Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
C10orf68	79741	broad.mit.edu	36	10	33040601	33040601	+	Missense_Mutation	SNP	T	C	C			TCGA-19-2619-01	TCGA-19-2619-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr10:33040601T>C	uc001iwm.1	+	c.355T>C	c.(355-357)TCA>CCA	p.S119P	C10orf68_uc001iwl.1_Missense_Mutation_p.S151P|C10orf68_uc001iwn.2_Missense_Mutation_p.S143P	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	143										ovary(1)	1														0.755556	129.674783	132.354367	34	11	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	33040601	33040601	1650	10	T	C	C	62	62	C10orf68	C	4	4
AKR1E2	83592	broad.mit.edu	36	10	4863008	4863008	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:4863008C>T	uc001ihi.1	+	c.181C>T	c.(181-183)CGG>TGG	p.R61W	AKR1E2_uc001ihl.1_Non-coding_Transcript|AKR1E2_uc001ihh.1_Missense_Mutation_p.R61W|AKR1E2_uc009xhw.1_Missense_Mutation_p.R61W|AKR1E2_uc001ihj.1_Non-coding_Transcript|AKR1E2_uc001ihk.1_Missense_Mutation_p.R61W	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member C-like 2	61					oxidation-reduction process	cytoplasm	1,5-anhydro-D-fructose reductase activity				0						NSCLC(43;343 1097 20371 28813 45509)								0.361702	92.406232	93.995354	34	60	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	4863008	4863008	477	10	C	T	T	19	19	AKR1E2	T	1	1
ITIH2	3698	broad.mit.edu	36	10	7802875	7802875	+	Silent	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:7802875C>T	uc001ijs.1	+	c.681C>T	c.(679-681)CCC>CCT	p.P227P		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	227					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)	2														0.293706	120.700917	126.143342	42	101	CC		KEEP	---	---	---	---	capture			Silent	SNP	7802875	7802875	8208	10	C	T	T	23	23	ITIH2	T	1	1
OR8H2	390151	broad.mit.edu	36	11	55629378	55629378	+	Missense_Mutation	SNP	C	T	T	rs61750935	unknown	TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:55629378C>T	uc001nih.1	+	c.284C>T	c.(283-285)ACG>ATG	p.T95M		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Esophageal squamous(21;0.00693)													0.135443	159.482076	261.224577	107	683	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55629378	55629378	11649	11	C	T	T	19	19	OR8H2	T	1	1
PLCB3	5331	broad.mit.edu	36	11	63782996	63782996	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:63782996C>G	uc001nzb.2	+	c.1317C>G	c.(1315-1317)ATC>ATG	p.I439M	PLCB3_uc009ypg.1_Missense_Mutation_p.I439M|PLCB3_uc009yph.1_Missense_Mutation_p.I372M|PLCB3_uc009ypi.1_Missense_Mutation_p.I439M	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C, beta 3	439	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2														0.2	7.592213	9.264182	4	16	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	63782996	63782996	12455	11	C	G	G	31	31	PLCB3	G	3	3
OGFOD2	79676	broad.mit.edu	36	12	122029279	122029279	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:122029279C>G	uc001uea.1	+	c.558C>G	c.(556-558)GAC>GAG	p.D186E	OGFOD2_uc001uds.1_Missense_Mutation_p.D22E|OGFOD2_uc001udt.1_Missense_Mutation_p.D22E|OGFOD2_uc001udu.1_Missense_Mutation_p.D22E|OGFOD2_uc001udv.1_Missense_Mutation_p.D22E|OGFOD2_uc009zxs.1_Missense_Mutation_p.D22E|OGFOD2_uc001udw.1_Missense_Mutation_p.D22E|OGFOD2_uc001udx.1_Missense_Mutation_p.D22E|OGFOD2_uc001udy.1_Missense_Mutation_p.D22E|OGFOD2_uc001udz.1_Missense_Mutation_p.D126E|OGFOD2_uc001ueb.1_Missense_Mutation_p.D22E|ARL6IP4_uc001ued.1_5'Flank|ARL6IP4_uc001uec.1_5'Flank|ARL6IP4_uc001uee.1_5'Flank|ARL6IP4_uc001uef.1_5'Flank|ARL6IP4_uc001ueg.1_5'Flank|ARL6IP4_uc009zxt.1_5'Flank|ARL6IP4_uc001ueh.1_5'Flank|ARL6IP4_uc001uei.1_5'Flank	NM_024623	NP_078899	Q6N063	OGFD2_HUMAN	2-oxoglutarate and iron-dependent oxygenase	186					oxidation-reduction process		iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			pancreas(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)				Vitamin C(DB00126)									0.166667	6.485984	9.014535	4	20	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(86;6.11e-05)|Epithelial(86;0.000127)|BRCA - Breast invasive adenocarcinoma(302;0.107)	Missense_Mutation	SNP	122029279	122029279	11247	12	C	G	G	19	19	OGFOD2	G	3	3
NAV3	89795	broad.mit.edu	36	12	77115264	77115264	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:77115264C>G	uc001syp.1	+	c.6398C>G	c.(6397-6399)TCT>TGT	p.S2133C	NAV3_uc001syo.1_Missense_Mutation_p.S2111C|NAV3_uc009zsf.1_Missense_Mutation_p.S942C	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2133						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|kidney(1)|pancreas(1)	16										1091				0.340426	52.085776	53.143584	16	31	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	77115264	77115264	10581	12	C	G	G	32	32	NAV3	G	3	3
PAWR	5074	broad.mit.edu	36	12	78539085	78539085	+	Nonsense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:78539085G>A	uc001syx.1	-	c.550C>T	c.(550-552)CAG>TAG	p.Q184*		NM_002583	NP_002574	Q96IZ0	PAWR_HUMAN	PRKC, apoptosis, WT1, regulator	184	Selective for apoptosis induction in cancer cells (SAC).				actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0										121				0.371324	273.404072	277.397684	101	171	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	78539085	78539085	11897	12	G	A	A	46	46	PAWR	A	5	2
