rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	123	ALCAM(2), CADM1(8), CADM3(8), CD2(3), CD22(10), CD226(4), CD274(4), CD28(2), CD34(1), CD4(2), CD40(1), CD40LG(6), CD58(2), CD6(3), CD80(1), CD8B(2), CDH1(5), CDH15(1), CDH3(4), CDH4(11), CDH5(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CNTN2(7), CNTNAP1(7), CNTNAP2(12), CTLA4(2), ESAM(3), F11R(1), GLG1(4), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(2), ICAM2(1), ICOS(1), ITGA4(8), ITGA6(4), ITGA8(8), ITGA9(6), ITGAL(8), ITGAM(8), ITGAV(5), ITGB1(6), ITGB2(5), ITGB7(4), ITGB8(5), JAM3(3), L1CAM(4), MAG(7), MPZL1(1), NCAM1(6), NEGR1(4), NEO1(6), NFASC(17), NLGN1(7), NLGN2(2), NLGN3(4), NRCAM(7), NRXN2(6), OCLN(1), PDCD1LG2(1), PECAM1(2), PTPRC(17), PTPRF(9), PVR(1), PVRL1(6), PVRL2(4), PVRL3(2), SDC1(1), SDC2(3), SDC3(3), SDC4(1), SELE(4), SELL(3), SELP(6), SELPLG(2), SIGLEC1(4), SPN(2), VCAM1(9), VCAN(36)	44797856	444	107	434	172	153	150	79	3	55	4	1.45e-08	4.85e-06
2	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	239	ACVR1(4), ACVR2B(4), AMHR2(2), BMP2(1), BMP7(6), BMPR1A(4), BMPR1B(10), BMPR2(10), CCL13(1), CCL15(1), CCL18(2), CCL22(1), CCL23(2), CCL27(3), CCL7(1), CCL8(1), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CCR9(6), CD27(3), CD40(1), CD40LG(6), CD70(5), CNTF(2), CNTFR(2), CSF1(2), CSF1R(3), CSF2RB(7), CSF3R(10), CX3CL1(1), CX3CR1(2), CXCL10(1), CXCL11(3), CXCL12(1), CXCL14(2), CXCL16(1), CXCL5(2), CXCL6(1), CXCL9(3), CXCR4(4), EDA(2), EDA2R(2), EDAR(3), EGF(3), EGFR(11), FAS(2), FASLG(1), FLT1(12), FLT3(5), FLT3LG(1), FLT4(5), GDF5(2), GH1(2), GH2(3), GHR(6), HGF(8), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), IFNK(1), IL10(2), IL10RA(2), IL10RB(5), IL11(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL13(1), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17RA(6), IL17RB(1), IL18RAP(4), IL19(1), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), IL1RAP(1), IL2(4), IL20(3), IL20RA(5), IL21(2), IL21R(5), IL22(2), IL22RA1(1), IL23R(3), IL24(2), IL25(1), IL26(3), IL28RA(3), IL2RA(2), IL2RB(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL6ST(3), IL7(2), IL7R(3), IL8(1), IL9(2), INHBB(1), INHBC(3), INHBE(1), KDR(10), KIT(8), KITLG(2), LEP(1), LEPR(9), LTB(1), LTBR(3), MET(5), MPL(2), NGFR(3), OSM(1), OSMR(6), PDGFC(3), PDGFRA(17), PDGFRB(6), PLEKHO2(5), PRL(3), PRLR(4), RELT(2), TGFB1(1), TGFB2(9), TGFBR1(9), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(4), TNFRSF13B(4), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(1), TNFRSF21(5), TNFRSF4(1), TNFRSF8(2), TNFRSF9(3), TNFSF10(1), TNFSF11(1), TNFSF12(2), TNFSF13B(1), TNFSF14(3), TNFSF15(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(11), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(6), XCL2(1), XCR1(1)	55738392	559	117	550	193	181	206	101	0	70	1	1.85e-08	4.85e-06
3	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	119	ABL1(4), ABLIM1(6), ABLIM2(4), ABLIM3(5), ARHGEF12(9), CDC42(1), CFL1(1), CXCL12(1), CXCR4(4), DPYSL2(5), DPYSL5(1), EFNA3(1), EFNA4(1), EFNA5(5), EFNB1(3), EFNB2(1), EFNB3(3), EPHA1(6), EPHA2(5), EPHA4(6), EPHA6(5), EPHA7(10), EPHA8(7), EPHB1(9), EPHB2(8), EPHB3(2), EPHB4(5), EPHB6(4), FYN(5), GNAI1(4), ITGB1(6), L1CAM(4), LIMK1(5), LIMK2(5), LRRC4C(8), MAPK1(2), MAPK3(3), MET(5), NCK1(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NGEF(1), NRP1(1), NTN1(5), NTN4(6), NTNG1(4), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PLXNA1(2), PLXNA2(8), PLXNA3(2), PLXNB1(5), PLXNB2(2), PLXNB3(3), PLXNC1(9), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PTK2(5), RASA1(9), RGS3(10), RHOA(5), RND1(1), ROBO3(5), ROCK1(15), ROCK2(6), SEMA3A(9), SEMA3B(1), SEMA3C(3), SEMA3D(13), SEMA3E(9), SEMA3F(1), SEMA3G(4), SEMA4A(3), SEMA4B(2), SEMA4D(13), SEMA4F(9), SEMA4G(6), SEMA5A(8), SEMA5B(11), SEMA6A(2), SEMA6B(2), SEMA6C(3), SEMA6D(9), SEMA7A(2), SLIT1(11), SLIT2(15), SLIT3(9), SRGAP1(9), SRGAP2(3), SRGAP3(4), UNC5A(2), UNC5B(6), UNC5C(12), UNC5D(9)	61310764	521	120	511	166	221	145	80	6	69	0	2.36e-08	4.85e-06
4	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	180	ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), AKT1(2), AKT2(6), AKT3(1), ARHGAP5(9), BAD(1), BCL2(1), BIRC2(4), BIRC3(7), CAPN2(6), CAV1(1), CAV2(1), CAV3(3), CCND2(1), CCND3(1), CDC42(1), CHAD(7), COL11A2(11), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A6(20), COMP(2), CRKL(2), DIAPH1(1), DOCK1(7), EGF(3), EGFR(11), FARP2(5), FIGF(2), FLNA(3), FLNB(16), FLNC(13), FLT1(12), FN1(21), FYN(5), GRB2(3), GRLF1(12), HGF(8), IBSP(3), IGF1(2), IGF1R(8), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAV(5), ITGB1(6), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), KDR(10), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), MAP2K1(4), MAPK1(2), MAPK3(3), MAPK8(7), MAPK9(5), MET(5), MYL2(1), MYL7(1), MYL9(2), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PARVA(1), PARVB(5), PARVG(3), PDGFA(1), PDGFC(3), PDGFD(3), PDGFRA(17), PDGFRB(6), PDPK1(1), PGF(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP5K1C(4), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PRKCA(4), PRKCG(10), PTK2(5), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF1(6), RHOA(5), ROCK1(15), ROCK2(6), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SPP1(1), SRC(3), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TLN1(7), TLN2(8), TNC(16), TNN(17), TNXB(17), VASP(3), VAV1(13), VAV2(4), VAV3(12), VCL(2), VEGFA(2), VEGFB(2), VEGFC(6), VTN(6), VWF(15), ZYX(1)	114292372	1039	158	1026	402	373	349	180	11	124	2	2.60e-07	0.000040
5	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	223	ADCYAP1R1(2), ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(5), ADRA2A(3), ADRA2B(1), ADRB1(3), ADRB3(1), AGTR1(5), AGTR2(5), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), C5AR1(3), CALCR(5), CALCRL(6), CCKAR(2), CCKBR(5), CGA(2), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(5), CRHR1(2), CRHR2(5), CTSG(3), CYSLTR1(3), CYSLTR2(4), DRD1(1), DRD2(5), DRD3(3), DRD5(6), EDNRA(4), F2(3), F2RL1(1), F2RL2(3), FPR1(2), FSHB(2), FSHR(7), GABBR1(6), GABBR2(7), GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA6(5), GABRB1(7), GABRB2(7), GABRB3(9), GABRE(5), GABRG2(11), GABRG3(5), GABRP(4), GABRQ(8), GABRR1(2), GABRR2(4), GALR1(2), GH1(2), GH2(3), GHR(6), GHRHR(2), GHSR(5), GLP1R(7), GLP2R(5), GLRA1(2), GLRA2(3), GLRA3(8), GLRB(7), GNRHR(4), GPR156(8), GPR50(5), GPR63(4), GPR83(1), GRIA2(13), GRIA3(8), GRID2(12), GRIK1(5), GRIK2(14), GRIK4(12), GRIK5(6), GRIN1(1), GRIN2B(10), GRIN2C(4), GRIN2D(5), GRIN3A(6), GRM1(12), GRM2(4), GRM3(7), GRM4(7), GRM5(11), GRM6(10), GRM8(9), GRPR(3), GZMA(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HRH4(2), HTR1A(5), HTR1B(5), HTR1D(2), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), LEP(1), LEPR(9), LHB(1), LHCGR(4), LTB4R(1), MAS1(2), MC2R(5), MC3R(1), MC4R(4), MC5R(6), MCHR1(6), MCHR2(3), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(9), NPBWR1(3), NPFFR2(4), NPY1R(4), NPY2R(5), NPY5R(2), NR3C1(4), NTSR1(1), OPRD1(1), OPRK1(5), OPRM1(3), OXTR(3), P2RX1(1), P2RX2(2), P2RX3(2), P2RX4(3), P2RX5(1), P2RX7(3), P2RY1(6), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(6), P2RY6(1), PARD3(7), PPYR1(4), PRL(3), PRLR(4), PRSS1(3), PRSS2(1), PRSS3(4), PTAFR(1), PTGDR(1), PTGER2(1), PTGER3(7), PTGFR(7), PTGIR(1), PTH2R(7), RXFP1(3), RXFP2(10), SCTR(3), SSTR1(5), SSTR2(3), SSTR4(4), TAAR1(4), TAAR2(2), TAAR5(6), TAAR6(5), TAAR8(2), TAAR9(3), TACR1(2), TACR2(1), TACR3(7), THRA(2), THRB(4), TRHR(8), TRPV1(4), TSHB(1), TSHR(7), VIPR1(4), VIPR2(3)	68090504	831	146	822	318	316	276	162	9	68	0	3.47e-07	0.000043
6	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	156	ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRA2A(3), ADRB1(3), ADRB3(1), AGTR1(5), AGTR2(5), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), CCKAR(2), CCKBR(5), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CCR9(6), CCRL1(5), CHML(5), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), CMKLR1(2), CNR1(5), CX3CR1(2), CXCR4(4), DRD1(1), DRD2(5), DRD3(3), DRD5(6), EDNRA(4), F2RL1(1), F2RL2(3), FPR1(2), FSHR(7), GALR1(2), GALT(2), GHSR(5), GPR17(1), GPR173(2), GPR174(3), GPR37(7), GPR37L1(3), GPR4(1), GPR50(5), GPR6(6), GPR63(4), GPR77(2), GPR83(1), GPR85(1), GPR87(5), GRPR(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HTR1A(5), HTR1B(5), HTR1D(2), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), LHCGR(4), LTB4R(1), MAS1(2), MC3R(1), MC4R(4), MC5R(6), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(9), NPY1R(4), NPY2R(5), NPY5R(2), NTSR1(1), OPN1SW(3), OPN3(1), OPRD1(1), OPRK1(5), OPRM1(3), OR12D3(4), OR1C1(3), OR1F1(2), OR2H1(4), OR5V1(3), OR7A5(3), OR8B8(3), OXTR(3), P2RY1(6), P2RY12(4), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(1), PPYR1(4), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1), RGR(3), RHO(3), RRH(4), SSTR1(5), SSTR2(3), SSTR4(4), SUCNR1(2), TRHR(8)	38211344	424	117	424	149	168	148	75	3	30	0	7.68e-06	0.00078
7	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	160	ADCY1(8), ADCY3(2), ADCY4(9), ADCY7(4), ADCY8(12), ADCY9(6), ADORA2A(5), ADORA2B(1), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRB1(3), ADRB3(1), AGTR1(5), ATP2A1(6), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(4), ATP2B4(8), AVPR1A(4), AVPR1B(3), BDKRB2(3), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1F(14), CACNA1G(10), CACNA1H(2), CACNA1I(5), CACNA1S(14), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CCKAR(2), CCKBR(5), CD38(2), CHRM1(3), CHRM3(4), CHRM5(2), CHRNA7(1), CYSLTR1(3), CYSLTR2(4), DRD1(1), EDNRA(4), EGFR(11), GNA11(1), GNA14(6), GNA15(3), GNAL(4), GNAQ(4), GNAS(6), GRIN1(1), GRIN2C(4), GRIN2D(5), GRM1(12), GRM5(11), GRPR(3), HRH1(1), HRH2(4), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), LHCGR(4), MYLK(14), MYLK2(3), NOS1(11), NOS3(2), NTSR1(1), OXTR(3), P2RX1(1), P2RX2(2), P2RX3(2), P2RX4(3), P2RX5(1), P2RX7(3), PDE1A(4), PDE1B(3), PDE1C(9), PDGFRA(17), PDGFRB(6), PHKA1(8), PHKA2(6), PHKB(6), PHKG2(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PLN(1), PPID(3), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PTAFR(1), PTGER3(7), PTGFR(7), PTK2B(1), RYR1(25), RYR2(59), RYR3(42), SLC25A4(1), SLC25A5(1), SLC8A1(13), SLC8A2(4), SLC8A3(7), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(7), TNNC2(1), TRHR(8), TRPC1(6), VDAC1(1), VDAC3(1)	87738276	852	158	843	333	361	260	148	5	75	3	9.83e-06	0.00078
8	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	82	AGRN(1), CD36(1), CD44(3), CD47(3), CHAD(7), COL11A2(11), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A6(20), DAG1(5), FN1(21), FNDC1(23), FNDC3A(7), FNDC4(1), GP1BA(1), GP5(6), GP6(2), HMMR(6), HSPG2(9), IBSP(3), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAV(5), ITGB1(6), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), SDC1(1), SDC2(3), SDC3(3), SDC4(1), SPP1(1), SV2A(5), SV2B(6), SV2C(4), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TNC(16), TNN(17), TNXB(17), VTN(6), VWF(15)	69408448	641	131	635	270	225	226	104	9	76	1	0.000011	0.00078
9	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	82	ACVR1(4), ACVR1C(3), ACVR2B(4), ACVRL1(4), AMHR2(2), BMP2(1), BMP4(2), BMP5(5), BMP6(3), BMP7(6), BMP8A(1), BMPR1A(4), BMPR1B(10), BMPR2(10), CHRD(5), COMP(2), CREBBP(25), CUL1(8), DCN(4), E2F4(1), E2F5(2), EP300(15), FST(3), GDF5(2), GDF6(3), IFNG(1), INHBB(1), INHBC(3), INHBE(1), LTBP1(9), MAPK1(2), MAPK3(3), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2C(4), RBL1(5), RBL2(8), RBX1(1), RHOA(5), ROCK1(15), ROCK2(6), RPS6KB1(3), RPS6KB2(2), SKP1(1), SMAD1(2), SMAD3(9), SMAD5(1), SMAD9(3), SMURF1(3), SMURF2(2), SP1(2), TFDP1(4), TGFB1(1), TGFB2(9), TGFBR1(9), THBS1(10), THBS2(15), THBS3(3), THBS4(2), ZFYVE16(12), ZFYVE9(10)	31056032	309	89	305	103	106	99	59	1	44	0	0.000011	0.00078
10	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRB1(3), ADRB3(1), ANXA6(3), ARRB1(1), ATP1A4(8), ATP1B1(1), ATP1B2(2), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(4), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1S(14), CACNB1(1), CACNB3(2), CALR(1), CAMK1(3), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CASQ1(2), CASQ2(4), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), GJA1(7), GJA4(2), GJA5(3), GJB1(3), GJB3(4), GJB4(1), GNA11(1), GNAO1(5), GNAQ(4), GNAZ(1), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), GRK4(5), GRK5(4), GRK6(3), ITPR1(19), ITPR2(18), ITPR3(12), KCNB1(5), KCNJ3(6), KCNJ5(4), MIB1(3), MYCBP(1), NME7(5), PEA15(1), PKIA(1), PKIB(1), PLCB3(4), PLN(1), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), RGS1(1), RGS10(1), RGS16(2), RGS17(2), RGS18(2), RGS2(3), RGS20(4), RGS3(10), RGS4(3), RGS5(1), RGS6(3), RGS7(6), RGS9(7), RYR1(25), RYR2(59), RYR3(42), SLC8A1(13), SLC8A3(7), USP5(4), YWHAB(2), YWHAH(1), YWHAQ(1)	63124152	613	138	609	253	272	189	98	0	52	2	0.000023	0.0014
11	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(4), ALG1(1), ALG10(3), ALG10B(7), ALG11(1), ALG12(2), ALG13(1), ALG14(1), ALG2(3), ALG3(1), ALG6(3), ALG8(6), ALG9(2), B3GNT1(2), B3GNT2(2), B3GNT7(6), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), C1GALT1C1(2), CHPF(3), CHST1(7), CHST11(3), CHST12(3), CHST13(2), CHST14(1), CHST2(1), CHST4(7), CHSY1(5), DAD1(2), DDOST(2), DPAGT1(2), EXT1(11), EXTL1(3), EXTL2(6), EXTL3(9), FUT11(1), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(2), GALNT13(5), GALNT14(10), GALNT2(4), GALNT3(4), GALNT5(10), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GALNTL1(5), GALNTL2(8), GALNTL4(2), GALNTL5(8), GANAB(4), GCNT1(5), GCNT3(4), GCNT4(7), HS2ST1(4), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), MAN1A1(5), MAN1A2(2), MAN1B1(2), MAN1C1(7), MAN2A1(12), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(4), NDST2(5), NDST3(10), NDST4(4), OGT(5), RPN2(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(3), STT3B(6), UST(1), XYLT1(6), XYLT2(2)	36725808	349	97	345	108	129	107	75	3	35	0	0.000025	0.0014
12	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	133	ACTB(2), CHAD(7), COL11A2(11), COL17A1(8), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A6(20), COMP(2), DES(1), DSC1(8), DSC2(2), DSC3(4), DSG1(8), DSG2(5), DSG3(8), DSG4(9), FN1(21), GJA1(7), GJA10(9), GJA4(2), GJA5(3), GJA8(5), GJA9(4), GJB1(3), GJB3(4), GJB4(1), GJB7(2), GJC1(4), GJC2(1), GJC3(2), GJD2(1), GJD4(2), IBSP(3), INA(2), ITGA6(4), ITGB4(3), KRT1(4), KRT10(2), KRT12(2), KRT13(4), KRT14(2), KRT15(2), KRT16(2), KRT17(2), KRT18(2), KRT19(2), KRT2(1), KRT20(1), KRT23(1), KRT24(3), KRT25(3), KRT27(2), KRT28(1), KRT3(6), KRT31(4), KRT32(2), KRT33A(2), KRT33B(5), KRT34(4), KRT35(3), KRT36(2), KRT37(6), KRT38(2), KRT4(2), KRT5(4), KRT6A(4), KRT6B(2), KRT6C(2), KRT7(3), KRT71(3), KRT72(5), KRT73(4), KRT74(4), KRT75(6), KRT76(2), KRT77(1), KRT78(4), KRT79(3), KRT8(1), KRT81(1), KRT82(6), KRT83(1), KRT84(9), KRT85(6), KRT9(5), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), LMNB1(4), LMNB2(1), NES(7), PRPH(2), SPP1(1), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TNC(16), TNN(17), TNXB(17), VIM(3), VTN(6), VWF(15)	76404476	722	141	717	297	283	254	102	10	72	1	0.000036	0.0018
13	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(9), ARHGEF1(5), GNA12(2), GNA13(2), GNAQ(4), GNB1(1), GNGT1(1), MYL2(1), MYLK(14), PLCB1(8), PPP1R12B(9), PRKCA(4), ROCK1(15)	7003500	75	40	73	19	19	22	15	2	17	0	0.000049	0.0022
14	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	AICDA(4), AK3(1), CAD(11), CDA(1), CTPS(4), CTPS2(4), DCK(2), DCTD(3), DHODH(4), DPYS(7), DTYMK(1), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(2), ENTPD6(2), ITPA(2), NME6(4), NME7(5), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), PNPT1(10), POLA1(8), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1), RFC5(3), RRM1(2), RRM2(2), TK1(1), TK2(1), TXNRD1(3), TXNRD2(3), TYMS(3), UCK2(1), UMPS(1), UPB1(5), UPP2(2), UPRT(4)	26661776	238	77	234	57	70	90	49	1	28	0	0.000049	0.0022
15	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	139	ADA(3), ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADK(1), ADSL(7), ADSS(2), AK2(1), AK5(5), AK7(6), ALLC(5), AMPD1(9), AMPD2(5), AMPD3(3), ATIC(4), DCK(2), ENPP1(4), ENPP3(4), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(2), ENTPD6(2), FHIT(1), GART(3), GMPR(2), GMPR2(2), GMPS(5), GUCY1A2(12), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HPRT1(2), IMPDH1(2), IMPDH2(4), ITPA(2), NME6(4), NME7(5), NPR1(6), NPR2(10), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), NUDT9(2), PAICS(1), PAPSS1(2), PAPSS2(4), PDE10A(11), PDE11A(8), PDE1A(4), PDE1C(9), PDE3B(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE5A(6), PDE6D(1), PDE7A(3), PDE7B(4), PDE8A(1), PDE8B(7), PDE9A(6), PFAS(1), PKM2(2), PNPT1(10), POLA1(8), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1), PPAT(6), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RFC5(3), RRM1(2), RRM2(2), XDH(7)	54263732	479	109	472	151	162	165	84	2	66	0	0.000061	0.0025
16	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	CALR(1), CANX(2), CD4(2), CD74(1), CD8B(2), CIITA(7), CREB1(1), CTSB(5), CTSL1(4), CTSS(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(3), HSP90AB1(3), HSPA5(1), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(4), KIR3DL2(4), KIR3DL3(4), KLRC3(3), KLRC4(1), KLRD1(1), LGMN(3), NFYA(3), NFYB(1), NFYC(3), PDIA3(2), RFX5(1), RFXAP(1), TAP1(5), TAP2(5), TAPBP(5)	14893288	143	52	140	42	28	60	27	2	20	6	0.000079	0.0030
17	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	132	APC2(1), AXIN1(2), AXIN2(9), BTRC(5), CACYBP(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CCND2(1), CCND3(1), CER1(3), CHD8(6), CREBBP(25), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNBIP1(1), CUL1(8), CXXC4(1), DAAM1(2), DAAM2(9), DKK1(5), DVL2(9), DVL3(4), EP300(15), FBXW11(8), FZD1(1), FZD10(6), FZD2(2), FZD4(2), FZD6(6), FZD7(3), FZD8(1), LEF1(4), LRP5(5), LRP6(17), MAP3K7(4), MAPK8(7), MAPK9(5), MMP7(5), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NKD1(3), NKD2(1), NLK(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PORCN(2), PPARD(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2C(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRICKLE1(11), PRICKLE2(6), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PSEN1(3), RBX1(1), RHOA(5), ROCK1(15), ROCK2(6), RUVBL1(8), SENP2(3), SFRP1(3), SFRP2(3), SFRP4(4), SFRP5(1), SIAH1(1), SKP1(1), SMAD3(9), SOX17(2), TBL1X(6), TBL1XR1(6), TBL1Y(1), TCF7(6), TCF7L1(3), VANGL1(2), VANGL2(5), WIF1(2), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	48697452	463	116	456	138	181	136	83	5	58	0	0.00015	0.0053
18	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAQ(4), GNAS(6), GNB1(1), GNGT1(1), LIMK1(5), MAP2K1(4), MAPK1(2), MAPK3(3), MYL2(1), NOX1(1), PIK3C2G(9), PLCB1(8), PPP1R12B(9), PRKCA(4), PTK2(5), RAF1(6), ROCK2(6)	8616952	80	47	78	16	30	21	13	1	15	0	0.00017	0.0058
19	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(3), ARHGAP4(1), ARHGAP5(9), ARHGAP6(2), ARHGEF1(5), ARHGEF11(11), ARHGEF5(7), ARPC1A(5), ARPC1B(2), ARPC2(2), BAIAP2(1), CFL1(1), DIAPH1(1), LIMK1(5), MYL2(1), MYLK(14), OPHN1(7), PIP5K1A(3), PIP5K1B(2), PPP1R12B(9), ROCK1(15), SRC(3), TLN1(7), VCL(2)	15703444	120	61	118	36	40	32	24	2	22	0	0.00022	0.0071
20	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5)	4331412	53	30	53	14	16	19	10	0	7	1	0.00023	0.0071
21	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(8), CREM(4), FHL5(4), FSHB(2), FSHR(7), GNAS(6), XPO1(2)	3165356	33	29	33	12	13	9	7	1	3	0	0.00024	0.0072
22	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5), MASP1(12)	6647924	79	39	79	26	26	27	14	0	11	1	0.00036	0.010
23	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD3G(2), CD4(2), CREBBP(25), CSK(3), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(5), HLA-DRB1(2), LCK(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTPRC(17), ZAP70(4)	7622744	93	44	93	25	33	28	18	0	12	2	0.00052	0.013
24	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD3G(2), CD4(2), CREBBP(25), CSK(3), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(5), HLA-DRB1(2), LCK(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTPRC(17), ZAP70(4)	7622744	93	44	93	25	33	28	18	0	12	2	0.00052	0.013
25	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	6	CDK5R1(1), DAB1(7), FYN(5), LRP8(4), VLDLR(5)	2312944	22	19	21	10	6	8	0	1	7	0	0.00056	0.013
26	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	73	ABL1(4), ABL2(7), AKT1(2), AKT2(6), AKT3(1), ARAF(3), BAD(1), BTC(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CBL(5), CBLB(8), CDKN1A(1), CDKN1B(3), CRKL(2), EGF(3), EGFR(11), EREG(1), GAB1(6), GRB2(3), HBEGF(1), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(7), MAPK9(5), NCK1(1), NRG2(6), NRG3(7), NRG4(1), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PRKCA(4), PRKCG(10), PTK2(5), RAF1(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SRC(3), STAT5B(3)	28516904	242	84	237	81	87	75	44	3	33	0	0.00057	0.013
27	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5), MASP1(12), MASP2(4)	7255088	83	41	83	28	26	29	16	0	11	1	0.00084	0.019
28	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	134	ACTA1(4), ACTA2(3), ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADM(2), ARRB1(1), ATF1(2), ATF2(1), ATF3(1), ATF4(1), ATP2A2(6), ATP2A3(4), CACNB3(2), CALCA(4), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(13), CREB3(3), CRHR1(2), DGKZ(3), ETS2(3), FOS(1), GABPA(4), GABPB2(3), GBA2(5), GJA1(7), GNAQ(4), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), GRK4(5), GRK5(4), GRK6(3), GSTO1(1), GUCA2B(2), IGFBP1(2), IGFBP2(1), IGFBP3(4), IGFBP4(2), IL1B(1), IL6(2), ITPR1(19), ITPR2(18), ITPR3(12), MIB1(3), MYL2(1), MYL4(1), MYLK2(3), NFKB1(6), NOS1(11), NOS3(2), OXTR(3), PDE4B(5), PDE4D(4), PKIA(1), PKIB(1), PLCB3(4), PLCD1(7), PLCG1(4), PLCG2(13), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCH(3), PRKCQ(5), RAMP1(1), RAMP3(4), RGS1(1), RGS10(1), RGS16(2), RGS17(2), RGS18(2), RGS2(3), RGS20(4), RGS3(10), RGS4(3), RGS5(1), RGS6(3), RGS7(6), RGS9(7), RLN1(1), RYR1(25), RYR2(59), RYR3(42), SLC8A1(13), SP1(2), TNXB(17), USP5(4), YWHAB(2), YWHAH(1), YWHAQ(1)	56788712	549	126	543	192	234	175	87	1	51	1	0.00085	0.019
29	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	143	AKT1(2), AKT2(6), AKT3(1), BCL2L1(1), CBL(5), CBLB(8), CCND2(1), CCND3(1), CNTF(2), CNTFR(2), CREBBP(25), CSF2RB(7), CSF3R(10), EP300(15), GH1(2), GH2(3), GHR(6), GRB2(3), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), IFNK(1), IL10(2), IL10RA(2), IL10RB(5), IL11(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL13(1), IL13RA1(2), IL13RA2(3), IL15(1), IL15RA(1), IL19(1), IL2(4), IL20(3), IL20RA(5), IL21(2), IL21R(5), IL22(2), IL22RA1(1), IL23R(3), IL24(2), IL26(3), IL28RA(3), IL2RA(2), IL2RB(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL6ST(3), IL7(2), IL7R(3), IL9(2), IRF9(3), JAK1(4), JAK2(9), JAK3(8), LEP(1), LEPR(9), MPL(2), OSM(1), OSMR(6), PIAS1(4), PIAS2(3), PIAS3(4), PIAS4(1), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIM1(1), PRL(3), PRLR(4), PTPN11(5), PTPN6(4), SOCS2(3), SOCS4(1), SOCS5(4), SOS1(7), SOS2(11), SPRED1(7), SPRED2(6), SPRY1(3), SPRY4(2), STAM(2), STAM2(2), STAT1(6), STAT2(7), STAT3(2), STAT4(3), STAT5B(3), STAT6(2), TPO(11), TSLP(2), TYK2(1)	45825148	414	99	406	129	143	149	74	1	45	2	0.00092	0.019
