Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
GABRD	2563	broad.mit.edu	37	1	1961728	1961728	+	3'UTR	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1961728G>T	uc001aip.2	+	9						NM_000815	NP_000806	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta							cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GTGAGCACAGGACTCAGGCCA	0.632													33	38	---	---	---	---	PASS
HIVEP3	59269	broad.mit.edu	37	1	42048314	42048314	+	Nonsense_Mutation	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:42048314T>A	uc001cgz.3	-	4	3368	c.2155A>T	c.(2155-2157)AAG>TAG	p.K719*	HIVEP3_uc001cha.3_Nonsense_Mutation_p.K719*|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	719	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CCAAGGCTCTTCTCTTTCCTC	0.537													53	42	---	---	---	---	PASS
PTPRF	5792	broad.mit.edu	37	1	44019608	44019608	+	Silent	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44019608C>G	uc001cjr.2	+	5	715	c.375C>G	c.(373-375)CTC>CTG	p.L125L	PTPRF_uc001cjq.3_Silent_p.L125L|PTPRF_uc001cjs.2_Silent_p.L125L|PTPRF_uc001cjt.3_Silent_p.L125L	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	125	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TCTCAGTGCTCGAAGGTACGT	0.597													14	36	---	---	---	---	PASS
TOE1	114034	broad.mit.edu	37	1	45805976	45805976	+	Missense_Mutation	SNP	G	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45805976G>C	uc009vxq.2	+	1	635	c.52G>C	c.(52-54)GGT>CGT	p.G18R	MUTYH_uc001cnf.2_5'Flank|MUTYH_uc009vxo.2_5'Flank|MUTYH_uc001cng.2_5'Flank|MUTYH_uc001cnj.2_5'Flank|MUTYH_uc001cni.2_5'Flank|MUTYH_uc001cnh.2_5'Flank|MUTYH_uc001cno.2_5'UTR|MUTYH_uc001cnk.2_5'UTR|MUTYH_uc010oll.1_5'UTR|MUTYH_uc001cnm.2_5'UTR|MUTYH_uc001cnl.2_5'UTR|MUTYH_uc009vxp.2_5'UTR|MUTYH_uc001cnn.2_5'UTR|TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Missense_Mutation_p.G18R|TOE1_uc010oln.1_Missense_Mutation_p.G18R|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	18						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGCTTCCGACGGTGAGCGGCT	0.627													10	15	---	---	---	---	PASS
GBP4	115361	broad.mit.edu	37	1	89658722	89658722	+	Missense_Mutation	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89658722C>G	uc001dnb.2	-	5	651	c.535G>C	c.(535-537)GAG>CAG	p.E179Q		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	179						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		CTGGAGTCCTCAGCTTCATCA	0.483													5	140	---	---	---	---	PASS
GBP4	115361	broad.mit.edu	37	1	89658731	89658731	+	Missense_Mutation	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89658731C>G	uc001dnb.2	-	5	642	c.526G>C	c.(526-528)GAT>CAT	p.D176H		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	176						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		TCAGCTTCATCAGGTCTGGGG	0.478													4	142	---	---	---	---	PASS
AKNAD1	254268	broad.mit.edu	37	1	109394998	109394998	+	Missense_Mutation	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109394998T>A	uc001dwa.2	-	2	558	c.289A>T	c.(289-291)ATT>TTT	p.I97F	AKNAD1_uc010ovb.1_Intron|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	97										ovary(3)	3						TTTGCTGGAATATGAAGAGCT	0.393													73	86	---	---	---	---	PASS
CSF1	1435	broad.mit.edu	37	1	110466216	110466216	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110466216C>T	uc001dyu.2	+	6	1386	c.973C>T	c.(973-975)CCC>TCC	p.P325S	CSF1_uc001dyt.2_Missense_Mutation_p.P325S|CSF1_uc001dyv.3_Intron|CSF1_uc001dyw.3_Missense_Mutation_p.P325S	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	325	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGAGCTTTCCCCCTCCAGGCC	0.582											OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	109	---	---	---	---	PASS
ATP1A1	476	broad.mit.edu	37	1	116940528	116940528	+	Silent	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:116940528A>T	uc001ege.2	+	15	2331	c.1992A>T	c.(1990-1992)GTA>GTT	p.V664V	ATP1A1_uc010owv.1_Silent_p.V633V|ATP1A1_uc010oww.1_Silent_p.V664V|ATP1A1_uc010owx.1_Silent_p.V633V|C1orf203_uc009whb.2_Intron|ATP1A1_uc001egh.2_5'Flank	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	664	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	AGGCCTGCGTAGTACACGGCA	0.468													83	81	---	---	---	---	PASS
RPTN	126638	broad.mit.edu	37	1	152129183	152129183	+	Missense_Mutation	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152129183T>A	uc001ezs.1	-	3	457	c.392A>T	c.(391-393)AAC>ATC	p.N131I		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	131	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						GTGGTGGGAGTTCTGCCTTTC	0.527													66	499	---	---	---	---	PASS
C1orf114	57821	broad.mit.edu	37	1	169366527	169366527	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169366527C>T	uc001gga.1	-	5	1486	c.1318G>A	c.(1318-1320)GAA>AAA	p.E440K	C1orf114_uc001gfz.1_Missense_Mutation_p.E439K|C1orf114_uc009wvq.1_Missense_Mutation_p.E439K	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	440											0	all_hematologic(923;0.208)					AATAAACATTCCTCTTGCTTT	0.418													23	88	---	---	---	---	PASS
PM20D1	148811	broad.mit.edu	37	1	205814506	205814506	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205814506G>A	uc001hdj.2	-	3	481	c.436C>T	c.(436-438)CGT>TGT	p.R146C	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	146						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			ATGCCATCACGCTCCAACCCA	0.572													67	149	---	---	---	---	PASS
SRGAP2	23380	broad.mit.edu	37	1	206619426	206619426	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206619426C>T	uc001hdy.2	+	15	1952	c.1619C>T	c.(1618-1620)TCA>TTA	p.S540L	SRGAP2_uc010prt.1_Missense_Mutation_p.S463L|SRGAP2_uc001hdx.2_Missense_Mutation_p.S540L|SRGAP2_uc010pru.1_Missense_Mutation_p.S463L|SRGAP2_uc010prv.1_Missense_Mutation_p.S464L	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	627	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					TCCAGTTTATCACAGTTCAGT	0.547													23	75	---	---	---	---	PASS
RD3	343035	broad.mit.edu	37	1	211654707	211654707	+	Silent	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:211654707G>A	uc001him.2	-	2	1215	c.51C>T	c.(49-51)TCC>TCT	p.S17S	RD3_uc001hin.2_RNA|RD3_uc009xda.2_Intron	NM_183059	NP_898882	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	17					response to stimulus|visual perception					ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		GGCTCCTGGTGGACAGCCGGG	0.632													43	113	---	---	---	---	PASS
TLR5	7100	broad.mit.edu	37	1	223285747	223285747	+	Nonsense_Mutation	SNP	A	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223285747A>C	uc001hnv.1	-	4	1073	c.627T>G	c.(625-627)TAT>TAG	p.Y209*	TLR5_uc001hnw.1_Nonsense_Mutation_p.Y209*	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	209	Extracellular (Potential).				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		AGACTCTGCTATACAAGCTAT	0.443													15	150	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237947700	237947700	+	Missense_Mutation	SNP	G	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237947700G>C	uc001hyl.1	+	90	12808	c.12688G>C	c.(12688-12690)GGG>CGG	p.G4230R	RYR2_uc010pya.1_Missense_Mutation_p.G645R	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4230					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAAGAGCAGGGGCCGAGGAT	0.537													17	51	---	---	---	---	PASS
FMN2	56776	broad.mit.edu	37	1	240370312	240370312	+	Silent	SNP	C	A	A	rs145706266	byFrequency	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240370312C>A	uc010pyd.1	+	5	2425	c.2200C>A	c.(2200-2202)CGG>AGG	p.R734R	FMN2_uc010pye.1_Silent_p.R738R	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	734					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAAGGAAGTACGGCATCATAG	0.562													6	92	---	---	---	---	PASS
LRPPRC	10128	broad.mit.edu	37	2	44161358	44161358	+	Missense_Mutation	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44161358T>A	uc002rtr.2	-	25	2765	c.2707A>T	c.(2707-2709)AAT>TAT	p.N903Y	LRPPRC_uc010yob.1_Missense_Mutation_p.N803Y	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	903					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCTTTGTAATTTCCTGTTTGT	0.338													41	66	---	---	---	---	PASS
NRXN1	9378	broad.mit.edu	37	2	50464081	50464081	+	Missense_Mutation	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:50464081C>G	uc010fbp.2	-	2	1094	c.287G>C	c.(286-288)GGT>GCT	p.G96A	NRXN1_uc002rxb.3_Missense_Mutation_p.G803A|NRXN1_uc010fbq.2_Missense_Mutation_p.G1171A|NRXN1_uc002rxe.3_Missense_Mutation_p.G1131A|NRXN1_uc002rxc.1_RNA	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	96	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TTGTCCACCACCTTTGCTAAA	0.428													11	170	---	---	---	---	PASS
DYSF	8291	broad.mit.edu	37	2	71886094	71886094	+	Silent	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71886094C>G	uc002sie.2	+	43	5101	c.4725C>G	c.(4723-4725)CCC>CCG	p.P1575P	DYSF_uc010feg.2_Silent_p.P1606P|DYSF_uc010feh.2_Silent_p.P1582P|DYSF_uc002sig.3_Silent_p.P1561P|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.P1596P|DYSF_uc010fef.2_Silent_p.P1613P|DYSF_uc010fei.2_Silent_p.P1592P|DYSF_uc010fek.2_Silent_p.P1593P|DYSF_uc010fej.2_Silent_p.P1583P|DYSF_uc010fel.2_Silent_p.P1562P|DYSF_uc010feo.2_Silent_p.P1607P|DYSF_uc010fem.2_Silent_p.P1597P|DYSF_uc010fen.2_Silent_p.P1614P|DYSF_uc002sif.2_Silent_p.P1576P|DYSF_uc010yqy.1_Silent_p.P456P|DYSF_uc010yqz.1_Silent_p.P336P	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1575	Cytoplasmic (Potential).|C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CCCAGGGACCCCAGGAGTGCT	0.572													33	230	---	---	---	---	PASS
LRRTM4	80059	broad.mit.edu	37	2	77746266	77746266	+	Silent	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:77746266G>A	uc002snr.2	-	3	1144	c.729C>T	c.(727-729)TCC>TCT	p.S243S	LRRTM4_uc002snq.2_Silent_p.S243S|LRRTM4_uc002sns.2_Silent_p.S243S|LRRTM4_uc002snt.2_Silent_p.S244S	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	243	LRR 8.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CTTGGCTAATGGAGCGAATCC	0.448													8	50	---	---	---	---	PASS
CNTNAP5	129684	broad.mit.edu	37	2	125175047	125175047	+	Missense_Mutation	SNP	A	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:125175047A>C	uc002tno.2	+	4	773	c.409A>C	c.(409-411)AGC>CGC	p.S137R	CNTNAP5_uc010flu.2_Missense_Mutation_p.S137R	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	137	F5/8 type C.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GAATGCTGACAGCGTGGTGCA	0.483													8	58	---	---	---	---	PASS
TUBA3D	113457	broad.mit.edu	37	2	132238108	132238108	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132238108C>T	uc002tsu.3	+	4	949	c.842C>T	c.(841-843)GCC>GTC	p.A281V		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	281					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		GCTGAGAAGGCCTACCACGAG	0.582													142	113	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141283440	141283440	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141283440C>A	uc002tvj.1	-	49	8971	c.7999G>T	c.(7999-8001)GAC>TAC	p.D2667Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2667	Extracellular (Potential).|LDL-receptor class A 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTGAATAGTCTCCACAGTCA	0.413										TSP Lung(27;0.18)			63	61	---	---	---	---	PASS
PDE1A	5136	broad.mit.edu	37	2	183104928	183104928	+	Silent	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183104928G>T	uc002uos.2	-	4	391	c.307C>A	c.(307-309)CGG>AGG	p.R103R	PDE1A_uc010zfp.1_5'UTR|PDE1A_uc002uoq.1_Silent_p.R103R|PDE1A_uc010zfq.1_Silent_p.R103R|PDE1A_uc002uor.2_Silent_p.R87R|PDE1A_uc002uou.2_Silent_p.R69R	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	103					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			CCCATTTTCCGTGTAAAGGTA	0.423													117	207	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	186678704	186678704	+	RNA	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:186678704A>T	uc002upm.2	+	2		c.3342A>T			uc010zfu.1_Missense_Mutation_p.M1252L					Homo sapiens cDNA FLJ44048 fis, clone TESTI4030669.																		TGAGCTTGACATGGCCACACC	0.438													63	152	---	---	---	---	PASS
