rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(5), CD4(5), HLA-DRA(3), HLA-DRB1(1), IL1B(2), IL5(1), IL5RA(3)	761782	21	19	20	4	15	1	0	4	1	0	0.0101	0.0304	1.000
2	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(7), HSD17B2(3), HSD17B4(4), HSD3B1(3), HSD3B2(3)	1145924	22	20	21	3	16	0	2	2	1	1	0.00703	0.0342	1.000
3	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(3), DCN(7), KERA(2), LUM(4)	506483	16	13	16	4	11	2	0	0	3	0	0.0323	0.0600	1.000
4	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(5), HLA-DRA(3), HLA-DRB1(1)	334543	9	8	9	0	5	1	0	3	0	0	0.0192	0.0774	1.000
5	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), FOSB(2), GRIA2(14)	526332	17	13	17	4	12	2	1	1	1	0	0.0869	0.0794	1.000
6	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(4), GOT1(3), GOT2(1), TAT(4), TYR(4)	673736	16	13	16	3	10	2	1	1	2	0	0.0589	0.106	1.000
7	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(5), CD80(3), HLA-DRA(3), HLA-DRB1(1), IL10(1)	562026	13	9	13	1	5	1	1	6	0	0	0.0360	0.129	1.000
8	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(3), PIK3R1(3), PLCB1(16), PLCG1(6), PRKCA(2), VAV1(5)	1832035	38	28	38	6	24	1	2	6	4	1	0.00265	0.144	1.000
9	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	102790	3	3	3	1	2	0	1	0	0	0	0.541	0.162	1.000
10	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(8)	260514	10	6	10	2	6	1	1	2	0	0	0.159	0.176	1.000
11	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(2), CSAD(2), GAD1(5), GAD2(4), GGT1(2)	808113	17	14	17	3	12	3	0	1	1	0	0.0215	0.208	1.000
12	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(1), NFKBIA(1), PLCB1(16), PRKCA(2), RELA(2)	1171951	23	17	23	3	14	1	2	3	3	0	0.0152	0.244	1.000
13	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(1), TAT(4)	377080	8	6	8	0	5	1	1	1	0	0	0.0282	0.246	1.000
14	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD4(5), FYN(1), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(16)	1262907	27	20	26	6	17	4	1	4	1	0	0.0259	0.284	1.000
15	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(5), HLA-DRA(3), HLA-DRB1(1), IL3(2), IL5(1)	432318	13	12	13	4	10	0	0	3	0	0	0.108	0.287	1.000
16	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(3), BCMO1(4)	559215	7	7	7	1	5	1	0	1	0	0	0.136	0.404	1.000
17	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(2)	220911	2	2	2	0	0	1	0	1	0	0	0.634	0.458	1.000
18	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(2), ACPP(3), ENPP1(4), ENPP3(4), FLAD1(3), TYR(4)	1383691	24	19	24	3	14	3	0	4	3	0	0.0159	0.473	1.000
19	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(3), NR0B2(1), NR1H3(2), NR1H4(5)	776226	11	10	11	2	5	2	2	1	1	0	0.0813	0.479	1.000
20	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5)	809092	27	21	25	9	21	3	1	2	0	0	0.145	0.513	1.000
21	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(3)	441175	5	5	5	2	2	0	1	1	1	0	0.548	0.523	1.000
22	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOB(2), ALDOC(2)	563762	6	5	6	1	3	2	0	0	1	0	0.165	0.542	1.000
23	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	73504	1	1	1	0	1	0	0	0	0	0	0.677	0.545	1.000
24	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP2(2), ACP5(2), ACP6(2), ACPP(3), ALPI(4), ALPL(1), ALPP(2), ALPPL2(1), CMBL(1), CYP3A4(8), CYP3A43(7), CYP3A5(5), CYP3A7(1), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), PON1(3), PON3(1)	2560723	52	34	50	5	40	6	2	3	1	0	3.84e-07	0.561	1.000
25	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(5), NR1I3(2), PTGS1(7), PTGS2(2)	768046	21	15	21	7	15	2	1	2	1	0	0.0796	0.562	1.000
26	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(1), CYP2A6(3), CYP2A7(3), NAT1(1), NAT2(5), XDH(8)	1144988	26	20	24	9	17	2	4	1	2	0	0.0341	0.568	1.000
27	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(5), CD8A(1), CSF1(4), EPO(2), IL3(2), IL5(1), IL7(2)	860920	17	13	17	4	13	1	0	1	2	0	0.0198	0.569	1.000
28	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1), SLPI(1)	245541	2	2	2	0	0	0	0	2	0	0	0.702	0.599	1.000
29	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1), ECHS1(1), HADHA(4)	785992	6	6	6	1	1	2	0	3	0	0	0.448	0.618	1.000
30	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(5), HDC(6), TH(4), TPH1(2)	846272	22	18	22	8	19	0	0	2	1	0	0.0727	0.625	1.000
31	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	EPO(2), FLT3(10), IGF1(5), IL1A(1), IL3(2), TGFB3(2)	1174354	22	17	22	6	14	1	1	4	2	0	0.0653	0.653	1.000
32	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD4(5)	457899	5	4	5	2	3	1	0	1	0	0	0.450	0.674	1.000
33	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(1), EHHADH(2), GCDH(3), HADHA(4), SDHB(1)	1114627	12	10	12	3	8	2	0	2	0	0	0.179	0.708	1.000
34	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(6), CD4(5), CD8A(1), IL3(2)	876869	14	10	13	3	12	1	0	1	0	0	0.0496	0.714	1.000
35	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(1), IFNGR2(2), JAK1(2), JAK2(2)	1167190	8	8	8	1	2	0	0	2	4	0	0.442	0.715	1.000
36	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	236827	2	2	2	0	2	0	0	0	0	0	0.344	0.715	1.000
37	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(2), NFKB1(1), NOX1(3), RELA(2), XDH(8)	1409482	17	15	17	3	10	3	2	2	0	0	0.0315	0.721	1.000
38	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(4)	690225	8	8	8	3	3	2	0	3	0	0	0.500	0.722	1.000
39	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), JUN(1), KEAP1(1), MAPK1(1), MAPK14(2), NFE2L2(1), PRKCA(2)	1258819	9	9	9	1	4	0	0	2	3	0	0.187	0.728	1.000
40	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(2), STX1A(1)	468277	4	4	4	1	3	0	0	0	1	0	0.372	0.739	1.000
41	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(7), RANGAP1(1)	1216644	9	9	9	1	4	1	1	2	1	0	0.215	0.770	1.000
42	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(3), FUT1(1), FUT3(1), FUT5(3), FUT6(3), ST3GAL3(1)	710421	12	11	12	5	7	1	0	1	3	0	0.188	0.771	1.000
43	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), ESR2(3), PDE1A(13), PDE1B(5), PLCB1(16), PLCB2(1), TRH(3), VIP(1)	1567771	44	25	43	12	33	1	2	6	2	0	0.00747	0.785	1.000
44	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(1), CBS(1), CTH(1), MUT(2)	728346	6	6	6	2	4	1	1	0	0	0	0.483	0.792	1.000
45	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(2), IFNAR1(1), IFNAR2(5), IFNB1(2), NFKB1(1), RELA(2), TNFRSF11A(2), TNFSF11(2), TRAF6(1)	1581441	19	13	19	2	8	2	0	6	3	0	0.0235	0.803	1.000
46	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), HTR2C(3), PLCB1(16), TUB(2)	1020010	22	14	22	4	16	0	1	3	2	0	0.0202	0.804	1.000
47	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(1), ME1(8), PC(7), PDHA1(1)	1329486	19	13	18	3	9	0	2	6	2	0	0.0299	0.813	1.000
48	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(4), PARK2(2), SNCA(1), SNCAIP(14), UBE2F(1), UBE2L6(1)	919757	23	18	22	8	14	3	1	2	3	0	0.232	0.816	1.000
49	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), GPR161(1), GPR171(4), GPR18(3), GPR39(2), GPR45(1), GPR65(4), GPR68(1), GPR75(2)	1395089	20	18	20	6	11	0	2	3	4	0	0.0308	0.820	1.000
50	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(5), GLS(1), GOT1(3)	1098641	12	11	12	3	6	1	2	3	0	0	0.237	0.826	1.000
51	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(3), RECK(8), TIMP3(2), TIMP4(3)	1060539	16	14	16	4	10	0	1	4	1	0	0.149	0.842	1.000
52	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(2), ACP6(2), ACPP(3), ENPP1(4), ENPP3(4), FLAD1(3), MTMR1(2), MTMR2(1), TYR(4)	2143531	29	21	29	3	16	3	2	5	3	0	0.00514	0.843	1.000
53	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(3), AASS(2)	669262	6	6	6	1	5	0	0	1	0	0	0.324	0.851	1.000
54	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), HMGCS1(1), HMGCS2(5), OXCT1(2), OXCT2(1)	1021301	10	7	10	2	5	1	0	3	1	0	0.205	0.863	1.000
55	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB11A(1), RAB1A(1), RAB5A(1)	600876	3	3	3	1	1	1	1	0	0	0	0.569	0.866	1.000
56	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), CHUK(1), GH1(2), GHR(8), NFKB1(1), NFKBIA(1), PDPK1(1), PIK3CA(3), PIK3R1(3), RELA(2)	1994562	25	19	24	6	13	2	1	6	2	1	0.122	0.867	1.000
57	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(15), NRG2(3), NRG3(5), PRKCA(2), PSEN1(1)	1267339	27	21	26	8	18	1	1	3	4	0	0.136	0.870	1.000
58	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(4), HSD17B10(2), HSD17B4(4), SIRT5(1), SIRT7(1), VNN2(1)	1688436	17	16	17	4	8	3	2	4	0	0	0.162	0.874	1.000
59	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), JUN(1), MAP2K1(3), MAPK1(1), NFKB1(1), NFKBIA(1), PLCB1(16), PRKCA(2), RAF1(3), RELA(2)	2221062	34	24	31	9	21	2	3	5	3	0	0.0306	0.882	1.000
60	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(1), DPYD(17), DPYS(12), ENPP1(4), ENPP3(4), PANK2(1), PANK3(1), PANK4(3), UPB1(2)	1984906	49	30	47	11	31	3	2	9	4	0	0.0173	0.885	1.000
61	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(2), MTMR2(1), TPK1(3)	914167	6	5	5	0	2	0	1	1	1	1	0.178	0.886	1.000
62	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), DPM2(1), KLK2(1), MAP2K1(3), MAP2K2(2), MAPK1(1), RAF1(3)	1153485	12	12	10	4	6	0	1	3	2	0	0.325	0.887	1.000
63	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(4), LDLR(3), LPL(1)	765704	8	7	8	0	6	0	0	1	1	0	0.0225	0.888	1.000
64	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), OXCT1(2)	481726	3	3	3	1	2	0	0	0	1	0	0.572	0.893	1.000
65	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(5), SRP19(3), SRP54(1), SRP68(1), SRPR(1)	1092702	12	9	12	4	3	0	2	4	3	0	0.726	0.898	1.000
66	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(5), CSF1(4), HLA-DRA(3), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(1), IL10(1), IL15(1), IL1A(1), IL3(2), IL5(1), IL7(2), PDGFA(1), TGFB3(2)	1869941	28	17	28	6	16	1	1	4	6	0	0.00465	0.901	1.000
67	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(8), CCNE1(1), CCNE2(5), E2F2(1), PRB1(7)	1106279	22	16	21	5	15	0	1	6	0	0	0.120	0.906	1.000
68	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(2), AASDHPPT(3), AASS(2)	990730	8	7	8	1	6	0	0	1	1	0	0.198	0.913	1.000
69	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), UGDH(1), UXS1(2)	551755	4	4	4	2	3	0	0	0	1	0	0.612	0.914	1.000
70	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(1), GOT1(3), GOT2(1), LDHA(1), LDHB(2), LDHC(2)	980656	14	11	14	3	9	0	3	2	0	0	0.102	0.915	1.000
71	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(2), LARS(3), PDHA1(1), PDHA2(6)	1441176	16	14	16	2	13	1	0	1	1	0	0.0330	0.924	1.000
72	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(1), HSD3B7(2), RDH11(1), RDH12(1), RDH13(1)	686159	9	7	9	4	6	1	0	1	1	0	0.288	0.924	1.000
73	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(3), MBTPS1(4), MBTPS2(1), SCAP(5), SREBF1(1), SREBF2(1)	1686111	16	14	16	1	9	0	2	4	1	0	0.0115	0.924	1.000
74	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	302966	1	1	1	1	1	0	0	0	0	0	0.835	0.926	1.000
75	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(1), GOT1(3), GOT2(1), PAH(3), TAT(4), YARS2(1)	1244837	16	13	15	4	12	2	1	1	0	0	0.0678	0.927	1.000
76	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), DPM2(1), GRB2(1), KLK2(1), NTRK1(5), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), SOS1(3)	2212990	28	21	28	7	14	3	1	6	3	1	0.124	0.927	1.000
77	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	9	ECHS1(1), HADHA(4), HSD17B10(2), HSD17B4(4), MECR(1), PPT1(2)	1116287	14	13	14	5	6	4	2	2	0	0	0.431	0.942	1.000
78	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), HSD3B7(2), PON1(3), PON3(1), RDH11(1), RDH12(1), RDH13(1)	1289361	19	16	19	6	14	3	0	1	1	0	0.0641	0.942	1.000
79	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(12), GNAS(5), PRKACA(2), PRKAR1A(1)	924777	20	12	20	6	11	2	3	1	3	0	0.122	0.943	1.000
80	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(4), GGT1(2), SHMT1(1)	580887	7	7	7	4	4	1	0	1	1	0	0.569	0.945	1.000
81	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IFNG(1)	423529	1	1	1	1	0	0	0	0	1	0	0.847	0.946	1.000
82	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(5), CAPN1(2), CDK5(1), CSNK1A1(1), GSK3B(1), MAPT(1)	1283206	11	11	11	2	10	1	0	0	0	0	0.0605	0.952	1.000
83	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(1), ALPP(2), ALPPL2(1), SPR(1)	904413	9	8	8	4	6	1	1	1	0	0	0.396	0.954	1.000
84	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(3), CHKA(1), PCYT1A(1), PDHA1(1), PDHA2(6), PEMT(1)	972350	13	12	13	5	9	1	0	1	2	0	0.237	0.955	1.000
85	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(6), PRKCA(2), PTK2B(4)	962868	12	10	12	3	7	1	1	2	1	0	0.139	0.955	1.000
86	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CASP8(4), CFL1(1), PDE6D(1)	556827	7	6	7	3	3	0	1	3	0	0	0.676	0.957	1.000
87	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), COASY(1), DPYD(17), DPYS(12), ENPP1(4), ENPP3(4), ILVBL(1), PANK2(1), PANK3(1), PANK4(3), UPB1(2), VNN1(4)	2462862	54	31	52	12	36	3	2	9	4	0	0.00579	0.958	1.000
88	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO2(1), ENO3(1), FARS2(1), GOT1(3), GOT2(1), PAH(3), TAT(4)	1193388	15	13	15	4	11	1	1	2	0	0	0.0897	0.961	1.000
89	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(1), GH1(2), GHR(8), IGF1(5), IGF1R(4), PIK3CA(3), PIK3R1(3)	1889508	29	23	28	9	21	1	0	4	2	1	0.124	0.962	1.000
90	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(3), BIRC3(3), CASP8(4)	1166737	10	10	10	3	5	0	2	3	0	0	0.357	0.963	1.000
91	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(1), COQ7(1), NDUFA12(1), NDUFA13(1)	568287	4	4	4	2	3	1	0	0	0	0	0.726	0.965	1.000
92	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFB2(1), NDUFB5(1), NDUFB6(1), NDUFV1(2)	998428	5	5	5	0	3	0	1	1	0	0	0.160	0.968	1.000
93	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(5), GABRA2(8), GABRA3(7), GABRA4(4), GABRA6(8), GPX1(1), PRKCE(2)	1107230	35	27	31	13	28	0	1	3	2	1	0.0925	0.974	1.000
94	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(6), GNA12(1), PRKACB(3), PRKACG(3), PRKAG1(1), PRKAR2A(1), PRKAR2B(1)	1438973	16	13	16	4	9	1	0	4	2	0	0.227	0.975	1.000
95	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(3), HLA-DRA(3), HLA-DRB1(1), IFNG(1), IFNGR1(1), IFNGR2(2), IL12RB1(3), IL18R1(4), IL2RA(1), IL4R(6)	1803579	25	18	25	8	15	0	0	5	5	0	0.222	0.976	1.000
96	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ARPC2(1), ARPC4(1), CDC42(2), WASF1(2), WASL(1)	1101552	7	6	7	2	2	1	0	1	3	0	0.450	0.978	1.000
97	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2A(1), ADORA3(3), P2RY1(1), P2RY6(1)	848027	7	7	7	4	4	2	0	1	0	0	0.376	0.980	1.000
98	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL2(1), ST6GALNAC2(1), ST8SIA1(1)	808097	5	5	5	1	5	0	0	0	0	0	0.173	0.980	1.000
99	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), IFNAR2(5), IFNB1(2), JAK1(2), STAT2(4), TYK2(1)	1537590	16	12	16	4	5	1	1	5	4	0	0.228	0.983	1.000
100	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(5), ACOX3(3), FADS2(2), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2)	1442314	21	19	21	8	15	2	0	2	2	0	0.172	0.983	1.000
101	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), IL4R(6), JAK1(2), JAK2(2), TYK2(1)	1491565	14	14	14	4	9	0	0	3	2	0	0.316	0.983	1.000
102	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), IL4R(6), JAK1(2), JAK2(2), TYK2(1)	1491565	14	14	14	4	9	0	0	3	2	0	0.316	0.983	1.000
103	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	IFNG(1), IL2RA(1), TGFB3(2), TGFBR2(2), TGFBR3(1), TOB2(1)	1504114	8	8	8	1	5	0	0	1	2	0	0.102	0.985	1.000
104	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(1), PPARG(4), RETN(1)	832917	8	7	8	3	6	0	0	2	0	0	0.438	0.986	1.000
105	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(3), EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G2(1), EIF4G3(4), GHR(8), IRS1(1), MAPK1(1), MAPK14(2), MKNK1(2), PABPC1(2), PDK2(2), PDPK1(1), PIK3CA(3), PIK3R1(3), PRKCA(2)	3914439	40	31	39	8	23	3	1	6	6	1	0.0206	0.987	1.000
106	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(4), CKM(1), GPT(1), LDHA(1), LDHB(2), LDHC(2), MAPK14(2), NCL(3)	1279681	16	14	16	6	9	1	2	2	2	0	0.332	0.990	1.000
107	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK14(2), NFKB1(1), RELA(2), TNFRSF13B(1), TNFRSF17(1), TRAF3(2), TRAF5(2), TRAF6(1)	2046586	13	13	13	4	5	3	0	4	1	0	0.359	0.990	1.000
108	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), DRD1(1), DRD2(7), GRM1(4), PLCB1(16), PPP3CA(4), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	2273760	43	27	42	11	30	1	2	5	5	0	0.00572	0.991	1.000
109	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(4), GZMB(1), ITGAL(6), ITGB2(2)	1236394	13	12	13	6	6	2	0	2	3	0	0.462	0.991	1.000
110	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(1), B4GALT2(1), B4GALT3(1), FUT8(2), ST3GAL2(1), ST3GAL3(1)	1118931	9	8	9	3	6	1	1	0	1	0	0.328	0.992	1.000
111	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(3), CDC42(2), CHUK(1), ELK1(1), H2AFX(2), MAP2K1(3), NFKB1(1), PIK3CA(3), PIK3R1(3), RAF1(3), RALA(1), RALGDS(2), RELA(2), RHOA(1)	2627321	28	22	26	9	13	4	1	7	2	1	0.219	0.992	1.000
112	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ITGA4(10), ITGAL(6), ITGAM(3), ITGB1(1), ITGB2(2), SELE(4), SELL(3), SELP(11)	2257263	42	30	40	11	32	2	1	5	2	0	0.0206	0.992	1.000
113	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), EIF2S1(1), NFKB1(1), NFKBIA(1), RELA(2)	1264420	6	6	6	2	1	2	1	2	0	0	0.573	0.992	1.000
114	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	CDKN1A(1), CFL1(1), E2F2(1), MDM2(2), PRB1(7)	909685	12	9	11	4	7	1	0	4	0	0	0.446	0.993	1.000
115	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(3), ARG1(1), ASL(2), CKM(1), CKMT2(2), CPS1(5), GAMT(1), GATM(2), ODC1(3), OTC(1), SMS(4)	2462958	25	21	25	7	11	3	2	5	4	0	0.0927	0.993	1.000
116	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), DUSP14(1), HBEGF(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(2), WDR1(1)	1515518	13	12	13	6	6	2	0	1	4	0	0.671	0.993	1.000
117	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(1), SULT1E1(2), SULT2A1(1)	871700	4	4	4	3	2	0	0	0	2	0	0.791	0.993	1.000
118	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(4), IL1B(2)	930249	6	6	5	2	5	0	0	0	1	0	0.308	0.994	1.000
119	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), CREBBP(4), DFFA(1), GZMA(4), GZMB(1)	1509478	11	9	11	3	5	0	1	4	1	0	0.405	0.994	1.000
120	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1)	647268	1	1	1	0	0	0	0	1	0	0	0.839	0.994	1.000
121	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ITGAL(6), ITGAM(3), ITGB2(2), SELE(4), SELL(3)	1466131	20	18	20	8	14	2	1	2	1	0	0.242	0.994	1.000
122	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	SDHB(1), UQCRC1(2)	949980	3	3	3	1	1	0	1	0	1	0	0.552	0.994	1.000
123	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(2), NFYC(1), RB1(2)	953539	5	3	5	2	0	0	0	4	0	1	0.819	0.994	1.000
124	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PRKCA(2)	707833	2	2	2	1	1	0	0	0	1	0	0.707	0.995	1.000
125	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), IDI1(1), SQLE(2)	455136	4	4	4	3	1	1	1	1	0	0	0.837	0.995	1.000
126	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(3), ANXA1(3), CALM2(1), GNAS(5), NFKB1(1), NOS3(6), NPPA(1), PIK3CA(3), PIK3R1(3), RELA(2), SYT1(8)	2539284	36	26	35	10	24	2	2	6	1	1	0.0761	0.996	1.000
127	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(5), HK1(2), HK2(4), HK3(3), IMPA1(1), PGM1(3)	1456061	18	13	18	6	14	0	1	2	1	0	0.133	0.996	1.000
128	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), GRB2(1), IGF1R(4), IRS1(1), MAP2K1(3), MAPK1(1), PIK3CA(3), PIK3R1(3), RAF1(3), SOS1(3)	2709660	25	22	23	8	14	2	1	4	3	1	0.249	0.996	1.000
129	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(9), C5(4), C6(21), C7(11), C8A(8), C9(4)	1785640	57	35	56	20	43	1	1	7	5	0	0.0833	0.996	1.000
130	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), GNAQ(1), ITPKB(1)	854169	3	3	3	0	1	0	1	0	1	0	0.427	0.996	1.000
131	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), UGDH(1), UXS1(2)	703590	4	4	4	3	3	0	0	0	1	0	0.793	0.996	1.000
132	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDPS(1), HMGCR(5), HMGCS1(1), IDI1(1), MVD(1), NSDHL(2), SC4MOL(2), SC5DL(1), SQLE(2)	1879299	18	15	18	6	3	5	2	5	3	0	0.373	0.996	1.000
133	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(6), CD4(5), ITGAL(6), ITGB2(2), PTPRC(16)	1591479	35	22	33	13	26	4	1	3	1	0	0.0632	0.997	1.000
134	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(2), AKT3(1), CDKN1A(1), ELK1(1), GRB2(1), MAP2K1(3), MAP2K2(2), NTRK1(5), PIK3CA(3), PIK3CD(3), SOS1(3)	2266442	28	21	26	9	13	3	0	9	3	0	0.277	0.997	1.000
135	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), GGPS1(1), IDI1(1), SQLE(2)	607803	5	5	5	3	2	1	1	1	0	0	0.739	0.997	1.000
136	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1R(3), C1S(3), C2(3), C3(9), C5(4), C6(21), C7(11), C8A(8), C9(4)	2479178	68	39	66	23	50	3	1	9	5	0	0.0362	0.997	1.000
137	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(1), ADSL(1), ADSS(2), AGXT(7), AGXT2(5), ASL(2), ASNS(3), CAD(4), DDO(3), GAD1(5), GAD2(4), GOT1(3), GOT2(1), GPT(1), NARS(1), PC(7)	3726030	53	39	52	14	33	6	4	7	3	0	0.00379	0.997	1.000
138	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(1), DFFA(1), GZMB(1), HMGB1(1), TOP2A(2), TOP2B(5)	1278316	11	9	11	3	8	0	0	2	1	0	0.416	0.997	1.000
139	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	ABO(3), B3GNT1(2), FUT1(1), ST8SIA1(1)	754482	7	7	7	4	6	0	1	0	0	0	0.483	0.997	1.000
140	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), GPI(1), HK1(2), PFKL(2), PGK1(3), PKLR(2)	1302002	13	9	13	3	6	3	0	3	1	0	0.0987	0.997	1.000
141	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(2), NEDD8(1), RB1(2)	1224951	6	6	6	7	0	0	1	3	1	1	0.991	0.997	1.000
142	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(1), IFNGR1(1), JAK1(2), JAK2(2), PTPRU(2), REG1A(2)	1628892	12	12	12	5	6	0	0	2	4	0	0.616	0.998	1.000
143	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(2), JAK2(2), JAK3(1), PIAS1(3), PIAS3(2), PTPRU(2), REG1A(2), SOAT1(3)	1948115	19	18	19	7	12	1	1	3	2	0	0.350	0.998	1.000
144	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), XYLT1(2), XYLT2(1)	903900	12	11	12	9	5	3	1	1	2	0	0.664	0.998	1.000
145	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), XYLT1(2), XYLT2(1)	903900	12	11	12	9	5	3	1	1	2	0	0.664	0.998	1.000
