rank	geneset	description	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	p	q
1	GPCRDB_CLASS_B_SECRETIN_ LIKE		19	CALCR(2), CRHR1(3), CRHR2(1), EMR1(5), EMR2(3), GLP2R(2), GPR64(3)	63050	19	17	19	7	5	10	1	2	1	2.17e-06	0.0013
2	GPCRDB_CLASS_C_METABOTROPIC_ GLUTAMATE_PHEROMONE		12	CASR(5), GRM2(3)	19889	8	8	8	3	2	5	0	1	0	0.00037	0.11
3	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	22	APC(7), EPHB2(3), ITPR1(1), ITPR2(5), ITPR3(3), KCNJ9(3), MAPK1(1), RHO(1)	145209	24	22	24	3	5	11	2	2	4	0.00069	0.12
4	HSA04664_FC_EPSILON_ RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	72	BTK(2), IL4(1), INPP5D(4), LYN(1), MAP2K6(2), MAPK1(1), MAPK3(1), MS4A2(1), PIK3R5(4), PLA2G4A(4), PRKCA(3), PRKCE(2), RAF1(1), SOS1(3)	207363	30	25	30	7	6	17	0	3	4	0.00079	0.12
5	HSA00950_ALKALOID_ BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	5	DDC(3), TAT(3)	13232	6	6	6	1	2	4	0	0	0	0.0011	0.14
6	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	20	CD3E(1), CXCR3(1), IL12RB2(2), JAK2(3), MAP2K6(2)	40623	9	8	9	2	1	4	0	1	3	0.0015	0.15
7	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	12	NTRK1(5), PRKCA(3), SOS1(3)	61862	11	11	11	1	0	7	0	2	2	0.0020	0.18
8	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	9	GPI(3), HK1(3), PGK1(2)	37507	8	7	8	0	5	2	0	0	1	0.0023	0.18
9	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	22	JAK2(3), MAPK3(1), PRKCA(3), RAF1(1), RASA1(2), SOS1(3), STAT1(1), STAT5B(1)	108948	15	15	15	1	1	8	0	2	4	0.0030	0.21
10	ST_INTERLEUKIN_4_ PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	26	IL4(1), INPP5D(4), JAK2(3), SOS1(3)	56800	11	11	11	0	1	7	0	2	1	0.0042	0.25
11	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	15	CD3E(1), CXCR3(1), IL12RB2(2), JAK2(3)	29013	7	6	7	1	1	3	0	1	2	0.0044	0.25
12	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	18	BRCA1(5), RAD50(3), RAD51(1), RELA(2)	56240	11	9	11	2	1	7	0	1	2	0.0048	0.25
13	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	32	EGFR(2), EPHB2(3), ITPR1(1), ITPR2(5), ITPR3(3), KCNJ9(3), MAPK1(1), PLCB4(3), RAF1(1), SOS1(3)	171405	25	21	25	5	7	12	2	1	3	0.0055	0.26
14	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	22	PIGO(2), PIGQ(1)	11722	3	3	3	1	1	0	1	1	0	0.0063	0.28
15	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	6	ABCB1(9), ABCC1(4)	69312	13	12	13	2	4	8	0	1	0	0.0074	0.31
16	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	11	GNAS(2), PRKCA(3)	19909	5	5	5	2	0	3	0	1	1	0.010	0.39
17	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	20	F2RL3(1), ITGA1(1), MAPK1(1), MAPK3(1), PLA2G4A(4), PRKCA(3), PTK2(2), RAF1(1)	90512	14	12	14	4	4	6	0	2	2	0.011	0.40
18	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	5	PRKCA(3)	10200	3	3	3	0	0	1	0	1	1	0.012	0.42
19	ST_PHOSPHOINOSITIDE_ 3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	33	BTK(2), INPP5D(4), RPS6KA2(2), SOS1(3)	69184	11	11	11	0	1	7	0	2	1	0.013	0.44
20	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	35	DOCK1(3), ITGA1(1), MAPK1(1), MAPK3(1), MET(2), PAK1(1), PTK2(2), RAF1(1), RASA1(2), SOS1(3)	122965	17	14	17	4	3	8	2	1	3	0.017	0.47
21	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	18	ABCB1(9)	43020	9	8	9	2	2	6	0	1	0	0.017	0.47
22	C21_STEROID_HORMONE_ METABOLISM		11	CYP11B1(5), CYP11B2(3)	45443	8	8	8	1	2	4	0	2	0	0.018	0.47
23	HSA00140_C21_STEROID_ HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	11	CYP11B1(5), CYP11B2(3)	45443	8	8	8	1	2	4	0	2	0	0.018	0.47
24	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	12	CSF1R(2), EGFR(2), MET(2), PRKCA(3), SH3KBP1(2)	89437	11	9	11	1	1	5	1	3	1	0.019	0.48
25	HSA04640_HEMATOPOIETIC_ CELL_LINEAGE	Genes involved in hematopoietic cell lineage	85	CD19(1), CD1B(3), CD1E(3), CD22(4), CD36(1), CD3E(1), CD5(1), CR1(2), CSF1R(2), EPOR(1), GP1BA(3), GP5(3), IL11RA(1), IL1B(1), IL4(1), IL5RA(2), ITGA1(1), ITGA2(5), ITGA5(1), ITGAM(2), TPO(5)	437592	44	33	44	16	12	26	2	0	4	0.020	0.48
26	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	5	PRKCA(3), RELA(2)	22334	5	4	5	1	1	2	0	1	1	0.020	0.48
27	ST_GRANULE_CELL_ SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	24	APC(7), CREB3(1), EPHB2(3), MAPK1(1), MAPK8IP3(3)	99871	15	14	15	1	3	8	1	2	1	0.021	0.48
28	ST_DICTYOSTELIUM_ DISCOIDEUM_CAMP_ CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	32	ETFA(2), ITPR1(1), ITPR2(5), ITPR3(3), MAPK1(1), MAPK3(1), PAK1(1), PIK3C2G(1), RIPK3(1)	201122	16	16	16	7	5	5	0	0	6	0.022	0.48
29	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	33	APC(7), EGFR(2), ITPR1(1), ITPR2(5), ITPR3(3), KCNJ9(3), MAPK1(1), RAF1(1)	187506	23	21	23	5	6	10	2	1	4	0.024	0.48
30	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	16	CD3E(1), IL4(1)	3543	2	2	2	0	0	2	0	0	0	0.025	0.48
31	HSA04720_LONG_TERM_ POTENTIATION	Genes involved in long-term potentiation	59	ADCY8(8), ARAF(1), CAMK2A(2), CAMK2D(1), CAMK4(1), EP300(4), ITPR1(1), ITPR2(5), ITPR3(3), MAPK1(1), MAPK3(1), PLCB4(3), PPP3CC(1), PRKCA(3), RAF1(1), RPS6KA2(2)	352535	38	31	38	12	12	18	1	2	5	0.025	0.48
32	HSA00760_NICOTINATE_ AND_NICOTINAMIDE_ METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	22	ENPP3(3), NNT(4), NT5C2(1), NT5C3(2), NT5E(1)	71425	11	11	11	2	2	6	2	0	1	0.025	0.48
33	HSA00592_ALPHA_LINOLENIC_ ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	15	PLA2G4A(4)	15172	4	4	4	2	1	2	0	1	0	0.028	0.51
34	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	12	APC(7), CDH1(1), EP300(4), MAPK3(1)	103093	13	13	13	2	0	10	1	1	1	0.029	0.51
35	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	20	PPP3CC(1), PRKCA(3)	31711	4	4	4	0	0	1	0	1	2	0.029	0.51
36	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	6	LDLR(3)	11475	3	3	3	0	1	1	0	1	0	0.030	0.51
37	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	17	PRKCA(3)	15591	3	3	3	1	0	1	0	1	1	0.036	0.57
38	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	4	PRKCA(3)	15591	3	3	3	1	0	1	0	1	1	0.036	0.57
39	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	21	MAPK1(1), MAPK3(1), PRKCA(3), PTK2(2), SMPD2(3)	64456	10	9	10	1	3	4	1	1	1	0.037	0.57
40	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	6	EP300(4)	15128	4	4	4	2	0	4	0	0	0	0.037	0.57
41	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	21	COL4A3(2), COL4A4(6), COL4A6(2), F12(1), F5(5), FGG(1), SERPING1(2)	169868	19	17	19	9	5	10	0	0	4	0.039	0.59
42	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	18	JAK2(3), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	55018	8	7	8	1	2	3	0	2	1	0.040	0.59
43	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	9	CDC25B(2), PRKCA(3)	32755	5	5	5	1	0	2	1	1	1	0.044	0.60
44	HSA04730_LONG_TERM_ DEPRESSION	Genes involved in long-term depression	68	ARAF(1), CACNA1A(6), CRHR1(3), GNAS(2), GUCY2C(3), GUCY2D(1), ITPR1(1), ITPR2(5), ITPR3(3), LYN(1), MAPK1(1), MAPK3(1), NOS3(1), PLA2G4A(4), PLCB4(3), PPP2R2A(1), PRKCA(3), RAF1(1)	418920	41	31	41	12	8	22	1	4	6	0.045	0.60
45	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	11	ACE2(2), CMA1(1), COL4A3(2), COL4A4(6), COL4A6(2)	89017	13	12	13	6	4	8	0	0	1	0.047	0.60
46	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	15	NTRK1(5), SOS1(3)	55847	8	8	8	1	0	6	0	1	1	0.047	0.60
47	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	124	ACTN3(2), ASH1L(5), CDK4(1), EPB41L1(2), INADL(5), LLGL1(1), LLGL2(2), MAGI1(3), MPDZ(2), MYH1(9), MYH10(2), MYH11(6), MYH14(4), MYH4(11), MYH6(8), MYH7B(2), OCLN(1), PPP2R2A(1), PRKCA(3), PRKCE(2), PRKCZ(1), SPTAN1(2), SYMPK(2), TJAP1(4), YES1(2)	971164	83	49	83	33	26	35	6	9	7	0.047	0.60
48	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	10	COL4A3(2), COL4A4(6), COL4A6(2)	65233	10	9	10	6	4	5	0	0	1	0.047	0.60
49	PROSTAGLANDIN_AND_ LEUKOTRIENE_METABOLISM		31	PLA2G4A(4), PRDX2(1), TPO(5)	64806	10	10	10	4	3	5	0	1	1	0.048	0.60
50	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	41	CD3E(1), MAP3K1(4), MAPK3(1), PPP3CC(1), PRKCA(3), RAF1(1), RASA1(2), RELA(2), SOS1(3)	177584	18	17	18	3	4	8	0	1	5	0.049	0.60
51	HSA01040_POLYUNSATURATED_ FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	13	HSD17B12(1)	3178	1	1	1	0	0	0	0	0	1	0.052	0.63
52	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	7	CD36(1)	6029	1	1	1	1	0	0	1	0	0	0.053	0.63
53	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	20	IL16(4), IL4(1)	25265	5	5	5	0	3	2	0	0	0	0.055	0.64
54	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	22	IRAK1(4), MAP3K1(4), MAP3K14(1), MYD88(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	148769	15	13	15	5	6	4	1	2	2	0.057	0.65
55	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	12	GABRA3(3)	10755	3	3	3	0	0	3	0	0	0	0.059	0.65
56	HSA00680_METHANE_ METABOLISM	Genes involved in methane metabolism	10	TPO(5)	28868	5	5	5	1	1	3	0	0	1	0.061	0.65
57	HSA00940_PHENYLPROPANOID_ BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	7	TPO(5)	28868	5	5	5	1	1	3	0	0	1	0.061	0.65
58	HSA00401_NOVOBIOCIN_ BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	3	TAT(3)	10582	3	3	3	1	1	2	0	0	0	0.062	0.66
59	STARCH_AND_SUCROSE_ METABOLISM		44	AGL(2), ENPP3(3), GANAB(4), GPI(3), GYS1(1), GYS2(2), HK1(3), MGAM(7), PGM1(1), UGT1A7(1), UGT2B15(2)	273958	29	24	29	10	9	13	1	2	4	0.065	0.68
60	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	6	PER1(4)	18600	4	3	4	0	1	3	0	0	0	0.066	0.68
61	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	15	EP300(4), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	58982	9	8	9	4	2	6	0	1	0	0.069	0.70
62	PANTOTHENATE_AND_ COA_BIOSYNTHESIS		12	DPYS(2), ENPP3(3), PANK3(1), PANK4(2)	59870	8	8	8	0	2	4	0	2	0	0.071	0.70
63	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	28	CXCR3(1), IL12RB2(2), IL4(1)	19709	4	4	4	1	1	2	0	0	1	0.075	0.71
64	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	12	MAPK1(1), PRKCA(3)	28033	4	4	4	0	0	2	0	1	1	0.077	0.71
65	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	7	LDLR(3)	17745	3	3	3	0	1	1	0	1	0	0.078	0.71
66	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	12	EP300(4)	19942	4	4	4	2	0	4	0	0	0	0.079	0.71
67	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	9	GABRA3(3), PRKCE(2)	23876	5	5	5	0	1	4	0	0	0	0.083	0.71
68	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	124	ABLIM1(2), ABLIM3(2), DPYSL5(4), EPHA2(2), EPHA6(7), EPHB2(3), MAPK1(1), MAPK3(1), MET(2), NFAT5(1), NRP1(4), PAK1(1), PLXNA1(2), PLXNA2(1), PLXNB1(1), PLXNC1(2), PPP3CC(1), PTK2(2), RASA1(2), ROBO3(3), SEMA3B(2), SEMA3F(1), SEMA3G(1), SEMA4F(3), SEMA6B(1), SEMA6D(4), SEMA7A(3), SLIT1(4), SRGAP3(3)	720382	66	44	66	25	18	33	6	3	6	0.084	0.71
69	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	43	EGFR(2), MAP2K6(2), MAP3K1(4), MAP3K14(1), MAPK1(1), MAPK3(1), PRKCA(3), PRKCE(2), RAF1(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	226611	22	20	22	7	7	9	0	2	4	0.086	0.71
70	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	7	AKAP13(4)	22005	4	4	4	1	1	2	0	1	0	0.086	0.71
71	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	13	F5(5), FGG(1)	41492	6	6	6	2	1	3	0	0	2	0.087	0.71
72	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	17	IL12RB2(2), IL4(1)	16272	3	3	3	1	0	2	0	0	1	0.089	0.71
73	APOPTOSIS_GENMAPP		42	BAK1(1), MAP3K1(4), MAP3K14(1), PARP1(2), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	136283	13	12	13	6	5	4	0	1	3	0.091	0.71
