rank	geneset	description	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	p	q
1	GPCRDB_CLASS_B_SECRETIN_ LIKE		20	CALCR(2), CRHR1(3), CRHR2(1), ELTD1(9), EMR1(5), EMR2(3), GLP2R(2), GPR64(3)	70035	28	22	28	7	6	13	1	4	4	<1.00e-11	<7.70e-10
2	STRIATED_MUSCLE_ CONTRACTION		37	ACTN3(2), DMD(10), MYBPC3(1), MYH6(8), MYH7(6), MYH8(14), MYOM1(2), NEB(9), TNNT3(1), TTN(173)	823331	226	91	225	69	52	114	20	19	21	<1.00e-11	<7.70e-10
3	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	28	CHRM1(1), CHRNA1(2), FLT4(1), NOS3(1), RYR2(60), SLC7A1(2)	268724	67	41	66	20	12	38	7	3	7	<1.00e-11	<7.70e-10
4	HSA04720_LONG_TERM_ POTENTIATION	Genes involved in long-term potentiation	67	ADCY8(8), ARAF(1), BRAF(4), CACNA1C(14), CAMK2A(2), CAMK2D(1), CAMK4(1), CREBBP(10), EP300(4), GRIA1(5), GRIN2B(11), GRM1(8), ITPR1(1), ITPR2(5), ITPR3(3), KRAS(2), MAPK1(1), MAPK3(1), PLCB1(6), PLCB4(3), PPP3CC(1), PRKCA(3), RAF1(1), RPS6KA2(2)	461187	98	57	98	27	29	39	4	10	16	<1.00e-11	<7.70e-10
5	HSA04730_LONG_TERM_ DEPRESSION	Genes involved in long-term depression	74	ARAF(1), BRAF(4), CACNA1A(6), CRHR1(3), GNAS(2), GRIA1(5), GRM1(8), GUCY2C(3), GUCY2D(1), ITPR1(1), ITPR2(5), ITPR3(3), KRAS(2), LYN(1), MAPK1(1), MAPK3(1), NOS3(1), PLA2G4A(4), PLCB1(6), PLCB4(3), PPP2R2A(1), PRKCA(3), RAF1(1), RYR1(23)	551618	89	53	89	25	15	50	3	10	11	<1.00e-11	<7.70e-10
6	HSA04020_CALCIUM_ SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	169	ADCY2(11), ADCY3(3), ADCY4(3), ADCY8(8), ATP2A3(2), ATP2B1(4), ATP2B2(4), ATP2B4(1), CACNA1A(6), CACNA1C(14), CACNA1D(1), CACNA1E(14), CACNA1F(3), CACNA1G(4), CACNA1H(1), CACNA1I(7), CAMK2A(2), CAMK2D(1), CAMK4(1), CHRM1(1), EGFR(2), ERBB3(2), GNAL(1), GNAS(2), GRM1(8), ITPR1(1), ITPR2(5), ITPR3(3), MYLK(1), NOS3(1), P2RX4(1), PDE1A(2), PDGFRB(5), PHKG1(1), PHKG2(1), PLCB1(6), PLCB4(3), PLCE1(6), PPP3CC(1), PRKCA(3), RYR1(23), RYR2(60), RYR3(24), SLC8A3(5), TBXA2R(1)	1662500	259	92	258	73	60	141	15	18	25	<1.00e-11	<7.70e-10
7	SMOOTH_MUSCLE_CONTRACTION		138	ADCY2(11), ADCY3(3), ADCY4(3), ADCY5(2), ADCY8(8), ATP2A3(2), CAMK2A(2), CAMK2D(1), CREB3(1), CRHR1(3), GRK4(1), IL1B(1), ITPR1(1), ITPR2(5), ITPR3(3), NOS3(1), PRKCA(3), PRKCE(2), PRKCZ(1), RGS6(3), RYR1(23), RYR2(60), RYR3(24), TNXB(12), USP5(1)	1159895	177	77	176	52	51	89	11	11	15	<1.00e-11	<7.70e-10
8	CALCIUM_REGULATION_ IN_CARDIAC_CELLS		139	ADCY2(11), ADCY3(3), ADCY4(3), ADCY5(2), ADCY8(8), ATP1B2(1), ATP2A3(2), ATP2B1(4), ATP2B2(4), CACNA1A(6), CACNA1C(14), CACNA1D(1), CACNA1E(14), CAMK2A(2), CAMK2D(1), CAMK4(1), CHRM1(1), GJB1(1), GRK4(1), ITPR1(1), ITPR2(5), ITPR3(3), PEA15(1), PRKCA(3), PRKCE(2), PRKCZ(1), RGS6(3), RYR1(23), RYR2(60), RYR3(24), SLC8A3(5), USP5(1)	1466343	212	88	211	58	59	109	11	13	20	<1.00e-11	<7.70e-10
9	HSA04512_ECM_RECEPTOR_ INTERACTION	Genes involved in ECM-receptor interaction	87	AGRN(1), CD36(1), CHAD(1), COL11A2(6), COL1A1(4), COL4A1(6), COL4A4(6), COL4A6(2), COL5A3(7), FNDC3A(1), GP1BA(3), GP5(3), HSPG2(4), ITGA1(1), ITGA2(5), ITGA5(1), ITGA7(2), ITGA8(8), ITGB4(2), ITGB6(1), LAMA1(7), LAMA2(10), LAMA3(6), LAMA5(5), LAMB1(5), LAMB2(3), LAMB4(3), RELN(27), TNC(5), TNXB(12), VWF(12)	1365132	160	78	160	51	48	77	5	12	18	1.60e-10	1.10e-08
10	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	16	C3(1), C6(11), C7(4), ITGAL(2), SELP(6)	74494	24	23	24	8	5	10	3	0	6	6.75e-10	4.16e-08
11	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	7	PLCB1(6), PRKCA(3), VAV1(5)	27170	14	12	14	2	4	4	1	4	1	4.16e-09	2.14e-07
12	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	23	APC(7), EPHB2(3), ITPR1(1), ITPR2(5), ITPR3(3), KCNJ9(3), MAPK1(1), RHO(1), RYR1(23)	233311	47	37	47	10	7	28	3	5	4	4.16e-09	2.14e-07
13	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	131	ACTN3(2), ASH1L(5), CDK4(1), EPB41L1(2), EPB41L3(6), INADL(5), KRAS(2), LLGL1(1), LLGL2(2), MAGI1(3), MPDZ(2), MYH1(9), MYH10(2), MYH11(6), MYH13(11), MYH14(4), MYH2(14), MYH4(11), MYH6(8), MYH7(6), MYH7B(2), MYH8(14), OCLN(1), PARD3(3), PPP2R2A(1), PRKCA(3), PRKCE(2), PRKCZ(1), SPTAN1(2), SYMPK(2), TJAP1(4), YES1(2)	1160276	139	75	139	47	42	56	10	15	16	5.25e-09	2.49e-07
14	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	7	RELN(27)	114849	27	18	27	7	6	9	2	6	4	2.97e-08	1.31e-06
15	HSA04912_GNRH_SIGNALING_ PATHWAY	Genes involved in GnRH signaling pathway	95	ADCY2(11), ADCY3(3), ADCY4(3), ADCY5(2), ADCY8(8), CACNA1C(14), CACNA1D(1), CACNA1F(3), CAMK2A(2), CAMK2D(1), EGFR(2), GNAS(2), ITPR1(1), ITPR2(5), ITPR3(3), KRAS(2), MAP2K6(2), MAP3K1(4), MAPK1(1), MAPK3(1), PLA2G4A(4), PLCB1(6), PLCB4(3), PRKCA(3), RAF1(1), SOS1(3)	690395	91	66	91	30	31	37	4	9	10	3.95e-08	1.62e-06
16	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	6	C3(1), C6(11), C7(4), C9(2)	57896	18	17	18	5	3	7	3	0	5	7.17e-08	2.76e-06
17	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	192	ACTN3(2), BRAF(4), CHAD(1), COL11A2(6), COL1A1(4), COL4A1(6), COL4A4(6), COL4A6(2), COL5A3(7), DOCK1(3), EGFR(2), FARP2(1), FLNA(4), FLNB(3), GRLF1(2), ITGA1(1), ITGA2(5), ITGA5(1), ITGA7(2), ITGA8(8), ITGB4(2), ITGB6(1), LAMA1(7), LAMA2(10), LAMA3(6), LAMA5(5), LAMB1(5), LAMB2(3), LAMB4(3), MAPK1(1), MAPK3(1), MET(2), MYLK(1), PAK1(1), PDGFRB(5), PIK3R5(4), PIP5K1C(1), PRKCA(3), PTK2(2), RAF1(1), RAPGEF1(2), RELN(27), SOS1(3), TLN1(3), TLN2(2), TNC(5), TNXB(12), VAV1(5), VCL(2), VWF(12)	1988895	207	88	207	67	54	104	9	17	23	1.98e-07	6.88e-06
18	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	17	GRM1(8), PLCB1(6)	32130	14	13	14	4	3	6	0	1	4	2.01e-07	6.88e-06
19	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	21	GRIN2B(11), PPP3CC(1), PRKCA(3)	47365	15	12	15	4	3	4	1	4	3	2.40e-07	7.78e-06
20	GPCRDB_CLASS_C_METABOTROPIC_ GLUTAMATE_PHEROMONE		13	CASR(5), GRM1(8), GRM2(3)	43244	16	15	16	5	2	9	0	1	4	2.77e-07	8.54e-06
21	HSA04540_GAP_JUNCTION	Genes involved in gap junction	92	ADCY2(11), ADCY3(3), ADCY4(3), ADCY5(2), ADCY8(8), EGFR(2), GNAS(2), GRM1(8), GUCY2C(3), GUCY2D(1), ITPR1(1), ITPR2(5), ITPR3(3), KRAS(2), MAP2K5(1), MAPK1(1), MAPK3(1), PDGFRB(5), PLCB1(6), PLCB4(3), PRKCA(3), RAF1(1), SOS1(3), TUBB2C(1), TUBB4(3)	610012	82	56	82	23	19	39	4	9	11	3.87e-07	0.000011
22	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	7	CREBBP(10), EP300(4)	37855	14	13	14	3	3	6	0	2	3	1.58e-06	0.000044
23	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	13	KEAP1(13), MAPK1(1), PRKCA(3)	54418	17	17	17	0	3	10	1	2	1	3.02e-06	0.000081
24	HSA04664_FC_EPSILON_ RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	74	BTK(2), IL4(1), INPP5D(4), KRAS(2), LYN(1), MAP2K6(2), MAPK1(1), MAPK3(1), MS4A2(1), PIK3R5(4), PLA2G4A(4), PRKCA(3), PRKCE(2), RAF1(1), SOS1(3), VAV1(5)	217583	37	30	37	7	7	18	1	6	5	3.20e-06	0.000082
25	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	13	CREBBP(10), EP300(4)	42669	14	13	14	3	3	6	0	2	3	5.88e-06	0.00014
26	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	34	BRAF(4), EGFR(2), EPHB2(3), ITPR1(1), ITPR2(5), ITPR3(3), KCNJ9(3), MAPK1(1), PLCB1(6), PLCB4(3), RAF1(1), SOS1(3)	183871	35	27	35	9	11	17	2	2	3	6.07e-06	0.00014
27	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	99	ADCY2(11), ADCY3(3), ADCY4(3), ADCY5(2), ADCY8(8), CAMK2A(2), CAMK2D(1), CREB3(1), CREBBP(10), DVL1(1), DVL3(1), EP300(4), FZD2(2), GNAS(2), KRAS(2), MAPK1(1), MAPK3(1), PLCB1(6), PLCB4(3), PRKCA(3), RAF1(1), WNT7A(2), WNT8A(1), WNT9A(1)	601357	72	49	72	20	22	32	2	10	6	6.71e-06	0.00015
28	HSA02010_ABC_TRANSPORTERS_ GENERAL	Genes involved in ABC transporters - general	44	ABCA10(4), ABCA13(16), ABCA4(8), ABCA6(5), ABCA7(1), ABCB1(9), ABCB5(4), ABCC1(4), ABCC10(1), ABCC12(9), ABCC2(2), ABCC5(1), ABCC8(6), ABCC9(5), ABCG4(1), ABCG8(5)	616577	81	56	81	28	18	42	7	6	8	7.21e-06	0.00016
29	BLOOD_CLOTTING_CASCADE		21	F12(1), F5(5), FGG(1), LPA(6), VWF(12)	122623	25	23	25	6	6	13	0	1	5	9.29e-06	0.00020
30	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	19	AMPH(10), PICALM(2), PPP3CC(1), SYNJ2(1)	49330	14	14	14	4	4	6	0	0	4	0.000011	0.00022
31	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	16	CREBBP(10), EP300(4), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	81709	19	17	19	5	5	8	0	3	3	0.000019	0.00037
32	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	6	PLCB1(6), PRKCA(3), RELA(2)	31109	11	8	11	3	4	4	0	2	1	0.000029	0.00055
33	HSA04340_HEDGEHOG_ SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	56	CSNK1G1(2), GLI1(1), LRP2(22), STK36(4), WNT7A(2), WNT8A(1), WNT9A(1)	190483	33	26	33	10	8	20	1	2	2	0.000037	0.00068
34	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	21	F2RL3(1), ITGA1(1), MAPK1(1), MAPK3(1), PLA2G4A(4), PLCB1(6), PRKCA(3), PTK2(2), RAF1(1)	99287	20	16	20	6	7	8	0	3	2	0.000071	0.0013
35	SA_DIACYLGLYCEROL_ SIGNALING	DAG (diacylglycerol) signaling activity	10	PDE1A(2), PLCB1(6)	17214	8	7	8	2	4	3	0	1	0	0.000085	0.0015
36	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	7	CREBBP(10), EP300(4), MAPK1(1), MAPK3(1)	68251	16	15	16	3	3	8	0	2	3	0.000091	0.0016
37	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	13	APC(7), CDH1(1), CREBBP(10), EP300(4), MAPK3(1)	125820	23	21	23	3	3	12	1	3	4	0.000098	0.0016
38	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	19	ATM(4), BRCA1(5), RAD50(3), RAD51(1), RELA(2)	61094	15	12	15	2	2	9	0	2	2	0.00012	0.0019
39	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	11	COL4A1(6), COL4A3(2), COL4A4(6), COL4A6(2)	70228	16	14	16	7	7	7	1	0	1	0.00013	0.0020
40	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	22	CREBBP(10), EP300(4), IL1B(1), MAP2K6(2), MAP3K14(1), MYD88(1), RELA(2)	118678	21	19	21	8	6	8	0	2	5	0.00013	0.0020
41	G_PROTEIN_SIGNALING		92	ADCY2(11), ADCY3(3), ADCY4(3), ADCY5(2), ADCY8(8), AKAP11(4), AKAP9(5), GNAL(1), ITPR1(1), KRAS(2), PDE1A(2), PDE4A(1), PDE4C(1), PDE8A(2), PPP3CC(1), PRKCA(3), PRKCE(2), PRKCZ(1), PRKD3(2), USP5(1)	529834	56	42	56	15	12	24	1	11	8	0.00016	0.0023
42	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	137	CHAD(1), COL11A2(6), COL17A1(2), COL1A1(4), COL4A1(6), COL4A4(6), COL4A6(2), COL5A3(7), GJA10(3), GJB1(1), ITGB4(2), KRT13(1), KRT23(3), KRT3(2), KRT6B(3), KRT72(1), KRT74(1), KRT75(1), KRT76(1), KRT79(1), KRT9(1), LAMA1(7), LAMA2(10), LAMA3(6), LAMA5(5), LAMB1(5), LAMB2(3), LAMB4(3), NES(1), RELN(27), TNC(5), TNXB(12), VWF(12)	1610052	151	75	151	48	41	76	5	10	19	0.00016	0.0023
43	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	21	CD3E(1), CREBBP(10), GNAS(2), PTPRC(4)	77146	17	14	17	5	4	7	1	2	3	0.00017	0.0023
44	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	21	CD3E(1), CREBBP(10), GNAS(2), PTPRC(4)	77146	17	14	17	5	4	7	1	2	3	0.00017	0.0023
45	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	23	PIGG(2), PIGO(2), PIGQ(1)	14857	5	5	5	3	1	0	1	1	2	0.00018	0.0024
46	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	19	ABCB1(9), ATM(4)	47874	13	12	13	2	3	8	0	2	0	0.00021	0.0029
47	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	22	MAPK1(1), MAPK3(1), PLCB1(6), PRKCA(3), PTK2(2), SMPD2(3)	73231	16	14	16	3	6	6	1	2	1	0.00023	0.0030
48	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	12	ACE2(2), CMA1(1), COL4A1(6), COL4A3(2), COL4A4(6), COL4A6(2)	94012	19	17	19	7	7	10	1	0	1	0.00028	0.0036
49	HSA04080_NEUROACTIVE_ LIGAND_RECEPTOR_ INTERACTION	Genes involved in neuroactive ligand-receptor interaction	238	AVPR2(2), CALCR(2), CHRM1(1), CRHR1(3), CRHR2(1), CTSG(2), F2RL3(1), GABRA3(3), GABRG3(5), GABRR1(1), GLP2R(2), GPR156(1), GRIA1(5), GRIK5(2), GRIN2B(11), GRIN3B(1), GRM1(8), GRM2(3), GZMA(3), HTR1D(1), LEPR(8), NPFFR1(1), NPY1R(3), NTSR2(2), P2RX4(1), PARD3(3), PTH2R(4), RXFP1(6), TBXA2R(1), TRPV1(1)	822037	88	58	88	25	24	42	4	9	9	0.00031	0.0039
