Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	MUTSIG_Significant_Genes	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
PCDHGA6	56109	broad.mit.edu	37	5	140756055	140756056	+	Missense_Mutation	DNP	GA	TT	TT			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140756055_140756056GA>TT	uc003ljy.1	+	1	2405_2406	c.2405_2406GA>TT	c.(2404-2406)GGA>GTT	p.G802V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.G802V	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	802	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---	capture		Missense_Mutation	DNP	140756055	140756056	11978	5	GA	TT	TT	41	41	PCDHGA6	TT	2	2
MLL2	8085	broad.mit.edu	37	12	49427160	49427160	+	Frame_Shift_Del	DEL	A	-	-			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49427160delA	uc001rta.3	-	39	11328	c.11328delT	c.(11326-11328)CTTfs	p.L3776fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3776	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---	capture_indel		Frame_Shift_Del	DEL	49427160	49427160	10011	12	A	-	-	13	13	MLL2	-	5	5
MSLNL	401827	broad.mit.edu	37	16	825541	825541	+	Frame_Shift_Del	DEL	C	-	-			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:825541delC	uc002cjz.1	-	5	1220	c.1220delG	c.(1219-1221)GGCfs	p.G407fs		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4																		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	825541	825541	10275	16	C	-	-	26	26	MSLNL	-	5	5
TMEM63B	55362	broad.mit.edu	37	6	44119666	44119666	+	Frame_Shift_Del	DEL	T	-	-			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44119666delT	uc003owr.2	+	19	1821	c.1757delT	c.(1756-1758)CTGfs	p.L586fs	TMEM63B_uc003ows.2_Frame_Shift_Del_p.L489fs|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	586						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)													OREG0017465	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---	capture_indel		Frame_Shift_Del	DEL	44119666	44119666	16730	6	T	-	-	55	55	TMEM63B	-	5	5
LZIC	84328	broad.mit.edu	37	1	9994882	9994882	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9994882G>T	uc001aqm.2	-	4	427	c.274C>A	c.(274-276)CCA>ACA	p.P92T	LZIC_uc001aqn.2_Intron|LZIC_uc001aqo.2_Missense_Mutation_p.P92T|LZIC_uc009vmr.2_Missense_Mutation_p.P92T|LZIC_uc010oah.1_Missense_Mutation_p.P113T	NM_032368	NP_115744	Q8WZA0	LZIC_HUMAN	leucine zipper and CTNNBIP1 domain containing	92							beta-catenin binding				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.29e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;0.000242)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.00842)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---	capture		Missense_Mutation	SNP	9994882	9994882	9512	1	G	T	T	43	43	LZIC	T	2	2
KAZ	23254	broad.mit.edu	37	1	15428077	15428077	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:15428077C>A	uc001avm.3	+	11	1867	c.1586C>A	c.(1585-1587)GCC>GAC	p.A529D	KAZ_uc001avs.3_5'UTR	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	529	SAM 2.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0																		---	---	---	---	capture		Missense_Mutation	SNP	15428077	15428077	8292	1	C	A	A	26	26	KAZ	A	2	2
EPHB2	2048	broad.mit.edu	37	1	23110939	23110939	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23110939G>C	uc009vqj.1	+	3	326	c.181G>C	c.(181-183)GTG>CTG	p.V61L	EPHB2_uc001bge.2_Missense_Mutation_p.V61L|EPHB2_uc001bgf.2_Missense_Mutation_p.V61L|EPHB2_uc010odu.1_Missense_Mutation_p.V61L	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	61	Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)										Hereditary_Prostate_Cancer				---	---	---	---	capture		Missense_Mutation	SNP	23110939	23110939	5368	1	G	C	C	44	44	EPHB2	C	3	3
C1orf201	90529	broad.mit.edu	37	1	24700234	24700234	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24700234G>T	uc001bjc.2	-	6	664	c.529C>A	c.(529-531)CAA>AAA	p.Q177K	C1orf201_uc010oej.1_Missense_Mutation_p.Q5K|C1orf201_uc001bja.2_Missense_Mutation_p.Q130K|C1orf201_uc001bjb.2_Missense_Mutation_p.Q85K|C1orf201_uc001bjd.2_Missense_Mutation_p.Q177K|C1orf201_uc001bje.1_Missense_Mutation_p.Q130K|C1orf201_uc001bjf.2_Missense_Mutation_p.Q45K			Q5TH74	CA201_HUMAN	RecName: Full=UPF0490 protein C1orf201;	177										ovary(1)|breast(1)	2		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.0191)|all_lung(284;0.0251)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.056)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.48e-25)|Colorectal(126;7.29e-08)|COAD - Colon adenocarcinoma(152;3.85e-06)|GBM - Glioblastoma multiforme(114;0.000399)|BRCA - Breast invasive adenocarcinoma(304;0.00107)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00393)|READ - Rectum adenocarcinoma(331;0.0672)|Lung(427;0.145)														---	---	---	---	capture		Missense_Mutation	SNP	24700234	24700234	2095	1	G	T	T	47	47	C1orf201	T	2	2
RAB42	115273	broad.mit.edu	37	1	28920446	28920446	+	Silent	SNP	C	T	T	rs148146932	byFrequency	TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28920446C>T	uc001bqu.2	+	2	441	c.135C>T	c.(133-135)ACC>ACT	p.T45T	RAB42_uc001bqv.2_Silent_p.T45T	NM_152304	NP_689517	Q8N4Z0	RAB42_HUMAN	RAB42, member RAS oncogene family	45					small GTPase mediated signal transduction	membrane	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00618)|all_lung(284;0.00909)|Breast(348;0.0249)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0577)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00298)|KIRC - Kidney renal clear cell carcinoma(1967;0.00948)|BRCA - Breast invasive adenocarcinoma(304;0.0213)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---	capture		Silent	SNP	28920446	28920446	13403	1	C	T	T	24	24	RAB42	T	2	2
EPB41	2035	broad.mit.edu	37	1	29385131	29385131	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29385131C>G	uc001brm.1	+	12	1883	c.1876C>G	c.(1876-1878)CCC>GCC	p.P626A	EPB41_uc001brg.1_Missense_Mutation_p.P417A|EPB41_uc001brh.1_Intron|EPB41_uc001bri.1_Intron|EPB41_uc001brj.1_Intron|EPB41_uc001brk.2_Missense_Mutation_p.P626A|EPB41_uc001brl.1_Intron|EPB41_uc009vtl.1_Intron|EPB41_uc009vtm.1_Intron	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	626	Spectrin--actin-binding.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)														---	---	---	---	capture		Missense_Mutation	SNP	29385131	29385131	5344	1	C	G	G	18	18	EPB41	G	3	3
MTF1	4520	broad.mit.edu	37	1	38288049	38288049	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38288049C>T	uc001cce.1	-	9	1652	c.1511G>A	c.(1510-1512)GGG>GAG	p.G504E	MTF1_uc009vvj.1_Missense_Mutation_p.G195E	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	504						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)																---	---	---	---	capture		Missense_Mutation	SNP	38288049	38288049	10315	1	C	T	T	22	22	MTF1	T	2	2
KCNQ4	9132	broad.mit.edu	37	1	41283949	41283949	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:41283949C>A	uc001cgh.1	+	3	601	c.519C>A	c.(517-519)CCC>CCA	p.P173P	KCNQ4_uc001cgi.1_Silent_p.P173P	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	173	Helical; Name=Segment S3; (Potential).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)															---	---	---	---	capture		Silent	SNP	41283949	41283949	8390	1	C	A	A	24	24	KCNQ4	A	2	2
LEPROT	54741	broad.mit.edu	37	1	65897531	65897531	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65897531A>G	uc001dcf.2	+	4	414	c.325A>G	c.(325-327)ATT>GTT	p.I109V	LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc001dci.2_Intron|LEPR_uc009waq.2_Intron|LEPROT_uc009wap.2_Missense_Mutation_p.I118V	NM_017526	NP_059996	O15243	OBRG_HUMAN	leptin receptor gene-related protein	109	Helical; (Potential).					endosome membrane|Golgi membrane|integral to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---	capture		Missense_Mutation	SNP	65897531	65897531	9056	1	A	G	G	8	8	LEPROT	G	4	4
LEPR	3953	broad.mit.edu	37	1	66102457	66102457	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:66102457A>G	uc001dci.2	+	20	3459	c.3257A>G	c.(3256-3258)AAA>AGA	p.K1086R	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	1086	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---	capture		Missense_Mutation	SNP	66102457	66102457	9052	1	A	G	G	1	1	LEPR	G	4	4
RPAP2	79871	broad.mit.edu	37	1	92798948	92798948	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92798948C>T	uc001dot.2	+	9	1565	c.1456C>T	c.(1456-1458)CAT>TAT	p.H486Y	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	486						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)														---	---	---	---	capture		Missense_Mutation	SNP	92798948	92798948	14021	1	C	T	T	25	25	RPAP2	T	2	2
FMO5	2330	broad.mit.edu	37	1	146658710	146658710	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:146658710G>T	uc001epi.2	-	9	1760	c.1371C>A	c.(1369-1371)CCC>CCA	p.P457P	FMO5_uc001eph.3_Intron|FMO5_uc001epj.2_3'UTR	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	457			P -> L.			integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)																	---	---	---	---	capture		Silent	SNP	146658710	146658710	6200	1	G	T	T	47	47	FMO5	T	2	2
OTUD7B	56957	broad.mit.edu	37	1	149916922	149916922	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:149916922C>G	uc001etn.2	-	12	1722	c.1366G>C	c.(1366-1368)GAT>CAT	p.D456H		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	456					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)															---	---	---	---	capture		Missense_Mutation	SNP	149916922	149916922	11732	1	C	G	G	32	32	OTUD7B	G	3	3
FCRL5	83416	broad.mit.edu	37	1	157508910	157508910	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:157508910G>T	uc001fqu.2	-	7	1526	c.1368C>A	c.(1366-1368)CCC>CCA	p.P456P	FCRL5_uc009wsm.2_Silent_p.P456P|FCRL5_uc010phv.1_Silent_p.P456P|FCRL5_uc010phw.1_Silent_p.P371P|FCRL5_uc001fqv.1_Silent_p.P456P|FCRL5_uc010phx.1_Silent_p.P207P	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	456	Extracellular (Potential).|Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)																---	---	---	---	capture		Silent	SNP	157508910	157508910	6035	1	G	T	T	43	43	FCRL5	T	2	2
OR10X1	128367	broad.mit.edu	37	1	158548923	158548923	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158548923G>C	uc010pin.1	-	1	767	c.767C>G	c.(766-768)ACC>AGC	p.T256S		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)																	---	---	---	---	capture		Missense_Mutation	SNP	158548923	158548923	11328	1	G	C	C	44	44	OR10X1	C	3	3
OR6N1	128372	broad.mit.edu	37	1	158735980	158735980	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158735980G>A	uc010piq.1	-	1	493	c.493C>T	c.(493-495)CGC>TGC	p.R165C		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)																	---	---	---	---	capture		Missense_Mutation	SNP	158735980	158735980	11616	1	G	A	A	40	40	OR6N1	A	1	1
RGS5	8490	broad.mit.edu	37	1	163172599	163172599	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:163172599G>T	uc001gcn.2	-	1	274	c.27C>A	c.(25-27)CCC>CCA	p.P9P	RGS5_uc009wvb.2_RNA	NM_003617	NP_003608	O15539	RGS5_HUMAN	regulator of G-protein signalling 5	9					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)															---	---	---	---	capture		Silent	SNP	163172599	163172599	13782	1	G	T	T	43	43	RGS5	T	2	2
RASAL2	9462	broad.mit.edu	37	1	178063816	178063816	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:178063816G>T	uc001glq.2	+	1	953	c.189G>T	c.(187-189)TGG>TGT	p.W63C	RASAL2_uc009wxb.2_Missense_Mutation_p.W63C|LOC100302401_uc001gln.1_5'Flank|LOC100302401_uc001glo.1_5'Flank|RASAL2_uc009wxa.2_RNA	NM_170692	NP_733793	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 2	Error:Variant_position_missing_in_Q9UJF2_after_alignment					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5																		---	---	---	---	capture		Missense_Mutation	SNP	178063816	178063816	13525	1	G	T	T	43	43	RASAL2	T	2	2
IVNS1ABP	10625	broad.mit.edu	37	1	185277948	185277948	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:185277948A>G	uc001grl.2	-	5	964	c.341T>C	c.(340-342)ATG>ACG	p.M114T	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	114					interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5																		---	---	---	---	capture		Missense_Mutation	SNP	185277948	185277948	8234	1	A	G	G	8	8	IVNS1ABP	G	4	4
PRG4	10216	broad.mit.edu	37	1	186276489	186276489	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186276489C>A	uc001gru.3	+	7	1689	c.1638C>A	c.(1636-1638)CCC>CCA	p.P546P	PRG4_uc001grt.3_Silent_p.P505P|PRG4_uc009wyl.2_Silent_p.P453P|PRG4_uc009wym.2_Silent_p.P412P|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	546	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|26; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1																		---	---	---	---	capture		Silent	SNP	186276489	186276489	12924	1	C	A	A	21	21	PRG4	A	2	2
CFH	3075	broad.mit.edu	37	1	196684863	196684863	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196684863G>A	uc001gtj.3	+	11	1900	c.1660G>A	c.(1660-1662)GGT>AGT	p.G554S		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	554	Sushi 9.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6																		---	---	---	---	capture		Missense_Mutation	SNP	196684863	196684863	3416	1	G	A	A	47	47	CFH	A	2	2
CFHR5	81494	broad.mit.edu	37	1	196965332	196965332	+	Splice_Site	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196965332G>C	uc001gts.3	+	6	1098	c.970_splice	c.e6+1	p.A324_splice		NM_030787	NP_110414			complement factor H-related 5 precursor						complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2																		---	---	---	---	capture		Splice_Site	SNP	196965332	196965332	3421	1	G	C	C	44	44	CFHR5	C	5	3
ATP2B4	493	broad.mit.edu	37	1	203681203	203681203	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203681203G>T	uc001gzw.2	+	13	3031	c.2147G>T	c.(2146-2148)GGG>GTG	p.G716V	ATP2B4_uc001gzv.2_Missense_Mutation_p.G716V|ATP2B4_uc009xaq.2_Missense_Mutation_p.G716V	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	716	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)															---	---	---	---	capture		Missense_Mutation	SNP	203681203	203681203	1161	1	G	T	T	43	43	ATP2B4	T	2	2
ELK4	2005	broad.mit.edu	37	1	205589867	205589867	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205589867C>A	uc001hcy.1	-	3	1557	c.307G>T	c.(307-309)GGT>TGT	p.G103C	ELK4_uc001hcz.2_Missense_Mutation_p.G103C	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	103						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)					T	SLC45A3	prostate								---	---	---	---	capture		Missense_Mutation	SNP	205589867	205589867	5253	1	C	A	A	22	22	ELK4	A	2	2
CDC42BPA	8476	broad.mit.edu	37	1	227381487	227381487	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227381487C>A	uc001hqr.2	-	5	1542	c.599G>T	c.(598-600)AGA>ATA	p.R200I	CDC42BPA_uc001hqs.2_Missense_Mutation_p.R200I|CDC42BPA_uc009xes.2_Missense_Mutation_p.R200I|CDC42BPA_uc010pvs.1_Missense_Mutation_p.R200I	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	200	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)																---	---	---	---	capture		Missense_Mutation	SNP	227381487	227381487	3200	1	C	A	A	24	24	CDC42BPA	A	2	2
TOMM20	9804	broad.mit.edu	37	1	235291986	235291986	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235291986G>A	uc001hwl.2	-	1	271	c.45C>T	c.(43-45)GCC>GCT	p.A15A	SNORA14B_uc001hwm.1_5'Flank	NM_014765	NP_055580	Q15388	TOM20_HUMAN	translocase of outer mitochondrial membrane 20	15	Helical; (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|unfolded protein binding				0	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;6.33e-05)|Epithelial(3;8.26e-05)															---	---	---	---	capture		Silent	SNP	235291986	235291986	16895	1	G	A	A	43	43	TOMM20	A	2	2
ZP4	57829	broad.mit.edu	37	1	238045822	238045822	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:238045822C>A	uc001hym.2	-	12	1523	c.1523G>T	c.(1522-1524)TGG>TTG	p.W508L	LOC100130331_uc010pyc.1_RNA	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	508	Helical; (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)															---	---	---	---	capture		Missense_Mutation	SNP	238045822	238045822	18822	1	C	A	A	21	21	ZP4	A	2	2
EXO1	9156	broad.mit.edu	37	1	242035336	242035336	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242035336G>T	uc001hzh.2	+	12	1810	c.1270G>T	c.(1270-1272)GAG>TAG	p.E424*	EXO1_uc001hzi.2_Nonsense_Mutation_p.E424*|EXO1_uc001hzj.2_Nonsense_Mutation_p.E424*|EXO1_uc009xgq.2_Splice_Site_p.E423_splice	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	424	Interaction with MLH1.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)										Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---	capture		Nonsense_Mutation	SNP	242035336	242035336	5493	1	G	T	T	33	33	EXO1	T	5	2
OR6F1	343169	broad.mit.edu	37	1	247875736	247875736	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247875736C>A	uc001idj.1	-	1	322	c.322G>T	c.(322-324)GGC>TGC	p.G108C		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)															---	---	---	---	capture		Missense_Mutation	SNP	247875736	247875736	11611	1	C	A	A	24	24	OR6F1	A	2	2
OR2T6	254879	broad.mit.edu	37	1	248551758	248551758	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248551758C>A	uc001iei.1	+	1	849	c.849C>A	c.(847-849)CCC>CCA	p.P283P		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)															---	---	---	---	capture		Silent	SNP	248551758	248551758	11435	1	C	A	A	24	24	OR2T6	A	2	2
ANKRD30A	91074	broad.mit.edu	37	10	37508523	37508523	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:37508523A>G	uc001iza.1	+	34	3814	c.3715A>G	c.(3715-3717)ATG>GTG	p.M1239V		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1295	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9																		---	---	---	---	capture		Missense_Mutation	SNP	37508523	37508523	663	10	A	G	G	4	4	ANKRD30A	G	4	4
PGBD3	267004	broad.mit.edu	37	10	50723876	50723876	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50723876G>T	uc001jht.2	-	2	1540	c.1285C>A	c.(1285-1287)CAT>AAT	p.H429N	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Missense_Mutation_p.H897N|PGBD3_uc001jhu.2_Missense_Mutation_p.H897N	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	429										pancreas(1)|breast(1)|skin(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	50723876	50723876	12205	10	G	T	T	47	47	PGBD3	T	2	2
PRKG1	5592	broad.mit.edu	37	10	54048748	54048748	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54048748G>A	uc001jjm.2	+	16	2039	c.1845G>A	c.(1843-1845)AAG>AAA	p.K615K	PRKG1_uc001jjo.2_Silent_p.K630K|PRKG1_uc009xow.1_Silent_p.K333K|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	615	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)														---	---	---	---	capture		Silent	SNP	54048748	54048748	12965	10	G	A	A	34	34	PRKG1	A	2	2
BICC1	80114	broad.mit.edu	37	10	60546717	60546717	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:60546717A>T	uc001jki.1	+	5	422	c.422A>T	c.(421-423)CAT>CTT	p.H141L		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	141	KH 1.				multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	60546717	60546717	1452	10	A	T	T	8	8	BICC1	T	4	4
ANK3	288	broad.mit.edu	37	10	61835211	61835211	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61835211C>A	uc001jky.2	-	37	5620	c.5428G>T	c.(5428-5430)GCA>TCA	p.A1810S	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1810	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---	capture		Missense_Mutation	SNP	61835211	61835211	625	10	C	A	A	25	25	ANK3	A	2	2
LRIT2	340745	broad.mit.edu	37	10	85982088	85982088	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85982088C>A	uc001kcy.2	-	3	1249	c.1241G>T	c.(1240-1242)GGA>GTA	p.G414V	LRIT2_uc010qmc.1_Missense_Mutation_p.G424V	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	414	Fibronectin type-III.					integral to membrane				ovary(2)	2																		---	---	---	---	capture		Missense_Mutation	SNP	85982088	85982088	9321	10	C	A	A	30	30	LRIT2	A	2	2
SLK	9748	broad.mit.edu	37	10	105779491	105779491	+	Splice_Site	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105779491G>T	uc001kxo.1	+	16	3167	c.3133_splice	c.e16-1	p.E1045_splice	SLK_uc001kxp.1_Splice_Site_p.E1014_splice	NM_014720	NP_055535			serine/threonine kinase 2						apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)														---	---	---	---	capture		Splice_Site	SNP	105779491	105779491	15246	10	G	T	T	35	35	SLK	T	5	2
