MNAT1(1), MYC(1), MYT1(2), NACA(3), ORC1L(1), ORC2L(1), ORC3L(1), POLE(5), POLE2(1), RB1(10), RBL1(1), RPA1(1), TFDP1(1), TFDP2(2), TNXB(5), TP53(187), WEE1(1) 55818672 276 230 201 20 43 38 42 50 102 1 2.21e-12 <1.00e-15 <8.44e-15 23 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(12), CREB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(46), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(194), PIK3R1(14), RB1(10), RELA(1), SP1(2) 15156765 287 230 113 12 6 86 14 116 50 15 <1.00e-15 <1.00e-15 <8.44e-15 24 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), CRKL(1), ELK1(2), GAB1(1), GRB2(1), HGF(3), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(1), MAPK8(2), MET(5), PAK1(2), PIK3CA(194), PIK3R1(14), PTEN(17), PTK2(3), PTK2B(3), PTPN11(1), PXN(1), RAF1(1), RASA1(2), SOS1(4), STAT3(1) 34979451 273 230 109 16 14 84 24 114 36 1 <1.00e-15 <1.00e-15 <8.44e-15 25 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(12), CDKN1B(5), GRB2(1), ILK(2), ITGB1(2), MAPK1(1), MAPK3(1), PDK2(1), PIK3CA(194), PIK3R1(14), PTEN(17), PTK2(3), SHC1(1), SOS1(4) 14667003 258 226 83 10 7 89 15 111 35 1 <1.00e-15 <1.00e-15 <8.44e-15 26 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(12), EIF4A2(5), EIF4G1(1), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(1), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(3), PDK2(1), PIK3CA(194), PIK3R1(14), PTEN(17) 21334560 256 225 82 14 7 89 17 109 33 1 <1.00e-15 <1.00e-15 <8.44e-15 27 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(12), AKT2(1), AKT3(3), BAD(1), BTK(3), GRB2(1), GSK3A(1), IARS(6), INPP5D(3), PDK1(1), PIK3CA(194), PPP1R13B(2), PTEN(17), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(4), SOS2(2), TEC(1), YWHAB(1) 27296880 259 225 86 13 13 89 22 111 23 1 <1.00e-15 <1.00e-15 <8.44e-15 28 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(12), EIF4A2(5), EIF4B(1), EIF4G1(1), EIF4G2(1), EIF4G3(2), PDK2(1), PIK3CA(194), PIK3R1(14), PPP2CA(1), PTEN(17), RPS6(2), TSC1(3), TSC2(2) 21380697 256 224 82 11 7 89 17 111 31 1 <1.00e-15 <1.00e-15 <8.44e-15 29 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(1), CHN1(2), LIMK1(3), MAP3K1(46), MYLK(6), NCF2(2), PAK1(2), PDGFRA(3), PIK3CA(194), PIK3R1(14), PLD1(1), TRIO(2), VAV1(2), WASF1(3) 26788359 281 224 117 23 7 80 21 117 41 15 6.75e-13 <1.00e-15 <8.44e-15 30 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(12), ATR(2), BRCA1(8), BRCA2(11), CHEK2(2), FANCA(7), FANCC(1), FANCD2(3), FANCE(1), FANCF(1), FANCG(1), MRE11A(1), RAD17(2), RAD50(2), RAD51(1), RAD9A(2), TP53(187) 33653646 244 220 170 10 36 32 34 48 94 0 3.15e-13 <1.00e-15 <8.44e-15 31 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(12), BAD(1), CBL(1), CRKL(1), E2F1(2), GRB2(1), IL2RB(1), IL2RG(1), IRS1(1), JAK1(2), JAK3(2), MAPK1(1), MAPK3(1), MYC(1), PIK3CA(194), PIK3R1(14), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4), SYK(2) 27280149 251 220 78 19 10 88 15 114 24 0 1.11e-15 <1.00e-15 <8.44e-15 32 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(12), AKT2(1), AKT3(3), BAD(1), GRB2(1), GSK3A(1), IL4R(1), IRS1(1), JAK1(2), JAK3(2), MAP4K1(3), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(194), PIK3R1(14), PPP1R13B(2), RAF1(1), SHC1(1), SOS1(4), SOS2(2), STAT6(1) 26857818 250 220 77 15 9 90 17 111 23 0 <1.00e-15 <1.00e-15 <8.44e-15 33 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(12), CCND1(1), CCNE1(1), CDK2(1), CDK6(1), CDKN1B(5), E2F1(2), MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3CA(194), PIK3R1(14), RAF1(1), RB1(10), RELA(1), TFDP1(1) 15552225 250 219 76 8 8 86 13 111 32 0 <1.00e-15 <1.00e-15 <8.44e-15 34 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(3), AKT1(12), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREB1(1), GNAS(5), GRB2(1), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(194), PIK3R1(14), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), RPS6KA5(1), SOS1(4) 21999744 247 218 74 18 10 90 14 113 20 0 9.33e-15 <1.00e-15 <8.44e-15 35 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(12), APC(3), AXIN1(1), CCND1(1), CD14(1), DVL1(2), FZD1(1), GJA1(2), GNAI1(1), IRAK1(1), LBP(1), NFKB1(1), PIK3CA(194), PIK3R1(14), PPP2CA(1), RELA(1), TIRAP(2), TLR4(8) 22933638 247 218 73 19 8 88 13 117 21 0 4.44e-15 <1.00e-15 <8.44e-15 36 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP4A(2), INPP4B(4), INPPL1(2), ITPKA(1), ITPKB(8), OCRL(4), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(5), PLCG2(2) 34320858 251 217 89 17 14 80 25 114 18 0 <1.00e-15 <1.00e-15 <8.44e-15 37 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(12), AKT2(1), AKT3(3), GRB2(1), IARS(6), IL13RA1(1), IL2RG(1), IL4R(1), INPP5D(3), JAK1(2), JAK2(5), JAK3(2), NR0B2(2), PI3(1), PIK3CA(194), PPP1R13B(2), SERPINA4(3), SHC1(1), SOS1(4), SOS2(2), STAT6(1), TYK2(4) 28088814 252 217 79 15 13 87 21 114 17 0 <1.00e-15 <1.00e-15 <8.44e-15 38 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(12), APAF1(1), ATM(12), BAD(1), BID(4), CASP6(2), EIF2S1(1), PTK2(3), PXN(1), STAT1(1), TLN1(9), TP53(187) 21194628 234 216 150 7 33 44 28 44 85 0 <1.00e-15 <1.00e-15 <8.44e-15 39 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(12), AKT2(1), AKT3(3), BPNT1(1), GRB2(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(194), PTEN(17), PTK2B(3), RBL2(1), SHC1(1), SOS1(4) 15395562 243 215 70 9 8 87 15 109 23 1 <1.00e-15 <1.00e-15 <8.44e-15 40 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(20), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PIK3CA(194), PIK3R1(14), TRAF3(1), TRAF6(2) 25717068 251 215 87 15 11 78 16 111 34 1 <1.00e-15 <1.00e-15 <8.44e-15 41 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(3), AKT1(12), BAD(1), CSF2RB(2), IGF1(1), IGF1R(2), IL3RA(1), KIT(5), KITLG(2), PIK3CA(194), PIK3R1(14), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 16610841 240 214 67 11 6 89 17 110 18 0 <1.00e-15 <1.00e-15 <8.44e-15 42 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(3), AKT1(12), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(5), ITGB3(2), MAPK1(1), MAPK3(1), PDGFRA(3), PIK3CA(194), PIK3R1(14), PLCB1(4), PTK2(3), SMPD2(2) 20801703 247 214 74 13 9 91 16 111 20 0 <1.00e-15 <1.00e-15 <8.44e-15 43 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(2), GRB2(1), INSR(2), IRS1(1), JAK2(5), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), RPS6KA1(1), SHC1(1), SLC2A4(1), SOS1(4), SRF(1), STAT5A(3), STAT5B(4) 25079769 243 214 80 15 10 79 17 110 27 0 <1.00e-15 <1.00e-15 <8.44e-15 44 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(12), CREB1(1), GRB2(1), MAPK1(1), MAPK3(1), MEF2A(1), MEF2C(2), NTRK1(3), PIK3CA(194), PIK3R1(14), PLCG1(5), RPS6KA1(1), SHC1(1) 15181101 237 213 64 10 9 85 15 107 21 0 <1.00e-15 <1.00e-15 <8.44e-15 45 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), STAT1(1), STAT3(1), STAT5A(3), STAT5B(4) 22823112 240 213 77 10 10 76 16 109 29 0 <1.00e-15 <1.00e-15 <8.44e-15 46 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(12), BAD(1), GRB2(1), IGF1R(2), IRS1(1), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(194), PIK3R1(14), RAF1(1), SHC1(1), SOS1(4) 14305512 234 212 61 11 5 89 12 109 19 0 <1.00e-15 <1.00e-15 <8.44e-15 47 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), ELAVL1(2), FLT1(2), FLT4(1), HIF1A(1), KDR(2), NOS3(2), PIK3CA(194), PIK3R1(14), PLCG1(5), PTK2(3), PXN(1), SHC1(1) 26510523 237 212 74 16 9 79 19 110 20 0 4.00e-15 <1.00e-15 <8.44e-15 48 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(4), ATM(12), ATR(2), CCND1(1), CCNE1(1), CDC25A(1), CDK2(1), CDK6(1), CDKN1B(5), E2F1(2), HDAC1(2), RB1(10), TFDP1(1), TGFB3(1), TP53(187) 22504716 231 209 156 9 34 27 29 46 95 0 6.36e-14 <1.00e-15 <8.44e-15 49 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(3), AKT1(12), ATM(12), CPB2(1), FHL2(1), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(2), NQO1(1), TP53(187) 15096432 223 208 139 14 33 39 30 42 79 0 8.63e-11 <1.00e-15 <8.44e-15 50 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(12), BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PIK3CA(194), PIK3R1(14), PTK2(3), PTK2B(3) 12912276 233 207 59 9 5 88 14 109 17 0 <1.00e-15 <1.00e-15 <8.44e-15 51 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(12), CAT(1), GHR(2), IGF1(1), IGF1R(2), PIK3CA(194), PIK3R1(14), SHC1(1), SOD1(1) 9963564 228 207 55 7 4 85 15 107 17 0 <1.00e-15 <1.00e-15 <8.44e-15 52 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(6), ITGB1(2), KLRC1(2), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(2), PIK3CA(194), PIK3R1(14), PTK2B(3), SYK(2), VAV1(2) 14429727 233 207 69 13 8 77 19 109 20 0 <1.00e-15 <1.00e-15 <8.44e-15 53 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(12), BAD(1), GHR(2), NFKB1(1), NFKBIA(1), PIK3CA(194), PIK3R1(14), PPP2CA(1), RELA(1) 10832055 227 206 54 6 4 87 11 107 18 0 <1.00e-15 <1.00e-15 <8.44e-15 54 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 GNAI1(1), GNAQ(1), GNB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3CA(194), PIK3R1(14), PLCG1(5), PTK2(3), PTK2B(3), PXN(1), RAF1(1), RELA(1) 21474999 231 206 68 9 5 80 16 110 20 0 <1.00e-15 <1.00e-15 <8.44e-15 55 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(12), BRCA1(8), CHEK2(2), JUN(1), MAPK8(2), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(2), RAD51(1), RELA(1), TP53(187), TP73(1) 22260849 226 204 152 7 34 29 29 46 88 0 1.24e-14 <1.00e-15 <8.44e-15 56 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(2), GRB2(1), IGF1(1), IGF1R(2), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PIK3CA(194), PIK3R1(14), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1) 18760521 231 204 68 10 7 77 17 108 22 0 <1.00e-15 <1.00e-15 <8.44e-15 57 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), ELK1(2), GRB2(1), JUN(1), KLK2(2), MAP2K1(1), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), SHC1(1), SOS1(4) 14332890 231 204 68 8 8 77 14 109 23 0 <1.00e-15 <1.00e-15 <8.44e-15 58 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(2), GRB2(1), INSR(2), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PIK3CA(194), PIK3R1(14), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1) 19372977 231 203 68 11 7 77 16 109 22 0 <1.00e-15 <1.00e-15 <8.44e-15 59 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(12), CCND1(1), CCNE1(1), CDK2(1), E2F1(2), MDM2(2), RB1(10), TP53(187) 13917657 217 203 143 6 34 27 25 44 87 0 4.66e-15 <1.00e-15 <8.44e-15 60 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(12), CDC25A(1), CDC25B(3), CDC25C(1), CDK2(1), MYT1(2), RB1(10), TP53(187), WEE1(1) 13623597 218 203 144 6 32 27 28 44 87 0 2.33e-14 <1.00e-15 <8.44e-15 61 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(12), AKT2(1), AKT3(3), ELK1(2), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CA(194), SHC1(1), SOS1(4) 12494508 224 202 52 9 8 84 13 107 12 0 <1.00e-15 <1.00e-15 <8.44e-15 62 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(2), EP300(3), IL2RG(1), IL7R(1), JAK1(2), JAK3(2), PIK3CA(194), PIK3R1(14), PTK2B(3), STAT5A(3), STAT5B(4) 21495279 229 201 65 11 7 74 15 109 24 0 1.33e-15 <1.00e-15 <8.44e-15 63 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD3E(1), CD3G(1), CD86(2), CTLA4(1), GRB2(1), HLA-DRB1(4), ICOS(1), IL2(1), ITK(4), PIK3CA(194), PIK3R1(14), PTPN11(1) 9251736 225 200 62 10 5 76 16 110 18 0 <1.00e-15 <1.00e-15 <8.44e-15 64 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(2), PAX3(2), RARA(1), RB1(10), SIRT1(1), SP100(4), TNFRSF1A(1), TP53(187) 13908024 208 197 134 7 31 26 26 42 83 0 1.55e-14 <1.00e-15 <8.44e-15 65 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1A(1), ARPC1B(1), ARPC2(2), PAK1(2), PDGFRA(3), PIK3CA(194), PIK3R1(14), WASL(1) 10289565 218 196 55 12 5 75 14 106 18 0 1.30e-14 <1.00e-15 <8.44e-15 66 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(2), IKBKB(3), JAK2(5), NFKB1(1), NFKBIA(1), RB1(10), RELA(1), TNFRSF1A(1), TP53(187), USH1C(1), WT1(1) 13418262 213 196 139 6 32 26 26 43 86 0 <1.00e-15 <1.00e-15 <8.44e-15 67 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(1), CDK2(1), CDKN1B(5), E2F1(2), MDM2(2), PRB1(1), TP53(187) 6197568 200 193 125 4 33 24 24 40 79 0 <1.00e-15 <1.00e-15 <8.44e-15 68 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MAX(2), MYC(1), SP1(2), SP3(3), TP53(187), WT1(1) 5154162 198 190 124 6 30 25 24 43 76 0 6.77e-15 <1.00e-15 <8.44e-15 69 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(2), EIF2S1(1), EIF2S2(1), NFKB1(1), NFKBIA(1), RELA(1), TP53(187) 7773831 194 186 120 3 31 25 25 39 74 0 <1.00e-15 <1.00e-15 <8.44e-15 70 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP6(2), CASP8(3), DFFB(2), JUN(1), LMNB1(1), MAP2K4(20), MAP3K1(46), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(1), PRKDC(8), PTPN13(4), RB1(10), SPTAN1(2) 32747130 106 92 104 9 6 13 11 12 49 15 0.0043 <1.00e-15 <8.44e-15 71 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(1), CASP8(3), MAP2K1(1), MAP2K4(20), MAP3K1(46), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(3), RAF1(1), RELA(1), RIPK1(3), TNFRSF1A(1) 15271347 85 75 82 7 6 8 6 10 40 15 0.0064 <1.00e-15 <8.44e-15 72 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(3), IKBKB(3), JUN(1), LTA(1), MAP2K3(1), MAP2K4(20), MAP3K1(46), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TANK(1), TNFRSF1A(1) 18122715 86 75 84 6 6 7 11 7 40 15 0.0031 <1.00e-15 <8.44e-15 73 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(56), MAP2K3(1), MAPK14(1), NFATC1(1), NFATC2(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 8406567 63 61 41 9 0 1 5 5 51 1 0.97 <1.00e-15 <8.44e-15 74 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), GSN(1), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(6), PIK3CA(194), PIK3R1(14), PTK2(3), PXN(1), RAF1(1), ROCK1(1), SHC1(1), TLN1(9) 29134248 243 216 80 16 7 80 20 114 22 0 2.55e-15 1.33e-15 1.11e-14 75 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(3), ARHGEF1(5), F2(3), F2R(2), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(1), PIK3CA(194), PIK3R1(14), PLCB1(4), PTK2B(3), ROCK1(1) 19500234 233 209 70 10 6 78 21 108 20 0 2.22e-15 1.44e-15 1.19e-14 76 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(12), AKT2(1), AKT3(3), BTK(3), FCER1A(2), GAB2(2), GRB2(1), INPP5D(3), KRAS(4), LAT(1), LCP2(1), LYN(4), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(20), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), PDK1(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCG1(5), PLCG2(2), PRKCE(1), RAF1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2), VAV2(1), VAV3(1) 55090620 320 257 143 30 20 103 38 120 39 0 <1.00e-15 1.55e-15 1.24e-14 77 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(12), BAD(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), PIK3CA(194), PIK3R1(14), RAF1(1), RELA(1), RHOA(2) 15063984 230 209 57 11 6 86 12 108 18 0 <1.00e-15 1.55e-15 1.24e-14 78 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(1), INPP4A(2), INPP4B(4), INPP5B(4), INPPL1(2), IPMK(1), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(8), MINPP1(1), OCRL(4), PI4KA(4), PI4KB(1), PIK3C3(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), PTEN(17), SYNJ2(1) 56986800 300 253 137 32 19 82 40 121 37 1 2.80e-12 1.67e-15 1.32e-14 79 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(12), BUB1(1), CCNA2(2), CCNB1(2), CCNB3(6), CCND3(3), CCNE1(1), CDAN1(1), CDC25A(1), CDC25B(3), CDC25C(1), CDC7(1), CDH1(33), CDK2(1), CHEK2(2), DTX4(1), E2F1(2), E2F3(1), E2F4(2), E2F5(1), EP300(3), ESPL1(7), HDAC1(2), HDAC2(3), HDAC3(2), HDAC4(1), HDAC5(2), HDAC6(3), HDAC8(3), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), ORC1L(1), ORC2L(1), ORC3L(1), PLK1(2), PRKDC(8), PTPRA(1), PTTG2(1), RB1(10), RBL1(1), SMAD4(1), TBC1D8(1), TFDP1(1), TP53(187), WEE1(1) 85526844 337 270 259 32 44 45 50 62 135 1 1.14e-10 1.78e-15 1.35e-14 80 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(2), EGFR(5), ELK1(2), GRB2(1), JAK1(2), JUN(1), MAP2K1(1), MAP2K4(20), MAP3K1(46), MAPK3(1), MAPK8(2), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(1), STAT5A(3) 28561845 311 236 146 15 14 79 23 118 62 15 <1.00e-15 1.78e-15 1.35e-14 81 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(12), GNAS(5), GNB1(1), NFKB1(1), NOS3(2), NPPA(1), PIK3CA(194), PIK3R1(14), RELA(1) 13617006 231 207 58 7 5 86 12 109 19 0 <1.00e-15 1.78e-15 1.35e-14 82 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(12), ATR(2), BRCA1(8), CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), CHEK2(2), EP300(3), MDM2(2), MYT1(2), PRKDC(8), RPS6KA1(1), TP53(187), WEE1(1) 33087327 235 209 160 12 37 31 34 47 86 0 6.80e-13 1.89e-15 1.42e-14 83 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(12), EGFR(5), IGF1R(2), MYC(1), POLR2A(2), PPP2CA(1), RB1(10), TEP1(9), TP53(187) 21449142 229 207 145 10 31 39 29 48 82 0 1.55e-15 2.00e-15 1.48e-14 84 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(12), APC(3), AR(4), ASAH1(1), BRAF(3), CCL13(1), DAG1(1), EGFR(5), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PIK3CA(194), PIK3R1(14), PITX2(2), PTX3(1), RAF1(1) 41237352 276 238 103 26 10 94 23 122 27 0 2.70e-14 2.11e-15 1.55e-14 85 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(2), BAK1(1), BFAR(1), BTK(3), CAD(7), CASP8(3), EGFR(5), EPHB2(2), IL1A(1), MAP2K4(20), MAP2K7(1), MAP3K1(46), MAP3K5(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MET(5), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NR0B2(2), PTPN13(4), RIPK1(3), ROCK1(1), TP53(187), TUFM(2) 55873428 318 255 242 22 42 41 43 53 123 16 3.02e-13 2.33e-15 1.69e-14 86 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(2), AKT1(12), AKT2(1), AKT3(3), ARAF(1), BAD(1), BRAF(3), BTC(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CBL(1), CBLB(9), CBLC(3), CDKN1B(5), CRKL(1), EGF(2), EGFR(5), ELK1(2), ERBB2(8), ERBB3(9), ERBB4(6), GAB1(1), GRB2(1), JUN(1), KRAS(4), MAP2K1(1), MAP2K2(1), MAP2K4(20), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MYC(1), NCK1(1), NCK2(1), NRG1(1), NRG3(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(5), PLCG2(2), PRKCG(2), PTK2(3), RAF1(1), RPS6KB2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), STAT5A(3), STAT5B(4), TGFA(1) 77961897 384 276 206 46 27 110 54 138 55 0 4.80e-13 2.44e-15 1.73e-14 87 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(12), DAG1(1), DGKA(3), ITGA9(2), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(7), PDE3B(1), PI3(1), PIK3C2G(2), PIK3CA(194), PIK3R1(14), RIPK3(1), RPS4X(1), SGCB(1) 38066574 270 231 97 27 9 100 19 117 25 0 5.96e-14 2.44e-15 1.73e-14 88 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(12), ATR(2), CDC25C(1), CHEK2(2), TP53(187) 12093471 204 195 130 6 32 26 25 43 78 0 7.65e-12 2.66e-15 1.87e-14 89 