30	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	BMPR1B(10), CCND2(1), CDK4(3), CDKN1B(3), DAZL(2), DMC1(4), EGR1(3), ESR2(2), FSHR(7), GJA4(2), INHA(2), LHCGR(4), MLH1(8), MSH5(5), NCOR1(12), NRIP1(6), PGR(4), PRLR(4), PTGER2(1), SMPD1(6), VDR(2), ZP2(7)	9571248	98	44	98	31	32	25	23	2	16	0	0.00095	0.019
31	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR1(5), AGTR2(5), ATP8A1(10), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), CCKAR(2), CCKBR(5), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CX3CR1(2), CXCR4(4), EDNRA(4), FPR1(2), FSHR(7), GALR1(2), GALT(2), GHSR(5), GNRHR(4), GPR77(2), GRPR(3), LHCGR(4), MC2R(5), MC3R(1), MC4R(4), MC5R(6), NPY1R(4), NPY2R(5), NPY5R(2), NTSR1(1), OPRD1(1), OPRK1(5), OPRM1(3), OXTR(3), PPYR1(4), SSTR1(5), SSTR2(3), SSTR4(4), TAC4(1), TACR1(2), TACR2(1), TACR3(7), TRHR(8), TSHR(7)	16599556	193	74	193	74	73	66	43	1	10	0	0.0011	0.021
32	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(3), AKR1D1(1), ARSD(3), ARSE(2), CARM1(2), CYP11B1(9), CYP11B2(5), CYP19A1(8), HSD11B1(1), HSD17B12(2), HSD17B2(2), HSD17B3(2), HSD17B8(1), HSD3B1(3), HSD3B2(1), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SRD5A1(1), SRD5A2(2), STS(7), SULT1E1(2), SULT2A1(2), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), WBSCR22(1)	15824172	144	60	142	32	43	50	29	2	20	0	0.0012	0.022
33	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(5), CBS(3), CTH(2), DNMT1(19), DNMT3A(9), DNMT3B(8), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), MTR(7)	5898820	71	38	66	15	34	18	6	3	10	0	0.0015	0.027
34	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(4), HLA-DRA(5), HLA-DRB1(2), IL3(3)	943012	14	12	13	4	7	5	0	0	0	2	0.0018	0.033
35	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(8), ARHGEF1(5), F2(3), GNA12(2), GNA13(2), GNAI1(4), GNAQ(4), GNB1(1), GNGT1(1), MAP3K7(4), PLCB1(8), PPP1R12B(9), PRKCA(4), PTK2B(1), ROCK1(15)	7465068	71	36	70	24	22	19	15	2	13	0	0.0021	0.037
36	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(11), EXTL1(3), EXTL2(6), EXTL3(9), GLCE(6), HS2ST1(4), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), NDST1(4), NDST2(5), NDST3(10), NDST4(4)	7050708	77	45	76	25	31	21	18	1	6	0	0.0022	0.038
37	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	CDH1(5), CREBBP(25), EP300(15), MAP2K1(4), MAP3K7(4), MAPK3(3), SKIL(1), TGFB1(1), TGFB2(9), TGFBR1(9)	6357648	76	38	75	19	26	18	18	1	13	0	0.0024	0.039
38	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(4), BMPR1B(10), BMPR2(10)	2094716	28	18	28	5	6	7	8	0	7	0	0.0024	0.039
39	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CDKN1B(3), CKS1B(1), CUL1(8), NEDD8(1), RB1(7), RBX1(1), SKP2(1), TFDP1(4)	2933124	31	24	31	7	7	4	10	1	8	1	0.0025	0.039
40	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(11), BDKRB2(3), C1QB(1), C1QC(3), C1R(3), C1S(6), C2(4), C3(11), C3AR1(4), C4BPA(7), C5(13), C5AR1(3), C6(13), C7(5), C8A(6), C9(5), CD46(3), CD55(4), CFB(4), CFH(16), CFI(2), CPB2(2), CR1(10), CR2(11), F10(1), F11(4), F12(2), F13B(5), F2(3), F3(2), F5(21), F7(3), F8(18), F9(6), FGB(2), FGG(4), KLKB1(6), KNG1(4), MASP1(12), MASP2(4), PLAT(5), PLAU(3), PLAUR(4), PLG(9), PROC(1), PROS1(6), SERPINA1(3), SERPINA5(4), SERPINC1(3), SERPIND1(2), SERPINE1(3), SERPING1(5), TFPI(3), THBD(2), VWF(15)	28959280	315	85	310	110	86	130	62	0	36	1	0.0026	0.039
41	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA6(5), GPX1(1), PRKCE(6)	2378852	38	22	37	6	11	17	6	0	4	0	0.0026	0.039
42	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(4), JAK2(9), JAK3(8), PIAS1(4), PIAS3(4), PTPRU(12), REG1A(5), SOAT1(1)	4742888	47	31	45	13	23	11	4	0	7	2	0.0027	0.039
43	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), CYP19A1(8), CYP1A1(7), CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(6), CYP4B1(9), CYP4F8(4), CYP51A1(3), PON1(6)	9878588	112	52	110	25	40	31	28	0	11	2	0.0029	0.041
44	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	28	ACVR1(4), ATF2(1), AXIN1(2), BMP10(3), BMP2(1), BMP4(2), BMP5(5), BMP7(6), BMPR1A(4), BMPR2(10), CHRD(5), FZD1(1), GATA4(1), MAP3K7(4), MEF2C(9), MYL2(1), NKX2-5(1), NPPA(1), NPPB(1), RFC1(14), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR3(8), WNT1(1)	8912252	104	40	102	28	36	32	18	0	18	0	0.0029	0.041
45	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(5), CALCRL(6), CD97(5), CRHR1(2), CRHR2(5), ELTD1(7), EMR1(8), EMR2(6), GHRHR(2), GLP1R(7), GLP2R(5), GPR64(6), LPHN1(3), LPHN2(13), LPHN3(17), SCTR(3), VIPR1(4), VIPR2(3)	9335368	109	48	106	36	40	36	22	0	11	0	0.0035	0.048
46	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(1), BHMT(5), CBS(3), CTH(2), DNMT1(19), DNMT3A(9), DNMT3B(8), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), MTAP(1), MTFMT(2), MTR(7), TAT(5)	7033116	80	40	75	18	35	25	6	3	11	0	0.0041	0.055
47	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(8), CD14(1), CD19(3), CD1A(3), CD1B(1), CD1C(1), CD1D(2), CD1E(6), CD2(3), CD22(10), CD33(2), CD34(1), CD36(1), CD37(2), CD38(2), CD3D(1), CD3G(2), CD4(2), CD44(3), CD5(4), CD55(4), CD7(1), CD8B(2), CD9(1), CR1(10), CR2(11), CSF1(2), CSF1R(3), CSF3R(10), DNTT(7), FCER2(1), FCGR1A(1), FLT3(5), FLT3LG(1), GP1BA(1), GP5(6), GYPA(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), IL11(1), IL11RA(1), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), IL2RA(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL7(2), IL7R(3), ITGA1(3), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGAM(8), ITGB3(9), KIT(8), KITLG(2), MME(10), MS4A1(4), TFRC(3), THPO(2), TPO(11)	27335152	266	79	260	87	100	103	37	4	20	2	0.0044	0.057
48	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAD(1), BAK1(1), BAX(1), BCL10(3), BCL2(1), BCL2L1(1), BCL2L11(3), BID(1), CASP8AP2(18), CASP9(2), CES1(5)	3871512	45	28	43	10	13	16	8	0	8	0	0.0044	0.057
49	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	105	ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), ARHGAP5(9), CDC42(1), CDH5(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNND1(6), CXCL12(1), CXCR4(4), CYBB(2), ESAM(3), EZR(2), F11R(1), GNAI1(4), GRLF1(12), ICAM1(2), ITGA4(8), ITGAL(8), ITGAM(8), ITGB1(6), ITGB2(5), JAM3(3), MAPK12(2), MAPK13(1), MAPK14(3), MLLT4(6), MMP2(5), MMP9(11), MSN(6), MYL2(1), MYL7(1), MYL9(2), NCF1(1), NCF2(2), NCF4(3), NOX1(1), NOX3(8), OCLN(1), PECAM1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PRKCA(4), PRKCG(10), PTK2(5), PTK2B(1), PTPN11(5), RAP1A(2), RAP1B(2), RAPGEF3(4), RAPGEF4(7), RASSF5(3), RHOA(5), RHOH(2), ROCK1(15), ROCK2(6), SIPA1(1), TXK(5), VASP(3), VAV1(13), VAV2(4), VAV3(12), VCAM1(9), VCL(2)	40133012	387	101	381	117	160	116	66	1	44	0	0.0049	0.062
50	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6)	1888992	24	19	24	9	3	9	11	0	1	0	0.0052	0.064
51	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(4), FMOD(2), KERA(7), LUM(6)	1221008	20	16	20	4	7	4	7	0	2	0	0.0057	0.068
52	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(2), FUT1(4), FUT2(1), FUT9(5), GCNT2(11), ST8SIA1(3)	2048552	28	18	28	7	10	9	5	0	4	0	0.0057	0.068
53	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(6), CHKA(4), PCYT1A(5), PDHA1(5), PDHA2(8), PEMT(1), SLC18A3(6)	2386116	37	26	36	17	12	12	10	0	3	0	0.0062	0.072
54	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	37	AKT1(2), ASAH1(3), ATF1(2), CREB1(1), CREB3(3), CREB5(4), CREBBP(25), CRKL(2), DAG1(5), EGR1(3), EGR2(8), EGR3(2), FRS2(4), GNAQ(4), MAP1B(30), MAPK1(2), MAPK3(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), NTRK1(6), OPN1LW(1), PIK3C2G(9), PIK3CD(3), PTPN11(5), RPS6KA3(5), SHC1(3), SRC(3), TERF2IP(2)	15070528	156	60	153	54	46	50	32	2	25	1	0.0065	0.074
55	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	119	ARAF(3), BID(1), CASP3(2), CD244(3), CD247(2), FAS(2), FASLG(1), FCGR3A(1), FYN(5), GRB2(3), GZMB(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-E(1), HLA-G(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), ITGAL(8), ITGB2(5), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(4), KIR3DL2(4), KLRC3(3), KLRD1(1), KLRK1(3), LAT(1), LCK(3), LCP2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MICB(3), NCR1(1), NCR3(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PAK1(5), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCA(4), PRKCG(10), PTK2B(1), PTPN11(5), PTPN6(4), RAF1(6), SH2D1A(2), SH2D1B(1), SH3BP2(1), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SYK(3), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(2), VAV1(13), VAV2(4), VAV3(12), ZAP70(4)	35773624	326	81	320	98	113	111	59	2	39	2	0.0066	0.074
56	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(1), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), APC2(1), ARAF(3), ARHGEF1(5), ARHGEF12(9), ARHGEF4(4), ARHGEF6(10), ARHGEF7(8), ARPC1A(5), ARPC1B(2), ARPC2(2), ARPC5(1), ARPC5L(2), BAIAP2(1), BDKRB2(3), CD14(1), CDC42(1), CFL1(1), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), CRKL(2), CSK(3), CYFIP1(6), CYFIP2(5), DIAPH1(1), DIAPH2(12), DIAPH3(5), DOCK1(7), EGF(3), EGFR(11), EZR(2), F2(3), FGD1(8), FGD3(2), FGF1(2), FGF11(3), FGF12(3), FGF13(3), FGF14(5), FGF17(1), FGF19(1), FGF20(2), FGF21(1), FGF23(1), FGF3(1), FGF5(4), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(4), FGFR2(6), FGFR3(2), FGFR4(2), FN1(21), GIT1(3), GNA12(2), GNA13(2), GRLF1(12), IQGAP1(13), IQGAP2(12), IQGAP3(11), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAD(8), ITGAE(7), ITGAL(8), ITGAM(8), ITGAV(5), ITGAX(6), ITGB1(6), ITGB2(5), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), LIMK1(5), LIMK2(5), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(3), MRAS(1), MSN(6), MYH10(10), MYH14(12), MYH9(12), MYL2(1), MYL7(1), MYL9(2), MYLK(14), MYLK2(3), NCKAP1(9), NCKAP1L(11), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDGFA(1), PDGFRA(17), PDGFRB(6), PFN2(1), PFN4(1), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PPP1R12B(9), PTK2(5), RAF1(6), RDX(3), RHOA(5), ROCK1(15), ROCK2(6), RRAS2(2), SCIN(3), SLC9A1(4), SOS1(7), SOS2(11), SSH1(6), SSH2(4), SSH3(1), TIAM1(17), TIAM2(16), TMSL3(1), VAV1(13), VAV2(4), VAV3(12), VCL(2), WAS(1), WASF1(3), WASF2(2), WASL(7)	90440932	800	138	790	270	315	246	143	8	86	2	0.0068	0.074
57	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	68	ARAF(3), C7orf16(4), CACNA1A(17), CRHR1(2), GNA11(1), GNA12(2), GNA13(2), GNAI1(4), GNAO1(5), GNAQ(4), GNAS(6), GNAZ(1), GRIA2(13), GRIA3(8), GRID2(12), GRM1(12), GRM5(11), GUCY1A2(12), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), IGF1(2), IGF1R(8), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(11), NOS3(2), NPR1(6), NPR2(10), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2C(4), PRKCA(4), PRKCG(10), PRKG1(9), PRKG2(5), RAF1(6), RYR1(25)	35574356	369	103	363	141	154	118	66	2	28	1	0.0080	0.086
58	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(22), ABCA10(10), ABCA13(40), ABCA3(6), ABCA4(14), ABCA5(17), ABCA6(17), ABCA7(5), ABCA8(17), ABCA9(18), ABCB1(11), ABCB10(3), ABCB11(11), ABCB4(11), ABCB5(14), ABCB6(4), ABCB7(4), ABCB8(5), ABCB9(2), ABCC1(11), ABCC10(7), ABCC11(11), ABCC12(11), ABCC2(14), ABCC3(5), ABCC4(9), ABCC5(7), ABCC6(7), ABCC8(8), ABCC9(11), ABCD1(3), ABCD2(9), ABCD3(3), ABCD4(5), ABCG1(6), ABCG2(9), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(12), TAP1(5), TAP2(5)	38041152	397	82	393	115	121	125	94	2	52	3	0.0081	0.086
59	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(2), BAD(1), BCL2(1), CABIN1(11), CAMK2B(2), CAMK4(3), CD3G(2), CD69(1), CDKN1A(1), CNR1(5), CREBBP(25), CSNK2A1(4), CSNK2B(2), CTLA4(2), EGR2(8), EGR3(2), EP300(15), FCER1A(3), FCGR3A(1), FOS(1), GATA3(4), GATA4(1), GRLF1(12), GSK3A(2), ICOS(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL13(1), IL1B(1), IL2(4), IL2RA(2), IL3(3), IL4(3), IL6(2), IL8(1), KPNA5(4), MAPK14(3), MAPK8(7), MAPK9(5), MEF2A(4), MEF2D(1), MYF5(4), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB2(4), NFKBIB(1), NFKBIE(2), NPPB(1), NUP214(6), OPRD1(1), P2RX7(3), PAK1(5), PIN1(1), PPP3CB(5), PPP3CC(4), PPP3R1(1), PTPRC(17), RELA(2), SLA(4), SP1(2), SP3(3), TGFB1(1), TRAF2(1), TRPV6(11), VAV1(13), VAV2(4), VAV3(12), XPO5(1)	29842888	289	76	286	97	106	87	57	4	35	0	0.0084	0.086
60	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(13), C6(13), C7(5), ICAM1(2), IL1A(1), IL6(2), IL8(1), ITGA4(8), ITGAL(8), ITGB1(6), ITGB2(5), SELP(6), SELPLG(2), VCAM1(9)	8384284	92	42	90	29	32	30	18	0	11	1	0.0084	0.086
61	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	67	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AKR1C2(4), AKR1C3(2), AKR1C4(3), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), CYP1A1(7), CYP1A2(3), CYP1B1(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2S1(3), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), DHDH(1), EPHX1(5), GSTA1(1), GSTA3(4), GSTA5(2), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), MGST1(2), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6)	18242264	182	63	182	44	46	62	51	1	21	1	0.0085	0.086
62	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	235	ACVR1C(3), AKT1(2), AKT2(6), AKT3(1), ARRB1(1), ATF2(1), ATF4(1), BDNF(1), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1F(14), CACNA1G(10), CACNA1H(2), CACNA1I(5), CACNA1S(14), CACNA2D1(11), CACNA2D2(1), CACNA2D3(6), CACNA2D4(3), CACNB1(1), CACNB2(6), CACNB3(2), CACNB4(2), CACNG1(2), CACNG2(3), CACNG4(2), CACNG5(5), CACNG6(1), CACNG8(1), CASP3(2), CD14(1), CDC25B(5), CDC42(1), CHUK(6), CRKL(2), DAXX(1), DUSP1(2), DUSP10(5), DUSP16(5), DUSP3(1), DUSP4(1), DUSP5(2), DUSP6(5), DUSP7(2), DUSP9(1), ECSIT(3), EGF(3), EGFR(11), ELK4(2), FAS(2), FASLG(1), FGF1(2), FGF11(3), FGF12(3), FGF13(3), FGF14(5), FGF17(1), FGF19(1), FGF20(2), FGF21(1), FGF23(1), FGF3(1), FGF5(4), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(4), FGFR2(6), FGFR3(2), FGFR4(2), FLNA(3), FLNB(16), FLNC(13), FOS(1), GNA12(2), GRB2(3), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K5(4), MAP2K6(3), MAP3K1(8), MAP3K10(3), MAP3K12(6), MAP3K13(9), MAP3K14(3), MAP3K2(3), MAP3K3(3), MAP3K5(6), MAP3K6(6), MAP3K7(4), MAP3K8(2), MAP4K1(3), MAP4K2(1), MAP4K3(4), MAP4K4(8), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK7(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAPT(5), MAX(1), MEF2C(9), MKNK1(1), MKNK2(3), MOS(3), MRAS(1), NF1(9), NFATC2(5), NFATC4(5), NFKB1(6), NFKB2(4), NLK(1), NR4A1(2), NTF3(1), NTRK1(6), NTRK2(4), PAK1(5), PAK2(3), PDGFA(1), PDGFRA(17), PDGFRB(6), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PPM1A(7), PPM1B(2), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(5), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF2(13), RASA1(9), RASA2(3), RASGRF1(12), RASGRF2(9), RASGRP1(5), RASGRP2(7), RASGRP3(7), RASGRP4(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA5(6), RRAS2(2), SOS1(7), SOS2(11), SRF(3), STK3(3), STK4(3), STMN1(2), TAOK1(5), TAOK2(3), TAOK3(4), TGFB1(1), TGFB2(9), TGFBR1(9), TNFRSF1A(1), TRAF2(1), TRAF6(4), ZAK(6)	94253556	804	131	793	296	329	221	160	7	81	6	0.0089	0.088
63	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5)	5951592	67	31	67	20	21	23	12	0	10	1	0.0090	0.088
64	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(2), CD4(2), FYN(5), HLA-DRA(5), HLA-DRB1(2), LCK(3), PTPRC(17), ZAP70(4)	3009476	41	22	41	9	10	16	6	0	7	2	0.0094	0.090
65	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(8), AKT1(2), ASAH1(3), GNAI1(4), GNB1(1), GNGT1(1), ITGAV(5), ITGB3(9), MAPK1(2), MAPK3(3), PDGFA(1), PDGFRA(17), PLCB1(8), PRKCA(4), PTK2(5), SMPD1(6), SPHK1(1), SRC(3)	7930692	83	41	83	31	27	23	20	2	10	1	0.0098	0.093
66	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(8), CAP1(1), CCNB1(2), CDC25C(4), GNAI1(4), GNAS(6), GNB1(1), GNGT1(1), MAPK1(2), MAPK3(3), MYT1(13), PIN1(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RPS6KA1(1), SRC(3)	6838796	67	46	66	21	26	27	10	0	4	0	0.011	0.098
67	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(9), AGT(5), AGTR1(5), AGTR2(5), ANPEP(8), CPA3(3), CTSA(3), CTSG(3), ENPEP(9), LNPEP(8), MAS1(2), MME(10), NLN(3), REN(5)	7110260	80	42	80	17	22	29	19	0	10	0	0.012	0.11
68	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(3), JAK1(4), JAK2(9), JAK3(8), PIAS3(4), PTPRU(12), REG1A(5), SRC(3), STAT3(2)	5233144	52	34	50	20	27	15	3	0	5	2	0.013	0.11
69	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALT1(6), B4GALT2(3), B4GALT3(7), FUT1(4), FUT2(1), FUT3(4), FUT6(1), FUT9(5), GCNT2(11), ST3GAL6(7), ST8SIA1(3)	5195836	61	34	61	14	25	17	12	1	6	0	0.014	0.13
70	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(7)	676032	11	9	11	2	3	3	4	0	1	0	0.015	0.13
71	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(8), GNAS(6), GNB1(1), GNGT1(1), PRKACA(1), PRKAR1A(5)	2167436	22	20	22	9	8	7	5	0	2	0	0.015	0.13
72	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(18), CPT1A(6), LEP(1), LEPR(9), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKAG1(1), PRKAG2(3)	4891292	53	29	51	20	20	17	10	0	6	0	0.015	0.13
73	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	CDC25A(2), CDC25B(5), CDC25C(4), CDK2(2), CDK4(3), CHEK1(1), MYT1(13), RB1(7), WEE1(3), YWHAH(1)	3601648	41	27	40	7	12	14	9	2	3	1	0.016	0.13
74	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(9), AGT(5), AGTR1(5), AGTR2(5), COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A6(15), REN(5)	7587156	76	37	75	15	20	25	17	1	13	0	0.016	0.13
75	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(2), B3GNT7(6), B4GALT1(6), B4GALT2(3), B4GALT3(7), CHST1(7), CHST2(1), CHST4(7), FUT8(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	4036676	51	32	51	15	29	6	10	1	5	0	0.016	0.13
76	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	ARFIP2(2), CDK5R1(1), CFL1(1), CHN1(2), LIMK1(5), MAP3K1(8), MYL2(1), MYLK(14), NCF2(2), PAK1(5), PDGFRA(17), PLD1(11), PPP1R12B(9), RALBP1(6), RPS6KB1(3), TRIO(13), VAV1(13), WASF1(3)	10561304	116	49	114	33	39	36	21	2	17	1	0.017	0.14
77	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(2), BAD(1), CREB1(1), CREB3(3), CREB5(4), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(1), GRB2(3), MAP2K1(4), MAP2K2(1), MAP3K8(2), MAPK1(2), MAPK3(3), MKNK1(1), MKNK2(3), MOS(3), NFKB1(6), RAP1A(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), SHC1(3), SOS1(7), SOS2(11), TRAF3(6)	9579636	92	43	91	23	28	32	16	2	14	0	0.018	0.15
78	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(1), ACAT1(1), ACAT2(2), ACMSD(4), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(8), CAT(3), CYP19A1(8), CYP1A1(7), CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(6), CYP4B1(9), CYP4F8(4), CYP51A1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(5), HAAO(2), HADHA(3), KMO(5), KYNU(7), MAOA(3), MAOB(1), SDS(2), TDO2(4), TPH1(3), WARS(2), WARS2(3)	18384232	197	68	196	56	68	69	42	1	16	1	0.019	0.15
79	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(4), GNB1(1), GNGT1(1), HTR2C(8), PLCB1(8), TUB(5)	2402460	30	20	30	9	14	5	6	1	4	0	0.020	0.15
80	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	79	ACVR1(4), ACVRL1(4), AKT1(2), AURKB(1), BMPR1A(4), BMPR2(10), BUB1(6), CDKL1(4), CDKL2(4), CDS1(2), CDS2(4), CLK1(6), CLK4(2), COL4A3BP(3), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), IMPA1(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPPL1(4), ITPKB(4), MAP3K10(3), MOS(3), NEK1(9), NEK3(4), OCRL(9), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3CB(2), PIK3CG(14), PIM2(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCG1(4), PLCG2(13), PLK3(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), PRKG1(9), RAF1(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), TGFBR1(9), VRK1(4)	37020356	339	93	333	98	136	100	69	2	32	0	0.022	0.17
81	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(11), GNAS(6), GNB1(1), GNGT1(1), GRB2(3), IGF1R(8), ITGB1(6), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(1), MKNK2(3), NGFR(3), PDGFRA(17), PPP2CA(1), PTPRR(5), RAF1(6), RPS6KA1(1), RPS6KA5(6), SHC1(3), SOS1(7), SRC(3), STAT3(2)	11021748	104	53	101	36	37	33	24	0	8	2	0.023	0.18
82	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(8), ARHGAP5(9), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(2), CASP9(2), GZMB(2)	3934756	30	24	29	10	4	11	7	0	8	0	0.024	0.18
83	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	6	CREBBP(25), EP300(15), MAPK1(2), MAPK3(3), PELP1(2), SRC(3)	4737824	50	32	50	15	17	13	13	1	6	0	0.024	0.18
84	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(8), CREB1(1), FOS(1), GNAI1(4), GNAQ(4), GNAS(6), GNB1(1), GNGT1(1), MAP2K1(4), MAPK3(3), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), RAF1(6), RPS6KA3(5), SYT1(1)	11537852	95	54	94	31	45	21	16	0	13	0	0.025	0.19
85	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(2), CD80(1), HLA-DRA(5), HLA-DRB1(2), IL10(2), IL2(4), IL4(3)	1281264	21	13	21	8	8	11	0	0	0	2	0.026	0.19
86	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(6)	242816	6	5	6	0	4	1	0	0	1	0	0.026	0.19
87	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(8), GNAS(6), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	5079204	49	35	48	19	22	15	8	0	4	0	0.027	0.19
88	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	88	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), AKAP10(3), AKAP11(7), AKAP12(14), AKAP3(10), AKAP4(4), AKAP5(3), AKAP6(16), AKAP7(3), AKAP8(3), AKAP9(26), ARHGEF1(5), GNA11(1), GNA12(2), GNA13(2), GNA14(6), GNA15(3), GNAL(4), GNAO1(5), GNAQ(4), GNAZ(1), GNB1(1), GNB3(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), IL18BP(2), ITPR1(19), KCNJ3(6), PDE1A(4), PDE1B(3), PDE1C(9), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE7A(3), PDE7B(4), PDE8A(1), PDE8B(7), PLCB3(4), PPP3CA(3), PPP3CC(4), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), PRKD3(8), RHOA(5), SLC9A1(4), USP5(4)	38178020	339	92	333	122	128	107	55	1	46	2	0.027	0.19
89	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(18), ACADL(2), ACADM(6), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), LDHA(2), LDHB(3), LDHC(2), MCEE(2), MLYCD(1), MUT(4), PCCA(9), PCCB(4), SDS(2), SUCLA2(5), SUCLG1(2)	11147916	119	45	117	24	42	38	20	1	18	0	0.028	0.19
90	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	5	ADAM17(7), NRG2(6), NRG3(7), PRKCA(4), PSEN1(3)	2126880	27	19	26	2	10	8	3	1	5	0	0.028	0.19
91	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	103	ABL1(4), ANAPC1(4), ANAPC10(2), ANAPC2(1), ANAPC4(4), ANAPC5(3), ANAPC7(4), ATR(17), BUB1(6), BUB1B(6), BUB3(2), CCNA1(6), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDC14A(4), CDC14B(4), CDC16(4), CDC20(3), CDC23(6), CDC25A(2), CDC25B(5), CDC25C(4), CDC6(1), CDC7(3), CDK2(2), CDK4(3), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(1), CREBBP(25), CUL1(8), DBF4(5), E2F2(1), E2F3(2), EP300(15), ESPL1(8), HDAC1(2), HDAC2(2), MAD1L1(2), MAD2L1(1), MAD2L2(1), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), PKMYT1(1), PLK1(8), PRKDC(18), PTTG1(1), RB1(7), RBL1(5), RBL2(8), RBX1(1), SKP1(1), SKP2(1), SMAD3(9), SMC1A(10), SMC1B(6), TFDP1(4), TGFB1(1), TGFB2(9), WEE1(3), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	42377568	336	83	334	93	101	106	75	7	46	1	0.028	0.19