146	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL5(1), MAP2K3(4), MAPK14(2), NFATC1(5), NFATC2(2), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	1715392	24	16	24	9	15	2	0	3	4	0	0.203	0.998	1.000
147	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(5), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2)	1347468	18	16	18	8	12	0	1	1	4	0	0.568	0.998	1.000
148	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(7), CYP11A1(6), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(4), HSD11B1(2), HSD3B1(3), HSD3B2(3)	1399838	33	25	33	15	21	5	1	4	2	0	0.115	0.998	1.000
149	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(7), CYP11A1(6), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(4), HSD11B1(2), HSD3B1(3), HSD3B2(3)	1399838	33	25	33	15	21	5	1	4	2	0	0.115	0.998	1.000
150	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), ACO2(1), IDH1(3), IDH2(1), MDH2(1), SDHB(1)	1281300	10	6	8	2	7	0	0	2	1	0	0.170	0.998	1.000
151	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1R(3), C1S(3), C2(3), C3(9), C5(4), C6(21), C7(11), C8A(8), C8B(14), C9(4), MASP1(1)	2949646	83	42	80	27	60	4	3	11	5	0	0.0133	0.998	1.000
152	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), ACO2(1), CS(1), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1(3)	1826534	12	9	11	3	5	0	2	3	2	0	0.228	0.998	1.000
153	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	ABO(3), B3GNT1(2), B3GNT2(1), B3GNT3(3), B3GNT4(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), FUT1(1), FUT3(1), FUT5(3), FUT6(3), ST8SIA1(1)	2169869	23	18	23	8	17	0	1	1	4	0	0.0935	0.998	1.000
154	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	DPM2(1), ELK1(1), FOS(1), GRB2(1), JUN(1), KLK2(1), MAP2K1(3), PIK3CA(3), PIK3R1(3), PLCG1(6), RAF1(3), SOS1(3)	2707672	27	21	25	9	14	1	2	7	2	1	0.336	0.998	1.000
155	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(1), FYN(1), JUN(1), MAPK14(2), THBS1(8)	1056380	14	10	14	7	7	1	0	4	2	0	0.675	0.998	1.000
156	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), CASP8AP2(3), CES1(3)	1547502	7	6	7	2	3	1	0	2	1	0	0.576	0.999	1.000
157	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BET1L(1), GOSR1(1), SEC22B(1), SNAP25(2), SNAP29(1), STX10(1), STX11(1), STX12(1), STX17(1), STX19(1), STX3(1), STX5(4), STX6(1), TSNARE1(2), VAMP1(1), VAMP3(1), VAMP7(3)	2358932	25	18	25	7	11	3	1	4	6	0	0.127	0.999	1.000
158	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(4), GGT1(2), SHMT1(1)	766230	7	7	7	6	4	1	0	1	1	0	0.817	0.999	1.000
159	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(3), CHST12(1), CHST13(1), PAPSS1(1), SULT1A1(2), SULT1E1(2), SULT2A1(1), SULT2B1(3)	1296044	14	13	14	9	10	0	0	1	3	0	0.734	0.999	1.000
160	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(5), HK1(2), HK2(4), HK3(3), IMPA1(1), IMPA2(1), PGM1(3)	1656375	19	14	19	8	14	0	1	2	2	0	0.226	0.999	1.000
161	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ARPC2(1), ARPC4(1), CDC42(2), PAK1(2), PDGFRA(5), PIK3CA(3), PIK3R1(3), WASL(1)	1860559	18	14	18	7	9	1	1	3	3	1	0.539	0.999	1.000
162	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ITGA4(10), ITGAL(6), ITGB1(1), ITGB2(2), SELE(4), SELL(3)	1718349	28	23	28	10	20	2	1	4	1	0	0.230	0.999	1.000
163	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(3), EIF2S1(1), GSK3B(1), IGF1(5), IGF1R(4), INPPL1(5), PDK2(2), PDPK1(1), PIK3CA(3), PIK3R1(3)	2682557	28	23	28	9	16	3	1	5	2	1	0.176	0.999	1.000
164	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(12), F2(2), F2R(1), F2RL3(2), GNA12(1), GNAI1(1), GNAQ(1), PIK3CA(3), PIK3R1(3), PLCB1(16), PPP1R12B(4), PRKCA(2), PTK2B(4), ROCK1(2)	3682219	54	32	54	14	30	3	3	10	7	1	0.0168	0.999	1.000
165	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(1), IL4R(6), IRS1(1), JAK1(2), JAK3(1), STAT6(1)	2096972	15	15	15	4	9	1	0	3	2	0	0.211	0.999	1.000
166	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(3), PSMA6(2), PSMB1(1), PSMB2(1), PSMB6(1), PSMB8(2)	1258738	10	8	10	4	5	1	0	2	2	0	0.651	0.999	1.000
167	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(2), JAK1(2), PTPRU(2), REG1A(2), STAT2(4), TYK2(1)	1785969	14	12	14	7	3	1	1	4	5	0	0.705	0.999	1.000
168	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(1), IDH2(1), OGDH(4)	1351998	7	5	7	4	2	0	1	3	1	0	0.822	0.999	1.000
169	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(2), FBXW7(4), RB1(2)	1164333	10	8	10	8	4	0	1	4	0	1	0.961	0.999	1.000
170	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), HEMK1(2), LCMT1(2), METTL2B(2), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), WBSCR22(1)	2148701	21	19	21	8	10	4	2	3	2	0	0.217	0.999	1.000
171	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(8), CCNE1(1), CDC34(1), CUL1(2), RB1(2)	1213369	14	11	14	8	7	0	1	5	0	1	0.803	1.000	1.000
172	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(2), FDPS(1), GGCX(1), GGPS1(1), HMGCR(5), IDI1(1), MVD(1), NQO1(1), NSDHL(2), SC4MOL(2), SC5DL(1), SQLE(2), TM7SF2(1)	2746289	21	15	21	6	4	5	3	5	4	0	0.182	1.000	1.000
173	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IFNG(1), IL10(1), IL15(1), IL16(2), IL1A(1), IL3(2), IL5(1)	1410276	12	12	12	7	8	0	1	0	3	0	0.455	1.000	1.000
174	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(9), EIF2AK4(5), EIF2S1(1), GSK3B(1)	1660445	16	12	15	7	6	0	1	6	3	0	0.840	1.000	1.000
175	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(8), AGT(3), AGTR1(2), AGTR2(4), BDKRB2(2), KNG1(2), NOS3(6), REN(3)	1410179	30	23	30	13	23	1	3	2	1	0	0.110	1.000	1.000
176	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(1), HMGCR(5), IDI1(1), MVD(1), NQO1(1), SC5DL(1), SQLE(2)	1570014	14	11	14	6	2	3	2	5	2	0	0.617	1.000	1.000
177	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1A(1), BMPR2(2)	897977	5	5	5	3	2	1	0	1	1	0	0.754	1.000	1.000
178	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	HMOX1(1), IL10(1), IL10RA(2), IL10RB(1), IL1A(1), JAK1(2), STAT3(6), STAT5A(1)	1738260	15	12	15	6	5	3	3	3	1	0	0.377	1.000	1.000
179	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), GOT1(3), GOT2(1), GPT(1), MDH2(1), ME1(8), ME2(1), ME3(4), PGK1(3), PKLR(2), PKM2(1), TKT(4)	2576532	35	22	34	10	22	4	2	4	3	0	0.0185	1.000	1.000
180	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), ACO2(1), AFMID(1), CS(1), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1(3)	1912547	13	10	12	4	5	0	3	3	2	0	0.294	1.000	1.000
181	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDKN1A(1), CHEK1(1), NEK1(3)	990781	6	5	6	3	3	0	0	2	1	0	0.823	1.000	1.000
182	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1R(3), C1S(3), C2(3), C3(9), C5(4), C6(21), C7(11), C8A(8), C9(4), MASP1(1), MBL2(5)	3020632	74	41	72	26	55	3	1	10	5	0	0.0358	1.000	1.000
183	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(6), MDM2(2), PIK3CA(3), PIK3R1(3), POLR1A(2), POLR1B(1), RB1(2), TBX2(1), TWIST1(1)	2620083	21	17	21	9	9	3	1	5	1	2	0.527	1.000	1.000
184	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCR(2), CRKL(1), FOS(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(3), MAP2K4(1), MAP3K1(1), PIK3CA(3), PIK3R1(3), RAF1(3), SOS1(3), STAT5A(1), STAT5B(1)	3982484	30	22	28	9	15	0	4	5	5	1	0.195	1.000	1.000
185	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), ABCC2(2), BCHE(3), CES1(3), CES2(2), CYP3A4(8), CYP3A5(5), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4)	3270368	44	27	44	13	29	3	2	3	7	0	0.00723	1.000	1.000
186	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CSK(1), GRB2(1), PRKCA(2), PTPRA(2)	1324426	7	6	7	9	3	0	0	2	2	0	0.995	1.000	1.000
187	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(5), ACOX3(3), ELOVL6(1), FADS2(2), FASN(5), HADHA(4), HSD17B12(1), SCD(1)	2024716	22	17	22	7	13	2	0	6	1	0	0.120	1.000	1.000
188	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(8), CCND2(1), CCND3(1), CCNE1(1), CDC25A(1), CDK6(1), CDKN1A(1), RB1(2), RBL1(5)	2125272	21	14	21	9	12	1	1	5	1	1	0.459	1.000	1.000
189	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(1), ALAS2(3)	1078831	5	5	5	5	3	0	0	1	1	0	0.943	1.000	1.000
190	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(3), ANXA2(1), ANXA6(2), CYP11A1(6), EDN1(3), EDNRA(4), EDNRB(3), HSD11B1(2), PLA2G4A(4), PTGDR(3), PTGER2(2), PTGFR(1), PTGIR(1), PTGIS(2), PTGS1(7), PTGS2(2), S100A6(1), SCGB1A1(1), TBXAS1(3)	2917783	51	36	50	19	32	5	0	7	7	0	0.0291	1.000	1.000
191	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(3), BCAR1(1), GRB2(1), ITGB1(1), MAPK1(1), PDK2(2), PDPK1(1), PIK3CA(3), PIK3R1(3), PTK2(2), SOS1(3)	2617224	21	19	21	8	10	1	0	6	3	1	0.553	1.000	1.000
192	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(3), B3GALT1(1), B3GALT2(1), FUT1(1), FUT3(1), ST3GAL3(1)	1020444	8	7	8	4	7	1	0	0	0	0	0.402	1.000	1.000
193	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(2), CSF1(4), FCGR3A(1), IL1B(2), IL6R(1), SELL(3), SPN(2), TNFRSF8(7), TNFSF8(1)	1841742	31	22	29	11	22	1	2	3	3	0	0.106	1.000	1.000
194	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(6), CYP11B2(2), CYP17A1(2), HSD11B1(2), HSD3B1(3), HSD3B2(3)	985316	23	20	23	13	14	4	1	3	1	0	0.254	1.000	1.000
195	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD4(5), CREBBP(4), CSK(1), GNAS(5), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTPRC(16)	3226876	58	32	57	18	33	5	4	10	6	0	0.0342	1.000	1.000
196	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD4(5), CREBBP(4), CSK(1), GNAS(5), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTPRC(16)	3226876	58	32	57	18	33	5	4	10	6	0	0.0342	1.000	1.000
197	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), GOT1(3), GOT2(1), GPT(1), MDH2(1), ME1(8), ME3(4), PGK1(3), PGK2(10), PKLR(2), PKM2(1), TKT(4), TKTL2(8)	2883814	52	30	48	17	34	7	2	6	3	0	0.00970	1.000	1.000
198	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	12	A4GALT(1), FUT1(1), GBGT1(1), HEXB(1), NAGA(1), ST3GAL2(1), ST8SIA1(1)	1342150	7	6	7	7	5	0	0	0	2	0	0.894	1.000	1.000
199	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(1), CBS(1), CTH(1), DNMT1(6), DNMT3A(1), MARS(2), MARS2(1), MAT1A(2), MAT2B(2), MTR(4)	2514289	23	19	23	8	14	0	2	4	3	0	0.214	1.000	1.000
200	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLRMT(1)	1905828	14	13	14	6	8	1	1	3	1	0	0.445	1.000	1.000
201	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(6), CD8A(1), ITGAL(6), ITGB2(2), PTPRC(16)	1518536	31	22	29	13	24	3	1	2	1	0	0.130	1.000	1.000
202	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(2), JAK3(1), MAPK1(1), STAT3(6), TYK2(1)	1656662	13	11	13	9	5	2	0	3	3	0	0.876	1.000	1.000
203	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1)	1134542	7	6	7	6	3	2	0	1	1	0	0.837	1.000	1.000
204	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1)	1134542	7	6	7	6	3	2	0	1	1	0	0.837	1.000	1.000
205	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(3), CASP10(1), CASP3(1), CASP8(4), DFFA(1), GZMB(1), SCAP(5), SREBF1(1), SREBF2(1)	2586158	19	17	19	5	13	0	1	4	1	0	0.150	1.000	1.000
206	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(2), F2R(1), F5(9), F7(1), FGA(8), FGB(5), FGG(3), PROC(2), PROS1(7), SERPINC1(2), TFPI(1)	2345111	44	28	44	15	29	5	3	6	1	0	0.132	1.000	1.000
207	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	13	A4GALT(1), B3GALNT1(3), FUT1(1), GBGT1(1), HEXB(1), NAGA(1), ST3GAL2(1), ST8SIA1(1)	1431582	10	9	10	7	6	0	2	0	2	0	0.761	1.000	1.000
208	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), CBS(1), CTH(1), GGT1(2), MARS(2), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(1), SCLY(1), SEPHS1(1)	1780424	16	15	16	8	9	1	1	2	3	0	0.517	1.000	1.000
209	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(3), B3GAT2(2), B3GAT3(3), CHPF(2), CHST11(3), CHST12(1), CHST13(1), CHST14(1), CHSY1(2), DSE(5), XYLT1(2), XYLT2(1)	1883890	26	19	26	10	15	5	0	5	1	0	0.115	1.000	1.000
210	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(3), AKT2(2), AKT3(1), GRB2(1), MAPK1(1), PIK3CA(3), PIK3CD(3), PTK2B(4), RBL2(2), SOS1(3)	2812649	23	17	23	6	11	1	0	9	2	0	0.249	1.000	1.000
211	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(3), EXTL1(1), EXTL3(3), GLCE(4), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(2), HS6ST3(4), NDST1(1), NDST2(1), NDST3(7), NDST4(15)	2896676	48	33	48	17	27	5	2	6	8	0	0.0549	1.000	1.000
212	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKCA(2), SYT1(8)	2953506	39	25	38	10	25	2	2	7	3	0	0.0627	1.000	1.000
213	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), UGDH(1)	1205706	8	8	8	8	4	1	1	1	1	0	0.898	1.000	1.000
214	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(1), ATM(6), CCNE1(1), CDKN1A(1), MDM2(2), PCNA(2), RB1(2), TIMP3(2)	2367716	17	14	17	8	4	2	1	7	2	1	0.775	1.000	1.000
215	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ARPC2(1), ARPC4(1), NCKAP1(2), NTRK1(5), PIR(1), WASF1(2), WASF2(3), WASF3(4), WASL(1)	2122304	20	18	20	8	11	3	0	2	4	0	0.487	1.000	1.000
216	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), HBXIP(1), PTK2B(4), SOS1(3)	1255272	9	9	9	5	6	0	0	2	1	0	0.784	1.000	1.000
217	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	CREB5(2), MAPK1(1), RAF1(3), SNX13(1)	1386994	7	6	7	6	4	0	1	1	1	0	0.897	1.000	1.000
218	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLE(4), POLG(4), POLL(1), POLQ(7)	2381495	18	18	18	8	11	0	1	3	3	0	0.534	1.000	1.000
219	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(4), ITGB1(1), KLRC1(2), KLRC3(4), KLRC4(2), KLRD1(1), LAT(1), MAP2K1(3), PAK1(2), PIK3CA(3), PIK3R1(3), PTK2B(4), PTPN6(2), SYK(5), VAV1(5)	2583767	42	29	40	15	28	1	0	7	5	1	0.162	1.000	1.000
220	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(3), PSMA6(2), PSMB1(1), PSMB2(1), PSMB6(1), PSMC3(3)	1856987	11	8	11	4	5	2	0	2	2	0	0.611	1.000	1.000
221	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(3), ACO2(1), ACSS1(1), ACSS2(1), IDH1(3), IDH2(1), MDH2(1)	1908138	13	8	11	3	8	0	0	4	1	0	0.159	1.000	1.000
222	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(1), MNAT1(2), SHH(2), XPO1(2)	1245649	7	7	7	5	3	0	1	2	1	0	0.917	1.000	1.000
223	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), FOS(1), GNAQ(1), JUN(1), MAPK14(2), PLCG1(6), PRKCA(2), PTK2B(4), SYT1(8)	1970103	26	19	25	10	14	2	2	5	3	0	0.228	1.000	1.000
224	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(1), PER1(2)	1207014	7	7	7	5	5	1	0	0	1	0	0.821	1.000	1.000
225	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(7), PGAP1(2), PIGA(2), PIGB(1), PIGC(1), PIGG(2), PIGK(1), PIGM(2), PIGN(2), PIGO(6), PIGQ(4), PIGU(1), PIGV(3), PIGW(2), PIGX(1), PIGZ(1)	3408110	38	26	38	11	14	4	6	13	1	0	0.109	1.000	1.000
226	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(6), CDC25A(1), CHEK1(1), MYT1(7)	1972060	15	15	15	9	9	2	0	2	2	0	0.801	1.000	1.000
227	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), IARS(2), IARS2(1), ILVBL(1), LARS(3), PDHA1(1), PDHA2(6), VARS(4), VARS2(3)	2691412	25	19	25	8	18	1	1	3	2	0	0.137	1.000	1.000
228	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(6), MAP2(5), PRKACB(3), PRKACG(3), PRKAG1(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2)	2590778	22	16	22	7	11	2	1	3	5	0	0.333	1.000	1.000
229	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(2), POLD1(2), POLG(4), PRPS2(1), RRM1(1)	1768088	11	10	11	7	5	0	1	2	3	0	0.880	1.000	1.000
230	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(12), AKT1(3), GNAI1(1), ITGAV(2), ITGB3(3), MAPK1(1), PDGFA(1), PDGFRA(5), PIK3CA(3), PIK3R1(3), PLCB1(16), PRKCA(2), PTK2(2), SMPD1(2), SPHK1(1)	3861921	57	35	57	19	32	3	6	8	7	1	0.0542	1.000	1.000
231	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), CASP3(1), DAXX(1), FAS(1), FASLG(4), HSPB1(1), HSPB2(1), IL1A(1), MAPKAPK2(2)	1621160	13	11	13	7	6	0	0	5	2	0	0.698	1.000	1.000
232	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(7), ABAT(1), ACAT2(1), ACSM1(9), AKR1B10(3), ALDH1B1(2), ALDH3A1(1), ALDH5A1(1), ALDH7A1(3), ALDH9A1(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(5), GAD2(4), HADHA(4), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(4), HSD3B7(2), ILVBL(1), L2HGDH(1), OXCT1(2), OXCT2(1), PDHA1(1), PDHA2(6), PLA1A(3), PRDX6(1), RDH11(1), RDH12(1), RDH13(1)	5787208	83	44	82	23	51	10	5	10	7	0	0.000858	1.000	1.000
233	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(2), BTK(5), CALM2(1), CD79A(1), ELK1(1), FOS(1), GRB2(1), JUN(1), LYN(2), MAP2K1(3), MAP3K1(1), MAPK14(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKCA(2), RAF1(3), SOS1(3), SYK(5), SYT1(8), VAV1(5)	5378633	73	41	70	19	46	2	3	15	7	0	0.0129	1.000	1.000
234	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(4), ERBB3(2), NRG1(4), UBE2D1(1)	1477553	14	13	14	9	8	1	1	3	1	0	0.879	1.000	1.000
235	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(1), EPO(2), HIF1A(3), JAK2(2), NFKB1(1), NFKBIA(1), RELA(2)	1786744	14	11	14	9	3	1	2	6	2	0	0.935	1.000	1.000
236	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(6), AXIN1(3), CD14(1), CTNNB1(6), FZD1(2), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(3), LBP(2), LEF1(1), LY96(3), NFKB1(1), PDPK1(1), PIK3CA(3), PIK3R1(3), RELA(2), TIRAP(1), TLR4(6), TOLLIP(1), WNT1(1)	4338374	52	37	52	17	28	3	2	9	9	1	0.120	1.000	1.000
237	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(6), ACACB(3), FASN(5), OLAH(1)	2239690	15	14	15	5	9	1	0	4	1	0	0.244	1.000	1.000
238	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(3), EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G2(1), EIF4G3(4), MKNK1(2), PDK2(2), PDPK1(1), PIK3CA(3), PIK3R1(3), TSC1(1), TSC2(3)	3824275	28	24	28	9	14	2	1	7	3	1	0.316	1.000	1.000
239	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), HEMK1(2), LCMT1(2), METTL2B(2), METTL6(1), PCYT1A(1), PCYT1B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), WBSCR22(1)	2002224	16	14	16	8	6	2	2	4	2	0	0.579	1.000	1.000
240	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), BAIAP2(3), CASP3(1), CASP8(4), INSR(6), ITCH(1), MAGI1(11), MAGI2(4), RERE(8), WWP1(1), WWP2(1)	3436113	43	31	43	14	27	2	1	9	4	0	0.192	1.000	1.000
241	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(12), AKT1(3), CSF2RB(6), IGF1(5), IGF1R(4), IL3(2), IL3RA(3), PIK3CA(3), PIK3R1(3), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	3120663	51	35	51	20	31	4	2	6	7	1	0.0916	1.000	1.000
242	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(2), DPEP1(1), GGT1(2), LTA4H(2), PLA2G6(2), PTGIS(2), PTGS1(7), PTGS2(2), TBXAS1(3)	2119116	25	16	25	11	16	2	1	3	3	0	0.145	1.000	1.000
243	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(2), UBE2D1(1), UBE2I(1), UBE2J1(2), UBE2L6(1), UBE2S(1)	1510762	9	7	9	6	4	1	1	2	1	0	0.885	1.000	1.000
244	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(1), CDO1(2), CTH(1), GOT1(3), GOT2(1), LDHA(1), LDHAL6A(4), LDHAL6B(1), LDHB(2), LDHC(2), SULT1B1(4), SULT1C4(3), SULT4A1(1)	1790407	30	20	29	11	19	1	3	5	2	0	0.207	1.000	1.000
245	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), GNA12(1), GNAQ(1), MYL2(1), MYLK(9), PLCB1(16), PPP1R12B(4), PRKCA(2), ROCK1(2)	2962098	39	25	39	12	25	0	2	7	5	0	0.113	1.000	1.000
246	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(4), G6PD(1), GCLC(1), GGT1(2), GPX1(1), GPX5(2), GSS(2), GSTA1(2), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(3), IDH2(1), MGST1(1), MGST2(1), MGST3(1), PGD(2)	2566707	27	20	26	10	17	2	2	5	1	0	0.113	1.000	1.000
247	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), AKR1D1(7), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), BAAT(2), CEL(5), CYP27A1(2), CYP7A1(1), SOAT2(1), SRD5A1(1), SRD5A2(3)	3333566	56	31	54	22	39	7	2	6	2	0	0.0809	1.000	1.000
248	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(2), AKT3(1), GRB2(1), GSK3B(1), IL4R(6), IRS1(1), JAK1(2), JAK3(1), MAP4K1(3), MAPK1(1), PIK3CA(3), PIK3CD(3), PIK3R1(3), PPP1R13B(3), RAF1(3), SOS1(3), SOS2(4), STAT6(1)	5189103	45	28	45	10	23	2	3	11	5	1	0.0245	1.000	1.000
249	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR2(2), CCR3(5), CCR4(4), CCR7(1), CD4(5), CXCR3(1), IFNG(1), IFNGR1(1), IFNGR2(2), IL12RB1(3), IL18R1(4), IL4R(6), IL5(1), TGFB3(2)	2842536	38	26	38	15	23	1	0	7	7	0	0.0985	1.000	1.000
250	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(1), IFNG(1), IKBKB(3), JUN(1), MAP3K1(1), MAP3K5(5), MAP4K5(2), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(2)	2740297	22	19	22	9	8	3	1	6	4	0	0.472	1.000	1.000
251	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ESR1(2), GREB1(4), HSPB1(1), HSPB2(1), MTA1(1), PDZK1(1)	1517285	10	9	10	6	6	0	1	3	0	0	0.721	1.000	1.000
252	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(14), COL4A2(8), COL4A3(13), COL4A4(22), COL4A5(20), COL4A6(6), P4HB(1), SLC23A2(2), SLC2A1(3), SLC2A3(3)	3556299	92	50	90	20	72	4	3	6	7	0	0.0785	1.000	1.000
253	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(4)	1728275	14	13	14	9	6	4	0	3	1	0	0.723	1.000	1.000
254	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(5), CFL1(1), GNAQ(1), GNAS(5), MAP2K1(3), MAPK1(1), MYL2(1), NOX1(3), PIK3C2G(10), PLCB1(16), PPP1R12B(4), PRKCA(2), PTK2(2), RAF1(3), ROCK2(6)	3574910	64	41	62	21	41	1	4	13	5	0	0.0941	1.000	1.000
255	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), ABAT(1), ACY3(1), ADSL(1), ADSS(2), ADSSL1(5), AGXT(7), AGXT2(5), ASL(2), ASNS(3), ASS1(2), CAD(4), DARS2(2), DDO(3), DLAT(1), GAD1(5), GAD2(4), GOT1(3), GOT2(1), GPT(1), NARS(1), NARS2(1), PC(7), PDHA1(1), PDHA2(6)	5398849	72	46	71	23	45	8	4	11	4	0	0.00922	1.000	1.000
256	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	ELK1(1), FOS(1), GRB2(1), INSR(6), IRS1(1), JUN(1), MAP2K1(3), PIK3CA(3), PIK3R1(3), PTPN11(2), RAF1(3), RASA1(1), SLC2A4(3), SOS1(3)	3653547	32	22	30	10	12	1	2	12	4	1	0.360	1.000	1.000
257	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(1), F2RL3(2), GNAI1(1), ITGA1(3), ITGB1(1), MAP2K1(3), MAPK1(1), PLA2G4A(4), PLCB1(16), PRKCA(2), PTGS1(7), PTK2(2), RAF1(3), SYK(5), TBXAS1(3)	3467261	56	33	54	20	36	3	3	7	7	0	0.0751	1.000	1.000
258	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(3), AP2M1(2), BTK(5), EEA1(1), GSK3B(1), LYN(2), PDPK1(1), PFKL(2), PFKM(1), PLCG1(6), PRKCE(2), RAB5A(1)	3449919	27	19	27	9	13	3	2	6	3	0	0.132	1.000	1.000
259	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(6), FOS(1), GRB2(1), IL3(2), IL3RA(3), JAK2(2), MAP2K1(3), PTPN6(2), RAF1(3), SOS1(3), STAT5A(1), STAT5B(1)	2498003	28	22	26	12	18	1	2	3	4	0	0.384	1.000	1.000