AFAP1L2	84632	broad.mit.edu	37	10	116060044	116060044	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116060044G>C	uc001lbn.2	-	15	2167	c.1866C>G	c.(1864-1866)ATC>ATG	p.I622M	AFAP1L2_uc001lbo.2_Missense_Mutation_p.I622M|AFAP1L2_uc010qse.1_Missense_Mutation_p.I675M|AFAP1L2_uc001lbp.2_Missense_Mutation_p.I650M|AFAP1L2_uc001lbr.1_Missense_Mutation_p.I621M|AFAP1L2_uc001lbm.2_Missense_Mutation_p.I61M|AFAP1L2_uc010qsd.1_Missense_Mutation_p.I188M|AFAP1L2_uc001lbq.1_Missense_Mutation_p.I144M	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	622					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)														---	---	---	---	capture		Missense_Mutation	SNP	116060044	116060044	356	10	G	C	C	33	33	AFAP1L2	C	3	3
DOCK1	1793	broad.mit.edu	37	10	129237453	129237453	+	Silent	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129237453C>T	uc001ljt.2	+	49	5224	c.5160C>T	c.(5158-5160)TCC>TCT	p.S1720S	DOCK1_uc010qun.1_Silent_p.S1741S|DOCK1_uc009yaq.2_Silent_p.S715S	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1720					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)														---	---	---	---	capture		Silent	SNP	129237453	129237453	4868	10	C	T	T	22	22	DOCK1	T	2	2
KNDC1	85442	broad.mit.edu	37	10	135027589	135027589	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135027589G>T	uc001llz.1	+	26	4641	c.4640G>T	c.(4639-4641)TGG>TTG	p.W1547L		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1547	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)														---	---	---	---	capture		Missense_Mutation	SNP	135027589	135027589	8740	10	G	T	T	47	47	KNDC1	T	2	2
MUC6	4588	broad.mit.edu	37	11	1031985	1031985	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1031985C>G	uc001lsw.2	-	3	235	c.184G>C	c.(184-186)GAC>CAC	p.D62H		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	62	VWFD 1.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---	capture		Missense_Mutation	SNP	1031985	1031985	10374	11	C	G	G	31	31	MUC6	G	3	3
MUC5B	727897	broad.mit.edu	37	11	1248602	1248602	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1248602C>A	uc009ycr.1	+	22	2735	c.2609C>A	c.(2608-2610)CCG>CAG	p.P870Q	MUC5B_uc009yct.1_Missense_Mutation_p.P214Q|MUC5B_uc001ltb.2_Missense_Mutation_p.P214Q|MUC5B_uc001lta.2_5'Flank	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	214	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---	capture		Missense_Mutation	SNP	1248602	1248602	10373	11	C	A	A	23	23	MUC5B	A	1	1
OR52K2	119774	broad.mit.edu	37	11	4471455	4471455	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4471455G>A	uc001lyz.1	+	1	886	c.886G>A	c.(886-888)GTC>ATC	p.V296I		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	296	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---	capture		Missense_Mutation	SNP	4471455	4471455	11534	11	G	A	A	48	48	OR52K2	A	2	2
OR52J3	119679	broad.mit.edu	37	11	5068652	5068652	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5068652G>T	uc010qyv.1	+	1	897	c.897G>T	c.(895-897)CAG>CAT	p.Q299H		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---	capture		Missense_Mutation	SNP	5068652	5068652	11532	11	G	T	T	33	33	OR52J3	T	2	2
WT1	7490	broad.mit.edu	37	11	32439126	32439126	+	Missense_Mutation	SNP	T	G	G	rs67297380		TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:32439126T>G	uc001mtn.1	-	4	1143	c.947A>C	c.(946-948)AAG>ACG	p.K316T	WT1_uc001mtl.1_Missense_Mutation_p.K104T|WT1_uc001mtm.1_Missense_Mutation_p.K104T|WT1_uc001mto.1_Missense_Mutation_p.K316T|WT1_uc001mtp.1_Missense_Mutation_p.K316T|WT1_uc001mtq.1_Missense_Mutation_p.K316T|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	248					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.E316fs*4(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)					D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				---	---	---	---	capture		Missense_Mutation	SNP	32439126	32439126	17982	11	T	G	G	56	56	WT1	G	4	4
FOLH1	2346	broad.mit.edu	37	11	49175867	49175867	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49175867C>T	uc001ngy.2	-	16	2062	c.1801G>A	c.(1801-1803)GCT>ACT	p.A601T	FOLH1_uc001ngx.2_Missense_Mutation_p.A33T|FOLH1_uc001ngz.2_Missense_Mutation_p.A601T|FOLH1_uc009yly.2_Missense_Mutation_p.A586T|FOLH1_uc009ylz.2_Missense_Mutation_p.A586T|FOLH1_uc009yma.2_Missense_Mutation_p.A293T	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	601	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)													---	---	---	---	capture		Missense_Mutation	SNP	49175867	49175867	6221	11	C	T	T	25	25	FOLH1	T	2	2
OR5M3	219482	broad.mit.edu	37	11	56237681	56237681	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56237681T>C	uc010rjk.1	-	1	293	c.293A>G	c.(292-294)CAG>CGG	p.Q98R		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	98	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)																	---	---	---	---	capture		Missense_Mutation	SNP	56237681	56237681	11585	11	T	C	C	55	55	OR5M3	C	4	4
AHNAK	79026	broad.mit.edu	37	11	62288412	62288412	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62288412C>T	uc001ntl.2	-	5	13777	c.13477G>A	c.(13477-13479)GTA>ATA	p.V4493I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4493					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---	capture		Missense_Mutation	SNP	62288412	62288412	417	11	C	T	T	18	18	AHNAK	T	2	2
CDK2AP2	10263	broad.mit.edu	37	11	67275064	67275064	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67275064T>A	uc001oma.2	-	2	728	c.179A>T	c.(178-180)CAG>CTG	p.Q60L	PITPNM1_uc001oly.2_5'Flank|PITPNM1_uc001olz.2_5'Flank|CDK2AP2_uc009yry.2_RNA|CDK2AP2_uc001omb.2_Missense_Mutation_p.Q69L	NM_005851	NP_005842	O75956	CDKA2_HUMAN	cyclin-dependent kinase 2 associated protein 2	60											0																		---	---	---	---	capture		Missense_Mutation	SNP	67275064	67275064	3268	11	T	A	A	55	55	CDK2AP2	A	4	4
TYR	7299	broad.mit.edu	37	11	89017960	89017960	+	Nonsense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89017960C>T	uc001pcs.2	+	4	1286	c.1204C>T	c.(1204-1206)CGA>TGA	p.R402*		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	402	Lumenal, melanosome (Potential).		R -> L (in OCA1A).|R -> G (in OCA1B).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)									Oculocutaneous_Albinism				---	---	---	---	capture		Nonsense_Mutation	SNP	89017960	89017960	17370	11	C	T	T	23	23	TYR	T	5	1
ACAT1	38	broad.mit.edu	37	11	108004595	108004595	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108004595G>T	uc001pjy.2	+	3	245	c.169G>T	c.(169-171)GGC>TGC	p.G57C	ACAT1_uc001pjw.1_Missense_Mutation_p.G57C|ACAT1_uc001pjx.2_Translation_Start_Site	NM_000019	NP_000010	P24752	THIL_HUMAN	acetyl-Coenzyme A acetyltransferase 1 precursor	57					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)													---	---	---	---	capture		Missense_Mutation	SNP	108004595	108004595	122	11	G	T	T	35	35	ACAT1	T	2	2
ALG9	79796	broad.mit.edu	37	11	111706942	111706942	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111706942G>T	uc001pmb.2	-	14	1626	c.1527C>A	c.(1525-1527)ACC>ACA	p.T509T	ALG9_uc001ply.2_Silent_p.T338T|ALG9_uc001plz.2_Silent_p.T345T|ALG9_uc010rwm.1_Silent_p.T516T|ALG9_uc010rwn.1_Silent_p.T463T|ALG9_uc010rwo.1_Silent_p.T337T	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	509	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)														---	---	---	---	capture		Silent	SNP	111706942	111706942	527	11	G	T	T	43	43	ALG9	T	2	2
OR4D5	219875	broad.mit.edu	37	11	123811094	123811094	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123811094C>A	uc001pzk.1	+	1	771	c.771C>A	c.(769-771)GTC>GTA	p.V257V		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)														---	---	---	---	capture		Silent	SNP	123811094	123811094	11464	11	C	A	A	32	32	OR4D5	A	2	2
EI24	9538	broad.mit.edu	37	11	125448101	125448101	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125448101G>T	uc001qca.2	+	6	631	c.389G>T	c.(388-390)TGG>TTG	p.W130L	EI24_uc001qcb.2_Missense_Mutation_p.W130L|EI24_uc010sbd.1_RNA|EI24_uc009zbl.2_Missense_Mutation_p.W130L|EI24_uc001qcc.2_RNA|EI24_uc010sbe.1_Missense_Mutation_p.W116L|EI24_uc010sbf.1_RNA	NM_004879	NP_004870	O14681	EI24_HUMAN	etoposide induced 2.4 isoform 1	130	Helical; (Potential).				apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)														---	---	---	---	capture		Missense_Mutation	SNP	125448101	125448101	5174	11	G	T	T	47	47	EI24	T	2	2
TMEM45B	120224	broad.mit.edu	37	11	129722407	129722407	+	Silent	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:129722407A>G	uc001qfe.1	+	2	91	c.30A>G	c.(28-30)CCA>CCG	p.P10P	TMEM45B_uc001qff.1_Silent_p.P10P	NM_138788	NP_620143	Q96B21	TM45B_HUMAN	transmembrane protein 45B	10	Helical; (Potential).					integral to membrane					0	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)														---	---	---	---	capture		Silent	SNP	129722407	129722407	16709	11	A	G	G	7	7	TMEM45B	G	4	4
ADAMTS15	170689	broad.mit.edu	37	11	130343024	130343024	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:130343024G>T	uc010scd.1	+	8	2161	c.2161G>T	c.(2161-2163)GGG>TGG	p.G721W		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	721	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)														---	---	---	---	capture		Missense_Mutation	SNP	130343024	130343024	261	11	G	T	T	39	39	ADAMTS15	T	1	1
SPSB2	84727	broad.mit.edu	37	12	6981615	6981615	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6981615G>T	uc001qrl.2	-	2	607	c.451C>A	c.(451-453)CAG>AAG	p.Q151K	SPSB2_uc001qrm.2_Missense_Mutation_p.Q151K|SPSB2_uc010sfp.1_Missense_Mutation_p.Q151K|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	151	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1																OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---	capture		Missense_Mutation	SNP	6981615	6981615	15627	12	G	T	T	47	47	SPSB2	T	2	2
MFAP5	8076	broad.mit.edu	37	12	8813482	8813482	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8813482A>T	uc001qut.1	-	3	284	c.71T>A	c.(70-72)CTG>CAG	p.L24Q	MFAP5_uc001qus.2_Missense_Mutation_p.L24Q|MFAP5_uc009zge.1_Missense_Mutation_p.L24Q	NM_003480	NP_003471	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5 precursor	24						microfibril	extracellular matrix structural constituent			breast(1)	1	Lung SC(5;0.184)																	---	---	---	---	capture		Missense_Mutation	SNP	8813482	8813482	9908	12	A	T	T	7	7	MFAP5	T	4	4
PZP	5858	broad.mit.edu	37	12	9305507	9305507	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9305507G>T	uc001qvl.2	-	31	4063	c.4034C>A	c.(4033-4035)TCC>TAC	p.S1345Y	PZP_uc009zgl.2_Missense_Mutation_p.S1131Y	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5																		---	---	---	---	capture		Missense_Mutation	SNP	9305507	9305507	13327	12	G	T	T	41	41	PZP	T	2	2
PRB1	5542	broad.mit.edu	37	12	11506883	11506883	+	Missense_Mutation	SNP	G	T	T	rs141106766		TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:11506883G>T	uc001qzw.1	-	3	191	c.154C>A	c.(154-156)CCT>ACT	p.P52T	PRB1_uc001qzu.1_Missense_Mutation_p.P52T|PRB1_uc001qzv.1_Missense_Mutation_p.P52T	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	52						extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)															---	---	---	---	capture		Missense_Mutation	SNP	11506883	11506883	12884	12	G	T	T	44	44	PRB1	T	2	2
PTPRO	5800	broad.mit.edu	37	12	15654661	15654661	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:15654661G>A	uc001rcv.1	+	5	943	c.769G>A	c.(769-771)GAT>AAT	p.D257N	PTPRO_uc001rcw.1_Missense_Mutation_p.D257N|PTPRO_uc001rcu.1_Missense_Mutation_p.D257N	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	257	Fibronectin type-III 3.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)																---	---	---	---	capture		Missense_Mutation	SNP	15654661	15654661	13266	12	G	A	A	33	33	PTPRO	A	2	2
CCNT1	904	broad.mit.edu	37	12	49086827	49086827	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49086827G>T	uc001rse.1	-	9	2493	c.2170C>A	c.(2170-2172)CTT>ATT	p.L724I	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.L439I	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	724	Pro-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6																		---	---	---	---	capture		Missense_Mutation	SNP	49086827	49086827	3061	12	G	T	T	35	35	CCNT1	T	2	2
MCRS1	10445	broad.mit.edu	37	12	49953272	49953272	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49953272C>A	uc001ruk.1	-	12	1241	c.1050G>T	c.(1048-1050)CGG>CGT	p.R350R	MCRS1_uc001rui.1_Silent_p.R363R|MCRS1_uc001ruj.1_Silent_p.R337R|MCRS1_uc001rul.1_Silent_p.R350R|MCRS1_uc009zlj.1_Silent_p.R159R|MCRS1_uc001rum.1_Silent_p.R337R	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	350					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1																		---	---	---	---	capture		Silent	SNP	49953272	49953272	9788	12	C	A	A	22	22	MCRS1	A	2	2
RPS26	6231	broad.mit.edu	37	12	56436328	56436328	+	Missense_Mutation	SNP	T	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56436328T>G	uc001sjf.2	+	2	388	c.123T>G	c.(121-123)ATT>ATG	p.I41M		NM_001029	NP_001020	P62854	RS26_HUMAN	ribosomal protein S26	41					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|protein binding|structural constituent of ribosome			breast(1)	1			OV - Ovarian serous cystadenocarcinoma(18;0.123)															---	---	---	---	capture		Missense_Mutation	SNP	56436328	56436328	14117	12	T	G	G	62	62	RPS26	G	4	4
ATP5B	506	broad.mit.edu	37	12	57033843	57033843	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57033843G>T	uc001slr.2	-	8	1313	c.1208C>A	c.(1207-1209)TCC>TAC	p.S403Y		NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	403					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	57033843	57033843	1167	12	G	T	T	41	41	ATP5B	T	2	2
SLC16A7	9194	broad.mit.edu	37	12	60169075	60169075	+	Silent	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:60169075G>C	uc001sqs.2	+	5	1298	c.999G>C	c.(997-999)CTG>CTC	p.L333L	SLC16A7_uc001sqt.2_Silent_p.L333L|SLC16A7_uc001squ.2_Silent_p.L333L|SLC16A7_uc009zqi.2_Silent_p.L234L|SLC16A7_uc010ssi.1_Silent_p.L234L	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	333	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)													---	---	---	---	capture		Silent	SNP	60169075	60169075	14909	12	G	C	C	47	47	SLC16A7	C	3	3
ACSS3	79611	broad.mit.edu	37	12	81624881	81624881	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81624881G>T	uc001szl.1	+	12	1651	c.1560G>T	c.(1558-1560)CAG>CAT	p.Q520H	ACSS3_uc001szm.1_Missense_Mutation_p.Q519H|ACSS3_uc001szn.1_Missense_Mutation_p.Q202H	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	520						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	81624881	81624881	191	12	G	T	T	35	35	ACSS3	T	2	2
PPFIA2	8499	broad.mit.edu	37	12	81833821	81833821	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81833821C>A	uc001szo.1	-	7	736	c.575G>T	c.(574-576)AGG>ATG	p.R192M	PPFIA2_uc010sue.1_Missense_Mutation_p.R92M|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_Intron|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	118										ovary(3)|lung(2)|pancreas(1)	6																		---	---	---	---	capture		Missense_Mutation	SNP	81833821	81833821	12740	12	C	A	A	24	24	PPFIA2	A	2	2
LRRIQ1	84125	broad.mit.edu	37	12	85547831	85547831	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85547831G>T	uc001tac.2	+	23	4790	c.4679G>T	c.(4678-4680)AGG>ATG	p.R1560M		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1560										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)														---	---	---	---	capture		Missense_Mutation	SNP	85547831	85547831	9405	12	G	T	T	35	35	LRRIQ1	T	2	2
RASSF9	9182	broad.mit.edu	37	12	86199109	86199109	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:86199109C>A	uc001taf.1	-	2	1018	c.679G>T	c.(679-681)GGA>TGA	p.G227*		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	227	Potential.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1																		---	---	---	---	capture		Nonsense_Mutation	SNP	86199109	86199109	13554	12	C	A	A	21	21	RASSF9	A	5	2
C12orf63	374467	broad.mit.edu	37	12	97150340	97150340	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:97150340G>T	uc001tet.1	+	24	3298	c.3220G>T	c.(3220-3222)GGA>TGA	p.G1074*		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1074										skin(6)|ovary(1)	7																		---	---	---	---	capture		Nonsense_Mutation	SNP	97150340	97150340	1750	12	G	T	T	35	35	C12orf63	T	5	2
STAB2	55576	broad.mit.edu	37	12	104136220	104136220	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104136220G>T	uc001tjw.2	+	56	6105	c.5919G>T	c.(5917-5919)CGG>CGT	p.R1973R	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1973	Extracellular (Potential).|Laminin EGF-like 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14																		---	---	---	---	capture		Silent	SNP	104136220	104136220	15756	12	G	T	T	43	43	STAB2	T	2	2
POLR3B	55703	broad.mit.edu	37	12	106889912	106889912	+	Silent	SNP	A	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:106889912A>C	uc001tlp.2	+	24	3015	c.2793A>C	c.(2791-2793)CCA>CCC	p.P931P	POLR3B_uc001tlq.2_Silent_p.P873P	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	931					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---	capture		Silent	SNP	106889912	106889912	12657	12	A	C	C	6	6	POLR3B	C	4	4
CRY1	1407	broad.mit.edu	37	12	107391092	107391092	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:107391092G>T	uc001tmi.3	-	10	2424	c.1565C>A	c.(1564-1566)CCA>CAA	p.P522Q		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	522					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3																		---	---	---	---	capture		Missense_Mutation	SNP	107391092	107391092	4042	12	G	T	T	47	47	CRY1	T	2	2
HVCN1	84329	broad.mit.edu	37	12	111099042	111099042	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111099042G>T	uc001trs.1	-	4	398	c.233C>A	c.(232-234)CCT>CAT	p.P78H	HVCN1_uc001trq.1_Missense_Mutation_p.P78H|HVCN1_uc001trt.1_Missense_Mutation_p.P78H|HVCN1_uc010syd.1_Missense_Mutation_p.P58H	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	78	Cytoplasmic (Potential).				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	111099042	111099042	7762	12	G	T	T	35	35	HVCN1	T	2	2
CCDC63	160762	broad.mit.edu	37	12	111342552	111342552	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111342552C>A	uc001trv.1	+	11	1698	c.1503C>A	c.(1501-1503)CCC>CCA	p.P501P	CCDC63_uc010sye.1_Silent_p.P461P|CCDC63_uc001trw.1_Silent_p.P416P	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	501										skin(6)|ovary(1)|pancreas(1)	8																		---	---	---	---	capture		Silent	SNP	111342552	111342552	2957	12	C	A	A	22	22	CCDC63	A	2	2
ATXN2	6311	broad.mit.edu	37	12	111893858	111893858	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111893858G>T	uc001tsj.2	-	23	3881	c.3719C>A	c.(3718-3720)CCA>CAA	p.P1240Q	ATXN2_uc001tsh.2_Missense_Mutation_p.P975Q|ATXN2_uc001tsi.2_Missense_Mutation_p.P933Q|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Missense_Mutation_p.P428Q|ATXN2_uc001tsl.1_Missense_Mutation_p.P241Q	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	1240					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2																		---	---	---	---	capture		Missense_Mutation	SNP	111893858	111893858	1231	12	G	T	T	47	47	ATXN2	T	2	2
KSR2	283455	broad.mit.edu	37	12	118199246	118199246	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:118199246C>A	uc001two.2	-	4	524	c.469G>T	c.(469-471)GAG>TAG	p.E157*		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	186	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---	capture		Nonsense_Mutation	SNP	118199246	118199246	8905	12	C	A	A	30	30	KSR2	A	5	2
RIMBP2	23504	broad.mit.edu	37	12	130897317	130897317	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130897317C>A	uc001uil.2	-	15	2832	c.2668G>T	c.(2668-2670)GAC>TAC	p.D890Y		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	890	SH3 2.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)														---	---	---	---	capture		Missense_Mutation	SNP	130897317	130897317	13838	12	C	A	A	32	32	RIMBP2	A	2	2
