Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
PRAMEF6	440561	broad.mit.edu	37	1	13001287	13001287	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:13001287T>A	uc001auq.2	-	3	482	c.396A>T	c.(394-396)AAA>AAT	p.K132N	PRAMEF5_uc001aur.2_Intron	NM_001010889	NP_001010889	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	132											0	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCACTGGTGTTTTGTTCCTCT	0.493													26	849	---	---	---	---	PASS
MAN1C1	57134	broad.mit.edu	37	1	26104631	26104631	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26104631G>A	uc001bkm.2	+	9	1623	c.1293G>A	c.(1291-1293)GGG>GGA	p.G431G	MAN1C1_uc009vry.1_Silent_p.G251G|MAN1C1_uc001bkn.2_5'Flank	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	431	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		TCTCTCCCGGGGGGCTGACCT	0.642													33	55	---	---	---	---	PASS
TMEM39B	55116	broad.mit.edu	37	1	32542890	32542890	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32542890C>T	uc010ogv.1	+	5	707	c.561C>T	c.(559-561)TCC>TCT	p.S187S	TMEM39B_uc010ogt.1_Intron|TMEM39B_uc010ogu.1_Silent_p.S60S|TMEM39B_uc001bue.3_Silent_p.S187S|TMEM39B_uc001buf.3_Intron|TMEM39B_uc010ogw.1_Intron	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	187	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GGACCTACTCCTTCCTGAACC	0.597													28	80	---	---	---	---	PASS
TIE1	7075	broad.mit.edu	37	1	43775130	43775130	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43775130C>G	uc001ciu.2	+	9	1339	c.1260C>G	c.(1258-1260)GAC>GAG	p.D420E	TIE1_uc010okd.1_Missense_Mutation_p.D420E|TIE1_uc010oke.1_Missense_Mutation_p.D375E|TIE1_uc009vwq.2_Missense_Mutation_p.D376E|TIE1_uc010okf.1_Missense_Mutation_p.D65E|TIE1_uc010okg.1_Missense_Mutation_p.D65E|TIE1_uc010okc.1_3'UTR	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	420	Ig-like C2-type 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTCTTGCGGACAGTGGGTTCT	0.582													27	40	---	---	---	---	PASS
DMAP1	55929	broad.mit.edu	37	1	44685876	44685876	+	Silent	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44685876C>G	uc001clq.1	+	10	1319	c.1239C>G	c.(1237-1239)GGC>GGG	p.G413G	DMAP1_uc001clr.1_Silent_p.G413G|DMAP1_uc001cls.1_Silent_p.G413G|DMAP1_uc010oku.1_Silent_p.G403G	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	413					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					CAGCATCAGGCCCAGGCCCGG	0.662											OREG0013438	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	11	---	---	---	---	PASS
PIK3R3	8503	broad.mit.edu	37	1	46521483	46521483	+	Nonsense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46521483G>A	uc001cpb.3	-	7	1681	c.925C>T	c.(925-927)CGA>TGA	p.R309*	PIK3R3_uc009vyb.2_Intron|PIK3R3_uc009vyc.2_Nonsense_Mutation_p.R326*|PIK3R3_uc001cpc.3_Nonsense_Mutation_p.R309*|PIK3R3_uc010olw.1_Nonsense_Mutation_p.R355*|PIK3R3_uc010olv.1_Nonsense_Mutation_p.R99*	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	309					insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TGTTGATCTCGGATCTTTCGC	0.458													6	237	---	---	---	---	PASS
DAB1	1600	broad.mit.edu	37	1	57476474	57476474	+	Intron	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57476474A>G	uc001cys.1	-						DAB1_uc001cyt.1_Intron|DAB1_uc001cyq.1_Intron|DAB1_uc001cyr.1_Intron|DAB1_uc009vzw.1_Intron|DAB1_uc009vzx.1_Intron	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1						cell differentiation|nervous system development					skin(2)|ovary(1)	3						CTAGAACACAAGAAGATAATA	0.423													24	72	---	---	---	---	PASS
DOCK7	85440	broad.mit.edu	37	1	63044487	63044487	+	Intron	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:63044487A>G	uc001daq.2	-						DOCK7_uc001dan.2_Intron|DOCK7_uc001dao.2_Intron|DOCK7_uc001dap.2_Intron	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7						activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						ATATTGAACCAAAAGGACTCA	0.274													62	139	---	---	---	---	PASS
TCTEX1D1	200132	broad.mit.edu	37	1	67236120	67236120	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67236120T>C	uc001dcv.2	+	3	301	c.170T>C	c.(169-171)ATC>ACC	p.I57T	TCTEX1D1_uc009wau.2_RNA|TCTEX1D1_uc009wav.2_RNA	NM_152665	NP_689878	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	57											0						CGTGATGATATCTCTCGCCTT	0.338													69	257	---	---	---	---	PASS
SLC44A5	204962	broad.mit.edu	37	1	75684328	75684328	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75684328T>C	uc001dgu.2	-	17	1520	c.1376A>G	c.(1375-1377)TAC>TGC	p.Y459C	SLC44A5_uc001dgt.2_Missense_Mutation_p.Y459C|SLC44A5_uc001dgs.2_Missense_Mutation_p.Y417C|SLC44A5_uc001dgr.2_Missense_Mutation_p.Y417C|SLC44A5_uc010oqz.1_Missense_Mutation_p.Y498C|SLC44A5_uc010ora.1_Missense_Mutation_p.Y453C|SLC44A5_uc010orb.1_Missense_Mutation_p.Y329C	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	459	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						AAATAAGTTGTATACATGGAA	0.433													40	83	---	---	---	---	PASS
USP33	23032	broad.mit.edu	37	1	78163019	78163019	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78163019C>T	uc001dht.2	-	25	3159	c.2812G>A	c.(2812-2814)GAA>AAA	p.E938K	USP33_uc009wca.1_RNA|USP33_uc001dhs.2_3'UTR|USP33_uc001dhu.2_Missense_Mutation_p.E907K	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	938					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						GACCGAGTTTCTACTTCAATT	0.398													39	127	---	---	---	---	PASS
COL24A1	255631	broad.mit.edu	37	1	86306919	86306919	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86306919G>C	uc001dlj.2	-	42	3655	c.3613C>G	c.(3613-3615)CCT>GCT	p.P1205A	COL24A1_uc001dli.2_Missense_Mutation_p.P341A|COL24A1_uc010osd.1_Missense_Mutation_p.P505A|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1205	Collagen-like 13.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCACCTCGAGGCCCAGGTGGT	0.318													23	73	---	---	---	---	PASS
DNTTIP2	30836	broad.mit.edu	37	1	94338777	94338777	+	Intron	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94338777A>G	uc001dqf.2	-						DNTTIP2_uc010otm.1_Intron	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		GAAGCTATAAAAACATAAAAT	0.264													21	55	---	---	---	---	PASS
LPPR4	9890	broad.mit.edu	37	1	99771562	99771562	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:99771562A>G	uc001dse.2	+	7	1394	c.1288A>G	c.(1288-1290)AGA>GGA	p.R430G	LPPR4_uc010oue.1_Missense_Mutation_p.R372G	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	430							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGACCCTGTCAGAAGAAATGC	0.493													33	65	---	---	---	---	PASS
VCAM1	7412	broad.mit.edu	37	1	101196814	101196814	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101196814C>A	uc001dti.2	+	6	1385	c.1265C>A	c.(1264-1266)ACT>AAT	p.T422N	VCAM1_uc001dtj.2_Missense_Mutation_p.T330N|VCAM1_uc010ouj.1_Missense_Mutation_p.T360N	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	422	Ig-like C2-type 5.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AGCTCTGTCACTGTAAGCTGC	0.448													30	69	---	---	---	---	PASS
FAM40A	85369	broad.mit.edu	37	1	110594511	110594511	+	Splice_Site	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110594511T>A	uc001dza.1	+	20	2285	c.2266_splice	c.e20+2	p.D756_splice	FAM40A_uc001dyz.1_Splice_Site_p.D661_splice|FAM40A_uc009wfp.1_Splice_Site_p.D580_splice	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369							nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		ACGGCAATGGTGAGACTCTGC	0.562													20	44	---	---	---	---	PASS
SPAG17	200162	broad.mit.edu	37	1	118548128	118548128	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118548128T>C	uc001ehk.2	-	32	4753	c.4685A>G	c.(4684-4686)AAG>AGG	p.K1562R		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1562						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTGCTCACGCTTTTGAAAAGG	0.448													25	83	---	---	---	---	PASS
SPAG17	200162	broad.mit.edu	37	1	118554860	118554860	+	Nonsense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118554860G>A	uc001ehk.2	-	30	4491	c.4423C>T	c.(4423-4425)CAA>TAA	p.Q1475*		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1475						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTTGTTTCTTGATCATCTGGC	0.338													46	114	---	---	---	---	PASS
PDE4DIP	9659	broad.mit.edu	37	1	144879133	144879133	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:144879133C>G	uc001elw.3	-	27	4608	c.4317G>C	c.(4315-4317)GAG>GAC	p.E1439D	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E1395D|PDE4DIP_uc001elv.3_Missense_Mutation_p.E446D	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1439	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GGATGAGACTCTCCAGGTCCT	0.562			T	PDGFRB	MPD								45	208	---	---	---	---	PASS
LOC200030	200030	broad.mit.edu	37	1	148344739	148344739	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:148344739T>A	uc001eqf.2	-	2	214	c.179A>T	c.(178-180)TAT>TTT	p.Y60F	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|NBPF14_uc009wkf.1_Intron|uc001erd.3_Missense_Mutation_p.Y60F|uc001erc.3_Intron|uc010paj.1_Intron|uc010pau.1_5'Flank|uc010pav.1_Missense_Mutation_p.Y60F|uc010paw.1_Intron	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	60						cytoplasm					0						ACACTCTTCATAGTCTGAGAA	0.517													15	378	---	---	---	---	PASS
FLG	2312	broad.mit.edu	37	1	152281121	152281121	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152281121C>G	uc001ezu.1	-	3	6277	c.6241G>C	c.(6241-6243)GGG>CGG	p.G2081R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2081	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCTTTCCCCTGACTGGCCA	0.567									Ichthyosis				7	474	---	---	---	---	PASS
NPR1	4881	broad.mit.edu	37	1	153659831	153659831	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153659831C>A	uc001fcs.3	+	13	2512	c.2091C>A	c.(2089-2091)GCC>GCA	p.A697A	NPR1_uc010pdz.1_Silent_p.A443A|NPR1_uc010pea.1_Silent_p.A175A	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	697	Cytoplasmic (Potential).|Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CCGTTTATGCCAGTGAGCCTT	0.512													21	35	---	---	---	---	PASS
EFNA3	1944	broad.mit.edu	37	1	155058639	155058639	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155058639C>A	uc001fhf.2	+	4	614	c.544C>A	c.(544-546)CCC>ACC	p.P182T	EFNA3_uc010pew.1_Missense_Mutation_p.P177T|EFNA3_uc010pex.1_Intron|EFNA3_uc001fhg.2_Missense_Mutation_p.P159T	NM_004952	NP_004943	P52797	EFNA3_HUMAN	ephrin A3 precursor	182					cell-cell signaling	anchored to membrane|integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity				0	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		all cancers(21;5.67e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000284)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCCCACTCTCCCCCAGTTCAC	0.692											OREG0013850	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	39	---	---	---	---	PASS
MEX3A	92312	broad.mit.edu	37	1	156047322	156047322	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156047322C>A	uc001fnd.3	-	2	606	c.606G>T	c.(604-606)ATG>ATT	p.M202I		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	202						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					AGGCACGGATCATGGAGAAGT	0.667													5	17	---	---	---	---	PASS
FCRL3	115352	broad.mit.edu	37	1	157667699	157667699	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:157667699G>T	uc001frb.2	-	5	601	c.309C>A	c.(307-309)ATC>ATA	p.I103I	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.I103I|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Silent_p.I103I	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	103	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					AAGCCTGCAGGATCAGCCAGT	0.463													25	34	---	---	---	---	PASS
OR10Z1	128368	broad.mit.edu	37	1	158576965	158576965	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158576965C>G	uc010pio.1	+	1	737	c.737C>G	c.(736-738)ACA>AGA	p.T246R		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TCGCACCTTACAGTGGTCATT	0.502													79	187	---	---	---	---	PASS
OR6K2	81448	broad.mit.edu	37	1	158670043	158670043	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158670043T>C	uc001fsu.1	-	1	400	c.400A>G	c.(400-402)ATC>GTC	p.I134V		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					GGGGTCATGATAGAGGGATAA	0.478													36	71	---	---	---	---	PASS
OR10J3	441911	broad.mit.edu	37	1	159284278	159284278	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159284278T>A	uc010piu.1	-	1	172	c.172A>T	c.(172-174)ACC>TCC	p.T58S		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					TACATGGGGGTGTGAAGATGA	0.453													60	136	---	---	---	---	PASS
FCGR2C	9103	broad.mit.edu	37	1	161560953	161560953	+	Silent	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161560953C>G	uc001gav.2	+	5	510	c.411C>G	c.(409-411)ACC>ACG	p.T137T	FCGR2C_uc009wuj.2_RNA|FCGR2C_uc009wuk.2_RNA	NM_201563	NP_963857			Fc fragment of IgG, low affinity IIc, receptor												0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TGCTCCAGACCCCTCACCTGG	0.552													5	16	---	---	---	---	PASS
C1orf110	339512	broad.mit.edu	37	1	162824606	162824606	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162824606C>A	uc001gck.2	-	4	1033	c.858G>T	c.(856-858)AGG>AGT	p.R286S	C1orf110_uc009wuw.1_Intron|C1orf110_uc009wux.1_Missense_Mutation_p.R285S	NM_178550	NP_848645	Q86UF4	CA110_HUMAN	hypothetical protein LOC339512	286											0						CCTTTCCTGCCCTGGATGATG	0.468													49	94	---	---	---	---	PASS
TADA1	117143	broad.mit.edu	37	1	166839015	166839015	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:166839015G>A	uc001gdw.2	-	2	335	c.151C>T	c.(151-153)CTC>TTC	p.L51F	TADA1_uc009wve.2_Missense_Mutation_p.L51F	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	51					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1						TCCTGTGTGAGAAGTCTATGA	0.353													71	182	---	---	---	---	PASS
MAEL	84944	broad.mit.edu	37	1	166987183	166987183	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:166987183C>A	uc001gdy.1	+	10	1099	c.1028C>A	c.(1027-1029)GCA>GAA	p.A343E	MAEL_uc001gdz.1_Missense_Mutation_p.A312E|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	343					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						GTATTGGATGCAGGGCGTTAC	0.458													33	96	---	---	---	---	PASS
F5	2153	broad.mit.edu	37	1	169510187	169510187	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169510187G>T	uc001ggg.1	-	13	4286	c.4141C>A	c.(4141-4143)CAG>AAG	p.Q1381K		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1381	B.|2-22.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGGTTTGTCTGACTGAGTTCT	0.537													85	128	---	---	---	---	PASS
TNN	63923	broad.mit.edu	37	1	175092777	175092777	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175092777G>T	uc001gkl.1	+	12	3005	c.2892G>T	c.(2890-2892)AAG>AAT	p.K964N		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	964	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGAGCAAGAAGGCTGACACCA	0.617													34	80	---	---	---	---	PASS
TNR	7143	broad.mit.edu	37	1	175355202	175355202	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175355202G>T	uc001gkp.1	-	6	1824	c.1743C>A	c.(1741-1743)AAC>AAA	p.N581K	TNR_uc009wwu.1_Missense_Mutation_p.N581K	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	581	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AATCGCTCTCGTTGGTCCCTC	0.632													40	103	---	---	---	---	PASS
FAM5B	57795	broad.mit.edu	37	1	177250056	177250056	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:177250056C>T	uc001glf.2	+	8	2056	c.1744C>T	c.(1744-1746)CTG>TTG	p.L582L	FAM5B_uc001glg.2_Silent_p.L477L	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	582						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GAACAGCACCCTGGAGCCTGT	0.567													13	34	---	---	---	---	PASS
RALGPS2	55103	broad.mit.edu	37	1	178745918	178745918	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:178745918C>A	uc001glz.2	+	2	357	c.19C>A	c.(19-21)CAG>AAG	p.Q7K	RALGPS2_uc001gly.1_Missense_Mutation_p.Q7K|RALGPS2_uc010pnb.1_Missense_Mutation_p.Q7K	NM_152663	NP_689876	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	7					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0						AATGAACGGGCAGGCAAGCAG	0.423													14	40	---	---	---	---	PASS
CEP350	9857	broad.mit.edu	37	1	179989082	179989082	+	Splice_Site	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:179989082A>G	uc001gnt.2	+	12	2558	c.2175_splice	c.e12-2	p.R725_splice	CEP350_uc009wxl.2_Splice_Site_p.R724_splice|CEP350_uc001gnu.2_Splice_Site_p.R559_splice	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350							centrosome|nucleus|spindle				ovary(4)	4						TTTCATTTCCAGAAAAGACTT	0.294													48	126	---	---	---	---	PASS
TPR	7175	broad.mit.edu	37	1	186331476	186331476	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186331476T>A	uc001grv.2	-	7	1030	c.733A>T	c.(733-735)ACA>TCA	p.T245S	TPR_uc010pop.1_Missense_Mutation_p.T321S	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	245	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TCATTTGATGTTTTTAAGCCA	0.318			T	NTRK1	papillary thyroid								38	68	---	---	---	---	PASS
FAM5C	339479	broad.mit.edu	37	1	190250791	190250791	+	Missense_Mutation	SNP	C	T	T	rs144952455		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:190250791C>T	uc001gse.1	-	3	558	c.326G>A	c.(325-327)CGC>CAC	p.R109H	FAM5C_uc010pot.1_Intron	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	109						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TCTTATGTTGCGGAAGAATTC	0.448													46	107	---	---	---	---	PASS
CFHR1	3078	broad.mit.edu	37	1	196797367	196797367	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196797367C>G	uc001gtn.2	+	4	712	c.598C>G	c.(598-600)CAA>GAA	p.Q200E	CFHR1_uc001gtm.2_Missense_Mutation_p.Q104E	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	200	Sushi 3.				complement activation	extracellular space					0						AGAACCACCTCAATGCAAAGG	0.338													4	237	---	---	---	---	PASS
CFHR4	10877	broad.mit.edu	37	1	196887531	196887531	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196887531G>T	uc001gto.2	+	6	1060	c.991G>T	c.(991-993)GAA>TAA	p.E331*	CFHR4_uc009wyy.2_Nonsense_Mutation_p.E577*|CFHR4_uc001gtp.2_Nonsense_Mutation_p.E578*	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	331	Sushi 5.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						CCCCAGATGCGAATAAGGCAG	0.373													43	142	---	---	---	---	PASS
CFHR5	81494	broad.mit.edu	37	1	196946815	196946815	+	Silent	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196946815A>T	uc001gts.3	+	1	149	c.21A>T	c.(19-21)GTA>GTT	p.V7V		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	7					complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TATTCAGTGTAATCCTAATCT	0.353													56	130	---	---	---	---	PASS
ASPM	259266	broad.mit.edu	37	1	197072093	197072093	+	Silent	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197072093T>A	uc001gtu.2	-	18	6545	c.6288A>T	c.(6286-6288)ACA>ACT	p.T2096T	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2096	IQ 16.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTTTAATTGCTGTCTTCTTCA	0.333													61	155	---	---	---	---	PASS
CRB1	23418	broad.mit.edu	37	1	197390630	197390630	+	Missense_Mutation	SNP	A	T	T	rs115811272	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197390630A>T	uc001gtz.2	+	6	1807	c.1672A>T	c.(1672-1674)ATT>TTT	p.I558F	CRB1_uc010poz.1_Missense_Mutation_p.I489F|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.I446F|CRB1_uc010ppb.1_Missense_Mutation_p.I558F|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.I39F|CRB1_uc001gub.1_Missense_Mutation_p.I207F	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	558	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GCTTCTGTTCATTTCCCACAA	0.453													55	144	---	---	---	---	PASS
NEK2	4751	broad.mit.edu	37	1	211836894	211836894	+	Silent	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:211836894G>C	uc001hir.1	-	8	1358	c.1212C>G	c.(1210-1212)CTC>CTG	p.L404L	NEK2_uc001hiq.1_Silent_p.L396L	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	404	Necessary for interaction with MAD1L1.|Interaction with SAV1 and STK3.|Interaction with PCNT.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		ACTTAGATGTGAGCTGACTCT	0.423													36	87	---	---	---	---	PASS
ANGEL2	90806	broad.mit.edu	37	1	213173694	213173694	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213173694T>C	uc001hjz.2	-	7	1448	c.1293A>G	c.(1291-1293)CAA>CAG	p.Q431Q	ANGEL2_uc010pto.1_Silent_p.Q305Q|ANGEL2_uc010ptp.1_Silent_p.Q305Q|ANGEL2_uc001hka.2_Silent_p.Q262Q|ANGEL2_uc010ptq.1_RNA	NM_144567	NP_653168	Q5VTE6	ANGE2_HUMAN	LOC90806 protein	431											0				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		GGACCTCTGTTTGCTTCAGCT	0.338													33	94	---	---	---	---	PASS
USH2A	7399	broad.mit.edu	37	1	216166490	216166490	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216166490C>A	uc001hku.1	-	35	7064	c.6677G>T	c.(6676-6678)TGC>TTC	p.C2226F		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2226	Extracellular (Potential).|Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACTCACTGTGCACCCACCACC	0.478										HNSCC(13;0.011)	OREG0014251	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	100	---	---	---	---	PASS
BPNT1	10380	broad.mit.edu	37	1	220253147	220253147	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220253147G>A	uc001hma.2	-	2	214	c.42C>T	c.(40-42)TCC>TCT	p.S14S	BPNT1_uc010pug.1_Intron|BPNT1_uc010puh.1_Silent_p.S14S|BPNT1_uc001hmb.3_Silent_p.S14S	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	14					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		TAGAATATGCGGAGGCTACCA	0.418													42	83	---	---	---	---	PASS
IARS2	55699	broad.mit.edu	37	1	220310241	220310241	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220310241T>C	uc001hmc.2	+	16	2141	c.2037T>C	c.(2035-2037)GTT>GTC	p.V679V	IARS2_uc001hmd.2_Silent_p.V15V	NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	679					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	ATGTTGTCGTTAATGGAGGAC	0.368													26	60	---	---	---	---	PASS
MARK1	4139	broad.mit.edu	37	1	220773197	220773197	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220773197C>T	uc001hmn.3	+	5	1013	c.416C>T	c.(415-417)GCG>GTG	p.A139V	MARK1_uc009xdw.2_Missense_Mutation_p.A139V|MARK1_uc010pun.1_Missense_Mutation_p.A139V|MARK1_uc001hmm.3_Intron	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	139	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		ATGGAATACGCGAGTGGGGGT	0.338													5	200	---	---	---	---	PASS
DISP1	84976	broad.mit.edu	37	1	223179195	223179195	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223179195A>T	uc001hnu.1	+	8	4603	c.4456A>T	c.(4456-4458)ATT>TTT	p.I1486F		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1486					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TTGTGGCAGAATTGTGAGAGT	0.403													50	79	---	---	---	---	PASS
LBR	3930	broad.mit.edu	37	1	225599054	225599054	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:225599054G>A	uc001hoy.2	-	9	1316	c.1173C>T	c.(1171-1173)CCC>CCT	p.P391P	LBR_uc001hoz.2_Silent_p.P391P|LBR_uc001hpa.1_Silent_p.P391P	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	391	Helical; (Potential).				cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		CAATCAATCCGGGGCGCAATT	0.348													82	151	---	---	---	---	PASS
GNPAT	8443	broad.mit.edu	37	1	231406507	231406507	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231406507A>C	uc001hup.3	+	10	1489	c.1283A>C	c.(1282-1284)AAT>ACT	p.N428T	GNPAT_uc009xfp.2_Missense_Mutation_p.N367T	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	428					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TGTGTAGATAATAAACCTGCT	0.458													55	130	---	---	---	---	PASS
PCNXL2	80003	broad.mit.edu	37	1	233394065	233394065	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233394065C>A	uc001hvl.2	-	5	1778	c.1543G>T	c.(1543-1545)GAC>TAC	p.D515Y	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	515						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GACGATGGGTCAAGGTTAGTC	0.522													25	70	---	---	---	---	PASS
GPR137B	7107	broad.mit.edu	37	1	236306297	236306297	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236306297G>T	uc001hxq.2	+	1	466	c.375G>T	c.(373-375)CAG>CAT	p.Q125H		NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	125	Helical; (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TGTGCCTGCAGTTTTTCACCC	0.602													51	123	---	---	---	---	PASS
MTR	4548	broad.mit.edu	37	1	236978973	236978973	+	Intron	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236978973A>G	uc001hyi.3	+						MTR_uc010pxv.1_Intron|MTR_uc010pxw.1_Intron|MTR_uc010pxx.1_Intron|MTR_uc010pxy.1_Intron|MTR_uc009xgj.1_Intron	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine						nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	TGTAAGTTCTAAAGTGTTTGC	0.363													29	74	---	---	---	---	PASS
MTR	4548	broad.mit.edu	37	1	237016389	237016389	+	Splice_Site	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237016389G>A	uc001hyi.3	+	18	2376	c.1953_splice	c.e18+1	p.Q651_splice	MTR_uc010pxw.1_Splice_Site_p.Q244_splice|MTR_uc010pxx.1_Splice_Site_p.Q651_splice|MTR_uc010pxy.1_Intron	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine						nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	TTATGCCCAGGTAGAGAGACA	0.403													47	111	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237754047	237754047	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237754047C>A	uc001hyl.1	+	31	4035	c.3915C>A	c.(3913-3915)AGC>AGA	p.S1305R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1305	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCGCCTGAGCATGCCGATCG	0.507													98	185	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237951425	237951425	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237951425A>T	uc001hyl.1	+	92	13586	c.13466A>T	c.(13465-13467)CAG>CTG	p.Q4489L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4489					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCATATCAACAGAAACTTCTA	0.393													13	27	---	---	---	---	PASS
FMN2	56776	broad.mit.edu	37	1	240370980	240370980	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240370980G>T	uc010pyd.1	+	5	3093	c.2868G>T	c.(2866-2868)CCG>CCT	p.P956P	FMN2_uc010pye.1_Silent_p.P960P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	956	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TACCCCCTCCGCCCCCTCTTC	0.697													11	19	---	---	---	---	PASS
GREM2	64388	broad.mit.edu	37	1	240656540	240656540	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240656540C>G	uc001hys.2	-	2	516	c.236G>C	c.(235-237)CGG>CCG	p.R79P		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	79	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			CACCGTCTGCCGCAGCGGCTG	0.642													6	23	---	---	---	---	PASS
RGS7	6000	broad.mit.edu	37	1	241094077	241094077	+	Intron	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:241094077T>A	uc001hyv.2	-						RGS7_uc010pyh.1_Intron|RGS7_uc010pyj.1_Intron|RGS7_uc001hyu.2_Intron|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Intron	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7						G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GTCTGCGGAATGAAAAGAAGT	0.373													75	163	---	---	---	---	PASS
PLD5	200150	broad.mit.edu	37	1	242383334	242383334	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242383334C>A	uc001hzn.1	-	5	818	c.691G>T	c.(691-693)GTG>TTG	p.V231L	PLD5_uc001hzl.3_Missense_Mutation_p.V169L|PLD5_uc001hzm.3_Missense_Mutation_p.V21L|PLD5_uc001hzo.1_Missense_Mutation_p.V139L			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	231	PLD phosphodiesterase 1.					integral to membrane	catalytic activity	p.S231R(1)		ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CCGATATACACGTGCTGTTTG	0.522													24	58	---	---	---	---	PASS
OR1C1	26188	broad.mit.edu	37	1	247920944	247920944	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247920944G>T	uc010pza.1	-	1	765	c.765C>A	c.(763-765)GCC>GCA	p.A255A		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AGACGGCGATGGCTGTGCCGT	0.522													20	34	---	---	---	---	PASS
OR2T6	254879	broad.mit.edu	37	1	248551514	248551514	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248551514G>A	uc001iei.1	+	1	605	c.605G>A	c.(604-606)TGC>TAC	p.C202Y		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	202	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGTATGTGTGCTGCGTTGCA	0.517													16	50	---	---	---	---	PASS
KCNF1	3754	broad.mit.edu	37	2	11052594	11052594	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11052594C>G	uc002rax.2	+	1	532	c.42C>G	c.(40-42)AGC>AGG	p.S14R		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	14	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		AGCCGGGCAGCCAGAGCTCCG	0.537													4	4	---	---	---	---	PASS