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(12), CABIN1(5), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1(1), IGF1R(2), INSR(2), MAPK14(1), MEF2A(1), MEF2C(2), NFATC1(1), NFATC2(1), PIK3CA(194), PIK3R1(14), PPP3CA(3), PPP3CB(3) 26131794 247 216 74 20 4 92 17 113 21 0 3.44e-15 2.78e-15 1.92e-14 90 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(12), GRB2(1), KLK2(2), NTRK1(3), PIK3CA(194), PIK3R1(14), PLCG1(5), SHC1(1), SOS1(4) 11900811 236 213 63 8 6 87 14 109 20 0 <1.00e-15 2.89e-15 1.98e-14 91 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(12), PIK3CA(194), PIK3R1(14), PLCB1(4), PLCG1(5), VAV1(2) 9887514 231 212 58 7 7 85 12 107 20 0 1.89e-15 4.33e-15 2.93e-14 92 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAD(1), BAK1(1), BCL2L11(2), BID(4), CASP1(1), CASP2(3), CASP6(2), CASP8(3), DFFB(2), FAS(1), FASLG(1), IKBKB(3), IRF1(1), IRF3(2), IRF6(2), JUN(1), LTA(1), MAP2K4(20), MAP3K1(46), MAPK10(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIE(1), PLEKHG5(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TNFRSF21(2), TP53(187), TP73(1), TRAF1(1), TRAF3(1) 42863301 307 258 231 17 42 42 38 51 119 15 1.89e-15 4.44e-15 2.94e-14 93 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(12), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), IGF1(1), IGF1R(2), INPPL1(2), PDK2(1), PIK3CA(194), PIK3R1(14), PPP2CA(1), PTEN(17), RPS6(2) 14995539 250 223 76 13 6 87 18 109 29 1 <1.00e-15 4.44e-15 2.94e-14 94 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 IKBKAP(3), IKBKB(3), MAP3K1(46), NFKB1(1), NFKBIA(1), RELA(1), TNFAIP3(1), TRAF3(1), TRAF6(2) 14219322 59 50 58 7 1 5 6 6 26 15 0.21 5.41e-13 3.55e-12 95 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(12), AKT2(1), AKT3(3), BAD(1), KDR(2), KRAS(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NOS3(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCG1(5), PLCG2(2), PPP3CA(3), PPP3CB(3), PRKCG(2), PTGS2(1), PTK2(3), PXN(1), RAF1(1), SH2D2A(2), SHC2(1), SPHK2(2) 55078959 299 246 123 41 13 102 36 122 26 0 2.42e-10 6.79e-13 4.40e-12 96 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), IKBKB(3), IL2(1), JUN(1), MAP3K1(46), MAP3K5(2), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1) 15187692 61 51 60 7 2 3 8 6 27 15 0.23 8.96e-13 5.75e-12 97 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(5), MAP2K1(1), MAP3K1(46), MAPK14(1), NCOR2(3), RARA(1), THRA(1), THRB(1) 13511043 61 52 60 9 1 3 8 8 26 15 0.43 1.26e-12 7.98e-12 98 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(1), BAG4(1), CASP2(3), CASP8(3), DFFB(2), JUN(1), LMNB1(1), MADD(8), MAP2K4(20), MAP3K1(46), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(1), PRKDC(8), RB1(10), RIPK1(3), SPTAN1(2), TNFRSF1A(1) 29899311 116 98 114 11 7 15 14 14 51 15 0.0035 9.56e-11 6.01e-10 99 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 IKBKAP(3), IKBKB(3), LTA(1), MAP3K1(46), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TANK(1), TNFAIP3(1), TRAF1(1), TRAF3(1) 17274504 63 54 62 8 1 6 9 5 27 15 0.16 1.81e-10 1.13e-09 100 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(4), ANAPC1(2), ANAPC4(1), ANAPC5(5), ANAPC7(2), ATM(12), ATR(2), BUB1(1), CCNA2(2), CCNB1(2), CCNB3(6), CCND1(1), CCND3(3), CCNE1(1), CDC23(1), CDC25A(1), CDC25B(3), CDC25C(1), CDC27(1), CDC7(1), CDK2(1), CDK6(1), CDK7(2), CDKN1B(5), CHEK2(2), CREBBP(2), CUL1(1), E2F1(2), E2F3(1), EP300(3), ESPL1(7), HDAC1(2), HDAC2(3), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), ORC1L(1), ORC2L(1), ORC3L(1), PLK1(2), PRKDC(8), PTTG2(1), RB1(10), RBL1(1), RBL2(1), SMAD2(3), SMAD3(2), SMAD4(1), SMC1A(4), SMC1B(2), TFDP1(1), TGFB3(1), TP53(187), WEE1(1), YWHAB(1) 104866866 326 247 250 31 49 42 56 65 113 1 2.26e-10 1.99e-08 1.23e-07 101 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), AKT1(12), AKT2(1), AKT3(3), ARHGEF6(1), ARHGEF7(2), BRAF(3), CAV1(1), CSE1L(2), EPHB2(2), GRB2(1), GRB7(3), GRLF1(5), ILK(2), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGB3BP(1), MAP2K4(20), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MYLK(6), MYLK2(1), P4HB(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PIK3CA(194), PIK3CB(4), PKLR(1), PLCG1(5), PLCG2(2), PTEN(17), PTK2(3), RAF1(1), RHO(2), ROCK1(1), ROCK2(2), SHC1(1), SOS1(4), SOS2(2), TERF2IP(2), TLN1(9), TLN2(5), WAS(2) 93436551 376 280 202 52 34 107 43 133 58 1 2.05e-11 1.01e-07 6.18e-07 102 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(1), ELK1(2), IKBKB(3), IRAK1(1), JUN(1), MAP2K3(1), MAP2K4(20), MAP3K1(46), MAP3K7(1), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), PPARA(1), RELA(1), TIRAP(2), TLR10(1), TLR2(1), TLR3(1), TLR4(8), TLR7(5), TLR9(1), TRAF6(2) 28110108 104 86 101 12 11 10 11 11 46 15 0.012 1.33e-07 8.04e-07 103 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CRKL(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(20), MAP3K1(46), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4) 21717852 94 82 92 13 8 9 12 9 41 15 0.065 1.59e-07 9.48e-07 104 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(12), AKT2(1), AKT3(3), ARHGEF11(2), LPA(7), MAP2K4(20), MAP3K1(46), MAP3K5(2), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(4), PI3(1), PIK3CB(4), PLD1(1), PLD3(2), PTK2(3), RDX(1), ROCK1(1), ROCK2(2), SERPINA4(3), SRF(1) 37415079 125 103 113 13 15 22 17 9 46 16 0.00052 2.90e-07 1.72e-06 105 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(12), AKT2(1), AKT3(3), CBL(1), CBLB(9), CBLC(3), CCND1(1), CCND3(3), CNTFR(1), CREBBP(2), CSF2RA(2), CSF2RB(2), CSF3R(2), EP300(3), EPOR(2), GH2(2), GHR(2), GRB2(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(2), IL12A(1), IL12B(1), IL12RB1(3), IL13RA1(1), IL13RA2(3), IL15(1), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), IL7R(1), IRF9(3), JAK1(2), JAK2(5), JAK3(2), LEPR(3), LIF(3), LIFR(3), MYC(1), OSMR(4), PIAS2(3), PIAS4(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PRLR(1), PTPN11(1), SOCS4(1), SOCS5(1), SOS1(4), SOS2(2), SPRED1(3), SPRED2(1), SPRY3(1), STAM(2), STAM2(1), STAT1(1), STAT2(2), STAT3(1), STAT4(5), STAT5A(3), STAT5B(4), STAT6(1), TPO(6), TSLP(1), TYK2(4) 110778486 400 285 225 51 31 119 58 138 53 1 6.49e-14 4.50e-07 2.64e-06 106 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(3), CDH1(33), CREBBP(2), EP300(3), MAP2K1(1), MAP3K7(1), MAPK3(1), SKIL(2), TGFB3(1), TGFBR1(2), TGFBR2(3) 19726863 52 49 48 9 2 9 4 4 33 0 0.34 4.19e-06 0.000024 107 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), ATF2(2), EGFR(5), ELK1(2), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K4(20), MAP3K1(46), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(1), MEF2C(2), PAK1(2), PTK2(3), PTK2B(3), RAF1(1), SHC1(1), SOS1(4) 26257023 104 87 102 15 9 10 17 12 41 15 0.059 7.59e-06 0.000044 108 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(12), AKT2(1), AKT3(3), CARD11(3), CBL(1), CBLB(9), CBLC(3), CD3E(1), CD3G(1), CD4(2), CD40LG(1), CD8A(1), CTLA4(1), GRAP2(1), GRB2(1), ICOS(1), IKBKB(3), IL2(1), ITK(4), JUN(1), KRAS(4), LAT(1), LCP2(1), MALT1(1), MAP3K8(2), NCK1(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKCQ(3), PTPRC(1), RHOA(2), SOS1(4), SOS2(2), TEC(1), VAV1(2), VAV2(1), VAV3(1), ZAP70(1) 76554972 332 260 158 46 17 108 49 128 29 1 2.41e-10 8.63e-06 0.000049 109 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDK2(1), CDKN1B(5), CUL1(1), E2F1(2), NEDD8(1), RB1(10), TFDP1(1) 6656403 22 21 21 1 3 0 2 3 14 0 0.10 0.000055 0.00031 110 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(1), BLNK(1), ELK1(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAP3K1(46), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(4), RPS6KA1(1), RPS6KA3(2), SHC1(1), SOS1(4), SYK(2), VAV1(2), VAV2(1), VAV3(1) 24506352 83 71 82 10 10 8 14 10 26 15 0.021 0.00010 0.00056 111 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(5), AKT1(12), BMPR2(2), BUB1(1), CDKL1(2), CDKL2(1), CDS1(2), CDS2(1), CLK1(1), CLK4(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), IMPA1(1), INPP4A(2), INPP4B(4), INPPL1(2), ITPKA(1), ITPKB(8), MAP3K10(4), MOS(2), NEK1(1), NEK3(2), OCRL(4), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIM2(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(5), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), TGFBR1(2) 87942192 332 263 158 46 29 96 48 128 31 0 8.10e-11 0.00074 0.0041 112 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYB(1), NFYC(1), RB1(10), SP1(2), SP3(3) 5101941 17 16 17 2 0 1 0 5 11 0 0.39 0.0012 0.0068 113 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(2), CREB1(1), ELK1(2), GRB2(1), MAP2K4(20), MAP3K1(46), MAP3K5(2), MAP3K7(1), MAP3K9(3), MAPK14(1), MAX(2), MEF2A(1), MEF2C(2), MYC(1), PLA2G4A(7), RIPK1(3), RPS6KA5(1), SHC1(1), STAT1(1), TGFB3(1), TGFBR1(2) 28236858 101 83 98 14 6 12 18 8 42 15 0.079 0.0016 0.0087 114 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS1(2), CDS2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), IMPA1(1), INPP4A(2), INPP4B(4), INPP5B(4), INPP5D(3), INPPL1(2), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), OCRL(4), PI4KA(4), PI4KB(1), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3C3(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), PRKCG(2), PTEN(17), SYNJ2(1) 97330818 364 290 199 57 28 97 52 132 54 1 1.87e-08 0.0018 0.0098 115 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDK2(1), CUL1(1), E2F1(2), FBXW7(2), RB1(10), TFDP1(1) 6552975 18 17 18 1 4 0 1 4 9 0 0.098 0.0027 0.015 116 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(3), IL1A(1), IL1R1(1), IRAK1(1), MAP3K1(46), MAP3K7(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TLR4(8), TNFAIP3(1), TNFRSF1A(1), TRAF6(2) 18057312 71 57 69 11 4 6 9 9 28 15 0.27 0.0066 0.035 117 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 CCL11(1), CCR3(1), HLA-DRB1(4) 1828749 6 6 6 1 0 1 1 2 2 0 0.43 0.013 0.066 118 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), LPO(5), MPO(2), PRDX1(1), PRDX5(1), TPO(6), TYR(4) 7428057 20 20 20 2 6 2 5 3 4 0 0.067 0.013 0.069 119 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), CREM(2), FHL5(1), FSHR(4), GNAS(5), XPO1(3) 6833346 18 18 18 2 4 4 3 5 2 0 0.13 0.013 0.069 120 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNE1(1), CDK2(1), CUL1(1), E2F1(2), RB1(10), TFDP1(1) 6725862 16 15 16 1 3 0 1 3 9 0 0.15 0.016 0.082 121 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(8) 4432701 12 12 12 0 2 1 3 4 2 0 0.040 0.017 0.085 122 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNB1(2), CCND1(1), CCND3(3), CCNE1(1), CDC25A(1), CDK2(1), CDK6(1), CDK7(2), CDKN1B(5), E2F1(2), RB1(10), RBL1(1), TFDP1(1) 11870391 31 29 30 4 3 1 5 6 15 1 0.29 0.017 0.086 123 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(4), B3GALT1(1), B3GALT2(1), B3GALT5(1), FUT2(2), FUT3(4), ST3GAL3(1), ST3GAL4(1) 5407662 15 15 14 2 4 5 2 2 2 0 0.050 0.021 0.11 124 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(4), FUT2(2), FUT3(4), FUT5(1), ST3GAL3(1) 3810105 12 12 11 2 4 3 1 2 2 0 0.096 0.034 0.17 125 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR2(1), EGR3(3), GNAQ(1), MAP3K1(46), MYC(1), NFATC1(1), NFATC2(1), NFKB1(1), NFKBIA(1), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), VIP(1) 20556822 72 63 71 14 3 5 8 11 30 15 0.52 0.048 0.24 126 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IFNB1(1), IKBKB(3), IL1A(1), IL1R1(1), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(1), IRAK2(3), IRAK3(1), JUN(1), MAP2K3(1), MAP3K1(46), MAP3K7(1), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1), TGFB3(1), TRAF6(2) 22780524 76 62 75 12 6 8 9 9 29 15 0.22 0.049 0.24 127 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(4), ALDOB(2), TPI1(2) 2928939 8 8 8 0 0 4 3 0 1 0 0.051 0.057 0.28 128 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(1), APAF1(1), ARHGDIB(1), BAG4(1), BID(4), CASP2(3), CASP6(2), CASP8(3), DFFB(2), GSN(1), LMNB1(1), MAP2K7(1), MAP3K1(46), MAP3K5(2), MAPK8(2), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(3), PAK2(1), PRKDC(8), PSEN1(1), PSEN2(3), PTK2(3), RASA1(2), RB1(10), RELA(1), RIPK1(3), SPTAN1(2), TNFRSF1A(1), TRAF1(1) 53316627 114 95 113 12 10 16 15 15 43 15 0.0032 0.060 0.29 129 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(3), ASAH1(1), CERK(1), CREB1(1), CREB3(1), DAG1(1), EPHB2(2), GNAQ(1), ITPKA(1), ITPKB(8), JUN(1), MAP2K4(20), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4) 21423792 53 51 52 8 9 6 9 10 19 0 0.059 0.069 0.33 130 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA2(2), CCND1(1), CCNE1(1), CDK2(1), CDKN1B(5), E2F1(2), E2F4(2), PRB1(1) 6746142 15 15 14 2 4 1 0 2 8 0 0.32 0.071 0.33 131 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), LPO(5), MPO(2), TPO(6) 6402396 14 14 14 0 6 1 2 2 3 0 0.012 0.071 0.33 132 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(2), ALOX5(1), CBR1(1), CBR3(1), CYP4F2(1), EPX(1), GGT1(2), LPO(5), MPO(2), PLA2G2E(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(6) 21581976 43 41 41 3 9 5 14 7 8 0 0.00095 0.084 0.39 133 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(2), CBS(2), CTH(3), MUT(1) 3739125 8 8 8 0 1 1 1 1 4 0 0.14 0.087 0.40 134 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(3), CD79A(1), CD79B(1), ELK1(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAP3K1(46), MAPK14(1), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PLCG1(5), PPP3CA(3), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(2) 28636881 94 81 93 16 8 12 16 13 30 15 0.11 0.087 0.40 135 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), KHK(1), LCT(6), PGM1(2), PYGL(1), PYGM(4), TPI1(2), TREH(1) 10340265 18 18 18 1 3 1 3 5 6 0 0.043 0.13 0.58 136 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(1), GNB1(1), HTR2C(1), PLCB1(4), TUB(2) 5413746 11 11 11 1 3 1 5 1 1 0 0.20 0.13 0.60 137 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(1), CD3E(1), CD3G(1), CD4(2), CD8A(1), IL6(2), KITLG(2) 4752618 12 12 12 3 0 3 4 2 3 0 0.47 0.14 0.63 138 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(1), EPX(1), LPO(5), MPO(2), PRDX1(1), PRDX5(1), TPO(6) 9083412 17 17 17 1 7 1 2 3 4 0 0.036 0.14 0.63 139 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(1) 894855 2 2 2 0 0 1 0 1 0 0 0.51 0.15 0.68 140 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(4), PLCB2(2), VIP(1) 8374626 16 16 16 2 2 6 3 3 2 0 0.11 0.16 0.69 141 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1) 4319640 9 9 9 1 1 3 2 2 1 0 0.18 0.17 0.74 142 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12A(1), IL12B(1), IL2(1) 2357043 4 4 4 1 0 0 0 3 1 0 0.82 0.19 0.84 143 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(1), GAD1(2), GAD2(3), GGT1(2) 4423575 9 9 9 0 2 2 3 1 1 0 0.045 0.20 0.87 144 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 549588 1 1 1 1 0 0 0 0 1 0 0.92 0.24 1.00 145 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(3) 1313637 3 3 3 1 2 0 0 0 1 0 0.79 0.26 1.00 146 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(1), EPX(1), LPO(5), MPO(2), TPO(6) 8813181 15 15 15 1 7 1 2 2 3 0 0.049 0.26 1.00 147 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), CD38(2), ENPP1(4), ENPP3(2), NMNAT1(1), NMNAT2(1), NNT(4), NT5E(3) 11018631 20 20 20 3 0 1 13 4 2 0 0.33 0.27 1.00 148 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(2) 1214772 2 2 2 0 0 0 1 0 1 0 0.55 0.27 1.00 149 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), HSD17B1(1), HSD17B2(1), HSD17B4(4), HSD3B2(3) 6183372 10 10 10 1 2 1 5 1 1 0 0.29 0.28 1.00 150 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BID(4), BRAF(3), CD244(1), FAS(1), FASLG(1), GRB2(1), HLA-A(6), HLA-C(3), HLA-E(2), HLA-G(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), ITGAL(1), ITGB2(3), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL2(4), KLRC1(2), KLRC3(1), KLRK1(2), KRAS(4), LAT(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(1), NCR1(1), NCR2(2), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PAK1(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(5), PLCG2(2), PPP3CA(3), PPP3CB(3), PRF1(2), PRKCG(2), PTK2B(3), PTPN11(1), RAF1(1), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), SYK(2), TNFRSF10D(1), ULBP1(1), ULBP3(2), VAV1(2), VAV2(1), VAV3(1), ZAP70(1) 85272837 343 261 178 58 20 105 55 126 37 0 9.95e-08 0.31 1.00 151 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP11B2(3), CYP17A1(1), HSD11B1(2), HSD3B2(3) 5225142 11 11 11 2 1 0 7 3 0 0 0.40 0.31 1.00 152 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(3), CPS1(5), GLS(1) 5934435 11 11 11 2 1 2 4 3 1 0 0.36 0.33 1.00 153 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(1), PCYT1A(1), PDHA1(2), PDHA2(2), SLC18A3(2) 5192187 10 10 10 1 2 4 4 0 0 0 0.085 0.33 1.00 154 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB1A(1), RAB3A(1), RAB6A(1) 3309189 5 5 5 0 0 0 2 0 3 0 0.39 0.33 1.00 155 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 1678677 3 3 3 1 1 0 0 2 0 0 0.75 0.34 1.00 156 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD4(2), HLA-DRB1(4) 1323270 6 6 6 3 0 1 2 2 1 0 0.73 0.35 1.00 157 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(12), CDC25A(1), CDC25B(3), CDC25C(1), MYT1(2), WEE1(1) 10634325 20 19 20 3 3 4 5 3 5 0 0.16 0.39 1.00 158 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(4), FBL(2), LDHC(1), MAPK14(1), NCL(2) 6997107 10 10 10 1 3 3 2 1 1 0 0.14 0.41 1.00 159 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PNPO(2) 3656484 5 5 5 1 0 0 3 1 1 0 0.62 0.44 1.00 160 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(2), JAK2(5), STAT1(1) 6277167 8 8 8 1 0 0 2 2 4 0 0.65 0.44 1.00 161 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(1) 2421432 4 4 4 0 1 0 3 0 0 0 0.32 0.44 1.00 162 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(3), IL4R(1), JAK1(2), JAK2(5), TYK2(4) 8002995 16 15 15 3 1 1 6 5 3 0 0.43 0.45 1.00 163 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(3), IL4R(1), JAK1(2), JAK2(5), TYK2(4) 8002995 16 15 15 3 1 1 6 5 3 0 0.43 0.45 1.00 164 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD3E(1), CD3G(1), CD4(2) 2491905 5 5 5 2 0 2 1 1 1 0 0.71 0.46 1.00 165 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(1), IL22RA1(1), IL22RA2(1), JAK1(2), JAK2(5), JAK3(2), STAT1(1), STAT3(1), STAT5A(3), STAT5B(4), TYK2(4) 14153919 26 25 25 4 7 0 7 4 8 0 0.14 0.47 1.00 166 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 1160523 1 1 1 0 0 0 0 0 1 0 0.88 0.48 1.00 167 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1) 4275531 5 5 5 1 2 1 2 0 0 0 0.52 0.50 1.00 168 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 16 PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), PSMB8(1) 6059664 8 8 8 0 1 1 3 2 1 0 0.11 0.50 1.00 169 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), IDS(3), IDUA(2), LCT(6), NAGLU(1) 11059191 19 17 19 2 4 4 4 6 1 0 0.059 0.50 1.00 170 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), CFTR(6), GNAS(5), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(2) 