92	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(2), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SDHB(2), SUCLA2(5)	3003212	26	23	26	9	9	8	5	0	4	0	0.029	0.19
93	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	17	HLA-A(3), ITGB1(6), KLRC3(3), KLRC4(1), KLRD1(1), LAT(1), MAP2K1(4), MAPK3(3), PAK1(5), PTK2B(1), PTPN6(4), SYK(3), VAV1(13)	4959168	48	30	48	12	17	13	10	1	7	0	0.029	0.19
94	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(2), HLA-DRA(5), HLA-DRB1(2)	743664	11	9	11	4	4	5	0	0	0	2	0.030	0.19
95	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(9), DIAPH1(1), FYN(5), ITGA1(3), ITGB1(6), MAP2K1(4), MAPK1(2), MAPK3(3), MYL2(1), MYLK(14), PTK2(5), RAF1(6), ROCK1(15), SHC1(3), SRC(3), TLN1(7)	11497936	87	48	84	24	27	29	18	0	13	0	0.030	0.19
96	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRA2A(3), ADRB1(3), ADRB3(1), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), DRD1(1), DRD2(5), DRD3(3), DRD5(6), HRH1(1), HRH2(4), HTR1A(5), HTR1B(5), HTR1D(2), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7)	7968192	90	47	89	40	43	26	11	1	9	0	0.031	0.19
97	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	DNM1(11), GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA6(5), NSF(1), SRC(3), UBQLN1(2)	3231760	48	25	46	19	11	23	9	0	5	0	0.031	0.19
98	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), GBA3(3), LPO(3), MPO(5), PRDX1(1), PRDX6(2), TPO(11), TYR(3)	3284228	35	27	34	16	19	7	4	0	5	0	0.031	0.19
99	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADRB1(3), CSNK1D(4), DRD1(1), DRD2(5), EGF(3), EGFR(11), GJA1(7), GJD2(1), GNA11(1), GNAI1(4), GNAQ(4), GNAS(6), GRB2(3), GRM1(12), GRM5(11), GUCY1A2(12), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HTR2A(3), HTR2B(1), HTR2C(8), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAP2K2(1), MAP2K5(4), MAP3K2(3), MAPK1(2), MAPK3(3), MAPK7(3), NPR1(6), NPR2(10), PDGFA(1), PDGFC(3), PDGFD(3), PDGFRA(17), PDGFRB(6), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKG1(9), PRKG2(5), PRKX(2), RAF1(6), SOS1(7), SOS2(11), SRC(3), TJP1(7), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3)	43276316	450	115	447	162	189	145	74	3	36	3	0.031	0.19
100	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(2), AKT2(6), AKT3(1), BAD(1), CASP9(2), CDC42(1), KDR(10), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPKAPK2(3), MAPKAPK3(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NOS3(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCG1(4), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCA(4), PRKCG(10), PTGS2(3), PTK2(5), RAF1(6), SH2D2A(2), SHC2(1), SPHK1(1), SPHK2(1), SRC(3), VEGFA(2)	22726392	175	66	171	65	84	40	27	0	24	0	0.032	0.19
101	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ACAD8(1), ACAD9(5), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(2), HSD3B7(2), LIPA(1), RDH11(1), RDH12(3), RDH13(1), SLC27A5(4), SOAT1(1), SOAT2(1), SRD5A1(1), SRD5A2(2)	10829152	93	45	93	33	24	39	23	0	7	0	0.033	0.20
102	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(4), FOS(1), GRB2(3), IGF1(2), IGF1R(8), IRS1(8), MAP2K1(4), MAPK3(3), MAPK8(7), PTPN11(5), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3)	6996356	73	39	71	14	22	26	17	1	7	0	0.034	0.21
103	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(8), CFTR(12), GNAS(6), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), SLC9A3R1(3)	4287168	42	30	42	13	15	13	9	0	5	0	0.035	0.21
104	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(7), FCER1A(3), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PAK2(3), PLA2G4A(8), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), RAF1(6), SHC1(3), SOS1(7), SYK(3), SYT1(1), VAV1(13)	12804368	119	50	116	30	46	31	23	1	18	0	0.036	0.21
105	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	61	ADCY1(8), ADCY8(12), ARAF(3), ATF4(1), CACNA1C(12), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CREBBP(25), EP300(15), GNAQ(4), GRIA2(13), GRIN1(1), GRIN2B(10), GRIN2C(4), GRIN2D(5), GRM1(12), GRM5(11), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF3(4), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5)	31657272	303	85	301	113	126	81	63	3	29	1	0.036	0.21
106	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(8), DBH(5), DCT(13), DDC(1), FAH(2), GOT1(6), GOT2(1), GSTZ1(2), HGD(2), HPD(4), MAOA(3), MAOB(1), TAT(5), TPO(11), TYR(3)	10479052	112	52	110	47	39	39	25	1	8	0	0.037	0.21
107	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(4), CYP11B1(9), CYP11B2(5), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD3B1(3), HSD3B2(1)	3002640	30	24	30	8	14	10	4	0	2	0	0.038	0.22
108	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(4), CYP11B1(9), CYP11B2(5), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD3B1(3), HSD3B2(1)	3002640	30	24	30	8	14	10	4	0	2	0	0.038	0.22
109	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(1), ARSB(5), ARSD(3), ARSE(2), CYP11B1(9), CYP11B2(5), HSD11B1(1), HSD17B2(2), HSD17B3(2), HSD17B8(1), HSD3B1(3), HSD3B2(1), SRD5A1(1), SRD5A2(2), STS(7), SULT1E1(2), SULT2A1(2), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3)	8780836	76	40	75	13	33	23	9	0	11	0	0.038	0.22
110	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(3), CAMK1G(5), FPR1(2), GNA15(3), GNB1(1), GNGT1(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), NCF1(1), NCF2(2), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), PAK1(5), PIK3C2G(9), PLCB1(8), PPP3CA(3), PPP3CB(5), PPP3CC(4), RAF1(6), RELA(2), SYT1(1)	13013564	114	49	113	38	43	29	19	4	19	0	0.040	0.22
111	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), LTB4R(1), P2RY1(6), P2RY2(3), P2RY6(1)	1894004	28	20	28	4	12	11	3	1	1	0	0.040	0.22
112	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), CD4(2), HLA-DRA(5), HLA-DRB1(2), IL1B(1), IL4(3), IL5RA(6), IL6(2)	1735984	25	15	24	8	11	12	0	0	0	2	0.040	0.22
113	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	11	AXIN1(2), CREBBP(25), EP300(15), FZD1(1), HDAC1(2), LDB1(5), LEF1(4), PITX2(2), TRRAP(21), WNT1(1)	8204472	78	42	77	25	34	16	16	1	11	0	0.041	0.22
114	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(6), CCNE1(3), CDK2(2), CUL1(8), RB1(7), SKP2(1), TFDP1(4)	2955912	31	22	31	8	7	5	11	1	6	1	0.042	0.22
115	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	12	CASR(7), GABBR1(6), GPRC5A(2), GPRC5B(2), GPRC5C(2), GPRC5D(1), GRM1(12), GRM2(4), GRM3(7), GRM4(7), GRM5(11), GRM8(9)	6173320	70	40	69	45	31	21	10	1	7	0	0.042	0.22
116	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	39	CD3D(1), CD3G(2), FOS(1), FYN(5), GRB2(3), LAT(1), LCK(3), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), PTPN7(2), RAF1(6), RASA1(9), RELA(2), SHC1(3), SOS1(7), SYT1(1), VAV1(13), ZAP70(4)	14518312	128	52	126	36	53	34	20	1	20	0	0.042	0.22
117	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(8), G6PD(3), GCLC(4), GCLM(1), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GSS(4), GSTA1(1), GSTA3(4), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), PGD(1)	5714284	60	33	60	8	13	25	16	0	6	0	0.043	0.22
118	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(1), UGDH(4), UGP2(7), UXS1(7)	1709536	22	16	22	5	7	8	4	0	3	0	0.043	0.22
119	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(1), ALDH4A1(3), ALDH5A1(4), CAD(11), CPS1(14), EPRS(12), GAD1(9), GAD2(4), GCLC(4), GCLM(1), GFPT1(4), GFPT2(4), GLS2(2), GLUD1(2), GLUD2(6), GLUL(4), GMPS(5), GOT1(6), GOT2(1), GPT2(2), GSR(1), GSS(4), NADSYN1(2), NAGK(2), PPAT(6), QARS(8)	13279336	127	55	126	33	44	42	28	3	10	0	0.045	0.23
120	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	89	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ATF4(1), CACNA1C(12), CACNA1D(8), CACNA1F(14), CACNA1S(14), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CDC42(1), CGA(2), EGFR(11), FSHB(2), GNA11(1), GNAQ(4), GNAS(6), GNRHR(4), GRB2(3), HBEGF(1), ITPR1(19), ITPR2(18), ITPR3(12), LHB(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K2(3), MAP3K3(3), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK7(3), MAPK8(7), MAPK9(5), MMP14(4), MMP2(5), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLD1(11), PLD2(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(3), PRKX(2), PTK2B(1), RAF1(6), SOS1(7), SOS2(11), SRC(3)	41262708	352	97	349	124	142	106	65	4	34	1	0.045	0.23
121	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(3), AASS(9), KARS(3)	1596912	16	13	16	4	4	4	5	0	3	0	0.046	0.23
122	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(2), SOAT2(1), SRD5A1(1), SRD5A2(2)	7894272	80	40	80	23	22	30	23	0	5	0	0.050	0.25
123	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(3), AKT1(2), ASAH1(3), CAV3(3), DAG1(5), DLG4(3), EPHB2(8), GNAI1(4), GNAQ(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), PITX2(2), PTX3(2), RHO(3), RYR1(25)	13839816	131	60	130	54	63	38	17	0	12	1	0.050	0.25
124	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	14	CD28(2), CD3D(1), CD3G(2), CD80(1), CTLA4(2), GRB2(3), HLA-DRA(5), HLA-DRB1(2), ICOS(1), IL2(4), LCK(3), PTPN11(5)	2537776	31	18	31	7	9	17	2	0	1	2	0.050	0.25
125	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(4), GNB1(1), GNGT1(1), ITGA1(3), ITGB1(6), MAP2K1(4), MAPK1(2), MAPK3(3), PLA2G4A(8), PLCB1(8), PRKCA(4), PTGS1(6), PTK2(5), RAF1(6), SRC(3), SYK(3), TBXAS1(5)	8223816	75	40	73	22	29	21	17	1	7	0	0.051	0.25
126	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(3), BFAR(1), CREB1(1), CREB3(3), CREB5(4), MAPK1(2), RAF1(6), SNX13(9), SRC(3), TERF2IP(2)	3434684	34	20	33	12	12	9	7	1	5	0	0.053	0.26
127	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(26), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAR2B(3), PRKCE(6)	4851972	41	25	40	11	16	11	5	0	9	0	0.054	0.26
128	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	CXCL12(1), CXCR4(4), GNAI1(4), GNAQ(4), GNB1(1), GNGT1(1), MAP2K1(4), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(9), PLCG1(4), PRKCA(4), PTK2(5), PTK2B(1), RAF1(6), RELA(2)	8234468	61	35	60	19	26	15	10	0	10	0	0.055	0.26
129	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	53	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AGK(3), AGPAT1(2), AGPAT3(3), AGPAT6(2), AKR1B1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CEL(1), DAK(4), DGAT2(4), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), GK(3), GK2(6), GLA(4), GLB1(3), GPAM(3), LCT(20), LIPA(1), LIPC(4), LIPF(3), LIPG(2), LPL(6), MGLL(1), PNLIP(7), PNLIPRP1(4), PNLIPRP2(2), PNPLA3(4), PPAP2B(1)	19401284	198	62	198	64	64	77	42	0	15	0	0.058	0.28
130	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	CDC25A(2), CDC25B(5), CDC25C(4), CHEK1(1), MYT1(13), WEE1(3), YWHAH(1)	2566992	29	21	28	4	9	12	5	1	2	0	0.058	0.28
131	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), GBA3(3), LPO(3), MPO(5), PRDX6(2), TPO(11)	2867192	31	25	30	14	18	7	2	0	4	0	0.062	0.29
132	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(7), CD79A(3), CD79B(1), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK14(3), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), RAF1(6), SHC1(3), SOS1(7), SYK(3), SYT1(1), VAV1(13)	12787560	115	50	113	31	46	33	19	1	16	0	0.063	0.29
133	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(8), G6PD(3), GCLC(4), GCLM(1), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GPX6(3), GSR(1), GSS(4), GSTA1(1), GSTA3(4), GSTA5(2), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), TXNDC12(2)	6949940	67	36	67	10	14	27	19	0	7	0	0.064	0.29
134	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(10), CR2(11), HLA-DRA(5), HLA-DRB1(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	5071208	61	28	61	16	15	26	10	0	8	2	0.064	0.29
135	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(6), NR1I3(3), PTGS1(6), PTGS2(3)	1776376	21	17	21	6	9	7	4	0	1	0	0.065	0.29
136	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(5), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), DHRS1(1), DHRS2(3), DHRS3(2), ESCO1(11), ESCO2(4), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4)	8215268	88	40	87	31	28	27	26	1	6	0	0.065	0.29
137	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(3), JAK1(4), JAK2(9), PTPRU(12), REG1A(5), STAT1(6)	3888348	40	24	38	11	20	8	7	0	3	2	0.065	0.29
138	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(4), FOS(1), GRB2(3), INSR(6), IRS1(8), MAP2K1(4), MAPK3(3), MAPK8(7), PTPN11(5), RAF1(6), RASA1(9), SHC1(3), SLC2A4(4), SOS1(7), SRF(3)	7253876	73	38	71	18	19	27	18	1	8	0	0.069	0.30
139	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(6), DARS(4), EPRS(12), FARS2(5), GARS(3), HARS(2), IARS(6), KARS(3), LARS(5), LARS2(3), MARS(6), MARS2(1), NARS(3), QARS(8), RARS(4), SARS(2), TARS(6), WARS(2), WARS2(3), YARS(2)	10758584	91	43	91	16	30	26	23	2	10	0	0.069	0.30
140	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	2644184	30	22	30	6	15	5	7	0	3	0	0.069	0.30
141	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(2), BAD(1), GRB2(3), IGF1R(8), IRS1(8), MAP2K1(4), MAPK1(2), MAPK3(3), RAF1(6), SHC1(3), SOS1(7), YWHAH(1)	5031620	48	33	46	11	16	17	10	0	5	0	0.070	0.31
142	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(5), AGTR2(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), F2(3), FYN(5), GNA11(1), GNAI1(4), GNB1(1), GNGT1(1), GRB2(3), JAK2(9), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), MAPT(5), MYLK(14), PLCG1(4), PRKCA(4), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), STAT1(6), STAT3(2), SYT1(1)	14153160	118	50	116	37	32	43	29	1	11	2	0.070	0.31
143	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(4), CREBBP(25), DFFA(3), DFFB(2), GZMA(3), GZMB(2), HMGB2(1)	3603940	41	25	41	11	12	13	9	0	7	0	0.072	0.31
144	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(3), CDK2(2), CUL1(8), RB1(7), TFDP1(4)	2300712	24	18	24	6	5	3	9	1	5	1	0.074	0.31
145	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ABP1(1), ACAT1(1), ACAT2(2), ACMSD(4), AFMID(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(8), CARM1(2), CAT(3), CYP1A1(7), CYP1A2(3), CYP1B1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(5), HAAO(2), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), INMT(2), KMO(5), KYNU(7), LCMT1(3), LCMT2(2), LNX1(11), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), NFX1(8), OGDH(4), OGDHL(11), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), TDO2(4), TPH1(3), TPH2(8), WARS(2), WARS2(3), WBSCR22(1)	20235148	193	68	191	60	66	67	37	3	20	0	0.074	0.31
146	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), FH(1), IDH2(7), MDH1(1), OGDH(4), SDHA(6), SUCLA2(5)	3178052	26	23	26	10	11	6	5	0	4	0	0.075	0.32
147	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(18), ACACB(15), ACADM(6), ACAT1(1), ACAT2(2), ACSS1(3), ACSS2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH7A1(3), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), HIBCH(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), MCEE(2), MLYCD(1), MUT(4), PCCA(9), PCCB(4), SUCLA2(5), SUCLG1(2)	13361500	133	50	131	30	45	46	21	2	19	0	0.076	0.32
148	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), HLA-DRA(5), HLA-DRB1(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL11(1), IL12A(1), IL12B(2), IL13(1), IL15(1), IL1A(1), IL2(4), IL3(3), IL4(3), IL6(2), IL7(2), IL8(1), PDGFA(1), TGFB1(1), TGFB2(9)	4404944	49	24	48	22	18	22	3	0	4	2	0.076	0.32
149	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	67	ACP1(2), ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), ACVR1C(3), BAIAP2(1), CDC42(1), CDH1(5), CREBBP(25), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNND1(6), EGFR(11), EP300(15), FARP2(5), FER(6), FGFR1(4), FYN(5), IGF1R(8), INSR(6), IQGAP1(13), LEF1(4), LMO7(19), MAP3K7(4), MAPK1(2), MAPK3(3), MET(5), MLLT4(6), NLK(1), PARD3(7), PTPN1(5), PTPN6(4), PTPRB(4), PTPRF(9), PTPRJ(4), PVRL1(6), PVRL2(4), PVRL3(2), PVRL4(4), RHOA(5), SMAD3(9), SNAI1(1), SNAI2(2), SORBS1(11), SRC(3), SSX2IP(4), TCF7(6), TCF7L1(3), TGFBR1(9), TJP1(7), VCL(2), WAS(1), WASF1(3), WASF2(2), WASF3(4), WASL(7), YES1(1)	36132284	351	85	347	110	137	112	59	4	38	1	0.078	0.32
150	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(7), LPO(3), MPO(5), MTHFR(7), PRDX6(2), SHMT1(2), SHMT2(2), TPO(11)	3940752	43	30	42	16	24	11	5	0	3	0	0.078	0.32
151	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYB(1), NFYC(3), RB1(7), SP1(2), SP3(3)	2252028	19	15	19	4	4	8	5	0	1	1	0.079	0.32
152	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(1), FARSB(8), GOT1(6), GOT2(1), PAH(4), TAT(5), YARS(2), YARS2(4)	2933008	36	20	35	7	10	13	7	0	6	0	0.081	0.33
153	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	10	COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A6(15), P4HB(2), SLC23A1(2), SLC23A2(7), SLC2A1(1), SLC2A3(1)	7547300	60	32	59	16	18	17	11	1	13	0	0.081	0.33
154	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(8), BAD(1), BAX(1), BCL2(1), BCL2A1(3), BCL2L1(1), BOK(1), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP9(2), CD40(1), CD40LG(6), CRADD(2), DAXX(1), DFFA(3), DFFB(2), FAS(2), FASLG(1), IKBKE(4), NFKB1(6), NGFR(3), NR3C1(4), NTRK1(6), PTPN13(17), RIPK1(2), SFRS2IP(3), TFG(6), TNFRSF1A(1), TRADD(1), TRAF1(2), TRAF2(1), TRAF3(6), TRAF6(4)	14526248	118	52	116	53	34	43	22	1	17	1	0.085	0.34
155	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(3), ALG6(3), CCKBR(5), CCR3(4), CCR5(1), CELSR1(8), CELSR2(9), CELSR3(5), CHRM3(4), EDNRA(4), EMR2(6), EMR3(8), FSHR(7), GHRHR(2), GNRHR(4), GPR116(11), GPR132(1), GPR133(8), GPR143(2), GPR17(1), GPR18(2), GPR55(1), GPR56(2), GPR61(4), GPR77(2), GPR84(6), GPR88(1), GRM1(12), GRPR(3), HRH4(2), LPHN2(13), LPHN3(17), NTSR1(1), OR8G2(1), P2RY13(2), PTGFR(7), SMO(1), SSTR2(3), TAAR5(6), TSHR(7), VN1R1(4)	21630120	193	73	188	81	77	56	38	5	17	0	0.090	0.36
156	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1)	4511676	51	30	51	15	13	20	16	0	2	0	0.090	0.36
157	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(8), CARM1(2), DBH(5), DCT(13), DDC(1), ECH1(1), ESCO1(11), ESCO2(4), FAH(2), GOT1(6), GOT2(1), GSTZ1(2), HGD(2), HPD(4), LCMT1(3), LCMT2(2), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), MYST3(18), MYST4(10), PNPLA3(4), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SH3GLB1(4), TAT(5), TPO(11), TYR(3), TYRP1(2), WBSCR22(1)	19823904	199	67	195	74	69	66	45	4	15	0	0.091	0.36
158	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(2), CD3D(1), CD3G(2), IFNG(1), IL2(4), IL2RA(2), IL4(3), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR3(8), TOB1(2), TOB2(1)	3205320	45	20	44	13	17	15	6	0	7	0	0.092	0.36
159	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(6), BCMO1(4), RDH5(1)	1303708	15	13	15	2	6	4	4	0	1	0	0.092	0.36
160	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), FOS(1), GRB2(3), IL6(2), IL6R(3), IL6ST(3), JAK1(4), JAK2(9), JAK3(8), MAP2K1(4), MAPK3(3), PTPN11(5), RAF1(6), SHC1(3), SOS1(7), SRF(3), STAT3(2)	8097604	70	37	67	16	22	26	12	0	8	2	0.095	0.37
161	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(6), CREBBP(25), DUSP1(2), EP300(15), IKBKB(4), IL1B(1), IL8(1), MAP2K3(6), MAP2K6(3), MAP3K14(3), MAP3K7(4), MAPK14(3), MYD88(2), NFKB1(6), NR3C1(4), RELA(2), TGFBR1(9), TLR2(6)	9617228	102	40	101	32	33	28	27	3	11	0	0.097	0.37
162	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(4), CDC40(4), CLK3(3), CLK4(2), COL2A1(9), CPSF1(5), CPSF2(1), CPSF3(2), CPSF4(4), CSTF1(2), CSTF2T(7), CSTF3(4), DDX1(4), DDX20(4), DHX15(3), DHX16(6), DHX38(11), DHX8(6), DHX9(5), DICER1(8), DNAJC8(2), LSM2(1), METTL3(4), NCBP1(6), NCBP2(1), NONO(2), NUDT21(1), NXF1(7), PABPN1(1), PAPOLA(3), PHF5A(1), POLR2A(6), PPM1G(1), PRPF18(4), PRPF3(1), PRPF4(4), PRPF4B(9), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(4), RBM17(2), RBM5(3), RNGTT(6), RNMT(4), RNPS1(1), SF3A1(3), SF3A2(1), SF3A3(1), SF3B1(10), SF3B2(2), SF3B4(4), SFRS14(2), SFRS4(2), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD3(1), SNRPE(2), SNRPN(2), SNURF(1), SPOP(2), SRPK1(9), SRPK2(4), SRRM1(11), SUPT5H(11), TXNL4A(1), U2AF1(2), U2AF2(3), XRN2(8)	35458112	266	77	266	73	85	76	62	3	40	0	0.10	0.38
163	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(2), HGD(2)	576560	6	5	6	4	1	2	2	0	1	0	0.10	0.38
164	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(6), CARS(6), CARS2(1), DARS(4), DARS2(3), EPRS(12), FARS2(5), FARSA(1), FARSB(8), GARS(3), HARS(2), HARS2(4), IARS(6), IARS2(6), KARS(3), LARS(5), LARS2(3), MARS(6), MARS2(1), MTFMT(2), NARS(3), NARS2(6), QARS(8), RARS(4), RARS2(5), SARS(2), SARS2(2), TARS(6), TARS2(5), VARS(1), VARS2(6), WARS(2), WARS2(3), YARS(2), YARS2(4)	17925080	151	55	150	29	52	44	34	2	19	0	0.11	0.40
165	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	24	CPEB1(5), EGFR(11), ETS1(1), ETS2(3), ETV6(5), FMN2(7), GRB2(3), MAP2K1(4), MAPK1(2), MAPK3(3), NOTCH2(13), NOTCH3(15), NOTCH4(7), PIWIL1(8), PIWIL2(10), PIWIL3(10), PIWIL4(8), RAF1(6), SOS1(7), SOS2(11), SPIRE1(3), SPIRE2(1)	14765660	143	60	141	40	49	52	28	2	12	0	0.11	0.40
166	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	AKR1B1(3), GUSB(2), RPE(2), UGDH(4), UGP2(7), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), XYLB(2)	8058360	74	30	74	16	17	30	16	0	11	0	0.11	0.40
167	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(6), DBH(5), DDC(1), GAD1(9), GAD2(4), HDC(8), MAOA(3), PAH(4), SLC18A3(6), TPH1(3)	4854580	51	35	51	24	19	20	9	0	3	0	0.11	0.40
168	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	5	BAAT(2), CDO1(1), CSAD(2), GAD1(9), GAD2(4)	1593012	18	15	18	6	8	8	2	0	0	0	0.11	0.40
169	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(2), BDKRB2(3), CAV1(1), CHRM1(3), CHRNA1(4), FLT1(12), FLT4(5), KDR(10), NOS3(2), PDE3A(5), PDE3B(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKG1(9), PRKG2(5), RYR2(59), SLC7A1(2), SYT1(1), TNNI1(2)	13801952	145	54	145	56	46	54	31	1	13	0	0.11	0.41
170	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(6), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK4(3), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), RB1(7), RBL1(5), TFDP1(4)	5369992	46	31	46	12	14	10	13	1	7	1	0.11	0.41
171	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(4), AASDHPPT(3), AASS(9), KARS(3)	2347060	20	15	20	8	5	6	6	0	3	0	0.11	0.41
172	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(4), B3GALT5(4), FUT1(4), FUT2(1), FUT9(5), GLA(4), HEXB(3), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST8SIA1(3)	3554180	34	20	33	12	14	8	7	0	5	0	0.12	0.41
173	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(1), JAK1(4), PTPRU(12), REG1A(5), STAT1(6), STAT2(7), TYK2(1)	4233004	39	27	37	9	22	7	6	0	4	0	0.12	0.41
174	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(7), ALG11(1), ALG12(2), ALG13(1), ALG14(1), ALG2(3), ALG3(1), ALG5(3), ALG6(3), ALG8(6), ALG9(2), B4GALT1(6), B4GALT2(3), B4GALT3(7), DAD1(2), DDOST(2), DHDDS(1), DPAGT1(2), DPM1(1), FUT8(2), GANAB(4), MAN1A1(5), MAN1A2(2), MAN1B1(2), MAN1C1(7), MAN2A1(12), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), RPN2(1), ST6GAL1(1), STT3B(6)	14281672	112	52	110	28	37	36	30	0	9	0	0.12	0.42