C2orf79	391356	broad.mit.edu	37	2	25015984	25015984	+	Intron	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25015984G>A	uc002rfm.2	-						CENPO_uc002rfn.2_5'Flank|CENPO_uc002rfo.1_5'Flank|CENPO_uc002rfp.1_5'Flank|CENPO_uc002rfq.1_5'Flank	NM_001013663	NP_001013685	Q6GMV3	PTRD1_HUMAN	hypothetical protein LOC391356						translation		aminoacyl-tRNA hydrolase activity|protein tyrosine phosphatase activity				0						CCCTCCGCCCGAGTGCCTCAC	0.692													10	13	---	---	---	---	PASS
EMILIN1	11117	broad.mit.edu	37	2	27305106	27305106	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27305106C>T	uc002rii.3	+	4	1095	c.667C>T	c.(667-669)CAG>TAG	p.Q223*	EMILIN1_uc010eyq.1_Nonsense_Mutation_p.Q223*|EMILIN1_uc002rik.3_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	223	Potential.				cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGGGAGGCAGCAGCCAGCTGA	0.672													15	42	---	---	---	---	PASS
TCF23	150921	broad.mit.edu	37	2	27375610	27375610	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27375610G>A	uc010ylg.1	+	3	520	c.520G>A	c.(520-522)GAC>AAC	p.D174N		NM_175769	NP_786951	Q7RTU1	TCF23_HUMAN	transcription factor 23	174					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCGATCTTGACTCCACCAC	0.567													31	63	---	---	---	---	PASS
SLC5A6	8884	broad.mit.edu	37	2	27429763	27429763	+	Silent	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27429763C>G	uc002rjd.2	-	4	832	c.441G>C	c.(439-441)GTG>GTC	p.V147V	SLC5A6_uc010eyv.1_Silent_p.V147V	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	147	Helical; (Potential).				biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	AGATGAAGGTCACAGTTCCAC	0.473													148	356	---	---	---	---	PASS
GCKR	2646	broad.mit.edu	37	2	27721620	27721620	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27721620G>A	uc002rky.2	+	5	450	c.384G>A	c.(382-384)CTG>CTA	p.L128L	GCKR_uc010ezd.2_Silent_p.L128L|GCKR_uc010ylu.1_5'UTR	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	128	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					TGAAAGGTCTGGGACAGAAAC	0.393													47	72	---	---	---	---	PASS
ALK	238	broad.mit.edu	37	2	29446232	29446232	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:29446232G>T	uc002rmy.2	-	20	4242	c.3335C>A	c.(3334-3336)CCG>CAG	p.P1112Q	ALK_uc010ymo.1_Missense_Mutation_p.P44Q	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1112	Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTTTTTCCGCGGCACCTCCTT	0.582			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				18	72	---	---	---	---	PASS
SLC8A1	6546	broad.mit.edu	37	2	40366621	40366621	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:40366621G>A	uc002rrx.2	-	9	2489	c.2465C>T	c.(2464-2466)GCT>GTT	p.A822V	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.A817V|SLC8A1_uc002rrz.2_Missense_Mutation_p.A809V|SLC8A1_uc002rsa.2_Missense_Mutation_p.A786V|SLC8A1_uc002rsd.3_Missense_Mutation_p.A786V	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	822	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AAAGTGGGAAGCCAGGTCTCC	0.493													21	51	---	---	---	---	PASS
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48872250	48872250	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48872250G>T	uc010yol.1	+						STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.V832L|GTF2A1L_uc002rws.1_Missense_Mutation_p.V128L|GTF2A1L_uc010yom.1_Missense_Mutation_p.V94L|GTF2A1L_uc002rwt.2_Missense_Mutation_p.V128L	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1						endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACTACAGACTGTATCTGGTGA	0.328													72	96	---	---	---	---	PASS
BCL11A	53335	broad.mit.edu	37	2	60687767	60687767	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:60687767G>A	uc002sae.1	-	4	2508	c.2280C>T	c.(2278-2280)CAC>CAT	p.H760H	BCL11A_uc002sab.2_Intron|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Silent_p.H726H|BCL11A_uc002sad.1_Silent_p.H608H|BCL11A_uc002saf.1_Silent_p.H726H	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	760	C2H2-type 4.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GGCTTCTCCTGTGGACAGTGA	0.562			T	IGH@	B-CLL								55	516	---	---	---	---	PASS
BCL11A	53335	broad.mit.edu	37	2	60688956	60688956	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:60688956T>A	uc002sae.1	-	4	1319	c.1091A>T	c.(1090-1092)CAA>CTA	p.Q364L	BCL11A_uc002sab.2_Missense_Mutation_p.Q364L|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.Q330L|BCL11A_uc002sad.1_Missense_Mutation_p.Q212L|BCL11A_uc002saf.1_Missense_Mutation_p.Q330L	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	364	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			AGGGGCGGATTGCAGAGGAGG	0.642			T	IGH@	B-CLL								23	326	---	---	---	---	PASS
USP34	9736	broad.mit.edu	37	2	61561116	61561116	+	Intron	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61561116C>A	uc002sbe.2	-							NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34						positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TCTGAAACAGCAGAAACATTC	0.299													20	120	---	---	---	---	PASS
ZNF638	27332	broad.mit.edu	37	2	71576311	71576311	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71576311A>T	uc002shx.2	+	2	546	c.227A>T	c.(226-228)CAC>CTC	p.H76L	ZNF638_uc010fec.2_Missense_Mutation_p.H182L|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Missense_Mutation_p.H76L|ZNF638_uc002shy.2_Missense_Mutation_p.H76L|ZNF638_uc002shz.2_Missense_Mutation_p.H76L|ZNF638_uc002sia.2_Missense_Mutation_p.H76L|ZNF638_uc002sib.1_Missense_Mutation_p.H76L	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	76					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GTAACTCAACACAGAACTGAT	0.468													63	162	---	---	---	---	PASS
STAMBP	10617	broad.mit.edu	37	2	74089375	74089375	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74089375G>A	uc002sjs.2	+	10	1314	c.1264G>A	c.(1264-1266)GAC>AAC	p.D422N	STAMBP_uc002sjt.2_Missense_Mutation_p.D422N|STAMBP_uc002sju.2_Missense_Mutation_p.D422N|STAMBP_uc002sjv.2_Missense_Mutation_p.D422N	NM_201647	NP_964010	O95630	STABP_HUMAN	STAM binding protein	422					JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			ovary(1)|lung(1)|breast(1)|pancreas(1)	4						GACCATCACAGACCTTCGATG	0.423													30	81	---	---	---	---	PASS
SLC4A5	57835	broad.mit.edu	37	2	74460582	74460582	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74460582T>C	uc002sko.1	-	18	2544	c.2542A>G	c.(2542-2544)ATG>GTG	p.M848V	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.M848V|SLC4A5_uc010ffc.1_Missense_Mutation_p.M848V|SLC4A5_uc002skp.1_Missense_Mutation_p.M746V|SLC4A5_uc002sks.1_Missense_Mutation_p.M810V	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	848	Helical; (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						TGCTGGTCCATGAAGATCAGG	0.567													24	52	---	---	---	---	PASS
REG3G	130120	broad.mit.edu	37	2	79255402	79255402	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:79255402G>A	uc002snw.2	+	6	613	c.528G>A	c.(526-528)TAG>TAA	p.*176*	REG3G_uc002snx.2_Silent_p.*176*|REG3G_uc010ffu.2_Silent_p.*130*	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	176					acute-phase response	extracellular region	sugar binding				0						TCAAGGACTAGGGCAGGTGGG	0.478													28	88	---	---	---	---	PASS
REG1A	5967	broad.mit.edu	37	2	79350055	79350055	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:79350055G>T	uc002snz.2	+	5	513	c.410G>T	c.(409-411)TGT>TTT	p.C137F	REG1A_uc010ysd.1_Missense_Mutation_p.C137F	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	137	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CCTGGCTACTGTGTGAGCCTG	0.567													40	109	---	---	---	---	PASS
CTNNA2	1496	broad.mit.edu	37	2	80085257	80085257	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:80085257C>G	uc010ysh.1	+	3	422	c.417C>G	c.(415-417)ATC>ATG	p.I139M	CTNNA2_uc010yse.1_Missense_Mutation_p.I139M|CTNNA2_uc010ysf.1_Missense_Mutation_p.I139M|CTNNA2_uc010ysg.1_Missense_Mutation_p.I139M	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	139					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GCTTACTCATCCTGGCGGACA	0.502													63	77	---	---	---	---	PASS
RANBP2	5903	broad.mit.edu	37	2	109378557	109378557	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109378557T>G	uc002tem.3	+	19	2729	c.2603T>G	c.(2602-2604)GTT>GGT	p.V868G		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	868					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						GTTTTTTTAGTTGCAACTACT	0.338													69	127	---	---	---	---	PASS
MERTK	10461	broad.mit.edu	37	2	112754908	112754908	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112754908G>T	uc002thk.1	+	10	1581	c.1459G>T	c.(1459-1461)GAT>TAT	p.D487Y	MERTK_uc002thl.1_Missense_Mutation_p.D311Y	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	487	Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						AGGTTGGGTAGATTATGCCCC	0.428													107	306	---	---	---	---	PASS
DPP10	57628	broad.mit.edu	37	2	116538458	116538458	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:116538458C>A	uc002tla.1	+	16	1827	c.1370C>A	c.(1369-1371)ACT>AAT	p.T457N	DPP10_uc002tlb.1_Missense_Mutation_p.T407N|DPP10_uc002tlc.1_Missense_Mutation_p.T453N|DPP10_uc002tle.2_Missense_Mutation_p.T461N|DPP10_uc002tlf.1_Missense_Mutation_p.T450N	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	457	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AGTGCTTCTACTGAAGGATTA	0.308													49	150	---	---	---	---	PASS
CNTNAP5	129684	broad.mit.edu	37	2	125405389	125405389	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:125405389G>A	uc002tno.2	+	13	2292	c.1928G>A	c.(1927-1929)CGG>CAG	p.R643Q	CNTNAP5_uc010flu.2_Missense_Mutation_p.R644Q	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	643	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		ACCCGAGTGCGGGGCGCTAAC	0.562													3	42	---	---	---	---	PASS
WDR33	55339	broad.mit.edu	37	2	128477651	128477651	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128477651G>T	uc002tpg.1	-	16	2131	c.1948C>A	c.(1948-1950)CAA>AAA	p.Q650K		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	650	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		ATGAATCCTTGTGGCCCCCCA	0.652													21	77	---	---	---	---	PASS
FAM128A	653784	broad.mit.edu	37	2	132241747	132241747	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132241747C>A	uc002tsw.3	-	3	479	c.364G>T	c.(364-366)GCG>TCG	p.A122S	FAM128A_uc002tsv.3_RNA	NM_001085365	NP_001078834	Q6P582	MZT2A_HUMAN	hypothetical protein LOC653784	122						centrosome|gamma-tubulin ring complex|spindle					0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTGCGTTCCGCCAGGGCCAAT	0.632													76	87	---	---	---	---	PASS
NCKAP5	344148	broad.mit.edu	37	2	133489393	133489393	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:133489393A>G	uc002ttp.2	-	17	5734	c.5360T>C	c.(5359-5361)ATT>ACT	p.I1787T	NCKAP5_uc002ttq.2_Missense_Mutation_p.I468T	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1787							protein binding				0						GGAATGAACAATGGCGCTATC	0.562													27	111	---	---	---	---	PASS
TMEM163	81615	broad.mit.edu	37	2	135470778	135470778	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:135470778G>A	uc002ttx.2	-	2	380	c.314C>T	c.(313-315)GCT>GTT	p.A105V	TMEM163_uc002tty.2_RNA	NM_030923	NP_112185	Q8TC26	TM163_HUMAN	transmembrane protein 163	105	Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(221;0.154)		ACTAAAGGCAGCCACCGCGAG	0.522													60	111	---	---	---	---	PASS
R3HDM1	23518	broad.mit.edu	37	2	136399333	136399333	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136399333G>T	uc002tuo.2	+	15	1817	c.1447G>T	c.(1447-1449)GGC>TGC	p.G483C	R3HDM1_uc010fni.2_Missense_Mutation_p.G481C|R3HDM1_uc002tup.2_Missense_Mutation_p.G427C|R3HDM1_uc010zbh.1_Intron	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	483							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		CATACCACCTGGCAGTATTCT	0.408													38	91	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141771157	141771157	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141771157C>A	uc002tvj.1	-	14	3320	c.2348G>T	c.(2347-2349)GGG>GTG	p.G783V	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	783	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATCTGAAGCCCAAATAGGGG	0.333										TSP Lung(27;0.18)			45	133	---	---	---	---	PASS
ZEB2	9839	broad.mit.edu	37	2	145156420	145156420	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:145156420G>A	uc002tvu.2	-	8	2814	c.2334C>T	c.(2332-2334)TCC>TCT	p.S778S	ZEB2_uc002tvv.2_Silent_p.S772S|ZEB2_uc010zbm.1_Silent_p.S749S|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Silent_p.S807S	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	778						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TATTACTCCTGGAGTGGTCCA	0.418													107	244	---	---	---	---	PASS
SLC4A10	57282	broad.mit.edu	37	2	162661104	162661104	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162661104T>C	uc002ubx.3	+	3	460	c.276T>C	c.(274-276)TTT>TTC	p.F92F	SLC4A10_uc010fpa.1_Silent_p.F104F|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Silent_p.F92F|SLC4A10_uc010zcs.1_Silent_p.F103F	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	92	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CACCTTCTTTTGGTAAGAATC	0.343													12	42	---	---	---	---	PASS
DPP4	1803	broad.mit.edu	37	2	162851843	162851843	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162851843C>A	uc002ubz.2	-	24	2653	c.2092G>T	c.(2092-2094)GTT>TTT	p.V698F	DPP4_uc010fpb.2_Missense_Mutation_p.V374F	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	698	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	AGGTACTCAACTTGTTTAAAA	0.343													77	110	---	---	---	---	PASS
HOXD4	3233	broad.mit.edu	37	2	177016524	177016524	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:177016524C>A	uc002uks.2	+	1	412	c.163C>A	c.(163-165)CCC>ACC	p.P55T		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	55						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		CTACCCACGGCCCGACTTCGG	0.741													11	26	---	---	---	---	PASS
TTC30A	92104	broad.mit.edu	37	2	178481726	178481726	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178481726G>A	uc002ulo.2	-	1	1969	c.1704C>T	c.(1702-1704)ATC>ATT	p.I568I		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	568	TPR 8.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CCAAGCTTTTGATAACTCGAG	0.373													9	501	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179497445	179497445	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179497445C>A	uc010zfg.1	-	184	35808	c.35584G>T	c.(35584-35586)GAA>TAA	p.E11862*	TTN_uc010zfh.1_Nonsense_Mutation_p.E5557*|TTN_uc010zfi.1_Nonsense_Mutation_p.E5490*|TTN_uc010zfj.1_Nonsense_Mutation_p.E5365*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12789							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGATACTTCACACTCAAAC	0.428													5	359	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179550314	179550314	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179550314G>A	uc010zfg.1	-	125	28815	c.28591C>T	c.(28591-28593)CCT>TCT	p.P9531S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6192S|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10458							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTCCTCAGGCTCTTCCATC	0.333													4	47	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179587057	179587057	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179587057G>C	uc010zfg.1	-	74	18949	c.18725C>G	c.(18724-18726)TCT>TGT	p.S6242C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S2903C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7169							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTACTGGCCAGAGTGACTCAA	0.398													15	61	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179590306	179590306	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179590306T>C	uc010zfg.1	-	68	17117	c.16893A>G	c.(16891-16893)GCA>GCG	p.A5631A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.A2292A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6558							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTATGGATGCTTGTAATT	0.423													26	88	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179610664	179610664	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179610664C>T	uc002unb.2	-	46	16687	c.16463G>A	c.(16462-16464)AGC>AAC	p.S5488N	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTAAACTGCTTAAAGTCAC	0.408													63	210	---	---	---	---	PASS
CCDC141	285025	broad.mit.edu	37	2	179734015	179734015	+	Silent	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179734015A>T	uc002unf.1	-	5	555	c.498T>A	c.(496-498)GTT>GTA	p.V166V		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	166							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TAATGTACTGAACCTCATCAT	0.323													25	93	---	---	---	---	PASS
FRZB	2487	broad.mit.edu	37	2	183731163	183731163	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183731163T>A	uc002upa.1	-	1	336	c.118A>T	c.(118-120)ATC>TTC	p.I40F		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	40	FZ.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			CACAGGGGGATGCGGACGGGC	0.677													28	15	---	---	---	---	PASS
COL3A1	1281	broad.mit.edu	37	2	189868702	189868702	+	Intron	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189868702T>G	uc002uqj.1	+							NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein						axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AAACAATTATTTGTAGGGTAA	0.413													10	16	---	---	---	---	PASS
COL5A2	1290	broad.mit.edu	37	2	189953453	189953453	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189953453C>T	uc002uqk.2	-	8	888	c.613G>A	c.(613-615)GGG>AGG	p.G205R	COL5A2_uc010frx.2_5'Flank	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	205					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ACTTGACTCCCAAGTCCAGAT	0.358													40	67	---	---	---	---	PASS
STAT1	6772	broad.mit.edu	37	2	191848427	191848427	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191848427G>C	uc002usj.2	-	17	1775	c.1387C>G	c.(1387-1389)CAG>GAG	p.Q463E	STAT1_uc010fse.1_Missense_Mutation_p.Q463E|STAT1_uc002usk.2_Missense_Mutation_p.Q463E|STAT1_uc002usl.2_Missense_Mutation_p.Q465E|STAT1_uc010fsf.1_Missense_Mutation_p.Q275E	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	463					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	CTCGGGAGCTGGCTGACGTTG	0.502													5	85	---	---	---	---	PASS
IHH	3549	broad.mit.edu	37	2	219920115	219920115	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219920115G>A	uc002vjo.1	-	3	1050	c.1050C>T	c.(1048-1050)GCC>GCT	p.A350A		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	350					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTCAGCCACGGCCGCGAAGC	0.642													13	13	---	---	---	---	PASS
SPHKAP	80309	broad.mit.edu	37	2	228881146	228881146	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228881146G>A	uc002vpq.2	-	7	4471	c.4424C>T	c.(4423-4425)GCC>GTC	p.A1475V	SPHKAP_uc002vpp.2_Missense_Mutation_p.A1475V|SPHKAP_uc010zlx.1_Missense_Mutation_p.A1475V	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1475						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AGCGCTCACGGCTGTGTCTCC	0.468													75	101	---	---	---	---	PASS
SPHKAP	80309	broad.mit.edu	37	2	228881548	228881548	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228881548G>C	uc002vpq.2	-	7	4069	c.4022C>G	c.(4021-4023)CCC>CGC	p.P1341R	SPHKAP_uc002vpp.2_Missense_Mutation_p.P1341R|SPHKAP_uc010zlx.1_Missense_Mutation_p.P1341R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1341						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGCTTGCGAGGGAGAGCCACC	0.522													23	28	---	---	---	---	PASS
LRRFIP1	9208	broad.mit.edu	37	2	238672186	238672186	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238672186G>A	uc002vxe.2	+	11	2122	c.1830G>A	c.(1828-1830)CAG>CAA	p.Q610Q	LRRFIP1_uc002vxc.2_Intron|LRRFIP1_uc010znm.1_Intron|LRRFIP1_uc002vxd.2_Silent_p.Q586Q|LRRFIP1_uc002vxf.2_Silent_p.Q554Q	NM_001137552	NP_001131024	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting	610					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			breast(3)	3		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		AAGAAGAGCAGGTAAAGTCTA	0.363													21	9	---	---	---	---	PASS
TRAF3IP1	26146	broad.mit.edu	37	2	239261531	239261531	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239261531G>A	uc002vye.2	+	13	1634	c.1515G>A	c.(1513-1515)GAG>GAA	p.E505E	TRAF3IP1_uc002vyf.2_Silent_p.E439E	NM_015650	NP_056465	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting	505	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			ovary(1)	1		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		ACAATGAAGAGGATGATCAAT	0.328													26	62	---	---	---	---	PASS
MYEOV2	150678	broad.mit.edu	37	2	241066112	241066112	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241066112C>A	uc002vyu.1	-	5	627	c.627G>T	c.(625-627)GAG>GAT	p.E209D		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		CTTCGCTGACCTCTCGCCTGC	0.468													98	58	---	---	---	---	PASS
EDEM1	9695	broad.mit.edu	37	3	5246937	5246937	+	Intron	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:5246937C>T	uc003bqi.2	+						EDEM1_uc011asz.1_Intron|EDEM1_uc003bqh.2_Intron	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like						ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		GTATGTCTCCCTAACATCTCC	0.368													27	36	---	---	---	---	PASS
SETD5	55209	broad.mit.edu	37	3	9482323	9482323	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9482323G>A	uc003brt.2	+	8	1186	c.751G>A	c.(751-753)GAC>AAC	p.D251N	SETD5_uc003brs.1_Missense_Mutation_p.D232N|SETD5_uc003bru.2_Missense_Mutation_p.D153N|SETD5_uc003brv.2_Missense_Mutation_p.D140N|SETD5_uc010hck.2_5'Flank|SETD5_uc003brw.1_5'Flank|SETD5_uc003brx.2_5'Flank	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	251										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		TACTATTTTAGACACTATTAA	0.398													24	22	---	---	---	---	PASS
GRIP2	80852	broad.mit.edu	37	3	14581778	14581778	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14581778G>T	uc011avi.1	-	2	329	c.329C>A	c.(328-330)GCG>GAG	p.A110E	GRIP2_uc011avh.1_5'UTR|GRIP2_uc003byv.1_Missense_Mutation_p.A13E	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	13					synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						TTACGTACCCGCCTCTCCAGG	0.637													10	9	---	---	---	---	PASS
RBMS3	27303	broad.mit.edu	37	3	30045356	30045356	+	3'UTR	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:30045356A>C	uc003cel.2	+	15					RBMS3_uc003cem.2_3'UTR|RBMS3_uc010hfr.2_3'UTR	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting							cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				GACCATAAACAGGACTGAAGA	0.368													26	62	---	---	---	---	PASS
SCN11A	11280	broad.mit.edu	37	3	38889189	38889189	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38889189G>A	uc011ays.1	-	26	4571	c.4372C>T	c.(4372-4374)CCT>TCT	p.P1458S		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1458	IV.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AGCGTCGGAGGGAAAGGAATG	0.493													21	25	---	---	---	---	PASS
ZNF35	7584	broad.mit.edu	37	3	44700479	44700479	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44700479C>T	uc003cnq.2	+	4	845	c.624C>T	c.(622-624)GGC>GGT	p.G208G	ZNF35_uc003cnr.2_Silent_p.G48G	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	208	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		TTAATTCTGGCGCTGTTAAAA	0.413													4	117	---	---	---	---	PASS
LTF	4057	broad.mit.edu	37	3	46480790	46480790	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46480790T>C	uc003cpq.2	-	15	1943	c.1905A>G	c.(1903-1905)CAA>CAG	p.Q635Q	LTF_uc003fzr.2_Silent_p.Q591Q|LTF_uc010hjh.2_Silent_p.Q633Q|LTF_uc003cpr.2_Silent_p.Q622Q	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	635	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TCCATACCTGTTGGTGGAGCA	0.547													39	57	---	---	---	---	PASS
DNAH1	25981	broad.mit.edu	37	3	52417486	52417486	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52417486G>T	uc011bef.1	+	51	8287	c.8026G>T	c.(8026-8028)GAC>TAC	p.D2676Y	DNAH1_uc003ddv.2_5'Flank	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2676	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGACGAGCAGGACCAGATCGT	0.552													10	9	---	---	---	---	PASS
FLNB	2317	broad.mit.edu	37	3	58156459	58156459	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58156459T>C	uc003djj.2	+	46	7944	c.7779T>C	c.(7777-7779)CCT>CCC	p.P2593P	FLNB_uc010hne.2_Silent_p.P2624P|FLNB_uc003djk.2_Silent_p.P2582P|FLNB_uc010hnf.2_Silent_p.P2569P|FLNB_uc003djl.2_Silent_p.P2413P|FLNB_uc003djm.2_Silent_p.P2400P|uc003djn.2_5'Flank	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2593	Interaction with INPPL1.|Filamin 24.|Self-association site, tail (By similarity).|Interaction with FLNA 2.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		AACACATCCCTGGCAGCCCTT	0.458													22	32	---	---	---	---	PASS
ATG3	64422	broad.mit.edu	37	3	112267449	112267449	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112267449C>T	uc003dzd.2	-	5	384	c.274G>A	c.(274-276)GAT>AAT	p.D92N	ATG3_uc003dzc.2_Missense_Mutation_p.D92N|ATG3_uc010hqe.2_Missense_Mutation_p.D92N	NM_022488	NP_071933	Q9NT62	ATG3_HUMAN	Apg3p	92					autophagic vacuole assembly|mitochondrial fragmentation involved in apoptosis|protein targeting to membrane|protein ubiquitination	cytoplasmic ubiquitin ligase complex|cytosol	Atg12 ligase activity|Atg8 ligase activity|enzyme binding			ovary(3)	3						TCCAATTCATCTGAATATTCC	0.358													80	137	---	---	---	---	PASS
IGSF11	152404	broad.mit.edu	37	3	118753386	118753386	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:118753386G>A	uc003ebw.2	-	1	291	c.44C>T	c.(43-45)TCT>TTT	p.S15F	IGSF11_uc011biv.1_Missense_Mutation_p.S15F|IGSF11_uc003ebx.2_Missense_Mutation_p.S15F|IGSF11_uc003eby.2_Intron|IGSF11_uc003ebz.2_Intron|IGSF11_uc010hqs.2_Intron	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	15					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						ACCGTGCAGAGAGAGGAGCAG	0.692													5	10	---	---	---	---	PASS
C3orf30	152405	broad.mit.edu	37	3	118870083	118870083	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:118870083A>T	uc003ecb.1	+	3	1595	c.1555A>T	c.(1555-1557)AAC>TAC	p.N519Y	C3orf30_uc011biw.1_Missense_Mutation_p.N518Y	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	519										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		GATTACTGAAAACTTAGTCTA	0.348													93	571	---	---	---	---	PASS
GPR156	165829	broad.mit.edu	37	3	119900054	119900054	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119900054C>T	uc011bjf.1	-	7	851	c.851G>A	c.(850-852)TGG>TAG	p.W284*	GPR156_uc011bjg.1_Nonsense_Mutation_p.W280*	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	284	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		CAGGTTGGGCCAGGAATGCAA	0.493													48	104	---	---	---	---	PASS
POLQ	10721	broad.mit.edu	37	3	121200428	121200428	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121200428T>C	uc003eee.3	-	19	6331	c.6202A>G	c.(6202-6204)AAC>GAC	p.N2068D	POLQ_uc003eed.2_Missense_Mutation_p.N1240D	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2068					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CCTTGAAGGTTTTCCTTCTGC	0.368								DNA_polymerases_(catalytic_subunits)					53	116	---	---	---	---	PASS
CASR	846	broad.mit.edu	37	3	121980393	121980393	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121980393A>G	uc003eev.3	+	4	883	c.511A>G	c.(511-513)AGC>GGC	p.S171G	CASR_uc003eew.3_Missense_Mutation_p.S171G	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	171	Extracellular (Potential).		S -> N (could be associated with FHH).		anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGCCTCCTCCAGCAGACTCCT	0.453													24	292	---	---	---	---	PASS
DIRC2	84925	broad.mit.edu	37	3	122545685	122545685	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122545685G>T	uc003efw.3	+	3	615	c.476G>T	c.(475-477)GGT>GTT	p.G159V	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_5'UTR	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	159	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		GGATTGGCAGGTCCAACTGTA	0.393													18	141	---	---	---	---	PASS
SLC12A8	84561	broad.mit.edu	37	3	124802767	124802767	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124802767G>A	uc003ehv.3	-	14	2223	c.2112C>T	c.(2110-2112)CTC>CTT	p.L704L	SLC12A8_uc003ehw.3_Silent_p.L733L|SLC12A8_uc003eht.3_Silent_p.L505L|SLC12A8_uc003ehu.3_Silent_p.L457L|SLC12A8_uc010hry.2_3'UTR	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	704					potassium ion transport	integral to membrane	symporter activity				0						CCCGGTTCACGAGGGAGGAGT	0.577													10	46	---	---	---	---	PASS