9502194 19 19 19 4 3 2 4 6 4 0 0.48 0.51 1.00 171 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCL11(1), CCR3(1), CD4(2), HLA-DRB1(4), IL5RA(1), IL6(2) 3598179 11 11 11 4 1 2 2 2 4 0 0.62 0.52 1.00 172 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BAK1(1), BID(4), CASP6(2), CASP8(3), DFFB(2) 10306803 13 13 13 1 2 6 0 1 4 0 0.084 0.54 1.00 173 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(1), PTGS1(1), PTGS2(1) 4016454 4 4 4 0 2 0 1 0 1 0 0.31 0.54 1.00 174 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(5), PTK2B(3) 5095350 9 9 9 2 1 3 3 0 2 0 0.33 0.55 1.00 175 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(1), UBE2D2(2), UBE2E1(1), UBE2E3(1), UBE2J1(3), UBE2J2(1), UBE3A(1) 8021754 11 11 11 1 0 4 4 0 3 0 0.27 0.55 1.00 176 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(3), LRP8(1), RELN(13), VLDLR(3) 10644465 21 20 20 4 4 3 8 3 3 0 0.24 0.55 1.00 177 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(3) 2888379 3 3 3 0 0 1 0 1 1 0 0.42 0.56 1.00 178 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(3), COASY(3), DPYD(1), DPYS(1), ENPP1(4), ENPP3(2), PANK2(1), PANK4(3), UPB1(3) 10425441 21 20 21 4 2 3 5 6 5 0 0.32 0.56 1.00 179 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(3), COPA(2), GBF1(4), GPLD1(3), KDELR3(1) 12398178 16 16 16 1 2 2 8 2 2 0 0.053 0.57 1.00 180 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(2), UXS1(2) 3062280 5 4 5 0 1 2 1 1 0 0 0.19 0.58 1.00 181 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(3) 10289565 18 16 18 3 2 8 5 2 1 0 0.10 0.58 1.00 182 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), CDK7(2), MNAT1(1), XPO1(3) 6544356 13 13 13 3 2 2 7 1 1 0 0.56 0.58 1.00 183 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), GPI(2), HK1(1), PGK1(2), PKLR(1), TPI1(2) 7071129 11 11 11 3 1 3 2 2 3 0 0.39 0.58 1.00 184 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(3), ASPA(2), CAD(7), CRAT(3), DARS(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), PC(3) 20201922 39 35 39 4 5 10 16 3 5 0 0.0036 0.58 1.00 185 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(1), BCMO1(4), RDH5(2) 2952768 9 9 9 6 1 1 4 0 3 0 0.95 0.59 1.00 186 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(3), SNCAIP(3) 4820049 8 8 8 2 1 2 4 1 0 0 0.61 0.60 1.00 187 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(3) 9797268 18 16 18 3 2 8 5 2 1 0 0.11 0.60 1.00 188 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(1), FOSB(1), GRIA2(1) 2738307 3 3 3 1 0 1 1 1 0 0 0.69 0.61 1.00 189 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(2), HSD11B1(2), HSD3B2(3) 7330206 15 15 15 3 2 1 10 2 0 0 0.34 0.62 1.00 190 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(2), HSD11B1(2), HSD3B2(3) 7330206 15 15 15 3 2 1 10 2 0 0 0.34 0.62 1.00 191 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(1), NFKBIA(1), PLCB1(4), RELA(1) 6248268 8 8 8 1 2 2 2 0 2 0 0.30 0.63 1.00 192 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT2(1), TYR(4) 3565224 6 6 6 2 0 2 4 0 0 0 0.72 0.63 1.00 193 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2) 8089692 24 23 22 5 2 5 9 6 2 0 0.26 0.63 1.00 194 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), RPN1(2), UBE2A(1), UBE3A(1) 10095384 11 11 11 1 0 2 5 2 2 0 0.26 0.64 1.00 195 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(5), ERBB3(9), NRG1(1) 7743918 17 17 17 4 2 2 7 5 1 0 0.48 0.65 1.00 196 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAD(1), BAK1(1), BCL2L11(2), BID(4), CES1(2) 8892780 11 11 11 1 3 4 1 1 2 0 0.18 0.65 1.00 197 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4), SELP(5) 12628863 18 17 18 2 1 2 7 5 3 0 0.13 0.65 1.00 198 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL10RA(1), IL10RB(3), IL1A(1), IL6(2), JAK1(2), STAT1(1), STAT3(1), STAT5A(3) 9038289 14 13 14 2 5 1 2 1 5 0 0.15 0.66 1.00 199 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), CD38(2), ENPP1(4), ENPP3(2), NADK(1), NMNAT1(1), NMNAT2(1), NNT(4), NT5C1B(4), NT5C3(1), NT5E(3) 16372044 26 26 26 4 1 1 16 6 2 0 0.25 0.66 1.00 200 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD3G(1), CD8A(1), ITGAL(1), ITGB2(3), PTPRC(1) 8056230 10 10 10 1 0 2 3 3 2 0 0.20 0.66 1.00 201 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP8(3), JUN(1), PRF1(2) 9735414 12 12 12 2 2 2 1 3 4 0 0.33 0.66 1.00 202 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(1), CASP8(3), RIPK1(3), TNFRSF1A(1) 5615025 8 8 8 2 1 2 1 1 3 0 0.50 0.66 1.00 203 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1298427 1 1 1 1 1 0 0 0 0 0 0.93 0.67 1.00 204 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFB4(1), NDUFS2(2), NDUFV1(1), NDUFV2(1) 5507034 7 7 7 1 3 1 1 1 1 0 0.39 0.68 1.00 205 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(3), GOT2(1), LDHC(1) 5029947 5 5 5 0 0 1 1 0 3 0 0.27 0.68 1.00 206 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), MST1(3), MST1R(1) 4712565 6 5 6 0 2 1 2 0 1 0 0.19 0.68 1.00 207 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX5(1), DPEP1(3), GGT1(2), PLA2G6(2), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1) 12007281 15 15 14 1 4 1 6 1 3 0 0.045 0.68 1.00 208 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), XDH(3) 6165120 10 10 10 2 2 2 3 3 0 0 0.27 0.68 1.00 209 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(1), ITGAM(1), ITGB2(3), SELE(1), SELL(4) 8400483 10 10 10 1 0 0 4 3 3 0 0.25 0.69 1.00 210 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ6(2), NDUFA13(1) 3218436 4 4 4 0 0 1 2 1 0 0 0.36 0.70 1.00 211 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), HGSNAT(3), HPSE(4), HPSE2(1), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(6), NAGLU(1) 15862509 29 26 29 4 5 5 8 9 2 0 0.078 0.70 1.00 212 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(4), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME2(2), ME3(2), PGK1(2), PKLR(1), TKT(1), TPI1(2) 13671255 21 21 21 3 5 8 7 0 1 0 0.027 0.70 1.00 213 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA3(2), P2RY1(2), P2RY2(1), P2RY6(1) 4208607 7 7 7 2 2 2 1 2 0 0 0.39 0.71 1.00 214 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(2), CHAT(1), DBH(4), DDC(1), GAD1(2), GAD2(3), MAOA(2), PAH(1), SLC18A3(2) 10907598 18 18 18 3 4 4 6 2 2 0 0.17 0.71 1.00 215 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(2), IFNAR1(1), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2), TRAF6(2) 8162193 13 13 13 3 2 6 1 2 2 0 0.22 0.72 1.00 216 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(1), PPARG(1) 4101630 4 4 4 1 0 1 3 0 0 0 0.70 0.72 1.00 217 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(4), G6PD(1), GCLC(2), GCLM(1), GGT1(2), GPX5(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTO2(1), GSTT1(1), GSTZ1(1), IDH1(1), PGD(2) 14330862 22 22 22 3 6 3 4 6 3 0 0.073 0.72 1.00 218 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(2), ACPP(2), ACPT(2), ENPP1(4), ENPP3(2), TYR(4) 7538076 16 16 16 4 2 2 9 1 2 0 0.58 0.73 1.00 219 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(2), UXS1(2) 3856749 5 4 5 0 1 2 1 1 0 0 0.20 0.73 1.00 220 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(1), PC(3), PDHA1(2) 7122336 10 10 10 2 2 3 2 1 2 0 0.26 0.74 1.00 221 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(2), CD3E(1), CD3G(1), CD4(2), CXCR3(2), IL12A(1), IL12B(1), IL12RB1(3), JAK2(5), STAT4(5), TYK2(4) 11491155 28 24 27 7 1 5 5 9 8 0 0.41 0.74 1.00 222 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(1), NFKB1(1), NOX1(1), RELA(1), SOD1(1), XDH(3) 7397130 8 8 8 0 1 1 2 3 1 0 0.12 0.74 1.00 223 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS2(3), DHRS7(1), PON1(1), PON2(1), PON3(1), RDH11(2), RDH12(1), RDH14(1) 6806982 11 10 11 3 1 3 1 3 3 0 0.40 0.75 1.00 224 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(2), PGM3(1), TGDS(2) 7859514 11 11 11 2 3 1 1 5 1 0 0.27 0.77 1.00 225 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), LCMT1(1), LCMT2(5), METTL2B(2), PCYT1A(1), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), WBSCR22(2) 10546107 27 23 27 6 5 7 9 1 5 0 0.18 0.77 1.00 226 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(4), ALDOB(2), GCK(2), GMDS(2), HK1(1), HK3(2), KHK(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(4), PFKP(4), SORD(1), TPI1(2) 18792462 30 29 30 4 9 5 6 5 5 0 0.013 0.78 1.00 227 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(1), HGD(1) 1722279 3 3 3 2 1 0 0 2 0 0 0.89 0.78 1.00 228 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(3), IDH1(1), MDH2(2), SDHB(1), SUCLA2(1) 6888102 9 9 9 2 1 2 2 4 0 0 0.45 0.78 1.00 229 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4) 9516390 12 12 12 2 0 0 5 5 2 0 0.42 0.78 1.00 230 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CD8A(1), CSF1(2), IL2(1), IL6(2) 4738422 8 8 8 3 0 2 3 1 2 0 0.65 0.80 1.00 231 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), GOT2(1), HPD(1), LPO(5), MAOA(2), MAOB(1), MPO(2), PRDX1(1), PRDX5(1), TPO(6) 16810599 34 33 34 6 7 4 11 5 7 0 0.078 0.80 1.00 232 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO3(2), FARS2(1), GOT2(1), PAH(1) 6288828 6 6 6 0 0 1 4 1 0 0 0.21 0.82 1.00 233 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(3), F2(3), F2R(2), FGA(3), FGG(1), PLAT(2), PLAU(2), PLG(4), SERPINE1(2) 10355475 23 23 23 5 1 4 13 4 1 0 0.37 0.82 1.00 234 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(1), FARSB(3), GOT2(1), PAH(1) 6656910 7 7 7 1 1 1 5 0 0 0 0.37 0.82 1.00 235 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1) 1990989 1 1 1 0 0 0 1 0 0 0 0.81 0.83 1.00 236 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(1), IFNAR2(1), IFNB1(1), JAK1(2), STAT1(1), STAT2(2), TYK2(4) 8247369 13 13 12 3 2 4 2 4 1 0 0.30 0.83 1.00 237 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(12), BMPR1B(2), CDKN1B(5), DMC1(2), EGR1(1), ESR2(2), FSHR(4), GJA4(1), LHCGR(4), MLH1(1), MSH5(1), NCOR1(17), NRIP1(1), PGR(2), PRLR(1), ZP2(2) 25863591 58 53 57 10 3 11 7 8 28 1 0.10 0.84 1.00 238 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(3), CDK7(2), NEK1(1), WEE1(1) 5850780 8 8 8 2 1 2 4 1 0 0 0.63 0.84 1.00 239 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC1(1), APOBEC2(1), APOBEC3A(1), APOBEC3B(1), APOBEC3G(1), APOBEC4(1) 5596266 7 7 7 2 4 1 0 1 1 0 0.65 0.85 1.00 240 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(5), JAK3(2), MAPK1(1), MAPK3(1), STAT3(1), TYK2(4) 8997222 16 15 15 4 4 1 3 4 4 0 0.48 0.86 1.00 241 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(4), PPT2(1) 6248775 10 10 10 3 0 3 4 2 1 0 0.65 0.86 1.00 242 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1B(2), BMPR2(2) 4678089 5 5 4 3 0 2 0 0 3 0 0.77 0.87 1.00 243 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(1), CASP8(3), JUN(1), MAP2K4(20), MAP3K7(1), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NR2C2(1), RIPK1(3), TNFAIP3(1), TNFRSF1A(1) 19919523 38 36 37 9 5 7 6 2 17 1 0.44 0.87 1.00 244 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), IDI1(2), SQLE(1) 2524860 5 5 5 3 1 1 2 0 1 0 0.91 0.87 1.00 245 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(3), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(3), ASPA(2), ASS1(1), CAD(7), CRAT(3), DARS(1), DARS2(1), DLAT(1), DLD(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), NARS2(2), PC(3), PDHA1(2), PDHA2(2), PDHB(1) 29281785 53 47 53 6 9 14 21 4 5 0 0.0014 0.87 1.00 246 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(2), ACP6(1), ACPP(2), ACPT(2), ENPP1(4), ENPP3(2), MTMR2(1), MTMR6(1), TYR(4) 11605737 19 19 19 4 2 4 9 2 2 0 0.39 0.88 1.00 247 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), PSMD1(5), PSMD11(1), PSMD2(1), PSMD6(2) 12322635 16 16 16 3 2 3 5 3 3 0 0.38 0.89 1.00 248 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(3), F2R(2), F5(11), F7(1), FGA(3), FGG(1), PROC(1), PROS1(1), SERPINC1(3), TFPI(1) 12507183 27 26 27 6 3 6 10 5 3 0 0.30 0.89 1.00 249 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT3(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 5965869 7 7 7 2 0 3 1 1 2 0 0.61 0.90 1.00 250 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(2), PGM3(1), TGDS(2) 8939931 11 11 11 2 3 1 1 5 1 0 0.26 0.90 1.00 251 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(2), RANGAP1(2) 6500247 5 5 5 0 0 1 2 0 2 0 0.50 0.90 1.00 252 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(5), GNB1(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 7183176 10 10 10 3 2 2 2 3 1 0 0.66 0.90 1.00 253 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), FPGS(1), GCH1(1) 4874805 10 9 9 4 4 1 4 0 1 0 0.61 0.90 1.00 254 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(1), CD3G(1), CXCR3(2), ETV5(1), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), JAK2(5), JUN(1), MAPK14(1), MAPK8(2), STAT4(5), TYK2(4) 14431755 30 27 29 8 2 4 5 9 10 0 0.49 0.90 1.00 255 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD4(2), HLA-DRB1(4), IL2(1) 2540070 7 7 7 4 0 1 2 3 1 0 0.83 0.90 1.00 256 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(4), B3GNT1(1), FUT2(2), ST8SIA1(1) 4617756 8 8 7 4 1 2 1 2 2 0 0.66 0.91 1.00 257 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(2) 3333525 2 2 2 1 1 0 0 0 1 0 0.79 0.91 1.00 258 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(3), BDKRB2(1), KNG1(3), NOS3(2) 7725159 11 11 11 3 0 3 4 3 1 0 0.44 0.91 1.00 259 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP68(2), SRP72(1), SRPR(7) 5730114 10 8 10 3 1 3 2 3 1 0 0.59 0.91 1.00 260 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(1), ACO2(3), ACSS1(1), IDH1(1), MDH2(2), SUCLA2(1) 10182081 13 13 13 3 3 3 2 4 1 0 0.28 0.92 1.00 261 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH11(2), RDH12(1), RDH14(1) 3622515 4 4 4 2 0 1 0 2 1 0 0.79 0.92 1.00 262 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(4), CD2(2), CD33(1), CD5(2), IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), ITGAX(4), TLR2(1), TLR4(8), TLR7(5), TLR9(1) 14287767 32 29 31 8 6 8 3 7 8 0 0.24 0.92 1.00 263 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), MTMR6(1), NFS1(1), TPK1(1) 4912323 4 4 4 1 0 3 1 0 0 0 0.53 0.92 1.00 264 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(1), JUN(1), KEAP1(1), MAPK1(1), MAPK14(1), MAPK8(2) 6891651 7 7 7 2 2 1 1 0 2 1 0.55 0.93 1.00 265 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD3G(1), CD4(2), ITGAL(1), ITGB2(3), PTPRC(1) 8599734 11 11 11 3 0 3 3 3 2 0 0.43 0.93 1.00 266 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(2), CAMK1G(1), HDAC9(3), MEF2A(1), MEF2C(2) 6323811 9 9 9 3 1 2 2 1 3 0 0.62 0.93 1.00 267 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1) 2774811 1 1 1 1 1 0 0 0 0 0 0.86 0.93 1.00 268 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(5), GNB1(1), PRKACA(1), PRKAR1A(1) 4554381 11 11 11 4 3 2 1 4 1 0 0.77 0.93 1.00 269 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), CD3G(1), IL2(1), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(1) 8187543 12 11 12 3 1 4 3 3 1 0 0.39 0.93 1.00 270 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(5), NFKB1(1), NFKBIA(1), RELA(1) 10032516 14 14 14 3 1 4 2 2 5 0 0.42 0.93 1.00 271 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(2), CDO1(1), CTH(3), GOT2(1), LDHC(1) 9442368 8 7 8 1 0 2 2 0 4 0 0.39 0.93 1.00 272 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), CASP8(3), DFFB(2), PRF1(2), SCAP(3), SREBF2(4) 13882674 15 14 15 2 1 8 2 1 3 0 0.073 0.94 1.00 273 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), GLB1(1), HEXB(1), LCT(6), ST3GAL1(1), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(1) 12360660 15 15 15 3 2 2 4 5 2 0 0.35 0.94 1.00 274 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(2), IL6(2), LDLR(1), LPL(1) 3987048 7 7 7 5 0 3 2 0 2 0 0.94 0.94 1.00 275 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), GBGT1(1), GLA(2), HEXB(1), ST3GAL1(1), ST3GAL4(1), ST8SIA1(1) 7505628 10 10 9 4 1 2 1 2 4 0 0.62 0.94 1.00 276 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), IDI1(2), SQLE(1) 3343158 5 5 5 4 1 1 2 0 1 0 0.97 0.95 1.00 277 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1) 3762954 2 2 2 4 0 0 0 0 2 0 1.00 0.95 1.00 278 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPOR(2), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(5), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4) 16707678 34 32 34 7 8 6 6 3 11 0 0.11 0.95 1.00 279 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(1), OGDH(2), SDHA(1), SUCLA2(1) 7334769 8 7 8 2 1 2 4 1 0 0 0.46 0.95 1.00 280 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(2), ACP6(1), ACPP(2), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHRS2(3), DHRS7(1), PON1(1), PON2(1), PON3(1) 13847691 30 24 29 7 7 5 10 4 4 0 0.22 0.95 1.00 281 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH5A1(1), CAD(7), CPS1(5), EPRS(2), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(1), GLS(1), GMPS(1), GOT2(1), GPT2(2), GSS(1), PPAT(1), QARS(2) 25419459 36 33 36 4 3 7 13 10 3 0 0.021 0.95 1.00 282 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), TNFSF13B(1), TRAF3(1), TRAF6(2) 11171238 9 9 9 1 1 3 1 1 3 0 0.18 0.95 1.00 283 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(4), ESR1(2), GREB1(2), MTA3(2) 8166756 10 10 10 3 0 5 3 1 1 0 0.36 0.95 1.00 284 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), JUN(1), MAPK14(1), THBS1(4) 5482698 7 6 7 3 0 0 1 4 2 0 0.91 0.95 1.00 285 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPN1(3), CDK5(1), MAPT(1), PPP2CA(1) 7232862 8 8 8 2 2 2 2 1 1 0 0.57 0.96 1.00 286 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), GBGT1(1), GLA(2), HEXB(1), ST3GAL1(1), ST8SIA1(1) 7963956 11 11 10 5 1 1 3 2 4 0 0.78 0.96 1.00 287 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(2), AASS(3) 3628599 5 5 5 3 1 1 2 0 1 0 0.93 0.96 1.00 288 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(1), AASDHPPT(2), AASS(3) 5308290 6 6 6 3 1 1 2 0 2 0 0.93 0.96 1.00 289 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN2(8), ACTN3(1), ACTN4(4), ARHGAP5(3), CD99(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTNND1(1), CYBB(1), ESAM(2), EZR(2), F11R(1), GNAI1(1), GNAI2(1), GRLF1(5), ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), ITK(4), MAPK14(1), MLLT4(9), MMP9(1), MSN(1), MYL7(1), NCF1(1), NCF2(2), NOX1(1), NOX3(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(5), PLCG2(2), PRKCG(2), PTK2(3), PTK2B(3), PTPN11(1), PXN(1), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOA(2), ROCK1(1), ROCK2(2), SIPA1(1), TXK(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(2), VCL(3) 95524884 333 262 170 57 25 90 48 125 45 0 7.72e-07 0.96 1.00 290 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3) 4635501 9 9 9 3 2 5 0 1 1 0 0.61 0.96 1.00 291 