Skin Cutaneous Melanoma: HotNet pathway analysis of mutation and copy number data
(WT cohort)
(WT cohort)
Maintained by Hailei Zhang
(Broad Institute)
Overview
Introduction
Summary
There were 3 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 3 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 3 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| PDGFRA(11),PDGFC(10),SHF(11) | 3 | 0.0015 | 1 |
| POLA2(2),MAPK9(8),XPNPEP1(18) | 3 | 0.0015 | 1 |
| UVRAG(1),VPS11(1),VPS18(11) | 3 | 0.0015 | 1 |
Methods & Data
Copyright © 2013
Broad Institute TCGA GDAC as part of the TCGA Research Network.
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