ZNF148	7707	broad.mit.edu	37	3	124952367	124952367	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124952367C>A	uc003ehx.3	-	9	1689	c.1203G>T	c.(1201-1203)CTG>CTT	p.L401L	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Silent_p.L401L|ZNF148_uc010hsa.2_Silent_p.L401L|ZNF148_uc003eia.3_Silent_p.L401L|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	401					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						GTGGCTGTTTCAGACTTCTCT	0.388													25	57	---	---	---	---	PASS
ALDH1L1	10840	broad.mit.edu	37	3	125822661	125822661	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:125822661C>A	uc003eim.1	-	23	2872	c.2682G>T	c.(2680-2682)CGG>CGT	p.R894R	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.R793R|SLC41A3_uc011bkh.1_5'Flank	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	894	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CTGTCTTGACCCGCAGGTACT	0.577													10	34	---	---	---	---	PASS
COL29A1	256076	broad.mit.edu	37	3	130159169	130159169	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130159169C>T	uc010htj.1	+	35	6481	c.5987C>T	c.(5986-5988)GCT>GTT	p.A1996V	COL29A1_uc010hti.1_RNA|COL29A1_uc010htk.1_Missense_Mutation_p.A35V	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	1996	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen					0						TTCAACATTGCTTCAGACCCT	0.418													24	64	---	---	---	---	PASS
COL6A6	131873	broad.mit.edu	37	3	130290100	130290100	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130290100G>T	uc010htl.2	+	6	2871	c.2840G>T	c.(2839-2841)GGG>GTG	p.G947V		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	947	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CTGGCTGTGGGGATTGATGGT	0.507													45	66	---	---	---	---	PASS
CPNE4	131034	broad.mit.edu	37	3	131300447	131300447	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:131300447G>T	uc003eok.2	-	9	1278	c.843C>A	c.(841-843)GGC>GGA	p.G281G	CPNE4_uc011blq.1_Silent_p.G299G|CPNE4_uc003eol.2_Silent_p.G299G|CPNE4_uc003eom.2_Silent_p.G281G	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	281										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GAATCACAGTGCCTGAGTTCT	0.463													47	111	---	---	---	---	PASS
NPHP3	27031	broad.mit.edu	37	3	132418302	132418302	+	Intron	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132418302A>T	uc003epe.1	-						NPHP3_uc003epd.1_Intron	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3						maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						TTGCTTAAAAATATAAAAACA	0.289													36	53	---	---	---	---	PASS
ATR	545	broad.mit.edu	37	3	142185204	142185204	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142185204G>T	uc003eux.3	-	40	6981	c.6859C>A	c.(6859-6861)CCT>ACT	p.P2287T	ATR_uc003euy.1_Missense_Mutation_p.P173T	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2287					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CAATGTCCAGGAAATGGTTCA	0.348								Other_conserved_DNA_damage_response_genes					55	161	---	---	---	---	PASS
PAQR9	344838	broad.mit.edu	37	3	142681874	142681874	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142681874C>T	uc003evg.2	-	1	305	c.305G>A	c.(304-306)TGC>TAC	p.C102Y	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	102	Helical; (Potential).					integral to membrane	receptor activity				0						GAACAGACGGCAGAACTTGCT	0.627													21	38	---	---	---	---	PASS
SLC9A9	285195	broad.mit.edu	37	3	143412060	143412060	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:143412060C>G	uc003evn.2	-	5	805	c.623G>C	c.(622-624)GGT>GCT	p.G208A	SLC9A9_uc011bnk.1_Missense_Mutation_p.G82A	NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	208	Helical; (Potential).				regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						CATCAGTGAACCAAAAAATAA	0.338													12	122	---	---	---	---	PASS
PLSCR2	57047	broad.mit.edu	37	3	146173210	146173210	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:146173210A>G	uc003evv.1	-	5	470	c.137T>C	c.(136-138)ATC>ACC	p.I46T	PLSCR2_uc003evw.1_Missense_Mutation_p.I115T	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	46	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						GCTGTTCTTGATTTCATACAT	0.328													30	278	---	---	---	---	PASS
CPA3	1359	broad.mit.edu	37	3	148583320	148583320	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148583320G>T	uc003ewm.2	+	2	181	c.129G>T	c.(127-129)TTG>TTT	p.L43F		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	43					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TAAAGGACTTGGCCAAAACCA	0.393													60	51	---	---	---	---	PASS
WWTR1	25937	broad.mit.edu	37	3	149260288	149260288	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:149260288C>A	uc003exe.2	-	3	621	c.605G>T	c.(604-606)AGT>ATT	p.S202I	WWTR1_uc003exf.2_Missense_Mutation_p.S202I|WWTR1_uc011bns.1_Missense_Mutation_p.S202I|WWTR1_uc003exh.2_Missense_Mutation_p.S202I	NM_015472	NP_056287	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	202	Gln-rich.				hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCTCAGGGTACTGGGGGCCAT	0.537													23	192	---	---	---	---	PASS
MED12L	116931	broad.mit.edu	37	3	150883274	150883274	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150883274G>T	uc003eyp.2	+	9	1363	c.1325G>T	c.(1324-1326)TGG>TTG	p.W442L	MED12L_uc011bnz.1_Missense_Mutation_p.W302L|MED12L_uc003eyn.2_Missense_Mutation_p.W442L|MED12L_uc003eyo.2_Missense_Mutation_p.W442L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	442					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GAAGTTCGGTGGTCATTTGAC	0.418													40	48	---	---	---	---	PASS
IGSF10	285313	broad.mit.edu	37	3	151166180	151166180	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151166180A>G	uc011bod.1	-	4	1589	c.1589T>C	c.(1588-1590)ATA>ACA	p.I530T		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	530	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACTTTTGTCTATTAGGATCCG	0.468													190	238	---	---	---	---	PASS
AADAC	13	broad.mit.edu	37	3	151538218	151538218	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151538218G>A	uc003eze.2	+	3	499	c.409G>A	c.(409-411)GAT>AAT	p.D137N		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	137	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AGACAGACTTGATGCTGTCGT	0.373													48	125	---	---	---	---	PASS
GFM1	85476	broad.mit.edu	37	3	158366843	158366843	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158366843C>A	uc003fce.2	+	5	693	c.586C>A	c.(586-588)CAT>AAT	p.H196N	GFM1_uc003fcd.2_Missense_Mutation_p.H196N|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Missense_Mutation_p.H108N	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	196					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TAAACTAAATCATAATGCAGC	0.323													11	603	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	3	161147009	161147009	+	IGR	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:161147009A>G								C3orf57 (57138 upstream) : OTOL1 (67587 downstream)																							CCGAATCAGGATGTTGACCTT	0.438													5	295	---	---	---	---	PASS
SLITRK3	22865	broad.mit.edu	37	3	164906771	164906771	+	Missense_Mutation	SNP	G	T	T	rs35378268		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:164906771G>T	uc003fej.3	-	2	2292	c.1848C>A	c.(1846-1848)CAC>CAA	p.H616Q	SLITRK3_uc003fek.2_Missense_Mutation_p.H616Q	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	616	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CTGGTGCAACGTGCAGCATCT	0.557										HNSCC(40;0.11)			44	37	---	---	---	---	PASS
ZBBX	79740	broad.mit.edu	37	3	167031866	167031866	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167031866T>A	uc003fep.2	-	16	1636	c.1313A>T	c.(1312-1314)TAT>TTT	p.Y438F	ZBBX_uc011bpc.1_Missense_Mutation_p.Y438F|ZBBX_uc003feq.2_Missense_Mutation_p.Y409F	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	438						intracellular	zinc ion binding			ovary(2)	2						GCCATTTTCATATGGAAAGCT	0.289													194	162	---	---	---	---	PASS
WDR49	151790	broad.mit.edu	37	3	167245807	167245807	+	Splice_Site	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167245807T>C	uc003fev.1	-	11	1657	c.1351_splice	c.e11-1	p.E451_splice	WDR49_uc003feu.1_Splice_Site_p.E276_splice|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49											large_intestine(1)|ovary(1)|skin(1)	3						ACAGTACTCCTGAATGAAAAG	0.348													61	165	---	---	---	---	PASS
PRKCI	5584	broad.mit.edu	37	3	169998110	169998110	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169998110A>T	uc003fgs.2	+	9	1039	c.801A>T	c.(799-801)AAA>AAT	p.K267N		NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	267	ATP (By similarity).|Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GTTATGCCAAAGTACTGTTGG	0.378													156	112	---	---	---	---	PASS
ECT2	1894	broad.mit.edu	37	3	172482145	172482145	+	Silent	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172482145T>G	uc003fii.2	+	11	1191	c.1053T>G	c.(1051-1053)CGT>CGG	p.R351R	ECT2_uc010hwv.1_Silent_p.R382R|ECT2_uc003fih.2_Silent_p.R350R|ECT2_uc003fij.1_Silent_p.R351R|ECT2_uc003fik.1_Silent_p.R351R|ECT2_uc003fil.1_Silent_p.R382R	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	351					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AACGACGTCGTTTAAAAGAAA	0.458													17	240	---	---	---	---	PASS
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			83	156	---	---	---	---	PASS
SOX2	6657	broad.mit.edu	37	3	181430281	181430281	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:181430281A>T	uc003fkx.2	+	1	560	c.133A>T	c.(133-135)ATG>TTG	p.M45L	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	45	HMG box.				cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			CAAGCGGCCCATGAATGCCTT	0.701			A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						26	58	---	---	---	---	PASS
MCF2L2	23101	broad.mit.edu	37	3	182947453	182947453	+	Splice_Site	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:182947453C>A	uc003fli.1	-	17	2135	c.2045_splice	c.e17+1	p.R682_splice	MCF2L2_uc003flj.1_Splice_Site_p.R682_splice	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TTATTATATACCTGTTGTGAA	0.333													190	171	---	---	---	---	PASS
MAP3K13	9175	broad.mit.edu	37	3	185184731	185184731	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185184731A>G	uc010hyf.2	+	11	1889	c.1623A>G	c.(1621-1623)AAA>AAG	p.K541K	MAP3K13_uc011brt.1_Silent_p.K334K|MAP3K13_uc011bru.1_Silent_p.K397K|MAP3K13_uc003fpi.2_Silent_p.K541K|MAP3K13_uc010hyg.2_Silent_p.K231K	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	541					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGCCTCACAAATCTGGGATGC	0.463													16	174	---	---	---	---	PASS
ATP13A4	84239	broad.mit.edu	37	3	193174803	193174803	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193174803C>A	uc003ftd.2	-	16	2009	c.1901G>T	c.(1900-1902)TGC>TTC	p.C634F	ATP13A4_uc003fte.1_Missense_Mutation_p.C634F|ATP13A4_uc011bsr.1_Missense_Mutation_p.C105F|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	634	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CTCAGGTTGGCAAAAGCTGGC	0.363													41	22	---	---	---	---	PASS
ZNF721	170960	broad.mit.edu	37	4	435662	435662	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:435662T>C	uc003gag.2	-	3	3285	c.2594A>G	c.(2593-2595)TAC>TGC	p.Y865C	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.Y897C|ZNF721_uc010ibe.2_Missense_Mutation_p.Y853C	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	865						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TCCACATGTGTAGGGTTTCTC	0.418													30	61	---	---	---	---	PASS
PDE6B	5158	broad.mit.edu	37	4	658020	658020	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:658020G>T	uc003gap.2	+						PDE6B_uc003gao.3_Intron|PDE6B_uc011buy.1_Intron|PDE6B_uc011buz.1_Intron	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1						cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						TGTGAGCGCGGGCGGAGGGGG	0.632													10	35	---	---	---	---	PASS
EVC2	132884	broad.mit.edu	37	4	5570322	5570322	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5570322C>G	uc003gij.2	-	20	3460	c.3406G>C	c.(3406-3408)GGG>CGG	p.G1136R	EVC2_uc011bwb.1_Missense_Mutation_p.G576R|EVC2_uc003gik.2_Missense_Mutation_p.G1056R	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1136						integral to membrane				large_intestine(3)|ovary(2)	5						AGCGTGGCCCCGGGCACCATG	0.622													6	24	---	---	---	---	PASS
SLIT2	9353	broad.mit.edu	37	4	20525428	20525428	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20525428T>C	uc003gpr.1	+	13	1380	c.1176T>C	c.(1174-1176)TTT>TTC	p.F392F	SLIT2_uc003gps.1_Silent_p.F392F	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	392	LRR 10.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TAGATGCTTTTCAGGATCTCC	0.408													60	138	---	---	---	---	PASS
PCDH7	5099	broad.mit.edu	37	4	30724425	30724425	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:30724425A>C	uc003gsk.1	+	1	2389	c.1381A>C	c.(1381-1383)ACC>CCC	p.T461P	PCDH7_uc011bxw.1_Missense_Mutation_p.T414P|PCDH7_uc011bxx.1_Missense_Mutation_p.T461P	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	461	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GGTCACCTGCACCGTGGTGGG	0.642													12	29	---	---	---	---	PASS
UGDH	7358	broad.mit.edu	37	4	39523086	39523086	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39523086C>A	uc003guk.1	-	2	363	c.47G>T	c.(46-48)GGA>GTA	p.G16V	UGDH_uc011byp.1_Intron|UGDH_uc003gul.1_Missense_Mutation_p.G16V	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	16	NAD.				glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TGTGGGTCCTCCAACATAGCC	0.383													4	157	---	---	---	---	PASS
BEND4	389206	broad.mit.edu	37	4	42119660	42119660	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42119660C>G	uc003gwn.2	-	6	2060	c.1480G>C	c.(1480-1482)GCC>CCC	p.A494P	BEND4_uc003gwm.2_3'UTR	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	494	BEN.										0						CCCTGTCGGGCGTGACCGACA	0.527													5	11	---	---	---	---	PASS
ATP8A1	10396	broad.mit.edu	37	4	42446601	42446601	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42446601C>T	uc003gwr.2	-	32	3241	c.3009G>A	c.(3007-3009)TGG>TGA	p.W1003*	ATP8A1_uc003gwq.2_Nonsense_Mutation_p.W229*|ATP8A1_uc003gws.2_Nonsense_Mutation_p.W988*	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	1003	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TTACCCATGTCCAATATGATG	0.363													15	50	---	---	---	---	PASS
ATP8A1	10396	broad.mit.edu	37	4	42592907	42592907	+	Intron	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42592907C>A	uc003gwr.2	-						ATP8A1_uc003gws.2_Intron|ATP8A1_uc011byz.1_Intron	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),						ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	GCCACCTACACGTCCCAGTAT	0.378													29	90	---	---	---	---	PASS
GRXCR1	389207	broad.mit.edu	37	4	42895516	42895516	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42895516A>G	uc003gwt.2	+	1	233	c.233A>G	c.(232-234)GAT>GGT	p.D78G		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	78					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						AATGACCAGGATAGCTTGCTG	0.463													38	83	---	---	---	---	PASS
GABRG1	2565	broad.mit.edu	37	4	46099206	46099206	+	Intron	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:46099206A>T	uc003gxb.2	-							NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1						gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CAGAATGGTAACTCAAGCTTA	0.348													49	105	---	---	---	---	PASS
KDR	3791	broad.mit.edu	37	4	55979624	55979624	+	Nonsense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:55979624G>A	uc003has.2	-	7	1125	c.823C>T	c.(823-825)CGA>TGA	p.R275*	KDR_uc003hat.1_Nonsense_Mutation_p.R275*|KDR_uc011bzx.1_Nonsense_Mutation_p.R275*	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	275	Ig-like C2-type 3.|Extracellular (Potential).		R -> L (in a colorectal cancer sample; somatic mutation).		angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.R275L(1)		lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTTAGGTCTCGGTTTACAAGT	0.398			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			26	77	---	---	---	---	PASS
LPHN3	23284	broad.mit.edu	37	4	62800567	62800567	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:62800567G>C	uc010ihh.2	+	11	2091	c.1918G>C	c.(1918-1920)GAG>CAG	p.E640Q	LPHN3_uc003hcq.3_Missense_Mutation_p.E640Q|LPHN3_uc003hct.2_Missense_Mutation_p.E33Q|LPHN3_uc003hcs.1_Missense_Mutation_p.E456Q	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	627	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GGCAATGGTCGAGACAGTTAA	0.488													10	31	---	---	---	---	PASS
EPHA5	2044	broad.mit.edu	37	4	66217280	66217280	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:66217280C>A	uc003hcy.2	-	14	2528	c.2335G>T	c.(2335-2337)GGC>TGC	p.G779C	EPHA5_uc003hcx.2_Missense_Mutation_p.G711C|EPHA5_uc003hcz.2_Missense_Mutation_p.G757C|EPHA5_uc011cah.1_Missense_Mutation_p.G780C|EPHA5_uc011cai.1_Missense_Mutation_p.G758C|EPHA5_uc003hda.2_Missense_Mutation_p.G780C	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	779	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CTCAGCATGCCAACAAGCTGA	0.418										TSP Lung(17;0.13)			22	57	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	4	69334596	69334596	+	Splice_Site	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69334596G>A	uc003hdz.3	+	4	323	c.259_splice	c.e4-1	p.V87_splice		NM_014058	NP_054777			transmembrane protease, serine 11E																		TTTACAAACAGGTGAAAAATG	0.279													9	365	---	---	---	---	PASS
HTN3	3347	broad.mit.edu	37	4	70897695	70897695	+	Splice_Site	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70897695G>C	uc003hew.2	+	3	169	c.52_splice	c.e3-1	p.G18_splice		NM_000200	NP_000191	P15516	HIS3_HUMAN	histatin 3						biomineral tissue development|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	metal ion binding|protein binding			ovary(1)|skin(1)	2						TCTTTTCCAAGGGAGCTGATT	0.234													5	153	---	---	---	---	PASS
AMTN	401138	broad.mit.edu	37	4	71389637	71389637	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71389637C>A	uc003hfk.1	+	4	280	c.191C>A	c.(190-192)CCA>CAA	p.P64Q	AMTN_uc010ihy.1_Missense_Mutation_p.P63Q	NM_212557	NP_997722	Q6UX39	AMTN_HUMAN	amelotin precursor	64					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				large_intestine(1)|central_nervous_system(1)	2			Lung(101;0.235)			ACACTGGGGCCAGATCTGCAT	0.398													72	203	---	---	---	---	PASS
NPFFR2	10886	broad.mit.edu	37	4	73012893	73012893	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73012893C>A	uc003hgg.2	+	4	1031	c.933C>A	c.(931-933)GAC>GAA	p.D311E	NPFFR2_uc010iig.1_Missense_Mutation_p.D93E|NPFFR2_uc003hgi.2_Missense_Mutation_p.D212E|NPFFR2_uc003hgh.2_Missense_Mutation_p.D209E|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	311	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GCCGGGAAGACTGGCCAAATC	0.463													66	66	---	---	---	---	PASS
CDKL2	8999	broad.mit.edu	37	4	76523342	76523342	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76523342T>C	uc003hiq.2	-	8	1464	c.939A>G	c.(937-939)TTA>TTG	p.L313L	CDKL2_uc011cbp.1_Silent_p.L313L|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	313					sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ATTTTTTAGATAAAGAAACAT	0.289													81	106	---	---	---	---	PASS
ART3	419	broad.mit.edu	37	4	77003484	77003484	+	Missense_Mutation	SNP	G	A	A	rs142545952	byFrequency	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77003484G>A	uc003hjo.2	+	3	696	c.577G>A	c.(577-579)GCT>ACT	p.A193T	ART3_uc003hji.2_Missense_Mutation_p.A193T|ART3_uc003hjj.2_Missense_Mutation_p.A193T|ART3_uc003hjk.2_Missense_Mutation_p.A193T|ART3_uc010ija.1_Missense_Mutation_p.A193T|ART3_uc003hjn.2_Missense_Mutation_p.A193T|ART3_uc003hjp.2_Intron|ART3_uc010ijb.2_Intron|ART3_uc003hjq.2_Intron|ART3_uc003hjr.2_Missense_Mutation_p.A163T|ART3_uc010ijc.2_Missense_Mutation_p.A163T|ART3_uc010ijd.2_Missense_Mutation_p.A163T	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	193					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CAAACCTCAGGCTGCTAATGA	0.403													22	65	---	---	---	---	PASS
FRAS1	80144	broad.mit.edu	37	4	79166399	79166399	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:79166399C>G	uc003hlb.2	+	4	669	c.229C>G	c.(229-231)CAA>GAA	p.Q77E	FRAS1_uc003hkw.2_Missense_Mutation_p.Q77E|FRAS1_uc003hky.1_5'UTR	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	77	VWFC 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						AGAAGTGCTTCAAATAGCTGC	0.428													5	13	---	---	---	---	PASS
FGF5	2250	broad.mit.edu	37	4	81188121	81188121	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:81188121A>C	uc003hmd.2	+	1	380	c.143A>C	c.(142-144)CAG>CCG	p.Q48P	FGF5_uc003hme.2_Missense_Mutation_p.Q48P	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	48					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						AGCAGCAGACAGAGCAGCAGT	0.627													21	41	---	---	---	---	PASS
HPSE	10855	broad.mit.edu	37	4	84216553	84216553	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:84216553C>T	uc003hoj.3	-	12	1675	c.1576G>A	c.(1576-1578)GCT>ACT	p.A526T	uc003hoi.2_5'Flank|HPSE_uc010ika.2_Missense_Mutation_p.A468T|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.A269T|HPSE_uc011cct.1_Missense_Mutation_p.A452T|HPSE_uc003hok.3_Missense_Mutation_p.A526T	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	526					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	TATGAGAAAGCTGGCAAGCCC	0.388													54	65	---	---	---	---	PASS
CXXC4	80319	broad.mit.edu	37	4	105393508	105393508	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:105393508T>A	uc003hxg.2	-	2	583	c.568A>T	c.(568-570)AGC>TGC	p.S190C	uc003hxf.1_5'Flank|CXXC4_uc010ilo.2_RNA	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	CXXC finger 4	190					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		GCTTCAGCGCTGGGAACAGGT	0.333													61	86	---	---	---	---	PASS
C4orf21	55345	broad.mit.edu	37	4	113540355	113540355	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113540355T>C	uc003iau.2	-	6	1054	c.843A>G	c.(841-843)AAA>AAG	p.K281K	C4orf21_uc003iaw.2_Silent_p.K281K	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		CTTGTGGTTGTTTTTGAGGAA	0.373													87	110	---	---	---	---	PASS
BBS7	55212	broad.mit.edu	37	4	122749310	122749310	+	Silent	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122749310T>G	uc003ied.2	-	18	2179	c.2005A>C	c.(2005-2007)AGA>CGA	p.R669R	BBS7_uc003iee.1_Silent_p.R669R	NM_176824	NP_789794	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7 protein isoform a	669					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1						CCATAGAGTCTTTCAAGATGT	0.393									Bardet-Biedl_syndrome				77	121	---	---	---	---	PASS
SMAD1	4086	broad.mit.edu	37	4	146461124	146461124	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146461124G>C	uc003ikc.2	+	3	985	c.569G>C	c.(568-570)AGC>ACC	p.S190T	SMAD1_uc003ikd.2_Missense_Mutation_p.S190T|SMAD1_uc010iov.2_Missense_Mutation_p.S190T|SMAD1_uc011cic.1_Missense_Mutation_p.S190T|SMAD1_uc003ikf.2_RNA	NM_005900	NP_005891	Q15797	SMAD1_HUMAN	Sma- and Mad-related protein 1	190					BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					TCTCCCAATAGCAGTTACCCA	0.537													17	31	---	---	---	---	PASS
RXFP1	59350	broad.mit.edu	37	4	159547986	159547986	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159547986A>G	uc003ipz.2	+	10	852	c.770A>G	c.(769-771)AAC>AGC	p.N257S	RXFP1_uc010iqj.1_Missense_Mutation_p.N86S|RXFP1_uc011cja.1_Intron|RXFP1_uc010iqo.2_Missense_Mutation_p.N257S|RXFP1_uc011cjb.1_Missense_Mutation_p.N203S|RXFP1_uc010iqk.2_Missense_Mutation_p.N125S|RXFP1_uc011cjc.1_Missense_Mutation_p.N176S|RXFP1_uc011cjd.1_Missense_Mutation_p.N176S|RXFP1_uc010iql.2_Intron|RXFP1_uc011cje.1_Missense_Mutation_p.N284S|RXFP1_uc010iqm.2_Missense_Mutation_p.N224S|RXFP1_uc011cjf.1_Missense_Mutation_p.N127S|RXFP1_uc010iqn.2_Missense_Mutation_p.N203S	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	257	Extracellular (Potential).|LRR 5.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CTTGAAGGCAACCATATCCAT	0.264													24	37	---	---	---	---	PASS
DDX60	55601	broad.mit.edu	37	4	169173723	169173723	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169173723T>C	uc003irp.2	-	27	3934	c.3642A>G	c.(3640-3642)CTA>CTG	p.L1214L		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1214							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		GGTTCTTCTCTAGACACTTCA	0.388													117	143	---	---	---	---	PASS
GALNTL6	442117	broad.mit.edu	37	4	173269755	173269755	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:173269755C>A	uc003isv.2	+	5	1204	c.468C>A	c.(466-468)CTC>CTA	p.L156L		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	156	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GGACTTCACTCCTGCGGACCA	0.428													75	87	---	---	---	---	PASS
ASB5	140458	broad.mit.edu	37	4	177138028	177138028	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:177138028C>A	uc003iuq.1	-	6	819	c.803G>T	c.(802-804)CGA>CTA	p.R268L	ASB5_uc003iup.1_Missense_Mutation_p.R215L	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	268					intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		ATCTATAGGTCGCAGAAGCTC	0.368													44	83	---	---	---	---	PASS
PLEKHG4B	153478	broad.mit.edu	37	5	162987	162987	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:162987G>C	uc003jak.2	+	11	1782	c.1732G>C	c.(1732-1734)GGG>CGG	p.G578R		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	578					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TCATGCCCTGGGGAAACCGTG	0.647													6	9	---	---	---	---	PASS
TAS2R1	50834	broad.mit.edu	37	5	9629767	9629767	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:9629767G>A	uc003jem.1	-	1	697	c.378C>T	c.(376-378)GTC>GTT	p.V126V		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	126	Helical; Name=4; (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						TCATCCATGGGACCAGCTTGG	0.458													28	65	---	---	---	---	PASS
FAM173B	134145	broad.mit.edu	37	5	10239306	10239306	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:10239306G>C	uc003jeo.2	-	2	208	c.179C>G	c.(178-180)ACG>AGG	p.T60R	FAM173B_uc003jep.2_RNA|FAM173B_uc010itr.2_Missense_Mutation_p.T60R	NM_199133	NP_954584	Q6P4H8	F173B_HUMAN	hypothetical protein LOC134145	60						integral to membrane				kidney(1)|central_nervous_system(1)	2						AAGGGCTGGCGTTACAAACGG	0.502													16	146	---	---	---	---	PASS
PRDM9	56979	broad.mit.edu	37	5	23521285	23521285	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:23521285C>A	uc003jgo.2	+	6	687	c.505C>A	c.(505-507)CTG>ATG	p.L169M		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	169					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AAGACTAAAACTGGGTAAGAA	0.463										HNSCC(3;0.000094)			76	64	---	---	---	---	PASS
CDH9	1007	broad.mit.edu	37	5	26881478	26881478	+	Nonsense_Mutation	SNP	G	A	A	rs113264250		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:26881478G>A	uc003jgs.1	-	12	2306	c.2137C>T	c.(2137-2139)CAA>TAA	p.Q713*	CDH9_uc011cnv.1_Nonsense_Mutation_p.Q306*	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	713	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATAAAATCTTGTACATCAATA	0.418													128	123	---	---	---	---	PASS
ZFR	51663	broad.mit.edu	37	5	32380216	32380216	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32380216C>A	uc003jhr.1	-	16	2784	c.2704G>T	c.(2704-2706)GCT>TCT	p.A902S	ZFR_uc010ium.1_Missense_Mutation_p.A33S|ZFR_uc011cny.1_Intron	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	902	DZF.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		GCAGCCAGAGCGTCAAGGCAT	0.448													65	98	---	---	---	---	PASS
ADAMTS12	81792	broad.mit.edu	37	5	33576688	33576688	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33576688G>T	uc003jia.1	-	19	3606	c.3443C>A	c.(3442-3444)ACC>AAC	p.T1148N	ADAMTS12_uc010iuq.1_Missense_Mutation_p.T1063N	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1148	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGGACCTTTGGTCAAGGTATT	0.473										HNSCC(64;0.19)			51	166	---	---	---	---	PASS
RAI14	26064	broad.mit.edu	37	5	34811911	34811911	+	Silent	SNP	C	T	T	rs143309351		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:34811911C>T	uc003jir.2	+	9	793	c.597C>T	c.(595-597)AAC>AAT	p.N199N	RAI14_uc010iur.2_Silent_p.N199N|RAI14_uc011coj.1_Silent_p.N199N|RAI14_uc010ius.1_Silent_p.N128N|RAI14_uc003jis.2_Silent_p.N202N|RAI14_uc003jit.2_Silent_p.N199N|RAI14_uc011cok.1_Silent_p.N191N	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	199	ANK 6.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					GCAGCTCTAACGCTGTGGAAG	0.388													12	169	---	---	---	---	PASS