EP400	57634	broad.mit.edu	37	12	132516566	132516566	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132516566C>A	uc001ujn.2	+	29	5858	c.5823C>A	c.(5821-5823)ACC>ACA	p.T1941T	EP400_uc001ujl.2_Silent_p.T1940T|EP400_uc001ujm.2_Silent_p.T1860T	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1977	Helicase C-terminal.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)														---	---	---	---	capture		Silent	SNP	132516566	132516566	5342	12	C	A	A	21	21	EP400	A	2	2
GPR12	2835	broad.mit.edu	37	13	27333452	27333452	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:27333452C>A	uc010aal.2	-	2	735	c.513G>T	c.(511-513)CTG>CTT	p.L171L	GPR12_uc010tdl.1_Silent_p.L12L	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	171	Helical; Name=4; (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)														---	---	---	---	capture		Silent	SNP	27333452	27333452	6909	13	C	A	A	21	21	GPR12	A	2	2
KBTBD6	89890	broad.mit.edu	37	13	41706151	41706151	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41706151C>A	uc001uxu.1	-	1	786	c.497G>T	c.(496-498)CGA>CTA	p.R166L	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.R100L|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	166							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)														---	---	---	---	capture		Missense_Mutation	SNP	41706151	41706151	8302	13	C	A	A	31	31	KBTBD6	A	1	1
KCTD4	386618	broad.mit.edu	37	13	45768460	45768460	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:45768460C>G	uc001uzx.3	-	2	647	c.243G>C	c.(241-243)AGG>AGC	p.R81S	GTF2F2_uc001uzv.2_Intron|GTF2F2_uc001uzw.2_Intron	NM_198404	NP_940686	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerisation domain	81	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)														---	---	---	---	capture		Missense_Mutation	SNP	45768460	45768460	8417	13	C	G	G	22	22	KCTD4	G	3	3
OR4L1	122742	broad.mit.edu	37	14	20528227	20528227	+	Silent	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20528227A>G	uc001vwn.1	+	1	24	c.24A>G	c.(22-24)CTA>CTG	p.L8L		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)														---	---	---	---	capture		Silent	SNP	20528227	20528227	11484	14	A	G	G	15	15	OR4L1	G	4	4
RALGAPA1	253959	broad.mit.edu	37	14	36159126	36159126	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36159126C>A	uc001wti.2	-	17	2741	c.2350G>T	c.(2350-2352)GGT>TGT	p.G784C	RALGAPA1_uc001wtj.2_Missense_Mutation_p.G784C|RALGAPA1_uc010tpv.1_Missense_Mutation_p.G784C|RALGAPA1_uc010tpw.1_Missense_Mutation_p.G831C|RALGAPA1_uc001wtk.1_Missense_Mutation_p.G682C	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	784					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	36159126	36159126	13473	14	C	A	A	21	21	RALGAPA1	A	2	2
C14orf28	122525	broad.mit.edu	37	14	45369749	45369749	+	Silent	SNP	T	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45369749T>G	uc001wvo.2	+	2	377	c.111T>G	c.(109-111)GCT>GCG	p.A37A	C14orf28_uc001wvp.1_Silent_p.A37A	NM_001017923	NP_001017923	Q4W4Y0	CN028_HUMAN	hypothetical protein LOC122525	37										ovary(1)	1																		---	---	---	---	capture		Silent	SNP	45369749	45369749	1819	14	T	G	G	55	55	C14orf28	G	4	4
ALDH6A1	4329	broad.mit.edu	37	14	74537937	74537937	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74537937G>T	uc001xpo.2	-	6	790	c.691C>A	c.(691-693)CCT>ACT	p.P231T	C14orf45_uc001xpm.1_Intron|ALDH6A1_uc010asa.2_Missense_Mutation_p.P76T|ALDH6A1_uc010tuq.1_Missense_Mutation_p.P218T	NM_005589	NP_005580	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6A1 precursor	231						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)													---	---	---	---	capture		Missense_Mutation	SNP	74537937	74537937	506	14	G	T	T	43	43	ALDH6A1	T	2	2
C14orf49	161176	broad.mit.edu	37	14	95905456	95905456	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95905456C>A	uc001yei.3	-	13	2305	c.2290G>T	c.(2290-2292)GGG>TGG	p.G764W	C14orf49_uc010avi.2_Missense_Mutation_p.G764W	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	764	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)														---	---	---	---	capture		Missense_Mutation	SNP	95905456	95905456	1826	14	C	A	A	22	22	C14orf49	A	2	2
AK7	122481	broad.mit.edu	37	14	96864475	96864475	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96864475G>A	uc001yfn.2	+	2	213	c.169G>A	c.(169-171)GAT>AAT	p.D57N	AK7_uc001yfm.1_Missense_Mutation_p.D57N	NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	57	Poly-Glu.|Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)														---	---	---	---	capture		Missense_Mutation	SNP	96864475	96864475	447	14	G	A	A	33	33	AK7	A	2	2
C15orf2	23742	broad.mit.edu	37	15	24921171	24921171	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:24921171C>A	uc001ywo.2	+	1	631	c.157C>A	c.(157-159)CGG>AGG	p.R53R		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	53					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)														---	---	---	---	capture		Silent	SNP	24921171	24921171	1834	15	C	A	A	23	23	C15orf2	A	1	1
APBA2	321	broad.mit.edu	37	15	29346098	29346098	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:29346098G>T	uc001zck.2	+	3	218	c.11G>T	c.(10-12)CGG>CTG	p.R4L	APBA2_uc010azj.2_Missense_Mutation_p.R4L|APBA2_uc010uat.1_Missense_Mutation_p.R4L|APBA2_uc001zcl.2_Missense_Mutation_p.R4L|APBA2_uc010uas.1_Missense_Mutation_p.R4L	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	4					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)														---	---	---	---	capture		Missense_Mutation	SNP	29346098	29346098	767	15	G	T	T	39	39	APBA2	T	1	1
BUB1B	701	broad.mit.edu	37	15	40462841	40462841	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40462841T>C	uc001zkx.3	+	4	555	c.343T>C	c.(343-345)TAT>CAT	p.Y115H		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	115	BUB1 N-terminal.|Nuclear localization signal (Potential).				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)				Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---	capture		Missense_Mutation	SNP	40462841	40462841	1605	15	T	C	C	49	49	BUB1B	C	4	4
GLDN	342035	broad.mit.edu	37	15	51696499	51696499	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51696499C>A	uc002aba.2	+	10	1373	c.1204C>A	c.(1204-1206)CAA>AAA	p.Q402K	GLDN_uc002abb.2_Missense_Mutation_p.Q278K	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	402	Extracellular (Potential).|Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)														---	---	---	---	capture		Missense_Mutation	SNP	51696499	51696499	6702	15	C	A	A	21	21	GLDN	A	2	2
UNC13C	440279	broad.mit.edu	37	15	54305912	54305912	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54305912A>G	uc002ack.2	+	1	812	c.812A>G	c.(811-813)AAG>AGG	p.K271R		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	271					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---	capture		Missense_Mutation	SNP	54305912	54305912	17544	15	A	G	G	3	3	UNC13C	G	4	4
SCAPER	49855	broad.mit.edu	37	15	77092589	77092589	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77092589C>A	uc002bby.2	-	6	670	c.611G>T	c.(610-612)GGA>GTA	p.G204V	SCAPER_uc002bbx.2_5'UTR|SCAPER_uc002bbz.1_Missense_Mutation_p.G69V|SCAPER_uc002bca.1_Missense_Mutation_p.G69V|SCAPER_uc002bcb.1_Missense_Mutation_p.G204V|SCAPER_uc002bcc.1_Missense_Mutation_p.G204V	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	203						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	77092589	77092589	14359	15	C	A	A	22	22	SCAPER	A	2	2
PSTPIP1	9051	broad.mit.edu	37	15	77328172	77328172	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77328172G>A	uc002bcf.2	+	14	1465	c.1015G>A	c.(1015-1017)GAG>AAG	p.E339K	PSTPIP1_uc010bkt.1_RNA|PSTPIP1_uc010bku.1_Missense_Mutation_p.E330K|PSTPIP1_uc002bcg.2_Missense_Mutation_p.E336K|PSTPIP1_uc010bkw.1_Missense_Mutation_p.E320K|PSTPIP1_uc002bch.1_Missense_Mutation_p.E100K|PSTPIP1_uc002bci.1_RNA	NM_003978	NP_003969	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting	339					cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			ovary(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	77328172	77328172	13175	15	G	A	A	37	37	PSTPIP1	A	1	1
IL16	3603	broad.mit.edu	37	15	81598288	81598288	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:81598288G>T	uc002bgh.3	+	17	3836	c.3460G>T	c.(3460-3462)GGG>TGG	p.G1154W	IL16_uc010blq.1_Missense_Mutation_p.G1108W|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.G1196W|IL16_uc002bgg.2_Missense_Mutation_p.G1154W|IL16_uc002bgi.1_Missense_Mutation_p.G544W|IL16_uc002bgj.2_Missense_Mutation_p.G648W|IL16_uc002bgk.2_Missense_Mutation_p.G453W|IL16_uc002bgl.1_Missense_Mutation_p.G453W|IL16_uc010unq.1_Missense_Mutation_p.G453W	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1154	PDZ 3.|Interaction with PPP1R12A, PPP1R12B and PPP1R12C.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	81598288	81598288	7934	15	G	T	T	35	35	IL16	T	2	2
PCSK6	5046	broad.mit.edu	37	15	101933589	101933589	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101933589C>A	uc002bwy.2	-	9	1351	c.1037G>T	c.(1036-1038)GGG>GTG	p.G346V	PCSK6_uc010bpd.2_Missense_Mutation_p.G216V|PCSK6_uc010bpe.2_Missense_Mutation_p.G346V|PCSK6_uc002bxa.2_Missense_Mutation_p.G346V|PCSK6_uc002bxb.2_Missense_Mutation_p.G346V|PCSK6_uc002bxc.1_Missense_Mutation_p.G346V|PCSK6_uc002bxd.1_Missense_Mutation_p.G346V|PCSK6_uc002bxe.2_Missense_Mutation_p.G346V|PCSK6_uc002bxg.1_Missense_Mutation_p.G346V	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	346	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---	capture		Missense_Mutation	SNP	101933589	101933589	12025	15	C	A	A	22	22	PCSK6	A	2	2
PKD1	5310	broad.mit.edu	37	16	2141865	2141865	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2141865G>A	uc002cos.1	-	41	11663	c.11454C>T	c.(11452-11454)GGC>GGT	p.G3818G	PKD1_uc002cot.1_Silent_p.G3817G|MIR1225_hsa-mir-1225|MI0006311_5'Flank|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3818	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3																		---	---	---	---	capture		Silent	SNP	2141865	2141865	12387	16	G	A	A	34	34	PKD1	A	2	2
TRAF7	84231	broad.mit.edu	37	16	2225505	2225505	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2225505G>T	uc002cow.2	+	17	1607	c.1508G>T	c.(1507-1509)TGG>TTG	p.W503L		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	503	WD 3.				activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	2225505	2225505	16990	16	G	T	T	47	47	TRAF7	T	2	2
SRRM2	23524	broad.mit.edu	37	16	2816580	2816580	+	Silent	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2816580C>T	uc002crk.2	+	11	6600	c.6051C>T	c.(6049-6051)CGC>CGT	p.R2017R	SRRM2_uc002crj.1_Silent_p.R1921R|SRRM2_uc002crl.1_Silent_p.R2017R|SRRM2_uc010bsu.1_Silent_p.R1921R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2017	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---	capture		Silent	SNP	2816580	2816580	15683	16	C	T	T	28	28	SRRM2	T	2	2
ACSM5	54988	broad.mit.edu	37	16	20430682	20430682	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20430682G>A	uc002dhe.2	+	4	695	c.548G>A	c.(547-549)TGC>TAC	p.C183Y	ACSM5_uc002dhd.1_Missense_Mutation_p.C183Y	NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	183					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2																		---	---	---	---	capture		Missense_Mutation	SNP	20430682	20430682	188	16	G	A	A	46	46	ACSM5	A	2	2
TNRC6A	27327	broad.mit.edu	37	16	24802987	24802987	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24802987G>T	uc002dmm.2	+	6	3138	c.3024G>T	c.(3022-3024)TGG>TGT	p.W1008C	TNRC6A_uc010bxs.2_Missense_Mutation_p.W755C|TNRC6A_uc010vcc.1_Missense_Mutation_p.W755C|TNRC6A_uc002dmn.2_Missense_Mutation_p.W755C|TNRC6A_uc002dmo.2_Missense_Mutation_p.W755C	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1008	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)														---	---	---	---	capture		Missense_Mutation	SNP	24802987	24802987	16881	16	G	T	T	43	43	TNRC6A	T	2	2
GTF3C1	2975	broad.mit.edu	37	16	27518417	27518417	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27518417C>A	uc002dov.1	-	9	1343	c.1303G>T	c.(1303-1305)GAG>TAG	p.E435*	GTF3C1_uc002dou.2_Nonsense_Mutation_p.E435*	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	435						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5																		---	---	---	---	capture		Nonsense_Mutation	SNP	27518417	27518417	7152	16	C	A	A	32	32	GTF3C1	A	5	2
SLC5A2	6524	broad.mit.edu	37	16	31500246	31500246	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31500246C>A	uc002ecf.3	+	11	1345	c.1326C>A	c.(1324-1326)CCC>CCA	p.P442P	SLC5A2_uc010car.2_Intron|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	442	Helical; (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1																		---	---	---	---	capture		Silent	SNP	31500246	31500246	15162	16	C	A	A	23	23	SLC5A2	A	1	1
ABCC12	94160	broad.mit.edu	37	16	48142361	48142361	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48142361C>A	uc002efc.1	-	17	2707	c.2361G>T	c.(2359-2361)AAG>AAT	p.K787N	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	787						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)																---	---	---	---	capture		Missense_Mutation	SNP	48142361	48142361	53	16	C	A	A	24	24	ABCC12	A	2	2
TOX3	27324	broad.mit.edu	37	16	52473644	52473644	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:52473644G>T	uc002egw.2	-	7	1395	c.1224C>A	c.(1222-1224)CCC>CCA	p.P408P	TOX3_uc010vgt.1_Silent_p.P403P|TOX3_uc010vgu.1_Silent_p.P408P	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	408					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0																		---	---	---	---	capture		Silent	SNP	52473644	52473644	16921	16	G	T	T	35	35	TOX3	T	2	2
RBL2	5934	broad.mit.edu	37	16	53524121	53524121	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53524121G>A	uc002ehi.3	+	22	3447	c.3329G>A	c.(3328-3330)AGT>AAT	p.S1110N	RBL2_uc002ehj.2_Missense_Mutation_p.S820N|RBL2_uc010vgw.1_Missense_Mutation_p.S489N	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1110					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5																		---	---	---	---	capture		Missense_Mutation	SNP	53524121	53524121	13571	16	G	A	A	36	36	RBL2	A	2	2
DPEP2	64174	broad.mit.edu	37	16	68023977	68023977	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68023977G>T	uc010cey.2	-	7	1131	c.967C>A	c.(967-969)CCA>ACA	p.P323T	DPEP2_uc002evd.3_Missense_Mutation_p.P323T|DPEP2_uc002eve.2_Missense_Mutation_p.P323T|DPEP2_uc002evf.2_RNA	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	323					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)														---	---	---	---	capture		Missense_Mutation	SNP	68023977	68023977	4898	16	G	T	T	43	43	DPEP2	T	2	2
HYDIN	54768	broad.mit.edu	37	16	70843862	70843862	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70843862C>A	uc002ezr.2	-	85	14832	c.14704G>T	c.(14704-14706)GGA>TGA	p.G4902*	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4903										ovary(1)|skin(1)	2		Ovarian(137;0.0654)																---	---	---	---	capture		Nonsense_Mutation	SNP	70843862	70843862	7767	16	C	A	A	23	23	HYDIN	A	5	1
TP53	7157	broad.mit.edu	37	17	7577580	7577580	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7577580T>C	uc002gim.2	-	7	895	c.701A>G	c.(700-702)TAC>TGC	p.Y234C	TP53_uc002gig.1_Missense_Mutation_p.Y234C|TP53_uc002gih.2_Missense_Mutation_p.Y234C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y102C|TP53_uc010cng.1_Missense_Mutation_p.Y102C|TP53_uc002gii.1_Missense_Mutation_p.Y102C|TP53_uc010cnh.1_Missense_Mutation_p.Y234C|TP53_uc010cni.1_Missense_Mutation_p.Y234C|TP53_uc002gij.2_Missense_Mutation_p.Y234C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y141C|TP53_uc002gio.2_Missense_Mutation_p.Y102C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	234	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> F (in a sporadic cancer; somatic mutation).|Y -> K (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|Y -> N (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> Q (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y234C(70)|p.Y234H(13)|p.Y234N(11)|p.0?(7)|p.Y234S(6)|p.Y234*(4)|p.Y234D(3)|p.Y234del(3)|p.Y234fs*2(1)|p.V225fs*23(1)|p.Y234fs*6(1)|p.Y234fs*5(1)|p.Y234fs*4(1)|p.Y234R(1)|p.Y234Y(1)|p.H233_C242del10(1)|p.D228fs*12(1)|p.Y234F(1)|p.I232_Y236delIHYNY(1)|p.Y141S(1)|p.T230_Y234delTTIHY(1)|p.H233fs*6(1)|p.Y234_N235insX(1)|p.I232fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)			111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---	---	capture		Missense_Mutation	SNP	7577580	7577580	16923	17	T	C	C	57	57	TP53	C	4	4
ADORA2B	136	broad.mit.edu	37	17	15878625	15878625	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15878625G>T	uc002gpd.1	+	2	1300	c.968G>T	c.(967-969)GGG>GTG	p.G323V		NM_000676	NP_000667	P29275	AA2BR_HUMAN	adenosine A2b receptor	323	Cytoplasmic (By similarity).				activation of MAPK activity|cellular defense response|excretion|JNK cascade	integral to plasma membrane				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0855)	Defibrotide(DB04932)|Enprofylline(DB00824)|Pegademase bovine(DB00061)|Theophylline(DB00277)													---	---	---	---	capture		Missense_Mutation	SNP	15878625	15878625	329	17	G	T	T	43	43	ADORA2B	T	2	2
MAP2K3	5606	broad.mit.edu	37	17	21204224	21204224	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:21204224G>A	uc002gys.2	+	5	583	c.318G>A	c.(316-318)CGG>CGA	p.R106R	MAP2K3_uc002gyt.2_Silent_p.R77R|MAP2K3_uc002gyu.2_Silent_p.R77R	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	106	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)														---	---	---	---	capture		Silent	SNP	21204224	21204224	9621	17	G	A	A	42	42	MAP2K3	A	2	2
ACACA	31	broad.mit.edu	37	17	35591902	35591902	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35591902G>A	uc002hnm.2	-	25	3314	c.3123C>T	c.(3121-3123)GTC>GTT	p.V1041V	ACACA_uc002hnk.2_Silent_p.V963V|ACACA_uc002hnl.2_Silent_p.V983V|ACACA_uc002hnn.2_Silent_p.V1041V|ACACA_uc002hno.2_Silent_p.V1078V|ACACA_uc010cuz.2_Silent_p.V1041V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1041					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---	capture		Silent	SNP	35591902	35591902	107	17	G	A	A	45	45	ACACA	A	2	2
CACNB1	782	broad.mit.edu	37	17	37333659	37333659	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37333659G>T	uc002hrm.1	-	13	1429	c.1276C>A	c.(1276-1278)CGC>AGC	p.R426S	CACNB1_uc002hrl.1_Missense_Mutation_p.R198S|CACNB1_uc002hrn.2_Missense_Mutation_p.R426S|CACNB1_uc002hro.2_Missense_Mutation_p.R471S	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	426					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)													---	---	---	---	capture		Missense_Mutation	SNP	37333659	37333659	2668	17	G	T	T	39	39	CACNB1	T	1	1
ITGB3	3690	broad.mit.edu	37	17	45369758	45369758	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45369758G>A	uc002ilj.2	+	10	1534	c.1514G>A	c.(1513-1515)CGC>CAC	p.R505H	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	505	I.|Extracellular (Potential).|Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)													---	---	---	---	capture		Missense_Mutation	SNP	45369758	45369758	8199	17	G	A	A	38	38	ITGB3	A	1	1
C17orf57	124989	broad.mit.edu	37	17	45447834	45447834	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45447834A>G	uc002iln.2	+	11	1248	c.837A>G	c.(835-837)ATA>ATG	p.I279M	C17orf57_uc002ilm.2_Missense_Mutation_p.I183M|C17orf57_uc002ill.1_Missense_Mutation_p.I35M|C17orf57_uc010daz.1_Missense_Mutation_p.I231M	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	279							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	45447834	45447834	1922	17	A	G	G	16	16	C17orf57	G	4	4
KPNB1	3837	broad.mit.edu	37	17	45747078	45747078	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45747078C>A	uc002ilt.1	+	11	1595	c.1259C>A	c.(1258-1260)CCC>CAC	p.P420H	KPNB1_uc010wkw.1_Missense_Mutation_p.P275H|KPNB1_uc010wkx.1_Missense_Mutation_p.P204H	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	420	HEAT 6.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	45747078	45747078	8750	17	C	A	A	22	22	KPNB1	A	2	2