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(2), JAK2(5), PTPRU(5), REG1A(1), STAT1(1) 8791380 14 14 14 4 2 2 2 3 5 0 0.73 0.96 1.00 292 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(1), AOC2(1), AOC3(2), CES1(2), ESD(1) 4369833 7 7 7 3 2 1 3 0 1 0 0.68 0.96 1.00 293 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(1) 3398421 2 2 2 2 0 0 0 1 1 0 0.93 0.96 1.00 294 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(3), BCAT2(2), COASY(3), DPYD(1), DPYS(1), ENPP1(4), ENPP3(2), ILVBL(2), PANK2(1), PANK4(3), UPB1(3), VNN1(3) 13100880 28 27 28 7 5 4 6 8 5 0 0.39 0.97 1.00 295 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(3), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 8765523 14 14 14 4 2 5 2 2 3 0 0.46 0.97 1.00 296 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(4), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(4), PFKP(4), PGD(2), PGLS(2), PGM1(2), PGM3(1), PRPS2(1), TKT(1) 14936220 28 27 28 7 11 4 3 6 4 0 0.18 0.97 1.00 297 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(2), DFFB(2), GZMA(1), HMGB2(1), PRF1(2), SET(1) 8268156 10 9 10 3 1 2 2 2 3 0 0.67 0.97 1.00 298 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(1), CD3G(1), HLA-A(6), ITGAL(1), ITGB2(3), PRF1(2) 6501768 16 14 15 6 3 3 2 4 4 0 0.64 0.97 1.00 299 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(2) 4405830 2 2 2 1 1 0 0 0 1 0 0.81 0.97 1.00 300 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(3), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), PC(3), PCK1(1), SDHA(1), SDHB(1), SUCLA2(1) 15959346 18 17 18 3 4 3 5 5 1 0 0.16 0.97 1.00 301 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), EGR1(1), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 6272604 10 10 10 4 2 3 1 3 1 0 0.57 0.97 1.00 302 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(2) 4551339 6 6 6 3 2 1 1 1 1 0 0.86 0.97 1.00 303 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1) 8276775 6 6 6 1 1 2 3 0 0 0 0.42 0.97 1.00 304 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT3(2), GALNT4(1), GALNT7(2), GALNT9(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(4) 11218896 14 14 14 8 1 2 3 2 6 0 0.91 0.97 1.00 305 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(2), CMAS(1), CTBS(1), CYB5R1(2), GFPT1(1), GFPT2(3), GNE(3), GNPNAT1(1), HEXB(1), HK1(1), HK3(2), MTMR2(1), MTMR6(1), NAGK(1), NANS(1), PGM3(1), RENBP(1), UAP1(1) 22232457 26 25 26 3 3 5 6 9 3 0 0.043 0.98 1.00 306 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(3), CREB1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(2) 8786817 14 14 14 4 2 2 4 5 1 0 0.57 0.98 1.00 307 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(3), C5(3), C6(4), C7(5), IL1A(1), IL6(2), ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELP(5), SELPLG(1), VCAM1(2) 18880173 33 30 33 8 6 7 7 7 6 0 0.17 0.98 1.00 308 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), GRB2(1), PTPRA(1) 7097493 9 9 9 3 3 0 4 1 1 0 0.66 0.98 1.00 309 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), GNAQ(1), GNAS(5), GNB1(1), LIMK1(3), MAP2K1(1), MAPK1(1), MAPK3(1), NOX1(1), PIK3C2G(2), PLCB1(4), PTK2(3), RAF1(1), ROCK2(2) 19387680 28 27 28 5 5 9 5 6 3 0 0.14 0.98 1.00 310 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 10151661 10 10 10 3 2 3 5 0 0 0 0.54 0.99 1.00 311 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 DFFB(2), HMGB2(1), TOP2A(1) 8107437 4 4 4 0 0 2 1 1 0 0 0.32 0.99 1.00 312 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(3), IGF1(1), IL1A(1), IL6(2), KITLG(2), TGFB3(1) 6551454 10 8 10 4 2 2 2 2 2 0 0.68 0.99 1.00 313 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(1), ELK1(2), FPR1(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(46), MAPK1(1), MAPK14(1), MAPK3(1), NCF1(1), NCF2(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(2), PLCB1(4), PPP3CA(3), PPP3CB(3), RAF1(1), RELA(1) 29322852 88 75 87 20 7 11 15 14 26 15 0.50 0.99 1.00 314 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), GRB2(1), IL6(2), IL6R(1), IL6ST(3), JAK1(2), JAK2(5), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), PTPN11(1), RAF1(1), SHC1(1), SOS1(4), SRF(1), STAT3(1) 18178485 31 29 31 6 5 4 9 5 8 0 0.22 0.99 1.00 315 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2), LTA(1) 7216638 10 9 10 5 2 2 1 2 3 0 0.84 0.99 1.00 316 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 EGF(2), EGFR(5), ETS1(2), ETS2(4), HOXA7(1), IKBKB(3), JUN(1), MAP2K1(1), MAP2K3(1), MAP2K4(20), MAP2K7(1), MAP3K1(46), MAP3K5(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKBIA(1), PPP2CA(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), RAF1(1), RELA(1), RIPK1(3), SP1(2), TNFRSF1A(1) 37109358 112 93 110 26 10 14 13 19 41 15 0.45 0.99 1.00 317 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(6), NRG3(2), PSEN1(1) 6965673 9 9 9 3 0 4 4 1 0 0 0.59 0.99 1.00 318 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(3), DHRS7(1), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), WBSCR22(2) 11206728 26 23 26 7 6 7 7 1 5 0 0.26 0.99 1.00 319 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(12), GRB2(1), IL2RG(1), IL4R(1), IRS1(1), JAK1(2), JAK3(2), SHC1(1), STAT6(1) 11131185 22 21 12 6 2 12 2 4 2 0 0.21 0.99 1.00 320 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(3), ACACB(8), FASN(3), MCAT(1), OLAH(1) 12471186 16 16 16 4 6 0 7 2 1 0 0.40 0.99 1.00 321 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(2), GFPT1(1), GNE(3), HEXB(1), HK1(1), HK3(2), PGM3(1), RENBP(1), UAP1(1) 13241319 14 14 14 3 3 1 3 5 2 0 0.40 0.99 1.00 322 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 6444984 5 5 5 2 0 2 3 0 0 0 0.72 0.99 1.00 323 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(2), GLS(1) 4389606 3 3 3 3 1 0 1 0 1 0 0.96 0.99 1.00 324 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), GRB2(1), IL3RA(1), JAK2(5), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4) 13669734 24 24 24 6 6 3 4 3 8 0 0.26 0.99 1.00 325 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ADC(1), ALDH5A1(1), CAD(7), CPS1(5), EARS2(3), EPRS(2), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(1), GFPT2(3), GLS(1), GLUD2(1), GMPS(1), GNPNAT1(1), GOT2(1), GPT2(2), GSS(1), NAGK(1), PPAT(1), QARS(2) 30338880 46 42 46 6 4 9 15 15 3 0 0.015 0.99 1.00 326 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(2), IL6R(1), JAK1(2), JAK2(5), JAK3(2), PTPRU(5), REG1A(1), STAT3(1) 11702574 19 19 19 8 4 2 3 3 7 0 0.85 0.99 1.00 327 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCR5(1), GNAQ(1), JUN(1), MAPK14(1), MAPK8(2), PLCG1(5), PTK2B(3) 10322013 14 14 14 5 2 2 5 0 5 0 0.67 0.99 1.00 328 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(3), HMBS(1), PPOX(1) 5985642 5 5 5 2 2 0 3 0 0 0 0.85 0.99 1.00 329 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 127 ACACA(3), ACACB(8), AKT1(12), AKT2(1), AKT3(3), ARAF(1), BAD(1), BRAF(3), CBL(1), CBLB(9), CBLC(3), CRKL(1), ELK1(2), EXOC7(2), FASN(3), G6PC2(2), GCK(2), GRB2(1), GYS1(5), GYS2(1), IKBKB(3), INPP5D(3), INSR(2), IRS1(1), IRS4(4), KRAS(4), LIPE(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MKNK2(1), PCK1(1), PCK2(1), PDE3A(7), PDE3B(1), PFKM(4), PFKP(4), PHKA1(1), PHKA2(4), PHKB(2), PHKG2(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PKLR(1), PPARGC1A(2), PPP1R3A(7), PPP1R3B(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(1), PRKAG2(1), PRKAG3(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(1), PRKX(1), PTPRF(5), PYGB(3), PYGL(1), PYGM(4), RAF1(1), RAPGEF1(3), RHEB(1), RPS6(2), RPS6KB2(4), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS4(1), SORBS1(4), SOS1(4), SOS2(2), TRIP10(4), TSC1(3), TSC2(2) 122263557 409 287 235 70 46 116 63 141 43 0 7.70e-09 1.00 1.00 330 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT1(2), B4GALT3(1), DPAGT1(2), MAN1A1(1), MAN1B1(1), MGAT3(1), MGAT4B(1), MGAT5(2), RPN1(2) 14519973 14 14 14 3 2 3 4 2 3 0 0.37 1.00 1.00 331 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 ARSA(1), ARSB(3), ARSE(2), ASAH1(1), GAL3ST1(1), GLA(2), GLB1(1), LCT(6), NEU2(1), PPAP2A(1), PPAP2C(2), SMPD2(2), SPTLC1(1), SPTLC2(2) 17037228 26 22 26 5 7 4 8 5 2 0 0.16 1.00 1.00 332 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(1), NDUFA1(1), SDHA(1), SDHB(1), UQCRC1(2) 4929561 7 7 7 5 2 0 2 2 1 0 0.96 1.00 1.00 333 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(2), JUN(1), MAPK3(1), OPRK1(2), POLR2A(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 9807915 12 12 12 4 4 0 5 2 1 0 0.67 1.00 1.00 334 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), CASP1(1), CASP2(3), CASP6(2), CASP8(3), DFFB(2), LMNB1(1), PRF1(2) 14685762 16 16 16 4 1 6 3 3 3 0 0.37 1.00 1.00 335 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(2), CSF1(2), HLA-DRB1(4), IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2), LTA(1), TGFB3(1) 9655308 19 18 19 7 2 5 4 4 4 0 0.58 1.00 1.00 336 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(3), HMBS(1) 6471855 4 4 4 2 2 0 2 0 0 0 0.87 1.00 1.00 337 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(5), JAK3(2), PTPRU(5), REG1A(1), SOAT1(1) 10616580 16 16 16 5 3 3 2 3 5 0 0.64 1.00 1.00 338 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(4), CREB1(1), EDN1(2), EP300(3), HIF1A(1), JUN(1), NOS3(2), P4HB(1) 13061334 17 16 16 5 1 4 3 3 6 0 0.67 1.00 1.00 339 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(2), EP300(3), HDAC3(2), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF6(2) 16605771 19 19 18 4 2 6 4 2 5 0 0.20 1.00 1.00 340 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(1), ARG1(2), ARG2(1), ASL(3), CKMT2(2), CPS1(5), GATM(4), OTC(1) 13674297 21 21 21 5 2 4 8 6 1 0 0.37 1.00 1.00 341 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(3), IARS(6), LARS(1), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1) 7646574 17 15 17 6 3 5 4 3 2 0 0.62 1.00 1.00 342 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), GRB2(1), PTK2B(3), SHC1(1), SOS1(4) 6669078 10 10 10 4 2 3 3 1 1 0 0.69 1.00 1.00 343 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(2), PTPRU(5), REG1A(1), STAT1(1), STAT2(2), TYK2(4) 9504729 17 17 16 5 4 4 2 5 2 0 0.45 1.00 1.00 344 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(2), CTH(3), GGT1(2), MAT1A(1), MAT2B(1), PAPSS1(2), SEPHS1(1) 9499152 13 13 13 7 4 3 2 0 4 0 0.75 1.00 1.00 345 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(1), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), ASS1(1), CPS1(5), GATM(4), MAOA(2), MAOB(1), OTC(1), SAT1(2), SAT2(1) 22414977 38 36 38 9 4 8 14 9 3 0 0.22 1.00 1.00 346 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD86(2), HLA-DRB1(4), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), IL2(1), IL4R(1) 9285198 14 14 14 7 0 1 5 5 3 0 0.90 1.00 1.00 347 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 11 GLB1(1), HEXB(1), LCT(6), MANBA(1), NEU2(1) 11416626 10 10 10 3 1 1 3 3 2 0 0.70 1.00 1.00 348 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(2), ADCY3(2), ADCY9(5), ARF1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ERO1L(3), GNAS(5), PDIA4(2), PLCG1(5), PLCG2(2), SEC61A1(2), TRIM23(2) 28196298 42 40 42 9 8 6 15 5 8 0 0.15 1.00 1.00 349 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), ACAT1(1), ECHS1(1), EHHADH(2), HADHB(1) 6467292 7 7 7 6 0 1 2 3 1 0 0.97 1.00 1.00 350 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), GNAS(5), PLCE1(7), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAP2B(1) 10785918 19 19 19 6 4 3 3 6 3 0 0.65 1.00 1.00 351 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(4), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME3(2), PGK1(2), PKLR(1), TKT(1), TKTL1(1), TKTL2(1), TPI1(2) 15269319 21 21 21 5 5 8 6 1 1 0 0.12 1.00 1.00 352 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(3), C5(3), C6(4), C7(5), C9(1) 9793719 16 16 16 5 3 5 3 2 3 0 0.48 1.00 1.00 353 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(2), ARG2(1), ASL(3), ASS1(1), CKMT2(2), CPS1(5), DAO(1), EPRS(2), GATM(4), GLUD2(1), GOT2(1), NOS1(3), NOS3(2), OTC(1), P4HA2(1), P4HA3(1), PARS2(1), PYCR2(1), PYCRL(3), RARS(2), RARS2(2) 27808950 40 39 39 8 7 7 17 7 2 0 0.12 1.00 1.00 354 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(1), NOTCH1(2), PSEN1(1) 7103577 5 5 5 2 0 2 1 2 0 0 0.71 1.00 1.00 355 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(4), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), FUT2(2), FUT3(4), FUT5(1), ST3GAL6(1), ST8SIA1(1) 11992071 21 21 20 7 4 5 3 6 3 0 0.38 1.00 1.00 356 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CAMKK1(3), CAMKK2(2), CREB1(1) 8972379 14 14 14 8 3 2 1 5 3 0 0.93 1.00 1.00 357 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(2), WASF1(3), WASL(1) 6290856 9 9 9 7 1 2 5 0 1 0 0.99 1.00 1.00 358 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(1), CD3G(1), CD4(2), HLA-DRB1(4), PTPRC(1), ZAP70(1) 6334458 10 10 10 6 1 3 2 3 1 0 0.82 1.00 1.00 359 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CRY1(1), CSNK1E(2), PER1(3) 6447519 7 7 7 4 1 1 2 2 1 0 0.91 1.00 1.00 360 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(1), CHST11(1), PAPSS1(2), SULT1A1(1), SULT1A2(1), SULT1E1(2), SUOX(3) 6452082 11 11 11 7 3 5 0 2 1 0 0.89 1.00 1.00 361 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(4), RAF1(1), RELA(1) 11439948 13 12 13 4 3 5 1 1 3 0 0.42 1.00 1.00 362 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKAR2A(1), PRKAR2B(1) 7605000 7 7 7 3 1 4 1 1 0 0 0.62 1.00 1.00 363 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(2), EP300(3), ESR1(2), MAPK1(1), MAPK3(1), PELP1(2) 11543883 11 11 10 5 1 4 2 0 4 0 0.77 1.00 1.00 364 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(4), G6PD(1), GCLC(2), GCLM(1), GGT1(2), GPX5(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTT1(1), GSTZ1(1), IDH1(1), OPLAH(4), TXNDC12(1) 17365257 26 25 25 6 7 4 6 6 3 0 0.19 1.00 1.00 365 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(3), CPT1A(3), LEPR(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1) 11043981 15 15 15 7 6 1 4 1 3 0 0.90 1.00 1.00 366 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(2), CD14(1), CDH1(33), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCK1(1), NCK2(1), NCL(2), RHOA(2), ROCK1(1), ROCK2(2), TLR4(8), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), WAS(2), WASL(1) 39342693 87 77 83 20 7 10 20 8 42 0 0.29 1.00 1.00 367 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(2), CD14(1), CDH1(33), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCK1(1), NCK2(1), NCL(2), RHOA(2), ROCK1(1), ROCK2(2), TLR4(8), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), WAS(2), WASL(1) 39342693 87 77 83 20 7 10 20 8 42 0 0.29 1.00 1.00 368 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 29 AGPAT3(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(5), ENPP6(1), PAFAH1B1(2), PAFAH1B3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLD1(1), PPAP2A(1), PPAP2C(2) 17659824 34 31 32 9 3 9 9 10 3 0 0.27 1.00 1.00 369 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(2), GNAI1(1), GNB1(1), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(4), PTGS1(1), PTK2(3), RAF1(1), SYK(2), TBXAS1(1) 18573438 35 29 34 9 3 9 17 4 2 0 0.35 1.00 1.00 370 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(1), DLAT(1), DLD(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(2), PC(3), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK4(2), PDP2(1), SDHA(1), SDHB(1), SUCLA2(1) 22026108 29 28 29 6 7 7 8 6 1 0 0.12 1.00 1.00 371 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(1), ACO2(3), CLYBL(2), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(2), OGDHL(2), PC(3), PCK1(1), PCK2(1), SDHA(1), SDHB(1), SUCLA2(1) 23066979 29 27 29 6 6 5 8 8 2 0 0.13 1.00 1.00 372 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CD4(2), CXCR3(2), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), IL2(1), IL4R(1), TGFB3(1) 15566421 22 21 22 9 1 6 3 6 6 0 0.68 1.00 1.00 373 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), GRB2(1), IL2(1), IL2RB(1), IL2RG(1), JAK1(2), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4), SYK(2) 17964531 31 29 31 8 8 3 7 5 8 0 0.25 1.00 1.00 374 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1) 9978774 10 9 10 8 2 1 2 2 3 0 0.97 1.00 1.00 375 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(2), EP300(3), NCOA3(6), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RARA(1) 15839187 17 15 16 6 2 2 5 2 6 0 0.80 1.00 1.00 376 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(1), CALCRL(2), CD97(5), CRHR1(3), CRHR2(1), ELTD1(4), EMR1(2), EMR2(6), GHRHR(1), GIPR(1), GPR64(6), LPHN1(2), LPHN2(6), LPHN3(6), VIPR1(1) 21354333 48 45 48 12 5 5 21 7 9 1 0.27 1.00 1.00 377 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(5), GNB1(1), PPP2CA(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 11333478 19 18 19 8 6 3 3 5 2 0 0.85 1.00 1.00 378 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), EIF5(2) 8613930 7 7 7 3 1 2 3 0 1 0 0.88 1.00 1.00 379 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(5), CTH(3), GLS(1), HAL(2) 14374464 20 20 20 6 1 3 7 4 5 0 0.54 1.00 1.00 380 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1), MASP1(1), MASP2(1), MBL2(1) 15956811 21 21 21 6 5 6 3 3 4 0 0.31 1.00 1.00 381 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), FDXR(3) 12375363 11 11 10 4 3 1 4 1 2 0 0.72 1.00 1.00 382 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(1), IDI1(2), LSS(2), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1) 10188672 12 12 12 9 2 1 4 3 2 0 0.98 1.00 1.00 383 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), LSS(2), NQO1(1), NQO2(1), PMVK(1), SQLE(1), VKORC1(1) 8503404 12 12 12 7 3 2 4 2 1 0 0.91 1.00 1.00 384 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(3), DHRS7(1), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(1) 12345957 16 15 16 5 3 4 3 4 2 0 0.50 1.00 1.00 385 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ACAD9(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), LIPA(1), RDH11(2), RDH12(1), RDH14(1), SLC27A5(2), SOAT1(1), SRD5A1(1), SRD5A2(3) 24276174 30 29 30 8 3 9 9 5 4 0 0.31 1.00 1.00 386 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CSF1(2), IL6R(1), SELL(4), SPN(2), TNFRSF1A(1), TNFRSF8(1) 10020348 13 13 12 5 1 2 7 1 2 0 0.71 1.00 1.00 387 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(3), CREB1(1), CREB3(1), DUSP4(1), DUSP6(1), DUSP9(1), EEF2K(3), GRB2(1), MAP2K1(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), MKNK2(1), MOS(2), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(4), SOS2(2), TRAF3(1) 22739964 36 33 36 9 8 6 11 5 6 0 0.24 1.00 1.00 388 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(2), HADH(1), HSD17B10(1), HSD17B4(4), NTAN1(1), SIRT1(1), SIRT7(1), VNN2(3) 9111297 15 15 15 6 0 4 7 3 1 0 0.81 1.00 