UGT3A2	167127	broad.mit.edu	37	5	36049139	36049139	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36049139C>T	uc003jjz.1	-	4	788	c.695G>A	c.(694-696)GGC>GAC	p.G232D	UGT3A2_uc011cos.1_Missense_Mutation_p.G198D|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	232	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGGCCTAGAGCCTTCTGTGAA	0.438													38	206	---	---	---	---	PASS
C6	729	broad.mit.edu	37	5	41181661	41181661	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41181661C>A	uc003jmk.2	-	7	937	c.727G>T	c.(727-729)GTA>TTA	p.V243L	C6_uc003jml.1_Missense_Mutation_p.V243L	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	243	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCAGTTTGTACCTGGAGAAAA	0.313													27	62	---	---	---	---	PASS
ERCC8	1161	broad.mit.edu	37	5	60214083	60214083	+	Intron	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:60214083T>A	uc003jsm.3	-						ERCC8_uc003jsl.3_Intron|ERCC8_uc011cqp.1_Intron|ERCC8_uc003jsn.3_Intron	NM_000082	NP_000073	Q13216	ERCC8_HUMAN	excision repair cross-complementing rodent						positive regulation of DNA repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein polyubiquitination|response to oxidative stress|response to UV|response to UV|transcription-coupled nucleotide-excision repair	Cul4A-RING ubiquitin ligase complex|nuclear matrix|nucleoplasm|nucleotide-excision repair complex|soluble fraction	protein binding|protein complex binding				0		Lung NSC(810;1.51e-06)|Prostate(74;0.0322)|Ovarian(174;0.0481)|Breast(144;0.077)				AATGTTTTAATGTACTTACTT	0.323								Direct_reversal_of_damage|NER					18	61	---	---	---	---	PASS
HTR1A	3350	broad.mit.edu	37	5	63256745	63256745	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:63256745C>A	uc011cqt.1	-	1	802	c.802G>T	c.(802-804)GAG>TAG	p.E268*		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	268	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCCTTGCTCTCCACGCCCAGC	0.667													39	64	---	---	---	---	PASS
CCNB1	891	broad.mit.edu	37	5	68470110	68470110	+	Silent	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68470110G>C	uc003jvm.2	+	5	756	c.579G>C	c.(577-579)CTG>CTC	p.L193L	CCNB1_uc011crd.1_Silent_p.L193L|CCNB1_uc010ixb.2_Silent_p.L193L	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	193					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		AATACCTACTGGGTCGGGAAG	0.418													47	62	---	---	---	---	PASS
ERAP2	64167	broad.mit.edu	37	5	96235862	96235862	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96235862G>T	uc003kmq.2	+	10	2251	c.1541G>T	c.(1540-1542)TGT>TTT	p.C514F	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.C514F|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.C463F|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	514	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		GGTGGAGTTTGTCATTCGGAT	0.403													54	81	---	---	---	---	PASS
GRAMD3	65983	broad.mit.edu	37	5	125816199	125816199	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:125816199T>G	uc003ktu.2	+	7	1064	c.634T>G	c.(634-636)TCT>GCT	p.S212A	GRAMD3_uc011cwt.1_Missense_Mutation_p.S227A|GRAMD3_uc011cwv.1_Missense_Mutation_p.S220A|GRAMD3_uc011cww.1_Missense_Mutation_p.S108A|GRAMD3_uc011cwx.1_RNA|GRAMD3_uc011cwy.1_Missense_Mutation_p.S103A|GRAMD3_uc011cwz.1_Missense_Mutation_p.S196A|GRAMD3_uc011cwu.1_Missense_Mutation_p.S196A	NM_023927	NP_076416	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3 isoform 2	212										central_nervous_system(1)	1		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		ACTACTAAAATCTGTGTGTGG	0.358													35	46	---	---	---	---	PASS
ACSL6	23305	broad.mit.edu	37	5	131323735	131323735	+	Intron	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:131323735C>A	uc010jdo.1	-						ACSL6_uc003kvv.1_Intron|ACSL6_uc003kvx.1_Intron|ACSL6_uc003kvy.1_Intron|ACSL6_uc003kwb.2_Intron|ACSL6_uc003kvz.1_Intron|ACSL6_uc003kwa.1_Intron|ACSL6_uc010jdn.1_Intron|ACSL6_uc010jdp.1_5'Flank	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6						fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGAAGCAGACCCTCACCTCCA	0.567													49	77	---	---	---	---	PASS
PCDHB1	29930	broad.mit.edu	37	5	140432759	140432759	+	Missense_Mutation	SNP	C	A	A	rs137984585	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140432759C>A	uc003lik.1	+	1	1781	c.1704C>A	c.(1702-1704)AAC>AAA	p.N568K		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	568	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACTGCAGAACGGCACCTTGC	0.522													37	51	---	---	---	---	PASS
PCDHGB2	56103	broad.mit.edu	37	5	140741405	140741405	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140741405G>T	uc003ljs.1	+	1	1703	c.1703G>T	c.(1702-1704)GGG>GTG	p.G568V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.G568V|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	568	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGCGCTGGGGCCTGATGGC	0.682													22	28	---	---	---	---	PASS
SLC36A1	206358	broad.mit.edu	37	5	150856315	150856315	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150856315C>A	uc003luc.2	+	9	1204	c.987C>A	c.(985-987)TGC>TGA	p.C329*	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Nonsense_Mutation_p.C329*|SLC36A1_uc010jhw.1_Nonsense_Mutation_p.C329*	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	329	Extracellular (Potential).			C->A,S: Abolishes the transport function.	cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TGCCCAACTGCTGGTACGTGG	0.483													3	42	---	---	---	---	PASS
NMUR2	56923	broad.mit.edu	37	5	151772031	151772031	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:151772031G>T	uc003luv.2	-	4	1135	c.969C>A	c.(967-969)AAC>AAA	p.N323K		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	323	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			AGATAATGGGGTTGACAGCTG	0.478													42	59	---	---	---	---	PASS
GRIA1	2890	broad.mit.edu	37	5	153056653	153056653	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153056653G>C	uc003lva.3	+	7	1326	c.961G>C	c.(961-963)GGG>CGG	p.G321R	GRIA1_uc003luy.3_Missense_Mutation_p.G321R|GRIA1_uc003luz.3_Missense_Mutation_p.G226R|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.G241R|GRIA1_uc011dcx.1_Missense_Mutation_p.G252R|GRIA1_uc011dcy.1_Missense_Mutation_p.G331R|GRIA1_uc011dcz.1_Missense_Mutation_p.G331R|GRIA1_uc010jia.1_Missense_Mutation_p.G301R	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	321	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGGGAATGCTGGGGATTGTCT	0.567													16	22	---	---	---	---	PASS
KIF4B	285643	broad.mit.edu	37	5	154393632	154393632	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154393632G>T	uc010jih.1	+	1	373	c.213G>T	c.(211-213)CCG>CCT	p.P71P		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	71	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAGTAGCGCCGCTCATAAAAG	0.463													34	43	---	---	---	---	PASS
CAGE1	285782	broad.mit.edu	37	6	7355339	7355339	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7355339T>C	uc003mxi.2	-	8	2431	c.1710A>G	c.(1708-1710)ACA>ACG	p.T570T	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Silent_p.T523T|CAGE1_uc003mxk.1_Silent_p.T488T	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	706											0	Ovarian(93;0.0418)					CTTCATATGATGTAACCTTGA	0.289													33	96	---	---	---	---	PASS
CAGE1	285782	broad.mit.edu	37	6	7373309	7373309	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7373309G>T	uc003mxi.2	-	4	2056	c.1335C>A	c.(1333-1335)ACC>ACA	p.T445T	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Silent_p.T336T|CAGE1_uc003mxk.1_Silent_p.T336T	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	581											0	Ovarian(93;0.0418)					TCAATACCTTGGTAATATCTG	0.373													7	39	---	---	---	---	PASS
TBC1D7	51256	broad.mit.edu	37	6	13306671	13306671	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13306671C>G	uc003naj.2	-	7	845	c.754G>C	c.(754-756)GCA>CCA	p.A252P	TBC1D7_uc011dis.1_Intron|TBC1D7_uc003nan.2_Missense_Mutation_p.A252P|TBC1D7_uc003nal.2_Missense_Mutation_p.A252P|TBC1D7_uc003nam.2_Missense_Mutation_p.A252P|TBC1D7_uc003nao.2_Missense_Mutation_p.A225P|TBC1D7_uc010jpd.2_Missense_Mutation_p.A206P|TBC1D7_uc003nap.2_3'UTR	NM_016495	NP_057579	Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7 isoform a	252					positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			ovary(1)	1	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			CTGTTCAGTGCCATAACTTTT	0.328													33	93	---	---	---	---	PASS
TBC1D7	51256	broad.mit.edu	37	6	13306672	13306672	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13306672C>A	uc003naj.2	-	7	844	c.753G>T	c.(751-753)ATG>ATT	p.M251I	TBC1D7_uc011dis.1_Intron|TBC1D7_uc003nan.2_Missense_Mutation_p.M251I|TBC1D7_uc003nal.2_Missense_Mutation_p.M251I|TBC1D7_uc003nam.2_Missense_Mutation_p.M251I|TBC1D7_uc003nao.2_Missense_Mutation_p.M224I|TBC1D7_uc010jpd.2_Missense_Mutation_p.M205I|TBC1D7_uc003nap.2_3'UTR	NM_016495	NP_057579	Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7 isoform a	251					positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			ovary(1)	1	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			TGTTCAGTGCCATAACTTTTA	0.333													33	94	---	---	---	---	PASS
HIST1H4K	8362	broad.mit.edu	37	6	27799312	27799312	+	5'Flank	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27799312C>T	uc003njr.2	-							NM_003541	NP_003532	P62805	H4_HUMAN	histone cluster 1, H4k						CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						ACATGACGAGCAAGAGGAGTC	0.587													10	56	---	---	---	---	PASS
PGBD1	84547	broad.mit.edu	37	6	28268912	28268912	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28268912T>C	uc003nky.2	+	7	1651	c.1281T>C	c.(1279-1281)TTT>TTC	p.F427F	PGBD1_uc003nkz.2_Silent_p.F427F	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	427					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AATTATTTTTTGATGATGAAA	0.358													67	134	---	---	---	---	PASS
OR12D3	81797	broad.mit.edu	37	6	29342776	29342776	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29342776T>C	uc003nme.2	-	1	293	c.289A>G	c.(289-291)ACC>GCC	p.T97A		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3						TGTAGCTGGGTGATACAGCCT	0.468													20	36	---	---	---	---	PASS
ABCF1	23	broad.mit.edu	37	6	30557481	30557481	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30557481G>T	uc003nql.2	+	21	2143	c.2048G>T	c.(2047-2049)AGA>ATA	p.R683I	ABCF1_uc003nqm.2_Missense_Mutation_p.R645I|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	683	ABC transporter 2.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						GGGGAAATGAGAAAGAACCAC	0.453													23	66	---	---	---	---	PASS
C4A	720	broad.mit.edu	37	6	31997032	31997032	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31997032A>G	uc011dpd.1	+	28	3644	c.3593A>G	c.(3592-3594)TAT>TGT	p.Y1198C	C4A_uc011dpe.1_Missense_Mutation_p.Y1198C	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	1198					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						ATCACGGCCTATGCCCTGACA	0.607													19	74	---	---	---	---	PASS
HLA-DRB1	3123	broad.mit.edu	37	6	32549334	32549334	+	Nonsense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32549334T>A	uc003obp.3	-	3	695	c.652A>T	c.(652-654)AGA>TGA	p.R218*	HLA-DRB1_uc011dqa.1_Nonsense_Mutation_p.R48*|HLA-DRB5_uc003obk.3_Intron|HLA-DRB6_uc003obo.1_Intron|uc010jub.1_5'Flank|HLA-DRB1_uc011dqb.1_Missense_Mutation_p.T48S|HLA-DRB1_uc011dqc.1_Nonsense_Mutation_p.R48*	NM_002124	NP_002115	P01911	2B1F_HUMAN	major histocompatibility complex, class II, DR	218	Beta-2.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				skin(1)	1						AGCTGCTCACTCCATTCCACT	0.512									Rheumatoid_Arthritis|Sj_gren_syndrome	Multiple Myeloma(14;0.17)			7	123	---	---	---	---	PASS
TAP2	6891	broad.mit.edu	37	6	32803537	32803537	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32803537C>T	uc003occ.2	-	3	653	c.622G>A	c.(622-624)GGC>AGC	p.G208S	TAP2_uc011dqf.1_Missense_Mutation_p.G208S|TAP2_uc003ocb.1_Missense_Mutation_p.G208S|TAP2_uc003ocd.2_Missense_Mutation_p.G208S	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	208	Helical; Name=5; (Potential).|ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						CCTCGGCAGCCTGCAGACAGT	0.582													37	79	---	---	---	---	PASS
ANKS1A	23294	broad.mit.edu	37	6	35027962	35027962	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35027962G>T	uc003ojx.3	+	13	2258	c.2116G>T	c.(2116-2118)GAG>TAG	p.E706*	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Nonsense_Mutation_p.E246*|ANKS1A_uc010jvp.1_Nonsense_Mutation_p.E80*	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	706	SAM 1.					cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						GGAGTGGCTGGAGTCGATTGG	0.552													4	10	---	---	---	---	PASS
SCUBE3	222663	broad.mit.edu	37	6	35209601	35209601	+	Missense_Mutation	SNP	C	A	A	rs148936412		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35209601C>A	uc003okf.1	+	12	1337	c.1331C>A	c.(1330-1332)ACG>AAG	p.T444K	SCUBE3_uc003okg.1_Missense_Mutation_p.T443K|SCUBE3_uc003okh.1_Missense_Mutation_p.T331K	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	444					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AATGGCTTCACGGTGAGCTGT	0.612											OREG0017372	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	40	---	---	---	---	PASS
BRPF3	27154	broad.mit.edu	37	6	36172574	36172574	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36172574C>T	uc003olv.3	+	3	1812	c.1588C>T	c.(1588-1590)CAA>TAA	p.Q530*	BRPF3_uc010jwb.2_Nonsense_Mutation_p.Q530*|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Nonsense_Mutation_p.Q530*	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	530					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						TCTGCAGTCCCAAAGAAACGC	0.547													41	133	---	---	---	---	PASS
DNAH8	1769	broad.mit.edu	37	6	38690853	38690853	+	5'UTR	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38690853C>A	uc003ooe.1	+	1					DNAH8_uc003ood.1_Missense_Mutation_p.P90T	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GAGGCTTGCACCGCGACCGGT	0.517													24	73	---	---	---	---	PASS
DNAH8	1769	broad.mit.edu	37	6	38831802	38831802	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38831802A>T	uc003ooe.1	+	43	6413	c.5813A>T	c.(5812-5814)GAT>GTT	p.D1938V		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GATTGTGTTGATTTAAATCCA	0.294													19	65	---	---	---	---	PASS
KIAA0240	23506	broad.mit.edu	37	6	42797882	42797882	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42797882C>G	uc003osn.1	+	6	1962	c.1811C>G	c.(1810-1812)ACA>AGA	p.T604R	KIAA0240_uc003osm.1_Missense_Mutation_p.T604R|KIAA0240_uc011duw.1_Missense_Mutation_p.T604R|KIAA0240_uc003oso.1_Missense_Mutation_p.T604R|KIAA0240_uc003osp.1_Missense_Mutation_p.T604R	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	604										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			ACACCTGGAACAGGAACCCAG	0.428													23	89	---	---	---	---	PASS
PGK2	5232	broad.mit.edu	37	6	49754834	49754834	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49754834C>G	uc003ozu.2	-	1	174	c.67G>C	c.(67-69)GTA>CTA	p.V23L		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	23					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					TTGAAGTCTACTCTCATGATG	0.428													38	132	---	---	---	---	PASS
TFAP2D	83741	broad.mit.edu	37	6	50682845	50682845	+	Nonsense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:50682845C>G	uc003paf.2	+	2	568	c.56C>G	c.(55-57)TCA>TGA	p.S19*	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	19							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					CACGACGGATCAAACAGCTAC	0.532													19	64	---	---	---	---	PASS
TFAP2D	83741	broad.mit.edu	37	6	50740364	50740364	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:50740364C>A	uc003paf.2	+	8	1658	c.1146C>A	c.(1144-1146)ATC>ATA	p.I382I	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	382	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					CCAGTTTGATCACTCATGGCT	0.378													22	40	---	---	---	---	PASS
COL21A1	81578	broad.mit.edu	37	6	56044420	56044420	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56044420G>T	uc003pcs.2	-	3	828	c.596C>A	c.(595-597)GCA>GAA	p.A199E	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.A199E|COL21A1_uc003pcu.1_Missense_Mutation_p.A199E	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	199	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTTGGATATTGCAATATAGTC	0.343													18	41	---	---	---	---	PASS
DST	667	broad.mit.edu	37	6	56458768	56458768	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56458768T>A	uc003pdf.2	-	42	6090	c.6062A>T	c.(6061-6063)GAT>GTT	p.D2021V	DST_uc003pcz.3_Missense_Mutation_p.D1843V|DST_uc011dxj.1_Missense_Mutation_p.D1872V|DST_uc011dxk.1_Missense_Mutation_p.D1883V|DST_uc003pcy.3_Missense_Mutation_p.D1517V|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3929	Spectrin 2.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATAGTCAGCATCAAACTTTTC	0.413													17	71	---	---	---	---	PASS
LGSN	51557	broad.mit.edu	37	6	63990387	63990387	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:63990387A>T	uc003peh.2	-	4	1103	c.1069T>A	c.(1069-1071)TGC>AGC	p.C357S	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	357					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	GCCATCAGGCAGCTGAGCGCA	0.498													43	126	---	---	---	---	PASS
FAM46A	55603	broad.mit.edu	37	6	82459917	82459917	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:82459917A>T	uc003pjg.2	-	3	1142	c.824T>A	c.(823-825)CTT>CAT	p.L275H	FAM46A_uc003pjf.2_Missense_Mutation_p.L294H	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	275											0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		CTTGTTACAAAGGTGATCAAA	0.502													31	79	---	---	---	---	PASS
IBTK	25998	broad.mit.edu	37	6	82881130	82881130	+	3'UTR	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:82881130C>A	uc003pjl.1	-	29					IBTK_uc011dyu.1_3'UTR|IBTK_uc011dyv.1_3'UTR|IBTK_uc011dyw.1_3'UTR|IBTK_uc010kbi.1_3'UTR	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase						negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TGCATCTCAACTCCACAGTGA	0.289													30	110	---	---	---	---	PASS
KIAA1009	22832	broad.mit.edu	37	6	84884584	84884584	+	Silent	SNP	C	G	G	rs143508247		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84884584C>G	uc010kbp.2	-	15	1984	c.1887G>C	c.(1885-1887)GCG>GCC	p.A629A	KIAA1009_uc003pkj.3_Silent_p.A553A|KIAA1009_uc003pkk.2_3'UTR|KIAA1009_uc003pki.3_Silent_p.A15A	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	629	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TTAGGGCTTGCGCACCCCTCC	0.373													7	32	---	---	---	---	PASS
HTR1E	3354	broad.mit.edu	37	6	87725512	87725512	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:87725512T>G	uc003pli.2	+	2	1163	c.460T>G	c.(460-462)TCC>GCC	p.S154A		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	154	Helical; Name=4; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CATTTTCATCTCCATGCCCCC	0.557													4	153	---	---	---	---	PASS
C6orf165	154313	broad.mit.edu	37	6	88136346	88136346	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88136346C>A	uc003plv.2	+	8	1035	c.943C>A	c.(943-945)CCA>ACA	p.P315T	C6orf165_uc003plw.2_Missense_Mutation_p.P127T|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.P315T	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	315										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		GATAGCGGTCCCAACATCACA	0.343													18	40	---	---	---	---	PASS
SIM1	6492	broad.mit.edu	37	6	100868805	100868805	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:100868805G>A	uc003pqj.3	-	9	1235	c.1028C>T	c.(1027-1029)TCC>TTC	p.S343F	SIM1_uc010kcu.2_Missense_Mutation_p.S343F	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	343	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CTGATCCAGGGAGAGCTGCAG	0.537													12	28	---	---	---	---	PASS
ASCC3	10973	broad.mit.edu	37	6	101311979	101311979	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:101311979C>T	uc003pqk.2	-	3	531	c.202G>A	c.(202-204)GAA>AAA	p.E68K	ASCC3_uc011eai.1_Intron|ASCC3_uc003pql.2_Missense_Mutation_p.E68K|ASCC3_uc010kcv.2_Missense_Mutation_p.E68K|ASCC3_uc003pqm.2_Missense_Mutation_p.E68K	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	68	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTTAAGTCTTCATTTATACTT	0.264													37	83	---	---	---	---	PASS
MICAL1	64780	broad.mit.edu	37	6	109766434	109766434	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109766434G>A	uc003ptj.2	-	21	3101	c.2847C>T	c.(2845-2847)GGC>GGT	p.G949G	MICAL1_uc003ptk.2_Silent_p.G949G|MICAL1_uc010kdr.2_Silent_p.G863G|MICAL1_uc011eaq.1_Silent_p.G968G	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	949	Potential.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CCAGCTTCACGCCCTCGGCCT	0.577													30	55	---	---	---	---	PASS
LAMA4	3910	broad.mit.edu	37	6	112451160	112451160	+	Nonsense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112451160T>A	uc003pvu.2	-	30	4360	c.4051A>T	c.(4051-4053)AAG>TAG	p.K1351*	LAMA4_uc003pvv.2_Nonsense_Mutation_p.K1344*|LAMA4_uc003pvt.2_Nonsense_Mutation_p.K1344*	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1351	Laminin G-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TAAAACTTCTTTTCACTTGCT	0.363													34	70	---	---	---	---	PASS
ROS1	6098	broad.mit.edu	37	6	117683881	117683881	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117683881G>C	uc003pxp.1	-	21	3465	c.3266C>G	c.(3265-3267)TCC>TGC	p.S1089C	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1089	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ACTTTGATTGGATATATTGTA	0.368			T	GOPC|ROS1	glioblastoma|NSCLC								4	163	---	---	---	---	PASS
GJA1	2697	broad.mit.edu	37	6	121768134	121768134	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121768134T>C	uc003pyr.2	+	2	391	c.141T>C	c.(139-141)GAT>GAC	p.D47D	GJA1_uc011ebo.1_5'UTR|GJA1_uc011ebp.1_5'UTR	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	47	Extracellular (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CCTGGGGAGATGAGCAGTCTG	0.512													39	91	---	---	---	---	PASS
NKAIN2	154215	broad.mit.edu	37	6	124676411	124676411	+	Splice_Site	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:124676411A>T	uc003pzo.2	+	3	470	c.193_splice	c.e3-2	p.Y65_splice	NKAIN2_uc003pzn.1_Splice_Site_p.Y65_splice|NKAIN2_uc003pzp.2_Splice_Site_p.Y64_splice|NKAIN2_uc010keq.2_Splice_Site_p.Y65_splice|NKAIN2_uc010ker.2_Splice_Site	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1							integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		GCTTCTCTACAGTATGCTGTC	0.373													81	168	---	---	---	---	PASS
NCOA7	135112	broad.mit.edu	37	6	126210679	126210679	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:126210679G>T	uc010kes.2	+	11	1928	c.1479G>T	c.(1477-1479)ATG>ATT	p.M493I	NCOA7_uc003qae.3_Missense_Mutation_p.M493I|NCOA7_uc003qah.2_Missense_Mutation_p.M482I|NCOA7_uc003qai.2_Missense_Mutation_p.M493I|NCOA7_uc010ket.2_Missense_Mutation_p.M378I	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	493					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		AAGATATAATGCCAGAAGTGG	0.418													4	88	---	---	---	---	PASS
C6orf174	387104	broad.mit.edu	37	6	127767951	127767951	+	3'UTR	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:127767951T>A	uc003qbd.2	-	11					C6orf174_uc003qbc.2_Missense_Mutation_p.M505L|C6orf174_uc003qba.2_Intron|C6orf174_uc003qbb.2_Missense_Mutation_p.M388L|KIAA0408_uc011ebs.1_Missense_Mutation_p.M505L	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor							integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		ACATTTTCCATGGGCACAGGC	0.463													21	57	---	---	---	---	PASS
C6orf174	387104	broad.mit.edu	37	6	127796469	127796469	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:127796469C>T	uc003qbd.2	-	6	3567	c.2702G>A	c.(2701-2703)CGC>CAC	p.R901H	C6orf174_uc003qbc.2_5'UTR	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	901						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CTCGGCGCCGCGGTCGTCCGC	0.667													37	66	---	---	---	---	PASS
LAMA2	3908	broad.mit.edu	37	6	129723463	129723463	+	Intron	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129723463T>A	uc003qbn.2	+						LAMA2_uc003qbo.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTTCTCTACATATCAGTATGT	0.348													21	41	---	---	---	---	PASS
BCLAF1	9774	broad.mit.edu	37	6	136599046	136599046	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136599046C>A	uc003qgx.1	-	4	1226	c.973G>T	c.(973-975)GGT>TGT	p.G325C	BCLAF1_uc003qgw.1_Missense_Mutation_p.G325C|BCLAF1_uc003qgy.1_Missense_Mutation_p.G323C|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.G323C	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	325					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGATCTCCACCATCAGGATAA	0.388													24	198	---	---	---	---	PASS
IFNGR1	3459	broad.mit.edu	37	6	137524818	137524818	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:137524818T>C	uc003qho.2	-	5	654	c.551A>G	c.(550-552)CAG>CGG	p.Q184R	IFNGR1_uc011edm.1_Missense_Mutation_p.Q156R|IFNGR1_uc011edn.1_3'UTR	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	184	Extracellular (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	TATTTTATACTGGATCTAGAT	0.358													16	66	---	---	---	---	PASS
GPR126	57211	broad.mit.edu	37	6	142736163	142736163	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:142736163A>C	uc010khc.2	+	19	3010	c.2599A>C	c.(2599-2601)ATC>CTC	p.I867L	GPR126_uc010khd.2_Missense_Mutation_p.I839L|GPR126_uc010khe.2_Missense_Mutation_p.I867L|GPR126_uc010khf.2_Missense_Mutation_p.I839L	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	867	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CCTCACTTTCATCAGCTATAT	0.393													4	109	---	---	---	---	PASS
GRM1	2911	broad.mit.edu	37	6	146480689	146480689	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146480689C>T	uc010khw.1	+	3	1376	c.906C>T	c.(904-906)GCC>GCT	p.A302A	GRM1_uc010khu.1_Silent_p.A302A|GRM1_uc010khv.1_Silent_p.A302A|GRM1_uc003qll.2_Silent_p.A302A|GRM1_uc011edz.1_Silent_p.A302A|GRM1_uc011eea.1_Silent_p.A302A	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	302	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TCCTGAGCGCCATGCGGCGCC	0.438													17	76	---	---	---	---	PASS
GRM1	2911	broad.mit.edu	37	6	146755690	146755690	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146755690C>G	uc010khw.1	+	9	3813	c.3343C>G	c.(3343-3345)CGG>GGG	p.R1115G	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1115	Asp/Glu-rich (acidic).|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGAGCACGAGCGGGAAGGGAA	0.632													47	119	---	---	---	---	PASS
LATS1	9113	broad.mit.edu	37	6	150023190	150023190	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:150023190C>A	uc003qmu.1	-	2	621	c.73G>T	c.(73-75)GTC>TTC	p.V25F	LATS1_uc010kif.1_5'UTR|LATS1_uc003qmv.1_Missense_Mutation_p.V25F|LATS1_uc003qmw.2_Missense_Mutation_p.V25F|LATS1_uc010kig.1_5'UTR	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	25					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		CGGCTACTGACAGTATAGTTA	0.408													41	130	---	---	---	---	PASS
RGS17	26575	broad.mit.edu	37	6	153332881	153332881	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:153332881C>A	uc003qpm.2	-	5	617	c.461G>T	c.(460-462)CGA>CTA	p.R154L		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	154	RGS.				negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		CTCTCTAACTCGAGAATCAAG	0.318									Lung_Cancer_Familial_Clustering_of				3	104	---	---	---	---	PASS
RBM16	22828	broad.mit.edu	37	6	155116180	155116180	+	Silent	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155116180C>G	uc003qqa.2	+	7	745	c.513C>G	c.(511-513)GTC>GTG	p.V171V	RBM16_uc011efj.1_Silent_p.V237V|RBM16_uc011efk.1_Silent_p.V216V|RBM16_uc003qpz.2_Silent_p.V171V|RBM16_uc010kji.2_Silent_p.V192V	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	171					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		CCAATGTGGTCCAAGGCTTAC	0.443													13	187	---	---	---	---	PASS
RSPH3	83861	broad.mit.edu	37	6	159404818	159404818	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:159404818G>C	uc003qrx.2	-	4	984	c.794C>G	c.(793-795)GCT>GGT	p.A265G	RSPH3_uc010kju.2_Intron|RSPH3_uc003qry.1_Missense_Mutation_p.A265G	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	265										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		TATGCGATCAGCAATTTCTTC	0.289													3	130	---	---	---	---	PASS
LPA	4018	broad.mit.edu	37	6	160978440	160978440	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160978440C>T	uc003qtl.2	-	30	4915	c.4795G>A	c.(4795-4797)GAG>AAG	p.E1599K		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4107	Kringle 36.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GAATGAGCCTCCATGCTTGGA	0.463													50	116	---	---	---	---	PASS