PARD3B	117583	broad.mit.edu	37	2	206480528	206480528	+	Silent	SNP	A	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:206480528A>G	uc002var.1	+	23	3816	c.3609A>G	c.(3607-3609)GCA>GCG	p.A1203A	PARD3B_uc002vao.1_Silent_p.A1102A|PARD3B_uc002vap.1_Silent_p.A1141A|PARD3B_uc002vaq.1_Silent_p.A1134A|uc010fuc.1_5'Flank	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	1203					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CCATGACTGCAGCCGTATAGC	0.587													66	67	---	---	---	---	PASS
GIGYF2	26058	broad.mit.edu	37	2	233652049	233652049	+	Intron	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233652049C>T	uc002vti.3	+						GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.3_Intron|GIGYF2_uc002vtk.3_Intron|GIGYF2_uc002vth.3_Intron|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc010zml.1_Intron	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b						cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GGTAAGAATTCTGTTGAGTAA	0.438													42	20	---	---	---	---	PASS
SATB1	6304	broad.mit.edu	37	3	18436276	18436276	+	Missense_Mutation	SNP	G	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:18436276G>C	uc003cbh.2	-	7	2619	c.884C>G	c.(883-885)TCT>TGT	p.S295C	SATB1_uc003cbi.2_Missense_Mutation_p.S295C|SATB1_uc003cbj.2_Missense_Mutation_p.S295C	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	295					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						TGTCCGGACAGAGGGCTGGCT	0.582													43	50	---	---	---	---	PASS
NT5DC2	64943	broad.mit.edu	37	3	52562310	52562310	+	Silent	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52562310C>T	uc003deo.2	-	6	973	c.549G>A	c.(547-549)CAG>CAA	p.Q183Q	NT5DC2_uc003dem.2_Silent_p.Q53Q|NT5DC2_uc003den.2_Silent_p.Q220Q|NT5DC2_uc010hmi.2_Silent_p.Q195Q|NT5DC2_uc010hmj.2_5'UTR	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	183							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		TGTCCATGAACTGCTTAATGG	0.572													49	69	---	---	---	---	PASS
MAGI1	9223	broad.mit.edu	37	3	65342499	65342499	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:65342499C>T	uc003dmn.2	-	23	4469	c.3943G>A	c.(3943-3945)GCC>ACC	p.A1315T	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1344	Poly-Ala.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GGGCCGTTGGCGGCTGCCGCG	0.697													3	32	---	---	---	---	PASS
MAGI1	9223	broad.mit.edu	37	3	65367554	65367554	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:65367554G>A	uc003dmn.2	-	16	3225	c.2699C>T	c.(2698-2700)GCG>GTG	p.A900V	MAGI1_uc003dmm.2_Missense_Mutation_p.A928V|MAGI1_uc003dmo.2_Missense_Mutation_p.A928V|MAGI1_uc003dmp.2_Missense_Mutation_p.A900V|MAGI1_uc003dmq.1_5'Flank|MAGI1_uc010hnx.1_Missense_Mutation_p.A211V	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	928					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		ATACATACCCGCAAAAACCAC	0.473													11	52	---	---	---	---	PASS
ARHGAP31	57514	broad.mit.edu	37	3	119120970	119120970	+	Silent	SNP	G	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119120970G>C	uc003ecj.3	+	10	1903	c.1371G>C	c.(1369-1371)TCG>TCC	p.S457S		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	457					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						TCTACACTTCGAACGACAGCC	0.592													64	129	---	---	---	---	PASS
ZIC4	84107	broad.mit.edu	37	3	147114021	147114021	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:147114021G>T	uc003ewd.1	-	3	579	c.306C>A	c.(304-306)AAC>AAA	p.N102K	ZIC4_uc003ewc.1_Missense_Mutation_p.N32K|ZIC4_uc011bno.1_Missense_Mutation_p.N152K	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	102						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						TCACCGTCAGGTTCATGCCCC	0.697													19	43	---	---	---	---	PASS
SLC7A14	57709	broad.mit.edu	37	3	170185011	170185011	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170185011G>T	uc003fgz.2	-	8	2464	c.2148C>A	c.(2146-2148)AGC>AGA	p.S716R	CLDN11_uc011bpt.1_Intron|uc003fha.1_5'Flank	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	716						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AGTCCTCCTGGCTCTCGCCCT	0.577													22	232	---	---	---	---	PASS
ZNF721	170960	broad.mit.edu	37	4	436622	436622	+	Missense_Mutation	SNP	T	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:436622T>C	uc003gag.2	-	3	2325	c.1634A>G	c.(1633-1635)TAT>TGT	p.Y545C	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.Y577C|ZNF721_uc010ibe.2_Missense_Mutation_p.Y533C	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	545						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CCTATGTACATAAAGGATTGC	0.403													104	112	---	---	---	---	PASS
ZBTB49	166793	broad.mit.edu	37	4	4304558	4304558	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:4304558G>A	uc003ghu.2	+	3	1170	c.995G>A	c.(994-996)GGT>GAT	p.G332D	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Missense_Mutation_p.G32D	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TCAGATGATGGTTTGACAAAG	0.418													45	46	---	---	---	---	PASS
PCDH7	5099	broad.mit.edu	37	4	30724309	30724309	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:30724309G>A	uc003gsk.1	+	1	2273	c.1265G>A	c.(1264-1266)CGC>CAC	p.R422H	PCDH7_uc011bxw.1_Missense_Mutation_p.R375H|PCDH7_uc011bxx.1_Missense_Mutation_p.R422H	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	422	Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AAGATTGGGCGCATCCCCCTC	0.627													3	67	---	---	---	---	PASS
ODZ3	55714	broad.mit.edu	37	4	183594205	183594205	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183594205G>A	uc003ivd.1	+	6	1196	c.1159G>A	c.(1159-1161)GAA>AAA	p.E387K		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	387	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGATTCCGGAGAACTTGATAT	0.358													5	16	---	---	---	---	PASS
CDH6	1004	broad.mit.edu	37	5	31305407	31305407	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31305407G>T	uc003jhe.1	+	7	1452	c.1126G>T	c.(1126-1128)GAT>TAT	p.D376Y	CDH6_uc003jhd.1_Missense_Mutation_p.D376Y	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	376	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGTGGTGGAGGATGTAGATGA	0.458													50	132	---	---	---	---	PASS
ADAMTS12	81792	broad.mit.edu	37	5	33549443	33549443	+	Missense_Mutation	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33549443A>T	uc003jia.1	-	21	4334	c.4171T>A	c.(4171-4173)TGC>AGC	p.C1391S	ADAMTS12_uc010iuq.1_Missense_Mutation_p.C1306S	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1391	TSP type-1 6.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTGTCCACGCACTGAATCTCG	0.572										HNSCC(64;0.19)			41	202	---	---	---	---	PASS
CKMT2	1160	broad.mit.edu	37	5	80548572	80548572	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80548572G>A	uc003khc.3	+	4	453	c.211G>A	c.(211-213)GCC>ACC	p.A71T	RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Missense_Mutation_p.A71T|CKMT2_uc003khd.3_Missense_Mutation_p.A71T|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816	P17540	KCRS_HUMAN	sarcomeric mitochondrial creatine kinase	71	Phosphagen kinase N-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	CCTCACCCCCGCCATTTATGC	0.612													53	51	---	---	---	---	PASS
CKMT2	1160	broad.mit.edu	37	5	80548574	80548574	+	Silent	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80548574C>A	uc003khc.3	+	4	455	c.213C>A	c.(211-213)GCC>GCA	p.A71A	RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Silent_p.A71A|CKMT2_uc003khd.3_Silent_p.A71A|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816	P17540	KCRS_HUMAN	sarcomeric mitochondrial creatine kinase	71	Phosphagen kinase N-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	TCACCCCCGCCATTTATGCCA	0.612													51	54	---	---	---	---	PASS
PCDHGA1	56114	broad.mit.edu	37	5	140710522	140710522	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140710522G>A	uc003lji.1	+	1	271	c.271G>A	c.(271-273)GAC>AAC	p.D91N	PCDHGA1_uc011dan.1_Missense_Mutation_p.D91N	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	91	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCAGGATAGACCGGGAGGA	0.512													8	249	---	---	---	---	PASS
GRIA1	2890	broad.mit.edu	37	5	153078581	153078581	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153078581G>A	uc003lva.3	+	10	1765	c.1400G>A	c.(1399-1401)CGA>CAA	p.R467Q	GRIA1_uc003luy.3_Missense_Mutation_p.R467Q|GRIA1_uc003luz.3_Missense_Mutation_p.R372Q|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.R387Q|GRIA1_uc011dcx.1_Missense_Mutation_p.R398Q|GRIA1_uc011dcy.1_Missense_Mutation_p.R477Q|GRIA1_uc011dcz.1_Missense_Mutation_p.R477Q|GRIA1_uc010jia.1_Missense_Mutation_p.R447Q	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	467	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TACGGAGCCCGAGACCCTGAC	0.562													20	34	---	---	---	---	PASS
MYLK4	340156	broad.mit.edu	37	6	2689078	2689078	+	Intron	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:2689078T>A	uc003mty.3	-							NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4								ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				CATTCAGCCTTACTCACCCTC	0.443													163	318	---	---	---	---	PASS
NEDD9	4739	broad.mit.edu	37	6	11185599	11185599	+	Silent	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:11185599C>T	uc003mzv.2	-	7	2468	c.2301G>A	c.(2299-2301)GTG>GTA	p.V767V	NEDD9_uc010joz.2_Silent_p.V767V|NEDD9_uc003mzw.3_Silent_p.V621V	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	767					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			CCTGGGCAGTCACCTGCCGTG	0.557													7	199	---	---	---	---	PASS
EYS	346007	broad.mit.edu	37	6	66205194	66205194	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:66205194G>A	uc011dxu.1	-	4	648	c.110C>T	c.(109-111)TCA>TTA	p.S37L	EYS_uc003peq.2_Missense_Mutation_p.S37L|EYS_uc003per.1_Missense_Mutation_p.S37L|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	37					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CACATATGATGAGGGTTGTGG	0.393													7	279	---	---	---	---	PASS
MARCKS	4082	broad.mit.edu	37	6	114181255	114181255	+	Missense_Mutation	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:114181255A>T	uc003pvy.3	+	2	894	c.499A>T	c.(499-501)AGC>TGC	p.S167C		NM_002356	NP_002347	P29966	MARCS_HUMAN	myristoylated alanine-rich protein kinase C	167	Calmodulin-binding (PSD).				energy reserve metabolic process|regulation of insulin secretion	actin cytoskeleton|plasma membrane	actin filament binding|calmodulin binding				0		all_cancers(87;7.65e-05)|all_epithelial(87;0.000296)|all_hematologic(75;0.0172)|Colorectal(196;0.0317)|all_lung(197;0.198)		Epithelial(106;1.59e-07)|all cancers(137;9.85e-07)|OV - Ovarian serous cystadenocarcinoma(136;0.000322)		TTTCAAGCTGAGCGGCTTCTC	0.493													19	33	---	---	---	---	PASS
GRM1	2911	broad.mit.edu	37	6	146480556	146480556	+	Missense_Mutation	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146480556C>G	uc010khw.1	+	3	1243	c.773C>G	c.(772-774)TCT>TGT	p.S258C	GRM1_uc010khu.1_Missense_Mutation_p.S258C|GRM1_uc010khv.1_Missense_Mutation_p.S258C|GRM1_uc003qll.2_Missense_Mutation_p.S258C|GRM1_uc011edz.1_Missense_Mutation_p.S258C|GRM1_uc011eea.1_Missense_Mutation_p.S258C	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	258	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATCGCCCATTCTGACAAAATC	0.527													23	148	---	---	---	---	PASS
C6orf72	116254	broad.mit.edu	37	6	149903651	149903651	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:149903651C>T	uc003qmq.1	+	7	820	c.793C>T	c.(793-795)CAG>TAG	p.Q265*		NM_138785	NP_620140	Q9NU53	CF072_HUMAN	hypothetical protein LOC116254 precursor	265	Extracellular (Potential).					integral to membrane					0		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;9.66e-12)|GBM - Glioblastoma multiforme(68;0.171)		AGTATTCTTTCAGTTTTTGAA	0.363													6	320	---	---	---	---	PASS
GLI3	2737	broad.mit.edu	37	7	42005902	42005902	+	Silent	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:42005902G>A	uc011kbh.1	-	15	2860	c.2769C>T	c.(2767-2769)CCC>CCT	p.P923P	GLI3_uc011kbg.1_Silent_p.P864P	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	923					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ACTGCTGGGCGGGCGTGAGGC	0.716									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				7	16	---	---	---	---	PASS
TNS3	64759	broad.mit.edu	37	7	47408322	47408322	+	Missense_Mutation	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:47408322C>G	uc003tnv.2	-	17	2288	c.1921G>C	c.(1921-1923)GTG>CTG	p.V641L	TNS3_uc003tnw.2_Missense_Mutation_p.V641L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	641						focal adhesion	protein binding			ovary(4)	4						TGGACAGCCACCCTACTGCTG	0.662													41	166	---	---	---	---	PASS