260	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), CHRNG(1), MUSK(11), PIK3CA(3), PIK3R1(3), PTK2(2), PTK2B(4), RAPSN(1), TERT(1)	2314275	29	23	29	12	16	2	0	8	2	1	0.284	1.000	1.000
261	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(3), PSMA6(2), PSMB1(1), PSMB2(1), PSMB6(1), PSMC2(2), PSMC3(3), PSMD1(2)	2301872	15	11	15	8	8	2	0	3	2	0	0.830	1.000	1.000
262	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(3), AKT2(2), AKT3(1), BTK(5), DAPP1(1), GRB2(1), GSK3B(1), IARS(2), IGFBP1(1), INPP5D(6), PIK3CA(3), PPP1R13B(3), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SOS1(3), SOS2(4), TEC(4), YWHAB(1), YWHAQ(1)	4933750	50	33	49	13	30	1	4	11	4	0	0.0534	1.000	1.000
263	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BIK(1), BIRC3(3), CASP3(1), CASP8(4), DFFA(1)	1924487	11	11	11	5	6	0	1	4	0	0	0.687	1.000	1.000
264	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(4), EPRS(5), FARS2(1), GARS(2), HARS(2), IARS(2), LARS(3), MARS(2), MARS2(1), NARS(1), QARS(1), RARS(1), SARS(6), TARS(1), WARS(1), WARS2(2)	4599355	38	21	38	9	20	5	3	8	2	0	0.0392	1.000	1.000
265	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), BHMT(1), CBS(1), CTH(1), DNMT1(6), DNMT3A(1), MARS(2), MARS2(1), MAT1A(2), MAT2B(2), MTR(4), TAT(4)	2987138	27	21	27	10	16	1	2	5	3	0	0.269	1.000	1.000
266	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(5), CALM2(1), ELK1(1), FCER1A(4), FOS(1), GRB2(1), JUN(1), LYN(2), MAP2K1(3), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAPK1(1), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), PAK2(5), PIK3CA(3), PIK3R1(3), PLA2G4A(4), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), RAF1(3), SOS1(3), SYK(5), SYT1(8), VAV1(5)	6110357	88	44	85	24	52	3	6	20	6	1	0.0150	1.000	1.000
267	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(4), CD2(6), CD33(5), IFNA1(1), IFNB1(2), IFNG(1), IL10(1), IL3(2), IL5(1), ITGAX(6), TLR2(2), TLR4(6), TLR7(8), TLR9(3)	2646055	48	34	47	24	31	4	3	5	5	0	0.112	1.000	1.000
268	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), AKR1B10(3), AKR1D1(7), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), BAAT(2), CEL(5), CYP27A1(2), CYP7A1(1), HSD3B7(2), RDH11(1), RDH12(1), RDH13(1), SLC27A5(2), SOAT1(3), SOAT2(1), SRD5A1(1), SRD5A2(3)	4532861	70	36	67	28	46	10	4	7	3	0	0.0577	1.000	1.000
269	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC3(3), CASP10(1), CASP3(1), CASP8(4), DFFA(1), GZMB(1), LMNA(4), LMNB1(1), LMNB2(2)	2795111	19	15	19	8	8	3	1	7	0	0	0.560	1.000	1.000
270	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(1), ESR1(2), MAPK1(1), PELP1(1)	2089337	9	7	9	9	3	0	0	5	1	0	0.983	1.000	1.000
271	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(1), IFNB1(2), IKBKB(3), IL1A(1), IL1B(2), IL1R1(2), IL1RAP(1), IL1RN(1), IRAK1(3), IRAK2(2), IRAK3(2), JUN(1), MAP2K3(4), MAP2K6(1), MAP3K1(1), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(2), TGFB3(2), TOLLIP(1), TRAF6(1)	4201427	38	32	36	13	20	6	1	7	4	0	0.132	1.000	1.000
272	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(3), MPL(2), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), RAF1(3), RASA1(1), SOS1(3), STAT3(6), STAT5A(1), STAT5B(1), THPO(2)	4256918	41	27	39	13	20	3	4	8	5	1	0.239	1.000	1.000
273	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(1), DLAT(1), IDH2(1), IDH3G(1), MDH2(1), OGDH(4), PC(7), PDHA1(1), PDHA2(6), PDK2(2), PDK3(2), PDK4(1), PDP2(2), SDHB(1), SUCLG2(1)	4054263	33	22	33	11	16	2	3	6	6	0	0.176	1.000	1.000
274	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM2(1), ELK1(1), FOS(1), FYN(1), GRB2(1), JUN(1), LAT(1), LCK(1), MAP2K1(3), MAP2K4(1), MAP3K1(1), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB1(1), NFKBIA(1), PIK3CA(3), PIK3R1(3), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKCA(2), PTPN7(1), RAF1(3), RASA1(1), RELA(2), SOS1(3), SYT1(8), VAV1(5)	6736262	72	41	69	20	41	5	5	15	5	1	0.0300	1.000	1.000
275	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(1), EPO(2), FOS(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(3), PLCG1(6), PTPN6(2), RAF1(3), SOS1(3), STAT5A(1), STAT5B(1)	3030249	27	21	25	11	16	1	3	4	3	0	0.392	1.000	1.000
276	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(2), AKT3(1), BCR(2), BLNK(2), BTK(5), CD19(4), CSK(1), DAG1(1), EPHB2(8), GRB2(1), ITPKB(1), LYN(2), MAP2K1(3), MAP2K2(2), MAPK1(1), NFAT5(2), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PI3(1), PIK3CA(3), PIK3CD(3), PIK3R1(3), PLCG2(6), PPP1R13B(3), RAF1(3), SERPINA4(7), SOS1(3), SOS2(4), SYK(5), VAV1(5)	7509122	95	50	93	29	55	3	8	19	9	1	0.00858	1.000	1.000
277	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(3), AGTR2(4), EDN1(3), EDNRA(4), EDNRB(3), EGF(3), EGFR(4), FOS(1), JUN(1), NFKB1(1), PLCG1(6), PRKCA(2), RELA(2)	2928116	39	29	38	17	21	5	2	10	1	0	0.314	1.000	1.000
278	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(1), ACAT2(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(5), GAD2(4), HADHA(4), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(6), SDHB(1)	3694899	41	29	41	16	22	7	0	6	6	0	0.132	1.000	1.000
279	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(1), EGR2(2), GNAQ(1), MAP3K1(1), NFATC1(5), NFATC2(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RELA(2), SYT1(8), VIP(1)	3978681	50	28	49	17	29	4	4	9	4	0	0.127	1.000	1.000
280	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(1), ELK1(1), FOS(1), IKBKB(3), IRAK1(3), JUN(1), LY96(3), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAPK14(2), NFKB1(1), NFKBIA(1), PPARA(3), RELA(2), TIRAP(1), TLR10(2), TLR2(2), TLR3(4), TLR4(6), TLR6(4), TLR7(8), TLR9(3), TOLLIP(1), TRAF6(1)	5171019	62	39	62	23	33	9	4	13	3	0	0.117	1.000	1.000
281	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH5A1(1), CAD(4), CPS1(5), EPRS(5), GAD1(5), GAD2(4), GCLC(1), GFPT1(2), GLS(1), GLUL(2), GOT1(3), GOT2(1), GPT(1), GSS(2), QARS(1)	4738718	39	29	38	15	17	5	5	8	4	0	0.248	1.000	1.000
282	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(8), GRB2(1), INSR(6), IRS1(1), JAK2(2), MAP2K1(3), MAPK1(1), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), PTPN6(2), RAF1(3), RPS6KA1(1), SLC2A4(3), SOS1(3), STAT5A(1), STAT5B(1)	4722287	52	34	49	18	27	2	4	11	7	1	0.155	1.000	1.000
283	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(4), APOA4(1), CETP(4), CYP7A1(1), HMGCR(5), LDLR(3), LIPC(3), LPL(1), LRP1(7), SOAT1(3)	3941358	32	21	32	12	15	4	3	5	5	0	0.241	1.000	1.000
284	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	ELK1(1), FOS(1), GRB2(1), IL6R(1), IL6ST(5), JAK1(2), JAK2(2), JAK3(1), JUN(1), MAP2K1(3), PTPN11(2), RAF1(3), SOS1(3), STAT3(6)	3385692	32	17	30	12	14	2	1	11	4	0	0.522	1.000	1.000
285	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(3), CALM2(1), CAMK1(2), CAMK1G(1), IGF1(5), IGF1R(4), INSR(6), MAP2K6(1), MAPK14(2), MAPK7(1), MEF2A(1), MEF2D(1), NFATC1(5), NFATC2(2), PIK3CA(3), PIK3R1(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), SYT1(8)	4954177	60	35	59	21	36	3	2	14	4	1	0.0807	1.000	1.000
286	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(1), ATM(6), CASP3(1), EIF2S1(1), PRKCA(2), PTK2(2), PXN(1), TLN1(2)	3777305	19	18	19	8	9	2	0	5	3	0	0.535	1.000	1.000
287	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(2), AKT3(1), CISH(2), GRB2(1), IARS(2), IL13RA1(1), IL4R(6), INPP5D(6), JAK1(2), JAK2(2), JAK3(1), NR0B2(1), PI3(1), PIK3CA(3), PPP1R13B(3), SERPINA4(7), SOS1(3), SOS2(4), STAT6(1), TYK2(1)	5238902	53	35	53	17	36	0	2	9	6	0	0.105	1.000	1.000
288	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(1), LPL(1), NCOA1(3), NCOA2(2), PPARG(4)	2652551	15	15	15	7	9	0	0	5	1	0	0.721	1.000	1.000
289	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(12), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAQ(1), GNAS(5), JUN(1), MAP2K1(3), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), RAF1(3), RPS6KA3(1), SYT1(8)	4940183	76	38	73	26	45	4	6	12	9	0	0.0650	1.000	1.000
290	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2E1(1), GTF2F1(3), NCOA1(3), NCOA2(2), NCOA3(4), NCOR2(8), POLR2A(4), RARA(2), TBP(2)	3542462	30	22	30	11	24	0	3	3	0	0	0.204	1.000	1.000
291	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2M1(2), BIN1(1), CALM2(1), DNM1(1), EPN1(1), EPS15(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), SYNJ1(7), SYNJ2(2), SYT1(8)	3042177	36	25	35	14	21	4	1	9	1	0	0.311	1.000	1.000
292	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CDK5(1), CFL1(1), CHN1(1), MAP3K1(1), MYL2(1), MYLK(9), NCF2(2), PAK1(2), PDGFRA(5), PIK3CA(3), PIK3R1(3), PLD1(5), PPP1R12B(4), TRIO(6), VAV1(5), WASF1(2)	4940303	51	33	51	18	28	4	4	10	4	1	0.150	1.000	1.000
293	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), ALDOC(2), DLAT(1), ENO1(1), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GCK(5), GOT1(3), GOT2(1), GPI(1), HK1(2), HK2(4), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(2), MDH2(1), PC(7), PCK1(3), PDHA1(1), PDHA2(6), PFKL(2), PFKM(1), PGAM2(1), PGK1(3), PGK2(10), PKLR(2), PKM2(1), TNFAIP1(1)	6044285	74	46	73	27	49	5	4	11	5	0	0.00890	1.000	1.000
294	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(1), ASL(2), ASS1(2), CKM(1), CKMT2(2), CPS1(5), DAO(3), EPRS(5), GAMT(1), GATM(2), GOT1(3), GOT2(1), NOS1(17), NOS3(6), OTC(1), P4HA1(3), P4HA2(2), P4HA3(5), PRODH(1), RARS(1)	5107777	64	37	63	27	43	5	6	5	5	0	0.0818	1.000	1.000
295	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(4), CSF1R(4), DDX20(4), ETS1(1), ETS2(2), FOS(1), HDAC2(1), JUN(1), NCOR2(8), RBL1(5), RBL2(2), SIN3A(1)	3693313	34	25	34	15	22	0	1	7	4	0	0.367	1.000	1.000
296	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), ESRRA(1), MEF2A(1), MEF2D(1), PPARA(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), SLC2A4(3), SYT1(8)	2853761	38	27	37	17	23	4	2	5	4	0	0.278	1.000	1.000
297	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(1), ALDH5A1(1), CAD(4), CPS1(5), EPRS(5), GAD1(5), GAD2(4), GCLC(1), GFPT1(2), GFPT2(3), GLS(1), GLUL(2), GOT1(3), GOT2(1), GPT(1), GSS(2), QARS(1)	5632958	43	30	42	17	20	6	5	8	4	0	0.210	1.000	1.000
298	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(1), CALM2(1), CRKL(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP3K1(1), MAPK1(1), MAPK14(2), PAK1(2), PLCG1(6), PRKCA(2), PTK2B(4), RAF1(3), SOS1(3), SYT1(8)	3993602	48	32	45	19	25	4	4	9	6	0	0.325	1.000	1.000
299	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), ALDOC(2), DERA(2), FBP1(1), FBP2(1), G6PD(1), GPI(1), H6PD(2), PFKL(2), PFKM(1), PGD(2), PGLS(1), PGM1(3), PRPS1(2), PRPS1L1(2), PRPS2(1), RBKS(1), TKT(4), TKTL2(8)	3444568	39	26	37	19	21	7	3	3	5	0	0.216	1.000	1.000
300	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(1), FOS(1), GRB2(1), IL2RA(1), IL2RB(2), JAK1(2), JAK3(1), JUN(1), LCK(1), MAP2K1(3), RAF1(3), SOS1(3), STAT5A(1), STAT5B(1), SYK(5)	3268505	27	23	25	12	18	1	2	4	2	0	0.389	1.000	1.000
301	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(4), BCAR1(1), CSK(1), CTNNA2(3), CTNNB1(6), PTK2(2), PXN(1), VCL(2)	2685245	21	18	21	10	12	2	1	5	1	0	0.425	1.000	1.000
302	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(1), FOS(1), GRB2(1), JAK1(2), JUN(1), MAP2K1(3), MAP2K4(1), MAP3K1(1), PDGFA(1), PDGFRA(5), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), RAF1(3), RASA1(1), SOS1(3), STAT3(6), STAT5A(1)	4969423	45	30	43	15	22	4	5	9	4	1	0.228	1.000	1.000
303	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(1), ALG10B(3), ALG12(1), ALG13(3), ALG14(1), ALG2(2), ALG3(1), ALG5(1), ALG6(1), ALG8(4), ALG9(4), B4GALT1(1), B4GALT2(1), B4GALT3(1), DDOST(1), DPAGT1(1), FUT8(2), GANAB(2), MAN1A1(5), MAN1A2(1), MAN2A1(4), MGAT1(1), MGAT3(2), MGAT4A(3), MGAT4B(1), MGAT5B(5), RFT1(1), ST6GAL1(1), STT3B(2)	6034337	58	37	58	21	34	7	3	6	8	0	0.0714	1.000	1.000
304	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BIRC3(3), CASP3(1), CASP8(4), FAS(1), FASLG(4), GZMB(1), JUN(1), MAP2K4(1), MAP3K1(1), MAPK10(2), MCL1(2), MDM2(2), NFKB1(1), NFKBIA(1), PARP1(3), RELA(2), TNFSF10(3), TRAF1(1)	5184269	35	27	35	13	14	5	6	8	2	0	0.281	1.000	1.000
305	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CALM2(1), CAPN2(2), EP300(1), HDAC1(1), HDAC2(1), MEF2D(1), NFATC1(5), NFATC2(2), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKCA(2), SYT1(8)	3492531	35	22	34	13	23	1	3	5	3	0	0.294	1.000	1.000
306	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	A4GALT(1), ABO(3), B3GALNT1(3), B3GALT1(1), B3GALT2(1), B3GALT4(2), B3GNT1(2), B3GNT2(1), B3GNT3(3), B3GNT4(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), FUT1(1), FUT3(1), FUT5(3), FUT6(3), GBGT1(1), PIGA(2), PIGB(1), PIGC(1), PIGG(2), PIGK(1), PIGM(2), PIGN(2), PIGO(6), PIGQ(4), PIGU(1), PIGV(3), PIGX(1), PIGZ(1), ST3GAL2(1), ST3GAL3(1), ST6GALNAC5(3), ST8SIA1(1)	6781353	64	37	64	21	36	5	6	11	6	0	0.0224	1.000	1.000
307	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(3), AKT2(2), AKT3(1), BTK(5), FCER1A(4), FYN(1), GAB2(2), GRB2(1), IL3(2), IL5(1), INPP5D(6), LAT(1), LCP2(4), LYN(2), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(1), MS4A2(2), NRAS(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCG1(6), PLCG2(6), PRKCA(2), PRKCD(2), PRKCE(2), RAF1(3), SOS1(3), SOS2(4), SYK(5), VAV1(5), VAV3(1)	10195783	145	57	143	37	76	10	7	35	16	1	0.000126	1.000	1.000
308	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1D1(7), ARSB(1), ARSE(1), CYP11B1(4), CYP11B2(2), HSD11B1(2), HSD17B2(3), HSD3B1(3), HSD3B2(3), SRD5A1(1), SRD5A2(3), STS(1), SULT1E1(2), SULT2A1(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2B4(7)	3591942	58	37	57	27	39	7	3	4	5	0	0.159	1.000	1.000
309	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(5), ESR1(2), ESR2(3), ESRRA(1), HNF4A(3), NPM1(2), NR0B1(1), NR1D2(2), NR1H2(2), NR1H3(2), NR1I3(2), NR2F1(1), NR2F6(1), NR4A1(2), NR4A2(1), NR5A1(1), NR5A2(3), PGR(4), PPARA(3), PPARG(4), RARA(2), RARB(1), ROR1(2), RORA(2), RORC(2), RXRG(2), THRA(1), THRB(5), VDR(1)	5925608	63	36	62	25	42	5	2	7	7	0	0.0528	1.000	1.000
310	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTB(3), ACTG1(1), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(1), ARHGAP5(3), BCAR1(1), BIRC3(3), CAPN2(2), CCND2(1), CCND3(1), CDC42(2), COL11A1(17), COL11A2(8), COL1A1(15), COL1A2(13), COL2A1(9), COL3A1(20), COL4A1(14), COL4A2(8), COL4A4(22), COL4A6(6), COL5A1(10), COL5A2(12), COL5A3(16), COL6A1(1), COL6A2(6), COL6A3(16), COL6A6(13), COMP(4), CRKL(1), CTNNB1(6), DOCK1(2), EGF(3), EGFR(4), ELK1(1), ERBB2(1), FARP2(4), FIGF(2), FLNA(6), FLNB(8), FLNC(15), FLT1(8), FN1(9), FYN(1), GRB2(1), GRLF1(2), GSK3B(1), HGF(7), IBSP(4), IGF1(5), IGF1R(4), ITGA1(3), ITGA10(1), ITGA11(6), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGAV(2), ITGB1(1), ITGB3(3), ITGB4(5), ITGB6(1), ITGB7(1), ITGB8(4), JUN(1), KDR(8), LAMA1(7), LAMA2(12), LAMA3(16), LAMA4(3), LAMA5(5), LAMB1(1), LAMB2(1), LAMB3(2), LAMB4(9), LAMC1(6), LAMC2(4), LAMC3(2), MAP2K1(3), MAPK1(1), MAPK10(2), MAPK9(1), MET(8), MYL2(1), MYL5(1), MYL7(1), MYL9(1), MYLK(9), MYLK2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PARVB(1), PARVG(1), PDGFA(1), PDGFC(3), PDGFD(1), PDGFRA(5), PDGFRB(3), PDPK1(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PIP5K1C(2), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(2), PRKCG(5), PTK2(2), PXN(1), RAF1(3), RAPGEF1(3), RELN(16), RHOA(1), ROCK1(2), ROCK2(6), SHC2(2), SHC3(2), SOS1(3), SOS2(4), SPP1(1), THBS1(8), THBS2(5), THBS3(4), THBS4(2), TLN1(2), TLN2(11), TNC(7), TNN(12), TNR(15), TNXB(42), VASP(1), VAV1(5), VAV3(1), VCL(2), VEGFA(2), VEGFB(1), VEGFC(6), VTN(2), VWF(11), ZYX(2)	52396345	784	92	778	323	510	60	32	114	67	1	0.00213	1.000	1.000
311	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(3), ACTG1(1), COL11A1(17), COL11A2(8), COL17A1(8), COL1A1(15), COL1A2(13), COL2A1(9), COL3A1(20), COL4A1(14), COL4A2(8), COL4A4(22), COL4A6(6), COL5A1(10), COL5A2(12), COL5A3(16), COL6A1(1), COL6A2(6), COL6A3(16), COL6A6(13), COMP(4), DES(1), DSC1(9), DSC2(6), DSC3(7), DSG1(12), DSG2(8), DSG4(13), FN1(9), GJA1(1), GJA10(3), GJA5(2), GJA8(4), GJA9(1), GJB3(1), GJB4(4), GJB6(1), GJB7(1), GJD2(1), IBSP(4), INA(2), ITGA6(3), ITGB4(5), KRT1(5), KRT10(7), KRT12(5), KRT13(3), KRT14(1), KRT15(2), KRT16(1), KRT17(1), KRT2(4), KRT20(5), KRT23(3), KRT24(1), KRT25(4), KRT27(1), KRT28(4), KRT3(2), KRT31(3), KRT32(3), KRT33B(1), KRT34(7), KRT36(4), KRT37(2), KRT38(2), KRT39(3), KRT4(5), KRT40(2), KRT5(6), KRT6A(4), KRT6B(2), KRT6C(7), KRT7(1), KRT71(4), KRT72(4), KRT73(2), KRT74(3), KRT75(6), KRT76(3), KRT77(2), KRT78(2), KRT79(4), KRT8(1), KRT82(3), KRT83(1), KRT84(3), KRT85(2), KRT86(1), KRT9(6), LAMA1(7), LAMA2(12), LAMA3(16), LAMA4(3), LAMA5(5), LAMB1(1), LAMB2(1), LAMB3(2), LAMB4(9), LAMC1(6), LAMC2(4), LAMC3(2), LMNA(4), LMNB1(1), LMNB2(2), NES(6), RELN(16), SPP1(1), THBS1(8), THBS2(5), THBS3(4), THBS4(2), TNC(7), TNN(12), TNR(15), TNXB(42), VIM(1), VTN(2), VWF(11)	35217132	675	91	667	284	470	58	21	71	55	0	0.00178	1.000	1.000
312	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(5), ADORA1(1), ADORA2A(1), ADORA3(3), ADRA1A(3), ADRA2B(3), ADRA2C(1), AGTR1(2), AGTR2(4), AVPR1B(1), AVPR2(1), BDKRB1(2), BDKRB2(2), BRS3(1), C3AR1(1), C5AR1(3), CALCR(3), CALCRL(5), CCKBR(2), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), CNR1(1), CNR2(1), CRHR1(1), CRHR2(1), CTSG(1), CYSLTR1(2), DRD1(1), DRD2(7), DRD5(8), EDNRA(4), EDNRB(3), F2(2), F2R(1), F2RL1(3), F2RL2(2), F2RL3(2), FPR1(3), FSHB(2), FSHR(5), GABBR1(1), GABBR2(4), GABRA1(5), GABRA2(8), GABRA3(7), GABRA4(4), GABRA6(8), GABRB1(6), GABRB2(8), GABRB3(3), GABRE(9), GABRG1(7), GABRG2(7), GABRG3(3), GABRQ(2), GABRR1(2), GALR1(2), GALR3(1), GH1(2), GH2(2), GHR(8), GHRHR(1), GHSR(3), GLP1R(4), GLP2R(4), GLRA1(4), GLRA2(4), GLRA3(1), GLRB(2), GNRHR(1), GPR156(1), GPR50(4), GPR63(1), GPR83(2), GRIA1(10), GRIA2(14), GRIA3(6), GRIA4(8), GRID1(6), GRID2(14), GRIK1(9), GRIK2(7), GRIK3(12), GRIK4(4), GRIK5(3), GRIN2A(27), GRIN2B(16), GRIN2C(2), GRIN2D(1), GRIN3A(7), GRIN3B(1), GRM1(4), GRM2(1), GRM3(11), GRM4(3), GRM5(3), GRM6(4), GRM7(6), GRM8(17), GRPR(2), GZMA(4), HCRTR1(2), HCRTR2(6), HRH1(3), HRH4(3), HTR1A(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(3), HTR4(3), HTR5A(3), HTR7(3), LEP(1), LEPR(4), LHCGR(7), LTB4R2(1), MAS1(1), MC2R(1), MC3R(1), MC5R(3), MCHR2(6), MTNR1A(1), MTNR1B(2), NMBR(4), NMUR1(4), NMUR2(3), NPBWR1(1), NPBWR2(1), NPFFR1(1), NPFFR2(4), NPY1R(9), NPY2R(3), NPY5R(8), NTSR1(2), NTSR2(1), OPRD1(2), OPRK1(5), OPRL1(3), OPRM1(1), OXTR(1), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY14(1), P2RY6(1), P2RY8(1), PARD3(4), PPYR1(2), PRLHR(1), PRLR(9), PRSS3(1), PTAFR(1), PTGDR(3), PTGER2(2), PTGER3(2), PTGFR(1), PTGIR(1), PTH2R(5), RXFP1(3), RXFP2(11), SCTR(2), SSTR1(3), SSTR2(1), SSTR3(5), SSTR5(2), TAAR2(2), TAAR6(1), TAAR8(2), TACR1(3), TACR2(1), TACR3(8), THRA(1), THRB(5), TSHB(1), TSHR(5), VIPR1(1)	31107192	653	91	635	354	449	51	23	77	52	1	8.28e-06	1.000	1.000
313	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(4), CD44(2), CD47(1), COL11A1(17), COL11A2(8), COL1A1(15), COL1A2(13), COL2A1(9), COL3A1(20), COL4A1(14), COL4A2(8), COL4A4(22), COL4A6(6), COL5A1(10), COL5A2(12), COL5A3(16), COL6A1(1), COL6A2(6), COL6A3(16), COL6A6(13), DAG1(1), FN1(9), FNDC1(6), FNDC3A(2), FNDC5(1), GP9(1), HSPG2(9), IBSP(4), ITGA1(3), ITGA10(1), ITGA11(6), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGAV(2), ITGB1(1), ITGB3(3), ITGB4(5), ITGB6(1), ITGB7(1), ITGB8(4), LAMA1(7), LAMA2(12), LAMA3(16), LAMA4(3), LAMA5(5), LAMB1(1), LAMB2(1), LAMB3(2), LAMB4(9), LAMC1(6), LAMC2(4), LAMC3(2), RELN(16), SDC1(1), SDC2(1), SDC3(4), SDC4(1), SPP1(1), SV2A(1), SV2B(8), SV2C(3), THBS1(8), THBS2(5), THBS3(4), THBS4(2), TNC(7), TNN(12), TNR(15), TNXB(42), VTN(2), VWF(11)	31894111	527	90	524	226	361	35	22	59	50	0	0.112	1.000	1.000
314	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), ACVR1B(1), ACVR2A(2), ACVR2B(2), AMHR2(5), BMP2(1), BMPR1A(1), BMPR2(2), CCL11(1), CCL18(1), CCL20(1), CCL24(2), CCL27(1), CCL7(1), CCR2(2), CCR3(5), CCR4(4), CCR6(1), CCR7(1), CCR8(2), CCR9(1), CD40(2), CNTF(1), CSF1(4), CSF1R(4), CSF2RA(5), CSF2RB(6), CX3CL1(1), CX3CR1(5), CXCL10(2), CXCL13(1), CXCR3(1), CXCR6(1), EDA(1), EDA2R(2), EGF(3), EGFR(4), EPO(2), FAS(1), FASLG(4), FLT1(8), FLT3(10), FLT3LG(2), FLT4(3), GDF5(5), GH1(2), GH2(2), GHR(8), HGF(7), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNAR1(1), IFNAR2(5), IFNB1(2), IFNG(1), IFNGR1(1), IFNGR2(2), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11RA(1), IL12RB1(3), IL13RA1(1), IL15(1), IL15RA(3), IL17A(5), IL17B(1), IL18R1(4), IL18RAP(4), IL1A(1), IL1B(2), IL1R1(2), IL1R2(1), IL1RAP(1), IL20RA(2), IL21(2), IL21R(3), IL22RA1(4), IL23R(4), IL28B(1), IL28RA(1), IL29(1), IL2RA(1), IL2RB(2), IL3(2), IL3RA(3), IL4R(6), IL5(1), IL5RA(3), IL6R(1), IL6ST(5), IL7(2), IL7R(10), IL9R(1), INHBA(5), INHBB(2), INHBC(5), INHBE(1), KDR(8), LEP(1), LEPR(4), LIFR(11), LTB(1), MET(8), MPL(2), OSM(1), OSMR(10), PDGFC(3), PDGFRA(5), PDGFRB(3), PPBP(1), PRLR(9), TGFB3(2), TGFBR2(2), TNFRSF10A(3), TNFRSF11A(2), TNFRSF11B(3), TNFRSF13B(1), TNFRSF17(1), TNFRSF18(2), TNFRSF19(1), TNFRSF21(1), TNFRSF25(1), TNFRSF6B(2), TNFRSF8(7), TNFSF10(3), TNFSF11(2), TNFSF14(1), TNFSF15(2), TNFSF18(1), TNFSF8(1), TPO(12), VEGFA(2), VEGFB(1), VEGFC(6), XCL1(1), XCR1(1)	25132820	391	88	388	202	261	29	15	47	39	0	0.118	1.000	1.000
315	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY7(1), ADCY8(13), ADCY9(5), ADORA2A(1), ADRA1A(3), ADRA1D(1), AGTR1(2), ATP2A1(3), ATP2A2(6), ATP2A3(5), ATP2B1(1), ATP2B2(8), ATP2B3(1), ATP2B4(4), AVPR1B(1), BDKRB1(2), BDKRB2(2), CACNA1A(7), CACNA1B(5), CACNA1C(7), CACNA1D(4), CACNA1E(21), CACNA1F(1), CACNA1G(9), CACNA1H(8), CACNA1I(7), CACNA1S(17), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CCKBR(2), CHP(1), CHRM2(3), CHRM3(8), CHRM5(1), CHRNA7(1), CYSLTR1(2), DRD1(1), EDNRA(4), EDNRB(3), EGFR(4), ERBB2(1), ERBB3(2), ERBB4(15), F2R(1), GNA15(3), GNAL(2), GNAQ(1), GNAS(5), GRIN2A(27), GRIN2C(2), GRIN2D(1), GRM1(4), GRM5(3), GRPR(2), HRH1(3), HTR2A(1), HTR2C(3), HTR4(3), HTR5A(3), HTR7(3), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), LHCGR(7), LTB4R2(1), MYLK(9), MYLK2(2), NOS1(17), NOS3(6), NTSR1(2), OXTR(1), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(13), PDE1B(5), PDE1C(10), PDGFRA(5), PDGFRB(3), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(1), PHKG2(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCD4(2), PLCE1(10), PLCG1(6), PLCG2(6), PLCZ1(5), PPID(1), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), PTAFR(1), PTGER3(2), PTGFR(1), PTK2B(4), RYR1(27), RYR2(30), RYR3(22), SLC25A6(1), SLC8A1(5), SLC8A2(1), SLC8A3(5), SPHK1(1), SPHK2(1), TACR1(3), TACR2(1), TACR3(8), TNNC2(2), TRPC1(2)	37727402	615	86	609	365	427	46	22	65	55	0	0.0206	1.000	1.000