50	HSA04010_MAPK_SIGNALING_ PATHWAY	Genes involved in MAPK signaling pathway	248	ACVR1C(1), BRAF(4), CACNA1A(6), CACNA1C(14), CACNA1D(1), CACNA1E(14), CACNA1F(3), CACNA1G(4), CACNA1H(1), CACNA1I(7), CACNA2D2(2), CACNA2D4(1), CACNB2(3), CACNB4(2), CDC25B(2), ECSIT(1), EGFR(2), FLNA(4), FLNB(3), IL1B(1), KRAS(2), MAP2K5(1), MAP2K6(2), MAP3K1(4), MAP3K12(1), MAP3K14(1), MAP4K3(1), MAPK1(1), MAPK3(1), MAPK8IP1(4), MAPK8IP3(3), MAPKAPK5(1), MAX(1), MKNK2(1), NF1(14), NTRK1(5), PAK1(1), PDGFRB(5), PLA2G4A(4), PPP3CC(1), PRKCA(3), RAF1(1), RASA1(2), RASA2(2), RASGRF2(2), RASGRP3(2), RPS6KA2(2), RPS6KA4(2), SOS1(3), TAOK2(2), TNFRSF1A(2)	1658979	153	79	153	43	33	78	6	12	24	0.00032	0.0040
51	HSA00902_MONOTERPENOID_ BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	2	CYP2C19(6)	11065	6	6	6	2	2	3	0	0	1	0.00036	0.0043
52	ST_DIFFERENTIATION_ PATHWAY_IN_PC12_ CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	42	BRAF(4), CREB3(1), CREBBP(10), MAP1B(4), MAPK1(1), MAPK3(1), MAPK8IP1(4), MAPK8IP3(3), NTRK1(5), OPN1LW(1), PIK3C2G(1)	251749	35	33	35	11	11	16	0	3	5	0.00041	0.0048
53	HSA04630_JAK_STAT_ SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	152	CREBBP(10), CSF2RB(4), EP300(4), EPOR(1), IFNA16(2), IL10RA(1), IL11RA(1), IL12RB2(2), IL21R(2), IL22(1), IL22RA2(1), IL4(1), IL5RA(2), JAK2(3), LEPR(8), PIAS1(1), PIAS4(1), PIK3R5(4), PIM1(2), SOS1(3), STAT1(1), STAT5B(1), TPO(5)	538986	61	45	61	18	17	27	2	5	10	0.00041	0.0048
54	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	16	CREBBP(10), EP300(4), STAT5B(1)	70404	15	14	15	4	3	7	0	2	3	0.00045	0.0052
55	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	127	ABLIM1(2), ABLIM3(2), DPYSL5(4), EPHA2(2), EPHA3(5), EPHA6(7), EPHB2(3), KRAS(2), MAPK1(1), MAPK3(1), MET(2), NFAT5(1), NRP1(4), PAK1(1), PLXNA1(2), PLXNA2(1), PLXNB1(1), PLXNC1(2), PPP3CC(1), PTK2(2), RASA1(2), ROBO3(3), SEMA3B(2), SEMA3F(1), SEMA3G(1), SEMA4F(3), SEMA6B(1), SEMA6D(4), SEMA7A(3), SLIT1(4), SLIT3(8), SRGAP3(3)	731951	81	51	81	31	20	38	7	5	11	0.00053	0.0060
56	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	15	MAPK1(1), MAPK3(1), PLCB1(6), PRKCA(3), RAF1(1), RELA(2)	65690	14	11	14	4	5	6	0	2	1	0.00068	0.0075
57	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	10	ITGA1(1), LYN(1), SELP(6)	29128	8	8	8	1	1	4	0	0	3	0.00086	0.0093
58	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	6	CPS1(9)	27696	9	9	9	1	3	5	0	0	1	0.00093	0.0099
59	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	13	MYLK(1), PLCB1(6), PPP1R12B(1), PRKCA(3)	50901	11	10	11	4	4	4	0	2	1	0.0011	0.011
60	ST_GRANULE_CELL_ SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	25	APC(7), CREB3(1), EPHB2(3), MAPK1(1), MAPK8IP1(4), MAPK8IP3(3)	101412	19	18	19	1	5	10	1	2	1	0.0011	0.011
61	HSA00950_ALKALOID_ BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	5	DDC(3), TAT(3)	13232	6	6	6	1	2	4	0	0	0	0.0011	0.011
62	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	13	CREBBP(10), TNFRSF1A(2), TNFRSF1B(1)	84465	13	12	13	1	4	3	0	3	3	0.0012	0.012
63	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	10	AKAP9(5), PRKCE(2)	20276	7	7	7	2	1	5	0	1	0	0.0014	0.014
64	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	50	CD36(1), CREBBP(10), EP300(4), HSD17B4(1), MAPK1(1), MAPK3(1), NCOR1(4), NCOR2(3), PRKCA(3), RELA(2), STAT5B(1)	225272	31	27	31	9	8	14	1	3	5	0.0015	0.014
65	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	20	CD3E(1), CXCR3(1), IL12RB2(2), JAK2(3), MAP2K6(2)	40623	9	8	9	2	1	4	0	1	3	0.0015	0.014
66	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	11	CREBBP(10), DFFB(1), GZMA(3)	84774	14	13	14	1	5	4	0	2	3	0.0017	0.015
67	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	18	EGFR(2), MAPK1(1), MAPK3(1), PTPRB(9), RAF1(1), RASA1(2), SOS1(3)	109671	19	17	19	4	4	11	0	1	3	0.0019	0.017
68	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	22	COL4A1(6), COL4A3(2), COL4A4(6), COL4A6(2), F12(1), F5(5), FGG(1), SERPING1(2)	174863	25	20	25	10	8	12	1	0	4	0.0020	0.018
69	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	12	NTRK1(5), PRKCA(3), SOS1(3)	61862	11	11	11	1	0	7	0	2	2	0.0020	0.018
70	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	9	GPI(3), HK1(3), PGK1(2)	37507	8	7	8	0	5	2	0	0	1	0.0023	0.020
71	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	14	APC(7), CREBBP(10), DVL1(1), EP300(4)	149767	22	20	22	3	4	10	1	3	4	0.0025	0.022
72	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	10	ACACA(2), LEPR(8), PRKAG2(2)	57545	12	12	12	3	5	4	1	1	1	0.0027	0.023
73	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	22	JAK2(3), MAPK3(1), PRKCA(3), RAF1(1), RASA1(2), SOS1(3), STAT1(1), STAT5B(1)	108948	15	15	15	1	1	8	0	2	4	0.0030	0.025
74	HSA04640_HEMATOPOIETIC_ CELL_LINEAGE	Genes involved in hematopoietic cell lineage	86	CD19(1), CD1B(3), CD1C(4), CD1E(3), CD22(4), CD36(1), CD3E(1), CD5(1), CR1(2), CSF1R(2), EPOR(1), GP1BA(3), GP5(3), IL11RA(1), IL1B(1), IL4(1), IL5RA(2), ITGA1(1), ITGA2(5), ITGA5(1), ITGAM(2), TPO(5)	440406	48	33	48	16	13	29	2	0	4	0.0030	0.025
75	ST_T_CELL_SIGNAL_ TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	44	EPHB2(3), GRAP2(1), MAPK1(1), NFAT5(1), NFKBIL2(5), PAK1(1), PTPRC(4), RAF1(1), RASGRP3(2), SOS1(3), VAV1(5)	240795	27	22	27	6	9	10	4	4	0	0.0037	0.030
76	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	19	F2RL3(1), PLCB1(6), PPP1R12B(1), PRKCA(3)	67331	11	9	11	3	5	3	0	2	1	0.0037	0.030
77	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	34	APC(7), BRAF(4), EGFR(2), ITPR1(1), ITPR2(5), ITPR3(3), KCNJ9(3), MAPK1(1), RAF1(1)	191197	27	24	27	7	7	13	2	1	4	0.0041	0.033
78	ST_INTERLEUKIN_4_ PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	26	IL4(1), INPP5D(4), JAK2(3), SOS1(3)	56800	11	11	11	0	1	7	0	2	1	0.0042	0.033
79	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	24	POLD1(1), POLQ(6), REV1(4), REV3L(4)	84785	15	13	15	3	3	10	1	1	0	0.0043	0.033
80	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	15	CD3E(1), CXCR3(1), IL12RB2(2), JAK2(3)	29013	7	6	7	1	1	3	0	1	2	0.0044	0.034
81	GPCRDB_OTHER		53	CELSR1(10), CELSR2(4), CELSR3(6), CXCR3(1), EMR2(3), EMR3(5), GPR116(4), GPR143(1), GPR61(1), GPR84(1), GRM1(8), LGR6(1)	451592	45	31	45	15	6	23	6	2	8	0.0053	0.040
82	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	42	CD3E(1), MAP3K1(4), MAPK3(1), PPP3CC(1), PRKCA(3), RAF1(1), RASA1(2), RELA(2), SOS1(3), VAV1(5)	185779	23	22	23	3	5	9	1	3	5	0.0066	0.050
83	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	6	ABCB1(9), ABCC1(4)	69312	13	12	13	2	4	8	0	1	0	0.0074	0.055
84	HSA04320_DORSO_VENTRAL_ AXIS_FORMATION	Genes involved in dorso-ventral axis formation	28	BRAF(4), EGFR(2), KRAS(2), MAPK1(1), MAPK3(1), NOTCH1(6), NOTCH2(2), NOTCH3(3), NOTCH4(4), PIWIL3(2), RAF1(1), SOS1(3)	257157	31	26	31	10	4	18	2	2	5	0.0079	0.058
85	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	11	GNAS(2), PRKCA(3)	19909	5	5	5	2	0	3	0	1	1	0.010	0.074
86	HSA04610_COMPLEMENT_ AND_COAGULATION_ CASCADES	Genes involved in complement and coagulation cascades	69	C1QA(2), C2(2), C3(1), C6(11), C7(4), C9(2), CFB(1), CR1(2), F12(1), F13A1(1), F5(5), FGG(1), MASP2(1), SERPIND1(1), SERPING1(2), VWF(12)	548617	49	40	49	14	11	22	4	1	11	0.011	0.076
87	HSA05110_CHOLERA_ INFECTION	Genes involved in cholera - infection	41	ACTG2(3), ADCY3(3), ATP6V0A1(3), ATP6V0A2(5), ATP6V1G3(1), ATP6V1H(1), ERO1L(1), GNAS(2), PRKCA(3)	185836	22	19	22	4	4	11	0	4	3	0.013	0.092
88	ST_PHOSPHOINOSITIDE_ 3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	33	BTK(2), INPP5D(4), RPS6KA2(2), SOS1(3)	69184	11	11	11	0	1	7	0	2	1	0.013	0.094
89	NITROGEN_METABOLISM		21	CA6(3), CPS1(9)	70178	12	12	12	1	4	6	1	0	1	0.015	0.10
90	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	34	BLNK(1), BTK(2), LYN(1), MAP3K1(4), MAPK3(1), PPP3CC(1), PRKCA(3), RAF1(1), SOS1(3), VAV1(5)	181047	22	21	22	2	4	10	1	3	4	0.016	0.11
91	HSA04670_LEUKOCYTE_ TRANSENDOTHELIAL_ MIGRATION	Genes involved in Leukocyte transendothelial migration	110	ACTN3(2), CD99(1), CDH5(1), CTNND1(2), CYBB(2), GRLF1(2), ITGAL(2), ITGAM(2), OCLN(1), PIK3R5(4), PRKCA(3), PTK2(2), RHOH(5), VAV1(5), VCL(2)	327687	36	28	36	21	7	19	1	5	4	0.016	0.11
92	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	35	DOCK1(3), ITGA1(1), MAPK1(1), MAPK3(1), MET(2), PAK1(1), PTK2(2), RAF1(1), RASA1(2), SOS1(3)	122965	17	14	17	4	3	8	2	1	3	0.017	0.11
93	C21_STEROID_HORMONE_ METABOLISM		11	CYP11B1(5), CYP11B2(3)	45443	8	8	8	1	2	4	0	2	0	0.018	0.11
94	HSA00140_C21_STEROID_ HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	11	CYP11B1(5), CYP11B2(3)	45443	8	8	8	1	2	4	0	2	0	0.018	0.11
95	UREA_CYCLE_AND_METABOLISM_ OF_AMINO_GROUPS		20	CPS1(9), SMS(2)	60713	11	10	11	1	3	7	0	0	1	0.018	0.12
96	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	12	CSF1R(2), EGFR(2), MET(2), PRKCA(3), SH3KBP1(2)	89437	11	9	11	1	1	5	1	3	1	0.019	0.12
97	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	52	CAMK4(1), CREBBP(10), ELSPBP1(1), MAPK1(1), MAPK3(1), MYH2(14), PPP3CC(1), RAF1(1)	268692	30	25	30	7	8	14	0	3	5	0.021	0.13
98	HSA00534_HEPARAN_ SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	19	EXT2(1), EXTL1(1), NDST1(3), NDST2(3)	40965	8	8	8	3	1	5	0	1	1	0.021	0.13
99	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	13	C1QA(2), C2(2), C3(1), C6(11), C7(4), C9(2)	250721	22	20	22	6	3	10	3	0	6	0.021	0.13
100	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	22	BTK(2), EPHB2(3), F2RL3(1), MAP2K5(1), MAPK1(1), PLD3(1), PTK2(2), RAF1(1), VAV1(5)	135626	17	13	17	2	5	6	1	3	2	0.021	0.13
101	ST_DICTYOSTELIUM_ DISCOIDEUM_CAMP_ CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	32	ETFA(2), ITPR1(1), ITPR2(5), ITPR3(3), MAPK1(1), MAPK3(1), PAK1(1), PIK3C2G(1), RIPK3(1)	201122	16	16	16	7	5	5	0	0	6	0.022	0.13
102	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	16	CD3E(1), IL4(1)	3543	2	2	2	0	0	2	0	0	0	0.025	0.15
103	HSA00760_NICOTINATE_ AND_NICOTINAMIDE_ METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	22	ENPP3(3), NNT(4), NT5C2(1), NT5C3(2), NT5E(1)	71425	11	11	11	2	2	6	2	0	1	0.025	0.15
104	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	21	GNAS(2), MAPK1(1), MAPK3(1), PIK3C2G(1), PLCB1(6), PPP1R12B(1), PRKCA(3), PTK2(2), RAF1(1)	140986	18	16	18	10	6	8	0	2	2	0.025	0.15
105	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	16	C1QA(2), C2(2), C3(1), C6(11), C7(4), C9(2), MASP2(1)	258752	23	20	23	6	4	10	3	0	6	0.026	0.15
106	HSA00592_ALPHA_LINOLENIC_ ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	15	PLA2G4A(4)	15172	4	4	4	2	1	2	0	1	0	0.028	0.16
107	CYSTEINE_METABOLISM		8	CARS(3), LDHB(1), LDHC(1)	28349	5	5	5	0	0	3	1	0	1	0.028	0.16
108	HSA00272_CYSTEINE_ METABOLISM	Genes involved in cysteine metabolism	17	CARS(3), LDHB(1), LDHC(1)	28349	5	5	5	0	0	3	1	0	1	0.028	0.16
109	COMPLEMENT_ACTIVATION_ CLASSICAL		15	C1QA(2), C2(2), C3(1), C6(11), C7(4), C9(2)	260576	22	20	22	8	3	10	3	0	6	0.028	0.16
110	HSA04370_VEGF_SIGNALING_ PATHWAY	Genes involved in VEGF signaling pathway	69	KRAS(2), MAPK1(1), MAPK3(1), NFAT5(1), NOS3(1), PIK3R5(4), PLA2G4A(4), PPP3CC(1), PRKCA(3), PTK2(2), RAF1(1)	192376	21	20	21	8	4	10	0	3	4	0.029	0.17
111	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	6	LDLR(3)	11475	3	3	3	0	1	1	0	1	0	0.030	0.17
112	HSA00061_FATTY_ACID_ BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	6	ACACA(2), ACACB(6)	40666	8	7	8	3	2	6	0	0	0	0.032	0.18
113	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	23	APC(7), CREBBP(10), CTBP1(1), DVL1(1)	178659	19	17	19	1	4	7	1	3	4	0.035	0.19
114	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	17	PRKCA(3)	15591	3	3	3	1	0	1	0	1	1	0.036	0.19
115	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	4	PRKCA(3)	15591	3	3	3	1	0	1	0	1	1	0.036	0.19
