rank	geneset	description	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	p	q
1	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	13	CREB1(1), KEAP1(18), PRKCA(2)	43641	21	20	20	1	3	13	1	2	2	<1.00e-11	<6.21e-10
2	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	28	CHRNA1(3), FLT4(5), NOS3(1), RYR2(44), SLC7A1(1)	239584	54	38	54	11	13	17	14	5	5	<1.00e-11	<6.21e-10
3	HSA04720_LONG_TERM_ POTENTIATION	Genes involved in long-term potentiation	67	ADCY8(7), ARAF(1), BRAF(4), CACNA1C(8), CAMK2A(1), CAMK2B(3), CAMK2D(1), CAMK4(3), CREBBP(2), GRIA1(3), GRIN2B(8), GRM1(8), ITPR1(2), ITPR2(6), ITPR3(4), KRAS(5), PLCB1(5), PLCB4(3), PPP3CC(1), PRKCA(2), RPS6KA2(1)	401402	78	50	75	25	25	24	15	3	11	<1.00e-11	<6.21e-10
4	STRIATED_MUSCLE_ CONTRACTION		37	ACTN3(2), DMD(12), MYBPC2(1), MYBPC3(3), MYH6(7), MYH7(5), MYH8(10), MYOM1(2), NEB(10), TPM2(1), TPM4(1), TTN(83)	734050	137	66	137	42	37	49	28	11	12	<1.00e-11	<6.21e-10
5	HSA04020_CALCIUM_ SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	169	ADCY2(4), ADCY3(1), ADCY4(1), ADCY8(7), ATP2A3(1), ATP2B1(1), ATP2B2(4), ATP2B4(1), CACNA1A(1), CACNA1C(8), CACNA1D(6), CACNA1E(19), CACNA1F(2), CACNA1G(4), CACNA1H(1), CACNA1I(1), CAMK2A(1), CAMK2B(3), CAMK2D(1), CAMK4(3), EGFR(7), GNA11(1), GNAS(3), GRM1(8), ITPR1(2), ITPR2(6), ITPR3(4), MYLK(4), NOS3(1), PDE1A(1), PDE1B(1), PDGFRB(3), PLCB1(5), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(2), PPP3CC(1), PRKCA(2), PTK2B(2), RYR1(17), RYR2(44), RYR3(15), SLC8A2(1), SLC8A3(4)	1446030	210	81	208	66	52	72	52	10	24	<1.00e-11	<6.21e-10
6	HSA04912_GNRH_SIGNALING_ PATHWAY	Genes involved in GnRH signaling pathway	95	ADCY2(4), ADCY3(1), ADCY4(1), ADCY5(4), ADCY8(7), CACNA1C(8), CACNA1D(6), CACNA1F(2), CAMK2A(1), CAMK2B(3), CAMK2D(1), EGFR(7), GNA11(1), GNAS(3), ITPR1(2), ITPR2(6), ITPR3(4), KRAS(5), MAP2K4(1), MAP2K6(1), PLA2G4A(3), PLCB1(5), PLCB4(3), PRKCA(2), PTK2B(2), SOS1(3)	606893	86	53	81	34	20	23	22	6	15	<1.00e-11	<6.21e-10
7	CALCIUM_REGULATION_ IN_CARDIAC_CELLS		139	ADCY2(4), ADCY3(1), ADCY4(1), ADCY5(4), ADCY8(7), ATP2A3(1), ATP2B1(1), ATP2B2(4), CACNA1A(1), CACNA1C(8), CACNA1D(6), CACNA1E(19), CAMK2A(1), CAMK2B(3), CAMK2D(1), CAMK4(3), GJB1(1), GNA11(1), GRK4(2), GRK6(1), ITPR1(2), ITPR2(6), ITPR3(4), PRKCA(2), PRKCE(1), RYR1(17), RYR2(44), RYR3(15), SLC8A3(4)	1280902	165	70	165	58	38	58	41	7	21	<1.00e-11	<6.21e-10
8	HSA04512_ECM_RECEPTOR_ INTERACTION	Genes involved in ECM-receptor interaction	87	AGRN(1), CD36(1), COL11A2(2), COL4A1(2), COL4A4(5), COL4A6(8), COL5A3(5), FNDC3A(2), GP1BA(1), GP5(1), HSPG2(5), ITGA1(1), ITGA11(2), ITGA2(3), ITGA5(1), ITGA7(1), ITGA8(6), ITGB4(1), LAMA1(11), LAMA2(15), LAMA3(5), LAMA5(3), LAMB1(4), LAMB2(8), LAMB3(3), LAMB4(8), LAMC3(3), RELN(16), TNC(12), TNXB(5), VWF(6)	1203307	147	58	147	43	32	72	17	12	14	<1.00e-11	<6.21e-10
9	SMOOTH_MUSCLE_CONTRACTION		138	ADCY2(4), ADCY3(1), ADCY4(1), ADCY5(4), ADCY8(7), ATP2A3(1), CAMK2A(1), CAMK2B(3), CAMK2D(1), CNN1(1), GRK4(2), GRK6(1), ITPR1(2), ITPR2(6), ITPR3(4), NOS3(1), PLCD1(1), PRKCA(2), PRKCE(1), RYR1(17), RYR2(44), RYR3(15), TNXB(5)	1026257	125	62	125	46	28	45	26	9	17	<1.00e-11	<6.21e-10
10	HSA04540_GAP_JUNCTION	Genes involved in gap junction	92	ADCY2(4), ADCY3(1), ADCY4(1), ADCY5(4), ADCY8(7), EGFR(7), GNA11(1), GNAS(3), GRM1(8), GUCY2C(3), ITPR1(2), ITPR2(6), ITPR3(4), KRAS(5), PDGFRB(3), PLCB1(5), PLCB4(3), PRKCA(2), SOS1(3), TUBA4A(1), TUBB4(1)	536396	74	49	69	28	19	16	18	7	14	1.11e-11	6.21e-10
11	HSA04730_LONG_TERM_ DEPRESSION	Genes involved in long-term depression	74	ARAF(1), BRAF(4), CACNA1A(1), GNA11(1), GNAS(3), GRIA1(3), GRM1(8), GUCY2C(3), ITPR1(2), ITPR2(6), ITPR3(4), KRAS(5), LYN(1), NOS3(1), PLA2G4A(3), PLCB1(5), PLCB4(3), PPP2R2A(2), PRKCA(2), RYR1(17)	485569	75	48	72	17	18	26	16	6	9	1.11e-11	6.21e-10
12	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	192	ACTN3(2), BRAF(4), COL11A2(2), COL4A1(2), COL4A4(5), COL4A6(8), COL5A3(5), DOCK1(4), EGFR(7), FLNA(1), FLNB(1), GRLF1(3), ITGA1(1), ITGA11(2), ITGA2(3), ITGA5(1), ITGA7(1), ITGA8(6), ITGB4(1), LAMA1(11), LAMA2(15), LAMA3(5), LAMA5(3), LAMB1(4), LAMB2(8), LAMB3(3), LAMB4(8), LAMC3(3), MET(2), MYL7(1), MYLK(4), PDGFRB(3), PIK3R5(2), PRKCA(2), PTK2(2), RELN(16), SOS1(3), TLN1(3), TLN2(3), TNC(12), TNXB(5), VWF(6)	1764566	183	72	181	53	45	81	26	14	17	1.69e-11	8.68e-10
13	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	34	BRAF(4), EGFR(7), EPHB2(1), ITPR1(2), ITPR2(6), ITPR3(4), PLCB1(5), PLCB4(3), SOS1(3)	158767	35	27	33	7	6	14	5	4	6	2.11e-10	9.98e-09
14	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	137	COL11A2(2), COL17A1(3), COL4A1(2), COL4A4(5), COL4A6(8), COL5A3(5), GJA10(2), GJB1(1), GJC2(1), ITGB4(1), KRT13(1), KRT14(1), KRT15(2), KRT3(1), KRT32(2), KRT6B(1), KRT72(2), KRT74(1), KRT75(1), KRT76(2), KRT82(2), KRT9(2), LAMA1(11), LAMA2(15), LAMA3(5), LAMA5(3), LAMB1(4), LAMB2(8), LAMB3(3), LAMB4(8), LAMC3(3), LMNB1(1), NES(1), RELN(16), TNC(12), TNXB(5), VWF(6)	1424137	149	61	149	42	35	72	21	9	12	4.74e-10	2.08e-08
15	HSA02010_ABC_TRANSPORTERS_ GENERAL	Genes involved in ABC transporters - general	44	ABCA10(4), ABCA13(14), ABCA3(4), ABCA4(3), ABCA6(3), ABCA7(2), ABCB1(3), ABCB5(11), ABCC1(1), ABCC10(1), ABCC12(5), ABCC2(1), ABCC3(3), ABCC5(2), ABCC8(5), ABCC9(5), ABCG4(2), ABCG5(2), ABCG8(1), TAP2(1)	530474	73	46	73	15	23	22	14	4	10	1.99e-09	8.19e-08
16	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	127	ABLIM1(1), ABLIM3(3), EPHA3(4), EPHA6(10), EPHB2(1), EPHB4(1), KRAS(5), MET(2), NFAT5(2), NFATC3(2), PLXNA1(4), PLXNA2(3), PLXNC1(3), PPP3CC(1), PTK2(2), RASA1(1), ROBO3(5), SEMA3G(3), SEMA4F(1), SEMA4G(1), SEMA6A(3), SEMA6B(1), SEMA6D(7), SEMA7A(1), SLIT1(6), SLIT3(6), SRGAP3(3)	647821	82	51	79	31	25	32	14	5	6	8.16e-09	3.14e-07
17	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	17	GRM1(8), PLCB1(5)	28560	13	12	13	1	5	1	3	0	4	1.07e-08	3.88e-07
18	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	23	APC(4), EPHB2(1), ITPR1(2), ITPR2(6), ITPR3(4), RHO(1), RYR1(17)	204800	35	25	35	8	3	19	5	4	4	3.68e-08	1.26e-06
19	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	131	ACTN3(2), ASH1L(3), CDK4(1), EPB41L1(2), EPB41L3(5), INADL(1), KRAS(5), LLGL1(1), LLGL2(2), MAGI1(3), MPDZ(2), MYH1(10), MYH10(3), MYH11(5), MYH13(7), MYH2(12), MYH4(8), MYH6(7), MYH7(5), MYH8(10), MYL7(1), PARD3(1), PPM1J(1), PPP2R2A(2), PRKCA(2), PRKCE(1), SPTAN1(3), SYMPK(2), YES1(3), ZAK(2)	1024252	112	59	108	29	30	39	24	7	12	7.21e-08	2.34e-06
20	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	34	APC(4), BRAF(4), EGFR(7), GNA11(1), ITPR1(2), ITPR2(6), ITPR3(4)	166461	28	23	26	5	2	13	5	5	3	3.29e-07	0.000010
21	GPCRDB_CLASS_C_METABOTROPIC_ GLUTAMATE_PHEROMONE		13	CASR(4), GRM1(8), GRM2(2)	38516	14	13	14	0	6	3	4	0	1	4.14e-07	0.000012
22	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	13	MYLK(4), PLCB1(5), PPP1R12B(2), PRKCA(2)	45453	13	12	13	4	5	4	0	0	4	6.30e-07	0.000018
23	ST_WNT_CA2_CYCLIC_ GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	19	CAMK2A(1), CAMK2B(3), CAMK2D(1), ITPR1(2), ITPR2(6), ITPR3(4), NFAT5(2), PDE6A(4), PDE6C(2)	153724	25	18	25	7	4	12	2	1	6	2.70e-06	0.000072
24	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	99	ADCY2(4), ADCY3(1), ADCY4(1), ADCY5(4), ADCY8(7), CAMK2A(1), CAMK2B(3), CAMK2D(1), CREB1(1), CREB3L3(1), CREBBP(2), DVL1(1), DVL3(3), FZD2(1), GNAS(3), KRAS(5), PLCB1(5), PLCB4(3), PRKCA(2), WNT7A(3)	527454	52	40	49	21	16	10	9	4	13	3.46e-06	0.000089
25	SA_DIACYLGLYCEROL_ SIGNALING	DAG (diacylglycerol) signaling activity	10	PDE1A(1), PDE1B(1), PLCB1(5)	15524	7	7	7	1	3	1	0	0	3	7.83e-06	0.00019
26	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	18	EGFR(7), PTPRB(8), RASA1(1), SOS1(3)	95272	19	17	17	6	3	5	8	2	1	8.27e-06	0.00020
27	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	11	COL4A1(2), COL4A3(1), COL4A4(5), COL4A6(8)	63053	16	11	16	11	3	7	3	1	2	0.000011	0.00026
28	HSA04320_DORSO_VENTRAL_ AXIS_FORMATION	Genes involved in dorso-ventral axis formation	28	BRAF(4), EGFR(7), KRAS(5), NOTCH1(2), NOTCH4(10), SOS1(3)	224770	31	26	26	8	7	10	10	4	0	0.000013	0.00028
29	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	21	GRIN2B(8), PPP3CC(1), PRKCA(2)	41825	11	10	11	2	8	2	1	0	0	0.000016	0.00034
30	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	6	PLCB1(5), PRKCA(2)	24016	7	7	7	2	4	0	0	0	3	0.000025	0.00051
31	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	7	PLCB1(5), PRKCA(2)	24755	7	7	7	3	4	0	0	0	3	0.000033	0.00064
32	GPCRDB_CLASS_B_SECRETIN_ LIKE		20	CALCR(4), ELTD1(4), EMR2(1), GLP2R(3), GPR64(2)	62256	14	14	14	3	3	5	2	0	4	0.000033	0.00064
33	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	12	ACE2(1), COL4A1(2), COL4A3(1), COL4A4(5), COL4A6(8), REN(1)	84575	18	13	18	12	4	7	4	1	2	0.000041	0.00076
34	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	16	C3(2), C6(2), C7(3), ITGAL(6), SELP(2)	65631	15	14	15	5	4	6	2	2	1	0.000052	0.00094
35	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	11	ITGAL(6), ITGAM(3), SELE(3), SELP(2)	65190	14	11	14	5	5	3	2	2	2	0.000059	0.0010
36	BLOOD_CLOTTING_CASCADE		21	F5(4), LPA(8), VWF(6)	107666	18	12	18	8	2	9	5	2	0	0.00011	0.0019
37	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	19	PLCB1(5), PPP1R12B(2), PRKCA(2), PTK2B(2)	59891	11	10	11	3	4	3	0	0	4	0.00013	0.0022
38	SIG_PIP3_SIGNALING_ IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	33	BCR(1), BTK(4), ITPR1(2), ITPR2(6), ITPR3(4), LYN(1), PTPRC(6), RPS6KA2(1)	208100	25	20	25	6	3	13	2	1	6	0.00016	0.0026
39	HSA04664_FC_EPSILON_ RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	74	BTK(4), INPP5D(1), KRAS(5), LAT(1), LYN(1), MAP2K4(1), MAP2K6(1), MS4A2(1), PIK3R5(2), PLA2G4A(3), PRKCA(2), PRKCE(1), SOS1(3)	192530	26	23	23	5	8	5	9	1	3	0.00018	0.0029
40	HSA04810_REGULATION_ OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	203	ACTN3(2), APC(4), APC2(1), ARAF(1), ARHGEF6(4), BRAF(4), CYFIP2(2), DOCK1(4), EGFR(7), FGD1(1), FGD3(3), GRLF1(3), ITGA1(1), ITGA11(2), ITGA2(3), ITGA5(1), ITGA7(1), ITGA8(6), ITGAD(5), ITGAE(1), ITGAL(6), ITGAM(3), ITGB4(1), KRAS(5), MYH10(3), MYL7(1), MYLK(4), NCKAP1L(4), PDGFRB(3), PIK3R5(2), PPP1R12B(2), PTK2(2), SOS1(3), TIAM2(5), WASF1(2), WASL(2)	1180715	104	57	99	25	23	35	24	12	10	0.00019	0.0029
41	SIG_CHEMOTAXIS	Genes related to chemotaxis	44	ARHGEF11(2), BTK(4), ITPR1(2), ITPR2(6), ITPR3(4), MYLK(4), RHO(1), WASF1(2), WASL(2)	249523	27	22	27	6	3	11	2	5	6	0.00022	0.0033
42	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	8	ITGAL(6), ITGAM(3), SELE(3)	64350	12	9	12	3	5	2	1	2	2	0.00022	0.0033
43	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	6	CPS1(8)	24645	8	8	8	2	2	2	2	1	1	0.00026	0.0038
44	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	7	RELN(16), VLDLR(1)	101722	17	14	17	5	5	8	1	1	2	0.00032	0.0044