FRY	10129	broad.mit.edu	36	13	31633289	31633289	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr13:31633289G>A	uc001utx.1	+	c.1793G>A	c.(1792-1794)AGA>AAA	p.R598K	FRY_uc010abb.1_5'UTR	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)	6		Lung SC(185;0.0271)												0.468966	220.889505	221.011086	68	77	GG		KEEP	---	---	---	---	capture		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)	Missense_Mutation	SNP	31633289	31633289	6313	13	G	A	A	33	33	FRY	A	2	2
FARP1	10160	broad.mit.edu	36	13	97840247	97840247	+	Silent	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr13:97840247C>T	uc001vnh.1	+	c.891C>T	c.(889-891)GCC>GCT	p.A297A	FARP1_uc001vnj.1_Silent_p.A297A	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	297	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)													0.457265	330.357488	330.733933	107	127	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(86;0.233)		Silent	SNP	97840247	97840247	5912	13	C	T	T	21	21	FARP1	T	2	2
KIAA1409	57578	broad.mit.edu	36	14	93111286	93111286	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:93111286G>C	uc001ybv.1	+	c.1669G>C	c.(1669-1671)GCA>CCA	p.A557P	KIAA1409_uc001ybs.1_Missense_Mutation_p.A557P	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	734						integral to membrane				ovary(10)|large_intestine(3)	13		all_cancers(154;0.0354)|all_epithelial(191;0.216)								1186				0.324324	72.473795	74.501036	24	50	GG		KEEP	---	---	---	---	capture		Epithelial(152;0.188)	Missense_Mutation	SNP	93111286	93111286	8539	14	G	C	C	46	46	KIAA1409	C	3	3
UBFD1	56061	broad.mit.edu	36	16	23478384	23478384	+	Silent	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:23478384C>T	uc002dlv.1	+	c.450C>T	c.(448-450)ATC>ATT	p.I150I	EARS2_uc002dls.2_5'Flank|EARS2_uc002dlt.2_5'Flank|EARS2_uc002dlu.2_5'Flank	NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	150	Ubiquitin-like.										0						Melanoma(22;290 1069 22358 48158)								0.364865	77.804675	78.993469	27	47	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(48;0.0331)	Silent	SNP	23478384	23478384	17442	16	C	T	T	29	29	UBFD1	T	2	2
ALDH3A1	218	broad.mit.edu	36	17	19582317	19582317	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:19582317C>T	uc010cqu.1	-	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	ALDH3A1_uc002gwj.1_Missense_Mutation_p.E420K|ALDH3A1_uc010cqv.1_Missense_Mutation_p.E419K|ALDH3A1_uc002gwk.1_Missense_Mutation_p.E537K|ALDH3A1_uc002gwl.1_Missense_Mutation_p.E347K	NM_000691	NP_000682	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	420					cellular aldehyde metabolic process|oxidation-reduction process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)				NADH(DB00157)									0.375	113.903915	115.328661	39	65	CC		KEEP	---	---	---	---	capture		Colorectal(15;0.0829)	Missense_Mutation	SNP	19582317	19582317	500	17	C	T	T	31	31	ALDH3A1	T	1	1
GAS2L2	246176	broad.mit.edu	36	17	31096282	31096282	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:31096282G>A	uc002hjv.1	-	c.2347C>T	c.(2347-2349)CGG>TGG	p.R783W		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	783					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)												0.393574	297.292649	299.728563	98	151	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Missense_Mutation	SNP	31096282	31096282	6511	17	G	A	A	39	39	GAS2L2	A	1	1
GAS2L2	246176	broad.mit.edu	36	17	31101239	31101239	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:31101239C>G	uc002hjv.1	-	c.597G>C	c.(595-597)CAG>CAC	p.Q199H		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	199					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)												0.388889	14.585013	14.790201	7	11	CC		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Missense_Mutation	SNP	31101239	31101239	6511	17	C	G	G	28	28	GAS2L2	G	3	3
USH1G	124590	broad.mit.edu	36	17	70427215	70427215	+	Silent	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:70427215C>T	uc002jme.1	-	c.1311G>A	c.(1309-1311)AAG>AAA	p.K437K		NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	437	SAM.				equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	actin cytoskeleton				skin(1)	1	all_lung(278;0.172)|Lung NSC(278;0.207)													0.266667	51.064768	54.754728	20	55	CC		KEEP	---	---	---	---	capture			Silent	SNP	70427215	70427215	17597	17	C	T	T	32	32	USH1G	T	2	2
INO80C	125476	broad.mit.edu	36	18	31314421	31314421	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr18:31314421G>A	uc010dmt.1	-	c.369C>T	c.(367-369)AAC>AAT	p.N123N	INO80C_uc002kyw.1_Silent_p.N87N|INO80C_uc002kyx.2_Silent_p.N32N|INO80C_uc002kyy.2_Silent_p.N87N	NM_001098817	NP_001092287	Q6PI98	IN80C_HUMAN	Ies6-similar protein isoform 1	87						MLL1 complex					0														0.192982	51.400071	61.418574	22	92	GG		KEEP	---	---	---	---	capture			Silent	SNP	31314421	31314421	8049	18	G	A	A	36	36	INO80C	A	2	2
SERPINB4	6318	broad.mit.edu	36	18	59461387	59461387	+	Silent	SNP	A	T	T			TCGA-19-2619-01	TCGA-19-2619-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr18:59461387A>T	uc002ljf.1	-	c.210T>A	c.(208-210)GCT>GCA	p.A70A	SERPINB4_uc002lje.1_Silent_p.A70A|SERPINB4_uc002ljg.1_Intron|SERPINB4_uc002ljh.1_Silent_p.A70A	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	70					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2										163				0.242857	46.040635	50.259647	17	53	AA		KEEP	---	---	---	---	capture			Silent	SNP	59461387	59461387	14591	18	A	T	T	7	7	SERPINB4	T	4	4