116	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	11	ITGAL(2), ITGAM(2), SELL(1), SELP(6)	74250	11	10	11	6	3	6	0	0	2	0.037	0.20
117	INTEGRIN_MEDIATED_ CELL_ADHESION_KEGG		90	CAPN1(2), CAPN11(1), CAPN3(3), CAPN5(3), DOCK1(3), ITGA2(5), ITGA5(1), ITGA7(2), ITGA8(8), ITGAD(7), ITGAL(2), ITGAM(2), ITGB4(2), ITGB6(1), MAP2K6(2), PAK1(1), PTK2(2), RAPGEF1(2), RHO(1), SDCCAG8(5), SORBS1(4), SOS1(3), TLN1(3), VCL(2)	718652	67	47	67	20	18	36	6	1	6	0.038	0.20
118	DNA_POLYMERASE		7	POLD1(1), POLQ(6)	39944	7	6	7	1	1	5	0	1	0	0.038	0.20
119	HSA04520_ADHERENS_ JUNCTION	Genes involved in adherens junction	75	ACTN3(2), ACVR1C(1), CDH1(1), CREBBP(10), CTNND1(2), EGFR(2), EP300(4), FARP2(1), INSR(2), MAPK1(1), MAPK3(1), MET(2), PARD3(3), PTPRB(9), PTPRF(4), PTPRJ(2), PTPRM(5), PVRL1(4), PVRL3(1), SORBS1(4), VCL(2), WASF3(1), WASL(1), YES1(2)	763856	67	45	67	20	13	35	2	9	8	0.039	0.20
120	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	18	JAK2(3), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	55018	8	7	8	1	2	3	0	2	1	0.040	0.21
121	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	9	CDC25B(2), PRKCA(3)	32755	5	5	5	1	0	2	1	1	1	0.044	0.22
122	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	15	NTRK1(5), SOS1(3)	55847	8	8	8	1	0	6	0	1	1	0.047	0.24
123	PROSTAGLANDIN_AND_ LEUKOTRIENE_METABOLISM		31	PLA2G4A(4), PRDX2(1), TPO(5)	64806	10	10	10	4	3	5	0	1	1	0.048	0.24
124	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	22	ATM(4), BRCA1(5), CDC25B(2), EP300(4), PRKDC(4)	158071	19	17	19	4	3	10	1	2	3	0.050	0.25
125	HSA01040_POLYUNSATURATED_ FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	13	HSD17B12(1)	3178	1	1	1	0	0	0	0	0	1	0.052	0.26
126	HSA00910_NITROGEN_ METABOLISM	Genes involved in nitrogen metabolism	24	CA6(3), CPS1(9)	85086	12	12	12	1	4	6	1	0	1	0.052	0.26
127	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	7	CD36(1)	6029	1	1	1	1	0	0	1	0	0	0.053	0.26
128	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	20	IL16(4), IL4(1)	25265	5	5	5	0	3	2	0	0	0	0.055	0.26
129	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	16	ATM(4), CDK4(1)	28188	5	5	5	0	2	2	0	1	0	0.055	0.26
130	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	22	IRAK1(4), MAP3K1(4), MAP3K14(1), MYD88(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	148769	15	13	15	5	6	4	1	2	2	0.057	0.27
131	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	12	GABRA3(3)	10755	3	3	3	0	0	3	0	0	0	0.059	0.28
132	HSA00680_METHANE_ METABOLISM	Genes involved in methane metabolism	10	TPO(5)	28868	5	5	5	1	1	3	0	0	1	0.061	0.28
133	HSA00940_PHENYLPROPANOID_ BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	7	TPO(5)	28868	5	5	5	1	1	3	0	0	1	0.061	0.28
134	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	37	BTK(2), LYN(1), MAP3K1(4), MAPK1(1), MAPK3(1), PLA2G4A(4), PPP3CC(1), RAF1(1), SOS1(3), VAV1(5)	204355	23	21	23	4	5	11	1	3	3	0.061	0.28
135	HSA00401_NOVOBIOCIN_ BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	3	TAT(3)	10582	3	3	3	1	1	2	0	0	0	0.062	0.28
136	STARCH_AND_SUCROSE_ METABOLISM		44	AGL(2), ENPP3(3), GANAB(4), GPI(3), GYS1(1), GYS2(2), HK1(3), MGAM(7), PGM1(1), UGT1A7(1), UGT2B15(2)	273958	29	24	29	10	9	13	1	2	4	0.065	0.30
137	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	6	PER1(4)	18600	4	3	4	0	1	3	0	0	0	0.066	0.30
138	HSA04150_MTOR_SIGNALING_ PATHWAY	Genes involved in mTOR signaling pathway	44	BRAF(4), EIF4B(2), MAPK1(1), MAPK3(1), PIK3R5(4), RPS6KA2(2), TSC2(2), ULK2(1)	137632	17	16	17	6	4	10	0	1	2	0.066	0.30
139	HSA04514_CELL_ADHESION_ MOLECULES	Genes involved in cell adhesion molecules (CAMs)	130	CD22(4), CD99(1), CDH1(1), CDH3(1), CDH5(1), CNTN1(7), ICAM3(1), ITGA8(8), ITGAL(2), ITGAM(2), MAG(1), NLGN2(1), NRCAM(3), OCLN(1), PTPRC(4), PTPRF(4), PTPRM(5), PVRL1(4), PVRL3(1), SELL(1), SELP(6), VCAN(12)	802216	71	46	71	21	15	43	5	1	7	0.067	0.30
140	SIG_PIP3_SIGNALING_ IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	33	BTK(2), CD19(1), ITPR1(1), ITPR2(5), ITPR3(3), LYN(1), PTPRC(4), RPS6KA2(2), VAV1(5)	240800	24	22	24	7	6	9	2	3	4	0.069	0.30
141	HSA04330_NOTCH_SIGNALING_ PATHWAY	Genes involved in Notch signaling pathway	43	CREBBP(10), CTBP1(1), CTBP2(1), DLL3(2), DTX2(1), DVL1(1), DVL3(1), EP300(4), HDAC2(1), NCOR2(3), NCSTN(3), NOTCH1(6), NOTCH2(2), NOTCH3(3), NOTCH4(4)	444984	43	32	43	11	8	23	2	4	6	0.070	0.31
142	PANTOTHENATE_AND_ COA_BIOSYNTHESIS		12	DPYS(2), ENPP3(3), PANK3(1), PANK4(2)	59870	8	8	8	0	2	4	0	2	0	0.071	0.31
143	SA_B_CELL_RECEPTOR_ COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	24	BLNK(1), LYN(1), MAP3K1(4), MAPK1(1), MAPK3(1), MAPK8IP3(3), SOS1(3), VAV1(5)	152605	19	19	19	2	5	10	1	2	1	0.072	0.31
144	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	28	CXCR3(1), IL12RB2(2), IL4(1)	19709	4	4	4	1	1	2	0	0	1	0.075	0.32
145	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	7	LDLR(3)	17745	3	3	3	0	1	1	0	1	0	0.078	0.33
146	HSA04740_OLFACTORY_ TRANSDUCTION	Genes involved in olfactory transduction	30	ADCY3(3), CAMK2A(2), CAMK2D(1), CLCA4(2), CNGB1(3), GNAL(1)	145273	12	12	12	2	6	2	0	2	2	0.080	0.34
147	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	9	GABRA3(3), PRKCE(2)	23876	5	5	5	0	1	4	0	0	0	0.083	0.35
148	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	7	ATM(4)	21839	4	4	4	0	1	2	0	1	0	0.086	0.35
149	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	43	EGFR(2), MAP2K6(2), MAP3K1(4), MAP3K14(1), MAPK1(1), MAPK3(1), PRKCA(3), PRKCE(2), RAF1(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	226611	22	20	22	7	7	9	0	2	4	0.086	0.35
150	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	7	AKAP13(4)	22005	4	4	4	1	1	2	0	1	0	0.086	0.35
151	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	13	F5(5), FGG(1)	41492	6	6	6	2	1	3	0	0	2	0.087	0.35
152	ST_ERK1_ERK2_MAPK_ PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	29	BRAF(4), CREB3(1), MAPK1(1), MAPK3(1), MKNK2(1), RPS6KA2(2), SOS1(3)	128758	13	13	13	3	1	11	0	1	0	0.088	0.36
153	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	26	BRCA1(5), CREBBP(10), EP300(4), HDAC2(1), NCOR2(3), NR0B1(1), POLR2A(2)	349597	26	22	26	5	6	10	0	5	5	0.089	0.36
154	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	17	IL12RB2(2), IL4(1)	16272	3	3	3	1	0	2	0	0	1	0.089	0.36
155	APOPTOSIS_GENMAPP		42	BAK1(1), MAP3K1(4), MAP3K14(1), PARP1(2), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	136283	13	12	13	6	5	4	0	1	3	0.091	0.36
156	GLUCOCORTICOID_MINERALOCORTICOID_ METABOLISM		8	CYP11B2(3)	26788	3	3	3	1	0	1	0	2	0	0.092	0.36
157	ST_INTERFERON_GAMMA_ PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	9	JAK2(3), PTPRU(3), STAT1(1)	54370	7	6	7	1	0	5	0	1	1	0.093	0.36
158	OVARIAN_INFERTILITY_ GENES		25	ATM(4), CDK4(1), INHA(3), MLH1(2), MSH5(1), NCOR1(4), ZP2(3)	157012	18	15	18	1	5	8	2	1	2	0.093	0.36
159	SIG_CHEMOTAXIS	Genes related to chemotaxis	44	ARHGEF11(7), BTK(2), ITPR1(1), ITPR2(5), ITPR3(3), MYLK(1), PAK1(1), RHO(1), WASL(1)	286271	22	18	22	6	8	8	1	0	5	0.094	0.36
160	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	18	PPP3CC(1), PRKCA(3)	52885	4	4	4	0	0	1	0	1	2	0.095	0.36
161	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	33	MAPK1(1), MAPK3(1), MAPK8IP1(4), MAPK8IP3(3), MAPKAPK5(1), NFKBIL2(5)	137448	15	15	15	3	6	6	1	1	1	0.095	0.36
162	BIOGENIC_AMINE_SYNTHESIS		15	DDC(3), PAH(2)	30650	5	5	5	0	3	2	0	0	0	0.096	0.36
163	ST_INTEGRIN_SIGNALING_ PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	78	ARHGEF6(1), BRAF(4), DOCK1(3), EPHB2(3), GRLF1(2), ITGA1(1), ITGA2(5), ITGA5(1), ITGA7(2), ITGA8(8), MAP3K11(1), MAPK1(1), MAPK8IP1(4), MAPK8IP3(3), MYLK(1), PAK1(1), PTK2(2), RAF1(1), RHO(1), SOS1(3), TLN1(3), TLN2(2)	625106	53	41	53	22	17	30	2	1	3	0.098	0.37
164	GALACTOSE_METABOLISM		24	GALT(1), GANAB(4), HK1(3), MGAM(7), PFKP(2), PGM1(1)	162622	18	16	18	5	5	10	0	1	2	0.099	0.37
165	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	8	IL4(1)	1601	1	1	1	0	0	1	0	0	0	0.10	0.38
166	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	16	IL4(1)	1601	1	1	1	0	0	1	0	0	0	0.10	0.38
167	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	29	IL4(1)	1601	1	1	1	0	0	1	0	0	0	0.10	0.38
168	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	15	IL4(1)	1601	1	1	1	0	0	1	0	0	0	0.10	0.38
169	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	6	NRG2(2), PRKCA(3)	39039	5	5	5	0	0	3	0	1	1	0.10	0.38
170	ST_WNT_CA2_CYCLIC_ GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	19	CAMK2A(2), CAMK2D(1), ITPR1(1), ITPR2(5), ITPR3(3), NFAT5(1), PDE6A(2), PDE6B(1)	178205	16	16	16	5	7	5	1	0	3	0.11	0.38
171	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	11	JAK2(3), PTPRU(3)	46377	6	6	6	1	0	4	0	1	1	0.11	0.38
172	METHANE_METABOLISM		13	PRDX2(1), TPO(5)	43333	6	6	6	2	2	3	0	0	1	0.11	0.38
173	STILBENE_COUMARINE_ AND_LIGNIN_BIOSYNTHESIS		10	PRDX2(1), TPO(5)	43333	6	6	6	2	2	3	0	0	1	0.11	0.38
174	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	9	JAK2(3), PIAS1(1), PTPRU(3)	48492	7	7	7	1	1	4	0	1	1	0.11	0.38
175	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	37	MAP2K6(2), MAP3K1(4), MAPK1(1), MAPK3(1), PAK1(1), PIK3C2G(1), PLCB1(6), PPP3CC(1), RAF1(1), RELA(2)	227565	20	17	20	9	8	7	0	1	4	0.11	0.38
176	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	4	PRKCA(3)	23703	3	3	3	1	0	1	0	1	1	0.11	0.38
177	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	27	ITPR1(1), ITPR2(5), ITPR3(3), NFKBIL2(5), PLD3(1)	177118	15	15	15	5	6	4	1	1	3	0.11	0.39
178	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	17	GNAS(2), PRKAG2(2)	22804	4	4	4	2	1	2	0	0	1	0.11	0.39
179	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	52	BAG4(1), CFLAR(1), DFFB(1), MAP3K1(4), MAP3K14(1), PRKDC(4), PTK2(2), RASA1(2), RELA(2), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(1)	331822	23	21	23	7	8	8	0	1	6	0.12	0.41
180	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	15	CSF2RB(4), JAK2(3), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	106400	13	13	13	3	3	8	0	1	1	0.12	0.41
181	ST_B_CELL_ANTIGEN_ RECEPTOR	B cell receptors bind antigens and promote B cell activation.	39	BLNK(1), BTK(2), CD19(1), EPHB2(3), LYN(1), MAPK1(1), NFAT5(1), NFKBIL2(5), RAF1(1), SOS1(3), VAV1(5)	251198	24	20	24	5	5	12	2	4	1	0.12	0.41
182	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	17	CD3E(1)	1942	1	1	1	0	0	1	0	0	0	0.12	0.41
183	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	13	CD3E(1)	1942	1	1	1	0	0	1	0	0	0	0.12	0.41
184	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	6	CD3E(1)	1942	1	1	1	0	0	1	0	0	0	0.12	0.41
185	TCRMOLECULE	T Cell Receptor and CD3 Complex	3	CD3E(1)	1942	1	1	1	0	0	1	0	0	0	0.12	0.41
186	SIG_BCR_SIGNALING_ PATHWAY	Members of the BCR signaling pathway	46	BLNK(1), BTK(2), CD19(1), CD22(4), INPP5D(4), ITPR1(1), ITPR2(5), ITPR3(3), LYN(1), MAPK1(1), MAPK3(1), PPP3CC(1), PTPRC(4), RAF1(1), SOS1(3), VAV1(5)	395007	38	33	38	9	10	17	3	3	5	0.13	0.42
187	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	7	JAK2(3)	29641	3	3	3	0	0	1	0	1	1	0.14	0.44
188	ST_INTERLEUKIN_13_ PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	7	JAK2(3)	29641	3	3	3	0	0	1	0	1	1	0.14	0.44
189	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	11	GNAS(2)	9709	2	2	2	2	0	2	0	0	0	0.14	0.44
190	PHENYLALANINE_METABOLISM		22	ALDH3A1(1), AOC2(1), DDC(3), PRDX2(1), TAT(3), TPO(5)	129129	14	13	14	5	4	7	1	0	2	0.14	0.44
191	HSA04110_CELL_CYCLE	Genes involved in cell cycle	110	ANAPC4(2), ATM(4), CDC25B(2), CDK4(1), CREBBP(10), EP300(4), HDAC2(1), ORC3L(1), PRKDC(4), RBL1(4), SMC1A(2)	406210	35	27	35	10	9	14	3	4	5	0.14	0.44
192	SELENOAMINO_ACID_ METABOLISM		12	MARS(1), MAT1A(1), PAPSS2(1), SCLY(1)	29022	4	3	4	1	1	2	0	1	0	0.15	0.47
193	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	22	JAK2(3), MAP3K1(4), MAPK3(1), RAF1(1), SOS1(3), STAT1(1), STAT5B(1)	118969	14	14	14	2	3	8	0	1	2	0.15	0.47