KCNJ16	3773	broad.mit.edu	37	17	68129006	68129006	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:68129006G>T	uc002jin.2	+	5	1264	c.778G>T	c.(778-780)GAG>TAG	p.E260*	KCNJ16_uc002jio.2_Nonsense_Mutation_p.E260*|KCNJ16_uc002jip.2_Nonsense_Mutation_p.E260*|KCNJ16_uc002jiq.2_Nonsense_Mutation_p.E292*	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	260	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)																	---	---	---	---	capture		Nonsense_Mutation	SNP	68129006	68129006	8355	17	G	T	T	45	45	KCNJ16	T	5	2
ITGB4	3691	broad.mit.edu	37	17	73736921	73736921	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73736921G>T	uc002jpg.2	+	22	2785	c.2598G>T	c.(2596-2598)CAG>CAT	p.Q866H	ITGB4_uc002jph.2_Missense_Mutation_p.Q866H|ITGB4_uc010dgo.2_Missense_Mutation_p.Q866H|ITGB4_uc002jpi.3_Missense_Mutation_p.Q866H|ITGB4_uc010dgp.1_Missense_Mutation_p.D879Y|ITGB4_uc002jpj.2_Missense_Mutation_p.Q866H	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	866	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---	capture		Missense_Mutation	SNP	73736921	73736921	8201	17	G	T	T	33	33	ITGB4	T	2	2
QRICH2	84074	broad.mit.edu	37	17	74287768	74287768	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74287768G>T	uc002jrd.1	-	4	2722	c.2542C>A	c.(2542-2544)CCT>ACT	p.P848T	QRICH2_uc010wsz.1_Missense_Mutation_p.P774T|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	848							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---	capture		Missense_Mutation	SNP	74287768	74287768	13338	17	G	T	T	41	41	QRICH2	T	2	2
UBE2O	63893	broad.mit.edu	37	17	74394358	74394358	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74394358C>A	uc002jrm.3	-	12	2068	c.2003G>T	c.(2002-2004)GGG>GTG	p.G668V	UBE2O_uc002jrn.3_Missense_Mutation_p.G668V|UBE2O_uc002jrl.3_Missense_Mutation_p.G271V	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	668							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5																OREG0024751	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---	capture		Missense_Mutation	SNP	74394358	74394358	17425	17	C	A	A	22	22	UBE2O	A	2	2
SLC25A10	1468	broad.mit.edu	37	17	79671373	79671373	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79671373G>T	uc010wut.1	+	2	299	c.174G>T	c.(172-174)AAG>AAT	p.K58N	MRPL12_uc002kbh.1_Missense_Mutation_p.K58N	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	Error:Variant_position_missing_in_Q9UBX3_after_alignment					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)													---	---	---	---	capture		Missense_Mutation	SNP	79671373	79671373	14969	17	G	T	T	35	35	SLC25A10	T	2	2
ZFP161	7541	broad.mit.edu	37	18	5291634	5291634	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:5291634G>T	uc002kmq.2	-	4	734	c.573C>A	c.(571-573)CCC>CCA	p.P191P	ZFP161_uc002kmr.2_Silent_p.P191P|ZFP161_uc010dkp.2_Silent_p.P191P	NM_003409	NP_003400	O43829	ZF161_HUMAN	zinc finger protein 161 homolog	191					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---	capture		Silent	SNP	5291634	5291634	18228	18	G	T	T	47	47	ZFP161	T	2	2
LAMA3	3909	broad.mit.edu	37	18	21422480	21422480	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21422480G>T	uc002kuq.2	+	28	3544	c.3458G>T	c.(3457-3459)CGG>CTG	p.R1153L	LAMA3_uc002kur.2_Missense_Mutation_p.R1153L	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1153	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---	capture		Missense_Mutation	SNP	21422480	21422480	8930	18	G	T	T	39	39	LAMA3	T	1	1
ZCCHC2	54877	broad.mit.edu	37	18	60223502	60223502	+	Silent	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:60223502C>T	uc002lip.3	+	6	1380	c.1380C>T	c.(1378-1380)TCC>TCT	p.S460S	ZCCHC2_uc002lio.2_RNA	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	460					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2																		---	---	---	---	capture		Silent	SNP	60223502	60223502	18175	18	C	T	T	21	21	ZCCHC2	T	2	2
LRG1	116844	broad.mit.edu	37	19	4538521	4538521	+	Missense_Mutation	SNP	A	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4538521A>C	uc002mau.2	-	2	486	c.475T>G	c.(475-477)TGG>GGG	p.W159G	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	159	LRR 3.					extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---	capture		Missense_Mutation	SNP	4538521	4538521	9315	19	A	C	C	6	6	LRG1	C	4	4
MUC16	94025	broad.mit.edu	37	19	9025609	9025609	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9025609C>A	uc002mkp.2	-	15	37049	c.36845G>T	c.(36844-36846)TGC>TTC	p.C12282F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12284	SEA 2.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---	capture		Missense_Mutation	SNP	9025609	9025609	10367	19	C	A	A	25	25	MUC16	A	2	2
CALR	811	broad.mit.edu	37	19	13051633	13051633	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13051633G>T	uc002mvu.2	+	7	972	c.892G>T	c.(892-894)GAG>TAG	p.E298*	CALR_uc002mvv.2_5'Flank	NM_004343	NP_004334	P27797	CALR_HUMAN	calreticulin precursor	298	P-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---	capture		Nonsense_Mutation	SNP	13051633	13051633	2709	19	G	T	T	37	37	CALR	T	5	1
INSL3	3640	broad.mit.edu	37	19	17927797	17927797	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17927797C>A	uc002nhm.1	-	2	267	c.262G>T	c.(262-264)GGA>TGA	p.G88*	INSL3_uc010ebf.1_Missense_Mutation_p.W119C|INSL3_uc010ebg.1_RNA	NM_005543	NP_005534	P51460	INSL3_HUMAN	insulin-like 3 precursor	88					cell-cell signaling|spermatogenesis	soluble fraction	hormone activity|insulin receptor binding|signal transducer activity				0																		---	---	---	---	capture		Nonsense_Mutation	SNP	17927797	17927797	8068	19	C	A	A	22	22	INSL3	A	5	2
SLC5A5	6528	broad.mit.edu	37	19	17983413	17983413	+	Silent	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17983413T>A	uc002nhr.3	+	1	632	c.285T>A	c.(283-285)CTT>CTA	p.L95L		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	95	Helical; (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---	capture		Silent	SNP	17983413	17983413	15165	19	T	A	A	62	62	SLC5A5	A	4	4
NCAN	1463	broad.mit.edu	37	19	19337671	19337671	+	Silent	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19337671C>T	uc002nlz.2	+	7	1548	c.1449C>T	c.(1447-1449)TTC>TTT	p.F483F	NCAN_uc010ecc.1_Silent_p.F47F	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	483					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)															---	---	---	---	capture		Silent	SNP	19337671	19337671	10603	19	C	T	T	29	29	NCAN	T	2	2
ZNF14	7561	broad.mit.edu	37	19	19823162	19823162	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19823162T>C	uc002nnk.1	-	4	1082	c.928A>G	c.(928-930)AAA>GAA	p.K310E		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	310	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)																---	---	---	---	capture		Missense_Mutation	SNP	19823162	19823162	18319	19	T	C	C	61	61	ZNF14	C	4	4
ZNF431	170959	broad.mit.edu	37	19	21366712	21366712	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21366712A>G	uc002npp.2	+	5	1753	c.1606A>G	c.(1606-1608)AGA>GGA	p.R536G	ZNF431_uc010ecq.2_Missense_Mutation_p.R445G|ZNF431_uc010ecr.2_Missense_Mutation_p.R537G	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	536					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2																		---	---	---	---	capture		Missense_Mutation	SNP	21366712	21366712	18498	19	A	G	G	15	15	ZNF431	G	4	4
ZNF208	7757	broad.mit.edu	37	19	22154642	22154642	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22154642G>T	uc002nqp.2	-	6	2959	c.2810C>A	c.(2809-2811)GCC>GAC	p.A937D	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)																---	---	---	---	capture		Missense_Mutation	SNP	22154642	22154642	18357	19	G	T	T	42	42	ZNF208	T	2	2
ZNF461	92283	broad.mit.edu	37	19	37149214	37149214	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37149214G>A	uc002oem.2	-	3	351	c.123C>T	c.(121-123)AAC>AAT	p.N41N	ZNF461_uc002oen.2_Intron|ZNF461_uc010xtj.1_Silent_p.N41N	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)															---	---	---	---	capture		Silent	SNP	37149214	37149214	18518	19	G	A	A	36	36	ZNF461	A	2	2
HNRNPL	3191	broad.mit.edu	37	19	39338037	39338037	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39338037G>T	uc010xul.1	-	2	316	c.305C>A	c.(304-306)CCA>CAA	p.P102Q	HNRNPL_uc010xum.1_5'UTR	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	102	RRM 1.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)															---	---	---	---	capture		Missense_Mutation	SNP	39338037	39338037	7562	19	G	T	T	47	47	HNRNPL	T	2	2
TTC9B	148014	broad.mit.edu	37	19	40722081	40722081	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40722081C>T	uc002onc.2	-	3	727	c.709G>A	c.(709-711)GTA>ATA	p.V237I		NM_152479	NP_689692	Q8N6N2	TTC9B_HUMAN	tetratricopeptide repeat domain 9B	237							binding				0																		---	---	---	---	capture		Missense_Mutation	SNP	40722081	40722081	17271	19	C	T	T	17	17	TTC9B	T	2	2
AKT2	208	broad.mit.edu	37	19	40747908	40747908	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40747908C>A	uc002onf.2	-	6	772	c.510G>T	c.(508-510)CGG>CGT	p.R170R	AKT2_uc010egs.2_Silent_p.R170R|AKT2_uc010egt.2_Silent_p.R108R|AKT2_uc010xvj.1_Silent_p.R108R|AKT2_uc010egu.1_Silent_p.R108R|AKT2_uc010xvk.1_Silent_p.R170R|AKT2_uc002one.2_Silent_p.R66R	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	170	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)					A		ovarian|pancreatic 								---	---	---	---	capture		Silent	SNP	40747908	40747908	483	19	C	A	A	22	22	AKT2	A	2	2
CEACAM16	388551	broad.mit.edu	37	19	45207358	45207358	+	Silent	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45207358T>A	uc010xxd.1	+	4	659	c.453T>A	c.(451-453)CTT>CTA	p.L151L	CEACAM16_uc002ozq.2_Silent_p.L210L	NM_001039213	NP_001034302	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion	151										ovary(1)	1	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)																---	---	---	---	capture		Silent	SNP	45207358	45207358	3321	19	T	A	A	61	61	CEACAM16	A	4	4
TOMM40	10452	broad.mit.edu	37	19	45396132	45396132	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45396132C>A	uc002ozx.3	+	4	482	c.381C>A	c.(379-381)TCC>TCA	p.S127S	TOMM40_uc002ozy.3_Silent_p.S127S|TOMM40_uc002paa.3_Silent_p.S127S|TOMM40_uc002ozz.2_Silent_p.S127S	NM_006114	NP_006105	O96008	TOM40_HUMAN	translocase of outer mitochondrial membrane 40	127					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)														---	---	---	---	capture		Silent	SNP	45396132	45396132	16899	19	C	A	A	21	21	TOMM40	A	2	2
ZNF611	81856	broad.mit.edu	37	19	53209454	53209454	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53209454T>C	uc002pzz.2	-	7	1171	c.854A>G	c.(853-855)AAA>AGA	p.K285R	ZNF611_uc010eqc.2_Missense_Mutation_p.K215R|ZNF611_uc010ydo.1_Missense_Mutation_p.K215R|ZNF611_uc010ydr.1_Missense_Mutation_p.K216R|ZNF611_uc010ydp.1_Missense_Mutation_p.K285R|ZNF611_uc010ydq.1_Missense_Mutation_p.K285R|ZNF611_uc002qaa.3_Missense_Mutation_p.K215R	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)														---	---	---	---	capture		Missense_Mutation	SNP	53209454	53209454	18632	19	T	C	C	64	64	ZNF611	C	4	4
ZNF28	7576	broad.mit.edu	37	19	53304566	53304566	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53304566G>T	uc002qad.2	-	4	652	c.532C>A	c.(532-534)CAA>AAA	p.Q178K	ZNF28_uc002qac.2_Missense_Mutation_p.Q125K|ZNF28_uc010eqe.2_Missense_Mutation_p.Q124K	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)														---	---	---	---	capture		Missense_Mutation	SNP	53304566	53304566	18405	19	G	T	T	47	47	ZNF28	T	2	2
CACNG8	59283	broad.mit.edu	37	19	54466592	54466592	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54466592C>A	uc002qcs.1	+	1	299	c.193C>A	c.(193-195)CCC>ACC	p.P65T		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	66					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)														---	---	---	---	capture		Missense_Mutation	SNP	54466592	54466592	2679	19	C	A	A	22	22	CACNG8	A	2	2
LILRB5	10990	broad.mit.edu	37	19	54760477	54760477	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54760477G>T	uc002qex.2	-	3	341	c.230C>A	c.(229-231)CCT>CAT	p.P77H	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.P77H|LILRB5_uc002qey.2_Missense_Mutation_p.P77H|LILRB5_uc002qez.2_Missense_Mutation_p.P77H|LILRB5_uc002qfa.1_Missense_Mutation_p.P67H|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	77	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)														---	---	---	---	capture		Missense_Mutation	SNP	54760477	54760477	9120	19	G	T	T	35	35	LILRB5	T	2	2
NLRP8	126205	broad.mit.edu	37	19	56459307	56459307	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56459307C>A	uc002qmh.2	+	1	110	c.39C>A	c.(37-39)CCC>CCA	p.P13P	NLRP8_uc010etg.2_Silent_p.P13P	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	13						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)														---	---	---	---	capture		Silent	SNP	56459307	56459307	10886	19	C	A	A	24	24	NLRP8	A	2	2
TRIM28	10155	broad.mit.edu	37	19	59061103	59061103	+	Splice_Site	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:59061103G>T	uc002qtg.1	+	14	2272	c.1983_splice	c.e14-1	p.G661_splice	TRIM28_uc010eut.1_Splice_Site_p.G579_splice|TRIM28_uc002qth.1_Splice_Site_p.G276_splice	NM_005762	NP_005753			tripartite motif-containing 28 protein						epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)														---	---	---	---	capture		Splice_Site	SNP	59061103	59061103	17046	19	G	T	T	35	35	TRIM28	T	5	2
MYT1L	23040	broad.mit.edu	37	2	1842979	1842979	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1842979G>T	uc002qxe.2	-	21	3849	c.3022C>A	c.(3022-3024)CCC>ACC	p.P1008T	MYT1L_uc002qxd.2_Missense_Mutation_p.P1006T|MYT1L_uc010ewk.2_Missense_Mutation_p.P4T	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1008	C2HC-type 6.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)														---	---	---	---	capture		Missense_Mutation	SNP	1842979	1842979	10502	2	G	T	T	43	43	MYT1L	T	2	2
KIDINS220	57498	broad.mit.edu	37	2	8871217	8871217	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:8871217T>C	uc002qzc.2	-	30	5131	c.4949A>G	c.(4948-4950)AAG>AGG	p.K1650R	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.K1551R|KIDINS220_uc002qzb.2_Missense_Mutation_p.K504R	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1650	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---	capture		Missense_Mutation	SNP	8871217	8871217	8582	2	T	C	C	56	56	KIDINS220	C	4	4
ASXL2	55252	broad.mit.edu	37	2	25965124	25965124	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25965124G>A	uc002rgs.2	-	12	4303	c.4082C>T	c.(4081-4083)TCA>TTA	p.S1361L	ASXL2_uc002rgt.1_Missense_Mutation_p.S844L	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	1361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---	capture		Missense_Mutation	SNP	25965124	25965124	1086	2	G	A	A	45	45	ASXL2	A	2	2
ZNF513	130557	broad.mit.edu	37	2	27603054	27603054	+	Silent	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27603054T>C	uc002rkk.2	-	2	317	c.117A>G	c.(115-117)CTA>CTG	p.L39L	ZNF513_uc002rkj.2_5'UTR	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	39					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---	capture		Silent	SNP	27603054	27603054	18552	2	T	C	C	57	57	ZNF513	C	4	4
ABCG8	64241	broad.mit.edu	37	2	44104801	44104801	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44104801C>A	uc002rtq.2	+	12	1948	c.1858C>A	c.(1858-1860)CTC>ATC	p.L620I	ABCG8_uc010yoa.1_Missense_Mutation_p.L619I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	620	ABC transmembrane type-2.|Extracellular (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)														OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---	capture		Missense_Mutation	SNP	44104801	44104801	73	2	C	A	A	24	24	ABCG8	A	2	2
TET3	200424	broad.mit.edu	37	2	74300734	74300734	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74300734G>T	uc002skb.3	+	2	2148	c.2148G>T	c.(2146-2148)ACG>ACT	p.T716T	TET3_uc010fez.1_Silent_p.T716T	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	716							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0																		---	---	---	---	capture		Silent	SNP	74300734	74300734	16298	2	G	T	T	39	39	TET3	T	1	1
DNAH6	1768	broad.mit.edu	37	2	84785056	84785056	+	Silent	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84785056A>T	uc010fgb.2	+	11	1937	c.1800A>T	c.(1798-1800)ATA>ATT	p.I600I	DNAH6_uc002soo.2_Silent_p.I179I|DNAH6_uc002sop.2_Silent_p.I179I	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	600	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1																		---	---	---	---	capture		Silent	SNP	84785056	84785056	4788	2	A	T	T	13	13	DNAH6	T	4	4
INPP4A	3631	broad.mit.edu	37	2	99181196	99181196	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99181196G>T	uc002syy.2	+	20	2530	c.2137G>T	c.(2137-2139)GCC>TCC	p.A713S	INPP4A_uc010yvj.1_Missense_Mutation_p.A674S|INPP4A_uc010yvk.1_Missense_Mutation_p.A674S|INPP4A_uc002syx.2_Missense_Mutation_p.A708S|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	713					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	99181196	99181196	8053	2	G	T	T	42	42	INPP4A	T	2	2
CNTNAP5	129684	broad.mit.edu	37	2	125521621	125521621	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:125521621G>T	uc002tno.2	+	16	2791	c.2427G>T	c.(2425-2427)GCG>GCT	p.A809A	CNTNAP5_uc010flu.2_Silent_p.A810A	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	809	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)														---	---	---	---	capture		Silent	SNP	125521621	125521621	3788	2	G	T	T	39	39	CNTNAP5	T	1	1
POTEE	445582	broad.mit.edu	37	2	131976296	131976296	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:131976296C>A	uc002tsn.2	+	1	373	c.321C>A	c.(319-321)CCC>CCA	p.P107P	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Translation_Start_Site|POTEE_uc002tsl.2_Translation_Start_Site	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	107							ATP binding				0																		---	---	---	---	capture		Silent	SNP	131976296	131976296	12694	2	C	A	A	24	24	POTEE	A	2	2
YSK4	80122	broad.mit.edu	37	2	135745250	135745250	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:135745250G>T	uc002tue.1	-	7	1223	c.1192C>A	c.(1192-1194)CAG>AAG	p.Q398K	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.Q285K|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.Q126K|YSK4_uc002tui.3_Missense_Mutation_p.Q415K	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	398							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)														---	---	---	---	capture		Missense_Mutation	SNP	135745250	135745250	18078	2	G	T	T	47	47	YSK4	T	2	2
MBD5	55777	broad.mit.edu	37	2	149247363	149247363	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149247363G>T	uc002twm.3	+	12	4451	c.3463G>T	c.(3463-3465)GAT>TAT	p.D1155Y	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.D1155Y|MBD5_uc002two.2_Missense_Mutation_p.D413Y|MBD5_uc002twp.2_Missense_Mutation_p.D205Y	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1155						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)														---	---	---	---	capture		Missense_Mutation	SNP	149247363	149247363	9735	2	G	T	T	45	45	MBD5	T	2	2
STAM2	10254	broad.mit.edu	37	2	152977290	152977290	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152977290G>T	uc002tyc.3	-	14	1726	c.1376C>A	c.(1375-1377)CCT>CAT	p.P459H		NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	459					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)														---	---	---	---	capture		Missense_Mutation	SNP	152977290	152977290	15768	2	G	T	T	35	35	STAM2	T	2	2
NR4A2	4929	broad.mit.edu	37	2	157182348	157182348	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:157182348C>A	uc002tyz.3	-	8	2127	c.1705G>T	c.(1705-1707)GGG>TGG	p.G569W	NR4A2_uc002tyx.3_Missense_Mutation_p.G506W|NR4A2_uc010zcf.1_Missense_Mutation_p.G569W	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	569					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3																		---	---	---	---	capture		Missense_Mutation	SNP	157182348	157182348	11038	2	C	A	A	22	22	NR4A2	A	2	2