C6orf118	168090	broad.mit.edu	37	6	165693545	165693545	+	3'UTR	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:165693545G>A	uc003qum.3	-	9						NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090												0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCACTTGAGCGTTATCTTCTG	0.323													29	60	---	---	---	---	PASS
BRP44L	51660	broad.mit.edu	37	6	166780282	166780282	+	Splice_Site	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:166780282C>T	uc011egn.1	-	2	294	c.172_splice	c.e2+1	p.A58_splice	BRP44L_uc003qva.2_Splice_Site	NM_016098	NP_057182	Q9Y5U8	BR44L_HUMAN	brain protein 44-like							mitochondrion				central_nervous_system(1)	1		Breast(66;0.000148)|Prostate(117;0.109)|Ovarian(120;0.199)		OV - Ovarian serous cystadenocarcinoma(33;1.8e-19)|BRCA - Breast invasive adenocarcinoma(81;4.68e-06)|GBM - Glioblastoma multiforme(31;0.000122)		TGCATTCTTACCAAATGTCAT	0.433													64	156	---	---	---	---	PASS
KIF25	3834	broad.mit.edu	37	6	168440882	168440882	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:168440882G>A	uc003qwk.1	+	6	894	c.632G>A	c.(631-633)TGC>TAC	p.C211Y	KIF25_uc003qwl.1_Missense_Mutation_p.C211Y	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	211	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		ACAGCCTCCTGCTCTGACAGC	0.458													11	27	---	---	---	---	PASS
THBS2	7058	broad.mit.edu	37	6	169632797	169632797	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:169632797C>A	uc003qwt.2	-	13	2142	c.1894G>T	c.(1894-1896)GTC>TTC	p.V632F		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	632	EGF-like 2; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CCGACCCCGACGGGCTGGTTC	0.607													36	92	---	---	---	---	PASS
SUN1	23353	broad.mit.edu	37	7	908998	908998	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:908998C>T	uc011jvp.1	+	18	2072	c.1993C>T	c.(1993-1995)CCC>TCC	p.P665S	GET4_uc003sjj.1_Intron|SUN1_uc003sjf.2_Missense_Mutation_p.P582S|SUN1_uc011jvq.1_Missense_Mutation_p.P562S|SUN1_uc003sjg.2_Missense_Mutation_p.P570S|SUN1_uc011jvr.1_Missense_Mutation_p.P463S|SUN1_uc003sji.2_Missense_Mutation_p.P503S|SUN1_uc003sjk.2_Missense_Mutation_p.P304S	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	692	Perinuclear space.|SUN.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						TGACATTTACCCCGGTAACTG	0.522													82	244	---	---	---	---	PASS
GET4	51608	broad.mit.edu	37	7	925710	925710	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:925710A>T	uc003sjl.1	+	2	265	c.173A>T	c.(172-174)AAG>ATG	p.K58M	GET4_uc003sjj.1_RNA	NM_015949	NP_057033	Q7L5D6	GET4_HUMAN	hypothetical protein LOC51608	58					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding				0						TCCCAGAGCAAGCACACGGAG	0.622													14	63	---	---	---	---	PASS
PAPOLB	56903	broad.mit.edu	37	7	4901270	4901270	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4901270C>T	uc003snk.2	-	1	356	c.172G>A	c.(172-174)GAA>AAA	p.E58K	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	57					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		CGCTGCAGTTCCTCTTCCTCT	0.488													9	31	---	---	---	---	PASS
COL28A1	340267	broad.mit.edu	37	7	7472140	7472140	+	Silent	SNP	C	T	T	rs115295026	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7472140C>T	uc003src.1	-	25	2079	c.1962G>A	c.(1960-1962)CCG>CCA	p.P654P	COL28A1_uc011jxe.1_Silent_p.P337P|COL28A1_uc003srd.2_Silent_p.P209P|COL28A1_uc003sre.1_Silent_p.P75P	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	654					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GTAAACCCATCGGCCCAGGGG	0.512													29	97	---	---	---	---	PASS
MEOX2	4223	broad.mit.edu	37	7	15725582	15725582	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:15725582T>C	uc003stc.2	-	1	727	c.446A>G	c.(445-447)TAC>TGC	p.Y149C	MEOX2_uc011jxw.1_Missense_Mutation_p.Y149C	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	149					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		CTGGCGGCCGTAGTCCCCCGG	0.706													36	58	---	---	---	---	PASS
DNAH11	8701	broad.mit.edu	37	7	21778329	21778329	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21778329G>C	uc003svc.2	+	48	7708	c.7677G>C	c.(7675-7677)GAG>GAC	p.E2559D		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2559	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AAATTCTTGAGAAACCCCTAG	0.333									Kartagener_syndrome				5	3	---	---	---	---	PASS
MPP6	51678	broad.mit.edu	37	7	24705258	24705258	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:24705258C>A	uc003swx.2	+	8	1134	c.835C>A	c.(835-837)CTG>ATG	p.L279M	MPP6_uc003swy.2_Missense_Mutation_p.L279M|MPP6_uc010kur.2_5'Flank	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	279	SH3.				protein complex assembly		protein binding				0						AAGCCAGTTCCTGGAAGAGAA	0.428													4	103	---	---	---	---	PASS
WIPF3	644150	broad.mit.edu	37	7	29915547	29915547	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:29915547G>T	uc003taj.1	+	2	192	c.192G>T	c.(190-192)CAG>CAT	p.Q64H		NM_001080529	NP_001073998	A6NGB9	WIPF3_HUMAN	WAS/WASL interacting protein family, member 3	64										ovary(1)	1						AAGTCACGCAGATCAACGACC	0.602													25	40	---	---	---	---	PASS
ADCYAP1R1	117	broad.mit.edu	37	7	31123863	31123863	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:31123863C>G	uc003tca.1	+	7	659	c.436C>G	c.(436-438)CAG>GAG	p.Q146E	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.Q125E|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.Q146E|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.Q146E|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.Q146E|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	146	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						GACTGGGGACCAGGTGAGTGT	0.552													10	45	---	---	---	---	PASS
ADCYAP1R1	117	broad.mit.edu	37	7	31124950	31124950	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:31124950A>G	uc003tca.1	+	9	785	c.562A>G	c.(562-564)ATC>GTC	p.I188V	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.I167V|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.I188V|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.I188V|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.I188V|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	188	Helical; Name=2; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						ACGCAACTTCATCCACATGAA	0.532													56	103	---	---	---	---	PASS
PDE1C	5137	broad.mit.edu	37	7	32209413	32209413	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32209413C>A	uc003tco.1	-	3	886	c.292G>T	c.(292-294)GTG>TTG	p.V98L		NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	Error:Variant_position_missing_in_Q14123_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			GATGTCTTCACCAAGACTTCT	0.473													5	54	---	---	---	---	PASS
TBX20	57057	broad.mit.edu	37	7	35244188	35244188	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35244188A>G	uc011kas.1	-	7	908	c.897T>C	c.(895-897)AGT>AGC	p.S299S		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	299						nucleus	DNA binding			central_nervous_system(1)	1						GGCTCTCCACACTTTCCCTAG	0.448													13	22	---	---	---	---	PASS
ELMO1	9844	broad.mit.edu	37	7	37283952	37283952	+	Intron	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:37283952T>C	uc003tfk.1	-						ELMO1_uc011kbc.1_Intron|ELMO1_uc010kxg.1_Intron	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1						actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						ATCGATCAAATATTCTTACCA	0.343													66	140	---	---	---	---	PASS
PGAM2	5224	broad.mit.edu	37	7	44104982	44104982	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44104982C>T	uc003tjs.2	-	1	182	c.147G>A	c.(145-147)AAG>AAA	p.K49K		NM_000290	NP_000281	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2	49					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity				0						CAAACTCCATCTTGGCATCCT	0.607													24	68	---	---	---	---	PASS
PHTF2	57157	broad.mit.edu	37	7	77579098	77579098	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:77579098G>T	uc003ugs.3	+	16	2189	c.2063G>T	c.(2062-2064)GGA>GTA	p.G688V	PHTF2_uc003ugq.3_Missense_Mutation_p.G650V|PHTF2_uc010ldv.2_Intron|PHTF2_uc003ugt.3_Missense_Mutation_p.G654V|PHTF2_uc003ugu.3_Missense_Mutation_p.G650V	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	688					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						GTTACCCTTGGATCAGAAACA	0.333													7	19	---	---	---	---	PASS
PCLO	27445	broad.mit.edu	37	7	82595319	82595319	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82595319T>G	uc003uhx.2	-	4	4074	c.3785A>C	c.(3784-3786)CAT>CCT	p.H1262P	PCLO_uc003uhv.2_Missense_Mutation_p.H1262P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1201					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AAGTAAGTCATGTTTCTGTTC	0.423													8	282	---	---	---	---	PASS
SEMA3D	223117	broad.mit.edu	37	7	84644417	84644417	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:84644417C>T	uc003uic.2	-	14	1701	c.1661G>A	c.(1660-1662)TGG>TAG	p.W554*	SEMA3D_uc010led.2_Nonsense_Mutation_p.W554*|SEMA3D_uc003uib.2_Nonsense_Mutation_p.W193*	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	554	PSI.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						ATTTCCATCCCAGGCACAGTA	0.473													42	101	---	---	---	---	PASS
SEMA3D	223117	broad.mit.edu	37	7	84702362	84702362	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:84702362G>A	uc003uic.2	-	4	451	c.411C>T	c.(409-411)CCC>CCT	p.P137P	SEMA3D_uc010led.2_Silent_p.P137P|SEMA3D_uc010lee.1_Silent_p.P137P	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	137	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TTTTGTTATAGGGCTGAAGTA	0.328													32	89	---	---	---	---	PASS
ADAM22	53616	broad.mit.edu	37	7	87774742	87774742	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87774742G>A	uc003ujn.2	+	17	1484	c.1405G>A	c.(1405-1407)GAA>AAA	p.E469K	ADAM22_uc003ujk.1_Missense_Mutation_p.E469K|ADAM22_uc003ujl.1_Missense_Mutation_p.E469K|ADAM22_uc003ujm.2_Missense_Mutation_p.E469K|ADAM22_uc003ujo.2_Missense_Mutation_p.E469K|ADAM22_uc003ujp.1_Missense_Mutation_p.E521K	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	469	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ATGTGTCCTTGAAGGAGCAGA	0.353													40	116	---	---	---	---	PASS
STEAP1	26872	broad.mit.edu	37	7	89791223	89791223	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:89791223G>T	uc003ujx.2	+						STEAP1_uc010lem.2_Intron	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the						electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					TTTACCTTCTGGTAGGTCCAA	0.398													40	83	---	---	---	---	PASS
PEX1	5189	broad.mit.edu	37	7	92134131	92134131	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92134131A>G	uc003uly.2	-	12	2082	c.1986T>C	c.(1984-1986)GAT>GAC	p.D662D	PEX1_uc011khr.1_Silent_p.D454D|PEX1_uc010ley.2_Intron|PEX1_uc011khs.1_Silent_p.D340D|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	662			Missing (in NALD).		microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GGTCAAGGTCATCCAGCAGGA	0.507													82	217	---	---	---	---	PASS
CALCR	799	broad.mit.edu	37	7	93065476	93065476	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:93065476A>C	uc003umv.1	-	13	1300	c.1039T>G	c.(1039-1041)TTC>GTC	p.F347V	CALCR_uc011kia.1_Missense_Mutation_p.F127V|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.F313V|CALCR_uc003umw.2_Missense_Mutation_p.F313V	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	329	Helical; Name=5; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	AAAAAGAAGAAATTGACCTGC	0.423													17	36	---	---	---	---	PASS
MUC17	140453	broad.mit.edu	37	7	100677255	100677255	+	Missense_Mutation	SNP	C	A	A	rs140905069		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100677255C>A	uc003uxp.1	+	3	2611	c.2558C>A	c.(2557-2559)ACC>AAC	p.T853N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	853	Extracellular (Potential).|12.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCTGAAGGTACCAGCATGCCA	0.488													123	375	---	---	---	---	PASS
MUC17	140453	broad.mit.edu	37	7	100684625	100684625	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100684625A>T	uc003uxp.1	+	3	9981	c.9928A>T	c.(9928-9930)ACA>TCA	p.T3310S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3310	Extracellular (Potential).|54.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TGACACCAGCACACCTGTGAC	0.488													95	260	---	---	---	---	PASS
MOGAT3	346606	broad.mit.edu	37	7	100842049	100842049	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100842049C>T	uc003uyc.2	-	4	518	c.351G>A	c.(349-351)GGG>GGA	p.G117G	MOGAT3_uc010lhr.2_Silent_p.G117G	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	117					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					TACACATGATCCCATGAGGGT	0.612													46	104	---	---	---	---	PASS
PUS7	54517	broad.mit.edu	37	7	105099694	105099694	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105099694T>C	uc003vcx.2	-	15	1989	c.1770A>G	c.(1768-1770)GCA>GCG	p.A590A	PUS7_uc010lji.2_Silent_p.A596A|PUS7_uc003vcy.2_Silent_p.A590A|PUS7_uc003vcz.1_Silent_p.A590A	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	590					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						GATCATCATATGCAACGACTT	0.363													27	70	---	---	---	---	PASS
CBLL1	79872	broad.mit.edu	37	7	107398830	107398830	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107398830A>G	uc003veq.2	+	6	1013	c.683A>G	c.(682-684)CAT>CGT	p.H228R	CBLL1_uc011kme.1_Missense_Mutation_p.H107R|CBLL1_uc011kmf.1_Missense_Mutation_p.H227R	NM_024814	NP_079090	Q75N03	HAKAI_HUMAN	Cas-Br-M (murine) ecotropic retroviral	228	Pro-rich.				cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|skin(2)|lung(1)	5						GACAAGCACCATATGAGCCAT	0.468													63	147	---	---	---	---	PASS
IMMP2L	83943	broad.mit.edu	37	7	110603570	110603570	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:110603570T>C	uc003vfq.1	-	4	734	c.291A>G	c.(289-291)GAA>GAG	p.E97E	IMMP2L_uc010ljr.1_Silent_p.E97E|IMMP2L_uc003vfr.2_Silent_p.E97E	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	97					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		CAATATCTCCTTCAAGAGCAA	0.328													29	70	---	---	---	---	PASS
PTPRZ1	5803	broad.mit.edu	37	7	121653494	121653494	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121653494G>A	uc003vjy.2	+	12	4789	c.4394G>A	c.(4393-4395)AGT>AAT	p.S1465N	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1465	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CACGAAAACAGTCTTATGGAT	0.378													17	107	---	---	---	---	PASS
IQUB	154865	broad.mit.edu	37	7	123119903	123119903	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123119903T>C	uc003vkn.2	-	8	1933	c.1356A>G	c.(1354-1356)AGA>AGG	p.R452R	IQUB_uc003vko.2_Silent_p.R452R|IQUB_uc010lkt.2_Intron|IQUB_uc003vkp.1_Silent_p.R452R	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	452										ovary(3)|large_intestine(1)	4						AAGCAATGTATCTATGTCTCC	0.358													40	88	---	---	---	---	PASS
GRM8	2918	broad.mit.edu	37	7	126173774	126173774	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:126173774T>A	uc003vlr.2	-	8	1973	c.1662A>T	c.(1660-1662)GAA>GAT	p.E554D	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.E554D|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	554	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GAGGGCAAAGTTCACAGGACA	0.552										HNSCC(24;0.065)			40	100	---	---	---	---	PASS
MIR490	574443	broad.mit.edu	37	7	136587972	136587972	+	RNA	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:136587972C>G	hsa-mir-490|MI0003125	+			c.59C>G			CHRM2_uc003vtf.1_Intron|CHRM2_uc003vtg.1_Intron|CHRM2_uc003vtj.1_Intron|CHRM2_uc003vtk.1_Intron|CHRM2_uc003vtl.1_Intron|CHRM2_uc003vtm.1_Intron|CHRM2_uc003vti.1_Intron|CHRM2_uc003vto.1_Intron|CHRM2_uc003vtn.1_Intron|uc003vtp.1_Intron																	0						CCAGGTGGGTCAAGTTTAGAG	0.493													48	116	---	---	---	---	PASS
MGAM	8972	broad.mit.edu	37	7	141740548	141740548	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141740548A>G	uc003vwy.2	+	21	2454	c.2400A>G	c.(2398-2400)CAA>CAG	p.Q800Q		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	800	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGAGGAAGCAAAAAGTCGAGA	0.478													12	33	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	7	142423439	142423439	+	Intron	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142423439C>G	uc011krr.1	+						uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_5'Flank|uc011ksg.1_Intron|uc010lol.1_Missense_Mutation_p.T32R|uc011ksj.1_RNA					SubName: Full=V_segment translation product; Flags: Fragment;																		TACCTCATCACAGTGACTGGA	0.502													33	63	---	---	---	---	PASS
OR6V1	346517	broad.mit.edu	37	7	142749667	142749667	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142749667C>A	uc011ksv.1	+	1	230	c.230C>A	c.(229-231)CCC>CAC	p.P77H		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	77	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					ACTGCAGTGCCCAGGATGCTC	0.507													82	200	---	---	---	---	PASS
OR2F2	135948	broad.mit.edu	37	7	143632563	143632563	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143632563C>T	uc011ktv.1	+	1	238	c.238C>T	c.(238-240)CAG>TAG	p.Q80*		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					CGTAGTCCCCCAGCTGCTGGC	0.512													106	266	---	---	---	---	PASS
ZNF398	57541	broad.mit.edu	37	7	148851301	148851301	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148851301G>C	uc003wfl.2	+	2	564	c.289G>C	c.(289-291)GCC>CCC	p.A97P	ZNF398_uc011kul.1_5'UTR|ZNF398_uc011kum.1_Missense_Mutation_p.A102P	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	97					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			GGGCAAGTGGGCCGTGCTGGG	0.592													31	103	---	---	---	---	PASS
ZNF398	57541	broad.mit.edu	37	7	148851390	148851390	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148851390G>T	uc003wfl.2	+	2	653	c.378G>T	c.(376-378)TGG>TGT	p.W126C	ZNF398_uc011kul.1_5'UTR|ZNF398_uc011kum.1_Missense_Mutation_p.W131C	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	126					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			GGAACTTCTGGATCCTGCGGC	0.522													40	67	---	---	---	---	PASS
SSPO	23145	broad.mit.edu	37	7	149514991	149514991	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149514991C>G	uc010lpk.2	+	81	11381	c.11381C>G	c.(11380-11382)TCG>TGG	p.S3794W		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3794					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCCCCCAGCTCGTGTGCACAC	0.662													8	34	---	---	---	---	PASS
MLL3	58508	broad.mit.edu	37	7	151919670	151919670	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151919670G>A	uc003wla.2	-	21	3640	c.3421C>T	c.(3421-3423)CCT>TCT	p.P1141S	MLL3_uc003wkz.2_Missense_Mutation_p.P202S	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1141					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTAGACGCAGGCATATAGGGT	0.398			N		medulloblastoma								4	62	---	---	---	---	PASS
CSMD1	64478	broad.mit.edu	37	8	3165281	3165281	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:3165281C>A	uc011kwk.1	-	25	4279	c.3889G>T	c.(3889-3891)GCT>TCT	p.A1297S	CSMD1_uc011kwj.1_Missense_Mutation_p.A689S|CSMD1_uc003wqe.2_Missense_Mutation_p.A453S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1297	Extracellular (Potential).|CUB 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCATACGGAGCTGGATAGCCA	0.468													68	89	---	---	---	---	PASS
DLC1	10395	broad.mit.edu	37	8	12943812	12943812	+	Silent	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12943812T>G	uc003wwm.2	-	17	4897	c.4453A>C	c.(4453-4455)AGA>CGA	p.R1485R	DLC1_uc003wwk.1_Silent_p.R1048R|DLC1_uc003wwl.1_Silent_p.R1082R|DLC1_uc011kxx.1_Silent_p.R974R	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1485	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						AAGTCAACTCTGCACATGTAG	0.423													32	47	---	---	---	---	PASS
STC1	6781	broad.mit.edu	37	8	23708998	23708998	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23708998A>T	uc003xdw.1	-	3	592	c.308T>A	c.(307-309)GTC>GAC	p.V103D		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	103					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		CTTGGAGGTGACCCCGTTGGC	0.517													12	48	---	---	---	---	PASS
UNC5D	137970	broad.mit.edu	37	8	35583956	35583956	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:35583956C>A	uc003xjr.1	+	10	1918	c.1590C>A	c.(1588-1590)ATC>ATA	p.I530I	UNC5D_uc003xjs.1_Silent_p.I525I|UNC5D_uc003xju.1_Silent_p.I106I|UNC5D_uc003xjt.1_Silent_p.I288I	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	530	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGCCCTACATCCAAAATCTGT	0.473													58	83	---	---	---	---	PASS
ADAM18	8749	broad.mit.edu	37	8	39537603	39537603	+	Missense_Mutation	SNP	C	A	A	rs140616028		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39537603C>A	uc003xni.2	+	16	1679	c.1679C>A	c.(1678-1680)GCT>GAT	p.A560D	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.A536D	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	560	Cys-rich.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CATAAAAATGCTAATAAAAGT	0.363													22	99	---	---	---	---	PASS
ADAM2	2515	broad.mit.edu	37	8	39624421	39624421	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39624421T>A	uc003xnj.2	-	14	1528	c.1453A>T	c.(1453-1455)ATA>TTA	p.I485L	ADAM2_uc003xnk.2_Missense_Mutation_p.I466L|ADAM2_uc011lck.1_Missense_Mutation_p.I485L|ADAM2_uc003xnl.2_Missense_Mutation_p.I359L	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	485	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ACTCCATCTATACAGATCCAT	0.393													71	150	---	---	---	---	PASS
ZMAT4	79698	broad.mit.edu	37	8	40438772	40438772	+	Missense_Mutation	SNP	G	T	T	rs144919411	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:40438772G>T	uc003xnr.2	-	6	732	c.586C>A	c.(586-588)CGC>AGC	p.R196S	ZMAT4_uc003xns.2_Missense_Mutation_p.R120S	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	196						nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			CTGTAATTGCGCCTCAGACCT	0.463													23	90	---	---	---	---	PASS
POTEA	340441	broad.mit.edu	37	8	43197461	43197461	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:43197461G>C	uc003xpz.1	+	11	1393	c.1350G>C	c.(1348-1350)ATG>ATC	p.M450I	POTEA_uc003xqa.1_Missense_Mutation_p.M404I	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	450										ovary(1)	1						AACTCAAAATGGATTTTAACG	0.368													53	124	---	---	---	---	PASS
RP1	6101	broad.mit.edu	37	8	55533890	55533890	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:55533890C>T	uc003xsd.1	+	2	512	c.364C>T	c.(364-366)CGG>TGG	p.R122W	RP1_uc011ldy.1_Missense_Mutation_p.R122W	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	122					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CAAAGCCCGTCGGCGCCCGCG	0.711													35	41	---	---	---	---	PASS
ASPH	444	broad.mit.edu	37	8	62460751	62460751	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62460751T>A	uc003xuj.2	-	21	1912	c.1643A>T	c.(1642-1644)GAG>GTG	p.E548V	ASPH_uc011leg.1_Missense_Mutation_p.E519V	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	548	TPR 4.|Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	GTGCCCAAGCTCATACCACTT	0.388													31	102	---	---	---	---	PASS
SLCO5A1	81796	broad.mit.edu	37	8	70585235	70585235	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:70585235C>A	uc003xyl.2	-	10	3123	c.2416G>T	c.(2416-2418)GAA>TAA	p.E806*	SLCO5A1_uc010lzb.2_Nonsense_Mutation_p.E751*|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	806	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCAGTCTCTTCGTGGAATTCT	0.587													61	77	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77616444	77616444	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77616444G>T	uc003yav.2	+	2	508	c.121G>T	c.(121-123)GAC>TAC	p.D41Y	ZFHX4_uc003yat.1_Missense_Mutation_p.D41Y|ZFHX4_uc003yau.1_Missense_Mutation_p.D41Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.D41Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	41						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GATGGAGCCTGACAGGGAAAA	0.498										HNSCC(33;0.089)			7	71	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77766009	77766009	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77766009T>A	uc003yav.2	+	10	7104	c.6717T>A	c.(6715-6717)AGT>AGA	p.S2239R	ZFHX4_uc003yau.1_Missense_Mutation_p.S2284R|ZFHX4_uc003yaw.1_Missense_Mutation_p.S2239R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2239	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACGAAAGAGTTATGAGAATC	0.388										HNSCC(33;0.089)			18	21	---	---	---	---	PASS
WWP1	11059	broad.mit.edu	37	8	87424104	87424104	+	Splice_Site	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:87424104G>T	uc003ydt.2	+	9	1341	c.1061_splice	c.e9+1	p.G354_splice	WWP1_uc010mai.2_Splice_Site_p.G130_splice	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase						central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						TGCCATCAGGGTATGTTAAGC	0.403													20	78	---	---	---	---	PASS
CPNE3	8895	broad.mit.edu	37	8	87549866	87549866	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:87549866C>T	uc003ydv.2	+	7	697	c.535C>T	c.(535-537)CGG>TGG	p.R179W		NM_003909	NP_003900	O75131	CPNE3_HUMAN	copine III	179	C2 2.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			ovary(1)|skin(1)	2						AATGGTTCATCGGACAGAGGT	0.323													53	88	---	---	---	---	PASS
TMEM55A	55529	broad.mit.edu	37	8	92008056	92008056	+	Intron	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:92008056A>G	uc003yes.2	-							NM_018710	NP_061180	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A							integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0			BRCA - Breast invasive adenocarcinoma(11;0.033)			AACCTAAAATAAAAAGCAATA	0.363													13	69	---	---	---	---	PASS
SPAG1	6674	broad.mit.edu	37	8	101252883	101252883	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:101252883C>G	uc003yjh.1	+	18	2619	c.2533C>G	c.(2533-2535)CTT>GTT	p.L845V	SPAG1_uc003yji.1_Missense_Mutation_p.L845V	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	845					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		AAGTAACAAACTTGAAGGGGA	0.368													59	66	---	---	---	---	PASS
RSPO2	340419	broad.mit.edu	37	8	108970453	108970453	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:108970453G>T	uc003yms.2	-	5	1129	c.471C>A	c.(469-471)AGC>AGA	p.S157R	RSPO2_uc003ymq.2_Missense_Mutation_p.S90R|RSPO2_uc003ymr.2_Missense_Mutation_p.S93R	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	157	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			GATTATTTCTGCTACAAGTTC	0.373													95	117	---	---	---	---	PASS
RSPO2	340419	broad.mit.edu	37	8	108972938	108972938	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:108972938C>A	uc003yms.2	-	4	1049	c.391G>T	c.(391-393)GGT>TGT	p.G131C	RSPO2_uc003ymq.2_Missense_Mutation_p.G64C|RSPO2_uc003ymr.2_Missense_Mutation_p.G68C	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	131	FU.				Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			GGTGCAAAACCATCTGGACAT	0.348													31	129	---	---	---	---	PASS
RSPO2	340419	broad.mit.edu	37	8	109001408	109001408	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:109001408G>C	uc003yms.2	-	3	817	c.159C>G	c.(157-159)AGC>AGG	p.S53R	RSPO2_uc003ymq.2_5'UTR|RSPO2_uc003ymr.2_Intron	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	53					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			GTTGACATCGGCTACACCCAT	0.428													61	60	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113331147	113331147	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113331147A>T	uc003ynu.2	-	47	7438	c.7279T>A	c.(7279-7281)TTT>ATT	p.F2427I	CSMD3_uc003yns.2_Missense_Mutation_p.F1629I|CSMD3_uc003ynt.2_Missense_Mutation_p.F2387I|CSMD3_uc011lhx.1_Missense_Mutation_p.F2323I|CSMD3_uc003ynw.1_Missense_Mutation_p.F138I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2427	Extracellular (Potential).|Sushi 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTAAAGTAAATCCTGGAAGA	0.368										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			34	97	---	---	---	---	PASS
SLC30A8	169026	broad.mit.edu	37	8	118159291	118159291	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:118159291C>A	uc003yoh.2	+	2	400	c.170C>A	c.(169-171)TCC>TAC	p.S57Y	SLC30A8_uc010mcz.2_Missense_Mutation_p.S8Y|SLC30A8_uc011lia.1_Missense_Mutation_p.S8Y|SLC30A8_uc003yog.2_Missense_Mutation_p.S8Y	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	57	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CACAGTGGCTCCAAGCCCACA	0.507													74	159	---	---	---	---	PASS
WDR67	93594	broad.mit.edu	37	8	124140744	124140744	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124140744T>C	uc003ypp.1	+	14	2198	c.2108T>C	c.(2107-2109)TTA>TCA	p.L703S	WDR67_uc011lig.1_Missense_Mutation_p.L703S|WDR67_uc011lih.1_Missense_Mutation_p.L593S|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Intron|WDR67_uc003ypt.1_Missense_Mutation_p.L160S|WDR67_uc003ypu.1_Missense_Mutation_p.L160S	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	703						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TTGGATTACTTAAGAGAGAGG	0.259													13	108	---	---	---	---	PASS