194	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	9	HK1(3), PGM1(1)	56996	4	4	4	0	4	0	0	0	0	0.15	0.47
195	HSA00591_LINOLEIC_ ACID_METABOLISM	Genes involved in linoleic acid metabolism	31	CYP2C19(6), PLA2G4A(4)	78868	10	10	10	8	3	5	0	1	1	0.15	0.47
196	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	11	EPOR(1), JAK2(3), RELA(2)	62158	6	4	6	1	1	2	0	1	2	0.15	0.48
197	HSA04012_ERBB_SIGNALING_ PATHWAY	Genes involved in ErbB signaling pathway	85	ARAF(1), BRAF(4), CAMK2A(2), CAMK2D(1), EGFR(2), ERBB3(2), KRAS(2), MAPK1(1), MAPK3(1), NRG2(2), PAK1(1), PIK3R5(4), PRKCA(3), PTK2(2), RAF1(1), SOS1(3), STAT5B(1)	350789	33	29	33	11	9	18	0	2	4	0.16	0.48
198	LYSINE_DEGRADATION		31	ALDH3A1(1), DLST(1), DOT1L(2), GCDH(1)	137776	5	5	5	2	0	0	3	1	1	0.16	0.48
199	HSA00271_METHIONINE_ METABOLISM	Genes involved in methionine metabolism	17	DNMT1(3), MARS(1), MAT1A(1), TAT(3)	64416	8	8	8	2	1	6	0	1	0	0.16	0.48
200	HSA04070_PHOSPHATIDYLINOSITOL_ SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	73	INPP5B(2), INPP5D(4), ITPR1(1), ITPR2(5), ITPR3(3), PI4KA(3), PIK3C2A(1), PIK3C2B(5), PIK3C2G(1), PIK3R5(4), PIP5K1C(1), PLCB1(6), PLCB4(3), PLCE1(6), PRKCA(3), SYNJ2(1)	566037	49	37	49	15	12	25	1	4	7	0.16	0.48
201	1_2_DICHLOROETHANE_ DEGRADATION		8	ALDH3A1(1)	7017	1	1	1	0	0	0	0	0	1	0.16	0.48
202	ASCORBATE_AND_ALDARATE_ METABOLISM		8	ALDH3A1(1)	7017	1	1	1	0	0	0	0	0	1	0.16	0.48
203	HSA00053_ASCORBATE_ AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	9	ALDH3A1(1)	7017	1	1	1	0	0	0	0	0	1	0.16	0.48
204	HSA04350_TGF_BETA_ SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	89	ACVR1C(1), ACVRL1(2), BMPR1A(2), CREBBP(10), EP300(4), INHBC(1), MAPK1(1), MAPK3(1), NODAL(2), PPP2R2A(1), RBL1(4), SMURF2(1), ZFYVE16(1)	418180	31	29	31	4	6	13	2	5	5	0.16	0.49
205	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	11	CAPN1(2)	9989	2	2	2	0	1	1	0	0	0	0.17	0.51
206	HSA00150_ANDROGEN_ AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	54	ARSE(2), CYP11B1(5), CYP11B2(3), CYP19A1(3), HSD17B12(1), UGT1A7(1), UGT2B15(2), WBSCR22(1)	192556	18	17	18	2	7	7	1	2	1	0.17	0.52
207	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	23	MAPK1(1), MAPK3(1), PIK3C2G(1), PRKCA(3), PTK2(2), RAF1(1), RELA(2)	98923	11	9	11	7	3	5	0	1	2	0.18	0.52
208	IFNGPATHWAY	IFN gamma signaling pathway	6	JAK2(3), STAT1(1)	37634	4	4	4	0	0	2	0	1	1	0.18	0.52
209	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	13	IL10RA(1), IL22(1), IL22RA2(1), JAK2(3), STAT1(1), STAT5B(1)	77011	8	8	8	3	1	4	0	1	2	0.18	0.53
210	HSA00400_PHENYLALANINE_ TYROSINE_AND_TRYPTOPHAN_ BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	9	PAH(2), TAT(3)	38582	5	5	5	1	3	2	0	0	0	0.19	0.54
211	ANDROGEN_AND_ESTROGEN_ METABOLISM		30	ARSE(2), CYP11B1(5), CYP11B2(3), UGT1A7(1), UGT2B15(2)	148732	13	13	13	1	5	5	1	2	0	0.19	0.54
212	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	28	MAP3K1(4), MAPK1(1), MAPK3(1), PAK1(1), PRKCA(3), RAF1(1), SOS1(3)	124133	14	14	14	3	4	7	0	1	2	0.19	0.54
213	HSA04810_REGULATION_ OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	203	ACTN3(2), APC(7), ARAF(1), ARHGEF4(1), ARHGEF6(1), BRAF(4), CHRM1(1), CYFIP2(3), DOCK1(3), EGFR(2), FGD1(2), FGD3(4), GRLF1(2), ITGA1(1), ITGA2(5), ITGA5(1), ITGA7(2), ITGA8(8), ITGAD(7), ITGAL(2), ITGAM(2), ITGB4(2), ITGB6(1), KRAS(2), MAPK1(1), MAPK3(1), MYH10(2), MYH14(4), MYLK(1), NCKAP1L(4), PAK1(1), PDGFRB(5), PIK3R5(4), PIP5K1C(1), PPP1R12B(1), PTK2(2), RAF1(1), SOS1(3), TIAM2(1), TMSL3(1), VAV1(5), VCL(2), WASL(1)	1322909	107	68	107	36	28	53	6	8	12	0.19	0.54
214	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	12	BRAF(4), CREB3(1), MAPK1(1), RAF1(1)	50774	7	7	7	3	2	5	0	0	0	0.19	0.55
215	PEPTIDE_GPCRS		66	ATP8A1(5), AVPR2(2), CXCR3(1), GALT(1), NPY1R(3), NTSR2(2)	135133	14	13	14	2	2	10	0	1	1	0.20	0.57
216	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	16	ADAM12(2), EGFR(2), PRKCA(3), RELA(2)	81809	9	8	9	3	2	4	1	1	1	0.20	0.57
217	HSA04210_APOPTOSIS	Genes involved in apoptosis	82	ATM(4), CAPN1(2), CASP10(2), CFLAR(1), CSF2RB(4), DFFB(1), IL1B(1), IRAK1(4), MAP3K14(1), MYD88(1), NTRK1(5), PIK3R5(4), PPP3CC(1), RELA(2), TNFRSF1A(2)	386919	35	28	35	13	10	17	1	3	4	0.20	0.57
218	NICOTINATE_AND_NICOTINAMIDE_ METABOLISM		13	ENPP3(3), NNT(4), NT5E(1)	63666	8	8	8	2	2	5	0	0	1	0.20	0.57
219	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	10	IL1B(1), IL4(1), IL5RA(2)	24551	4	4	4	1	1	3	0	0	0	0.20	0.57
220	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	22	MAP3K1(4), MYLK(1), PAK1(1), PPP1R12B(1), RALBP1(1), TRIO(3), VAV1(5)	183219	16	14	16	6	5	6	1	3	1	0.21	0.57
221	APOPTOSIS_KEGG		48	CASP10(2), DFFB(1), NTRK1(5), PTPN13(2), SFRS2IP(1), TNFRSF1A(2), TNFRSF1B(1)	144217	14	14	14	2	2	8	0	2	2	0.21	0.57
222	HSA00565_ETHER_LIPID_ METABOLISM	Genes involved in ether lipid metabolism	30	AGPAT4(1), ENPP2(3), PLA2G4A(4)	69005	8	8	8	8	1	5	0	1	1	0.21	0.57
223	METHIONINE_METABOLISM		12	DNMT1(3), MARS(1), MAT1A(1)	45467	5	5	5	1	0	4	0	1	0	0.21	0.57
224	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	37	CAMK2A(2), CAMK2D(1), JAK2(3), MAPK1(1), MAPK3(1), MYLK(1), PRKCA(3), RAF1(1), SOS1(3), STAT1(1)	169961	17	17	17	6	4	9	0	2	2	0.21	0.57
225	HSA00310_LYSINE_ DEGRADATION	Genes involved in lysine degradation	47	ALDH3A1(1), DLST(1), DOT1L(2), GCDH(1), HSD17B4(1), SETD1A(5)	227317	11	11	11	5	1	4	4	1	1	0.21	0.57
226	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	10	GSR(2), RELA(2)	53442	4	3	4	1	1	1	0	2	0	0.21	0.58
227	HSA00520_NUCLEOTIDE_ SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	6	GALT(1)	3300	1	1	1	0	0	1	0	0	0	0.21	0.58
228	NUCLEOTIDE_SUGARS_ METABOLISM		5	GALT(1)	3300	1	1	1	0	0	1	0	0	0	0.21	0.58
229	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	32	IRAK1(4), MAP2K6(2), MAP3K1(4), MAP3K14(1), MYD88(1), RELA(2), TLR9(1), TOLLIP(1)	201970	16	14	16	6	6	5	1	1	3	0.22	0.60
230	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	29	EGFR(2), GNAS(2), MAPK1(1), MAPK3(1), MKNK2(1), RAF1(1), SOS1(3)	112885	11	11	11	5	2	9	0	0	0	0.23	0.60
231	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	13	EP300(4), NOS3(1)	45322	5	5	5	3	0	5	0	0	0	0.23	0.60
232	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	21	MAP3K1(4), MAPK1(1), MAPK3(1), RAF1(1), RELA(2), TNFRSF1A(2)	103899	11	10	11	3	5	5	0	0	1	0.23	0.60
233	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	21	ATM(4), BRCA1(5), RAD1(1), RAD50(3), RAD51(1)	163542	14	12	14	1	1	9	0	2	2	0.23	0.60
234	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	18	EP300(4), HDAC2(1), PPP3CC(1), PRKCA(3)	121933	9	9	9	5	0	5	0	2	2	0.23	0.60
235	PURINE_METABOLISM		110	ADA(1), ADCY2(11), ADCY3(3), ADCY4(3), ADCY5(2), ADCY8(8), ENPP3(3), GUCY2C(3), GUCY2D(1), NT5E(1), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4C(1), PDE6B(1), PDE8A(2), PFAS(5), POLD1(1), POLQ(6), POLR2A(2), POLR2F(1), RRM1(1)	903203	60	42	59	18	14	30	3	10	3	0.24	0.62
236	CIRCADIAN_EXERCISE		40	HERPUD1(1), PER1(4), ZFR(4)	81059	9	8	9	1	2	5	0	1	1	0.24	0.62
237	HSA00670_ONE_CARBON_ POOL_BY_FOLATE	Genes involved in one carbon pool by folate	16	ALDH1L1(2), MTHFD1L(1)	28439	3	3	3	1	0	2	0	1	0	0.24	0.62
238	ONE_CARBON_POOL_ BY_FOLATE		15	ALDH1L1(2), MTHFD1L(1)	28439	3	3	3	1	0	2	0	1	0	0.24	0.62
239	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	10	CR1(2), FCGR2B(2), ITGAL(2), PTPRC(4)	98937	10	10	10	4	4	5	1	0	0	0.24	0.62
240	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	34	GNAS(2), MAPK3(1), PPP3CC(1), PRKCA(3), RAF1(1)	87694	8	8	8	3	1	4	0	1	2	0.24	0.62
241	SA_MMP_CYTOKINE_ CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	15	FCGR3A(2), IL1B(1), SELL(1), TNFRSF1A(2), TNFRSF1B(1)	76010	7	7	7	1	3	2	0	1	1	0.24	0.62
242	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	27	MAP3K1(4), PPP3CC(1), RELA(2)	80041	7	6	7	3	3	2	0	0	2	0.24	0.62
243	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	20	KLRC3(1), MAPK3(1), PAK1(1), VAV1(5)	98338	8	7	8	1	2	3	1	2	0	0.25	0.64
244	HSA04710_CIRCADIAN_ RHYTHM	Genes involved in circadian rhythm	11	PER1(4), PER3(2)	56477	6	5	6	3	2	3	0	1	0	0.25	0.64
245	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	18	IL4(1), MAP3K1(4), RELA(2)	60131	7	5	7	3	3	3	0	0	1	0.26	0.64
246	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	18	MAP3K1(4), MAP3K14(1), RELA(2), TNFRSF1B(1)	103223	8	7	8	4	3	2	0	1	2	0.26	0.64
247	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	26	MAP3K1(4), MAPK3(1), PRKCA(3), RAF1(1), RASA1(2), SOS1(3), STAT1(1)	201694	15	15	15	2	3	7	0	1	4	0.26	0.65
248	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	10	CD3E(1), PTPRC(4)	44710	5	5	5	2	1	3	1	0	0	0.26	0.65
249	SA_PROGRAMMED_CELL_ DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	12	BAK1(1)	8259	1	1	1	0	1	0	0	0	0	0.26	0.65
250	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	31	IL1B(1), IRAK1(4), MAP2K6(2), MAP3K1(4), MAP3K14(1), MYD88(1), RELA(2), TOLLIP(1)	230805	16	14	16	8	7	4	1	1	3	0.27	0.65
251	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	26	CAMK2A(2), CAMK2D(1), GNAS(2), MAPK1(1), MAPK3(1), PRKCA(3), SOS1(3)	122035	13	13	13	4	3	8	0	1	1	0.27	0.66
252	RIBOFLAVIN_METABOLISM		10	ACPP(1), ENPP3(3)	30603	4	4	4	0	2	2	0	0	0	0.27	0.67
253	HSA04920_ADIPOCYTOKINE_ SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	71	ACACB(6), ACSL3(1), ADIPOR1(2), CAMKK1(2), CD36(1), IRS4(3), JAK2(3), LEPR(8), PRKAG2(2), RELA(2), SLC2A4(1), TNFRSF1A(2), TNFRSF1B(1)	412001	34	27	34	6	11	15	3	3	2	0.28	0.68
254	HSA04310_WNT_SIGNALING_ PATHWAY	Genes involved in Wnt signaling pathway	146	APC(7), CAMK2A(2), CAMK2D(1), CHD8(6), CREBBP(10), CTBP1(1), CTBP2(1), DAAM1(2), DVL1(1), DVL3(1), EP300(4), FZD2(2), LRP5(3), LRP6(1), NFAT5(1), PLCB1(6), PLCB4(3), PPP2R2A(1), PPP3CC(1), PRKCA(3), SENP2(1), WNT7A(2), WNT8A(1), WNT9A(1)	836151	62	42	62	17	15	28	3	7	9	0.28	0.68
255	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	8	SOS1(3)	21786	3	3	3	1	0	3	0	0	0	0.29	0.69
256	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	26	APC(7), DVL1(1), IRAK1(4), MYD88(1), RELA(2), TOLLIP(1)	193783	16	15	16	2	5	6	2	2	1	0.29	0.69
257	GLYCINE_SERINE_AND_ THREONINE_METABOLISM		37	AGXT2(3), AOC2(1), DLD(1), GLDC(3), SARDH(3)	177000	11	11	11	4	3	5	3	0	0	0.29	0.69
258	HSA04662_B_CELL_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in B cell receptor signaling pathway	63	BLNK(1), BTK(2), CD19(1), CD22(4), FCGR2B(2), INPP5D(4), KRAS(2), LYN(1), NFAT5(1), PIK3R5(4), PPP3CC(1), RASGRP3(2), VAV1(5)	392519	30	26	30	8	7	12	3	4	4	0.29	0.69
259	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	35	ARHGEF11(7), LPA(6), MAP3K1(4), NFKBIL2(5), PLD3(1), PTK2(2), TBXA2R(1)	312077	26	20	26	7	9	12	2	1	2	0.29	0.69
260	ARGININE_AND_PROLINE_ METABOLISM		43	ALDH3A1(1), AOC2(1), CPS1(9), NOS3(1), SMS(2)	142334	14	12	14	4	3	8	1	0	2	0.29	0.69
261	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	13	MAP3K1(4), MAP3K14(1), RELA(2)	92143	7	6	7	4	3	2	0	0	2	0.30	0.70
262	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	16	MAP2K6(2), MAP3K1(4), MAPK1(1), MAPK3(1), RELA(2)	100137	10	9	10	3	3	5	0	0	2	0.30	0.71
263	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	7	JAK2(3), MAPK1(1), MAPK3(1)	60037	5	5	5	0	0	3	0	1	1	0.30	0.71
264	CALCINEURIN_NF_AT_ SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	92	CAMK4(1), CD3E(1), CREBBP(10), EP300(4), FCGR3A(2), GRLF1(2), IL1B(1), IL4(1), NFAT5(1), PAK1(1), PPP3CC(1), PTPRC(4), RELA(2), VAV1(5), XPO5(1)	496441	37	26	37	15	10	15	2	4	6	0.30	0.71
265	INOSITOL_PHOSPHATE_ METABOLISM		23	PIK3C2A(1), PIK3C2B(5), PIK3C2G(1), PLCB1(6), PLCB4(3)	155169	16	15	16	7	4	8	1	1	2	0.30	0.71