45	HSA04670_LEUKOCYTE_ TRANSENDOTHELIAL_ MIGRATION	Genes involved in Leukocyte transendothelial migration	110	ACTN3(2), CDH5(1), CTNND1(3), CYBB(1), GRLF1(3), ITGAL(6), ITGAM(3), MYL7(1), PIK3R5(2), PRKCA(2), PTK2(2), PTK2B(2), RHOH(2)	290756	30	23	30	10	12	10	2	5	1	0.00039	0.0053
46	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	29	EGFR(7), GNAS(3), SOS1(3)	95897	13	12	11	5	2	2	7	2	0	0.00062	0.0081
47	HSA04370_VEGF_SIGNALING_ PATHWAY	Genes involved in VEGF signaling pathway	69	KRAS(5), MAPKAPK2(1), NFAT5(2), NFATC3(2), NOS3(1), PIK3R5(2), PLA2G4A(3), PPP3CC(1), PRKCA(2), PTK2(2)	171228	21	16	18	3	8	4	6	3	0	0.00062	0.0081
48	HSA04010_MAPK_SIGNALING_ PATHWAY	Genes involved in MAPK signaling pathway	248	ACVR1C(1), BRAF(4), CACNA1A(1), CACNA1C(8), CACNA1D(6), CACNA1E(19), CACNA1F(2), CACNA1G(4), CACNA1H(1), CACNA1I(1), CACNB2(1), CHUK(2), DDIT3(1), EGFR(7), FLNA(1), FLNB(1), KRAS(5), MAP2K4(1), MAP2K6(1), MAP3K12(1), MAP4K3(1), MAPK8IP1(1), MAPKAPK2(1), NF1(7), NTRK1(4), PDGFRB(3), PLA2G4A(3), PPP3CC(1), PRKCA(2), RASA1(1), RASA2(2), RASGRF2(4), RASGRP3(1), RPS6KA2(1), RPS6KA4(1), SOS1(3), TAOK2(6), ZAK(2)	1441671	112	62	105	34	26	31	30	9	16	0.00069	0.0089
49	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	21	ITGA1(1), PLA2G4A(3), PLCB1(5), PRKCA(2), PTK2(2)	87059	13	11	13	5	5	2	2	0	4	0.00079	0.0099
50	HSA04012_ERBB_SIGNALING_ PATHWAY	Genes involved in ErbB signaling pathway	85	ARAF(1), BRAF(4), CAMK2A(1), CAMK2B(3), CAMK2D(1), EGFR(7), KRAS(5), MAP2K4(1), PIK3R5(2), PRKCA(2), PTK2(2), SOS1(3), STAT5B(1)	311173	33	28	28	7	11	7	9	4	2	0.00081	0.0100
51	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	12	CSF1R(2), EGFR(7), MET(2), PRKCA(2)	78720	13	12	11	6	3	2	5	2	1	0.00093	0.011
52	HSA00061_FATTY_ACID_ BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	6	ACACA(2), ACACB(4), OLAH(2)	36152	8	8	8	2	1	2	2	2	1	0.00093	0.011
53	HSA00680_METHANE_ METABOLISM	Genes involved in methane metabolism	10	TPO(6)	22127	6	6	6	2	0	4	0	2	0	0.0011	0.012
54	HSA00940_PHENYLPROPANOID_ BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	7	TPO(6)	22127	6	6	6	2	0	4	0	2	0	0.0011	0.012
55	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	7	EGFR(7)	36055	7	7	5	1	0	2	3	2	0	0.0011	0.012
56	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	10	CR1(3), ITGAL(6), PTPRC(6)	90809	15	14	15	1	6	4	2	1	2	0.0011	0.012
57	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	11	GNAS(3), PRKCA(2)	17733	5	5	5	3	3	0	2	0	0	0.0013	0.014
58	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	8	CREB1(1), PTK2B(2), SOS1(3)	20216	6	6	6	1	1	2	2	1	0	0.0014	0.015
59	HSA04080_NEUROACTIVE_ LIGAND_RECEPTOR_ INTERACTION	Genes involved in neuroactive ligand-receptor interaction	238	AVPR2(1), CALCR(4), CTSG(1), F2RL2(3), GABBR2(4), GABRA3(2), GABRG3(2), GABRP(1), GABRR1(2), GLP2R(3), GPR156(3), GRIA1(3), GRIK5(1), GRIN2B(8), GRM1(8), GRM2(2), LEPR(1), LTB4R(1), NPY1R(1), NTSR2(1), PARD3(1), PRSS1(2), PTH2R(4), RXFP1(3), THRB(1), TRPV1(1)	703078	64	40	64	20	19	23	15	3	4	0.0016	0.017
60	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	10	AKAP9(4), PRKCE(1)	16281	5	5	5	1	1	1	3	0	0	0.0017	0.017
61	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	11	ITGAL(6), PTPRC(6)	71397	12	11	12	1	5	3	1	1	2	0.0017	0.017
62	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	11	ITGAL(6), PTPRC(6)	71397	12	11	12	1	5	3	1	1	2	0.0017	0.017
63	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	15	PLCB1(5), PRKCA(2)	53337	7	7	7	3	4	0	0	0	3	0.0019	0.019
64	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	7	ATM(5)	16555	5	5	5	0	1	1	1	1	1	0.0021	0.020
65	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	20	IL16(5)	22430	5	5	5	0	0	4	0	1	0	0.0023	0.021
66	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	9	ITGAL(6), SELE(3)	58230	9	7	9	0	3	1	1	2	2	0.0023	0.021
67	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	10	ITGAL(6)	32947	6	5	6	0	3	0	1	1	1	0.0024	0.023
68	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	26	CAMK2A(1), CAMK2B(3), CAMK2D(1), CREB1(1), GNAS(3), PRKCA(2), SOS1(3)	108100	14	11	14	6	6	1	5	1	1	0.0026	0.024
69	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	35	DOCK1(4), ITGA1(1), MET(2), PTK2(2), PTK2B(2), RASA1(1), SOS1(3)	108477	15	12	15	6	3	3	6	0	3	0.0027	0.024
70	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	18	NTRK1(4), WASF1(2), WASF3(1), WASL(2)	113289	9	9	8	1	0	2	0	3	4	0.0027	0.024
71	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	37	CAMK2A(1), CAMK2B(3), CAMK2D(1), GNA11(1), JAK2(1), MYLK(4), PRKCA(2), PTK2B(2), SOS1(3), STAT1(2)	149981	20	15	20	6	7	8	4	0	1	0.0033	0.029
72	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	7	AKAP13(5)	19560	5	5	5	0	1	1	1	0	2	0.0034	0.029
73	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	25	ATM(5), CDK4(1), CDK6(1), SKP2(2)	50502	9	9	9	0	2	3	1	2	1	0.0035	0.030
74	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	19	ABCB1(3), ATM(5)	42724	8	8	8	2	2	1	2	1	2	0.0038	0.031
75	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	16	ADAM12(2), EGFR(7), PRKCA(2)	68471	11	10	9	2	3	3	3	2	0	0.0038	0.031
76	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	22	PLCB1(5), PRKCA(2), PTK2(2)	63734	9	9	9	3	4	1	1	0	3	0.0038	0.031
77	PROSTAGLANDIN_AND_ LEUKOTRIENE_METABOLISM		31	PLA2G4A(3), TPO(6)	53062	9	8	9	2	1	5	1	2	0	0.0040	0.032
78	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	11	GNAS(3)	8640	3	3	3	2	1	0	2	0	0	0.0042	0.033
79	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	6	C3(2), C6(2), C7(3), C9(1)	51796	8	8	8	5	1	6	0	1	0	0.0047	0.037
80	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	16	ATM(5), CDK4(1)	25525	6	6	6	0	1	2	1	1	1	0.0048	0.037
81	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	21	GNAS(3), PLCB1(5), PPP1R12B(2), PRKCA(2), PTK2(2)	124467	14	13	14	6	5	2	3	0	4	0.0052	0.040
82	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	23	PIGG(1), PIGO(2)	12351	3	3	3	0	0	0	3	0	0	0.0056	0.042
83	SIG_BCR_SIGNALING_ PATHWAY	Members of the BCR signaling pathway	46	BCR(1), BLNK(1), BTK(4), CD22(2), INPP5D(1), ITPR1(2), ITPR2(6), ITPR3(4), LYN(1), PPP3CC(1), PTPRC(6), SOS1(3)	343782	32	26	32	10	5	14	5	1	7	0.0060	0.044
84	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	24	POLA2(1), POLD1(2), POLQ(3), REV3L(3)	77996	9	8	9	2	0	3	1	2	3	0.0061	0.045
85	METHANE_METABOLISM		13	TPO(6)	33764	6	6	6	2	0	4	0	2	0	0.0072	0.051
86	STILBENE_COUMARINE_ AND_LIGNIN_BIOSYNTHESIS		10	TPO(6)	33764	6	6	6	2	0	4	0	2	0	0.0072	0.051
87	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	34	CREB1(1), GNAS(3), NFATC3(2), PPP3CC(1), PRKCA(2)	77814	9	7	9	4	4	0	3	2	0	0.0074	0.052
88	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	22	COL4A1(2), COL4A3(1), COL4A4(5), COL4A6(8), F5(4)	154610	20	14	20	16	4	9	4	1	2	0.0074	0.052
89	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	12	WASF1(2), WASL(2)	50763	4	4	4	0	0	0	0	3	1	0.0079	0.055
90	HSA04650_NATURAL_ KILLER_CELL_MEDIATED_ CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	126	ARAF(1), BRAF(4), HCST(1), IFNA16(2), ITGAL(6), KRAS(5), LAT(1), NFAT5(2), NFATC3(2), PIK3R5(2), PPP3CC(1), PRKCA(2), PTK2B(2), SOS1(3)	396255	34	27	31	5	14	8	7	4	1	0.0080	0.055
91	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	12	NTRK1(4), PRKCA(2), SOS1(3)	55428	9	8	8	3	3	2	2	0	2	0.0086	0.058
92	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	13	PTK2(2), PTK2B(2), TERT(1)	24506	5	5	5	1	0	4	1	0	0	0.0090	0.060
93	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	21	CREBBP(2), GNAS(3), PTPRC(6)	68826	11	11	11	4	3	4	2	0	2	0.0094	0.062
94	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	21	CREBBP(2), GNAS(3), PTPRC(6)	68826	11	11	11	4	3	4	2	0	2	0.0094	0.062
95	TYROSINE_METABOLISM		32	ADH1B(4), ADH6(2), ALDH3A1(1), AOC2(1), DDC(2), TAT(1), TPO(6)	142384	17	16	17	4	4	8	1	2	2	0.010	0.067
96	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	17	PRKCA(2), PTK2B(2)	13893	4	4	4	1	2	2	0	0	0	0.011	0.071
97	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	4	PRKCA(2), PTK2B(2)	13893	4	4	4	1	2	2	0	0	0	0.011	0.071
98	G_PROTEIN_SIGNALING		92	ADCY2(4), ADCY3(1), ADCY4(1), ADCY5(4), ADCY8(7), AKAP11(2), AKAP9(4), GNA11(1), ITPR1(2), KRAS(5), PDE1A(1), PDE1B(1), PDE4C(2), PDE7B(1), PDE8A(1), PPP3CC(1), PRKCA(2), PRKCE(1), PRKD3(1)	464901	42	30	39	16	12	11	11	3	5	0.011	0.071
99	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	19	AMPH(3), PICALM(2), PPP3CC(1), SYNJ2(1)	43532	7	6	7	2	4	1	2	0	0	0.012	0.075
100	ST_PHOSPHOINOSITIDE_ 3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	33	BTK(4), INPP5D(1), RPS6KA2(1), SOS1(3)	58818	9	9	9	1	1	3	3	0	2	0.012	0.075
101	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	5	EGFR(7)	58135	7	7	5	1	0	2	3	2	0	0.013	0.078
102	RIBOFLAVIN_METABOLISM		10	ACP5(2), ACPP(1), ENPP3(2)	24595	5	5	5	0	3	2	0	0	0	0.016	0.094
103	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	12	BFAR(1), BRAF(4), CREB1(1)	45110	6	6	6	0	1	3	0	2	0	0.017	0.099
104	SIG_REGULATION_OF_ THE_ACTIN_CYTOSKELETON_ BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	35	ACTG2(2), FLNA(1), MYH2(12), MYLK(4), RHO(1), WASF1(2), WASL(2)	263099	24	22	24	4	6	9	3	5	1	0.017	0.099
105	NITROGEN_METABOLISM		21	CA9(1), CPS1(8)	61075	9	9	9	2	2	2	3	1	1	0.017	0.099
106	HSA04514_CELL_ADHESION_ MOLECULES	Genes involved in cell adhesion molecules (CAMs)	130	CD22(2), CDH1(1), CDH5(1), CNTN1(6), ITGA8(6), ITGAL(6), ITGAM(3), MAG(2), NLGN2(1), NRCAM(6), PTPRC(6), PTPRF(2), PTPRM(4), SELE(3), SELP(2), VCAN(9)	719993	60	37	60	22	19	20	9	5	7	0.017	0.099
107	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	6	GNAS(3)	13639	3	3	3	2	1	0	2	0	0	0.018	0.10
108	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	28	CXCR3(1), IL12RB2(2)	17139	3	2	3	1	1	0	0	1	1	0.019	0.11
109	ST_INTERFERON_GAMMA_ PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	9	JAK1(1), JAK2(1), PTPRU(3), STAT1(2)	48570	7	7	7	1	1	5	0	1	0	0.020	0.11
110	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	17	GNAS(3), PRKAG2(1)	20280	4	4	4	2	2	0	2	0	0	0.020	0.11
111	PANTOTHENATE_AND_ COA_BIOSYNTHESIS		12	DPYS(3), ENPP3(2), PANK3(1), PANK4(1)	47188	7	7	7	2	3	3	0	1	0	0.021	0.12
112	ST_TYPE_I_INTERFERON_ PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	8	JAK1(1), PTPRU(3), STAT1(2), STAT2(2)	54517	8	8	8	1	2	4	0	1	1	0.022	0.12
113	DNA_POLYMERASE		7	POLD1(2), POLQ(3)	38945	5	4	5	1	0	1	1	1	2	0.023	0.13
114	HSA00950_ALKALOID_ BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	5	DDC(2), TAT(1)	11696	3	3	3	1	1	1	0	0	1	0.024	0.13
115	ST_INTEGRIN_SIGNALING_ PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	78	ARHGEF6(4), BRAF(4), DOCK1(4), EPHB2(1), GRLF1(3), ITGA1(1), ITGA11(2), ITGA2(3), ITGA5(1), ITGA7(1), ITGA8(6), MAP2K4(1), MAPK8IP1(1), MYLK(4), PTK2(2), RHO(1), SOS1(3), TLN1(3), TLN2(3)	553563	48	33	48	12	14	19	7	2	6	0.026	0.14
116	INTEGRIN_MEDIATED_ CELL_ADHESION_KEGG		90	CAPN11(3), CAPN3(1), CAPN5(2), DOCK1(4), ITGA11(2), ITGA2(3), ITGA5(1), ITGA7(1), ITGA8(6), ITGAD(5), ITGAE(1), ITGAL(6), ITGAM(3), ITGB4(1), MAP2K6(1), PTK2(2), RHO(1), SORBS1(3), SOS1(3), TLN1(3)	639966	52	33	52	15	18	15	10	3	6	0.027	0.14