1.00 389 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), ATG7(2), GABARAP(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), PIK3C3(2), PIK3R4(3), PRKAA1(1), PRKAA2(3), ULK1(2), ULK2(1) 16487640 27 26 27 8 2 8 9 4 4 0 0.56 1.00 1.00 390 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(1), ARSB(3), ARSE(2), CYP11B1(2), CYP11B2(3), HSD11B1(2), HSD17B2(1), HSD3B2(3), SRD5A1(1), SRD5A2(3), SULT1E1(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2) 20441226 33 29 33 9 5 6 14 6 2 0 0.34 1.00 1.00 391 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(2), EP300(3), LPL(1), NCOA1(1), NCOA2(1), PPARG(1) 14134146 9 9 8 5 0 2 3 0 4 0 0.89 1.00 1.00 392 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1) 12920388 18 18 18 6 4 6 3 2 3 0 0.46 1.00 1.00 393 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(3), CAP1(2), CCNB1(2), CDC25C(1), GNAI1(1), GNAS(5), GNB1(1), MAPK1(1), MAPK3(1), MYT1(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1) 15401139 24 23 24 8 6 4 8 4 2 0 0.57 1.00 1.00 394 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABARAP(1), GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), GPHN(1), NSF(1), UBQLN1(1) 9217767 15 15 15 6 2 3 4 5 1 0 0.72 1.00 1.00 395 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(5), GNAQ(1), GNB1(1), MYLK(6), PLCB1(4), ROCK1(1) 15895464 21 21 21 6 3 4 7 3 4 0 0.43 1.00 1.00 396 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CR1(8), CR2(2), HLA-DRB1(4), ITGAL(1), ITGB2(3), PTPRC(1) 11269596 19 19 19 7 0 4 7 6 2 0 0.65 1.00 1.00 397 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 GNAQ(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PLCG1(5), PPP3CA(3), PPP3CB(3), SP1(2), SP3(3) 14982357 25 23 25 9 1 5 8 7 4 0 0.74 1.00 1.00 398 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(5), CTH(3), GLS(1), GLUD2(1), HAL(2) 16039959 21 21 21 7 1 3 7 5 5 0 0.61 1.00 1.00 399 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(2), EGFR(5), HGS(3), TF(1), TFRC(1) 9799296 15 15 15 7 4 2 5 3 1 0 0.81 1.00 1.00 400 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(1), MBTPS1(1), MBTPS2(2), SCAP(3), SREBF2(4) 9118902 12 12 12 8 0 4 6 1 1 0 0.92 1.00 1.00 401 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(1), CBS(2), CTH(3), DNMT1(1), DNMT3A(3), DNMT3B(1), MAT1A(1), MAT2B(1), MTR(5) 13484679 19 18 19 8 4 2 6 3 4 0 0.74 1.00 1.00 402 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6) 12791103 15 15 15 6 1 2 6 3 3 0 0.80 1.00 1.00 403 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1), MASP1(1) 15421419 19 19 19 6 4 6 3 2 4 0 0.41 1.00 1.00 404 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), DHRS2(3), DHRS7(1), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(1) 18805644 22 21 22 6 5 5 6 4 2 0 0.38 1.00 1.00 405 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CRY1(1), CSNK1E(2), NPAS2(1), NR1D1(2), PER1(3), PER2(3), PER3(2) 12820002 15 15 15 7 4 1 3 4 3 0 0.85 1.00 1.00 406 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(9), MAP2(7), PPP2CA(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1) 13840593 20 20 20 7 1 3 10 4 2 0 0.85 1.00 1.00 407 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(2), ELOVL5(3), ELOVL6(2), FADS2(4), FASN(3), SCD(1) 11350716 18 18 18 7 2 3 9 2 2 0 0.75 1.00 1.00 408 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), SRD5A1(1), SRD5A2(3) 17706468 24 22 24 8 2 7 10 3 2 0 0.59 1.00 1.00 409 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1) 11743641 8 8 8 4 1 1 3 1 2 0 0.89 1.00 1.00 410 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1) 11743641 8 8 8 4 1 1 3 1 2 0 0.89 1.00 1.00 411 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1) 11743641 8 8 8 4 1 1 3 1 2 0 0.89 1.00 1.00 412 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), NOS1(3), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 19841952 40 38 39 11 9 4 18 5 4 0 0.30 1.00 1.00 413 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), HGSNAT(3), HPSE(4), HPSE2(1), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(6), MAN2B1(2), MAN2B2(3), MANBA(1), NAGLU(1), NEU2(1) 25434162 36 33 36 9 5 5 10 13 3 0 0.37 1.00 1.00 414 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), IMPDH1(2), POLB(1), POLG(1), PRPS2(1), RRM1(1) 9760764 8 8 8 4 1 1 5 0 1 0 0.87 1.00 1.00 415 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2) 37323312 59 55 59 12 14 15 17 9 4 0 0.019 1.00 1.00 416 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2) 37323312 59 55 59 12 14 15 17 9 4 0 0.019 1.00 1.00 417 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(2), ACPP(2), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(3), PON1(1) 22431708 47 38 46 11 10 8 15 8 6 0 0.13 1.00 1.00 418 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), ESCO1(3), GOT2(1), HPD(1), LPO(5), MAOA(2), MAOB(1), MPO(2), MYST3(2), MYST4(6), PNPLA3(1), TPO(6) 25729236 44 41 44 10 9 7 14 7 7 0 0.13 1.00 1.00 419 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), ANXA4(1), ANXA6(2), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(1), HSD11B1(2), PLA2G4A(7), PTGDR(1), PTGDS(1), PTGFR(1), PTGIS(1), PTGS1(1), PTGS2(1), S100A6(1), TBXAS1(1) 15539043 26 24 25 8 3 5 12 5 1 0 0.58 1.00 1.00 420 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), AP2A1(4), AP2M1(3), BIN1(1), DNM1(2), EPS15(2), PPP3CA(3), PPP3CB(3), SYNJ2(1) 17506203 21 21 21 9 2 2 8 4 5 0 0.86 1.00 1.00 421 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), DRD2(1), GRM1(3), PLCB1(4), PPP2CA(1), PPP3CA(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1) 12191322 16 15 16 6 3 3 6 3 1 0 0.68 1.00 1.00 422 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(1), GPRC5A(1), GRM1(3), GRM2(1), GRM3(7), GRM4(1), GRM5(1), GRM8(1) 14653821 21 19 21 7 6 4 7 2 2 0 0.31 1.00 1.00 423 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(1), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2) 13449189 14 14 14 7 1 1 5 5 2 0 0.87 1.00 1.00 424 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), BHMT(1), CBS(2), CTH(3), DNMT1(1), DNMT3A(3), DNMT3B(1), MAT1A(1), MAT2B(1), MTAP(1), MTR(5) 16007511 21 20 21 9 4 4 6 3 4 0 0.74 1.00 1.00 425 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(4), BCHE(2), CES1(2), CYP3A4(3), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2) 17328246 19 19 19 7 4 2 6 5 2 0 0.66 1.00 1.00 426 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 GLB1(1), HEXB(1), LCT(6), MAN2B1(2), MAN2B2(3), MANBA(1), NEU2(1) 14313624 15 15 15 6 1 1 4 7 2 0 0.83 1.00 1.00 427 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(2), NCK1(1), NCKAP1(3), NTRK1(3), PIR(1), WASF1(3), WASF3(1), WASL(1) 11829324 18 18 18 7 3 3 8 3 1 0 0.81 1.00 1.00 428 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(2), EXTL3(3), GLCE(2), HS2ST1(2), HS3ST2(1), HS3ST5(3), HS6ST1(1), HS6ST2(3), HS6ST3(1), NDST3(1) 15655146 22 21 22 9 3 2 6 8 3 0 0.84 1.00 1.00 429 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(4), ITGA1(4), ITGB1(2), L1CAM(2), LYN(4), SELP(5) 12020970 23 23 23 9 6 6 8 3 0 0 0.65 1.00 1.00 430 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(1), MRPS7(2), RPL13A(2), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL3L(1), RPL41(1), RPL7(1), RPS10(1), RPS16(1), RPS2(1), RPS21(2), RPS27(1), RPS5(3), RPS6(2), RPSA(1) 17267406 27 26 27 7 2 5 12 6 2 0 0.44 1.00 1.00 431 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(12), CREB1(1), CREB3(1), DUSP10(1), EEF2K(3), ELK1(2), IL1R1(1), MAP2K3(1), MAP2K4(20), MAP3K10(4), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAPK1(1), MAPK14(1), MKNK2(1), MYEF2(2), NFKB1(1), NR2C2(1), SRF(1), TRAF6(2) 25634427 63 58 51 17 7 19 14 6 17 0 0.32 1.00 1.00 432 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(2), EP300(3), IKBKB(3), MAP2K3(1), MAP3K7(1), MAPK14(1), NFKB1(1), NFKBIA(1), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1) 22611693 20 18 19 7 2 5 6 1 6 0 0.56 1.00 1.00 433 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(1), CYP1A2(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP3A4(3), CYP3A43(1), CYP3A7(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), RDH11(2), RDH12(1), RDH14(1) 18373680 37 34 35 10 4 9 9 8 7 0 0.24 1.00 1.00 434 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(6), DYRK1B(1), GLI2(3), GLI3(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SMO(2), SUFU(2) 11980410 21 18 21 9 5 5 8 2 1 0 0.67 1.00 1.00 435 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), HDAC3(2), NCOA1(1), NCOA2(1), NCOA3(6), NCOR2(3), POLR2A(2), RARA(1), TBP(1) 19566144 19 19 19 7 2 2 7 4 4 0 0.82 1.00 1.00 436 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GOT2(1), GPI(2), HK1(1), HK3(2), LDHC(1), MDH2(2), PC(3), PCK1(1), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PFKM(4), PFKP(4), PGK1(2), PKLR(1), TPI1(2) 32638632 45 43 45 10 12 12 10 6 5 0 0.038 1.00 1.00 437 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(3), AXIN1(1), BTRC(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CCND1(1), CCND3(3), CER1(1), CHD8(2), CREBBP(2), CSNK1A1L(3), CSNK1E(2), CSNK2A1(1), CSNK2A2(1), CTBP2(1), CUL1(1), DAAM1(1), DAAM2(3), DKK2(1), DKK4(1), DVL1(2), DVL3(1), EP300(3), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), JUN(1), LRP6(2), MAP3K7(1), MAPK10(1), MAPK8(2), MYC(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NKD1(1), NKD2(2), NLK(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PORCN(1), PPP2CA(1), PPP2CB(2), PPP3CA(3), PPP3CB(3), PRICKLE1(2), PRICKLE2(2), PRKACA(1), PRKCG(2), PRKX(1), PSEN1(1), RHOA(2), ROCK1(1), ROCK2(2), RUVBL1(1), SFRP1(3), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(2), SMAD4(1), TBL1X(4), TBL1XR1(8), TCF7(3), TCF7L2(2), TP53(187), VANGL1(2), VANGL2(3), WIF1(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1) 120101202 351 260 275 64 60 49 68 72 99 3 0.000024 1.00 1.00 438 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(1), CCKBR(1), CCR2(4), CCR3(1), CCR5(1), CELSR1(4), CELSR2(3), CELSR3(4), CHRM2(2), CHRM3(1), CXCR3(2), DRD4(1), EDNRA(1), EMR2(6), EMR3(2), F2R(2), FSHR(4), GHRHR(1), GPR116(2), GPR132(1), GPR133(2), GPR143(3), GPR17(1), GPR56(2), GPR77(2), GPR84(2), GRM1(3), GRPR(1), HRH4(1), LGR6(2), LPHN2(6), LPHN3(6), LTB4R2(1), OR8G2(1), P2RY11(1), P2RY13(2), PTGFR(1), SMO(2), SSTR2(1), TAAR5(3), TSHR(4) 50133174 93 80 93 21 18 22 21 21 11 0 0.0078 1.00 1.00 439 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(3), ACACB(8), ACAT1(1), ACSS1(1), ACYP1(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLAT(1), DLD(1), HAGHL(1), LDHC(1), MDH2(2), ME2(2), ME3(2), PC(3), PCK1(1), PCK2(1), PDHA1(2), PDHA2(2), PDHB(1), PKLR(1) 35460594 42 39 42 9 8 11 14 6 3 0 0.082 1.00 1.00 440 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2E2(1), GTF2F2(1), GTF2H1(1), GTF2H3(1), GTF2I(1), TAF1(8), TAF1L(7), TAF4B(2), TAF5L(2), TAF6(1), TAF7(1), TBPL2(2) 27078870 28 27 27 7 5 6 7 6 4 0 0.34 1.00 1.00 441 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(5), ASH2L(3), CARM1(1), CTCFL(2), DOT1L(4), EED(2), EHMT1(3), EZH1(1), EZH2(1), FBXO11(1), HCFC1(7), KDM6A(4), MEN1(2), MLL(6), MLL2(8), MLL3(38), MLL4(5), MLL5(4), OGT(2), PAXIP1(3), PRDM2(2), PRDM6(1), PRDM7(1), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), RBBP5(1), SATB1(2), SETD1B(1), SETD2(5), SETD7(1), SETD8(1), SETDB1(7), SETMAR(2), SMYD3(4), SUV420H1(2), SUZ12(3), WHSC1(7), WHSC1L1(1) 94554993 151 128 150 28 16 26 38 21 50 0 0.053 1.00 1.00 442 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(1), BID(4), CASP6(2), CASP8(3), DFFB(2), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), SPTAN1(2) 25418445 20 19 20 5 3 8 1 2 6 0 0.24 1.00 1.00 443 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), EGF(2), EGFR(5), GRB2(1), MET(5), PDGFRA(3), SH3KBP1(1) 14905800 18 16 18 8 4 3 4 4 3 0 0.88 1.00 1.00 444 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(3), CPEB1(2), EGFR(5), ERBB2(8), ERBB4(6), ETS1(2), ETS2(4), ETV6(2), ETV7(1), FMN2(8), GRB2(1), KRAS(4), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH1(2), NOTCH2(7), NOTCH3(3), PIWIL1(8), PIWIL2(4), PIWIL3(2), PIWIL4(2), RAF1(1), SOS1(4), SOS2(2), SPIRE1(1) 37167663 85 75 82 22 12 21 24 19 9 0 0.13 1.00 1.00 445 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), DARS(1), EPRS(2), FARS2(1), GARS(1), IARS(6), LARS(1), LARS2(2), NARS(1), QARS(2), RARS(2), SARS(2), TARS(4), WARS2(1) 24255894 30 29 30 9 3 7 11 5 4 0 0.55 1.00 1.00 446 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(12), AKT2(1), AKT3(3), ASAH1(1), BRAF(3), DAG1(1), DRD2(1), EGFR(5), EPHB2(2), GRB2(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), PI3(1), PIK3CB(4), PITX2(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), RAF1(1), RGS20(2), SHC1(1), SOS1(4), SOS2(2), STAT3(1), TERF2IP(2) 44704725 89 81 79 22 12 28 19 17 13 0 0.041 1.00 1.00 447 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), GAA(2), GALK2(1), GALT(1), GANAB(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(6), MGAM(9), PFKM(4), PFKP(4), PGM1(2), PGM3(1) 25033632 43 39 43 12 12 5 8 13 5 0 0.23 1.00 1.00 448 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(2), EPRS(2), GUSB(1), HMBS(1), PPOX(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2) 20820969 17 16 17 9 2 2 7 4 2 0 0.93 1.00 1.00 449 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), EGFR(5), F11R(1), GIT1(1), IGSF5(3), IKBKB(3), JUN(1), LYN(4), MAP2K4(20), MAPK10(1), MAPK14(1), MAPK8(2), MET(5), NFKB1(1), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(2), PLCG1(5), PLCG2(2), PTPN11(1), PTPRZ1(5), RELA(1), TCIRG1(1), TJP1(4) 54548130 89 81 88 20 11 15 27 7 28 1 0.19 1.00 1.00 450 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(12), AP2A1(4), AP2M1(3), ARF1(1), BAD(1), BTK(3), EEA1(3), GSK3A(1), LYN(4), PFKM(4), PFKP(4), PLCG1(5), PRKCE(1), PRKCZ(1), VAV2(1) 19715709 48 45 38 15 12 17 7 5 7 0 0.18 1.00 1.00 451 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN2(8), ACTN3(1), CAPN1(3), ITGA1(4), ITGB1(2), ITGB3(2), PTK2(3), PXN(1), SPTAN1(2), TLN1(9) 22364784 36 36 36 10 9 5 9 8 5 0 0.48 1.00 1.00 452 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(4), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(4), PFKP(4), PGD(2), PGLS(2), PGM1(2), PGM3(1), PRPS2(1), TKT(1), TKTL1(1), TKTL2(1) 18335655 30 29 30 10 11 4 4 7 4 0 0.42 1.00 1.00 453 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(3), PIGA(1), PIGB(1), PIGG(1), PIGQ(3), PIGW(2) 19066749 15 14 15 8 2 3 5 4 1 0 0.88 1.00 1.00 454 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(2), ALOX12B(1), ALOX5(1), CBR1(1), CBR3(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP4F2(1), DHRS4(1), GGT1(2), GPX5(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1) 30137601 43 41 41 11 6 9 16 6 6 0 0.13 1.00 1.00 455 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 68 B2M(2), CALR(1), CANX(1), CD4(2), CD8A(1), CIITA(3), CREB1(1), CTSB(1), CTSS(1), HLA-A(6), HLA-C(3), HLA-DMB(2), HLA-DQB1(2), HLA-DRB1(4), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), HSP90AA1(2), HSP90AB1(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR2DS4(1), KIR3DL2(4), KIR3DL3(1), KLRC1(2), KLRC3(1), LTA(1), NFYB(1), NFYC(1), RFXANK(1), TAP1(2) 29449095 71 58 70 21 8 17 24 9 13 0 0.36 1.00 1.00 456 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(1), BAD(1), CASP1(1), CASP2(3), CASP6(2), CASP8(3), CD40(1), CD40LG(1), DFFB(2), FAS(1), FASLG(1), IKBKE(1), LTA(1), NFKB1(1), NFKBIA(1), NGFR(1), NTRK1(3), PTPN13(4), RIPK1(3), SFRS2IP(2), TNFRSF1A(1), TRAF1(1), TRAF3(1), TRAF6(2) 32781606 39 37 39 10 4 17 7 4 7 0 0.12 1.00 1.00 457 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), DDX20(2), E2F1(2), E2F4(2), ETS1(2), ETS2(4), ETV3(2), HDAC2(3), HDAC5(2), JUN(1), NCOR2(3), RBL1(1), RBL2(1), SIN3A(3), SIN3B(2) 21072441 32 31 32 10 5 9 5 7 6 0 0.61 1.00 1.00 458 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), AMDHD1(2), AOC2(1), AOC3(2), ASPA(2), CARM1(1), CNDP1(2), DDC(1), FTCD(1), HAL(2), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), PRPS2(1), WBSCR22(2) 30204525 50 42 50 15 7 11 20 4 8 0 0.30 1.00 1.00 459 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AGK(2), AGPAT3(2), AGPAT6(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(1), DAK(3), DGAT1(1), DGAT2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), GK2(2), GLA(2), GLB1(1), GPAM(1), LCT(6), LIPA(1), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(1), PPAP2A(1), PPAP2C(2) 45173700 70 62 69 19 15 14 21 10 10 0 0.19 1.00 1.00 460 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(3), ACAT1(1), ACYP1(1), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLAT(1), DLD(1), HAGHL(1), LDHC(1), MDH2(2), ME2(2), ME3(2), PC(3), PCK1(1), PDHA1(2), PDHA2(2), PDHB(1), PKLR(1) 28015299 35 31 35 10 6 12 11 3 3 0 0.28 1.00 1.00 461 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(4), B3GALT4(2), CDR1(1), DGKI(6), IL6ST(3), RPL13A(2), RPL17(1), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL36(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(1), RPL7(1), RPLP2(1), RPS10(1), RPS14(1), RPS16(1), RPS2(1), RPS21(2), RPS27(1), RPS4X(1), RPS5(3), RPS6(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(4), RPSA(1), SLC36A2(1), TBC1D10C(2), UBC(7) 40286727 69 64 69 15 11 8 31 12 7 0 0.23 1.00 1.00 462 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(12), AKT2(1), AKT3(3), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(2), PLD1(1), PLD3(2) 34735584 63 55 53 17 8 23 11 10 10 1 0.093 1.00 1.00 463 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 ACHE(2), AGPAT3(2), AGPS(1), CDS1(2), CDS2(1), CHAT(1), CHKB(1), CLC(1), CPT1B(2), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), ETNK1(3), GNPAT(2), GPD1(2), GPD2(1), LCAT(1), LGALS13(1), PAFAH1B1(2), PCYT1A(1), PCYT1B(3), PLA2G2E(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB2(2), PLCG1(5), PLCG2(2), PPAP2A(1), PPAP2C(2) 38331228 68 62 65 18 11 12 21 16 8 0 0.23 1.00 1.00 464 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), DBH(4), DCT(1), DDC(1), FAH(1), GOT2(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(1), TPO(6), TYR(4) 24130665 44 42 44 15 9 6 18 6 5 0 0.58 1.00 1.00 465 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), B4GALT1(2), G6PC2(2), GAA(2), GALK2(1), GALT(1), GANC(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(6), MGAM(9), PFKM(4), PFKP(4), PGM1(2), PGM3(1), RDH11(2), RDH12(1), RDH14(1) 29738085 49 46 49 15 12 6 8 17 6 0 0.30 1.00 1.00 466 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(1), DDX41(2), DDX50(3), DDX51(1), DDX55(3), DDX56(1), DHX58(2), ENTPD7(3), EP400(2), ERCC3(2), FPGS(1), GCH1(1), IFIH1(1), MOV10L1(3), NUDT5(1), NUDT8(1), RAD54B(4), RAD54L(2), SETX(8), SKIV2L2(1), SMARCA2(4), SMARCA5(2) 48342957 61 52 60 14 12 11 19 10 9 0 0.14 1.00 1.00 467 