Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
GAD2	2572	broad.mit.edu	36	10	26546821	26546821	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0151-01	TCGA-06-0151-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr10:26546821A>G	uc001isp.1	+	c.181A>G	c.(181-183)AGC>GGC	p.S61G	GAD2_uc001isq.1_Missense_Mutation_p.S61G|GAD2_uc009xkr.1_Missense_Mutation_p.S61G	NM_000818	NP_000809	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	61					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)	1					L-Glutamic Acid(DB00142)									0.4	6.478668	6.570426	4	6	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	26546821	26546821	6431	10	A	G	G	11	11	GAD2	G	4	4
KRT7	3855	broad.mit.edu	36	12	50925489	50925489	+	Silent	SNP	C	T	T			TCGA-06-0151-01	TCGA-06-0151-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:50925489C>T	uc001saa.1	+	c.1011C>T	c.(1009-1011)GCC>GCT	p.A337A	KRT7_uc009zmf.1_Intron	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	337	Rod.|Coil 2.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0														0.25	36.322532	39.504365	14	42	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(357;0.105)	Silent	SNP	50925489	50925489	8798	12	C	T	T	23	23	KRT7	T	1	1
MYO1A	4640	broad.mit.edu	36	12	55718091	55718091	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0151-01	TCGA-06-0151-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:55718091C>T	uc001smw.2	-	c.1790G>A	c.(1789-1791)CGA>CAA	p.R597Q	MYO1A_uc009zpd.1_Missense_Mutation_p.R597Q	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	597	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|urinary_tract(1)|skin(1)	4														0.321839	154.447411	159.347856	56	118	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55718091	55718091	10463	12	C	T	T	31	31	MYO1A	T	1	1
FARP1	10160	broad.mit.edu	36	13	97881500	97881500	+	Missense_Mutation	SNP	A	C	C			TCGA-06-0151-01	TCGA-06-0151-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr13:97881500A>C	uc001vnh.1	+	c.2108A>C	c.(2107-2109)CAC>CCC	p.H703P	FARP1_uc001vnj.1_Missense_Mutation_p.H703P	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	703	DH.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)													0.8	7.042718	7.428637	4	1	AA		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(86;0.233)		Missense_Mutation	SNP	97881500	97881500	5912	13	A	C	C	6	6	FARP1	C	4	4
COMMD4	54939	broad.mit.edu	36	15	73417770	73417770	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0151-01	TCGA-06-0151-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:73417770C>G	uc002azy.1	+	c.97C>G	c.(97-99)CTC>GTC	p.L33V	COMMD4_uc002azz.1_Missense_Mutation_p.L33V|COMMD4_uc002baa.1_Missense_Mutation_p.L33V	NM_017828	NP_060298	Q9H0A8	COMD4_HUMAN	COMM domain containing 4	33						cytoplasm	protein binding				0														0.428571	7.131652	7.160734	3	4	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	73417770	73417770	3856	15	C	G	G	28	28	COMMD4	G	3	3
KRT222	125113	broad.mit.edu	36	17	36066320	36066320	+	Nonsense_Mutation	SNP	G	A	A			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:36066320G>A	uc002hvc.2	-	c.748C>T	c.(748-750)CGA>TGA	p.R250*	KRT222_uc002hvb.2_Nonsense_Mutation_p.R210*	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	250						intermediate filament	structural molecule activity			central_nervous_system(1)	1														0.124031	20.507479	38.338645	16	113	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	36066320	36066320	8774	17	G	A	A	37	37	KRT222	A	5	1
CC2D1A	54862	broad.mit.edu	36	19	13885036	13885036	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0151-01	TCGA-06-0151-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:13885036C>G	uc002mxo.1	+	c.434C>G	c.(433-435)GCG>GGG	p.A145G	CC2D1A_uc002mxp.1_Missense_Mutation_p.A145G|CC2D1A_uc010dzh.1_5'UTR|CC2D1A_uc002mxn.1_Missense_Mutation_p.A44G	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	145					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0														0.259259	8.458436	10.04189	7	20	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)		Missense_Mutation	SNP	13885036	13885036	2846	19	C	G	G	27	27	CC2D1A	G	3	3