SCN1A	6323	broad.mit.edu	37	2	166897952	166897952	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166897952G>A	uc010zcz.1	-	13	2189	c.2171C>T	c.(2170-2172)CCA>CTA	p.P724L	SCN1A_uc002udo.3_Missense_Mutation_p.P604L|SCN1A_uc010fpk.2_Missense_Mutation_p.P576L	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	735						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)													---	---	---	---	capture		Missense_Mutation	SNP	166897952	166897952	14396	2	G	A	A	47	47	SCN1A	A	2	2
XIRP2	129446	broad.mit.edu	37	2	167760268	167760268	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:167760268G>T	uc002udx.2	+	1	294	c.276G>T	c.(274-276)CGG>CGT	p.R92R	XIRP2_uc010fpn.2_Silent_p.R92R|XIRP2_uc010fpo.2_Silent_p.R92R|XIRP2_uc010fpp.2_Silent_p.R92R	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---	capture		Silent	SNP	167760268	167760268	18011	2	G	T	T	42	42	XIRP2	T	2	2
XIRP2	129446	broad.mit.edu	37	2	168103133	168103133	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168103133A>T	uc002udx.2	+	8	5249	c.5231A>T	c.(5230-5232)CAG>CTG	p.Q1744L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.Q1569L|XIRP2_uc010fpq.2_Missense_Mutation_p.Q1522L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1569					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---	capture		Missense_Mutation	SNP	168103133	168103133	18011	2	A	T	T	7	7	XIRP2	T	4	4
XIRP2	129446	broad.mit.edu	37	2	168106057	168106057	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168106057G>C	uc002udx.2	+	8	8173	c.8155G>C	c.(8155-8157)GAT>CAT	p.D2719H	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D2544H|XIRP2_uc010fpq.2_Missense_Mutation_p.D2497H|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.D65H	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2544					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---	capture		Missense_Mutation	SNP	168106057	168106057	18011	2	G	C	C	33	33	XIRP2	C	3	3
LRP2	4036	broad.mit.edu	37	2	170042267	170042267	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170042267G>A	uc002ues.2	-	50	9804	c.9591C>T	c.(9589-9591)ATC>ATT	p.I3197I		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3197	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---	capture		Silent	SNP	170042267	170042267	9329	2	G	A	A	37	37	LRP2	A	1	1
TTN	7273	broad.mit.edu	37	2	179450030	179450030	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179450030C>A	uc010zfg.1	-	258	56961	c.56737G>T	c.(56737-56739)GGG>TGG	p.G18913W	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G12608W|TTN_uc010zfi.1_Missense_Mutation_p.G12541W|TTN_uc010zfj.1_Missense_Mutation_p.G12416W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19840							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---	capture		Missense_Mutation	SNP	179450030	179450030	17290	2	C	A	A	21	21	TTN	A	2	2
TTN	7273	broad.mit.edu	37	2	179454475	179454475	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179454475G>T	uc010zfg.1	-	253	54497	c.54273C>A	c.(54271-54273)CCC>CCA	p.P18091P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.P11786P|TTN_uc010zfi.1_Silent_p.P11719P|TTN_uc010zfj.1_Silent_p.P11594P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19018							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---	capture		Silent	SNP	179454475	179454475	17290	2	G	T	T	47	47	TTN	T	2	2
TTN	7273	broad.mit.edu	37	2	179474985	179474985	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179474985C>A	uc010zfg.1	-	220	43788	c.43564G>T	c.(43564-43566)GGG>TGG	p.G14522W	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G8217W|TTN_uc010zfi.1_Missense_Mutation_p.G8150W|TTN_uc010zfj.1_Missense_Mutation_p.G8025W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15449							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---	capture		Missense_Mutation	SNP	179474985	179474985	17290	2	C	A	A	21	21	TTN	A	2	2
TTN	7273	broad.mit.edu	37	2	179636118	179636118	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179636118G>A	uc010zfg.1	-	34	8160	c.7936C>T	c.(7936-7938)CCA>TCA	p.P2646S	TTN_uc010zfh.1_Missense_Mutation_p.P2600S|TTN_uc010zfi.1_Missense_Mutation_p.P2600S|TTN_uc010zfj.1_Missense_Mutation_p.P2600S|TTN_uc002unb.2_Missense_Mutation_p.P2646S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2646							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---	capture		Missense_Mutation	SNP	179636118	179636118	17290	2	G	A	A	43	43	TTN	A	2	2
NDUFS1	4719	broad.mit.edu	37	2	207008770	207008770	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207008770T>A	uc002vbe.2	-	10	1086	c.959A>T	c.(958-960)GAG>GTG	p.E320V	NDUFS1_uc010ziq.1_Missense_Mutation_p.E334V|NDUFS1_uc010zir.1_Missense_Mutation_p.E284V|NDUFS1_uc010zis.1_Missense_Mutation_p.E263V|NDUFS1_uc010zit.1_Missense_Mutation_p.E209V|NDUFS1_uc010ziu.1_Missense_Mutation_p.E204V	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	320					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)													---	---	---	---	capture		Missense_Mutation	SNP	207008770	207008770	10690	2	T	A	A	54	54	NDUFS1	A	4	4
IQCA1	79781	broad.mit.edu	37	2	237300976	237300976	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:237300976C>A	uc002vvz.1	-	10	1410	c.1228G>T	c.(1228-1230)GAT>TAT	p.D410Y	IQCA1_uc002vwb.2_Missense_Mutation_p.D417Y|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.D369Y	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	410	Lys-rich.						ATP binding			ovary(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	237300976	237300976	8103	2	C	A	A	32	32	IQCA1	A	2	2
C2orf85	285093	broad.mit.edu	37	2	242814655	242814655	+	Silent	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242814655C>G	uc010fzu.1	+	2	971	c.948C>G	c.(946-948)GTC>GTG	p.V316V		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	316						integral to membrane				ovary(1)	1																		---	---	---	---	capture		Silent	SNP	242814655	242814655	2292	2	C	G	G	30	30	C2orf85	G	3	3
ATRN	8455	broad.mit.edu	37	20	3578558	3578558	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3578558C>G	uc002wim.2	+	22	3565	c.3475C>G	c.(3475-3477)CTT>GTT	p.L1159V	ATRN_uc002wil.2_Missense_Mutation_p.L1159V	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1159	Extracellular (Potential).				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2																		---	---	---	---	capture		Missense_Mutation	SNP	3578558	3578558	1225	20	C	G	G	32	32	ATRN	G	3	3
C20orf30	29058	broad.mit.edu	37	20	5086887	5086887	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5086887C>A	uc002wll.2	-	4	635	c.169G>T	c.(169-171)GCC>TCC	p.A57S	C20orf30_uc010gbi.2_Missense_Mutation_p.A57S|C20orf30_uc002wlk.2_Missense_Mutation_p.A120S|C20orf30_uc002wlm.2_Missense_Mutation_p.A57S|C20orf30_uc002wln.2_Missense_Mutation_p.A57S|C20orf30_uc002wlo.2_Intron	NM_001009924	NP_001009924	Q96A57	CT030_HUMAN	hypothetical protein LOC29058 isoform 2	57	Helical; (Potential).					integral to membrane					0																		---	---	---	---	capture		Missense_Mutation	SNP	5086887	5086887	2190	20	C	A	A	27	27	C20orf30	A	1	1
ESF1	51575	broad.mit.edu	37	20	13763342	13763342	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13763342C>T	uc002woj.2	-	2	553	c.445G>A	c.(445-447)GAT>AAT	p.D149N	ESF1_uc002wok.1_Missense_Mutation_p.D149N|C20orf7_uc002wol.1_5'Flank|C20orf7_uc002wom.2_5'Flank|C20orf7_uc002won.2_5'Flank|C20orf7_uc002woo.2_5'Flank	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	149	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	13763342	13763342	5444	20	C	T	T	32	32	ESF1	T	2	2
BFSP1	631	broad.mit.edu	37	20	17492636	17492636	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:17492636C>A	uc002wpo.2	-	4	651	c.612G>T	c.(610-612)ACG>ACT	p.T204T	BFSP1_uc002wpp.2_Silent_p.T79T|BFSP1_uc010zrn.1_Silent_p.T65T|BFSP1_uc010zro.1_Silent_p.T65T	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	204	Rod.|Coil 2.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1																		---	---	---	---	capture		Silent	SNP	17492636	17492636	1439	20	C	A	A	31	31	BFSP1	A	1	1
PLCG1	5335	broad.mit.edu	37	20	39791871	39791871	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:39791871G>A	uc002xjp.1	+	8	866	c.745G>A	c.(745-747)GTG>ATG	p.V249M	PLCG1_uc002xjo.1_Missense_Mutation_p.V249M|PLCG1_uc010zwe.1_5'Flank|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	249					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)																---	---	---	---	capture		Missense_Mutation	SNP	39791871	39791871	12461	20	G	A	A	36	36	PLCG1	A	2	2
DIDO1	11083	broad.mit.edu	37	20	61511762	61511762	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61511762T>A	uc002ydr.1	-	16	5810	c.5546A>T	c.(5545-5547)CAT>CTT	p.H1849L	DIDO1_uc002yds.1_Missense_Mutation_p.H1849L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1849	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)																	---	---	---	---	capture		Missense_Mutation	SNP	61511762	61511762	4701	20	T	A	A	51	51	DIDO1	A	4	4
COL20A1	57642	broad.mit.edu	37	20	61939423	61939423	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61939423G>T	uc011aau.1	+	7	856	c.756G>T	c.(754-756)AAG>AAT	p.K252N	COL20A1_uc011aav.1_Missense_Mutation_p.K73N	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	252	VWFA.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)																	---	---	---	---	capture		Missense_Mutation	SNP	61939423	61939423	3817	20	G	T	T	35	35	COL20A1	T	2	2
DNAJC5	80331	broad.mit.edu	37	20	62559735	62559735	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62559735G>T	uc002yhf.2	+	2	207	c.37G>T	c.(37-39)GGG>TGG	p.G13W	DNAJC5_uc002yhg.1_Missense_Mutation_p.G13W|DNAJC5_uc002yhh.2_RNA	NM_025219	NP_079495	Q9H3Z4	DNJC5_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	13	J.				neurotransmitter secretion|protein folding	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|melanosome|plasma membrane	heat shock protein binding|unfolded protein binding			pancreas(1)	1	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)																	---	---	---	---	capture		Missense_Mutation	SNP	62559735	62559735	4833	20	G	T	T	47	47	DNAJC5	T	2	2
KRTAP19-7	337974	broad.mit.edu	37	21	31933554	31933554	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:31933554C>A	uc011adb.1	-	1	55	c.55G>T	c.(55-57)GGT>TGT	p.G19C		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	19						intermediate filament					0																		---	---	---	---	capture		Missense_Mutation	SNP	31933554	31933554	8849	21	C	A	A	23	23	KRTAP19-7	A	1	1
CLIC6	54102	broad.mit.edu	37	21	36079604	36079604	+	Silent	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:36079604A>T	uc010gmt.1	+	3	1455	c.1455A>T	c.(1453-1455)GGA>GGT	p.G485G	CLIC6_uc002yuf.1_Silent_p.G467G	NM_053277	NP_444507	Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	485						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---	capture		Silent	SNP	36079604	36079604	3668	21	A	T	T	9	9	CLIC6	T	4	4
PFKL	5211	broad.mit.edu	37	21	45732984	45732984	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45732984G>T	uc002zel.2	+	5	610	c.551G>T	c.(550-552)CGC>CTC	p.R184L	PFKL_uc002zek.2_Missense_Mutation_p.R231L|PFKL_uc011afd.1_Missense_Mutation_p.R231L	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	184					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)														---	---	---	---	capture		Missense_Mutation	SNP	45732984	45732984	12186	21	G	T	T	38	38	PFKL	T	1	1
KRTAP10-4	386672	broad.mit.edu	37	21	45994758	45994758	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45994758G>T	uc002zfk.1	+	1	1153	c.1123G>T	c.(1123-1125)GTG>TTG	p.V375L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	375	36 X 5 AA repeats of C-C-X(3).|35.					keratin filament					0																		---	---	---	---	capture		Missense_Mutation	SNP	45994758	45994758	8826	21	G	T	T	40	40	KRTAP10-4	T	1	1
SLC5A1	6523	broad.mit.edu	37	22	32487631	32487631	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32487631G>T	uc003amc.2	+	11	1394	c.1162G>T	c.(1162-1164)GCC>TCC	p.A388S	SLC5A1_uc011alz.1_Missense_Mutation_p.A261S	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	388	Helical; (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	32487631	32487631	15158	22	G	T	T	42	42	SLC5A1	T	2	2
SYN3	8224	broad.mit.edu	37	22	33376671	33376671	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:33376671C>A	uc003amx.2	-	2	487	c.328G>T	c.(328-330)GGG>TGG	p.G110W	SYN3_uc003amy.2_Missense_Mutation_p.G110W|SYN3_uc003amz.2_Missense_Mutation_p.G110W	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	110	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	33376671	33376671	15963	22	C	A	A	21	21	SYN3	A	2	2
MCHR1	2847	broad.mit.edu	37	22	41077580	41077580	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41077580C>T	uc003ayz.2	+	2	1185	c.917C>T	c.(916-918)TCC>TTC	p.S306F	MCHR1_uc003aza.2_Missense_Mutation_p.S195F|uc003azb.1_RNA	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	306	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0																		---	---	---	---	capture		Missense_Mutation	SNP	41077580	41077580	9771	22	C	T	T	30	30	MCHR1	T	2	2
WNT7B	7477	broad.mit.edu	37	22	46327059	46327059	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46327059G>T	uc003bgo.2	-	3	863	c.489C>A	c.(487-489)TCC>TCA	p.S163S	WNT7B_uc010haa.2_Silent_p.S167S	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	163					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---	capture		Silent	SNP	46327059	46327059	17969	22	G	T	T	43	43	WNT7B	T	2	2
NICN1	84276	broad.mit.edu	37	3	49462440	49462440	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49462440C>A	uc003cwz.1	-	5	627	c.542G>T	c.(541-543)TGG>TTG	p.W181L	AMT_uc011bcn.1_5'Flank|AMT_uc003cww.2_5'Flank|AMT_uc003cwx.2_5'Flank|AMT_uc011bco.1_5'Flank|AMT_uc003cwy.2_5'Flank|AMT_uc011bcp.1_5'Flank|AMT_uc011bcq.1_5'Flank|NICN1_uc003cxa.2_RNA|NICN1_uc011bcr.1_Missense_Mutation_p.W143L	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	181						microtubule|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)														---	---	---	---	capture		Missense_Mutation	SNP	49462440	49462440	10814	3	C	A	A	21	21	NICN1	A	2	2
CACNA2D2	9254	broad.mit.edu	37	3	50402790	50402790	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50402790G>A	uc003daq.2	-	36	3154	c.3116C>T	c.(3115-3117)TCC>TTC	p.S1039F	CACNA2D2_uc003dap.2_Missense_Mutation_p.S1032F|CACNA2D2_uc003dao.2_Silent_p.L77L	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	1039	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)													---	---	---	---	capture		Missense_Mutation	SNP	50402790	50402790	2665	3	G	A	A	41	41	CACNA2D2	A	2	2
CADPS	8618	broad.mit.edu	37	3	62522231	62522231	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:62522231G>A	uc003dll.2	-	12	2352	c.1992C>T	c.(1990-1992)GGC>GGT	p.G664G	CADPS_uc003dlk.1_Silent_p.G168G|CADPS_uc003dlm.2_Silent_p.G664G|CADPS_uc003dln.2_Silent_p.G664G	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	664					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)														---	---	---	---	capture		Silent	SNP	62522231	62522231	2686	3	G	A	A	46	46	CADPS	A	2	2
ABI3BP	25890	broad.mit.edu	37	3	100594368	100594368	+	Silent	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100594368C>G	uc003dun.2	-	8	907	c.822G>C	c.(820-822)CTG>CTC	p.L274L	ABI3BP_uc003duo.2_Silent_p.L267L|ABI3BP_uc003dup.3_Silent_p.L267L	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	274						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4																		---	---	---	---	capture		Silent	SNP	100594368	100594368	92	3	C	G	G	21	21	ABI3BP	G	3	3
MYH15	22989	broad.mit.edu	37	3	108211976	108211976	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108211976C>G	uc003dxa.1	-	9	877	c.820G>C	c.(820-822)GTG>CTG	p.V274L		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	274	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7																		---	---	---	---	capture		Missense_Mutation	SNP	108211976	108211976	10429	3	C	G	G	17	17	MYH15	G	3	3
EEFSEC	60678	broad.mit.edu	37	3	127965812	127965812	+	Silent	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:127965812C>G	uc003eki.2	+	2	488	c.450C>G	c.(448-450)CTC>CTG	p.L150L	EEFSEC_uc003ekj.2_Silent_p.L150L	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	150	GTP (Potential).					cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1																		---	---	---	---	capture		Silent	SNP	127965812	127965812	5118	3	C	G	G	32	32	EEFSEC	G	3	3
EPHB1	2047	broad.mit.edu	37	3	134959993	134959993	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:134959993G>T	uc003eqt.2	+	13	2570	c.2350G>T	c.(2350-2352)GGG>TGG	p.G784W	EPHB1_uc003equ.2_Missense_Mutation_p.G345W	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	784	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30																		---	---	---	---	capture		Missense_Mutation	SNP	134959993	134959993	5367	3	G	T	T	35	35	EPHB1	T	2	2
PCCB	5096	broad.mit.edu	37	3	136035861	136035861	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:136035861G>T	uc003eqy.1	+	10	1096	c.1045G>T	c.(1045-1047)GGG>TGG	p.G349W	PCCB_uc003eqz.1_Missense_Mutation_p.G349W|PCCB_uc011bmc.1_Missense_Mutation_p.G369W|PCCB_uc011bmd.1_Missense_Mutation_p.G266W	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	349	Acyl-CoA binding (Potential).|Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)													---	---	---	---	capture		Missense_Mutation	SNP	136035861	136035861	11925	3	G	T	T	47	47	PCCB	T	2	2
AGTR1	185	broad.mit.edu	37	3	148459456	148459456	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148459456C>A	uc003ewg.2	+	4	1080	c.634C>A	c.(634-636)CTT>ATT	p.L212I	AGTR1_uc003ewh.2_Missense_Mutation_p.L212I|AGTR1_uc003ewi.2_Missense_Mutation_p.L212I|AGTR1_uc003ewj.2_Missense_Mutation_p.L212I|AGTR1_uc003ewk.2_Missense_Mutation_p.L212I	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	212	Helical; Name=5; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)													---	---	---	---	capture		Missense_Mutation	SNP	148459456	148459456	404	3	C	A	A	32	32	AGTR1	A	2	2
IGSF10	285313	broad.mit.edu	37	3	151164451	151164451	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151164451G>T	uc011bod.1	-	4	3318	c.3318C>A	c.(3316-3318)GTC>GTA	p.V1106V		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1106					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---	capture		Silent	SNP	151164451	151164451	7898	3	G	T	T	41	41	IGSF10	T	2	2
GPR149	344758	broad.mit.edu	37	3	154055904	154055904	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154055904A>T	uc003faa.2	-	4	1880	c.1780T>A	c.(1780-1782)TCC>ACC	p.S594T		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	594	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---	capture		Missense_Mutation	SNP	154055904	154055904	6929	3	A	T	T	12	12	GPR149	T	4	4
PLCH1	23007	broad.mit.edu	37	3	155203419	155203419	+	Silent	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155203419T>C	uc011bok.1	-	22	3001	c.2724A>G	c.(2722-2724)GTA>GTG	p.V908V	PLCH1_uc011boj.1_Silent_p.V908V|PLCH1_uc011bol.1_Silent_p.V870V	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	908					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---	capture		Silent	SNP	155203419	155203419	12463	3	T	C	C	57	57	PLCH1	C	4	4
SLC33A1	9197	broad.mit.edu	37	3	155571626	155571626	+	Missense_Mutation	SNP	C	A	A	rs147450168		TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155571626C>A	uc003fan.3	-	1	542	c.161G>T	c.(160-162)GGG>GTG	p.G54V	SLC33A1_uc003fao.1_Missense_Mutation_p.G54V	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	54	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---	capture		Missense_Mutation	SNP	155571626	155571626	15063	3	C	A	A	22	22	SLC33A1	A	2	2
SI	6476	broad.mit.edu	37	3	164709160	164709160	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:164709160C>A	uc003fei.2	-	44	5151	c.5089G>T	c.(5089-5091)GCT>TCT	p.A1697S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1697	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)										HNSCC(35;0.089)			---	---	---	---	capture		Missense_Mutation	SNP	164709160	164709160	14792	3	C	A	A	28	28	SI	A	2	2
SLITRK3	22865	broad.mit.edu	37	3	164905994	164905994	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:164905994C>A	uc003fej.3	-	2	3069	c.2625G>T	c.(2623-2625)GGG>GGT	p.G875G	SLITRK3_uc003fek.2_Silent_p.G875G	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	875	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10															HNSCC(40;0.11)			---	---	---	---	capture		Silent	SNP	164905994	164905994	15242	3	C	A	A	22	22	SLITRK3	A	2	2