117	BILE_ACID_BIOSYNTHESIS		27	ADH1B(4), ADH6(2), ALDH3A1(1), HADHB(3)	67844	10	10	10	1	4	3	2	0	1	0.028	0.15
118	HSA00280_VALINE_ LEUCINE_AND_ISOLEUCINE_ DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	44	ALDH3A1(1), BCAT2(2), DBT(1), DLD(2), EHHADH(1), HADHB(3), HSD17B4(2), MCCC2(2)	128852	14	14	14	2	4	4	4	2	0	0.029	0.15
119	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	4	PLCD1(1), PRKCA(2)	21033	3	3	3	1	3	0	0	0	0	0.029	0.15
120	HSA00620_PYRUVATE_ METABOLISM	Genes involved in pyruvate metabolism	42	ACACA(2), ACACB(4), ACSS1(1), ALDH3A1(1), DLAT(1), DLD(2), GRHPR(1), HAGH(1), LDHC(1), PC(1)	196090	15	14	15	6	4	2	6	3	0	0.030	0.15
121	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	15	NTRK1(4), SOS1(3)	50055	7	7	6	2	1	2	2	0	2	0.030	0.15
122	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	52	CAMK4(3), CREBBP(2), ELSPBP1(2), HAND1(1), MYH2(12), NFATC3(2), PPP3CC(1)	234247	23	20	23	4	9	8	3	2	1	0.030	0.15
123	UREA_CYCLE_AND_METABOLISM_ OF_AMINO_GROUPS		20	CPS1(8)	54289	8	8	8	2	2	2	2	1	1	0.030	0.15
124	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	15	CXCR3(1), IL12RB2(2), JAK2(1)	25504	4	2	4	1	1	1	0	1	1	0.032	0.16
125	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	9	JAK1(1), JAK2(1), PIAS1(1), PTPRU(3)	43100	6	6	6	0	1	4	0	1	0	0.034	0.17
126	GLYCEROLIPID_METABOLISM		45	ADH1B(4), ADH6(2), ALDH3A1(1), DGAT1(2), PNLIP(4), PNLIPRP1(3), PNLIPRP2(3)	217941	19	16	19	6	5	7	2	0	5	0.035	0.17
127	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	33	EGFR(7), MAP2K4(1), PRKCA(2), PTK2(2), PTK2B(2), SOS1(3)	164287	17	15	15	4	3	5	6	2	1	0.036	0.17
128	HSA04520_ADHERENS_ JUNCTION	Genes involved in adherens junction	75	ACTN3(2), ACVR1C(1), CDH1(1), CREBBP(2), CTNND1(3), EGFR(7), INSR(1), MET(2), PARD3(1), PTPRB(8), PTPRF(2), PTPRJ(2), PTPRM(4), SORBS1(3), WASF1(2), WASF3(1), WASL(2), YES1(3)	672014	47	37	45	10	12	10	12	7	6	0.037	0.18
129	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	22	BTK(4), LYN(1), PFKP(1), PRKCE(1)	75538	7	7	7	1	0	1	3	1	2	0.037	0.18
130	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	17	IL12RB2(2)	14606	2	1	2	1	0	0	0	1	1	0.038	0.18
131	STARCH_AND_SUCROSE_ METABOLISM		44	AGL(3), ENPP3(2), GANAB(1), GCK(2), GPI(2), GYS2(2), HK1(1), MGAM(6), UGT2B15(1)	241786	20	17	20	5	5	12	1	2	0	0.039	0.18
132	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	10	PTPRC(6)	40162	6	6	6	1	2	3	0	0	1	0.039	0.18
133	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	10	ITGA1(1), LYN(1), SELP(2)	25178	4	4	4	4	0	1	2	0	1	0.040	0.18
134	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	20	CXCR3(1), IL12RB2(2), JAK2(1), MAP2K6(1)	35824	5	3	5	1	1	2	0	1	1	0.041	0.19
135	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	10	EGFR(7), NCOR2(3), THRB(1)	122600	11	11	9	2	2	3	3	3	0	0.041	0.19
136	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	21	CD5(2), TLR9(3)	34982	5	4	5	0	0	2	1	1	1	0.043	0.19
137	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	28	LMNB1(1), MADD(4), MAP2K4(1), PRKDC(5), SPTAN1(3)	268750	14	13	14	3	3	0	3	4	4	0.043	0.19
138	HSA04060_CYTOKINE_ CYTOKINE_RECEPTOR_ INTERACTION	Genes involved in cytokine-cytokine receptor interaction	252	CSF1R(2), CXCR3(1), EGFR(7), FLT4(5), IFNA16(2), IL10RA(1), IL12RB2(2), IL18RAP(2), IL19(1), IL21R(2), IL28B(1), IL5RA(1), INHBC(1), LEPR(1), LTB(1), MET(2), PDGFRB(3), PLEKHO2(1), TNFRSF1B(1), TPO(6), TSLP(1), XCL1(1)	676136	45	36	43	17	8	13	11	8	5	0.044	0.19
139	HSA00910_NITROGEN_ METABOLISM	Genes involved in nitrogen metabolism	24	CA9(1), CPS1(8)	72575	9	9	9	3	2	2	3	1	1	0.044	0.19
140	HSA04150_MTOR_SIGNALING_ PATHWAY	Genes involved in mTOR signaling pathway	44	BRAF(4), EIF4B(2), PIK3R5(2), RICTOR(3), RPS6KA2(1), ULK2(2)	117383	14	12	14	2	4	6	2	1	1	0.044	0.19
141	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	11	JAK1(1), JAK2(1), PTPRU(3)	41370	5	5	5	0	0	4	0	1	0	0.046	0.20
142	HSA00062_FATTY_ACID_ ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	10	HADHB(3), HSD17B4(2)	42076	5	5	5	0	3	0	1	1	0	0.046	0.20
143	GLUTAMATE_METABOLISM		24	CAD(3), CPS1(8)	94860	11	11	11	3	2	3	4	1	1	0.047	0.20
144	HSA04660_T_CELL_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in T cell receptor signaling pathway	93	CDK4(1), CHUK(2), GRAP2(1), KRAS(5), LAT(1), NFAT5(2), NFATC3(2), PIK3R5(2), PPP3CC(1), PTPRC(6), SOS1(3)	287290	26	22	23	5	8	6	7	2	3	0.047	0.20
145	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	8	JAK1(1), STAT1(2), STAT2(2)	39605	5	5	5	1	2	1	0	1	1	0.048	0.20
146	INOSITOL_PHOSPHATE_ METABOLISM		23	PIK3C2A(1), PIK3C2B(2), PLCB1(5), PLCB4(3), PLCD1(1)	137507	12	10	12	2	5	2	1	1	3	0.053	0.22
147	ST_DIFFERENTIATION_ PATHWAY_IN_PC12_ CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	42	BRAF(4), CREB1(1), CREBBP(2), MAP1B(4), MAP2K4(1), MAPK8IP1(1), NTRK1(4), OPN1LW(1)	222330	18	16	17	5	5	7	0	2	4	0.054	0.23
148	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	9	GPI(2), HK1(1), PGK1(2)	33360	5	5	5	2	1	3	0	0	1	0.056	0.23
149	PYRUVATE_METABOLISM		37	ACACA(2), ALDH3A1(1), DLAT(1), DLD(2), GRHPR(1), HAGH(1), LDHC(1), PC(1)	137890	10	10	10	4	2	1	5	2	0	0.058	0.24
150	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	34	BLNK(1), BTK(4), LYN(1), NFATC3(2), PPP3CC(1), PRKCA(2), SOS1(3)	160331	14	12	14	4	4	1	6	1	2	0.058	0.24
151	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	12	GABRA3(2)	9560	2	2	2	2	0	2	0	0	0	0.060	0.24
152	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	26	EGFR(7), JAK1(1), MAP2K4(1), PRKCA(2), RASA1(1), SOS1(3), STAT1(2)	213720	17	14	15	6	4	3	6	3	1	0.064	0.26
153	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	18	NFATC3(2), PPP3CC(1), PRKCA(2)	46745	5	4	5	1	3	0	1	1	0	0.065	0.26
154	HSA04640_HEMATOPOIETIC_ CELL_LINEAGE	Genes involved in hematopoietic cell lineage	86	CD1B(2), CD1C(3), CD1E(1), CD22(2), CD36(1), CD5(2), CR1(3), CSF1R(2), GP1BA(1), GP5(1), IL5RA(1), ITGA1(1), ITGA2(3), ITGA5(1), ITGAM(3), TPO(6)	387556	33	24	33	15	6	17	4	2	4	0.066	0.26
155	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	27	ITPR1(2), ITPR2(6), ITPR3(4)	144562	12	11	12	4	1	7	0	1	3	0.066	0.26
156	HSA00592_ALPHA_LINOLENIC_ ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	15	PLA2G4A(3)	13658	3	2	3	0	1	1	1	0	0	0.067	0.27
157	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	37	BTK(4), LYN(1), MAP2K4(1), NFATC3(2), PLA2G4A(3), PPP3CC(1), SOS1(3)	181074	15	10	15	3	3	2	6	1	3	0.070	0.27
158	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	13	BLVRB(1), IL10RA(1), JAK1(1), STAT1(2)	40569	5	5	5	1	1	2	0	1	1	0.072	0.28
159	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	19	ATM(5), RAD51(1)	50546	6	6	6	0	1	1	2	1	1	0.072	0.28
160	HSA04070_PHOSPHATIDYLINOSITOL_ SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	73	INPP5B(2), INPP5D(1), ITPR1(2), ITPR2(6), ITPR3(4), PIK3C2A(1), PIK3C2B(2), PIK3R5(2), PLCB1(5), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(2), PRKCA(2), SYNJ2(1)	491680	36	29	36	10	11	13	3	2	7	0.073	0.28
161	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	16	CHUK(2), CREBBP(2), TNFRSF1B(1)	69077	5	5	5	1	1	1	0	0	3	0.074	0.28
162	HSA00561_GLYCEROLIPID_ METABOLISM	Genes involved in glycerolipid metabolism	55	ADH1B(4), ADH6(2), ALDH3A1(1), DGAT1(2), GPAM(1), PNLIP(4), PNLIPRP1(3), PNLIPRP2(3)	247450	20	17	20	6	5	7	3	0	5	0.076	0.29
163	HSA00710_CARBON_ FIXATION	Genes involved in carbon fixation	23	PGK1(2), TKTL1(3)	56254	5	5	5	0	1	0	2	0	2	0.076	0.29
164	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	14	CHUK(2)	24142	2	2	2	0	0	0	0	0	2	0.076	0.29
165	1_AND_2_METHYLNAPHTHALENE_ DEGRADATION		7	ADH1B(4), ADH6(2)	48028	6	6	6	0	2	3	0	0	1	0.077	0.29
166	ST_FAS_SIGNALING_ PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	59	BFAR(1), BTK(4), CAD(3), CASP10(2), EGFR(7), EPHB2(1), FAIM2(1), MAP2K4(1), MAPK8IP1(1), MET(2), NFAT5(2), PTPN13(3), TPX2(1)	378946	29	26	27	6	5	8	10	3	3	0.078	0.29
167	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	22	ATM(5), PRKDC(5)	120287	10	9	10	2	3	1	2	2	2	0.078	0.29
168	HSA00512_O_GLYCAN_ BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	30	GALNT1(3), GALNT7(1), GALNT8(1), GALNTL2(2), OGT(2)	137340	9	9	9	4	1	3	1	3	1	0.081	0.30
169	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	22	JAK2(1), PRKCA(2), RASA1(1), SOS1(3), STAT1(2), STAT5B(1)	96118	10	9	10	5	5	2	3	0	0	0.084	0.31
170	HSA00330_ARGININE_ AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	34	CPS1(8), NOS3(1)	92789	9	9	9	2	2	2	2	2	1	0.086	0.31
171	PHENYLALANINE_METABOLISM		22	ALDH3A1(1), AOC2(1), DDC(2), TAT(1), TPO(6)	105993	11	11	11	4	2	5	1	2	1	0.087	0.31
172	HSA00071_FATTY_ACID_ METABOLISM	Genes involved in fatty acid metabolism	47	ACSL3(1), ACSL5(1), ADH1B(4), ADH6(2), ALDH3A1(1), EHHADH(1), GCDH(1), HADHB(3), HSD17B4(2)	171707	16	15	16	2	7	4	2	1	2	0.088	0.32
173	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	27	CASP10(2), LMNB1(1), MAP2K4(1), PRKDC(5), PTPN13(3), SPTAN1(3)	204945	15	14	15	4	5	1	4	2	3	0.093	0.33
174	HSA00120_BILE_ACID_ BIOSYNTHESIS	Genes involved in bile acid biosynthesis	38	ADH1B(4), ADH6(2), ALDH3A1(1), HADHB(3)	87384	10	10	10	1	4	3	2	0	1	0.095	0.34
175	STATIN_PATHWAY_PHARMGKB		18	DGAT1(2), HMGCR(1), LDLR(2), LRP1(6)	129836	11	11	9	7	2	4	5	0	0	0.096	0.34
176	ARGININE_AND_PROLINE_ METABOLISM		43	ALDH3A1(1), AOC2(1), CPS1(8), NOS3(1)	123845	11	11	11	4	3	2	3	2	1	0.096	0.34
177	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	17	GNAS(3), NOS3(1)	46869	4	4	4	2	1	0	2	1	0	0.096	0.34
178	HSA04310_WNT_SIGNALING_ PATHWAY	Genes involved in Wnt signaling pathway	146	APC(4), APC2(1), AXIN1(1), CAMK2A(1), CAMK2B(3), CAMK2D(1), CHD8(3), CREBBP(2), CTBP2(1), DVL1(1), DVL3(3), FZD2(1), LRP5(2), LRP6(1), NFAT5(2), NFATC3(2), PLCB1(5), PLCB4(3), PPP2R2A(2), PPP3CC(1), PRKCA(2), SENP2(1), WNT7A(3)	720624	46	35	46	6	12	14	7	3	10	0.100	0.34
179	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	6	ABCB1(3), ABCC1(1), ABCC3(3)	59981	7	7	7	4	2	2	1	1	1	0.10	0.34
180	HSA00641_3_CHLOROACRYLIC_ ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	15	ADH1B(4), ADH6(2), ALDH3A1(1)	54441	7	7	7	1	2	3	1	0	1	0.10	0.34
181	ST_DICTYOSTELIUM_ DISCOIDEUM_CAMP_ CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	32	ITPR1(2), ITPR2(6), ITPR3(4), RIPK3(1)	174410	13	12	13	5	2	7	0	1	3	0.10	0.34
182	GALACTOSE_METABOLISM		24	GANAB(1), GCK(2), HK1(1), MGAM(6), PFKP(1)	141663	11	11	11	4	2	5	1	3	0	0.10	0.34
183	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	50	CD36(1), CREBBP(2), EHHADH(1), HSD17B4(2), MRPL11(1), NCOR1(1), NCOR2(3), NR1H3(2), PRKCA(2), STAT5B(1)	193289	16	14	16	5	5	8	0	2	1	0.10	0.35
184	ST_WNT_BETA_CATENIN_ PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	31	ANKRD6(1), APC(4), AXIN1(1), DVL1(1), FSTL1(4), LRP1(6), SENP2(1)	267842	18	15	14	4	5	3	8	1	1	0.10	0.35
185	ST_INTERLEUKIN_4_ PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	26	INPP5D(1), JAK1(1), JAK2(1), SOS1(3)	50814	6	6	6	1	1	2	2	1	0	0.10	0.35