CNDP1	84735	broad.mit.edu	36	18	70374617	70374617	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr18:70374617C>T	uc002llq.1	+	c.89C>T	c.(88-90)CCG>CTG	p.P30L		NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1	30					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)				Melanoma(32;1029 1042 25286 38395 44237)								0.671233	158.293834	160.191533	49	24	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(31;0.109)	Missense_Mutation	SNP	70374617	70374617	3731	18	C	T	T	23	23	CNDP1	T	1	1
SAFB2	9667	broad.mit.edu	36	19	5538916	5538916	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:5538916G>A	uc002mcd.1	-	c.2601C>T	c.(2599-2601)GAC>GAT	p.D867D		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	867	Interacts with SAFB1.|Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0						Ovarian(127;888 1728 23957 44128 52668)								0.518519	40.455122	40.463632	14	13	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)	Silent	SNP	5538916	5538916	14287	19	G	A	A	40	40	SAFB2	A	1	1
MYH14	79784	broad.mit.edu	36	19	55484697	55484697	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:55484697C>T	uc010enu.1	+	c.4945C>T	c.(4945-4947)CGG>TGG	p.R1649W	MYH14_uc002prq.1_Missense_Mutation_p.R1616W|MYH14_uc002prr.1_Missense_Mutation_p.R1608W|MYH14_uc010env.1_5'UTR|MYH14_uc002prs.1_5'UTR	NM_001077186	NP_001070654	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 1	1608	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)												0.5	15.537883	15.537883	6	6	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)	Missense_Mutation	SNP	55484697	55484697	10428	19	C	T	T	27	27	MYH14	T	1	1
FBN3	84467	broad.mit.edu	36	19	8096851	8096851	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:8096851C>T	uc002mjf.1	-	c.2656G>A	c.(2656-2658)GTC>ATC	p.V886I		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	886	EGF-like 11; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|central_nervous_system(1)|pancreas(1)	8														0.402985	79.212885	79.763755	27	40	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	8096851	8096851	5940	19	C	T	T	19	19	FBN3	T	1	1
LINGO4	339398	broad.mit.edu	36	1	150041135	150041135	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150041135G>A	uc001ezf.1	-	c.670C>T	c.(670-672)CTG>TTG	p.L224L	LINGO4_uc009wnc.1_Silent_p.L224L	NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	224	Extracellular (Potential).|LRR 7.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)													0.577778	424.462341	425.646268	130	95	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.181)		Silent	SNP	150041135	150041135	9144	1	G	A	A	35	35	LINGO4	A	2	2
UBQLN4	56893	broad.mit.edu	36	1	154278586	154278586	+	Silent	SNP	G	C	C			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:154278586G>C	uc001fna.1	-	c.1332C>G	c.(1330-1332)CTC>CTG	p.L444L		NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	444						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)	1	Hepatocellular(266;0.133)|all_neural(408;0.195)													0.147482	86.192061	119.364363	41	237	GG		KEEP	---	---	---	---	capture			Silent	SNP	154278586	154278586	17457	1	G	C	C	41	41	UBQLN4	C	3	3
UBQLN4	56893	broad.mit.edu	36	1	154288169	154288169	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:154288169C>G	uc001fna.1	-	c.212G>C	c.(211-213)GGA>GCA	p.G71A		NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	71	Ubiquitin-like.					cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)	1	Hepatocellular(266;0.133)|all_neural(408;0.195)													0.456522	364.854072	365.232555	105	125	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	154288169	154288169	17457	1	C	G	G	30	30	UBQLN4	G	3	3
IQGAP3	128239	broad.mit.edu	36	1	154767639	154767639	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:154767639G>C	uc001fpf.1	-	c.4128C>G	c.(4126-4128)ATC>ATG	p.I1376M		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1376					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)	5	all_hematologic(923;0.088)|Hepatocellular(266;0.158)													0.105051	65.726073	142.48729	52	443	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	154767639	154767639	8119	1	G	C	C	45	45	IQGAP3	C	3	3
NTRK1	4914	broad.mit.edu	36	1	155100785	155100785	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:155100785G>A	uc001fqh.1	+	c.228G>A	c.(226-228)CAG>CAA	p.Q76Q	NTRK1_uc001fqf.1_Silent_p.Q46Q|NTRK1_uc009wsi.1_5'UTR|NTRK1_uc001fqi.1_Silent_p.Q76Q|NTRK1_uc009wsk.1_Silent_p.Q76Q	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	76	Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|stomach(1)|central_nervous_system(1)	16	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)					290	TSP Lung(10;0.080)			0.730337	426.011349	434.528503	130	48	GG		KEEP	---	---	---	---	capture			Silent	SNP	155100785	155100785	11111	1	G	A	A	34	34	NTRK1	A	2	2
