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MAF used for this analysis:SKCM.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 243
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 243. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| NRAS | 18615 | 0 | 1 | 70 | 0 | 0 | 0 |
| BRAF | 66555 | 0 | 2 | 138 | 0 | 3.5e-241 | 3.3e-237 |
| CDKN2A | 15300 | 0 | 1 | 32 | 21 | 7.9e-69 | 4.9e-65 |
| RTL1 | 13515 | 0 | 3 | 13 | 0 | 1.1e-33 | 5.3e-30 |
| DNAH6 | 41055 | 0 | 1 | 17 | 1 | 3.5e-31 | 1.3e-27 |
| EYS | 57375 | 0 | 1 | 10 | 0 | 9.6e-27 | 3e-23 |
| CCNE2 | 45645 | 0 | 2 | 14 | 2 | 5.9e-22 | 1.6e-18 |
| SPRR3 | 12750 | 0 | 3 | 12 | 1 | 8.6e-22 | 2e-18 |
| INTS8 | 94095 | 0 | 1 | 24 | 2 | 1.8e-21 | 3.7e-18 |
| SMR3A | 7140 | 0 | 2 | 8 | 0 | 1.1e-20 | 2.2e-17 |
| CDC123 | 34935 | 0 | 0 | 8 | 2 | 9.6e-20 | 1.6e-16 |
| NAP1L4 | 36975 | 0 | 0 | 14 | 2 | 1.5e-19 | 2.4e-16 |
| NOTCH2 | 197370 | 0 | 9 | 38 | 3 | 2.2e-19 | 3.3e-16 |
| ADAM30 | 73950 | 0 | 11 | 38 | 3 | 7.8e-19 | 1.1e-15 |
| PTEN | 41055 | 0 | 0 | 23 | 14 | 1.1e-18 | 1.4e-15 |
| PRC1 | 59415 | 0 | 2 | 17 | 1 | 7.9e-17 | 9.3e-14 |
| TAF1A | 46410 | 0 | 0 | 14 | 0 | 1e-16 | 1.2e-13 |
| TP53 | 32130 | 0 | 1 | 40 | 16 | 6.7e-16 | 6.8e-13 |
| PPT2 | 26775 | 0 | 2 | 8 | 0 | 6.9e-16 | 6.8e-13 |
| DEFB115 | 8670 | 0 | 2 | 7 | 1 | 5.4e-15 | 5e-12 |
| LIPF | 40545 | 0 | 5 | 14 | 0 | 5.9e-15 | 5.3e-12 |
| IDH1 | 40800 | 0 | 1 | 14 | 0 | 6.6e-14 | 5.7e-11 |
| ARID2 | 154530 | 0 | 4 | 46 | 26 | 3.7e-13 | 3e-10 |
| TBC1D3 | 10965 | 2 | 0 | 7 | 0 | 3.8e-13 | 3e-10 |
| TAX1BP1 | 76755 | 0 | 2 | 14 | 2 | 1.6e-12 | 1.2e-09 |
| CLCC1 | 56355 | 0 | 1 | 15 | 2 | 1.8e-12 | 1.3e-09 |
| PPP6C | 29325 | 0 | 2 | 21 | 5 | 3.8e-12 | 2.7e-09 |
| DISP1 | 141270 | 0 | 9 | 41 | 5 | 5.1e-12 | 3.5e-09 |
| IVL | 22185 | 0 | 4 | 12 | 0 | 6.7e-12 | 4.3e-09 |
| NBPF7 | 39780 | 0 | 1 | 16 | 1 | 6.8e-12 | 4.3e-09 |
| STK31 | 103530 | 0 | 4 | 39 | 2 | 1.2e-11 | 7.5e-09 |
| F2RL1 | 37230 | 0 | 5 | 15 | 1 | 2.6e-11 | 1.5e-08 |
| COPG2 | 37230 | 0 | 1 | 12 | 6 | 2.8e-11 | 1.6e-08 |
| DPY19L4 | 76245 | 0 | 2 | 20 | 6 | 8.9e-11 | 4.8e-08 |
| PRB1 | 10200 | 0 | 4 | 30 | 1 | 9e-11 | 4.8e-08 |