ACPT	93650	broad.mit.edu	36	19	55987211	55987211	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:55987211G>A	uc002pta.1	+	c.520G>A	c.(520-522)GAG>AAG	p.E174K		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	174	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)												0.52381	32.526628	32.537132	11	10	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)	Missense_Mutation	SNP	55987211	55987211	169	19	G	A	A	37	37	ACPT	A	1	1
ZNF470	388566	broad.mit.edu	36	19	61780849	61780849	+	Nonsense_Mutation	SNP	C	T	T			TCGA-06-0151-01	TCGA-06-0151-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:61780849C>T	uc002qnl.2	+	c.1240C>T	c.(1240-1242)CAG>TAG	p.Q414*	ZNF470_uc010etn.1_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	414	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)												0.348387	146.595151	149.743236	54	101	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(193;0.0294)	Nonsense_Mutation	SNP	61780849	61780849	18523	19	C	T	T	29	29	ZNF470	T	5	2
TNN	63923	broad.mit.edu	36	1	173364380	173364380	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:173364380G>A	uc001gkl.1	+	c.3205G>A	c.(3205-3207)GAC>AAC	p.D1069N		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N	1069	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)								470				0.305195	119.196562	124.457432	47	107	GG		KEEP	---	---	---	---	capture		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)	Missense_Mutation	SNP	173364380	173364380	16864	1	G	A	A	41	41	TNN	A	2	2
CFHR5	81494	broad.mit.edu	36	1	195231599	195231599	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0151-01	TCGA-06-0151-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:195231599C>G	uc001gts.2	+	c.737C>G	c.(736-738)CCT>CGT	p.P246R		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	246	Sushi 4.				complement activation, alternative pathway	extracellular region				breast(1)	1														0.233333	34.517263	38.424177	14	46	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	195231599	195231599	3421	1	C	G	G	24	24	CFHR5	G	3	3
DDX59	83479	broad.mit.edu	36	1	198901810	198901810	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:198901810G>A	uc009wzk.1	-	c.682C>T	c.(682-684)CCC>TCC	p.P228S	DDX59_uc001gvi.2_Missense_Mutation_p.P228S	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	228	Q motif.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4														0.312796	178.069007	184.653753	66	145	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	198901810	198901810	4547	1	G	A	A	41	41	DDX59	A	2	2
SLC35E4	339665	broad.mit.edu	36	22	29372730	29372730	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:29372730G>T	uc003ais.1	+	c.765G>T	c.(763-765)TGG>TGT	p.W255C	SLC35E4_uc003ait.2_Intron	NM_001001479	NP_001001479	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	255	Leu-rich.					integral to membrane					0														0.292683	29.481767	31.060944	12	29	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	29372730	29372730	15084	22	G	T	T	43	43	SLC35E4	T	3	3
ZRANB3	84083	broad.mit.edu	36	2	135681694	135681694	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:135681694G>T	uc002tum.1	-	c.2789C>A	c.(2788-2790)TCT>TAT	p.S930Y	ZRANB3_uc002tuk.1_Missense_Mutation_p.S473Y|ZRANB3_uc002tul.1_Missense_Mutation_p.S928Y	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	930						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding				0														0.231214	178.607804	201.523776	80	266	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(221;0.135)	Missense_Mutation	SNP	135681694	135681694	18828	2	G	T	T	33	33	ZRANB3	T	3	3