74	GLUCOCORTICOID_MINERALOCORTICOID_ METABOLISM		8	CYP11B2(3)	26788	3	3	3	1	0	1	0	2	0	0.092	0.71
75	ST_INTERFERON_GAMMA_ PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	9	JAK2(3), PTPRU(3), STAT1(1)	54370	7	6	7	1	0	5	0	1	1	0.093	0.71
76	SIG_CHEMOTAXIS	Genes related to chemotaxis	44	ARHGEF11(7), BTK(2), ITPR1(1), ITPR2(5), ITPR3(3), MYLK(1), PAK1(1), RHO(1), WASL(1)	286271	22	18	22	6	8	8	1	0	5	0.094	0.71
77	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	18	PPP3CC(1), PRKCA(3)	52885	4	4	4	0	0	1	0	1	2	0.095	0.71
78	BIOGENIC_AMINE_SYNTHESIS		15	DDC(3), PAH(2)	30650	5	5	5	0	3	2	0	0	0	0.096	0.71
79	GALACTOSE_METABOLISM		24	GALT(1), GANAB(4), HK1(3), MGAM(7), PFKP(2), PGM1(1)	162622	18	16	18	5	5	10	0	1	2	0.099	0.71
80	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	6	EP300(4), MAPK1(1), MAPK3(1)	45524	6	6	6	2	0	6	0	0	0	0.100	0.71
81	BLOOD_CLOTTING_CASCADE		20	F12(1), F5(5), FGG(1), LPA(6)	121106	13	12	13	5	2	8	0	0	3	0.10	0.71
82	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	14	MAPK1(1), MAPK3(1), PRKCA(3), RAF1(1), RELA(2)	56915	8	7	8	2	2	4	0	1	1	0.10	0.71
83	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	8	IL4(1)	1601	1	1	1	0	0	1	0	0	0	0.10	0.71
84	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	16	IL4(1)	1601	1	1	1	0	0	1	0	0	0	0.10	0.71
85	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	29	IL4(1)	1601	1	1	1	0	0	1	0	0	0	0.10	0.71
86	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	15	IL4(1)	1601	1	1	1	0	0	1	0	0	0	0.10	0.71
87	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	6	NRG2(2), PRKCA(3)	39039	5	5	5	0	0	3	0	1	1	0.10	0.71
88	ST_WNT_CA2_CYCLIC_ GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	19	CAMK2A(2), CAMK2D(1), ITPR1(1), ITPR2(5), ITPR3(3), NFAT5(1), PDE6A(2), PDE6B(1)	178205	16	16	16	5	7	5	1	0	3	0.11	0.71
89	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	11	JAK2(3), PTPRU(3)	46377	6	6	6	1	0	4	0	1	1	0.11	0.71
90	METHANE_METABOLISM		13	PRDX2(1), TPO(5)	43333	6	6	6	2	2	3	0	0	1	0.11	0.71
91	STILBENE_COUMARINE_ AND_LIGNIN_BIOSYNTHESIS		10	PRDX2(1), TPO(5)	43333	6	6	6	2	2	3	0	0	1	0.11	0.71
92	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	9	JAK2(3), PIAS1(1), PTPRU(3)	48492	7	7	7	1	1	4	0	1	1	0.11	0.71
93	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	4	PRKCA(3)	23703	3	3	3	1	0	1	0	1	1	0.11	0.72
94	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	27	ITPR1(1), ITPR2(5), ITPR3(3), NFKBIL2(5), PLD3(1)	177118	15	15	15	5	6	4	1	1	3	0.11	0.73
95	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	17	GNAS(2), PRKAG2(2)	22804	4	4	4	2	1	2	0	0	1	0.11	0.73
96	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	33	BLNK(1), BTK(2), LYN(1), MAP3K1(4), MAPK3(1), PPP3CC(1), PRKCA(3), RAF1(1), SOS1(3)	172852	17	17	17	2	3	9	0	1	4	0.12	0.74
97	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	52	BAG4(1), CFLAR(1), DFFB(1), MAP3K1(4), MAP3K14(1), PRKDC(4), PTK2(2), RASA1(2), RELA(2), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(1)	331822	23	21	23	7	8	8	0	1	6	0.12	0.74
98	HSA04912_GNRH_SIGNALING_ PATHWAY	Genes involved in GnRH signaling pathway	90	ADCY4(3), ADCY5(2), ADCY8(8), CACNA1D(1), CACNA1F(3), CAMK2A(2), CAMK2D(1), EGFR(2), GNAS(2), ITPR1(1), ITPR2(5), ITPR3(3), MAP2K6(2), MAP3K1(4), MAPK1(1), MAPK3(1), PLA2G4A(4), PLCB4(3), PRKCA(3), RAF1(1), SOS1(3)	637990	55	48	55	23	18	24	3	3	7	0.12	0.74
99	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	15	CSF2RB(4), JAK2(3), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	106400	13	13	13	3	3	8	0	1	1	0.12	0.74
100	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	17	CD3E(1)	1942	1	1	1	0	0	1	0	0	0	0.12	0.74
101	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	13	CD3E(1)	1942	1	1	1	0	0	1	0	0	0	0.12	0.74
102	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	6	CD3E(1)	1942	1	1	1	0	0	1	0	0	0	0.12	0.74
103	TCRMOLECULE	T Cell Receptor and CD3 Complex	3	CD3E(1)	1942	1	1	1	0	0	1	0	0	0	0.12	0.74
104	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	7	JAK2(3)	29641	3	3	3	0	0	1	0	1	1	0.14	0.78
105	ST_INTERLEUKIN_13_ PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	7	JAK2(3)	29641	3	3	3	0	0	1	0	1	1	0.14	0.78
106	HSA04630_JAK_STAT_ SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	150	CSF2RB(4), EP300(4), EPOR(1), IFNA16(2), IL10RA(1), IL11RA(1), IL12RB2(2), IL21R(2), IL22(1), IL22RA2(1), IL4(1), IL5RA(2), JAK2(3), PIAS1(1), PIAS4(1), PIK3R5(4), PIM1(2), SOS1(3), STAT1(1), STAT5B(1), TPO(5)	500427	43	31	43	16	10	23	1	2	7	0.14	0.78
107	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	11	GNAS(2)	9709	2	2	2	2	0	2	0	0	0	0.14	0.78
108	PHENYLALANINE_METABOLISM		22	ALDH3A1(1), AOC2(1), DDC(3), PRDX2(1), TAT(3), TPO(5)	129129	14	13	14	5	4	7	1	0	2	0.14	0.78
109	HSA04540_GAP_JUNCTION	Genes involved in gap junction	87	ADCY4(3), ADCY5(2), ADCY8(8), EGFR(2), GNAS(2), GUCY2C(3), GUCY2D(1), ITPR1(1), ITPR2(5), ITPR3(3), MAP2K5(1), MAPK1(1), MAPK3(1), PDGFRB(5), PLCB4(3), PRKCA(3), RAF1(1), SOS1(3), TUBB2C(1), TUBB4(3)	559927	52	41	52	18	12	27	4	3	6	0.14	0.79
110	SELENOAMINO_ACID_ METABOLISM		12	MARS(1), MAT1A(1), PAPSS2(1), SCLY(1)	29022	4	3	4	1	1	2	0	1	0	0.15	0.79
111	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	22	JAK2(3), MAP3K1(4), MAPK3(1), RAF1(1), SOS1(3), STAT1(1), STAT5B(1)	118969	14	14	14	2	3	8	0	1	2	0.15	0.79
112	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	9	HK1(3), PGM1(1)	56996	4	4	4	0	4	0	0	0	0	0.15	0.79
113	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	12	MYLK(1), PPP1R12B(1), PRKCA(3)	42126	5	5	5	2	1	2	0	1	1	0.15	0.79
114	HSA00534_HEPARAN_ SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	18	EXT2(1), EXTL1(1), NDST2(3)	38400	5	5	5	3	0	4	0	0	1	0.15	0.79
115	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	11	EPOR(1), JAK2(3), RELA(2)	62158	6	4	6	1	1	2	0	1	2	0.15	0.79
116	HSA04370_VEGF_SIGNALING_ PATHWAY	Genes involved in VEGF signaling pathway	68	MAPK1(1), MAPK3(1), NFAT5(1), NOS3(1), PIK3R5(4), PLA2G4A(4), PPP3CC(1), PRKCA(3), PTK2(2), RAF1(1)	190351	19	18	19	8	4	10	0	2	3	0.16	0.79
117	LYSINE_DEGRADATION		31	ALDH3A1(1), DLST(1), DOT1L(2), GCDH(1)	137776	5	5	5	2	0	0	3	1	1	0.16	0.79
118	HSA00271_METHIONINE_ METABOLISM	Genes involved in methionine metabolism	17	DNMT1(3), MARS(1), MAT1A(1), TAT(3)	64416	8	8	8	2	1	6	0	1	0	0.16	0.79
119	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	20	CD3E(1), GNAS(2), PTPRC(4)	54419	7	7	7	4	1	5	1	0	0	0.16	0.79
120	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	20	CD3E(1), GNAS(2), PTPRC(4)	54419	7	7	7	4	1	5	1	0	0	0.16	0.79
121	1_2_DICHLOROETHANE_ DEGRADATION		8	ALDH3A1(1)	7017	1	1	1	0	0	0	0	0	1	0.16	0.79
122	ASCORBATE_AND_ALDARATE_ METABOLISM		8	ALDH3A1(1)	7017	1	1	1	0	0	0	0	0	1	0.16	0.79
123	HSA00053_ASCORBATE_ AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	9	ALDH3A1(1)	7017	1	1	1	0	0	0	0	0	1	0.16	0.79
124	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	21	EP300(4), IL1B(1), MAP2K6(2), MAP3K14(1), MYD88(1), RELA(2)	95951	11	10	11	7	3	6	0	0	2	0.16	0.79
125	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	18	PICALM(2), PPP3CC(1), SYNJ2(1)	43525	4	4	4	1	0	2	0	0	2	0.16	0.79
126	HSA02010_ABC_TRANSPORTERS_ GENERAL	Genes involved in ABC transporters - general	39	ABCA13(16), ABCA7(1), ABCB1(9), ABCC1(4), ABCC10(1), ABCC2(2), ABCC5(1), ABCC8(6), ABCC9(5), ABCG4(1), ABCG8(5)	538742	51	41	51	23	13	28	3	3	4	0.16	0.80
127	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	11	CAPN1(2)	9989	2	2	2	0	1	1	0	0	0	0.17	0.82
128	HSA00150_ANDROGEN_ AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	54	ARSE(2), CYP11B1(5), CYP11B2(3), CYP19A1(3), HSD17B12(1), UGT1A7(1), UGT2B15(2), WBSCR22(1)	192556	18	17	18	2	7	7	1	2	1	0.17	0.83
129	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	23	MAPK1(1), MAPK3(1), PIK3C2G(1), PRKCA(3), PTK2(2), RAF1(1), RELA(2)	98923	11	9	11	7	3	5	0	1	2	0.18	0.83
130	IFNGPATHWAY	IFN gamma signaling pathway	6	JAK2(3), STAT1(1)	37634	4	4	4	0	0	2	0	1	1	0.18	0.83
131	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	13	IL10RA(1), IL22(1), IL22RA2(1), JAK2(3), STAT1(1), STAT5B(1)	77011	8	8	8	3	1	4	0	1	2	0.18	0.85
132	HSA00400_PHENYLALANINE_ TYROSINE_AND_TRYPTOPHAN_ BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	9	PAH(2), TAT(3)	38582	5	5	5	1	3	2	0	0	0	0.19	0.86
133	ANDROGEN_AND_ESTROGEN_ METABOLISM		30	ARSE(2), CYP11B1(5), CYP11B2(3), UGT1A7(1), UGT2B15(2)	148732	13	13	13	1	5	5	1	2	0	0.19	0.86
134	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	28	MAP3K1(4), MAPK1(1), MAPK3(1), PAK1(1), PRKCA(3), RAF1(1), SOS1(3)	124133	14	14	14	3	4	7	0	1	2	0.19	0.86
135	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	21	BRCA1(5), CDC25B(2), EP300(4), PRKDC(4)	153217	15	14	15	4	2	8	1	1	3	0.19	0.86
136	SA_DIACYLGLYCEROL_ SIGNALING	DAG (diacylglycerol) signaling activity	9	PDE1A(2)	8439	2	2	2	0	1	1	0	0	0	0.20	0.89
137	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	16	ADAM12(2), EGFR(2), PRKCA(3), RELA(2)	81809	9	8	9	3	2	4	1	1	1	0.20	0.89
138	NICOTINATE_AND_NICOTINAMIDE_ METABOLISM		13	ENPP3(3), NNT(4), NT5E(1)	63666	8	8	8	2	2	5	0	0	1	0.20	0.89
139	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	10	IL1B(1), IL4(1), IL5RA(2)	24551	4	4	4	1	1	3	0	0	0	0.20	0.89
140	APOPTOSIS_KEGG		48	CASP10(2), DFFB(1), NTRK1(5), PTPN13(2), SFRS2IP(1), TNFRSF1A(2), TNFRSF1B(1)	144217	14	14	14	2	2	8	0	2	2	0.21	0.89
141	HSA00565_ETHER_LIPID_ METABOLISM	Genes involved in ether lipid metabolism	30	AGPAT4(1), ENPP2(3), PLA2G4A(4)	69005	8	8	8	8	1	5	0	1	1	0.21	0.89
142	METHIONINE_METABOLISM		12	DNMT1(3), MARS(1), MAT1A(1)	45467	5	5	5	1	0	4	0	1	0	0.21	0.89
143	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	37	CAMK2A(2), CAMK2D(1), JAK2(3), MAPK1(1), MAPK3(1), MYLK(1), PRKCA(3), RAF1(1), SOS1(3), STAT1(1)	169961	17	17	17	6	4	9	0	2	2	0.21	0.89
144	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	10	GSR(2), RELA(2)	53442	4	3	4	1	1	1	0	2	0	0.21	0.89
145	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	49	CD36(1), EP300(4), HSD17B4(1), MAPK1(1), MAPK3(1), NCOR1(4), NCOR2(3), PRKCA(3), RELA(2), STAT5B(1)	202545	21	18	21	8	5	12	1	1	2	0.21	0.89
146	HSA00520_NUCLEOTIDE_ SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	6	GALT(1)	3300	1	1	1	0	0	1	0	0	0	0.21	0.89
147	NUCLEOTIDE_SUGARS_ METABOLISM		5	GALT(1)	3300	1	1	1	0	0	1	0	0	0	0.21	0.89
148	OVARIAN_INFERTILITY_ GENES		24	CDK4(1), INHA(3), MLH1(2), MSH5(1), NCOR1(4), ZP2(3)	152158	14	13	14	1	4	6	2	0	2	0.22	0.90
149	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	18	F2RL3(1), PPP1R12B(1), PRKCA(3)	58556	5	5	5	1	2	1	0	1	1	0.22	0.90
150	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	32	IRAK1(4), MAP2K6(2), MAP3K1(4), MAP3K14(1), MYD88(1), RELA(2), TLR9(1), TOLLIP(1)	201970	16	14	16	6	6	5	1	1	3	0.22	0.91
151	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	29	EGFR(2), GNAS(2), MAPK1(1), MAPK3(1), MKNK2(1), RAF1(1), SOS1(3)	112885	11	11	11	5	2	9	0	0	0	0.23	0.91
152	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	13	EP300(4), NOS3(1)	45322	5	5	5	3	0	5	0	0	0	0.23	0.91