KIAA0196	9897	broad.mit.edu	37	8	126073314	126073314	+	Intron	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:126073314G>A	uc003yrt.2	-						KIAA0196_uc011lir.1_Intron|KIAA0196_uc003yru.1_Intron	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin						cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTTAAAAAGCGTTTCCTTACC	0.378													13	66	---	---	---	---	PASS
ADCY8	114	broad.mit.edu	37	8	131797656	131797656	+	Silent	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:131797656G>C	uc003ytd.3	-	16	3382	c.3126C>G	c.(3124-3126)GCC>GCG	p.A1042A	ADCY8_uc010mds.2_Silent_p.A911A	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1042	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GGCCTGACACGGCCATGTAGG	0.498										HNSCC(32;0.087)			17	137	---	---	---	---	PASS
KCNQ3	3786	broad.mit.edu	37	8	133144504	133144504	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133144504G>T	uc003ytj.2	-	14	2032	c.1807C>A	c.(1807-1809)CCA>ACA	p.P603T	KCNQ3_uc010mdt.2_Missense_Mutation_p.P591T	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	603					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GCTACATATGGTTCATTCCTA	0.413													59	83	---	---	---	---	PASS
PTP4A3	11156	broad.mit.edu	37	8	142432440	142432440	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142432440A>C	uc003ywg.1	+	1	434	c.100A>C	c.(100-102)ATT>CTT	p.I34L	PTP4A3_uc003ywh.1_Missense_Mutation_p.I34L|PTP4A3_uc010met.1_Missense_Mutation_p.I34L	NM_032611	NP_116000	O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	34						early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			CAGCACCTTCATTGAGGTGAG	0.657													3	133	---	---	---	---	PASS
LYNX1	66004	broad.mit.edu	37	8	143846081	143846081	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143846081C>A	uc003yxb.2	-	5	965	c.338G>T	c.(337-339)GGC>GTC	p.G113V	LYNX1_uc003yxa.2_Missense_Mutation_p.G79V	NM_023946	NP_076435	Q9BZG9	LYNX1_HUMAN	Ly-6 neurotoxin-like protein 1 isoform a	Error:Variant_position_missing_in_Q9BZG9_after_alignment						anchored to membrane|plasma membrane					0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GGGGCCCAGGCCCAGGCTGGG	0.642													23	72	---	---	---	---	PASS
GPAA1	8733	broad.mit.edu	37	8	145138899	145138899	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145138899G>T	uc003zax.2	+	5	682	c.572G>T	c.(571-573)GGC>GTC	p.G191V	GPAA1_uc003zav.1_Missense_Mutation_p.G69V|GPAA1_uc003zaw.1_Missense_Mutation_p.G131V	NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	191	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GACCTTCTGGGCACTGAGGCT	0.562													16	125	---	---	---	---	PASS
KANK1	23189	broad.mit.edu	37	9	712600	712600	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:712600G>T	uc003zgl.1	+	7	2483	c.1834G>T	c.(1834-1836)GAC>TAC	p.D612Y	KANK1_uc003zgm.2_Missense_Mutation_p.D612Y|KANK1_uc003zgn.1_Missense_Mutation_p.D612Y|KANK1_uc003zgo.1_Missense_Mutation_p.D612Y|KANK1_uc003zgp.1_Missense_Mutation_p.D612Y|KANK1_uc003zgq.2_Missense_Mutation_p.D454Y|KANK1_uc003zgr.1_Missense_Mutation_p.D454Y|KANK1_uc003zgs.1_Missense_Mutation_p.D454Y	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	612					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GTCTGTGAACGACCTCACACT	0.507													30	28	---	---	---	---	PASS
KIAA1432	57589	broad.mit.edu	37	9	5763761	5763761	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5763761C>T	uc003zji.2	+	18	2590	c.2497C>T	c.(2497-2499)CTG>TTG	p.L833L	KIAA1432_uc003zjh.2_Silent_p.L833L|KIAA1432_uc003zjl.3_Silent_p.L796L|KIAA1432_uc003zjj.1_Silent_p.L375L	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	912						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CGAATATGCCCTGTGGAATTA	0.478													70	82	---	---	---	---	PASS
NOL6	65083	broad.mit.edu	37	9	33464075	33464075	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33464075C>T	uc003zsz.2	-	22	2965	c.2864G>A	c.(2863-2865)CGC>CAC	p.R955H	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_Missense_Mutation_p.R9H|NOL6_uc003zta.2_Intron|NOL6_uc010mjv.2_Missense_Mutation_p.R952H|NOL6_uc011lob.1_Missense_Mutation_p.R903H|NOL6_uc003ztb.1_Missense_Mutation_p.R955H	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	955					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AGAGTTTTTGCGGTCTTGGGG	0.567													4	166	---	---	---	---	PASS
DNAI1	27019	broad.mit.edu	37	9	34500842	34500842	+	Intron	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34500842G>A	uc003zum.2	+							NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1						cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		CTGCTGGTAAGTATAGGCATT	0.547									Kartagener_syndrome		OREG0019152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	65	---	---	---	---	PASS
TPM2	7169	broad.mit.edu	37	9	35685691	35685691	+	Silent	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35685691G>C	uc003zxq.2	-	3	566	c.327C>G	c.(325-327)GCC>GCG	p.A109A	TPM2_uc003zxr.2_Silent_p.A109A|TPM2_uc003zxs.2_Silent_p.A109A|TPM2_uc010mkz.2_Silent_p.A109A|TPM2_uc011lpa.1_Silent_p.A109A	NM_213674	NP_998839	P07951	TPM2_HUMAN	tropomyosin 2 (beta) isoform 2	109	By similarity.				muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle			ovary(1)	1	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCTTCTGCAGGGCTGTAGCCA	0.672													137	67	---	---	---	---	PASS
FRMPD1	22844	broad.mit.edu	37	9	37746351	37746351	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37746351G>A	uc004aag.1	+	16	4366	c.4322G>A	c.(4321-4323)GGG>GAG	p.G1441E	FRMPD1_uc004aah.1_Missense_Mutation_p.G1441E	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1441						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		ACTTCCTGGGGGGTTGGAAAC	0.572													14	27	---	---	---	---	PASS
TMC1	117531	broad.mit.edu	37	9	75407166	75407166	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75407166G>A	uc004aiz.1	+	17	2004	c.1464G>A	c.(1462-1464)AAG>AAA	p.K488K	TMC1_uc010moz.1_Silent_p.K446K|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Silent_p.K342K|TMC1_uc010mpa.1_Silent_p.K342K	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	488	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						ATATGATCAAGGCCTACAATG	0.428													151	304	---	---	---	---	PASS
TRPM6	140803	broad.mit.edu	37	9	77418743	77418743	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77418743C>A	uc004ajl.1	-	15	1936	c.1698G>T	c.(1696-1698)CAG>CAT	p.Q566H	TRPM6_uc004ajk.1_Missense_Mutation_p.Q561H|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_5'Flank	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	566	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TTCTAATGAACTGGGAGTGCA	0.423													108	209	---	---	---	---	PASS
GNA14	9630	broad.mit.edu	37	9	80040466	80040466	+	Intron	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:80040466A>G	uc004aku.2	-							NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14						activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						TGTCCACAAGATAGACACTTA	0.443													43	94	---	---	---	---	PASS
TLE1	7088	broad.mit.edu	37	9	84199166	84199166	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:84199166T>C	uc004aly.2	-	20	2701	c.2260A>G	c.(2260-2262)ATA>GTA	p.I754V	TLE1_uc004alz.2_Missense_Mutation_p.I764V|TLE1_uc011lsr.1_Missense_Mutation_p.I739V	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	754	WD 6.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						CCAGTGACTATGTACTTATCA	0.413													34	95	---	---	---	---	PASS
RASEF	158158	broad.mit.edu	37	9	85615852	85615852	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:85615852C>T	uc004amo.1	-	10	1657	c.1396G>A	c.(1396-1398)GGG>AGG	p.G466R		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	466					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						TCCTGCACCCCGTGTGACCTC	0.502													33	76	---	---	---	---	PASS
C9orf79	286234	broad.mit.edu	37	9	90501370	90501370	+	Silent	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90501370T>A	uc004app.3	+	4	2003	c.1968T>A	c.(1966-1968)CCT>CCA	p.P656P	C9orf79_uc004apo.1_Silent_p.P468P	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	656						integral to membrane				ovary(3)	3						TGCTACAGCCTGATGGGGAAT	0.622													21	51	---	---	---	---	PASS
NXNL2	158046	broad.mit.edu	37	9	91150497	91150497	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91150497G>C	uc011ltj.1	+	1	482	c.148G>C	c.(148-150)GAC>CAC	p.D50H	NXNL2_uc004aqa.2_Missense_Mutation_p.D50H	NM_001161625	NP_001155097	Q5VZ03	NXNL2_HUMAN	nucleoredoxin-like 2 isoform 1	50	Thioredoxin.										0						GCTGCTCTGCGACTTCTATAC	0.697													2	6	---	---	---	---	PASS
SECISBP2	79048	broad.mit.edu	37	9	91940430	91940430	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91940430G>T	uc004aqj.1	+	3	351	c.271G>T	c.(271-273)GCC>TCC	p.A91S	SECISBP2_uc010mqn.1_Missense_Mutation_p.A91S|SECISBP2_uc004aqi.1_Intron|SECISBP2_uc011ltk.1_Missense_Mutation_p.A91S|SECISBP2_uc004aqk.1_Intron|SECISBP2_uc010mqo.1_5'UTR|SECISBP2_uc011ltl.1_Missense_Mutation_p.A23S	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	91					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						TCATCCATATGCCTATTCTCC	0.398													106	235	---	---	---	---	PASS
MRPL50	54534	broad.mit.edu	37	9	104152739	104152739	+	3'UTR	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:104152739C>A	uc004bbe.2	-	2					MRPL50_uc011lvj.1_Intron	NM_019051	NP_061924	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50							mitochondrion|ribosome					0		Acute lymphoblastic leukemia(62;0.0559)				TGTTTCTCTTCCGAATTGCTT	0.388													12	175	---	---	---	---	PASS
ZNF189	7743	broad.mit.edu	37	9	104170972	104170972	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:104170972A>G	uc004bbh.1	+	3	1198	c.922A>G	c.(922-924)AGA>GGA	p.R308G	ZNF189_uc004bbg.1_Missense_Mutation_p.R266G|ZNF189_uc004bbi.1_Missense_Mutation_p.R294G|ZNF189_uc011lvk.1_Missense_Mutation_p.R293G	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	308	C2H2-type 6.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				TGAGCATCAAAGAATTCACAC	0.398													76	182	---	---	---	---	PASS
SLC44A1	23446	broad.mit.edu	37	9	108128711	108128711	+	Splice_Site	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:108128711G>T	uc004bcn.2	+	12	1715	c.1494_splice	c.e12+1	p.Q498_splice	SLC44A1_uc010mtk.1_Splice_Site_p.Q498_splice|SLC44A1_uc004bco.1_Splice_Site_p.Q290_splice	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen							integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	TTTAAATCAGGtaaaatattt	0.299													19	48	---	---	---	---	PASS
SUSD1	64420	broad.mit.edu	37	9	114825260	114825260	+	Missense_Mutation	SNP	G	T	T	rs141503818	byFrequency	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114825260G>T	uc004bfu.2	-	13	1848	c.1807C>A	c.(1807-1809)CGC>AGC	p.R603S	SUSD1_uc010mui.2_Missense_Mutation_p.R603S|SUSD1_uc010muj.2_Missense_Mutation_p.R603S	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	603	Extracellular (Potential).					integral to membrane	calcium ion binding				0						AGTCTGAGGCGTGGTAGAGGT	0.478													62	146	---	---	---	---	PASS
BSPRY	54836	broad.mit.edu	37	9	116116564	116116564	+	Silent	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116116564T>A	uc004bhg.3	+	2	294	c.246T>A	c.(244-246)GCT>GCA	p.A82A	BSPRY_uc010muw.2_Silent_p.A82A	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	82					calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						TACAGAGTGCTGCCATCACCA	0.393													4	95	---	---	---	---	PASS
WDR38	401551	broad.mit.edu	37	9	127619793	127619793	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127619793G>A	uc004box.2	+	9	885	c.829G>A	c.(829-831)GTG>ATG	p.V277M	WDR38_uc011lzn.1_Missense_Mutation_p.V267M|WDR38_uc011lzo.1_Missense_Mutation_p.V278M|WDR38_uc011lzp.1_Missense_Mutation_p.V229M	NM_001045476	NP_001038941	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	277	WD 7.										0						AGTCCTGGATGTGGCCCACAC	0.572													36	84	---	---	---	---	PASS
C9orf119	375757	broad.mit.edu	37	9	131038466	131038466	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131038466A>T	uc004bup.2	+	1	42	c.42A>T	c.(40-42)AAA>AAT	p.K14N	GOLGA2_uc011maw.1_5'Flank|GOLGA2_uc010mxw.2_5'Flank|GOLGA2_uc004bul.1_5'Flank|C9orf119_uc010mxx.1_Missense_Mutation_p.K14N	NM_001040011	NP_001035100	Q1ZZU3	SWI5_HUMAN	hypothetical protein LOC375757	14					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0						GTCACAACAAAAGCTGCGCAC	0.632													31	72	---	---	---	---	PASS
C9orf98	158067	broad.mit.edu	37	9	135601245	135601245	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135601245C>A	uc004cbu.1	-	13	1826	c.1270G>T	c.(1270-1272)GAT>TAT	p.D424Y	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Missense_Mutation_p.D220Y	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	424	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		TCTTCAGCATCCTTTGGGTTC	0.552													6	13	---	---	---	---	PASS
SEC16A	9919	broad.mit.edu	37	9	139369100	139369100	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139369100T>C	uc004chx.2	-	3	3277	c.2968A>G	c.(2968-2970)ACT>GCT	p.T990A	SEC16A_uc004chv.3_Intron|SEC16A_uc004chw.2_Missense_Mutation_p.T990A|SEC16A_uc010nbn.2_Missense_Mutation_p.T990A|SEC16A_uc010nbo.1_Missense_Mutation_p.T990A	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	812					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GCTCCGTAAGTGTCTTCCTGA	0.502													20	22	---	---	---	---	PASS
MCM10	55388	broad.mit.edu	37	10	13222487	13222487	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13222487C>A	uc001ima.2	+	7	914	c.813C>A	c.(811-813)GGC>GGA	p.G271G	MCM10_uc001imb.2_Silent_p.G270G|MCM10_uc001imc.2_Silent_p.G270G	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	271					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						AAATGACCGGCCGAAAACTGA	0.413													38	45	---	---	---	---	PASS
ITGA8	8516	broad.mit.edu	37	10	15686082	15686082	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15686082C>A	uc001ioc.1	-	13	1346	c.1346G>T	c.(1345-1347)GGA>GTA	p.G449V	ITGA8_uc010qcb.1_Missense_Mutation_p.G434V	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	449	Extracellular (Potential).|FG-GAP 7.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						AAAGCCAAATCCGGAAGGGAC	0.438													30	50	---	---	---	---	PASS
VIM	7431	broad.mit.edu	37	10	17277176	17277176	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17277176C>A	uc001iou.2	+	7	1430	c.1017C>A	c.(1015-1017)TCC>TCA	p.S339S	VIM_uc001iov.1_Silent_p.S339S|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Silent_p.S339S|VIM_uc001ioy.1_Intron|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Silent_p.S297S|VIM_uc001ipc.1_Silent_p.S339S	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	339	Rod.|Coil 2.			S -> C (in Ref. 17; AAA61281).	cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						AGAATGAGTCCCTGGAACGCC	0.458													16	37	---	---	---	---	PASS
PIP4K2A	5305	broad.mit.edu	37	10	22830743	22830743	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:22830743C>A	uc001irl.3	-	8	1274	c.1026G>T	c.(1024-1026)AAG>AAT	p.K342N	PIP4K2A_uc010qcu.1_Missense_Mutation_p.K202N	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	342	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						TTTCATGGCACTTAATTCCAT	0.507													40	74	---	---	---	---	PASS
ARMC3	219681	broad.mit.edu	37	10	23248058	23248058	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:23248058G>C	uc001irm.3	+	5	435	c.352G>C	c.(352-354)GCT>CCT	p.A118P	ARMC3_uc010qcv.1_Missense_Mutation_p.A118P|ARMC3_uc010qcw.1_5'UTR|ARMC3_uc001irn.1_Missense_Mutation_p.A30P	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	118	ARM 3.						binding				0						TGCCCAGCTCGCTCCAGAAGG	0.289													23	173	---	---	---	---	PASS
ANKRD30A	91074	broad.mit.edu	37	10	37421233	37421233	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:37421233G>A	uc001iza.1	+	4	507	c.408G>A	c.(406-408)CTG>CTA	p.L136L		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	192	ANK 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AATTTTTGCTGATAAAAAATG	0.289													9	122	---	---	---	---	PASS
TMEM72	643236	broad.mit.edu	37	10	45429098	45429098	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45429098T>A	uc001jbn.2	+	4	420	c.223T>A	c.(223-225)TCC>ACC	p.S75T	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_5'UTR	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	75						integral to membrane					0						TCAACCAGGGTCCCTGGCAGA	0.612													8	58	---	---	---	---	PASS
DRGX	644168	broad.mit.edu	37	10	50574253	50574253	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50574253G>A	uc010qgq.1	-	6	715	c.715C>T	c.(715-717)CCC>TCC	p.P239S		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	239					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ACAGGGCCGGGGCTGCTGCTG	0.652													12	25	---	---	---	---	PASS
PCDH15	65217	broad.mit.edu	37	10	55582895	55582895	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:55582895C>A	uc001jju.1	-	33	4986	c.4591G>T	c.(4591-4593)GAA>TAA	p.E1531*	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Nonsense_Mutation_p.E1528*|PCDH15_uc010qhw.1_Nonsense_Mutation_p.E1491*|PCDH15_uc010qhx.1_Nonsense_Mutation_p.E1462*|PCDH15_uc010qhy.1_Nonsense_Mutation_p.E1538*|PCDH15_uc010qhz.1_Nonsense_Mutation_p.E1533*|PCDH15_uc010qia.1_Nonsense_Mutation_p.E1511*|PCDH15_uc010qib.1_Nonsense_Mutation_p.E1508*	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1531	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTTATGTTTTCCTTATAAAGG	0.368										HNSCC(58;0.16)			44	94	---	---	---	---	PASS
PCDH15	65217	broad.mit.edu	37	10	55582896	55582896	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:55582896C>A	uc001jju.1	-	33	4985	c.4590G>T	c.(4588-4590)AAG>AAT	p.K1530N	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.K1527N|PCDH15_uc010qhw.1_Missense_Mutation_p.K1490N|PCDH15_uc010qhx.1_Missense_Mutation_p.K1461N|PCDH15_uc010qhy.1_Missense_Mutation_p.K1537N|PCDH15_uc010qhz.1_Missense_Mutation_p.K1532N|PCDH15_uc010qia.1_Missense_Mutation_p.K1510N|PCDH15_uc010qib.1_Missense_Mutation_p.K1507N	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1530	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTATGTTTTCCTTATAAAGGG	0.363										HNSCC(58;0.16)			42	97	---	---	---	---	PASS
PCDH15	65217	broad.mit.edu	37	10	55782699	55782699	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:55782699G>T	uc001jju.1	-	19	2874	c.2479C>A	c.(2479-2481)CTT>ATT	p.L827I	PCDH15_uc010qhq.1_Missense_Mutation_p.L832I|PCDH15_uc010qhr.1_Missense_Mutation_p.L827I|PCDH15_uc010qhs.1_Missense_Mutation_p.L839I|PCDH15_uc010qht.1_Missense_Mutation_p.L834I|PCDH15_uc010qhu.1_Missense_Mutation_p.L827I|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.L827I|PCDH15_uc010qhw.1_Missense_Mutation_p.L790I|PCDH15_uc010qhx.1_Missense_Mutation_p.L756I|PCDH15_uc010qhy.1_Missense_Mutation_p.L832I|PCDH15_uc010qhz.1_Missense_Mutation_p.L827I|PCDH15_uc010qia.1_Missense_Mutation_p.L805I|PCDH15_uc010qib.1_Missense_Mutation_p.L805I|PCDH15_uc001jjw.2_Missense_Mutation_p.L827I	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	827	Extracellular (Potential).|Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCTTCAACAAGGACAGTGTAT	0.413										HNSCC(58;0.16)			19	129	---	---	---	---	PASS
FAM13C	220965	broad.mit.edu	37	10	61022354	61022354	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61022354G>C	uc001jkn.2	-	11	1210	c.1076C>G	c.(1075-1077)CCT>CGT	p.P359R	FAM13C_uc001jko.2_Intron|FAM13C_uc010qid.1_Missense_Mutation_p.P276R|FAM13C_uc010qie.1_Missense_Mutation_p.P276R|FAM13C_uc010qif.1_Missense_Mutation_p.P381R|FAM13C_uc001jkp.2_Missense_Mutation_p.P276R	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	359										ovary(2)	2						CAGGTTTCTAGGTGGACCTTT	0.493													36	89	---	---	---	---	PASS
ANK3	288	broad.mit.edu	37	10	61830138	61830138	+	Nonsense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61830138G>A	uc001jky.2	-	37	10693	c.10501C>T	c.(10501-10503)CAG>TAG	p.Q3501*	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3501					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTGAAGAACTGGGCCCCTGAC	0.448													46	86	---	---	---	---	PASS
TMEM26	219623	broad.mit.edu	37	10	63195965	63195965	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:63195965G>A	uc001jlo.2	-	2	602	c.233C>T	c.(232-234)CCA>CTA	p.P78L	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlq.2_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	78	Helical; (Potential).					integral to membrane					0	Prostate(12;0.0112)					CCATAATGATGGAACGATGCT	0.333													11	38	---	---	---	---	PASS
CTNNA3	29119	broad.mit.edu	37	10	67726488	67726488	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:67726488C>A	uc009xpn.1	-	17	2405	c.2282G>T	c.(2281-2283)TGT>TTT	p.C761F	CTNNA3_uc001jmw.2_Missense_Mutation_p.C761F	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	761					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						GTCCTGTTTACAAGATGGATC	0.383													33	121	---	---	---	---	PASS
MYPN	84665	broad.mit.edu	37	10	69881321	69881321	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69881321C>T	uc001jnm.3	+	3	311	c.126C>T	c.(124-126)TGC>TGT	p.C42C	MYPN_uc001jnl.1_Silent_p.C42C|MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_Silent_p.C42C|MYPN_uc001jnp.1_Silent_p.C42C|MYPN_uc009xps.2_Silent_p.C42C|MYPN_uc009xpt.2_Silent_p.C42C|MYPN_uc010qit.1_5'UTR|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	42	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CCAACCCTTGCCATTTCGGCA	0.517													93	90	---	---	---	---	PASS
MYPN	84665	broad.mit.edu	37	10	69961674	69961674	+	Silent	SNP	C	T	T	rs139820597	byFrequency	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69961674C>T	uc001jnm.3	+	19	3767	c.3582C>T	c.(3580-3582)CGC>CGT	p.R1194R	MYPN_uc001jnn.3_Silent_p.R919R|MYPN_uc001jno.3_Silent_p.R1194R|MYPN_uc009xpt.2_Silent_p.R1194R|MYPN_uc010qit.1_Silent_p.R900R|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	1194	Interaction with ACTN.|Ig-like 5.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TGGAGTGCCGCGTGATAGGCA	0.547													68	287	---	---	---	---	PASS
KIAA1279	26128	broad.mit.edu	37	10	70775952	70775952	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70775952G>T	uc001joy.2	+	7	1742	c.1646G>T	c.(1645-1647)CGA>CTA	p.R549L		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	549					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						GCTAAGTTTCGAGTTGCCCGT	0.413													58	213	---	---	---	---	PASS
NEUROG3	50674	broad.mit.edu	37	10	71332486	71332486	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71332486G>C	uc001jpp.2	-	2	472	c.314C>G	c.(313-315)GCC>GGC	p.A105G		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	105	Helix-loop-helix motif.				central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						ACCGCGCAGGGCGTCCAGTGC	0.617													21	66	---	---	---	---	PASS
TNKS2	80351	broad.mit.edu	37	10	93572875	93572875	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93572875G>A	uc001khp.2	+	2	632	c.335G>A	c.(334-336)CGA>CAA	p.R112Q		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	112	ANK 2.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				CTCCTTTTGCGACATGGTGCA	0.428													4	95	---	---	---	---	PASS
OPALIN	93377	broad.mit.edu	37	10	98109555	98109555	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98109555G>T	uc001kmj.2	-	4	540	c.101C>A	c.(100-102)GCG>GAG	p.A34E	OPALIN_uc010qor.1_Missense_Mutation_p.A24E|OPALIN_uc001kmi.2_Missense_Mutation_p.A24E|OPALIN_uc001kmk.2_Missense_Mutation_p.A11E|OPALIN_uc010qos.1_RNA	NM_033207	NP_149984	Q96PE5	OPALI_HUMAN	transmembrane protein 10 isoform a	34	Helical; (Potential).					Golgi apparatus|integral to membrane|plasma membrane					0						TGGTATGCCCGCCGCTAATCC	0.478													20	8	---	---	---	---	PASS
PAX2	5076	broad.mit.edu	37	10	102568959	102568959	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102568959C>A	uc001krk.3	+	8	1504	c.954C>A	c.(952-954)AAC>AAA	p.N318K	PAX2_uc001krl.3_Missense_Mutation_p.N295K|PAX2_uc001krm.3_Missense_Mutation_p.N318K|PAX2_uc001kro.3_Missense_Mutation_p.N295K|PAX2_uc001krn.3_Missense_Mutation_p.N295K|PAX2_uc010qps.1_Missense_Mutation_p.N294K|PAX2_uc001krp.1_Missense_Mutation_p.N291K	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	318					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		TGGGCAGCAACGTGTCAGGCA	0.607													33	61	---	---	---	---	PASS
SMC3	9126	broad.mit.edu	37	10	112360876	112360876	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112360876G>T	uc001kze.2	+	23	2758	c.2632G>T	c.(2632-2634)GCA>TCA	p.A878S		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	878	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		AGACACTATGGCACGATCAGA	0.353													65	88	---	---	---	---	PASS
RAB11FIP2	22841	broad.mit.edu	37	10	119798954	119798954	+	Intron	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:119798954A>C	uc001ldj.1	-						RAB11FIP2_uc009xyz.1_Intron	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2						protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		GAGACTTCCTACAAACAATTT	0.368													36	32	---	---	---	---	PASS
WDR11	55717	broad.mit.edu	37	10	122659586	122659586	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:122659586C>A	uc010qtf.1	+	20	2799	c.2561C>A	c.(2560-2562)GCC>GAC	p.A854D	WDR11_uc010qte.1_Missense_Mutation_p.A456D|WDR11_uc001lfd.1_Missense_Mutation_p.A372D|WDR11_uc009xzn.2_Missense_Mutation_p.A145D	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	854						integral to membrane					0						GCCTCTCTTGCCTTGAAAGCC	0.363													5	127	---	---	---	---	PASS
C10orf90	118611	broad.mit.edu	37	10	128114630	128114630	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128114630T>A	uc001ljq.2	-	8	2112	c.1991A>T	c.(1990-1992)AAG>ATG	p.K664M	C10orf90_uc001ljp.2_Missense_Mutation_p.K520M|C10orf90_uc010qum.1_Missense_Mutation_p.K761M|C10orf90_uc001ljo.2_RNA	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	664										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TTCTTTTTTCTTTTTAACTTC	0.448													66	55	---	---	---	---	PASS
MUC2	4583	broad.mit.edu	37	11	1085941	1085941	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1085941G>A	uc001lsx.1	+	22	2808	c.2781G>A	c.(2779-2781)ACG>ACA	p.T927T		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	927	VWFD 3.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGCAGAGGACGGAGCTGAAGT	0.652													14	30	---	---	---	---	PASS
MUC5B	727897	broad.mit.edu	37	11	1264913	1264913	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1264913C>A	uc009ycr.1	+	48	8843	c.8717C>A	c.(8716-8718)CCA>CAA	p.P2906Q	MUC5B_uc001ltb.2_Missense_Mutation_p.P2271Q	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2268	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCCCTTCTCCAGGGACGACC	0.682													32	140	---	---	---	---	PASS
HBG2	3048	broad.mit.edu	37	11	5274532	5274532	+	Intron	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5274532C>G	uc001mai.1	-						HBG2_uc001maj.1_Missense_Mutation_p.S140T	NM_000559	NP_000550	P69892	HBG2_HUMAN	A-gamma globin						blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGACAGGGCACTGGCCACTCC	0.493													28	52	---	---	---	---	PASS
HBE1	3046	broad.mit.edu	37	11	5289722	5289722	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5289722C>A	uc001mal.1	-	3	674	c.421G>T	c.(421-423)GCC>TCC	p.A141S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Missense_Mutation_p.A141S	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin	141					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGCCAGGGCAATGGCGACA	0.557													66	138	---	---	---	---	PASS
OR51I2	390064	broad.mit.edu	37	11	5475566	5475566	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5475566T>A	uc010qzf.1	+	1	848	c.848T>A	c.(847-849)GTG>GAG	p.V283E	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACCTATTTGTGCCTCCTGTG	0.463													67	162	---	---	---	---	PASS
DCHS1	8642	broad.mit.edu	37	11	6648620	6648620	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6648620C>G	uc001mem.1	-	14	6060	c.5650G>C	c.(5650-5652)GCT>CCT	p.A1884P		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1884	Cadherin 18.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTAGCTCCAGCATCAGGGTCA	0.627													8	13	---	---	---	---	PASS
OR10A2	341276	broad.mit.edu	37	11	6891618	6891618	+	Silent	SNP	C	A	A	rs61737577		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6891618C>A	uc001meu.1	+	1	633	c.633C>A	c.(631-633)GCC>GCA	p.A211A		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	211	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TTGCTGCTGCCATCCTCAAGA	0.448													70	198	---	---	---	---	PASS