BAZ1B	9031	broad.mit.edu	37	7	72892464	72892464	+	Missense_Mutation	SNP	T	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72892464T>C	uc003tyc.2	-	7	1672	c.1327A>G	c.(1327-1329)ATG>GTG	p.M443V		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	443	Lys-rich.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				CCTTTGGCCATATCCAACAAA	0.478													74	232	---	---	---	---	PASS
TBL2	26608	broad.mit.edu	37	7	72987813	72987813	+	Intron	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72987813C>G	uc003tyh.2	-						TBL2_uc011kex.1_Intron|TBL2_uc010lbg.2_Intron|TBL2_uc003tyi.2_Intron|TBL2_uc011key.1_Intron|TBL2_uc010lbh.2_Intron	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2												0		Lung NSC(55;0.0659)|all_lung(88;0.152)				TAGAGACAGGCAGCAGACAAG	0.582													51	99	---	---	---	---	PASS
LRRN3	54674	broad.mit.edu	37	7	110763554	110763554	+	Silent	SNP	T	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:110763554T>G	uc003vft.3	+	4	1772	c.726T>G	c.(724-726)TCT>TCG	p.S242S	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.S242S|LRRN3_uc003vfs.3_Silent_p.S242S	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	242	Extracellular (Potential).|LRR 8.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		AAAGCATCTCTTTTTACGATA	0.348													65	123	---	---	---	---	PASS
CFTR	1080	broad.mit.edu	37	7	117232171	117232171	+	Silent	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117232171C>T	uc003vjd.2	+	14	2082	c.1950C>T	c.(1948-1950)TTC>TTT	p.F650F	CFTR_uc011knq.1_Silent_p.F56F	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	650	Cytoplasmic (Potential).				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GTGATTCTTTCGACCAATTTA	0.383									Cystic_Fibrosis				9	143	---	---	---	---	PASS
CCDC136	64753	broad.mit.edu	37	7	128452070	128452070	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128452070G>A	uc003vnv.1	+	13	2612	c.2245G>A	c.(2245-2247)GGT>AGT	p.G749S	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Intron|CCDC136_uc003vnx.1_Missense_Mutation_p.G565S|CCDC136_uc010llq.1_Missense_Mutation_p.G118S|CCDC136_uc003vny.1_Missense_Mutation_p.G359S	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	749						integral to membrane	protein binding			ovary(2)	2						GAAGAGCTATGGTAGCATGGT	0.498													50	127	---	---	---	---	PASS
FLNC	2318	broad.mit.edu	37	7	128494225	128494225	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128494225C>T	uc003vnz.3	+	40	6891	c.6682C>T	c.(6682-6684)CGG>TGG	p.R2228W	FLNC_uc003voa.3_Missense_Mutation_p.R2195W	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2228	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CTTCCTGGGCCGGGAGCGCCT	0.716													9	33	---	---	---	---	PASS
AHCYL2	23382	broad.mit.edu	37	7	129040166	129040166	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129040166G>A	uc011kov.1	+	6	913	c.859G>A	c.(859-861)GAT>AAT	p.D287N	AHCYL2_uc003vot.2_Missense_Mutation_p.D286N|AHCYL2_uc003vov.2_Missense_Mutation_p.D184N|AHCYL2_uc011kow.1_Missense_Mutation_p.D185N|AHCYL2_uc011kox.1_Missense_Mutation_p.D184N	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	287					one-carbon metabolic process		adenosylhomocysteinase activity	p.D287G(1)		ovary(2)	2						AGAGTCAGAAGATGACTTTTG	0.448													63	118	---	---	---	---	PASS
TAS2R41	259287	broad.mit.edu	37	7	143175723	143175723	+	Missense_Mutation	SNP	A	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143175723A>G	uc003wdc.1	+	1	758	c.758A>G	c.(757-759)GAT>GGT	p.D253G	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	253	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					CTGATCATTGATGCCGCAAAA	0.498													55	137	---	---	---	---	PASS
GIMAP8	155038	broad.mit.edu	37	7	150174631	150174631	+	Silent	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150174631T>A	uc003whj.2	+	5	2091	c.1761T>A	c.(1759-1761)CTT>CTA	p.L587L		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	587						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ACAAAGCCCTTCGGCGCATTT	0.468													74	162	---	---	---	---	PASS
CLN8	2055	broad.mit.edu	37	8	1728668	1728668	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:1728668G>T	uc003wpo.3	+	3	1101	c.796G>T	c.(796-798)GCA>TCA	p.A266S		NM_018941	NP_061764	Q9UBY8	CLN8_HUMAN	ceroid-lipofuscinosis, neuronal 8	266					cell death|ceramide biosynthetic process|cholesterol metabolic process|lipid transport|negative regulation of proteolysis|phospholipid metabolic process	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.67e-05)|READ - Rectum adenocarcinoma(644;0.0913)		CTGGAACTTCGCACAGCCAGA	0.577													65	153	---	---	---	---	PASS
AMAC1L2	83650	broad.mit.edu	37	8	11189016	11189016	+	Missense_Mutation	SNP	G	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11189016G>C	uc003wtp.1	+	1	522	c.401G>C	c.(400-402)CGC>CCC	p.R134P		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	134	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		GCCACTGTTCGCAAAGGTTCT	0.607													70	168	---	---	---	---	PASS
AMAC1L2	83650	broad.mit.edu	37	8	11189017	11189017	+	Silent	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11189017C>T	uc003wtp.1	+	1	523	c.402C>T	c.(400-402)CGC>CGT	p.R134R		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	134	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		CCACTGTTCGCAAAGGTTCTT	0.607													71	172	---	---	---	---	PASS
DOCK5	80005	broad.mit.edu	37	8	25126369	25126369	+	Missense_Mutation	SNP	A	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25126369A>G	uc003xeg.2	+	3	273	c.136A>G	c.(136-138)AGA>GGA	p.R46G	DOCK5_uc010luf.1_RNA|DOCK5_uc003xef.2_Missense_Mutation_p.R46G	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	46	SH3.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		AGGTTGGTACAGAGGATATAC	0.299													5	22	---	---	---	---	PASS
RP1	6101	broad.mit.edu	37	8	55540872	55540872	+	Missense_Mutation	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:55540872A>T	uc003xsd.1	+	4	4578	c.4430A>T	c.(4429-4431)GAT>GTT	p.D1477V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1477					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CATGACACTGATATCTTTAAT	0.358													36	93	---	---	---	---	PASS
ASPH	444	broad.mit.edu	37	8	62577920	62577920	+	Intron	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62577920C>A	uc003xuj.2	-						ASPH_uc011leg.1_Intron|ASPH_uc003xuo.2_Intron|ASPH_uc011leh.1_Intron|ASPH_uc003xul.2_Intron|ASPH_uc011lei.1_Intron|ASPH_uc011lej.1_Intron|ASPH_uc003xun.2_Intron|ASPH_uc011lek.1_Intron|ASPH_uc003xum.2_Intron|ASPH_uc011lel.1_Missense_Mutation_p.D190Y|ASPH_uc011lem.1_Missense_Mutation_p.D175Y	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a						muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	ctagaaacatccttcatattt	0.134													44	132	---	---	---	---	PASS
TRPA1	8989	broad.mit.edu	37	8	72935258	72935258	+	Missense_Mutation	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:72935258A>T	uc003xza.2	-	27	3418	c.3243T>A	c.(3241-3243)GAT>GAA	p.D1081E	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	1081	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	AATGGCTATCATCATCCTCTG	0.398													45	106	---	---	---	---	PASS
HEY1	23462	broad.mit.edu	37	8	80677993	80677993	+	Silent	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:80677993C>T	uc003ybm.2	-	5	545	c.345G>A	c.(343-345)GCG>GCA	p.A115A	HEY1_uc010lzq.2_5'UTR|HEY1_uc003ybl.2_Silent_p.A119A	NM_012258	NP_036390	Q9Y5J3	HEY1_HUMAN	hairy/enhancer-of-split related with YRPW motif	115	Transcriptional repression and interaction with NCOR1 and SIN3A (By similarity).				angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding			lung(3)	3	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			CAAGGGCGTGCGCGTCAAAGT	0.488											OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	107	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113299462	113299462	+	Silent	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113299462C>A	uc003ynu.2	-	58	9321	c.9162G>T	c.(9160-9162)GGG>GGT	p.G3054G	CSMD3_uc003yns.2_Silent_p.G2256G|CSMD3_uc003ynt.2_Silent_p.G3014G|CSMD3_uc011lhx.1_Silent_p.G2885G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3054	Extracellular (Potential).|Sushi 22.					integral to membrane|plasma membrane		p.G3054E(1)		ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CGCCACATGTCCCAGTAGCAT	0.438										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			45	100	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113395831	113395831	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113395831C>A	uc003ynu.2	-	37	6155	c.5996G>T	c.(5995-5997)GGA>GTA	p.G1999V	CSMD3_uc003yns.2_Missense_Mutation_p.G1201V|CSMD3_uc003ynt.2_Missense_Mutation_p.G1959V|CSMD3_uc011lhx.1_Missense_Mutation_p.G1895V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1999	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATTGTTGTCTCCCCCATCATA	0.318										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			32	91	---	---	---	---	PASS
SH3GL2	6456	broad.mit.edu	37	9	17795590	17795590	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:17795590C>A	uc003zna.2	+	9	1196	c.908C>A	c.(907-909)CCT>CAT	p.P303H	SH3GL2_uc011lmy.1_Missense_Mutation_p.P256H	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	303	SH3.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GACTTTGAACCTGAAAATGAA	0.468													44	37	---	---	---	---	PASS
C9orf102	375748	broad.mit.edu	37	9	98683538	98683538	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98683538C>T	uc004avt.3	+	7	1661	c.1273C>T	c.(1273-1275)CAA>TAA	p.Q425*	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Nonsense_Mutation_p.Q127*|C9orf102_uc010mry.1_Nonsense_Mutation_p.Q127*|C9orf102_uc010mrz.2_Nonsense_Mutation_p.Q236*|C9orf102_uc004avu.2_5'Flank	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	425					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				TTTGATACTTCAATCTTCTGA	0.348													8	142	---	---	---	---	PASS
COL15A1	1306	broad.mit.edu	37	9	101778305	101778305	+	Silent	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101778305C>G	uc004azb.1	+	11	1757	c.1551C>G	c.(1549-1551)CCC>CCG	p.P517P		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	517	Nonhelical region 1 (NC1).|4.|4 X tandem repeats.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				CAGAGGAGCCCCTCATCACAG	0.592													16	34	---	---	---	---	PASS
OR1Q1	158131	broad.mit.edu	37	9	125377461	125377461	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125377461C>A	uc011lyy.1	+	1	445	c.445C>A	c.(445-447)CAT>AAT	p.H149N		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTCATGTGCCATGCTCTCTC	0.488													47	218	---	---	---	---	PASS
OR1L4	254973	broad.mit.edu	37	9	125487159	125487159	+	Silent	SNP	T	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125487159T>C	uc004bmu.1	+	1	891	c.891T>C	c.(889-891)GAT>GAC	p.D297D		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGAACAAAGATATGAAAAGGG	0.398													52	77	---	---	---	---	PASS
NUP188	23511	broad.mit.edu	37	9	131745571	131745571	+	Splice_Site	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131745571G>A	uc004bws.1	+	18	1819	c.1797_splice	c.e18-1	p.R599_splice	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TCTCCAACCAGGTTAACGACA	0.463													5	225	---	---	---	---	PASS
ADARB2	105	broad.mit.edu	37	10	1569074	1569074	+	Intron	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:1569074C>A	uc009xhq.2	-						uc001ign.2_Nonsense_Mutation_p.S36*	NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2						mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CTTGCCTCATCAGCCTCACAG	0.517													20	190	---	---	---	---	PASS
C10orf18	54906	broad.mit.edu	37	10	5803317	5803317	+	Missense_Mutation	SNP	G	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5803317G>C	uc001iij.2	+	19	7682	c.7057G>C	c.(7057-7059)GAA>CAA	p.E2353Q	C10orf18_uc001iik.2_Missense_Mutation_p.E1197Q	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2353										ovary(1)|central_nervous_system(1)	2						AAATATCATTGAATTGCTTCA	0.338													7	245	---	---	---	---	PASS