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 34 ARSA(1), ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS1(2), ENPP7(1), GAL3ST1(1), GLA(2), GLB1(1), LCT(6), NEU2(1), PPAP2A(1), PPAP2C(2), SGMS1(1), SGPP1(1), SGPP2(1), SMPD2(2), SMPD3(1), SPHK2(2), SPTLC1(1), SPTLC2(2) 25688169 34 32 34 11 7 6 11 7 3 0 0.47 1.00 1.00 468 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(5), ELK1(2), GNAS(5), GNB1(1), GRB2(1), IGF1R(2), ITGB1(2), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(3), PPP2CA(1), PTPRR(2), RAF1(1), RPS6KA1(1), RPS6KA5(1), SHC1(1), SOS1(4), STAT3(1) 25173057 42 41 42 12 10 12 9 8 3 0 0.26 1.00 1.00 469 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(8), CARM1(1), CCND1(1), CREBBP(2), EP300(3), ERCC3(2), ESR1(2), GRIP1(1), HDAC1(2), HDAC2(3), HDAC3(2), HDAC4(1), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(3), NRIP1(1), PELP1(2), POLR2A(2), TBP(1) 36497916 44 41 43 12 3 12 11 4 14 0 0.36 1.00 1.00 470 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), G6PC2(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGAM4(1), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2) 44603832 60 55 60 16 15 14 16 11 4 0 0.091 1.00 1.00 471 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), ALDOA(4), ALDOB(2), FUK(2), GMDS(2), HK1(1), HK3(2), KHK(1), MTMR2(1), MTMR6(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(4), PFKP(4), RDH11(2), RDH12(1), RDH14(1), SORD(1), TPI1(2), TSTA3(1) 29216382 37 35 37 11 10 8 6 6 7 0 0.24 1.00 1.00 472 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(3), CARS2(2), DARS(1), DARS2(1), EARS2(3), EPRS(2), FARS2(1), FARSA(1), FARSB(3), GARS(1), IARS(6), IARS2(2), LARS(1), LARS2(2), NARS(1), NARS2(2), PARS2(1), QARS(2), RARS(2), RARS2(2), SARS(2), SARS2(2), TARS(4), TARS2(5), WARS2(1) 39107952 57 53 57 14 11 12 22 7 5 0 0.23 1.00 1.00 473 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4), F12(1), F2(3), F2R(2), F5(11), F8(1), F9(1), FGA(3), FGG(1), KLKB1(1), PROC(1), PROS1(1), SERPINC1(3) 34709727 50 46 50 15 8 12 17 9 4 0 0.42 1.00 1.00 474 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), AKT1(12), AKT2(1), AKT3(3), ARHGAP5(3), BAD(1), BRAF(3), CAPN2(2), CAV1(1), CCND1(1), CCND3(3), COL11A1(2), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), COMP(3), CRKL(1), EGF(2), EGFR(5), ELK1(2), ERBB2(8), FARP2(5), FIGF(2), FLNA(5), FLNB(8), FLNC(9), FLT1(2), FN1(3), GRB2(1), GRLF1(5), HGF(3), IGF1(1), IGF1R(2), ILK(2), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAV(5), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), JUN(1), KDR(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), MAP2K1(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MET(5), MYL7(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PARVA(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP5K1C(4), PPP1R12A(2), PRKCG(2), PTEN(17), PTK2(3), PXN(1), RAF1(1), RAPGEF1(3), RELN(13), RHOA(2), ROCK1(1), ROCK2(2), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), SPP1(2), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TLN1(9), TLN2(5), TNC(5), TNN(5), TNR(2), TNXB(5), VAV1(2), VAV2(1), VAV3(1), VCL(3), VWF(8) 283867779 656 366 479 171 91 160 126 179 98 2 0.0015 1.00 1.00 475 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(5), ACVR1C(1), AKT1(12), AKT2(1), AKT3(3), ARRB1(1), ARRB2(1), ATF2(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(6), CACNA1B(7), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1F(8), CACNA1G(5), CACNA1H(4), CACNA1I(2), CACNA1S(2), CACNA2D1(4), CACNA2D2(4), CACNA2D3(5), CACNA2D4(1), CACNB1(1), CACNB2(2), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(1), CACNG6(1), CACNG8(1), CD14(1), CDC25B(3), CRKL(1), DUSP10(1), DUSP16(3), DUSP4(1), DUSP6(1), DUSP7(1), DUSP9(1), EGF(2), EGFR(5), ELK1(2), FAS(1), FASLG(1), FGF10(1), FGF11(1), FGF13(2), FGF18(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(4), FGFR3(1), FGFR4(3), FLNA(5), FLNB(8), FLNC(9), GRB2(1), IKBKB(3), IL1A(1), IL1R1(1), IL1R2(4), JUN(1), KRAS(4), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(20), MAP2K5(2), MAP2K7(1), MAP3K1(46), MAP3K10(4), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(1), MAP3K8(2), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MAPKAPK3(1), MAPT(1), MAX(2), MEF2C(2), MKNK2(1), MOS(2), MYC(1), NF1(14), NFATC2(1), NFATC4(3), NFKB1(1), NFKB2(3), NLK(1), NR4A1(1), NTRK1(3), NTRK2(3), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PPM1B(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), PTPN5(3), PTPN7(2), PTPRR(2), RAF1(1), RAPGEF2(1), RASA1(2), RASA2(2), RASGRF1(4), RASGRP2(2), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(1), RPS6KA6(3), SOS1(4), SOS2(2), SRF(1), STK3(1), STK4(2), TAOK1(2), TAOK2(1), TAOK3(3), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF1A(1), TP53(187), TRAF6(2), ZAK(1) 225555681 629 344 537 133 114 93 129 107 169 17 0.000017 1.00 1.00 476 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ACTN2(8), ACTN3(1), ACTN4(4), APC(3), ARAF(1), ARHGEF1(5), ARHGEF12(2), ARHGEF4(3), ARHGEF6(1), ARHGEF7(2), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(2), BDKRB1(2), BDKRB2(1), BRAF(3), C3orf10(1), CD14(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CRKL(1), CYFIP1(1), CYFIP2(5), DIAPH2(1), DIAPH3(1), EGF(2), EGFR(5), EZR(2), F2(3), F2R(2), FGD3(3), FGF10(1), FGF11(1), FGF13(2), FGF18(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(4), FGFR3(1), FGFR4(3), FN1(3), GIT1(1), GRLF1(5), GSN(1), IQGAP1(1), IQGAP2(2), IQGAP3(4), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAD(1), ITGAE(1), ITGAL(1), ITGAM(1), ITGAV(5), ITGAX(4), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), KRAS(4), LIMK1(3), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(2), MSN(1), MYH10(7), MYH14(8), MYH9(4), MYL7(1), MYLK(6), MYLK2(1), NCKAP1(3), NCKAP1L(4), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PPP1R12A(2), PTK2(3), PXN(1), RAF1(1), RDX(1), RHOA(2), ROCK1(1), ROCK2(2), SCIN(2), SOS1(4), SOS2(2), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(5), VAV1(2), VAV2(1), VAV3(1), VCL(3), WAS(2), WASF1(3), WASL(1) 215264088 508 320 342 122 63 120 98 164 63 0 0.00052 1.00 1.00 477 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(3), ADCY3(2), ADCY4(2), ADCY7(4), ADCY8(4), ADCY9(5), ADRA1A(2), ADRA1B(1), ATP2A1(2), ATP2A2(1), ATP2A3(1), ATP2B1(4), ATP2B2(2), ATP2B3(6), ATP2B4(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), CACNA1A(6), CACNA1B(7), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1F(8), CACNA1G(5), CACNA1H(4), CACNA1I(2), CACNA1S(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CCKBR(1), CD38(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EDNRB(1), EGFR(5), ERBB2(8), ERBB3(9), ERBB4(6), F2R(2), GNAQ(1), GNAS(5), GRIN1(1), GRIN2A(10), GRIN2C(5), GRIN2D(4), GRM1(3), GRM5(1), GRPR(1), HRH1(1), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), LHCGR(4), LTB4R2(1), MYLK(6), MYLK2(1), NOS1(3), NOS3(2), P2RX2(2), P2RX3(1), P2RX4(2), P2RX5(1), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(1), PDGFRA(3), PDGFRB(2), PHKA1(1), PHKA2(4), PHKB(2), PHKG2(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), PPID(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), PTGER3(3), PTGFR(1), PTK2B(3), RYR1(11), RYR2(24), RYR3(13), SLC25A4(1), SLC8A1(1), SLC8A3(1), SPHK2(2), TACR2(1), TNNC2(1), TRPC1(3), VDAC2(2) 211650192 373 232 370 167 104 53 109 72 34 1 0.98 1.00 1.00 478 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(1), COL11A1(2), COL17A1(5), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), COMP(3), DSC2(4), DSC3(1), DSG1(2), DSG3(4), DSG4(2), FN1(3), GJA1(2), GJA10(1), GJA4(1), GJA5(1), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GJC1(1), INA(1), ITGA6(3), ITGB4(4), KRT1(4), KRT14(2), KRT15(1), KRT17(5), KRT18(1), KRT19(2), KRT2(2), KRT25(2), KRT28(3), KRT3(1), KRT33A(1), KRT34(1), KRT35(1), KRT36(2), KRT37(1), KRT38(3), KRT39(1), KRT4(2), KRT6A(1), KRT6C(1), KRT71(1), KRT72(2), KRT73(1), KRT79(1), KRT81(2), KRT82(2), KRT83(1), KRT84(1), KRT85(1), KRT86(1), KRT9(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), LMNB1(1), NES(3), RELN(13), SPP1(2), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TNC(5), TNN(5), TNR(2), TNXB(5), VIM(1), VWF(8) 188549244 277 202 274 117 61 55 77 38 46 0 0.94 1.00 1.00 479 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADCYAP1R1(1), ADORA1(1), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRA2B(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CALCR(1), CALCRL(2), CCKBR(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CNR1(1), CNR2(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(2), CYSLTR2(1), DRD2(1), DRD3(1), DRD4(1), EDNRA(1), EDNRB(1), F2(3), F2R(2), F2RL2(1), FPR1(1), FSHR(4), GABBR1(1), GABBR2(1), GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), GABRB1(1), GABRB2(2), GABRB3(1), GABRE(1), GABRG1(2), GABRG2(2), GABRG3(2), GABRQ(3), GABRR1(1), GALR1(2), GALR2(1), GH2(2), GHR(2), GHRHR(1), GHSR(1), GIPR(1), GLRA2(1), GLRA3(1), GPR156(2), GPR35(1), GPR50(2), GPR63(1), GPR83(3), GRIA1(6), GRIA2(1), GRIA3(6), GRIA4(3), GRID1(7), GRID2(3), GRIK1(5), GRIK2(8), GRIK3(4), GRIK4(1), GRIK5(3), GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), GRIN3A(4), GRIN3B(2), GRM1(3), GRM2(1), GRM3(7), GRM4(1), GRM5(1), GRM6(1), GRM8(1), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(2), HRH3(2), HRH4(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), LEPR(3), LHB(2), LHCGR(4), LTB4R2(1), MAS1(2), MC2R(1), MC3R(2), MC4R(1), MCHR2(1), NMUR1(1), NMUR2(2), NPBWR2(1), NPFFR2(3), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), P2RX2(2), P2RX3(1), P2RX4(2), P2RX5(1), P2RX7(1), P2RY1(2), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PPYR1(1), PRLR(1), PTGDR(1), PTGER3(3), PTGFR(1), PTH2R(2), RXFP1(3), SSTR2(1), SSTR3(2), SSTR5(1), TAAR1(1), TAAR2(1), TAAR5(3), TAAR6(1), TACR2(1), THRA(1), THRB(1), TSHR(4), TSPO(1), UTS2R(1), VIPR1(1) 165953775 313 199 311 110 81 42 107 54 28 1 0.27 1.00 1.00 480 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), AKT1(12), AKT2(1), AKT3(3), AMOTL1(2), ASH1L(5), CASK(4), CGN(1), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CRB3(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTTN(1), EPB41(1), EPB41L1(4), EPB41L2(2), EPB41L3(3), EXOC3(2), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), IGSF5(3), INADL(5), KRAS(4), LLGL1(1), LLGL2(5), MAGI1(3), MAGI2(7), MAGI3(4), MLLT4(9), MPDZ(6), MYH1(5), MYH10(7), MYH11(7), MYH13(4), MYH14(8), MYH15(5), MYH2(2), MYH3(1), MYH4(6), MYH6(7), MYH7(9), MYH7B(7), MYH8(5), MYH9(4), MYL7(1), PARD3(3), PARD6B(1), PPP2CA(1), PPP2CB(2), PPP2R3A(3), PPP2R4(3), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), PTEN(17), RAB13(1), RHOA(2), SPTAN1(2), SYMPK(5), TJP1(4), TJP3(2), VAPA(1), YES1(2), ZAK(1) 149729268 267 192 254 92 50 45 83 35 52 2 0.84 1.00 1.00 481 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ADRA1A(2), ADRA1B(1), ANXA6(2), ARRB1(1), ARRB2(1), ATP1A4(9), ATP1B1(1), ATP1B3(1), ATP2A2(1), ATP2A3(1), ATP2B1(4), ATP2B2(2), ATP2B3(6), CACNA1A(6), CACNA1B(7), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1S(2), CACNB1(1), CALR(1), CAMK1(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CASQ1(2), CASQ2(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), GJA1(2), GJA4(1), GJA5(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(3), GRK4(3), GRK6(1), ITPR1(8), ITPR2(3), ITPR3(4), KCNB1(2), KCNJ3(1), MIB1(4), NME7(3), PKIG(1), PLCB3(1), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RGS1(1), RGS11(1), RGS14(1), RGS17(2), RGS20(2), RGS3(3), RGS4(4), RGS5(1), RGS7(5), RGS9(4), RYR1(11), RYR2(24), RYR3(13), SLC8A1(1), SLC8A3(1), USP5(4), YWHAB(1) 148069857 257 180 257 116 74 35 73 47 27 1 0.95 1.00 1.00 482 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 CD36(1), COL11A1(2), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), DAG1(1), FN1(3), FNDC1(6), FNDC3A(1), GP6(1), HSPG2(9), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAV(5), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), RELN(13), SDC4(1), SPP1(2), SV2A(1), SV2B(1), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TNC(5), TNN(5), TNR(2), TNXB(5), VWF(8) 171055209 245 178 244 111 53 52 65 39 36 0 0.99 1.00 1.00 483 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(1), ABLIM3(2), ARHGEF12(2), CDK5(1), DCC(7), DPYSL2(2), DPYSL5(2), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(2), EPHA2(2), EPHA3(2), EPHA4(1), EPHA5(6), EPHA6(2), EPHA7(3), EPHA8(1), EPHB1(4), EPHB2(2), EPHB3(2), EPHB4(2), EPHB6(2), FES(2), GNAI1(1), GNAI2(1), ITGB1(2), KRAS(4), L1CAM(2), LIMK1(3), LIMK2(1), LRRC4C(1), MAPK1(1), MAPK3(1), MET(5), NCK1(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NGEF(2), NRP1(5), NTNG1(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(6), PLXNA3(3), PLXNB1(1), PLXNB2(3), PLXNB3(1), PLXNC1(2), PPP3CA(3), PPP3CB(3), PTK2(3), RASA1(2), RGS3(3), RHOA(2), RND1(1), ROBO1(4), ROBO2(4), ROBO3(1), ROCK1(1), ROCK2(2), SEMA3A(2), SEMA3B(1), SEMA3C(2), SEMA3D(2), SEMA3E(1), SEMA3F(1), SEMA4A(2), SEMA4B(1), SEMA4D(1), SEMA4F(5), SEMA4G(3), SEMA5A(8), SEMA5B(3), SEMA6A(1), SEMA6C(1), SEMA6D(2), SEMA7A(1), SLIT1(1), SLIT2(3), SLIT3(2), SRGAP1(8), SRGAP3(1), UNC5B(1), UNC5C(5), UNC5D(9) 150736677 225 171 224 77 47 38 73 30 37 0 0.56 1.00 1.00 484 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(6), CACNA1D(5), CACNA1F(8), CACNA1S(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), EGFR(5), ELK1(2), GNAQ(1), GNAS(5), GNRH2(1), GRB2(1), ITPR1(8), ITPR2(3), ITPR3(4), JUN(1), KRAS(4), LHB(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(20), MAP2K7(1), MAP3K1(46), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MMP14(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLD1(1), PRKACA(1), PRKX(1), PTK2B(3), RAF1(1), SOS1(4), SOS2(2) 99865818 215 165 208 69 37 27 46 32 58 15 0.76 1.00 1.00 485 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(1), ACTA2(1), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ARRB1(1), ARRB2(1), ATF2(2), ATF3(1), ATF4(1), ATF5(2), ATP2A2(1), ATP2A3(1), CALCA(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), CREB3(1), CRHR1(3), ETS2(4), GABPA(1), GJA1(2), GNAQ(1), GNB1(1), GNB3(3), GRK4(3), GRK6(1), IGFBP3(1), IL6(2), ITPR1(8), ITPR2(3), ITPR3(4), JUN(1), MIB1(4), MYLK2(1), NFKB1(1), NOS1(3), NOS3(2), PDE4B(2), PDE4D(6), PKIG(1), PLCB3(1), PLCD1(1), PLCG1(5), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RAMP3(1), RGS1(1), RGS11(1), RGS14(1), RGS17(2), RGS20(2), RGS3(3), RGS4(4), RGS5(1), RGS7(5), RGS9(4), RLN1(1), RYR1(11), RYR2(24), RYR3(13), SLC8A1(1), SP1(2), TNXB(5), USP5(4), YWHAB(1) 132315339 215 163 215 91 60 28 64 36 27 0 0.91 1.00 1.00 486 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 125 ALCAM(2), CADM1(1), CD2(2), CD22(2), CD226(2), CD274(1), CD276(1), CD34(1), CD4(2), CD40(1), CD40LG(1), CD86(2), CD8A(1), CD99(2), CDH1(33), CDH15(2), CDH2(1), CDH4(3), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CNTN1(5), CNTN2(4), CNTNAP1(3), CNTNAP2(3), CTLA4(1), ESAM(2), F11R(1), GLG1(2), HLA-A(6), HLA-C(3), HLA-DMB(2), HLA-DQB1(2), HLA-DRB1(4), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), ICOS(1), ICOSLG(1), ITGA4(1), ITGA6(3), ITGA8(2), ITGA9(2), ITGAL(1), ITGAM(1), ITGAV(5), ITGB1(2), ITGB2(3), ITGB8(2), L1CAM(2), MADCAM1(1), MAG(1), MPZL1(1), NCAM1(4), NCAM2(2), NEO1(4), NFASC(6), NLGN1(1), NLGN2(2), NLGN3(4), NRCAM(2), NRXN1(4), NRXN2(5), NRXN3(7), PDCD1(1), PTPRC(1), PTPRF(5), PTPRM(3), PVRL1(1), PVRL2(3), PVRL3(3), SDC4(1), SELE(1), SELL(4), SELP(5), SELPLG(1), SIGLEC1(1), SPN(2), VCAM1(2), VCAN(10) 108551742 226 162 221 62 36 38 59 32 61 0 0.098 1.00 1.00 487 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(1), ACVR1B(5), ACVR2A(3), AMHR2(2), BMP2(3), BMPR1B(2), BMPR2(2), CCL11(1), CCL13(1), CCL21(1), CCL23(1), CCL7(1), CCR1(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CD40(1), CD40LG(1), CNTFR(1), CSF1(2), CSF2RA(2), CSF2RB(2), CSF3R(2), CX3CL1(1), CX3CR1(2), CXCL6(1), CXCR3(2), EDA(2), EDA2R(1), EDAR(1), EGF(2), EGFR(5), EPOR(2), FAS(1), FASLG(1), FLT1(2), FLT3(3), FLT4(1), GDF5(1), GH2(2), GHR(2), HGF(3), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(2), IL12A(1), IL12B(1), IL12RB1(3), IL13RA1(1), IL15(1), IL17B(2), IL17RA(2), IL17RB(3), IL18R1(1), IL18RAP(3), IL1A(1), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL25(1), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), IL7R(1), INHBA(1), INHBC(1), INHBE(1), KDR(2), KIT(5), KITLG(2), LEPR(3), LIF(3), LIFR(3), LTA(1), MET(5), NGFR(1), OSMR(4), PDGFB(1), PDGFRA(3), PDGFRB(2), PF4(1), PLEKHO2(1), PRLR(1), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF21(2), TNFRSF8(1), TNFSF13B(1), TNFSF14(1), TNFSF18(1), TNFSF4(1), TPO(6), TSLP(1), XCR1(2) 134607993 221 159 219 70 37 46 66 34 38 0 0.20 1.00 1.00 488 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(1), ACTN2(8), ACTN3(1), ACTN4(4), DMD(14), MYBPC1(2), MYBPC2(3), MYBPC3(1), MYH3(1), MYH6(7), MYH7(9), MYH8(5), MYL1(1), MYOM1(3), NEB(19), TMOD1(1), TNNC2(1), TNNI3(1), TNNT1(1), TNNT3(2), TPM1(3), TPM2(1), TPM3(2), TTN(102), VIM(1) 108532983 195 143 195 34 32 22 68 44 28 1 0.0041 1.00 1.00 489 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), ACVR1B(5), ACVR1C(1), BAIAP2(2), CDH1(33), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTNND1(1), EGFR(5), EP300(3), ERBB2(8), FARP2(5), IGF1R(2), INSR(2), IQGAP1(1), LMO7(1), MAP3K7(1), MAPK1(1), MAPK3(1), MET(5), MLLT4(9), NLK(1), PARD3(3), PTPRB(5), PTPRF(5), PTPRJ(1), PTPRM(3), PVRL1(1), PVRL2(3), PVRL3(3), RHOA(2), SMAD2(3), SMAD3(2), SMAD4(1), SNAI1(2), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L2(2), TGFBR1(2), TGFBR2(3), TJP1(4), VCL(3), WAS(2), WASF1(3), WASF3(1), WASL(1), YES1(2) 92210625 183 139 177 54 31 25 48 13 66 0 0.67 1.00 1.00 490 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ADK(1), ADSL(2), AK2(1), AK3L1(1), AK5(2), AK7(2), AMPD1(6), ATIC(3), DGUOK(1), ENPP1(4), ENPP3(2), ENTPD1(2), ENTPD2(2), ENTPD4(2), ENTPD6(1), FHIT(1), GMPR2(1), GMPS(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NME6(1), NME7(3), NPR1(2), NPR2(2), NT5C1B(4), NT5C3(1), NT5E(3), NUDT5(1), PAICS(1), PAPSS1(2), PDE10A(1), PDE11A(3), PDE1A(2), PDE1C(1), PDE2A(3), PDE3B(1), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE5A(1), PDE6G(1), PDE8A(1), PDE9A(3), PFAS(1), PKLR(1), POLA1(4), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(3), POLR3GL(2), PPAT(1), PRPS2(1), PRUNE(3), RRM1(1), RRM2(1), XDH(3) 125975304 174 133 173 66 35 26 59 30 24 0 0.84 1.00 1.00 491 