316	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(1), ACVR1C(1), AKT1(3), AKT2(2), AKT3(1), ARRB1(1), ARRB2(1), ATF2(2), ATF4(2), BDNF(1), CACNA1A(7), CACNA1B(5), CACNA1C(7), CACNA1D(4), CACNA1E(21), CACNA1F(1), CACNA1G(9), CACNA1H(8), CACNA1I(7), CACNA1S(17), CACNA2D1(2), CACNA2D2(3), CACNA2D3(14), CACNA2D4(4), CACNB1(1), CACNB2(4), CACNB3(1), CACNB4(3), CACNG1(1), CACNG2(3), CACNG3(3), CACNG5(4), CACNG6(3), CACNG7(1), CASP3(1), CD14(1), CDC42(2), CHP(1), CHUK(1), CRKL(1), DAXX(1), DDIT3(1), DUSP14(1), DUSP16(2), DUSP3(1), DUSP6(1), DUSP7(1), DUSP8(2), ECSIT(1), EGF(3), EGFR(4), ELK1(1), ELK4(2), FAS(1), FASLG(4), FGF1(1), FGF10(1), FGF11(1), FGF12(3), FGF13(2), FGF16(2), FGF17(1), FGF18(2), FGF19(1), FGF21(1), FGF23(2), FGF4(1), FGF5(1), FGF6(1), FGF7(5), FGF9(2), FGFR1(4), FGFR2(7), FGFR3(4), FGFR4(2), FLNA(6), FLNB(8), FLNC(15), FOS(1), GNA12(1), GRB2(1), IKBKB(3), IL1A(1), IL1B(2), IL1R1(2), IL1R2(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAP3K1(1), MAP3K10(5), MAP3K12(1), MAP3K13(4), MAP3K2(3), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP4K1(3), MAP4K2(2), MAP4K3(2), MAP4K4(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK7(1), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), MAPKAPK2(2), MAPKAPK5(1), MAPT(1), MKNK1(2), MOS(1), MRAS(1), NF1(2), NFATC2(2), NFATC4(1), NFKB1(1), NFKB2(2), NLK(1), NR4A1(2), NRAS(1), NTF3(3), NTRK1(5), PAK1(2), PAK2(5), PDGFA(1), PDGFRA(5), PDGFRB(3), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PPM1B(4), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PPP5C(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), PTPN5(3), PTPN7(1), PTPRR(4), RAF1(3), RAPGEF2(2), RASA1(1), RASA2(4), RASGRF1(6), RASGRF2(4), RASGRP2(3), RASGRP3(3), RASGRP4(4), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA4(2), RPS6KA5(1), RPS6KA6(7), SOS1(3), SOS2(4), STK4(1), TAOK1(4), TAOK2(9), TAOK3(2), TGFB3(2), TGFBR2(2), TRAF6(1)	39717328	494	85	487	292	300	42	18	88	46	0	0.791	1.000	1.000
317	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	ACTN1(1), ACTN2(4), ACTN4(1), APC(6), APC2(3), ARAF(1), ARHGEF12(4), ARHGEF4(2), ARHGEF6(5), ARPC2(1), ARPC4(1), BAIAP2(3), BCAR1(1), BDKRB1(2), BDKRB2(2), CD14(1), CDC42(2), CFL1(1), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), CRKL(1), CSK(1), CYFIP1(1), CYFIP2(5), DIAPH2(2), DIAPH3(3), DOCK1(2), EGF(3), EGFR(4), F2(2), F2R(1), FGD3(1), FGF1(1), FGF10(1), FGF11(1), FGF12(3), FGF13(2), FGF16(2), FGF17(1), FGF18(2), FGF19(1), FGF21(1), FGF23(2), FGF4(1), FGF5(1), FGF6(1), FGF7(5), FGF9(2), FGFR1(4), FGFR2(7), FGFR3(4), FGFR4(2), FN1(9), GNA12(1), GRLF1(2), IQGAP1(2), IQGAP2(7), IQGAP3(2), ITGA1(3), ITGA10(1), ITGA11(6), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGAD(8), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(2), ITGAX(6), ITGB1(1), ITGB2(2), ITGB3(3), ITGB4(5), ITGB6(1), ITGB7(1), ITGB8(4), LIMK2(1), MAP2K1(3), MAP2K2(2), MAPK1(1), MOS(1), MRAS(1), MYH10(4), MYH14(5), MYH9(6), MYL2(1), MYL5(1), MYL7(1), MYL9(1), MYLK(9), MYLK2(2), NCKAP1(2), NCKAP1L(7), NRAS(1), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PDGFA(1), PDGFRA(5), PDGFRB(3), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1A(1), PIP5K1B(4), PIP5K1C(2), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(4), PTK2(2), PXN(1), RAF1(3), RDX(1), RHOA(1), ROCK1(2), ROCK2(6), SCIN(1), SOS1(3), SOS2(4), SSH1(6), SSH3(2), TIAM1(2), TIAM2(5), VAV1(5), VAV3(1), VCL(2), WAS(2), WASF1(2), WASF2(3), WASL(1)	38813274	437	85	434	191	255	25	22	83	51	1	0.00713	1.000	1.000
318	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(6), ABLIM1(1), ABLIM2(1), ABLIM3(3), ARHGEF12(4), CDC42(2), CDK5(1), CFL1(1), CHP(1), DCC(21), DPYSL2(1), DPYSL5(2), EFNA4(2), EFNA5(1), EFNB1(1), EFNB3(1), EPHA1(4), EPHA2(4), EPHA3(9), EPHA4(2), EPHA5(1), EPHA6(20), EPHA7(7), EPHA8(4), EPHB1(3), EPHB2(8), EPHB3(3), EPHB4(1), EPHB6(8), FES(2), FYN(1), GNAI1(1), GNAI3(1), GSK3B(1), ITGB1(1), L1CAM(2), LIMK2(1), LRRC4C(12), MAPK1(1), MET(8), NCK2(2), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NGEF(4), NRAS(1), NRP1(4), NTN4(5), NTNG1(6), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PLXNA1(6), PLXNA2(2), PLXNA3(1), PLXNB1(5), PLXNB2(5), PLXNB3(2), PLXNC1(4), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PTK2(2), RASA1(1), RGS3(4), RHOA(1), RND1(2), ROBO1(9), ROBO2(12), ROBO3(5), ROCK1(2), ROCK2(6), SEMA3A(3), SEMA3C(2), SEMA3D(3), SEMA3E(5), SEMA3F(2), SEMA3G(2), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(2), SEMA4F(3), SEMA4G(1), SEMA5A(2), SEMA5B(6), SEMA6A(3), SEMA6B(1), SEMA6C(3), SEMA6D(2), SEMA7A(1), SLIT1(3), SLIT2(18), SLIT3(15), SRGAP1(1), SRGAP2(2), SRGAP3(8), UNC5B(1), UNC5C(6), UNC5D(3)	27666434	393	84	388	216	265	28	10	61	29	0	0.451	1.000	1.000
319	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(2), AKT3(1), CBL(1), CBLB(4), CBLC(3), CCND2(1), CCND3(1), CISH(2), CNTF(1), CREBBP(4), CSF2RA(5), CSF2RB(6), EP300(1), EPO(2), GH1(2), GH2(2), GHR(8), GRB2(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNAR1(1), IFNAR2(5), IFNB1(2), IFNG(1), IFNGR1(1), IFNGR2(2), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11RA(1), IL12RB1(3), IL13RA1(1), IL13RA2(2), IL15(1), IL15RA(3), IL20RA(2), IL21(2), IL21R(3), IL22RA1(4), IL23R(4), IL28B(1), IL28RA(1), IL29(1), IL2RA(1), IL2RB(2), IL3(2), IL3RA(3), IL4R(6), IL5(1), IL5RA(3), IL6R(1), IL6ST(5), IL7(2), IL7R(10), IL9R(1), JAK1(2), JAK2(2), JAK3(1), LEP(1), LEPR(4), LIFR(11), MPL(2), OSM(1), OSMR(10), PIAS1(3), PIAS2(2), PIAS3(2), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PIM1(1), PRLR(9), PTPN11(2), PTPN6(2), SOCS2(1), SOCS3(1), SOCS5(1), SOS1(3), SOS2(4), SPRED1(1), SPRED2(1), SPRY1(1), SPRY2(3), SPRY3(5), STAM(1), STAM2(1), STAT2(4), STAT3(6), STAT4(9), STAT5A(1), STAT5B(1), STAT6(1), TPO(12), TYK2(1)	20687913	294	84	292	127	173	20	16	53	31	1	0.0989	1.000	1.000
320	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(6), APC2(3), AXIN1(3), AXIN2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CCND2(1), CCND3(1), CER1(5), CHD8(5), CHP(1), CREBBP(4), CSNK1A1(1), CSNK1A1L(1), CSNK1E(1), CSNK2B(1), CTBP2(1), CTNNB1(6), CTNNBIP1(1), CUL1(2), DAAM1(2), DAAM2(2), DKK1(1), DKK2(2), DKK4(1), DVL3(4), EP300(1), FBXW11(1), FZD1(2), FZD2(2), FZD8(3), FZD9(1), GSK3B(1), JUN(1), LEF1(1), LRP5(3), LRP6(9), MAPK10(2), MAPK9(1), MMP7(1), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NKD1(3), NKD2(3), NLK(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PORCN(3), PPP2R1A(1), PPP2R1B(1), PPP2R2B(1), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRICKLE1(3), PRICKLE2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), PSEN1(1), RHOA(1), ROCK1(2), ROCK2(6), SENP2(3), SFRP2(3), SFRP4(3), SMAD2(1), SMAD3(1), SMAD4(2), TBL1X(3), TBL1Y(2), TCF7L1(1), TCF7L2(3), VANGL2(5), WNT1(1), WNT10A(1), WNT10B(2), WNT11(1), WNT2(1), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(5), WNT7B(1), WNT8A(3), WNT8B(1), WNT9A(2), WNT9B(1)	22615898	250	83	246	107	138	24	10	49	29	0	0.0908	1.000	1.000
321	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(1), ACTN2(4), ACTN4(1), DES(1), DMD(9), FAM48A(1), MYBPC1(1), MYBPC2(6), MYBPC3(5), MYH3(6), MYH6(10), MYH7(10), MYH8(14), MYL1(1), MYL2(1), MYL9(1), MYOM1(5), NEB(27), TCAP(1), TNNC2(2), TNNI3(1), TNNT2(1), TPM1(1), TPM2(2), TPM3(2), TPM4(2), TTN(291), VIM(1)	19152984	408	81	396	170	293	24	14	51	23	3	0.00606	1.000	1.000
322	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), ADRA1A(3), ADRA1D(1), ANXA6(2), ARRB1(1), ARRB2(1), ATP1A4(3), ATP1B3(1), ATP2A2(6), ATP2A3(5), ATP2B1(1), ATP2B2(8), ATP2B3(1), CACNA1A(7), CACNA1B(5), CACNA1C(7), CACNA1D(4), CACNA1E(21), CACNA1S(17), CACNB1(1), CACNB3(1), CALM2(1), CALR(1), CAMK1(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CASQ1(3), CASQ2(1), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), GJA1(1), GJA5(2), GJB3(1), GJB4(4), GJB6(1), GNAI3(1), GNAQ(1), GNAZ(2), GNB3(1), GNG2(1), GNG7(1), GRK4(3), GRK6(2), ITPR1(10), ITPR2(3), ITPR3(3), KCNB1(10), KCNJ3(5), KCNJ5(3), MIB1(2), NME7(1), PKIA(1), PKIB(1), PLCB3(2), PRKACA(2), PRKACB(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCQ(2), PRKD1(1), RGS1(1), RGS18(2), RGS3(4), RGS6(4), RGS7(13), RGS9(3), RYR1(27), RYR2(30), RYR3(22), SLC8A1(5), SLC8A3(5), YWHAB(1), YWHAQ(1)	26447165	373	80	365	253	251	39	13	38	32	0	0.628	1.000	1.000
323	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(4), CADM3(7), CD2(6), CD22(5), CD226(2), CD276(2), CD4(5), CD40(2), CD6(1), CD80(3), CD86(3), CD8A(1), CDH1(3), CDH2(6), CDH4(6), CDH5(2), CLDN1(3), CLDN10(2), CLDN11(1), CLDN16(4), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN6(3), CLDN9(1), CNTN1(9), CNTN2(5), CNTNAP1(5), CNTNAP2(17), F11R(3), GLG1(3), HLA-B(1), HLA-DMB(4), HLA-DOB(1), HLA-DPA1(1), HLA-DQA1(2), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-F(1), HLA-G(1), ICAM2(1), ICOS(1), ICOSLG(1), ITGA4(10), ITGA6(3), ITGA8(7), ITGA9(4), ITGAL(6), ITGAM(3), ITGAV(2), ITGB1(1), ITGB2(2), ITGB7(1), ITGB8(4), JAM2(4), JAM3(2), L1CAM(2), MADCAM1(1), MAG(2), MPZ(1), NCAM1(5), NCAM2(5), NEGR1(3), NEO1(3), NFASC(10), NLGN1(5), NLGN2(2), NLGN3(2), NRCAM(2), NRXN1(14), NRXN2(4), NRXN3(8), PDCD1(1), PDCD1LG2(1), PTPRC(16), PTPRF(7), PTPRM(3), PVR(1), PVRL1(1), PVRL2(1), SDC1(1), SDC2(1), SDC3(4), SDC4(1), SELE(4), SELL(3), SELP(11), SELPLG(3), SIGLEC1(4), SPN(2), VCAM1(3), VCAN(6)	20840174	332	80	325	129	213	27	17	59	16	0	0.000565	1.000	1.000
324	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(1), ADORA2A(1), ADORA3(3), ADRA1A(3), ADRA1D(1), ADRA2C(1), AGTR1(2), AGTR2(4), AVPR1B(1), AVPR2(1), BDKRB1(2), BDKRB2(2), BRS3(1), C3AR1(1), CCBP2(3), CCKBR(2), CCR10(1), CCR2(2), CCR3(5), CCR4(4), CCR6(1), CCR7(1), CCR8(2), CCR9(1), CCRL2(2), CHML(3), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), CMKLR1(3), CNR1(1), CNR2(1), CX3CR1(5), CXCR3(1), DRD1(1), DRD2(7), DRD5(8), EDNRA(4), EDNRB(3), F2R(1), F2RL1(3), F2RL2(2), F2RL3(2), FPR1(3), FSHR(5), GALR1(2), GALR3(1), GALT(1), GHSR(3), GPR173(1), GPR174(3), GPR37(4), GPR37L1(2), GPR50(4), GPR6(1), GPR63(1), GPR77(2), GPR83(2), GPR85(3), GPR87(2), GRPR(2), HCRTR1(2), HCRTR2(6), HRH1(3), HTR1A(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(3), HTR4(3), HTR5A(3), HTR7(3), LHCGR(7), MAS1(1), MC3R(1), MC5R(3), MTNR1A(1), MTNR1B(2), NMBR(4), NMUR1(4), NMUR2(3), NPY1R(9), NPY2R(3), NPY5R(8), NTSR1(2), NTSR2(1), OPN3(2), OPRD1(2), OPRK1(5), OPRL1(3), OPRM1(1), OR10A5(2), OR11A1(4), OR12D3(2), OR1C1(2), OR1F1(2), OR1Q1(3), OR2H1(3), OR5V1(1), OR8B8(4), OXTR(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY14(1), P2RY6(1), PPYR1(2), PTAFR(1), PTGDR(3), PTGER2(2), PTGFR(1), PTGIR(1), RGR(3), SSTR1(3), SSTR2(1), SSTR3(5), SUCNR1(3)	17091509	292	79	289	200	189	29	10	45	19	0	0.0231	1.000	1.000
325	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(3), ACTG1(1), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(1), ASH1L(7), CASK(1), CDC42(2), CGN(4), CLDN1(3), CLDN10(2), CLDN11(1), CLDN16(4), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN6(3), CLDN9(1), CRB3(1), CSNK2B(1), CTNNA2(3), CTNNA3(4), CTNNB1(6), EPB41(4), EPB41L1(3), EPB41L2(5), EPB41L3(2), EXOC3(1), EXOC4(5), F11R(3), GNAI1(1), GNAI3(1), HCLS1(1), IGSF5(3), INADL(13), JAM2(4), JAM3(2), LLGL1(2), LLGL2(2), MAGI1(11), MAGI2(4), MAGI3(8), MLLT4(2), MPDZ(2), MPP5(1), MRAS(1), MYH1(29), MYH10(4), MYH11(5), MYH13(12), MYH14(5), MYH15(13), MYH2(17), MYH3(6), MYH4(19), MYH6(10), MYH7(10), MYH7B(9), MYH8(14), MYH9(6), MYL2(1), MYL5(1), MYL7(1), MYL9(1), NRAS(1), PARD3(4), PARD6G(1), PPP2R1A(1), PPP2R1B(1), PPP2R2B(1), PPP2R3A(1), PPP2R3B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCI(3), PRKCQ(2), RAB3B(1), RHOA(1), SPTAN1(2), SYMPK(2), TJP1(4), TJP2(2), TJP3(5), YES1(4)	27287911	361	79	357	208	234	29	10	52	36	0	0.377	1.000	1.000
326	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(1), ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), ARRB1(1), ARRB2(1), ATF1(3), ATF2(2), ATF4(2), ATF5(3), ATP2A2(6), ATP2A3(5), CACNB3(1), CALCA(2), CALM2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CORIN(3), CRH(2), CRHR1(1), DGKZ(2), ETS2(2), FOS(1), GABPB2(2), GBA2(1), GJA1(1), GNAQ(1), GNB3(1), GNG2(1), GNG7(1), GRK4(3), GRK6(2), GUCA2A(1), GUCY1A3(6), IGFBP1(1), IGFBP6(2), IL1B(2), ITPR1(10), ITPR2(3), ITPR3(3), JUN(1), MIB1(2), MYL2(1), MYLK2(2), NFKB1(1), NOS1(17), NOS3(6), OXTR(1), PDE4B(3), PDE4D(4), PKIA(1), PKIB(1), PLCB3(2), PLCG1(6), PLCG2(6), PRKACA(2), PRKACB(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCH(4), PRKCQ(2), PRKD1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS18(2), RGS3(4), RGS6(4), RGS7(13), RGS9(3), RYR1(27), RYR2(30), RYR3(22), SLC8A1(5), TNXB(42), YWHAB(1), YWHAQ(1)	24741667	360	79	350	179	248	31	11	42	28	0	0.00797	1.000	1.000
327	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), ADK(2), ADSL(1), ADSS(2), ADSSL1(5), AK2(1), AK5(3), AK7(3), ALLC(2), AMPD1(7), AMPD2(2), AMPD3(7), APRT(2), ATIC(2), CANT1(1), ENPP1(4), ENPP3(4), ENTPD1(2), ENTPD3(2), ENTPD4(1), ENTPD6(1), ENTPD8(1), FHIT(1), GART(2), GDA(4), GUCY1A2(5), GUCY1A3(6), GUCY2C(7), GUCY2D(3), GUCY2F(3), GUK1(2), NME7(1), NPR1(4), NPR2(4), NT5C1A(1), NT5C1B(6), NT5C2(2), NT5E(1), NUDT5(1), NUDT9(1), PAPSS1(1), PDE10A(5), PDE11A(6), PDE1A(13), PDE1C(10), PDE2A(3), PDE3B(3), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(2), PDE6D(1), PDE6G(1), PDE7A(1), PDE7B(5), PDE8A(1), PDE8B(6), PDE9A(5), PFAS(1), PKLR(2), PKM2(1), POLA1(1), POLA2(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLR3B(7), POLR3H(1), PRIM1(2), PRIM2(5), PRPS1(2), PRPS1L1(2), PRPS2(1), RRM1(1), RRM2(2), RRM2B(2), XDH(8)	23272006	289	76	288	141	184	27	19	32	27	0	0.0898	1.000	1.000
328	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(3), AMY2A(1), AMY2B(5), ASCC3(2), ATP13A2(3), DDX18(2), DDX23(3), DDX4(2), DDX41(3), DDX51(2), DDX52(1), DDX54(1), DDX55(1), DHX58(3), ENPP1(4), ENPP3(4), ENTPD7(1), EP400(7), ERCC2(1), ERCC3(1), G6PC2(2), GAA(1), GANC(4), GBA3(4), GBE1(2), GCK(5), GPI(1), GUSB(3), GYS1(2), GYS2(3), HK1(2), HK2(4), HK3(3), IFIH1(7), MGAM(39), MOV10L1(7), NUDT5(1), PGM1(3), PYGL(1), PYGM(1), RAD54B(2), RUVBL2(2), SETX(7), SI(18), SKIV2L2(2), SMARCA2(2), SMARCA5(4), TREH(1), UGDH(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5), UXS1(2)	17236487	251	75	247	107	157	17	11	40	26	0	0.0762	1.000	1.000
329	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(4), CD14(1), CD19(4), CD1A(2), CD1B(6), CD1C(8), CD1E(8), CD2(6), CD22(5), CD33(5), CD37(2), CD4(5), CD44(2), CD55(2), CD8A(1), CR1(14), CR2(8), CSF1(4), CSF1R(4), CSF2RA(5), DNTT(1), EPO(2), FCER2(2), FCGR1A(1), FLT3(10), FLT3LG(2), GP9(1), GYPA(2), HLA-DRA(3), HLA-DRB1(1), IL11RA(1), IL1A(1), IL1B(2), IL1R1(2), IL1R2(1), IL2RA(1), IL3(2), IL3RA(3), IL4R(6), IL5(1), IL5RA(3), IL6R(1), IL7(2), IL7R(10), IL9R(1), ITGA1(3), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGAM(3), ITGB3(3), MME(6), MS4A1(1), TFRC(3), THPO(2), TPO(12)	11570469	217	75	213	87	153	10	11	23	20	0	0.00982	1.000	1.000
330	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(6), ACACB(3), AKT1(3), AKT2(2), AKT3(1), ARAF(1), CALM2(1), CALML3(1), CBL(1), CBLB(4), CBLC(3), CRKL(1), ELK1(1), EXOC7(3), FASN(5), FBP1(1), FBP2(1), FLOT1(1), FOXO1(1), G6PC2(2), GCK(5), GRB2(1), GSK3B(1), GYS1(2), GYS2(3), IKBKB(3), INPP5D(6), INSR(6), IRS1(1), IRS4(3), LIPE(4), MAP2K1(3), MAP2K2(2), MAPK1(1), MAPK10(2), MAPK9(1), MKNK1(2), NRAS(1), PCK1(3), PCK2(1), PDE3A(3), PDE3B(3), PDPK1(1), PFKL(2), PFKM(1), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(1), PHKG2(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PKLR(2), PKM2(1), PPARGC1A(2), PPP1CB(1), PPP1CC(1), PPP1R3A(10), PPP1R3B(3), PPP1R3C(1), PPP1R3D(2), PRKAA2(6), PRKAB1(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAG3(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCI(3), PRKX(1), PTPRF(7), PYGL(1), PYGM(1), RAF1(3), RAPGEF1(3), SHC2(2), SHC3(2), SLC2A4(3), SOCS2(1), SOCS3(1), SORBS1(3), SOS1(3), SOS2(4), SREBF1(1), TRIP10(1), TSC1(1), TSC2(3)	22478023	243	75	240	99	137	17	12	47	29	1	0.0340	1.000	1.000
331	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), DRD1(1), DRD2(7), EGF(3), EGFR(4), GJA1(1), GJD2(1), GNAI1(1), GNAI3(1), GNAQ(1), GNAS(5), GRB2(1), GRM1(4), GRM5(3), GUCY1A2(5), GUCY1A3(6), GUCY2C(7), GUCY2D(3), GUCY2F(3), HTR2A(1), HTR2C(3), ITPR1(10), ITPR2(3), ITPR3(3), MAP2K1(3), MAP2K2(2), MAP3K2(3), MAPK1(1), MAPK7(1), NPR1(4), NPR2(4), NRAS(1), PDGFA(1), PDGFC(3), PDGFD(1), PDGFRA(5), PDGFRB(3), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKG1(2), PRKG2(4), PRKX(1), RAF1(3), SOS1(3), SOS2(4), TJP1(4), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA4A(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB3(1), TUBB4(2), TUBB4Q(3), TUBB6(2), TUBB8(1)	18698473	244	74	239	130	153	24	12	32	23	0	0.188	1.000	1.000
332	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(6), BDKRB1(2), BDKRB2(2), C1QA(2), C1QC(2), C1R(3), C1S(3), C2(3), C3(9), C3AR1(1), C4BPA(5), C4BPB(2), C5(4), C5AR1(3), C6(21), C7(11), C8A(8), C8B(14), C8G(1), C9(4), CD55(2), CFB(4), CFH(8), CFI(3), CR1(14), CR2(8), F10(3), F11(3), F13A1(9), F13B(7), F2(2), F2R(1), F5(9), F7(1), F8(19), F9(2), FGA(8), FGB(5), FGG(3), KLKB1(5), KNG1(2), MASP1(1), MBL2(5), PLAU(1), PLAUR(1), PLG(4), PROC(2), PROS1(7), SERPINA1(2), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPING1(3), TFPI(1), VWF(11)	12858973	267	74	263	102	182	18	13	35	18	1	0.00822	1.000	1.000
333	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(4), ABCA10(10), ABCA12(10), ABCA13(12), ABCA2(3), ABCA3(3), ABCA4(11), ABCA5(2), ABCA6(8), ABCA7(2), ABCA8(10), ABCA9(7), ABCB1(9), ABCB10(3), ABCB11(5), ABCB4(4), ABCB5(12), ABCB6(1), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(4), ABCC10(5), ABCC11(2), ABCC12(6), ABCC2(2), ABCC3(6), ABCC5(5), ABCC6(8), ABCC8(9), ABCC9(18), ABCD2(4), ABCD3(4), ABCD4(1), ABCG1(3), ABCG4(3), ABCG8(3), CFTR(11), TAP2(5)	16810113	219	72	217	135	132	16	6	35	30	0	0.624	1.000	1.000
334	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(12), ADCY8(13), ARAF(1), ATF4(2), CACNA1C(7), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CHP(1), CREBBP(4), EP300(1), GNAQ(1), GRIA1(10), GRIA2(14), GRIN2A(27), GRIN2B(16), GRIN2C(2), GRIN2D(1), GRM1(4), GRM5(3), ITPR1(10), ITPR2(3), ITPR3(3), MAP2K1(3), MAP2K2(2), MAPK1(1), NRAS(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), RAF1(3), RAPGEF3(5), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA6(7)	13791901	242	72	238	122	155	20	11	36	20	0	0.101	1.000	1.000
335	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(1), CACNA1A(7), CRH(2), CRHR1(1), GNA12(1), GNAI1(1), GNAI3(1), GNAQ(1), GNAS(5), GNAZ(2), GRIA1(10), GRIA2(14), GRIA3(6), GRID2(14), GRM1(4), GRM5(3), GUCY1A2(5), GUCY1A3(6), GUCY2C(7), GUCY2D(3), GUCY2F(3), IGF1(5), IGF1R(4), ITPR1(10), ITPR2(3), ITPR3(3), LYN(2), MAP2K1(3), MAP2K2(2), MAPK1(1), NOS1(17), NOS3(6), NPR1(4), NPR2(4), NRAS(1), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PPP2R1A(1), PPP2R1B(1), PPP2R2B(1), PRKCA(2), PRKCG(5), PRKG1(2), PRKG2(4), RAF1(3), RYR1(27)	15339127	257	71	252	118	186	15	7	28	21	0	0.00464	1.000	1.000
336	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), AKAP1(2), AKAP10(2), AKAP11(5), AKAP12(1), AKAP3(6), AKAP4(6), AKAP6(9), AKAP7(1), AKAP8(2), AKAP9(6), CALM2(1), GNA12(1), GNA15(3), GNAI3(1), GNAL(2), GNAQ(1), GNAZ(2), GNB3(1), GNG7(1), GNGT2(1), ITPR1(10), KCNJ3(5), NRAS(1), PDE1A(13), PDE1B(5), PDE1C(10), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(4), PDE7A(1), PDE7B(5), PDE8A(1), PDE8B(6), PLCB3(2), PPP3CA(4), PPP3CC(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCI(3), PRKCQ(2), PRKD1(1), PRKD3(2), RHOA(1)	16632685	208	70	208	84	134	16	11	29	18	0	0.00477	1.000	1.000
337	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(3), BCAR1(1), CDC42(2), CDH5(2), CLDN1(3), CLDN10(2), CLDN11(1), CLDN16(4), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN6(3), CLDN9(1), CTNNA2(3), CTNNA3(4), CTNNB1(6), CTNND1(1), CYBB(2), F11R(3), GNAI1(1), GNAI3(1), GRLF1(2), ITGA4(10), ITGAL(6), ITGAM(3), ITGB1(1), ITGB2(2), ITK(2), JAM2(4), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MLLT4(2), MMP2(3), MYL2(1), MYL5(1), MYL7(1), MYL9(1), NCF2(2), NCF4(2), NOX1(3), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG1(6), PLCG2(6), PRKCA(2), PRKCG(5), PTK2(2), PTK2B(4), PTPN11(2), PXN(1), RAPGEF3(5), RAPGEF4(2), RASSF5(2), RHOA(1), RHOH(4), ROCK1(2), ROCK2(6), SIPA1(2), VASP(1), VAV1(5), VAV3(1), VCAM1(3), VCL(2)	17517996	208	70	208	89	118	14	9	49	17	1	0.0586	1.000	1.000
338	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), AKR1C2(1), AKR1C3(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), CYP1A1(2), CYP1A2(5), CYP1B1(1), CYP2B6(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2F1(4), CYP2S1(2), CYP3A4(8), CYP3A43(7), CYP3A5(5), CYP3A7(1), DHDH(1), GSTA1(2), GSTM3(1), GSTM5(1), GSTP1(1), MGST1(1), MGST2(1), MGST3(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5)	7881882	184	69	179	75	138	14	7	15	10	0	0.00126	1.000	1.000
339	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(6), ANAPC1(8), ANAPC4(1), ANAPC5(2), ANAPC7(3), ATM(6), ATR(6), BUB1(1), BUB1B(5), CCNA1(8), CCNB2(3), CCNB3(8), CCND2(1), CCND3(1), CCNE1(1), CCNE2(5), CDC14A(2), CDC23(2), CDC25A(1), CDC7(1), CDK6(1), CDKN1A(1), CHEK1(1), CHEK2(1), CREBBP(4), CUL1(2), DBF4(4), E2F2(1), E2F3(4), EP300(1), ESPL1(4), FZR1(2), GSK3B(1), HDAC1(1), HDAC2(1), MAD2L2(1), MCM2(2), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MDM2(2), ORC1L(1), ORC4L(1), PCNA(2), PKMYT1(2), PLK1(1), PRKDC(6), PTTG2(2), RB1(2), RBL1(5), RBL2(2), SMAD2(1), SMAD3(1), SMAD4(2), SMC1A(1), SMC1B(11), TGFB3(2), YWHAB(1), YWHAQ(1)	19168838	154	69	153	62	74	10	10	48	11	1	0.318	1.000	1.000
