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MAF used for this analysis:THCA.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 27
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 27. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| BRAF | 84303 | 0 | 1 | 183 | 0 | 0 | 0 |
| NRAS | 23793 | 0 | 0 | 26 | 0 | 0 | 0 |
| HRAS | 22606 | 0 | 0 | 12 | 0 | 0 | 0 |
| EMG1 | 30471 | 0 | 0 | 6 | 6 | 0 | 0 |
| TG | 318793 | 0 | 3 | 16 | 10 | 1.5e-153 | 5.5e-150 |
| EIF1AX | 18088 | 0 | 0 | 6 | 1 | 1.3e-64 | 4.2e-61 |
| MUC7 | 33160 | 0 | 1 | 5 | 1 | 2.6e-43 | 7.1e-40 |
| ZNF845 | 78752 | 0 | 0 | 6 | 0 | 1.5e-35 | 3.4e-32 |
| RPTN | 83871 | 0 | 0 | 8 | 7 | 3.5e-35 | 7.3e-32 |
| PPM1D | 56848 | 0 | 0 | 5 | 4 | 1.4e-25 | 2.7e-22 |
| TROAP | 68476 | 0 | 0 | 5 | 0 | 2.4e-21 | 4.1e-18 |
| GPR44 | 14753 | 0 | 0 | 4 | 4 | 1.5e-18 | 2.4e-15 |
| PRG4 | 148467 | 0 | 1 | 7 | 3 | 8.3e-17 | 1.2e-13 |
| FAM47C | 90339 | 0 | 3 | 5 | 0 | 2.3e-16 | 3.1e-13 |
| ARID1B | 175821 | 0 | 0 | 6 | 2 | 2.5e-16 | 3.1e-13 |
| DNMT3A | 91623 | 0 | 0 | 5 | 4 | 3.8e-16 | 4.5e-13 |
| ZNF799 | 73430 | 0 | 1 | 5 | 0 | 1.2e-14 | 1.3e-11 |
| CCDC15 | 86277 | 0 | 1 | 5 | 0 | 2.2e-12 | 2.3e-09 |
| MLL3 | 523575 | 0 | 0 | 8 | 4 | 1.8e-11 | 1.8e-08 |
| ZNF780A | 77399 | 0 | 1 | 4 | 0 | 4.1e-11 | 3.9e-08 |
| ZFHX3 | 379957 | 0 | 2 | 8 | 2 | 3.4e-07 | 0.00031 |
| DICER1 | 232455 | 0 | 0 | 5 | 2 | 8.4e-07 | 0.00072 |
| COL5A3 | 116809 | 0 | 0 | 6 | 2 | 1.1e-06 | 0.00093 |
| LRP1 | 476861 | 0 | 1 | 6 | 2 | 1.8e-06 | 0.0014 |
| ZNF208 | 161113 | 1 | 0 | 4 | 0 | 4.4e-06 | 0.0033 |
| CHD2 | 219636 | 0 | 0 | 4 | 4 | 0.000022 | 0.016 |
| CD209 | 45543 | 0 | 1 | 4 | 0 | 0.000097 | 0.068 |
| ANK1 | 210063 | 0 | 0 | 4 | 0 | 0.00019 | 0.13 |
| ATM | 388254 | 0 | 0 | 5 | 2 | 0.00023 | 0.15 |
| PKHD1L1 | 454465 | 0 | 0 | 5 | 4 | 0.00078 | 0.49 |
| PRDM9 | 98838 | 0 | 3 | 6 | 1 | 0.0014 | 0.84 |
| ACRC | 65795 | 0 | 0 | 4 | 0 | 0.0017 | 0.98 |
| DNAH2 | 521217 | 0 | 0 | 5 | 0 | 0.0019 | 1 |
| APOB | 567507 | 0 | 0 | 5 | 1 | 0.0032 | 1 |
| MAP3K3 | 74181 | 0 | 0 | 4 | 1 | 0.0034 | 1 |