NLRP14	338323	broad.mit.edu	37	11	7064725	7064725	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7064725A>G	uc001mfb.1	+	4	1791	c.1468A>G	c.(1468-1470)ATG>GTG	p.M490V		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	490	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TTTTGCAGCTATGTTCTATAT	0.408													38	102	---	---	---	---	PASS
ABCC8	6833	broad.mit.edu	37	11	17427074	17427074	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17427074G>T	uc001mnc.2	-	27	3492	c.3366C>A	c.(3364-3366)AAC>AAA	p.N1122K		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1122	Cytoplasmic (By similarity).|ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ATGAAAATCTGTTCAGGATGC	0.512													60	131	---	---	---	---	PASS
SPTY2D1	144108	broad.mit.edu	37	11	18636920	18636920	+	Missense_Mutation	SNP	G	A	A	rs138155181	byFrequency	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18636920G>A	uc001moy.2	-	3	1117	c.901C>T	c.(901-903)CGT>TGT	p.R301C	SPTY2D1_uc010rdi.1_Missense_Mutation_p.R301C	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	301	Ser-rich.									breast(1)	1						TGGCCCTCACGAAGTGAGGGT	0.507													9	163	---	---	---	---	PASS
ANO3	63982	broad.mit.edu	37	11	26663521	26663521	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:26663521T>C	uc001mqt.3	+	22	2365	c.2220T>C	c.(2218-2220)GAT>GAC	p.D740D	ANO3_uc010rdr.1_Silent_p.D724D|ANO3_uc010rds.1_Silent_p.D579D|ANO3_uc010rdt.1_Silent_p.D594D	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	740	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGGAAAATGATTGGAATCTGC	0.433													43	113	---	---	---	---	PASS
KCNA4	3739	broad.mit.edu	37	11	30032759	30032759	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:30032759G>T	uc001msk.2	-	2	2619	c.1467C>A	c.(1465-1467)GTC>GTA	p.V489V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	489	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAAAGAGGATGACCCCAATGA	0.527													22	71	---	---	---	---	PASS
LRRC4C	57689	broad.mit.edu	37	11	40137001	40137001	+	Nonsense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:40137001A>T	uc001mxa.1	-	2	2806	c.842T>A	c.(841-843)TTA>TAA	p.L281*	LRRC4C_uc001mxc.1_Nonsense_Mutation_p.L277*|LRRC4C_uc001mxd.1_Nonsense_Mutation_p.L277*|LRRC4C_uc001mxb.1_Nonsense_Mutation_p.L277*	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	281	LRR 9.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				ATGAGGCAGTAATGTTAGATT	0.453													58	140	---	---	---	---	PASS
OR4C16	219428	broad.mit.edu	37	11	55340461	55340461	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55340461G>T	uc010rih.1	+	1	858	c.858G>T	c.(856-858)ACG>ACT	p.T286T		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TGATTTACACGCTGAAGAATA	0.363													14	67	---	---	---	---	PASS
OR8H2	390151	broad.mit.edu	37	11	55872536	55872536	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55872536T>C	uc010riy.1	+	1	18	c.18T>C	c.(16-18)AAT>AAC	p.N6N		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					GTAGAAGGAATAACACAAATG	0.343										HNSCC(53;0.14)			6	232	---	---	---	---	PASS
OR8J3	81168	broad.mit.edu	37	11	55904850	55904850	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55904850C>A	uc010riz.1	-	1	345	c.345G>T	c.(343-345)CTG>CTT	p.L115L		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					CCATCACAGCCAGCATCATTA	0.483													56	119	---	---	---	---	PASS
OR8J1	219477	broad.mit.edu	37	11	56127763	56127763	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56127763T>A	uc010rjh.1	+	1	41	c.41T>A	c.(40-42)CTT>CAT	p.L14H		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAGTTTATTCTTACAGGTGTC	0.458													29	76	---	---	---	---	PASS
OR5M9	390162	broad.mit.edu	37	11	56230176	56230176	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56230176C>G	uc010rjj.1	-	1	702	c.702G>C	c.(700-702)AAG>AAC	p.K234N		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TGGAGAACGCCTTCCTCCTGC	0.522													12	16	---	---	---	---	PASS
OR9G4	283189	broad.mit.edu	37	11	56510333	56510333	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56510333C>A	uc010rjo.1	-	1	955	c.955G>T	c.(955-957)GCA>TCA	p.A319S		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	319	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GTCTGTGTTGCTTTCCTGAAG	0.393													46	130	---	---	---	---	PASS
P2RX3	5024	broad.mit.edu	37	11	57106060	57106060	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57106060C>A	uc001nju.2	+	1	112	c.36C>A	c.(34-36)ACC>ACA	p.T12T	SSRP1_uc001njt.2_5'Flank	NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	12	Cytoplasmic (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						CCTATGAGACCACCAAGTCGG	0.542													96	226	---	---	---	---	PASS
OR5B17	219965	broad.mit.edu	37	11	58126131	58126131	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58126131C>A	uc010rke.1	-	1	412	c.412G>T	c.(412-414)GTG>TTG	p.V138L		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	138	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CAAGCACACACACGTGTTGTC	0.453													17	56	---	---	---	---	PASS
OR5B2	390190	broad.mit.edu	37	11	58190356	58190356	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58190356G>T	uc010rkg.1	-	1	379	c.379C>A	c.(379-381)CCC>ACC	p.P127T		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TAGTGTAGGGGTTTGCACACT	0.522													14	53	---	---	---	---	PASS
MS4A14	84689	broad.mit.edu	37	11	60183926	60183926	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60183926G>T	uc001npj.2	+	5	2050	c.1485G>T	c.(1483-1485)TTG>TTT	p.L495F	MS4A14_uc001npi.2_Missense_Mutation_p.L383F|MS4A14_uc001npn.2_Missense_Mutation_p.L233F|MS4A14_uc001npk.2_Missense_Mutation_p.L478F|MS4A14_uc001npl.2_Missense_Mutation_p.L233F|MS4A14_uc001npm.2_Missense_Mutation_p.L233F	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	495	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						CCAAAGCCTTGCAATACTTAA	0.433													43	95	---	---	---	---	PASS
DDB1	1642	broad.mit.edu	37	11	61071505	61071505	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61071505C>T	uc001nrc.3	-	22	2890	c.2664G>A	c.(2662-2664)GTG>GTA	p.V888V	DDB1_uc010rle.1_Silent_p.V199V|DDB1_uc010rlf.1_Silent_p.V888V	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	888	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CATAGAGCCGCACCTGGGAAG	0.547								NER					27	72	---	---	---	---	PASS
SPDYC	387778	broad.mit.edu	37	11	64939436	64939436	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64939436C>T	uc010rnz.1	+	3	222	c.222C>T	c.(220-222)TTC>TTT	p.F74F		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	74	Speedy/Ringo box; Required for CDK- binding (By similarity).				cell cycle	nucleus	protein kinase binding				0						TCCAGGAATTCCTCTCCAAAG	0.527													36	74	---	---	---	---	PASS
SPDYC	387778	broad.mit.edu	37	11	64940209	64940209	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64940209C>G	uc010rnz.1	+	6	571	c.571C>G	c.(571-573)CAT>GAT	p.H191D		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	191					cell cycle	nucleus	protein kinase binding				0						GCGCCCCCACCATGGTGGGGT	0.662													24	57	---	---	---	---	PASS
MALAT1	378938	broad.mit.edu	37	11	65267822	65267822	+	RNA	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65267822A>C	uc010roh.1	+	1		c.2590A>C			uc001ody.2_RNA|MALAT1_uc001odz.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						TTGAGTTAAGATTATTTTTTA	0.368													19	41	---	---	---	---	PASS
MAP3K11	4296	broad.mit.edu	37	11	65375242	65375242	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65375242A>G	uc001oew.2	-	4	1608	c.1115T>C	c.(1114-1116)ATC>ACC	p.I372T	MAP3K11_uc001oev.2_5'Flank|MAP3K11_uc010rol.1_Missense_Mutation_p.I115T|MAP3K11_uc001oex.1_Intron	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	372	Protein kinase.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						CTGCTGCAGGATGGAGGCGAA	0.652													30	48	---	---	---	---	PASS
LRP5	4041	broad.mit.edu	37	11	68216404	68216404	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68216404C>A	uc001ont.2	+	23	4789	c.4714C>A	c.(4714-4716)CCC>ACC	p.P1572T	LRP5_uc009ysg.2_Missense_Mutation_p.P982T	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1572	Pro-rich.|Cytoplasmic (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GGACTCAGACCCCTATCCACC	0.657													22	33	---	---	---	---	PASS
KRTAP5-11	440051	broad.mit.edu	37	11	71293713	71293713	+	Nonsense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71293713A>T	uc001oqu.2	-	1	209	c.171T>A	c.(169-171)TGT>TGA	p.C57*		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	57	6 X 4 AA repeats of C-C-X-P.					keratin filament					0						CACAGGAGCCACAGCTGGAGC	0.627													61	167	---	---	---	---	PASS
ARHGEF17	9828	broad.mit.edu	37	11	73022174	73022174	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73022174C>T	uc001otu.2	+	1	2512	c.2491C>T	c.(2491-2493)CCC>TCC	p.P831S		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	831					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CCTGAGTGACCCCAGCCGCCG	0.642													21	72	---	---	---	---	PASS
MYO7A	4647	broad.mit.edu	37	11	76869394	76869394	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:76869394G>T	uc001oyb.2	+	9	1193	c.921G>T	c.(919-921)GTG>GTT	p.V307V	MYO7A_uc010rsl.1_Silent_p.V307V|MYO7A_uc010rsm.1_Silent_p.V296V|MYO7A_uc001oyc.2_Silent_p.V307V	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	307	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCATGAAGGTGCTCATGTTCA	0.617													16	34	---	---	---	---	PASS
GRM5	2915	broad.mit.edu	37	11	88386499	88386499	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:88386499C>T	uc001pcq.2	-	3	1184	c.984G>A	c.(982-984)AAG>AAA	p.K328K	GRM5_uc009yvm.2_Silent_p.K328K	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	328	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GAGATTGGAGCTTGATTGTGA	0.463													17	77	---	---	---	---	PASS
TYR	7299	broad.mit.edu	37	11	88911881	88911881	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:88911881G>A	uc001pcs.2	+	1	842	c.760G>A	c.(760-762)GGT>AGT	p.G254S		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	254	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	GTACATGGGAGGTCAGCACCC	0.458									Oculocutaneous_Albinism				18	120	---	---	---	---	PASS
FAT3	120114	broad.mit.edu	37	11	92085270	92085270	+	5'UTR	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92085270T>C	uc001pdj.3	+	1						NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3						homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGATGGAAGTATGATGTGAT	0.453										TCGA Ovarian(4;0.039)			24	32	---	---	---	---	PASS
FAT3	120114	broad.mit.edu	37	11	92532543	92532543	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92532543G>C	uc001pdj.3	+	9	6381	c.6364G>C	c.(6364-6366)GTC>CTC	p.V2122L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2122	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGTGACCTATGTCCTGCAGGA	0.423										TCGA Ovarian(4;0.039)			3	27	---	---	---	---	PASS
CCDC67	159989	broad.mit.edu	37	11	93065417	93065417	+	5'UTR	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93065417T>A	uc001pdq.2	+	2					CCDC67_uc001pdo.1_5'UTR|CCDC67_uc001pdp.2_5'UTR	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67											ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				GATGTAGCAGTTTCTTGACAT	0.323													10	16	---	---	---	---	PASS
ANKRD49	54851	broad.mit.edu	37	11	94231407	94231407	+	Silent	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94231407G>C	uc001pew.2	+	3	568	c.429G>C	c.(427-429)ACG>ACC	p.T143T	ANKRD49_uc001pex.2_3'UTR|ANKRD49_uc001pey.2_RNA	NM_017704	NP_060174	Q8WVL7	ANR49_HUMAN	fetal globin inducing factor	143	ANK 3.				positive regulation of transcription, DNA-dependent					central_nervous_system(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ATGGCTGGACGCCCCTGCACA	0.507													8	86	---	---	---	---	PASS
ANKRD49	54851	broad.mit.edu	37	11	94231411	94231411	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94231411C>T	uc001pew.2	+	3	572	c.433C>T	c.(433-435)CTG>TTG	p.L145L	ANKRD49_uc001pex.2_3'UTR|ANKRD49_uc001pey.2_RNA	NM_017704	NP_060174	Q8WVL7	ANR49_HUMAN	fetal globin inducing factor	145	ANK 3.				positive regulation of transcription, DNA-dependent					central_nervous_system(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CTGGACGCCCCTGCACAGTGC	0.498													7	86	---	---	---	---	PASS
TMEM123	114908	broad.mit.edu	37	11	102272392	102272392	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102272392T>C	uc001pha.2	-	4	901	c.480A>G	c.(478-480)AAA>AAG	p.K160K	TMEM123_uc009yxc.2_Silent_p.K141K	NM_052932	NP_443164	Q8N131	PORIM_HUMAN	transmembrane protein 123 precursor	160	Extracellular (Potential).				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(2)	2	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		ATTTTGATCCTTTCTTTGCTT	0.308													18	105	---	---	---	---	PASS
DRD2	1813	broad.mit.edu	37	11	113283559	113283559	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113283559C>T	uc001pnz.2	-	6	1178	c.857G>A	c.(856-858)AGC>AAC	p.S286N	DRD2_uc010rwv.1_Missense_Mutation_p.S285N|DRD2_uc001poa.3_Missense_Mutation_p.S286N|DRD2_uc001pob.3_Missense_Mutation_p.S257N	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	286	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	TGGGCTGGTGCTGGAGAGCAT	0.667													19	27	---	---	---	---	PASS
FAM55A	120400	broad.mit.edu	37	11	114401156	114401156	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:114401156G>T	uc001ppa.2	-	3	565	c.148C>A	c.(148-150)CTC>ATC	p.L50I	FAM55A_uc010rxd.1_5'UTR|FAM55A_uc001ppb.1_Missense_Mutation_p.L192I	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	192						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		GCCCTCCAGAGAGCCGACGCC	0.507													40	60	---	---	---	---	PASS
OR6M1	390261	broad.mit.edu	37	11	123676935	123676935	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123676935G>T	uc010rzz.1	-	1	123	c.123C>A	c.(121-123)ATC>ATA	p.I41I		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		AGATGATGGTGATGTTTCCTG	0.423													22	109	---	---	---	---	PASS
OR4D5	219875	broad.mit.edu	37	11	123810615	123810615	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123810615C>A	uc001pzk.1	+	1	292	c.292C>A	c.(292-294)CTG>ATG	p.L98M		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGGTGGATGCCTGACTCAACT	0.493													16	97	---	---	---	---	PASS
OR6T1	219874	broad.mit.edu	37	11	123813951	123813951	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123813951C>A	uc010sab.1	-	1	595	c.595G>T	c.(595-597)GCT>TCT	p.A199S		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AGCATGAAAGCCACCAGTTTC	0.547													32	61	---	---	---	---	PASS
OR6T1	219874	broad.mit.edu	37	11	123813952	123813952	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123813952C>A	uc010sab.1	-	1	594	c.594G>T	c.(592-594)GTG>GTT	p.V198V		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GCATGAAAGCCACCAGTTTCA	0.547													32	60	---	---	---	---	PASS
OR10G9	219870	broad.mit.edu	37	11	123894397	123894397	+	Silent	SNP	G	T	T	rs139365025	byFrequency	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123894397G>T	uc010sad.1	+	1	678	c.678G>T	c.(676-678)CGG>CGT	p.R226R		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCATCCTGCGGATCCACACCT	0.522													27	62	---	---	---	---	PASS
OR10G7	390265	broad.mit.edu	37	11	123909651	123909651	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123909651C>A	uc001pzq.1	-	1	58	c.58G>T	c.(58-60)GGG>TGG	p.G20W		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GCGTCCAGCCCTGGGGCATGG	0.557													14	60	---	---	---	---	PASS
OR8A1	390275	broad.mit.edu	37	11	124440904	124440904	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124440904A>G	uc010san.1	+	1	940	c.940A>G	c.(940-942)AAG>GAG	p.K314E		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	314	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		CAAGGAAGTAAAGGCTGCCGT	0.428													23	54	---	---	---	---	PASS
ROBO3	64221	broad.mit.edu	37	11	124748011	124748011	+	Nonsense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124748011G>A	uc001qbc.2	+	21	3357	c.3165G>A	c.(3163-3165)TGG>TGA	p.W1055*	ROBO3_uc010saq.1_3'UTR|ROBO3_uc001qbd.2_5'UTR|ROBO3_uc010sar.1_Nonsense_Mutation_p.W104*|ROBO3_uc001qbe.2_5'UTR|ROBO3_uc001qbf.1_5'UTR	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1055	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTCCAGAGTGGAGCCAGGGGG	0.617													6	15	---	---	---	---	PASS
CCDC15	80071	broad.mit.edu	37	11	124908348	124908348	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124908348A>T	uc001qbm.3	+	14	2692	c.2433A>T	c.(2431-2433)CAA>CAT	p.Q811H		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	811	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AGAGAGAGCAAGAATGTTATG	0.318													3	13	---	---	---	---	PASS
ACRV1	56	broad.mit.edu	37	11	125548074	125548074	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125548074C>G	uc001qcs.2	-	2	438	c.171G>C	c.(169-171)GAG>GAC	p.E57D	ACRV1_uc001qck.2_Intron|ACRV1_uc001qcl.2_Intron|ACRV1_uc001qcm.2_Intron|ACRV1_uc001qcn.2_Intron|ACRV1_uc001qco.2_Intron|ACRV1_uc001qcp.2_Intron|ACRV1_uc001qcq.2_Intron|ACRV1_uc001qcr.2_Missense_Mutation_p.E57D	NM_001612	NP_001603	P26436	ASPX_HUMAN	acrosomal vesicle protein 1 isoform a precursor	57					multicellular organismal development	acrosomal vesicle					0	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0179)|Lung NSC(97;0.0185)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0713)		CTGAAGAAGTCTCATATAAAG	0.458													29	43	---	---	---	---	PASS
PRDM10	56980	broad.mit.edu	37	11	129802064	129802064	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:129802064C>A	uc001qfm.2	-	10	1452	c.1220G>T	c.(1219-1221)CGT>CTT	p.R407L	PRDM10_uc001qfj.2_Missense_Mutation_p.R321L|PRDM10_uc001qfk.2_Missense_Mutation_p.R321L|PRDM10_uc001qfl.2_Missense_Mutation_p.R321L|PRDM10_uc010sbx.1_Missense_Mutation_p.R321L|PRDM10_uc001qfn.2_Missense_Mutation_p.R407L|PRDM10_uc009zct.1_Missense_Mutation_p.R439L	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	407					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TTTTGGAGGACGCCCCGGCCG	0.572													3	77	---	---	---	---	PASS
FBXL14	144699	broad.mit.edu	37	12	1702723	1702723	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1702723G>T	uc001qjh.2	-	1	609	c.510C>A	c.(508-510)CGC>CGA	p.R170R	WNT5B_uc009zdq.2_Intron|FBXL14_uc001qji.2_Silent_p.R82R	NM_152441	NP_689654	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	170	LRR 2.					cytoplasm				ovary(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)			GGCTCTTGAGGCGCTGCAGAC	0.667													10	24	---	---	---	---	PASS
CACNA2D4	93589	broad.mit.edu	37	12	1992086	1992086	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1992086C>G	uc001qjp.2	-	13	1663	c.1432G>C	c.(1432-1434)GTC>CTC	p.V478L	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.V366L	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	478	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TGGTTGATGACCATGGGGCGG	0.607													14	30	---	---	---	---	PASS
CACNA1C	775	broad.mit.edu	37	12	2788654	2788654	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2788654C>A	uc009zdu.1	+	44	5593	c.5280C>A	c.(5278-5280)AGC>AGA	p.S1760R	CACNA1C_uc009zdv.1_Missense_Mutation_p.S1709R|CACNA1C_uc001qkb.2_Missense_Mutation_p.S1712R|CACNA1C_uc001qkc.2_Missense_Mutation_p.S1731R|CACNA1C_uc001qke.2_Missense_Mutation_p.S1701R|CACNA1C_uc001qkf.2_Missense_Mutation_p.S1720R|CACNA1C_uc001qjz.2_Missense_Mutation_p.S1712R|CACNA1C_uc001qkd.2_Missense_Mutation_p.S1731R|CACNA1C_uc001qkg.2_Missense_Mutation_p.S1718R|CACNA1C_uc009zdw.1_Missense_Mutation_p.S1753R|CACNA1C_uc001qkh.2_Missense_Mutation_p.S1720R|CACNA1C_uc001qkl.2_Missense_Mutation_p.S1760R|CACNA1C_uc001qkn.2_Missense_Mutation_p.S1712R|CACNA1C_uc001qko.2_Missense_Mutation_p.S1732R|CACNA1C_uc001qkp.2_Missense_Mutation_p.S1712R|CACNA1C_uc001qkr.2_Missense_Mutation_p.S1729R|CACNA1C_uc001qku.2_Missense_Mutation_p.S1712R|CACNA1C_uc001qkq.2_Missense_Mutation_p.S1740R|CACNA1C_uc001qks.2_Missense_Mutation_p.S1712R|CACNA1C_uc001qkt.2_Missense_Mutation_p.S1731R|CACNA1C_uc001qki.1_Missense_Mutation_p.S1448R|CACNA1C_uc001qkj.1_Missense_Mutation_p.S1448R|CACNA1C_uc001qkk.1_Missense_Mutation_p.S1448R|CACNA1C_uc001qkm.1_Missense_Mutation_p.S1437R|CACNA1C_uc010sea.1_Missense_Mutation_p.S403R|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.S30R	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1760	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACTACCAAAGCGACGGCCGGA	0.657													7	10	---	---	---	---	PASS
FGF23	8074	broad.mit.edu	37	12	4479738	4479738	+	Missense_Mutation	SNP	C	T	T	rs104894347		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4479738C>T	uc001qmq.1	-	3	673	c.527G>A	c.(526-528)CGG>CAG	p.R176Q		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	176			R -> Q (in ADHR; partially resistant to cleavage by furin).		cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CCGGGTGTGCCGCCGTGGTAT	0.672													12	79	---	---	---	---	PASS
PEX5	5830	broad.mit.edu	37	12	7355220	7355220	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7355220G>A	uc009zfu.1	+	10	1346	c.766G>A	c.(766-768)GCC>ACC	p.A256T	PEX5_uc001qsw.2_Missense_Mutation_p.A256T|PEX5_uc010sgc.1_Missense_Mutation_p.A271T|PEX5_uc001qsu.2_Missense_Mutation_p.A219T|PEX5_uc010sgd.1_Missense_Mutation_p.A277T|PEX5_uc001qsv.2_Missense_Mutation_p.A256T	NM_001131026	NP_001124498	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5 isoform d	256					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			ovary(1)	1						TACATCAGATGCCTGGGTTGA	0.478													26	46	---	---	---	---	PASS
CD163L1	283316	broad.mit.edu	37	12	7548873	7548873	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7548873T>C	uc001qsy.2	-	8	1894	c.1868A>G	c.(1867-1869)CAG>CGG	p.Q623R	CD163L1_uc010sge.1_Missense_Mutation_p.Q633R	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	623	SRCR 6.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GCAGTCCAGCTGGCTACACAC	0.517													17	54	---	---	---	---	PASS
GDF3	9573	broad.mit.edu	37	12	7843099	7843099	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7843099C>A	uc001qte.2	-	2	506	c.470G>T	c.(469-471)GGC>GTC	p.G157V		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	157					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GGTGGTCTGGCCCCACACATG	0.552													34	84	---	---	---	---	PASS
GRIN2B	2904	broad.mit.edu	37	12	13716820	13716820	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:13716820C>A	uc001rbt.2	-	13	3531	c.3352G>T	c.(3352-3354)GAC>TAC	p.D1118Y		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1118	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGCTTGTGGTCAGGGGAGCGG	0.607													30	67	---	---	---	---	PASS
GRIN2B	2904	broad.mit.edu	37	12	13906657	13906657	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:13906657C>G	uc001rbt.2	-	3	783	c.604G>C	c.(604-606)GTC>CTC	p.V202L		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	202	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGTAGGAGGACCTCCTCTAGC	0.473													54	99	---	---	---	---	PASS
SLCO1B3	28234	broad.mit.edu	37	12	21229443	21229443	+	Nonsense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21229443G>A	uc010sil.1	+	15	2053	c.1988G>A	c.(1987-1989)TGG>TAG	p.W663*	LST-3TM12_uc010sim.1_Nonsense_Mutation_p.W602*|LST-3TM12_uc010sin.1_Nonsense_Mutation_p.W555*			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TGTATGAAGTGGTCCACCAAC	0.348													117	250	---	---	---	---	PASS
SLCO1A2	6579	broad.mit.edu	37	12	21450348	21450348	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21450348G>T	uc001rer.2	-	8	1316	c.1065C>A	c.(1063-1065)ATC>ATA	p.I355I	SLCO1A2_uc001res.2_Silent_p.I355I|SLCO1A2_uc010siq.1_Silent_p.I223I|SLCO1A2_uc010sio.1_Silent_p.I223I|SLCO1A2_uc010sip.1_Silent_p.I223I|SLCO1A2_uc001ret.2_Silent_p.I353I|SLCO1A2_uc001reu.2_Silent_p.I335I	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	355	Helical; Name=8; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CCATTAGAAAGATTGCATCTG	0.403													41	86	---	---	---	---	PASS
IAPP	3375	broad.mit.edu	37	12	21526284	21526284	+	5'UTR	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21526284C>A	uc001rev.2	+	2					SLCO1A2_uc001res.2_Intron|SLCO1A2_uc010siq.1_Intron	NM_000415	NP_000406	P10997	IAPP_HUMAN	islet amyloid polypeptide precursor						apoptosis|cell-cell signaling|endocrine pancreas development|signal transduction	extracellular region|soluble fraction	hormone activity				0					Perindopril(DB00790)	ATTTGAGAAGCAATGGGCATC	0.343													20	92	---	---	---	---	PASS
IAPP	3375	broad.mit.edu	37	12	21526285	21526285	+	5'UTR	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21526285A>C	uc001rev.2	+	2					SLCO1A2_uc001res.2_Intron|SLCO1A2_uc010siq.1_Intron	NM_000415	NP_000406	P10997	IAPP_HUMAN	islet amyloid polypeptide precursor						apoptosis|cell-cell signaling|endocrine pancreas development|signal transduction	extracellular region|soluble fraction	hormone activity				0					Perindopril(DB00790)	TTTGAGAAGCAATGGGCATCC	0.338													20	95	---	---	---	---	PASS
SYT10	341359	broad.mit.edu	37	12	33538175	33538175	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:33538175C>A	uc001rll.1	-	4	1426	c.1129G>T	c.(1129-1131)GCT>TCT	p.A377S	SYT10_uc009zju.1_Missense_Mutation_p.A187S	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	377	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					ATACGCCCAGCCGTCGGTAGG	0.448													22	72	---	---	---	---	PASS
PDZRN4	29951	broad.mit.edu	37	12	41831825	41831825	+	Intron	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:41831825G>A	uc010skn.1	+						PDZRN4_uc001rmq.3_Intron|PDZRN4_uc009zjz.2_Intron	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2								ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GGTGAGTGCAGGGTCTGATAC	0.413													53	123	---	---	---	---	PASS
PDZRN4	29951	broad.mit.edu	37	12	41966841	41966841	+	Missense_Mutation	SNP	C	G	G	rs139658899	byFrequency	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:41966841C>G	uc010skn.1	+	10	1731	c.1663C>G	c.(1663-1665)CGT>GGT	p.R555G	PDZRN4_uc001rmq.3_Missense_Mutation_p.R496G|PDZRN4_uc009zjz.2_Missense_Mutation_p.R494G|PDZRN4_uc001rmr.2_Missense_Mutation_p.R381G	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	754							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CACTGTAGACCGTTCCCCTGA	0.507													56	115	---	---	---	---	PASS
YAF2	10138	broad.mit.edu	37	12	42554479	42554479	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:42554479C>A	uc001rmv.2	-	4	523	c.455G>T	c.(454-456)GGC>GTC	p.G152V	YAF2_uc001rmw.2_Missense_Mutation_p.G176V|YAF2_uc010sko.1_Missense_Mutation_p.G143V|YAF2_uc010skp.1_Missense_Mutation_p.G110V	NM_005748	NP_005739	Q8IY57	YAF2_HUMAN	YY1 associated factor 2	152					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|zinc ion binding				0	all_cancers(12;0.000425)	Lung NSC(34;0.0402)|all_lung(34;0.057)		GBM - Glioblastoma multiforme(48;0.0514)		AGAGCTAGAGCCGCTTTGACT	0.428													19	55	---	---	---	---	PASS
PLEKHA9	51054	broad.mit.edu	37	12	45567135	45567135	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:45567135C>A	uc001rom.1	-	3	1551	c.1014G>T	c.(1012-1014)GCG>GCT	p.A338A	PLEKHA9_uc009zke.2_Silent_p.A338A	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		TTAAAGCTAACGCAAAAACCC	0.463													41	106	---	---	---	---	PASS
ANO6	196527	broad.mit.edu	37	12	45771835	45771835	+	Splice_Site	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:45771835G>C	uc001roo.2	+	10	1440	c.1105_splice	c.e10-1	p.K369_splice	ANO6_uc010sld.1_Splice_Site_p.K369_splice|ANO6_uc010sle.1_Splice_Site_p.K369_splice|ANO6_uc010slf.1_Splice_Site_p.K390_splice|ANO6_uc010slg.1_Splice_Site_p.K351_splice	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a						activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						ATATTTTCCAGAAATTGTGCA	0.313													59	141	---	---	---	---	PASS
KCNH3	23416	broad.mit.edu	37	12	49937247	49937247	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49937247G>T	uc001ruh.1	+	5	1029	c.769G>T	c.(769-771)GCC>TCC	p.A257S	KCNH3_uc010smj.1_Missense_Mutation_p.A197S	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	257	Extracellular (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						GCCCAGTGCCGCCCGCGGCCC	0.667													22	39	---	---	---	---	PASS
GALNT6	11226	broad.mit.edu	37	12	51748185	51748185	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51748185T>G	uc001ryk.2	-	11	2072	c.1847A>C	c.(1846-1848)CAT>CCT	p.H616P	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.H616P|GALNT6_uc001ryj.1_Missense_Mutation_p.H181P	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	616	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						CCACAACTGATGGGGGTCACT	0.542													16	43	---	---	---	---	PASS