340	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(3), AKT2(2), AKT3(1), CASP8(4), CD14(1), CD40(2), CD80(3), CD86(3), CHUK(1), CXCL10(2), FOS(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNAR1(1), IFNAR2(5), IFNB1(2), IKBKB(3), IKBKE(4), IL1B(2), IRAK1(3), IRAK4(1), IRF3(1), IRF7(2), JUN(1), LBP(2), LY96(3), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(1), NFKB1(1), NFKB2(2), NFKBIA(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), RELA(2), SPP1(1), TBK1(2), TICAM1(2), TIRAP(1), TLR1(4), TLR2(2), TLR3(4), TLR4(6), TLR5(3), TLR6(4), TLR7(8), TLR9(3), TOLLIP(1), TRAF3(2), TRAF6(1)	12677316	172	69	169	56	86	14	11	43	17	1	0.00158	1.000	1.000
341	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), ATF4(2), CACNA1C(7), CACNA1D(4), CACNA1F(1), CACNA1S(17), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CDC42(2), EGFR(4), ELK1(1), FSHB(2), GNAQ(1), GNAS(5), GNRH2(1), GNRHR(1), GRB2(1), HBEGF(1), ITPR1(10), ITPR2(3), ITPR3(3), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAP3K1(1), MAP3K2(3), MAP3K3(2), MAP3K4(5), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK7(1), MAPK9(1), MMP2(3), NRAS(1), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLD1(5), PLD2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCD(2), PRKX(1), PTK2B(4), RAF1(3), SOS1(3), SOS2(4)	17901252	235	69	231	133	138	27	14	33	23	0	0.306	1.000	1.000
342	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(5), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CREB3L3(3), CREB3L4(3), CREBBP(4), CTNNB1(6), DCT(1), DVL3(4), EDN1(3), EDNRB(3), EP300(1), FZD1(2), FZD2(2), FZD8(3), FZD9(1), GNAI1(1), GNAI3(1), GNAQ(1), GNAS(5), GSK3B(1), LEF1(1), MAP2K1(3), MAP2K2(2), MAPK1(1), MITF(1), NRAS(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PRKACA(2), PRKACB(3), PRKACG(3), PRKCA(2), PRKCG(5), PRKX(1), RAF1(3), TCF7L1(1), TCF7L2(3), TYR(4), TYRP1(3), WNT1(1), WNT10A(1), WNT10B(2), WNT11(1), WNT2(1), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(5), WNT7B(1), WNT8A(3), WNT8B(1), WNT9A(2), WNT9B(1)	15336904	197	69	192	96	110	20	11	27	29	0	0.100	1.000	1.000
343	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(3), ALG1(1), ALG10(1), ALG10B(3), ALG12(1), ALG13(3), ALG14(1), ALG2(2), ALG3(1), ALG6(1), ALG8(4), ALG9(4), B3GNT1(2), B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), C1GALT1(1), CHPF(2), CHST1(1), CHST11(3), CHST12(1), CHST13(1), CHST14(1), CHST4(3), CHST6(1), CHSY1(2), DDOST(1), DPAGT1(1), EXT2(3), EXTL1(1), EXTL3(3), FUT11(1), FUT8(2), GALNT1(1), GALNT10(5), GALNT12(2), GALNT13(7), GALNT14(5), GALNT2(1), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(5), GALNT9(2), GALNTL1(1), GALNTL2(3), GALNTL4(2), GALNTL5(6), GANAB(2), GCNT1(3), GCNT3(4), GCNT4(1), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(2), HS6ST3(4), MAN1A1(5), MAN1A2(1), MAN2A1(4), MGAT1(1), MGAT3(2), MGAT4A(3), MGAT4B(1), MGAT5B(5), NDST1(1), NDST2(1), NDST3(7), NDST4(15), OGT(2), ST3GAL2(1), ST3GAL3(1), ST6GAL1(1), ST6GALNAC1(2), STT3B(2), XYLT1(2), XYLT2(1)	15359265	189	68	187	76	123	14	7	21	24	0	0.00587	1.000	1.000
344	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(3), AKT2(2), AKT3(1), CARD11(5), CBL(1), CBLB(4), CBLC(3), CD4(5), CD8A(1), CDC42(2), CHP(1), CHUK(1), FOS(1), FYN(1), GRAP2(1), GRB2(1), ICOS(1), IFNG(1), IKBKB(3), IL10(1), IL5(1), ITK(2), JUN(1), LAT(1), LCK(1), LCP2(4), MALT1(1), NCK2(2), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB1(1), NFKB2(2), NFKBIA(1), NRAS(1), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PDCD1(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKCQ(2), PTPN6(2), PTPRC(16), RHOA(1), SOS1(3), SOS2(4), TEC(4), VAV1(5), VAV3(1)	14337750	185	66	183	59	104	11	13	44	12	1	0.00322	1.000	1.000
345	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT1(3), AKT3(1), BCAR1(1), CAPN1(2), CAPN10(3), CAPN11(3), CAPN2(2), CAPN3(2), CAPN5(1), CAPN6(3), CAPN7(1), CAPN9(4), CDC42(2), CSK(1), DOCK1(2), FYN(1), GIT2(2), GRB2(1), ITGA10(1), ITGA11(6), ITGA2(2), ITGA2B(5), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGAD(8), ITGAE(3), ITGAL(6), ITGAM(3), ITGAV(2), ITGAX(6), ITGB1(1), ITGB2(2), ITGB3(3), ITGB4(5), ITGB6(1), ITGB7(1), ITGB8(4), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(1), MAPK10(2), MAPK12(1), MAPK4(5), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PDPK1(1), PIK3R2(3), PTK2(2), PXN(1), RAPGEF1(3), ROCK1(2), ROCK2(6), SHC3(2), SORBS1(3), SOS1(3), TLN1(2), TNS1(3), VASP(1), VAV3(1), VCL(2), ZYX(2)	18804897	202	66	200	84	116	18	13	37	18	0	0.0337	1.000	1.000
346	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(12), ADCY2(2), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(13), ADK(2), ADSL(1), ADSS(2), AK2(1), AK5(3), ALLC(2), AMPD1(7), AMPD2(2), AMPD3(7), APRT(2), ATIC(2), ATP5C1(1), ATP5F1(2), ATP5J(1), CANT1(1), ENPP1(4), ENPP3(4), ENTPD1(2), FHIT(1), GART(2), GDA(4), GUCY1A2(5), GUCY1A3(6), GUCY2C(7), GUCY2D(3), GUCY2F(3), GUK1(2), NPR1(4), NPR2(4), NT5E(1), PAPSS1(1), PDE1A(13), PDE4A(3), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(2), PDE6B(2), PDE6C(7), PDE6G(1), PDE7B(5), PDE8A(1), PDE9A(5), PFAS(1), PKLR(2), PKM2(1), POLD1(2), POLE(4), POLG(4), POLL(1), POLQ(7), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLRMT(1), PRPS1(2), PRPS1L1(2), PRPS2(1), RRM1(1), RRM2(2)	18200006	218	66	217	106	143	16	10	26	23	0	0.0913	1.000	1.000
347	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM2(1), CALML3(1), CDS1(2), CDS2(2), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKI(11), DGKQ(3), DGKZ(2), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(3), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(6), INPPL1(5), ITPK1(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), OCRL(1), PI4KA(2), PI4KB(1), PIK3C2A(2), PIK3C2B(4), PIK3C2G(10), PIK3C3(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1A(1), PIP5K1B(4), PIP5K1C(2), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCD4(2), PLCE1(10), PLCG1(6), PLCG2(6), PLCZ1(5), PRKCA(2), PRKCG(5), SYNJ1(7), SYNJ2(2)	17494305	231	65	228	91	142	12	11	43	22	1	0.00433	1.000	1.000
348	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(6), ACTN1(1), AKT1(3), AKT2(2), AKT3(1), ANGPTL2(1), ARHGEF6(5), BCAR1(1), CDC42(2), CSE1L(3), DOCK1(2), EPHB2(8), FYN(1), GRB2(1), GRB7(1), GRLF1(2), ITGA1(3), ITGA10(1), ITGA11(6), ITGA2(2), ITGA3(2), ITGA4(10), ITGA5(4), ITGA6(3), ITGA7(5), ITGA8(7), ITGA9(4), ITGB3BP(1), MAP2K4(1), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), MRAS(1), MYLK(9), MYLK2(2), P4HB(1), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PIK3CA(3), PIK3CB(9), PKLR(2), PLCG1(6), PLCG2(6), PTK2(2), RAF1(3), RALA(1), ROCK1(2), ROCK2(6), SOS1(3), SOS2(4), TLN1(2), TLN2(11), VASP(1), WAS(2), ZYX(2)	16886959	198	65	198	78	110	15	13	45	15	0	0.0294	1.000	1.000
349	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(3), AMY2A(1), AMY2B(5), ENPP1(4), ENPP3(4), GAA(1), GANAB(2), GBA3(4), GBE1(2), GCK(5), GPI(1), GUSB(3), GYS1(2), GYS2(3), HK1(2), HK2(4), HK3(3), MGAM(39), PGM1(3), PYGL(1), PYGM(1), SI(18), UGDH(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2B4(7), UXS1(2)	7796942	138	65	138	63	89	9	6	21	13	0	0.219	1.000	1.000
350	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(6), ABL2(1), AKT1(3), AKT2(2), AKT3(1), ARAF(1), AREG(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CBL(1), CBLB(4), CBLC(3), CDKN1A(1), CRKL(1), EGF(3), EGFR(4), ELK1(1), ERBB2(1), ERBB3(2), ERBB4(15), EREG(1), GRB2(1), GSK3B(1), HBEGF(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK9(1), NCK2(2), NRAS(1), NRG1(4), NRG2(3), NRG3(5), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG1(6), PLCG2(6), PRKCA(2), PRKCG(5), PTK2(2), RAF1(3), SHC2(2), SHC3(2), SOS1(3), SOS2(4), STAT5A(1), STAT5B(1), TGFA(2)	14361165	188	64	185	71	102	12	11	41	21	1	0.0500	1.000	1.000
351	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(14), COL4A2(8), COL4A3(13), COL4A4(22), COL4A5(20), COL4A6(6), F10(3), F11(3), F2(2), F2R(1), F5(9), F8(19), F9(2), FGA(8), FGB(5), FGG(3), KLKB1(5), PROC(2), PROS1(7), SERPINC1(2), SERPING1(3)	6333672	157	64	155	42	115	13	5	16	8	0	0.0558	1.000	1.000
352	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(1), CASP3(1), CD244(2), CD48(2), CHP(1), FAS(1), FASLG(4), FCGR3A(1), FCGR3B(1), FYN(1), GRB2(1), GZMB(1), HLA-B(1), HLA-G(1), ICAM2(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNAR1(1), IFNAR2(5), IFNB1(2), IFNG(1), IFNGR1(1), IFNGR2(2), ITGAL(6), ITGB2(2), KIR2DL1(5), KIR2DL3(2), KIR2DL4(1), KIR3DL1(4), KLRC1(2), KLRC3(4), KLRD1(1), KLRK1(1), LAT(1), LCK(1), LCP2(4), MAP2K1(3), MAP2K2(2), MAPK1(1), NCR2(1), NCR3(1), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NRAS(1), PAK1(2), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG1(6), PLCG2(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(5), PTK2B(4), PTPN11(2), PTPN6(2), RAF1(3), SHC2(2), SHC3(2), SOS1(3), SOS2(4), SYK(5), TNFRSF10A(3), TNFSF10(3), ULBP1(2), ULBP3(2), VAV1(5), VAV3(1)	15654675	211	63	209	76	122	12	8	49	19	1	0.00725	1.000	1.000
353	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(3), AKT2(2), AKT3(1), BLNK(2), BTK(5), CARD11(5), CD19(4), CD22(5), CD72(2), CD79A(1), CHP(1), CHUK(1), CR2(8), FCGR2B(1), FOS(1), GSK3B(1), IKBKB(3), INPP5D(6), JUN(1), LILRB3(2), LYN(2), MALT1(1), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB1(1), NFKB2(2), NFKBIA(1), NRAS(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLCG2(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PTPN6(2), RASGRP3(3), SYK(5), VAV1(5), VAV3(1)	10532079	145	63	145	43	83	7	7	38	9	1	0.00159	1.000	1.000
354	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(1), ACVR1C(1), ACVR2A(2), ACVR2B(2), ACVRL1(3), AMHR2(5), BMP2(1), BMP5(4), BMP6(3), BMP8A(1), BMP8B(1), BMPR1A(1), BMPR2(2), CHRD(2), COMP(4), CREBBP(4), CUL1(2), DCN(7), EP300(1), FST(1), GDF5(5), GDF6(2), IFNG(1), INHBA(5), INHBB(2), INHBC(5), INHBE(1), LEFTY1(3), LEFTY2(1), LTBP1(11), MAPK1(1), NODAL(1), PITX2(1), PPP2R1A(1), PPP2R1B(1), PPP2R2B(1), RBL1(5), RBL2(2), RHOA(1), ROCK1(2), ROCK2(6), SMAD1(2), SMAD2(1), SMAD3(1), SMAD4(2), SMAD5(1), SMAD6(1), SMAD7(1), SMAD9(2), SMURF2(1), TGFB3(2), TGFBR2(2), THBS1(8), THBS2(5), THBS3(4), THBS4(2), ZFYVE16(1), ZFYVE9(2)	14108978	146	62	144	62	90	11	1	27	17	0	0.224	1.000	1.000
355	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(7), CARM1(1), CTCFL(3), DOT1L(3), EHMT1(1), EHMT2(5), EZH1(2), EZH2(4), FBXO11(1), HCFC1(4), JMJD4(1), KDM6A(1), MEN1(1), MLL(15), MLL2(15), MLL3(13), MLL4(12), MLL5(5), NSD1(4), OGT(2), PAXIP1(1), PPP1CB(1), PPP1CC(1), PRDM2(5), PRDM7(1), PRDM9(13), PRMT5(1), PRMT6(1), PRMT8(1), RBBP5(2), SATB1(2), SETD1A(8), SETD2(3), SETDB1(3), SETDB2(2), SETMAR(2), SMYD3(1), STK38(1), SUV39H2(1), SUV420H1(3), SUV420H2(1), WHSC1(5), WHSC1L1(3)	16807161	162	61	157	44	96	14	6	24	22	0	0.00295	1.000	1.000
356	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(2), ACTB(3), ACTG1(1), ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(1), ACVR1C(1), BAIAP2(3), CDC42(2), CDH1(3), CREBBP(4), CSNK2B(1), CTNNA2(3), CTNNA3(4), CTNNB1(6), CTNND1(1), EGFR(4), EP300(1), ERBB2(1), FARP2(4), FER(2), FGFR1(4), FYN(1), IGF1R(4), INSR(6), IQGAP1(2), LEF1(1), LMO7(2), MAPK1(1), MET(8), MLLT4(2), NLK(1), PARD3(4), PTPN6(2), PTPRB(17), PTPRF(7), PTPRJ(2), PTPRM(3), PVRL1(1), PVRL2(1), PVRL4(3), RHOA(1), SMAD2(1), SMAD3(1), SMAD4(2), SNAI2(2), SORBS1(3), SSX2IP(1), TCF7L1(1), TCF7L2(3), TGFBR2(2), TJP1(4), VCL(2), WAS(2), WASF1(2), WASF2(3), WASF3(4), WASL(1), YES1(4)	17062766	164	61	162	82	93	19	7	28	17	0	0.569	1.000	1.000
357	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(1), ACVRL1(3), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(2), BUB1(1), CDKL1(1), CDS1(2), CDS2(2), CLK1(1), CLK2(2), COL4A3BP(2), CSNK2B(1), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKQ(3), DGKZ(2), IMPA1(1), INPP1(1), INPP4A(3), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(1), MAP3K10(5), MOS(1), NEK1(3), NEK3(1), OCRL(1), PAK4(2), PIK3C2A(2), PIK3C2B(4), PIK3C2G(10), PIK3CA(3), PIK3CB(9), PIK3CG(8), PIM2(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCG1(6), PLCG2(6), PLK3(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCQ(2), PRKD1(1), PRKG1(2), RAF1(3), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA4(2), STK11(2)	15978473	208	61	207	76	129	8	9	41	21	0	0.00826	1.000	1.000
358	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(2), ACAT2(1), ACMSD(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), AOC2(4), AOC3(2), AOX1(5), ASMT(1), CAT(1), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(1), CYP2A6(3), CYP2A7(3), CYP2B6(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2F1(4), CYP2J2(2), CYP3A4(8), CYP3A5(5), CYP3A7(1), CYP4B1(3), CYP4F8(3), DDC(4), ECHS1(1), EHHADH(2), GCDH(3), HAAO(1), HADHA(4), KMO(1), KYNU(5), MAOA(2), MAOB(4), TPH1(2), WARS(1), WARS2(2)	7818913	139	61	137	77	104	11	4	13	7	0	0.216	1.000	1.000
359	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(6), ATM(6), BUB1(1), BUB1B(5), CCNA1(8), CCNB2(3), CCNB3(8), CCND2(1), CCND3(1), CCNE1(1), CCNE2(5), CDAN1(2), CDC14A(2), CDC25A(1), CDC7(1), CDH1(3), CDKN1A(1), CHEK1(1), CHEK2(1), DTX4(2), E2F2(1), E2F3(4), EP300(1), ESPL1(4), GSK3B(1), HDAC1(1), HDAC2(1), HDAC4(3), HDAC6(1), HDAC8(1), MAD2L2(1), MCM2(2), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MDM2(2), MPEG1(1), MPL(2), ORC1L(1), ORC4L(1), PCNA(2), PLK1(1), PRKDC(6), PTPRA(2), PTTG2(2), RB1(2), RBL1(5), SMAD4(2), TBC1D8(2)	15351643	116	60	116	57	62	8	6	28	11	1	0.633	1.000	1.000
360	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AKT1(3), AKT2(2), AKT3(1), APAF1(1), ATM(6), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(1), CASP3(1), CASP8(4), CHP(1), CHUK(1), CSF2RB(6), DFFA(1), FAS(1), FASLG(4), IKBKB(3), IL1A(1), IL1B(2), IL1R1(2), IL1RAP(1), IL3(2), IL3RA(3), IRAK1(3), IRAK2(2), IRAK3(2), IRAK4(1), NFKB1(1), NFKB2(2), NFKBIA(1), NTRK1(5), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RELA(2), TNFRSF10A(3), TNFSF10(3)	11706844	137	60	135	41	76	10	4	35	11	1	0.00349	1.000	1.000
361	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(2), AGTR2(4), ATP8A1(3), AVPR1B(1), AVPR2(1), BDKRB1(2), BDKRB2(2), BRS3(1), C3AR1(1), CCKBR(2), CCR10(1), CCR2(2), CCR3(5), CCR4(4), CCR6(1), CCR7(1), CCR8(2), CX3CR1(5), CXCR3(1), CXCR6(1), EDNRA(4), EDNRB(3), FPR1(3), FSHR(5), GALR1(2), GALR3(1), GALT(1), GHSR(3), GNRHR(1), GPR77(2), GRPR(2), LHCGR(7), MC2R(1), MC3R(1), MC5R(3), NMBR(4), NPY1R(9), NPY2R(3), NPY5R(8), NTSR1(2), NTSR2(1), OPRD1(2), OPRK1(5), OPRL1(3), OPRM1(1), OXTR(1), PPYR1(2), SSTR1(3), SSTR2(1), SSTR3(5), TACR1(3), TACR2(1), TACR3(8), TSHR(5)	7330001	148	60	147	87	98	12	5	21	12	0	0.0130	1.000	1.000
362	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT1(3), AKT2(2), AKT3(1), CDC42(2), CHP(1), KDR(8), MAP2K1(3), MAP2K2(2), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPKAPK2(2), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NOS3(6), NRAS(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCG1(6), PLCG2(6), PPP3CA(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(5), PTGS2(2), PTK2(2), PXN(1), RAF1(3), SH2D2A(1), SHC2(2), SPHK1(1), SPHK2(1), VEGFA(2)	10183806	142	58	140	44	79	5	3	39	15	1	0.00415	1.000	1.000
363	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(2), ADCY6(2), ADCY8(13), CACNA1A(7), CACNA1B(5), GNAS(5), GNB3(1), GRM4(3), ITPR3(3), KCNB1(10), PDE1A(13), PLCB2(1), PRKACA(2), PRKACB(3), PRKACG(3), PRKX(1), SCNN1A(3), SCNN1B(4), SCNN1G(8), TAS1R1(3), TAS1R2(5), TAS2R1(3), TAS2R10(1), TAS2R14(1), TAS2R16(4), TAS2R3(1), TAS2R38(5), TAS2R39(4), TAS2R4(3), TAS2R40(1), TAS2R41(2), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R5(1), TAS2R60(5), TAS2R7(2), TAS2R8(2), TAS2R9(2), TRPM5(4)	8061639	144	58	144	95	88	12	5	27	12	0	0.409	1.000	1.000
364	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(3), ALG6(1), CCKBR(2), CCR2(2), CCR3(5), CELSR1(7), CELSR2(6), CELSR3(11), CHRM2(3), CHRM3(8), CXCR3(1), EDNRA(4), EMR2(1), EMR3(2), F2R(1), FSHR(5), GHRHR(1), GNRHR(1), GPR116(7), GPR133(1), GPR143(2), GPR18(3), GPR61(2), GPR77(2), GPR84(4), GRM1(4), GRPR(2), HRH4(3), LGR6(5), LPHN2(9), LPHN3(5), LTB4R2(1), NTSR1(2), OR2M4(4), OR8G2(2), P2RY13(2), PTGFR(1), SMO(3), SSTR2(1), TSHR(5)	9474733	134	56	134	90	81	8	9	23	13	0	0.548	1.000	1.000
365	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1D1(7), ARSE(1), CARM1(1), CYP11B1(4), CYP11B2(2), CYP19A1(3), HEMK1(2), HSD11B1(2), HSD17B12(1), HSD17B2(3), HSD3B1(3), HSD3B2(3), LCMT1(2), METTL2B(2), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), SRD5A1(1), SRD5A2(3), STS(1), SULT1E1(2), SULT2A1(1), SULT2B1(3), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5), WBSCR22(1)	6832339	119	56	117	53	80	11	6	11	11	0	0.0639	1.000	1.000
366	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACADM(1), ACOX1(5), ACOX2(1), ACOX3(3), ACSL1(1), ACSL5(5), ACSL6(3), ADIPOQ(1), APOA5(1), AQP7(1), CPT1A(3), CPT1B(4), CPT1C(7), CYP27A1(2), CYP4A11(5), CYP4A22(4), CYP7A1(1), DBI(1), EHHADH(2), FABP1(1), FABP2(3), FADS2(2), GK(1), HMGCS2(5), LPL(1), ME1(8), MMP1(4), NR1H3(2), OLR1(1), PCK1(3), PCK2(1), PDPK1(1), PPARA(3), PPARG(4), RXRG(2), SCD(1), SLC27A2(2), SLC27A4(2), SLC27A5(2), SLC27A6(6), SORBS1(3), UBC(1), UCP1(2)	9180486	112	56	109	55	72	11	5	20	4	0	0.329	1.000	1.000
367	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CLK2(2), CLK3(2), COL2A1(9), CPSF1(2), CPSF2(2), CPSF3(1), CSTF1(1), CSTF2(1), CSTF2T(1), CSTF3(1), DDIT3(1), DDX1(2), DDX20(4), DHX16(2), DHX38(2), DHX8(4), DHX9(4), DICER1(1), DNAJC8(1), LOC440563(4), LSM2(1), NCBP1(1), NONO(5), NXF1(3), POLR2A(4), PRPF18(2), PRPF3(2), PRPF4(1), PRPF4B(2), PRPF8(3), PSKH1(1), PTBP2(3), RBM5(2), RNGTT(1), SF3A1(3), SF3A2(2), SF3A3(1), SF3B1(4), SF3B2(4), SF4(3), SFRS14(5), SFRS5(1), SFRS8(2), SFRS9(1), SNRPB(1), SNRPE(1), SNRPN(2), SPOP(1), SRPK1(3), SRRM1(2), TXNL4A(1), XRN2(2)	15146013	118	56	116	47	61	11	9	19	18	0	0.431	1.000	1.000
368	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(2), ACPP(3), ALPI(4), ALPL(1), ALPP(2), ALPPL2(1), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(1), CYP2A6(3), CYP2A7(3), CYP2B6(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2F1(4), CYP2J2(2), CYP3A4(8), CYP3A5(5), CYP3A7(1), CYP4B1(3), CYP4F8(3), PON1(3)	4146393	103	55	101	50	78	9	3	8	5	0	0.0242	1.000	1.000
369	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(1), IMPA2(1), INPP1(1), INPP4A(3), INPP4B(1), INPP5A(1), INPP5B(1), INPPL1(5), ITPK1(1), ITPKB(1), MINPP1(1), OCRL(1), PI4KA(2), PI4KB(1), PIK3C3(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1A(1), PIP5K1B(4), PIP5K1C(2), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCD4(2), PLCE1(10), PLCG1(6), PLCG2(6), PLCZ1(5), SYNJ1(7), SYNJ2(2)	10381442	135	54	134	53	79	6	7	31	12	0	0.0392	1.000	1.000
370	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	CPEB1(2), EGFR(4), ERBB2(1), ERBB4(15), ETS1(1), ETS2(2), ETV6(3), ETV7(2), FMN2(16), GRB2(1), MAP2K1(3), MAPK1(1), NOTCH1(1), NOTCH2(10), NOTCH3(6), NOTCH4(14), PIWIL1(3), PIWIL2(3), PIWIL3(2), PIWIL4(1), RAF1(3), SOS1(3), SOS2(4), SPIRE1(1), SPIRE2(1)	7236391	103	54	100	46	61	5	4	24	9	0	0.506	1.000	1.000
371	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(4), CALR(1), CD4(5), CD8A(1), CIITA(5), CTSL1(1), CTSS(1), HLA-B(1), HLA-DMB(4), HLA-DOB(1), HLA-DPA1(1), HLA-DQA1(2), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), KIR2DL1(5), KIR2DL3(2), KIR2DL4(1), KIR2DS4(2), KIR3DL1(4), KIR3DL3(2), KLRC1(2), KLRC3(4), KLRC4(2), KLRD1(1), LGMN(2), NFYB(2), NFYC(1), PDIA3(2), RFX5(1), RFXANK(1), RFXAP(1), TAP2(5)	6519683	94	54	94	46	50	8	5	19	12	0	0.358	1.000	1.000
372	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(2), CHUK(1), DAXX(1), ELK1(1), FOS(1), GRB2(1), IKBKB(3), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAP3K1(1), MAP3K10(5), MAP3K11(1), MAP3K12(1), MAP3K13(4), MAP3K2(3), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K9(5), MAP4K1(3), MAP4K2(2), MAP4K3(2), MAP4K4(1), MAP4K5(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK4(5), MAPK6(2), MAPK7(1), MAPK9(1), MAPKAPK2(2), MAPKAPK5(1), MEF2A(1), MEF2D(1), MKNK1(2), NFKB1(1), NFKBIA(1), PAK1(2), PAK2(5), RAF1(3), RELA(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA4(2), RPS6KA5(1), TGFB3(2)	13167371	115	54	113	70	55	12	7	27	14	0	0.952	1.000	1.000
373	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AGT(3), AKT1(3), CALM2(1), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(4), CSNK1A1(1), EDN1(3), ELSPBP1(2), F2(2), GSK3B(1), HAND1(1), HAND2(1), IGF1(5), MAP2K1(3), MAPK1(1), MAPK14(2), MYH2(17), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NPPA(1), PIK3CA(3), PIK3R1(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RAF1(3), SYT1(8)	7224845	104	53	100	40	66	6	4	18	9	1	0.0684	1.000	1.000
374	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(2), AKT3(1), BCR(2), BLNK(2), BTK(5), CD19(4), CD22(5), CR2(8), CSK(1), DAG1(1), FLOT1(1), GRB2(1), GSK3B(1), INPP5D(6), ITPR1(10), ITPR2(3), ITPR3(3), LYN(2), MAP4K1(3), MAPK1(1), NFATC1(5), NFATC2(2), NR0B2(1), PIK3CA(3), PIK3CD(3), PIK3R1(3), PLCG2(6), PPP1R13B(3), PPP3CA(4), PPP3CB(3), PPP3CC(1), PTPRC(16), RAF1(3), SOS1(3), SOS2(4), SYK(5), VAV1(5)	10503895	135	53	134	41	84	5	11	21	13	1	0.000659	1.000	1.000
375	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(3), AKT2(2), AKT3(1), BCR(2), BTK(5), CD19(4), DAPP1(1), FLOT1(1), ITPR1(10), ITPR2(3), ITPR3(3), LYN(2), NR0B2(1), PIK3CA(3), PITX2(1), PLCG2(6), PPP1R13B(3), PREX1(4), PTPRC(16), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SAG(3), SYK(5), TEC(4), VAV1(5)	7632318	95	53	92	39	60	4	8	15	8	0	0.0399	1.000	1.000