186	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	9	GABRA3(2), PRKCE(1)	19481	3	3	3	2	0	2	1	0	0	0.10	0.35
187	HSA04910_INSULIN_ SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	131	ACACA(2), ACACB(4), ARAF(1), BRAF(4), GCK(2), GYS2(2), INPP5D(1), INSR(1), IRS4(7), KRAS(5), LIPE(1), PFKP(1), PIK3R5(2), PRKAG2(1), PTPRF(2), SORBS1(3), SOS1(3)	732488	42	34	39	14	11	12	10	8	1	0.11	0.35
188	HSA00562_INOSITOL_ PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	47	INPP5B(2), PLCB1(5), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(2), SYNJ2(1)	221370	16	14	16	3	6	4	2	0	4	0.11	0.35
189	IFNGPATHWAY	IFN gamma signaling pathway	6	JAK1(1), JAK2(1), STAT1(2)	33658	4	4	4	1	1	2	0	1	0	0.11	0.35
190	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	13	CREB1(1), NOS3(1)	41159	2	2	2	0	0	0	0	2	0	0.11	0.35
191	HSA00591_LINOLEIC_ ACID_METABOLISM	Genes involved in linoleic acid metabolism	31	CYP2C19(1), CYP2E1(1), CYP3A7(3), PLA2G4A(3)	66796	8	7	8	2	2	4	1	0	1	0.11	0.35
192	HSA04610_COMPLEMENT_ AND_COAGULATION_ CASCADES	Genes involved in complement and coagulation cascades	69	C1QA(1), C1QC(1), C2(2), C3(2), C6(2), C7(3), C8B(2), C9(1), CFB(1), CFI(3), CR1(3), F13A1(5), F5(4), SERPIND1(1), VWF(6)	480174	37	28	37	13	8	18	6	3	2	0.11	0.35
193	HSA00251_GLUTAMATE_ METABOLISM	Genes involved in glutamate metabolism	31	ADC(1), CAD(3), CPS1(8), EARS2(2), GFPT2(2)	187069	16	16	16	4	4	4	5	1	2	0.11	0.35
194	NICOTINATE_AND_NICOTINAMIDE_ METABOLISM		13	ENPP3(2), NNMT(1), NNT(1), NT5E(1)	56159	5	5	5	2	2	0	2	1	0	0.12	0.37
195	STEROID_BIOSYNTHESIS		9	HSD17B4(2)	19236	2	2	2	0	1	0	0	1	0	0.12	0.37
196	ST_GRANULE_CELL_ SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	25	APC(4), CREB1(1), EPHB2(1), MAP2K4(1), MAPK8IP1(1)	90806	8	7	8	1	1	3	1	2	1	0.12	0.37
197	VALINE_LEUCINE_AND_ ISOLEUCINE_BIOSYNTHESIS		7	LARS(4), LARS2(1)	43867	5	5	5	1	1	2	1	1	0	0.12	0.37
198	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	6	LDLR(2)	10336	2	2	2	1	0	2	0	0	0	0.12	0.38
199	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	12	F13A1(5)	37781	5	5	5	1	1	3	1	0	0	0.12	0.38
200	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	16	CREBBP(2), JAK1(1), PTK2B(2), STAT5B(1)	62452	6	6	6	1	1	3	0	1	1	0.13	0.39
201	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	32	CHUK(2), MAP2K4(1), MAP2K6(1), TLR9(3), TOLLIP(1)	173736	8	7	8	0	1	1	1	1	4	0.13	0.39
202	HSA04330_NOTCH_SIGNALING_ PATHWAY	Genes involved in Notch signaling pathway	43	ADAM17(2), CREBBP(2), CTBP2(1), DLL3(1), DVL1(1), DVL3(3), HDAC2(1), MAML1(1), NCOR2(3), NOTCH1(2), NOTCH4(10), NUMB(1), PSENEN(1), RBPJL(2)	387670	31	23	31	8	9	12	7	1	2	0.13	0.39
203	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	43	CHUK(2), EGFR(7), MAP2K4(1), MAP2K6(1), PRKCA(2), PRKCE(1), TNFRSF1B(1)	195792	15	14	13	3	3	3	4	2	3	0.13	0.39
204	HSA04662_B_CELL_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in B cell receptor signaling pathway	63	BLNK(1), BTK(4), CD22(2), CHUK(2), INPP5D(1), KRAS(5), LYN(1), NFAT5(2), NFATC3(2), PIK3R5(2), PPP3CC(1), RASGRP3(1)	349881	24	19	21	5	5	5	7	2	5	0.13	0.39
205	HSA00350_TYROSINE_ METABOLISM	Genes involved in tyrosine metabolism	56	ADH1B(4), ADH6(2), ALDH3A1(1), AOC2(1), DDC(2), TAT(1), TPO(6)	199778	17	16	17	6	4	8	1	2	2	0.13	0.39
206	GAMMA_HEXACHLOROCYCLOHEXANE_ DEGRADATION		31	ACP5(2), ACPP(1), ALPP(1), CYP2A13(2), CYP2C19(1), CYP2E1(1), CYP3A7(3), CYP4F8(2)	168981	13	12	13	2	3	9	0	0	1	0.13	0.40
207	HSA01040_POLYUNSATURATED_ FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	13	HSD17B12(1)	2457	1	1	1	0	0	1	0	0	0	0.13	0.40
208	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	13	CREB1(1), CREBBP(2)	38623	3	3	3	1	0	1	0	1	1	0.13	0.40
209	CELL_CYCLE_KEGG		82	ATM(5), CDH1(1), CDK4(1), HDAC2(1), HDAC5(1), MCM2(1), ORC2L(1), ORC3L(2), PLK1(1), PRKDC(5), RBL1(1), SKP2(2), TBC1D8(2)	293607	24	21	24	5	8	7	4	3	2	0.13	0.40
210	HSA00740_RIBOFLAVIN_ METABOLISM	Genes involved in riboflavin metabolism	16	ACP5(2), ACP6(1), ACPP(1), ENPP3(2)	56508	6	6	6	0	3	3	0	0	0	0.13	0.40
211	HSA00052_GALACTOSE_ METABOLISM	Genes involved in galactose metabolism	32	GCK(2), HK1(1), MGAM(6), PFKP(1)	138638	10	10	10	4	2	4	1	3	0	0.14	0.40
212	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	9	CHUK(2)	37195	2	2	2	0	0	0	0	0	2	0.14	0.40
213	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	7	CREM(1), GNAS(3)	30169	4	4	4	2	1	1	2	0	0	0.14	0.40
214	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	6	LDLR(2), NR1H3(2)	34212	4	4	4	2	0	4	0	0	0	0.14	0.41
215	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	12	CASP10(2)	24240	2	2	2	0	0	0	1	1	0	0.15	0.41
216	HSA00360_PHENYLALANINE_ METABOLISM	Genes involved in phenylalanine metabolism	27	ALDH3A1(1), AOC2(1), DDC(2), TAT(1), TPO(6)	119803	11	11	11	6	2	5	1	2	1	0.15	0.41
217	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	7	PLCB1(5)	109355	5	5	5	1	2	0	0	0	3	0.15	0.41
218	1_2_DICHLOROETHANE_ DEGRADATION		8	ALDH3A1(1)	6413	1	1	1	1	0	0	1	0	0	0.15	0.41
219	ASCORBATE_AND_ALDARATE_ METABOLISM		8	ALDH3A1(1)	6413	1	1	1	1	0	0	1	0	0	0.15	0.41
220	HSA00053_ASCORBATE_ AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	9	ALDH3A1(1)	6413	1	1	1	1	0	0	1	0	0	0.15	0.41
221	HSA04920_ADIPOCYTOKINE_ SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	71	ACACB(4), ACSL3(1), ACSL5(1), ADIPOR1(1), CAMKK1(1), CD36(1), CHUK(2), IRS4(7), JAK1(1), JAK2(1), LEPR(1), PRKAG2(1), TNFRSF1B(1)	360476	23	21	23	4	6	7	2	4	4	0.16	0.44
222	ACE_INHIBITOR_PATHWAY_ PHARMGKB		8	NOS3(1), REN(1)	24480	2	2	2	1	1	0	0	1	0	0.16	0.44
223	HSA00670_ONE_CARBON_ POOL_BY_FOLATE	Genes involved in one carbon pool by folate	16	ALDH1L1(2), MTHFD1L(1)	25509	3	3	3	4	1	1	0	0	1	0.16	0.44
224	ONE_CARBON_POOL_ BY_FOLATE		15	ALDH1L1(2), MTHFD1L(1)	25509	3	3	3	4	1	1	0	0	1	0.16	0.44
225	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	14	WASL(2)	32512	2	2	2	0	0	0	0	1	1	0.16	0.44
226	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	22	CHUK(2), CREBBP(2), MAP2K6(1)	102272	5	5	5	1	0	2	0	0	3	0.17	0.47
227	HSA00640_PROPANOATE_ METABOLISM	Genes involved in propanoate metabolism	33	ACACA(2), ACACB(4), ACSS1(1), ALDH3A1(1), EHHADH(1), LDHC(1)	148171	10	10	10	6	2	2	4	2	0	0.17	0.47
228	HSA00760_NICOTINATE_ AND_NICOTINAMIDE_ METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	22	ENPP3(2), NNMT(1), NNT(1), NT5E(1)	63101	5	5	5	2	2	0	2	1	0	0.18	0.48
229	FRUCTOSE_AND_MANNOSE_ METABOLISM		25	GCK(2), GMPPA(4), HK1(1), PFKP(1)	154858	8	7	8	3	0	3	2	3	0	0.18	0.49
230	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	25	EIF2B4(2), FLT4(5), NOS3(1), PRKCA(2), PTK2(2)	155090	12	11	12	1	4	3	3	2	0	0.18	0.49
231	ST_ERK1_ERK2_MAPK_ PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	29	BRAF(4), CREB1(1), RPS6KA2(1), SOS1(3)	111058	9	9	9	2	2	3	2	2	0	0.19	0.50
232	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	17	CREB1(1), NTRK1(4)	82432	5	5	4	2	0	2	0	1	2	0.19	0.50
233	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	15	EGFR(7), POLR2A(1), PRKCA(2), TERT(1)	135904	11	9	9	3	2	4	3	2	0	0.19	0.50
234	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	13	IL10RA(1), JAK1(1), JAK2(1), STAT1(2), STAT5B(1)	68698	6	6	6	1	2	2	0	1	1	0.19	0.50
235	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	12	SKP2(2)	23400	2	2	2	0	0	1	0	1	0	0.19	0.50
236	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	9	SKP2(2)	23400	2	2	2	0	0	1	0	1	0	0.19	0.50
237	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	6	ADAM17(2), PRKCA(2)	34535	4	4	4	3	2	1	1	0	0	0.19	0.51
238	ST_B_CELL_ANTIGEN_ RECEPTOR	B cell receptors bind antigens and promote B cell activation.	39	BCR(1), BLNK(1), BTK(4), EPHB2(1), LYN(1), NFAT5(2), SOS1(3)	209546	13	13	13	2	1	4	6	0	2	0.20	0.51
239	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	18	CHUK(2)	50546	2	2	2	0	0	0	0	0	2	0.20	0.51
240	HSA00534_HEPARAN_ SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	19	EXT2(1), EXTL1(1), NDST2(2)	36619	4	4	4	1	2	2	0	0	0	0.20	0.51
241	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	22	BTK(4), EPHB2(1), F2RL2(3), PTK2(2)	119864	10	10	10	2	1	4	3	0	2	0.20	0.52
242	HSA04630_JAK_STAT_ SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	152	CREBBP(2), IFNA16(2), IL10RA(1), IL12RB2(2), IL19(1), IL21R(2), IL28B(1), IL5RA(1), JAK1(1), JAK2(1), LEPR(1), PIAS1(1), PIK3R5(2), SOS1(3), STAT1(2), STAT2(2), STAT5B(1), TPO(6), TSLP(1)	467142	33	25	33	11	8	12	4	4	5	0.20	0.52
243	HSA00030_PENTOSE_ PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	26	GPI(2), PFKP(1), PGD(1), TKTL1(3)	113030	7	7	7	4	0	2	2	2	1	0.21	0.53
244	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	21	CHUK(2)	49152	2	2	2	1	0	0	0	0	2	0.21	0.54
245	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	7	JAK1(1), JAK2(1)	26458	2	2	2	0	0	1	0	1	0	0.21	0.54
246	ST_INTERLEUKIN_13_ PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	7	JAK1(1), JAK2(1)	26458	2	2	2	0	0	1	0	1	0	0.21	0.54
247	SIG_IL4RECEPTOR_ IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	27	JAK1(1), SOS1(3)	58006	4	4	4	2	1	0	2	1	0	0.22	0.55
248	APOPTOSIS_KEGG		48	CASP10(2), NTRK1(4), PTPN13(3), SFRS2IP(1), TNFRSF1B(1)	128774	11	9	10	3	3	4	1	1	2	0.23	0.58
249	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	42	LAT(1), MAP2K4(1), NFATC3(2), PPP3CC(1), PRKCA(2), RASA1(1), SOS1(3)	162663	11	10	11	5	5	0	4	1	1	0.24	0.58
250	HSA00220_UREA_CYCLE_ AND_METABOLISM_OF_ AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	30	ADC(1), ALDH3A1(1), AOC2(1), CPS1(8)	141540	11	11	11	5	3	2	3	1	2	0.24	0.58
251	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	13	CREBBP(2), PML(1), SP100(2), TNFRSF1B(1)	75015	6	6	6	1	1	1	3	0	1	0.24	0.58
252	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	11	JAK1(1)	19805	1	1	1	0	0	0	0	1	0	0.25	0.61
253	HSA04340_HEDGEHOG_ SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	56	CSNK1G1(1), GLI1(5), LRP2(3), STK36(2), WNT7A(3)	168967	14	13	14	2	3	7	3	1	0	0.26	0.63
254	HSA04210_APOPTOSIS	Genes involved in apoptosis	82	ATM(5), CASP10(2), CHUK(2), IRAK2(2), IRAK3(2), NTRK1(4), PIK3R5(2), PPP3CC(1)	344316	20	18	19	3	3	8	2	2	5	0.26	0.63
255	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_ DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	23	ACP5(2), ACP6(1), ACPP(1), ALPP(1), CYP3A7(3)	98456	8	7	8	1	2	5	0	0	1	0.26	0.63
256	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	22	JAK1(1), SOS1(3), STAT5B(1)	73125	5	5	5	2	2	0	2	1	0	0.26	0.64
257	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	9	PRKCA(2)	25946	2	2	2	1	2	0	0	0	0	0.27	0.64
258	SIG_PIP3_SIGNALING_ IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	63	CREB1(1), F2RL2(3), IFI27(1), IRS4(7), MET(2), NOLC1(1), PARD3(1), PTK2(2), RPS6KA2(1), SOS1(3)	342970	22	19	22	5	5	6	8	2	1	0.27	0.64
259	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	7	CD36(1)	5236	1	1	1	0	0	1	0	0	0	0.27	0.64
260	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	13	F5(4)	36941	4	4	4	4	1	2	1	0	0	0.27	0.64