F5	2153	broad.mit.edu	36	1	167756412	167756412	+	Nonsense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:167756412G>A	uc001ggg.1	-	c.6163C>T	c.(6163-6165)CGA>TGA	p.R2055*		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2055	F5/8 type C 1.				cell adhesion|oxidation-reduction process|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)	5	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)									0.455285	172.291202	172.504635	56	67	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	167756412	167756412	5542	1	G	A	A	37	37	F5	A	5	1
LGR6	59352	broad.mit.edu	36	1	200554382	200554382	+	Silent	SNP	C	A	A			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:200554382C>A	uc001gxu.1	+	c.2328C>A	c.(2326-2328)GCC>GCA	p.A776A	LGR6_uc001gxv.1_Silent_p.A724A|LGR6_uc009xab.1_Non-coding_Transcript|LGR6_uc001gxw.1_Silent_p.A637A	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	776	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|pancreas(1)	8														0.803279	156.828115	162.140878	49	12	CC		KEEP	---	---	---	---	capture			Silent	SNP	200554382	200554382	9084	1	C	A	A	24	24	LGR6	A	3	3
RASSF5	83593	broad.mit.edu	36	1	204778153	204778153	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:204778153C>T	uc001hed.1	+	c.487C>T	c.(487-489)CGC>TGC	p.R163C	RASSF5_uc001hec.1_Missense_Mutation_p.R163C|RASSF5_uc001hee.1_Missense_Mutation_p.R163C	NM_182663	NP_872604	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family 5	163	Phorbol-ester/DAG-type.				apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			ovary(1)	1	Breast(84;0.183)					GBM(162;656 1984 11916 22872 31529)								0.202597	182.866786	214.468313	78	307	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(75;0.166)		Missense_Mutation	SNP	204778153	204778153	13550	1	C	T	T	23	23	RASSF5	T	1	1
MAPKAPK2	9261	broad.mit.edu	36	1	204968703	204968703	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:204968703G>A	uc001hem.1	+	c.305G>A	c.(304-306)CGC>CAC	p.R102H	MAPKAPK2_uc001hel.1_Missense_Mutation_p.R102H	NM_032960	NP_116584	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated	102	Protein kinase.				activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity				0	Breast(84;0.183)									114				0.17757	38.269907	48.738684	19	88	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(75;0.211)		Missense_Mutation	SNP	204968703	204968703	9672	1	G	A	A	38	38	MAPKAPK2	A	1	1
CR1L	1379	broad.mit.edu	36	1	205918178	205918178	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:205918178G>A	uc001hga.2	+	c.290G>A	c.(289-291)CGT>CAT	p.R97H	CR1L_uc001hfz.2_Non-coding_Transcript|CR1L_uc001hgb.1_Non-coding_Transcript	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	97	Sushi 2.					cytoplasm|extracellular region|membrane					0														0.626168	439.7023	442.695896	134	80	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	205918178	205918178	3980	1	G	A	A	40	40	CR1L	A	1	1
ESRRG	2104	broad.mit.edu	36	1	214804346	214804346	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:214804346C>G	uc001hkx.1	-	c.736G>C	c.(736-738)GAT>CAT	p.D246H	ESRRG_uc001hkw.1_Splice_Site_SNP_p.Y234_splice|ESRRG_uc009xdo.1_Splice_Site_SNP_p.Y211_splice|ESRRG_uc009xdp.1_Splice_Site_SNP_p.Y211_splice|ESRRG_uc001hky.1_Splice_Site_SNP_p.Y211_splice|ESRRG_uc001hkz.1_Splice_Site_SNP_p.Y172_splice|ESRRG_uc001hla.1_Splice_Site_SNP_p.Y211_splice|ESRRG_uc001hlb.1_Splice_Site_SNP_p.Y211_splice|ESRRG_uc001hlc.1_Splice_Site_SNP_p.Y211_splice|ESRRG_uc001hld.1_Splice_Site_SNP_p.Y211_splice|ESRRG_uc001hle.1_Splice_Site_SNP_p.Y211_splice	NM_206595	NP_996318	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 2	234					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription activator activity|zinc ion binding			ovary(1)|kidney(1)	2					Diethylstilbestrol(DB00255)									0.330357	117.837831	120.694	37	75	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Missense_Mutation	SNP	214804346	214804346	5455	1	C	G	G	32	32	ESRRG	G	3	3
TGM2	7052	broad.mit.edu	36	20	36209824	36209824	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2619-01	TCGA-19-2619-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr20:36209824A>G	uc002xhr.1	-	c.634T>C	c.(634-636)TCC>CCC	p.S212P	TGM2_uc002xhs.1_Missense_Mutation_p.S188P|TGM2_uc002xht.1_Missense_Mutation_p.S212P|TGM2_uc002xhu.2_Missense_Mutation_p.S212P	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	212					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)									0.318182	9.676258	10.347425	7	15	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	36209824	36209824	16358	20	A	G	G	11	11	TGM2	G	4	4
RASSF2	9770	broad.mit.edu	36	20	4724462	4724462	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:4724462C>T	uc002wld.1	-	c.286G>A	c.(286-288)GGA>AGA	p.G96R	RASSF2_uc002wlc.1_5'Flank|RASSF2_uc002wle.1_Non-coding_Transcript|RASSF2_uc002wlf.1_Missense_Mutation_p.G96R	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	96					cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						Melanoma(158;1891 3343 50738)								0.43871	213.481313	213.988215	68	87	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	4724462	4724462	13547	20	C	T	T	22	22	RASSF2	T	2	2