PLD1	5337	broad.mit.edu	37	3	171320967	171320967	+	Silent	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:171320967T>C	uc003fhs.2	-	27	3242	c.3126A>G	c.(3124-3126)GGA>GGG	p.G1042G	PLD1_uc003fht.2_Silent_p.G1004G	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	1042					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)													---	---	---	---	capture		Silent	SNP	171320967	171320967	12471	3	T	C	C	50	50	PLD1	C	4	4
FNDC3B	64778	broad.mit.edu	37	3	172025152	172025152	+	Splice_Site	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172025152G>T	uc003fhy.2	+	10	1234	c.1062_splice	c.e10-1	p.R354_splice	FNDC3B_uc003fhz.3_Splice_Site_p.R354_splice|FNDC3B_uc003fia.2_Splice_Site_p.R285_splice	NM_022763	NP_073600			fibronectin type III domain containing 3B							endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)														---	---	---	---	capture		Splice_Site	SNP	172025152	172025152	6212	3	G	T	T	35	35	FNDC3B	T	5	2
NDUFB5	4711	broad.mit.edu	37	3	179322629	179322629	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179322629G>C	uc003fkc.2	+	1	55	c.26G>C	c.(25-27)CGG>CCG	p.R9P	MRPL47_uc003fjz.2_5'Flank|MRPL47_uc003fka.2_5'Flank|MRPL47_uc003fkb.2_5'Flank|NDUFB5_uc003fkd.2_RNA|NDUFB5_uc003fke.2_Missense_Mutation_p.R9P	NM_002492	NP_002483	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	9					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			skin(1)	1	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)													---	---	---	---	capture		Missense_Mutation	SNP	179322629	179322629	10683	3	G	C	C	39	39	NDUFB5	C	3	3
ATP13A3	79572	broad.mit.edu	37	3	194167745	194167745	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194167745G>C	uc003fty.3	-	13	1810	c.1408C>G	c.(1408-1410)CAG>GAG	p.Q470E	ATP13A3_uc003ftz.1_Missense_Mutation_p.Q176E	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	470					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)														---	---	---	---	capture		Missense_Mutation	SNP	194167745	194167745	1144	3	G	C	C	45	45	ATP13A3	C	3	3
MUC4	4585	broad.mit.edu	37	3	195518138	195518138	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195518138G>T	uc011bto.1	-	2	773	c.313C>A	c.(313-315)CCA>ACA	p.P105T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_5'Flank	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	105					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)														---	---	---	---	capture		Missense_Mutation	SNP	195518138	195518138	10372	3	G	T	T	43	43	MUC4	T	2	2
BDH1	622	broad.mit.edu	37	3	197260416	197260416	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197260416C>A	uc003fxr.2	-	4	502	c.100G>T	c.(100-102)GGT>TGT	p.G34C	BDH1_uc003fxs.2_Missense_Mutation_p.G34C|BDH1_uc003fxt.2_5'UTR|BDH1_uc003fxu.2_Missense_Mutation_p.G34C	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	34					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)													---	---	---	---	capture		Missense_Mutation	SNP	197260416	197260416	1412	3	C	A	A	21	21	BDH1	A	2	2
EVC2	132884	broad.mit.edu	37	4	5687126	5687126	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5687126C>A	uc003gij.2	-	6	841	c.787G>T	c.(787-789)GCC>TCC	p.A263S	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.A183S	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	263						integral to membrane				large_intestine(3)|ovary(2)	5																		---	---	---	---	capture		Missense_Mutation	SNP	5687126	5687126	5479	4	C	A	A	25	25	EVC2	A	2	2
CPZ	8532	broad.mit.edu	37	4	8613863	8613863	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8613863G>T	uc003glm.2	+	8	1463	c.1337G>T	c.(1336-1338)GGG>GTG	p.G446V	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.G309V|CPZ_uc003glo.2_Missense_Mutation_p.G435V|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	446					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	8613863	8613863	3978	4	G	T	T	43	43	CPZ	T	2	2
BST1	683	broad.mit.edu	37	4	15716916	15716916	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15716916G>T	uc003goh.3	+	5	738	c.543G>T	c.(541-543)AAG>AAT	p.K181N	BST1_uc003goi.2_Translation_Start_Site	NM_004334	NP_004325	Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1 precursor	181					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	15716916	15716916	1565	4	G	T	T	35	35	BST1	T	2	2
PCDH10	57575	broad.mit.edu	37	4	134072866	134072866	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:134072866A>G	uc003iha.2	+	1	2397	c.1571A>G	c.(1570-1572)TAC>TGC	p.Y524C	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.Y524C	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	524	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)														---	---	---	---	capture		Missense_Mutation	SNP	134072866	134072866	11927	4	A	G	G	14	14	PCDH10	G	4	4
TBC1D9	23158	broad.mit.edu	37	4	141600878	141600878	+	Silent	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:141600878G>C	uc010ioj.2	-	4	752	c.480C>G	c.(478-480)CTC>CTG	p.L160L		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	160	GRAM 1.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)																---	---	---	---	capture		Silent	SNP	141600878	141600878	16153	4	G	C	C	37	37	TBC1D9	C	3	3
RNF150	57484	broad.mit.edu	37	4	141888789	141888789	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:141888789C>G	uc003iio.1	-	2	1377	c.723G>C	c.(721-723)AGG>AGC	p.R241S	RNF150_uc010iok.1_Intron|RNF150_uc003iip.1_Missense_Mutation_p.R241S	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	241	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)																	---	---	---	---	capture		Missense_Mutation	SNP	141888789	141888789	13928	4	C	G	G	22	22	RNF150	G	3	3
HHIP	64399	broad.mit.edu	37	4	145655962	145655962	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:145655962G>T	uc003ijs.1	+	12	2485	c.1830G>T	c.(1828-1830)AGG>AGT	p.R610S		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	610	EGF-like 1.					cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)														---	---	---	---	capture		Missense_Mutation	SNP	145655962	145655962	7376	4	G	T	T	42	42	HHIP	T	2	2
ABCE1	6059	broad.mit.edu	37	4	146026771	146026771	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146026771G>C	uc003ijx.2	+	3	558	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	ABCE1_uc003ijy.2_Missense_Mutation_p.E40Q|ABCE1_uc010iot.2_RNA	NM_001040876	NP_001035809	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E, member 1	40					interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			skin(1)	1	all_hematologic(180;0.151)																	---	---	---	---	capture		Missense_Mutation	SNP	146026771	146026771	65	4	G	C	C	33	33	ABCE1	C	3	3
KIAA0922	23240	broad.mit.edu	37	4	154512253	154512253	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154512253G>T	uc003inm.3	+	17	1768	c.1716G>T	c.(1714-1716)AAG>AAT	p.K572N	KIAA0922_uc010ipp.2_Missense_Mutation_p.K573N|KIAA0922_uc010ipq.2_Intron	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	572	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)																---	---	---	---	capture		Missense_Mutation	SNP	154512253	154512253	8508	4	G	T	T	35	35	KIAA0922	T	2	2
TDO2	6999	broad.mit.edu	37	4	156831260	156831260	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156831260G>C	uc003ipf.1	+	6	579	c.515G>C	c.(514-516)AGA>ACA	p.R172T		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	172					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)													---	---	---	---	capture		Missense_Mutation	SNP	156831260	156831260	16253	4	G	C	C	33	33	TDO2	C	3	3
DDX60L	91351	broad.mit.edu	37	4	169342912	169342912	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169342912T>A	uc003irq.3	-	17	2614	c.2393A>T	c.(2392-2394)AAG>ATG	p.K798M	DDX60L_uc003irr.1_Missense_Mutation_p.K798M|DDX60L_uc003irs.1_Missense_Mutation_p.K525M	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	798	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)														---	---	---	---	capture		Missense_Mutation	SNP	169342912	169342912	4550	4	T	A	A	56	56	DDX60L	A	4	4
WWC2	80014	broad.mit.edu	37	4	184186236	184186236	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184186236G>T	uc010irx.2	+	12	2197	c.2015G>T	c.(2014-2016)GGG>GTG	p.G672V	WWC2_uc003ivk.3_Missense_Mutation_p.G467V|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.G354V|WWC2_uc003ivn.3_Missense_Mutation_p.G187V|WWC2_uc010irz.2_5'Flank	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	672										ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)														---	---	---	---	capture		Missense_Mutation	SNP	184186236	184186236	17986	4	G	T	T	43	43	WWC2	T	2	2
SDHA	6389	broad.mit.edu	37	5	226069	226069	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:226069G>C	uc003jao.3	+	5	643	c.528G>C	c.(526-528)CAG>CAC	p.Q176H	SDHA_uc003jan.2_Missense_Mutation_p.Q176H|SDHA_uc011clv.1_Missense_Mutation_p.Q176H|SDHA_uc011clw.1_Missense_Mutation_p.Q128H|SDHA_uc003jap.3_Missense_Mutation_p.Q176H|SDHA_uc003jaq.3_5'Flank	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	176					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)									Familial_Paragangliomas				---	---	---	---	capture		Missense_Mutation	SNP	226069	226069	14448	5	G	C	C	33	33	SDHA	C	3	3
SLC6A3	6531	broad.mit.edu	37	5	1432761	1432761	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1432761G>A	uc003jck.2	-	4	592	c.471C>T	c.(469-471)AAC>AAT	p.N157N		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	157	Helical; Name=3; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)													---	---	---	---	capture		Silent	SNP	1432761	1432761	15182	5	G	A	A	40	40	SLC6A3	A	1	1
SEMA5A	9037	broad.mit.edu	37	5	9154614	9154614	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:9154614G>A	uc003jek.2	-	12	2179	c.1467C>T	c.(1465-1467)TTC>TTT	p.F489F		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	489	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---	capture		Silent	SNP	9154614	9154614	14523	5	G	A	A	33	33	SEMA5A	A	2	2
DNAH5	1767	broad.mit.edu	37	5	13721281	13721281	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13721281C>A	uc003jfd.2	-	71	12149	c.12107G>T	c.(12106-12108)TGG>TTG	p.W4036L	DNAH5_uc003jfc.2_Missense_Mutation_p.W204L	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4036	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---	capture		Missense_Mutation	SNP	13721281	13721281	4787	5	C	A	A	21	21	DNAH5	A	2	2
PRLR	5618	broad.mit.edu	37	5	35086375	35086375	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35086375G>T	uc003jjm.2	-	4	668	c.138C>A	c.(136-138)TGC>TGA	p.C46*	PRLR_uc003jjg.1_Nonsense_Mutation_p.C46*|PRLR_uc003jjh.1_Nonsense_Mutation_p.C46*|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Nonsense_Mutation_p.C46*|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_Translation_Start_Site	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	46	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)													---	---	---	---	capture		Nonsense_Mutation	SNP	35086375	35086375	12974	5	G	T	T	34	34	PRLR	T	5	2
HTR1A	3350	broad.mit.edu	37	5	63256881	63256881	+	Silent	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:63256881C>G	uc011cqt.1	-	1	666	c.666G>C	c.(664-666)GCG>GCC	p.A222A		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	222	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)													---	---	---	---	capture		Silent	SNP	63256881	63256881	7736	5	C	G	G	27	27	HTR1A	G	3	3
BDP1	55814	broad.mit.edu	37	5	70840961	70840961	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:70840961A>T	uc003kbp.1	+	32	6922	c.6659A>T	c.(6658-6660)GAT>GTT	p.D2220V	BDP1_uc003kbo.2_Missense_Mutation_p.D2220V|BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2220					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)														---	---	---	---	capture		Missense_Mutation	SNP	70840961	70840961	1417	5	A	T	T	12	12	BDP1	T	4	4
THBS4	7060	broad.mit.edu	37	5	79368174	79368174	+	Silent	SNP	G	T	T	rs141977601	byFrequency	TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79368174G>T	uc003kgh.2	+	15	2117	c.1794G>T	c.(1792-1794)GTG>GTT	p.V598V	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	598	TSP type-3 5.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)														---	---	---	---	capture		Silent	SNP	79368174	79368174	16384	5	G	T	T	47	47	THBS4	T	2	2
CAMK4	814	broad.mit.edu	37	5	110809012	110809012	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110809012C>A	uc011cvj.1	+	9	728	c.629C>A	c.(628-630)CCT>CAT	p.P210H	CAMK4_uc003kpf.2_Missense_Mutation_p.P210H|CAMK4_uc010jbv.2_Missense_Mutation_p.P13H	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	210	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)														---	---	---	---	capture		Missense_Mutation	SNP	110809012	110809012	2722	5	C	A	A	24	24	CAMK4	A	2	2
APC	324	broad.mit.edu	37	5	112173893	112173893	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112173893G>C	uc010jby.2	+	16	2982	c.2602G>C	c.(2602-2604)GAA>CAA	p.E868Q	APC_uc011cvt.1_Missense_Mutation_p.E850Q|APC_uc003kpz.3_Missense_Mutation_p.E868Q|APC_uc003kpy.3_Missense_Mutation_p.E868Q|APC_uc010jbz.2_Missense_Mutation_p.E585Q|APC_uc010jca.2_Missense_Mutation_p.E168Q	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	868	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E868*(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)			12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---	---	capture		Missense_Mutation	SNP	112173893	112173893	773	5	G	C	C	33	33	APC	C	3	3
DMXL1	1657	broad.mit.edu	37	5	118484909	118484909	+	Silent	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118484909A>G	uc003ksd.2	+	18	3568	c.3387A>G	c.(3385-3387)AAA>AAG	p.K1129K	DMXL1_uc010jcl.1_Silent_p.K1129K	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1129										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---	capture		Silent	SNP	118484909	118484909	4776	5	A	G	G	3	3	DMXL1	G	4	4
TCF7	6932	broad.mit.edu	37	5	133478442	133478442	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133478442G>T	uc003kyt.2	+	7	982	c.786G>T	c.(784-786)AAG>AAT	p.K262N	TCF7_uc003kyu.1_Missense_Mutation_p.K147N|TCF7_uc003kyv.2_Missense_Mutation_p.K147N|TCF7_uc003kyw.2_Missense_Mutation_p.K147N|TCF7_uc003kyx.2_Missense_Mutation_p.K60N|TCF7_uc003kyy.2_Missense_Mutation_p.K147N|TCF7_uc003kyz.2_Missense_Mutation_p.K147N|TCF7_uc003kza.2_Missense_Mutation_p.K147N|TCF7_uc003kzb.2_Missense_Mutation_p.K76N|TCF7_uc010jdu.2_5'Flank	NM_003202	NP_003193	P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific,	262					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---	capture		Missense_Mutation	SNP	133478442	133478442	16222	5	G	T	T	35	35	TCF7	T	2	2
CATSPER3	347732	broad.mit.edu	37	5	134305628	134305628	+	Splice_Site	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134305628G>T	uc003lag.2	+	2	167	c.99_splice	c.e2-1	p.K33_splice		NM_178019	NP_821138			cation channel, sperm associated 3						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---	capture		Splice_Site	SNP	134305628	134305628	2808	5	G	T	T	35	35	CATSPER3	T	5	2
KDM3B	51780	broad.mit.edu	37	5	137762958	137762958	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137762958C>G	uc003lcy.1	+	19	4783	c.4583C>G	c.(4582-4584)CCT>CGT	p.P1528R	KDM3B_uc010jew.1_Missense_Mutation_p.P1184R|KDM3B_uc011cys.1_Missense_Mutation_p.P560R	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1528	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11																		---	---	---	---	capture		Missense_Mutation	SNP	137762958	137762958	8433	5	C	G	G	24	24	KDM3B	G	3	3
PCDHB5	26167	broad.mit.edu	37	5	140515987	140515987	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140515987G>T	uc003liq.2	+	1	1188	c.971G>T	c.(970-972)GGG>GTG	p.G324V		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	324	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---	capture		Missense_Mutation	SNP	140515987	140515987	11965	5	G	T	T	43	43	PCDHB5	T	2	2
PCDHB6	56130	broad.mit.edu	37	5	140531962	140531962	+	Silent	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140531962G>C	uc003lir.2	+	1	2124	c.2124G>C	c.(2122-2124)GCG>GCC	p.A708A	PCDHB6_uc011dah.1_Silent_p.A572A	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	708	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---	capture		Silent	SNP	140531962	140531962	11966	5	G	C	C	39	39	PCDHB6	C	3	3
PCDHGA5	56110	broad.mit.edu	37	5	140744848	140744848	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140744848G>T	uc003lju.1	+	1	951	c.951G>T	c.(949-951)ATG>ATT	p.M317I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.M317I	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	317	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---	capture		Missense_Mutation	SNP	140744848	140744848	11977	5	G	T	T	47	47	PCDHGA5	T	2	2
PCDHGB4	8641	broad.mit.edu	37	5	140769650	140769650	+	Silent	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140769650C>T	uc003lkc.1	+	1	2199	c.2199C>T	c.(2197-2199)TCC>TCT	p.S733S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.S733S	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	733	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---	capture		Silent	SNP	140769650	140769650	11985	5	C	T	T	23	23	PCDHGB4	T	1	1
PCDHGA10	56106	broad.mit.edu	37	5	140794536	140794536	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140794536G>A	uc003lkl.1	+	1	1794	c.1794G>A	c.(1792-1794)GTG>GTA	p.V598V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.V598V|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	598	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---	capture		Silent	SNP	140794536	140794536	11971	5	G	A	A	47	47	PCDHGA10	A	2	2
PPP2R2B	5521	broad.mit.edu	37	5	145969719	145969719	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145969719G>T	uc003loe.2	-	9	1648	c.1123C>A	c.(1123-1125)CTT>ATT	p.L375I	PPP2R2B_uc010jgm.2_Missense_Mutation_p.L364I|PPP2R2B_uc003log.3_Missense_Mutation_p.L375I|PPP2R2B_uc003lof.3_Missense_Mutation_p.L375I|PPP2R2B_uc003loi.3_Missense_Mutation_p.L378I|PPP2R2B_uc003loh.3_Missense_Mutation_p.L375I|PPP2R2B_uc003loj.3_Missense_Mutation_p.L355I|PPP2R2B_uc003lok.3_Missense_Mutation_p.L364I|PPP2R2B_uc011dbu.1_Missense_Mutation_p.L381I|PPP2R2B_uc011dbv.1_Missense_Mutation_p.L433I	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	375	WD 6.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---	capture		Missense_Mutation	SNP	145969719	145969719	12821	5	G	T	T	35	35	PPP2R2B	T	2	2
HAVCR2	84868	broad.mit.edu	37	5	156533930	156533930	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156533930G>A	uc003lwk.1	-	2	246	c.102C>T	c.(100-102)GCC>GCT	p.A34A	HAVCR2_uc003lwl.2_Silent_p.A34A	NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	34	Ig-like V-type.|Extracellular (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---	capture		Silent	SNP	156533930	156533930	7256	5	G	A	A	35	35	HAVCR2	A	2	2
PHACTR1	221692	broad.mit.edu	37	6	13182804	13182804	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13182804C>A	uc010jpc.2	+	7	882	c.550C>A	c.(550-552)CTG>ATG	p.L184M	PHACTR1_uc011dir.1_Missense_Mutation_p.L184M|PHACTR1_uc003nag.1_Missense_Mutation_p.L184M|PHACTR1_uc003nah.1_Missense_Mutation_p.L184M	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	184						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)															---	---	---	---	capture		Missense_Mutation	SNP	13182804	13182804	12232	6	C	A	A	24	24	PHACTR1	A	2	2
KIF13A	63971	broad.mit.edu	37	6	17781053	17781053	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17781053G>T	uc003ncg.3	-	31	3859	c.3754C>A	c.(3754-3756)CTA>ATA	p.L1252I	KIF13A_uc003ncf.2_Missense_Mutation_p.L1239I|KIF13A_uc003nch.3_Missense_Mutation_p.L1252I|KIF13A_uc003nci.3_Missense_Mutation_p.L1239I|KIF13A_uc003nce.1_5'Flank	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1252					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)															---	---	---	---	capture		Missense_Mutation	SNP	17781053	17781053	8585	6	G	T	T	35	35	KIF13A	T	2	2