153	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	21	MAP3K1(4), MAPK1(1), MAPK3(1), RAF1(1), RELA(2), TNFRSF1A(2)	103899	11	10	11	3	5	5	0	0	1	0.23	0.91
154	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	18	EP300(4), HDAC2(1), PPP3CC(1), PRKCA(3)	121933	9	9	9	5	0	5	0	2	2	0.23	0.91
155	ST_T_CELL_SIGNAL_ TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	42	EPHB2(3), GRAP2(1), MAPK1(1), NFAT5(1), NFKBIL2(5), PAK1(1), PTPRC(4), RAF1(1), SOS1(3)	230873	20	16	20	5	7	9	2	2	0	0.24	0.93
156	SMOOTH_MUSCLE_CONTRACTION		133	ADCY4(3), ADCY5(2), ADCY8(8), ATP2A3(2), CAMK2A(2), CAMK2D(1), CREB3(1), CRHR1(3), GRK4(1), IL1B(1), ITPR1(1), ITPR2(5), ITPR3(3), NOS3(1), PRKCA(3), PRKCE(2), PRKCZ(1), RGS6(3), TNXB(12), USP5(1)	964021	56	36	56	22	23	23	2	2	6	0.24	0.93
157	HSA00670_ONE_CARBON_ POOL_BY_FOLATE	Genes involved in one carbon pool by folate	16	ALDH1L1(2), MTHFD1L(1)	28439	3	3	3	1	0	2	0	1	0	0.24	0.93
158	ONE_CARBON_POOL_ BY_FOLATE		15	ALDH1L1(2), MTHFD1L(1)	28439	3	3	3	1	0	2	0	1	0	0.24	0.93
159	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	10	CR1(2), FCGR2B(2), ITGAL(2), PTPRC(4)	98937	10	10	10	4	4	5	1	0	0	0.24	0.93
160	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	34	GNAS(2), MAPK3(1), PPP3CC(1), PRKCA(3), RAF1(1)	87694	8	8	8	3	1	4	0	1	2	0.24	0.93
161	SA_MMP_CYTOKINE_ CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	15	FCGR3A(2), IL1B(1), SELL(1), TNFRSF1A(2), TNFRSF1B(1)	76010	7	7	7	1	3	2	0	1	1	0.24	0.93
162	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	27	MAP3K1(4), PPP3CC(1), RELA(2)	80041	7	6	7	3	3	2	0	0	2	0.24	0.93
163	HSA04710_CIRCADIAN_ RHYTHM	Genes involved in circadian rhythm	11	PER1(4), PER3(2)	56477	6	5	6	3	2	3	0	1	0	0.25	0.95
164	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	18	IL4(1), MAP3K1(4), RELA(2)	60131	7	5	7	3	3	3	0	0	1	0.26	0.95
165	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	18	MAP3K1(4), MAP3K14(1), RELA(2), TNFRSF1B(1)	103223	8	7	8	4	3	2	0	1	2	0.26	0.95
166	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	26	MAP3K1(4), MAPK3(1), PRKCA(3), RAF1(1), RASA1(2), SOS1(3), STAT1(1)	201694	15	15	15	2	3	7	0	1	4	0.26	0.95
167	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	36	MAP2K6(2), MAP3K1(4), MAPK1(1), MAPK3(1), PAK1(1), PIK3C2G(1), PPP3CC(1), RAF1(1), RELA(2)	218790	14	13	14	7	5	5	0	0	4	0.26	0.95
168	G_PROTEIN_SIGNALING		87	ADCY4(3), ADCY5(2), ADCY8(8), AKAP11(4), GNAL(1), ITPR1(1), PDE1A(2), PDE4A(1), PDE4C(1), PPP3CC(1), PRKCA(3), PRKCE(2), PRKCZ(1), PRKD3(2), USP5(1)	504036	33	28	33	12	8	13	1	5	6	0.26	0.95
169	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	10	CD3E(1), PTPRC(4)	44710	5	5	5	2	1	3	1	0	0	0.26	0.95
170	SA_PROGRAMMED_CELL_ DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	12	BAK1(1)	8259	1	1	1	0	1	0	0	0	0	0.26	0.95
171	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	31	IL1B(1), IRAK1(4), MAP2K6(2), MAP3K1(4), MAP3K14(1), MYD88(1), RELA(2), TOLLIP(1)	230805	16	14	16	8	7	4	1	1	3	0.27	0.95
172	HSA04320_DORSO_VENTRAL_ AXIS_FORMATION	Genes involved in dorso-ventral axis formation	25	EGFR(2), MAPK1(1), MAPK3(1), NOTCH1(6), NOTCH2(2), NOTCH3(3), PIWIL3(2), RAF1(1), SOS1(3)	245545	21	19	21	5	3	14	1	0	3	0.27	0.95
173	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	21	BTK(2), EPHB2(3), F2RL3(1), MAP2K5(1), MAPK1(1), PLD3(1), PTK2(2), RAF1(1)	127431	12	9	12	2	4	5	0	1	2	0.27	0.95
174	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	26	CAMK2A(2), CAMK2D(1), GNAS(2), MAPK1(1), MAPK3(1), PRKCA(3), SOS1(3)	122035	13	13	13	4	3	8	0	1	1	0.27	0.95
175	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	9	PRKCE(2)	13121	2	2	2	0	1	1	0	0	0	0.27	0.96
176	RIBOFLAVIN_METABOLISM		10	ACPP(1), ENPP3(3)	30603	4	4	4	0	2	2	0	0	0	0.27	0.96
177	HSA04670_LEUKOCYTE_ TRANSENDOTHELIAL_ MIGRATION	Genes involved in Leukocyte transendothelial migration	108	ACTN3(2), CD99(1), CDH5(1), CTNND1(2), CYBB(2), GRLF1(2), ITGAL(2), ITGAM(2), OCLN(1), PIK3R5(4), PRKCA(3), PTK2(2), VCL(2)	312677	26	20	26	20	6	13	0	3	4	0.29	0.99
178	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	8	SOS1(3)	21786	3	3	3	1	0	3	0	0	0	0.29	0.99
179	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	26	APC(7), DVL1(1), IRAK1(4), MYD88(1), RELA(2), TOLLIP(1)	193783	16	15	16	2	5	6	2	2	1	0.29	0.99
180	GLYCINE_SERINE_AND_ THREONINE_METABOLISM		37	AGXT2(3), AOC2(1), DLD(1), GLDC(3), SARDH(3)	177000	11	11	11	4	3	5	3	0	0	0.29	0.99
181	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	35	ARHGEF11(7), LPA(6), MAP3K1(4), NFKBIL2(5), PLD3(1), PTK2(2), TBXA2R(1)	312077	26	20	26	7	9	12	2	1	2	0.29	0.99
182	SIG_BCR_SIGNALING_ PATHWAY	Members of the BCR signaling pathway	45	BLNK(1), BTK(2), CD19(1), CD22(4), INPP5D(4), ITPR1(1), ITPR2(5), ITPR3(3), LYN(1), MAPK1(1), MAPK3(1), PPP3CC(1), PTPRC(4), RAF1(1), SOS1(3)	386812	33	29	33	9	9	16	2	1	5	0.30	0.99
183	SIG_PIP3_SIGNALING_ IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	32	BTK(2), CD19(1), ITPR1(1), ITPR2(5), ITPR3(3), LYN(1), PTPRC(4), RPS6KA2(2)	232605	19	18	19	7	5	8	1	1	4	0.30	0.99
184	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	13	MAP3K1(4), MAP3K14(1), RELA(2)	92143	7	6	7	4	3	2	0	0	2	0.30	0.99
185	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	13	APC(7), DVL1(1), EP300(4)	127040	12	12	12	2	1	8	1	1	1	0.30	0.99
186	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	16	MAP2K6(2), MAP3K1(4), MAPK1(1), MAPK3(1), RELA(2)	100137	10	9	10	3	3	5	0	0	2	0.30	0.99
187	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	7	JAK2(3), MAPK1(1), MAPK3(1)	60037	5	5	5	0	0	3	0	1	1	0.30	1.00
188	HSA04150_MTOR_SIGNALING_ PATHWAY	Genes involved in mTOR signaling pathway	43	EIF4B(2), MAPK1(1), MAPK3(1), PIK3R5(4), RPS6KA2(2), TSC2(2), ULK2(1)	133941	13	13	13	4	3	7	0	1	2	0.31	1.00
189	HSA00521_STREPTOMYCIN_ BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	10	HK1(3), PGM1(1)	85505	4	4	4	1	4	0	0	0	0	0.31	1.00
190	STREPTOMYCIN_BIOSYNTHESIS		8	HK1(3), PGM1(1)	85505	4	4	4	1	4	0	0	0	0	0.31	1.00
191	HSA04070_PHOSPHATIDYLINOSITOL_ SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	72	INPP5B(2), INPP5D(4), ITPR1(1), ITPR2(5), ITPR3(3), PI4KA(3), PIK3C2A(1), PIK3C2B(5), PIK3C2G(1), PIK3R5(4), PIP5K1C(1), PLCB4(3), PLCE1(6), PRKCA(3), SYNJ2(1)	557262	43	34	43	13	9	23	1	3	7	0.31	1.00
192	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	32	APC(7), BMPR1A(2), DVL1(1)	119877	10	10	10	0	2	4	1	2	1	0.32	1.00
193	HSA05110_CHOLERA_ INFECTION	Genes involved in cholera - infection	39	ATP6V0A1(3), ATP6V0A2(5), ATP6V1G3(1), ATP6V1H(1), ERO1L(1), GNAS(2), PRKCA(3)	178951	16	13	16	4	3	9	0	1	3	0.32	1.00
194	HSA04740_OLFACTORY_ TRANSDUCTION	Genes involved in olfactory transduction	29	CAMK2A(2), CAMK2D(1), CLCA4(2), CNGB1(3), GNAL(1)	139603	9	9	9	2	5	2	0	0	2	0.32	1.00
195	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	17	EGFR(2), MAPK1(1), MAPK3(1), RAF1(1), RASA1(2), SOS1(3)	102839	10	10	10	2	2	6	0	0	2	0.32	1.00
196	HSA00512_O_GLYCAN_ BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	30	B4GALT5(1), GALNT2(2), GALNT6(3), GALNT7(2), GALNT8(1), GALNTL1(2), OGT(2)	156141	13	13	13	3	1	11	0	0	1	0.33	1.00
197	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	15	EP300(4), STAT5B(1)	47677	5	5	5	3	0	5	0	0	0	0.33	1.00
198	CHONDROITIN		8	XYLT2(1)	10142	1	1	1	0	1	0	0	0	0	0.33	1.00
199	HEPARAN_SULFATE_ BIOSYNTHESIS		8	XYLT2(1)	10142	1	1	1	0	1	0	0	0	0	0.33	1.00
200	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	33	EGFR(2), MAP3K1(4), MAPK1(1), MAPK3(1), PAK1(1), PRKCA(3), PTK2(2), RAF1(1), SOS1(3)	185598	18	17	18	5	6	9	0	1	2	0.33	1.00
201	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	7	CDC25B(2)	26740	2	2	2	1	0	1	1	0	0	0.33	1.00
202	HSA00052_GALACTOSE_ METABOLISM	Genes involved in galactose metabolism	32	GALT(1), HK1(3), MGAM(7), PFKP(2), PGM1(1)	158349	14	12	14	5	5	7	0	1	1	0.33	1.00
203	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	12	GNAS(2), PLCE1(6)	83615	8	8	8	3	1	6	0	1	0	0.34	1.00
204	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	36	BTK(2), LYN(1), MAP3K1(4), MAPK1(1), MAPK3(1), PLA2G4A(4), PPP3CC(1), RAF1(1), SOS1(3)	196160	18	17	18	4	4	10	0	1	3	0.34	1.00
205	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	6	LDLR(3)	38263	3	3	3	0	1	1	0	1	0	0.35	1.00
206	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	20	GNAS(2), MAPK1(1), MAPK3(1), PIK3C2G(1), PPP1R12B(1), PRKCA(3), PTK2(2), RAF1(1)	132211	12	11	12	8	3	6	0	1	2	0.36	1.00
207	HSA00600_SPHINGOLIPID_ METABOLISM	Genes involved in sphingolipid metabolism	36	ARSE(2), NEU1(2), SMPD2(3), SMPD3(2), UGCG(1)	181332	10	8	10	0	6	2	1	1	0	0.36	1.00
208	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	26	EGFR(2), MAP3K1(4), MAPK3(1), PRKCA(3), RAF1(1), RASA1(2), SOS1(3), STAT1(1)	239569	17	17	17	3	4	8	0	1	4	0.37	1.00
209	ST_TUMOR_NECROSIS_ FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	28	BAG4(1), CFLAR(1), NFKBIL2(5), RALBP1(1), TNFRSF1A(2), TNFRSF1B(1)	187906	11	11	11	2	3	3	1	3	1	0.37	1.00
210	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	5	NOTCH1(6)	69622	6	5	6	1	0	5	0	0	1	0.37	1.00
211	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	21	MAPK3(1), RAF1(1), RALBP1(1), RELA(2)	59969	5	4	5	3	2	2	0	1	0	0.37	1.00
212	HSA00360_PHENYLALANINE_ METABOLISM	Genes involved in phenylalanine metabolism	27	ALDH3A1(1), AOC2(1), DDC(3), TAT(3), TPO(5)	143409	13	12	13	7	3	7	1	0	2	0.38	1.00
213	SA_B_CELL_RECEPTOR_ COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	23	BLNK(1), LYN(1), MAP3K1(4), MAPK1(1), MAPK3(1), MAPK8IP3(3), SOS1(3)	144410	14	14	14	2	4	9	0	0	1	0.38	1.00
214	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	39	MAP2K6(2), MAP3K1(4), MAPKAPK5(1), MAX(1), PLA2G4A(4), STAT1(1)	165215	13	13	13	5	3	6	0	1	3	0.38	1.00
215	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	22	CSF2RB(4)	38474	4	4	4	2	2	2	0	0	0	0.38	1.00
216	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	22	EIF4A1(1), EIF4G3(2), MAPK1(1), MAPK3(1), PRKCA(3)	112777	8	8	8	2	0	5	0	1	2	0.38	1.00
217	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	22	BTK(2), LYN(1), PFKP(2), PRKCE(2), PRKCZ(1), RAB5A(1)	88235	9	8	9	1	2	6	0	0	1	0.40	1.00
218	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	6	GNAS(2)	16178	2	2	2	2	0	2	0	0	0	0.40	1.00
219	HSA04210_APOPTOSIS	Genes involved in apoptosis	81	CAPN1(2), CASP10(2), CFLAR(1), CSF2RB(4), DFFB(1), IL1B(1), IRAK1(4), MAP3K14(1), MYD88(1), NTRK1(5), PIK3R5(4), PPP3CC(1), RELA(2), TNFRSF1A(2)	382065	31	26	31	13	9	15	1	2	4	0.40	1.00
220	HSA00430_TAURINE_ AND_HYPOTAURINE_ METABOLISM	Genes involved in taurine and hypotaurine metabolism	6	CSAD(1)	13358	1	1	1	0	1	0	0	0	0	0.40	1.00
221	ST_ERK1_ERK2_MAPK_ PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	28	CREB3(1), MAPK1(1), MAPK3(1), MKNK2(1), RPS6KA2(2), SOS1(3)	125067	9	9	9	1	0	8	0	1	0	0.41	1.00
222	NITROGEN_METABOLISM		20	CA6(3)	48048	3	3	3	0	1	1	1	0	0	0.41	1.00
223	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	27	CASP10(2), CFLAR(1), DFFB(1), MAP3K1(4), PAK1(1), PRKDC(4), PTPN13(2), SPTAN1(2)	230379	17	15	17	4	6	8	0	0	3	0.41	1.00
224	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	22	CDK4(1), MAPK1(1), MAPK3(1), PAK1(1), RAF1(1), RELA(2)	87189	7	6	7	2	4	3	0	0	0	0.41	1.00