266	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	57	ASH1L(5), ASH2L(1), DOT1L(2), EZH1(2), JMJD6(1), KDM6A(4), MEN1(1), MLL(2), MLL4(3), OGT(2), SETD1A(5), SETD2(4), WHSC1L1(3)	538096	35	27	35	9	3	18	3	4	7	0.31	0.71
267	HSA01031_GLYCAN_ STRUCTURES_BIOSYNTHESIS_ 2	Genes involved in glycan structures - biosynthesis 2	60	B4GALT3(1), FUT6(2), PIGG(2), PIGO(2), PIGQ(1), ST3GAL4(1), UGCG(1)	147244	10	10	10	5	2	3	1	2	2	0.31	0.71
268	HSA00521_STREPTOMYCIN_ BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	10	HK1(3), PGM1(1)	85505	4	4	4	1	4	0	0	0	0	0.31	0.71
269	STREPTOMYCIN_BIOSYNTHESIS		8	HK1(3), PGM1(1)	85505	4	4	4	1	4	0	0	0	0	0.31	0.71
270	HSA00562_INOSITOL_ PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	47	INPP5B(2), PI4KA(3), PIP5K1C(1), PLCB1(6), PLCB4(3), PLCE1(6), SYNJ2(1)	250659	22	18	22	5	5	14	1	2	0	0.31	0.72
271	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	32	APC(7), BMPR1A(2), DVL1(1)	119877	10	10	10	0	2	4	1	2	1	0.32	0.72
272	HSA04660_T_CELL_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in T cell receptor signaling pathway	93	CD3E(1), CDK4(1), GRAP2(1), IL4(1), KRAS(2), MAP3K14(1), NFAT5(1), PAK1(1), PIK3R5(4), PPP3CC(1), PTPRC(4), SOS1(3), VAV1(5)	324271	26	25	26	7	6	11	2	3	4	0.32	0.72
273	HSA00512_O_GLYCAN_ BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	30	B4GALT5(1), GALNT2(2), GALNT6(3), GALNT7(2), GALNT8(1), GALNTL1(2), OGT(2)	156141	13	13	13	3	1	11	0	0	1	0.33	0.73
274	CHONDROITIN		8	XYLT2(1)	10142	1	1	1	0	1	0	0	0	0	0.33	0.73
275	HEPARAN_SULFATE_ BIOSYNTHESIS		8	XYLT2(1)	10142	1	1	1	0	1	0	0	0	0	0.33	0.73
276	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	33	EGFR(2), MAP3K1(4), MAPK1(1), MAPK3(1), PAK1(1), PRKCA(3), PTK2(2), RAF1(1), SOS1(3)	185598	18	17	18	5	6	9	0	1	2	0.33	0.73
277	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	7	CDC25B(2)	26740	2	2	2	1	0	1	1	0	0	0.33	0.74
278	HSA00052_GALACTOSE_ METABOLISM	Genes involved in galactose metabolism	32	GALT(1), HK1(3), MGAM(7), PFKP(2), PGM1(1)	158349	14	12	14	5	5	7	0	1	1	0.33	0.74
279	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	12	GNAS(2), PLCE1(6)	83615	8	8	8	3	1	6	0	1	0	0.34	0.74
280	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	6	LDLR(3)	38263	3	3	3	0	1	1	0	1	0	0.35	0.78
281	HSA00600_SPHINGOLIPID_ METABOLISM	Genes involved in sphingolipid metabolism	36	ARSE(2), NEU1(2), SMPD2(3), SMPD3(2), UGCG(1)	181332	10	8	10	0	6	2	1	1	0	0.36	0.80
282	ST_FAS_SIGNALING_ PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	59	BAK1(1), BTK(2), CAD(2), CASP10(2), EGFR(2), EPHB2(3), FAIM2(1), MAP3K1(4), MAPK1(1), MAPK8IP1(4), MAPK8IP3(3), MET(2), NFAT5(1), NFKBIL2(5), PTPN13(2), RALBP1(1)	439439	36	27	36	6	11	16	2	4	3	0.37	0.80
283	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	26	EGFR(2), MAP3K1(4), MAPK3(1), PRKCA(3), RAF1(1), RASA1(2), SOS1(3), STAT1(1)	239569	17	17	17	3	4	8	0	1	4	0.37	0.80
284	SIG_REGULATION_OF_ THE_ACTIN_CYTOSKELETON_ BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	35	ACTG2(3), FLNA(4), MYH2(14), MYLK(1), PAK1(1), RHO(1), WASL(1)	290075	25	21	25	6	6	14	0	2	3	0.37	0.80
285	ST_TUMOR_NECROSIS_ FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	28	BAG4(1), CFLAR(1), NFKBIL2(5), RALBP1(1), TNFRSF1A(2), TNFRSF1B(1)	187906	11	11	11	2	3	3	1	3	1	0.37	0.80
286	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	5	NOTCH1(6)	69622	6	5	6	1	0	5	0	0	1	0.37	0.80
287	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	21	MAPK3(1), RAF1(1), RALBP1(1), RELA(2)	59969	5	4	5	3	2	2	0	1	0	0.37	0.80
288	HSA00360_PHENYLALANINE_ METABOLISM	Genes involved in phenylalanine metabolism	27	ALDH3A1(1), AOC2(1), DDC(3), TAT(3), TPO(5)	143409	13	12	13	7	3	7	1	0	2	0.38	0.80
289	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	39	MAP2K6(2), MAP3K1(4), MAPKAPK5(1), MAX(1), PLA2G4A(4), STAT1(1)	165215	13	13	13	5	3	6	0	1	3	0.38	0.81
290	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	22	CSF2RB(4)	38474	4	4	4	2	2	2	0	0	0	0.38	0.81
291	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	22	EIF4A1(1), EIF4G3(2), MAPK1(1), MAPK3(1), PRKCA(3)	112777	8	8	8	2	0	5	0	1	2	0.38	0.81
292	HSA04060_CYTOKINE_ CYTOKINE_RECEPTOR_ INTERACTION	Genes involved in cytokine-cytokine receptor interaction	252	BMPR1A(2), CSF1R(2), CSF2RB(4), CXCR3(1), EGFR(2), EPOR(1), FLT4(1), IFNA16(2), IL10RA(1), IL11RA(1), IL12RB2(2), IL18RAP(3), IL1B(1), IL21R(2), IL22(1), IL22RA2(1), IL4(1), IL5RA(2), INHBC(1), LEPR(8), MET(2), PDGFRB(5), PLEKHO2(3), TNFRSF1A(2), TNFRSF1B(1), TPO(5)	763845	57	45	57	18	18	25	5	4	5	0.39	0.82
293	HSA04650_NATURAL_ KILLER_CELL_MEDIATED_ CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	126	ARAF(1), BRAF(4), FCGR3A(2), IFNA16(2), ITGAL(2), KLRC3(1), KRAS(2), MAPK1(1), MAPK3(1), NFAT5(1), PAK1(1), PIK3R5(4), PPP3CC(1), PRKCA(3), RAF1(1), SOS1(3), VAV1(5)	449244	35	33	35	11	7	17	2	4	5	0.39	0.82
294	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	22	BTK(2), LYN(1), PFKP(2), PRKCE(2), PRKCZ(1), RAB5A(1)	88235	9	8	9	1	2	6	0	0	1	0.40	0.83
295	HSA00330_ARGININE_ AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	34	CPS1(9), NOS3(1)	104376	10	9	10	2	3	6	0	0	1	0.40	0.83
296	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	6	GNAS(2)	16178	2	2	2	2	0	2	0	0	0	0.40	0.83
297	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	25	ATM(4), CDK4(1)	56264	5	5	5	0	2	2	0	1	0	0.40	0.83
298	HSA00430_TAURINE_ AND_HYPOTAURINE_ METABOLISM	Genes involved in taurine and hypotaurine metabolism	6	CSAD(1)	13358	1	1	1	0	1	0	0	0	0	0.40	0.83
299	GLUTAMATE_METABOLISM		24	CAD(2), CPS1(9)	112678	11	10	11	2	3	7	0	0	1	0.41	0.84
300	HSA00650_BUTANOATE_ METABOLISM	Genes involved in butanoate metabolism	45	AACS(2), ACSM1(3), ALDH3A1(1), HSD17B4(1)	91858	7	7	7	3	1	3	1	1	1	0.41	0.84
301	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	27	CASP10(2), CFLAR(1), DFFB(1), MAP3K1(4), PAK1(1), PRKDC(4), PTPN13(2), SPTAN1(2)	230379	17	15	17	4	6	8	0	0	3	0.41	0.84
302	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	22	CDK4(1), MAPK1(1), MAPK3(1), PAK1(1), RAF1(1), RELA(2)	87189	7	6	7	2	4	3	0	0	0	0.41	0.85
303	HSA00230_PURINE_ METABOLISM	Genes involved in purine metabolism	142	ADA(1), ADCY2(11), ADCY3(3), ADCY4(3), ADCY5(2), ADCY8(8), AK7(1), ENPP3(3), GUCY2C(3), GUCY2D(1), NT5C2(1), NT5C3(2), NT5E(1), PAPSS2(1), PDE10A(4), PDE1A(2), PDE4A(1), PDE4C(1), PDE8A(2), PFAS(5), POLD1(1), POLR2A(2), POLR2F(1), RRM1(1), RRM2B(2)	943978	63	44	62	23	14	32	4	9	4	0.42	0.86
304	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	13	ACTN3(2), PTK2(2), VCL(2)	106692	6	6	6	2	2	2	0	2	0	0.43	0.86
305	HSA04115_P53_SIGNALING_ PATHWAY	Genes involved in p53 signaling pathway	65	ATM(4), BAI1(5), CDK4(1), DDB2(1), RRM2B(2), TSC2(2)	166324	15	12	15	2	3	8	1	2	1	0.43	0.86
306	ATP_SYNTHESIS		21	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	166301	7	6	7	0	2	2	0	0	3	0.43	0.86
307	FLAGELLAR_ASSEMBLY		21	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	166301	7	6	7	0	2	2	0	0	3	0.43	0.86
308	PHOTOSYNTHESIS		22	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	166301	7	6	7	0	2	2	0	0	3	0.43	0.86
309	TYPE_III_SECRETION_ SYSTEM		21	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1)	166301	7	6	7	0	2	2	0	0	3	0.43	0.86
310	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	25	MAP2K6(2), MAP3K1(4), MAP3K14(1), RELA(2), TNFRSF1A(2)	186672	11	10	11	6	4	4	0	0	3	0.43	0.86
311	GLYOXYLATE_AND_DICARBOXYLATE_ METABOLISM		12	ACO1(1), GRHPR(1), MTHFD1L(1)	60672	3	3	3	0	2	0	0	1	0	0.43	0.86
312	HSA00750_VITAMIN_ B6_METABOLISM	Genes involved in vitamin B6 metabolism	5	PDXK(1)	15525	1	1	1	1	1	0	0	0	0	0.45	0.89
313	HSA00630_GLYOXYLATE_ AND_DICARBOXYLATE_ METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	13	ACO1(1), GRHPR(1), MTHFD1L(1)	63326	3	3	3	0	2	0	0	1	0	0.45	0.89
314	GLYCOSPHINGOLIPID_ METABOLISM		23	ARSE(2), NEU1(2), SMPD2(3), UGCG(1)	165743	8	6	8	0	5	1	1	1	0	0.45	0.89
315	BENZOATE_DEGRADATION_ VIA_COA_LIGATION		10	GCDH(1)	37433	1	1	1	2	0	0	1	0	0	0.45	0.89
316	SA_REG_CASCADE_OF_ CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	13	CDK4(1)	14436	1	1	1	0	1	0	0	0	0	0.46	0.90
317	HSA00770_PANTOTHENATE_ AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	16	BCAT2(2), DPYS(2), ENPP3(3), PANK3(1), PANK4(2)	138477	10	9	10	0	3	5	0	2	0	0.47	0.91
318	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	15	MAPK1(1), MAPK3(1), RAF1(1), SOS1(3)	63146	6	6	6	1	1	5	0	0	0	0.47	0.91
319	PENTOSE_AND_GLUCURONATE_ INTERCONVERSIONS		18	UGT1A7(1), UGT2B15(2)	52538	3	3	3	0	1	1	1	0	0	0.47	0.91
320	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	11	CD3E(1), ITGAL(2), PTPRC(4)	80883	7	7	7	4	2	4	1	0	0	0.47	0.91
321	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	11	CD3E(1), ITGAL(2), PTPRC(4)	80883	7	7	7	4	2	4	1	0	0	0.47	0.91
322	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	17	MAPK1(1), MAPK3(1), NTRK1(5)	92976	7	7	7	1	0	5	0	1	1	0.48	0.91
323	HSA04612_ANTIGEN_ PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	73	IFNA16(2), KLRC3(1), LGMN(1), TAPBP(2)	251611	6	6	6	0	0	2	3	0	1	0.48	0.91
324	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	21	EIF4A1(1), EIF4B(2), EIF4G3(2), TSC2(2)	99694	7	7	7	2	1	4	0	0	2	0.49	0.93
325	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	9	MAP3K14(1), RELA(2)	45442	3	2	3	3	1	1	0	0	1	0.50	0.94
326	HSA00530_AMINOSUGARS_ METABOLISM	Genes involved in aminosugars metabolism	29	AMDHD2(1), CHIA(3), CHIT1(3), GFPT2(2), GNE(1), HK1(3)	193616	13	11	13	7	6	6	0	0	1	0.50	0.95
327	HSA00903_LIMONENE_ AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	26	ALDH3A1(1), CYP2C19(6)	105065	7	7	7	7	2	3	0	0	2	0.50	0.95
328	TYROSINE_METABOLISM		32	ADH6(1), ALDH3A1(1), AOC2(1), DDC(3), TAT(3), TPO(5)	167633	14	13	14	4	3	8	1	0	2	0.50	0.95
329	GANGLIOSIDE_BIOSYNTHESIS		8	ST3GAL4(1)	10400	1	1	1	1	0	1	0	0	0	0.51	0.95
330	HSA00260_GLYCINE_ SERINE_AND_THREONINE_ METABOLISM	Genes involved in glycine, serine and threonine metabolism	45	AGXT2(3), AOC2(1), DLD(1), GLDC(3), SARDH(3), SARS2(1)	241655	12	12	12	4	3	6	3	0	0	0.51	0.95
331	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	9	CDC25B(2)	42795	2	2	2	1	0	1	1	0	0	0.51	0.95
332	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	10	BAG4(1), TNFRSF1A(2), TNFRSF1B(1)	79887	4	4	4	0	1	1	0	1	1	0.52	0.96
333	WNT_SIGNALING	Wnt signaling genes	59	APC(7), DVL1(1), DVL3(1), FZD2(2), LDLR(3), PPP2R5C(2), PRKCA(3), PRKCE(2), PRKCZ(1), WNT7A(2)	305380	24	19	24	4	6	12	1	3	2	0.52	0.97
334	HSA04910_INSULIN_ SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	131	ACACA(2), ACACB(6), ARAF(1), BRAF(4), GYS1(1), GYS2(2), INPP5D(4), INSR(2), IRS4(3), KRAS(2), MAPK1(1), MAPK3(1), MKNK2(1), PFKP(2), PHKG1(1), PHKG2(1), PIK3R5(4), PRKAG2(2), PRKCZ(1), PTPRF(4), RAF1(1), RAPGEF1(2), SLC2A4(1), SORBS1(4), SOS1(3), TRIP10(1), TSC2(2)	837668	59	45	59	24	12	37	0	5	5	0.53	0.98
335	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	17	GNAS(2), NOS3(1), RELA(2)	56669	5	4	5	4	1	4	0	0	0	0.54	0.98
336	CELL_CYCLE_KEGG		82	ATM(4), CDC25B(2), CDH1(1), CDK4(1), EP300(4), HDAC2(1), ORC3L(1), PRKDC(4), RBL1(4), TBC1D8(2)	325441	24	21	24	10	4	13	3	2	2	0.54	0.98
337	SIG_IL4RECEPTOR_ IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	27	MAPK1(1), MAPK3(1), RAF1(1), SOS1(3)	66840	6	6	6	1	1	5	0	0	0	0.54	0.98
338	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	16	MAPK1(1), MAPK3(1), PTK2(2), SOS1(3)	80309	7	7	7	1	1	6	0	0	0	0.54	0.98
339	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	12	APC(7), DVL1(1), NOTCH1(6)	181534	14	13	14	1	1	9	1	1	2	0.54	0.98
340	PENTOSE_PHOSPHATE_ PATHWAY		23	GPI(3), PFKP(2), PGM1(1), RBKS(1)	110501	7	6	7	0	2	3	0	0	2	0.55	0.99
341	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	12	F13A1(1), FGG(1)	42266	2	2	2	1	0	1	0	0	1	0.55	0.99