KIF13A	63971	broad.mit.edu	37	6	17817326	17817326	+	Missense_Mutation	SNP	T	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17817326T>G	uc003ncg.3	-	17	2030	c.1925A>C	c.(1924-1926)CAG>CCG	p.Q642P	KIF13A_uc003ncf.2_Missense_Mutation_p.Q642P|KIF13A_uc003nch.3_Missense_Mutation_p.Q642P|KIF13A_uc003nci.3_Missense_Mutation_p.Q642P|KIF13A_uc003ncj.2_Missense_Mutation_p.Q318P	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	642	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)															---	---	---	---	capture		Missense_Mutation	SNP	17817326	17817326	8585	6	T	G	G	55	55	KIF13A	G	4	4
CDKAL1	54901	broad.mit.edu	37	6	20955674	20955674	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:20955674C>G	uc003ndc.1	+	10	941	c.767C>G	c.(766-768)ACC>AGC	p.T256S	CDKAL1_uc003ndd.1_Missense_Mutation_p.T256S|CDKAL1_uc003nde.1_Missense_Mutation_p.T186S	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	256					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)															---	---	---	---	capture		Missense_Mutation	SNP	20955674	20955674	3281	6	C	G	G	18	18	CDKAL1	G	3	3
GPLD1	2822	broad.mit.edu	37	6	24476472	24476472	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24476472C>A	uc003ned.1	-	4	378	c.267G>T	c.(265-267)TGG>TGT	p.W89C	GPLD1_uc010jpr.1_5'UTR|GPLD1_uc010jps.1_Missense_Mutation_p.W89C|GPLD1_uc003nee.2_Missense_Mutation_p.W89C	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	89						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	24476472	24476472	6888	6	C	A	A	30	30	GPLD1	A	2	2
HIST1H2BJ	8970	broad.mit.edu	37	6	27100230	27100230	+	Silent	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27100230G>A	uc003niv.2	-	1	346	c.300C>T	c.(298-300)CGC>CGT	p.R100R	HIST1H2BJ_uc003niu.1_Intron|HIST1H2AG_uc003niw.2_5'Flank	NM_021058	NP_066402	P06899	H2B1J_HUMAN	histone cluster 1, H2bj	100					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---	capture		Silent	SNP	27100230	27100230	7434	6	G	A	A	42	42	HIST1H2BJ	A	2	2
C6orf222	389384	broad.mit.edu	37	6	36298332	36298332	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36298332T>C	uc003oly.2	-	2	314	c.136A>G	c.(136-138)AAG>GAG	p.K46E		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	46										skin(2)|ovary(1)|breast(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	36298332	36298332	2461	6	T	C	C	62	62	C6orf222	C	4	4
GSTA4	2941	broad.mit.edu	37	6	52843315	52843315	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52843315G>T	uc003pbc.2	-	6	686	c.622C>A	c.(622-624)CCT>ACT	p.P208T	GSTA4_uc003pbd.2_Missense_Mutation_p.P115T|GSTA4_uc003pbe.2_Missense_Mutation_p.P115T|GSTA4_uc003pbf.2_Missense_Mutation_p.P208T	NM_001512	NP_001503	O15217	GSTA4_HUMAN	glutathione S-transferase alpha 4	208	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity				0	Lung NSC(77;0.103)				Glutathione(DB00143)													---	---	---	---	capture		Missense_Mutation	SNP	52843315	52843315	7113	6	G	T	T	43	43	GSTA4	T	2	2
PRIM2	5558	broad.mit.edu	37	6	57512691	57512691	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57512691G>T	uc003pdx.2	+	15	1606	c.1519G>T	c.(1519-1521)GAA>TAA	p.E507*		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	507					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)														---	---	---	---	capture		Nonsense_Mutation	SNP	57512691	57512691	12934	6	G	T	T	45	45	PRIM2	T	5	2
FUT9	10690	broad.mit.edu	37	6	96651734	96651734	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:96651734A>G	uc003pop.3	+	3	1044	c.703A>G	c.(703-705)ATA>GTA	p.I235V		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	235	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)														---	---	---	---	capture		Missense_Mutation	SNP	96651734	96651734	6362	6	A	G	G	8	8	FUT9	G	4	4
LAMA4	3910	broad.mit.edu	37	6	112452259	112452259	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112452259C>T	uc003pvu.2	-	29	4188	c.3879G>A	c.(3877-3879)ATG>ATA	p.M1293I	LAMA4_uc003pvv.2_Missense_Mutation_p.M1286I|LAMA4_uc003pvt.2_Missense_Mutation_p.M1286I	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1293	Laminin G-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding	p.M1286I(1)		ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)														---	---	---	---	capture		Missense_Mutation	SNP	112452259	112452259	8931	6	C	T	T	21	21	LAMA4	T	2	2
VNN2	8875	broad.mit.edu	37	6	133065475	133065475	+	Silent	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:133065475T>C	uc003qdt.2	-	7	1538	c.1527A>G	c.(1525-1527)TTA>TTG	p.L509L	VNN2_uc003qds.2_Silent_p.L218L|VNN2_uc010kgb.2_Silent_p.L288L|VNN2_uc003qdv.2_Silent_p.L456L	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	509					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)														---	---	---	---	capture		Silent	SNP	133065475	133065475	17750	6	T	C	C	61	61	VNN2	C	4	4
ICA1	3382	broad.mit.edu	37	7	8167536	8167536	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:8167536G>T	uc003srm.2	-	13	1364	c.1297C>A	c.(1297-1299)CAA>AAA	p.Q433K	ICA1_uc010ktr.2_Missense_Mutation_p.Q462K|ICA1_uc003srl.2_Missense_Mutation_p.Q421K|ICA1_uc003srn.3_Missense_Mutation_p.Q359K|ICA1_uc003srp.3_Missense_Mutation_p.Q432K|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.Q433K|ICA1_uc003srr.2_Missense_Mutation_p.Q432K|ICA1_uc003sro.3_Missense_Mutation_p.Q433K	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	433					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)														---	---	---	---	capture		Missense_Mutation	SNP	8167536	8167536	7777	7	G	T	T	47	47	ICA1	T	2	2
ABCB5	340273	broad.mit.edu	37	7	20682900	20682900	+	Silent	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:20682900C>A	uc010kuh.2	+	6	645	c.408C>A	c.(406-408)ACC>ACA	p.T136T		NM_001163941	NP_001157413	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	320	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6																		---	---	---	---	capture		Silent	SNP	20682900	20682900	45	7	C	A	A	21	21	ABCB5	A	2	2
HIBADH	11112	broad.mit.edu	37	7	27582650	27582650	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27582650G>T	uc003szf.2	-	5	749	c.554C>A	c.(553-555)GCC>GAC	p.A185D	HIBADH_uc003szg.2_Missense_Mutation_p.A136D|HIBADH_uc003szh.2_Missense_Mutation_p.A84D|HIBADH_uc003szi.2_Missense_Mutation_p.A136D	NM_152740	NP_689953	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase precursor	185					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			ovary(2)	2			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)													---	---	---	---	capture		Missense_Mutation	SNP	27582650	27582650	7384	7	G	T	T	42	42	HIBADH	T	2	2
TBX20	57057	broad.mit.edu	37	7	35289604	35289604	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35289604G>T	uc011kas.1	-	2	350	c.339C>A	c.(337-339)TTC>TTA	p.F113L		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	113	T-box.					nucleus	DNA binding			central_nervous_system(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	35289604	35289604	16182	7	G	T	T	41	41	TBX20	T	2	2
POU6F2	11281	broad.mit.edu	37	7	39446339	39446339	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:39446339G>T	uc003thb.1	+	6	1068	c.1026G>T	c.(1024-1026)CAG>CAT	p.Q342H		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	342	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	39446339	39446339	12715	7	G	T	T	35	35	POU6F2	T	2	2
PKD1L1	168507	broad.mit.edu	37	7	47968883	47968883	+	Silent	SNP	G	A	A	rs142684649		TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:47968883G>A	uc003tny.1	-	7	978	c.978C>T	c.(976-978)TTC>TTT	p.F326F		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	326	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11																		---	---	---	---	capture		Silent	SNP	47968883	47968883	12388	7	G	A	A	37	37	PKD1L1	A	1	1
ANKIB1	54467	broad.mit.edu	37	7	91974291	91974291	+	Splice_Site	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91974291G>A	uc003ulw.2	+	7	1373	c.997_splice	c.e7-1	p.C333_splice		NM_019004	NP_061877			ankyrin repeat and IBR domain containing 1								protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)															---	---	---	---	capture		Splice_Site	SNP	91974291	91974291	633	7	G	A	A	36	36	ANKIB1	A	5	2
MUC17	140453	broad.mit.edu	37	7	100675507	100675507	+	Silent	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100675507T>A	uc003uxp.1	+	3	863	c.810T>A	c.(808-810)CCT>CCA	p.P270P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	270	Extracellular (Potential).|59 X approximate tandem repeats.|2.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---	capture		Silent	SNP	100675507	100675507	10368	7	T	A	A	53	53	MUC17	A	4	4
MUC17	140453	broad.mit.edu	37	7	100676996	100676996	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100676996C>A	uc003uxp.1	+	3	2352	c.2299C>A	c.(2299-2301)CTT>ATT	p.L767I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	767	Extracellular (Potential).|Ser-rich.|10.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---	capture		Missense_Mutation	SNP	100676996	100676996	10368	7	C	A	A	24	24	MUC17	A	2	2
LHFPL3	375612	broad.mit.edu	37	7	103969486	103969486	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103969486G>T	uc003vce.2	+	1	383	c.259G>T	c.(259-261)GAG>TAG	p.E87*	LHFPL3_uc003vcf.2_Nonsense_Mutation_p.E87*	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	73						integral to membrane					0																		---	---	---	---	capture		Nonsense_Mutation	SNP	103969486	103969486	9092	7	G	T	T	41	41	LHFPL3	T	5	2
RINT1	60561	broad.mit.edu	37	7	105204355	105204355	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105204355G>T	uc003vda.1	+	12	2078	c.1847G>T	c.(1846-1848)AGA>ATA	p.R616I	RINT1_uc010ljj.1_Missense_Mutation_p.R191I	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	616	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	105204355	105204355	13853	7	G	T	T	33	33	RINT1	T	2	2
LAMB4	22798	broad.mit.edu	37	7	107688550	107688550	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107688550C>G	uc010ljo.1	-	28	4213	c.4129G>C	c.(4129-4131)GGA>CGA	p.G1377R	LAMB4_uc003vey.2_Missense_Mutation_p.G1377R|LAMB4_uc010ljp.1_Missense_Mutation_p.G346R	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1377	Domain alpha.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8																		---	---	---	---	capture		Missense_Mutation	SNP	107688550	107688550	8936	7	C	G	G	23	23	LAMB4	G	3	3
ZC3HAV1	56829	broad.mit.edu	37	7	138764550	138764550	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138764550G>T	uc003vun.2	-	4	1525	c.1137C>A	c.(1135-1137)CCC>CCA	p.P379P	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Silent_p.P379P	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	379					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---	capture		Silent	SNP	138764550	138764550	18163	7	G	T	T	47	47	ZC3HAV1	T	2	2
OR2A25	392138	broad.mit.edu	37	7	143771754	143771754	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143771754T>C	uc011ktx.1	+	1	442	c.442T>C	c.(442-444)TGG>CGG	p.W148R		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)																	---	---	---	---	capture		Missense_Mutation	SNP	143771754	143771754	11384	7	T	C	C	55	55	OR2A25	C	4	4
INTS9	55756	broad.mit.edu	37	8	28695255	28695255	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28695255G>T	uc003xha.2	-	5	599	c.300C>A	c.(298-300)CTC>CTA	p.L100L	INTS9_uc011lav.1_Silent_p.L76L|INTS9_uc011law.1_Silent_p.L79L|INTS9_uc011lax.1_5'UTR|INTS9_uc010lvc.2_RNA|INTS9_uc003xhb.2_Silent_p.L100L	NM_018250	NP_060720	Q9NV88	INT9_HUMAN	integrator complex subunit 9 isoform 1	100					snRNA processing	integrator complex	protein binding			central_nervous_system(1)|pancreas(1)	2		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)														---	---	---	---	capture		Silent	SNP	28695255	28695255	8086	8	G	T	T	45	45	INTS9	T	2	2
KCNU1	157855	broad.mit.edu	37	8	36693875	36693875	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:36693875C>A	uc010lvw.2	+	13	1444	c.1357C>A	c.(1357-1359)CAT>AAT	p.H453N	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	453	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)														---	---	---	---	capture		Missense_Mutation	SNP	36693875	36693875	8398	8	C	A	A	21	21	KCNU1	A	2	2
RAB11FIP1	80223	broad.mit.edu	37	8	37734976	37734976	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37734976G>T	uc003xkm.1	-	2	509	c.465C>A	c.(463-465)GCC>GCA	p.A155A	RAB11FIP1_uc010lvz.1_Silent_p.A3A|RAB11FIP1_uc003xkn.1_Silent_p.A155A|RAB11FIP1_uc003xkp.1_Silent_p.A3A	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	155					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)															---	---	---	---	capture		Silent	SNP	37734976	37734976	13352	8	G	T	T	47	47	RAB11FIP1	T	2	2
LETM2	137994	broad.mit.edu	37	8	38260109	38260109	+	Missense_Mutation	SNP	G	T	T	rs140730377	byFrequency	TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38260109G>T	uc003xlm.1	+	7	1081	c.910G>T	c.(910-912)GGG>TGG	p.G304W	LETM2_uc011lbn.1_Missense_Mutation_p.G148W|LETM2_uc003xll.1_Missense_Mutation_p.G256W|LETM2_uc003xln.1_Missense_Mutation_p.G148W|LETM2_uc003xlo.1_Missense_Mutation_p.G148W	NM_144652	NP_653253	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane	351	LETM1.|Mitochondrial matrix (Potential).					integral to membrane|mitochondrial inner membrane					0	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)															---	---	---	---	capture		Missense_Mutation	SNP	38260109	38260109	9059	8	G	T	T	35	35	LETM2	T	2	2
ADAM18	8749	broad.mit.edu	37	8	39502981	39502981	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39502981A>T	uc003xni.2	+	11	1034	c.1034A>T	c.(1033-1035)AAT>ATT	p.N345I	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.N321I	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	345	Peptidase M12B.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)															---	---	---	---	capture		Missense_Mutation	SNP	39502981	39502981	240	8	A	T	T	4	4	ADAM18	T	4	4
CHRNA6	8973	broad.mit.edu	37	8	42608341	42608341	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42608341C>G	uc003xpj.2	-	6	1512	c.1466G>C	c.(1465-1467)GGG>GCG	p.G489A	CHRNA6_uc011lcw.1_Missense_Mutation_p.G474A	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	489						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)															---	---	---	---	capture		Missense_Mutation	SNP	42608341	42608341	3521	8	C	G	G	22	22	CHRNA6	G	3	3
FNTA	2339	broad.mit.edu	37	8	42924714	42924714	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42924714C>G	uc003xps.2	+	4	466	c.418C>G	c.(418-420)CTT>GTT	p.L140V	FNTA_uc003xpt.2_Missense_Mutation_p.L49V|FNTA_uc003xpu.2_Missense_Mutation_p.L73V|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	140	PFTA 1.				cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)															---	---	---	---	capture		Missense_Mutation	SNP	42924714	42924714	6219	8	C	G	G	32	32	FNTA	G	3	3
PRKDC	5591	broad.mit.edu	37	8	48798615	48798615	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48798615C>A	uc003xqi.2	-	37	4723	c.4666G>T	c.(4666-4668)GGG>TGG	p.G1556W	PRKDC_uc003xqj.2_Missense_Mutation_p.G1556W|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1556					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---	capture		Missense_Mutation	SNP	48798615	48798615	12964	8	C	A	A	21	21	PRKDC	A	2	2
PI15	51050	broad.mit.edu	37	8	75757649	75757649	+	Silent	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75757649C>T	uc003yal.2	+	5	737	c.558C>T	c.(556-558)TGC>TGT	p.C186C	uc003yak.1_Intron|PI15_uc003yam.2_Silent_p.C186C	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	186						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)															---	---	---	---	capture		Silent	SNP	75757649	75757649	12292	8	C	T	T	27	27	PI15	T	1	1
ZFHX4	79776	broad.mit.edu	37	8	77618662	77618662	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77618662G>C	uc003yav.2	+	2	2726	c.2339G>C	c.(2338-2340)AGG>ACG	p.R780T	ZFHX4_uc003yat.1_Missense_Mutation_p.R780T|ZFHX4_uc003yau.1_Missense_Mutation_p.R780T|ZFHX4_uc003yaw.1_Missense_Mutation_p.R780T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	780	C2H2-type 4; degenerate.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---	capture		Missense_Mutation	SNP	77618662	77618662	18223	8	G	C	C	35	35	ZFHX4	C	3	3
PKHD1L1	93035	broad.mit.edu	37	8	110457075	110457075	+	Silent	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110457075A>G	uc003yne.2	+	38	5081	c.4977A>G	c.(4975-4977)CCA>CCG	p.P1659P		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1659	IPT/TIG 9.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---	capture		Silent	SNP	110457075	110457075	12397	8	A	G	G	5	5	PKHD1L1	G	4	4
FAM135B	51059	broad.mit.edu	37	8	139268978	139268978	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139268978C>G	uc003yuy.2	-	5	493	c.322G>C	c.(322-324)GAT>CAT	p.D108H	FAM135B_uc003yux.2_Missense_Mutation_p.D9H|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	108										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)												HNSCC(54;0.14)			---	---	---	---	capture		Missense_Mutation	SNP	139268978	139268978	5646	8	C	G	G	32	32	FAM135B	G	3	3
KCNV2	169522	broad.mit.edu	37	9	2729463	2729463	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2729463G>T	uc003zho.1	+	2	1588	c.1374G>T	c.(1372-1374)GTG>GTT	p.V458V		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	458	Selectivity filter (By similarity).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)														---	---	---	---	capture		Silent	SNP	2729463	2729463	8400	9	G	T	T	47	47	KCNV2	T	2	2
TLN1	7094	broad.mit.edu	37	9	35710609	35710609	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35710609G>T	uc003zxt.2	-	33	4629	c.4275C>A	c.(4273-4275)GCC>GCA	p.A1425A		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1425	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---	capture		Silent	SNP	35710609	35710609	16477	9	G	T	T	47	47	TLN1	T	2	2
TLN1	7094	broad.mit.edu	37	9	35720146	35720146	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35720146T>C	uc003zxt.2	-	13	1708	c.1354A>G	c.(1354-1356)ATC>GTC	p.I452V		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	452					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---	capture		Missense_Mutation	SNP	35720146	35720146	16477	9	T	C	C	51	51	TLN1	C	4	4
C9orf85	138241	broad.mit.edu	37	9	74526735	74526735	+	Nonsense_Mutation	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:74526735A>T	uc004ain.2	+	1	313	c.85A>T	c.(85-87)AAA>TAA	p.K29*	C9orf85_uc004aio.2_RNA|C9orf85_uc010mou.2_RNA|C9orf85_uc010mov.2_RNA|FAM108B1_uc004ail.2_5'Flank|FAM108B1_uc004aim.1_5'Flank	NM_182505	NP_872311	Q96MD7	CI085_HUMAN	hypothetical protein LOC138241	29	Lys-rich.										0																		---	---	---	---	capture		Nonsense_Mutation	SNP	74526735	74526735	2617	9	A	T	T	13	13	C9orf85	T	5	4
PRUNE2	158471	broad.mit.edu	37	9	79325136	79325136	+	Nonsense_Mutation	SNP	G	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79325136G>C	uc010mpk.2	-	8	2178	c.2054C>G	c.(2053-2055)TCA>TGA	p.S685*		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	685					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0																		---	---	---	---	capture		Nonsense_Mutation	SNP	79325136	79325136	13092	9	G	C	C	45	45	PRUNE2	C	5	3
AGTPBP1	23287	broad.mit.edu	37	9	88200380	88200380	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88200380T>A	uc011ltd.1	-	22	3196	c.3163A>T	c.(3163-3165)AGG>TGG	p.R1055W	AGTPBP1_uc004aod.3_Missense_Mutation_p.R681W|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.R1015W|AGTPBP1_uc011lte.1_Missense_Mutation_p.R1067W	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1055					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7																		---	---	---	---	capture		Missense_Mutation	SNP	88200380	88200380	403	9	T	A	A	55	55	AGTPBP1	A	4	4
C9orf79	286234	broad.mit.edu	37	9	90502753	90502753	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90502753G>T	uc004app.3	+	4	3386	c.3351G>T	c.(3349-3351)CCG>CCT	p.P1117P		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1117						integral to membrane				ovary(3)	3																		---	---	---	---	capture		Silent	SNP	90502753	90502753	2613	9	G	T	T	39	39	C9orf79	T	1	1