376	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(3), AKT2(2), AKT3(1), CDC42(2), CREB5(2), ERBB4(15), F2RL2(2), GRB2(1), GSK3B(1), IGF1(5), IGFBP1(1), INPPL1(5), IRS1(1), IRS4(3), MET(8), NOLC1(1), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PARD3(4), PIK3CA(3), PIK3CD(3), PPP1R13B(3), PREX1(4), PTK2(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SLC2A4(3), SOS1(3), SOS2(4), TSC1(1), TSC2(3), YWHAB(1), YWHAQ(1)	10797560	118	53	117	59	62	9	8	31	8	0	0.604	1.000	1.000
377	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(3), CABIN1(3), CALM2(1), CAMK2B(2), CAMK4(2), CD69(2), CDKN1A(1), CNR1(1), CREBBP(4), CSNK2B(1), EGR2(2), EP300(1), FCER1A(4), FCGR3A(1), FOS(1), GRLF1(2), GSK3B(1), ICOS(1), IFNA1(1), IFNB1(2), IFNG(1), IL10(1), IL1B(2), IL2RA(1), IL3(2), ITK(2), KPNA5(1), MAP2K7(1), MAPK14(2), MAPK9(1), MEF2A(1), MEF2D(1), MYF5(4), NCK2(2), NFAT5(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB2(2), NUP214(4), OPRD1(2), P2RX7(1), PAK1(2), PIN1(1), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTPRC(16), RELA(2), TRPV6(7), VAV1(5), VAV3(1)	12951056	120	52	116	53	73	4	8	24	11	0	0.231	1.000	1.000
378	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(1), ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), AKR1A1(1), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(3), ALDH9A1(1), ALDOB(2), ALDOC(2), DLAT(1), ENO1(1), ENO2(1), ENO3(1), FBP1(1), FBP2(1), G6PC2(2), GCK(5), GPI(1), HK1(2), HK2(4), HK3(3), LDHA(1), LDHAL6A(4), LDHAL6B(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(6), PFKL(2), PFKM(1), PGAM2(1), PGK1(3), PGK2(10), PGM1(3), PKLR(2), PKM2(1)	8275988	108	52	105	42	72	10	5	15	6	0	0.0105	1.000	1.000
379	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(4), CANT1(1), DPYD(17), DPYS(12), ENTPD1(2), ENTPD3(2), ENTPD4(1), ENTPD6(1), ENTPD8(1), NME7(1), NT5C1A(1), NT5C1B(6), NT5C2(2), NT5E(1), POLA1(1), POLA2(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLR3B(7), POLR3H(1), PRIM1(2), PRIM2(5), RRM1(1), RRM2(2), RRM2B(2), TK2(1), TXNRD1(1), TYMS(1), UPB1(2), UPP2(1), UPRT(1)	11538138	108	52	105	62	62	12	9	16	9	0	0.748	1.000	1.000
380	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ABP1(2), ACAT2(1), ACMSD(1), AFMID(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(2), AOX1(5), ASMT(1), CARM1(1), CAT(1), CYP1A1(2), CYP1A2(5), CYP1B1(1), DDC(4), ECHS1(1), EHHADH(2), GCDH(3), HAAO(1), HADHA(4), HEMK1(2), HSD17B10(2), HSD17B4(4), INMT(2), KMO(1), KYNU(5), LCMT1(2), LNX1(3), MAOA(2), MAOB(4), METTL2B(2), METTL6(1), NFX1(3), OGDH(4), OGDHL(10), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), TPH1(2), TPH2(1), WARS(1), WARS2(2), WBSCR22(1)	8610665	109	52	108	60	67	8	8	19	7	0	0.560	1.000	1.000
381	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP5(4), BMP6(3), BMP8A(1), BMP8B(1), CSNK1A1(1), CSNK1A1L(1), CSNK1E(1), CSNK1G1(2), CSNK1G2(1), CSNK1G3(2), FBXW11(1), GLI1(6), GLI2(8), GLI3(7), GSK3B(1), HHIP(6), LRP2(14), PRKACA(2), PRKACB(3), PRKACG(3), PRKX(1), PTCH1(3), PTCH2(5), SHH(2), SMO(3), STK36(5), SUFU(1), WNT1(1), WNT10A(1), WNT10B(2), WNT11(1), WNT2(1), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(5), WNT7B(1), WNT8A(3), WNT8B(1), WNT9A(2), WNT9B(1), ZIC2(1)	8563703	116	52	112	51	76	8	4	14	14	0	0.0897	1.000	1.000
382	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(3), AKT2(2), AKT3(1), DAG1(1), DRD2(7), EGFR(4), EPHB2(8), GRB2(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), KCNJ3(5), KCNJ5(3), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(9), PITX2(1), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), RAF1(3), SOS1(3), SOS2(4), STAT3(6)	8101587	119	52	117	46	67	10	9	23	10	0	0.0256	1.000	1.000
383	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(3), AGTR1(2), AGTR2(4), CMA1(1), COL4A1(14), COL4A2(8), COL4A3(13), COL4A4(22), COL4A5(20), COL4A6(6), REN(3)	3602325	99	51	97	25	79	5	2	8	5	0	0.260	1.000	1.000
384	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADM(1), ACADSB(2), ACAT2(1), ACOX1(5), ACOX3(3), ACSL1(1), ACSL5(5), ACSL6(3), ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), CPT1A(3), CPT1B(4), CPT1C(7), CYP4A11(5), CYP4A22(4), DCI(1), ECHS1(1), EHHADH(2), GCDH(3), HADHA(4), HSD17B10(2), HSD17B4(4), PECI(1)	7007664	97	51	95	41	61	12	7	11	6	0	0.121	1.000	1.000
385	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(2), ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(4), AOC3(2), AOX1(5), CARM1(1), COMT(1), DBH(5), DCT(1), DDC(4), ESCO1(1), GOT1(3), GOT2(1), HEMK1(2), HGD(4), HPD(2), LCMT1(2), MAOA(2), MAOB(4), METTL2B(2), METTL6(1), MYST3(3), MYST4(2), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TAT(4), TH(4), TPO(12), TYR(4), TYRP1(3), WBSCR22(1)	8467716	121	51	119	72	81	12	7	16	5	0	0.709	1.000	1.000
386	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), AGK(1), AGPAT3(4), AGPAT4(1), AGPAT6(1), AKR1A1(1), AKR1B1(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), CEL(5), DGAT2(1), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKI(11), DGKQ(3), DGKZ(2), GK(1), GLB1(2), GPAM(1), LCT(6), LIPC(3), LIPF(5), LIPG(2), LPL(1), MGLL(1), PNLIP(1), PNLIPRP1(2), PNPLA3(1), PPAP2C(1)	8222732	110	51	106	51	69	13	5	16	7	0	0.129	1.000	1.000
387	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), CREBBP(4), CTBP2(1), DLL3(2), DLL4(2), DTX1(3), DTX3(1), DTX3L(3), DTX4(2), DVL3(4), EP300(1), HDAC1(1), HDAC2(1), HES1(2), JAG1(2), JAG2(5), MAML1(1), MAML3(1), MFNG(2), NCOR2(8), NOTCH1(1), NOTCH2(10), NOTCH3(6), NOTCH4(14), NUMB(2), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(1), RBPJL(1), SNW1(1)	9746299	89	51	89	44	50	7	4	21	7	0	0.618	1.000	1.000
388	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(3), ACSL1(1), ACSL5(5), ACSL6(3), ADIPOQ(1), AGRP(1), AKT1(3), AKT2(2), AKT3(1), CHUK(1), CPT1A(3), CPT1B(4), CPT1C(7), G6PC2(2), IKBKB(3), IRS1(1), IRS4(3), JAK1(2), JAK2(2), JAK3(1), LEP(1), LEPR(4), MAPK10(2), MAPK9(1), NFKB1(1), NFKB2(2), NFKBIA(1), NPY(3), PCK1(3), PCK2(1), PPARA(3), PPARGC1A(2), PRKAA2(6), PRKAB1(1), PRKAG1(1), PRKAG2(3), PRKAG3(2), PRKCQ(2), PTPN11(2), RELA(2), RXRG(2), SLC2A1(3), SLC2A4(3), SOCS3(1), STAT3(6), STK11(2), TYK2(1)	11804714	110	51	110	64	52	13	8	22	15	0	0.832	1.000	1.000
389	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(3), BDKRB2(2), CALM2(1), CHRNA1(1), FLT1(8), FLT4(3), KDR(8), NOS3(6), PDE2A(3), PDE3A(3), PDE3B(3), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKG1(2), PRKG2(4), RYR2(30), SLC7A1(1), SYT1(8)	5809471	96	51	91	42	69	4	3	9	11	0	0.0652	1.000	1.000
390	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(6), AXIN1(3), CCND2(1), CCND3(1), CSNK1E(1), CTNNB1(6), DVL3(4), FZD1(2), FZD2(2), FZD8(3), FZD9(1), GSK3B(1), JUN(1), LDLR(3), MAPK10(2), MAPK9(1), PAFAH1B1(2), PLAU(1), PPP2R5E(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCI(3), PRKCQ(2), PRKD1(1), RHOA(1), SFRP4(3), WNT1(1), WNT10A(1), WNT10B(2), WNT11(1), WNT2(1), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(5), WNT7B(1)	8408026	86	50	85	33	49	10	2	9	16	0	0.0355	1.000	1.000
391	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(1), ATM(6), ATR(6), BAI1(4), CASP3(1), CASP8(4), CCNB2(3), CCNB3(8), CCND2(1), CCND3(1), CCNE1(1), CCNE2(5), CDK6(1), CDKN1A(1), CHEK1(1), CHEK2(1), DDB2(1), FAS(1), GTSE1(1), IGF1(5), LRDD(2), MDM2(2), MDM4(1), PERP(1), RFWD2(1), RPRM(1), RRM2(2), RRM2B(2), SERPINB5(1), SERPINE1(1), SESN2(1), STEAP3(1), THBS1(8), TP53I3(2), TP73(1), TSC2(3)	8839808	83	49	83	49	43	5	6	24	5	0	0.923	1.000	1.000
392	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(4), ADAM17(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), CASP3(1), CDC42(2), CHUK(1), CSK(1), EGFR(4), F11R(3), HBEGF(1), IGSF5(3), IKBKB(3), JAM2(4), JAM3(2), JUN(1), LYN(2), MAP2K4(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(1), MET(8), NFKB1(1), NFKB2(2), NFKBIA(1), NOD1(1), PAK1(2), PLCG1(6), PLCG2(6), PTPN11(2), PTPRZ1(5), RELA(2), TCIRG1(2), TJP1(4)	9965506	101	49	101	52	51	13	6	25	6	0	0.603	1.000	1.000
393	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN2A(27), GRIN2B(16), GRIN2C(2), GRIN2D(1), NOS1(17), PPP3CA(4), PPP3CB(3), PPP3CC(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), SYT1(8)	3622923	93	49	91	35	69	8	1	7	8	0	0.00337	1.000	1.000
394	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(16), B3GALT4(2), DGKI(11), IL6ST(5), MRPL19(1), PIGK(1), RPL10(1), RPL11(1), RPL15(1), RPL18(1), RPL21(1), RPL22(1), RPL27(2), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL38(1), RPL3L(1), RPL4(1), RPL5(3), RPS11(1), RPS16(1), RPS23(1), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA6(7), RPS7(3), RPS8(1), SLC36A2(3), TBC1D10C(1), TSPAN9(2), UBC(1)	7324041	83	49	80	43	45	5	8	16	9	0	0.535	1.000	1.000
395	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(2), BTK(5), CAD(4), CASP10(1), CASP3(1), CASP8(4), CASP8AP2(3), CSNK1A1(1), DAXX(1), DEDD(1), DFFA(1), EGFR(4), EPHB2(8), FAF1(4), FAIM2(2), HSPB1(1), IL1A(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K5(5), MAPK1(1), MAPK10(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), MET(8), NFAT5(2), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), NR0B2(1), PTPN13(4), ROCK1(2), SMPD1(2), TNFRSF6B(2), TPX2(2), TUFM(1)	10232668	90	49	89	44	44	11	8	16	11	0	0.528	1.000	1.000
396	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	AKT1(3), APC(6), DAG1(1), DLG4(1), EPHB2(8), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(3), ITPR3(3), KCNJ3(5), KCNJ5(3), KCNJ9(1), MAPK1(1), PITX2(1), PTX3(1), RYR1(27)	6410291	76	49	76	41	56	7	4	2	7	0	0.183	1.000	1.000
397	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CSK(1), DAG1(1), EPHB2(8), FBXW7(4), GRAP2(1), GRB2(1), ITK(2), ITPKB(1), LAT(1), LCK(1), LCP2(4), MAPK1(1), NFAT5(2), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PLCG1(6), PTPRC(16), RAF1(3), RASGRP2(3), RASGRP3(3), RASGRP4(4), SOS1(3), SOS2(4), VAV1(5)	7894086	107	49	106	42	64	8	10	19	6	0	0.0888	1.000	1.000
398	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(6), CCNA1(8), CCND2(1), CCND3(1), CCNE1(1), CCNE2(5), CDC25A(1), CDKN1A(1), CREB3L3(3), CREB3L4(3), E2F2(1), E2F3(4), GBA2(1), MCM2(2), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MDM2(2), MNAT1(2), MYT1(7), ORC1L(1), ORC4L(1), PCNA(2), POLA2(2), POLE(4), POLE2(1), PRIM1(2), RB1(2), RBL1(5), RPA1(2), RPA2(1), RPA3(1), TFDP2(2), TNXB(42)	10972956	122	48	121	51	65	9	3	34	10	1	0.235	1.000	1.000
399	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(1), ALAS1(1), ALAS2(3), COX15(1), CP(3), EPRS(5), FTMT(2), GUSB(3), HCCS(2), HMOX1(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5)	5724982	87	48	86	36	57	7	3	10	10	0	0.144	1.000	1.000
400	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(3), AKT2(2), AKT3(1), FIGF(2), HIF1A(3), IGF1(5), MAPK1(1), PDPK1(1), PIK3CA(3), PIK3CB(9), PIK3CD(3), PIK3CG(8), PIK3R1(3), PIK3R2(3), PIK3R5(7), PRKAA2(6), RICTOR(2), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), RPS6KA6(7), STK11(2), TSC1(1), TSC2(3), ULK1(1), ULK2(3), ULK3(1), VEGFA(2), VEGFB(1), VEGFC(6)	7279293	96	48	95	33	49	3	4	28	11	1	0.0703	1.000	1.000
401	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(1), INPP4A(3), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(1), OCRL(1), PIK3C2A(2), PIK3C2B(4), PIK3C2G(10), PIK3CA(3), PIK3CB(9), PIK3CG(8), PLCB1(16), PLCB2(1), PLCB3(2), PLCB4(19), PLCG1(6), PLCG2(6)	6357232	100	47	99	36	61	4	6	21	8	0	0.0306	1.000	1.000
402	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	AKT1(3), AKT2(2), AKT3(1), ANGPTL2(1), ARHGEF11(4), BTK(5), CDC42(2), CFL1(1), GDI2(1), INPPL1(5), ITPR1(10), ITPR2(3), ITPR3(3), MYLK(9), MYLK2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), PIK3CA(3), PIK3CD(3), PIK3CG(8), PIK3R1(3), PITX2(1), PPP1R13B(3), ROCK1(2), ROCK2(6), SAG(3), WASF1(2), WASL(1)	9824477	110	47	109	42	67	10	4	21	7	1	0.0250	1.000	1.000
403	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(2), ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(4), AOC3(2), AOX1(5), COMT(1), DBH(5), DCT(1), DDC(4), GOT1(3), GOT2(1), HGD(4), HPD(2), MAOA(2), MAOB(4), TAT(4), TH(4), TPO(12), TYR(4)	4506438	95	47	93	52	71	8	4	9	3	0	0.270	1.000	1.000
404	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), AKR1A1(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(2), ALDOC(2), DLAT(1), ENO1(1), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GCK(5), GPI(1), HK1(2), HK2(4), HK3(3), LDHA(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(6), PFKM(1), PGK1(3), PGM1(3), PKLR(2), PKM2(1)	6949287	85	46	83	34	55	10	4	11	5	0	0.0267	1.000	1.000
405	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), AKR1A1(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), ALDOB(2), ALDOC(2), DLAT(1), ENO1(1), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GCK(5), GPI(1), HK1(2), HK2(4), HK3(3), LDHA(1), LDHB(2), LDHC(2), PDHA1(1), PDHA2(6), PFKM(1), PGK1(3), PGM1(3), PKLR(2), PKM2(1)	6949287	85	46	83	34	55	10	4	11	5	0	0.0267	1.000	1.000
406	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), AKT1(3), ANGPTL2(1), CDC42(2), CFL1(1), FLNA(6), FLNC(15), FSCN1(1), FSCN3(3), GDI2(1), MYH2(17), MYLK(9), MYLK2(2), PAK1(2), PAK2(5), PAK3(3), PAK4(2), PAK6(1), PAK7(10), ROCK1(2), ROCK2(6), VASP(1), WASF1(2), WASL(1)	6781914	97	46	97	53	59	9	3	19	7	0	0.414	1.000	1.000
407	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(1), CAMK1(2), CAMK1G(1), ELK1(1), FPR1(3), GNA15(3), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(1), MAP3K1(1), MAPK1(1), MAPK14(2), NCF2(2), NFATC1(5), NFATC2(2), NFATC3(4), NFATC4(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(10), PLCB1(16), PPP3CA(4), PPP3CB(3), PPP3CC(1), RAF1(3), RELA(2), SYT1(8)	5367798	90	45	87	30	59	5	5	13	8	0	0.0251	1.000	1.000
408	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	AKR1B1(1), GUSB(3), UGDH(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2A1(5), UGT2A3(8), UGT2B10(15), UGT2B11(3), UGT2B28(5), UGT2B4(7), UGT2B7(5), XYLB(4)	3602005	74	45	73	31	54	4	3	7	6	0	0.133	1.000	1.000
409	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(2), ALOX12B(4), ALOX15B(2), CYP2B6(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2J2(2), CYP4A11(5), CYP4A22(4), CYP4F2(6), CYP4F3(4), EPHX2(1), GGT1(2), GPX1(1), GPX5(2), GPX6(3), LTA4H(2), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PTGIS(2), PTGS1(7), PTGS2(2), TBXAS1(3)	5497896	107	45	106	60	82	7	2	9	7	0	0.138	1.000	1.000
410	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(6), CCND2(1), DAZL(3), DMC1(2), ESR2(3), FSHR(5), INHA(1), LHCGR(7), MLH1(1), MSH5(4), NCOR1(7), NR5A1(1), NRIP1(2), PGR(4), PRLR(9), PTGER2(2), SMPD1(2), VDR(1), ZP2(4)	4886350	65	45	63	31	41	7	1	7	9	0	0.472	1.000	1.000
411	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(4), CANT1(1), DPYD(17), DPYS(12), ENTPD1(2), NT5E(1), POLD1(2), POLE(4), POLG(4), POLL(1), POLQ(7), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLRMT(1), RRM1(1), RRM2(2), TK2(1), TXNRD1(1), TYMS(1), UPB1(2)	8162541	77	45	74	34	47	4	6	13	7	0	0.259	1.000	1.000
412	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH6(3), ADH7(5), AGPAT3(4), AGPAT4(1), AKR1A1(1), AKR1B1(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), CEL(5), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKQ(3), DGKZ(2), GK(1), GLB1(2), LCT(6), LIPC(3), LIPF(5), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(2), PPAP2C(1)	6876910	92	44	90	43	61	13	4	12	2	0	0.139	1.000	1.000
413	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), AKR1B10(3), B4GALT1(1), B4GALT2(1), G6PC2(2), GAA(1), GALK2(1), GALT(1), GANC(4), GCK(5), GLB1(2), HK1(2), HK2(4), HK3(3), HSD3B7(2), LALBA(2), LCT(6), MGAM(39), PFKL(2), PFKM(1), PGM1(3), RDH11(1), RDH12(1), RDH13(1)	5487034	89	44	89	53	61	3	3	15	7	0	0.547	1.000	1.000
414	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(2), ACADM(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(2), CNDP1(3), DPYD(17), DPYS(12), ECHS1(1), EHHADH(2), GAD1(5), GAD2(4), HADHA(4), SMS(4), UPB1(2)	3852227	71	44	69	31	38	10	4	13	6	0	0.222	1.000	1.000
415	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(6), ACTB(3), ACTG1(1), ARHGEF2(6), CD14(1), CDC42(2), CDH1(3), CLDN1(3), CTNNB1(6), FYN(1), HCLS1(1), ITGB1(1), LY96(3), NCK2(2), NCL(3), PRKCA(2), RHOA(1), ROCK1(2), ROCK2(6), TLR4(6), TLR5(3), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA4A(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB3(1), TUBB4(2), TUBB4Q(3), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1)	7457780	87	44	87	34	49	13	1	11	13	0	0.0715	1.000	1.000
416	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(6), ACTB(3), ACTG1(1), ARHGEF2(6), CD14(1), CDC42(2), CDH1(3), CLDN1(3), CTNNB1(6), FYN(1), HCLS1(1), ITGB1(1), LY96(3), NCK2(2), NCL(3), PRKCA(2), RHOA(1), ROCK1(2), ROCK2(6), TLR4(6), TLR5(3), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA4A(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB3(1), TUBB4(2), TUBB4Q(3), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1)	7457780	87	44	87	34	49	13	1	11	13	0	0.0715	1.000	1.000
417	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(2), AGMAT(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), AOC2(4), AOC3(2), ARG1(1), ASL(2), CKM(1), CKMT2(2), CPS1(5), DAO(3), GAMT(1), GATM(2), GOT1(3), GOT2(1), MAOA(2), MAOB(4), NOS1(17), NOS3(6), ODC1(3), OTC(1), P4HA1(3), P4HA2(2), P4HA3(5), P4HB(1), RARS(1), SMS(4)	6281146	86	43	85	37	55	8	7	8	8	0	0.0524	1.000	1.000
418	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(2), ACADM(1), ACADSB(2), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), AOC2(4), AOC3(2), CNDP1(3), DPYD(17), DPYS(12), ECHS1(1), EHHADH(2), GAD1(5), GAD2(4), HADHA(4), SMS(4), UPB1(2)	4144329	73	43	71	32	39	11	3	14	6	0	0.239	1.000	1.000
419	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(1), B4GALT2(1), FBP2(1), GAA(1), GALK2(1), GALT(1), GANAB(2), GCK(5), GLB1(2), HK1(2), HK2(4), HK3(3), LALBA(2), LCT(6), MGAM(39), PFKM(1), PGM1(3)	4629163	76	43	76	46	52	3	3	12	6	0	0.578	1.000	1.000
420	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(11), GABBR1(1), GPRC5A(1), GPRC5B(2), GPRC5C(4), GPRC5D(2), GRM1(4), GRM2(1), GRM3(11), GRM4(3), GRM5(3), GRM7(6), GRM8(17)	2978506	66	43	65	43	50	6	3	6	1	0	0.234	1.000	1.000
421	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(3), AASS(2), ACAT2(1), AKR1B10(3), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(1), EHHADH(2), EHMT1(1), EHMT2(5), GCDH(3), HADHA(4), HSD17B10(2), HSD17B4(4), HSD3B7(2), NSD1(4), OGDH(4), OGDHL(10), PIPOX(2), PLOD1(2), PLOD2(1), PLOD3(2), RDH11(1), RDH12(1), RDH13(1), SETD1A(8), SETDB1(3), SHMT1(1), SUV39H2(1)	8228095	86	43	85	35	49	7	6	18	6	0	0.156	1.000	1.000
422	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(3), ATF2(2), CDC42(2), DUSP8(2), GCK(5), IL1R1(2), JUN(1), MAP2K4(1), MAP2K7(1), MAP3K1(1), MAP3K10(5), MAP3K11(1), MAP3K12(1), MAP3K13(4), MAP3K2(3), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K9(5), MAPK10(2), MAPK7(1), MAPK9(1), MYEF2(3), NFATC3(4), PAPPA(9), TRAF6(1)	7047232	72	43	72	41	44	5	3	10	10	0	0.890	1.000	1.000
423	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), CYP1A2(5), CYP2C18(7), CYP2C19(6), CYP2C8(7), CYP2C9(10), CYP2E1(5), CYP2J2(2), CYP3A4(8), CYP3A43(7), CYP3A5(5), CYP3A7(1), HSD3B7(2), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), RDH11(1), RDH12(1), RDH13(1)	3402576	82	42	80	36	63	6	2	5	6	0	0.0243	1.000	1.000
424	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(3), AKT2(2), AKT3(1), BRD4(5), CBL(1), CDC42(2), F2RL2(2), FLOT1(1), GRB2(1), GSK3B(1), IGFBP1(1), INPPL1(5), IRS1(1), IRS4(3), LNPEP(5), MAPK1(1), PARD3(4), PIK3CA(3), PIK3CD(3), PIK3R1(3), PPYR1(2), RAF1(3), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SLC2A4(3), SORBS1(3), SOS1(3), SOS2(4), YWHAB(1), YWHAQ(1)	8298482	75	42	75	31	33	10	6	20	5	1	0.362	1.000	1.000
425	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(3), F13B(7), F2(2), F5(9), F7(1), F8(19), F9(2), FGA(8), FGB(5), FGG(3), LPA(10), PLAU(1), PLG(4), SERPINB2(4), SERPINE1(1), VWF(11)	5009419	93	41	93	37	64	6	4	11	7	1	0.151	1.000	1.000
426	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(2), ACY3(1), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(3), ALDH9A1(1), AMDHD1(3), AOC2(4), AOC3(2), CARM1(1), CNDP1(3), DDC(4), FTCD(1), HAL(6), HARS(2), HARS2(2), HDC(6), HEMK1(2), LCMT1(2), MAOA(2), MAOB(4), METTL2B(2), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), PRPS1(2), PRPS2(1), UROC1(2), WBSCR22(1)	5628574	71	41	71	45	43	8	4	9	7	0	0.673	1.000	1.000
427	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(1), ALPP(2), ALPPL2(1), ASCC3(2), ATP13A2(3), DDX18(2), DDX23(3), DDX4(2), DDX41(3), DDX51(2), DDX52(1), DDX54(1), DDX55(1), DHX58(3), ENTPD7(1), EP400(7), ERCC2(1), ERCC3(1), IFIH1(7), MOV10L1(7), NUDT5(1), RAD54B(2), RUVBL2(2), SETX(7), SKIV2L2(2), SMARCA2(2), SMARCA5(4), SPR(1)	8895297	76	41	72	31	39	8	5	15	9	0	0.237	1.000	1.000
428	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(9), C5(4), C6(21), C7(11), IL1A(1), ITGA4(10), ITGAL(6), ITGB1(1), ITGB2(2), SELP(11), SELPLG(3), VCAM1(3)	3524836	82	41	79	30	58	4	3	11	6	0	0.0280	1.000	1.000
429	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(5), CPT1B(4), CREBBP(4), EHHADH(2), EP300(1), FABP1(1), HSD17B4(4), JUN(1), LPL(1), MAPK1(1), ME1(8), NCOA1(3), NCOR1(7), NCOR2(8), NFKBIA(1), NR0B2(1), NR1H3(2), NR2F1(1), NRIP1(2), PDGFA(1), PIK3CA(3), PIK3R1(3), PPARA(3), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), PTGS2(2), RB1(2), RELA(2), STAT5A(1), STAT5B(1)	9029133	87	41	86	35	50	4	7	17	7	2	0.256	1.000	1.000
430	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(6), DAG1(1), EGFR(4), GNA15(3), GNAI1(1), GNAQ(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), KCNJ3(5), KCNJ5(3), KCNJ9(1), MAPK1(1), MAPK10(2), MAPK14(2), PHKA2(3), PIK3CA(3), PIK3CD(3), PIK3R1(3), PITX2(1), PTX3(1), RAF1(3)	7340732	67	41	67	35	33	9	5	9	10	1	0.482	1.000	1.000
431	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(2), AKT3(1), ANKRD6(1), APC(6), AXIN1(3), AXIN2(1), CER1(5), CSNK1A1(1), CTNNB1(6), DACT1(3), DKK1(1), DKK2(2), DKK4(1), GSK3B(1), LRP1(7), MVP(5), NKD1(3), NKD2(3), PIN1(1), PSEN1(1), PTPRA(2), SENP2(3), TSHB(1)	5685907	63	41	62	30	32	7	3	10	11	0	0.462	1.000	1.000