NLGN1	22871	broad.mit.edu	36	3	175481225	175481225	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:175481225G>C	uc003fio.1	+	c.1910G>C	c.(1909-1911)AGA>ACA	p.R637T	NLGN1_uc003fip.1_Missense_Mutation_p.R637T	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	654	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of excitatory postsynaptic membrane potential|regulation of N-methyl-D-aspartate selective glutamate receptor activity|regulation of synaptic transmission|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	carboxylesterase activity|cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	Ovarian(172;0.0025)													0.206522	97.078646	111.743792	38	146	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)		Missense_Mutation	SNP	175481225	175481225	10864	3	G	C	C	33	33	NLGN1	C	3	3
RAD54L2	23132	broad.mit.edu	36	3	51665094	51665094	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0151-01	TCGA-06-0151-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:51665094C>T	uc003dbi.2	+	c.2770C>T	c.(2770-2772)CCC>TCC	p.P924S	RAD54L2_uc003dbh.1_Missense_Mutation_p.P621S|RAD54L2_uc003dbj.1_Missense_Mutation_p.P358S	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	1032						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3														0.245536	131.996553	145.223039	55	169	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)	Missense_Mutation	SNP	51665094	51665094	13454	3	C	T	T	22	22	RAD54L2	T	2	2
ALB	213	broad.mit.edu	36	4	74493317	74493317	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:74493317G>A	uc003hgs.2	+	c.413G>A	c.(412-414)CGA>CAA	p.R138Q	ALB_uc003hgt.2_Missense_Mutation_p.R138Q|ALB_uc003hgu.2_Intron|ALB_uc010iii.1_Intron|ALB_uc003hgv.2_Intron|ALB_uc003hgw.2_Intron|ALB_uc010iij.1_Non-coding_Transcript|ALB_uc003hgx.2_5'Flank	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	138	Albumin 1.		R -> G (in Yanomama-2).		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)	3	Breast(15;0.00102)				Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)									0.238806	39.166101	43.340491	16	51	GG		KEEP	---	---	---	---	capture	Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Missense_Mutation	SNP	74493317	74493317	489	4	G	A	A	37	37	ALB	A	1	1
PCDHB5	26167	broad.mit.edu	36	5	140497118	140497118	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0151-01	TCGA-06-0151-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140497118G>A	uc003liq.1	+	c.1918G>A	c.(1918-1920)GTG>ATG	p.V640M		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	640	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(2)	2														0.520408	147.114422	147.149389	51	47	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)		Missense_Mutation	SNP	140497118	140497118	11965	5	G	A	A	44	44	PCDHB5	A	2	2
BRAF	673	broad.mit.edu	36	7	140099605	140099605	+	Missense_Mutation	SNP	A	T	T			TCGA-06-0151-01	TCGA-06-0151-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:140099605A>T	uc003vwc.2	-	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15573)|p.V600?(188)|p.V600K(165)|p.V600R(36)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_R603>I(2)|p.V600_W604del(1)|p.V600L(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insT(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(211)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(7681)|large_intestine(4665)|skin(3221)|NS(366)|central_nervous_system(264)|ovary(219)|lung(77)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(27)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(16)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	16798	Melanoma(164;0.00956)				Sorafenib(DB00398)	Colon(40;35 892 2973 5743 27438)	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	