261	PURINE_METABOLISM		110	ADA(1), ADCY2(4), ADCY3(1), ADCY4(1), ADCY5(4), ADCY8(7), ENPP3(2), GUCY2C(3), IMPDH2(1), NT5E(1), PAPSS2(1), PDE1A(1), PDE4C(2), PDE6C(2), PDE7B(1), PDE8A(1), PFAS(1), POLD1(2), POLQ(3), POLR2A(1), POLR2G(1), RRM1(1)	784889	42	29	42	18	6	15	8	4	9	0.27	0.64
262	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	15	CHUK(2)	65865	2	2	2	0	0	0	0	0	2	0.27	0.65
263	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	27	CHUK(2), PPP3CC(1)	67918	3	3	3	0	1	0	0	0	2	0.28	0.65
264	PENTOSE_PHOSPHATE_ PATHWAY		23	GPI(2), PFKP(1), PGD(1)	97350	4	4	4	4	0	2	0	2	0	0.28	0.65
265	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	7	LDLR(2)	16638	2	2	2	1	0	2	0	0	0	0.28	0.66
266	HSA00565_ETHER_LIPID_ METABOLISM	Genes involved in ether lipid metabolism	30	AGPS(1), ENPP2(2), PLA2G4A(3)	61762	6	5	6	3	1	3	2	0	0	0.29	0.67
267	GLYCINE_SERINE_AND_ THREONINE_METABOLISM		37	AOC2(1), DLD(2), GARS(1), GCAT(2), GLDC(4), PSPH(1), SARDH(1)	155833	12	10	12	2	4	4	1	1	2	0.29	0.68
268	HSA00500_STARCH_ AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	83	AGL(3), DDX4(1), DDX54(1), ENPP3(2), GCK(2), GPI(2), GYS2(2), HK1(1), MGAM(6), RUVBL2(1), SETX(1), SKIV2L2(2), SMARCA2(3), TREH(1), UGT2B15(1)	526007	29	24	28	9	9	12	1	5	2	0.30	0.68
269	HSA00401_NOVOBIOCIN_ BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	3	TAT(1)	9428	1	1	1	1	1	0	0	0	0	0.30	0.68
270	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	22	MYLK(4), PPP1R12B(2), TRIO(2), WASF1(2)	164348	10	8	10	4	1	4	1	2	2	0.30	0.68
271	FATTY_ACID_BIOSYNTHESIS_ PATH_2		9	EHHADH(1), HADHB(3)	40057	4	4	4	0	2	1	1	0	0	0.30	0.68
272	HSA04620_TOLL_LIKE_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in Toll-like receptor signaling pathway	100	CHUK(2), IFNA16(2), MAP2K4(1), MAP2K6(1), PIK3R5(2), STAT1(2), TLR9(3), TOLLIP(1)	254763	14	12	14	4	4	4	1	1	4	0.30	0.69
273	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	15	MAPKAPK2(1)	9810	1	1	1	0	1	0	0	0	0	0.31	0.69
274	HSA00650_BUTANOATE_ METABOLISM	Genes involved in butanoate metabolism	45	AACS(1), ACSM1(1), ALDH3A1(1), EHHADH(1), HSD17B4(2)	82789	6	6	6	3	2	1	2	1	0	0.31	0.69
275	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	8	ACLY(2), PC(1)	75347	3	3	2	1	0	0	3	0	0	0.31	0.69
276	SIG_INSULIN_RECEPTOR_ PATHWAY_IN_CARDIAC_ MYOCYTES	Genes related to the insulin receptor pathway	49	BRD4(3), F2RL2(3), IRS4(7), PARD3(1), RPS6KA2(1), SORBS1(3), SOS1(3)	316834	21	18	21	5	5	5	7	2	2	0.31	0.69
277	BIOGENIC_AMINE_SYNTHESIS		15	DDC(2)	27228	2	2	2	0	0	1	0	0	1	0.31	0.69
278	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	52	CHUK(2), LMNB1(1), PRKDC(5), PTK2(2), RASA1(1), SPTAN1(3), TNFRSF1B(1)	291654	15	14	15	4	4	1	5	1	4	0.32	0.71
279	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	10	ACACA(2), LEPR(1), PRKAG2(1)	51357	4	4	4	2	1	1	1	1	0	0.32	0.71
280	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	8	ATM(5)	70044	5	5	5	0	1	1	1	1	1	0.33	0.72
281	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	13	CHUK(2)	79300	2	2	2	0	0	0	0	0	2	0.33	0.73
282	BUTANOATE_METABOLISM		27	AACS(1), ALDH3A1(1), EHHADH(1)	39933	3	3	3	2	0	1	2	0	0	0.33	0.73
283	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	18	CABIN1(2), HDAC2(1), PPP3CC(1), PRKCA(2)	108045	6	5	6	1	4	0	1	0	1	0.34	0.73
284	HSA04115_P53_SIGNALING_ PATHWAY	Genes involved in p53 signaling pathway	65	ATM(5), BAI1(1), CDK4(1), CDK6(1), LRDD(1)	136369	9	9	9	1	2	3	1	2	1	0.34	0.75
285	HSA04740_OLFACTORY_ TRANSDUCTION	Genes involved in olfactory transduction	30	ADCY3(1), ADRBK2(1), CAMK2A(1), CAMK2B(3), CAMK2D(1), CLCA4(3), CNGB1(1)	128815	11	9	11	2	4	4	2	0	1	0.35	0.76
286	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	15	CASP10(2)	47342	2	2	2	0	0	0	1	1	0	0.35	0.76
287	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	43	DLAT(1), DLD(2), GCK(2), GPI(2), HK1(1), LDHC(1), PC(1), PFKP(1), PGK1(2)	223903	13	13	13	6	2	5	2	3	1	0.36	0.77
288	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	21	ATM(5), FANCG(2), RAD51(1)	145072	8	8	8	1	1	1	3	1	2	0.36	0.77
289	HSA00051_FRUCTOSE_ AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	40	GMPPA(4), HK1(1), PFKP(1)	132821	6	6	6	2	0	2	2	2	0	0.36	0.77
290	HSA00130_UBIQUINONE_ BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	8	COQ3(1)	18598	1	1	1	0	0	0	0	0	1	0.36	0.77
291	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	16	PTK2(2), SOS1(3)	69411	5	5	5	2	1	1	3	0	0	0.36	0.77
292	HSA05130_PATHOGENIC_ ESCHERICHIA_COLI_ INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	51	CDH1(1), PRKCA(2), TUBA4A(1), TUBB4(1), WASL(2)	161468	7	7	7	3	5	0	0	1	1	0.37	0.77
293	HSA05131_PATHOGENIC_ ESCHERICHIA_COLI_ INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	51	CDH1(1), PRKCA(2), TUBA4A(1), TUBB4(1), WASL(2)	161468	7	7	7	3	5	0	0	1	1	0.37	0.77
294	APOPTOSIS		68	BIRC5(1), CASP10(2), CHUK(2), MAP2K4(1), TNFRSF1B(1)	184614	7	6	7	0	1	0	2	1	3	0.37	0.77
295	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	25	CHUK(2), MAP2K4(1), MAP2K6(1)	163853	4	4	4	0	0	1	0	0	3	0.37	0.78
296	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	6	PER1(1)	16534	1	1	1	0	0	0	1	0	0	0.38	0.79
297	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	22	BCR(1), JAK2(1), MAP2K4(1), SOS1(3), STAT1(2), STAT5B(1)	103087	9	8	9	3	3	3	2	0	1	0.38	0.79
298	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	18	CSF1R(2), DDX20(1), HDAC2(1), HDAC5(1), NCOR2(3), RBL1(1)	137254	9	9	9	5	4	1	2	1	1	0.38	0.79
299	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	18	CHUK(2), TNFRSF1B(1)	89140	3	3	3	0	1	0	0	0	2	0.39	0.79
300	GLUCONEOGENESIS		53	ADH1B(4), ADH6(2), ALDH3A1(1), DLAT(1), DLD(2), GCK(2), GPI(2), HK1(1), LDHC(1), PFKP(1), PGK1(2)	303551	19	18	19	8	4	8	2	3	2	0.39	0.79
301	GLYCOLYSIS		53	ADH1B(4), ADH6(2), ALDH3A1(1), DLAT(1), DLD(2), GCK(2), GPI(2), HK1(1), LDHC(1), PFKP(1), PGK1(2)	303551	19	18	19	8	4	8	2	3	2	0.39	0.79
302	HSA04110_CELL_CYCLE	Genes involved in cell cycle	110	ATM(5), CDK4(1), CDK6(1), CREBBP(2), HDAC2(1), MCM2(1), ORC2L(1), ORC3L(2), PLK1(1), PRKDC(5), RBL1(1), SKP2(2), SMC1A(1)	365381	24	22	24	3	7	6	5	3	3	0.39	0.79
303	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	37	MAP2K6(1), NFATC3(2), PLCB1(5), PPP3CC(1)	197824	9	8	9	2	3	1	1	1	3	0.39	0.79
304	HSA00770_PANTOTHENATE_ AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	16	BCAT2(2), DPYS(3), ENPP3(2), PANK3(1), PANK4(1)	117442	9	9	9	2	3	4	1	1	0	0.39	0.79
305	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	5	CYP2E1(1)	8398	1	1	1	1	0	1	0	0	0	0.39	0.79
306	ST_T_CELL_SIGNAL_ TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	44	EPHB2(1), GRAP2(1), LAT(1), NFAT5(2), PTPRC(6), RASGRP3(1), SOS1(3)	204913	15	14	15	4	5	5	4	0	1	0.39	0.79
307	CHOLESTEROL_BIOSYNTHESIS		15	HMGCR(1)	16516	1	1	1	0	0	0	1	0	0	0.40	0.80
308	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	12	GNAS(3), PLCE1(2)	74819	5	5	5	3	2	0	2	0	1	0.40	0.81
309	HSA05120_EPITHELIAL_ CELL_SIGNALING_IN_ HELICOBACTER_PYLORI_ INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	66	ADAM17(2), ATP6V1B1(1), ATP6V1H(1), CHUK(2), EGFR(7), LYN(1), MAP2K4(1), MET(2)	315831	17	14	15	3	2	4	6	2	3	0.41	0.81
310	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	5	ADAM17(2), NOTCH1(2)	59457	4	4	4	2	1	1	2	0	0	0.41	0.81
311	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	7	CREBBP(2)	33527	2	2	2	1	0	1	0	0	1	0.41	0.81
312	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	12	ATM(5), CDK4(1)	83335	6	6	6	0	1	2	1	1	1	0.41	0.82
313	VALINE_LEUCINE_AND_ ISOLEUCINE_DEGRADATION		36	ALDH3A1(1), EHHADH(1), HADHB(3), MCCC2(2)	81030	7	7	7	2	2	3	2	0	0	0.42	0.82
314	BIOSYNTHESIS_OF_ STEROIDS		14	HMGCR(1)	17596	1	1	1	0	0	0	1	0	0	0.42	0.82
315	CARBON_FIXATION		21	PGK1(2)	40574	2	2	2	0	1	0	0	0	1	0.42	0.83
316	PROPANOATE_METABOLISM		31	ACACA(2), ALDH3A1(1), EHHADH(1), LDHC(1)	114091	5	5	5	5	0	1	3	1	0	0.43	0.84
317	HSA05110_CHOLERA_ INFECTION	Genes involved in cholera - infection	41	ACTG2(2), ADCY3(1), ARF5(1), ATP6V1H(1), GNAS(3), PRKCA(2), SEC61A1(1)	159080	11	11	11	3	4	2	3	0	2	0.43	0.84
318	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	21	CASP10(2), LMNB1(1)	84049	3	2	3	0	0	0	1	1	1	0.44	0.85
319	HSA00902_MONOTERPENOID_ BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	2	CYP2C19(1)	9840	1	1	1	0	0	1	0	0	0	0.44	0.85
320	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	14	APC(4), AXIN1(1), CREBBP(2), DVL1(1)	116122	8	8	8	2	1	4	1	1	1	0.44	0.85
321	DNA_REPLICATION_ REACTOME		42	MCM2(1), ORC2L(1), ORC3L(2), POLA2(1), POLD1(2)	109017	7	6	7	0	1	2	3	0	1	0.45	0.86
322	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	18	SOS1(3)	49000	3	3	3	2	1	0	2	0	0	0.46	0.89
323	SA_B_CELL_RECEPTOR_ COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	24	BCR(1), BLNK(1), LYN(1), SOS1(3)	130011	6	6	6	4	1	1	4	0	0	0.47	0.89
324	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	14	CAMK2A(1), CAMK2B(3), CAMK2D(1), CAMK4(3), CAMKK1(1), CREB1(1)	134245	10	9	10	1	3	4	1	1	1	0.47	0.89
325	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	12	ADAM17(2), APC(4), AXIN1(1), DVL1(1), NOTCH1(2)	142052	10	9	10	3	2	4	3	1	0	0.47	0.90
326	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	15	SOS1(3)	51872	3	3	3	2	1	0	2	0	0	0.48	0.90
327	WNT_SIGNALING	Wnt signaling genes	59	APC(4), AXIN1(1), DVL1(1), DVL3(3), FZD2(1), LDLR(2), PPP2R5C(1), PRKCA(2), PRKCE(1), WNT7A(3)	253100	19	16	19	3	4	9	3	1	2	0.48	0.91
328	MITOCHONDRIAL_FATTY_ ACID_BETAOXIDATION		15	ACSL3(1), EHHADH(1)	38659	2	2	2	0	0	1	0	0	1	0.49	0.91
329	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	14	DYRK1A(1)	32448	1	1	1	0	0	0	0	0	1	0.49	0.91
330	HSA00020_CITRATE_ CYCLE	Genes involved in citrate cycle (TCA cycle)	27	ACLY(2), DLD(2), IDH3B(1), OGDH(1), PC(1)	174183	7	7	6	1	1	1	4	1	0	0.49	0.91
331	FOSBPATHWAY	FOSB gene expression and drug abuse	5	FOSB(1)	23067	1	1	1	0	1	0	0	0	0	0.49	0.91
332	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	39	CREB1(1), DDIT3(1), MAP2K4(1), MAP2K6(1), MAPKAPK2(1), PLA2G4A(3), STAT1(2)	149462	10	9	10	2	4	3	1	1	1	0.50	0.93
333	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	32	CASP10(2), CHUK(2), SPTAN1(3)	176260	7	6	7	1	1	0	3	1	2	0.50	0.93
334	HSA00624_1_AND_2_ METHYLNAPHTHALENE_ DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	22	ADH1B(4), ADH6(2)	90096	6	6	6	2	2	3	0	0	1	0.51	0.93
335	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	13	APC(4), CDH1(1), CREBBP(2)	111881	7	7	7	2	1	3	1	1	1	0.51	0.94
336	GPCRDB_OTHER		53	CELSR1(2), CELSR3(6), CXCR3(1), EMR2(1), EMR3(2), GPR116(1), GPR61(1), GRM1(8), LGR6(2), OR8G2(2)	386244	26	22	26	6	8	9	5	2	2	0.51	0.94
337	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	38	DLD(2), GCK(2), MAP2K4(1), MAP3K12(1), NFATC3(2), ZAK(2)	276848	10	8	10	4	1	3	2	3	1	0.51	0.94
338	GLUCOCORTICOID_MINERALOCORTICOID_ METABOLISM		8	CYP11B2(2)	23466	2	2	2	4	0	2	0	0	0	0.51	0.94