342	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	10	DFFB(1), HMGB1(1), TOP2A(2), TOP2B(2)	76164	6	6	6	2	1	4	0	1	0	0.56	0.99
343	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	15	CDK4(1)	18622	1	1	1	0	1	0	0	0	0	0.56	0.99
344	HSA00220_UREA_CYCLE_ AND_METABOLISM_OF_ AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	30	ALDH3A1(1), AOC2(1), CPS1(9), SMS(2)	161956	13	12	13	4	3	7	1	0	2	0.56	0.99
345	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	10	EGFR(2), MAP3K1(4), NCOR2(3)	141099	9	9	9	3	5	3	0	0	1	0.56	0.99
346	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	20	MAPK3(1), RAF1(1), RASA1(2), SOS1(3)	110028	7	7	7	1	1	4	0	0	2	0.56	0.99
347	HSA00040_PENTOSE_ AND_GLUCURONATE_ INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	25	UGT1A7(1), UGT2B15(2)	60362	3	3	3	0	1	1	1	0	0	0.56	0.99
348	GAMMA_HEXACHLOROCYCLOHEXANE_ DEGRADATION		31	ACPP(1), ALPP(2), CYP19A1(3), CYP2B6(1), CYP2C19(6), CYP2F1(1), CYP4F8(2)	204363	16	14	16	9	5	10	0	0	1	0.56	0.99
349	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	19	EPOR(1), JAK2(3), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	145153	10	10	10	1	1	6	0	1	2	0.56	0.99
350	HSA00730_THIAMINE_ METABOLISM	Genes involved in thiamine metabolism	8	NFS1(1)	11610	1	1	1	1	0	1	0	0	0	0.56	0.99
351	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	6	CFLAR(1)	11610	1	1	1	0	0	1	0	0	0	0.57	1.00
352	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	22	CDK4(1), RBL1(4)	89470	5	5	5	0	1	2	1	0	1	0.58	1.00
353	HSA00252_ALANINE_ AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	33	AARS2(4), AGXT2(3), CAD(2), CRAT(1), DLAT(2), DLD(1), NARS2(3), PC(1)	273237	17	14	17	3	3	9	3	1	1	0.58	1.00
354	LIMONENE_AND_PINENE_ DEGRADATION		12	ALDH3A1(1)	37815	1	1	1	2	0	0	0	0	1	0.58	1.00
355	BUTANOATE_METABOLISM		27	AACS(2), ALDH3A1(1)	45478	3	3	3	3	0	2	0	0	1	0.59	1.00
356	HSA00450_SELENOAMINO_ ACID_METABOLISM	Genes involved in selenoamino acid metabolism	26	MARS(1), MAT1A(1), PAPSS2(1), SCLY(1), WBSCR22(1)	86532	5	4	5	2	2	2	0	1	0	0.59	1.00
357	HSA03022_BASAL_TRANSCRIPTION_ FACTORS	Genes involved in basal transcription factors	33	GTF2H1(1), GTF2IRD1(2), TAF1(7), TAF2(3)	260875	13	13	13	1	2	5	1	2	3	0.59	1.00
358	APOPTOSIS		68	BAK1(1), CASP10(2), DFFB(1), HELLS(1), IRF2(1), MAP3K1(4), RELA(2), TNFRSF1A(2), TNFRSF1B(1)	214440	15	12	15	5	6	7	0	1	1	0.59	1.00
359	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	4	BMPR1A(2)	59383	2	2	2	1	1	0	0	1	0	0.59	1.00
360	STEROID_BIOSYNTHESIS		9	HSD17B4(1)	20128	1	1	1	0	1	0	0	0	0	0.59	1.00
361	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	14	DYRK1A(3)	36554	3	3	3	2	0	3	0	0	0	0.60	1.00
362	PROSTAGLANDIN_SYNTHESIS_ REGULATION		29	ANXA5(2), PLA2G4A(4)	93707	6	6	6	3	1	3	0	1	1	0.60	1.00
363	ALKALOID_BIOSYNTHESIS_ II		5	AOC2(1)	64563	1	1	1	2	0	0	1	0	0	0.60	1.00
364	HSA04140_REGULATION_ OF_AUTOPHAGY	Genes involved in regulation of autophagy	29	IFNA16(2), ULK2(1)	75466	3	3	3	0	1	1	1	0	0	0.60	1.00
365	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	7	CREM(1), GNAS(2)	33851	3	3	3	2	1	2	0	0	0	0.61	1.00
366	HSA00480_GLUTATHIONE_ METABOLISM	Genes involved in glutathione metabolism	37	GSR(2)	124672	2	2	2	1	0	0	0	2	0	0.62	1.00
367	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	15	EGFR(2), POLR2A(2), PRKCA(3)	156794	7	7	7	4	1	3	0	2	1	0.62	1.00
368	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	12	MAPK1(1), MAPK3(1), RAF1(1)	34581	3	3	3	1	1	2	0	0	0	0.62	1.00
369	HSA04130_SNARE_INTERACTIONS_ IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	35	BNIP1(1), STX5(1)	58901	2	2	2	0	1	0	0	1	0	0.62	1.00
370	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	85	BRAF(4), MAP2K5(1), MAP2K6(2), MAP3K1(4), MAP3K11(1), MAP3K12(1), MAP3K14(1), MAP4K3(1), MAPK1(1), MAPK3(1), MAPKAPK5(1), MAX(1), MKNK2(1), PAK1(1), RAF1(1), RELA(2), RPS6KA2(2), RPS6KA4(2), STAT1(1)	562162	29	21	29	12	6	16	0	1	6	0.63	1.00
371	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	18	MAPK3(1), RAF1(1), SOS1(3)	56510	5	5	5	1	1	4	0	0	0	0.64	1.00
372	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	21	CD5(1), IL4(1), TLR9(1)	39715	3	3	3	2	0	3	0	0	0	0.64	1.00
373	HSA00280_VALINE_ LEUCINE_AND_ISOLEUCINE_ DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	44	ALDH3A1(1), BCAT2(2), DBT(1), DLD(1), HSD17B4(1)	143986	6	6	6	4	3	1	0	0	2	0.64	1.00
374	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	8	ATM(4), CDC25B(2)	102580	6	6	6	1	1	3	1	1	0	0.65	1.00
375	HISTIDINE_METABOLISM		24	ALDH3A1(1), AOC2(1), DDC(3)	99457	5	5	5	2	1	2	1	0	1	0.65	1.00
376	HSA00251_GLUTAMATE_ METABOLISM	Genes involved in glutamate metabolism	31	CAD(2), CPS1(9), GFPT2(2), GSR(2)	216052	15	13	15	3	3	8	0	2	2	0.66	1.00
377	HSA00030_PENTOSE_ PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	26	GPI(3), PFKP(2), PGM1(1), RBKS(1)	130054	7	6	7	1	2	3	0	0	2	0.66	1.00
378	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	10	CD3E(1), ITGAL(2)	38115	3	3	3	2	1	2	0	0	0	0.66	1.00
379	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	7	CHRM1(1), PLCB1(6)	122952	7	6	7	2	3	3	0	1	0	0.67	1.00
380	HSA00440_AMINOPHOSPHONATE_ METABOLISM	Genes involved in aminophosphonate metabolism	16	WBSCR22(1)	30916	1	1	1	1	1	0	0	0	0	0.67	1.00
381	ST_WNT_BETA_CATENIN_ PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	31	ANKRD6(3), APC(7), DVL1(1), FSTL1(1), LRP1(8), MVP(1), SENP2(1)	319998	22	19	20	3	3	15	2	1	1	0.67	1.00
382	HSA05120_EPITHELIAL_ CELL_SIGNALING_IN_ HELICOBACTER_PYLORI_ INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	66	ATP6V0A1(3), ATP6V0A2(5), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1), EGFR(2), LYN(1), MAP3K14(1), MET(2), PAK1(1), RELA(2)	360966	21	17	21	6	7	8	1	1	4	0.67	1.00
383	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	28	BAG4(1), DFFB(1), MADD(2), MAP3K1(4), PAK1(1), PRKDC(4), SPTAN1(2), TNFRSF1A(2)	303523	17	16	17	5	7	7	0	0	3	0.67	1.00
384	HSA00051_FRUCTOSE_ AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	40	GMPPA(1), HK1(3), PFKP(2)	152373	6	5	6	0	4	2	0	0	0	0.68	1.00
385	HSA04120_UBIQUITIN_ MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	39	ANAPC4(2), CUL2(2), SMURF2(1), UBA1(1)	116083	6	6	6	1	0	4	1	0	1	0.68	1.00
386	HSA00641_3_CHLOROACRYLIC_ ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	15	ADH6(1), ALDH3A1(1)	59986	2	2	2	0	0	1	0	0	1	0.68	1.00
387	HSA00564_GLYCEROPHOSPHOLIPID_ METABOLISM	Genes involved in glycerophospholipid metabolism	64	AGPAT4(1), CRLS1(1), GPAM(4), PLA2G4A(4)	171416	10	10	10	10	2	4	1	1	2	0.69	1.00
388	O_GLYCAN_BIOSYNTHESIS		14	GALNT2(2), GALNT6(3), GALNT7(2), GALNT8(1), ST3GAL4(1)	121550	9	9	9	2	1	7	0	0	1	0.69	1.00
389	HSA04614_RENIN_ANGIOTENSIN_ SYSTEM	Genes involved in renin-angiotensin system	17	ACE2(2), CMA1(1), CTSA(1), CTSG(2), THOP1(1)	90353	7	7	7	2	2	5	0	0	0	0.70	1.00
390	SMALL_LIGAND_GPCRS		14	DNMT1(3), TBXA2R(1)	61959	4	4	4	1	0	4	0	0	0	0.70	1.00
391	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	12	ATM(4), CDC25B(2), CDK4(1)	117017	7	7	7	1	2	3	1	1	0	0.70	1.00
392	HSA00590_ARACHIDONIC_ ACID_METABOLISM	Genes involved in arachidonic acid metabolism	51	ALOX12B(1), CYP2B6(1), CYP2C19(6), PLA2G4A(4)	152456	12	10	12	6	3	7	0	1	1	0.71	1.00
393	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	7	EGFR(2), RAB5A(1)	41225	3	3	3	1	1	2	0	0	0	0.71	1.00
394	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	12	CASP10(2)	27270	2	2	2	1	0	2	0	0	0	0.71	1.00
395	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	21	JAK2(3), MAPK3(1), RAF1(1), SOS1(3)	120867	8	8	8	1	1	5	0	1	1	0.72	1.00
396	CITRATE_CYCLE_TCA_ CYCLE		20	ACO1(1), DLD(1), DLST(1), IDH3A(1), IDH3B(1), PC(1)	123154	6	6	6	0	3	2	0	1	0	0.72	1.00
397	STATIN_PATHWAY_PHARMGKB		18	LDLR(3), LRP1(8)	151522	11	10	9	2	2	7	1	1	0	0.72	1.00
398	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	14	PAK1(1), WASL(1)	35640	2	2	2	0	1	1	0	0	0	0.73	1.00
399	REDUCTIVE_CARBOXYLATE_ CYCLE_CO2_FIXATION		9	ACO1(1)	34692	1	1	1	0	1	0	0	0	0	0.73	1.00
400	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	25	EIF2B1(1), EIF2B3(1), EIF2B4(1), FLT4(1), NOS3(1), PRKCA(3), PTK2(2)	175316	10	9	10	6	1	6	0	1	2	0.74	1.00
401	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	5	EGFR(2), ERBB3(2)	66028	4	3	4	1	1	2	0	0	1	0.74	1.00
402	VALINE_LEUCINE_AND_ ISOLEUCINE_BIOSYNTHESIS		7	LARS(1), LARS2(2)	48873	3	3	3	0	0	3	0	0	0	0.75	1.00
403	HSA01030_GLYCAN_ STRUCTURES_BIOSYNTHESIS_ 1	Genes involved in glycan structures - biosynthesis 1	109	B4GALT3(1), B4GALT5(1), CHPF(1), EXT2(1), EXTL1(1), GALNT2(2), GALNT6(3), GALNT7(2), GALNT8(1), GALNTL1(2), GANAB(4), MAN1A1(3), MAN2A1(4), NDST1(3), NDST2(3), OGT(2), ST3GAL4(1), XYLT2(1)	547464	36	33	36	11	7	24	0	2	3	0.75	1.00
404	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	19	BAK1(1), DFFB(1)	39039	2	2	2	0	1	1	0	0	0	0.76	1.00
405	HSA04620_TOLL_LIKE_ RECEPTOR_SIGNALING_ PATHWAY	Genes involved in Toll-like receptor signaling pathway	100	IFNA16(2), IL1B(1), IRAK1(4), MAP2K6(2), MAPK1(1), MAPK3(1), MYD88(1), PIK3R5(4), RELA(2), STAT1(1), TLR9(1), TOLLIP(1)	297494	21	19	21	9	6	10	2	1	2	0.76	1.00
406	HSA00740_RIBOFLAVIN_ METABOLISM	Genes involved in riboflavin metabolism	16	ACP6(1), ACPP(1), ENPP3(3)	66513	5	5	5	0	2	3	0	0	0	0.76	1.00
407	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	16	MAPK1(1), MAPK3(1), SOS1(3)	79795	5	5	5	1	0	5	0	0	0	0.76	1.00
408	HSA00960_ALKALOID_ BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	18	AOC2(1)	93844	1	1	1	5	0	0	1	0	0	0.77	1.00
409	HSA00620_PYRUVATE_ METABOLISM	Genes involved in pyruvate metabolism	42	ACACA(2), ACACB(6), ACSS1(2), ALDH3A1(1), DLAT(2), DLD(1), GRHPR(1), LDHB(1), LDHC(1), PC(1)	231214	18	16	18	4	5	10	1	1	1	0.77	1.00
410	FRUCTOSE_AND_MANNOSE_ METABOLISM		25	GMPPA(1), HK1(3), PFKP(2)	177610	6	5	6	1	4	2	0	0	0	0.77	1.00
411	TRYPTOPHAN_METABOLISM		54	ALDH3A1(1), AOC2(1), CYP19A1(3), CYP2B6(1), CYP2C19(6), CYP2F1(1), CYP4F8(2), DDC(3), GCDH(1), WARS(1)	284648	20	16	20	14	5	11	2	0	2	0.77	1.00
412	HSA00410_BETA_ALANINE_ METABOLISM	Genes involved in beta-alanine metabolism	25	ALDH3A1(1), AOC2(1), DPYS(2), SMS(2)	131399	6	5	6	4	1	3	1	0	1	0.77	1.00
413	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	43	DLAT(2), DLD(1), GPI(3), HK1(3), LDHB(1), LDHC(1), PC(1), PFKP(2), PGK1(2)	263510	16	14	16	1	6	8	1	0	1	0.77	1.00
414	HSA00190_OXIDATIVE_ PHOSPHORYLATION	Genes involved in oxidative phosphorylation	113	ATP4A(2), ATP6V0A1(3), ATP6V0A2(5), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1), CYC1(2)	413775	16	14	16	6	4	8	0	0	4	0.78	1.00
415	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	15	CASP10(2), DFFB(1)	52440	3	3	3	1	0	3	0	0	0	0.78	1.00
416	PHENYLALANINE_TYROSINE_ AND_TRYPTOPHAN_BIOSYNTHESIS		9	PAH(2), TAT(3)	95872	5	5	5	1	3	2	0	0	0	0.78	1.00
417	HSA00380_TRYPTOPHAN_ METABOLISM	Genes involved in tryptophan metabolism	58	ALDH3A1(1), AOC2(1), DDC(3), GCDH(1), HSD17B4(1), WARS(1), WBSCR22(1)	240108	9	9	9	8	4	2	2	0	1	0.78	1.00
418	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	13	PTK2(2)	31172	2	2	2	4	1	1	0	0	0	0.78	1.00
419	KREBS_TCA_CYCLE		30	DLAT(2), DLD(1), DLST(1), IDH3A(1), IDH3B(1), PC(1)	145351	7	7	7	2	2	3	1	1	0	0.78	1.00
420	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	18	CSF1R(2), DDX20(1), HDAC2(1), NCOR2(3), RBL1(4)	156588	11	11	11	1	2	6	1	1	1	0.78	1.00
421	PORPHYRIN_AND_CHLOROPHYLL_ METABOLISM		26	CP(1), UGT1A7(1), UGT2B15(2)	112573	4	4	4	1	1	2	1	0	0	0.79	1.00
422	HSA00561_GLYCEROLIPID_ METABOLISM	Genes involved in glycerolipid metabolism	55	ADH6(1), AGPAT4(1), ALDH3A1(1), GPAM(4), LIPF(1), PNLIP(5), PNLIPRP1(3), PNLIPRP2(1)	289522	17	17	17	9	5	7	1	1	3	0.79	1.00
423	ST_TYPE_I_INTERFERON_ PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	8	PTPRU(3), STAT1(1)	61202	4	3	4	2	0	4	0	0	0	0.79	1.00