225	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	32	MAPK1(1), MAPK3(1), MAPK8IP3(3), MAPKAPK5(1), NFKBIL2(5)	135907	11	11	11	3	4	4	1	1	1	0.42	1.00
226	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	13	ACTN3(2), PTK2(2), VCL(2)	106692	6	6	6	2	2	2	0	2	0	0.43	1.00
227	ATP_SYNTHESIS		21	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	166301	7	6	7	0	2	2	0	0	3	0.43	1.00
228	FLAGELLAR_ASSEMBLY		21	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	166301	7	6	7	0	2	2	0	0	3	0.43	1.00
229	PHOTOSYNTHESIS		22	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	166301	7	6	7	0	2	2	0	0	3	0.43	1.00
230	TYPE_III_SECRETION_ SYSTEM		21	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	166301	7	6	7	0	2	2	0	0	3	0.43	1.00
231	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	25	MAP2K6(2), MAP3K1(4), MAP3K14(1), RELA(2), TNFRSF1A(2)	186672	11	10	11	6	4	4	0	0	3	0.43	1.00
232	GLYOXYLATE_AND_DICARBOXYLATE_ METABOLISM		12	ACO1(1), GRHPR(1), MTHFD1L(1)	60672	3	3	3	0	2	0	0	1	0	0.43	1.00
233	HSA00750_VITAMIN_ B6_METABOLISM	Genes involved in vitamin B6 metabolism	5	PDXK(1)	15525	1	1	1	1	1	0	0	0	0	0.45	1.00
234	HSA04512_ECM_RECEPTOR_ INTERACTION	Genes involved in ECM-receptor interaction	79	AGRN(1), CD36(1), CHAD(1), COL11A2(6), COL4A4(6), COL4A6(2), COL5A3(7), FNDC3A(1), GP1BA(3), GP5(3), HSPG2(4), ITGA1(1), ITGA2(5), ITGA5(1), ITGA7(2), ITGB4(2), ITGB6(1), LAMA1(7), LAMB1(5), LAMB2(3), LAMB4(3), TNC(5), TNXB(12)	1218973	82	55	82	28	24	43	2	5	8	0.45	1.00
235	HSA00630_GLYOXYLATE_ AND_DICARBOXYLATE_ METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	13	ACO1(1), GRHPR(1), MTHFD1L(1)	63326	3	3	3	0	2	0	0	1	0	0.45	1.00
236	GLYCOSPHINGOLIPID_ METABOLISM		23	ARSE(2), NEU1(2), SMPD2(3), UGCG(1)	165743	8	6	8	0	5	1	1	1	0	0.45	1.00
237	BENZOATE_DEGRADATION_ VIA_COA_LIGATION		10	GCDH(1)	37433	1	1	1	2	0	0	1	0	0	0.45	1.00
238	SA_REG_CASCADE_OF_ CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	13	CDK4(1)	14436	1	1	1	0	1	0	0	0	0	0.46	1.00
239	HSA00770_PANTOTHENATE_ AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	16	BCAT2(2), DPYS(2), ENPP3(3), PANK3(1), PANK4(2)	138477	10	9	10	0	3	5	0	2	0	0.47	1.00
240	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	9	ACACA(2), PRKAG2(2)	41713	4	4	4	2	1	2	0	0	1	0.47	1.00
241	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	15	MAPK1(1), MAPK3(1), RAF1(1), SOS1(3)	63146	6	6	6	1	1	5	0	0	0	0.47	1.00
242	PENTOSE_AND_GLUCURONATE_ INTERCONVERSIONS		18	UGT1A7(1), UGT2B15(2)	52538	3	3	3	0	1	1	1	0	0	0.47	1.00
243	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	11	CD3E(1), ITGAL(2), PTPRC(4)	80883	7	7	7	4	2	4	1	0	0	0.47	1.00
244	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	11	CD3E(1), ITGAL(2), PTPRC(4)	80883	7	7	7	4	2	4	1	0	0	0.47	1.00
245	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	17	MAPK1(1), MAPK3(1), NTRK1(5)	92976	7	7	7	1	0	5	0	1	1	0.48	1.00
246	HSA04612_ANTIGEN_ PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	73	IFNA16(2), KLRC3(1), LGMN(1), TAPBP(2)	251611	6	6	6	0	0	2	3	0	1	0.48	1.00
247	HSA00310_LYSINE_ DEGRADATION	Genes involved in lysine degradation	46	ALDH3A1(1), DLST(1), DOT1L(2), GCDH(1), HSD17B4(1)	224760	6	6	6	4	1	0	3	1	1	0.48	1.00
248	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	9	ITGA1(1), LYN(1)	28183	2	2	2	0	0	1	0	0	1	0.48	1.00
249	HSA01031_GLYCAN_ STRUCTURES_BIOSYNTHESIS_ 2	Genes involved in glycan structures - biosynthesis 2	59	B4GALT3(1), FUT6(2), PIGO(2), PIGQ(1), ST3GAL4(1), UGCG(1)	144109	8	8	8	3	2	3	1	2	0	0.49	1.00
250	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	21	EIF4A1(1), EIF4B(2), EIF4G3(2), TSC2(2)	99694	7	7	7	2	1	4	0	0	2	0.49	1.00
251	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	9	MAP3K14(1), RELA(2)	45442	3	2	3	3	1	1	0	0	1	0.50	1.00
252	HSA00530_AMINOSUGARS_ METABOLISM	Genes involved in aminosugars metabolism	29	AMDHD2(1), CHIA(3), CHIT1(3), GFPT2(2), GNE(1), HK1(3)	193616	13	11	13	7	6	6	0	0	1	0.50	1.00
253	TYROSINE_METABOLISM		32	ADH6(1), ALDH3A1(1), AOC2(1), DDC(3), TAT(3), TPO(5)	167633	14	13	14	4	3	8	1	0	2	0.50	1.00
254	GANGLIOSIDE_BIOSYNTHESIS		8	ST3GAL4(1)	10400	1	1	1	1	0	1	0	0	0	0.51	1.00
255	HSA00260_GLYCINE_ SERINE_AND_THREONINE_ METABOLISM	Genes involved in glycine, serine and threonine metabolism	45	AGXT2(3), AOC2(1), DLD(1), GLDC(3), SARDH(3), SARS2(1)	241655	12	12	12	4	3	6	3	0	0	0.51	1.00
256	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	9	CDC25B(2)	42795	2	2	2	1	0	1	1	0	0	0.51	1.00
257	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	10	BAG4(1), TNFRSF1A(2), TNFRSF1B(1)	79887	4	4	4	0	1	1	0	1	1	0.52	1.00
258	HSA04012_ERBB_SIGNALING_ PATHWAY	Genes involved in ErbB signaling pathway	83	ARAF(1), CAMK2A(2), CAMK2D(1), EGFR(2), ERBB3(2), MAPK1(1), MAPK3(1), NRG2(2), PAK1(1), PIK3R5(4), PRKCA(3), PTK2(2), RAF1(1), SOS1(3), STAT5B(1)	345073	27	23	27	9	8	15	0	1	3	0.52	1.00
259	WNT_SIGNALING	Wnt signaling genes	59	APC(7), DVL1(1), DVL3(1), FZD2(2), LDLR(3), PPP2R5C(2), PRKCA(3), PRKCE(2), PRKCZ(1), WNT7A(2)	305380	24	19	24	4	6	12	1	3	2	0.52	1.00
260	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	94	ADCY4(3), ADCY5(2), ADCY8(8), CAMK2A(2), CAMK2D(1), CREB3(1), DVL1(1), DVL3(1), EP300(4), FZD2(2), GNAS(2), MAPK1(1), MAPK3(1), PLCB4(3), PRKCA(3), RAF1(1), WNT7A(2), WNT8A(1), WNT9A(1)	551900	40	30	40	16	12	22	2	2	2	0.53	1.00
261	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	17	GNAS(2), NOS3(1), RELA(2)	56669	5	4	5	4	1	4	0	0	0	0.54	1.00
262	SIG_IL4RECEPTOR_ IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	27	MAPK1(1), MAPK3(1), RAF1(1), SOS1(3)	66840	6	6	6	1	1	5	0	0	0	0.54	1.00
263	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	16	MAPK1(1), MAPK3(1), PTK2(2), SOS1(3)	80309	7	7	7	1	1	6	0	0	0	0.54	1.00
264	ST_FAS_SIGNALING_ PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	58	BAK1(1), BTK(2), CAD(2), CASP10(2), EGFR(2), EPHB2(3), FAIM2(1), MAP3K1(4), MAPK1(1), MAPK8IP3(3), MET(2), NFAT5(1), NFKBIL2(5), PTPN13(2), RALBP1(1)	437898	32	24	32	6	9	14	2	4	3	0.54	1.00
265	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	12	APC(7), DVL1(1), NOTCH1(6)	181534	14	13	14	1	1	9	1	1	2	0.54	1.00
266	PENTOSE_PHOSPHATE_ PATHWAY		23	GPI(3), PFKP(2), PGM1(1), RBKS(1)	110501	7	6	7	0	2	3	0	0	2	0.55	1.00
267	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	12	F13A1(1), FGG(1)	42266	2	2	2	1	0	1	0	0	1	0.55	1.00
268	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	10	DFFB(1), HMGB1(1), TOP2A(2), TOP2B(2)	76164	6	6	6	2	1	4	0	1	0	0.56	1.00
269	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	15	CDK4(1)	18622	1	1	1	0	1	0	0	0	0	0.56	1.00
270	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	10	EGFR(2), MAP3K1(4), NCOR2(3)	141099	9	9	9	3	5	3	0	0	1	0.56	1.00
271	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	20	MAPK3(1), RAF1(1), RASA1(2), SOS1(3)	110028	7	7	7	1	1	4	0	0	2	0.56	1.00
272	HSA00040_PENTOSE_ AND_GLUCURONATE_ INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	25	UGT1A7(1), UGT2B15(2)	60362	3	3	3	0	1	1	1	0	0	0.56	1.00
273	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	19	EPOR(1), JAK2(3), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	145153	10	10	10	1	1	6	0	1	2	0.56	1.00
274	HSA00730_THIAMINE_ METABOLISM	Genes involved in thiamine metabolism	8	NFS1(1)	11610	1	1	1	1	0	1	0	0	0	0.56	1.00
275	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	6	CFLAR(1)	11610	1	1	1	0	0	1	0	0	0	0.57	1.00
276	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	22	CDK4(1), RBL1(4)	89470	5	5	5	0	1	2	1	0	1	0.58	1.00
277	HSA04330_NOTCH_SIGNALING_ PATHWAY	Genes involved in Notch signaling pathway	41	CTBP1(1), CTBP2(1), DLL3(2), DTX2(1), DVL1(1), DVL3(1), EP300(4), HDAC2(1), NCOR2(3), NCSTN(3), NOTCH1(6), NOTCH2(2), NOTCH3(3)	416361	29	24	29	7	5	20	1	1	2	0.58	1.00
278	HSA00252_ALANINE_ AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	33	AARS2(4), AGXT2(3), CAD(2), CRAT(1), DLAT(2), DLD(1), NARS2(3), PC(1)	273237	17	14	17	3	3	9	3	1	1	0.58	1.00
279	LIMONENE_AND_PINENE_ DEGRADATION		12	ALDH3A1(1)	37815	1	1	1	2	0	0	0	0	1	0.58	1.00
280	INOSITOL_PHOSPHATE_ METABOLISM		22	PIK3C2A(1), PIK3C2B(5), PIK3C2G(1), PLCB4(3)	146394	10	10	10	5	1	6	1	0	2	0.58	1.00
281	HSA00910_NITROGEN_ METABOLISM	Genes involved in nitrogen metabolism	23	CA6(3)	62956	3	3	3	0	1	1	1	0	0	0.58	1.00
282	BUTANOATE_METABOLISM		27	AACS(2), ALDH3A1(1)	45478	3	3	3	3	0	2	0	0	1	0.59	1.00
283	HSA00450_SELENOAMINO_ ACID_METABOLISM	Genes involved in selenoamino acid metabolism	26	MARS(1), MAT1A(1), PAPSS2(1), SCLY(1), WBSCR22(1)	86532	5	4	5	2	2	2	0	1	0	0.59	1.00
284	HSA03022_BASAL_TRANSCRIPTION_ FACTORS	Genes involved in basal transcription factors	33	GTF2H1(1), GTF2IRD1(2), TAF1(7), TAF2(3)	260875	13	13	13	1	2	5	1	2	3	0.59	1.00
285	APOPTOSIS		68	BAK1(1), CASP10(2), DFFB(1), HELLS(1), IRF2(1), MAP3K1(4), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	214440	15	12	15	5	6	7	0	1	1	0.59	1.00
286	HSA04010_MAPK_SIGNALING_ PATHWAY	Genes involved in MAPK signaling pathway	239	ACVR1C(1), CACNA1A(6), CACNA1D(1), CACNA1F(3), CACNA1G(4), CACNA1H(1), CACNA2D2(2), CACNA2D4(1), CACNB4(2), CDC25B(2), ECSIT(1), EGFR(2), FLNA(4), FLNB(3), IL1B(1), MAP2K5(1), MAP2K6(2), MAP3K1(4), MAP3K12(1), MAP3K14(1), MAP4K3(1), MAPK1(1), MAPK3(1), MAPK8IP3(3), MAPKAPK5(1), MAX(1), MKNK2(1), NTRK1(5), PAK1(1), PDGFRB(5), PLA2G4A(4), PPP3CC(1), PRKCA(3), RAF1(1), RASA1(2), RASA2(2), RASGRF2(2), RPS6KA2(2), RPS6KA4(2), SOS1(3), TAOK2(2), TNFRSF1A(2)	1508760	89	53	89	29	17	46	4	8	14	0.59	1.00
287	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	4	BMPR1A(2)	59383	2	2	2	1	1	0	0	1	0	0.59	1.00
288	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	4	C3(1), C9(2)	45118	3	3	3	1	1	1	0	0	1	0.59	1.00
289	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	20	BRCA1(5), RAD1(1), RAD50(3), RAD51(1)	158688	10	9	10	1	0	7	0	1	2	0.59	1.00
290	STEROID_BIOSYNTHESIS		9	HSD17B4(1)	20128	1	1	1	0	1	0	0	0	0	0.59	1.00
291	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	14	DYRK1A(3)	36554	3	3	3	2	0	3	0	0	0	0.60	1.00
292	PROSTAGLANDIN_SYNTHESIS_ REGULATION		29	ANXA5(2), PLA2G4A(4)	93707	6	6	6	3	1	3	0	1	1	0.60	1.00
293	ALKALOID_BIOSYNTHESIS_ II		5	AOC2(1)	64563	1	1	1	2	0	0	1	0	0	0.60	1.00
294	HSA04140_REGULATION_ OF_AUTOPHAGY	Genes involved in regulation of autophagy	29	IFNA16(2), ULK2(1)	75466	3	3	3	0	1	1	1	0	0	0.60	1.00
295	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	7	CREM(1), GNAS(2)	33851	3	3	3	2	1	2	0	0	0	0.61	1.00
296	HSA00480_GLUTATHIONE_ METABOLISM	Genes involved in glutathione metabolism	37	GSR(2)	124672	2	2	2	1	0	0	0	2	0	0.62	1.00
297	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	15	EGFR(2), POLR2A(2), PRKCA(3)	156794	7	7	7	4	1	3	0	2	1	0.62	1.00
298	HSA00061_FATTY_ACID_ BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	5	ACACA(2)	29803	2	2	2	2	0	2	0	0	0	0.62	1.00
299	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	12	MAPK1(1), MAPK3(1), RAF1(1)	34581	3	3	3	1	1	2	0	0	0	0.62	1.00
300	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	84	MAP2K5(1), MAP2K6(2), MAP3K1(4), MAP3K11(1), MAP3K12(1), MAP3K14(1), MAP4K3(1), MAPK1(1), MAPK3(1), MAPKAPK5(1), MAX(1), MKNK2(1), PAK1(1), RAF1(1), RELA(2), RPS6KA2(2), RPS6KA4(2), STAT1(1)	558471	25	18	25	10	5	13	0	1	6	0.62	1.00
