E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.074 0.18 -9999.0 0.0 -0.348 18.0 18.0 KLHL20 -0.023 0.085 0.152 1.0 -0.225 4.0 5.0 CYFIP2 0.021 0.063 0.184 2.0 -0.283 2.0 4.0 Rac1/GDP -0.033 0.114 0.212 1.0 -0.215 12.0 13.0 ENAH -0.052 0.177 0.247 3.0 -0.346 15.0 18.0 AP1M1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.008 0.073 0.143 1.0 -9999.0 0.0 1.0 ABI1/Sra1/Nap1 -0.033 0.05 -9999.0 0.0 -0.144 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.011 0.124 -9999.0 0.0 -0.154 20.0 20.0 RAPGEF1 -0.056 0.16 0.223 2.0 -0.319 14.0 16.0 CTNND1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.066 0.189 -9999.0 0.0 -0.354 18.0 18.0 CRK -0.055 0.165 0.236 1.0 -0.329 15.0 16.0 E-cadherin/gamma catenin/alpha catenin 0.018 0.121 0.165 13.0 -0.175 15.0 28.0 alphaE/beta7 Integrin 0.016 0.067 -9999.0 0.0 -0.184 6.0 6.0 IQGAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.034 -9999.0 0.0 -0.149 1.0 1.0 DLG1 -0.074 0.18 -9999.0 0.0 -0.348 18.0 18.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.03 0.041 -9999.0 0.0 -0.114 9.0 9.0 MLLT4 0.02 0.04 -9999.0 0.0 -0.283 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.045 0.045 0.149 1.0 -0.139 3.0 4.0 PI3K -0.036 0.053 -9999.0 0.0 -0.143 9.0 9.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.007 0.132 0.16 14.0 -0.206 15.0 29.0 TIAM1 0.015 0.07 0.184 1.0 -0.283 3.0 4.0 E-cadherin(dimer)/Ca2+ 0.027 0.105 -9999.0 0.0 -0.143 15.0 15.0 AKT1 -0.022 0.041 0.102 1.0 -9999.0 0.0 1.0 PIK3R1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.015 0.163 0.184 13.0 -0.283 15.0 28.0 RhoA/GDP -0.022 0.125 0.223 3.0 -0.215 12.0 15.0 actin cytoskeleton organization -0.016 0.065 0.125 1.0 -0.164 4.0 5.0 CDC42/GDP -0.022 0.124 0.223 3.0 -0.215 11.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.025 0.096 -9999.0 0.0 -0.181 16.0 16.0 ITGB7 -0.002 0.092 -9999.0 0.0 -0.283 6.0 6.0 RAC1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.029 0.113 -9999.0 0.0 -0.153 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.017 0.096 0.139 12.0 -0.138 15.0 27.0 mol:GDP -0.037 0.131 0.225 3.0 -0.241 12.0 15.0 CDC42/GTP/IQGAP1 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.031 0.052 0.184 3.0 -0.283 1.0 4.0 p120 catenin/RhoA/GDP -0.013 0.129 0.231 3.0 -0.221 11.0 14.0 RAC1/GTP/IQGAP1 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.001 0.058 0.139 3.0 -0.106 4.0 7.0 NME1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.075 0.178 -9999.0 0.0 -0.347 18.0 18.0 regulation of cell-cell adhesion -0.016 0.057 -9999.0 0.0 -0.13 8.0 8.0 WASF2 -0.009 0.039 -9999.0 0.0 -0.087 2.0 2.0 Rap1/GTP -0.008 0.081 0.183 1.0 -9999.0 0.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.017 0.129 0.263 1.0 -0.155 19.0 20.0 CCND1 -0.002 0.068 0.183 2.0 -0.128 4.0 6.0 VAV2 -0.075 0.234 -9999.0 0.0 -0.673 4.0 4.0 RAP1/GDP -0.012 0.097 0.199 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.072 0.174 -9999.0 0.0 -0.337 18.0 18.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.005 0.116 -9999.0 0.0 -0.152 19.0 19.0 E-cadherin/beta catenin -0.047 0.127 -9999.0 0.0 -0.257 16.0 16.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.058 0.178 0.246 2.0 -0.345 16.0 18.0 PIK3CA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.061 0.114 -9999.0 0.0 -0.359 4.0 4.0 E-cadherin/beta catenin/alpha catenin 0.017 0.113 -9999.0 0.0 -0.166 15.0 15.0 ITGAE 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.067 0.192 -9999.0 0.0 -0.361 18.0 18.0