PHF2	5253	broad.mit.edu	37	9	96416756	96416756	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96416756G>T	uc004aub.2	+	7	998	c.851G>T	c.(850-852)TGG>TTG	p.W284L	PHF2_uc011lug.1_Missense_Mutation_p.W167L	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	284	JmjC.				liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)														---	---	---	---	capture		Missense_Mutation	SNP	96416756	96416756	12253	9	G	T	T	47	47	PHF2	T	2	2
PHF2	5253	broad.mit.edu	37	9	96437969	96437969	+	Silent	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96437969C>T	uc004aub.2	+	20	2877	c.2730C>T	c.(2728-2730)GTC>GTT	p.V910V	PHF2_uc011lug.1_Silent_p.V793V|PHF2_uc004auc.2_Silent_p.V330V	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	910					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)														---	---	---	---	capture		Silent	SNP	96437969	96437969	12253	9	C	T	T	31	31	PHF2	T	1	1
FAM22G	441457	broad.mit.edu	37	9	99700212	99700212	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:99700212C>A	uc004awq.1	+	6	2084	c.1369C>A	c.(1369-1371)CCA>ACA	p.P457T	HIATL2_uc004awr.1_Intron	NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	457										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)																---	---	---	---	capture		Missense_Mutation	SNP	99700212	99700212	5761	9	C	A	A	22	22	FAM22G	A	2	2
COL15A1	1306	broad.mit.edu	37	9	101747997	101747997	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101747997C>T	uc004azb.1	+	3	457	c.251C>T	c.(250-252)CCA>CTA	p.P84L	COL15A1_uc004aza.2_Missense_Mutation_p.P84L	NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	84	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)																---	---	---	---	capture		Missense_Mutation	SNP	101747997	101747997	3810	9	C	T	T	21	21	COL15A1	T	2	2
HSPA5	3309	broad.mit.edu	37	9	128001220	128001220	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:128001220C>A	uc004bpn.2	-	5	1252	c.996G>T	c.(994-996)ATG>ATT	p.M332I		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	332					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)										Prostate(1;0.17)			---	---	---	---	capture		Missense_Mutation	SNP	128001220	128001220	7713	9	C	A	A	21	21	HSPA5	A	2	2
OFD1	8481	broad.mit.edu	37	X	13774698	13774698	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:13774698T>A	uc004cvp.3	+	13	1582	c.1223T>A	c.(1222-1224)CTT>CAT	p.L408H	OFD1_uc004cvr.3_Translation_Start_Site|OFD1_uc011mil.1_Translation_Start_Site|OFD1_uc004cvq.3_Missense_Mutation_p.L268H|OFD1_uc010nen.2_Missense_Mutation_p.L407H|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.L367H|OFD1_uc004cvv.3_Missense_Mutation_p.L367H	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	408	Potential.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0																		---	---	---	---	capture		Missense_Mutation	SNP	13774698	13774698	11243	23	T	A	A	56	56	OFD1	A	4	4
MAP3K15	389840	broad.mit.edu	37	X	19398285	19398285	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19398285T>C	uc004czk.1	-	20	2604	c.967A>G	c.(967-969)AAG>GAG	p.K323E	MAP3K15_uc004czj.1_Missense_Mutation_p.K283E	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	848	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)																	---	---	---	---	capture		Missense_Mutation	SNP	19398285	19398285	9632	23	T	C	C	63	63	MAP3K15	C	4	4
ZNF645	158506	broad.mit.edu	37	X	22291549	22291549	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:22291549C>A	uc004dai.1	+	1	490	c.441C>A	c.(439-441)AGC>AGA	p.S147R		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	147						intracellular	zinc ion binding			lung(1)|pancreas(1)	2																		---	---	---	---	capture		Missense_Mutation	SNP	22291549	22291549	18656	23	C	A	A	27	27	ZNF645	A	1	1
DCAF8L1	139425	broad.mit.edu	37	X	27997798	27997798	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:27997798C>A	uc004dbx.1	-	1	1769	c.1654G>T	c.(1654-1656)GTG>TTG	p.V552L		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	552										ovary(3)|skin(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	27997798	27997798	4448	23	C	A	A	19	19	DCAF8L1	A	1	1
CXorf21	80231	broad.mit.edu	37	X	30577646	30577646	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30577646A>G	uc004dcg.1	-	3	1103	c.827T>C	c.(826-828)TTG>TCG	p.L276S		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	276										ovary(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	30577646	30577646	4261	23	A	G	G	5	5	CXorf21	G	4	4
RPGR	6103	broad.mit.edu	37	X	38146392	38146392	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:38146392C>G	uc004ded.1	-	15	2028	c.1860G>C	c.(1858-1860)AAG>AAC	p.K620N	RPGR_uc004deb.2_Missense_Mutation_p.K620N|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	620	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	38146392	38146392	14027	23	C	G	G	24	24	RPGR	G	3	3
EFHC2	80258	broad.mit.edu	37	X	44120491	44120491	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44120491A>G	uc004dgb.3	-	5	526	c.436T>C	c.(436-438)TTT>CTT	p.F146L		NM_025184	NP_079460	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	146	DM10 1.						calcium ion binding			breast(3)|ovary(2)|central_nervous_system(1)	6																		---	---	---	---	capture		Missense_Mutation	SNP	44120491	44120491	5135	23	A	G	G	2	2	EFHC2	G	4	4
ZNF630	57232	broad.mit.edu	37	X	47918465	47918465	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47918465C>T	uc004div.3	-	5	1618	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.E332K	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2																		---	---	---	---	capture		Missense_Mutation	SNP	47918465	47918465	18649	23	C	T	T	32	32	ZNF630	T	2	2
PAGE1	8712	broad.mit.edu	37	X	49459326	49459326	+	Nonsense_Mutation	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49459326A>T	uc004dom.2	-	2	181	c.48T>A	c.(46-48)TAT>TAA	p.Y16*		NM_003785	NP_003776	O75459	GAGB1_HUMAN	P antigen family, member 1	16					cellular defense response					skin(1)	1	Ovarian(276;0.236)																	---	---	---	---	capture		Nonsense_Mutation	SNP	49459326	49459326	11805	23	A	T	T	8	8	PAGE1	T	5	4
CLCN5	1184	broad.mit.edu	37	X	49840470	49840470	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49840470G>A	uc004dos.1	+	4	474	c.226G>A	c.(226-228)GAC>AAC	p.D76N	CLCN5_uc004dor.1_Missense_Mutation_p.D146N|CLCN5_uc004doq.1_Missense_Mutation_p.D146N|CLCN5_uc004dot.1_Missense_Mutation_p.D76N	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	76	Helical; (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)																	---	---	---	---	capture		Missense_Mutation	SNP	49840470	49840470	3602	23	G	A	A	33	33	CLCN5	A	2	2
MSN	4478	broad.mit.edu	37	X	64953069	64953069	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64953069C>A	uc004dwf.2	+	7	920	c.722C>A	c.(721-723)CCC>CAC	p.P241H		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	241	FERM.				leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10								T	ALK	ALCL								---	---	---	---	capture		Missense_Mutation	SNP	64953069	64953069	10278	23	C	A	A	22	22	MSN	A	2	2
AR	367	broad.mit.edu	37	X	66766093	66766093	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:66766093C>G	uc004dwu.1	+	1	2220	c.1105C>G	c.(1105-1107)CTG>GTG	p.L369V	AR_uc011mpd.1_Missense_Mutation_p.L369V|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.L369V	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	367	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)									Androgen_Insensitivity_Syndrome				---	---	---	---	capture		Missense_Mutation	SNP	66766093	66766093	847	23	C	G	G	20	20	AR	G	3	3
KIF4A	24137	broad.mit.edu	37	X	69615650	69615650	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69615650G>T	uc004dyg.2	+	21	2489	c.2362G>T	c.(2362-2364)GGG>TGG	p.G788W	KIF4A_uc010nkw.2_Missense_Mutation_p.G788W	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	788	Potential.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4																		---	---	---	---	capture		Missense_Mutation	SNP	69615650	69615650	8614	23	G	T	T	47	47	KIF4A	T	2	2
MED12	9968	broad.mit.edu	37	X	70347811	70347811	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70347811G>T	uc004dyy.2	+	22	3249	c.3050G>T	c.(3049-3051)TGG>TTG	p.W1017L	MED12_uc011mpq.1_Missense_Mutation_p.W1017L|MED12_uc004dyz.2_Missense_Mutation_p.W1017L|MED12_uc004dza.2_Missense_Mutation_p.W864L|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1017					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)																	---	---	---	---	capture		Missense_Mutation	SNP	70347811	70347811	9817	23	G	T	T	47	47	MED12	T	2	2
CYSLTR1	10800	broad.mit.edu	37	X	77528442	77528442	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77528442C>T	uc004edb.2	-	3	1202	c.802G>A	c.(802-804)GAT>AAT	p.D268N	CYSLTR1_uc010nma.2_Missense_Mutation_p.D268N|CYSLTR1_uc010nmb.2_Missense_Mutation_p.D268N	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	268	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)													---	---	---	---	capture		Missense_Mutation	SNP	77528442	77528442	4366	23	C	T	T	29	29	CYSLTR1	T	2	2
CYLC1	1538	broad.mit.edu	37	X	83128189	83128189	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:83128189C>A	uc004eei.1	+	4	494	c.473C>A	c.(472-474)GCA>GAA	p.A158E	CYLC1_uc004eeh.1_Missense_Mutation_p.A157E	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	158					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5																		---	---	---	---	capture		Missense_Mutation	SNP	83128189	83128189	4306	23	C	A	A	25	25	CYLC1	A	2	2
PABPC5	140886	broad.mit.edu	37	X	90691646	90691646	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:90691646C>T	uc004efg.2	+	2	1510	c.1070C>T	c.(1069-1071)GCA>GTA	p.A357V	PABPC5_uc004eff.1_Missense_Mutation_p.A193V	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	357	RRM 4.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	90691646	90691646	11783	23	C	T	T	25	25	PABPC5	T	2	2
BTK	695	broad.mit.edu	37	X	100630231	100630231	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100630231G>T	uc004ehg.2	-	2	235	c.42C>A	c.(40-42)TCC>TCA	p.S14S	BTK_uc010nnn.2_Silent_p.S14S|BTK_uc010nno.2_Silent_p.S48S|BTK_uc004ehi.2_Silent_p.S14S	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	14	PH.		S -> F (in XLA).		calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6														Agammaglobulinemia_X-linked				---	---	---	---	capture		Silent	SNP	100630231	100630231	1591	23	G	T	T	43	43	BTK	T	2	2
GPRASP1	9737	broad.mit.edu	37	X	101912635	101912635	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:101912635C>A	uc004ejj.3	+	5	4595	c.3794C>A	c.(3793-3795)ACT>AAT	p.T1265N	GPRASP1_uc004eji.3_Missense_Mutation_p.T1265N|GPRASP1_uc010nod.2_Missense_Mutation_p.T1265N	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1265	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2																		---	---	---	---	capture		Missense_Mutation	SNP	101912635	101912635	6998	23	C	A	A	20	20	GPRASP1	A	2	2
BEX4	56271	broad.mit.edu	37	X	102471237	102471237	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102471237G>T	uc004ejv.3	+	3	391	c.156G>T	c.(154-156)CGG>CGT	p.R52R	BEX4_uc004ejw.3_Silent_p.R52R	NM_001080425	NP_001073894	Q9NWD9	BEX4_HUMAN	BEX family member 4	52						cytoplasm|nucleus				skin(1)	1																		---	---	---	---	capture		Silent	SNP	102471237	102471237	1436	23	G	T	T	43	43	BEX4	T	2	2
TCEAL3	85012	broad.mit.edu	37	X	102864368	102864368	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102864368C>A	uc004ekq.2	+	3	638	c.376C>A	c.(376-378)CAG>AAG	p.Q126K	TCEAL3_uc004ekr.2_Missense_Mutation_p.Q126K	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0																		---	---	---	---	capture		Missense_Mutation	SNP	102864368	102864368	16198	23	C	A	A	29	29	TCEAL3	A	2	2
ESX1	80712	broad.mit.edu	37	X	103495396	103495396	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:103495396G>A	uc004ely.2	-	4	792	c.734C>T	c.(733-735)CCT>CTT	p.P245L		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	245	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.|1.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	103495396	103495396	5456	23	G	A	A	35	35	ESX1	A	2	2
TBC1D8B	54885	broad.mit.edu	37	X	106083927	106083927	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106083927C>A	uc004emo.2	+	10	1697	c.1532C>A	c.(1531-1533)CCT>CAT	p.P511H	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emn.2_Missense_Mutation_p.P511H	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	511	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	106083927	106083927	16152	23	C	A	A	24	24	TBC1D8B	A	2	2
TBC1D8B	54885	broad.mit.edu	37	X	106097494	106097494	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106097494C>A	uc004emo.2	+	14	2485	c.2320C>A	c.(2320-2322)CAG>AAG	p.Q774K	MORC4_uc004emp.3_Intron	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	774						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---	capture		Missense_Mutation	SNP	106097494	106097494	16152	23	C	A	A	17	17	TBC1D8B	A	2	2
AMOT	154796	broad.mit.edu	37	X	112024186	112024186	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:112024186G>T	uc004epr.2	-	9	2401	c.2401C>A	c.(2401-2403)CAC>AAC	p.H801N	AMOT_uc004eps.2_Missense_Mutation_p.H392N|AMOT_uc011mtc.1_Missense_Mutation_p.H41N|hsa-mir-4329|MI0015901_5'Flank	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	801					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1																		---	---	---	---	capture		Missense_Mutation	SNP	112024186	112024186	585	23	G	T	T	47	47	AMOT	T	2	2
SLC6A14	11254	broad.mit.edu	37	X	115577907	115577907	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:115577907G>T	uc004eqi.2	+	7	894	c.790G>T	c.(790-792)GTG>TTG	p.V264L	SLC6A14_uc011mtm.1_RNA	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	264	Helical; Name=5; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)													---	---	---	---	capture		Missense_Mutation	SNP	115577907	115577907	15174	23	G	T	T	44	44	SLC6A14	T	2	2
ZCCHC12	170261	broad.mit.edu	37	X	117959684	117959684	+	Silent	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117959684T>A	uc004equ.2	+	4	950	c.477T>A	c.(475-477)GCT>GCA	p.A159A		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1																		---	---	---	---	capture		Silent	SNP	117959684	117959684	18169	23	T	A	A	53	53	ZCCHC12	A	4	4
UPF3B	65109	broad.mit.edu	37	X	118972475	118972475	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118972475C>A	uc004erz.1	-	9	939	c.862G>T	c.(862-864)GAA>TAA	p.E288*	UPF3B_uc004esa.1_Nonsense_Mutation_p.E275*	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	288	Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3																		---	---	---	---	capture		Nonsense_Mutation	SNP	118972475	118972475	17566	23	C	A	A	32	32	UPF3B	A	5	2
UPF3B	65109	broad.mit.edu	37	X	118975200	118975200	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118975200C>T	uc004erz.1	-	7	723	c.646G>A	c.(646-648)GAA>AAA	p.E216K	UPF3B_uc004esa.1_Missense_Mutation_p.E216K	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	216	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	118975200	118975200	17566	23	C	T	T	32	32	UPF3B	T	2	2
UPF3B	65109	broad.mit.edu	37	X	118977226	118977226	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118977226C>T	uc004erz.1	-	5	585	c.508G>A	c.(508-510)GAT>AAT	p.D170N	UPF3B_uc004esa.1_Missense_Mutation_p.D170N	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	170	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3																		---	---	---	---	capture		Missense_Mutation	SNP	118977226	118977226	17566	23	C	T	T	32	32	UPF3B	T	2	2
THOC2	57187	broad.mit.edu	37	X	122801009	122801009	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:122801009C>T	uc004etu.2	-	11	1170	c.1138G>A	c.(1138-1140)GCC>ACC	p.A380T	THOC2_uc011muh.1_Missense_Mutation_p.A301T|THOC2_uc011mui.1_Missense_Mutation_p.A265T	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	380					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3																		---	---	---	---	capture		Missense_Mutation	SNP	122801009	122801009	16393	23	C	T	T	28	28	THOC2	T	2	2
CCDC160	347475	broad.mit.edu	37	X	133379769	133379769	+	Silent	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133379769A>T	uc011mvj.1	+	2	1260	c.939A>T	c.(937-939)TCA>TCT	p.S313S		NM_001101357	NP_001094827	A6NGH7	CC160_HUMAN	coiled-coil domain containing 160	313										skin(1)	1																		---	---	---	---	capture		Silent	SNP	133379769	133379769	2914	23	A	T	T	8	8	CCDC160	T	4	4
ZNF75D	7626	broad.mit.edu	37	X	134421514	134421514	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134421514T>A	uc004eyp.2	-	7	3743	c.1088A>T	c.(1087-1089)AAA>ATA	p.K363I	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Missense_Mutation_p.K142I|ZNF75D_uc004eyo.2_Missense_Mutation_p.K268I	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	363					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---	capture		Missense_Mutation	SNP	134421514	134421514	18732	23	T	A	A	64	64	ZNF75D	A	4	4
GPR112	139378	broad.mit.edu	37	X	135496475	135496475	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135496475G>T	uc004ezu.1	+	25	9485	c.9194G>T	c.(9193-9195)AGC>ATC	p.S3065I	GPR112_uc010nsb.1_Missense_Mutation_p.S2860I	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	3065	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---	capture		Missense_Mutation	SNP	135496475	135496475	6903	23	G	T	T	34	34	GPR112	T	2	2
GPR101	83550	broad.mit.edu	37	X	136112439	136112439	+	Silent	SNP	G	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:136112439G>T	uc011mwh.1	-	1	1395	c.1395C>A	c.(1393-1395)ATC>ATA	p.I465I		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	465	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---	capture		Silent	SNP	136112439	136112439	6896	23	G	T	T	41	41	GPR101	T	2	2
MCF2	4168	broad.mit.edu	37	X	138708792	138708792	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138708792T>C	uc004fau.2	-	5	856	c.562A>G	c.(562-564)ACT>GCT	p.T188A	MCF2_uc004fav.2_Missense_Mutation_p.T188A|MCF2_uc011mwl.1_Missense_Mutation_p.T149A|MCF2_uc010nsh.1_Missense_Mutation_p.T188A|MCF2_uc011mwm.1_Missense_Mutation_p.T149A|MCF2_uc011mwn.1_Missense_Mutation_p.T333A|MCF2_uc004faw.2_Missense_Mutation_p.T248A|MCF2_uc011mwo.1_Missense_Mutation_p.T248A	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	188					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---	capture		Missense_Mutation	SNP	138708792	138708792	9767	23	T	C	C	60	60	MCF2	C	4	4
CXorf66	347487	broad.mit.edu	37	X	139038261	139038261	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:139038261T>A	uc004fbb.2	-	3	902	c.880A>T	c.(880-882)ACT>TCT	p.T294S		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	294	Cytoplasmic (Potential).					integral to membrane					0																		---	---	---	---	capture		Missense_Mutation	SNP	139038261	139038261	4283	23	T	A	A	59	59	CXorf66	A	4	4
MAGEC3	139081	broad.mit.edu	37	X	140969303	140969303	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140969303G>A	uc011mwp.1	+	4	630	c.630G>A	c.(628-630)ATG>ATA	p.M210I		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	210	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---	capture		Missense_Mutation	SNP	140969303	140969303	9563	23	G	A	A	46	46	MAGEC3	A	2	2
SLITRK4	139065	broad.mit.edu	37	X	142718108	142718108	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:142718108G>A	uc004fbx.2	-	2	1193	c.817C>T	c.(817-819)CGC>TGC	p.R273C	SLITRK4_uc004fby.2_Missense_Mutation_p.R273C	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	273	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---	capture		Missense_Mutation	SNP	142718108	142718108	15243	23	G	A	A	38	38	SLITRK4	A	1	1
F8	2157	broad.mit.edu	37	X	154185349	154185349	+	Silent	SNP	A	T	T			TCGA-66-2727-01	TCGA-66-2727-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154185349A>T	uc004fmt.2	-	11	1806	c.1635T>A	c.(1633-1635)CCT>CCA	p.P545P		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	545	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)													---	---	---	---	capture		Silent	SNP	154185349	154185349	5544	23	A	T	T	11	11	F8	T	4	4