339	TRYPTOPHAN_METABOLISM		54	ALDH3A1(1), AOC2(1), CYP2A13(2), CYP2C19(1), CYP2E1(1), CYP3A7(3), CYP4F8(2), DDC(2), EHHADH(1), GCDH(1), WARS(1)	240555	16	15	16	5	4	8	2	0	2	0.52	0.94
340	NUCLEAR_RECEPTORS		40	ALK(7), NR0B1(2), NR1H3(2), RORC(1), THRB(1)	190622	13	12	13	4	3	5	2	2	1	0.53	0.95
341	HSA00232_CAFFEINE_ METABOLISM	Genes involved in caffeine metabolism	7	CYP2A13(2)	26951	2	2	2	0	0	2	0	0	0	0.53	0.95
342	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	32	APC(4), AXIN1(1), DVL1(1)	89675	6	6	6	1	1	3	1	1	0	0.53	0.96
343	FOLATE_BIOSYNTHESIS		9	ALPP(1), GGH(2)	35160	3	2	3	1	1	1	1	0	0	0.53	0.96
344	NUCLEOTIDE_METABOLISM		14	POLD1(2), RRM1(1)	84238	3	3	3	0	0	0	2	0	1	0.54	0.97
345	CIRCADIAN_EXERCISE		40	PER1(1), ZFR(2)	72558	3	3	3	1	0	1	1	1	0	0.54	0.97
346	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	7	JAK1(1), JAK2(1)	52059	2	2	2	1	0	1	0	1	0	0.54	0.97
347	SA_REG_CASCADE_OF_ CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	13	CDK4(1)	13281	1	1	1	0	0	1	0	0	0	0.55	0.97
348	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	9	HK1(1), TREH(1)	51075	2	1	2	2	0	1	0	1	0	0.55	0.98
349	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	21	EIF4B(2), EIF4G3(4)	81509	6	5	6	0	2	2	2	0	0	0.55	0.98
350	O_GLYCAN_BIOSYNTHESIS		14	GALNT1(3), GALNT7(1), GALNT8(1)	106643	5	5	5	3	1	2	0	1	1	0.56	0.98
351	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	16	PTK2B(2), SOS1(3)	68931	5	5	5	2	1	2	2	0	0	0.56	0.98
352	SELENOAMINO_ACID_ METABOLISM		12	MARS(1), PAPSS2(1)	26075	2	2	2	1	0	2	0	0	0	0.56	0.98
353	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	20	RASA1(1), SOS1(3)	97829	4	4	4	3	1	0	3	0	0	0.57	0.99
354	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	57	ASH1L(3), DOT1L(1), MLL(2), MLL4(2), OGT(2), SETD1A(1), SETD2(4), WHSC1L1(4)	477256	19	17	19	7	5	4	3	4	3	0.57	0.99
355	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	20	ATM(5), PRKCA(2), PTK2(2), STAT1(2), TLN1(3)	225939	14	13	14	2	5	4	2	1	2	0.57	0.99
356	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	15	JAK2(1), SOS1(3), STAT5B(1)	89654	5	5	5	2	2	1	2	0	0	0.58	0.99
357	LIMONENE_AND_PINENE_ DEGRADATION		12	ALDH3A1(1), EHHADH(1)	33093	2	2	2	1	0	1	1	0	0	0.58	0.99
358	CYSTEINE_METABOLISM		8	LDHC(1)	25198	1	1	1	3	0	0	1	0	0	0.58	0.99
359	HSA00272_CYSTEINE_ METABOLISM	Genes involved in cysteine metabolism	17	LDHC(1)	25198	1	1	1	3	0	0	1	0	0	0.58	0.99
360	AMINOACYL_TRNA_BIOSYNTHESIS		21	GARS(1), HARS(1), LARS(4), LARS2(1), MARS(1), WARS(1)	154860	9	8	9	4	1	5	2	1	0	0.58	1.00
361	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	22	CHUK(2), TNFRSF1B(1)	132751	3	3	3	0	1	0	0	0	2	0.59	1.00
362	HSA00310_LYSINE_ DEGRADATION	Genes involved in lysine degradation	47	ALDH3A1(1), DOT1L(1), EHHADH(1), GCDH(1), HSD17B4(2), OGDH(1), SETD1A(1)	200587	8	8	8	2	3	2	1	2	0	0.59	1.00
363	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	28	MAP2K4(1), PRKCA(2), PTK2B(2), SOS1(3)	110232	8	8	8	3	3	2	2	0	1	0.59	1.00
364	HSA03060_PROTEIN_ EXPORT	Genes involved in protein export	8	OXA1L(1)	15240	1	1	1	0	0	1	0	0	0	0.59	1.00
365	HSA00100_BIOSYNTHESIS_ OF_STEROIDS	Genes involved in biosynthesis of steroids	24	HMGCR(1)	26836	1	1	1	0	0	0	1	0	0	0.59	1.00
366	HSA01031_GLYCAN_ STRUCTURES_BIOSYNTHESIS_ 2	Genes involved in glycan structures - biosynthesis 2	60	B4GALT3(1), PIGG(1), PIGO(2)	118150	4	4	4	0	0	1	3	0	0	0.59	1.00
367	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	21	JAK1(1), JAK2(1), SOS1(3)	107315	5	5	5	2	1	1	2	1	0	0.60	1.00
368	GLUTATHIONE_METABOLISM		31	PGD(1)	74845	1	1	1	1	0	0	0	1	0	0.60	1.00
369	GPCRDB_CLASS_A_RHODOPSIN_ LIKE		164	AVPR2(1), CXCR3(1), F2RL2(3), LTB4R(1), NPY1R(1), NTSR2(1), RGR(1), RHO(1)	310776	10	9	10	1	3	2	2	3	0	0.61	1.00
370	HSA04120_UBIQUITIN_ MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	39	SKP2(2), SMURF1(1), SMURF2(2)	100818	5	5	5	0	2	1	1	1	0	0.61	1.00
371	HSA04140_REGULATION_ OF_AUTOPHAGY	Genes involved in regulation of autophagy	29	IFNA16(2), ULK2(2)	68125	4	4	4	0	2	2	0	0	0	0.61	1.00
372	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	24	CXCR3(1), EGFR(7), ITGA1(1), MYLK(4), PTK2(2), TLN1(3)	287659	18	16	16	5	3	7	4	2	2	0.62	1.00
373	HSA04614_RENIN_ANGIOTENSIN_ SYSTEM	Genes involved in renin-angiotensin system	17	ACE2(1), CTSG(1), REN(1)	80795	3	3	3	1	1	0	1	1	0	0.62	1.00
374	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	22	EIF4G3(4), PRKCA(2)	95305	6	6	6	2	3	2	1	0	0	0.62	1.00
375	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	15	INSR(1), MAGI1(3)	100982	4	4	4	1	2	0	1	1	0	0.62	1.00
376	HSA00010_GLYCOLYSIS_ AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	64	ACSS1(1), ADH1B(4), ADH6(2), ALDH3A1(1), DLAT(1), DLD(2), GCK(2), GPI(2), HK1(1), LDHC(1), PFKP(1), PGK1(2)	362370	20	19	20	9	5	8	2	3	2	0.62	1.00
377	HSA00521_STREPTOMYCIN_ BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	10	GCK(2), HK1(1)	76138	3	3	3	3	0	2	0	1	0	0.62	1.00
378	STREPTOMYCIN_BIOSYNTHESIS		8	GCK(2), HK1(1)	76138	3	3	3	3	0	2	0	1	0	0.62	1.00
379	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	23	PRKCA(2), PTK2(2), PTK2B(2)	83230	6	6	6	2	2	3	1	0	0	0.63	1.00
380	CITRATE_CYCLE_TCA_ CYCLE		20	DLD(2), IDH3B(1), PC(1)	110103	4	4	4	0	1	0	2	1	0	0.63	1.00
381	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	35	ARHGEF11(2), LPA(8), MAP2K4(1), PTK2(2)	259577	13	9	13	1	2	5	5	0	1	0.63	1.00
382	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	15	CDK4(1)	17011	1	1	1	0	0	1	0	0	0	0.63	1.00
383	HSA00260_GLYCINE_ SERINE_AND_THREONINE_ METABOLISM	Genes involved in glycine, serine and threonine metabolism	45	AOC2(1), DLD(2), GARS(1), GCAT(2), GLDC(4), PSPH(1), SARDH(1)	213563	12	10	12	2	4	4	1	1	2	0.64	1.00
384	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	23	APC(4), AXIN1(1), CREBBP(2), DVL1(1)	141138	8	8	8	2	1	4	1	1	1	0.64	1.00
385	BENZOATE_DEGRADATION_ VIA_COA_LIGATION		10	EHHADH(1), GCDH(1)	33701	2	2	2	0	1	1	0	0	0	0.64	1.00
386	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	26	JAK1(1), MAP2K4(1), PRKCA(2), RASA1(1), SOS1(3), STAT1(2)	180665	10	9	10	5	4	1	3	1	1	0.64	1.00
387	NUCLEOTIDE_GPCRS		8	LTB4R(1)	57000	1	1	1	0	0	0	0	1	0	0.64	1.00
388	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	22	GNAS(3)	74967	3	3	3	3	1	0	2	0	0	0.65	1.00
389	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	16	CREB1(1), MAP2K6(1)	85335	2	2	2	1	0	1	0	1	0	0.65	1.00
390	HSA00290_VALINE_ LEUCINE_AND_ISOLEUCINE_ BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	12	BCAT2(2), LARS(4), LARS2(1), VARS(2)	234288	9	9	9	2	1	3	3	2	0	0.65	1.00
391	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	34	JAK1(1), SOS1(3), STAT5B(1)	124296	5	5	5	3	2	0	2	1	0	0.65	1.00
392	HSA00230_PURINE_ METABOLISM	Genes involved in purine metabolism	142	ADA(1), ADCY2(4), ADCY3(1), ADCY4(1), ADCY5(4), ADCY8(7), AK7(3), ENPP3(2), GUCY2C(3), IMPDH2(1), NT5E(1), PAPSS2(1), PDE10A(4), PDE1A(1), PDE4C(2), PDE7B(1), PDE8A(1), PFAS(1), POLA2(1), POLD1(2), POLR2A(1), POLR2G(1), RRM1(1)	829823	45	32	45	17	9	15	11	3	7	0.66	1.00
393	GLYOXYLATE_AND_DICARBOXYLATE_ METABOLISM		12	GRHPR(1), MTHFD1L(1)	53961	2	2	2	1	2	0	0	0	0	0.66	1.00
394	APOPTOSIS_GENMAPP		42	MAP2K4(1), PARP1(1), TNFRSF1B(1)	119297	3	3	3	0	1	0	0	1	1	0.66	1.00
395	HSA00252_ALANINE_ AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	33	AARS2(2), CAD(3), DLAT(1), DLD(2), NARS2(1), PC(1)	235144	10	9	10	2	2	3	3	2	0	0.67	1.00
396	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	7	CREBBP(2)	59128	2	2	2	2	0	1	0	0	1	0.67	1.00
397	HSA00860_PORPHYRIN_ AND_CHLOROPHYLL_ METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	41	BLVRB(1), CP(3), EARS2(2), UGT2B15(1)	156217	7	7	7	0	4	1	2	0	0	0.68	1.00
398	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	48	ADCY4(1), ADCY8(7), CACNA1A(1), GNAS(3), ITPR3(4), PDE1A(1)	297325	17	15	17	13	4	5	5	1	2	0.68	1.00
399	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	13	C1QA(1), C2(2), C3(2), C6(2), C7(3), C9(1)	223531	11	11	11	5	2	7	0	1	1	0.68	1.00
400	HSA00630_GLYOXYLATE_ AND_DICARBOXYLATE_ METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	13	GRHPR(1), MTHFD1L(1)	56347	2	2	2	1	2	0	0	0	0	0.68	1.00
401	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	5	CHRNA1(3)	113596	3	3	3	0	2	0	0	1	0	0.69	1.00
402	PORPHYRIN_AND_CHLOROPHYLL_ METABOLISM		26	BLVRB(1), CP(3), UGT2B15(1)	96686	5	5	5	0	3	1	1	0	0	0.70	1.00
403	METHIONINE_METABOLISM		12	DNMT1(1), MARS(1)	39083	2	2	2	1	0	2	0	0	0	0.70	1.00
404	KREBS_TCA_CYCLE		30	DLAT(1), DLD(2), IDH3B(1), OGDH(1), PC(1)	130023	6	6	6	0	1	2	2	1	0	0.70	1.00
405	HSA00790_FOLATE_ BIOSYNTHESIS	Genes involved in folate biosynthesis	41	ALPP(1), DDX4(1), DDX54(1), GGH(2), RUVBL2(1), SETX(1), SKIV2L2(2), SMARCA2(3)	300130	12	10	11	5	5	2	1	2	2	0.71	1.00
406	HSA00930_CAPROLACTAM_ DEGRADATION	Genes involved in caprolactam degradation	13	EHHADH(1), HSD17B4(2)	100640	3	3	3	0	1	1	0	1	0	0.71	1.00
407	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	16	C1QA(1), C2(2), C3(2), C6(2), C7(3), C9(1)	229837	11	11	11	5	2	7	0	1	1	0.71	1.00
408	HSA00970_AMINOACYL_ TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	38	AARS2(2), EARS2(2), GARS(1), HARS(1), LARS(4), LARS2(1), MARS(1), NARS2(1), VARS(2), WARS(1)	399079	16	14	16	5	3	6	4	3	0	0.72	1.00
409	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	31	CHUK(2), IRAK2(2), IRAK3(2), MAP2K6(1), TOLLIP(1)	198497	8	8	8	0	1	5	0	0	2	0.73	1.00
410	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	10	IL5RA(1)	21840	1	1	1	0	0	1	0	0	0	0.73	1.00
411	G1_TO_S_CELL_CYCLE_ REACTOME		65	ATM(5), CDK4(1), CREB3L3(1), MCM2(1), ORC2L(1), ORC3L(2), POLA2(1), RBL1(1), TNXB(5)	399910	18	15	18	3	4	6	3	3	2	0.73	1.00
412	HISTIDINE_METABOLISM		24	ALDH3A1(1), AOC2(1), DDC(2), HARS(1)	84983	5	5	5	2	1	2	1	0	1	0.74	1.00
413	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	11	CREBBP(2)	70644	2	2	2	1	0	1	0	0	1	0.74	1.00
414	OVARIAN_INFERTILITY_ GENES		25	ATM(5), CDK4(1), NCOR1(1), ZP2(1)	137236	8	7	8	3	2	3	1	1	1	0.74	1.00
415	CALCINEURIN_NF_AT_ SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	92	CABIN1(2), CAMK2B(3), CAMK4(3), CREBBP(2), GRLF1(3), KPNA5(1), NFAT5(2), NFATC3(2), PPP3CC(1), PTPRC(6)	438012	25	20	25	3	7	9	4	1	4	0.75	1.00
416	COMPLEMENT_ACTIVATION_ CLASSICAL		15	C1QA(1), C2(2), C3(2), C6(2), C7(3), C8B(2), C9(1)	232291	13	13	13	5	3	7	1	1	1	0.75	1.00
417	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	14	NCOR2(3), POLR2A(1)	110901	4	4	4	1	1	2	0	1	0	0.76	1.00
418	HSA00271_METHIONINE_ METABOLISM	Genes involved in methionine metabolism	17	DNMT1(1), MARS(1), TAT(1)	55951	3	3	3	2	1	2	0	0	0	0.76	1.00
419	HSA04710_CIRCADIAN_ RHYTHM	Genes involved in circadian rhythm	11	PER1(1)	51488	1	1	1	2	0	0	1	0	0	0.77	1.00
420	HSA00400_PHENYLALANINE_ TYROSINE_AND_TRYPTOPHAN_ BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	9	TAT(1)	34388	1	1	1	1	1	0	0	0	0	0.77	1.00
421	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	13	CREB1(1), CREM(1), POLR2A(1)	114928	3	3	3	1	0	2	0	1	0	0.78	1.00
422	PEPTIDE_GPCRS		66	ATP8A1(1), AVPR2(1), CXCR3(1), NPY1R(1), NTSR2(1)	109775	5	4	5	0	1	2	1	1	0	0.78	1.00