432	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	AGPAT3(4), AGPAT4(1), AGPAT6(1), CDS1(2), CDS2(2), CHAT(3), CHKA(1), CHKB(1), CRLS1(1), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKI(11), DGKQ(3), DGKZ(2), ESCO1(1), ETNK1(2), GNPAT(1), GPAM(1), GPD1(2), GPD1L(1), MYST3(3), MYST4(2), PCYT1A(1), PCYT1B(1), PEMT(1), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLD1(5), PLD2(1), PNPLA3(1), PPAP2C(1), SH3GLB1(1)	9297537	85	40	83	45	43	9	3	21	9	0	0.632	1.000	1.000
433	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	CRKL(1), DOCK1(2), ELK1(1), FOS(1), GRB2(1), HGF(7), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP4K1(3), MAPK1(1), MET(8), PAK1(2), PIK3CA(3), PIK3R1(3), PTK2(2), PTK2B(4), PTPN11(2), PXN(1), RAF1(3), RASA1(1), SOS1(3), STAT3(6)	6106821	65	40	63	29	35	5	4	14	6	1	0.596	1.000	1.000
434	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF2B1(3), EIF2S1(1), ELAVL1(1), FLT1(8), FLT4(3), HIF1A(3), KDR(8), NOS3(6), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), PTK2(2), PXN(1), VHL(1)	4867123	53	40	51	26	30	2	2	11	7	1	0.600	1.000	1.000
435	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BIRC3(3), CASP10(1), CASP3(1), CASP8(4), CHUK(1), DFFA(1), FAS(1), FASLG(4), GZMB(1), HELLS(1), IKBKB(3), IRF1(1), IRF2(3), IRF3(1), IRF4(3), IRF6(2), IRF7(2), JUN(1), MAP2K4(1), MAP3K1(1), MAPK10(2), MDM2(2), NFKB1(1), NFKBIA(1), PLEKHG5(2), RELA(2), TNFRSF21(1), TNFRSF25(1), TNFSF10(3), TP73(1), TRAF1(1), TRAF3(2)	8018586	56	39	56	28	29	7	5	12	3	0	0.546	1.000	1.000
436	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(4), CALM2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CDK5(1), F2(2), FYN(1), GNAI1(1), GRB2(1), JAK2(2), MAP2K1(3), MAP2K2(2), MAPK1(1), MAPK14(2), MAPT(1), MYLK(9), PLCG1(6), PRKCA(2), PTK2B(4), RAF1(3), SOS1(3), STAT3(6), STAT5A(1), SYT1(8)	5894853	74	39	71	30	40	8	5	11	10	0	0.167	1.000	1.000
437	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(2), AGXT(7), AGXT2(5), ALAS1(1), ALAS2(3), AMT(1), AOC2(4), AOC3(2), BHMT(1), CBS(1), CHDH(1), CHKA(1), CHKB(1), CPT1B(4), CTH(1), DAO(3), DMGDH(6), GAMT(1), GARS(2), GATM(2), GCAT(2), GLDC(2), MAOA(2), MAOB(4), PEMT(1), PLCB2(1), PLCG1(6), PLCG2(6), PSPH(1), SARDH(2), SARS(6), SHMT1(1), TARS(1)	5994671	84	39	84	30	52	9	3	13	7	0	0.0102	1.000	1.000
438	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(2), CYP4F2(6), CYP4F3(4), GGT1(2), LPO(5), LTA4H(2), MPO(4), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PRDX6(1), PTGIS(2), PTGS1(7), PTGS2(2), TBXAS1(3), TPO(12)	3960131	63	39	63	39	46	5	2	5	5	0	0.400	1.000	1.000
439	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(2), AKT3(1), ARHGEF11(4), CDC42(2), DLG4(1), LPA(10), MAP2K4(1), MAP3K1(1), MAP3K5(5), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PHKA2(3), PI3(1), PIK3CB(9), PLD1(5), PLD2(1), PTK2(2), RDX(1), ROCK1(2), ROCK2(6), SERPINA4(7)	6985417	75	38	75	34	34	6	7	19	9	0	0.457	1.000	1.000
440	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(2), AGXT(7), AGXT2(5), AKR1B10(3), ALAS1(1), ALAS2(3), AMT(1), AOC2(4), AOC3(2), BHMT(1), CBS(1), CHDH(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DMGDH(6), GAMT(1), GARS(2), GATM(2), GCAT(2), GLDC(2), HSD3B7(2), MAOA(2), MAOB(4), PEMT(1), PHGDH(5), PIPOX(2), PSPH(1), RDH11(1), RDH12(1), RDH13(1), SARDH(2), SARS(6), SARS2(1), SHMT1(1), TARS(1), TARS2(1)	6089485	84	37	82	30	51	9	1	14	9	0	0.0164	1.000	1.000
441	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(1), ADRBK2(1), ARRB2(1), CALM2(1), CALML3(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CLCA1(2), CLCA2(2), CLCA4(4), CNGA3(5), CNGA4(5), CNGB1(5), GNAL(2), GUCA1A(2), GUCA1B(1), PDC(3), PDE1C(10), PRKACA(2), PRKACB(3), PRKACG(3), PRKG1(2), PRKG2(4), PRKX(1)	4242942	68	37	67	34	41	6	1	10	10	0	0.330	1.000	1.000
442	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT3(4), AGPAT4(1), AGPS(1), CDS1(2), CDS2(2), CHAT(3), CHKA(1), CHKB(1), CPT1B(4), DGKA(1), DGKB(7), DGKD(2), DGKE(1), DGKG(6), DGKQ(3), DGKZ(2), ETNK1(2), GNPAT(1), GPD1(2), LGALS13(2), PAFAH1B1(2), PCYT1A(1), PCYT1B(1), PEMT(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLCB2(1), PLCG1(6), PLCG2(6), PPAP2C(1)	7109231	76	36	76	36	41	7	4	18	6	0	0.250	1.000	1.000
443	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(6), ATP4A(4), ATP5C1(1), ATP5F1(2), ATP5J(1), ATP5O(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), COX15(1), COX6B1(1), COX6C(1), COX7B(1), COX7B2(2), COX8C(1), CYC1(3), NDUFA12(1), NDUFA13(1), NDUFA9(1), NDUFB2(1), NDUFB5(1), NDUFB6(1), NDUFS3(1), NDUFV1(2), PPA1(1), PPA2(2), SDHB(1), TCIRG1(2), UQCRC1(2)	7977878	59	36	59	27	35	3	5	12	4	0	0.280	1.000	1.000
444	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	C1GALT1(1), GALNT1(1), GALNT10(5), GALNT12(2), GALNT13(7), GALNT14(5), GALNT2(1), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(5), GALNT9(2), GALNTL1(1), GALNTL2(3), GALNTL4(2), GALNTL5(6), GCNT1(3), GCNT3(4), GCNT4(1), OGT(2), ST3GAL2(1), ST6GALNAC1(2)	4428297	61	36	60	26	47	0	2	5	7	0	0.185	1.000	1.000
445	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(6), ACACB(3), ACAT2(1), ACOT12(4), ACSS1(1), ACSS2(1), AKR1B1(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), DLAT(1), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(4), LDHAL6B(1), LDHB(2), LDHC(2), MDH2(1), ME1(8), ME2(1), ME3(4), PC(7), PCK1(3), PCK2(1), PDHA1(1), PDHA2(6), PKLR(2), PKM2(1)	6670033	72	36	71	31	44	4	3	16	5	0	0.159	1.000	1.000
446	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), CARS(4), CARS2(1), DARS2(2), EPRS(5), FARS2(1), FARSA(2), FARSB(1), GARS(2), HARS(2), HARS2(2), IARS(2), IARS2(1), LARS(3), MARS(2), MARS2(1), NARS(1), NARS2(1), QARS(1), RARS(1), SARS(6), SARS2(1), TARS(1), TARS2(1), VARS(4), VARS2(3), WARS(1), WARS2(2), YARS2(1)	7793965	58	36	57	21	32	7	4	11	4	0	0.154	1.000	1.000
447	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(3), CR1(14), CR2(8), FCGR2B(1), HLA-DRA(3), HLA-DRB1(1), ITGAL(6), ITGB2(2), PTPRC(16)	2146957	54	35	53	25	36	4	3	8	3	0	0.460	1.000	1.000
448	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), BAG4(3), BIRC3(3), CASP3(1), CASP8(4), CHUK(1), DAXX(1), DFFA(1), LMNA(4), LMNB1(1), LMNB2(2), MAP2K7(1), MAP3K1(1), MAP3K5(5), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(2), PAK2(5), PRKCD(2), PRKDC(6), PSEN1(1), PSEN2(2), PTK2(2), RASA1(1), RB1(2), RELA(2), SPTAN1(2), TRAF1(1)	9862548	62	35	62	31	22	9	6	22	2	1	0.709	1.000	1.000
449	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACADM(1), ACAT2(1), ALDH1B1(2), ALDH3A1(1), ALDH6A1(2), ALDH7A1(3), ALDH9A1(1), AOX1(5), BCAT1(4), BCKDHB(1), ECHS1(1), EHHADH(2), HADHA(4), HIBADH(4), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(4), IVD(1), MCEE(2), MUT(2), OXCT1(2), OXCT2(1), PCCA(2)	6154587	55	35	54	29	28	6	5	12	4	0	0.716	1.000	1.000
450	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(1), ADCY9(5), ARF4(2), ARF5(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D2(1), ATP6V0E1(1), ATP6V1C2(2), ATP6V1G3(1), ERO1L(1), GNAS(5), PDIA4(1), PLCG1(6), PLCG2(6), PRKCA(2), SEC61A2(5), TRIM23(1)	5279898	51	35	51	30	29	1	3	12	6	0	0.735	1.000	1.000
451	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(3), ANGPTL2(1), DAG1(1), DGKA(1), ITGA9(4), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), MAP2K1(3), MAPK1(1), NR1I3(2), PAK1(2), PDE3A(3), PDE3B(3), PI3(1), PIK3C2G(10), PIK3CA(3), PIK3CD(3), PIK3R1(3), RIPK3(3), VASP(1)	6897884	65	35	63	23	41	4	5	10	4	1	0.0365	1.000	1.000
452	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(3), ATF1(3), CREB5(2), CREBBP(4), CRKL(1), DAG1(1), EGR2(2), EGR4(1), ELK1(1), FRS2(1), GNAQ(1), JUN(1), MAP1B(5), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), NTRK1(5), OPN1LW(1), PIK3C2G(10), PIK3CA(3), PIK3CD(3), PIK3R1(3), PTPN11(2), RPS6KA3(1), TH(4)	7052099	66	35	66	29	38	5	2	16	4	1	0.355	1.000	1.000
453	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(1), DAXX(1), EGF(3), EGFR(4), ETS1(1), ETS2(2), FOS(1), IKBKB(3), JUN(1), MAP2K1(3), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP2K7(1), MAP3K1(1), MAP3K5(5), MAPK1(1), MAPK13(1), MAPK14(2), NFKB1(1), NFKBIA(1), PRKCA(2), PRKCD(2), PRKCE(2), PRKCG(5), PRKCH(4), PRKCQ(2), RAF1(3), RELA(2)	6965468	61	34	59	33	31	8	3	13	6	0	0.636	1.000	1.000
454	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(2), ADC(1), AGMAT(1), ALDH18A1(3), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(2), ARG1(1), ASL(2), ASS1(2), CPS1(5), GATM(2), MAOA(2), MAOB(4), ODC1(3), OTC(1), SMS(4)	4162305	46	33	46	25	26	4	3	7	6	0	0.455	1.000	1.000
455	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(6), AXIN1(3), CREBBP(4), CTNNB1(6), EP300(1), FZD1(2), GSK3B(1), HDAC1(1), LDB1(1), LEF1(1), PITX2(1), TRRAP(15), WNT1(1)	4739000	43	33	42	20	21	2	3	9	8	0	0.647	1.000	1.000
456	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1L(1), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2F1(3), GTF2H1(1), GTF2IRD1(2), TAF1(3), TAF1L(10), TAF2(2), TAF4(1), TAF4B(1), TAF6(2), TAF6L(3), TAF7(1), TAF7L(5), TAF9(1), TAF9B(1), TBPL1(1), TBPL2(2)	5168799	44	32	44	16	22	4	3	12	3	0	0.487	1.000	1.000
457	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(4), BCAR1(1), BCR(2), CAPN1(2), CRKL(1), CSK(1), FYN(1), GRB2(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(3), MAP2K2(2), MAPK1(1), PPP1R12B(4), PTK2(2), PXN(1), RAF1(3), ROCK1(2), SOS1(3), TLN1(2), VCL(2), ZYX(2)	6640278	46	32	44	20	21	6	3	11	5	0	0.378	1.000	1.000
458	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(3), ADRA1D(1), ADRA2C(1), CHRM2(3), CHRM3(8), CHRM4(1), CHRM5(1), DRD1(1), DRD2(7), DRD5(8), HRH1(3), HTR1A(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(3), HTR4(3), HTR5A(3), HTR7(3)	3587145	53	32	52	38	33	7	2	9	2	0	0.273	1.000	1.000
459	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(5), DLG4(1), EPHB2(8), F2(2), F2RL1(3), F2RL2(2), F2RL3(2), JUN(1), MAPK1(1), MAPK7(1), MYEF2(3), PLD1(5), PLD2(1), PTK2(2), RAF1(3), RASAL1(3), TEC(4), VAV1(5)	3898198	52	32	51	25	26	5	4	14	3	0	0.533	1.000	1.000
460	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(3), CDC42(2), CREB5(2), ELK1(1), HSPB1(1), IL1R1(2), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP3K10(5), MAP3K4(5), MAP3K5(5), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPKAPK2(2), MAPKAPK5(1), MKNK1(2), MYEF2(3), NFKB1(1), TRAF6(1)	4736357	51	32	51	25	29	5	1	11	5	0	0.457	1.000	1.000
461	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADM(1), ACADSB(2), ACAT2(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH6A1(2), ALDH9A1(1), AOX1(5), BCAT1(4), BCKDHB(1), ECHS1(1), EHHADH(2), HADHA(4), HIBADH(4), IVD(1), MCEE(2), MUT(2), OXCT1(2), PCCA(2)	5155419	43	32	42	25	23	5	2	9	4	0	0.819	1.000	1.000
462	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(6), ATF2(2), AXIN1(3), BMP10(3), BMP2(1), BMP5(4), BMPR1A(1), BMPR2(2), CHRD(2), CTNNB1(6), FZD1(2), GSK3B(1), MYL2(1), NPPA(1), RFC1(2), TGFB3(2), TGFBR2(2), TGFBR3(1), WNT1(1)	5149781	45	31	44	19	26	3	2	7	7	0	0.413	1.000	1.000
463	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(3), AGTR1(2), ATF2(2), CALM2(1), EGFR(4), ELK1(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(3), MAP2K2(2), MAP2K4(1), MAP3K1(1), MAPK1(1), MEF2A(1), MEF2D(1), PAK1(2), PRKCA(2), PTK2(2), PTK2B(4), RAF1(3), SOS1(3), SYT1(8)	4703258	50	31	47	28	28	3	4	9	6	0	0.836	1.000	1.000
464	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(12), AKT1(3), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), GNAS(5), GRB2(1), MAPK1(1), MAPK14(2), PIK3CA(3), PIK3R1(3), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PRKCA(2), RPS6KA1(1), RPS6KA5(1), SOS1(3)	4054589	54	31	54	24	30	3	3	6	11	1	0.392	1.000	1.000
465	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), GNAI1(1), GNAQ(1), MAP2K1(3), MAPK1(1), NFKB1(1), PIK3C2G(10), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), PTK2(2), PTK2B(4), PXN(1), RAF1(3), RELA(2)	3919898	44	31	42	19	24	2	2	11	4	1	0.438	1.000	1.000
466	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(4), ELK1(1), GNAS(5), GRB2(1), IGF1R(4), ITGB1(1), KLK2(1), MAP2K1(3), MAP2K2(2), MAPK1(1), MKNK1(2), PDGFRA(5), PTPRR(4), RAF1(3), RPS6KA1(1), RPS6KA5(1), SOS1(3), STAT3(6)	4677040	49	31	47	31	27	6	3	9	4	0	0.891	1.000	1.000
467	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(3), CALCRL(5), CD97(2), CRHR1(1), CRHR2(1), ELTD1(5), EMR1(8), EMR2(1), GHRHR(1), GLP1R(4), GLP2R(4), GPR64(2), LPHN1(3), LPHN2(9), LPHN3(5), SCTR(2), VIPR1(1)	3760718	62	31	61	34	45	2	5	6	4	0	0.213	1.000	1.000
468	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(4), AOC3(2), DDC(4), ESCO1(1), GOT1(3), GOT2(1), HPD(2), LPO(5), MAOA(2), MAOB(4), MPO(4), MYST3(3), MYST4(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(4), TPO(12)	4881900	62	31	62	43	46	5	1	8	2	0	0.846	1.000	1.000
469	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(6), ACACB(3), ACADM(1), ACAT2(1), ACSS1(1), ACSS2(1), ALDH1B1(2), ALDH3A1(1), ALDH6A1(2), ALDH7A1(3), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(4), LDHA(1), LDHAL6A(4), LDHAL6B(1), LDHB(2), LDHC(2), MCEE(2), MUT(2), PCCA(2), SUCLG2(1)	5676934	47	31	47	21	24	5	3	12	3	0	0.410	1.000	1.000
470	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), CBL(1), CRKL(1), FOS(1), GRB2(1), IL2RA(1), IL2RB(2), IRS1(1), JAK1(2), JAK3(1), MAPK1(1), NMI(1), PIK3CA(3), PIK3R1(3), PTPN6(2), RAF1(3), SOCS3(1), SOS1(3), STAT5A(1), STAT5B(1), SYK(5)	5112193	38	31	38	17	24	2	2	5	4	1	0.448	1.000	1.000
471	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), AOC2(4), AOC3(2), DDC(4), GOT1(3), GOT2(1), HPD(2), LPO(5), MAOA(2), MAOB(4), MPO(4), PRDX6(1), TAT(4), TPO(12)	3121707	54	31	54	34	43	4	1	4	2	0	0.420	1.000	1.000
472	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	ALAD(1), CP(3), EPRS(5), GUSB(3), HCCS(2), HMOX1(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2B4(7)	3645406	39	31	39	21	23	5	2	4	5	0	0.670	1.000	1.000
473	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(6), ACAT2(1), ADH5(1), AKR1B1(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), DLAT(1), GRHPR(1), HAGH(1), LDHA(1), LDHB(2), LDHC(2), MDH2(1), ME1(8), ME2(1), ME3(4), PC(7), PCK1(3), PDHA1(1), PDHA2(6), PKLR(2), PKM2(1)	5275621	58	31	57	28	37	5	2	11	3	0	0.364	1.000	1.000
474	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(3), ARHGAP6(4), ARHGEF11(4), ARHGEF5(3), ARPC2(1), ARPC4(1), BAIAP2(3), CFL1(1), MYL2(1), MYLK(9), OPHN1(1), PIP5K1A(1), PIP5K1B(4), PPP1R12B(4), ROCK1(2), TLN1(2), VCL(2)	6402993	46	31	46	22	25	2	1	9	9	0	0.409	1.000	1.000
475	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), AKT1(3), AKT2(2), AKT3(1), DAG1(1), GNAQ(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PHKA2(3), PIK3CB(9), PITX2(1), PLD1(5), PLD2(1)	6364113	54	31	54	30	18	8	8	15	5	0	0.672	1.000	1.000
476	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(3), EGFR(4), ELK1(1), FOS(1), GRB2(1), JAK1(2), JUN(1), MAP2K1(3), MAP2K4(1), MAP3K1(1), PIK3CA(3), PIK3R1(3), PLCG1(6), PRKCA(2), RAF1(3), RASA1(1), SOS1(3), STAT3(6), STAT5A(1)	5337191	46	30	44	20	21	4	4	12	4	1	0.587	1.000	1.000
477	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(2), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(1), AOC2(4), AOC3(2), CNDP1(3), DDC(4), HAL(6), HARS(2), HDC(6), MAOA(2), MAOB(4), PRPS1(2), PRPS2(1)	3469170	48	30	48	30	32	5	1	5	5	0	0.623	1.000	1.000
478	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLG(4), POLG2(1), POLI(1), POLK(2), POLL(1), POLQ(7), PRIM1(2), PRIM2(5), REV3L(3)	5780075	37	30	37	16	24	1	1	6	5	0	0.614	1.000	1.000
479	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(6), ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), ATP7A(3), ATP7B(4), COX6B1(1), COX6C(1), COX7B(1), NDUFB2(1), NDUFB5(1), NDUFB6(1), NDUFV1(2), PPA2(2), SDHB(1), SHMT1(1), UQCRC1(2)	5464019	41	30	41	21	25	0	5	9	2	0	0.528	1.000	1.000
480	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1), MAPKAPK5(1), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2), PIK3CA(3), PIK3CD(3), PIK3R1(3), SYT1(8), TRAF3(2), TRAF5(2), TRAF6(1)	4748516	44	30	43	22	20	6	4	11	2	1	0.472	1.000	1.000
481	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(2), CARM1(1), CREBBP(4), EP300(1), ERCC3(1), ESR1(2), GRIP1(2), GTF2E1(1), GTF2F1(3), HDAC1(1), HDAC2(1), HDAC4(3), HDAC6(1), NCOR2(8), NR0B1(1), NRIP1(2), PELP1(1), POLR2A(4), TBP(2)	6462377	41	29	41	23	24	1	4	8	4	0	0.847	1.000	1.000
482	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(6), ATM(6), ATR(6), CCNA1(8), CCNE1(1), CDC25A(1), CDK6(1), CDKN1A(1), GSK3B(1), HDAC1(1), RB1(2), TGFB3(2)	4007200	36	29	36	19	19	3	3	7	3	1	0.725	1.000	1.000
483	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(1), ENPP7(1), GAL3ST1(3), GALC(1), GLB1(2), LCT(6), NEU1(3), NEU2(3), NEU3(1), NEU4(4), PPAP2C(1), SGMS1(3), SMPD1(2), SMPD3(2), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC2(1), UGT8(3)	5036568	40	29	40	32	23	4	1	8	4	0	0.958	1.000	1.000
484	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1), CYP2C19(6), CYP2C9(10), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(1), HADHA(4), MYST3(3), MYST4(2), PNPLA3(1), SH3GLB1(1)	4418569	46	29	45	32	26	8	1	8	3	0	0.916	1.000	1.000
485	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(1), GALNS(1), GLB1(2), GNS(1), GUSB(3), HEXB(1), HGSNAT(2), HPSE(4), IDS(4), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(2), MANBA(2), NAGLU(2), NEU1(3), NEU2(3), NEU3(1), NEU4(4), SPAM1(4)	4856168	54	29	54	23	34	4	1	9	6	0	0.231	1.000	1.000
486	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(1), FYN(1), IL7(2), IL7R(10), JAK1(2), JAK3(1), LCK(1), NMI(1), PIK3CA(3), PIK3R1(3), PTK2B(4), STAT5A(1), STAT5B(1)	3965796	35	29	35	16	18	3	1	9	3	1	0.585	1.000	1.000
487	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(2), AASDHPPT(3), AASS(2), ACAT2(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(1), EHHADH(2), EHMT1(1), EHMT2(5), GCDH(3), HADHA(4), PLOD1(2), PLOD2(1), PLOD3(2), SHMT1(1)	5247738	42	29	41	22	23	5	2	9	3	0	0.527	1.000	1.000
488	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(2), CDC42(2), DAXX(1), DDIT3(1), ELK1(1), GRB2(1), HSPB1(1), HSPB2(1), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K5(5), MAP3K9(5), MAPK14(2), MAPKAPK2(2), MAPKAPK5(1), MEF2A(1), MEF2D(1), MKNK1(2), PLA2G4A(4), RPS6KA5(1), TGFB3(2)	5117771	39	29	39	24	17	1	2	8	11	0	0.902	1.000	1.000
489	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(3), COMT(1), DBH(5), DDC(4), GAD1(5), GAD2(4), HDC(6), MAOA(2), PAH(3), TH(4), TPH1(2)	2001721	39	28	39	20	33	2	0	2	2	0	0.167	1.000	1.000
490	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), FYN(1), ITGA1(3), ITGB1(1), MAP2K1(3), MAPK1(1), MYL2(1), MYLK(9), PIK3CA(3), PIK3R1(3), PTK2(2), PXN(1), RAF1(3), ROCK1(2), TLN1(2)	5310694	38	28	36	21	21	3	3	7	3	1	0.724	1.000	1.000
491	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(5), GABRA2(8), GABRA3(7), GABRA4(4), GABRA6(8), GPHN(4), UBQLN1(1)	1677796	38	28	34	17	27	0	1	6	3	1	0.301	1.000	1.000
492	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), ESCO1(1), MYST3(3), MYST4(2), PNPLA3(1), SH3GLB1(1)	3578082	43	28	41	21	30	6	1	6	0	0	0.561	1.000	1.000
493	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(2), CAPN2(2), CXCR3(1), EGF(3), EGFR(4), ITGA1(3), ITGB1(1), MAPK1(1), MYL2(1), MYLK(9), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(2)	4618780	42	28	42	26	24	4	2	7	5	0	0.740	1.000	1.000
494	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2H1(1), MNAT1(2), POLR1A(2), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2H(2), POLR3B(7), POLR3E(2), POLR3H(1), TAF6(2), TAF7(1), TAF9(1), TBP(2)	5009792	38	28	38	14	16	5	6	11	0	0	0.380	1.000	1.000
495	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(2), BCR(2), BLNK(2), ELK1(1), FOS(1), GRB2(1), JUN(1), LYN(2), MAP2K1(3), MAP3K1(1), MAPK1(1), PAPPA(9), RPS6KA1(1), RPS6KA3(1), SOS1(3), SYK(5), VAV1(5), VAV3(1)	4472192	42	28	40	30	28	1	1	7	5	0	0.920	1.000	1.000
496	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(1), GLI2(8), GLI3(7), GSK3B(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), SHH(2), SMO(3), SUFU(1)	2361273	35	28	35	17	20	2	2	5	6	0	0.457	1.000	1.000
497	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(3), EGFR(4), GRB2(1), MAP2K1(3), MAPK1(1), PTPRB(17), RAF1(3), RASA1(1), SOS1(3), SPRY1(1), SPRY2(3), SPRY3(5)	3565978	46	28	42	22	31	4	1	7	3	0	0.591	1.000	1.000
498	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(6), ATR(6), BRCA1(2), BRCA2(9), CHEK1(1), CHEK2(1), FANCA(2), FANCC(1), FANCD2(3), FANCE(1), FANCG(1), HUS1(1), MRE11A(1), RAD17(1), RAD50(2), RAD9A(2)	6181751	40	27	40	23	24	2	2	10	2	0	0.917	1.000	1.000
499	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), CBX3(1), CLOCK(1), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(1), ETV6(3), GSTM3(1), GSTP1(1), HSPA8(2), IDI1(1), MYF6(4), NCKAP1(2), NCOA4(1), NR1D2(2), PER1(2), PER2(5), PPP1R3C(1), PURA(1), SF3A3(1), TUBB3(1), UCP3(3), ZFR(2)	5195887	42	27	42	21	18	4	2	9	9	0	0.776	1.000	1.000
500	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(9), F2(2), F2R(1), FGA(8), FGB(5), FGG(3), PLAU(1), PLG(4), SERPINB2(4), SERPINE1(1)	1906826	38	27	38	17	24	3	1	7	3	0	0.492	1.000	1.000
501	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(3), ADH1B(7), ADH1C(6), ADH4(3), ADH5(1), ADH6(3), ADH7(5), ALDH1B1(2), ALDH3A1(1), ALDH7A1(3), ALDH9A1(1)	1888368	35	27	33	16	25	4	2	3	1	0	0.287	1.000	1.000
502	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(8), ACE2(3), AGT(3), AGTR1(2), AGTR2(4), ANPEP(4), CMA1(1), CPA3(5), CTSA(1), CTSG(1), ENPEP(6), LNPEP(5), MAS1(1), MME(6), NLN(2), REN(3), THOP1(1)	3002697	56	27	55	31	39	6	4	6	1	0	0.398	1.000	1.000
503	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), CASP10(1), CASP3(1), CASP8(4), CD40(2), DAXX(1), DFFA(1), FAS(1), FASLG(4), IKBKE(4), MCL1(2), NFKB1(1), NFKBIA(1), NTRK1(5), PTPN13(4), SFRS2IP(2), TRAF1(1), TRAF3(2), TRAF6(1)	6179613	39	26	39	20	22	3	4	7	3	0	0.590	1.000	1.000
504	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(12), GNAI1(1), GNAS(5), MAPK1(1), MYT1(7), PIN1(1), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1)	2916351	38	26	38	24	22	3	3	3	7	0	0.692	1.000	1.000