175	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	91	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(3), CREB3L1(3), CREB3L2(4), CREB3L3(3), CREB3L4(1), CREBBP(25), DCT(13), DVL2(9), DVL3(4), EDN1(1), EP300(15), FZD1(1), FZD10(6), FZD2(2), FZD4(2), FZD6(6), FZD7(3), FZD8(1), GNAI1(4), GNAO1(5), GNAQ(4), GNAS(6), KIT(8), KITLG(2), LEF1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MITF(5), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), POMC(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), RAF1(6), TCF7(6), TCF7L1(3), TYR(3), TYRP1(2), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	33574956	314	94	311	125	134	93	50	5	32	0	0.12	0.42
176	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1C1(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(2), GALNT13(5), GALNT14(10), GALNT2(4), GALNT3(4), GALNT5(10), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GALNTL1(5), GALNTL2(8), GALNTL4(2), GALNTL5(8), GCNT1(5), GCNT3(4), GCNT4(7), OGT(5), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(3)	10485352	109	44	108	28	37	41	17	0	14	0	0.12	0.42
177	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	48	ACTA1(4), AGT(5), AKT1(2), CALR(1), CAMK1(3), CAMK1G(5), CAMK4(3), CREBBP(25), CSNK1A1(2), EDN1(1), ELSPBP1(1), F2(3), GATA4(1), HAND1(2), HAND2(2), IGF1(2), MAP2K1(4), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), MEF2C(9), MYH2(12), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NKX2-5(1), NPPA(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RAF1(6), RPS6KB1(3), SYT1(1)	15336960	156	55	155	46	60	42	32	1	21	0	0.12	0.42
178	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(6), CCNA2(3), CCNE1(3), CCNE2(2), CDK2(2), CDK4(3), CDKN1B(3), CDKN2A(1), E2F2(1), E2F4(1), PRB1(1)	2935608	26	20	26	7	7	6	7	1	5	0	0.12	0.42
179	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(1), ALDOB(5), ALDOC(3), TPI1(1)	1279096	14	13	14	1	4	7	3	0	0	0	0.12	0.42
180	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(7), ADCY4(9), ADCY6(1), ADCY8(12), CACNA1A(17), CACNA1B(11), GNAS(6), GNAT3(2), GNB1(1), GNB3(3), GNG3(2), GRM4(7), ITPR3(12), KCNB1(5), PDE1A(4), PLCB2(3), PRKACA(1), PRKACB(1), PRKACG(3), PRKX(2), SCNN1A(3), SCNN1B(4), SCNN1G(5), TAS1R1(7), TAS1R2(7), TAS2R1(2), TAS2R10(6), TAS2R13(3), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R41(1), TAS2R46(2), TAS2R5(2), TAS2R50(5), TAS2R60(2), TAS2R7(1), TAS2R8(2), TAS2R9(3)	19170972	177	68	174	67	75	61	29	0	12	0	0.13	0.42
181	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADL(2), ACADM(6), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH9A1(1), AOX1(8), BCAT1(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HMGCL(1), MCCC1(8), MCCC2(2), MCEE(2), MUT(4), OXCT1(3), PCCA(9), PCCB(4), SDS(2)	12168408	113	48	112	27	41	41	15	0	16	0	0.13	0.42
182	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	19	ADCY1(8), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(1), CSF2RB(7), IGF1(2), IGF1R(8), IL3(3), KIT(8), KITLG(2), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), YWHAH(1)	5784420	58	37	57	24	27	18	8	0	5	0	0.13	0.42
183	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(7), PARK2(6), SNCA(1), SNCAIP(3), UBE2E2(1), UBE2F(1), UBE2G1(2), UBE2L3(2)	2137016	23	17	23	8	6	11	5	0	1	0	0.13	0.42
184	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(5), ACTN2(8), ACTN3(3), BCR(7), CAPN1(2), CAPNS1(1), CAPNS2(1), CAV1(1), CRKL(2), CSK(3), FYN(5), GRB2(3), ITGA1(3), ITGB1(6), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(7), PPP1R12B(9), PTK2(5), RAF1(6), RAP1A(2), ROCK1(15), SHC1(3), SOS1(7), SRC(3), TLN1(7), VCL(2), ZYX(1)	15965992	131	60	128	36	51	43	25	1	11	0	0.13	0.42
185	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(5), EGF(3), EGFR(11), GRB2(3), MAP2K1(4), MAPK1(2), MAPK3(3), PTPRB(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SPRY1(3), SPRY4(2), SRC(3)	8266640	68	35	66	25	24	21	17	0	6	0	0.13	0.42
186	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(3), AKT1(2), ANGPTL2(8), DAG1(5), DGKA(1), ETFA(3), ITGA9(6), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAPK1(2), MAPK3(3), NR1I3(3), PAK1(5), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(9), PIK3CD(3), PLDN(1), RIPK3(4), RPS4X(2), SGCB(4), VASP(3)	15493376	135	53	135	40	49	37	24	3	20	2	0.13	0.42
187	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	33	AKT1(2), ATF1(2), CDC42(1), CREB1(1), CREB3(3), CREB5(4), DUSP1(2), DUSP10(5), EEF2K(1), IL1R1(4), MAP2K3(6), MAP2K6(3), MAP3K10(3), MAP3K5(6), MAP3K7(4), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MKNK1(1), MKNK2(3), MYEF2(7), NFKB1(6), NR2C2(4), SRF(3), TRAF6(4)	10002000	87	42	87	20	27	27	19	3	11	0	0.13	0.42
188	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(2), PLCB1(8), PLCG1(4), PRKCA(4), VAV1(13)	3087972	31	24	31	12	14	9	5	1	2	0	0.13	0.42
189	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	29	AKT1(2), AR(6), ASAH1(3), CCL13(1), CCL15(1), DAG1(5), EGFR(11), GNA11(1), GNA15(3), GNAI1(4), GNAQ(4), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), MAPK14(3), PHKA2(6), PIK3CD(3), PITX2(2), PTX3(2), RAF1(6), SRC(3)	14211388	134	58	133	54	63	36	23	0	11	1	0.13	0.42
190	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(5), GTF2F2(1), GTF2H1(4), GTF2H3(4), GTF2H4(1), GTF2IRD1(9), TAF1(12), TAF2(8), TAF4(5), TAF4B(6), TAF5(4), TAF5L(2), TAF6(3), TAF6L(2), TAF7(2), TAF7L(4), TAF9(1), TAF9B(1), TBPL1(1), TBPL2(1)	10882476	84	43	84	18	30	22	21	0	11	0	0.13	0.43
191	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(2), CREB1(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), NFKB1(6), RB1(7), RELA(2), SP1(2)	5375656	50	27	50	13	17	13	12	2	5	1	0.13	0.43
192	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(4), ACO2(2), ACSS1(3), ACSS2(6), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SUCLA2(5)	4470360	37	26	37	12	15	11	6	1	4	0	0.14	0.45
193	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(4), FOS(1), GRB2(3), JAK1(4), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), PDGFA(1), PDGFRA(17), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3), STAT1(6), STAT3(2)	10211944	96	39	93	26	29	32	23	1	10	1	0.14	0.45
194	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(3), EPX(7), LPO(3), MPO(5), PRDX1(1), PRDX6(2), SHMT1(2), SHMT2(2), TPO(11)	4010432	37	28	36	16	22	8	3	0	4	0	0.14	0.45
195	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPPL1(4), ITPKB(4), MIOX(1), OCRL(9), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3CB(2), PIK3CG(14), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCG1(4), PLCG2(13)	14561824	121	53	119	33	50	38	21	1	11	0	0.14	0.45
196	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(5), FOS(1), MAP2K1(4), MAPK1(2), MAPK3(3), NFKB1(6), PLCB1(8), PRKCA(4), RAF1(6), RELA(2)	5163740	41	24	40	14	18	9	8	1	5	0	0.14	0.45
197	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	37	AR(6), ESR2(2), ESRRA(3), HNF4A(6), NPM1(1), NR0B1(3), NR1D1(4), NR1D2(6), NR1H3(4), NR1I2(2), NR1I3(3), NR2C2(4), NR2E1(2), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(4), NR4A1(2), NR4A2(7), NR5A2(4), PGR(4), PPARA(1), PPARD(2), PPARG(1), RARG(5), ROR1(9), RORA(2), RORC(1), RXRA(1), RXRB(3), RXRG(4), THRA(2), THRB(4), VDR(2)	12308568	113	55	112	44	49	32	24	2	6	0	0.15	0.46
198	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(4), ATR(17), CCNA1(6), CCNE1(3), CDC25A(2), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), DHFR(1), HDAC1(2), RB1(7), SKP2(1), TFDP1(4), TGFB1(1), TGFB2(9)	7411204	68	32	68	19	22	16	17	1	11	1	0.15	0.47
199	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	87	AKT1(2), AKT2(6), AKT3(1), BCL10(3), CARD11(9), CBL(5), CBLB(8), CD247(2), CD28(2), CD3D(1), CD3G(2), CD4(2), CD40LG(6), CD8B(2), CDC42(1), CDK4(3), CHUK(6), CTLA4(2), FOS(1), FYN(5), GRAP2(5), GRB2(3), ICOS(1), IFNG(1), IKBKB(4), IL10(2), IL2(4), IL4(3), LAT(1), LCK(3), LCP2(3), MALT1(7), MAP3K14(3), MAP3K8(2), NCK1(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDK1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCQ(5), PTPN6(4), PTPRC(17), RASGRP1(5), RHOA(5), SOS1(7), SOS2(11), TEC(3), VAV1(13), VAV2(4), VAV3(12), ZAP70(4)	32242472	303	79	300	101	119	103	49	2	30	0	0.15	0.47
200	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(2), GOT1(6), GOT2(1), LDHA(2), LDHB(3), LDHC(2)	2260944	22	15	21	4	9	7	3	0	3	0	0.15	0.47
201	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	CRKL(2), GNAQ(4), GRB2(3), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), PAK1(5), PLCG1(4), PRKCA(4), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), SRC(3), SYT1(1)	9362552	77	38	75	24	20	27	17	4	9	0	0.15	0.47
202	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(4), CSK(3), GRB2(3), PRKCA(4), PTPRA(2), SRC(3)	3135504	28	23	28	9	7	14	6	1	0	0	0.16	0.49
203	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(25), EP300(15), FYN(5), IL7(2), IL7R(3), JAK1(4), JAK3(8), LCK(3), NMI(2), PTK2B(1), STAT5B(3)	8250864	72	35	71	25	24	24	13	1	10	0	0.16	0.49
204	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(2), BLVRB(2), CP(6), CPOX(1), EPRS(12), FECH(3), GUSB(2), HCCS(3), HMBS(2), HMOX1(2), HMOX2(3), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3), UROD(1), UROS(1)	8767900	68	36	67	19	22	27	12	0	7	0	0.16	0.49
205	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(9), HDC(8), TPH1(3)	1993740	25	19	25	8	9	12	3	0	1	0	0.16	0.49
206	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(25), EP300(15), NCOA3(11), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RXRA(1)	6877044	68	35	68	16	21	22	15	2	8	0	0.17	0.50
207	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(3), EPHB2(8), F2(3), F2RL1(1), F2RL2(3), MAP2K5(4), MAPK1(2), MAPK7(3), MAPK8(7), MYEF2(7), PLD1(11), PLD2(2), PLD3(5), PTK2(5), RAF1(6), RASAL1(2), SRC(3), TEC(3), VAV1(13)	9394616	98	43	96	30	46	30	15	1	6	0	0.17	0.50
208	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(4), FUT2(1), FUT9(5), GLA(4), HEXB(3), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST8SIA1(3)	3348292	28	19	28	11	9	7	7	0	5	0	0.17	0.50
209	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	20	COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A6(15), F10(1), F11(4), F12(2), F2(3), F5(21), F8(18), F9(6), FGB(2), FGG(4), KLKB1(6), PROC(1), PROS1(6), SERPINC1(3), SERPING1(5)	13400776	129	44	125	35	27	54	26	1	21	0	0.17	0.50
210	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMB8(3), PSMB9(4)	2851344	23	18	23	6	6	7	5	2	3	0	0.17	0.50
211	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(4), DRD1(1), DRD2(5), GRM1(12), PLCB1(8), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	5320056	49	32	49	19	22	10	8	2	7	0	0.17	0.50
212	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), ACTR3(3), AKT1(2), AKT2(6), AKT3(1), ANGPTL2(8), ARHGAP4(1), ARHGEF11(11), BTK(7), CDC42(1), CFL1(1), GDI1(1), GDI2(1), INPPL1(4), ITPR1(19), ITPR2(18), ITPR3(12), LIMK1(5), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDK1(2), PIK3CD(3), PIK3CG(14), PITX2(2), PPP1R13B(6), RACGAP1(2), RHO(3), ROCK1(15), ROCK2(6), RPS4X(2), SAG(1), WASF1(3), WASL(7)	22408056	207	66	207	60	77	68	33	1	27	1	0.17	0.50
213	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(7), FOS(1), GRB2(3), IL3(3), JAK2(9), MAP2K1(4), MAPK3(3), PTPN6(4), RAF1(6), SHC1(3), SOS1(7), STAT5B(3)	5724296	53	28	50	11	20	16	9	0	6	2	0.18	0.50
214	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CDC42(1), CHUK(6), MAP2K1(4), MAPK3(3), NFKB1(6), RAF1(6), RALA(1), RALBP1(6), RALGDS(1), RELA(2), RHOA(5)	5232176	47	28	46	11	23	5	13	0	6	0	0.18	0.50
215	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CAPN2(6), CAPNS1(1), CAPNS2(1), EP300(15), HDAC1(2), HDAC2(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), SYT1(1)	8018748	63	35	63	17	27	13	11	1	11	0	0.18	0.50
216	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(1), HADHA(3), HADHB(2), HSD17B10(2), HSD17B4(3), MECR(1), PPT2(2)	2848532	17	14	17	9	3	5	2	0	7	0	0.18	0.50
217	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(4), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAPK3(3), MPL(2), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), STAT1(6), STAT3(2), STAT5B(3), THPO(2)	8850108	72	33	70	19	21	26	15	0	8	2	0.18	0.50
218	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(9), AP2A1(3), AP2M1(4), BIN1(2), DNM1(11), EPN1(2), EPS15(7), PICALM(2), PPP3CA(3), PPP3CB(5), PPP3CC(4), SYNJ1(11), SYNJ2(6), SYT1(1)	7621532	70	30	67	25	22	22	10	0	16	0	0.18	0.50
219	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(24), ASH2L(2), C17orf79(1), CARM1(2), CTCFL(8), DOT1L(3), EED(2), EHMT1(2), EHMT2(3), EZH1(5), EZH2(4), FBXO11(5), HSF4(1), JMJD6(2), KDM6A(1), MEN1(2), MLL(21), MLL2(17), MLL3(16), MLL4(11), MLL5(17), NSD1(14), OGT(5), PAXIP1(6), PPP1CB(2), PPP1CC(2), PRDM2(15), PRDM7(2), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), RBBP5(2), SATB1(2), SETD1A(8), SETD2(16), SETD7(3), SETD8(2), SETDB1(8), SETDB2(3), SETMAR(1), SMYD3(4), STK38(2), SUV39H1(1), SUV39H2(3), SUV420H1(8), SUZ12(3), WHSC1(7), WHSC1L1(4)	40128544	283	72	280	81	106	74	55	2	44	2	0.18	0.50
220	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(5), ADSL(7), ADSS(2), AGXT2(5), ASL(2), ASNS(1), ASPA(5), CAD(11), CRAT(3), DARS(4), DDO(2), GAD1(9), GAD2(4), GOT1(6), GOT2(1), GPT2(2), NARS(3), PC(6)	8800792	83	44	82	29	38	30	10	0	5	0	0.18	0.50
221	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(6), LARS(5), LARS2(3), PDHA1(5), PDHA2(8), PDHB(2)	3376212	30	19	29	7	11	9	6	0	4	0	0.18	0.50
222	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(6), SPCS1(1), SPCS3(1)	1054048	10	9	8	3	6	1	1	0	2	0	0.18	0.50
223	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(5), ACTN2(8), ACTN3(3), CSK(3), CTNNA1(12), CTNNA2(12), PECAM1(2), PTK2(5), SRC(3), VCL(2)	6312012	55	35	55	24	31	14	4	1	5	0	0.18	0.50
224	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), AKT2(6), AKT3(1), BPNT1(1), GRB2(3), MAPK1(2), MAPK3(3), PDK1(2), PIK3CD(3), PTK2B(1), RBL2(8), SHC1(3), SOS1(7)	5844760	42	26	41	14	11	13	10	0	8	0	0.18	0.50
225	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), XDH(7)	2686328	28	18	28	12	7	11	6	0	4	0	0.18	0.50
226	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(2), CCNE1(3), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN1B(3), MAPK1(2), MAPK3(3), NFKB1(6), PAK1(5), RAF1(6), RB1(7), RELA(2), TFDP1(4)	5625708	50	28	49	12	18	9	13	2	7	1	0.19	0.53
227	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), NCK1(1), NCKAP1(9), NTRK1(6), PIR(1), PSMA7(1), WASF1(3), WASF2(2), WASF3(4), WASL(7)	5208456	52	29	52	11	17	17	12	0	6	0	0.19	0.53
228	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CDS1(2), CDS2(4), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPP5B(1), INPP5D(4), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), OCRL(9), PI4KA(15), PI4KB(2), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3C3(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PRKCA(4), PRKCG(10), PTPMT1(2), SYNJ1(11), SYNJ2(6)	41244280	335	91	330	101	141	95	60	2	36	1	0.20	0.53
229	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(4), LIPT1(4)	512736	8	6	8	1	0	6	1	0	1	0	0.20	0.53
230	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(3), ENO3(4), FARS2(5), GOT1(6), GOT2(1), PAH(4), TAT(5), YARS(2)	2781724	30	19	29	7	8	11	6	0	5	0	0.20	0.53
231	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(1), ANXA2(2), ANXA3(1), ANXA4(4), ANXA5(1), ANXA6(3), CYP11A1(4), EDN1(1), EDNRA(4), HSD11B1(1), PLA2G4A(8), PRL(3), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	6621316	62	31	61	13	26	20	10	0	6	0	0.20	0.53
232	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(2), CDKN1B(3), GRB2(3), ITGB1(6), MAPK1(2), MAPK3(3), PDK2(2), PDPK1(1), PTK2(5), SHC1(3), SOS1(7)	4953864	37	25	36	11	6	13	11	0	7	0	0.20	0.54
233	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(1), UGDH(4), UXS1(7)	1358528	15	12	15	4	5	6	2	0	2	0	0.20	0.54
234	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(4), ANAPC10(2), ANAPC2(1), ANAPC4(4), ANAPC5(3), ANAPC7(4), BTRC(5), CDC16(4), CDC20(3), CDC23(6), CUL1(8), CUL2(5), CUL3(1), FBXW11(8), ITCH(3), RBX1(1), SKP1(1), SKP2(1), SMURF1(3), SMURF2(2), UBA1(2), UBE2C(2), UBE2D1(1), UBE2D3(1), UBE2D4(1), UBE2E1(3), UBE2E2(1), VHL(1), WWP1(8), WWP2(4)	12536056	93	44	92	34	28	34	17	0	14	0	0.21	0.54
235	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), GNAQ(4), MARCKS(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), SP1(2), SP3(3), SYT1(1)	6903604	49	33	49	17	22	11	5	0	11	0	0.21	0.54
236	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(25), EP300(15), LPL(6), NCOA1(8), NCOA2(7), PPARG(1), RXRA(1)	6220160	63	30	63	20	19	19	17	1	7	0	0.21	0.54
237	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	43	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2(1), BCR(7), BLNK(1), BTK(7), CD19(3), CD22(10), CR2(11), CSK(3), DAG1(5), FLOT1(3), GRB2(3), GSK3A(2), INPP5D(4), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), MAP4K1(3), MAPK1(2), MAPK3(3), NFATC1(2), NFATC2(5), PDK1(2), PIK3CD(3), PLCG2(13), PPP1R13B(6), PPP3CA(3), PPP3CB(5), PPP3CC(4), PTPRC(17), RAF1(6), SHC1(3), SOS1(7), SOS2(11), SYK(3), VAV1(13)	23352160	234	66	229	57	91	74	36	2	30	1	0.21	0.55
238	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(4), ACO2(2), CLYBL(6), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), OGDHL(11), PC(6), PCK1(3), PCK2(3), SDHA(6), SDHB(2), SDHD(1), SUCLA2(5), SUCLG1(2)	10087580	80	46	79	30	31	24	16	1	8	0	0.21	0.55
239	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PCYT1A(5), PCYT1B(5), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), WBSCR22(1)	4760052	43	28	42	16	12	14	11	2	4	0	0.21	0.55
240	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(3), GH1(2), GHR(6), IGF1(2), IGF1R(8), SHC1(3), SOD2(4)	3192880	30	24	29	13	14	9	5	0	2	0	0.22	0.55
241	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	68	AKT1(2), AKT2(6), AKT3(1), BTK(7), FCER1A(3), FYN(5), GAB2(1), GRB2(3), IL13(1), IL3(3), IL4(3), INPP5D(4), LAT(1), LCP2(3), LYN(4), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(5), MS4A2(3), PDK1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCG1(4), PLCG2(13), PRKCA(4), PRKCD(3), PRKCE(6), RAF1(6), SOS1(7), SOS2(11), SYK(3), VAV1(13), VAV2(4), VAV3(12)	22174012	214	66	207	59	84	63	43	3	21	0	0.22	0.56
242	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	94	AKT1(2), AKT2(6), AKT3(1), CD14(1), CD40(1), CD80(1), CHUK(6), CXCL10(1), CXCL11(3), CXCL9(3), FOS(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IKBKB(4), IKBKE(4), IL12A(1), IL12B(2), IL1B(1), IL6(2), IL8(1), IRAK1(1), IRAK4(4), IRF3(2), IRF5(3), LBP(1), LY96(2), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K7(4), MAP3K8(2), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(5), MYD88(2), NFKB1(6), NFKB2(4), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), RELA(2), RIPK1(2), SPP1(1), STAT1(6), TBK1(6), TICAM1(2), TIRAP(1), TLR1(5), TLR2(6), TLR3(5), TLR4(10), TLR5(4), TLR6(2), TLR7(7), TLR8(6), TLR9(7), TOLLIP(1), TRAF3(6), TRAF6(4)	27922384	246	66	246	72	69	89	57	4	26	1	0.22	0.57
243	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(1), ALAS1(6), ALAS2(6), BLVRA(2), BLVRB(2), COX10(2), COX15(3), CP(6), CPOX(1), EPRS(12), FECH(3), FTMT(4), GUSB(2), HCCS(3), HMBS(2), HMOX1(2), HMOX2(3), MMAB(2), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), UROD(1), UROS(1)	13150796	121	45	119	27	33	56	22	0	10	0	0.23	0.57
244	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(3), CBS(3), CTH(2), MUT(4)	1640048	13	11	13	1	5	4	0	0	4	0	0.23	0.57
245	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5R1(1), EGR1(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(3), RAF1(6)	2576256	23	17	22	6	9	4	6	0	4	0	0.23	0.57
246	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(4), BAIAP2(1), CASP1(2), CASP3(2), CASP7(1), INSR(6), ITCH(3), MAGI1(13), MAGI2(11), RERE(3), WWP1(8), WWP2(4)	7534216	58	37	57	22	20	19	10	0	9	0	0.23	0.57
247	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), CDC42(1), PAK1(5), PDGFRA(17), WASL(7)	3258184	44	17	44	14	12	13	10	1	7	1	0.23	0.57
248	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	62	ADAM10(1), ADAM17(7), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), CASP3(2), CDC42(1), CHUK(6), CSK(3), EGFR(11), F11R(1), GIT1(3), HBEGF(1), IGSF5(8), IKBKB(4), IL8(1), JAM3(3), LYN(4), MAP3K14(3), MAPK12(2), MAPK13(1), MAPK14(3), MAPK8(7), MAPK9(5), MET(5), NFKB1(6), NFKB2(4), NOD1(4), PAK1(5), PLCG1(4), PLCG2(13), PTPN11(5), PTPRZ1(17), RELA(2), SRC(3), TCIRG1(2), TJP1(7)	23005996	195	63	192	50	72	59	42	2	19	1	0.23	0.57
249	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(2), AGPAT1(2), AGPAT3(3), AGPAT6(2), CDS1(2), CDS2(4), CHAT(6), CHKA(4), CHPT1(1), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), ESCO1(11), ESCO2(4), ETNK1(2), ETNK2(2), GNPAT(2), GPAM(3), GPD1(1), GPD1L(3), GPD2(4), LCAT(1), MYST3(18), MYST4(10), PCYT1A(5), PCYT1B(5), PEMT(1), PISD(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLD1(11), PLD2(2), PNPLA3(4), PPAP2B(1), PTDSS1(7), SH3GLB1(4)	22038864	194	64	192	71	68	66	43	1	16	0	0.23	0.57
250	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(2), B3GALNT1(4), B3GALT1(1), B3GALT2(3), B3GALT4(1), B3GALT5(4), B3GNT1(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALNT1(4), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT6(5), FUT1(4), FUT2(1), FUT3(4), FUT6(1), FUT9(5), GCNT2(11), PIGA(1), PIGB(2), PIGG(3), PIGK(4), PIGM(3), PIGN(2), PIGO(3), PIGQ(1), PIGS(2), PIGT(3), PIGU(1), PIGV(2), PIGX(4), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST3GAL6(7), ST6GALNAC3(4), ST6GALNAC4(2), ST6GALNAC5(6), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(6), UGCG(2)	16392716	148	50	147	44	57	42	29	1	19	0	0.23	0.57
251	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(3), HBXIP(2), PTK2B(1), SHC1(3), SOS1(7), SRC(3)	2968856	20	17	19	7	2	10	5	0	3	0	0.23	0.57
252	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH7A1(3), ALDH9A1(1), AMDHD1(4), AOC2(4), AOC3(4), ASPA(5), CARM1(2), CNDP1(3), DDC(1), FTCD(2), HAL(4), HARS(2), HARS2(4), HDC(8), HNMT(4), LCMT1(3), LCMT2(2), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), PRPS1(1), PRPS2(2), UROC1(3), WBSCR22(1)	13338664	118	52	116	43	43	41	23	2	9	0	0.24	0.57
253	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(6), IARS2(6), ILVBL(2), LARS(5), LARS2(3), PDHA1(5), PDHA2(8), PDHB(2), VARS(1), VARS2(6)	5917736	46	29	45	14	20	12	8	0	6	0	0.24	0.58
254	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(2), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), PC(6), PCK1(3), SDHA(6), SDHB(2), SUCLA2(5), SUCLG1(2)	6978460	51	34	51	22	20	17	7	0	7	0	0.24	0.58
255	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(6), CARS2(1), CDO1(1), CTH(2), GOT1(6), GOT2(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), SDS(2), SULT1B1(4), SULT1C2(2), SULT4A1(1)	4004612	38	21	37	7	14	14	6	0	4	0	0.24	0.58
256	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(9), AGT(5), AGTR2(5), EDN1(1), EDNRA(4), EGF(3), EGFR(11), FOS(1), NFKB1(6), PLCG1(4), PRKCA(4), RELA(2)	6592856	55	33	55	15	25	15	10	0	5	0	0.24	0.58