TXNRD2	10587	broad.mit.edu	36	22	18245620	18245620	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:18245620C>T	uc002zqk.1	-	c.1438G>A	c.(1438-1440)GGG>AGG	p.G480R	TXNRD2_uc002zqj.1_Non-coding_Transcript|TXNRD2_uc002zqm.1_Non-coding_Transcript|TXNRD2_uc002zqn.1_Non-coding_Transcript|TXNRD2_uc002zqo.1_Non-coding_Transcript|TXNRD2_uc002zql.1_Missense_Mutation_p.G234R|TXNRD2_uc002zqp.1_Non-coding_Transcript|TXNRD2_uc002zqq.1_Missense_Mutation_p.G130R|TXNRD2_uc002zqr.1_Missense_Mutation_p.G479R	NM_006440		Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	480					cell redox homeostasis|oxidation-reduction process|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)													0.454545	48.522669	48.581846	15	18	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	18245620	18245620	17364	22	C	T	T	22	22	TXNRD2	T	2	2
CABIN1	23523	broad.mit.edu	36	22	22902208	22902208	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:22902208C>G	uc002zzi.1	+	c.6170C>G	c.(6169-6171)GCC>GGC	p.A2057G	CABIN1_uc002zzj.1_Missense_Mutation_p.A1978G|CABIN1_uc002zzl.1_Missense_Mutation_p.A2057G|CABIN1_uc010gul.1_Intron	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	2057					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4														0.307692	6.313177	6.794637	4	9	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	22902208	22902208	2644	22	C	G	G	26	26	CABIN1	G	3	3
SMTN	6525	broad.mit.edu	36	22	29822853	29822853	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:29822853G>A	uc003ajm.1	+	c.1996G>A	c.(1996-1998)GTT>ATT	p.V666I	SMTN_uc003ajk.1_Missense_Mutation_p.V666I|SMTN_uc003ajl.1_Missense_Mutation_p.V666I|SMTN_uc003ajn.1_Missense_Mutation_p.V689I|SMTN_uc003ajo.1_Intron|SMTN_uc010gwe.1_Intron	NM_134270	NP_599032	P53814	SMTN_HUMAN	smoothelin isoform a	666					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3														0.267327	64.777997	69.71755	27	74	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	29822853	29822853	15314	22	G	A	A	48	48	SMTN	A	2	2
C22orf32	91689	broad.mit.edu	36	22	40805738	40805738	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:40805738G>C	uc003bca.1	+	c.20G>C	c.(19-21)CGC>CCC	p.R7P		NM_033318	NP_201575	Q9H4I9	CV032_HUMAN	hypothetical protein LOC91689	7						integral to membrane|mitochondrion				ovary(1)	1														0.291667	7.159291	8.155386	7	17	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	40805738	40805738	2225	22	G	C	C	38	38	C22orf32	C	3	3
MAP4K4	9448	broad.mit.edu	36	2	101852650	101852650	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:101852650G>A	uc002tbc.1	+	c.2598G>A	c.(2596-2598)GGG>GGA	p.G866G	MAP4K4_uc002tbd.1_Silent_p.G758G|MAP4K4_uc002tbe.1_Silent_p.G704G|MAP4K4_uc002tbf.1_Silent_p.G755G|MAP4K4_uc002tbg.1_Silent_p.G785G|MAP4K4_uc002tbh.1_Silent_p.G703G|MAP4K4_uc002tbi.1_Silent_p.G588G|MAP4K4_uc002tbk.1_Silent_p.G240G|MAP4K4_uc002tbl.1_5'UTR	NM_145686	NP_663719	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	785					intracellular protein kinase cascade|protein phosphorylation|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4										483				0.666667	20.355733	20.579929	6	3	GG		KEEP	---	---	---	---	capture			Silent	SNP	101852650	101852650	9645	2	G	A	A	43	43	MAP4K4	A	2	2
ALS2CR8	79800	broad.mit.edu	36	2	203514923	203514923	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:203514923C>T	uc002uzo.2	+	c.53C>T	c.(52-54)TCA>TTA	p.S18L	ALS2CR8_uc002uzp.2_Missense_Mutation_p.S18L|ALS2CR8_uc002uzm.2_Missense_Mutation_p.S18L|ALS2CR8_uc002uzn.2_Intron|ALS2CR8_uc010ftu.1_Intron	NM_001104586	NP_079020	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	18										large_intestine(1)|ovary(1)	2														0.402062	110.592746	111.409687	39	58	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	203514923	203514923	558	2	C	T	T	29	29	ALS2CR8	T	2	2
ALK	238	broad.mit.edu	36	2	29327626	29327626	+	Missense_Mutation	SNP	A	C	C			TCGA-19-2619-01	TCGA-19-2619-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr2:29327626A>C	uc002rmy.1	-	c.2053T>G	c.(2053-2055)TTC>GTC	p.F685V		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase	685	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(191)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(14)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(200)|autonomic_ganglia(95)|soft_tissue(59)|kidney(4)|large_intestine(3)|ovary(3)|central_nervous_system(1)|breast(1)|pancreas(1)	1093	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)					777				0.318182	6.471927	7.263872	7	15	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	29327626	29327626	528	2	A	C	C	2	2	ALK	C	4	4
TSSC1	7260	broad.mit.edu	36	2	3172256	3172256	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:3172256G>A	uc002qxj.1	-	c.1020C>T	c.(1018-1020)ATC>ATT	p.I340I	TSSC1_uc002qxi.1_Non-coding_Transcript	NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	340							protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)				Colon(140;1261 1762 4183 34270 49743)								0.4	11.998194	12.085586	4	6	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)	Silent	SNP	3172256	3172256	17219	2	G	A	A	37	37	TSSC1	A	1	1
ABI3BP	25890	broad.mit.edu	36	3	102051587	102051587	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:102051587G>A	uc003dun.1	-	c.1367C>T	c.(1366-1368)ACG>ATG	p.T456M	ABI3BP_uc003duo.1_Missense_Mutation_p.T498M	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding	456	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)	3														0.347826	22.996643	23.465076	8	15	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	102051587	102051587	92	3	G	A	A	40	40	ABI3BP	A	1	1