MYO3A	53904	broad.mit.edu	37	10	26310568	26310568	+	Missense_Mutation	SNP	A	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:26310568A>C	uc001isn.2	+	8	1082	c.722A>C	c.(721-723)AAA>ACA	p.K241T	MYO3A_uc009xko.1_Missense_Mutation_p.K241T|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.K241T|MYO3A_uc001ism.2_Missense_Mutation_p.K241T	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	241	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GCACTCTTCAAAATACCAAGG	0.507													59	133	---	---	---	---	PASS
CCNY	219771	broad.mit.edu	37	10	35854998	35854998	+	Missense_Mutation	SNP	A	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:35854998A>G	uc001iyw.3	+	9	974	c.794A>G	c.(793-795)AAT>AGT	p.N265S	CCNY_uc001iyu.3_Missense_Mutation_p.N211S|CCNY_uc001iyv.3_Missense_Mutation_p.N211S|CCNY_uc001iyx.3_Missense_Mutation_p.N211S|CCNY_uc009xmb.2_Missense_Mutation_p.N240S|CCNY_uc010qet.1_Missense_Mutation_p.N132S	NM_145012	NP_659449	Q8ND76	CCNY_HUMAN	cyclin Y isoform 1	265	Cyclin N-terminal.				cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding				0						TTCAACATCAATGTTCCTTCC	0.483													75	247	---	---	---	---	PASS
BMPR1A	657	broad.mit.edu	37	10	88672053	88672053	+	Missense_Mutation	SNP	A	T	T	rs141608069		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88672053A>T	uc001kdy.2	+	8	1135	c.587A>T	c.(586-588)GAT>GTT	p.D196V		NM_004329	NP_004320	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	196	Cytoplasmic (Potential).				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			lung(3)|large_intestine(1)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	8						TTGGAACAGGATGAAGCATTT	0.358			Mis|N|F			gastrointestinal polyps			Hereditary_Mixed_Polyposis_syndrome_type_2|Juvenile_Polyposis				50	80	---	---	---	---	PASS
GPR123	84435	broad.mit.edu	37	10	134915812	134915812	+	Intron	SNP	A	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134915812A>G	uc001llx.3	+						GPR123_uc001llw.2_Intron	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123							integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		TGAGGACTTCACCTCCTCTCC	0.637													8	8	---	---	---	---	PASS
OR52B2	255725	broad.mit.edu	37	11	6191414	6191414	+	Missense_Mutation	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6191414A>T	uc010qzy.1	-	1	143	c.143T>A	c.(142-144)ATA>AAA	p.I48K		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	48	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AATAACCACTATCAGGATGCT	0.498													54	117	---	---	---	---	PASS
CNGA4	1262	broad.mit.edu	37	11	6265463	6265463	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6265463C>A	uc001mco.2	+	6	1659	c.1552C>A	c.(1552-1554)CTG>ATG	p.L518M	CNGA4_uc010raa.1_3'UTR|CNGA4_uc001mcn.2_3'UTR	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	518	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTGGCTGAGCTGGAGTCCAG	0.597													39	109	---	---	---	---	PASS
OR2AG2	338755	broad.mit.edu	37	11	6789694	6789694	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6789694G>T	uc001meq.1	-	1	495	c.495C>A	c.(493-495)CAC>CAA	p.H165Q		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGAAAGGGAGGTGCATAGTGT	0.512													53	95	---	---	---	---	PASS
TRAF6	7189	broad.mit.edu	37	11	36522776	36522776	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:36522776G>A	uc001mwr.1	-	3	630	c.290C>T	c.(289-291)TCA>TTA	p.S97L	TRAF6_uc001mws.1_Missense_Mutation_p.S97L	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	97	Interaction with TAX1BP1.|RING-type.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				GTACCTTATTGATTTTATGAT	0.423													7	19	---	---	---	---	PASS
PTPRJ	5795	broad.mit.edu	37	11	48164469	48164469	+	Splice_Site	SNP	A	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:48164469A>G	uc001ngp.3	+	12	2799	c.2444_splice	c.e12-2	p.D815_splice		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J						contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						gttttgttttAGATCCCCCTC	0.398													15	32	---	---	---	---	PASS
SPTBN2	6712	broad.mit.edu	37	11	66472844	66472844	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66472844C>A	uc001ojd.2	-	14	1975	c.1903G>T	c.(1903-1905)GCC>TCC	p.A635S		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	635	Spectrin 3.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCCAGCCGGGCCCGCCGCGCC	0.672													16	46	---	---	---	---	PASS
TBC1D10C	374403	broad.mit.edu	37	11	67177085	67177085	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67177085G>T	uc001ola.2	+	10	1230	c.1201G>T	c.(1201-1203)GAG>TAG	p.E401*	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_3'UTR|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	401						intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCCCCCGGAGGAGCCCAGACC	0.726													7	4	---	---	---	---	PASS
PRCP	5547	broad.mit.edu	37	11	82549495	82549495	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82549495C>A	uc001ozs.2	-	8	1321	c.1208G>T	c.(1207-1209)AGG>ATG	p.R403M	PRCP_uc001ozr.2_Missense_Mutation_p.R424M	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	403					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						CCAGGAGGGCCTTGGTCTCAC	0.408													41	114	---	---	---	---	PASS
NOX4	50507	broad.mit.edu	37	11	89223732	89223732	+	Intron	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89223732C>T	uc001pct.2	-						NOX4_uc009yvr.2_Intron|NOX4_uc001pcu.2_Intron|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Intron|NOX4_uc009yvo.2_Intron|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Intron|NOX4_uc009yvq.2_Intron|NOX4_uc009yvs.1_Intron|NOX4_uc001pcy.2_Intron	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CTAAACCAATCAGACATGAGA	0.388													6	158	---	---	---	---	PASS
FAT3	120114	broad.mit.edu	37	11	92534971	92534971	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92534971G>T	uc001pdj.3	+	9	8809	c.8792G>T	c.(8791-8793)GGG>GTG	p.G2931V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2931	Cadherin 27.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGTACCGAGGGAATGTGAAG	0.542										TCGA Ovarian(4;0.039)			44	132	---	---	---	---	PASS
TECTA	7007	broad.mit.edu	37	11	121039502	121039502	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121039502G>A	uc010rzo.1	+	19	5867	c.5867G>A	c.(5866-5868)CGA>CAA	p.R1956Q		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1956	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TTGACGACTCGAGATGTGCTG	0.483													58	160	---	---	---	---	PASS
FLI1	2313	broad.mit.edu	37	11	128680432	128680432	+	Missense_Mutation	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:128680432A>T	uc010sbu.1	+	9	1249	c.908A>T	c.(907-909)GAG>GTG	p.E303V	FLI1_uc010sbt.1_Missense_Mutation_p.E110V|FLI1_uc010sbv.1_Missense_Mutation_p.E270V|FLI1_uc009zci.2_Missense_Mutation_p.E237V	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	303	ETS.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		ATCACCTGGGAGGGGACCAAC	0.617			T	EWSR1	Ewing sarcoma								11	20	---	---	---	---	PASS
BCL2L14	79370	broad.mit.edu	37	12	12247859	12247859	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12247859G>A	uc001rac.2	+	5	1141	c.940G>A	c.(940-942)GGA>AGA	p.G314R	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_Intron|BCL2L14_uc001rad.2_Missense_Mutation_p.G314R|BCL2L14_uc001rae.2_3'UTR	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	314	BH2.				apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		GCAGCACGGTGGATGGGTAAG	0.428													34	77	---	---	---	---	PASS
WBP11	51729	broad.mit.edu	37	12	14952603	14952603	+	Missense_Mutation	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14952603C>G	uc001rci.2	-	4	317	c.156G>C	c.(154-156)CAG>CAC	p.Q52H		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	52					mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						CTCGGATTATCTGTTTTGGAT	0.413													13	64	---	---	---	---	PASS
OVCH1	341350	broad.mit.edu	37	12	29617471	29617471	+	Silent	SNP	A	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:29617471A>G	uc001rix.1	-	18	2094	c.2094T>C	c.(2092-2094)TGT>TGC	p.C698C		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	698	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CGGTCACAGCACAGATCTCCG	0.443													28	53	---	---	---	---	PASS
DNM1L	10059	broad.mit.edu	37	12	32871652	32871652	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:32871652G>A	uc001rld.2	+	7	856	c.695G>A	c.(694-696)GGA>GAA	p.G232E	DNM1L_uc010skf.1_RNA|DNM1L_uc010skg.1_Intron|DNM1L_uc001rle.2_Missense_Mutation_p.G232E|DNM1L_uc001rlf.2_Missense_Mutation_p.G232E|DNM1L_uc010skh.1_Missense_Mutation_p.G298E|DNM1L_uc001rlg.2_Missense_Mutation_p.G298E|DNM1L_uc001rlh.2_Missense_Mutation_p.G285E|DNM1L_uc010ski.1_Intron	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	232	GTPase domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GTATTGATGGGAAGGGTTATT	0.398													78	199	---	---	---	---	PASS
NAV3	89795	broad.mit.edu	37	12	78400573	78400573	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78400573G>T	uc001syp.2	+	8	1428	c.1255G>T	c.(1255-1257)GAA>TAA	p.E419*	NAV3_uc001syo.2_Nonsense_Mutation_p.E419*	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	419						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TGCCTTTTCTGAATCTGGTGA	0.498										HNSCC(70;0.22)			88	142	---	---	---	---	PASS
UTP20	27340	broad.mit.edu	37	12	101750711	101750711	+	Silent	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:101750711C>T	uc001tia.1	+	43	5698	c.5542C>T	c.(5542-5544)CTG>TTG	p.L1848L		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1848	HEAT 2.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TAGTATTTTGCTGAAAGTGTG	0.368													15	60	---	---	---	---	PASS
DTX1	1840	broad.mit.edu	37	12	113531399	113531399	+	Silent	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113531399C>G	uc001tuk.1	+	4	1395	c.1059C>G	c.(1057-1059)GCC>GCG	p.A353A		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	353	Pro-rich.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						TGACGCGGGCCCCCAAGCCCA	0.716													15	16	---	---	---	---	PASS
CHFR	55743	broad.mit.edu	37	12	133419614	133419614	+	Silent	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133419614C>T	uc001ulf.2	-	17	2019	c.1935G>A	c.(1933-1935)GTG>GTA	p.V645V	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Silent_p.V633V|CHFR_uc010tbs.1_Silent_p.V644V|CHFR_uc001uld.2_Silent_p.V604V|CHFR_uc010tbt.1_Silent_p.V553V	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	645	PBZ-type.				cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		GGTGAGCTTTCACCTGAGTGC	0.527													5	29	---	---	---	---	PASS
KLHL1	57626	broad.mit.edu	37	13	70681657	70681657	+	Missense_Mutation	SNP	T	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:70681657T>G	uc001vip.2	-	1	969	c.175A>C	c.(175-177)AGC>CGC	p.S59R	KLHL1_uc010thm.1_Missense_Mutation_p.S59R|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	59	Ser-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTCTCTTGGCTTTTGAGCAGG	0.473													63	49	---	---	---	---	PASS
NDRG2	57447	broad.mit.edu	37	14	21502457	21502457	+	Intron	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21502457T>A	uc010tll.1	-						RNASE13_uc001vzj.2_Intron	NM_201541	NP_963835	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform b						cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TTCCTCCTGCTGGTAGAGTTA	0.562													38	35	---	---	---	---	PASS
RABGGTA	5875	broad.mit.edu	37	14	24737631	24737631	+	Intron	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24737631G>A	uc001wof.2	-						RABGGTA_uc001woe.2_Intron|RABGGTA_uc001wog.2_Intron|RABGGTA_uc001woh.2_Intron|RABGGTA_uc001woi.2_Intron	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha						visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		GGCGGCCTGGGGAAAGAGTAG	0.582													5	93	---	---	---	---	PASS
PRKD1	5587	broad.mit.edu	37	14	30133053	30133053	+	Missense_Mutation	SNP	T	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:30133053T>C	uc001wqh.2	-	4	729	c.548A>G	c.(547-549)AAT>AGT	p.N183S		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	183	Phorbol-ester/DAG-type 1.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CTTATGGTAATTCAGACCACA	0.368													193	123	---	---	---	---	PASS
LRFN5	145581	broad.mit.edu	37	14	42356395	42356395	+	Silent	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:42356395G>A	uc001wvm.2	+	3	1765	c.567G>A	c.(565-567)GGG>GGA	p.G189G	LRFN5_uc010ana.2_Silent_p.G189G	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	189	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTCCTAAGGGGACCTTCTCCC	0.418										HNSCC(30;0.082)			42	38	---	---	---	---	PASS