257	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(6), CREBBP(25), EP300(15), HDAC3(2), IKBKB(4), NFKB1(6), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF6(4)	7527600	68	34	68	21	26	18	16	1	7	0	0.24	0.58
258	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(11), ABCB11(11), ABCB4(11), ABCC1(11), ABCC3(5)	4897596	49	26	49	13	9	18	14	1	7	0	0.24	0.58
259	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(6), EPHB1(9), FYN(5), ITGA1(3), ITGB1(6), L1CAM(4), LYN(4), RAP1B(2), SELP(6)	5303624	49	28	48	14	19	18	8	0	4	0	0.24	0.58
260	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(5)	724256	7	7	7	3	3	3	0	0	1	0	0.25	0.58
261	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	43	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), AGPAT1(2), AGPAT3(3), AKR1B1(3), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), CEL(1), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), GK(3), GLA(4), GLB1(3), LCT(20), LIPC(4), LIPF(3), LIPG(2), LPL(6), PNLIP(7), PNLIPRP1(4), PNLIPRP2(2), PPAP2B(1)	15824776	166	51	166	48	53	60	39	0	14	0	0.25	0.58
262	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA1(2), ACAA2(1), ACADM(6), ACAT1(1), ACAT2(2), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH7A1(3), ALDH9A1(1), AOX1(8), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(3), BCKDHB(1), DLD(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(3), HADHB(2), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B10(2), HSD17B4(3), MCCC1(8), MCCC2(2), MCEE(2), MUT(4), OXCT1(3), OXCT2(1), PCCA(9), PCCB(4)	14612196	115	50	114	32	44	39	15	0	17	0	0.25	0.58
263	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(6), GOT2(1), TAT(5), TYR(3)	1578396	16	12	15	7	6	5	3	0	2	0	0.25	0.59
264	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1), TPK1(3)	2155772	20	15	20	5	8	6	4	0	2	0	0.26	0.60
265	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(6), PLCB1(8), PRKCA(4), RELA(2)	2786092	24	16	24	9	10	6	3	1	4	0	0.26	0.60
266	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(5), MMP9(11), RECK(5), TIMP1(2), TIMP2(2), TIMP3(3), TIMP4(2)	2546160	34	22	34	8	19	7	7	0	1	0	0.26	0.60
267	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(4), ATG7(1), BECN1(3), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNG(1), PIK3C3(7), PIK3R4(12), PRKAA1(3), PRKAA2(9), ULK1(1), ULK2(4), ULK3(3)	7033388	72	32	71	17	14	32	20	0	6	0	0.26	0.60
268	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA13(1), CA14(2), CA2(1), CA3(2), CA4(1), CA5A(2), CA6(2), CA8(3), CA9(2), CPS1(14), CTH(2), GLS2(2), GLUD1(2), GLUD2(6), GLUL(4), HAL(4)	7083264	52	30	52	26	20	17	6	0	9	0	0.26	0.60
269	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), MIOX(1), UGDH(4)	2871660	31	20	31	6	10	12	5	0	4	0	0.27	0.60
270	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT1(2), AKT3(1), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(6), CAPN3(6), CAPN5(5), CAPN6(3), CAPN7(4), CAPN9(1), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(1), CSK(3), DOCK1(7), FYN(5), GIT2(7), GRB2(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAD(8), ITGAE(7), ITGAL(8), ITGAM(8), ITGAV(5), ITGAX(6), ITGB1(6), ITGB2(5), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAPK12(2), MAPK4(1), MAPK6(3), MAPK7(3), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(5), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(15), ROCK2(6), SEPP1(1), SHC1(3), SHC3(1), SORBS1(11), SOS1(7), SRC(3), TLN1(7), TNS1(14), VASP(3), VAV2(4), VAV3(12), VCL(2), ZYX(1)	45612860	365	95	357	136	126	125	63	9	42	0	0.27	0.60
271	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(3), ALDH5A1(4), CAD(11), CPS1(14), EPRS(12), GAD1(9), GAD2(4), GCLC(4), GCLM(1), GFPT1(4), GLS2(2), GLUD1(2), GLUL(4), GMPS(5), GOT1(6), GOT2(1), GPT2(2), GSS(4), NADSYN1(2), PPAT(6), QARS(8)	11133376	113	44	112	23	36	39	26	2	10	0	0.27	0.60
272	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(4), GPR161(7), GPR171(4), GPR18(2), GPR34(6), GPR39(3), GPR45(7), GPR65(1), GPR75(2)	3322532	39	23	39	12	17	9	8	0	5	0	0.27	0.60
273	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(9), EGF(3), EGFR(11), TF(11), TFRC(3)	4321724	37	23	37	7	17	9	7	0	3	1	0.27	0.60
274	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(8), POLA2(2), POLB(3), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLG(5), POLG2(1), POLH(5), POLI(10), POLK(3), POLL(1), POLM(2), POLQ(12), REV1(7), REV3L(22), RFC5(3)	13771996	115	42	110	34	30	46	23	0	14	2	0.27	0.61
275	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCR(7), BLNK(1), BTK(7), CD19(3), CSK(3), DAG1(5), EPHB2(8), GRB2(3), ITPKB(4), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PI3(1), PIK3CD(3), PLCG2(13), PPP1R13B(6), RAF1(6), SERPINA4(5), SHC1(3), SOS1(7), SOS2(11), SYK(3), VAV1(13)	16282968	151	58	146	39	63	43	29	2	14	0	0.27	0.61
276	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(4), GLB1(3), HEXB(3), LCT(20), SLC33A1(2), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(4), ST6GALNAC4(2), ST6GALNAC5(6), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(6)	5547116	59	31	58	20	27	16	11	0	5	0	0.27	0.61
277	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BNIP1(1), GOSR1(3), GOSR2(3), SEC22B(3), SNAP23(1), SNAP25(1), SNAP29(3), STX11(2), STX12(3), STX16(3), STX17(1), STX18(1), STX19(2), STX2(3), STX3(3), STX4(2), STX5(3), STX6(1), STX7(3), STX8(4), TSNARE1(1), VAMP1(1), VAMP3(2), VAMP4(3), VAMP5(2), VAMP8(1), VTI1A(1), VTI1B(1), YKT6(1)	5513852	60	26	58	17	23	14	9	0	14	0	0.28	0.61
278	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(2), GLUD1(2), GLUD2(6)	1449628	10	10	10	6	6	3	1	0	0	0	0.28	0.62
279	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	9	AKT1(2), GRB2(3), NTRK1(6), PLCG1(4), PRKCA(4), SHC1(3), SOS1(7)	3814532	29	23	28	9	6	13	7	0	3	0	0.28	0.62
280	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	108	ADA(3), ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADK(1), ADSL(7), ADSS(2), AK2(1), AK5(5), ALLC(5), AMPD1(9), AMPD2(5), AMPD3(3), ATIC(4), ATP1B1(1), ATP5A1(5), ATP5B(4), ATP5C1(4), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), DCK(2), ENPP1(4), ENPP3(4), ENTPD1(2), FHIT(1), GART(3), GMPS(5), GUCY1A2(12), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HPRT1(2), IMPDH1(2), IMPDH2(4), ITPA(2), NPR1(6), NPR2(10), NT5E(3), NT5M(1), PAICS(1), PAPSS1(2), PAPSS2(4), PDE1A(4), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE5A(6), PDE6B(5), PDE6C(10), PDE7B(4), PDE8A(1), PDE9A(6), PFAS(1), PKM2(2), POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12), POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1), PPAT(6), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(2), RRM2(2)	42480624	361	90	355	103	127	120	64	2	48	0	0.28	0.62
281	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(5), DNMT1(19), MTNR1B(3), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1)	3740564	39	26	35	8	18	10	7	3	1	0	0.29	0.64
282	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(6), GNB1(1), GNGT1(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4)	3168296	26	22	26	7	11	9	4	0	2	0	0.30	0.64
283	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(6), ACAT1(1), ECHS1(2), HADHA(3)	1824120	14	9	13	5	2	4	1	0	7	0	0.30	0.64
284	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(5), PDHA2(8), PDHB(2), SDHB(2), SDS(2)	8712916	95	41	94	25	36	36	15	0	8	0	0.30	0.65
285	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	28	DUSP1(2), GORASP1(4), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MAPKAPK5(1), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PIK3CD(3), SYT1(1), TRAF2(1), TRAF3(6), TRAF5(6), TRAF6(4)	9242376	68	38	68	25	22	14	14	4	14	0	0.30	0.65
286	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(1), TAT(5)	882876	12	8	11	2	4	5	1	0	2	0	0.30	0.65
287	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMC2(1), PSMC3(3), PSMD1(8), PSMD11(3), PSMD12(4), PSMD13(2), PSMD2(4), PSMD6(3)	5395420	44	25	43	15	15	14	9	2	4	0	0.30	0.65
288	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(25), DAXX(1), PAX3(7), PML(4), RB1(7), SIRT1(5), SP100(4), TNFRSF1A(1)	6122116	54	30	53	22	20	12	14	0	7	1	0.31	0.66
289	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(18), ATP4A(10), ATP4B(1), ATP5A1(5), ATP5B(4), ATP5C1(4), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), ATP5L(2), ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), COX10(2), COX15(3), COX17(1), COX4I1(2), COX4I2(3), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8C(1), CYC1(1), LHPP(2), NDUFA1(1), NDUFA10(2), NDUFA12(2), NDUFA13(1), NDUFA4(2), NDUFA9(3), NDUFB1(1), NDUFB2(1), NDUFB3(1), NDUFB6(1), NDUFB9(2), NDUFC2(1), NDUFS1(6), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(2), NDUFS6(2), NDUFV1(2), NDUFV3(1), PPA1(2), PPA2(3), SDHA(6), SDHB(2), SDHD(1), TCIRG1(2), UQCRB(2), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRH(1)	18698360	172	59	170	44	69	55	33	0	15	0	0.31	0.66
290	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(2), HLA-DRA(5), HLA-DRB1(2), IFNG(1), IFNGR1(3), IFNGR2(2), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL2(4), IL2RA(2), IL4(3), IL4R(1)	3858816	36	19	36	13	13	16	3	0	2	2	0.31	0.66
291	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(6), MAP3K14(3), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), TNFRSF13B(4), TNFRSF17(2), TNFSF13B(1), TRAF2(1), TRAF3(6), TRAF5(6), TRAF6(4)	4805352	51	27	51	15	21	12	9	3	6	0	0.31	0.66
292	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(5), AGTR1(5), AGTR2(5), BDKRB2(3), KNG1(4), NOS3(2), REN(5)	3308712	31	21	30	9	9	10	6	0	6	0	0.31	0.66
293	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	AKR1C3(2), ALOX12(2), ALOX5(4), CYP4F2(8), CYP4F3(3), EPX(7), LPO(3), MPO(5), PLA2G1B(1), PLA2G4A(8), PLA2G6(4), PRDX1(1), PRDX6(2), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5), TPO(11)	9056448	80	42	78	29	42	22	8	2	6	0	0.31	0.66
294	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	124	ACACA(18), ACACB(15), AKT1(2), AKT2(6), AKT3(1), ARAF(3), BAD(1), CBL(5), CBLB(8), CRKL(2), EXOC7(2), FASN(1), FBP2(3), FLOT1(3), FOXO1(1), G6PC(4), G6PC2(1), GCK(2), GRB2(3), GYS1(2), GYS2(11), IKBKB(4), INPP5D(4), INSR(6), IRS1(8), IRS4(15), LIPE(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(7), MAPK9(5), MKNK1(1), MKNK2(3), PCK1(3), PCK2(3), PDE3A(5), PDE3B(3), PDPK1(1), PFKL(1), PFKM(4), PFKP(2), PHKA1(8), PHKA2(6), PHKB(6), PHKG2(3), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PKM2(2), PPARGC1A(5), PPP1CB(2), PPP1CC(2), PPP1R3A(13), PPP1R3B(1), PPP1R3C(4), PPP1R3D(1), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAG3(6), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCI(4), PRKX(2), PTPN1(5), PTPRF(9), PYGB(4), PYGL(2), PYGM(4), RAF1(6), RAPGEF1(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(11), SOS1(7), SOS2(11), SREBF1(1), TSC1(4), TSC2(2)	51106708	401	97	392	154	147	130	75	5	44	0	0.31	0.66
295	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	25	AKT1(2), AKT2(6), AKT3(1), ANKRD6(5), AXIN1(2), AXIN2(9), CER1(3), CSNK1A1(2), DACT1(6), DKK1(5), DKK3(2), FSTL1(6), GSK3A(2), LRP1(17), MVP(4), NKD1(3), NKD2(1), PIN1(1), PSEN1(3), PTPRA(2), SENP2(3), SFRP1(3), TSHB(1), WIF1(2)	10507140	91	46	90	32	39	21	21	0	10	0	0.31	0.66
296	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(14), GLUD1(2), GOT1(6)	2556608	25	14	24	6	6	9	4	0	6	0	0.32	0.66
297	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(2), AP2A1(3), AP2M1(4), BAD(1), BTK(7), EEA1(9), GRASP(1), GSK3A(2), LYN(4), PDPK1(1), PFKL(1), PFKM(4), PFKP(2), PLCG1(4), PRKCE(6), RPS6KB1(3), VAV2(4)	8299376	58	32	58	19	20	19	10	0	8	1	0.32	0.66
298	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(2), CDK7(1), ERCC3(7), GTF2B(1), GTF2E1(5), GTF2F2(1), GTF2H1(4), GTF2H4(1), MNAT1(1), POLR1A(10), POLR1B(8), POLR2A(6), POLR2B(8), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3B(11), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(1), TAF5(4), TAF6(3), TAF7(2), TAF9(1), TBP(1)	11874536	92	44	92	26	33	31	17	1	10	0	0.32	0.66
299	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), NTAN1(3), SIRT1(5), SIRT2(2), SIRT5(3), SIRT7(1), VNN2(2)	3953912	29	21	29	12	9	7	5	0	8	0	0.32	0.66
300	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	45	ACOX1(3), APOA2(1), CD36(1), CITED2(1), CPT1B(5), CREBBP(25), DUSP1(2), EHHADH(2), EP300(15), FABP1(1), HSD17B4(3), LPL(6), MAPK1(2), MAPK3(3), NCOA1(8), NCOR1(12), NCOR2(2), NR1H3(4), NR2F1(3), NRIP1(6), PDGFA(1), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PTGS2(3), RB1(7), RELA(2), RXRA(1), SP1(2), STAT5B(3)	19236808	142	51	142	52	45	43	32	2	19	1	0.32	0.66
301	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(7), PRKCA(4), TGM2(6)	1700380	22	14	22	6	9	11	1	0	1	0	0.32	0.66
302	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(8), GNAS(6), PLCE1(9), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RAP2B(1)	4839720	37	27	37	11	15	12	6	0	4	0	0.32	0.66
303	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3D(1), CD3G(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	3589836	40	21	40	14	9	16	7	0	8	0	0.33	0.66
304	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(13), PPP1R1B(1)	1277456	16	13	15	5	7	3	5	0	1	0	0.33	0.66
305	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS1(1), DHRS2(3), DHRS3(2), HSD3B7(2), PON1(6), PON2(2), PON3(2), RDH11(1), RDH12(3), RDH13(1)	2836156	23	18	23	10	10	7	2	0	4	0	0.33	0.66
306	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	78	AGL(9), AMY2B(1), ASCC3(19), ATP13A2(3), DDX18(3), DDX19A(3), DDX23(4), DDX4(3), DDX41(2), DDX47(3), DDX50(3), DDX52(2), DDX54(5), DDX55(3), DDX56(5), DHX58(3), ENPP1(4), ENPP3(4), ENTPD7(4), EP400(20), ERCC2(4), ERCC3(7), G6PC(4), G6PC2(1), GANC(3), GBA3(3), GBE1(5), GCK(2), GPI(2), GUSB(2), GYS1(2), GYS2(11), HK1(6), HK2(3), HK3(5), IFIH1(5), MGAM(13), MOV10L1(13), PGM1(4), PGM3(5), PYGB(4), PYGL(2), PYGM(4), RAD54B(8), RAD54L(3), RUVBL2(1), SETX(20), SI(15), SKIV2L2(3), SMARCA2(10), SMARCA5(7), TREH(2), UGDH(4), UGP2(7), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), UXS1(7)	40950984	354	82	351	101	117	112	78	0	46	1	0.33	0.66
307	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR7(3), CD28(2), CD4(2), CXCR4(4), IFNG(1), IFNGR1(3), IFNGR2(2), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL2(4), IL4(3), IL4R(1), TGFB1(1), TGFB2(9)	6202380	57	29	58	29	15	30	6	0	6	0	0.33	0.66
308	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	3	EGF(3), EGFR(11), UBE2D1(1)	1823024	15	14	15	4	9	2	3	0	1	0	0.33	0.66
309	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	26	ABAT(5), ABP1(1), ACADL(2), ACADM(6), ACADSB(5), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYS(7), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), MLYCD(1), SDS(2), SMS(2), UPB1(5)	9046744	100	40	99	24	37	35	16	1	11	0	0.33	0.66
310	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(5), IGF1(2), IL11(1), IL1A(1), IL3(3), IL6(2), IL9(2), KITLG(2), TGFB1(1), TGFB2(9)	2857640	28	18	27	13	9	11	4	0	4	0	0.33	0.66
311	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(6), ABAT(5), ADSL(7), ADSS(2), AGXT2(5), ASL(2), ASNS(1), ASPA(5), ASS1(2), CAD(11), CRAT(3), DARS(4), DARS2(3), DDO(2), DLAT(3), DLD(1), GAD1(9), GAD2(4), GOT1(6), GOT2(1), GPT2(2), NARS(3), NARS2(6), PC(6), PDHA1(5), PDHA2(8), PDHB(2)	12804920	119	50	117	38	53	38	17	0	11	0	0.34	0.67
312	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	533176	5	5	5	0	0	2	3	0	0	0	0.34	0.67
313	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3D(1), CD3G(2), CD4(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	3788088	42	22	42	16	9	18	7	0	8	0	0.34	0.67
314	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(2), ALOX12B(2), ALOX15B(5), ALOX5(4), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2J2(3), CYP2U1(1), CYP4A11(3), CYP4A22(2), CYP4F2(8), CYP4F3(3), EPHX2(1), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GPX6(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	12888908	105	50	104	37	41	36	19	2	7	0	0.34	0.67
315	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(1), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(7), GOT1(6), GOT2(1), HPD(4), LPO(3), MAOA(3), MAOB(1), MPO(5), PRDX1(1), PRDX6(2), TAT(5), TPO(11)	7429544	71	41	69	26	35	22	8	0	6	0	0.34	0.67
316	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	73	ABL1(4), ACTN1(5), ACTR2(2), ACTR3(3), AKT1(2), AKT2(6), AKT3(1), ANGPTL2(8), ARHGEF6(10), ARHGEF7(8), CAV1(1), CDC42(1), CDKN2A(1), CSE1L(4), DOCK1(7), EPHB2(8), FYN(5), GRB2(3), GRB7(1), GRLF1(12), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGB3BP(3), MAP3K11(4), MAPK1(2), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MRAS(1), MYLK(14), MYLK2(3), P4HB(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PIK3CB(2), PLCG1(4), PLCG2(13), PTK2(5), RAF1(6), RALA(1), RHO(3), ROCK1(15), ROCK2(6), SHC1(3), SOS1(7), SOS2(11), SRC(3), TERF2IP(2), TLN1(7), TLN2(8), VASP(3), WAS(1), ZYX(1)	39349620	322	86	313	125	117	100	55	5	45	0	0.34	0.67
317	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), GOT1(6), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME3(5), PGK1(3), PGK2(7), PKM2(2), RPE(2), RPIA(3), TKT(3), TKTL1(5), TKTL2(7), TPI1(1)	6247096	61	34	60	24	21	26	9	0	5	0	0.35	0.67
318	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	57	AKT1(2), AKT2(6), AKT3(1), BCL10(3), BLNK(1), BTK(7), CARD11(9), CD19(3), CD22(10), CD72(4), CD79A(3), CD79B(1), CHUK(6), CR2(11), FOS(1), IFITM1(1), IKBKB(4), INPP5D(4), LILRB3(2), LYN(4), MALT1(7), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(7), SYK(3), VAV1(13), VAV2(4), VAV3(12)	23232368	220	67	215	62	98	69	31	1	21	0	0.35	0.67
319	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	4	GBA3(3), SHMT1(2), SHMT2(2)	1097828	7	7	7	4	2	2	0	0	3	0	0.35	0.67
320	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(3), CDKN2A(1), CFL1(1), E2F2(1), MDM2(4), NXT1(1), PRB1(1)	2416612	18	14	18	5	3	4	6	1	4	0	0.35	0.67
321	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(2), BAD(1), CHRNB1(3), CHRNG(3), MUSK(4), PTK2(5), PTK2B(1), RAPSN(2), SRC(3), TERT(2), YWHAH(1)	4371248	27	22	27	16	10	7	2	1	7	0	0.35	0.67
322	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), IL11(1), IL2(4), IL3(3), IL4(3), IL6(2), IL7(2), IL8(1), IL9(2)	2111556	22	14	21	8	9	10	2	0	1	0	0.35	0.67
323	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(8), BAX(1), BCL2(1), CCNE1(3), CDK2(2), CDK4(3), CDKN1A(1), MDM2(4), PCNA(3), RB1(7), TIMP3(3)	3794024	36	21	36	9	9	12	10	1	3	1	0.35	0.67
324	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(5), AGTR1(5), ATF2(1), EGFR(11), GNAQ(4), GRB2(3), MAP2K1(4), MAP2K2(1), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), MEF2A(4), MEF2C(9), MEF2D(1), PAK1(5), PRKCA(4), PTK2(5), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), SRC(3), SYT1(1)	11220428	103	41	101	29	31	35	22	2	13	0	0.35	0.67
325	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATR(17), CDC25C(4), CHEK1(1), CHEK2(1), YWHAH(1)	2983932	24	15	24	4	9	10	2	0	3	0	0.35	0.67
326	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL12A(1), IL12B(2), IL13(1), IL15(1), IL16(9), IL1A(1), IL2(4), IL3(3), IL4(3), IL6(2), IL8(1), IL9(2)	3264776	35	20	34	20	13	17	3	0	2	0	0.36	0.68
327	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(3), DHRS3(2), ESCO1(11), ESCO2(4), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4)	5363104	57	27	56	17	24	14	13	1	5	0	0.36	0.68
328	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(8), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIK(1), BIRC2(4), BIRC3(7), CASP3(2), CASP6(2), CASP7(1), CASP9(2), DFFA(3), DFFB(2), DIABLO(1)	4202528	38	24	38	9	11	15	7	0	5	0	0.37	0.69
329	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(5), GPD2(4), NDUFA1(1), SDHA(6), SDHB(2), SDHD(1), UQCRC1(2)	2201480	21	15	21	3	6	11	3	0	1	0	0.38	0.70
330	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(8), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(6), GRB2(3), MAPK1(2), MAPK14(3), MAPK3(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), RPS6KA1(1), RPS6KA5(6), SOS1(7)	8480868	67	39	66	23	25	23	16	0	3	0	0.38	0.70
331	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(4), IFNG(1), IFNGR1(3), IFNGR2(2), IKBKB(4), JAK2(9), LIN7A(2), NFKB1(6), RB1(7), RELA(2), TNFRSF1A(1), USH1C(8), WT1(6)	5834372	55	25	55	18	18	18	9	0	7	3	0.38	0.71
332	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(1), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(7), ESCO1(11), ESCO2(4), GOT1(6), GOT2(1), HPD(4), LPO(3), MAOA(3), MAOB(1), MPO(5), MYST3(18), MYST4(10), PNPLA3(4), PRDX6(2), SH3GLB1(4), TAT(5), TPO(11)	11521728	121	49	118	38	55	36	21	1	8	0	0.38	0.71
333	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(2), AKT2(6), AKT3(1), ARHGEF11(11), BCL2(1), CDC42(1), DLG4(3), GNA13(2), LPA(10), MAP3K1(8), MAP3K5(6), MAPK8(7), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(6), PI3(1), PIK3CB(2), PLD1(11), PLD2(2), PLD3(5), PTK2(5), RDX(3), ROCK1(15), ROCK2(6), SERPINA4(5), SRF(3)	16188040	137	48	137	44	56	40	21	3	17	0	0.38	0.71
334	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(9), JAK3(8), MAPK1(2), MAPK3(3), STAT3(2), TYK2(1)	4021052	29	20	28	10	9	9	4	0	5	2	0.39	0.71
335	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(5), HDAC9(13), MEF2A(4), MEF2C(9), MEF2D(1), YWHAH(1)	2816904	36	18	36	15	9	14	10	0	3	0	0.39	0.71
336	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(1), RANBP2(16), RANGAP1(1)	2797624	20	12	19	4	5	5	6	0	4	0	0.39	0.71
337	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(2), AKT2(6), AKT3(1), ASAH1(3), DAG1(5), DRD2(5), EGFR(11), EPHB2(8), GRB2(3), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), PI3(1), PIK3CB(2), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), RAF1(6), RGS20(4), SHC1(3), SOS1(7), SOS2(11), SRC(3), STAT3(2), TERF2IP(2)	19468504	180	61	177	54	76	56	31	1	15	1	0.39	0.71
338	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	25	AHCY(3), CARM1(2), CBS(3), CTH(2), LCMT1(3), LCMT2(2), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), METTL2B(2), METTL6(8), PAPSS1(2), PAPSS2(4), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SCLY(1), SEPHS1(3), SEPHS2(3), WBSCR22(1)	8020396	68	36	66	21	23	24	12	2	7	0	0.39	0.72
339	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), CKM(5), FBL(3), LDHA(2), LDHB(3), LDHC(2), MAPK14(3), NCL(3)	2992944	29	21	29	14	12	12	4	0	1	0	0.40	0.72
340	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(6), DAXX(1), EGF(3), EGFR(11), ETS1(1), ETS2(3), FOS(1), HOXA7(1), IKBKB(4), MAP2K1(4), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K5(6), MAPK1(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), NFKB1(6), PPP2CA(1), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), RAF1(6), RELA(2), RIPK1(2), SP1(2), TNFRSF1A(1), TRAF2(1)	16316384	130	58	129	41	58	34	30	3	5	0	0.40	0.72
341	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CLCA1(6), CLCA2(7), CLCA4(6), CNGA3(6), CNGA4(6), CNGB1(7), GNAL(4), GUCA1A(2), GUCA1B(3), GUCA1C(1), PDC(2), PDE1C(9), PRKACA(1), PRKACB(1), PRKACG(3), PRKG1(9), PRKG2(5), PRKX(2)	10394224	92	38	90	41	28	38	15	1	10	0	0.40	0.72
342	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(2), RPE(2), UCHL1(2), UCHL3(2), UGDH(4), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3)	5467492	39	22	39	11	15	14	3	0	7	0	0.40	0.72