p.V600E(G361-Tumor)|p.V600E(HT144-Tumor)|p.V600E(MDAMB361-Tumor)|p.V600E(COLO783-Tumor)|p.V600E(COLO201-Tumor)|p.V600E(8505C-Tumor)|p.V600E(COLO205-Tumor)|p.V600E(A673-Tumor)|p.V600E(WM88-Tumor)|p.V600E(LOXIMVI-Tumor)|p.V600D(WM2664-Tumor)|p.V600K(MDST8-Tumor)|p.V600E(HT29-Tumor)|p.V600E(CL34-Tumor)|p.V600E(COLO818-Tumor)|p.V600E(COLO741-Tumor)|p.V600E(LS411N-Tumor)|p.V600E(SKMEL28-Tumor)|p.V600E(NMCG1-Tumor)|p.V600E(MELHO-Tumor)|p.V600E(WM983B-Tumor)|p.V600E(OUMS23-Tumor)|p.V600E(NCIH854-Tumor)|p.V600E(IGR39-Tumor)|p.V600E(SKHEP1-Tumor)|p.V600E(COLO679-Tumor)|p.V600E(SKMEL5-Tumor)|p.V600E(UACC257-Tumor)|p.V600E(HS695T-Tumor)|p.V600E(A375-Tumor)|p.V600E(MALME3M-Tumor)|p.V600E(AM38-Tumor)|p.V600E(SIGM5-Tumor)|p.V600E(DBTRG05MG-Tumor)|p.V600E(8305C-Tumor)|p.V600E(SKMEL24-Tumor)|p.V600E(WM793-Tumor)|p.V600E(BCPAP-Tumor)|p.V600D(WM115-Tumor)|p.V600E(SNUC5-Tumor)|p.V600E(GCT-Tumor)|p.V600E(ES2-Tumor)|p.V600E(SW1417-Tumor)|p.V600E(MDAMB435S-Tumor)|p.V600E(HS294T-Tumor)|p.V600E(DU4475-Tumor)|p.V600E(C32-Tumor)|p.V600E(A101D-Tumor)|p.V600E(COLO829-Tumor)|p.V600E(SKMEL3-Tumor)|p.V600E(SKMEL1-Tumor)|p.V600E(WM1799-Tumor)|p.V600E(RKO-Tumor)|p.V600E(IGR37-Tumor)|p.V600E(K029AX-Tumor)|p.V600E(JHOM2B-Tumor)|p.V600E(SH4-Tumor)	451				0.378378	211.129291	213.52123	70	115	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	140099605	140099605	1527	7	A	T	T	6	6	BRAF	T	4	4
PTPRN2	5799	broad.mit.edu	36	7	157652506	157652506	+	Missense_Mutation	SNP	A	C	C			TCGA-06-0151-01	TCGA-06-0151-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:157652506A>C	uc003wno.1	-	c.788T>G	c.(787-789)CTG>CGG	p.L263R	PTPRN2_uc003wnp.1_Missense_Mutation_p.L246R|PTPRN2_uc003wnq.1_Missense_Mutation_p.L263R|PTPRN2_uc003wnr.1_Missense_Mutation_p.L225R	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	263	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)	6	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)												0.461538	9.052778	9.086881	6	7	AA		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)	Missense_Mutation	SNP	157652506	157652506	13265	7	A	C	C	7	7	PTPRN2	C	4	4
NFIB	4781	broad.mit.edu	36	9	14140145	14140145	+	Missense_Mutation	SNP	T	C	C			TCGA-06-0151-01	TCGA-06-0151-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr9:14140145T>C	uc003zlf.1	-	c.805A>G	c.(805-807)AGC>GGC	p.S269G	NFIB_uc003zld.1_Missense_Mutation_p.S17G|NFIB_uc003zle.1_Missense_Mutation_p.S269G	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	269					DNA replication	nucleolus	sequence-specific DNA binding transcription factor activity				0						Esophageal Squamous(132;921 1730 14828 40753 46471)								0.579677	833.271398	835.666592	251	182	TT		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)	Missense_Mutation	SNP	14140145	14140145	10771	9	T	C	C	55	55	NFIB	C	4	4
SELPLG	6404	broad.mit.edu	36	12	107542086	107542086	+	Frame_Shift_Del	DEL	C	-	-			TCGA-06-0151-01	TCGA-06-0151-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:107542086_107542086delC	uc001tni.2	-	c.127_127delG	c.(127-129)GCCfs	p.A43fs	SELPLG_uc001tnh.1_Frame_Shift_Del_p.A43fs	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	43	Extracellular (Potential).				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0														0.31			65	143				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	107542086	107542086	14506	12	C	-	-	26	26	SELPLG	-	5	5
FOXG1	2290	broad.mit.edu	36	14	28306713	28306739	+	In_Frame_Del	DEL	GGGCGAGGGCGGCAAGGACGGGGAGGG	-	-			TCGA-06-0151-01	TCGA-06-0151-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:28306713_28306739delGGGCGAGGGCGGCAAGGACGGGGAGGG	uc001wqe.1	+	c.477_503delGGGCGAGGGCGGCAAGGACGGGGAGGG	c.(475-504)GCGGGCGAGGGCGGCAAGGACGGGGAGGGG>GCG	p.GEGGKDGEG160del		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	160_168	Gly-rich.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of neuron differentiation|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|sensory cilium assembly|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(1)	3			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)										0.62			8	5				---	---	---	---	capture_indel			In_Frame_Del	DEL	28306713	28306739	6252	14	GGGCGAGGGCGGCAAGGACGGGGAGGG	-	-	39	39	FOXG1	-	5	5