423	GLYCOSAMINOGLYCAN_ DEGRADATION		11	IDUA(1)	82992	1	1	1	0	0	0	0	0	1	0.78	1.00
424	HSA00980_METABOLISM_ OF_XENOBIOTICS_BY_ CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	70	ADH1B(4), ADH6(2), ALDH3A1(1), CYP2C19(1), CYP2E1(1), CYP3A7(3), DHDH(1), UGT2B15(1)	268479	14	12	14	2	5	6	1	0	2	0.79	1.00
425	UBIQUINONE_BIOSYNTHESIS		15	NDUFA8(1), NDUFV1(1)	55241	2	1	2	0	0	2	0	0	0	0.79	1.00
426	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	18	JAK2(1), TNFRSF1B(1)	42505	2	2	2	0	1	1	0	0	0	0.79	1.00
427	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	4	BMP1(1)	52902	1	1	1	0	0	0	1	0	0	0.79	1.00
428	ALANINE_AND_ASPARTATE_ METABOLISM		21	CAD(3), PC(1)	176795	4	4	4	1	0	1	3	0	0	0.80	1.00
429	C21_STEROID_HORMONE_ METABOLISM		11	CYP11B2(2)	41064	2	2	2	5	0	2	0	0	0	0.80	1.00
430	HSA00140_C21_STEROID_ HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	11	CYP11B2(2)	41064	2	2	2	5	0	2	0	0	0	0.80	1.00
431	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	21	MAP2K4(1)	88581	1	1	1	1	0	0	0	0	1	0.80	1.00
432	HSA00720_REDUCTIVE_ CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	11	ACLY(2), ACSS1(1)	102720	3	3	2	2	1	0	2	0	0	0.81	1.00
433	HSA03022_BASAL_TRANSCRIPTION_ FACTORS	Genes involved in basal transcription factors	33	GTF2H1(1), TAF1(3), TAF2(3), TAF7L(1)	231533	8	7	8	2	0	2	4	1	1	0.82	1.00
434	HSA01030_GLYCAN_ STRUCTURES_BIOSYNTHESIS_ 1	Genes involved in glycan structures - biosynthesis 1	109	B4GALT3(1), CHPF(1), EXT2(1), EXTL1(1), FUT8(2), GALNT1(3), GALNT7(1), GALNT8(1), GALNTL2(2), GANAB(1), MAN1B1(2), NDST2(2), OGT(2)	483197	20	17	20	7	4	8	3	3	2	0.83	1.00
435	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	35	ACTN3(2), BCR(1), ITGA1(1), PPP1R12B(2), PTK2(2), SOS1(3), TLN1(3)	364069	14	11	14	5	3	5	3	0	3	0.84	1.00
436	HSA00590_ARACHIDONIC_ ACID_METABOLISM	Genes involved in arachidonic acid metabolism	51	ALOX12B(1), CYP2C19(1), CYP2E1(1), PLA2G4A(3)	118988	6	5	6	2	1	4	1	0	0	0.84	1.00
437	HSA00920_SULFUR_ METABOLISM	Genes involved in sulfur metabolism	14	PAPSS2(1), SULT1A2(1)	44022	2	2	2	0	1	1	0	0	0	0.84	1.00
438	SULFUR_METABOLISM		9	PAPSS2(1), SULT1A2(1)	44022	2	2	2	0	1	1	0	0	0	0.84	1.00
439	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	26	APC(4), AXIN1(1), DVL1(1), TOLLIP(1)	147909	7	7	7	1	2	3	1	1	0	0.85	1.00
440	AMINOSUGARS_METABOLISM		15	GCK(2), HK1(1), RENBP(1)	147706	4	4	4	2	0	2	1	1	0	0.85	1.00
441	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	23	CAMK2A(1), CAMK2B(3), CAMK2D(1), CAMK4(3), HDAC5(1), PPP3CC(1)	274413	10	8	10	2	5	3	1	0	1	0.87	1.00
442	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	22	ITGA1(1), MYLK(4), PTK2(2), TLN1(3)	246912	10	10	10	4	2	5	1	0	2	0.87	1.00
443	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	85	BRAF(4), CHUK(2), CREB1(1), MAP2K4(1), MAP2K6(1), MAP3K12(1), MAP4K3(1), MAPKAPK2(1), RPS6KA2(1), RPS6KA4(1), STAT1(2)	498514	16	16	16	6	3	7	0	2	4	0.88	1.00
444	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	19	JAK2(1), SOS1(3), STAT5B(1)	124198	5	5	5	2	2	1	2	0	0	0.88	1.00
445	HSA04350_TGF_BETA_ SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	89	ACVR1C(1), ACVRL1(1), CREBBP(2), ID3(1), INHBC(1), NODAL(1), PPP2R2A(2), RBL1(1), SMURF1(1), SMURF2(2)	371983	13	13	13	6	4	3	3	2	1	0.88	1.00
446	UBIQUITIN_MEDIATED_ PROTEOLYSIS		23	NRF1(1), UBE2L6(1)	48382	2	2	2	0	1	1	0	0	0	0.88	1.00
447	PENTOSE_AND_GLUCURONATE_ INTERCONVERSIONS		18	UGT2B15(1)	47249	1	1	1	0	1	0	0	0	0	0.88	1.00
448	HSA00150_ANDROGEN_ AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	54	ARSD(2), CYP11B2(2), HSD17B12(1), UGT2B15(1)	172990	6	6	6	5	1	5	0	0	0	0.89	1.00
449	HSA00511_N_GLYCAN_ DEGRADATION	Genes involved in N-glycan degradation	15	MAN2B1(2)	160821	2	2	2	0	1	0	0	1	0	0.89	1.00
450	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	33	MAP2K4(1), MAPK8IP1(1)	111108	2	2	2	2	1	0	0	0	1	0.89	1.00
451	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	21	INSR(1), RASA1(1), SOS1(3)	267761	5	5	5	4	1	0	4	0	0	0.89	1.00
452	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	35	CREB1(1), MAP2K4(1), MAP2K6(1), MAPKAPK2(1)	175171	4	4	4	0	1	1	0	1	1	0.89	1.00
453	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	22	CDK4(1), CDK6(1), RBL1(1)	80783	3	3	3	0	2	1	0	0	0	0.90	1.00
454	HSA00410_BETA_ALANINE_ METABOLISM	Genes involved in beta-alanine metabolism	25	ALDH3A1(1), AOC2(1), DPYS(3), EHHADH(1)	113400	6	6	6	3	2	3	1	0	0	0.90	1.00
455	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	20	LAT(1), PTK2B(2)	82934	3	3	3	2	1	2	0	0	0	0.91	1.00
456	ALKALOID_BIOSYNTHESIS_ II		5	AOC2(1)	54507	1	1	1	1	1	0	0	0	0	0.91	1.00
457	ANDROGEN_AND_ESTROGEN_ METABOLISM		30	ARSD(2), CYP11B2(2), UGT2B15(1)	134103	5	5	5	5	1	4	0	0	0	0.91	1.00
458	N_GLYCAN_BIOSYNTHESIS		21	B4GALT3(1), FUT8(2), MAN1B1(2)	120489	5	5	5	0	1	2	1	0	1	0.91	1.00
459	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	10	TOP2A(1)	67930	1	1	1	0	0	0	1	0	0	0.91	1.00
460	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	16	ACTN3(2), ITGA1(1), PTK2(2), SPTAN1(3), TLN1(3)	276574	11	10	11	2	3	3	3	0	2	0.91	1.00
461	HSA00040_PENTOSE_ AND_GLUCURONATE_ INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	25	UGT2B15(1)	54209	1	1	1	0	1	0	0	0	0	0.92	1.00
462	HSA00532_CHONDROITIN_ SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	17	CHPF(1)	96790	1	1	1	0	0	0	1	0	0	0.92	1.00
463	IRINOTECAN_PATHWAY_ PHARMGKB		17	ABCC1(1), ABCC2(1)	91068	2	2	2	4	0	2	0	0	0	0.93	1.00
464	LYSINE_DEGRADATION		31	ALDH3A1(1), DOT1L(1), EHHADH(1), GCDH(1)	119345	4	4	4	1	2	1	1	0	0	0.94	1.00
465	PHOSPHATIDYLINOSITOL_ SIGNALING_SYSTEM		82	ACVRL1(1), AURKB(1), PIK3C2A(1), PIK3C2B(2), PLCB1(5), PLCB4(3), PLCD1(1), PRKCA(2), PRKCE(1), RPS6KA2(1), RPS6KA4(1)	530014	19	17	19	4	8	4	3	1	3	0.94	1.00
466	HSA00380_TRYPTOPHAN_ METABOLISM	Genes involved in tryptophan metabolism	58	ALDH3A1(1), AOC2(1), DDC(2), EHHADH(1), GCDH(1), HSD17B4(2), OGDH(1), WARS(1)	212346	10	10	10	3	3	3	2	1	1	0.94	1.00
467	HSA00340_HISTIDINE_ METABOLISM	Genes involved in histidine metabolism	41	ALDH3A1(1), AOC2(1), DDC(2), HARS(1)	137011	5	5	5	2	1	2	1	0	1	0.94	1.00
468	HSA00533_KERATAN_ SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	16	B4GALT3(1), FUT8(2)	80233	3	3	3	0	1	1	1	0	0	0.95	1.00
469	HSA00564_GLYCEROPHOSPHOLIPID_ METABOLISM	Genes involved in glycerophospholipid metabolism	64	GPAM(1), PLA2G4A(3)	143737	4	3	4	2	1	1	2	0	0	0.96	1.00
470	PYRIMIDINE_METABOLISM		55	CAD(3), DPYS(3), NT5E(1), POLD1(2), POLQ(3), POLR2A(1), POLR2G(1), RRM1(1)	384066	15	13	15	3	1	6	5	1	2	0.96	1.00
471	ACETYLCHOLINE_SYNTHESIS		8		0	0	0	0	0	0	0	0	0	0	1.00	1.00
472	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
473	BLOOD_GROUP_GLYCOLIPID_ BIOSYNTHESIS_NEOLACTOSERIES		7		0	0	0	0	0	0	0	0	0	0	1.00	1.00
474	CYANOAMINO_ACID_ METABOLISM		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
475	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	8		0	0	0	0	0	0	0	0	0	0	1.00	1.00
476	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	15		0	0	0	0	0	0	0	0	0	0	1.00	1.00
477	HSA00031_INOSITOL_ METABOLISM	Genes involved in inositol metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
478	HSA00072_SYNTHESIS_ AND_DEGRADATION_ OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	9		0	0	0	0	0	0	0	0	0	0	1.00	1.00
479	HSA00300_LYSINE_ BIOSYNTHESIS	Genes involved in lysine biosynthesis	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
480	HSA00471_D_GLUTAMINE_ AND_D_GLUTAMATE_ METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
481	HSA00472_D_ARGININE_ AND_D_ORNITHINE_ METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	1		0	0	0	0	0	0	0	0	0	0	1.00	1.00
482	HSA00550_PEPTIDOGLYCAN_ BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
483	HSA00627_1,4_DICHLOROBENZENE_ DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	1		0	0	0	0	0	0	0	0	0	0	1.00	1.00
484	HSA00643_STYRENE_ DEGRADATION	Genes involved in styrene degradation	3		0	0	0	0	0	0	0	0	0	0	1.00	1.00
485	HSA00660_C5_BRANCHED_ DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
486	HSA00780_BIOTIN_ METABOLISM	Genes involved in biotin metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
487	HSA00785_LIPOIC_ ACID_METABOLISM	Genes involved in lipoic acid metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
488	HSA00830_RETINOL_ METABOLISM	Genes involved in retinol metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
489	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
490	INOSITOL_METABOLISM		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
491	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	13		0	0	0	0	0	0	0	0	0	0	1.00	1.00
492	LYSINE_BIOSYNTHESIS		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
493	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
494	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	10		0	0	0	0	0	0	0	0	0	0	1.00	1.00
495	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
496	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	3		0	0	0	0	0	0	0	0	0	0	1.00	1.00
497	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
498	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
499	ST_PAC1_RECEPTOR_ PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
500	SYNTHESIS_AND_DEGRADATION_ OF_KETONE_BODIES		4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
501	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	7		0	0	0	0	0	0	0	0	0	0	1.00	1.00
502	HSA03320_PPAR_SIGNALING_ PATHWAY	Genes involved in PPAR signaling pathway	67	ACSL3(1), ACSL5(1), CD36(1), EHHADH(1), NR1H3(2), SLC27A1(1), SLC27A4(1), SORBS1(3)	228563	11	11	11	2	3	5	2	0	1	1.00	1.00
503	BETA_ALANINE_METABOLISM		27	ALDH3A1(1), AOC2(1), DPYS(3), EHHADH(1)	137520	6	6	6	4	2	3	1	0	0	1.00	1.00
504	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	13	ACTN3(2), PTK2(2)	94258	4	3	4	0	1	2	1	0	0	1.00	1.00
505	GLYCEROPHOSPHOLIPID_ METABOLISM		49	AGPS(1), PLA2G4A(3)	102461	4	3	4	1	1	2	1	0	0	1.00	1.00
506	PROSTAGLANDIN_SYNTHESIS_ REGULATION		29	PLA2G4A(3)	83884	3	2	3	0	1	1	1	0	0	1.00	1.00
507	KERATAN_SULFATE_ BIOSYNTHESIS		10	B4GALT3(1), FUT8(2)	91211	3	3	3	0	1	1	1	0	0	1.00	1.00
508	HSA00903_LIMONENE_ AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	26	ALDH3A1(1), CYP2C19(1), EHHADH(1)	92466	3	3	3	3	0	2	1	0	0	1.00	1.00
509	MRNA_PROCESSING_ REACTOME		92	DDIT3(1), DDX20(1), DHX8(2), POLR2A(1), PPM1G(1), PRPF3(1), RBM5(1), SF3B1(2), SFRS14(1), SRRM1(2), SUPT5H(2)	465108	15	12	15	4	7	3	3	2	0	1.00	1.00
510	TRANSLATION_FACTORS		37	EIF2AK1(2), EIF2B4(2), EIF4G3(4)	251080	8	8	8	0	4	3	1	0	0	1.00	1.00
511	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	26	CREBBP(2), HDAC2(1), HDAC5(1), NCOR2(3), NR0B1(2), POLR2A(1)	317724	10	10	10	5	4	4	0	1	1	1.00	1.00
512	HSA00240_PYRIMIDINE_ METABOLISM	Genes involved in pyrimidine metabolism	86	CAD(3), DPYS(3), NT5E(1), POLA2(1), POLD1(2), POLR2A(1), POLR2G(1), RRM1(1)	431484	13	11	13	2	1	6	5	0	1	1.00	1.00