343	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(4), EGF(3), EGFR(11), FOS(1), GRB2(3), JAK1(4), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3), STAT1(6), STAT3(2)	11109064	92	41	89	23	34	28	22	1	7	0	0.41	0.72
344	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(4), IL13(1), IL4(3), MAF(1), MAP2K3(6), MAPK14(3), NFATC1(2), NFATC2(5), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	3873292	38	26	38	11	21	8	4	2	3	0	0.41	0.72
345	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(2), DHRS1(1), DHRS2(3), DHRS3(2), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), WBSCR22(1)	4834036	38	24	37	15	13	10	7	2	6	0	0.41	0.72
346	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(4), CRKL(2), DOCK1(7), FOS(1), GAB1(6), GRB2(3), HGF(8), ITGA1(3), ITGB1(6), MAP2K1(4), MAP2K2(1), MAP4K1(3), MAPK1(2), MAPK3(3), MAPK8(7), MET(5), PAK1(5), PTK2(5), PTK2B(1), PTPN11(5), RAF1(6), RAP1A(2), RAP1B(2), RASA1(9), SOS1(7), SRC(3), STAT3(2)	13708104	112	44	109	30	30	43	27	2	10	0	0.41	0.72
347	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(5), ASL(2), ASS1(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), DAO(6), EPRS(12), GAMT(1), GATM(1), GLUD1(2), GLUD2(6), GOT1(6), GOT2(1), LAP3(2), NOS1(11), NOS3(2), OAT(1), OTC(5), P4HA1(1), P4HA2(2), P4HA3(2), RARS(4), RARS2(5)	11973188	108	41	107	37	35	35	20	1	17	0	0.41	0.72
348	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(7), APOBEC1(2), APOBEC2(1), APOBEC3A(1), APOBEC3C(3), APOBEC3F(2), APOBEC3G(3), APOBEC4(4)	2471012	23	16	23	5	9	8	3	1	2	0	0.41	0.72
349	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(3), ACOX3(7), ELOVL2(3), ELOVL5(1), ELOVL6(1), FADS2(4), FASN(1), HADHA(3), HSD17B12(2), SCD(2)	4616912	29	23	29	10	13	7	4	1	4	0	0.41	0.72
350	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(10), AZIN1(2), BTG1(1), CBX3(3), CLOCK(8), CRY1(5), CRY2(1), DNAJA1(2), EIF4G2(7), ETV6(5), GFRA1(8), GSTM3(3), HERPUD1(1), HSPA8(4), IDI1(1), MYF6(2), NCKAP1(9), NCOA4(4), NR1D2(6), PER1(1), PER2(2), PPP1R3C(4), PPP2CB(2), PSMA4(2), SF3A3(1), SUMO3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(7), ZFR(6)	12361876	114	40	110	22	38	33	27	1	14	1	0.41	0.72
351	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(4), SNAP25(1), STX1A(2)	1094156	10	10	10	4	6	2	2	0	0	0	0.41	0.72
352	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), NFAT5(5), PDE6A(7), PDE6B(5), PDE6C(10), PDE6D(1), SLC6A13(6), TF(11)	12253428	111	44	111	27	44	34	21	0	11	1	0.41	0.72
353	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	16	ABCA1(22), APOC1(1), APOC2(1), APOE(1), CETP(7), CYP7A1(4), HMGCR(3), LCAT(1), LDLR(5), LIPC(4), LPL(6), LRP1(17), SCARB1(1), SOAT1(1)	8566096	74	36	74	23	31	23	13	1	6	0	0.41	0.72
354	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), HGSNAT(6), HPSE(2), HPSE2(12), IDS(2), IDUA(1), LCT(20), NAGLU(4), SPAM1(4)	6988988	72	32	70	19	28	20	15	1	8	0	0.42	0.72
355	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	19	AXIN1(2), BTRC(5), CREBBP(25), CSNK1A1(2), CSNK1D(4), CSNK2A1(4), CTBP1(1), FZD1(1), HDAC1(2), MAP3K7(4), NLK(1), PPARD(2), PPP2CA(1), TLE1(1), WIF1(2), WNT1(1)	7016728	58	34	58	22	22	11	15	1	9	0	0.42	0.73
356	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(6), AKT3(1), CDKN1A(1), GRB2(3), MAP2K1(4), MAP2K2(1), NGFR(3), NTRK1(6), PIK3CD(3), SHC1(3), SOS1(7)	4772900	40	26	39	13	11	14	11	0	4	0	0.42	0.73
357	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(4), ACTB(2), ARHGEF2(5), ARPC5(1), ARPC5L(2), CD14(1), CDC42(1), CDH1(5), CTTN(1), EZR(2), FYN(5), ITGB1(6), KRT18(2), LY96(2), NCK1(1), NCL(3), OCLN(1), PRKCA(4), RHOA(5), ROCK1(15), ROCK2(6), TLR4(10), TLR5(4), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3), WAS(1), WASL(7), YWHAQ(1)	16587304	149	52	148	52	54	53	26	1	15	0	0.43	0.73
358	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(4), ACTB(2), ARHGEF2(5), ARPC5(1), ARPC5L(2), CD14(1), CDC42(1), CDH1(5), CTTN(1), EZR(2), FYN(5), ITGB1(6), KRT18(2), LY96(2), NCK1(1), NCL(3), OCLN(1), PRKCA(4), RHOA(5), ROCK1(15), ROCK2(6), TLR4(10), TLR5(4), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3), WAS(1), WASL(7), YWHAQ(1)	16587304	149	52	148	52	54	53	26	1	15	0	0.43	0.73
359	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), DLAT(3), DLD(1), DLST(1), FH(1), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), PC(6), PDHA1(5), PDHA2(8), PDHB(2), PDHX(2), PDK1(2), PDK2(2), PDK3(1), PDK4(3), PDP2(1), SDHA(6), SDHB(2), SDHD(1), SUCLA2(5), SUCLG1(2)	9641104	75	37	74	28	32	20	11	0	12	0	0.43	0.73
360	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1)	7851096	66	36	66	12	25	24	12	1	4	0	0.43	0.73
361	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CCR5(1), CD3D(1), CD3G(2), ETV5(6), IFNG(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), JAK2(9), MAP2K6(3), MAPK14(3), MAPK8(7), STAT4(3), TYK2(1)	5851812	48	24	49	21	8	21	9	1	7	2	0.43	0.73
362	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	53	BMP2(1), BMP4(2), BMP5(5), BMP6(3), BMP7(6), BMP8A(1), BTRC(5), CSNK1A1(2), CSNK1A1L(5), CSNK1D(4), CSNK1G1(1), CSNK1G3(3), DHH(1), FBXW11(8), GLI1(4), GLI2(4), GLI3(13), HHIP(5), IHH(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKX(2), PTCH1(9), PTCH2(6), RAB23(2), SMO(1), STK36(5), SUFU(4), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2), ZIC2(1)	16733816	143	58	143	68	64	35	23	1	20	0	0.43	0.73
363	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), IL6(2), LDLR(5), LPL(6)	1784860	16	12	16	4	6	4	4	0	2	0	0.43	0.74
364	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(5), CSF1R(3), EGF(3), EGFR(11), GRB2(3), MET(5), PDGFRA(17), PRKCA(4), SH3GLB1(4), SH3GLB2(2), SH3KBP1(4), SRC(3)	6577212	64	28	64	29	20	24	15	0	4	1	0.44	0.75
365	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(3), IFNGR2(2), JAK1(4), JAK2(9), STAT1(6)	2773344	25	15	24	7	8	6	6	0	3	2	0.45	0.75
366	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(1), BAX(1), BCL2(1), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), NFKB1(6), NSMAF(3), RAF1(6), RELA(2), RIPK1(2), SMPD1(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	6318392	55	29	54	17	25	14	10	2	4	0	0.45	0.75
367	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	10	CPB2(2), F2(3), FGB(2), FGG(4), PLAT(5), PLAU(3), PLG(9), SERPINB2(5), SERPINE1(3)	3433168	36	20	36	12	11	15	6	0	4	0	0.45	0.76
368	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(5), CD28(2), CD3D(1), CSK(3), CTLA4(2), DAG1(5), DTYMK(1), EPHB2(8), GRAP2(5), GRB2(3), ITPKB(4), LAT(1), LCK(3), LCP2(3), MAPK1(2), NCK1(1), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PLCG1(4), PTPRC(17), RAF1(6), RASGRP1(5), RASGRP2(7), RASGRP3(7), RASGRP4(2), SOS1(7), SOS2(11), VAV1(13), ZAP70(4)	17837868	171	57	168	54	66	62	28	2	13	0	0.45	0.76
369	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(8), ARHGDIB(3), BIRC2(4), BIRC3(7), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP9(2), DFFA(3), DFFB(2), GZMB(2), LMNB1(4), LMNB2(1)	6110152	52	28	51	15	12	22	10	0	8	0	0.46	0.76
370	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(5), CHIT1(5), CMAS(8), CTBS(4), CYB5R1(3), CYB5R3(1), GFPT1(4), GFPT2(4), GNE(2), GNPDA2(1), HEXB(3), HK1(6), HK2(3), HK3(5), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), NAGK(2), NANS(1), NPL(3), PGM3(5), PHPT1(1), RENBP(1)	9678628	80	41	79	24	32	27	14	1	6	0	0.46	0.76
371	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), IDS(2), IDUA(1), LCT(20), NAGLU(4)	4901776	48	27	48	13	21	12	10	0	5	0	0.46	0.76
372	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(1), FOS(1), FYN(5), MAPK14(3), THBS1(10)	2470356	22	16	22	8	7	10	3	0	2	0	0.47	0.78
373	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	CD3D(1), CD3G(2), GZMB(2), HLA-A(3), ICAM1(2), ITGAL(8), ITGB2(5)	2770024	23	17	23	8	7	6	4	0	6	0	0.47	0.78
374	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(8), BCL2(1), CASP3(2), CASP9(2), DAXX(1), FAS(2), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK2(3), MAPKAPK3(1)	3763944	28	20	28	11	7	11	6	0	4	0	0.48	0.78
375	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(1), F11(4), F12(2), F13B(5), F2(3), F5(21), F7(3), F8(18), F9(6), FGB(2), FGG(4), LPA(10), PLAT(5), PLAU(3), PLG(9), SERPINB2(5), SERPINE1(3), VWF(15)	11177176	119	41	116	43	28	56	20	0	15	0	0.48	0.79
376	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	15	CSNK2A1(4), FOS(1), GRB2(3), MAP2K1(4), MAPK3(3), MAPK8(7), NGFR(3), PLCG1(4), RAF1(6), SHC1(3), SOS1(7)	4952828	45	26	43	9	14	15	12	1	3	0	0.48	0.79
377	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(7), FADS2(4), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4)	3482308	28	18	27	9	14	4	6	1	3	0	0.48	0.79
378	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT1(2), AGPAT3(3), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(14), ENPP6(2), PAFAH1B1(3), PAFAH1B3(2), PAFAH2(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLD1(11), PLD2(2), PPAP2B(1)	7597596	61	32	60	27	23	24	11	0	3	0	0.48	0.79
379	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), ATIC(4), DHFR(1), FTCD(2), GART(3), MTFMT(2), MTHFD1(6), MTHFD1L(8), MTHFR(7), MTHFS(1), MTR(7), SHMT1(2), SHMT2(2), TYMS(3)	6387856	54	30	53	15	22	18	7	1	6	0	0.49	0.79
380	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ACSS2(6), ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH7A1(3), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), G6PC2(1), GALM(2), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKL(1), PFKM(4), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(7), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	19321516	174	59	172	58	57	68	36	1	12	0	0.49	0.79
381	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(1), AOC2(4), AOC3(4), CES1(5), CES7(1), DDHD1(3), ESCO1(11), ESCO2(4), LIPA(1), MYST3(18), MYST4(10), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(2), SH3GLB1(4)	8536896	80	35	79	27	31	24	17	1	7	0	0.49	0.79
382	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(3), AASS(9), ACAT1(1), ACAT2(2), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(5), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), HSD3B7(2), NSD1(14), OGDH(4), OGDHL(11), PIPOX(4), PLOD1(4), PLOD2(5), PLOD3(4), RDH11(1), RDH12(3), RDH13(1), SETD1A(8), SETD7(3), SETDB1(8), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(3), TMLHE(3)	19406496	157	55	154	43	63	40	29	2	23	0	0.50	0.80
383	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT2(5), ALAS1(6), ALAS2(6), AOC2(4), AOC3(4), BHMT(5), CBS(3), CHDH(2), CHKA(4), CPT1B(5), CTH(2), DAO(6), DLD(1), DMGDH(7), GAMT(1), GARS(3), GATM(1), GCAT(1), GLDC(3), MAOA(3), MAOB(1), PEMT(1), PISD(2), PLCB2(3), PLCG1(4), PLCG2(13), SARDH(8), SARS(2), SHMT1(2), SHMT2(2), TARS(6)	14310036	117	49	115	43	52	39	12	0	14	0	0.50	0.80
384	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	24	ABAT(5), ABP1(1), ACADM(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYS(7), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), HIBCH(1), MLYCD(1), SMS(2), UPB1(5)	8361792	85	36	84	24	30	31	13	1	10	0	0.50	0.81
385	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(1), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), AOC2(4), AOC3(4), ASPA(5), CNDP1(3), DDC(1), HAL(4), HARS(2), HDC(8), HNMT(4), MAOA(3), MAOB(1), PRPS1(1), PRPS2(2)	8248076	80	40	80	27	31	30	16	0	3	0	0.51	0.81
386	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12A(1), IL12B(2), IL2(4)	1022608	10	7	10	6	0	10	0	0	0	0	0.51	0.81
387	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(5), EIF2B1(2), EIF2B2(1), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), ELAVL1(3), FLT1(12), FLT4(5), HIF1A(3), KDR(10), NOS3(2), PLCG1(4), PRKCA(4), PTK2(5), SHC1(3), VHL(1)	10076004	69	39	68	27	24	22	13	0	10	0	0.51	0.81
388	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(9), AMY2B(1), ENPP1(4), ENPP3(4), G6PC(4), GANAB(4), GBA3(3), GBE1(5), GCK(2), GPI(2), GUSB(2), GYS1(2), GYS2(11), HK1(6), HK2(3), HK3(5), MGAM(13), PGM1(4), PGM3(5), PYGB(4), PYGL(2), PYGM(4), SI(15), UCHL1(2), UCHL3(2), UGDH(4), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3), UXS1(7)	18819492	153	54	153	54	52	51	31	0	19	0	0.51	0.81
389	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	12	F10(1), F2(3), F3(2), F5(21), F7(3), FGB(2), FGG(4), PROC(1), PROS1(6), SERPINC1(3), TFPI(3)	4875624	49	22	49	16	9	27	9	0	4	0	0.51	0.81
390	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ACTG2(3), ADCY3(2), ADCY9(6), ARF4(3), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), ERO1L(2), GNAS(6), PDIA4(5), PLCG1(4), PLCG2(13), PRKCA(4), SEC61A1(5), SEC61A2(1), SEC61B(1), TRIM23(9)	12198812	98	47	91	32	47	24	19	1	7	0	0.51	0.81
391	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	CCNA1(6), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDC25A(2), CDK2(2), CDK4(3), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), CREB3(3), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F2(1), E2F3(2), E2F4(1), E2F5(2), GBA2(5), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), MNAT1(1), MYT1(13), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), POLA2(2), POLE(21), POLE2(1), RB1(7), RBL1(5), RPA1(2), RPA2(1), TFDP1(4), TFDP2(1), TNXB(17), WEE1(3)	23077576	166	59	163	42	50	59	34	2	20	1	0.52	0.82
392	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(3), ACTR2(2), ACTR3(3), AKT1(2), ANGPTL2(8), CDC42(1), CFL1(1), FLNA(3), FLNC(13), FSCN3(2), GDI1(1), GDI2(1), LIMK1(5), MYH2(12), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PFN2(1), RHO(3), ROCK1(15), ROCK2(6), RPS4X(2), VASP(3), WASF1(3), WASL(7)	16002580	135	53	135	37	45	45	23	1	21	0	0.52	0.82
393	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(15), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADIPOQ(4), ADIPOR1(1), ADIPOR2(3), AKT1(2), AKT2(6), AKT3(1), CAMKK1(1), CAMKK2(1), CD36(1), CHUK(6), CPT1A(6), CPT1B(5), CPT2(2), G6PC(4), G6PC2(1), IKBKB(4), IRS1(8), IRS4(15), JAK1(4), JAK2(9), JAK3(8), LEP(1), LEPR(9), MAPK8(7), MAPK9(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NPY(2), PCK1(3), PCK2(3), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKAG1(1), PRKAG2(3), PRKAG3(6), PRKCQ(5), PTPN11(5), RELA(2), RXRA(1), RXRB(3), RXRG(4), SLC2A1(1), SLC2A4(4), STAT3(2), TNFRSF1A(1), TRADD(1), TRAF2(1), TYK2(1)	27451808	237	68	235	80	74	86	44	5	26	2	0.53	0.82
394	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), C9orf95(1), CD38(2), ENPP1(4), ENPP3(4), NADK(2), NADSYN1(2), NMNAT1(2), NMNAT2(2), NMNAT3(2), NNMT(3), NNT(3), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), NUDT12(2), QPRT(1)	7314932	59	32	59	24	20	20	11	0	8	0	0.53	0.82
395	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	78	ABL1(4), BUB1(6), BUB1B(6), BUB3(2), CCNA1(6), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDAN1(3), CDC14A(4), CDC14B(4), CDC20(3), CDC25A(2), CDC25B(5), CDC25C(4), CDC6(1), CDC7(3), CDH1(5), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DTX4(3), E2F2(1), E2F3(2), E2F4(1), E2F5(2), EP300(15), ESPL1(8), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(2), HDAC6(6), MAD1L1(2), MAD2L1(1), MAD2L2(1), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), MPEG1(4), MPL(2), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), PLK1(8), PRKDC(18), PTPRA(2), PTTG1(1), RB1(7), RBL1(5), SKP2(1), TBC1D8(5), TFDP1(4), TGFB1(1), WEE1(3)	34750908	237	72	234	70	66	75	60	6	29	1	0.53	0.83
396	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(1), CASP3(2), CFL1(1), CFLAR(3), PDE6D(1)	891972	8	7	8	2	2	4	2	0	0	0	0.53	0.83
397	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST6GALNAC2(2), ST6GALNAC4(2), ST8SIA1(3)	1894452	12	11	12	4	2	3	5	0	2	0	0.54	0.83
398	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	5125316	40	25	39	10	14	14	8	0	4	0	0.54	0.83
399	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	5125316	40	25	39	10	14	14	8	0	4	0	0.54	0.83
400	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	5125316	40	25	39	10	14	14	8	0	4	0	0.54	0.83
401	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), CXCL12(1), CXCR4(4), FOS(1), GNAQ(4), MAPK14(3), MAPK8(7), PLCG1(4), PRKCA(4), PTK2B(1), SYT1(1)	4495712	31	22	32	12	9	11	5	1	5	0	0.54	0.83
402	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(11), AKT1(2), BAX(1), CDKN1A(1), CPB2(2), CSNK1A1(2), CSNK1D(4), FHL2(2), HIF1A(3), IGFBP3(4), MAPK8(7), MDM2(4), NFKBIB(1), NQO1(1)	4462340	45	25	45	5	11	14	15	2	3	0	0.54	0.83
403	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA4(2), NDUFB2(1), NDUFB6(1), NDUFS1(6), NDUFS2(3), NDUFV1(2)	2338256	18	14	18	6	7	6	3	0	2	0	0.54	0.83
404	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(8), ITGAL(8), ITGB1(6), ITGB2(5), PECAM1(2), SELE(4), SELL(3)	4417984	41	22	39	11	9	19	9	0	4	0	0.55	0.83
405	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(1), GRIN1(1), HIF1A(3), JAK2(9), NFKB1(6), RELA(2), SOD2(4)	4318920	31	20	31	9	10	9	5	0	5	2	0.55	0.83
406	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(8), ITGAL(8), ITGAM(8), ITGB1(6), ITGB2(5), PECAM1(2), SELE(4), SELL(3), SELP(6)	5770408	55	26	53	16	15	24	10	0	6	0	0.55	0.83
407	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(2)	387336	3	2	3	1	1	1	0	0	1	0	0.55	0.83
408	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(4), CYP1A2(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2J2(3), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), HSD3B7(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), RDH11(1), RDH12(3), RDH13(1)	8076436	66	31	65	28	26	19	16	0	4	1	0.55	0.83
409	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(4), AOC3(4), CES1(5), ESD(1)	1980104	15	14	15	9	6	7	2	0	0	0	0.55	0.83
410	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(2), AKT2(6), AKT3(1), DAG1(5), GNAQ(4), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(6), PIK3CB(2), PITX2(2), PLD1(11), PLD2(2), PLD3(5), VN1R1(4)	15142744	119	46	119	40	50	35	18	2	13	1	0.56	0.83
411	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(4), FOS(1), MAPK3(3), OPRK1(5), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	4266716	33	23	33	8	16	7	6	1	3	0	0.56	0.83
412	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	DLG4(3), GRIN1(1), GRIN2B(10), GRIN2C(4), GRIN2D(5), NOS1(11), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), SYT1(1)	7587044	64	31	64	28	30	17	8	0	9	0	0.56	0.83
413	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(18), ACAT1(1), ACAT2(2), ACYP1(2), ADH5(1), AKR1B1(3), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), DLAT(3), DLD(1), GRHPR(1), LDHA(2), LDHB(3), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME2(3), ME3(5), PC(6), PCK1(3), PDHA1(5), PDHA2(8), PDHB(2), PKM2(2)	12020216	109	41	107	36	38	38	20	1	12	0	0.56	0.83
414	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(2), HMGCL(1), OXCT1(3)	1135008	7	7	7	3	2	4	1	0	0	0	0.56	0.83
415	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKM(4), PFKP(2), PGAM1(3), PGK1(3), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	16298620	154	54	152	49	51	58	35	0	10	0	0.56	0.83
416	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKM(4), PFKP(2), PGAM1(3), PGK1(3), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	16298620	154	54	152	49	51	58	35	0	10	0	0.56	0.83
417	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	40	AKT1(2), AKT2(6), AKT3(1), EIF4B(2), FIGF(2), HIF1A(3), IGF1(2), MAPK1(2), MAPK3(3), PDPK1(1), PGF(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PRKAA1(3), PRKAA2(9), RICTOR(13), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), RPS6KB2(2), TSC1(4), TSC2(2), ULK1(1), ULK2(4), ULK3(3), VEGFA(2), VEGFB(2), VEGFC(6)	15534456	121	44	119	39	47	38	20	0	16	0	0.56	0.83
418	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(2), GHR(6), GRB2(3), INSR(6), IRS1(8), JAK2(9), MAP2K1(4), MAPK1(2), MAPK3(3), PLCG1(4), PRKCA(4), PTPN6(4), RAF1(6), RPS6KA1(1), SHC1(3), SLC2A4(4), SOS1(7), SRF(3), STAT5B(3)	9835524	82	37	80	29	29	29	15	0	7	2	0.56	0.83
419	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(5), CDK7(1), CDKN1A(1), CHEK1(1), NEK1(9), WEE1(3)	2529196	22	14	21	7	7	8	4	2	1	0	0.57	0.84
420	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACAT2(2), ACOT11(3), ACYP1(2), DHRS1(1), DHRS2(3), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(11), ESCO2(4), GCDH(5), HADHA(3), ITGB1BP3(1), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4), YOD1(1)	8546528	79	35	78	23	31	21	15	2	10	0	0.58	0.84
421	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADL(2), ACADM(6), ACADSB(5), ACADVL(1), ACAT1(1), ACAT2(2), ACOX1(3), ACOX3(7), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CPT1A(6), CPT1B(5), CPT2(2), CYP4A11(3), CYP4A22(2), ECHS1(2), EHHADH(2), GCDH(5), HADH(1), HADHA(3), HADHB(2), HSD17B10(2), HSD17B4(3), PECI(1)	16484772	143	48	142	45	39	48	35	4	17	0	0.58	0.84
422	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	91	B3GALT4(1), CDR1(2), DGKI(10), FAU(1), IL6ST(3), MRPL19(1), PIGK(4), RPL10(1), RPL11(1), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL24(1), RPL28(2), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL4(2), RPL5(1), RPL6(3), RPL7(1), RPL9(4), RPLP0(2), RPS11(1), RPS13(1), RPS16(2), RPS18(2), RPS2(1), RPS20(1), RPS23(4), RPS3(2), RPS4X(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), RPS6KB2(2), RPS9(2), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(2), UBA52(2), UBB(2)	14474408	103	47	101	30	35	29	24	1	14	0	0.58	0.85
423	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	24	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2(1), GRB2(3), GSK3A(2), IL4R(1), IRS1(8), JAK1(4), JAK3(8), MAP4K1(3), MAPK1(2), MAPK3(3), PDK1(2), PIK3CD(3), PPP1R13B(6), RAF1(6), SHC1(3), SOS1(7), SOS2(11), STAT6(2)	10694424	85	39	82	24	27	29	16	0	13	0	0.59	0.85
424	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(3), IL4(3), IL4R(1), IRS1(8), JAK1(4), JAK3(8), RPS6KB1(3), SHC1(3), STAT6(2)	4961496	37	24	35	12	11	14	5	0	7	0	0.59	0.85
425	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN2(1), UBE2A(2), UBE3A(11)	4398832	34	18	34	12	10	11	9	1	3	0	0.59	0.85
426	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(2), ACYP1(2), ECHS1(2), EHHADH(2), GCDH(5), HADHA(3), SDHB(2), SDS(2)	2645360	21	13	21	3	6	7	2	1	5	0	0.59	0.85
427	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(2), AKT2(6), AKT3(1), BCR(7), BTK(7), CD19(3), CDKN2A(1), DAPP1(2), FLOT1(3), GAB1(6), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), PDK1(2), PHF11(2), PITX2(2), PLCG2(13), PPP1R13B(6), PREX1(16), PTPRC(17), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SAG(1), SYK(3), TEC(3), VAV1(13)	17807280	188	55	185	55	72	58	31	2	24	1	0.59	0.85
428	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(18), ACACB(15), ACAT1(1), ACAT2(2), ACOT12(9), ACSS1(3), ACSS2(6), ACYP1(2), AKR1B1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), DLAT(3), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME2(3), ME3(5), PC(6), PCK1(3), PCK2(3), PDHA1(5), PDHA2(8), PDHB(2), PKM2(2)	15314464	142	46	140	44	48	52	22	2	18	0	0.60	0.86