301	CELL_CYCLE_KEGG		81	CDC25B(2), CDH1(1), CDK4(1), EP300(4), HDAC2(1), ORC3L(1), PRKDC(4), RBL1(4), TBC1D8(2)	320587	20	19	20	10	3	11	3	1	2	0.62	1.00
302	HSA04130_SNARE_INTERACTIONS_ IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	35	BNIP1(1), STX5(1)	58901	2	2	2	0	1	0	0	1	0	0.62	1.00
303	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	18	MAPK3(1), RAF1(1), SOS1(3)	56510	5	5	5	1	1	4	0	0	0	0.64	1.00
304	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	21	CD5(1), IL4(1), TLR9(1)	39715	3	3	3	2	0	3	0	0	0	0.64	1.00
305	HSA00280_VALINE_ LEUCINE_AND_ISOLEUCINE_ DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	44	ALDH3A1(1), BCAT2(2), DBT(1), DLD(1), HSD17B4(1)	143986	6	6	6	4	3	1	0	0	2	0.64	1.00
306	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	15	CDK4(1)	23334	1	1	1	0	1	0	0	0	0	0.65	1.00
307	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	12	TNFRSF1A(2), TNFRSF1B(1)	61738	3	3	3	0	1	1	0	1	0	0.65	1.00
308	HISTIDINE_METABOLISM		24	ALDH3A1(1), AOC2(1), DDC(3)	99457	5	5	5	2	1	2	1	0	1	0.65	1.00
309	HSA00030_PENTOSE_ PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	26	GPI(3), PFKP(2), PGM1(1), RBKS(1)	130054	7	6	7	1	2	3	0	0	2	0.66	1.00
310	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	10	CD3E(1), ITGAL(2)	38115	3	3	3	2	1	2	0	0	0	0.66	1.00
311	PEPTIDE_GPCRS		65	AVPR2(2), CXCR3(1), GALT(1), NPY1R(3), NTSR2(2)	125666	9	9	9	2	2	7	0	0	0	0.66	1.00
312	HSA00440_AMINOPHOSPHONATE_ METABOLISM	Genes involved in aminophosphonate metabolism	16	WBSCR22(1)	30916	1	1	1	1	1	0	0	0	0	0.67	1.00
313	ST_B_CELL_ANTIGEN_ RECEPTOR	B cell receptors bind antigens and promote B cell activation.	38	BLNK(1), BTK(2), CD19(1), EPHB2(3), LYN(1), MAPK1(1), NFAT5(1), NFKBIL2(5), RAF1(1), SOS1(3)	243003	19	16	19	5	4	11	1	2	1	0.67	1.00
314	ST_WNT_BETA_CATENIN_ PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	31	ANKRD6(3), APC(7), DVL1(1), FSTL1(1), LRP1(8), MVP(1), SENP2(1)	319998	22	19	20	3	3	15	2	1	1	0.67	1.00
315	HSA05120_EPITHELIAL_ CELL_SIGNALING_IN_ HELICOBACTER_PYLORI_ INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	66	ATP6V0A1(3), ATP6V0A2(5), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1), EGFR(2), LYN(1), MAP3K14(1), MET(2), PAK1(1), RELA(2)	360966	21	17	21	6	7	8	1	1	4	0.67	1.00
316	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	28	BAG4(1), DFFB(1), MADD(2), MAP3K1(4), PAK1(1), PRKDC(4), SPTAN1(2), TNFRSF1A(2)	303523	17	16	17	5	7	7	0	0	3	0.67	1.00
317	HSA00591_LINOLEIC_ ACID_METABOLISM	Genes involved in linoleic acid metabolism	30	PLA2G4A(4)	67803	4	4	4	6	1	2	0	1	0	0.68	1.00
318	HSA00562_INOSITOL_ PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	46	INPP5B(2), PI4KA(3), PIP5K1C(1), PLCB4(3), PLCE1(6), SYNJ2(1)	241884	16	15	16	3	2	12	1	1	0	0.68	1.00
319	HSA00051_FRUCTOSE_ AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	40	GMPPA(1), HK1(3), PFKP(2)	152373	6	5	6	0	4	2	0	0	0	0.68	1.00
320	HSA04120_UBIQUITIN_ MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	39	ANAPC4(2), CUL2(2), SMURF2(1), UBA1(1)	116083	6	6	6	1	0	4	1	0	1	0.68	1.00
321	HSA00641_3_CHLOROACRYLIC_ ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	15	ADH6(1), ALDH3A1(1)	59986	2	2	2	0	0	1	0	0	1	0.68	1.00
322	HSA04520_ADHERENS_ JUNCTION	Genes involved in adherens junction	71	ACTN3(2), ACVR1C(1), CDH1(1), CTNND1(2), EGFR(2), EP300(4), FARP2(1), INSR(2), MAPK1(1), MAPK3(1), MET(2), PTPRF(4), PTPRJ(2), PVRL1(4), PVRL3(1), SORBS1(4), VCL(2), WASF3(1), WASL(1), YES1(2)	724442	40	30	40	16	4	26	2	6	2	0.68	1.00
323	HSA04340_HEDGEHOG_ SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	55	CSNK1G1(2), GLI1(1), STK36(4), WNT7A(2), WNT8A(1), WNT9A(1)	172860	11	9	11	2	1	9	0	0	1	0.69	1.00
324	HSA00564_GLYCEROPHOSPHOLIPID_ METABOLISM	Genes involved in glycerophospholipid metabolism	64	AGPAT4(1), CRLS1(1), GPAM(4), PLA2G4A(4)	171416	10	10	10	10	2	4	1	1	2	0.69	1.00
325	O_GLYCAN_BIOSYNTHESIS		14	GALNT2(2), GALNT6(3), GALNT7(2), GALNT8(1), ST3GAL4(1)	121550	9	9	9	2	1	7	0	0	1	0.69	1.00
326	ST_DIFFERENTIATION_ PATHWAY_IN_PC12_ CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	39	CREB3(1), MAP1B(4), MAPK1(1), MAPK3(1), MAPK8IP3(3), NTRK1(5), OPN1LW(1), PIK3C2G(1)	223790	17	17	17	8	5	9	0	1	2	0.69	1.00
327	HSA04614_RENIN_ANGIOTENSIN_ SYSTEM	Genes involved in renin-angiotensin system	17	ACE2(2), CMA1(1), CTSA(1), CTSG(2), THOP1(1)	90353	7	7	7	2	2	5	0	0	0	0.70	1.00
328	SMALL_LIGAND_GPCRS		14	DNMT1(3), TBXA2R(1)	61959	4	4	4	1	0	4	0	0	0	0.70	1.00
329	CYSTEINE_METABOLISM		7	LDHB(1), LDHC(1)	25514	2	2	2	0	0	2	0	0	0	0.70	1.00
330	HSA00272_CYSTEINE_ METABOLISM	Genes involved in cysteine metabolism	16	LDHB(1), LDHC(1)	25514	2	2	2	0	0	2	0	0	0	0.70	1.00
331	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	7	EGFR(2), RAB5A(1)	41225	3	3	3	1	1	2	0	0	0	0.71	1.00
332	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	12	CASP10(2)	27270	2	2	2	1	0	2	0	0	0	0.71	1.00
333	STRIATED_MUSCLE_ CONTRACTION		33	ACTN3(2), MYBPC3(1), MYH6(8), MYOM1(2), NEB(9), TNNT3(1)	353138	23	20	23	15	8	11	1	1	2	0.72	1.00
334	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	22	POLD1(1), REV3L(4)	79977	5	4	5	3	1	3	1	0	0	0.72	1.00
335	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	21	JAK2(3), MAPK3(1), RAF1(1), SOS1(3)	120867	8	8	8	1	1	5	0	1	1	0.72	1.00
336	CITRATE_CYCLE_TCA_ CYCLE		20	ACO1(1), DLD(1), DLST(1), IDH3A(1), IDH3B(1), PC(1)	123154	6	6	6	0	3	2	0	1	0	0.72	1.00
337	STATIN_PATHWAY_PHARMGKB		18	LDLR(3), LRP1(8)	151522	11	10	9	2	2	7	1	1	0	0.72	1.00
338	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	14	PAK1(1), WASL(1)	35640	2	2	2	0	1	1	0	0	0	0.73	1.00
339	DNA_POLYMERASE		6	POLD1(1)	36216	1	1	1	1	1	0	0	0	0	0.73	1.00
340	REDUCTIVE_CARBOXYLATE_ CYCLE_CO2_FIXATION		9	ACO1(1)	34692	1	1	1	0	1	0	0	0	0	0.73	1.00
341	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	25	EIF2B1(1), EIF2B3(1), EIF2B4(1), FLT4(1), NOS3(1), PRKCA(3), PTK2(2)	175316	10	9	10	6	1	6	0	1	2	0.74	1.00
342	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	5	EGFR(2), ERBB3(2)	66028	4	3	4	1	1	2	0	0	1	0.74	1.00
343	INTEGRIN_MEDIATED_ CELL_ADHESION_KEGG		87	CAPN1(2), CAPN11(1), CAPN3(3), CAPN5(3), DOCK1(3), ITGA2(5), ITGA5(1), ITGA7(2), ITGAL(2), ITGAM(2), ITGB4(2), ITGB6(1), MAP2K6(2), PAK1(1), PTK2(2), RAPGEF1(2), RHO(1), SORBS1(4), SOS1(3), TLN1(3), VCL(2)	675454	47	34	47	17	13	27	4	1	2	0.74	1.00
344	HSA04110_CELL_CYCLE	Genes involved in cell cycle	108	ANAPC4(2), CDC25B(2), CDK4(1), EP300(4), HDAC2(1), ORC3L(1), PRKDC(4), RBL1(4), SMC1A(2)	378629	21	18	21	9	5	10	3	1	2	0.75	1.00
345	ARGININE_AND_PROLINE_ METABOLISM		42	ALDH3A1(1), AOC2(1), NOS3(1), SMS(2)	120204	5	4	5	3	0	3	1	0	1	0.75	1.00
346	VALINE_LEUCINE_AND_ ISOLEUCINE_BIOSYNTHESIS		7	LARS(1), LARS2(2)	48873	3	3	3	0	0	3	0	0	0	0.75	1.00
347	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	19	BAK1(1), DFFB(1)	39039	2	2	2	0	1	1	0	0	0	0.76	1.00
348	HSA04620_TOLL_LIKE_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in Toll-like receptor signaling pathway	100	IFNA16(2), IL1B(1), IRAK1(4), MAP2K6(2), MAPK1(1), MAPK3(1), MYD88(1), PIK3R5(4), RELA(2), STAT1(1), TLR9(1), TOLLIP(1)	297494	21	19	21	9	6	10	2	1	2	0.76	1.00
349	HSA00740_RIBOFLAVIN_ METABOLISM	Genes involved in riboflavin metabolism	16	ACP6(1), ACPP(1), ENPP3(3)	66513	5	5	5	0	2	3	0	0	0	0.76	1.00
350	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	16	MAPK1(1), MAPK3(1), SOS1(3)	79795	5	5	5	1	0	5	0	0	0	0.76	1.00
351	HSA00960_ALKALOID_ BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	18	AOC2(1)	93844	1	1	1	5	0	0	1	0	0	0.77	1.00
352	FRUCTOSE_AND_MANNOSE_ METABOLISM		25	GMPPA(1), HK1(3), PFKP(2)	177610	6	5	6	1	4	2	0	0	0	0.77	1.00
353	HSA00410_BETA_ALANINE_ METABOLISM	Genes involved in beta-alanine metabolism	25	ALDH3A1(1), AOC2(1), DPYS(2), SMS(2)	131399	6	5	6	4	1	3	1	0	1	0.77	1.00
354	HSA00251_GLUTAMATE_ METABOLISM	Genes involved in glutamate metabolism	30	CAD(2), GFPT2(2), GSR(2)	193922	6	6	6	2	0	3	0	2	1	0.77	1.00
355	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	11	CREB3(1), MAPK1(1), RAF1(1)	47083	3	3	3	1	1	2	0	0	0	0.77	1.00
356	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	43	DLAT(2), DLD(1), GPI(3), HK1(3), LDHB(1), LDHC(1), PC(1), PFKP(2), PGK1(2)	263510	16	14	16	1	6	8	1	0	1	0.77	1.00
357	HSA00190_OXIDATIVE_ PHOSPHORYLATION	Genes involved in oxidative phosphorylation	113	ATP4A(2), ATP6V0A1(3), ATP6V0A2(5), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1), CYC1(2)	413775	16	14	16	6	4	8	0	0	4	0.78	1.00
358	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	15	CASP10(2), DFFB(1)	52440	3	3	3	1	0	3	0	0	0	0.78	1.00
359	PHENYLALANINE_TYROSINE_ AND_TRYPTOPHAN_BIOSYNTHESIS		9	PAH(2), TAT(3)	95872	5	5	5	1	3	2	0	0	0	0.78	1.00
360	HSA00561_GLYCEROLIPID_ METABOLISM	Genes involved in glycerolipid metabolism	54	ADH6(1), AGPAT4(1), ALDH3A1(1), GPAM(4), LIPF(1), PNLIPRP1(3), PNLIPRP2(1)	285472	12	12	12	7	2	5	1	1	3	0.78	1.00
361	HSA00380_TRYPTOPHAN_ METABOLISM	Genes involved in tryptophan metabolism	58	ALDH3A1(1), AOC2(1), DDC(3), GCDH(1), HSD17B4(1), WARS(1), WBSCR22(1)	240108	9	9	9	8	4	2	2	0	1	0.78	1.00
362	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	13	PTK2(2)	31172	2	2	2	4	1	1	0	0	0	0.78	1.00
363	KREBS_TCA_CYCLE		30	DLAT(2), DLD(1), DLST(1), IDH3A(1), IDH3B(1), PC(1)	145351	7	7	7	2	2	3	1	1	0	0.78	1.00
364	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	18	CSF1R(2), DDX20(1), HDAC2(1), NCOR2(3), RBL1(4)	156588	11	11	11	1	2	6	1	1	1	0.78	1.00
365	PORPHYRIN_AND_CHLOROPHYLL_ METABOLISM		26	CP(1), UGT1A7(1), UGT2B15(2)	112573	4	4	4	1	1	2	1	0	0	0.79	1.00
366	ST_TYPE_I_INTERFERON_ PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	8	PTPRU(3), STAT1(1)	61202	4	3	4	2	0	4	0	0	0	0.79	1.00
367	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	13	C3(1), ITGAL(2)	60771	3	3	3	3	2	1	0	0	0	0.79	1.00
368	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	25	INSR(2), JAK2(3), MAPK1(1), MAPK3(1), PRKCA(3), RAF1(1), SLC2A4(1), SOS1(3), STAT5B(1)	339345	16	16	16	1	1	10	0	3	2	0.79	1.00
369	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	25	BRCA1(5), EP300(4), HDAC2(1), NCOR2(3), NR0B1(1), POLR2A(2)	326870	16	15	16	4	3	8	0	3	2	0.79	1.00
370	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	18	NTRK1(5), WASF3(1), WASL(1)	125978	7	7	7	1	0	5	0	1	1	0.79	1.00
371	HSA04610_COMPLEMENT_ AND_COAGULATION_ CASCADES	Genes involved in complement and coagulation cascades	66	C1QA(2), C2(2), C3(1), C9(2), CFB(1), CR1(2), F12(1), F13A1(1), F5(5), FGG(1), MASP2(1), SERPIND1(1), SERPING1(2)	534322	22	20	22	9	5	11	1	0	5	0.79	1.00
372	IRINOTECAN_PATHWAY_ PHARMGKB		17	ABCC1(4), ABCC2(2), UGT1A7(1)	102004	7	7	7	1	3	4	0	0	0	0.79	1.00
373	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	22	MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	83668	6	6	6	1	1	5	0	0	0	0.79	1.00
374	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	11	IL4(1)	22279	1	1	1	0	0	1	0	0	0	0.80	1.00
375	BILE_ACID_BIOSYNTHESIS		27	ADH6(1), ALDH3A1(1)	75508	2	2	2	0	0	1	0	0	1	0.80	1.00
376	HSA00920_SULFUR_ METABOLISM	Genes involved in sulfur metabolism	14	PAPSS2(1)	41953	1	1	1	0	1	0	0	0	0	0.80	1.00
