Skin Cutaneous Melanoma: Mutation Analysis (MutSig v2.0)
(WT cohort)
Maintained by Dan DiCara (Broad Institute)
- Overview
+ Introduction
- Summary
  • MAF used for this analysis:SKCM-WT.final_analysis_set.maf

  • Significantly mutated genes (q ≤ 0.1): 5

  • Mutations seen in COSMIC: 53

  • Significantly mutated genes in COSMIC territory: 5

  • Genes with clustered mutations (≤ 3 aa apart): 156

  • Significantly mutated genesets: 0

  • Significantly mutated genesets: (excluding sig. mutated genes):0

Mutation Preprocessing
  • Read 34 MAFs of type "Broad"

  • Total number of mutations in input MAFs: 19965

  • After removing 101 blacklisted mutations: 19864

  • After removing 334 noncoding mutations: 19530

Mutation Filtering
  • Number of mutations before filtering: 19530

  • After removing 261 mutations outside gene set: 19269

  • After removing 23 mutations outside category set: 19246

  • After removing 4 "impossible" mutations in

  • gene-patient-category bins of zero coverage: 18958

- Results
+ Breakdown of Mutations by Type
+ Breakdown of Mutation Rates by Category Type
+ Target Coverage for Each Individual
+ Distribution of Mutation Counts, Coverage, and Mutation Rates Across Samples
+ CoMut Plot
+ Significantly Mutated Genes
+ COSMIC analyses
+ Clustered Mutations
+ Geneset Analyses
+ Methods & Data