429	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATR(17), BRCA1(6), CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(4), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(15), MDM2(4), MYT1(13), PRKDC(18), RPS6KA1(1), WEE1(3), YWHAH(1), YWHAQ(1)	12184192	95	41	94	24	30	33	21	2	9	0	0.60	0.86
430	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), CDC42(1), WASF1(3), WASL(7)	2755360	29	17	29	6	11	9	6	0	3	0	0.60	0.86
431	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(4), IL8(1), NFKB1(6), NOX1(1), RELA(2), XDH(7)	3343964	23	16	23	8	8	6	6	0	3	0	0.60	0.86
432	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	13	DYRK1A(5), DYRK1B(4), GLI2(4), GLI3(13), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), SMO(1), SUFU(4)	5122500	44	27	44	24	19	13	6	0	6	0	0.61	0.86
433	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNAR2(2), IFNB1(1), JAK1(4), STAT1(6), STAT2(7), TYK2(1)	3630512	25	18	24	6	11	6	5	0	3	0	0.61	0.86
434	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), GOT1(6), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME2(3), ME3(5), PGK1(3), PKM2(2), RPE(2), RPIA(3), TKT(3), TPI1(1)	5538892	45	28	44	17	15	19	7	0	4	0	0.61	0.86
435	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(6), AKT3(1), GRB2(3), IARS(6), IL13RA1(2), IL4(3), IL4R(1), INPP5D(4), JAK1(4), JAK2(9), JAK3(8), PI3(1), PPP1R13B(6), RPS6KB1(3), SERPINA4(5), SHC1(3), SOS1(7), SOS2(11), SRC(3), STAT6(2), TYK2(1)	11778356	91	40	88	30	26	33	16	1	13	2	0.61	0.86
436	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(3), COQ6(2), COQ7(1), NDUFA12(2), NDUFA13(1)	1402476	9	8	9	2	1	4	2	0	2	0	0.61	0.86
437	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2L1(1), CDC42(1), CDK2(2), CDKN1B(3), CDKN2A(1), CREB1(1), CREB3(3), CREB5(4), EBP(2), F2RL2(3), GAB1(6), GRB2(3), GSK3A(2), IGF1(2), IGFBP1(2), INPPL1(4), IRS1(8), IRS4(15), MET(5), NOLC1(8), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PARD3(7), PARD6A(2), PDK1(2), PIK3CD(3), PPP1R13B(6), PREX1(16), PTK2(5), PTPN1(5), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SHC1(3), SLC2A4(4), SOS1(7), SOS2(11), TSC1(4), TSC2(2), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	23432616	210	58	207	77	72	71	35	3	29	0	0.61	0.86
438	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), FOS(1), GRB2(3), IL2(4), IL2RA(2), IL2RB(2), JAK1(4), JAK3(8), LCK(3), MAP2K1(4), MAPK3(3), MAPK8(7), RAF1(6), SHC1(3), SOS1(7), STAT5B(3), SYK(3)	7957296	67	33	64	19	19	27	12	1	8	0	0.61	0.86
439	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(6), ACADVL(1), ACSL1(3), ACSL3(6), ACSL4(4), CPT1A(6), CPT2(2), EHHADH(2), HADHA(3), SCP2(3), SLC25A20(2)	5661168	40	22	39	14	11	14	8	0	7	0	0.61	0.86
440	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(5), ARG1(1), ARG2(5), ASL(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), GAMT(1), GATM(1), GLUD1(2), NAGS(1), OAT(1), ODC1(5), OTC(5), SMS(2)	5843016	58	26	58	18	19	20	9	0	10	0	0.62	0.86
441	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(1), BCR(7), BLNK(1), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8IP3(2), RPS6KA1(1), RPS6KA3(5), SHC1(3), SOS1(7), SYK(3), VAV1(13), VAV2(4), VAV3(12)	9684908	84	39	82	18	30	31	15	0	8	0	0.62	0.86
442	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(8), ITGAM(8), ITGB2(5), PECAM1(2), SELE(4), SELL(3)	3904096	35	21	35	10	10	16	5	0	4	0	0.62	0.86
443	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3D(1), CD3G(2), CD4(2)	949080	8	7	9	5	3	4	0	0	1	0	0.62	0.87
444	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	62	APAF1(8), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BCL2L11(3), BID(1), BIRC2(4), BIRC3(7), BNIP3L(3), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP9(2), CHUK(6), DFFA(3), DFFB(2), FAS(2), FASLG(1), GZMB(2), HELLS(5), IKBKB(4), IRF1(1), IRF2(3), IRF3(2), IRF4(3), IRF5(3), IRF6(2), MAP3K1(8), MDM2(4), NFKB1(6), NFKBIB(1), NFKBIE(2), RELA(2), RIPK1(2), TNFRSF10B(6), TNFRSF1A(1), TNFRSF21(5), TNFSF10(1), TRADD(1), TRAF1(2), TRAF2(1), TRAF3(6)	17957824	136	52	135	46	47	44	25	2	18	0	0.63	0.87
445	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(4), DHFR(1), GART(3), MTHFD1(6), MTHFD1L(8), MTHFR(7), MTHFS(1), MTR(7), SHMT1(2), SHMT2(2), TYMS(3)	6058280	50	28	49	14	21	17	7	1	4	0	0.63	0.87
446	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	2697372	33	19	33	5	13	12	7	0	1	0	0.63	0.87
447	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	2697372	33	19	33	5	13	12	7	0	1	0	0.63	0.87
448	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(6), DUSP1(2), IKBKAP(2), IKBKB(4), MAP3K1(8), MAP3K14(3), NFKB1(6), RELA(2), TNFAIP3(3), TRAF3(6), TRAF6(4)	6191184	46	25	46	16	20	13	6	1	6	0	0.63	0.87
449	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT2(5), ALAS1(6), ALAS2(6), AOC2(4), AOC3(4), BHMT(5), CBS(3), CHDH(2), CHKA(4), CTH(2), DAO(6), DLD(1), DMGDH(7), GAMT(1), GARS(3), GATM(1), GCAT(1), GLDC(3), GNMT(1), HSD3B7(2), MAOA(3), MAOB(1), PEMT(1), PHGDH(2), PIPOX(4), PISD(2), PSAT1(4), RDH11(1), RDH12(3), RDH13(1), SARDH(8), SARS(2), SARS2(2), SDS(2), SHMT1(2), SHMT2(2), TARS(6), TARS2(5)	14581668	119	47	119	45	48	44	14	0	13	0	0.64	0.87
450	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(1), ACAT2(2), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), SDS(2)	2829676	17	13	17	7	3	8	2	0	4	0	0.64	0.87
451	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(6), HK2(3), HK3(5), IMPA1(2), IMPA2(2), PGM1(4), PGM3(5), TGDS(1)	3892472	30	22	30	12	10	15	4	0	1	0	0.64	0.87
452	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(7), DLL1(4), FURIN(3), PSEN1(3)	2877556	17	13	17	3	7	2	2	0	6	0	0.64	0.87
453	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(1), SP1(2), SP3(3), WT1(6)	2055316	14	12	14	4	8	3	3	0	0	0	0.64	0.87
454	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	52	AXIN1(2), CCND2(1), CCND3(1), DVL2(9), DVL3(4), FBXW2(3), FZD1(1), FZD10(6), FZD2(2), FZD6(6), FZD7(3), FZD8(1), LDLR(5), MAPK9(5), PAFAH1B1(3), PLAU(3), PPP2R5C(3), PPP2R5E(2), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), RHOA(5), SFRP4(4), TCF7(6), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2)	15717508	137	60	134	50	62	36	21	1	17	0	0.64	0.87
455	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(4), PGLYRP2(2)	615540	6	5	6	2	2	2	1	0	1	0	0.64	0.87
456	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(6), ALAS2(6), CPOX(1), FECH(3), HMBS(2), PPOX(3), UROD(1), UROS(1)	2600832	24	15	24	5	13	8	2	0	1	0	0.65	0.87
457	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PNPO(1), PSAT1(4)	1634620	13	9	13	5	4	5	2	0	2	0	0.65	0.87
458	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(10), CLOCK(8), CRY1(5), CRY2(1), CSNK1D(4), NPAS2(5), NR1D1(4), PER1(1), PER2(2), PER3(9)	5763680	49	27	47	9	20	13	8	2	5	1	0.65	0.87
459	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), FDXR(1), SHMT1(2)	5431384	41	25	40	11	14	15	8	0	4	0	0.65	0.87
460	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	AKT1(2), AKT2(6), AKT3(1), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GRB2(3), GSK3A(2), IARS(6), IGFBP1(2), INPP5D(4), PDK1(2), PPP1R13B(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SHC1(3), SOS1(7), SOS2(11), TEC(3), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	10842672	95	38	93	27	28	33	22	0	12	0	0.65	0.87
461	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(2), IFNAR1(3), IFNAR2(2), IFNB1(1), MAPK8(7), NFKB1(6), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(4)	3708116	32	17	32	10	12	9	5	1	5	0	0.65	0.87
462	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(18), ATP4B(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), ATP7B(4), COX10(2), COX4I1(2), COX6A2(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFA4(2), NDUFB2(1), NDUFB6(1), NDUFS1(6), NDUFS2(3), NDUFV1(2), PPA2(3), SDHA(6), SDHB(2), SHMT1(2), UQCRB(2), UQCRC1(2), UQCRFS1(1), UQCRH(1)	11886872	105	41	104	30	40	39	17	0	9	0	0.65	0.87
463	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	59	APAF1(8), ATR(17), BAI1(2), BAX(1), BID(1), CASP3(2), CASP9(2), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNG1(3), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGF1(2), IGFBP3(4), MDM2(4), MDM4(3), PPM1D(4), RCHY1(2), RFWD2(5), RPRM(1), RRM2(2), SERPINB5(2), SERPINE1(3), SESN1(2), SESN2(4), SIAH1(1), STEAP3(1), THBS1(10), TNFRSF10B(6), TP53I3(2), TSC2(2), ZMAT3(5)	18345844	135	55	135	39	42	53	28	1	11	0	0.65	0.87
464	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	AKT1(2), ANXA1(1), GNAS(6), GNB1(1), GNGT1(1), NFKB1(6), NOS3(2), NPPA(1), NR3C1(4), RELA(2), SYT1(1)	4728068	27	21	27	16	13	6	4	0	4	0	0.66	0.87
465	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(2), GRHPR(1), HAO1(5), HAO2(4), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(8)	4322352	33	21	32	13	12	11	5	2	3	0	0.66	0.87
466	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA14(2), CA2(1), CA3(2), CA4(1), CA5A(2), CA6(2), CA8(3), CA9(2), CPS1(14), CTH(2), GLS2(2), GLUD1(2), GLUL(4), HAL(4)	6325556	45	23	45	23	17	15	5	0	8	0	0.66	0.87
467	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(1), B3GALT2(3), B3GALT5(4), B3GNT5(1), FUT1(4), FUT2(1), FUT3(4), ST3GAL3(4), ST3GAL4(2)	2414396	26	16	26	5	13	7	4	0	2	0	0.66	0.87
468	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2), IL8(1)	570136	3	3	3	3	0	2	0	0	1	0	0.66	0.87
469	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), SDS(2)	4118656	42	23	42	8	16	14	7	0	5	0	0.66	0.87
470	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR2(2), PDE1A(4), PDE1B(3), PLCB1(8), PLCB2(3), PRL(3), TRH(2)	3389904	25	18	25	11	10	8	4	1	2	0	0.66	0.87
471	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	11	AHCY(3), CBS(3), CTH(2), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), PAPSS1(2), PAPSS2(4), SCLY(1), SEPHS1(3)	3814092	33	19	32	10	13	12	5	0	3	0	0.67	0.87
472	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(2), CREB1(1), GRB2(3), MAPK1(2), MAPK3(3), MAPK7(3), MEF2A(4), MEF2C(9), MEF2D(1), NTRK1(6), PLCG1(4), RPS6KA1(1), SHC1(3)	5297900	42	25	41	15	15	9	13	0	5	0	0.67	0.87
473	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	80	ATF2(1), CHUK(6), CREB1(1), DAXX(1), FOS(1), GRB2(3), IKBKB(4), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K5(4), MAP2K6(3), MAP3K1(8), MAP3K10(3), MAP3K11(4), MAP3K12(6), MAP3K13(9), MAP3K14(3), MAP3K2(3), MAP3K3(3), MAP3K5(6), MAP3K6(6), MAP3K7(4), MAP3K8(2), MAP3K9(4), MAP4K1(3), MAP4K2(1), MAP4K3(4), MAP4K4(8), MAP4K5(2), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK4(1), MAPK6(3), MAPK7(3), MAPK8(7), MAPK9(5), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(4), MEF2C(9), MEF2D(1), MKNK1(1), MKNK2(3), NFKB1(6), PAK1(5), PAK2(3), RAF1(6), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA5(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SP1(2), STAT1(6), TGFB1(1), TGFB2(9), TGFBR1(9), TRADD(1), TRAF2(1)	30655068	251	67	247	68	86	73	55	4	33	0	0.67	0.87
474	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(6), HK2(3), HK3(5), IMPA1(2), PGM1(4), PGM3(5), TGDS(1)	3425600	28	20	28	12	9	15	4	0	0	0	0.67	0.87
475	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), GPI(2), HK1(6), PFKL(1), PGAM1(3), PGK1(3), TPI1(1)	2944848	21	20	20	14	9	7	5	0	0	0	0.67	0.87
476	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	33	AKT1(2), ATF2(1), CDC42(1), DLD(1), DUSP10(5), DUSP4(1), GAB1(6), GCK(2), IL1R1(4), MAP2K5(4), MAP3K1(8), MAP3K10(3), MAP3K11(4), MAP3K12(6), MAP3K13(9), MAP3K2(3), MAP3K3(3), MAP3K5(6), MAP3K7(4), MAP3K9(4), MAPK7(3), MAPK8(7), MAPK9(5), MYEF2(7), NFATC3(5), NR2C2(4), SHC1(3), TRAF6(4), ZAK(6)	14005808	121	46	120	28	43	34	23	1	20	0	0.67	0.87
477	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(4), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(3), HSD3B2(1)	2321788	17	13	17	8	7	7	2	0	1	0	0.67	0.87
478	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(8), BIRC2(4), BIRC3(7), CASP10(2), CASP3(2), CASP7(1), CASP9(2), DFFA(3), DFFB(2), GZMB(2), SCAP(2), SREBF1(1), SREBF2(2)	5722936	38	23	38	16	8	16	7	0	7	0	0.68	0.87
479	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	21	AKT1(2), AXIN1(2), CD14(1), FZD1(1), GJA1(7), GNAI1(4), IRAK1(1), LBP(1), LEF1(4), LY96(2), MYD88(2), NFKB1(6), PDPK1(1), PPP2CA(1), RELA(2), TIRAP(1), TLR4(10), TOLLIP(1), WNT1(1)	6084236	50	30	50	22	24	10	11	0	5	0	0.68	0.87
480	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(2), HMOX1(2), IL10(2), IL10RA(2), IL10RB(5), IL1A(1), IL6(2), JAK1(4), STAT1(6), STAT3(2)	4071596	30	19	27	18	12	8	7	0	3	0	0.68	0.87
481	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(6), IFNA1(1), IFNB1(1), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(1), IL1RN(3), IL6(2), IRAK1(1), IRAK2(8), IRAK3(3), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K7(4), MAPK14(3), MAPK8(7), MYD88(2), NFKB1(6), RELA(2), TGFB1(1), TGFB2(9), TOLLIP(1), TRAF6(4)	9990076	95	34	94	24	36	29	17	3	10	0	0.68	0.87
482	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	55	ALG2(3), BAK1(1), BAX(1), BFAR(1), BTK(7), CAD(11), CASP10(2), CASP3(2), CASP8AP2(18), CD7(1), CSNK1A1(2), DAXX(1), DEDD(1), DFFA(3), DIABLO(1), EGFR(11), EPHB2(8), FAF1(4), FAIM2(3), IL1A(1), IL8(1), MAP3K1(8), MAP3K5(6), MAPK1(2), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MET(5), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PFN2(1), PTPN13(17), RALBP1(6), RIPK1(2), ROCK1(15), SMPD1(6), TPX2(8), TRAF2(1), TUFM(1)	23567284	195	57	191	56	65	65	42	3	19	1	0.68	0.87
483	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(4), PRKCA(4), PTK2B(1)	2269828	12	11	12	5	6	3	2	0	1	0	0.68	0.87
484	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(2), AFMID(1), GRHPR(1), HAO1(5), HAO2(4), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(8)	4532648	34	22	33	13	13	11	5	2	3	0	0.69	0.88
485	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(3), GLB1(3), HEXB(3), LCT(20), MAN2C1(6), MANBA(7), NEU1(1), NEU2(1), NEU3(1)	5527960	50	28	50	15	20	12	14	0	4	0	0.69	0.88
486	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	5	GBA3(3), SHMT1(2), SHMT2(2)	1587648	7	7	7	7	2	2	0	0	3	0	0.69	0.88
487	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(2), GALNT10(5), GALNT2(4), GALNT3(4), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2)	4434692	34	19	34	14	13	9	6	0	6	0	0.69	0.88
488	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(3), COPS5(1), CREB1(1), EDN1(1), EP300(15), HIF1A(3), LDHA(2), NOS3(2), P4HB(2), VHL(1)	5609492	36	24	36	11	12	7	12	1	4	0	0.69	0.88
489	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CYP2C19(4), CYP2C9(7), DHRS1(1), DHRS2(3), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(11), ESCO2(4), HADHA(3), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4), YOD1(1)	10243836	105	36	104	28	40	31	22	1	11	0	0.70	0.88
490	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(3), CDK2(2), DIAPH2(12), GMNN(1), MCM10(8), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), RFC1(14), RFC4(3), RFC5(3), RPA1(2), RPA2(1), RPA4(3), UBA52(2), UBB(2)	17190508	121	47	118	29	29	55	20	1	16	0	0.70	0.88
491	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), CSF1(2), FCGR3A(1), IL1B(1), IL6R(3), SELL(3), SPN(2), TGFB1(1), TGFB2(9), TNFRSF1A(1), TNFRSF8(2), TNFSF8(1)	4625192	31	18	31	14	8	11	5	0	7	0	0.70	0.88
492	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	74	AIFM1(2), AKT1(2), AKT2(6), AKT3(1), APAF1(8), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(4), BIRC3(7), CAPN1(2), CAPN2(6), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP9(2), CFLAR(3), CHUK(6), CSF2RB(7), DFFA(3), DFFB(2), FAS(2), FASLG(1), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(1), IL3(3), IRAK1(1), IRAK2(8), IRAK3(3), IRAK4(4), MAP3K14(3), MYD88(2), NFKB1(6), NFKB2(4), NTRK1(6), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(1)	23859160	198	59	196	62	75	62	37	0	24	0	0.70	0.88
493	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	IMPA1(2), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPP5B(1), INPPL1(4), IPMK(2), ITGB1BP3(1), ITPK1(2), ITPKB(4), MINPP1(1), MIOX(1), OCRL(9), PI4KA(15), PI4KB(2), PIK3C3(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PTPMT1(2), SYNJ1(11), SYNJ2(6)	24177448	187	61	183	53	75	51	36	2	22	1	0.70	0.88
494	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	25	ARHGDIB(3), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CFLAR(3), DAXX(1), DFFA(3), DFFB(2), FAF1(4), LMNB1(4), LMNB2(1), MAP3K1(8), MAP3K7(4), MAPK8(7), PAK1(5), PAK2(3), PRKDC(18), PTPN13(17), RB1(7), RIPK2(3), SPTAN1(13)	13834656	113	41	111	36	24	42	24	2	18	3	0.70	0.88
495	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(3), ABAT(5), ACAT1(1), ACAT2(2), ACSM1(5), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH7A1(3), ALDH9A1(1), BDH1(1), DDHD1(3), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADH(1), HADHA(3), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B10(2), HSD17B4(3), HSD3B7(2), ILVBL(2), L2HGDH(3), OXCT1(3), OXCT2(1), PDHA1(5), PDHA2(8), PDHB(2), PLA1A(3), PPME1(2), PRDX6(2), RDH11(1), RDH12(3), RDH13(1)	13826240	121	45	120	42	49	41	18	0	13	0	0.70	0.88
496	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(6), B4GALT2(3), FBP2(3), G6PC(4), GALE(1), GALK2(3), GALT(2), GANAB(4), GCK(2), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(5), LALBA(1), LCT(20), MGAM(13), PFKM(4), PFKP(2), PGM1(4), PGM3(5)	11029324	101	45	101	34	45	35	18	0	3	0	0.72	0.89
497	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(2), ALOX15B(5), ALOX5(4), ALOX5AP(1), DPEP1(1), PLA2G6(4), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	4740216	36	25	36	10	15	13	6	1	1	0	0.72	0.89
498	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), DAG1(5), GNAQ(4), ITPKB(4)	2002588	16	11	16	6	5	4	4	0	3	0	0.72	0.89
499	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(6), EGR2(8), EGR3(2), GNAQ(4), MAP3K1(8), NFATC1(2), NFATC2(5), NFKB1(6), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RELA(2), SYT1(1), VIPR2(3)	9165212	76	36	75	24	37	15	12	0	12	0	0.72	0.89
500	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	7	ACLY(4), MDH1(1), PC(6), PDHA1(5), SLC25A11(1)	2723708	17	16	17	7	8	5	2	0	2	0	0.73	0.90
501	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(2), AGPAT1(2), AGPAT3(3), AGPS(3), CDS1(2), CDS2(4), CHAT(6), CHKA(4), CLC(3), CPT1B(5), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), ETNK1(2), GNPAT(2), GPD1(1), GPD2(4), LCAT(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(5), PCYT1B(5), PEMT(1), PISD(2), PLA2G1B(1), PLA2G4A(8), PLA2G6(4), PLCB2(3), PLCG1(4), PLCG2(13), PPAP2B(1)	16681472	136	50	133	53	53	40	28	0	15	0	0.73	0.90
502	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(2), CDC25B(5), CDC25C(4), CDK7(1), MNAT1(1), XPO1(2)	2934044	19	14	19	9	6	8	3	1	1	0	0.73	0.90
503	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(2), CASP2(4), CHUK(6), CRADD(2), IKBKB(4), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP4K2(1), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), RIPK1(2), TANK(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	7970204	68	31	67	24	26	20	16	3	3	0	0.73	0.90
504	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(6), ALAS2(6), CPO(3), FECH(3), GATA1(5), HBB(3), HMBS(2), UROD(1), UROS(1)	2771624	31	17	30	6	16	12	2	0	1	0	0.73	0.90
505	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(3), IL4R(1), JAK1(4), JAK2(9), TYK2(1)	3524168	21	16	20	9	8	4	5	0	2	2	0.74	0.90
506	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(3), IL4R(1), JAK1(4), JAK2(9), TYK2(1)	3524168	21	16	20	9	8	4	5	0	2	2	0.74	0.90
507	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ENPP1(4), ENPP3(4), FLAD1(1), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), PHPT1(1), TYR(3)	5070056	35	22	34	19	14	9	8	0	3	1	0.74	0.90
508	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(3), CD33(2), CD5(4), CD7(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL12A(1), IL12B(2), IL13(1), IL3(3), IL4(3), ITGAX(6), TLR2(6), TLR4(10), TLR7(7), TLR9(7)	6257856	69	28	68	22	25	22	19	0	3	0	0.74	0.90
509	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(10), CLOCK(8), CRY1(5), CRY2(1), PER1(1)	2894204	25	14	24	5	8	7	5	0	4	1	0.74	0.90
510	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	22	ASAH1(3), CASP3(2), CERK(1), CREB1(1), CREB3(3), CREB5(4), DAG1(5), EPHB2(8), FOS(1), GNAQ(4), ITPKB(4), MAPK1(2), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5)	6942480	54	28	53	19	17	14	12	2	9	0	0.75	0.90
511	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(4), ACTA2(3), ACTN2(8), ACTN3(3), ACTN4(3), DES(1), FAM48A(6), MYBPC1(7), MYBPC2(4), MYBPC3(3), MYH3(14), MYH6(12), MYH7(11), MYH8(20), MYL1(1), MYL2(1), MYL4(1), MYL9(2), MYOM1(12), NEB(54), TMOD1(3), TNNC2(1), TNNI1(2), TNNI3(1), TNNT2(3), TPM1(2), TPM2(6), TPM3(3), TPM4(4), VIM(3)	19817992	198	57	190	69	82	69	25	3	18	1	0.75	0.90
512	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(3), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(2), MAN1A1(5), MAN1B1(2), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), RPN2(1), ST6GAL1(1)	6566708	48	31	48	17	20	14	10	0	4	0	0.75	0.90
513	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(3), CAMK1G(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), ESRRA(3), HDAC5(2), MEF2A(4), MEF2C(9), MEF2D(1), PPARA(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), SLC2A4(4), SYT1(1), YWHAH(1)	7001120	57	27	56	28	23	13	12	1	8	0	0.75	0.90
514	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(4), FUT2(1), FUT3(4), FUT6(1), ST3GAL3(4)	1627768	16	12	16	5	10	4	2	0	0	0	0.75	0.90
515	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(3), CD3D(1), CD3G(2), CD4(2), IFNG(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), JAK2(9), STAT4(3), TYK2(1)	4905964	34	18	35	19	5	17	6	0	4	2	0.76	0.91
516	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(6), CARM1(2), CREBBP(25), EP300(15), ERCC3(7), GRIP1(8), GTF2A1(2), GTF2E1(5), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(2), HDAC6(6), MEF2C(9), NCOR2(2), NR0B1(3), NRIP1(6), PELP1(2), POLR2A(6), TBP(1)	15606776	123	48	122	32	48	32	27	3	13	0	0.76	0.91
517	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), DHRS1(1), DHRS2(3), DHRS3(2), PON1(6), PON2(2), PON3(2)	5862196	42	24	41	17	16	12	8	0	4	2	0.76	0.91
518	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(7), CREBBP(25), CTBP1(1), CTBP2(2), DLL1(4), DLL3(3), DLL4(2), DTX1(4), DTX2(4), DTX3(1), DTX3L(3), DTX4(3), DVL2(9), DVL3(4), EP300(15), HDAC1(2), HDAC2(2), HES1(1), JAG1(8), MAML1(3), MAML2(3), MAML3(1), NCOR2(2), NCSTN(5), NOTCH2(13), NOTCH3(15), NOTCH4(7), NUMB(2), NUMBL(3), PSEN1(3), PSEN2(2), PTCRA(2), RBPJ(5), RBPJL(3), SNW1(5)	22901968	174	60	171	66	62	53	31	1	27	0	0.76	0.91
519	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(3), SDS(2)	1647524	9	7	9	3	3	2	0	0	4	0	0.76	0.91
520	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	124	ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), AKT1(2), AKT2(6), AKT3(1), AMOTL1(13), ASH1L(24), CASK(4), CDC42(1), CDK4(3), CGN(7), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CSDA(2), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTTN(1), EPB41(3), EPB41L1(9), EPB41L2(6), EPB41L3(18), EXOC4(7), F11R(1), GNAI1(4), IGSF5(8), INADL(5), JAM3(3), LLGL1(1), LLGL2(2), MAGI1(13), MAGI2(11), MAGI3(6), MLLT4(6), MPDZ(11), MPP5(3), MRAS(1), MYH1(15), MYH10(10), MYH11(28), MYH13(15), MYH14(12), MYH15(12), MYH2(12), MYH3(14), MYH4(12), MYH6(12), MYH7(11), MYH7B(6), MYH8(20), MYH9(12), MYL2(1), MYL7(1), MYL9(2), OCLN(1), PARD3(7), PARD6A(2), PARD6G(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2C(4), PPP2R3A(5), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), RAB3B(1), RHOA(5), RRAS2(2), SPTAN1(13), SRC(3), SYMPK(5), TJAP1(1), TJP1(7), TJP2(5), TJP3(1), YES1(1), ZAK(6)	63940364	585	106	575	193	249	178	91	3	61	3	0.77	0.92