ZIC1	7545	broad.mit.edu	36	3	148611115	148611115	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:148611115G>A	uc003ewe.1	+	c.526G>A	c.(526-528)GAG>AAG	p.E176K		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	176					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|regulation of smoothened signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription activator activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2														0.393939	36.767011	37.092164	13	20	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	148611115	148611115	18269	3	G	A	A	41	41	ZIC1	A	2	2
POU4F2	5458	broad.mit.edu	36	4	147781220	147781220	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:147781220G>A	uc003ikv.1	+	c.1040G>A	c.(1039-1041)CGC>CAC	p.R347H		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	347	Homeobox.				negative regulation of transcription from RNA polymerase II promoter	nuclear speck	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulator activity			breast(1)	1	all_hematologic(180;0.151)													0.407035	237.20959	238.69035	81	118	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	147781220	147781220	12709	4	G	A	A	38	38	POU4F2	A	1	1
PCDHA5	56143	broad.mit.edu	36	5	140183325	140183325	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140183325G>A	uc003lhl.1	+	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	PCDHA1_uc003lha.1_Intron|PCDHA1_uc003lhb.1_Intron|PCDHA2_uc003lhd.1_Intron|PCDHA3_uc003lhf.1_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA4_uc003lhi.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R594H|PCDHA5_uc003lhj.1_Missense_Mutation_p.R594H	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	594	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)	2														0.464912	152.164146	152.285973	53	61	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Missense_Mutation	SNP	140183325	140183325	11947	5	G	A	A	38	38	PCDHA5	A	1	1
RGS14	10636	broad.mit.edu	36	5	176726624	176726624	+	Silent	SNP	C	A	A			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:176726624C>A	uc003mgf.1	+	c.466C>A	c.(466-468)CGG>AGG	p.R156R	RGS14_uc003mgg.1_Silent_p.R3R|RGS14_uc003mgh.1_Silent_p.R3R|RGS14_uc003mgi.1_5'Flank	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	156	RGS.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of G-protein coupled receptor protein signaling pathway|regulation of transcription in response to stress|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	centrosome|dendritic spine|nuclear body|plasma membrane|postsynaptic density|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)				NSCLC(47;353 1896 28036)								0.490196	74.868868	74.873203	25	26	CC		KEEP	---	---	---	---	capture	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Silent	SNP	176726624	176726624	13771	5	C	A	A	31	31	RGS14	A	3	3
HTR1A	3350	broad.mit.edu	36	5	63292961	63292961	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:63292961G>A	uc003jtg.1	-	c.342C>T	c.(340-342)GCC>GCT	p.A114A		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	114	Helical; Name=3; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)			Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)									0.377778	48.454782	49.047696	17	28	GG		KEEP	---	---	---	---	capture		Lung(70;0.105)	Silent	SNP	63292961	63292961	7736	5	G	A	A	43	43	HTR1A	A	2	2
PLG	5340	broad.mit.edu	36	6	161047547	161047547	+	Silent	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:161047547C>T	uc003qtm.2	+	c.168C>T	c.(166-168)GAC>GAT	p.D56D		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	56	PAN.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			ovary(1)	1					Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)									0.724138	192.922637	196.846254	63	24	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Silent	SNP	161047547	161047547	12512	6	C	T	T	19	19	PLG	T	1	1
HLA-B	3106	broad.mit.edu	36	6	31431962	31431962	+	Missense_Mutation	SNP	T	C	C			TCGA-19-2619-01	TCGA-19-2619-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr6:31431962T>C	uc003nth.2	-	c.580A>G	c.(580-582)AGA>GGA	p.R194G	HLA-C_uc003ntb.1_5'Flank|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_5'Flank|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Missense_Mutation_p.R73G|HLA-B_uc003nti.1_5'Flank|HLA-B_uc010jsn.1_Non-coding_Transcript|HLA-B_uc010jso.1_Missense_Mutation_p.R166G	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	194	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0														0.375	9.222954	9.332718	3	5	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	31431962	31431962	7487	6	T	C	C	55	55	HLA-B	C	4	4
SRF	6722	broad.mit.edu	36	6	43249699	43249699	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:43249699C>T	uc003oui.1	+	c.650C>T	c.(649-651)ACC>ATC	p.T217I		NM_003131	NP_003122	P11831	SRF_HUMAN	serum response factor (c-fos serum response	217	|Involved in dimerization.				angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|serum response element binding|specific RNA polymerase II transcription factor activity|transcription factor binding			ovary(1)|central_nervous_system(1)	2										101				0.469697	86.764877	86.821341	31	35	CC		KEEP	---	---	---	---	capture	Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)		Missense_Mutation	SNP	43249699	43249699	15657	6	C	T	T	18	18	SRF	T	2	2