SIPA1L1	26037	broad.mit.edu	37	14	72138033	72138033	+	Missense_Mutation	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:72138033A>T	uc001xms.2	+	8	2801	c.2453A>T	c.(2452-2454)GAA>GTA	p.E818V	SIPA1L1_uc001xmt.2_Missense_Mutation_p.E818V|SIPA1L1_uc001xmu.2_Missense_Mutation_p.E818V|SIPA1L1_uc001xmv.2_Missense_Mutation_p.E818V|SIPA1L1_uc010ttm.1_Missense_Mutation_p.E293V	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	818	Rap-GAP.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GATCTGGCAGAAAAGAATGTC	0.483													18	76	---	---	---	---	PASS
RPS6KA5	9252	broad.mit.edu	37	14	91366504	91366504	+	Missense_Mutation	SNP	A	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:91366504A>G	uc001xys.2	-	11	1542	c.1327T>C	c.(1327-1329)TGT>CGT	p.C443R	RPS6KA5_uc010twi.1_Missense_Mutation_p.C364R|RPS6KA5_uc001xyt.2_Missense_Mutation_p.C443R	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	443	Protein kinase 2.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		TTATGCACACACTTTCGACAA	0.338													7	198	---	---	---	---	PASS
MARK3	4140	broad.mit.edu	37	14	103941438	103941438	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103941438G>T	uc001ymz.3	+	13	2039	c.1373G>T	c.(1372-1374)AGT>ATT	p.S458I	MARK3_uc001ymx.3_Missense_Mutation_p.S458I|MARK3_uc001ymw.3_Missense_Mutation_p.S458I|MARK3_uc001yna.3_Missense_Mutation_p.S442I|MARK3_uc001ymy.3_Missense_Mutation_p.S379I|MARK3_uc010awp.2_Missense_Mutation_p.S481I|MARK3_uc010tyb.1_Missense_Mutation_p.S253I|MARK3_uc010awq.2_5'UTR	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	458							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			TCAAGTGGCAGTGCTGTTGGA	0.483													56	33	---	---	---	---	PASS
ADAM6	8755	broad.mit.edu	37	14	106967307	106967307	+	RNA	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106967307C>T	uc010tyt.1	-	201		c.9134G>A								Parts of antibodies, mostly variable regions.												0						CCCCAGGCTTCTTCACCTCAG	0.557													9	179	---	---	---	---	PASS
OR4M2	390538	broad.mit.edu	37	15	22369231	22369231	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22369231C>A	uc010tzu.1	+	1	656	c.656C>A	c.(655-657)GCC>GAC	p.A219D	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATGTCCTATGCCTTCCTTCTG	0.478													53	543	---	---	---	---	PASS
SNORD115-20	100033460	broad.mit.edu	37	15	25475996	25475996	+	Intron	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25475996G>A	uc001yzq.1	+						SNORD115-26_uc001yzw.1_Intron|SNORD115-33_uc001zab.1_RNA	NR_003313				Homo sapiens small nucleolar RNA, C/D box 115-15 (SNORD115-15), non-coding RNA.												0						GGTCAATGATGAGAACCGTAT	0.532													34	309	---	---	---	---	PASS
B2M	567	broad.mit.edu	37	15	45007661	45007661	+	Silent	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45007661G>A	uc001zuc.2	+	2	168	c.108G>A	c.(106-108)GAG>GAA	p.E36E	B2M_uc010uek.1_Silent_p.E36E|B2M_uc010bdx.1_Silent_p.E36E	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	36	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		ATCCAGCAGAGAATGGAAAGT	0.408													31	267	---	---	---	---	PASS
GLCE	26035	broad.mit.edu	37	15	69553415	69553415	+	Intron	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69553415C>T	uc002ary.1	+							NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase						heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2						TTTTGTTTCTCTATTTTATAG	0.378													34	108	---	---	---	---	PASS
IGF1R	3480	broad.mit.edu	37	15	99456467	99456467	+	Missense_Mutation	SNP	G	A	A	rs56248469		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:99456467G>A	uc002bul.2	+	8	1834	c.1784G>A	c.(1783-1785)CGT>CAT	p.R595H	IGF1R_uc010urq.1_Missense_Mutation_p.R595H|IGF1R_uc010bon.2_Missense_Mutation_p.R595H|IGF1R_uc010urr.1_Missense_Mutation_p.R45H	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	595	Fibronectin type-III 1.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GACCATATCCGTGGGGCCAAG	0.557													75	214	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	16	33965600	33965600	+	IGR	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:33965600G>A								MIR1826 (8 upstream) : UBE2MP1 (438202 downstream)																							TAGTCCCCGGGGGTGCCTCCG	0.677													12	38	---	---	---	---	PASS
SLC6A2	6530	broad.mit.edu	37	16	55719106	55719106	+	Silent	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55719106G>T	uc002eif.2	+	5	807	c.696G>T	c.(694-696)CTG>CTT	p.L232L	SLC6A2_uc010ccd.2_Silent_p.L232L|SLC6A2_uc002eig.2_Silent_p.L232L|SLC6A2_uc002eih.2_Silent_p.L232L|SLC6A2_uc002eii.2_Silent_p.L127L|SLC6A2_uc002eij.2_5'UTR	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	232	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	ACATCGGCCTGCCCCAGTGGC	0.557													12	42	---	---	---	---	PASS
CDH16	1014	broad.mit.edu	37	16	66946299	66946299	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66946299G>T	uc002eql.2	-	12	1467	c.1394C>A	c.(1393-1395)CCC>CAC	p.P465H	CDH16_uc010cdy.2_Missense_Mutation_p.P465H|CDH16_uc002eqm.2_Missense_Mutation_p.P368H	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	465	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CAGAGTCCCGGGCTCCACATC	0.607													105	53	---	---	---	---	PASS
FTSJD1	55783	broad.mit.edu	37	16	71319357	71319357	+	Missense_Mutation	SNP	T	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71319357T>G	uc010cga.2	-	3	873	c.467A>C	c.(466-468)CAC>CCC	p.H156P	FTSJD1_uc002ezy.3_Missense_Mutation_p.H156P|FTSJD1_uc002ezz.3_Missense_Mutation_p.H156P	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	156						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						TTTTAAGTAGTGGTTGAGACT	0.413													177	112	---	---	---	---	PASS
AP1G1	164	broad.mit.edu	37	16	71795457	71795457	+	Missense_Mutation	SNP	T	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71795457T>C	uc010cgg.2	-	10	1246	c.932A>G	c.(931-933)AAT>AGT	p.N311S	AP1G1_uc002fba.2_Missense_Mutation_p.N314S|AP1G1_uc002fbb.2_Missense_Mutation_p.N334S|AP1G1_uc010vmg.1_RNA	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	311					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				ACCCAGGATATTTATGGCTAG	0.328													67	161	---	---	---	---	PASS
DHX38	9785	broad.mit.edu	37	16	72142486	72142486	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72142486C>A	uc002fcb.2	+	23	3590	c.3235C>A	c.(3235-3237)CAC>AAC	p.H1079N	DHX38_uc010vmp.1_Missense_Mutation_p.H391N	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1079					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				TGCCTATTTCCACCAAGCAGC	0.557													3	54	---	---	---	---	PASS
CNTNAP4	85445	broad.mit.edu	37	16	76501333	76501333	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:76501333G>A	uc002feu.1	+	12	1953	c.1568G>A	c.(1567-1569)GGC>GAC	p.G523D	CNTNAP4_uc002fev.1_Missense_Mutation_p.G387D|CNTNAP4_uc010chb.1_Missense_Mutation_p.G450D|CNTNAP4_uc002fex.1_Missense_Mutation_p.G526D|CNTNAP4_uc002few.2_Missense_Mutation_p.G498D	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	523	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TCTATCAGCGGCAAAGTGGTA	0.443													4	53	---	---	---	---	PASS
CNTNAP4	85445	broad.mit.edu	37	16	76532475	76532475	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:76532475C>A	uc002feu.1	+	17	2634	c.2249C>A	c.(2248-2250)ACT>AAT	p.T750N	CNTNAP4_uc002fev.1_Missense_Mutation_p.T614N|CNTNAP4_uc010chb.1_Missense_Mutation_p.T677N|CNTNAP4_uc002fex.1_Missense_Mutation_p.T753N	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	750	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						ACCAATGACACTGGATTGCTT	0.373													28	41	---	---	---	---	PASS
ZNF276	92822	broad.mit.edu	37	16	89789138	89789138	+	Silent	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89789138C>G	uc002fos.3	+	2	502	c.405C>G	c.(403-405)GTC>GTG	p.V135V	C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Silent_p.V60V|ZNF276_uc002foq.3_Silent_p.V60V|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	135	ZAD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCCGTTTGTCTGCAAGAGCT	0.642													44	115	---	---	---	---	PASS
FANCA	2175	broad.mit.edu	37	16	89838110	89838110	+	Silent	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89838110C>A	uc002fou.1	-	23	2169	c.2127G>T	c.(2125-2127)CCG>CCT	p.P709P	FANCA_uc010vpn.1_Silent_p.P709P	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	709					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GCTCCAGTCTCGGCGTGTTGA	0.527			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				86	156	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7577580	7577580	+	Missense_Mutation	SNP	T	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7577580T>C	uc002gim.2	-	7	895	c.701A>G	c.(700-702)TAC>TGC	p.Y234C	TP53_uc002gig.1_Missense_Mutation_p.Y234C|TP53_uc002gih.2_Missense_Mutation_p.Y234C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y102C|TP53_uc010cng.1_Missense_Mutation_p.Y102C|TP53_uc002gii.1_Missense_Mutation_p.Y102C|TP53_uc010cnh.1_Missense_Mutation_p.Y234C|TP53_uc010cni.1_Missense_Mutation_p.Y234C|TP53_uc002gij.2_Missense_Mutation_p.Y234C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y141C|TP53_uc002gio.2_Missense_Mutation_p.Y102C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	234	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> F (in a sporadic cancer; somatic mutation).|Y -> K (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|Y -> N (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> Q (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y234C(70)|p.Y234H(13)|p.Y234N(11)|p.0?(7)|p.Y234S(6)|p.Y234*(4)|p.Y234D(3)|p.Y234del(3)|p.Y234fs*2(1)|p.V225fs*23(1)|p.Y234fs*6(1)|p.Y234fs*5(1)|p.Y234fs*4(1)|p.Y234R(1)|p.Y234Y(1)|p.H233_C242del10(1)|p.D228fs*12(1)|p.Y234F(1)|p.I232_Y236delIHYNY(1)|p.Y141S(1)|p.T230_Y234delTTIHY(1)|p.H233fs*6(1)|p.Y234_N235insX(1)|p.I232fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGTAGTTGTAGTGGATGGT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			34	37	---	---	---	---	PASS
FLOT2	2319	broad.mit.edu	37	17	27208211	27208211	+	Missense_Mutation	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27208211T>A	uc002hdc.2	-	9	1220	c.1097A>T	c.(1096-1098)CAG>CTG	p.Q366L		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	366					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			AAGCCTCACCTGGGGCAGGGC	0.587													9	29	---	---	---	---	PASS
SUZ12	23512	broad.mit.edu	37	17	30320963	30320963	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30320963G>A	uc002hgs.2	+	12	1595	c.1373G>A	c.(1372-1374)CGC>CAC	p.R458H	SUZ12_uc002hgt.2_Missense_Mutation_p.R435H	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	458	C2H2-type.				negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				CTGAACTGCCGCAAACTTTAT	0.313			T	JAZF1	endometrial stromal tumours								5	199	---	---	---	---	PASS
PPP1R1B	84152	broad.mit.edu	37	17	37792130	37792130	+	3'UTR	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37792130G>A	uc002hrz.2	+	7					PPP1R1B_uc002hsa.2_3'UTR|PPP1R1B_uc010cvx.2_3'UTR|PPP1R1B_uc002hsb.2_3'UTR|PPP1R1B_uc002hsc.2_3'UTR|STARD3_uc010weg.1_5'Flank|STARD3_uc002hsd.2_5'Flank|STARD3_uc010weh.1_5'Flank|STARD3_uc002hse.2_5'Flank|STARD3_uc010wei.1_5'Flank	NM_032192	NP_115568	Q9UD71	PPR1B_HUMAN	protein phosphatase 1, regulatory (inhibitor)						signal transduction	cytosol	protein kinase inhibitor activity|protein phosphatase inhibitor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CACCCAGCCTGCATCTCCCAG	0.632													754	27	---	---	---	---	PASS
SAMD14	201191	broad.mit.edu	37	17	48193457	48193457	+	Intron	SNP	T	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48193457T>C	uc002iqg.2	-						SAMD14_uc002iqd.2_Intron|SAMD14_uc002iqe.2_Intron|SAMD14_uc002iqf.2_Intron	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14												0						GCTGTCATCTTTCCAGGGAGA	0.493													22	54	---	---	---	---	PASS
PSMC5	5705	broad.mit.edu	37	17	61907223	61907223	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61907223C>T	uc002jcb.2	+	4	219	c.178C>T	c.(178-180)CGG>TGG	p.R60W	FTSJ3_uc002jbz.2_5'Flank|FTSJ3_uc002jca.2_5'Flank|PSMC5_uc010ddy.2_Missense_Mutation_p.R37W|PSMC5_uc010ddz.2_5'UTR|PSMC5_uc002jcc.2_Missense_Mutation_p.R52W|PSMC5_uc002jcd.2_Missense_Mutation_p.R52W	NM_002805	NP_002796	P62195	PRS8_HUMAN	proteasome 26S ATPase subunit 5	60			R -> Q (in a colorectal cancer sample; somatic mutation).		anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding	p.R60Q(1)		large_intestine(1)	1						TCGCCTATTGCGGGAGGAGCT	0.522													37	86	---	---	---	---	PASS