505	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	17	AKR1B1(1), GUSB(3), UGDH(1), UGT1A1(2), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(1), UGT1A8(2), UGT1A9(4), UGT2B4(7)	2234011	29	26	29	16	21	2	2	1	3	0	0.469	1.000	1.000
506	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(6), ACADM(1), ACADSB(2), ACAT2(1), ALDH1A2(3), ALDH1B1(2), ALDH3A1(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(4), LDHA(1), LDHB(2), LDHC(2), MCEE(2), MUT(2), PCCA(2), SUCLG2(1)	4740648	39	26	39	18	19	6	2	10	2	0	0.544	1.000	1.000
507	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(3), CREB5(2), DUSP6(1), GRB2(1), MAP2K1(3), MAP2K2(2), MAPK1(1), MKNK1(2), MOS(1), NFKB1(1), RPS6KA1(1), RPS6KA2(5), RPS6KA3(1), SOS1(3), SOS2(4), TRAF3(2)	3973284	33	26	31	20	20	1	2	7	3	0	0.883	1.000	1.000
508	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), DAG1(1), ITPKB(1), ITPR1(10), ITPR2(3), ITPR3(3), NFAT5(2), PDE6B(2), PDE6C(7), PDE6D(1), PDE6G(1), SLC6A13(9), TF(3)	5066845	50	26	48	28	33	4	3	3	7	0	0.339	1.000	1.000
509	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(12), CFTR(11), GNAS(5), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(1)	1847008	39	25	39	19	23	3	4	3	6	0	0.400	1.000	1.000
510	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC3(3), CASP10(1), CASP3(1), CASP8(4), CHUK(1), DFFA(1), GAS2(3), LMNA(4), NFKB1(1), NFKBIA(1), RELA(2), SPTAN1(2), TNFRSF10A(3), TNFRSF25(1), TNFSF10(3)	4753130	32	25	32	17	16	4	3	9	0	0	0.723	1.000	1.000
511	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(6), ATR(6), BRCA1(2), CDC25A(1), CDC34(1), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(1), MDM2(2), MYT1(7), PRKDC(6), RPS6KA1(1), YWHAQ(1)	5887422	37	25	37	26	17	3	3	10	4	0	0.987	1.000	1.000
512	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(3), ACO2(1), CLYBL(2), CS(1), IDH1(3), IDH2(1), IDH3G(1), MDH2(1), OGDH(4), OGDHL(10), PC(7), PCK1(3), PCK2(1), SDHB(1), SUCLG2(1)	4270670	42	25	40	19	24	0	2	11	5	0	0.396	1.000	1.000
513	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(3), CA1(3), CA12(1), CA13(2), CA2(1), CA3(3), CA4(1), CA5A(1), CA6(1), CA7(1), CA8(2), CA9(2), CPS1(5), CTH(1), GLS(1), GLUL(2), HAL(6)	3006144	37	25	37	18	24	1	2	8	2	0	0.529	1.000	1.000
514	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(3), CA1(3), CA12(1), CA2(1), CA3(3), CA4(1), CA5A(1), CA6(1), CA7(1), CA8(2), CA9(2), CPS1(5), CTH(1), GLS(1), GLUL(2), HAL(6)	2687692	35	25	35	16	22	1	2	8	2	0	0.470	1.000	1.000
515	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), EGFR(4), IGF1R(4), POLR2A(4), PRKCA(2), RB1(2), TEP1(5), TERF1(1), TERT(1), TNKS(2), XRCC5(2)	3884923	30	25	30	20	18	3	1	5	2	1	0.770	1.000	1.000
516	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1G(1), EIF1AX(1), EIF2AK1(1), EIF2AK3(9), EIF2B1(3), EIF2S1(1), EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G3(4), EIF5B(1), GSPT2(2), KIAA0664(1), PABPC1(2), PABPC3(1), SLC35A4(2)	6213482	35	25	32	30	16	2	2	7	8	0	0.998	1.000	1.000
517	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(12), GNAS(5), PRKAA2(6), PRKAB1(1), PRKACB(3), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	2173625	38	24	38	16	22	3	4	2	7	0	0.284	1.000	1.000
518	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(1), CASP3(1), CASP8(4), DAXX(1), DFFA(1), FAF1(4), JUN(1), LMNA(4), LMNB1(1), LMNB2(2), MAP2K4(1), MAP3K1(1), PAK1(2), PAK2(5), PRKDC(6), PTPN13(4), RB1(2), RIPK2(1), SPTAN1(2)	5871848	44	24	44	21	15	4	6	16	2	1	0.819	1.000	1.000
519	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), MAP2K1(3), MAP2K2(2), MAP2K3(4), MAP2K6(1), MAP3K1(1), MAPK1(1), MAPK14(2), NFKB1(1), PIK3CA(3), PIK3R1(3), RB1(2), RELA(2)	2759754	28	24	26	12	12	3	0	8	3	2	0.623	1.000	1.000
520	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(1), CBS(1), CTH(1), GGT1(2), HEMK1(2), LCMT1(2), MARS(2), MARS2(1), MAT1A(2), MAT2B(2), METTL2B(2), METTL6(1), PAPSS1(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT8(1), SCLY(1), SEPHS1(1), WBSCR22(1)	3573864	30	24	30	16	14	3	3	5	5	0	0.558	1.000	1.000
521	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(8), ANAPC4(1), ANAPC5(2), ANAPC7(3), CDC23(2), CUL1(2), CUL2(1), FBXW11(1), FBXW7(4), FZR1(2), ITCH(1), SMURF2(1), UBA1(1), UBE2D1(1), VHL(1), WWP1(1), WWP2(1)	5685652	33	24	32	18	20	0	4	9	0	0	0.890	1.000	1.000
522	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), G6PD(1), GPI(1), H6PD(2), PFKM(1), PGD(2), PGLS(1), PGM1(3), PRPS1(2), PRPS1L1(2), PRPS2(1), RBKS(1), TAL1(3), TKT(4)	2901280	30	24	30	17	16	4	3	2	5	0	0.462	1.000	1.000
523	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(4), EGF(3), EGFR(4), GRB2(1), MET(8), PDGFRA(5), PRKCA(2), SH3GLB1(1), SH3KBP1(2)	2779235	31	23	31	19	18	5	2	3	3	0	0.786	1.000	1.000
524	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(1), DIAPH2(2), MCM10(3), MCM2(2), MCM3(1), MCM4(2), MCM5(1), MCM6(1), ORC1L(1), ORC4L(1), PCNA(2), POLA2(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(2), RPA1(2), RPA2(1), RPA3(1), RPA4(1), UBC(1)	7217372	37	23	37	24	18	2	1	11	5	0	0.917	1.000	1.000
525	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(4), MAP2K1(3), MAP3K1(1), MAPK14(2), NCOR2(8), RARA(2), THRA(1), THRB(5)	2447385	29	23	27	15	20	2	1	5	1	0	0.548	1.000	1.000
526	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), FPGT(1), GCK(5), GMDS(2), GMPPA(1), HK1(2), HK2(4), HK3(3), PFKFB1(2), PFKM(1)	3382738	28	23	28	20	20	2	2	2	2	0	0.560	1.000	1.000
527	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), AKR1B10(3), ALDOB(2), ALDOC(2), FBP1(1), FBP2(1), FPGT(1), FUK(1), GMDS(2), GMPPA(1), HK1(2), HK2(4), HK3(3), HSD3B7(2), MTMR1(2), MTMR2(1), PFKFB1(2), PFKL(2), PFKM(1), RDH11(1), RDH12(1), RDH13(1), TSTA3(1)	5244589	38	23	38	27	23	4	3	6	2	0	0.682	1.000	1.000
528	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(3), CHIT1(3), CMAS(1), CTBS(1), GFPT1(2), GFPT2(3), GNE(1), HEXB(1), HK1(2), HK2(4), HK3(3), MTMR1(2), MTMR2(1), RENBP(2), UAP1(1)	4073534	30	23	30	17	15	2	2	5	6	0	0.677	1.000	1.000
529	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT3(4), AGPAT4(1), AGPAT6(1), AGPS(1), ENPP2(1), ENPP6(3), PAFAH1B1(2), PLA2G2D(2), PLA2G2E(1), PLA2G3(2), PLA2G4A(4), PLA2G6(2), PLD1(5), PLD2(1), PPAP2C(1)	3326533	31	23	31	16	16	5	2	6	2	0	0.536	1.000	1.000
530	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), ENPP1(4), ENPP3(4), NADK(1), NMNAT2(1), NMNAT3(5), NNMT(1), NT5C1A(1), NT5C1B(6), NT5C2(2), NT5E(1), QPRT(2)	3077396	33	23	33	25	19	2	1	6	5	0	0.948	1.000	1.000
531	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(7), ABP1(2), AOC2(4), AOC3(2), CES1(3), CES7(3), DDHD1(1), ESCO1(1), MYST3(3), MYST4(2), PLA1A(3), PNPLA3(1), PRDX6(1), SH3GLB1(1)	3616767	34	23	34	20	26	1	1	5	1	0	0.782	1.000	1.000
532	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	ELK1(1), FOS(1), GRB2(1), IGF1(5), IGF1R(4), IRS1(1), JUN(1), MAP2K1(3), PIK3CA(3), PIK3R1(3), PTPN11(2), RAF1(3), RASA1(1), SOS1(3)	3531501	32	23	30	13	18	2	1	8	2	1	0.508	1.000	1.000
533	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(9), ABCB11(5), ABCB4(4), ABCC1(4), ABCC3(6), GSTP1(1)	2034271	29	23	28	17	13	4	3	3	6	0	0.370	1.000	1.000
534	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(1), GLB1(2), GNS(1), GUSB(3), HEXB(1), HGSNAT(2), HPSE(4), IDS(4), LCT(6), NAGLU(2), SPAM1(4)	2898921	31	22	31	15	24	0	0	3	4	0	0.420	1.000	1.000
535	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(4), EP300(1), IKBKB(3), IL1B(2), MAP2K3(4), MAP2K6(1), MAPK11(1), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(2), TGFBR2(2), TLR2(2)	4232733	27	22	26	19	9	6	1	9	2	0	0.962	1.000	1.000
536	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(12), GNAS(5), PLCE1(10), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	2081085	37	22	37	17	22	2	3	4	6	0	0.367	1.000	1.000
537	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(6), CASP3(1), CREB5(2), DAG1(1), EPHB2(8), FOS(1), GNAQ(1), ITPKB(1), JUN(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8IP1(1), MAPK8IP2(1), MAPK9(1)	4049520	30	22	30	13	17	3	3	3	4	0	0.376	1.000	1.000
538	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	GBA3(4), LPO(5), MPO(4), PRDX6(1), TPO(12), TYR(4)	1377357	30	22	30	18	22	3	0	1	4	0	0.553	1.000	1.000
539	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(3), CASP3(1), CASP8(4), DFFA(1), JUN(1), LMNA(4), LMNB1(1), LMNB2(2), MADD(4), MAP2K4(1), MAP3K1(1), PAK1(2), PAK2(5), PRKDC(6), RB1(2), SPTAN1(2)	5563329	40	22	40	20	13	4	6	16	0	1	0.774	1.000	1.000
540	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(12), FHL5(3), FSHB(2), FSHR(5), GNAS(5), XPO1(2)	1350286	29	21	28	13	18	2	4	2	3	0	0.393	1.000	1.000
541	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSE(1), GAL3ST1(3), GALC(1), GLB1(2), LCT(6), NEU1(3), NEU2(3), NEU3(1), NEU4(4), PPAP2C(1), SMPD1(2), SPTLC2(1)	3409283	29	21	29	17	16	4	0	5	4	0	0.665	1.000	1.000
542	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(4), G6PD(1), GCLC(1), GGT1(2), GPX1(1), GPX5(2), GPX6(3), GSS(2), GSTA1(2), GSTM3(1), GSTM5(1), GSTP1(1), IDH1(3), IDH2(1), MGST1(1), MGST2(1), MGST3(1), OPLAH(2), TXNDC12(1)	3105743	31	21	30	16	19	3	2	6	1	0	0.332	1.000	1.000
543	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), GLB1(2), HEXB(1), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(2), MANBA(2), NEU1(3), NEU2(3), NEU3(1), NEU4(4)	2881714	32	21	32	16	18	4	1	6	3	0	0.497	1.000	1.000
544	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(1), ATG7(3), GABARAPL1(1), IFNA1(1), IFNA16(3), IFNA21(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNG(1), PIK3C3(1), PIK3R4(1), PRKAA2(6), ULK1(1), ULK2(3), ULK3(1)	2977990	32	21	32	17	18	0	3	8	3	0	0.660	1.000	1.000
545	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(9), FYN(1), RELN(16), VLDLR(1)	2003659	28	21	28	17	18	3	1	4	2	0	0.832	1.000	1.000
546	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(6), AXIN1(3), CREBBP(4), CSNK1A1(1), CTNNB1(6), FZD1(2), GSK3B(1), HDAC1(1), NLK(1), TLE1(2), WNT1(1)	4159683	28	21	28	13	11	2	2	7	6	0	0.721	1.000	1.000
547	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(6), ATM(6), BRCA1(2), CDKN1A(1), CHEK1(1), CHEK2(1), JUN(1), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(2), RBBP8(1), RELA(2), TP73(1)	4122227	29	20	29	15	9	5	1	11	3	0	0.893	1.000	1.000
548	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(1), DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(1), GCDH(3), HADHA(4), MYST3(3), MYST4(2), PNPLA3(1), SH3GLB1(1)	3719272	27	20	27	15	15	5	0	7	0	0	0.753	1.000	1.000
549	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	GBA3(4), LPO(5), MPO(4), PRDX6(1), TPO(12)	1193436	26	20	26	17	21	2	0	1	2	0	0.557	1.000	1.000
550	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(1), POLR2A(4), POLR2B(4), POLR2C(1), POLR2D(1), POLR2H(2), POLR3B(7), POLR3H(1)	3351636	23	20	23	13	9	4	4	5	1	0	0.760	1.000	1.000
551	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CXCR3(1), ETV5(1), IFNG(1), IL12RB1(3), IL18R1(4), JAK2(2), JUN(1), MAP2K6(1), MAPK14(2), STAT4(9), TYK2(1)	2643527	26	20	25	14	13	0	1	4	8	0	0.736	1.000	1.000
552	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(3), IL1A(1), IL1R1(2), IRAK1(3), MAP3K1(1), NFKB1(1), NFKBIA(1), RELA(2), TLR4(6), TRAF6(1)	3423556	22	20	22	14	15	3	1	3	0	0	0.782	1.000	1.000
553	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(6), CD4(5), CXCR3(1), IFNG(1), IL12RB1(3), JAK2(2), STAT4(9), TYK2(1)	2071805	28	20	26	13	18	1	1	2	6	0	0.377	1.000	1.000
554	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(3), CHUK(1), IKBKB(3), JUN(1), MAP2K3(4), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP4K2(2), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(2)	3387475	23	20	23	13	8	6	2	6	1	0	0.726	1.000	1.000
555	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IFNG(1), IFNGR1(1), IFNGR2(2), IKBKB(3), JAK2(2), LIN7A(4), NFKB1(1), NFKBIA(1), RB1(2), RELA(2), USH1C(6)	2464818	25	20	25	12	12	2	1	4	5	1	0.644	1.000	1.000
556	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), GRB2(1), MAPK1(1), MAPK7(1), MEF2A(1), MEF2D(1), NTRK1(5), PIK3CA(3), PIK3R1(3), PLCG1(6), RPS6KA1(1)	2686765	26	19	26	17	14	3	1	4	3	1	0.836	1.000	1.000
557	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(1), COPS5(2), EDN1(3), EP300(1), EPO(2), HIF1A(3), JUN(1), LDHA(1), NOS3(6), P4HB(1), VHL(1)	2445862	24	19	23	10	14	0	2	5	3	0	0.599	1.000	1.000
558	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(6), CPT1A(3), LEP(1), LEPR(4), PRKAA2(6), PRKAB1(1), PRKAG1(1), PRKAG2(3)	2082070	25	19	25	16	15	2	2	3	3	0	0.866	1.000	1.000
559	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), GLB1(2), HEXB(1), LCT(6), MAN2C1(2), MANBA(2), NEU1(3), NEU2(3), NEU3(1), NEU4(4)	2339652	27	19	27	14	14	3	1	6	3	0	0.638	1.000	1.000
560	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(1), DNMT1(6), MTNR1A(1), MTNR1B(2), PTAFR(1), PTGDR(3), PTGER2(2), PTGFR(1), PTGIR(1)	1585926	19	19	19	21	10	2	0	2	5	0	0.888	1.000	1.000
561	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(3), BIRC3(3), CASP3(1), CASP8(4), JUN(1), MAP2K4(1), MAP3K3(2), NFKB1(1), NFKB2(2), NFKBIA(1), NFKBIL1(2), NFKBIL2(2)	3842442	23	19	23	19	7	1	6	9	0	0	0.980	1.000	1.000
562	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(5), GFPT1(2), GNE(1), HEXB(1), HK1(2), HK2(4), HK3(3), RENBP(2), UAP1(1)	2414600	22	18	22	10	12	0	1	3	6	0	0.411	1.000	1.000
563	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), LPO(5), MPO(4), PRDX6(1), SHMT1(1), TPO(12)	1662810	25	18	25	21	20	2	0	2	1	0	0.843	1.000	1.000
564	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(4), JAK1(2), JAK2(2), JAK3(1), SOCS3(1), STAT3(6), STAT5A(1), STAT5B(1), TYK2(1)	2589870	21	18	21	14	8	3	2	5	3	0	0.878	1.000	1.000
565	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), LPO(5), MPO(4), PRDX6(1), SHMT1(1), TPO(12)	1683278	25	18	25	20	20	2	0	2	1	0	0.817	1.000	1.000
566	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), ENPP1(4), ENPP3(4), NMNAT2(1), NNMT(1), NT5E(1), QPRT(2)	2083066	18	18	18	12	9	2	1	5	1	0	0.874	1.000	1.000
567	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(9), AKT1(3), ATM(6), CDKN1A(1), CSNK1A1(1), HIC1(1), HIF1A(3), MDM2(2), NQO1(1)	2854013	27	18	26	14	13	2	1	7	4	0	0.786	1.000	1.000
568	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(6), AXIN1(3), CTNNB1(6), FZD1(2), GSK3B(1), NOTCH1(1), PSEN1(1), WNT1(1)	3000580	22	18	22	13	12	2	1	2	5	0	0.782	1.000	1.000
569	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(3), CCNE1(1), CDK6(1), CDKN1A(1), MAPK1(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3CA(3), PIK3R1(3), RAF1(3), RB1(2), RELA(2)	2718190	24	18	24	12	9	1	3	7	2	2	0.713	1.000	1.000
570	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREBBP(4), EP300(1), NCOA3(4), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1), RARA(2)	2948181	22	17	22	12	11	0	0	7	4	0	0.839	1.000	1.000
571	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), ACO2(1), CS(1), IDH1(3), IDH2(1), IDH3G(1), MDH2(1), PC(7), PCK1(3), SDHB(1), SUCLG2(1)	2956519	23	17	21	11	14	0	2	5	2	0	0.518	1.000	1.000
572	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD80(3), CD86(3), GRB2(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), ITK(2), LCK(1), PIK3CA(3), PIK3R1(3), PTPN11(2)	1824512	23	17	23	10	9	1	0	11	1	1	0.805	1.000	1.000
573	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(2), EPHB1(3), FYN(1), ITGA1(3), ITGB1(1), L1CAM(2), LYN(2), SELP(11)	2251383	25	17	23	19	17	2	1	4	1	0	0.908	1.000	1.000
574	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(6), CDH1(3), CREBBP(4), EP300(1), MAP2K1(3), SKIL(2), TGFB3(2), TGFBR2(2)	3673213	23	17	21	13	10	3	0	5	5	0	0.882	1.000	1.000
575	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), SYT1(8)	1655920	21	16	20	16	13	4	1	1	2	0	0.788	1.000	1.000
576	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(1), GLB1(2), GNS(1), GUSB(3), HEXB(1), IDS(4), LCT(6), NAGLU(2)	2034538	21	16	21	12	17	0	0	2	2	0	0.606	1.000	1.000
577	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL11(1), RPL18(1), RPL21(1), RPL27(2), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL36AL(1), RPL38(1), RPL3L(1), RPS11(1), RPS16(1), RPS23(1), RPS7(3), RPS8(1)	3203960	20	16	20	15	7	1	4	5	3	0	0.932	1.000	1.000
578	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), DDOST(1), DPAGT1(1), FUT8(2), MAN1A1(5), MGAT1(1), MGAT3(2), MGAT4A(3), MGAT4B(1), ST6GAL1(1)	2845499	22	16	22	12	15	2	0	1	4	0	0.536	1.000	1.000
579	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(1), GALNT10(5), GALNT2(1), GALNT6(2), GALNT7(2), GALNT8(5), GALNT9(2), GCNT1(3), ST3GAL2(1)	1893998	22	16	21	11	15	0	1	2	4	0	0.514	1.000	1.000
580	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(6), CDC25A(1), CHEK1(1), MYT1(7), RB1(2)	2307496	17	16	17	10	9	2	0	3	2	1	0.814	1.000	1.000
581	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6R(1), JAK1(2), JAK2(2), JAK3(1), PIAS3(2), PTPRU(2), REG1A(2), STAT3(6)	2161683	20	16	20	11	9	2	0	6	3	0	0.752	1.000	1.000
582	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTN1(1), ACTN2(4), CAPN1(2), ITGA1(3), ITGB1(1), ITGB3(3), PTK2(2), PXN(1), SPTAN1(2), TLN1(2)	3947211	21	16	21	15	10	4	2	4	1	0	0.772	1.000	1.000
583	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(4), MAP2K1(3), MAP2K4(1), MAP3K1(1), MAPK1(1), NFKB1(1), NSMAF(1), RAF1(3), RELA(2), SMPD1(2)	2906926	19	15	17	10	8	1	3	5	2	0	0.704	1.000	1.000
584	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT2(1), B4GALT3(1), B4GALT4(1), CHST1(1), CHST4(3), CHST6(1), FUT8(2), ST3GAL2(1), ST3GAL3(1)	1770269	17	15	16	10	14	1	1	0	1	0	0.505	1.000	1.000
585	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(2), FTCD(1), GART(2), MTHFD1(3), MTR(4), SHMT1(1), TYMS(1)	2699315	18	15	18	13	10	0	2	4	2	0	0.895	1.000	1.000
586	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(1), NPAS2(1), PER1(2), PER2(5), PER3(4)	2425068	17	15	16	12	13	2	0	0	2	0	0.814	1.000	1.000
587	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), GLB1(2), HEXB(1), LCT(6), SLC33A1(2), ST3GAL2(1), ST6GALNAC5(3), ST8SIA1(1)	2345361	18	14	18	10	13	1	1	1	2	0	0.540	1.000	1.000
588	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(10)	289574	16	14	15	12	12	2	0	0	2	0	0.762	1.000	1.000
589	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(2), GART(2), MTHFD1(3), MTR(4), SHMT1(1), TYMS(1)	2548429	17	14	17	10	9	0	2	4	2	0	0.736	1.000	1.000
590	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(3), COPA(1), GBF1(3), GPLD1(7), KDELR3(1)	2335989	15	13	15	11	5	0	2	7	1	0	0.914	1.000	1.000
591	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(3), MAP3K1(1), NFKB1(1), NFKBIA(1), RELA(2), TRAF3(2), TRAF6(1)	2576906	14	13	14	8	8	3	1	2	0	0	0.714	1.000	1.000
592	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), JUN(1), OPRK1(5), POLR2A(4), PRKACB(3), PRKACG(3), PRKAR1A(1), PRKAR1B(1), PRKAR2A(1), PRKAR2B(1)	1829534	21	13	21	13	14	0	1	3	3	0	0.647	1.000	1.000
593	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(3), EGFR(4), HGS(1), RAB5A(1), TF(3), TFRC(3)	1832484	16	13	16	10	7	2	2	4	1	0	0.864	1.000	1.000
594	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACSL1(1), CPT1A(3), DCI(1), EHHADH(2), HADHA(4), SLC25A20(1)	2420805	13	13	13	10	5	2	1	3	2	0	0.926	1.000	1.000
595	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(3), MAP3K1(1), NFKB1(1), NFKBIA(1), RELA(2), TRAF1(1), TRAF3(2)	3178319	14	13	14	11	8	3	1	2	0	0	0.890	1.000	1.000
596	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), SHMT1(1)	2148973	15	12	15	11	8	0	2	5	0	0	0.864	1.000	1.000
597	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(2), LCT(6), PGM1(3), PYGL(1), PYGM(1), TREH(1)	1877938	14	12	14	10	12	0	1	0	1	0	0.555	1.000	1.000
598	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), SHMT1(1)	2148973	15	12	15	11	8	0	2	5	0	0	0.864	1.000	1.000
599	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), FDXR(1), SHMT1(1)	2285523	16	12	16	12	8	0	2	5	1	0	0.877	1.000	1.000
600	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(6), ATR(6), CHEK1(1), CHEK2(1)	2172171	14	12	14	10	7	1	1	4	1	0	0.943	1.000	1.000
601	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(4), DAXX(1), PAX3(1), PML(1), RARA(2), RB1(2), SP100(3)	2564192	14	12	14	10	4	2	0	7	0	1	0.920	1.000	1.000
602	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B1(3), ATP6V1C2(2), ATP6V1G3(1), SHMT1(1)	2148973	15	12	15	11	8	0	2	5	0	0	0.864	1.000	1.000
603	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(2), AOC2(4), AOC3(2), CES1(3)	858422	11	11	11	9	10	0	0	1	0	0	0.816	1.000	1.000
604	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(3), DHRS3(2), DHRS7(1), ESCO1(1), MYST3(3), MYST4(2), PNPLA3(1), SH3GLB1(1)	2375914	15	11	15	10	8	3	0	4	0	0	0.869	1.000	1.000
605	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(7), MEF2A(1), MEF2D(1)	1067375	12	11	12	10	10	1	0	0	1	0	0.876	1.000	1.000
606	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(4), EP300(1), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(2), TRAF6(1)	3177702	14	11	14	10	3	3	1	6	1	0	0.945	1.000	1.000
607	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), CASP10(1), CASP3(1), CASP8(4), GZMB(1), JUN(1)	1844690	12	10	12	7	6	0	1	5	0	0	0.856	1.000	1.000
608	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAD(1), ALAS1(1), ALAS2(3), CPO(1), HBB(2)	1090247	8	8	8	10	6	0	0	1	1	0	0.971	1.000	1.000
609	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAT2(1), ECHS1(1), EHHADH(2), HADHA(4)	1192029	8	7	8	6	4	2	0	2	0	0	0.899	1.000	1.000
610	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5)	696182	5	5	5	6	3	0	1	1	0	0	0.948	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(4)	320770	4	4	4	6	2	1	1	0	0	0	0.961	1.000	1.000
612	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1), GLS(1), PRODH(1)	775098	3	3	3	5	0	1	1	1	0	0	0.979	1.000	1.000
613	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC2(1), APOBEC3F(1)	1055352	3	3	3	8	2	1	0	0	0	0	0.997	1.000	1.000
614	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), NOTCH1(1), PSEN1(1)	1304185	3	3	3	5	3	0	0	0	0	0	0.943	1.000	1.000
615	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(1)	895698	1	1	1	3	0	0	1	0	0	0	0.997	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		161310	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