DST	667	broad.mit.edu	36	6	56674650	56674650	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:56674650G>A	uc003pcz.2	-	c.316C>T	c.(316-318)CGC>TGC	p.R106C		NM_183380	NP_899236	Q03001	DYST_HUMAN	dystonin isoform 1	106	CH 1.|Actin-binding.				cell adhesion|cell cycle arrest|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasmic membrane-bounded vesicle|hemidesmosome|microtubule plus end|nucleus	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein C-terminus binding			ovary(7)|central_nervous_system(6)	13	Lung NSC(77;0.103)									2498				0.295455	35.658992	37.305111	13	31	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)		Missense_Mutation	SNP	56674650	56674650	4967	6	G	A	A	40	40	DST	A	1	1
ZNF107	51427	broad.mit.edu	36	7	63805806	63805806	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:63805806G>A	uc003ttd.1	+	c.1689G>A	c.(1687-1689)CAG>CAA	p.Q563Q	ZNF107_uc003tte.1_Silent_p.Q563Q	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	563	C2H2-type 18; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)												0.225	66.758402	75.098461	27	93	GG		KEEP	---	---	---	---	capture			Silent	SNP	63805806	63805806	18306	7	G	A	A	36	36	ZNF107	A	2	2
PCLO	27445	broad.mit.edu	36	7	82419543	82419543	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:82419543C>T	uc003uhx.2	-	c.8662G>A	c.(8662-8664)GTA>ATA	p.V2888I	PCLO_uc003uhv.2_Missense_Mutation_p.V2888I|PCLO_uc010lec.1_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2819					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity|zinc ion binding			ovary(7)	7														0.274566	246.00098	261.829588	95	251	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	82419543	82419543	12003	7	C	T	T	19	19	PCLO	T	1	1
COL1A2	1278	broad.mit.edu	36	7	93880948	93880948	+	Missense_Mutation	SNP	G	T	T			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:93880948G>T	uc003ung.1	+	c.1568G>T	c.(1567-1569)GGT>GTT	p.G523V		NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen	523					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging			central_nervous_system(3)|ovary(2)	5	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)				Collagenase(DB00048)									0.3125	178.092796	184.606193	65	143	GG		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.0031)		Missense_Mutation	SNP	93880948	93880948	3816	7	G	T	T	44	44	COL1A2	T	3	3
ENPP2	5168	broad.mit.edu	36	8	120667626	120667626	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:120667626G>A	uc003yos.1	-	c.1504C>T	c.(1504-1506)CGC>TGC	p.R502C	ENPP2_uc003yot.1_Missense_Mutation_p.R450C|ENPP2_uc010mdd.1_Missense_Mutation_p.R450C|ENPP2_uc003yor.1_Missense_Mutation_p.R89C	NM_006209	NP_006200	Q13822	ENPP2_HUMAN	autotaxin isoform 1 preproprotein	450					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|kidney(1)	6	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)					Melanoma(20;305 879 2501 4818 31020)								0.427586	184.823207	185.486838	62	83	GG		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(47;0.00185)		Missense_Mutation	SNP	120667626	120667626	5323	8	G	A	A	40	40	ENPP2	A	1	1
INTS10	55174	broad.mit.edu	36	8	19735084	19735084	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:19735084C>T	uc003wzj.1	+	c.1502C>T	c.(1501-1503)ACG>ATG	p.T501M		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	501					snRNA processing	integrator complex	protein binding			ovary(1)	1														0.554054	127.888947	128.079143	41	33	CC		KEEP	---	---	---	---	capture		Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)	Missense_Mutation	SNP	19735084	19735084	8077	8	C	T	T	19	19	INTS10	T	1	1
ZMAT1	84460	broad.mit.edu	36	X	101028358	101028358	+	Missense_Mutation	SNP	T	G	G			TCGA-19-2619-01	TCGA-19-2619-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chrX:101028358T>G	uc004eio.1	-	c.799A>C	c.(799-801)ATT>CTT	p.I267L	ZMAT1_uc010nnw.1_Silent_p.A169A|ZMAT1_uc004ein.1_5'UTR|ZMAT1_uc004eim.1_5'UTR	NM_032441	NP_115817	A7MD47	A7MD47_HUMAN	zinc finger, matrin type 1 isoform 3	Error:Variant_position_missing_in_A7MD47_after_alignment						nucleus	zinc ion binding			ovary(1)	1														0.382716	101.503342	102.481094	31	50	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	101028358	101028358	18282	23	T	G	G	51	51	ZMAT1	G	4	4
DOCK11	139818	broad.mit.edu	36	X	117606127	117606127	+	Splice_Site_SNP	SNP	G	T	T			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:117606127G>T	uc004eqp.2	+	c.1796_splice	c.e17-1	p.N599_splice	DOCK11_uc004eqq.2_Splice_Site_SNP_p.N365_splice	NM_144658	NP_653259			dedicator of cytokinesis 11						blood coagulation	cytosol	GTP binding			ovary(3)	3														0.416107	181.117525	182.034605	62	87	GG		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	117606127	117606127	4870	23	G	T	T	33	33	DOCK11	T	5	3