377	SULFUR_METABOLISM		9	PAPSS2(1)	41953	1	1	1	0	1	0	0	0	0	0.80	1.00
378	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	10	DFFB(1), GZMA(3)	62047	4	4	4	0	2	2	0	0	0	0.80	1.00
379	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	22	CAP1(1), GNAS(2), MAPK1(1), MAPK3(1)	102882	5	5	5	2	0	4	0	1	0	0.80	1.00
380	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	14	RELA(2)	34331	2	1	2	2	1	1	0	0	0	0.80	1.00
381	HSA04350_TGF_BETA_ SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	88	ACVR1C(1), ACVRL1(2), BMPR1A(2), EP300(4), INHBC(1), MAPK1(1), MAPK3(1), NODAL(2), PPP2R2A(1), RBL1(4), SMURF2(1), ZFYVE16(1)	395453	21	21	21	3	3	11	2	3	2	0.81	1.00
382	HSA00220_UREA_CYCLE_ AND_METABOLISM_OF_ AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	29	ALDH3A1(1), AOC2(1), SMS(2)	139826	4	3	4	3	0	2	1	0	1	0.81	1.00
383	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	35	CREB3(1), MAP2K6(2), MAPK1(1), MAPKAPK5(1), MKNK2(1)	197538	6	6	6	2	0	4	0	0	2	0.81	1.00
384	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	10	ITGAL(2), ITGAM(2), SELL(1)	73305	5	5	5	5	2	3	0	0	0	0.81	1.00
385	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	8	ITGAL(2), ITGAM(2), SELL(1)	73305	5	5	5	5	2	3	0	0	0	0.81	1.00
386	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	14	CAMK2A(2), CAMK2D(1), CAMK4(1), CAMKK1(2)	150511	6	6	6	4	3	2	1	0	0	0.81	1.00
387	NUCLEAR_RECEPTORS		40	ALK(6), NR0B1(1)	203944	7	7	7	2	2	3	2	0	0	0.81	1.00
388	CIRCADIAN_EXERCISE		39	HERPUD1(1), PER1(4)	73634	5	4	5	1	2	3	0	0	0	0.82	1.00
389	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	15	MAP3K14(1), RELA(2)	77690	3	2	3	3	1	1	0	0	1	0.82	1.00
390	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	21	MAP3K1(4), MYLK(1), PAK1(1), PPP1R12B(1), RALBP1(1), TRIO(3)	175024	11	10	11	6	4	5	0	1	1	0.82	1.00
391	CALCIUM_REGULATION_ IN_CARDIAC_CELLS		132	ADCY4(3), ADCY5(2), ADCY8(8), ATP1B2(1), ATP2A3(2), ATP2B1(4), ATP2B2(4), CACNA1A(6), CACNA1D(1), CAMK2A(2), CAMK2D(1), CAMK4(1), CHRM1(1), GJB1(1), GRK4(1), ITPR1(1), ITPR2(5), ITPR3(3), PEA15(1), PRKCA(3), PRKCE(2), PRKCZ(1), RGS6(3), SLC8A3(5), USP5(1)	1199693	63	39	63	20	23	28	1	4	7	0.82	1.00
392	OXIDATIVE_PHOSPHORYLATION		59	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	305179	7	6	7	2	2	2	0	0	3	0.82	1.00
393	ACE_INHIBITOR_PATHWAY_ PHARMGKB		8	NOS3(1)	27524	1	1	1	1	0	1	0	0	0	0.84	1.00
394	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	34	CFLAR(1), MAPK1(1), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	145668	8	8	8	1	1	7	0	0	0	0.84	1.00
395	HSA04514_CELL_ADHESION_ MOLECULES	Genes involved in cell adhesion molecules (CAMs)	126	CD22(4), CD99(1), CDH1(1), CDH3(1), CDH5(1), CNTN1(7), ICAM3(1), ITGAL(2), ITGAM(2), MAG(1), NLGN2(1), NRCAM(3), OCLN(1), PTPRC(4), PTPRF(4), PVRL1(4), PVRL3(1), SELL(1)	750908	40	26	40	18	8	24	5	1	2	0.84	1.00
396	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	48	ADCY4(3), ADCY8(8), CACNA1A(6), GNAS(2), ITPR3(3), PDE1A(2)	351707	24	19	24	7	7	12	1	2	2	0.84	1.00
397	HSA04660_T_CELL_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in T cell receptor signaling pathway	91	CD3E(1), CDK4(1), GRAP2(1), IL4(1), MAP3K14(1), NFAT5(1), PAK1(1), PIK3R5(4), PPP3CC(1), PTPRC(4), SOS1(3)	314051	19	19	19	7	5	10	1	0	3	0.84	1.00
398	UREA_CYCLE_AND_METABOLISM_ OF_AMINO_GROUPS		19	SMS(2)	38583	2	1	2	0	0	2	0	0	0	0.84	1.00
399	HSA04650_NATURAL_ KILLER_CELL_MEDIATED_ CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	123	ARAF(1), FCGR3A(2), IFNA16(2), ITGAL(2), KLRC3(1), MAPK1(1), MAPK3(1), NFAT5(1), PAK1(1), PIK3R5(4), PPP3CC(1), PRKCA(3), RAF1(1), SOS1(3)	435333	24	24	24	9	5	13	1	1	4	0.84	1.00
400	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	7	CDC25B(2)	97726	2	2	2	1	0	1	1	0	0	0.84	1.00
401	GLYCEROPHOSPHOLIPID_ METABOLISM		49	AGPAT4(1), PLA2G4A(4)	125346	5	5	5	4	1	2	0	1	1	0.84	1.00
402	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	15	INSR(2), MAGI1(3)	113829	5	5	5	1	2	2	0	1	0	0.85	1.00
403	HSA00720_REDUCTIVE_ CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	11	ACLY(1), ACO1(1), ACSS1(2)	115416	4	4	4	1	2	1	0	1	0	0.85	1.00
404	HSA01030_GLYCAN_ STRUCTURES_BIOSYNTHESIS_ 1	Genes involved in glycan structures - biosynthesis 1	108	B4GALT3(1), B4GALT5(1), CHPF(1), EXT2(1), EXTL1(1), GALNT2(2), GALNT6(3), GALNT7(2), GALNT8(1), GALNTL1(2), GANAB(4), MAN1A1(3), MAN2A1(4), NDST2(3), OGT(2), ST3GAL4(1), XYLT2(1)	544899	33	31	33	11	6	23	0	1	3	0.85	1.00
405	HSA00626_NAPHTHALENE_ AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	18	WBSCR22(1)	49207	1	1	1	1	1	0	0	0	0	0.85	1.00
406	TRYPTOPHAN_METABOLISM		52	ALDH3A1(1), AOC2(1), CYP19A1(3), CYP2B6(1), CYP2F1(1), DDC(3), GCDH(1), WARS(1)	273083	12	10	12	11	3	6	2	0	1	0.85	1.00
407	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	55	ASH1L(5), ASH2L(1), DOT1L(2), EZH1(2), JMJD6(1), MEN1(1), MLL(2), MLL4(3), OGT(2), SETD2(4), WHSC1L1(3)	529835	26	21	26	8	3	14	2	4	3	0.85	1.00
408	DNA_REPLICATION_ REACTOME		42	MCM10(1), ORC3L(1), POLD1(1), RPA1(1)	122100	4	4	4	8	1	2	1	0	0	0.85	1.00
409	HSA04115_P53_SIGNALING_ PATHWAY	Genes involved in p53 signaling pathway	64	BAI1(5), CDK4(1), DDB2(1), RRM2B(2), TSC2(2)	161470	11	9	11	2	2	6	1	1	1	0.85	1.00
410	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	22	APC(7), CTBP1(1), DVL1(1)	155932	9	9	9	0	1	5	1	1	1	0.85	1.00
411	BETA_ALANINE_METABOLISM		27	ALDH3A1(1), AOC2(1), DPYS(2), SMS(2)	158534	6	5	6	5	1	3	1	0	1	0.85	1.00
412	GPCRDB_OTHER		50	CELSR2(4), CELSR3(6), CXCR3(1), EMR2(3), EMR3(5), GPR143(1), GPR61(1), GPR84(1), LGR6(1)	390309	23	18	23	10	4	13	3	1	2	0.85	1.00
413	VALINE_LEUCINE_AND_ ISOLEUCINE_DEGRADATION		36	ALDH3A1(1)	92158	1	1	1	3	0	0	0	0	1	0.86	1.00
414	GLYCOSAMINOGLYCAN_ DEGRADATION		11	NAGLU(1)	96394	1	1	1	0	0	0	0	1	0	0.86	1.00
415	HSA00350_TYROSINE_ METABOLISM	Genes involved in tyrosine metabolism	56	ADH6(1), ALDH3A1(1), AOC2(1), DDC(3), TAT(3), TPO(5), WBSCR22(1)	232638	15	14	15	8	4	8	1	0	2	0.86	1.00
416	HSA00650_BUTANOATE_ METABOLISM	Genes involved in butanoate metabolism	44	AACS(2), ALDH3A1(1), HSD17B4(1)	86728	4	4	4	3	1	2	0	0	1	0.86	1.00
417	HSA04060_CYTOKINE_ CYTOKINE_RECEPTOR_ INTERACTION	Genes involved in cytokine-cytokine receptor interaction	251	BMPR1A(2), CSF1R(2), CSF2RB(4), CXCR3(1), EGFR(2), EPOR(1), FLT4(1), IFNA16(2), IL10RA(1), IL11RA(1), IL12RB2(2), IL18RAP(3), IL1B(1), IL21R(2), IL22(1), IL22RA2(1), IL4(1), IL5RA(2), INHBC(1), MET(2), PDGFRB(5), PLEKHO2(3), TNFRSF1A(2), TNFRSF1B(1), TPO(5)	748013	49	39	49	17	14	23	4	3	5	0.86	1.00
418	FOLATE_BIOSYNTHESIS		9	ALPP(2)	39474	2	2	2	0	1	1	0	0	0	0.87	1.00
419	CARBON_FIXATION		21	PGK1(2)	50499	2	2	2	0	1	1	0	0	0	0.87	1.00
420	AMINOSUGARS_METABOLISM		15	GNE(1), HK1(3)	165454	4	3	4	5	3	1	0	0	0	0.88	1.00
421	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	11	CDC25B(2), CDK4(1)	112163	3	3	3	1	1	1	1	0	0	0.88	1.00
422	HSA00120_BILE_ACID_ BIOSYNTHESIS	Genes involved in bile acid biosynthesis	38	ADH6(1), ALDH3A1(1)	97166	2	2	2	0	0	1	0	0	1	0.88	1.00
423	HSA03050_PROTEASOME	Genes involved in proteasome	22	PSMB3(1), PSMC3(1), PSMD1(1), PSMD13(1)	140394	4	4	4	3	1	1	0	1	1	0.88	1.00
424	HSA00903_LIMONENE_ AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	25	ALDH3A1(1)	94000	1	1	1	5	0	0	0	0	1	0.88	1.00
425	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	20	PSMB3(1), PSMC3(1)	115152	2	2	2	2	0	1	0	1	0	0.88	1.00
426	HSA04662_B_CELL_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in B cell receptor signaling pathway	60	BLNK(1), BTK(2), CD19(1), CD22(4), FCGR2B(2), INPP5D(4), LYN(1), NFAT5(1), PIK3R5(4), PPP3CC(1)	380572	21	18	21	7	5	11	1	1	3	0.89	1.00
427	HSA00632_BENZOATE_ DEGRADATION_VIA_ COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	24	GCDH(1)	112053	1	1	1	5	0	0	1	0	0	0.89	1.00
428	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	11	C1QA(2), C2(2), C3(1), C9(2)	237943	7	7	7	2	1	4	0	0	2	0.90	1.00
429	HSA00071_FATTY_ACID_ METABOLISM	Genes involved in fatty acid metabolism	47	ACSL3(1), ADH6(1), ALDH3A1(1), GCDH(1), HSD17B4(1)	190998	5	5	5	3	1	2	1	0	1	0.90	1.00
430	HSA04080_NEUROACTIVE_ LIGAND_RECEPTOR_ INTERACTION	Genes involved in neuroactive ligand-receptor interaction	232	AVPR2(2), CALCR(2), CHRM1(1), CRHR1(3), CRHR2(1), CTSG(2), F2RL3(1), GABRA3(3), GABRG3(5), GABRR1(1), GLP2R(2), GPR156(1), GRIK5(2), GRIN3B(1), GRM2(3), GZMA(3), HTR1D(1), NPFFR1(1), NPY1R(3), NTSR2(2), P2RX4(1), PTH2R(4), TBXA2R(1), TRPV1(1)	748836	47	35	47	18	12	28	1	3	3	0.90	1.00
431	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	12	RELA(2)	56843	2	1	2	2	1	1	0	0	0	0.90	1.00
432	SIG_REGULATION_OF_ THE_ACTIN_CYTOSKELETON_ BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	33	FLNA(4), MYLK(1), PAK1(1), RHO(1), WASL(1)	232453	8	8	8	3	2	4	0	0	2	0.90	1.00
433	HSA00010_GLYCOLYSIS_ AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	64	ACSS1(2), ADH6(1), ALDH3A1(1), DLAT(2), DLD(1), GPI(3), HK1(3), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PGM1(1)	421042	20	16	20	2	8	8	1	1	2	0.90	1.00
434	GLUCONEOGENESIS		53	ADH6(1), ALDH3A1(1), DLAT(2), DLD(1), GPI(3), HK1(3), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PGM1(1)	353919	18	14	18	1	7	8	1	0	2	0.90	1.00
435	GLYCOLYSIS		53	ADH6(1), ALDH3A1(1), DLAT(2), DLD(1), GPI(3), HK1(3), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PGM1(1)	353919	18	14	18	1	7	8	1	0	2	0.90	1.00
436	HSA00860_PORPHYRIN_ AND_CHLOROPHYLL_ METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	41	CP(1), UGT1A7(1), UGT2B15(2)	177047	4	4	4	1	1	2	1	0	0	0.91	1.00
437	PYRUVATE_METABOLISM		37	ACACA(2), ALDH3A1(1), DLAT(2), DLD(1), GRHPR(1), LDHB(1), LDHC(1), PC(1)	165830	10	9	10	2	2	6	1	0	1	0.91	1.00
438	HSA00062_FATTY_ACID_ ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	10	HSD17B4(1)	46606	1	1	1	0	1	0	0	0	0	0.91	1.00
439	SIG_INSULIN_RECEPTOR_ PATHWAY_IN_CARDIAC_ MYOCYTES	Genes related to the insulin receptor pathway	48	BRD4(2), CAP1(1), IRS4(3), MAPK1(1), MAPK3(1), RAF1(1), RPS6KA2(2), SERPINB6(2), SLC2A4(1), SORBS1(4), SOS1(3)	363711	21	17	21	5	4	14	1	2	0	0.91	1.00
440	ST_INTEGRIN_SIGNALING_ PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	75	ARHGEF6(1), DOCK1(3), EPHB2(3), GRLF1(2), ITGA1(1), ITGA2(5), ITGA5(1), ITGA7(2), MAP3K11(1), MAPK1(1), MAPK8IP3(3), MYLK(1), PAK1(1), PTK2(2), RAF1(1), RHO(1), SOS1(3), TLN1(3), TLN2(2)	598108	37	28	37	19	11	21	2	1	2	0.91	1.00
441	PROTEASOME		17	PSMB3(1), PSMB8(1)	131622	2	2	2	1	0	1	0	1	0	0.91	1.00
442	HSA00340_HISTIDINE_ METABOLISM	Genes involved in histidine metabolism	41	ALDH3A1(1), AOC2(1), DDC(3), WBSCR22(1)	158435	6	6	6	4	2	2	1	0	1	0.91	1.00
443	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	13	CREM(1), MAPK3(1), POLR2A(2)	131919	4	4	4	1	1	2	0	1	0	0.91	1.00
444	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	13	IL10RA(1), STAT1(1)	49742	2	2	2	3	0	2	0	0	0	0.91	1.00
445	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	14	C1QA(2), C2(2), C3(1), C9(2), MASP2(1)	245974	8	8	8	2	2	4	0	0	2	0.91	1.00
446	HSA05130_PATHOGENIC_ ESCHERICHIA_COLI_ INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	51	CDH1(1), OCLN(1), PRKCA(3), TUBB2C(1), TUBB4(3), WASL(1)	180717	10	10	10	2	1	6	1	1	1	0.91	1.00