ABCA10	10349	broad.mit.edu	37	17	67217927	67217927	+	Intron	SNP	A	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67217927A>T	uc010dfa.1	-						ABCA10_uc010wqt.1_Intron|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10						transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAAGTTAGGCACTTACTTCTA	0.224													26	57	---	---	---	---	PASS
PTPRM	5797	broad.mit.edu	37	18	8113488	8113488	+	Missense_Mutation	SNP	T	C	C			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:8113488T>C	uc002knn.3	+	12	2364	c.1861T>C	c.(1861-1863)TAT>CAT	p.Y621H	PTPRM_uc010dkv.2_Missense_Mutation_p.Y621H|PTPRM_uc010wzl.1_Missense_Mutation_p.Y408H	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	621	Fibronectin type-III 4.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TTCTAGTGTCTATCAAATAGT	0.393													29	142	---	---	---	---	PASS
NOL4	8715	broad.mit.edu	37	18	31599521	31599521	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:31599521G>A	uc010dmi.2	-	6	1046	c.817C>T	c.(817-819)CAC>TAC	p.H273Y	NOL4_uc010xbs.1_5'UTR|NOL4_uc002kxr.3_Missense_Mutation_p.H109Y|NOL4_uc010xbt.1_Missense_Mutation_p.H199Y|NOL4_uc010dmh.2_Missense_Mutation_p.H199Y|NOL4_uc010xbu.1_Missense_Mutation_p.H273Y|NOL4_uc002kxt.3_Missense_Mutation_p.H273Y|NOL4_uc010xbv.1_Missense_Mutation_p.H22Y|NOL4_uc010xbw.1_Missense_Mutation_p.H159Y	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	273						nucleolus	RNA binding			ovary(3)	3						ATTGAACTGTGCCCCAGAGTC	0.438													39	106	---	---	---	---	PASS
SETBP1	26040	broad.mit.edu	37	18	42530539	42530539	+	Missense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:42530539G>T	uc010dni.2	+	4	1530	c.1234G>T	c.(1234-1236)GAT>TAT	p.D412Y		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	412						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		ACCCTCTCTGGATCCAACCAA	0.483									Schinzel-Giedion_syndrome				30	74	---	---	---	---	PASS
ST8SIA5	29906	broad.mit.edu	37	18	44284606	44284606	+	Silent	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44284606C>A	uc002lcj.1	-	2	721	c.153G>T	c.(151-153)GGG>GGT	p.G51G	ST8SIA5_uc002lci.1_5'UTR|ST8SIA5_uc010xcy.1_Silent_p.G87G|ST8SIA5_uc010xcz.1_Intron|ST8SIA5_uc010dno.1_Silent_p.G87G	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	51	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						ATTCAAAAGGCCCCTCATAAA	0.512													79	177	---	---	---	---	PASS
CDH20	28316	broad.mit.edu	37	18	59221438	59221438	+	Missense_Mutation	SNP	T	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:59221438T>A	uc010dps.1	+	11	1928	c.1916T>A	c.(1915-1917)ATT>AAT	p.I639N	CDH20_uc002lif.2_Missense_Mutation_p.I633N	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	639	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				GTGTTGCTCATTTTGTCCATG	0.542													55	85	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9017026	9017026	+	Intron	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9017026G>T	uc002mkp.2	-							NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTGCATAGAGAAGGAGGGAG	0.517													19	51	---	---	---	---	PASS
ZNF136	7695	broad.mit.edu	37	19	12298583	12298583	+	Silent	SNP	C	A	A	rs149571290		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12298583C>A	uc002mti.2	+	4	1490	c.1390C>A	c.(1390-1392)CGA>AGA	p.R464R	ZNF136_uc010xmh.1_Silent_p.R398R	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	464	C2H2-type 12.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						CAACTCCTTTCGAACACATGA	0.393													3	87	---	---	---	---	PASS
PLVAP	83483	broad.mit.edu	37	19	17476990	17476990	+	Silent	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17476990G>A	uc002ngk.1	-	2	434	c.384C>T	c.(382-384)AAC>AAT	p.N128N		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	128	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						ACCTCTGATTGTTCGTGTAGA	0.537													34	213	---	---	---	---	PASS
LRRC25	126364	broad.mit.edu	37	19	18507431	18507431	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18507431C>T	uc002niw.2	-	1	985	c.343G>A	c.(343-345)GAC>AAC	p.D115N	LRRC25_uc002nix.2_Missense_Mutation_p.D115N	NM_145256	NP_660299	Q8N386	LRC25_HUMAN	leucine rich repeat containing 25 precursor	115	Extracellular (Potential).					integral to membrane					0						CAGTTGCAGTCGGCCTGCAGG	0.632													28	49	---	---	---	---	PASS
ZNF665	79788	broad.mit.edu	37	19	53668050	53668050	+	Missense_Mutation	SNP	T	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53668050T>G	uc010eqm.1	-	4	1793	c.1693A>C	c.(1693-1695)ACT>CCT	p.T565P		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	500					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TTCTCACCAGTGTGAATTCTC	0.393													41	148	---	---	---	---	PASS
LILRB3	11025	broad.mit.edu	37	19	54745537	54745537	+	Splice_Site	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54745537C>T	uc002qej.1	-	4		c.696_splice	c.e4+1		LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Silent_p.R191R|LILRA6_uc002qek.1_Silent_p.R191R|LILRB3_uc010erh.1_Intron|LILRA6_uc002qel.1_Silent_p.R191R|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_Splice_Site|LILRB3_uc002qeo.1_Silent_p.R191R|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Silent_p.R191R|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Silent_p.R191R|LILRA6_uc010yep.1_Silent_p.R191R|LILRA6_uc010yeq.1_Silent_p.R191R|LILRA6_uc002qet.3_Splice_Site|LILRA6_uc002qeu.1_Silent_p.R191R|LILRA6_uc002qev.1_Silent_p.R52R			O75022	LIRB3_HUMAN	Synthetic construct DNA, clone: pF1KB7252, Homo sapiens LILRA6 gene for leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6, without stop codon, in Flexi system.						cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGAACCTCCACCTGTGGCTGG	0.632													39	36	---	---	---	---	PASS
ASXL1	171023	broad.mit.edu	37	20	31024614	31024614	+	Missense_Mutation	SNP	G	A	A	rs147456014	byFrequency	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31024614G>A	uc002wxs.2	+	12	4525	c.4099G>A	c.(4099-4101)GTC>ATC	p.V1367I	ASXL1_uc010geb.2_Missense_Mutation_p.V1258I	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1367					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						TGTTGGCAGCGTCAAGAATGA	0.537			F|N|Mis		MDS|CMML								45	149	---	---	---	---	PASS
C20orf177	63939	broad.mit.edu	37	20	58519998	58519998	+	Missense_Mutation	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58519998G>A	uc002yba.2	+	5	1415	c.1000G>A	c.(1000-1002)GAC>AAC	p.D334N	C20orf177_uc010zzx.1_Missense_Mutation_p.D177N|C20orf177_uc002ybc.2_Missense_Mutation_p.D334N	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	334										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)			TGTGATTCTGGACTCAGCAGA	0.527													30	58	---	---	---	---	PASS
IFNGR2	3460	broad.mit.edu	37	21	34793789	34793789	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34793789C>T	uc002yrp.3	+	3	857	c.209C>T	c.(208-210)ACC>ATC	p.T70I	IFNGR2_uc002yrq.3_Missense_Mutation_p.T89I|IFNGR2_uc010gma.2_5'UTR|IFNGR2_uc002yrr.3_5'UTR	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	70	Extracellular (Potential).|Fibronectin type-III 1.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	CTTCCCAGCACCGACAGTAAA	0.448													37	70	---	---	---	---	PASS
MORC3	23515	broad.mit.edu	37	21	37747568	37747568	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37747568C>A	uc002yvi.2	+	17	2870	c.2794C>A	c.(2794-2796)CAA>AAA	p.Q932K		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	932					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						AGTTGTTGAACAAATGAGTGA	0.318													46	62	---	---	---	---	PASS
CECR2	27443	broad.mit.edu	37	22	18022266	18022266	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18022266C>T	uc010gqw.1	+	15	2494	c.2368C>T	c.(2368-2370)CGA>TGA	p.R790*	CECR2_uc010gqv.1_Nonsense_Mutation_p.R649*|CECR2_uc002zml.2_Nonsense_Mutation_p.R649*	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	832					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		GATGGATTCCCGAGTCATGAG	0.602													22	101	---	---	---	---	PASS
WDR45	11152	broad.mit.edu	37	X	48932917	48932917	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48932917C>T	uc004dmk.1	-	10	1023	c.851G>A	c.(850-852)GGG>GAG	p.G284E	PRAF2_uc004dmh.2_5'Flank|PRAF2_uc004dmi.2_5'Flank|PRAF2_uc011mmt.1_Intron|WDR45_uc004dmj.1_Missense_Mutation_p.G245E|WDR45_uc004dml.1_Missense_Mutation_p.G285E|WDR45_uc004dmm.1_Missense_Mutation_p.G249E|WDR45_uc010nim.1_Intron|WDR45_uc004dmn.1_Missense_Mutation_p.G175E|WDR45_uc004dmo.1_Missense_Mutation_p.G307E|WDR45_uc004dmp.1_Missense_Mutation_p.G285E	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	284					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1						AATCATAGGCCCCACCTTGCC	0.622													14	3	---	---	---	---	PASS
GPRASP1	9737	broad.mit.edu	37	X	101911509	101911509	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:101911509G>T	uc004ejj.3	+	5	3469	c.2668G>T	c.(2668-2670)GGA>TGA	p.G890*	GPRASP1_uc004eji.3_Nonsense_Mutation_p.G890*|GPRASP1_uc010nod.2_Nonsense_Mutation_p.G890*	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	890	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						TATACAGGCTGGATCTCAGGC	0.507													83	51	---	---	---	---	PASS
MAGEC1	9947	broad.mit.edu	37	X	140995582	140995582	+	Missense_Mutation	SNP	C	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140995582C>T	uc004fbt.2	+	4	2678	c.2392C>T	c.(2392-2394)CCT>TCT	p.P798S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	798							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCATGAGAGTCCTCAGAGTCC	0.567										HNSCC(15;0.026)			171	121	---	---	---	---	PASS
MAGEC1	9947	broad.mit.edu	37	X	140995591	140995591	+	Missense_Mutation	SNP	C	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140995591C>A	uc004fbt.2	+	4	2687	c.2401C>A	c.(2401-2403)CCT>ACT	p.P801T	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	801							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGTCCTCCTGAGGG	0.562										HNSCC(15;0.026)			168	114	---	---	---	---	PASS
PASD1	139135	broad.mit.edu	37	X	150840052	150840052	+	Missense_Mutation	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150840052C>G	uc004fev.3	+	13	1570	c.1238C>G	c.(1237-1239)CCA>CGA	p.P413R		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	413						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGAAGCAGCCAAACACATTA	0.502													10	220	---	---	---	---	PASS
CNGA2	1260	broad.mit.edu	37	X	150911761	150911761	+	Silent	SNP	G	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150911761G>T	uc004fey.1	+	7	1010	c.786G>T	c.(784-786)CGG>CGT	p.R262R		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	262	Extracellular (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTTGACCGGACAGAGACAC	0.517													112	54	---	---	---	---	PASS
GABRA3	2556	broad.mit.edu	37	X	151562967	151562967	+	Intron	SNP	C	G	G			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151562967C>G	uc010ntk.1	-						MIR105-1_hsa-mir-105-1|MI0000111_5'Flank|uc004ffo.2_5'Flank|MIR767_hsa-mir-767|MI0003763_5'Flank|MIR105-2_hsa-mir-105-2|MI0000112_5'Flank|uc011myf.1_5'Flank	NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3						gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GATGCACACACAGAAGATCTG	0.448													20	21	---	---	---	---	PASS
L1CAM	3897	broad.mit.edu	37	X	153136336	153136336	+	Silent	SNP	G	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153136336G>A	uc004fjb.2	-	6	711	c.603C>T	c.(601-603)TCC>TCT	p.S201S	L1CAM_uc004fjc.2_Silent_p.S201S|L1CAM_uc010nuo.2_Silent_p.S196S|L1CAM_uc004fjd.1_Silent_p.S15S|L1CAM_uc004fje.1_Silent_p.S196S	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	201	Extracellular (Potential).|Ig-like C2-type 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTGGTTGTCGGAGGTGAGCA	0.587													69	26	---	---	---	---	PASS
NBPF9	400818	broad.mit.edu	37	1	145055321	145055322	+	Intron	DEL	GT	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145055321_145055322delGT	uc010oye.1	+						NBPF10_uc009wir.2_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001emh.2_Intron			Q3BBV1	NBPFK_HUMAN	RecName: Full=Neuroblastoma breakpoint family member 8;							cytoplasm					0						TCTTGAGGAAgtgtgtgtgtgt	0.351													4	2	---	---	---	---	