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(2), BRAF(3), CREB1(1), ELK1(2), GRB2(1), IKBKB(3), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(20), MAP2K5(2), MAP2K7(1), MAP3K1(46), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(1), MAP3K8(2), MAP3K9(3), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK4(4), MAPK6(1), MAPK8(2), MAPKAPK3(1), MAX(2), MEF2A(1), MEF2C(2), MKNK2(1), MYC(1), NFKB1(1), NFKBIA(1), PAK1(2), PAK2(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(1), RPS6KB2(4), SHC1(1), SP1(2), STAT1(1), TGFB3(1), TGFBR1(2) 74643075 161 132 158 31 22 19 31 15 59 15 0.12 1.00 1.00 492 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), BAD(1), CABIN1(5), CD3E(1), CD3G(1), CD69(2), CNR1(1), CREBBP(2), CSNK2A1(1), CTLA4(1), EGR2(1), EGR3(3), EP300(3), FCER1A(2), GATA3(56), GRLF1(5), GSK3A(1), ICOS(1), IFNA1(1), IFNB1(1), IL2(1), IL6(2), ITK(4), KPNA5(1), MAP2K7(1), MAPK14(1), MAPK8(2), MEF2A(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB2(3), NFKBIE(1), NUP214(5), OPRD1(2), P2RX7(1), PAK1(2), PPP3CB(3), PTPRC(1), RELA(1), RPL13A(2), SP1(2), SP3(3), TRPV6(2), VAV1(2), VAV2(1), VAV3(1), XPO5(2) 69120831 150 130 127 43 12 20 25 16 75 2 0.96 1.00 1.00 493 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 159 ADORA1(1), ADORA3(2), ADRA1A(2), ADRA1B(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CCKBR(1), CCR1(1), CCR10(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CCRL1(1), CHML(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(1), CX3CR1(2), CXCR3(2), DRD2(1), DRD3(1), DRD4(1), EDNRA(1), EDNRB(1), F2R(2), F2RL2(1), FPR1(1), FSHR(4), GALR1(2), GALR2(1), GALT(1), GHSR(1), GNB2L1(1), GPR17(1), GPR174(2), GPR35(1), GPR37(2), GPR50(2), GPR6(2), GPR63(1), GPR77(2), GPR83(3), GPR85(1), GRPR(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(2), HRH3(2), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), LHCGR(4), MAS1(2), MC3R(2), MC4R(1), NMUR1(1), NMUR2(2), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), OR1F1(1), OR1Q1(2), OR7A5(2), P2RY1(2), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), P2RY6(1), PPYR1(1), PTGDR(1), PTGFR(1), RHO(2), SSTR2(1), SSTR3(2) 88127754 149 122 149 54 40 16 38 36 19 0 0.42 1.00 1.00 494 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(3), C7orf16(1), CACNA1A(6), CRHR1(3), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(5), GRIA1(6), GRIA2(1), GRIA3(6), GRID2(3), GRM1(3), GRM5(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IGF1(1), IGF1R(2), ITPR1(8), ITPR2(3), ITPR3(4), KRAS(4), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(3), NOS3(2), NPR1(2), NPR2(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PPP2CA(1), PPP2CB(2), PRKCG(2), PRKG1(1), PRKG2(6), RAF1(1), RYR1(11) 85565376 146 121 142 43 31 37 42 19 17 0 0.074 1.00 1.00 495 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), DRD2(1), EGF(2), EGFR(5), GJA1(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(5), GRB2(1), GRM1(3), GRM5(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(8), ITPR2(3), ITPR3(4), KRAS(4), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(1), MAPK3(1), NPR1(2), NPR2(2), PDGFB(1), PDGFRA(3), PDGFRB(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(2), PRKG1(1), PRKG2(6), PRKX(1), RAF1(1), SOS1(4), SOS2(2), TJP1(4), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1) 100963980 151 118 149 57 33 28 46 23 21 0 0.72 1.00 1.00 496 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(12), AKT3(3), CAPN1(3), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(1), CAPN6(2), CAV1(1), GRB2(1), ILK(2), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAD(1), ITGAE(1), ITGAL(1), ITGAM(1), ITGAV(5), ITGAX(4), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK10(1), MAPK4(4), MAPK6(1), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PTK2(3), PXN(1), RAPGEF1(3), RHO(2), ROCK1(1), ROCK2(2), SDCCAG8(5), SHC1(1), SHC3(1), SORBS1(4), SOS1(4), TLN1(9), TNS1(4), VAV2(1), VAV3(1), VCL(3) 104524641 145 116 135 54 25 37 31 27 25 0 0.65 1.00 1.00 497 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), AKAP1(2), AKAP11(5), AKAP12(3), AKAP3(2), AKAP4(6), AKAP6(6), AKAP8(1), AKAP9(9), ARHGEF1(5), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(3), ITPR1(8), KCNJ3(1), KRAS(4), PALM2(1), PDE1A(2), PDE1B(2), PDE1C(1), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE8A(1), PLCB3(1), PPP3CA(3), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), PRKD1(2), PRKD3(2), RHOA(2), USP5(4) 89828232 132 113 131 50 27 19 48 24 14 0 0.80 1.00 1.00 498 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADK(1), ADSL(2), AK2(1), AK5(2), AMPD1(6), ATIC(3), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), DGUOK(1), ENPP1(4), ENPP3(2), ENTPD1(2), ENTPD2(2), FHIT(1), GMPS(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(2), NPR2(2), NT5E(3), PAICS(1), PAPSS1(2), PDE1A(2), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE5A(1), PDE6B(2), PDE6C(4), PDE6G(1), PDE8A(1), PDE9A(3), PFAS(1), PKLR(1), POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), PPAT(1), PRPS2(1), PRUNE(3), RRM1(1), RRM2(1) 97752642 143 113 142 54 25 21 51 23 23 0 0.87 1.00 1.00 499 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2A(1), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(1), DDX41(2), DDX50(3), DDX51(1), DDX55(3), DDX56(1), DHX58(2), ENPP1(4), ENPP3(2), ENTPD7(3), EP400(2), ERCC3(2), G6PC2(2), GAA(2), GANC(1), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), IFIH1(1), MGAM(9), MOV10L1(3), NUDT5(1), NUDT8(1), PGM1(2), PGM3(1), PYGB(3), PYGL(1), PYGM(4), RAD54B(4), RAD54L(2), SETX(8), SI(6), SKIV2L2(1), SMARCA2(4), SMARCA5(2), TREH(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2), UXS1(2) 96218460 128 111 128 32 22 19 37 30 20 0 0.12 1.00 1.00 500 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(4), ABCA10(3), ABCA12(5), ABCA13(14), ABCA3(4), ABCA4(6), ABCA5(4), ABCA6(3), ABCA7(5), ABCA8(5), ABCA9(4), ABCB1(3), ABCB10(2), ABCB11(6), ABCB4(1), ABCB5(2), ABCB6(1), ABCB7(2), ABCB8(2), ABCB9(1), ABCC1(3), ABCC10(3), ABCC11(2), ABCC12(5), ABCC2(4), ABCC3(1), ABCC4(4), ABCC5(2), ABCC6(2), ABCC8(7), ABCC9(5), ABCD1(2), ABCD2(2), ABCD3(2), ABCG1(2), ABCG5(2), CFTR(6), TAP1(2) 90399621 133 109 133 39 24 18 54 22 15 0 0.22 1.00 1.00 501 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREB1(1), CREB3(1), CREB3L1(2), CREB3L2(2), CREB3L3(3), CREBBP(2), DCT(1), DVL1(2), DVL3(1), EDN1(2), EDNRB(1), EP300(3), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(5), KIT(5), KITLG(2), KRAS(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7(3), TCF7L2(2), TYR(4), TYRP1(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1) 81496701 131 109 129 59 33 23 42 20 13 0 0.94 1.00 1.00 502 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(3), BDKRB1(2), BDKRB2(1), C1QB(1), C2(1), C3(3), C3AR1(1), C4BPA(1), C4BPB(2), C5(3), C6(4), C7(5), C9(1), CD46(1), CD55(2), CFB(1), CFH(8), CPB2(1), CR1(8), CR2(2), F12(1), F13A1(3), F2(3), F2R(2), F5(11), F7(1), F8(1), F9(1), FGA(3), FGG(1), KLKB1(1), KNG1(3), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(2), PLG(4), PROC(1), PROS1(1), SERPINA1(4), SERPINA5(3), SERPINC1(3), SERPIND1(1), SERPINE1(2), TFPI(1), VWF(8) 68212794 117 102 116 34 13 24 41 22 17 0 0.30 1.00 1.00 503 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(3), ADCY8(4), ARAF(1), ATF4(1), BRAF(3), CACNA1C(6), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREBBP(2), EP300(3), GNAQ(1), GRIA1(6), GRIA2(1), GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), GRM1(3), GRM5(1), ITPR1(8), ITPR2(3), ITPR3(4), KRAS(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PPP1R12A(2), PPP1R1A(2), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3) 78694512 129 102 126 48 29 26 38 18 18 0 0.59 1.00 1.00 504 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(4), CD14(1), CD19(2), CD1A(1), CD1B(3), CD1C(2), CD1D(3), CD1E(3), CD2(2), CD22(2), CD33(1), CD34(1), CD36(1), CD37(1), CD38(2), CD3E(1), CD3G(1), CD4(2), CD5(2), CD55(2), CD8A(1), CD9(2), CR1(8), CR2(2), CSF1(2), CSF2RA(2), CSF3R(2), DNTT(3), EPOR(2), FCGR1A(1), FLT3(3), HLA-DRB1(4), HLA-DRB5(1), IL11RA(2), IL1A(1), IL1R1(1), IL1R2(4), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL7R(1), ITGA1(4), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(5), KITLG(2), TFRC(1), TPO(6) 62238813 116 96 116 33 21 23 33 20 19 0 0.11 1.00 1.00 505 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(1), ACVR1B(5), ACVR1C(1), ACVR2A(3), AMHR2(2), BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BMPR1B(2), BMPR2(2), CHRD(3), COMP(3), CREBBP(2), CUL1(1), E2F4(2), E2F5(1), EP300(3), FST(1), GDF5(1), GDF6(2), ID2(1), INHBA(1), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(5), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(2), RBL1(1), RBL2(1), RHOA(2), ROCK1(1), ROCK2(2), RPS6KB2(4), SMAD2(3), SMAD3(2), SMAD4(1), SMAD9(2), SMURF2(1), SP1(2), TFDP1(1), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(1), THBS3(2), THBS4(1), ZFYVE16(3), ZFYVE9(3) 73937838 107 94 105 34 21 15 25 19 27 0 0.58 1.00 1.00 506 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 90 CD2BP2(1), CLK3(1), CLK4(1), COL2A1(4), CPSF1(3), CPSF3(1), CPSF4(3), CSTF2(1), CSTF2T(2), CSTF3(3), DDX20(2), DHX15(2), DHX38(2), DHX8(1), DICER1(2), FUS(1), GIPC1(1), LOC440563(2), NCBP1(1), NUDT21(1), NXF1(2), PABPN1(1), PAPOLA(1), POLR2A(2), PRPF3(2), PRPF4(2), PRPF4B(3), PRPF8(6), PSKH1(2), PTBP1(2), RBM17(1), RBM5(2), RNGTT(1), SF3B1(10), SF3B2(2), SF3B4(2), SF4(4), SFRS14(1), SFRS16(4), SFRS2(1), SFRS4(2), SFRS5(1), SFRS9(1), SNRPB(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(2), SRRM1(2), SUPT5H(5), TXNL4A(1), XRN2(3) 79639560 108 92 104 22 16 23 29 23 16 1 0.056 1.00 1.00 507 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG1(1), ALG10(1), ALG10B(4), ALG11(1), ALG12(1), ALG13(3), ALG2(2), ALG6(1), ALG8(1), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), C1GALT1(1), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(1), CHST2(3), CHST3(1), DPAGT1(2), EXT1(3), EXT2(2), EXTL3(3), FUT11(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(2), GALNT9(1), GALNTL1(1), GALNTL5(3), GANAB(1), GCNT4(1), HS2ST1(2), HS3ST2(1), HS3ST5(3), HS6ST1(1), HS6ST2(3), HS6ST3(1), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(4), NDST3(1), OGT(2), RPN1(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(3), UST(2), WBSCR17(4), XYLT1(1), XYLT2(1) 81492645 111 91 111 52 18 21 29 21 22 0 0.98 1.00 1.00 508 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(8), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), AKT1(12), AKT2(1), AKT3(3), CAMKK1(3), CAMKK2(2), CD36(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), G6PC2(2), IKBKB(3), IRS1(1), IRS4(4), JAK1(2), JAK2(5), JAK3(2), LEPR(3), MAPK10(1), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(1), PCK2(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(3), PTPN11(1), RELA(1), SLC2A4(1), STAT3(1), TNFRSF1A(1), TYK2(4) 61637511 103 88 92 28 19 23 25 19 16 1 0.16 1.00 1.00 509 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(2), AGPAT3(2), AGPAT6(1), CDS1(2), CDS2(1), CHAT(1), CHKB(1), CHPT1(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), ESCO1(3), ETNK1(3), ETNK2(1), GNPAT(2), GPAM(1), GPD1(2), GPD1L(1), GPD2(1), LCAT(1), MYST3(2), MYST4(6), PCYT1A(1), PCYT1B(3), PHOSPHO1(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLD1(1), PNPLA3(1), PPAP2A(1), PPAP2C(2), PTDSS1(1), PTDSS2(1) 50287302 82 73 79 26 14 16 22 20 10 0 0.40 1.00 1.00 510 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), CARM1(1), DBH(4), DCT(1), DDC(1), ECH1(1), ESCO1(3), FAH(1), GOT2(1), GSTZ1(1), HGD(1), HPD(1), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), MYST3(2), MYST4(6), PNPLA3(1), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), TPO(6), TYR(4), TYRP1(2), WBSCR22(2) 44866458 81 71 81 25 16 15 29 9 12 0 0.42 1.00 1.00 511 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), ENTPD4(2), ENTPD6(1), NME6(1), NME7(3), NT5C1B(4), NT5C3(1), NT5E(3), POLA1(4), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(3), POLR3GL(2), RRM1(1), RRM2(1), TK2(1), UCK2(2), UMPS(2), UPB1(3), UPP1(2), UPRT(1) 62948106 76 67 76 32 12 12 24 16 12 0 0.87 1.00 1.00 512 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 ATP8A1(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CCKBR(1), CCR1(1), CCR10(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CX3CR1(2), CXCR3(2), EDNRA(1), EDNRB(1), FPR1(1), FSHR(4), GALR1(2), GALR2(1), GALT(1), GHSR(1), GNB2L1(1), GPR77(2), GRPR(1), LHCGR(4), MC2R(1), MC3R(2), MC4R(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), PPYR1(1), SSTR2(1), SSTR3(2), TACR2(1), TSHR(4) 38606529 74 67 74 26 15 10 20 20 9 0 0.36 1.00 1.00 513 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(1), ACOX1(2), ACOX3(2), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), APOA5(1), AQP7(3), CD36(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), CYP27A1(1), CYP8B1(1), EHHADH(2), FABP1(1), FABP2(1), FABP4(1), FABP6(1), FADS2(4), GK2(2), HMGCS2(1), ILK(2), LPL(1), PCK1(1), PCK2(1), PLTP(1), PPARA(1), PPARG(1), SCD(1), SLC27A2(1), SLC27A4(4), SLC27A5(2), SORBS1(4), UBC(7), UCP1(1) 48979749 69 64 69 28 10 14 18 13 14 0 0.83 1.00 1.00 514 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BTRC(1), CSNK1A1L(3), CSNK1E(2), CSNK1G3(1), DHH(1), GLI1(2), GLI2(3), GLI3(4), LRP2(18), PRKACA(1), PRKX(1), PTCH1(6), SMO(2), SUFU(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1), ZIC2(1) 44272254 74 64 74 27 26 9 16 16 7 0 0.56 1.00 1.00 515 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(12), BDKRB2(1), CAV1(1), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(1), KDR(2), NOS3(2), PDE2A(3), PDE3A(7), PDE3B(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(6), RYR2(24) 32463210 70 64 60 33 8 21 26 11 4 0 0.87 1.00 1.00 516 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2A(1), ENPP1(4), ENPP3(2), GAA(2), GANAB(1), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), MGAM(9), PGM1(2), PGM3(1), PYGB(3), PYGL(1), PYGM(4), RNPC3(1), SI(6), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2), UXS1(2) 44375175 70 64 70 21 12 9 20 17 12 0 0.45 1.00 1.00 517 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(1), ADCY8(4), CACNA1A(6), CACNA1B(7), GNAS(5), GNAT3(1), GNB1(1), GNB3(3), GRM4(1), ITPR3(4), KCNB1(2), PDE1A(2), PLCB2(2), PRKACA(1), PRKX(1), SCNN1B(1), TAS1R1(1), TAS1R2(2), TAS1R3(1), TAS2R1(1), TAS2R10(1), TAS2R13(1), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R40(1), TAS2R43(4), TAS2R46(1), TAS2R5(1), TAS2R8(1), TAS2R9(2), TRPM5(3) 44161728 69 63 69 34 17 13 13 16 10 0 0.93 1.00 1.00 518 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(1), ACTG2(2), AKT1(12), FLNA(5), FLNC(9), FSCN3(1), GDI1(4), LIMK1(3), MYH2(2), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), WASF1(3), WASL(1) 36197772 63 59 53 22 8 22 17 9 7 0 0.46 1.00 1.00 519 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 59 APC(3), AXIN1(1), CCND1(1), CCND3(3), CSNK1E(2), DVL1(2), DVL3(1), FBXW2(2), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), JUN(1), LDLR(1), MAPK10(1), MYC(1), PAFAH1B1(2), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RHOA(2), SFRP4(1), TCF7(3), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT5B(2), WNT6(1), WNT7A(5) 44264142 64 59 64 25 15 11 16 16 5 1 0.65 1.00 1.00 520 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C1(2), AKR1C2(2), AKR1C3(1), AKR1C4(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), CYP1A2(1), CYP1B1(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP2F1(1), CYP2S1(4), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHDH(1), EPHX1(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTT1(1), GSTZ1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2) 44794971 68 58 68 23 9 15 28 9 7 0 0.44 1.00 1.00 521 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 CREBBP(2), CTBP2(1), DLL1(1), DLL4(1), DTX1(4), DTX2(2), DTX4(1), DVL1(2), DVL3(1), EP300(3), HDAC1(2), HDAC2(3), JAG1(1), JAG2(1), MAML1(1), MAML2(3), MAML3(2), NCOR2(3), NCSTN(2), NOTCH1(2), NOTCH2(7), NOTCH3(3), NUMB(1), NUMBL(4), PSEN1(1), PSEN2(3), PTCRA(1), RBPJL(4), SNW1(2) 50645244 64 56 63 26 13 14 17 8 12 0 0.71 1.00 1.00 522 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(2), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(8), LAT(1), LCP2(1), MAPK1(1), NCK1(1), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PLCG1(5), PTPRC(1), RAF1(1), RASGRP2(2), RASGRP4(1), SOS1(4), SOS2(2), VAV1(2), ZAP70(1) 42438942 61 56 61 17 13 13 13 13 8 1 0.31 1.00 1.00 523 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(1), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CARM1(1), CAT(1), CYP1A2(1), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(4), INMT(2), KMO(1), KYNU(1), LCMT1(1), LCMT2(5), LNX1(2), MAOA(2), MAOB(1), METTL2B(2), OGDH(2), OGDHL(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), TPH2(1), WARS2(1), WBSCR22(2) 46074132 64 55 64 26 8 18 24 6 8 0 0.76 1.00 1.00 524 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(5), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), COX10(3), COX15(1), COX4I2(1), COX5A(1), COX6C(1), COX7B2(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA3(1), NDUFA9(1), NDUFB3(1), NDUFB4(1), NDUFB9(1), NDUFS2(2), NDUFS3(1), NDUFS7(1), NDUFV1(1), NDUFV2(1), PPA1(2), SDHA(1), SDHB(1), TCIRG1(1), UQCRC1(2), UQCRC2(1) 43449393 58 53 58 16 9 7 21 11 10 0 0.38 1.00 1.00 525 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(1), ARSE(2), CARM1(1), CYP11B1(2), CYP11B2(3), HSD11B1(2), HSD17B1(1), HSD17B2(1), HSD3B2(3), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), SRD5A1(1), SRD5A2(3), SULT1E1(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2), WBSCR22(2) 37863267 59 52 59 21 11 11 24 7 6 0 0.62 1.00 1.00 526 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(3), AR(4), ESR1(2), ESR2(2), HNF4A(3), NR1D1(2), NR1D2(1), NR1H2(3), NR1I3(1), NR2C2(1), NR2E1(2), NR4A1(1), NR4A2(1), NR5A2(4), PGR(2), PPARA(1), PPARG(1), RARA(1), RARB(4), RARG(3), ROR1(7), RORC(3), THRA(1), THRB(1) 30889989 54 52 54 20 10 13 10 7 14 0 0.62 1.00 1.00 527 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(12), APC(3), ASAH1(1), DAG1(1), EPHB2(2), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), PITX2(2), PTX3(1), RHO(2), RYR1(11) 35328267 54 52 44 20 7 25 7 8 7 0 0.28 1.00 1.00 528 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(1), AGXT(1), AGXT2(1), ALAS2(3), AMT(2), AOC2(1), AOC3(2), BHMT(1), CBS(2), CHKB(1), CTH(3), DAO(1), DLD(1), DMGDH(4), GARS(1), GATM(4), GCAT(2), MAOA(2), MAOB(1), PIPOX(2), RDH11(2), RDH12(1), RDH14(1), SARDH(2), SARS(2), SARS2(2), TARS(4), TARS2(5) 33053865 55 51 55 21 8 12 12 13 10 0 0.68 1.00 1.00 529 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), CAMK2A(1), CAMK2D(3), CAMK2G(1), CDK5(1), F2(3), GNAI1(1), GNB1(1), GRB2(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(1), MYLK(6), PLCG1(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4), STAT1(1), STAT3(1), STAT5A(3) 