513	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	30	ARHGEF11(2), MYLK(4), PPP1R12B(2), TLN1(3)	371849	11	9	11	2	3	5	1	0	2	1.00	1.00
514	HSA00510_N_GLYCAN_ BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	41	B4GALT3(1), FUT8(2), GANAB(1), MAN1B1(2)	210505	6	5	6	2	1	3	1	0	1	1.00	1.00
515	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	22	CDK4(1), CDK6(1)	72902	2	2	2	1	1	1	0	0	0	1.00	1.00
516	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	25	INSR(1), JAK2(1), PRKCA(2), SOS1(3), STAT5B(1)	292491	8	8	8	4	4	1	3	0	0	1.00	1.00
517	HSA00450_SELENOAMINO_ ACID_METABOLISM	Genes involved in selenoamino acid metabolism	26	MARS(1), PAPSS2(1)	77082	2	2	2	1	0	2	0	0	0	1.00	1.00
518	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	30	CABIN1(2), HDAC5(1), INSR(1), MAP2K6(1), PPP3CC(1)	248450	6	5	6	2	2	1	2	0	1	1.00	1.00
519	HSA03050_PROTEASOME	Genes involved in proteasome	22	PSMB5(1), PSMB6(1), PSMD1(1)	125330	3	3	3	0	1	2	0	0	0	1.00	1.00
520	HSA00530_AMINOSUGARS_ METABOLISM	Genes involved in aminosugars metabolism	29	GFPT2(2), HK1(1), RENBP(1)	169013	4	4	4	2	1	2	1	0	0	1.00	1.00
521	OXIDATIVE_PHOSPHORYLATION		60	ATP6V1B1(1), ATP6V1H(1), ATP7A(2), NDUFA8(1), NDUFV1(1)	273078	6	5	6	0	2	4	0	0	0	1.00	1.00
522	SMALL_LIGAND_GPCRS		14	DNMT1(1)	47323	1	1	1	0	0	1	0	0	0	1.00	1.00
523	HSA00632_BENZOATE_ DEGRADATION_VIA_ COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	24	EHHADH(1), GCDH(1)	98471	2	2	2	2	1	1	0	0	0	1.00	1.00
524	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	8	OGDH(1)	51360	1	1	1	0	0	1	0	0	0	1.00	1.00
525	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	20	PSMB5(1), PSMB6(1)	102756	2	2	2	0	0	2	0	0	0	1.00	1.00
526	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	11	JAK2(1)	52166	1	1	1	0	0	1	0	0	0	1.00	1.00
527	HSA04612_ANTIGEN_ PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	73	CREB1(1), IFNA16(2), TAP2(1)	231900	4	4	4	1	1	2	0	1	0	1.00	1.00
528	HSA00531_GLYCOSAMINOGLYCAN_ DEGRADATION	Genes involved in glycosaminoglycan degradation	17	HGSNAT(3), IDUA(1)	232972	4	4	4	1	2	1	0	0	1	1.00	1.00
529	PROTEASOME		17	PSMB5(1), PSMB6(1)	117396	2	2	2	0	0	2	0	0	0	1.00	1.00
530	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	10	SNCAIP(1), UBE2L6(1)	120600	2	2	2	0	1	1	0	0	0	1.00	1.00
531	HSA01032_GLYCAN_ STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	29	HGSNAT(3), IDUA(1), MAN2B1(2)	372793	6	6	6	1	3	1	0	1	1	1.00	1.00
532	HSA00602_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_NEO_ LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	21	B4GALT3(1)	64325	1	1	1	0	0	1	0	0	0	1.00	1.00
533	SA_MMP_CYTOKINE_ CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	15	TNFRSF1B(1)	67679	1	1	1	2	1	0	0	0	0	1.00	1.00
534	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	10	TNFRSF1B(1)	71135	1	1	1	0	1	0	0	0	0	1.00	1.00
535	HSA00190_OXIDATIVE_ PHOSPHORYLATION	Genes involved in oxidative phosphorylation	113	ATP4A(1), ATP6V1B1(1), ATP6V1H(1), NDUFA8(1), NDUFV1(1)	357203	5	3	5	2	1	3	0	0	1	1.00	1.00
536	CAPROLACTAM_DEGRADATION		5	EHHADH(1)	72083	1	1	1	0	0	1	0	0	0	1.00	1.00
537	ATP_SYNTHESIS		21	ATP6V1B1(1), ATP6V1H(1)	147053	2	2	2	0	1	1	0	0	0	1.00	1.00
538	FLAGELLAR_ASSEMBLY		21	ATP6V1B1(1), ATP6V1H(1)	147053	2	2	2	0	1	1	0	0	0	1.00	1.00
539	PHOTOSYNTHESIS		22	ATP6V1B1(1), ATP6V1H(1)	147053	2	2	2	0	1	1	0	0	0	1.00	1.00
540	TYPE_III_SECRETION_ SYSTEM		21	ATP6V1B1(1), ATP6V1H(1)	147053	2	2	2	0	1	1	0	0	0	1.00	1.00
541	GLYCOSPHINGOLIPID_ METABOLISM		23	ARSD(2)	148004	2	2	2	0	0	2	0	0	0	1.00	1.00
542	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	10	LDHC(1)	75393	1	1	1	2	0	0	1	0	0	1.00	1.00
543	PHENYLALANINE_TYROSINE_ AND_TRYPTOPHAN_BIOSYNTHESIS		9	TAT(1)	76018	1	1	1	1	1	0	0	0	0	1.00	1.00
544	ST_TUMOR_NECROSIS_ FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	28	MAP2K4(1), TNFRSF1B(1)	158339	2	2	2	1	1	0	0	0	1	1.00	1.00
545	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	6	MST1(1), MST1R(1)	159790	2	2	2	3	1	1	0	0	0	1.00	1.00
546	HSA00960_ALKALOID_ BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	18	AOC2(1)	80434	1	1	1	3	1	0	0	0	0	1.00	1.00
547	HSA00600_SPHINGOLIPID_ METABOLISM	Genes involved in sphingolipid metabolism	36	ARSD(2)	161842	2	2	2	0	0	2	0	0	0	1.00	1.00
548	RNA_TRANSCRIPTION_ REACTOME		37	GTF2H1(1), POLR2A(1), POLR2G(1)	273641	3	3	3	0	0	2	1	0	0	1.00	1.00
549	RIBOSOMAL_PROTEINS		94	RPL3(1), RPS6KA2(1)	189599	2	2	2	1	0	2	0	0	0	1.00	1.00
550	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	23	POLR2A(1), POLR2G(1)	192815	2	2	2	0	0	2	0	0	0	1.00	1.00
551	RNA_POLYMERASE		14	POLR2A(1), POLR2G(1)	193044	2	2	2	0	0	2	0	0	0	1.00	1.00
552	HSA03010_RIBOSOME	Genes involved in ribosome	67	RPL3(1)	131642	1	1	1	1	0	1	0	0	0	1.00	1.00
553	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	12	ARFGAP3(1)	191821	1	1	1	0	0	1	0	0	0	1.00	1.00
554	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	12		50037	0	0	0	0	0	0	0	0	0	1.00	1.00
555	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	16		6997	0	0	0	0	0	0	0	0	0	1.00	1.00
556	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	6		38450	0	0	0	0	0	0	0	0	0	1.00	1.00
557	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	8		1440	0	0	0	0	0	0	0	0	0	1.00	1.00
558	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	22		31076	0	0	0	0	0	0	0	0	0	1.00	1.00
559	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	6		11560	0	0	0	0	0	0	0	0	0	1.00	1.00
560	BLOOD_GROUP_GLYCOLIPID_ BIOSYNTHESIS_LACTOSERIES		7		49565	0	0	0	0	0	0	0	0	0	1.00	1.00
561	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	12		29321	0	0	0	1	0	0	0	0	0	1.00	1.00
562	CHONDROITIN		8		9185	0	0	0	0	0	0	0	0	0	1.00	1.00
563	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	17		1712	0	0	0	0	0	0	0	0	0	1.00	1.00
564	EICOSANOID_SYNTHESIS		17		13640	0	0	0	1	0	0	0	0	0	1.00	1.00
565	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	9		33000	0	0	0	0	0	0	0	0	0	1.00	1.00
566	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	9		44184	0	0	0	0	0	0	0	0	0	1.00	1.00
567	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	8		5160	0	0	0	0	0	0	0	0	0	1.00	1.00
568	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	10		44201	0	0	0	0	0	0	0	0	0	1.00	1.00
569	GANGLIOSIDE_BIOSYNTHESIS		8		9314	0	0	0	0	0	0	0	0	0	1.00	1.00
570	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	16		1440	0	0	0	0	0	0	0	0	0	1.00	1.00
571	GLOBOSIDE_METABOLISM		13		30314	0	0	0	0	0	0	0	0	0	1.00	1.00
572	GPCRDB_CLASS_A_RHODOPSIN_ LIKE2		13		90997	0	0	0	1	0	0	0	0	0	1.00	1.00
573	HEME_BIOSYNTHESIS		9		41061	0	0	0	0	0	0	0	0	0	1.00	1.00
574	HEPARAN_SULFATE_ BIOSYNTHESIS		8		9185	0	0	0	0	0	0	0	0	0	1.00	1.00
575	HSA00363_BISPHENOL_ A_DEGRADATION	Genes involved in bisphenol A degradation	14		38208	0	0	0	0	0	0	0	0	0	1.00	1.00
576	HSA00430_TAURINE_ AND_HYPOTAURINE_ METABOLISM	Genes involved in taurine and hypotaurine metabolism	6		11880	0	0	0	0	0	0	0	0	0	1.00	1.00
577	HSA00440_AMINOPHOSPHONATE_ METABOLISM	Genes involved in aminophosphonate metabolism	16		27367	0	0	0	0	0	0	0	0	0	1.00	1.00
578	HSA00460_CYANOAMINO_ ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	6		11500	0	0	0	1	0	0	0	0	0	1.00	1.00
579	HSA00480_GLUTATHIONE_ METABOLISM	Genes involved in glutathione metabolism	37		99683	0	0	0	0	0	0	0	0	0	1.00	1.00
580	HSA00520_NUCLEOTIDE_ SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	6		2160	0	0	0	0	0	0	0	0	0	1.00	1.00
581	HSA00601_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	10		33194	0	0	0	0	0	0	0	0	0	1.00	1.00
582	HSA00603_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	14		21000	0	0	0	0	0	0	0	0	0	1.00	1.00
583	HSA00604_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	16		21000	0	0	0	0	0	0	0	0	0	1.00	1.00
584	HSA00625_TETRACHLOROETHENE_ DEGRADATION	Genes involved in tetrachloroethene degradation	7		19060	0	0	0	0	0	0	0	0	0	1.00	1.00
585	HSA00626_NAPHTHALENE_ AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	18		43988	0	0	0	0	0	0	0	0	0	1.00	1.00
586	HSA00642_ETHYLBENZENE_ DEGRADATION	Genes involved in ethylbenzene degradation	12		42068	0	0	0	2	0	0	0	0	0	1.00	1.00
587	HSA00730_THIAMINE_ METABOLISM	Genes involved in thiamine metabolism	8		10320	0	0	0	0	0	0	0	0	0	1.00	1.00
588	HSA00750_VITAMIN_ B6_METABOLISM	Genes involved in vitamin B6 metabolism	5		13800	0	0	0	0	0	0	0	0	0	1.00	1.00
589	HSA00791_ATRAZINE_ DEGRADATION	Genes involved in atrazine degradation	9		67584	0	0	0	1	0	0	0	0	0	1.00	1.00
590	HSA00900_TERPENOID_ BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	6		21960	0	0	0	0	0	0	0	0	0	1.00	1.00
591	HSA04130_SNARE_INTERACTIONS_ IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	35		51598	0	0	0	0	0	0	0	0	0	1.00	1.00
592	HYPERTROPHY_MODEL		17		11972	0	0	0	0	0	0	0	0	0	1.00	1.00
593	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	19		21856	0	0	0	0	0	0	0	0	0	1.00	1.00
594	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	13		1712	0	0	0	0	0	0	0	0	0	1.00	1.00
595	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	29		1440	0	0	0	0	0	0	0	0	0	1.00	1.00
596	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	19		34761	0	0	0	0	0	0	0	0	0	1.00	1.00
597	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	9		63951	0	0	0	0	0	0	0	0	0	1.00	1.00
598	MONOAMINE_GPCRS		32		105388	0	0	0	0	0	0	0	0	0	1.00	1.00
599	NUCLEOTIDE_SUGARS_ METABOLISM		5		2160	0	0	0	0	0	0	0	0	0	1.00	1.00
600	N_GLYCAN_DEGRADATION		13		117224	0	0	0	0	0	0	0	0	0	1.00	1.00
601	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	11		8879	0	0	0	0	0	0	0	0	0	1.00	1.00
602	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	9		34902	0	0	0	0	0	0	0	0	0	1.00	1.00
603	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	9		58234	0	0	0	0	0	0	0	0	0	1.00	1.00
604	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	12		47183	0	0	0	0	0	0	0	0	0	1.00	1.00
605	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	9		4362	0	0	0	0	0	0	0	0	0	1.00	1.00
606	REDUCTIVE_CARBOXYLATE_ CYCLE_CO2_FIXATION		9		30840	0	0	0	0	0	0	0	0	0	1.00	1.00
607	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	6		10320	0	0	0	1	0	0	0	0	0	1.00	1.00
608	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	7		20573	0	0	0	0	0	0	0	0	0	1.00	1.00
609	SA_PROGRAMMED_CELL_ DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	12		7401	0	0	0	0	0	0	0	0	0	1.00	1.00
610	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	15		1440	0	0	0	0	0	0	0	0	0	1.00	1.00
611	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	6		1712	0	0	0	0	0	0	0	0	0	1.00	1.00
612	TCRMOLECULE	T Cell Receptor and CD3 Complex	3		1712	0	0	0	0	0	0	0	0	0	1.00	1.00
613	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	6		27723	0	0	0	0	0	0	0	0	0	1.00	1.00
614	TERPENOID_BIOSYNTHESIS		4		12840	0	0	0	0	0	0	0	0	0	1.00	1.00
615	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	7		24730	0	0	0	0	0	0	0	0	0	1.00	1.00
616	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	16		3152	0	0	0	0	0	0	0	0	0	1.00	1.00

Notes: (Please see notes under significantly mutated gene table)