MAEL	84944	broad.mit.edu	37	1	166973742	166973742	+	Intron	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:166973742delA	uc001gdy.1	+						MAEL_uc001gdz.1_Intron|MAEL_uc009wvf.1_Intron	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						TGAAGACTGCAAAAGCTAAAC	0.313													2	5	---	---	---	---	
Unknown	0	broad.mit.edu	37	1	202790257	202790258	+	Intron	DEL	AC	-	-	rs113450852		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202790257_202790258delAC	uc001gyh.2	+											Homo sapiens hypothetical protein LOC641515, mRNA (cDNA clone MGC:33633 IMAGE:4827085), complete cds.																		agcGGTGTATacacacacacac	0.124													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	1	207273434	207273439	+	IGR	DEL	TGTGTA	-	-	rs35665980		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207273434_207273439delTGTGTA								C4BPB (99 upstream) : C4BPA (4072 downstream)																							tgtgtgtgtgtgtgtatgtgtgtgtg	0.257													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	2	313478	313483	+	IGR	DEL	GTGTGT	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:313478_313483delGTGTGT								FAM150B (25170 upstream) : TMEM18 (354492 downstream)																							TAGGGAAGGGgtgtgtgtgtgtgtgt	0.286													4	4	---	---	---	---	
ROCK2	9475	broad.mit.edu	37	2	11340846	11340846	+	Intron	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11340846delA	uc002rbd.1	-							NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein						axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		GTTTAAAAAGAAAAAAAAAAA	0.343													4	2	---	---	---	---	
CENPO	79172	broad.mit.edu	37	2	25038107	25038108	+	Intron	DEL	AA	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25038107_25038108delAA	uc002rfo.1	+						CENPO_uc002rfn.2_Intron|CENPO_uc002rfp.1_Intron|CENPO_uc002rfq.1_Intron	NM_024322	NP_077298	Q9BU64	CENPO_HUMAN	centromere protein O						cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					accctatctcaaaaaaaaaaaa	0.134													5	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	2	89399858	89399859	+	Intron	INS	-	AA	AA			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89399858_89399859insAA	uc010ytr.1	-						uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		GATTCCTGCACAGTCTGACCAG	0.569													6	4	---	---	---	---	
DPP10	57628	broad.mit.edu	37	2	115376959	115376960	+	Intron	DEL	TG	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:115376959_115376960delTG	uc002tla.1	+						DPP10_uc002tlb.1_Intron	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						tatatacatatgtgtgtgtgtg	0.243													3	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	2	133018714	133018715	+	IGR	DEL	GT	-	-	rs141065944		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:133018714_133018715delGT								NCRNA00164 (3172 upstream) : GPR39 (155432 downstream)																							GGGCGGGGTGGTGGGGGGTGCC	0.530													6	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	3	26990550	26990557	+	IGR	DEL	AGGAAGGG	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:26990550_26990557delAGGAAGGG								LRRC3B (238287 upstream) : NEK10 (161838 downstream)																							gggaggaggaaggaagggaggaagggag	0.062													6	7	---	---	---	---	
GBE1	2632	broad.mit.edu	37	3	81541861	81541868	+	Intron	DEL	TTCCTTCC	-	-	rs67220037		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:81541861_81541868delTTCCTTCC	uc003dqg.2	-							NM_000158	NP_000149	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1						glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(3)	3		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		ctttcttcctttccttccttccttcctt	0.000									Glycogen_Storage_Disease_type_IV				3	3	---	---	---	---	
RAB7A	7879	broad.mit.edu	37	3	128532447	128532450	+	3'UTR	DEL	CACA	-	-	rs71790935		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128532447_128532450delCACA	uc003eks.1	+	6					RAB7A_uc010hsv.1_3'UTR|RAB7A_uc003ekt.2_Frame_Shift_Del_p.H194fs	NM_004637	NP_004628	P51149	RAB7A_HUMAN	RAB7, member RAS oncogene family						endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding				0				GBM - Glioblastoma multiforme(114;0.231)		cacacacacgcacacacacacaca	0.431													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	3	194712070	194712081	+	IGR	DEL	TTCCTCCTCCTA	-	-	rs149758351	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194712070_194712081delTTCCTCCTCCTA								FAM43A (302306 upstream) : C3orf21 (76934 downstream)																							cctcctcctcttcctcctcctactcctcttcc	0.085													5	5	---	---	---	---	
ALB	213	broad.mit.edu	37	4	74270303	74270303	+	Intron	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:74270303delA	uc003hgs.3	+						ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_Intron|ALB_uc003hgt.3_Intron|ALB_uc010iii.2_Intron|ALB_uc003hgu.3_Intron|ALB_uc003hgv.3_Intron|ALB_uc011cbf.1_5'Flank	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein						bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CATCCTAGGTAAAAAAAAAAA	0.279													4	2	---	---	---	---	
ZDHHC11	79844	broad.mit.edu	37	5	845557	845557	+	Intron	DEL	C	-	-	rs11347292		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:845557delC	uc011cma.1	-						ZDHHC11_uc003jbj.2_Intron|ZDHHC11_uc010itd.1_5'Flank|ZDHHC11_uc003jbk.2_5'Flank	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11							integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			CTCCCCGCAGCCACCCAGGGA	0.607													3	3	---	---	---	---	
ADAMTS16	170690	broad.mit.edu	37	5	5232302	5232302	+	Intron	DEL	A	-	-	rs10713189		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5232302delA	uc003jdl.2	+						ADAMTS16_uc003jdk.1_Intron|ADAMTS16_uc010itk.1_5'Flank	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TTGGGTAAGGAAAAAAAAAAC	0.363													5	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	5	6571881	6571884	+	IGR	DEL	GAAG	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:6571881_6571884delGAAG								UBE2QL1 (79176 upstream) : LOC255167 (10403 downstream)																							agggaggagagaaggaaggaagga	0.000													9	5	---	---	---	---	
Unknown	0	broad.mit.edu	37	5	159674905	159674905	+	IGR	DEL	A	-	-	rs10568222		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:159674905delA								FABP6 (9176 upstream) : CCNJL (3766 downstream)																							actctggctcaaaaaaaaaaa	0.229													4	3	---	---	---	---	
SNAP91	9892	broad.mit.edu	37	6	84417256	84417257	+	Intron	DEL	GT	-	-	rs111588453		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84417256_84417257delGT	uc011dze.1	-						SNAP91_uc003pkb.2_Intron|SNAP91_uc003pkc.2_Intron|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Intron|SNAP91_uc011dzf.1_Intron	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog						clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		atacatatgcgtgtgtgtgtgt	0.238													4	2	---	---	---	---	
C6orf165	154313	broad.mit.edu	37	6	88125702	88125702	+	Intron	DEL	A	-	-	rs34892535		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88125702delA	uc003plv.2	+						C6orf165_uc003plw.2_Intron|C6orf165_uc010kbv.1_Intron|C6orf165_uc003plu.1_Intron	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1											central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TTTTTATCTGAAAAAAAAAAA	0.279													4	2	---	---	---	---	
MLLT4	4301	broad.mit.edu	37	6	168319289	168319290	+	Intron	DEL	TG	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:168319289_168319290delTG	uc003qwd.2	+						MLLT4_uc003qwb.1_Intron|MLLT4_uc003qwc.1_Intron|MLLT4_uc003qwg.1_Intron	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia						adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TGCGTCTGTCTGTGTGTGTGTG	0.500			T	MLL	AL								4	3	---	---	---	---	
C7orf10	79783	broad.mit.edu	37	7	40703085	40703086	+	Intron	DEL	TG	-	-	rs72370211		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:40703085_40703086delTG	uc003thn.1	+						C7orf10_uc003thm.1_Intron|C7orf10_uc003tho.1_Intron	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13								transferase activity			ovary(2)	2						Ttgtggtgtatgtgtgtgtgtg	0.213													4	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	7	52735164	52735165	+	IGR	INS	-	TA	TA	rs149137028	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:52735164_52735165insTA								None (None upstream) : POM121L12 (368184 downstream)																							gtgtgtgtgtgtgtgtgtacca	0.000													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	7	55659699	55659699	+	IGR	DEL	C	-	-	rs140374894		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:55659699delC								VOPP1 (19499 upstream) : LOC442308 (53613 downstream)																							CTCAGCTGCACCCCCCCTCTT	0.587													3	6	---	---	---	---	
PPP3CC	5533	broad.mit.edu	37	8	22379653	22379654	+	Intron	DEL	CA	-	-	rs35520234		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22379653_22379654delCA	uc003xbs.2	+						PPP3CC_uc003xbr.1_Intron|PPP3CC_uc011kzi.1_Intron|PPP3CC_uc003xbt.2_Intron|PPP3CC_uc011kzj.1_5'Flank	NM_005605	NP_005596	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma						activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		cacacacacgcacacacacaca	0.218													4	2	---	---	---	---	
LOXL2	4017	broad.mit.edu	37	8	23225326	23225327	+	Intron	INS	-	CT	CT	rs139416671	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23225326_23225327insCT	uc003xdh.1	-							NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor						aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TCAAGCCCCCCGACCCCGCCTT	0.386													5	3	---	---	---	---	
STC1	6781	broad.mit.edu	37	8	23709570	23709571	+	Intron	DEL	TG	-	-	rs113294965		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23709570_23709571delTG	uc003xdw.1	-							NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor						cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TGAGTGCCTCtgtgtgtgtgtg	0.431													8	5	---	---	---	---	
CLU	1191	broad.mit.edu	37	8	27467946	27467946	+	Intron	DEL	C	-	-	rs9331894	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27467946delC	uc003xfw.1	-						CLU_uc010lux.1_Intron|CLU_uc003xfx.1_Intron|CLU_uc003xfy.1_Intron|CLU_uc003xfz.1_Intron	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2						chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TGCCCTCTGACCTCATCACCC	0.562													113	52	---	---	---	---	
TRIM55	84675	broad.mit.edu	37	8	67039907	67039908	+	Intron	INS	-	A	A	rs72514875		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67039907_67039908insA	uc003xvv.2	+						TRIM55_uc003xvu.2_Intron|TRIM55_uc003xvw.2_Intron|TRIM55_uc003xvx.2_Intron	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1							cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			actaaaaatacaaaaaaaaaaa	0.000													4	2	---	---	---	---	
CSPP1	79848	broad.mit.edu	37	8	68049569	68049569	+	Intron	DEL	A	-	-	rs34987713		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68049569delA	uc003xxi.2	+						CSPP1_uc003xxg.1_Intron|CSPP1_uc003xxh.1_Intron|CSPP1_uc003xxj.2_Intron|CSPP1_uc003xxk.2_Intron	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1							centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TACACTGGGGAAAAAAAAAAA	0.224													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	9	65979067	65979067	+	IGR	DEL	T	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:65979067delT								FAM74A4 (484681 upstream) : LOC442421 (517403 downstream)																							TGTACCCATCttttttttttt	0.209													4	2	---	---	---	---	
WNK2	65268	broad.mit.edu	37	9	96061682	96061682	+	Intron	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96061682delA	uc004ati.1	+						WNK2_uc011lud.1_Intron|WNK2_uc004atj.2_Intron|WNK2_uc004atk.2_Intron	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2						intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TAAAAAGGATAAAAAAAAAAA	0.493													4	4	---	---	---	---	
ABCA2	20	broad.mit.edu	37	9	139917547	139917548	+	Intron	DEL	GA	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139917547_139917548delGA	uc011mem.1	-						ABCA2_uc011mel.1_Intron|ABCA2_uc004ckl.1_Intron|ABCA2_uc004ckm.1_Intron|ABCA2_uc004cko.1_5'Flank|ABCA2_uc010nca.2_5'UTR	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2						cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ggtgaaaggggagagagagaga	0.248													9	4	---	---	---	---	