32132139 53 50 53 22 8 10 15 9 11 0 0.81 1.00 1.00 530 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN2(8), ACTN3(1), BCR(1), CAPN1(3), CAV1(1), CRKL(1), GRB2(1), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), PTK2(3), PXN(1), RAF1(1), ROCK1(1), SHC1(1), SOS1(4), TLN1(9), VCL(3) 36335169 53 50 53 17 11 9 13 9 11 0 0.52 1.00 1.00 531 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3L1(1), CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), NT5E(3), POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), RRM1(1), RRM2(1), TK2(1), UCK2(2), UMPS(2), UPB1(3), UPP1(2) 43647123 54 50 54 23 5 10 17 10 12 0 0.84 1.00 1.00 532 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CAT(1), CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(3), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), KMO(1), KYNU(1), MAOA(2), MAOB(1), WARS2(1) 41909634 60 50 60 25 7 14 20 12 7 0 0.79 1.00 1.00 533 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AGPAT3(2), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(1), DGAT1(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), GLA(2), GLB1(1), LCT(6), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(4), PNLIPRP2(1), PPAP2A(1), PPAP2C(2) 37096176 55 49 54 19 12 10 17 8 8 0 0.59 1.00 1.00 534 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(1), AGXT(1), AGXT2(1), ALAS2(3), AMT(2), AOC2(1), AOC3(2), BHMT(1), CBS(2), CHKB(1), CPT1B(2), CTH(3), DAO(1), DLD(1), DMGDH(4), GARS(1), GATM(4), GCAT(2), MAOA(2), MAOB(1), PLCB2(2), PLCG1(5), PLCG2(2), SARDH(2), SARS(2), TARS(4) 32456619 53 48 53 20 8 10 13 11 11 0 0.71 1.00 1.00 535 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADSB(3), ACADVL(2), ACAT1(1), ACOX1(2), ACOX3(2), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(4), PECI(1) 37314693 50 48 50 18 7 14 17 8 4 0 0.56 1.00 1.00 536 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(12), AKT2(1), AKT3(3), ANKRD6(4), APC(3), AXIN1(1), CER1(1), DKK2(1), DKK3(1), DKK4(1), DVL1(2), GSK3A(1), LRP1(9), MVP(1), NKD1(1), NKD2(2), PSEN1(1), PTPRA(1), SFRP1(3), WIF1(2) 31142475 51 48 41 17 11 18 8 7 7 0 0.30 1.00 1.00 537 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AASDHPPT(2), AASS(3), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DOT1L(4), ECHS1(1), EHHADH(2), EHMT1(3), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(4), OGDH(2), OGDHL(2), PIPOX(2), PLOD1(1), PLOD2(1), PLOD3(2), RDH11(2), RDH12(1), RDH14(1), SETD7(1), SETDB1(7) 42221439 50 47 49 22 6 13 18 8 5 0 0.83 1.00 1.00 538 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F12(1), F2(3), F5(11), F7(1), F8(1), F9(1), FGA(3), FGG(1), LPA(7), PLAT(2), PLAU(2), PLG(4), SERPINE1(2), VWF(8) 26821821 47 45 46 17 6 7 19 9 6 0 0.64 1.00 1.00 539 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(3), ABAT(3), ACAT1(1), ACSM1(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HADH(1), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(4), ILVBL(2), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(2), PDHA2(2), PDHB(1), PLA1A(2), RDH11(2), RDH12(1), RDH14(1) 31082649 47 45 47 18 3 14 12 14 4 0 0.72 1.00 1.00 540 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(3), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), NFAT5(3), PDE6A(1), PDE6B(2), PDE6C(4), PDE6G(1), SLC6A13(2), TF(1) 27843933 44 44 44 16 4 12 8 11 9 0 0.58 1.00 1.00 541 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(3), CAPN2(2), CXCR3(2), EGF(2), EGFR(5), ITGA1(4), ITGB1(2), MAPK1(1), MAPK3(1), MYLK(6), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTK2(3), PXN(1), TLN1(9) 25719096 45 43 45 17 6 11 14 11 3 0 0.69 1.00 1.00 542 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(1), AGMAT(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), CKMT2(2), CPS1(5), DAO(1), GATM(4), GOT2(1), MAOA(2), MAOB(1), NOS1(3), NOS3(2), OTC(1), P4HA2(1), P4HA3(1), P4HB(1), RARS(2) 33901569 47 42 47 15 7 10 19 8 3 0 0.45 1.00 1.00 543 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA1(1), ACAA2(1), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCAT2(2), BCKDHA(1), DLD(1), ECHS1(1), EHHADH(2), HADH(1), HADHB(1), HIBCH(2), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(4), IVD(1), MCCC1(2), MUT(1), OXCT1(1), OXCT2(1), PCCA(1), PCCB(1) 32908863 43 42 43 15 4 10 14 11 4 0 0.66 1.00 1.00 544 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CREB1(1), ELK1(2), GNAI1(1), GNAQ(1), GNAS(5), GNB1(1), JUN(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KA3(2) 25572573 42 41 42 14 8 9 12 9 4 0 0.53 1.00 1.00 545 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), ABO(4), B3GALNT1(1), B3GALT1(1), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT2(2), FUT3(4), FUT5(1), GBGT1(1), PIGA(1), PIGB(1), PIGG(1), PIGQ(3), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1) 37372491 42 40 41 18 6 12 9 9 6 0 0.68 1.00 1.00 546 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF1B2(1), EEF1D(1), EEF2(2), EEF2K(3), EIF1AX(2), EIF2AK1(1), EIF2AK3(1), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), EIF4A2(5), EIF4G1(1), EIF4G3(2), EIF5(2), EIF5B(2), ETF1(2), GSPT2(2), KIAA0664(1), PABPC1(3), PABPC3(3), SLC35A4(2) 34177377 43 40 43 14 8 7 13 5 10 0 0.59 1.00 1.00 547 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(1), CDK2(1), DIAPH2(1), MCM10(2), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), NACA(3), ORC1L(1), ORC2L(1), ORC3L(1), POLD2(1), POLD4(1), POLE(5), POLE2(1), RFC1(2), RFC4(3), RPA1(1), UBC(7) 38659257 40 39 40 15 5 7 13 8 7 0 0.85 1.00 1.00 548 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP5(3), ARHGAP6(1), ARHGEF1(5), ARHGEF11(2), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(2), GSN(1), LIMK1(3), MYLK(6), OPHN1(2), PIP5K1A(1), ROCK1(1), TLN1(9), VCL(3) 35765301 43 38 43 22 7 6 13 6 11 0 0.97 1.00 1.00 549 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(1), ALG10B(4), ALG11(1), ALG12(1), ALG13(3), ALG2(2), ALG5(1), ALG6(1), ALG8(1), ALG9(1), B4GALT1(2), B4GALT3(1), DPAGT1(2), GANAB(1), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(4), RPN1(2) 31817292 39 36 39 15 3 10 12 7 7 0 0.76 1.00 1.00 550 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(3), ATF2(2), AXIN1(1), BMP10(1), BMP2(3), BMP4(2), BMP5(1), BMPR2(2), CHRD(3), DVL1(2), FZD1(1), MAP3K7(1), MEF2C(2), NPPA(1), RFC1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2) 27194973 36 34 35 19 6 7 8 9 6 0 0.95 1.00 1.00 551 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), CBX3(2), CLDN5(1), CRY1(1), EIF4G2(1), ETV6(2), HSPA8(3), IDI1(2), MYF6(1), NCKAP1(3), NR1D2(1), PER1(3), PER2(3), PPP2CB(2), TOB1(1), TUBB3(1), UCP3(1), VAPA(1), ZFR(5) 27775488 36 34 36 12 3 8 11 8 6 0 0.63 1.00 1.00 552 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC4(1), ANAPC5(5), ANAPC7(2), BTRC(1), CDC23(1), CDC27(1), CUL1(1), CUL3(1), FBXW7(2), ITCH(1), SMURF2(1), UBA1(4), UBE2D2(2), UBE2E1(1), UBE2E3(1), WWP1(1), WWP2(6) 31442619 34 34 34 13 8 11 4 6 5 0 0.72 1.00 1.00 553 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ABP1(1), ACADSB(3), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), MLYCD(2), UPB1(3) 21822801 35 33 35 15 3 10 10 8 4 0 0.78 1.00 1.00 554 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(3), ACACB(8), ACAT1(1), ACSS1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HIBCH(2), LDHC(1), MLYCD(2), MUT(1), PCCA(1), PCCB(1), SUCLA2(1) 30260802 33 32 33 12 3 7 12 9 2 0 0.69 1.00 1.00 555 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLB(1), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLG(1), POLH(2), POLI(3), POLL(1), POLQ(6), REV1(2), REV3L(5) 31857345 34 32 34 12 2 5 12 8 7 0 0.80 1.00 1.00 556 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(8), BAIAP2(2), CASP1(1), CASP8(3), INSR(2), ITCH(1), MAGI1(3), MAGI2(7), RERE(2), WWP1(1), WWP2(6) 17922450 36 32 34 13 8 11 2 7 8 0 0.72 1.00 1.00 557 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(1), ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ATP7A(6), ATP7B(1), COX10(3), COX5A(1), COX6C(1), NDUFA1(1), NDUFA10(1), NDUFB4(1), NDUFS2(2), NDUFV1(1), NDUFV2(1), SDHA(1), SDHB(1), UQCRC1(2) 29686878 35 32 35 13 8 6 8 6 7 0 0.70 1.00 1.00 558 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(1), CBS(2), CTH(3), GGT1(2), LCMT1(1), LCMT2(5), MAT1A(1), MAT2B(1), METTL2B(2), PAPSS1(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), SEPHS1(1), SEPHS2(1), WBSCR22(2) 18848232 36 31 36 13 10 9 9 0 8 0 0.42 1.00 1.00 559 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(3), COX10(3), COX15(1), CP(2), EARS2(3), EPRS(2), GUSB(1), HMBS(1), PPOX(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2) 32345586 33 31 33 15 6 3 14 6 4 0 0.93 1.00 1.00 560 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(1), ARRB2(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CLCA1(1), CLCA2(1), CNGA3(3), CNGA4(2), CNGB1(2), GUCA1A(2), GUCA1C(1), PDE1C(1), PRKACA(1), PRKG1(1), PRKG2(6), PRKX(1) 23608962 31 31 31 19 6 8 7 7 3 0 0.96 1.00 1.00 561 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADSB(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCKDHA(1), ECHS1(1), EHHADH(2), HADHB(1), IVD(1), MCCC1(2), MUT(1), OXCT1(1), PCCA(1), PCCB(1) 27494610 32 31 32 14 2 7 12 8 3 0 0.86 1.00 1.00 562 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), C1GALT1C1(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(2), GALNT9(1), GALNTL1(1), GALNTL5(3), GCNT4(1), OGT(2), ST3GAL1(1), ST6GALNAC1(3), WBSCR17(4) 24775569 35 30 35 14 6 4 10 4 11 0 0.79 1.00 1.00 563 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), L2HGDH(1), OXCT1(1), PDHA1(2), PDHA2(2), PDHB(1), SDHB(1) 19613295 30 29 30 13 2 9 10 9 0 0 0.78 1.00 1.00 564 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ABP1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HIBCH(2), MLYCD(2), UPB1(3) 20191275 31 29 31 13 3 7 9 8 4 0 0.78 1.00 1.00 565 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 30 AASDH(1), AASDHPPT(2), AASS(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DOT1L(4), ECHS1(1), EHHADH(2), EHMT1(3), GCDH(1), PLOD1(1), PLOD2(1), PLOD3(2) 26160186 30 29 30 17 3 7 11 5 4 0 0.96 1.00 1.00 566 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CYP2C19(1), CYP2C9(2), DHRS2(3), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(1) 23359011 29 28 29 13 3 7 10 7 2 0 0.83 1.00 1.00 567 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), DRD2(1), DRD3(1), DRD4(1), HRH1(1), HRH2(2), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4) 19319742 29 28 29 13 12 0 9 3 5 0 0.75 1.00 1.00 568 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CDK7(2), ERCC3(2), GTF2E2(1), GTF2F2(1), GTF2H1(1), ILK(2), MNAT1(1), POLR1A(2), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3B(3), POLR3E(2), TAF6(1), TAF7(1), TBP(1) 26354874 30 28 30 14 6 7 7 4 6 0 0.74 1.00 1.00 569 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(3), ACADSB(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), LDHC(1), MLYCD(2), MUT(1), PCCA(1), PCCB(1), SUCLA2(1) 25275471 28 27 28 14 1 10 8 7 2 0 0.91 1.00 1.00 570 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(2), EGFR(5), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SPRY3(1) 19124547 26 25 26 13 4 5 6 6 5 0 0.95 1.00 1.00 571 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), EPHB2(2), F2(3), F2RL2(1), JUN(1), MAP2K5(2), MAPK1(1), MAPK8(2), MYEF2(2), PLD1(1), PLD3(2), PTK2(3), RAF1(1), RASAL1(2), TEC(1), VAV1(2) 21122127 29 25 29 10 5 7 9 3 5 0 0.55 1.00 1.00 572 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(3), CD3E(1), CD3G(1), CD4(2), CREBBP(2), GNAS(5), GNB1(1), HLA-DRB1(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1) 16692468 24 24 24 10 4 5 5 7 3 0 0.74 1.00 1.00 573 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(3), EDN1(2), EDNRA(1), EDNRB(1), EGF(2), EGFR(5), JUN(1), MYC(1), NFKB1(1), PLCG1(5), RELA(1) 15534987 24 24 24 10 3 4 6 7 4 0 0.82 1.00 1.00 574 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(3), CD3E(1), CD3G(1), CD4(2), CREBBP(2), GNAS(5), GNB1(1), HLA-DRB1(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1) 16692468 24 24 24 10 4 5 5 7 3 0 0.74 1.00 1.00 575 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), AOC2(1), AOC3(2), ASPA(2), CNDP1(2), DDC(1), HAL(2), MAOA(2), MAOB(1), PRPS2(1) 18594732 28 24 28 10 2 6 13 3 4 0 0.59 1.00 1.00 576 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(1), AOC2(1), AOC3(2), CES1(2), CES7(1), ESCO1(3), LIPA(1), MYST3(2), MYST4(6), PLA1A(2), PNPLA3(1) 19039371 25 24 25 11 4 8 5 4 4 0 0.77 1.00 1.00 577 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4), P4HB(1), SLC23A1(2), SLC2A3(2) 20107620 26 24 26 12 6 5 7 6 2 0 0.75 1.00 1.00 578 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(3), COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4) 20047794 25 23 25 12 5 5 6 6 3 0 0.81 1.00 1.00 579 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(2), ACYP1(1), DHRS2(3), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), GCDH(1), ITGB1BP3(1), MYST3(2), MYST4(6), PNPLA3(1) 19635603 25 23 25 12 5 5 6 7 2 0 0.83 1.00 1.00 580 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(1), GOSR1(1), SNAP23(2), SNAP25(1), STX10(1), STX11(1), STX12(1), STX16(1), STX17(1), STX19(2), STX3(1), STX6(1), STX7(1), TSNARE1(4), USE1(1), VAMP1(1), VAMP3(1), VAMP7(1) 12881856 23 23 23 11 4 3 7 2 7 0 0.90 1.00 1.00 581 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(4), CETP(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(9), SCARB1(2), SOAT1(1) 20771790 23 23 23 11 5 6 8 1 3 0 0.83 1.00 1.00 582 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(3), BCAT2(2), IARS(6), IARS2(2), ILVBL(2), LARS(1), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1) 11908923 23 21 23 10 6 5 6 4 2 0 0.79 1.00 1.00 583 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(3), POLR3GL(2) 17691258 22 21 22 12 4 4 6 4 4 0 0.89 1.00 1.00 584 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CAPN2(2), EP300(3), HDAC1(2), HDAC2(3), NFATC1(1), NFATC2(1), PPP3CA(3), PPP3CB(3) 17986332 23 21 22 13 1 8 4 4 6 0 0.92 1.00 1.00 585 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(3), AXIN1(1), CREBBP(2), DVL1(2), EP300(3), FZD1(1), HDAC1(2), LDB1(1), PITX2(2), TRRAP(5) 24986988 22 21 21 11 2 3 5 7 5 0 0.92 1.00 1.00 586 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(8), ACTN3(1), CTNNA1(2), CTNNA2(4), PTK2(3), PXN(1), VCL(3) 14958528 22 20 22 12 6 4 6 2 4 0 0.92 1.00 1.00 587 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(2), AMT(2), ATIC(3), FTCD(1), MTHFD1(4), MTHFD1L(3), MTHFS(1), MTR(5) 14530620 21 20 21 10 1 6 6 3 5 0 0.88 1.00 1.00 588 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), HDAC5(2), MEF2A(1), MEF2C(2), PPARA(1), PPP3CA(3), PPP3CB(3), SLC2A4(1) 16291938 21 20 21 11 1 6 4 6 4 0 0.90 1.00 1.00 589 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(2), AMT(2), ATIC(3), MTHFD1(4), MTHFD1L(3), MTHFS(1), MTR(5) 13721448 20 19 20 10 1 6 6 2 5 0 0.90 1.00 1.00 590 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(3), AXIN1(1), BTRC(1), CCND1(1), CREBBP(2), CSNK2A1(1), DVL1(2), FZD1(1), HDAC1(2), MAP3K7(1), MYC(1), NLK(1), PPP2CA(1), WIF1(2) 22554402 20 19 20 12 2 6 5 4 3 0 0.96 1.00 1.00 591 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2) 20869134 19 18 19 10 3 1 8 5 2 0 0.91 1.00 1.00 592 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(1), CHST3(1), DSE(7), UST(2), XYLT1(1), XYLT2(1) 9360741 17 17 17 10 6 5 4 1 1 0 0.87 1.00 1.00 593 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGT(3), ANPEP(4), CTSA(1), CTSG(1), ENPEP(2), MAS1(2), THOP1(1) 16157076 17 17 17 11 2 3 5 4 3 0 0.97 1.00 1.00 594 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR24(1), EBP(1), FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), LSS(2), NQO1(1), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1), VKORC1(1) 14746095 16 16 16 11 4 2 6 2 2 0 0.98 1.00 1.00 595 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADVL(2), ACSL3(1), ACSL4(2), CPT1A(3), CPT2(3), EHHADH(2), SLC25A20(1) 12761697 14 14 14 8 2 6 5 1 0 0 0.88 1.00 1.00 596 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB11(6), ABCB4(1), ABCC1(3), ABCC3(1) 11177322 14 14 14 12 2 2 6 2 2 0 0.99 1.00 1.00 597 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(3), AXIN1(1), BTRC(1), DLL1(1), DVL1(2), FZD1(1), NOTCH1(2), PSEN1(1) 16001934 12 12 12 10 1 3 2 5 1 0 0.99 1.00 1.00 598 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), PRKCE(1), SOD1(1) 6005415 11 11 11 5 2 2 4 3 0 0 0.75 1.00 1.00 599 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2) 9291789 11 11 11 9 0 3 6 2 0 0 0.98 1.00 1.00 600 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 6035328 8 8 8 5 0 3 5 0 0 0 0.91 1.00 1.00 601 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 6035328 8 8 8 5 0 3 5 0 0 0 0.91 1.00 1.00 602 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR109B(1), GPR161(2), GPR34(1), GPR75(1) 7546695 8 8 8 9 0 1 2 5 0 0 1.00 1.00 1.00 603 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ACYP1(1), ECHS1(1), EHHADH(2), GCDH(1), SDHB(1) 6033300 7 7 7 6 1 1 2 3 0 0 0.96 1.00 1.00 604 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(1), ATF3(1), CYR61(1), IFRD1(1), IL1A(1), IL1R1(1), NR4A3(1) 8218470 7 7 7 5 2 1 3 1 0 0 0.92 1.00 1.00 605 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(1), NR0B2(2), NR1H4(1) 4032171 5 5 5 4 1 0 3 1 0 0 0.96 1.00 1.00 606 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), HMGCS1(1), HMGCS2(1), OXCT1(1), OXCT2(1) 5437575 5 5 5 4 0 1 2 2 0 0 0.96 1.00 1.00 607 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(1), DNMT1(1), PTGDR(1), PTGFR(1) 8131266 5 5 5 6 1 0 1 3 0 0 1.00 1.00 1.00 608 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(1), SNAP25(1) 2471625 4 4 4 3 0 0 4 0 0 0 0.92 1.00 1.00 609 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), XYLT1(1), XYLT2(1) 4663386 4 4 4 5 3 0 0 1 0 0 0.98 1.00 1.00 610 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), XYLT1(1), XYLT2(1) 4663386 4 4 4 5 3 0 0 1 0 0 0.98 1.00 1.00 611 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(3), MMP9(1) 5851794 4 4 3 5 1 3 0 0 0 0 0.95 1.00 1.00 612 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(2) 3768531 3 3 3 4 0 0 1 2 0 0 0.98 1.00 1.00 613 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(2) 1529619 3 3 3 2 0 1 2 0 0 0 0.93 1.00 1.00 614 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACAT1(1), ECHS1(1) 4084392 2 2 2 4 0 1 0 1 0 0 0.99 1.00 1.00 615 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), OXCT1(1) 2570490 2 2 2 2 0 1 1 0 0 0 0.96 1.00 1.00 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 384306 0 0 0 0 0 0 0 0 0 0 1.00 1.00 1.00