424	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	25	INSR(2), JAK2(3), MAPK1(1), MAPK3(1), PRKCA(3), RAF1(1), SLC2A4(1), SOS1(3), STAT5B(1)	339345	16	16	16	1	1	10	0	3	2	0.79	1.00
425	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	18	NTRK1(5), WASF3(1), WASL(1)	125978	7	7	7	1	0	5	0	1	1	0.79	1.00
426	IRINOTECAN_PATHWAY_ PHARMGKB		17	ABCC1(4), ABCC2(2), UGT1A7(1)	102004	7	7	7	1	3	4	0	0	0	0.79	1.00
427	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	22	MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	83668	6	6	6	1	1	5	0	0	0	0.79	1.00
428	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	11	IL4(1)	22279	1	1	1	0	0	1	0	0	0	0.80	1.00
429	BILE_ACID_BIOSYNTHESIS		27	ADH6(1), ALDH3A1(1)	75508	2	2	2	0	0	1	0	0	1	0.80	1.00
430	HSA00920_SULFUR_ METABOLISM	Genes involved in sulfur metabolism	14	PAPSS2(1)	41953	1	1	1	0	1	0	0	0	0	0.80	1.00
431	SULFUR_METABOLISM		9	PAPSS2(1)	41953	1	1	1	0	1	0	0	0	0	0.80	1.00
432	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	22	CAP1(1), GNAS(2), MAPK1(1), MAPK3(1)	102882	5	5	5	2	0	4	0	1	0	0.80	1.00
433	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	14	RELA(2)	34331	2	1	2	2	1	1	0	0	0	0.80	1.00
434	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	35	CREB3(1), MAP2K6(2), MAPK1(1), MAPKAPK5(1), MKNK2(1)	197538	6	6	6	2	0	4	0	0	2	0.81	1.00
435	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	8	ITGAL(2), ITGAM(2), SELL(1)	73305	5	5	5	5	2	3	0	0	0	0.81	1.00
436	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	14	CAMK2A(2), CAMK2D(1), CAMK4(1), CAMKK1(2)	150511	6	6	6	4	3	2	1	0	0	0.81	1.00
437	NUCLEAR_RECEPTORS		40	ALK(6), NR0B1(1)	203944	7	7	7	2	2	3	2	0	0	0.81	1.00
438	HSA00640_PROPANOATE_ METABOLISM	Genes involved in propanoate metabolism	33	ACACA(2), ACACB(6), ACSS1(2), ALDH3A1(1), LDHB(1), LDHC(1)	167186	13	12	13	6	3	8	0	1	1	0.81	1.00
439	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	15	MAP3K14(1), RELA(2)	77690	3	2	3	3	1	1	0	0	1	0.82	1.00
440	MRNA_PROCESSING_ REACTOME		92	CLK2(1), CLK3(1), DDX20(1), DHX8(1), NXF1(1), POLR2A(2), PRPF3(3), PRPF8(1), SF3A2(1), SFRS4(1), SFRS8(6), SRPK1(2), SRRM1(1), SUPT5H(1)	523489	23	20	23	7	5	10	2	4	2	0.82	1.00
441	ACE_INHIBITOR_PATHWAY_ PHARMGKB		8	NOS3(1)	27524	1	1	1	1	0	1	0	0	0	0.84	1.00
442	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	34	CFLAR(1), MAPK1(1), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	145668	8	8	8	1	1	7	0	0	0	0.84	1.00
443	OXIDATIVE_PHOSPHORYLATION		60	ATP6V0A1(3), ATP6V1B1(2), ATP6V1G3(1), ATP6V1H(1), ATP7A(5)	313664	12	11	12	2	3	5	1	0	3	0.84	1.00
444	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	48	ADCY4(3), ADCY8(8), CACNA1A(6), GNAS(2), ITPR3(3), PDE1A(2)	351707	24	19	24	7	7	12	1	2	2	0.84	1.00
445	GLYCEROPHOSPHOLIPID_ METABOLISM		49	AGPAT4(1), PLA2G4A(4)	125346	5	5	5	4	1	2	0	1	1	0.84	1.00
446	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	15	INSR(2), MAGI1(3)	113829	5	5	5	1	2	2	0	1	0	0.85	1.00
447	HSA00720_REDUCTIVE_ CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	11	ACLY(1), ACO1(1), ACSS1(2)	115416	4	4	4	1	2	1	0	1	0	0.85	1.00
448	HSA00626_NAPHTHALENE_ AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	18	WBSCR22(1)	49207	1	1	1	1	1	0	0	0	0	0.85	1.00
449	DNA_REPLICATION_ REACTOME		42	MCM10(1), ORC3L(1), POLD1(1), RPA1(1)	122100	4	4	4	8	1	2	1	0	0	0.85	1.00
450	BETA_ALANINE_METABOLISM		27	ALDH3A1(1), AOC2(1), DPYS(2), SMS(2)	158534	6	5	6	5	1	3	1	0	1	0.85	1.00
451	VALINE_LEUCINE_AND_ ISOLEUCINE_DEGRADATION		36	ALDH3A1(1)	92158	1	1	1	3	0	0	0	0	1	0.86	1.00
452	HSA00970_AMINOACYL_ TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	38	AARS2(4), CARS(3), LARS(1), LARS2(2), MARS(1), NARS2(3), SARS2(1), VARS(3), WARS(1)	441020	19	13	19	6	2	9	3	2	3	0.86	1.00
453	GLYCOSAMINOGLYCAN_ DEGRADATION		11	NAGLU(1)	96394	1	1	1	0	0	0	0	1	0	0.86	1.00
454	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	20	ATM(4), PRKCA(3), PTK2(2), STAT1(1), TLN1(3)	256285	13	11	13	2	3	6	1	2	1	0.86	1.00
455	HSA00350_TYROSINE_ METABOLISM	Genes involved in tyrosine metabolism	56	ADH6(1), ALDH3A1(1), AOC2(1), DDC(3), TAT(3), TPO(5), WBSCR22(1)	232638	15	14	15	8	4	8	1	0	2	0.86	1.00
456	GLYCEROLIPID_METABOLISM		45	ADH6(1), AGPAT4(1), ALDH3A1(1), LIPF(1), PNLIP(5), PNLIPRP1(3), PNLIPRP2(1)	256835	13	13	13	6	5	5	0	1	2	0.86	1.00
457	AMINOACYL_TRNA_BIOSYNTHESIS		21	CARS(3), LARS(1), LARS2(2), MARS(1), WARS(1)	173230	8	8	8	3	1	4	1	1	1	0.87	1.00
458	FOLATE_BIOSYNTHESIS		9	ALPP(2)	39474	2	2	2	0	1	1	0	0	0	0.87	1.00
459	CARBON_FIXATION		21	PGK1(2)	50499	2	2	2	0	1	1	0	0	0	0.87	1.00
460	AMINOSUGARS_METABOLISM		15	GNE(1), HK1(3)	165454	4	3	4	5	3	1	0	0	0	0.88	1.00
461	HSA00120_BILE_ACID_ BIOSYNTHESIS	Genes involved in bile acid biosynthesis	38	ADH6(1), ALDH3A1(1)	97166	2	2	2	0	0	1	0	0	1	0.88	1.00
462	HSA03050_PROTEASOME	Genes involved in proteasome	22	PSMB3(1), PSMC3(1), PSMD1(1), PSMD13(1)	140394	4	4	4	3	1	1	0	1	1	0.88	1.00
463	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	20	PSMB3(1), PSMC3(1)	115152	2	2	2	2	0	1	0	1	0	0.88	1.00
464	HSA00500_STARCH_ AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	83	AGL(2), DDX19A(2), DDX4(2), DDX54(2), ENPP3(3), ERCC2(1), GPI(3), GYS1(1), GYS2(2), HK1(3), MGAM(7), PGM1(1), SETX(2), SKIV2L2(3), SMARCA2(4), UGT1A7(1), UGT2B15(2)	592755	41	31	41	18	12	21	2	2	4	0.89	1.00
465	HSA00632_BENZOATE_ DEGRADATION_VIA_ COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	24	GCDH(1)	112053	1	1	1	5	0	0	1	0	0	0.89	1.00
466	HSA00071_FATTY_ACID_ METABOLISM	Genes involved in fatty acid metabolism	47	ACSL3(1), ADH6(1), ALDH3A1(1), GCDH(1), HSD17B4(1)	190998	5	5	5	3	1	2	1	0	1	0.90	1.00
467	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	12	RELA(2)	56843	2	1	2	2	1	1	0	0	0	0.90	1.00
468	HSA00010_GLYCOLYSIS_ AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	64	ACSS1(2), ADH6(1), ALDH3A1(1), DLAT(2), DLD(1), GPI(3), HK1(3), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PGM1(1)	421042	20	16	20	2	8	8	1	1	2	0.90	1.00
469	GLUCONEOGENESIS		53	ADH6(1), ALDH3A1(1), DLAT(2), DLD(1), GPI(3), HK1(3), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PGM1(1)	353919	18	14	18	1	7	8	1	0	2	0.90	1.00
470	GLYCOLYSIS		53	ADH6(1), ALDH3A1(1), DLAT(2), DLD(1), GPI(3), HK1(3), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PGM1(1)	353919	18	14	18	1	7	8	1	0	2	0.90	1.00
471	HSA00860_PORPHYRIN_ AND_CHLOROPHYLL_ METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	41	CP(1), UGT1A7(1), UGT2B15(2)	177047	4	4	4	1	1	2	1	0	0	0.91	1.00
472	PYRUVATE_METABOLISM		37	ACACA(2), ALDH3A1(1), DLAT(2), DLD(1), GRHPR(1), LDHB(1), LDHC(1), PC(1)	165830	10	9	10	2	2	6	1	0	1	0.91	1.00
473	HSA00062_FATTY_ACID_ ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	10	HSD17B4(1)	46606	1	1	1	0	1	0	0	0	0	0.91	1.00
474	SIG_INSULIN_RECEPTOR_ PATHWAY_IN_CARDIAC_ MYOCYTES	Genes related to the insulin receptor pathway	49	BRD4(2), CAP1(1), IRS4(3), MAPK1(1), MAPK3(1), PARD3(3), RAF1(1), RPS6KA2(2), SERPINB6(2), SLC2A4(1), SORBS1(4), SOS1(3)	364791	24	19	24	5	6	14	1	2	1	0.91	1.00
475	PROTEASOME		17	PSMB3(1), PSMB8(1)	131622	2	2	2	1	0	1	0	1	0	0.91	1.00
476	HSA00340_HISTIDINE_ METABOLISM	Genes involved in histidine metabolism	41	ALDH3A1(1), AOC2(1), DDC(3), WBSCR22(1)	158435	6	6	6	4	2	2	1	0	1	0.91	1.00
477	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	13	CREM(1), MAPK3(1), POLR2A(2)	131919	4	4	4	1	1	2	0	1	0	0.91	1.00
478	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	13	IL10RA(1), STAT1(1)	49742	2	2	2	3	0	2	0	0	0	0.91	1.00
479	HSA05130_PATHOGENIC_ ESCHERICHIA_COLI_ INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	51	CDH1(1), OCLN(1), PRKCA(3), TUBB2C(1), TUBB4(3), WASL(1)	180717	10	10	10	2	1	6	1	1	1	0.91	1.00
480	HSA05131_PATHOGENIC_ ESCHERICHIA_COLI_ INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	51	CDH1(1), OCLN(1), PRKCA(3), TUBB2C(1), TUBB4(3), WASL(1)	180717	10	10	10	2	1	6	1	1	1	0.91	1.00
481	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	14	NCOR2(3), POLR2A(2)	131063	5	5	5	2	2	2	0	1	0	0.92	1.00
482	PHOSPHATIDYLINOSITOL_ SIGNALING_SYSTEM		82	ACVRL1(2), BMPR1A(2), CLK2(1), COL4A3BP(3), PIK3C2A(1), PIK3C2B(5), PIK3C2G(1), PLCB1(6), PLCB4(3), PRKCA(3), PRKCE(2), PRKCZ(1), RAF1(1), RPS6KA2(2), RPS6KA4(2)	599354	35	31	35	10	9	17	2	4	3	0.92	1.00
483	N_GLYCAN_BIOSYNTHESIS		21	B4GALT3(1), B4GALT5(1), MAN1A1(3)	138389	5	5	5	2	3	2	0	0	0	0.93	1.00
484	G1_TO_S_CELL_CYCLE_ REACTOME		65	ATM(4), CDK4(1), CREB3(1), ORC3L(1), RBL1(4), RPA1(1), TNXB(12)	460649	24	17	24	9	5	13	3	1	2	0.93	1.00
485	PROPANOATE_METABOLISM		31	ACACA(2), ALDH3A1(1), LDHB(1), LDHC(1)	128937	5	5	5	5	0	4	0	0	1	0.95	1.00
486	HSA00532_CHONDROITIN_ SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	17	CHPF(1), XYLT2(1)	110692	2	2	2	1	1	0	0	1	0	0.95	1.00
487	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	30	INSR(2), MAP2K6(2), PPP3CC(1)	282413	5	5	5	4	0	2	0	1	2	0.96	1.00
488	ACETYLCHOLINE_SYNTHESIS		8		0	0	0	0	0	0	0	0	0	0	1.00	1.00
489	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
490	BLOOD_GROUP_GLYCOLIPID_ BIOSYNTHESIS_NEOLACTOSERIES		7		0	0	0	0	0	0	0	0	0	0	1.00	1.00
491	CYANOAMINO_ACID_ METABOLISM		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
492	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	8		0	0	0	0	0	0	0	0	0	0	1.00	1.00
493	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	15		0	0	0	0	0	0	0	0	0	0	1.00	1.00
494	HSA00031_INOSITOL_ METABOLISM	Genes involved in inositol metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
495	HSA00072_SYNTHESIS_ AND_DEGRADATION_ OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	9		0	0	0	0	0	0	0	0	0	0	1.00	1.00
496	HSA00300_LYSINE_ BIOSYNTHESIS	Genes involved in lysine biosynthesis	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
497	HSA00471_D_GLUTAMINE_ AND_D_GLUTAMATE_ METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
498	HSA00472_D_ARGININE_ AND_D_ORNITHINE_ METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	1		0	0	0	0	0	0	0	0	0	0	1.00	1.00
499	HSA00550_PEPTIDOGLYCAN_ BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
500	HSA00627_1,4_DICHLOROBENZENE_ DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	1		0	0	0	0	0	0	0	0	0	0	1.00	1.00
501	HSA00643_STYRENE_ DEGRADATION	Genes involved in styrene degradation	3		0	0	0	0	0	0	0	0	0	0	1.00	1.00
502	HSA00660_C5_BRANCHED_ DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
503	HSA00780_BIOTIN_ METABOLISM	Genes involved in biotin metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
504	HSA00785_LIPOIC_ ACID_METABOLISM	Genes involved in lipoic acid metabolism	2		0	0	0	0	0	0	0	0	0	0	1.00	1.00
505	HSA00830_RETINOL_ METABOLISM	Genes involved in retinol metabolism	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
506	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
507	INOSITOL_METABOLISM		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
508	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	13		0	0	0	0	0	0	0	0	0	0	1.00	1.00
509	LYSINE_BIOSYNTHESIS		5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
510	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
511	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	10		0	0	0	0	0	0	0	0	0	0	1.00	1.00
512	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
513	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	3		0	0	0	0	0	0	0	0	0	0	1.00	1.00
514	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
515	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	5		0	0	0	0	0	0	0	0	0	0	1.00	1.00
516	ST_PAC1_RECEPTOR_ PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	6		0	0	0	0	0	0	0	0	0	0	1.00	1.00
517	SYNTHESIS_AND_DEGRADATION_ OF_KETONE_BODIES		4		0	0	0	0	0	0	0	0	0	0	1.00	1.00