RNF113A	7737	broad.mit.edu	36	X	118888937	118888937	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:118888937C>T	uc004esb.1	-	c.668G>A	c.(667-669)CGT>CAT	p.R223H	NDUFA1_uc004esc.2_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	223	C3H1-type.						nucleic acid binding|zinc ion binding			breast(2)	2														0.441315	273.406972	274.047825	94	119	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	118888937	118888937	13904	23	C	T	T	19	19	RNF113A	T	1	1
ARHGAP36	158763	broad.mit.edu	36	X	130048257	130048257	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:130048257C>T	uc004evz.1	+	c.1423C>T	c.(1423-1425)CCA>TCA	p.P475S	ARHGAP36_uc004ewa.1_Missense_Mutation_p.P463S|ARHGAP36_uc004ewb.1_Missense_Mutation_p.P444S|ARHGAP36_uc004ewc.1_Missense_Mutation_p.P339S	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763	475					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3														0.423077	267.671275	268.743682	88	120	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	130048257	130048257	895	23	C	T	T	30	30	ARHGAP36	T	2	2
CTAG2	30848	broad.mit.edu	36	X	153534949	153534949	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:153534949G>A	uc004fmi.1	-	c.35C>T	c.(34-36)ACG>ATG	p.T12M	CTAG2_uc004fmh.1_Missense_Mutation_p.T12M	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	12	Gly-rich.					centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)													0.777778	22.93087	23.571969	7	2	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	153534949	153534949	4150	23	G	A	A	40	40	CTAG2	A	1	1
NHS	4810	broad.mit.edu	36	X	17655533	17655533	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:17655533C>T	uc004cxx.1	+	c.3323C>T	c.(3322-3324)CCG>CTG	p.P1108L	NHS_uc004cxy.1_Missense_Mutation_p.P952L|NHS_uc004cxz.1_Missense_Mutation_p.P931L|NHS_uc004cya.1_Missense_Mutation_p.P831L	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1108						nucleus				ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6	Hepatocellular(33;0.183)													0.410448	339.9147	341.78791	110	158	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	17655533	17655533	10811	23	C	T	T	23	23	NHS	T	1	1
TIMM17B	10245	broad.mit.edu	36	X	48636040	48636040	+	Silent	SNP	G	A	A			TCGA-19-2619-01	TCGA-19-2619-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:48636040G>A	uc004dla.1	-	c.585C>T	c.(583-585)CCC>CCT	p.P195P	TIMM17B_uc004dlb.1_Silent_p.P165P|TIMM17B_uc004dlc.1_Silent_p.P145P	NM_005834	NP_005825	O60830	TI17B_HUMAN	translocase of inner mitochondrial membrane 17	145					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1														0.416667	29.143338	29.28936	10	14	GG		KEEP	---	---	---	---	capture			Silent	SNP	48636040	48636040	16438	23	G	A	A	43	43	TIMM17B	A	2	2
PCDH11X	27328	broad.mit.edu	36	X	91019641	91019641	+	Missense_Mutation	SNP	C	A	A			TCGA-19-2619-01	TCGA-19-2619-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:91019641C>A	uc004efk.1	+	c.1746C>A	c.(1744-1746)AAC>AAA	p.N582K	PCDH11X_uc004efl.1_Missense_Mutation_p.N582K|PCDH11X_uc004efn.1_Missense_Mutation_p.N582K|PCDH11X_uc004efo.1_Missense_Mutation_p.N582K|PCDH11X_uc010nmv.1_Missense_Mutation_p.N582K|PCDH11X_uc004efm.1_Missense_Mutation_p.N582K|PCDH11X_uc004efh.1_Missense_Mutation_p.N582K|PCDH11X_uc004efj.1_Missense_Mutation_p.N582K	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	582	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						NSCLC(38;925 1092 2571 38200 45895)								0.39779	209.783992	211.428199	72	109	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	91019641	91019641	11928	23	C	A	A	18	18	PCDH11X	A	3	3
FAM174B	400451	broad.mit.edu	36	15	90999683	90999688	+	In_Frame_Del	DEL	TGGAGC	-	-			TCGA-19-2619-01	TCGA-19-2619-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:90999683_90999688delTGGAGC	uc010boe.1	-	c.206_211delGCTCCA	c.(205-213)AGCTCCAAC>AAC	p.SS69del	FAM174B_uc002bsl.2_Intron	NM_207446	NP_997329	Q3ZCQ3	F174B_HUMAN	hypothetical protein LOC400451	69_70	Extracellular (Potential).					integral to membrane					0														0.33			2	4				---	---	---	---	capture_indel			In_Frame_Del	DEL	90999683	90999688	5702	15	TGGAGC	-	-	63	63	FAM174B	-	5	5
CHD2	1106	broad.mit.edu	36	15	91368836	91368838	+	In_Frame_Del	DEL	CTC	-	-			TCGA-19-2619-01	TCGA-19-2619-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:91368836_91368838delCTC	uc002bsp.1	+	c.5384_5386delCTC	c.(5383-5388)TCTCCT>TCT	p.P1796del		NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1796					chromatin assembly or disassembly|regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	ATP binding|ATP-dependent DNA helicase activity|chromatin binding|DNA binding			ovary(1)	1	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)											0.40			48	72				---	---	---	---	capture_indel			In_Frame_Del	DEL	91368836	91368838	3459	15	CTC	-	-	32	32	CHD2	-	5	5
MYH15	22989	broad.mit.edu	36	3	109688022	109688022	+	Frame_Shift_Del	DEL	A	-	-			TCGA-19-2619-01	TCGA-19-2619-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:109688022_109688022delA	uc003dxa.1	-	c.973_973delT	c.(973-975)TGCfs	p.C325fs		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	325	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7														0.46			25	29				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	109688022	109688022	10429	3	A	-	-	5	5	MYH15	-	5	5