521	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(1), ACY1(2), ADC(1), AGMAT(4), ALDH18A1(5), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(5), ASL(2), ASS1(2), CPS1(14), GATM(1), MAOA(3), MAOB(1), NAGS(1), ODC1(5), OTC(5), SAT2(2), SMS(2)	9900000	92	37	91	30	31	36	15	0	10	0	0.78	0.92
522	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(7), ADSS(2), DHFR(1), HPRT1(2), IMPDH1(2), POLB(3), POLD1(5), POLG(5), PRPS2(2), RRM1(2)	4338448	31	23	31	12	15	12	2	0	2	0	0.78	0.92
523	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), IDI1(1), SQLE(2)	1124384	6	5	6	3	1	2	2	0	1	0	0.79	0.93
524	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CASP9(2), CHUK(6), GH1(2), GHR(6), NFKB1(6), PDPK1(1), PPP2CA(1), RELA(2), YWHAH(1)	3524040	30	16	30	10	13	7	8	0	2	0	0.79	0.93
525	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(5), CERK(1), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GLA(4), GLB1(3), LCT(20), NEU1(1), NEU2(1), NEU3(1), PPAP2B(1), SGMS1(3), SGMS2(6), SGPP1(2), SGPP2(4), SMPD1(6), SMPD3(3), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC1(4), SPTLC2(2), UGCG(2), UGT8(8)	11820736	96	42	94	34	35	26	25	2	7	1	0.79	0.93
526	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(1), CAD(11), CDA(1), CTPS(4), CTPS2(4), DCK(2), DCTD(3), DHODH(4), DPYS(7), DTYMK(1), ENTPD1(2), ITPA(2), NT5E(3), NT5M(1), POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12), POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1), RRM1(2), RRM2(2), TK1(1), TK2(1), TXNRD1(3), TYMS(3), UCK2(1), UMPS(1), UNG(1), UPB1(5)	18763032	142	53	139	38	44	53	30	1	14	0	0.79	0.93
527	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(2), ACADL(2), ACADM(6), ACOX1(3), ACOX2(2), ACOX3(7), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADIPOQ(4), APOA2(1), APOA5(1), AQP7(1), CD36(1), CPT1A(6), CPT1B(5), CPT2(2), CYP27A1(3), CYP4A11(3), CYP4A22(2), CYP7A1(4), CYP8B1(3), EHHADH(2), FABP1(1), FABP2(2), FABP3(1), FABP4(1), FABP5(1), FABP6(1), FABP7(1), FADS2(4), GK(3), GK2(6), HMGCS2(1), LPL(6), MMP1(2), NR1H3(4), OLR1(2), PCK1(3), PCK2(3), PDPK1(1), PLTP(7), PPARA(1), PPARD(2), PPARG(1), RXRA(1), RXRB(3), RXRG(4), SCD(2), SCP2(3), SLC27A1(2), SLC27A2(3), SLC27A4(1), SLC27A5(4), SLC27A6(9), SORBS1(11), UCP1(1)	21344000	181	58	178	58	55	69	33	6	18	0	0.79	0.93
528	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(11), IGF1R(8), POLR2A(6), PPP2CA(1), PRKCA(4), RB1(7), TEP1(7), TERF1(1), TERT(2), TNKS(4), XRCC5(6)	9238124	60	38	60	20	27	16	11	1	4	1	0.80	0.93
529	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(11), ABCC2(14), ABCG2(9), CES1(5), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6)	7248572	63	25	63	20	23	18	14	1	7	0	0.80	0.93
530	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(5), HSD17B2(2), HSD17B3(2), HSD17B4(3), HSD3B1(3), HSD3B2(1)	2715720	18	12	18	4	5	7	4	0	2	0	0.80	0.93
531	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(4), UBE2A(2), UBE2B(2), UBE2C(2), UBE2D1(1), UBE2D3(1), UBE2E1(3), UBE2G1(2), UBE2I(2), UBE2J2(1), UBE2L3(2), UBE3A(11)	3526084	33	15	33	10	9	11	8	0	5	0	0.80	0.93
532	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), AGMAT(4), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(5), ASL(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), DAO(6), GAMT(1), GATM(1), GLUD1(2), GOT1(6), GOT2(1), MAOA(3), MAOB(1), NOS1(11), NOS3(2), OAT(1), ODC1(5), OTC(5), P4HA1(1), P4HA2(2), P4HA3(2), P4HB(2), RARS(4), SMS(2)	14740640	141	46	139	48	54	47	21	1	18	0	0.80	0.93
533	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(2), RAB9A(1)	1457536	13	9	13	2	4	6	2	0	1	0	0.80	0.93
534	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(2)	1486144	8	6	8	5	1	3	2	0	2	0	0.81	0.93
535	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAPK3(3), MAPK8(7), PLCG1(4), PTPN6(4), RAF1(6), SHC1(3), SOS1(7), STAT5B(3)	7317592	58	27	56	13	20	18	12	1	5	2	0.81	0.93
536	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12)	5719952	48	24	45	14	17	19	6	0	6	0	0.81	0.93
537	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(3), DERA(2), FBP2(3), G6PD(3), GPI(2), H6PD(4), PFKL(1), PFKM(4), PFKP(2), PGD(1), PGM1(4), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3), TKTL1(5), TKTL2(7)	8185100	67	38	67	21	27	29	8	0	3	0	0.81	0.93
538	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(6), NR3C1(4), PPARG(1), RXRA(1)	1886864	13	9	13	10	1	6	3	0	3	0	0.82	0.93
539	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(2), IL22RA1(1), JAK1(4), JAK2(9), JAK3(8), STAT1(6), STAT3(2), STAT5B(3), TYK2(1)	6252292	38	24	37	17	12	12	7	0	5	2	0.82	0.93
540	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(1), CD3D(1), CD3G(2), CD4(2), CD58(2), IL3(3), IL6(2), IL8(1), KITLG(2)	2136968	19	11	18	8	6	9	3	0	1	0	0.82	0.93
541	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(4), AASDHPPT(3), AASS(9), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(5), HADHA(3), PLOD1(4), PLOD2(5), PLOD3(4), SDS(2), SHMT1(2), SHMT2(2), TMLHE(3)	12250168	99	40	97	25	36	28	18	2	15	0	0.82	0.93
542	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(6), ATF3(1), CYR61(2), HBEGF(1), IFNG(1), IFRD1(5), IL1A(1), IL1R1(4), MYOG(1), NR4A3(4), WDR1(3)	3716372	30	16	30	6	9	11	7	0	3	0	0.82	0.94
543	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAR2B(3)	3412280	18	14	18	12	6	6	0	0	6	0	0.83	0.94
544	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), ASCC3(19), ATP13A2(3), DDX18(3), DDX19A(3), DDX23(4), DDX4(3), DDX41(2), DDX47(3), DDX50(3), DDX52(2), DDX54(5), DDX55(3), DDX56(5), DHFR(1), DHX58(3), ENTPD7(4), EP400(20), ERCC2(4), ERCC3(7), GGH(1), IFIH1(5), MOV10L1(13), RAD54B(8), RAD54L(3), RUVBL2(1), SETX(20), SKIV2L2(3), SMARCA2(10), SMARCA5(7)	21329036	173	52	170	42	66	47	36	0	23	1	0.83	0.94
545	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(2), CASP7(1), DFFA(3), DFFB(2), GZMB(2), HMGB1(1), HMGB2(1), TOP2A(5), TOP2B(9)	3488500	26	14	25	6	4	12	7	0	3	0	0.83	0.94
546	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), G6PD(3), GPI(2), H6PD(4), PFKM(4), PFKP(2), PGD(1), PGM1(4), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3)	6863396	52	34	52	17	21	25	5	0	1	0	0.83	0.94
547	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), CABIN1(11), CAMK1(3), CAMK1G(5), HDAC5(2), IGF1(2), IGF1R(8), INSR(6), MAP2K6(3), MAPK14(3), MAPK7(3), MEF2A(4), MEF2C(9), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(3), PPP3CB(5), PPP3CC(4), SYT1(1), YWHAH(1)	10372972	83	40	82	38	39	21	11	0	12	0	0.83	0.94
548	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(18), ACACB(15), FASN(1), MCAT(1), OLAH(1), OXSM(5)	5111576	41	22	40	11	16	13	8	0	4	0	0.83	0.94
549	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(5), FUCA1(3), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), HGSNAT(6), HPSE(2), HPSE2(12), IDS(2), IDUA(1), LCT(20), MAN2B1(5), MAN2B2(1), MAN2C1(6), MANBA(7), NAGLU(4), NEU1(1), NEU2(1), NEU3(1), SPAM1(4)	11667372	102	38	100	35	37	28	24	1	12	0	0.84	0.94
550	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(5), ACTN2(8), ACTN3(3), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(6), ITGB3(9), PTK2(5), SPTAN1(13), SRC(3), TLN1(7)	9787700	70	38	70	31	34	22	10	0	3	1	0.84	0.94
551	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), KHK(1), LCT(20), MPI(1), PGM1(4), PYGL(2), PYGM(4), TPI1(1), TREH(2)	4563208	41	26	41	15	18	12	11	0	0	0	0.84	0.94
552	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ENPP1(4), ENPP3(4), FLAD1(1), TYR(3)	3277220	21	14	20	12	8	5	6	0	1	1	0.84	0.94
553	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT1E1(2), SULT2A1(2), SUOX(2)	2042004	14	8	14	1	5	5	1	0	3	0	0.84	0.94
554	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(1), CTSD(3), GREB1(12), HSPB2(2), MTA1(1), MTA3(1), PDZK1(1), TUBA8(2)	3242564	23	16	23	10	8	8	4	0	3	0	0.85	0.94
555	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(2), ENPP1(4), ENPP3(4), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(3), NNT(3), NT5E(3), NT5M(1), QPRT(1)	4937944	35	19	35	17	11	13	6	0	5	0	0.86	0.95
556	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	15	AKT1(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), IGF1(2), IGF1R(8), INPPL1(4), PDK2(2), PDPK1(1), PPP2CA(1), RPS6KB1(3)	4823320	30	23	30	13	12	8	6	0	4	0	0.86	0.95
557	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(2), CAPN2(6), CAPNS1(1), CAPNS2(1), EGF(3), EGFR(11), ITGA1(3), ITGB1(6), MAPK1(2), MAPK3(3), MYL2(1), MYLK(14), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTK2(5), TLN1(7)	11184912	82	40	82	25	34	24	18	0	6	0	0.86	0.95
558	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	15	BCAT1(1), BCAT2(1), COASY(1), DPYS(7), ENPP1(4), ENPP3(4), ILVBL(2), PANK1(2), PANK3(3), PANK4(1), PPCS(2), UPB1(5), VNN1(6)	5083212	39	22	38	15	10	18	8	0	3	0	0.87	0.96
559	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), FPGT(5), GCK(2), GMDS(1), GMPPA(7), HK1(6), HK2(3), HK3(5), KHK(1), MPI(1), PFKFB1(7), PFKFB4(2), PFKM(4), PFKP(2), PMM1(3), SORD(2), TPI1(1)	8156180	67	37	67	25	25	32	7	0	3	0	0.87	0.96
560	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	18	AKT1(2), EIF4G1(9), EIF4G2(7), EIF4G3(11), GHR(6), IRS1(8), MAPK1(2), MAPK14(3), MAPK3(3), MKNK1(1), PABPC1(3), PDK2(2), PDPK1(1), PRKCA(4), RPS6KB1(3)	7596940	65	29	65	20	18	24	16	0	7	0	0.87	0.96
561	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(2), AKT2(6), AKT3(1), BRD4(4), CAP1(1), CBL(5), CDC42(1), CDKN2A(1), F2RL2(3), FLOT1(3), GRB2(3), GSK3A(2), IGFBP1(2), INPPL1(4), IRS1(8), IRS4(15), LNPEP(8), MAPK1(2), MAPK3(3), PARD3(7), PARD6A(2), PDK1(2), PIK3CD(3), PPYR1(4), PTPN1(5), RAF1(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SERPINB6(2), SHC1(3), SLC2A4(4), SORBS1(11), SOS1(7), SOS2(11), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	17858512	167	51	163	51	59	58	30	3	17	0	0.88	0.96
562	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATR(17), BRCA1(6), BRCA2(22), CHEK1(1), CHEK2(1), FANCA(7), FANCC(3), FANCD2(11), FANCF(2), FANCG(4), HUS1(1), MRE11A(8), RAD1(1), RAD17(4), RAD50(11), TREX1(2)	12495808	101	32	101	16	29	35	23	0	14	0	0.88	0.97
563	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(6), DUSP1(2), IKBKAP(2), IKBKB(4), MAP3K1(8), MAP3K14(3), NFKB1(6), RELA(2), RIPK1(2), TANK(6), TNFAIP3(3), TRAF1(2), TRAF2(1), TRAF3(6)	7611944	53	26	52	18	25	13	9	1	5	0	0.89	0.97
564	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), CHUK(6), FOS(1), IKBKB(4), IRAK1(1), LY96(2), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K7(4), MAPK14(3), MAPK8(7), MYD88(2), NFKB1(6), PPARA(1), RELA(2), TIRAP(1), TLR10(4), TLR2(6), TLR3(5), TLR4(10), TLR6(2), TLR7(7), TLR9(7), TOLLIP(1), TRAF6(4)	12078284	107	38	107	33	35	32	27	3	9	1	0.89	0.97
565	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(8), BCL2(1), BID(1), BIRC2(4), BIRC3(7), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP9(2), CFLAR(3), CHUK(6), DFFA(3), DFFB(2), GAS2(2), MAP3K14(3), NFKB1(6), RELA(2), RIPK1(2), SPTAN1(13), TNFRSF10A(3), TNFRSF10B(6), TNFSF10(1), TNFSF12(2), TRADD(1), TRAF2(1)	10995520	86	37	86	33	32	31	13	0	9	1	0.89	0.97
566	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	11	BCAT1(1), COASY(1), DPYS(7), ENPP1(4), ENPP3(4), PANK1(2), PANK3(3), PANK4(1), PPCS(2), UPB1(5)	3918016	30	16	29	9	6	15	6	0	3	0	0.89	0.97
567	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(1), SRP19(1), SRP54(3), SRP68(4), SRP72(4), SRPR(1)	2528892	18	12	18	5	6	8	2	1	1	0	0.89	0.97
568	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(3), CAMK1G(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CAMKK1(1), CAMKK2(1), CREB1(1), SYT1(1)	3947040	23	15	23	14	7	8	6	0	2	0	0.90	0.97
569	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GOT1(6), GOT2(1), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHAL6B(2), LDHB(3), LDHC(2), MDH1(1), MDH2(1), PC(6), PCK1(3), PDHA1(5), PDHA2(8), PDHB(2), PDHX(2), PFKL(1), PFKM(4), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(7), PKM2(2), TNFAIP1(3), TPI1(1)	14078660	116	44	113	47	47	42	16	0	11	0	0.90	0.97
570	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(4), CDKN2A(1), MDM2(4), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), RB1(7)	5173112	38	22	38	9	11	12	12	0	2	1	0.90	0.97
571	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	19	AKT1(2), BCL2(1), BCR(7), CRKL(2), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), RAF1(6), SOS1(7), STAT1(6), STAT5B(3)	7814520	69	30	68	15	25	20	17	1	4	2	0.90	0.97
572	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	8	EIF2AK3(2), EIF2AK4(6), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF5(3)	3594112	18	13	18	5	3	5	7	0	3	0	0.90	0.97
573	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST12(3), CHST13(2), PAPSS1(2), PAPSS2(4), SULT1A1(2), SULT1A2(1), SULT1E1(2), SULT2A1(2), SULT2B1(1), SUOX(2)	3092160	25	14	25	5	10	8	4	0	3	0	0.90	0.97
574	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BAG4(2), BIRC2(4), BIRC3(7), CASP3(2), CFLAR(3), MAP3K3(3), MAP3K7(4), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NR2C2(4), RALBP1(6), RIPK1(2), TNFAIP3(3), TNFRSF1A(1), TRADD(1), TRAF2(1)	8346188	56	29	56	14	20	17	14	1	4	0	0.91	0.98
575	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(5), MBTPS1(8), SCAP(2), SREBF1(1), SREBF2(2)	3992908	19	14	19	12	7	6	3	0	3	0	0.91	0.98
576	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(2), APAF1(8), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), CASP3(2), CASP6(2), CASP7(1), CASP9(2), PRKCA(4), PTK2(5), STAT1(6), TLN1(7)	6946508	44	27	44	16	15	15	9	0	5	0	0.91	0.98
577	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(1), CDC42(1), CREB1(1), DAXX(1), GRB2(3), HSPB2(2), MAP2K6(3), MAP3K1(8), MAP3K5(6), MAP3K7(4), MAP3K9(4), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MAX(1), MEF2A(4), MEF2C(9), MEF2D(1), MKNK1(1), PLA2G4A(8), RIPK1(2), RPS6KA5(6), SHC1(3), STAT1(6), TGFB1(1), TGFB2(9), TGFBR1(9), TRADD(1), TRAF2(1)	12227444	103	33	99	33	38	28	23	0	14	0	0.92	0.98
578	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(3), DDX20(4), E2F4(1), ETS1(1), ETS2(3), ETV3(1), FOS(1), HDAC2(2), HDAC5(2), NCOR2(2), RBL1(5), RBL2(8), SIN3A(10), SIN3B(4)	8946576	49	25	48	27	17	15	9	0	8	0	0.92	0.98
579	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(8), CYB5R3(1), GCK(2), GFPT1(4), GNE(2), GNPDA2(1), HEXB(3), HK1(6), HK2(3), HK3(5), PGM3(5), RENBP(1)	5735140	41	25	40	13	13	19	8	0	1	0	0.92	0.98
580	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(3), GLB1(3), HEXB(3), LCT(20), MAN2B1(5), MAN2B2(1), MAN2C1(6), MANBA(7), NEU1(1), NEU2(1), NEU3(1)	6812068	56	29	56	21	21	16	15	0	4	0	0.92	0.98
581	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	ARHGDIB(3), BAG4(2), CASP2(4), CASP3(2), CRADD(2), DFFA(3), DFFB(2), LMNB1(4), LMNB2(1), MADD(14), MAP3K1(8), MAP3K7(4), MAPK8(7), PAK1(5), PAK2(3), PRKDC(18), RB1(7), RIPK1(2), SPTAN1(13), TNFRSF1A(1), TRADD(1), TRAF2(1)	12827132	107	39	106	40	32	28	27	2	16	2	0.92	0.98
582	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	APAF1(8), ARHGDIB(3), BAG4(2), BCL2(1), BID(1), BIRC2(4), BIRC3(7), CASP2(4), CASP3(2), CASP6(2), CASP7(1), CASP9(2), CFLAR(3), CHUK(6), CRADD(2), DAXX(1), DFFA(3), DFFB(2), LMNB1(4), LMNB2(1), MAP3K1(8), MAP3K14(3), MAP3K5(6), MAPK8(7), MDM2(4), NFKB1(6), NUMA1(10), PAK2(3), PRKCD(3), PRKDC(18), PSEN1(3), PSEN2(2), PTK2(5), RASA1(9), RB1(7), RELA(2), RIPK1(2), SPTAN1(13), TNFRSF1A(1), TRADD(1), TRAF1(2), TRAF2(1)	23264096	175	52	174	54	57	49	45	1	21	2	0.93	0.98
583	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(1), RPL10A(2), RPL10L(2), RPL11(1), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL24(1), RPL28(2), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL6(3), RPL7(1), RPL9(4), RPS11(1), RPS13(1), RPS15A(1), RPS16(2), RPS18(2), RPS2(1), RPS20(1), RPS23(4), RPS3(2), RPS9(2), RPSA(1)	7558400	48	28	47	14	14	13	16	1	4	0	0.93	0.98
584	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(3), ARFGEF2(8), CLTA(2), COPA(2), GBF1(12), GPLD1(6), KDELR1(2), KDELR2(1), KDELR3(1)	5467848	38	22	37	15	16	9	8	1	4	0	0.94	0.99
585	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), B4GALT1(6), B4GALT2(3), G6PC(4), G6PC2(1), GALE(1), GALK2(3), GALT(2), GANC(3), GCK(2), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(5), HSD3B7(2), LALBA(1), LCT(20), MGAM(13), PFKL(1), PFKM(4), PFKP(2), PGM1(4), PGM3(5), RDH11(1), RDH12(3), RDH13(1), UGP2(7)	13025704	113	43	113	38	50	39	20	0	4	0	0.94	0.99
586	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(5), ARSD(3), ARSE(2), ASAH1(3), GAL3ST1(2), GALC(1), GLA(4), GLB1(3), LCT(20), NEU1(1), NEU2(1), NEU3(1), PPAP2B(1), SMPD1(6), SPTLC1(4), SPTLC2(2), UGCG(2)	8022488	62	30	62	23	24	18	14	2	4	0	0.94	0.99
587	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), XYLT1(6), XYLT2(2)	2235840	16	11	15	13	7	4	2	1	2	0	0.95	0.99
588	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), XYLT1(6), XYLT2(2)	2235840	16	11	15	13	7	4	2	1	2	0	0.95	0.99
589	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), BAD(1), BCL2(1), BCL2L1(1), CBL(5), CFLAR(3), CRKL(2), FOS(1), GRB2(3), IL2RA(2), IL2RB(2), IRS1(8), JAK1(4), JAK3(8), MAPK1(2), MAPK3(3), NMI(2), PTPN6(4), RAF1(6), RPS6KB1(3), SHC1(3), SOS1(7), STAT5B(3), SYK(3)	10852692	79	34	76	29	27	31	10	0	11	0	0.95	1.00
590	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	9	ADAM17(7), AXIN1(2), BTRC(5), DLL1(4), FZD1(1), PSEN1(3), WNT1(1)	4003612	23	15	23	10	10	3	4	0	6	0	0.95	1.00
591	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(5), NR1H3(4), NR1H4(2), RXRA(1)	1809836	13	10	13	7	6	3	3	1	0	0	0.96	1.00
592	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(3), HMGCR(3), IDI1(1), LSS(2), MVK(1), NQO1(1), NQO2(1), PMVK(1), SC5DL(3), SQLE(2)	3786500	20	16	20	8	10	5	4	0	1	0	0.96	1.00
593	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), KEAP1(3), MAPK1(2), MAPK14(3), MAPK8(7), NFE2L2(4), PRKCA(4)	2938936	25	13	25	3	6	10	7	1	1	0	0.97	1.00
594	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(2), BDH1(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(3), OXCT2(1)	2448320	11	10	11	5	6	4	1	0	0	0	0.97	1.00
595	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(3), GGCX(5), GGPS1(1), HMGCR(3), IDI1(1), IDI2(1), LSS(2), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC4MOL(1), SC5DL(3), SQLE(2)	6569804	39	23	39	14	15	14	6	0	4	0	0.97	1.00
596	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(11), MAP2K1(4), MAP3K1(8), MAPK14(3), NCOR2(2), RXRA(1), THRA(2), THRB(4)	5849792	38	22	38	15	18	10	8	0	2	0	0.97	1.00
597	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(1), EEF1B2(1), EEF1G(1), EEF2(3), EEF2K(1), EIF2AK1(6), EIF2AK2(1), EIF2AK3(2), EIF2B1(2), EIF2B2(1), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF4EBP2(1), EIF4G1(9), EIF4G3(11), EIF5(3), EIF5A(2), EIF5B(4), ETF1(5), KIAA0664(4), PABPC1(3), PABPC3(6), PAIP1(4), SLC35A4(2)	14639220	82	39	81	25	26	20	21	2	13	0	0.97	1.00
598	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(2), BIRC3(7), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(1)	2393432	14	11	14	6	5	5	3	0	1	0	0.97	1.00
599	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(6), DNAJC3(1), EIF2S2(1), MAP3K14(3), NFKB1(6), RELA(2)	3150696	19	9	19	7	11	2	4	0	2	0	0.98	1.00
600	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(6), IFNG(1), IKBKB(4), IL2(4), IL4(3), MAP3K1(8), MAP3K5(6), MAP4K5(2), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), TNFRSF9(3), TRAF2(1)	6686712	57	23	57	15	21	23	10	1	2	0	0.98	1.00
601	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(3), HMGCR(3), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(2), PMVK(1), SC4MOL(1), SC5DL(3), SQLE(2)	4506660	25	16	25	10	11	7	5	0	2	0	0.98	1.00
602	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1)	4496660	28	16	28	4	10	9	7	1	1	0	0.98	1.00
603	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(6), IKBKB(4), IL1A(1), IL1R1(4), IRAK1(1), MAP3K1(8), MAP3K14(3), MAP3K7(4), MYD88(2), NFKB1(6), RELA(2), RIPK1(2), TLR4(10), TNFAIP3(3), TNFRSF1A(1), TRADD(1), TRAF6(4)	8211660	62	25	62	18	23	19	14	0	6	0	0.98	1.00
604	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(7), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(5), HDAC3(2), NCOA1(8), NCOA2(7), NCOA3(11), NCOR2(2), POLR2A(6), RXRA(1), TBP(1)	8507856	58	30	58	21	19	22	13	1	3	0	0.99	1.00
605	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLUD1(2), OAT(1)	1833156	7	6	7	3	4	1	2	0	0	0	0.99	1.00
606	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), FPGT(5), FUK(1), GMDS(1), GMPPA(7), HK1(6), HK2(3), HK3(5), HSD3B7(2), KHK(1), LHPP(2), MPI(1), MTMR1(5), MTMR2(2), MTMR6(4), PFKFB1(7), PFKFB4(2), PFKL(1), PFKM(4), PFKP(2), PHPT1(1), PMM1(3), RDH11(1), RDH12(3), RDH13(1), SORD(2), TPI1(1), TSTA3(1)	12661132	89	40	89	39	36	39	9	0	5	0	0.99	1.00
607	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	10	APP(1), CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(4), MAPT(5), PPP2CA(1)	2891456	18	12	18	8	9	4	3	1	1	0	0.99	1.00
608	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(2), RDH11(1), RDH12(3), RDH13(1)	1627788	8	6	8	4	4	4	0	0	0	0	0.99	1.00
609	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	37	APAF1(8), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(4), BIRC3(7), CASP2(4), CASP3(2), CASP6(2), CASP7(1), CASP9(2), FAS(2), FASLG(1), GZMB(2), MAP3K1(8), MAP3K14(3), MDM2(4), NFKB1(6), PARP1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF1(2), TRAF2(1)	11353428	75	32	75	30	30	21	17	0	7	0	0.99	1.00
610	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(6), PGAP1(8), PIGA(1), PIGB(2), PIGG(3), PIGK(4), PIGM(3), PIGN(2), PIGO(3), PIGQ(1), PIGS(2), PIGT(3), PIGU(1), PIGV(2), PIGW(1), PIGX(4)	8312940	49	22	48	19	15	16	12	0	6	0	1.00	1.00
611	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(1), MST1R(1)	2077248	5	5	5	4	3	2	0	0	0	0	1.00	1.00
612	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(4), BRCA1(6), CDKN1A(1), CHEK1(1), CHEK2(1), MAPK8(7), MDM2(4), MRE11A(8), NFKB1(6), RAD50(11), RBBP8(2), RELA(2)	7606680	53	20	53	11	16	18	14	1	4	0	1.00	1.00
613	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	17	AKT1(2), EIF4B(2), EIF4G1(9), EIF4G2(7), EIF4G3(11), MKNK1(1), PDK2(2), PDPK1(1), PPP2CA(1), RPS6KB1(3), TSC1(4), TSC2(2)	7418424	45	21	45	20	16	12	11	0	6	0	1.00	1.00
614	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(1), B3GAT3(1), CHPF(3), CHST11(3), CHST12(3), CHST13(2), CHST14(1), CHSY1(5), DSE(3), UST(1), XYLT1(6), XYLT2(2)	4799936	31	18	31	24	11	12	6	0	2	0	1.00	1.00
615	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), DHFR(1), GGH(1)	2173660	7	7	7	1	2	4	1	0	0	0	1.00	1.00
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		169792	0	0	0	1	0	0	0	0	0	0	1.00	1.00