518	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	7		0	0	0	0	0	0	0	0	0	0	1.00	1.00
519	HSA00790_FOLATE_ BIOSYNTHESIS	Genes involved in folate biosynthesis	41	ALPP(2), DDX19A(2), DDX4(2), DDX54(2), ERCC2(1), SETX(2), SKIV2L2(3), SMARCA2(4)	337460	18	17	18	8	4	12	1	0	1	1.00	1.00
520	SIG_PIP3_SIGNALING_ IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	63	CREB3(1), IFI27(1), IRS4(3), MET(2), PAK1(1), PARD3(3), PTK2(2), RPS6KA2(2), SLC2A4(1), SOS1(3), TSC2(2)	394817	21	19	21	4	6	10	1	2	2	1.00	1.00
521	HSA00510_N_GLYCAN_ BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	41	B4GALT3(1), GANAB(4), MAN1A1(3), MAN2A1(4)	238470	12	11	12	2	4	7	0	0	1	1.00	1.00
522	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	35	ACTN3(2), CAPN1(2), ITGA1(1), MAPK1(1), MAPK3(1), PPP1R12B(1), PTK2(2), RAF1(1), SOS1(3), TLN1(3), VCL(2)	417636	19	19	19	4	6	9	1	2	1	1.00	1.00
523	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	9	ITGAL(2), SELL(1)	66420	3	3	3	3	1	2	0	0	0	1.00	1.00
524	HSA00980_METABOLISM_ OF_XENOBIOTICS_BY_ CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	70	ADH6(1), AKR1C1(1), ALDH3A1(1), CYP2B6(1), CYP2C19(6), CYP2F1(1), UGT1A7(1), UGT2B15(2)	313318	14	11	14	8	3	8	1	0	2	1.00	1.00
525	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	32	CASP10(2), CFLAR(1), DFFB(1), MAP3K14(1), RELA(2), SPTAN1(2)	201584	9	8	9	5	2	6	0	0	1	1.00	1.00
526	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	24	CAPN1(2), CXCR3(1), EGFR(2), ITGA1(1), MAPK1(1), MAPK3(1), MYLK(1), PTK2(2), TLN1(3)	328549	14	14	14	5	5	7	1	0	1	1.00	1.00
527	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	12	ARFGAP1(1), COPA(4), GBF1(4)	218539	9	9	9	0	0	6	1	1	1	1.00	1.00
528	GPCRDB_CLASS_A_RHODOPSIN_ LIKE		164	AVPR2(2), CHRM1(1), CXCR3(1), F2RL3(1), GALT(1), HTR1D(1), NPY1R(3), NTSR2(2), RGR(1), RHO(1), TBXA2R(1)	369060	15	13	15	4	4	10	0	0	1	1.00	1.00
529	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	6	IL1B(1), MST1(4), MST1R(2)	175724	7	7	7	1	1	4	1	1	0	1.00	1.00
530	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	16	ACTN3(2), CAPN1(2), ITGA1(1), PTK2(2), SPTAN1(2), TLN1(3)	313961	12	12	12	4	5	4	1	1	1	1.00	1.00
531	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	7	MAX(1)	27599	1	1	1	0	0	1	0	0	0	1.00	1.00
532	HSA00020_CITRATE_ CYCLE	Genes involved in citrate cycle (TCA cycle)	27	ACLY(1), ACO1(1), DLD(1), DLST(1), IDH3A(1), IDH3B(1), PC(1)	195091	7	7	7	2	3	3	0	1	0	1.00	1.00
533	PYRIMIDINE_METABOLISM		55	CAD(2), DPYS(2), NT5E(1), POLD1(1), POLQ(6), POLR2A(2), POLR2F(1), RRM1(1)	446677	16	15	16	5	3	11	0	2	0	1.00	1.00
534	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	22	ITGA1(1), MAPK1(1), MAPK3(1), MYLK(1), PTK2(2), RAF1(1), TLN1(3)	281433	10	10	10	5	3	5	1	0	1	1.00	1.00
535	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	30	ARHGEF11(7), ARHGEF5(1), MYLK(1), PPP1R12B(1), TLN1(3), VCL(2)	423935	15	14	15	4	5	6	2	1	1	1.00	1.00
536	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_ DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	23	ACP6(1), ACPP(1), ALPP(2)	113356	4	4	4	2	2	2	0	0	0	1.00	1.00
537	HSA00602_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_NEO_ LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	21	B4GALT3(1), FUT6(2)	85807	3	3	3	0	1	2	0	0	0	1.00	1.00
538	HSA03320_PPAR_SIGNALING_ PATHWAY	Genes involved in PPAR signaling pathway	67	ACSL3(1), CD36(1), PLTP(1), SLC27A4(2), SORBS1(4)	261215	9	8	9	10	3	5	1	0	0	1.00	1.00
539	ALANINE_AND_ASPARTATE_ METABOLISM		21	AGXT2(3), CAD(2), CRAT(1), PC(1)	205479	7	7	7	2	1	5	1	0	0	1.00	1.00
540	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	21	INSR(2), MAPK3(1), RAF1(1), RASA1(2), SLC2A4(1), SOS1(3)	306528	10	10	10	1	1	6	0	1	2	1.00	1.00
541	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	21	CASP10(2), DFFB(1)	95842	3	3	3	1	0	3	0	0	0	1.00	1.00
542	HSA00290_VALINE_ LEUCINE_AND_ISOLEUCINE_ BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	12	BCAT2(2), LARS(1), LARS2(2), VARS(3)	255722	8	6	8	1	1	5	1	0	1	1.00	1.00
543	HSA00240_PYRIMIDINE_ METABOLISM	Genes involved in pyrimidine metabolism	86	CAD(2), DPYS(2), NT5C2(1), NT5C3(2), NT5E(1), POLD1(1), POLR2A(2), POLR2F(1), RRM1(1), RRM2B(2)	493873	15	15	15	6	3	9	2	1	0	1.00	1.00
544	GLOBOSIDE_METABOLISM		13	ST3GAL4(1)	33837	1	1	1	1	0	1	0	0	0	1.00	1.00
545	KERATAN_SULFATE_ BIOSYNTHESIS		10	B4GALT3(1), B4GALT5(1), ST3GAL4(1)	102123	3	3	3	4	1	2	0	0	0	1.00	1.00
546	BLOOD_GROUP_GLYCOLIPID_ BIOSYNTHESIS_LACTOSERIES		7	FUT6(2)	69204	2	2	2	1	0	2	0	0	0	1.00	1.00
547	HSA00710_CARBON_ FIXATION	Genes involved in carbon fixation	23	PGK1(2)	70052	2	2	2	1	1	1	0	0	0	1.00	1.00
548	TRANSLATION_FACTORS		37	EEF1A2(1), EIF2B1(1), EIF2B3(1), EIF2B4(1), EIF4A1(1), EIF4G3(2), EIF5(1)	289002	8	8	8	3	0	5	1	0	2	1.00	1.00
549	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	9	EIF5(1)	37122	1	1	1	1	0	1	0	0	0	1.00	1.00
550	HSA00601_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	10	ST3GAL4(1)	37265	1	1	1	2	0	1	0	0	0	1.00	1.00
551	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	38	DLD(1), MAP2K5(1), MAP3K1(4), MAP3K11(1), MAP3K12(1)	309823	8	6	8	3	3	3	0	0	2	1.00	1.00
552	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	8	ACLY(1), PC(1)	83967	2	2	2	0	0	2	0	0	0	1.00	1.00
553	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	5	CHRM1(1), CHRNA1(2)	127293	3	3	3	1	0	3	0	0	0	1.00	1.00
554	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	10	LDHB(1), LDHC(1)	87868	2	2	2	1	0	2	0	0	0	1.00	1.00
555	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	8	STAT1(1)	44466	1	1	1	1	0	1	0	0	0	1.00	1.00
556	HSA00533_KERATAN_ SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	16	B4GALT3(1), ST3GAL4(1)	90065	2	2	2	4	1	1	0	0	0	1.00	1.00
557	MITOCHONDRIAL_FATTY_ ACID_BETAOXIDATION		15	ACSL3(1)	45694	1	1	1	2	0	1	0	0	0	1.00	1.00
558	NUCLEOTIDE_METABOLISM		14	POLD1(1), RRM1(1)	92218	2	2	2	1	1	1	0	0	0	1.00	1.00
559	GPCRDB_CLASS_A_RHODOPSIN_ LIKE2		13	GPR109B(2)	102990	2	2	2	0	0	2	0	0	0	1.00	1.00
560	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	23	CAMK2A(2), CAMK2D(1), CAMK4(1), PPP3CC(1), SLC2A4(1)	317527	6	5	6	3	3	2	0	0	1	1.00	1.00
561	1_AND_2_METHYLNAPHTHALENE_ DEGRADATION		7	ADH6(1)	52969	1	1	1	0	0	1	0	0	0	1.00	1.00
562	UBIQUITIN_MEDIATED_ PROTEOLYSIS		23	NRF1(1)	54355	1	1	1	0	0	1	0	0	0	1.00	1.00
563	HSA00531_GLYCOSAMINOGLYCAN_ DEGRADATION	Genes involved in glycosaminoglycan degradation	17	HGSNAT(1), HYAL1(3), NAGLU(1)	273701	5	5	5	1	0	3	0	1	1	1.00	1.00
564	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	12	WASL(1)	56120	1	1	1	0	0	1	0	0	0	1.00	1.00
565	MONOAMINE_GPCRS		32	CHRM1(1), HTR1D(1)	118295	2	2	2	0	1	1	0	0	0	1.00	1.00
566	HSA01032_GLYCAN_ STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	29	HGSNAT(1), HYAL1(3), NAGLU(1), NEU1(2)	429709	7	7	7	2	1	4	0	1	1	1.00	1.00
567	N_GLYCAN_DEGRADATION		13	NEU1(2)	130361	2	2	2	0	1	1	0	0	0	1.00	1.00
568	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	9	RAB5A(1)	66336	1	1	1	2	0	1	0	0	0	1.00	1.00
569	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	10	SNCAIP(2)	135265	2	2	2	0	0	2	0	0	0	1.00	1.00
570	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	23	POLR2A(2), POLR2F(1)	227569	3	3	3	1	1	1	0	1	0	1.00	1.00
571	RNA_POLYMERASE		14	POLR2A(2), POLR2F(1)	233558	3	3	3	1	1	1	0	1	0	1.00	1.00
572	RNA_TRANSCRIPTION_ REACTOME		37	GTF2H1(1), POLR2A(2), POLR2F(1)	318821	4	4	4	2	1	1	0	1	1	1.00	1.00
573	HSA00511_N_GLYCAN_ DEGRADATION	Genes involved in N-glycan degradation	15	NEU1(2)	179445	2	2	2	1	1	1	0	0	0	1.00	1.00
574	HSA00624_1_AND_2_ METHYLNAPHTHALENE_ DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	22	ADH6(1)	100005	1	1	1	3	0	1	0	0	0	1.00	1.00
575	HSA00930_CAPROLACTAM_ DEGRADATION	Genes involved in caprolactam degradation	13	HSD17B4(1)	113260	1	1	1	2	1	0	0	0	0	1.00	1.00
576	RIBOSOMAL_PROTEINS		94	RPS6KA2(2)	235933	2	2	2	1	0	1	0	1	0	1.00	1.00
577	HSA03010_RIBOSOME	Genes involved in ribosome	67	RPL22L1(1)	159500	1	1	1	1	1	0	0	0	0	1.00	1.00
578	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	5		13689	0	0	0	2	0	0	0	0	0	1.00	1.00
579	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	12		56114	0	0	0	0	0	0	0	0	0	1.00	1.00
580	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	16		8028	0	0	0	0	0	0	0	0	0	1.00	1.00
581	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	6		43096	0	0	0	0	0	0	0	0	0	1.00	1.00
582	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	6		13788	0	0	0	0	0	0	0	0	0	1.00	1.00
583	BIOSYNTHESIS_OF_ STEROIDS		14		20532	0	0	0	0	0	0	0	0	0	1.00	1.00
584	CAPROLACTAM_DEGRADATION		5		82610	0	0	0	2	0	0	0	0	0	1.00	1.00
585	CHOLESTEROL_BIOSYNTHESIS		15		19326	0	0	0	0	0	0	0	0	0	1.00	1.00
586	EICOSANOID_SYNTHESIS		17		15055	0	0	0	0	0	0	0	0	0	1.00	1.00
587	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	9		55160	0	0	0	0	0	0	0	0	0	1.00	1.00
588	FATTY_ACID_BIOSYNTHESIS_ PATH_2		9		46261	0	0	0	2	0	0	0	0	0	1.00	1.00
589	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	8		5779	0	0	0	0	0	0	0	0	0	1.00	1.00
590	FOSBPATHWAY	FOSB gene expression and drug abuse	5		29113	0	0	0	1	0	0	0	0	0	1.00	1.00
591	GLUTATHIONE_METABOLISM		31		97134	0	0	0	1	0	0	0	0	0	1.00	1.00
592	HEME_BIOSYNTHESIS		9		44493	0	0	0	0	0	0	0	0	0	1.00	1.00
593	HSA00100_BIOSYNTHESIS_ OF_STEROIDS	Genes involved in biosynthesis of steroids	24		30927	0	0	0	0	0	0	0	0	0	1.00	1.00
594	HSA00130_UBIQUINONE_ BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	8		20831	0	0	0	0	0	0	0	0	0	1.00	1.00
595	HSA00232_CAFFEINE_ METABOLISM	Genes involved in caffeine metabolism	7		29996	0	0	0	1	0	0	0	0	0	1.00	1.00
596	HSA00363_BISPHENOL_ A_DEGRADATION	Genes involved in bisphenol A degradation	14		42350	0	0	0	0	0	0	0	0	0	1.00	1.00
597	HSA00460_CYANOAMINO_ ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	6		14908	0	0	0	0	0	0	0	0	0	1.00	1.00
598	HSA00603_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	14		23437	0	0	0	0	0	0	0	0	0	1.00	1.00
599	HSA00604_GLYCOSPHINGOLIPID_ BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	16		23437	0	0	0	0	0	0	0	0	0	1.00	1.00
600	HSA00625_TETRACHLOROETHENE_ DEGRADATION	Genes involved in tetrachloroethene degradation	7		21122	0	0	0	0	0	0	0	0	0	1.00	1.00
601	HSA00642_ETHYLBENZENE_ DEGRADATION	Genes involved in ethylbenzene degradation	12		47036	0	0	0	3	0	0	0	0	0	1.00	1.00
602	HSA00791_ATRAZINE_ DEGRADATION	Genes involved in atrazine degradation	9		80286	0	0	0	0	0	0	0	0	0	1.00	1.00
603	HSA00900_TERPENOID_ BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	6		24700	0	0	0	0	0	0	0	0	0	1.00	1.00
604	HSA03060_PROTEIN_ EXPORT	Genes involved in protein export	8		17112	0	0	0	1	0	0	0	0	0	1.00	1.00
605	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	15		10974	0	0	0	0	0	0	0	0	0	1.00	1.00
606	HYPERTROPHY_MODEL		17		19055	0	0	0	1	0	0	0	0	0	1.00	1.00
607	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	19		26394	0	0	0	1	0	0	0	0	0	1.00	1.00
608	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	8		57749	0	0	0	2	0	0	0	0	0	1.00	1.00
609	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	9		75154	0	0	0	0	0	0	0	0	0	1.00	1.00
610	NUCLEOTIDE_GPCRS		8		63941	0	0	0	0	0	0	0	0	0	1.00	1.00
611	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	12		26299	0	0	0	0	0	0	0	0	0	1.00	1.00
612	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	9		4986	0	0	0	0	0	0	0	0	0	1.00	1.00
613	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	9		26299	0	0	0	0	0	0	0	0	0	1.00	1.00
614	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	6		30305	0	0	0	0	0	0	0	0	0	1.00	1.00
615	TERPENOID_BIOSYNTHESIS		4		14440	0	0	0	0	0	0	0	0	0	1.00	1.00
616	UBIQUINONE_BIOSYNTHESIS		15		62388	0	0	0	1	0	0	0	0	0	1.00	1.00

Notes: (Please see notes under significantly mutated gene table)