Unknown	0	broad.mit.edu	37	10	13199671	13199672	+	IGR	INS	-	G	G	rs113702003		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13199671_13199672insG								OPTN (19395 upstream) : MCM10 (3909 downstream)																							tttttttttttttttttttttg	0.183													12	7	---	---	---	---	
Unknown	0	broad.mit.edu	37	10	109829934	109829935	+	IGR	INS	-	CCTTCCTT	CCTTCCTT			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:109829934_109829935insCCTTCCTT								SORCS1 (905642 upstream) : None (None downstream)																							tcctctcctGCccttccttcct	0.183													6	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	11	39242389	39242409	+	IGR	DEL	AAAGGAAGGAAGGAAGGAAAA	-	-	rs72044273	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:39242389_39242409delAAAGGAAGGAAGGAAGGAAAA								None (None upstream) : LRRC4C (893344 downstream)																							aggaaggaagaaaggaaggaaggaaggaaaagaaaagaaaa	0.059													4	4	---	---	---	---	
FNBP4	23360	broad.mit.edu	37	11	47788664	47788669	+	In_Frame_Del	DEL	GGTGGT	-	-	rs59413596		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47788664_47788669delGGTGGT	uc009ylv.2	-	1	325_330	c.172_177delACCACC	c.(172-177)ACCACCdel	p.TT58del	FNBP4_uc001ngj.2_5'UTR|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	58_59										ovary(1)	1						CAGTCACCGCGGTGGTGGTGGTCGTC	0.748													5	3	---	---	---	---	
KNTC1	9735	broad.mit.edu	37	12	123089080	123089081	+	Intron	INS	-	TTTA	TTTA			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123089080_123089081insTTTA	uc001ucv.2	+						KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GCCTGTAAATCtttatttattt	0.248													6	3	---	---	---	---	
CHFR	55743	broad.mit.edu	37	12	133447118	133447118	+	Intron	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133447118delA	uc001ulf.2	-						CHFR_uc001ulc.1_Intron|CHFR_uc001ule.2_Intron|CHFR_uc010tbs.1_Intron|CHFR_uc001uld.2_Intron|CHFR_uc010tbt.1_Intron	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains						cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		actccgtctcaaaaaaaaaaa	0.000													6	3	---	---	---	---	
KIAA0564	23078	broad.mit.edu	37	13	42465337	42465338	+	Intron	INS	-	A	A	rs11422492		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42465337_42465338insA	uc001uyj.2	-						KIAA0564_uc001uyk.2_Intron	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a							extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		ttagactgaccaaaaaaaaaaa	0.144													4	2	---	---	---	---	
MIPOL1	145282	broad.mit.edu	37	14	37891952	37891952	+	Intron	DEL	T	-	-	rs112737768		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:37891952delT	uc001wuc.2	+						MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Intron|MIPOL1_uc001wud.2_Intron|MIPOL1_uc010ams.2_Intron|MIPOL1_uc001wue.2_Intron|MIPOL1_uc010amt.2_Intron	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1											ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		CATTCATAGGTTTTTTTTTTT	0.249													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	14	45759125	45759126	+	IGR	INS	-	T	T	rs147664699	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45759125_45759126insT								C14orf106 (36520 upstream) : None (None downstream)																							ACATTTAAGAATTTTTTTTTAG	0.312													3	3	---	---	---	---	
LYSMD2	256586	broad.mit.edu	37	15	52020593	52020594	+	Intron	INS	-	AC	AC	rs113776739		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52020593_52020594insAC	uc002abi.2	-						LYSMD2_uc002abj.2_Intron	NM_153374	NP_699205	Q8IV50	LYSM2_HUMAN	LysM, putative peptidoglycan-binding, domain						cell wall macromolecule catabolic process						0				all cancers(107;0.00258)		tccagGAGAAAacacacacaca	0.025													4	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	15	90824949	90824950	+	IGR	INS	-	A	A	rs71858955		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90824949_90824950insA								TTLL13 (9506 upstream) : GABARAPL3 (64815 downstream)																							gactctgcctcaaaaaaaaaaa	0.149													4	3	---	---	---	---	
NAT15	79903	broad.mit.edu	37	16	3529763	3529764	+	Intron	INS	-	TG	TG	rs151028988	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3529763_3529764insTG	uc002cvh.3	+						NAT15_uc010uxb.1_Intron|NAT15_uc010btk.1_Intron|NAT15_uc010btl.2_Intron|NAT15_uc010btm.2_Intron|NAT15_uc010uxc.1_Intron|NAT15_uc010uxd.1_Intron|NAT15_uc010uxe.1_Intron|NAT15_uc002cvg.1_Intron	NM_001083601	NP_001077070	Q9H7X0	NAT15_HUMAN	N-acetyltransferase 15								N-acetyltransferase activity				0						TGGTGCTTTTCTGTGTGTGTGT	0.426													4	3	---	---	---	---	
PARN	5073	broad.mit.edu	37	16	14700252	14700252	+	Intron	DEL	G	-	-	rs62037478		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14700252delG	uc010uzd.1	-						PARN_uc010uzc.1_Intron|PARN_uc010uze.1_Intron|PARN_uc010uzf.1_Intron|PARN_uc010uzg.1_Intron	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation						female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						aagaccctgagggaaaaaaaa	0.139													4	2	---	---	---	---	
CNTROB	116840	broad.mit.edu	37	17	7837445	7837446	+	Intron	INS	-	T	T			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7837445_7837446insT	uc002gjq.2	+						TRAPPC1_uc002gjo.1_5'Flank|CNTROB_uc002gjp.2_Intron|CNTROB_uc002gjr.2_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein						centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				TTCCATGTGGCTTTTTTCCAGG	0.446													61	36	---	---	---	---	
EFCAB5	374786	broad.mit.edu	37	17	28320515	28320516	+	Intron	INS	-	A	A	rs78216599		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28320515_28320516insA	uc002het.2	+						EFCAB5_uc010wbi.1_Intron|EFCAB5_uc010wbj.1_Intron|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_Intron|EFCAB5_uc010cse.2_Intron|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a								calcium ion binding			ovary(1)|skin(1)	2						TGAGCATTACCAAAAAAAAAAA	0.347													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	17	29369492	29369493	+	IGR	DEL	CA	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29369492_29369493delCA								RNF135 (42567 upstream) : NF1 (52502 downstream)																							cacaggcaagcacacacacaca	0.203													6	3	---	---	---	---	
ACACA	31	broad.mit.edu	37	17	35601862	35601863	+	Intron	INS	-	A	A			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35601862_35601863insA	uc002hnm.2	-						ACACA_uc002hnk.2_Intron|ACACA_uc002hnl.2_Intron|ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc010cuz.2_Intron	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CAGGCACAAATACAAGGCATAA	0.376													157	73	---	---	---	---	
RNF157	114804	broad.mit.edu	37	17	74160693	74160693	+	Intron	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74160693delA	uc002jqz.2	-						RNF157_uc002jra.2_Intron	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157								zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			TTCTTTGATTaaaaaaaaaaa	0.224													7	4	---	---	---	---	
TMC6	11322	broad.mit.edu	37	17	76127849	76127850	+	Intron	INS	-	G	G	rs146880338	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76127849_76127850insG	uc002jul.1	-						TMC6_uc010dhf.1_5'Flank|TMC6_uc002juk.2_5'Flank|TMC6_uc010dhg.1_5'Flank|TMC6_uc002jun.3_5'Flank|TMC6_uc002juo.2_5'Flank|TMC6_uc010wtq.1_5'Flank|TMC8_uc010dhh.1_Intron|TMC8_uc002jup.2_Intron|TMC8_uc002juq.2_Intron|TMC8_uc010wtr.1_5'Flank	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6							endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGACGGTGCGTGGGGGGGGTGC	0.743									Epidermodysplasia_Verruciformis_Familial_Clustering_of				6	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	18	15198505	15198508	+	IGR	DEL	TTTG	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:15198505_15198508delTTTG								ANKRD30B (345768 upstream) : LOC644669 (115047 downstream)																							CACATTCTGATTTGTTTTTTGTAT	0.358													11	5	---	---	---	---	
TMX3	54495	broad.mit.edu	37	18	66344507	66344507	+	Intron	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:66344507delA	uc002lkf.2	-						TMX3_uc010xez.1_Intron	NM_019022	NP_061895	Q96JJ7	TMX3_HUMAN	thioredoxin domain containing 10 precursor						cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			skin(1)	1						ACTTGAAACCACTATAGATTT	0.333													20	12	---	---	---	---	
Unknown	0	broad.mit.edu	37	19	16823289	16823289	+	IGR	DEL	T	-	-	rs36044959		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16823289delT								TMEM38A (23475 upstream) : NWD1 (7498 downstream)																							tttcatttccttttttttttt	0.134													5	3	---	---	---	---	
CAPN12	147968	broad.mit.edu	37	19	39232226	39232227	+	Intron	INS	-	A	A	rs117178118		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39232226_39232227insA	uc002ojd.1	-							NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12						proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			caaaaaaaaagaaaaaaaaaaa	0.208													4	2	---	---	---	---	
NUCB1	4924	broad.mit.edu	37	19	49422520	49422520	+	Frame_Shift_Del	DEL	G	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49422520delG	uc002plb.3	+	10	1051	c.979delG	c.(979-981)GGGfs	p.G327fs	NUCB1_uc002pla.2_Frame_Shift_Del_p.G327fs|NUCB1_uc002plc.2_Frame_Shift_Del_p.G327fs|NUCB1_uc002pld.2_5'UTR	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	nucleobindin 1 precursor	327	EF-hand 2.					ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding				0		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		GAAGGAGTTTGGGGACACCGG	0.582													63	58	---	---	---	---	
RBL1	5933	broad.mit.edu	37	20	35696195	35696195	+	Intron	DEL	C	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35696195delC	uc002xgi.2	-						RBL1_uc010zvt.1_Intron|RBL1_uc002xgj.1_Intron|RBL1_uc010gfv.1_Intron	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a						cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				aaaaaaaaaaCAACAACAGAA	0.124													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	20	37268742	37268750	+	IGR	DEL	TCTTCCTCC	-	-	rs146443168	by1000genomes	TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37268742_37268750delTCTTCCTCC								ADIG (51638 upstream) : SLC32A1 (84355 downstream)																							ttcttcttcttcttcctcctcttcttcct	0.220													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	21	44756755	44756755	+	IGR	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44756755delA								CRYAA (163842 upstream) : SIK1 (77643 downstream)																							caccatcaccaccaccatcac	0.000													4	2	---	---	---	---	
CECR2	27443	broad.mit.edu	37	22	17983635	17983636	+	Intron	INS	-	TT	TT	rs35041905		TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17983635_17983636insTT	uc010gqw.1	+						CECR2_uc010gqv.1_Intron|CECR2_uc002zml.2_Intron|CECR2_uc002zmm.1_Intron	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2						chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		cgcccggctaattttttttttt	0.000													3	3	---	---	---	---	
SEZ6L	23544	broad.mit.edu	37	22	26744480	26744495	+	Intron	DEL	GAAGGAAGGAAGGAAG	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26744480_26744495delGAAGGAAGGAAGGAAG	uc003acb.2	+						SEZ6L_uc003acc.2_Intron|SEZ6L_uc011akc.1_Intron|SEZ6L_uc003acd.2_Intron|SEZ6L_uc011akd.1_Intron|SEZ6L_uc003ace.2_Intron|SEZ6L_uc003acf.1_Intron|SEZ6L_uc010gvc.1_Intron|SEZ6L_uc011ake.1_Intron	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like							endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GGGAGAGAGAgaaggaaggaaggaaggaaggaagga	0.069													4	2	---	---	---	---	
STS	412	broad.mit.edu	37	X	7193971	7193971	+	Intron	DEL	T	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:7193971delT	uc004cry.3	+							NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor						female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	ttttcctcccttttttttttt	0.373									Ichthyosis				4	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	X	71492424	71492424	+	IGR	DEL	A	-	-			TCGA-22-0944-01	TCGA-22-0944-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71492424delA								PIN4 (7612 upstream) : RPS4X (30 downstream)																							AAACTGAATTAAAAAAAAAAA	0.383													6	3	---	---	---	---	