447	HSA05131_PATHOGENIC_ ESCHERICHIA_COLI_ INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	51	CDH1(1), OCLN(1), PRKCA(3), TUBB2C(1), TUBB4(3), WASL(1)	180717	10	10	10	2	1	6	1	1	1	0.91	1.00
448	COMPLEMENT_ACTIVATION_ CLASSICAL		13	C1QA(2), C2(2), C3(1), C9(2)	247798	7	7	7	4	1	4	0	0	2	0.92	1.00
449	HSA00640_PROPANOATE_ METABOLISM	Genes involved in propanoate metabolism	32	ACACA(2), ACSS1(2), ALDH3A1(1), LDHB(1), LDHC(1)	156323	7	7	7	5	1	4	0	1	1	0.92	1.00
450	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	14	NCOR2(3), POLR2A(2)	131063	5	5	5	2	2	2	0	1	0	0.92	1.00
451	G1_TO_S_CELL_CYCLE_ REACTOME		64	CDK4(1), CREB3(1), ORC3L(1), RBL1(4), RPA1(1), TNXB(12)	455795	20	14	20	9	4	11	3	0	2	0.92	1.00
452	GLYCEROLIPID_METABOLISM		44	ADH6(1), AGPAT4(1), ALDH3A1(1), LIPF(1), PNLIPRP1(3), PNLIPRP2(1)	252785	8	8	8	4	2	3	0	1	2	0.93	1.00
453	N_GLYCAN_BIOSYNTHESIS		21	B4GALT3(1), B4GALT5(1), MAN1A1(3)	138389	5	5	5	2	3	2	0	0	0	0.93	1.00
454	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	24	CDK4(1)	51410	1	1	1	0	1	0	0	0	0	0.93	1.00
455	HSA04310_WNT_SIGNALING_ PATHWAY	Genes involved in Wnt signaling pathway	144	APC(7), CAMK2A(2), CAMK2D(1), CHD8(6), CTBP1(1), CTBP2(1), DAAM1(2), DVL1(1), DVL3(1), EP300(4), FZD2(2), LRP5(3), LRP6(1), NFAT5(1), PLCB4(3), PPP2R2A(1), PPP3CC(1), PRKCA(3), SENP2(1), WNT7A(2), WNT8A(1), WNT9A(1)	804649	46	36	46	14	9	24	3	4	6	0.94	1.00
456	HSA04810_REGULATION_ OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	197	ACTN3(2), APC(7), ARAF(1), ARHGEF4(1), ARHGEF6(1), CHRM1(1), CYFIP2(3), DOCK1(3), EGFR(2), FGD1(2), GRLF1(2), ITGA1(1), ITGA2(5), ITGA5(1), ITGA7(2), ITGAL(2), ITGAM(2), ITGB4(2), ITGB6(1), MAPK1(1), MAPK3(1), MYH10(2), MYH14(4), MYLK(1), NCKAP1L(4), PAK1(1), PDGFRB(5), PIK3R5(4), PIP5K1C(1), PPP1R12B(1), PTK2(2), RAF1(1), SOS1(3), TIAM2(1), TMSL3(1), VCL(2), WASL(1)	1266639	77	52	77	31	21	40	5	5	6	0.94	1.00
457	HSA00590_ARACHIDONIC_ ACID_METABOLISM	Genes involved in arachidonic acid metabolism	50	ALOX12B(1), CYP2B6(1), PLA2G4A(4)	141391	6	5	6	4	1	4	0	1	0	0.94	1.00
458	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	182	ACTN3(2), CHAD(1), COL11A2(6), COL4A4(6), COL4A6(2), COL5A3(7), DOCK1(3), EGFR(2), FARP2(1), FLNA(4), FLNB(3), GRLF1(2), ITGA1(1), ITGA2(5), ITGA5(1), ITGA7(2), ITGB4(2), ITGB6(1), LAMA1(7), LAMB1(5), LAMB2(3), LAMB4(3), MAPK1(1), MAPK3(1), MET(2), MYLK(1), PAK1(1), PDGFRB(5), PIK3R5(4), PIP5K1C(1), PRKCA(3), PTK2(2), RAF1(1), RAPGEF1(2), SOS1(3), TLN1(3), TLN2(2), TNC(5), TNXB(12), VCL(2)	1830850	120	70	120	42	28	66	5	8	13	0.95	1.00
459	PROPANOATE_METABOLISM		31	ACACA(2), ALDH3A1(1), LDHB(1), LDHC(1)	128937	5	5	5	5	0	4	0	0	1	0.95	1.00
460	HSA00532_CHONDROITIN_ SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	17	CHPF(1), XYLT2(1)	110692	2	2	2	1	1	0	0	1	0	0.95	1.00
461	AMINOACYL_TRNA_BIOSYNTHESIS		20	LARS(1), LARS2(2), MARS(1), WARS(1)	170395	5	5	5	3	1	3	0	1	0	0.96	1.00
462	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	30	INSR(2), MAP2K6(2), PPP3CC(1)	282413	5	5	5	4	0	2	0	1	2	0.96	1.00
463	HSA04910_INSULIN_ SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	128	ACACA(2), ARAF(1), GYS1(1), GYS2(2), INPP5D(4), INSR(2), IRS4(3), MAPK1(1), MAPK3(1), MKNK2(1), PFKP(2), PHKG1(1), PHKG2(1), PIK3R5(4), PRKAG2(2), PRKCZ(1), PTPRF(4), RAF1(1), RAPGEF1(2), SLC2A4(1), SORBS1(4), SOS1(3), TRIP10(1), TSC2(2)	821089	47	37	47	21	9	30	0	4	4	0.97	1.00
464	MRNA_PROCESSING_ REACTOME		90	CLK2(1), CLK3(1), DDX20(1), DHX8(1), NXF1(1), POLR2A(2), PRPF3(3), PRPF8(1), SF3A2(1), SFRS4(1), SRRM1(1), SUPT5H(1)	518764	15	14	15	7	3	7	1	3	1	0.97	1.00
465	ACETYLCHOLINE_SYNTHESIS		8		0	0	0	0	0	0	0	0	0	0	1.00	1.00
466	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
467	BLOOD_GROUP_GLYCOLIPID_ BIOSYNTHESIS_NEOLACTOSERIES		7		0	0	0	0	0	0	0	0	0	0	1.00	1.00
468	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	15		0	0	0	0	0	0	0	0	0	0	1.00	1.00
469	CYANOAMINO_ACID_ METABOLISM		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
470	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	8		0	0	0	0	0	0	0	0	0	0	1.00	1.00
471	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	15		0	0	0	0	0	0	0	0	0	0	1.00	1.00
472	HSA00031_INOSITOL_ METABOLISM	Genes involved in inositol metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
473	HSA00072_SYNTHESIS_ AND_DEGRADATION_ OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	9		0	0	0	0	0	0	0	0	0	0	1.00	1.00
474	HSA00300_LYSINE_ BIOSYNTHESIS	Genes involved in lysine biosynthesis	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
475	HSA00471_D_GLUTAMINE_ AND_D_GLUTAMATE_ METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
476	HSA00472_D_ARGININE_ AND_D_ORNITHINE_ METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	1		0	0	0	0	0	0	0	0	0	0	1.00	1.00
477	HSA00550_PEPTIDOGLYCAN_ BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
478	HSA00627_1,4_DICHLOROBENZENE_ DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	1		0	0	0	0	0	0	0	0	0	0	1.00	1.00
479	HSA00643_STYRENE_ DEGRADATION	Genes involved in styrene degradation	3		0	0	0	0	0	0	0	0	0	0	1.00	1.00
480	HSA00660_C5_BRANCHED_ DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
481	HSA00780_BIOTIN_ METABOLISM	Genes involved in biotin metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
482	HSA00785_LIPOIC_ ACID_METABOLISM	Genes involved in lipoic acid metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
483	HSA00830_RETINOL_ METABOLISM	Genes involved in retinol metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
484	HSA00902_MONOTERPENOID_ BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	1		0	0	0	0	0	0	0	0	0	0	1.00	1.00
485	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
486	INOSITOL_METABOLISM		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
487	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	13		0	0	0	0	0	0	0	0	0	0	1.00	1.00
488	LYSINE_BIOSYNTHESIS		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
489	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
490	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	10		0	0	0	0	0	0	0	0	0	0	1.00	1.00
491	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
492	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	3		0	0	0	0	0	0	0	0	0	0	1.00	1.00
493	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
494	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
495	ST_PAC1_RECEPTOR_ PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
496	SYNTHESIS_AND_DEGRADATION_ OF_KETONE_BODIES		4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
497	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	7		0	0	0	0	0	0	0	0	0	0	1.00	1.00
498	HSA04020_CALCIUM_ SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	159	ADCY4(3), ADCY8(8), ATP2A3(2), ATP2B1(4), ATP2B2(4), ATP2B4(1), CACNA1A(6), CACNA1D(1), CACNA1F(3), CACNA1G(4), CACNA1H(1), CAMK2A(2), CAMK2D(1), CAMK4(1), CHRM1(1), EGFR(2), ERBB3(2), GNAL(1), GNAS(2), ITPR1(1), ITPR2(5), ITPR3(3), MYLK(1), NOS3(1), P2RX4(1), PDE1A(2), PDGFRB(5), PHKG1(1), PHKG2(1), PLCB4(3), PLCE1(6), PPP3CC(1), PRKCA(3), SLC8A3(5), TBXA2R(1)	1361312	89	53	89	29	20	49	5	7	8	1.00	1.00
499	HSA00500_STARCH_ AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	81	AGL(2), DDX19A(2), DDX4(2), DDX54(2), ENPP3(3), ERCC2(1), GPI(3), GYS1(1), GYS2(2), HK1(3), MGAM(7), PGM1(1), SKIV2L2(3), UGT1A7(1), UGT2B15(2)	590740	35	27	35	16	10	17	2	2	4	1.00	1.00
500	HSA00620_PYRUVATE_ METABOLISM	Genes involved in pyruvate metabolism	41	ACACA(2), ACSS1(2), ALDH3A1(1), DLAT(2), DLD(1), GRHPR(1), LDHB(1), LDHC(1), PC(1)	220351	12	11	12	3	3	6	1	1	1	1.00	1.00
501	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	129	CHAD(1), COL11A2(6), COL17A1(2), COL4A4(6), COL4A6(2), COL5A3(7), GJA10(3), GJB1(1), ITGB4(2), KRT13(1), KRT3(2), KRT6B(3), KRT72(1), KRT74(1), KRT75(1), KRT76(1), KRT79(1), KRT9(1), LAMA1(7), LAMB1(5), LAMB2(3), LAMB4(3), NES(1), TNC(5), TNXB(12)	1483410	78	55	78	26	19	46	1	3	9	1.00	1.00
502	HSA04920_ADIPOCYTOKINE_ SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	69	ACSL3(1), ADIPOR1(2), CAMKK1(2), CD36(1), IRS4(3), JAK2(3), PRKAG2(2), RELA(2), SLC2A4(1), TNFRSF1A(2), TNFRSF1B(1)	385306	20	16	20	4	5	9	2	2	2	1.00	1.00
503	HSA00510_N_GLYCAN_ BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	41	B4GALT3(1), GANAB(4), MAN1A1(3), MAN2A1(4)	238470	12	11	12	2	4	7	0	0	1	1.00	1.00
504	PHOSPHATIDYLINOSITOL_ SIGNALING_SYSTEM		81	ACVRL1(2), BMPR1A(2), CLK2(1), COL4A3BP(3), PIK3C2A(1), PIK3C2B(5), PIK3C2G(1), PLCB4(3), PRKCA(3), PRKCE(2), PRKCZ(1), RAF1(1), RPS6KA2(2), RPS6KA4(2)	590579	29	28	29	8	6	15	2	3	3	1.00	1.00
505	CALCINEURIN_NF_AT_ SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	90	CAMK4(1), CD3E(1), EP300(4), FCGR3A(2), GRLF1(2), IL1B(1), IL4(1), NFAT5(1), PAK1(1), PPP3CC(1), PTPRC(4), RELA(2), XPO5(1)	465519	22	18	22	14	6	12	1	0	3	1.00	1.00
506	HSA00230_PURINE_ METABOLISM	Genes involved in purine metabolism	138	ADA(1), ADCY4(3), ADCY5(2), ADCY8(8), AK7(1), ENPP3(3), GUCY2C(3), GUCY2D(1), NT5C2(1), NT5C3(2), NT5E(1), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4C(1), PFAS(5), POLD1(1), POLR2A(2), POLR2F(1), RRM1(1), RRM2B(2)	920999	43	33	42	18	10	22	4	5	2	1.00	1.00
507	SIG_PIP3_SIGNALING_ IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	62	CREB3(1), IFI27(1), IRS4(3), MET(2), PAK1(1), PTK2(2), RPS6KA2(2), SLC2A4(1), SOS1(3), TSC2(2)	393737	18	17	18	4	4	10	1	2	1	1.00	1.00
508	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	35	ACTN3(2), CAPN1(2), ITGA1(1), MAPK1(1), MAPK3(1), PPP1R12B(1), PTK2(2), RAF1(1), SOS1(3), TLN1(3), VCL(2)	417636	19	19	19	4	6	9	1	2	1	1.00	1.00
509	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	9	ITGAL(2), SELL(1)	66420	3	3	3	3	1	2	0	0	0	1.00	1.00
510	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	32	CASP10(2), CFLAR(1), DFFB(1), MAP3K14(1), RELA(2), SPTAN1(2)	201584	9	8	9	5	2	6	0	0	1	1.00	1.00
511	PURINE_METABOLISM		106	ADA(1), ADCY4(3), ADCY5(2), ADCY8(8), ENPP3(3), GUCY2C(3), GUCY2D(1), NT5E(1), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4C(1), PDE6B(1), PFAS(5), POLD1(1), POLR2A(2), POLR2F(1), RRM1(1)	882857	38	30	37	17	10	18	3	5	2	1.00	1.00
512	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	24	CAPN1(2), CXCR3(1), EGFR(2), ITGA1(1), MAPK1(1), MAPK3(1), MYLK(1), PTK2(2), TLN1(3)	328549	14	14	14	5	5	7	1	0	1	1.00	1.00
513	GAMMA_HEXACHLOROCYCLOHEXANE_ DEGRADATION		29	ACPP(1), ALPP(2), CYP19A1(3), CYP2B6(1), CYP2F1(1)	192798	8	8	8	6	3	5	0	0	0	1.00	1.00
514	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	12	ARFGAP1(1), COPA(4), GBF1(4)	218539	9	9	9	0	0	6	1	1	1	1.00	1.00
515	GPCRDB_CLASS_A_RHODOPSIN_ LIKE		164	AVPR2(2), CHRM1(1), CXCR3(1), F2RL3(1), GALT(1), HTR1D(1), NPY1R(3), NTSR2(2), RGR(1), RHO(1), TBXA2R(1)	369060	15	13	15	4	4	10	0	0	1	1.00	1.00
516	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	6	IL1B(1), MST1(4), MST1R(2)	175724	7	7	7	1	1	4	1	1	0	1.00	1.00
517	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	16	ACTN3(2), CAPN1(2), ITGA1(1), PTK2(2), SPTAN1(2), TLN1(3)	313961	12	12	12	4	5	4	1	1	1	1.00	1.00
518	HSA00970_AMINOACYL_ TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	37	AARS2(4), LARS(1), LARS2(2), MARS(1), NARS2(3), SARS2(1), VARS(3), WARS(1)	438185	16	10	16	6	2	8	2	2	2	1.00	1.00
519	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	27	CHRM1(1), CHRNA1(2), FLT4(1), NOS3(1), SLC7A1(2)	192947	7	7	7	6	1	5	0	1	0	1.00	1.00
520	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	7	MAX(1)	27599	1	1	1	0	0	1	0	0	0	1.00	1.00
521	HSA00020_CITRATE_ CYCLE	Genes involved in citrate cycle (TCA cycle)	27	ACLY(1), ACO1(1), DLD(1), DLST(1), IDH3A(1), IDH3B(1), PC(1)	195091	7	7	7	2	3	3	0	1	0	1.00	1.00
522	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	19	PRKCA(3), PTK2(2), STAT1(1), TLN1(3)	251431	9	8	9	2	2	4	1	1	1	1.00	1.00
523	HSA00790_FOLATE_ BIOSYNTHESIS	Genes involved in folate biosynthesis	39	ALPP(2), DDX19A(2), DDX4(2), DDX54(2), ERCC2(1), SKIV2L2(3)	335445	12	11	12	6	2	8	1	0	1	1.00	1.00
524	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	22	ITGA1(1), MAPK1(1), MAPK3(1), MYLK(1), PTK2(2), RAF1(1), TLN1(3)	281433	10	10	10	5	3	5	1	0	1	1.00	1.00
525	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	30	ARHGEF11(7), ARHGEF5(1), MYLK(1), PPP1R12B(1), TLN1(3), VCL(2)	423935	15	14	15	4	5	6	2	1	1	1.00	1.00
526	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_ DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	23	ACP6(1), ACPP(1), ALPP(2)	113356	4	4	4	2	2	2	0	0	0	1.00	1.00
527	HSA00602_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_NEO_ LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	21	B4GALT3(1), FUT6(2)	85807	3	3	3	0	1	2	0	0	0	1.00	1.00
528	HSA03320_PPAR_SIGNALING_ PATHWAY	Genes involved in PPAR signaling pathway	67	ACSL3(1), CD36(1), PLTP(1), SLC27A4(2), SORBS1(4)	261215	9	8	9	10	3	5	1	0	0	1.00	1.00
529	ALANINE_AND_ASPARTATE_ METABOLISM		21	AGXT2(3), CAD(2), CRAT(1), PC(1)	205479	7	7	7	2	1	5	1	0	0	1.00	1.00
530	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	19	KLRC3(1), MAPK3(1), PAK1(1)	90143	3	3	3	1	1	2	0	0	0	1.00	1.00
531	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	21	INSR(2), MAPK3(1), RAF1(1), RASA1(2), SLC2A4(1), SOS1(3)	306528	10	10	10	1	1	6	0	1	2	1.00	1.00
532	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	50	CAMK4(1), ELSPBP1(1), MAPK1(1), MAPK3(1), PPP3CC(1), RAF1(1)	189558	6	6	6	3	1	4	0	0	1	1.00	1.00
533	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	21	CASP10(2), DFFB(1)	95842	3	3	3	1	0	3	0	0	0	1.00	1.00
534	HSA00290_VALINE_ LEUCINE_AND_ISOLEUCINE_ BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	12	BCAT2(2), LARS(1), LARS2(2), VARS(3)	255722	8	6	8	1	1	5	1	0	1	1.00	1.00
535	HSA00240_PYRIMIDINE_ METABOLISM	Genes involved in pyrimidine metabolism	86	CAD(2), DPYS(2), NT5C2(1), NT5C3(2), NT5E(1), POLD1(1), POLR2A(2), POLR2F(1), RRM1(1), RRM2B(2)	493873	15	15	15	6	3	9	2	1	0	1.00	1.00
536	GLOBOSIDE_METABOLISM		13	ST3GAL4(1)	33837	1	1	1	1	0	1	0	0	0	1.00	1.00
537	KERATAN_SULFATE_ BIOSYNTHESIS		10	B4GALT3(1), B4GALT5(1), ST3GAL4(1)	102123	3	3	3	4	1	2	0	0	0	1.00	1.00
538	BLOOD_GROUP_GLYCOLIPID_ BIOSYNTHESIS_LACTOSERIES		7	FUT6(2)	69204	2	2	2	1	0	2	0	0	0	1.00	1.00
539	HSA00710_CARBON_ FIXATION	Genes involved in carbon fixation	23	PGK1(2)	70052	2	2	2	1	1	1	0	0	0	1.00	1.00
540	TRANSLATION_FACTORS		37	EEF1A2(1), EIF2B1(1), EIF2B3(1), EIF2B4(1), EIF4A1(1), EIF4G3(2), EIF5(1)	289002	8	8	8	3	0	5	1	0	2	1.00	1.00
541	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	9	EIF5(1)	37122	1	1	1	1	0	1	0	0	0	1.00	1.00
542	HSA00601_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	10	ST3GAL4(1)	37265	1	1	1	2	0	1	0	0	0	1.00	1.00
543	HSA00980_METABOLISM_ OF_XENOBIOTICS_BY_ CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	69	ADH6(1), AKR1C1(1), ALDH3A1(1), CYP2B6(1), CYP2F1(1), UGT1A7(1), UGT2B15(2)	302253	8	7	8	6	1	5	1	0	1	1.00	1.00
544	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	38	DLD(1), MAP2K5(1), MAP3K1(4), MAP3K11(1), MAP3K12(1)	309823	8	6	8	3	3	3	0	0	2	1.00	1.00
545	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	8	ACLY(1), PC(1)	83967	2	2	2	0	0	2	0	0	0	1.00	1.00
546	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	5	CHRM1(1), CHRNA1(2)	127293	3	3	3	1	0	3	0	0	0	1.00	1.00
547	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	10	LDHB(1), LDHC(1)	87868	2	2	2	1	0	2	0	0	0	1.00	1.00
548	PYRIMIDINE_METABOLISM		54	CAD(2), DPYS(2), NT5E(1), POLD1(1), POLR2A(2), POLR2F(1), RRM1(1)	442949	10	10	10	5	3	6	0	1	0	1.00	1.00
549	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	8	STAT1(1)	44466	1	1	1	1	0	1	0	0	0	1.00	1.00
550	HSA00533_KERATAN_ SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	16	B4GALT3(1), ST3GAL4(1)	90065	2	2	2	4	1	1	0	0	0	1.00	1.00
551	GLUTAMATE_METABOLISM		23	CAD(2)	90548	2	2	2	1	0	2	0	0	0	1.00	1.00
552	MITOCHONDRIAL_FATTY_ ACID_BETAOXIDATION		15	ACSL3(1)	45694	1	1	1	2	0	1	0	0	0	1.00	1.00
553	NUCLEOTIDE_METABOLISM		14	POLD1(1), RRM1(1)	92218	2	2	2	1	1	1	0	0	0	1.00	1.00
554	GPCRDB_CLASS_A_RHODOPSIN_ LIKE2		13	GPR109B(2)	102990	2	2	2	0	0	2	0	0	0	1.00	1.00
555	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	23	CAMK2A(2), CAMK2D(1), CAMK4(1), PPP3CC(1), SLC2A4(1)	317527	6	5	6	3	3	2	0	0	1	1.00	1.00
556	1_AND_2_METHYLNAPHTHALENE_ DEGRADATION		7	ADH6(1)	52969	1	1	1	0	0	1	0	0	0	1.00	1.00
557	UBIQUITIN_MEDIATED_ PROTEOLYSIS		23	NRF1(1)	54355	1	1	1	0	0	1	0	0	0	1.00	1.00
558	HSA00531_GLYCOSAMINOGLYCAN_ DEGRADATION	Genes involved in glycosaminoglycan degradation	17	HGSNAT(1), HYAL1(3), NAGLU(1)	273701	5	5	5	1	0	3	0	1	1	1.00	1.00
559	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	12	WASL(1)	56120	1	1	1	0	0	1	0	0	0	1.00	1.00
560	MONOAMINE_GPCRS		32	CHRM1(1), HTR1D(1)	118295	2	2	2	0	1	1	0	0	0	1.00	1.00
561	HSA01032_GLYCAN_ STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	29	HGSNAT(1), HYAL1(3), NAGLU(1), NEU1(2)	429709	7	7	7	2	1	4	0	1	1	1.00	1.00
562	N_GLYCAN_DEGRADATION		13	NEU1(2)	130361	2	2	2	0	1	1	0	0	0	1.00	1.00
563	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	9	RAB5A(1)	66336	1	1	1	2	0	1	0	0	0	1.00	1.00
564	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	10	SNCAIP(2)	135265	2	2	2	0	0	2	0	0	0	1.00	1.00
565	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	23	POLR2A(2), POLR2F(1)	227569	3	3	3	1	1	1	0	1	0	1.00	1.00
566	RNA_POLYMERASE		14	POLR2A(2), POLR2F(1)	233558	3	3	3	1	1	1	0	1	0	1.00	1.00
567	RNA_TRANSCRIPTION_ REACTOME		37	GTF2H1(1), POLR2A(2), POLR2F(1)	318821	4	4	4	2	1	1	0	1	1	1.00	1.00
568	HSA00330_ARGININE_ AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	33	NOS3(1)	82246	1	1	1	1	0	1	0	0	0	1.00	1.00
569	HSA00511_N_GLYCAN_ DEGRADATION	Genes involved in N-glycan degradation	15	NEU1(2)	179445	2	2	2	1	1	1	0	0	0	1.00	1.00
570	HSA00624_1_AND_2_ METHYLNAPHTHALENE_ DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	22	ADH6(1)	100005	1	1	1	3	0	1	0	0	0	1.00	1.00
571	HSA00930_CAPROLACTAM_ DEGRADATION	Genes involved in caprolactam degradation	13	HSD17B4(1)	113260	1	1	1	2	1	0	0	0	0	1.00	1.00
572	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	6	CHRM1(1)	114177	1	1	1	0	0	1	0	0	0	1.00	1.00
573	RIBOSOMAL_PROTEINS		94	RPS6KA2(2)	235933	2	2	2	1	0	1	0	1	0	1.00	1.00
574	HSA03010_RIBOSOME	Genes involved in ribosome	67	RPL22L1(1)	159500	1	1	1	1	1	0	0	0	0	1.00	1.00
575	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	5		13689	0	0	0	2	0	0	0	0	0	1.00	1.00
576	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	12		56114	0	0	0	0	0	0	0	0	0	1.00	1.00
577	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	16		8028	0	0	0	0	0	0	0	0	0	1.00	1.00
578	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	6		43096	0	0	0	0	0	0	0	0	0	1.00	1.00
579	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	6		13788	0	0	0	0	0	0	0	0	0	1.00	1.00
580	BIOSYNTHESIS_OF_ STEROIDS		14		20532	0	0	0	0	0	0	0	0	0	1.00	1.00
581	CAPROLACTAM_DEGRADATION		5		82610	0	0	0	2	0	0	0	0	0	1.00	1.00
582	CHOLESTEROL_BIOSYNTHESIS		15		19326	0	0	0	0	0	0	0	0	0	1.00	1.00
583	EICOSANOID_SYNTHESIS		17		15055	0	0	0	0	0	0	0	0	0	1.00	1.00
584	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	9		55160	0	0	0	0	0	0	0	0	0	1.00	1.00
585	FATTY_ACID_BIOSYNTHESIS_ PATH_2		9		46261	0	0	0	2	0	0	0	0	0	1.00	1.00
586	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	8		5779	0	0	0	0	0	0	0	0	0	1.00	1.00
587	FOSBPATHWAY	FOSB gene expression and drug abuse	5		29113	0	0	0	1	0	0	0	0	0	1.00	1.00
588	GLUTATHIONE_METABOLISM		31		97134	0	0	0	1	0	0	0	0	0	1.00	1.00
589	HEME_BIOSYNTHESIS		9		44493	0	0	0	0	0	0	0	0	0	1.00	1.00
590	HSA00100_BIOSYNTHESIS_ OF_STEROIDS	Genes involved in biosynthesis of steroids	24		30927	0	0	0	0	0	0	0	0	0	1.00	1.00
591	HSA00130_UBIQUINONE_ BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	8		20831	0	0	0	0	0	0	0	0	0	1.00	1.00
592	HSA00232_CAFFEINE_ METABOLISM	Genes involved in caffeine metabolism	7		29996	0	0	0	1	0	0	0	0	0	1.00	1.00
593	HSA00363_BISPHENOL_ A_DEGRADATION	Genes involved in bisphenol A degradation	14		42350	0	0	0	0	0	0	0	0	0	1.00	1.00
594	HSA00460_CYANOAMINO_ ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	6		14908	0	0	0	0	0	0	0	0	0	1.00	1.00
595	HSA00603_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	14		23437	0	0	0	0	0	0	0	0	0	1.00	1.00
596	HSA00604_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	16		23437	0	0	0	0	0	0	0	0	0	1.00	1.00
597	HSA00625_TETRACHLOROETHENE_ DEGRADATION	Genes involved in tetrachloroethene degradation	7		21122	0	0	0	0	0	0	0	0	0	1.00	1.00
598	HSA00642_ETHYLBENZENE_ DEGRADATION	Genes involved in ethylbenzene degradation	12		47036	0	0	0	3	0	0	0	0	0	1.00	1.00
599	HSA00791_ATRAZINE_ DEGRADATION	Genes involved in atrazine degradation	9		80286	0	0	0	0	0	0	0	0	0	1.00	1.00
600	HSA00900_TERPENOID_ BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	6		24700	0	0	0	0	0	0	0	0	0	1.00	1.00
601	HSA03060_PROTEIN_ EXPORT	Genes involved in protein export	8		17112	0	0	0	1	0	0	0	0	0	1.00	1.00
602	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	15		10974	0	0	0	0	0	0	0	0	0	1.00	1.00
603	HYPERTROPHY_MODEL		17		19055	0	0	0	1	0	0	0	0	0	1.00	1.00
604	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	19		26394	0	0	0	1	0	0	0	0	0	1.00	1.00
605	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	8		57749	0	0	0	2	0	0	0	0	0	1.00	1.00
606	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	9		75154	0	0	0	0	0	0	0	0	0	1.00	1.00
607	NUCLEOTIDE_GPCRS		8		63941	0	0	0	0	0	0	0	0	0	1.00	1.00
608	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	12		26299	0	0	0	0	0	0	0	0	0	1.00	1.00
609	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	6		16985	0	0	0	0	0	0	0	0	0	1.00	1.00
610	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	9		4986	0	0	0	0	0	0	0	0	0	1.00	1.00
611	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	6		19471	0	0	0	0	0	0	0	0	0	1.00	1.00
612	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	9		26299	0	0	0	0	0	0	0	0	0	1.00	1.00
613	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	6		30305	0	0	0	0	0	0	0	0	0	1.00	1.00
614	TERPENOID_BIOSYNTHESIS		4		14440	0	0	0	0	0	0	0	0	0	1.00	1.00
615	UBIQUINONE_BIOSYNTHESIS		15		62388	0	0	0	1	0	0	0	0	0	1.00	1.00
616	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	5		5566	0	0	0	0	0	0	0	0	0	1.00	1.00

Notes: (Please see notes under significantly mutated gene table)