KRT85	3891	broad.mit.edu	37	12	52761150	52761150	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52761150C>T	uc001sag.2	-	1	160	c.40G>A	c.(40-42)GTC>ATC	p.V14I		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	14	Head.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TTCCTGGTGACCCCGCATCCT	0.652													11	24	---	---	---	---	PASS
KRT72	140807	broad.mit.edu	37	12	52981525	52981525	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52981525C>A	uc001sar.2	-	7	1286	c.1200G>T	c.(1198-1200)AAG>AAT	p.K400N	KRT72_uc001saq.2_Missense_Mutation_p.K400N|KRT72_uc010sns.1_Missense_Mutation_p.K358N|KRT72_uc010snt.1_Missense_Mutation_p.K212N	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	400	Coil 2.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		CCAGCTCCTCCTTGGCCTGGT	0.662													4	102	---	---	---	---	PASS
NEUROD4	58158	broad.mit.edu	37	12	55420434	55420434	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55420434G>T	uc001sgp.3	+	2	589	c.211G>T	c.(211-213)GGT>TGT	p.G71C		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	71					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						TAAGAGAAGGGGTCCCAAGAA	0.433													28	47	---	---	---	---	PASS
PAN2	9924	broad.mit.edu	37	12	56716415	56716415	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56716415T>A	uc001skx.2	-	18	3006	c.2633A>T	c.(2632-2634)TAC>TTC	p.Y878F	PAN2_uc001skw.2_Missense_Mutation_p.Y26F|PAN2_uc001skz.2_Missense_Mutation_p.Y877F|PAN2_uc001sky.2_Missense_Mutation_p.Y874F	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	878					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						GCGCTGGTGGTAGGTCTCTCC	0.557													28	72	---	---	---	---	PASS
SRGAP1	57522	broad.mit.edu	37	12	64491063	64491063	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64491063A>G	uc010ssp.1	+	15	1777	c.1721A>G	c.(1720-1722)AAC>AGC	p.N574S	SRGAP1_uc001srv.2_Missense_Mutation_p.N511S	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	574	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CATGATATTAACTCAGTTGCT	0.368													62	88	---	---	---	---	PASS
PTPRB	5787	broad.mit.edu	37	12	70925933	70925933	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:70925933G>T	uc001swb.3	-	30	5762	c.5732C>A	c.(5731-5733)ACT>AAT	p.T1911N	uc001svz.2_Intron|PTPRB_uc010sto.1_Missense_Mutation_p.T1821N|PTPRB_uc010stp.1_Missense_Mutation_p.T1821N|PTPRB_uc001swc.3_Missense_Mutation_p.T2129N|PTPRB_uc001swa.3_Missense_Mutation_p.T2041N	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1911	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AAAGGTTCCAGTCCTACCCAC	0.443													32	57	---	---	---	---	PASS
NAV3	89795	broad.mit.edu	37	12	78569142	78569142	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78569142A>T	uc001syp.2	+	25	5211	c.5038A>T	c.(5038-5040)ACA>TCA	p.T1680S	NAV3_uc001syo.2_Missense_Mutation_p.T1680S|NAV3_uc010sub.1_Missense_Mutation_p.T1166S|NAV3_uc009zsf.2_Missense_Mutation_p.T511S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1680						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAACAGTGCCACAAGCCATTC	0.423										HNSCC(70;0.22)			29	72	---	---	---	---	PASS
LRRIQ1	84125	broad.mit.edu	37	12	85459184	85459184	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85459184G>A	uc001tac.2	+	9	2647	c.2536G>A	c.(2536-2538)GAT>AAT	p.D846N	LRRIQ1_uc001tab.1_Missense_Mutation_p.D846N	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	846	LRR 2.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TAAGTACATTGATGCACAGGT	0.338													48	113	---	---	---	---	PASS
LRRIQ1	84125	broad.mit.edu	37	12	85515541	85515541	+	Silent	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85515541A>T	uc001tac.2	+	16	3555	c.3444A>T	c.(3442-3444)TCA>TCT	p.S1148S	LRRIQ1_uc001tab.1_Silent_p.S1148S	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1148	LRRCT.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ACTCTAATTCAGAAAGCCGCA	0.368													35	89	---	---	---	---	PASS
ALX1	8092	broad.mit.edu	37	12	85674243	85674243	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85674243C>A	uc001tae.3	+	1	208	c.204C>A	c.(202-204)ACC>ACA	p.T68T		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	68					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		TGGAGAGGACCTCGCCCTGTC	0.637													24	32	---	---	---	---	PASS
DUSP6	1848	broad.mit.edu	37	12	89744393	89744393	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:89744393C>G	uc001tay.2	-	2	1290	c.810G>C	c.(808-810)CAG>CAC	p.Q270H	DUSP6_uc001taz.2_Intron	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	270	Tyrosine-protein phosphatase.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						CAGGGAAAAACTGGGACAGGT	0.428													3	141	---	---	---	---	PASS
AMDHD1	144193	broad.mit.edu	37	12	96350744	96350744	+	Intron	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96350744A>T	uc001tel.1	+						AMDHD1_uc009zth.1_Intron	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1						histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						TGCCTAAGTAATCTCAGCCAG	0.587													7	209	---	---	---	---	PASS
APAF1	317	broad.mit.edu	37	12	99042501	99042501	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:99042501G>T	uc001tfz.2	+	3	813	c.236G>T	c.(235-237)GGA>GTA	p.G79V	APAF1_uc001tfy.2_Missense_Mutation_p.G79V|APAF1_uc001tga.2_Missense_Mutation_p.G79V|APAF1_uc001tgb.2_Missense_Mutation_p.G79V|APAF1_uc001tgc.2_Missense_Mutation_p.G79V	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	79	CARD.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	CTACATGAAGGATATAAAGAT	0.373													52	166	---	---	---	---	PASS
ANKS1B	56899	broad.mit.edu	37	12	100377981	100377981	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100377981C>A	uc001tge.1	-	1	452	c.35G>T	c.(34-36)CGC>CTC	p.R12L	ANKS1B_uc001tgf.1_5'UTR|ANKS1B_uc009ztt.1_Missense_Mutation_p.R12L	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	12	ANK 1.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ATTTCCAGTGCGAGCAGCTTC	0.632													18	40	---	---	---	---	PASS
SLC17A8	246213	broad.mit.edu	37	12	100774486	100774486	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100774486G>T	uc010svi.1	+	2	422	c.109G>T	c.(109-111)GAT>TAT	p.D37Y	SLC17A8_uc009ztx.2_Missense_Mutation_p.D37Y	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	37	Cytoplasmic (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TAGAAAAATCGATGGGACAAC	0.448													56	168	---	---	---	---	PASS
SLC17A8	246213	broad.mit.edu	37	12	100797919	100797919	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100797919C>T	uc010svi.1	+	9	1470	c.1157C>T	c.(1156-1158)ACT>ATT	p.T386I	SLC17A8_uc009ztx.2_Missense_Mutation_p.T336I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	386	Cytoplasmic (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TTAACCACAACTGCTGTCAGA	0.403													20	66	---	---	---	---	PASS
HCFC2	29915	broad.mit.edu	37	12	104476606	104476606	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104476606G>T	uc001tkj.3	+	7	1093	c.990G>T	c.(988-990)TGG>TGT	p.W330C	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	330					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						TGTATTTTTGGAGTGGAAGAG	0.393													51	107	---	---	---	---	PASS
ASCL4	121549	broad.mit.edu	37	12	108169133	108169133	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108169133C>A	uc001tmr.2	+	1	972	c.141C>A	c.(139-141)TGC>TGA	p.C47*		NM_203436	NP_982260	Q6XD76	ASCL4_HUMAN	achaete-scute complex-like 4	46					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1						ACGCCGCGTGCTGGGAGTGGG	0.746													10	19	---	---	---	---	PASS
RASAL1	8437	broad.mit.edu	37	12	113546027	113546027	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113546027C>G	uc001tum.1	-	15	1668	c.1375G>C	c.(1375-1377)GAT>CAT	p.D459H	RASAL1_uc010syp.1_Missense_Mutation_p.D459H|RASAL1_uc001tul.2_Missense_Mutation_p.D459H|RASAL1_uc001tun.1_Missense_Mutation_p.D460H|RASAL1_uc010syq.1_Missense_Mutation_p.D459H|RASAL1_uc001tuo.3_Missense_Mutation_p.D459H|RASAL1_uc010syr.1_Missense_Mutation_p.D459H	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	459	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						TACTTCACATCCTGCTGGGAG	0.532													3	20	---	---	---	---	PASS
RASAL1	8437	broad.mit.edu	37	12	113557020	113557020	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113557020C>A	uc001tum.1	-	8	848	c.555G>T	c.(553-555)GAG>GAT	p.E185D	RASAL1_uc010syp.1_Missense_Mutation_p.E185D|RASAL1_uc001tul.2_Missense_Mutation_p.E185D|RASAL1_uc001tun.1_Missense_Mutation_p.E185D|RASAL1_uc010syq.1_Missense_Mutation_p.E185D|RASAL1_uc001tuo.3_Missense_Mutation_p.E185D|RASAL1_uc010syr.1_Missense_Mutation_p.E185D	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	185	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						TCTCCCGCAGCTCCAGCACTT	0.612													24	65	---	---	---	---	PASS
TMEM132D	121256	broad.mit.edu	37	12	129563197	129563197	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:129563197G>A	uc009zyl.1	-	8	2325	c.1997C>T	c.(1996-1998)ACA>ATA	p.T666I	TMEM132D_uc001uia.2_Missense_Mutation_p.T204I	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	666	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CCCGAGGTCTGTGATGGTCAC	0.572													33	90	---	---	---	---	PASS
RIMBP2	23504	broad.mit.edu	37	12	130927212	130927212	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130927212G>T	uc001uil.2	-						RIMBP2_uc001uim.2_Intron|RIMBP2_uc001uin.1_5'Flank	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2							cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCTCCTGTTGGGTACAAGGAC	0.612													16	34	---	---	---	---	PASS
MMP17	4326	broad.mit.edu	37	12	132335568	132335568	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132335568C>A	uc001ujc.1	+	10	1660	c.1561C>A	c.(1561-1563)CTG>ATG	p.L521M	MMP17_uc001ujd.1_Missense_Mutation_p.L437M	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	521	Hemopexin-like 4.				proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CCGGGACTGGCTGGTGTGTGG	0.672													3	15	---	---	---	---	PASS
SACS	26278	broad.mit.edu	37	13	23929996	23929996	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23929996C>A	uc001uon.2	-	8	1344	c.755G>T	c.(754-756)GGC>GTC	p.G252V	SACS_uc001uoo.2_Missense_Mutation_p.G105V|SACS_uc001uop.1_Missense_Mutation_p.G39V|SACS_uc001uoq.1_Missense_Mutation_p.G105V	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	252					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCCAAAAATGCCAACAAATGG	0.398													47	97	---	---	---	---	PASS
MIPEP	4285	broad.mit.edu	37	13	24304513	24304513	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:24304513C>T	uc001uox.3	-	19	2216	c.2116G>A	c.(2116-2118)GAA>AAA	p.E706K		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	706					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		AGGAAAGTTTCGAAGTCCAGA	0.413													18	37	---	---	---	---	PASS
ATP12A	479	broad.mit.edu	37	13	25264605	25264605	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25264605T>G	uc001upp.2	+	6	863	c.676T>G	c.(676-678)TGT>GGT	p.C226G	ATP12A_uc010aaa.2_Missense_Mutation_p.C226G	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	226	Cytoplasmic (Potential).			Missing (in Ref. 7; CAA49477).	ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TTCTCAGGGGTGTCGGGTAAG	0.572													70	85	---	---	---	---	PASS
ATP12A	479	broad.mit.edu	37	13	25284659	25284659	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25284659T>C	uc001upp.2	+	20	3012	c.2825T>C	c.(2824-2826)CTA>CCA	p.L942P	ATP12A_uc010aaa.2_Missense_Mutation_p.L948P	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	942	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	gttggcatcctagtccagcaa	0.423													80	121	---	---	---	---	PASS
FLT1	2321	broad.mit.edu	37	13	28880918	28880918	+	Intron	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28880918A>T	uc001usb.3	-						FLT1_uc010aap.2_Intron|FLT1_uc010aaq.2_Intron|FLT1_uc001usa.3_Intron	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1						cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TCCTAGGGGGAGAAGGAGAAA	0.582													23	44	---	---	---	---	PASS
FRY	10129	broad.mit.edu	37	13	32752551	32752551	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32752551G>T	uc001utx.2	+	21	3155	c.2659G>T	c.(2659-2661)GTG>TTG	p.V887L	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	887					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GCTCCAGTCGGTGATGCCTCT	0.507													69	215	---	---	---	---	PASS
FRY	10129	broad.mit.edu	37	13	32798403	32798403	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32798403G>C	uc001utx.2	+	37	5293	c.4797G>C	c.(4795-4797)TTG>TTC	p.L1599F	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CGGGCTGGTTGCTGACTATTA	0.512													66	80	---	---	---	---	PASS
FRY	10129	broad.mit.edu	37	13	32813445	32813445	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32813445C>A	uc001utx.2	+	45	6971	c.6475C>A	c.(6475-6477)CCC>ACC	p.P2159T	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TTTTGAAAATCCCAATCAGTT	0.443													45	165	---	---	---	---	PASS
BRCA2	675	broad.mit.edu	37	13	32912926	32912926	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32912926A>G	uc001uub.1	+	11	4661	c.4434A>G	c.(4432-4434)CTA>CTG	p.L1478L		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1478					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TGGACATTCTAAGTTATGAGG	0.338			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			95	106	---	---	---	---	PASS
NBEA	26960	broad.mit.edu	37	13	35770090	35770090	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:35770090A>G	uc001uvb.2	+	31	5223	c.5017A>G	c.(5017-5019)ACA>GCA	p.T1673A	NBEA_uc010abi.2_Missense_Mutation_p.T329A	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1673						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AATTCCCCATACAGATTCAGG	0.428													35	68	---	---	---	---	PASS
C13orf23	80209	broad.mit.edu	37	13	39603500	39603500	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:39603500C>G	uc001uwy.2	-	4	1066	c.193G>C	c.(193-195)GTC>CTC	p.V65L	C13orf23_uc001uwz.2_Missense_Mutation_p.V43L	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	65										ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GTTGGCTGGACAGCCACCATT	0.313													14	106	---	---	---	---	PASS
NEK5	341676	broad.mit.edu	37	13	52657401	52657401	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52657401C>A	uc001vge.2	-	17	1707	c.1567G>T	c.(1567-1569)GTG>TTG	p.V523L		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	523							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		ATTACCTGCACAGGTGCTTCT	0.343													11	78	---	---	---	---	PASS
OLFM4	10562	broad.mit.edu	37	13	53603017	53603017	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53603017G>T	uc001vhl.2	+	1	46	c.46G>T	c.(46-48)GGC>TGC	p.G16C	OLFM4_uc001vhk.1_Missense_Mutation_p.G16C	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	16					cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GTTCTTCCTTGGCCAAGCTGC	0.512													83	159	---	---	---	---	PASS
PCDH9	5101	broad.mit.edu	37	13	67477735	67477735	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:67477735A>G	uc001vik.2	-	3	3731	c.3039T>C	c.(3037-3039)TGT>TGC	p.C1013C	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Intron|PCDH9_uc010thl.1_Silent_p.C1013C	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1013	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TGTGTGAGTTACACTGAAAGA	0.418													32	29	---	---	---	---	PASS
ZIC2	7546	broad.mit.edu	37	13	100637597	100637597	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:100637597G>A	uc001von.2	+	3	1260	c.1260G>A	c.(1258-1260)CAG>CAA	p.Q420Q		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	420					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCTCCCCGCAGGGCTCTGAAT	0.706													9	25	---	---	---	---	PASS
NALCN	259232	broad.mit.edu	37	13	101760037	101760037	+	Intron	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101760037A>G	uc001vox.1	-							NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1							integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGGACACTGCAGCAACCTGTA	0.418													14	69	---	---	---	---	PASS
NALCN	259232	broad.mit.edu	37	13	101833559	101833559	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101833559G>T	uc001vox.1	-						NALCN_uc001voy.2_Intron|NALCN_uc001voz.2_Missense_Mutation_p.P632T|NALCN_uc001vpa.2_Missense_Mutation_p.P632T	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1							integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATTCCAGGTGGTGTGGTGAGG	0.557													21	117	---	---	---	---	PASS
COL4A2	1284	broad.mit.edu	37	13	111117775	111117775	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111117775A>G	uc001vqx.2	+	25	2089	c.1800A>G	c.(1798-1800)CCA>CCG	p.P600P		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	600	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGGGCCCTCCAGGGGACCCAG	0.512													52	80	---	---	---	---	PASS
TFDP1	7027	broad.mit.edu	37	13	114287509	114287509	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114287509A>C	uc001vtw.2	+	6	595	c.383A>C	c.(382-384)CAG>CCG	p.Q128P	TFDP1_uc010tkd.1_Missense_Mutation_p.Q33P|TFDP1_uc010tke.1_Missense_Mutation_p.Q33P|TFDP1_uc001vty.3_Missense_Mutation_p.Q128P|TFDP1_uc001vtx.2_Missense_Mutation_p.Q8P|TFDP1_uc010agx.2_Missense_Mutation_p.Q128P	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	128	Potential.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			GAGAAGGTGCAGAGGAAAGGG	0.502										TSP Lung(29;0.18)			11	57	---	---	---	---	PASS
OR4K15	81127	broad.mit.edu	37	14	20444091	20444091	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20444091C>T	uc010tkx.1	+	1	414	c.414C>T	c.(412-414)CTC>CTT	p.L138L		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	138	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAATGGTGCTCCTAGTTTCCA	0.458													56	167	---	---	---	---	PASS
TTC5	91875	broad.mit.edu	37	14	20770004	20770004	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20770004C>G	uc001vwt.2	-	2	229	c.172G>C	c.(172-174)GAA>CAA	p.E58Q	TTC5_uc001vwu.2_5'UTR	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	58					DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		ACTACTTCTTCCATCTGCTGT	0.468													22	88	---	---	---	---	PASS
OR10G3	26533	broad.mit.edu	37	14	22038500	22038500	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22038500C>T	uc010tmb.1	-	1	376	c.376G>A	c.(376-378)GCA>ACA	p.A126T		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		TGACATATTGCCAGGTACCTG	0.552													10	45	---	---	---	---	PASS
DHRS2	10202	broad.mit.edu	37	14	24108548	24108548	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24108548G>A	uc001wkt.3	+	3	748	c.301G>A	c.(301-303)GAG>AAG	p.E101K	DHRS2_uc010aku.1_Missense_Mutation_p.E101K|DHRS2_uc001wku.3_Missense_Mutation_p.E101K|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Missense_Mutation_p.E101K	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	79					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		TGAGGACCGGGAGCAGCTGGT	0.657													19	26	---	---	---	---	PASS
DHRS2	10202	broad.mit.edu	37	14	24113371	24113371	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24113371G>T	uc001wkt.3	+	6	987	c.540G>T	c.(538-540)GTG>GTT	p.V180V	DHRS2_uc001wku.3_Silent_p.V180V|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Silent_p.V180V	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	158					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		ATCCAGTAGTGGTAAGTGCTT	0.498													45	105	---	---	---	---	PASS
NOVA1	4857	broad.mit.edu	37	14	26917820	26917820	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:26917820C>A	uc001wpy.2	-	5	1187	c.869G>T	c.(868-870)GGA>GTA	p.G290V	NOVA1_uc001wpz.2_Missense_Mutation_p.G266V|NOVA1_uc001wqa.2_Missense_Mutation_p.G168V	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	293	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		GTTAGCATGTCCTAATAGCCC	0.498													14	71	---	---	---	---	PASS
PRKD1	5587	broad.mit.edu	37	14	30194873	30194873	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:30194873T>G	uc001wqh.2	-	2	453	c.272A>C	c.(271-273)GAA>GCA	p.E91A		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	91					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GAAACCACATTCAGGGAACTG	0.383													3	86	---	---	---	---	PASS
CLEC14A	161198	broad.mit.edu	37	14	38724223	38724223	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:38724223T>G	uc001wum.1	-	1	1352	c.1005A>C	c.(1003-1005)GAA>GAC	p.E335D		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	335	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		AATTGTCTTGTTCAGGGACAA	0.562													20	92	---	---	---	---	PASS
KTN1	3895	broad.mit.edu	37	14	56146364	56146364	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:56146364C>A	uc001xcb.2	+	44	4332	c.4030C>A	c.(4030-4032)CAA>AAA	p.Q1344K	KTN1_uc001xce.2_Missense_Mutation_p.Q1287K|KTN1_uc001xcc.2_Missense_Mutation_p.Q1344K|KTN1_uc001xcd.2_Missense_Mutation_p.Q1293K|KTN1_uc010trb.1_Missense_Mutation_p.Q1316K|KTN1_uc001xcf.1_Missense_Mutation_p.Q1293K|KTN1_uc010aoq.2_Missense_Mutation_p.Q582K|KTN1_uc010trc.1_Missense_Mutation_p.Q321K|KTN1_uc001xcg.2_Missense_Mutation_p.Q277K	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	1344	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						GGCGGTAAACCAACAGCTCAC	0.408			T	RET	papillary thryoid								42	82	---	---	---	---	PASS
ACTR10	55860	broad.mit.edu	37	14	58701178	58701178	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58701178G>A	uc001xdf.2	+	13	1266	c.1163G>A	c.(1162-1164)TGT>TAT	p.C388Y	C14orf37_uc010tro.1_Intron|ACTR10_uc001xdg.2_Missense_Mutation_p.C190Y|ACTR10_uc001xdh.2_Missense_Mutation_p.C190Y|ACTR10_uc010trp.1_RNA|ACTR10_uc010apc.2_Missense_Mutation_p.C178Y	NM_018477	NP_060947	Q9NZ32	ARP10_HUMAN	uncharacterized hypothalamus protein HARP11	388						cytoplasm				central_nervous_system(1)	1						CCTGATTGGTGTTCTCTCAAT	0.408													32	133	---	---	---	---	PASS
SIX1	6495	broad.mit.edu	37	14	61113136	61113136	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61113136G>A	uc001xfb.3	-	2	968	c.720C>T	c.(718-720)CAC>CAT	p.H240H		NM_005982	NP_005973	Q15475	SIX1_HUMAN	SIX homeobox 1	240					branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		AGCTCCTGGCGTGGCCCATAT	0.597													38	81	---	---	---	---	PASS
GPHB5	122876	broad.mit.edu	37	14	63779814	63779814	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:63779814G>C	uc010apu.2	-	3	220	c.220C>G	c.(220-222)CCC>GCC	p.P74A	GPHB5_uc001xgc.2_Missense_Mutation_p.P64A	NM_145171	NP_660154	Q86YW7	GPHB5_HUMAN	glycoprotein beta 5	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						extracellular region	hormone activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00372)|all cancers(60;0.0226)|BRCA - Breast invasive adenocarcinoma(234;0.0978)		AATATAGGGGGGTTCCAGAAT	0.388													5	7	---	---	---	---	PASS
HSPA2	3306	broad.mit.edu	37	14	65008114	65008114	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65008114G>T	uc001xhj.2	+	2	623	c.547G>T	c.(547-549)GCC>TCC	p.A183S	HSPA2_uc001xhk.3_Missense_Mutation_p.A183S	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	183					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GGCGGCCATCGCCTACGGCCT	0.632													27	52	---	---	---	---	PASS
SPTB	6710	broad.mit.edu	37	14	65246617	65246617	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65246617C>T	uc001xht.2	-	20	4353	c.4299G>A	c.(4297-4299)GAG>GAA	p.E1433E	SPTB_uc001xhr.2_Silent_p.E1433E|SPTB_uc001xhs.2_Silent_p.E1433E|SPTB_uc001xhu.2_Silent_p.E1433E|SPTB_uc010aqi.2_Silent_p.E94E	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1433	Spectrin 11.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCCCCAGCTCCTCTTTTCGCA	0.507													44	148	---	---	---	---	PASS
SPTB	6710	broad.mit.edu	37	14	65253222	65253222	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65253222C>T	uc001xht.2	-	15	3515	c.3461G>A	c.(3460-3462)GGC>GAC	p.G1154D	SPTB_uc001xhr.2_Missense_Mutation_p.G1154D|SPTB_uc001xhs.2_Missense_Mutation_p.G1154D|SPTB_uc001xhu.2_Missense_Mutation_p.G1154D	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1154	Spectrin 9.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCACATCCTGCCCAGGGCATT	0.607													6	25	---	---	---	---	PASS
RDH12	145226	broad.mit.edu	37	14	68191292	68191292	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68191292A>C	uc001xjz.3	+	4	495	c.171A>C	c.(169-171)AGA>AGC	p.R57S		NM_152443	NP_689656	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12	57					photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	AGACGGCCAGAGAGCTCGCTA	0.547													12	50	---	---	---	---	PASS
ZFYVE26	23503	broad.mit.edu	37	14	68241800	68241800	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68241800G>C	uc001xka.2	-	27	5392	c.5253C>G	c.(5251-5253)CAC>CAG	p.H1751Q	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.H1751Q	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1751					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTGCAGCCTGGTGGACAATTT	0.458													4	20	---	---	---	---	PASS
SLC8A3	6547	broad.mit.edu	37	14	70522529	70522529	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:70522529C>A	uc001xly.2	-	4	2644	c.1890G>T	c.(1888-1890)GCG>GCT	p.A630A	SLC8A3_uc001xlu.2_Intron|SLC8A3_uc001xlv.2_Intron|SLC8A3_uc001xlw.2_Silent_p.A630A|SLC8A3_uc001xlx.2_Silent_p.A631A|SLC8A3_uc001xlz.2_Intron|SLC8A3_uc010ara.2_Intron|SLC8A3_uc001xma.2_Intron	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	630	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding	p.A630E(1)		skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ATAACAGGAGCGCTGTTTGCA	0.418													8	22	---	---	---	---	PASS
PCNX	22990	broad.mit.edu	37	14	71493521	71493521	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:71493521A>T	uc001xmo.2	+	15	3834	c.3388A>T	c.(3388-3390)ATT>TTT	p.I1130F	PCNX_uc010are.1_Missense_Mutation_p.I1019F|PCNX_uc010arf.1_5'UTR	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1130	Helical; (Potential).					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AGTGTTTTTCATTGGTCTCCT	0.308													37	110	---	---	---	---	PASS
ZFYVE1	53349	broad.mit.edu	37	14	73491086	73491086	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73491086C>A	uc001xnm.2	-	2	771	c.131G>T	c.(130-132)CGC>CTC	p.R44L	ZFYVE1_uc010arj.2_Missense_Mutation_p.R44L	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	44						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		CTCCTCGCAGCGGAGACACTG	0.567													36	83	---	---	---	---	PASS
UBR7	55148	broad.mit.edu	37	14	93684957	93684957	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93684957G>T	uc001ybm.3	+	7	922	c.686G>T	c.(685-687)GGA>GTA	p.G229V	UBR7_uc001ybn.3_Missense_Mutation_p.G153V|UBR7_uc010auq.2_Missense_Mutation_p.G78V	NM_175748	NP_786924	Q8N806	UBR7_HUMAN	ubiquitin protein ligase E3 component n-recognin	229							ubiquitin-protein ligase activity|zinc ion binding				0						CCTGAAAATGGAGAGCATCAA	0.443													29	58	---	---	---	---	PASS
SERPINA4	5267	broad.mit.edu	37	14	95030431	95030431	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95030431C>T	uc001ydk.2	+	2	678	c.612C>T	c.(610-612)GAC>GAT	p.D204D	SERPINA4_uc010avd.2_Silent_p.D241D|SERPINA4_uc001ydl.2_Silent_p.D204D	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	204					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		TCAAGAAGGACGTCTTGATGG	0.453													59	150	---	---	---	---	PASS
DICER1	23405	broad.mit.edu	37	14	95571462	95571462	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95571462G>T	uc001ydw.2	-	21	3397	c.3215C>A	c.(3214-3216)GCC>GAC	p.A1072D	DICER1_uc010avh.1_5'UTR|DICER1_uc001ydv.2_Missense_Mutation_p.A1062D|DICER1_uc001ydx.2_Missense_Mutation_p.A1072D|DICER1_uc001ydy.1_5'Flank	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1072					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GGCAGTCTGGGCTCTTAGCTC	0.502			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				6	189	---	---	---	---	PASS
BCL11B	64919	broad.mit.edu	37	14	99642498	99642498	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:99642498T>C	uc001yga.2	-	4	942	c.675A>G	c.(673-675)ACA>ACG	p.T225T	BCL11B_uc001ygb.2_Silent_p.T154T	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	225	C2H2-type 1.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GCTGCTTGCATGTTGTGCAAA	0.637			T	TLX3	T-ALL								12	28	---	---	---	---	PASS
WARS	7453	broad.mit.edu	37	14	100828124	100828124	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100828124T>C	uc001yhf.1	-	2	318	c.234A>G	c.(232-234)ACA>ACG	p.T78T	WARS_uc001yhg.1_Silent_p.T78T|WARS_uc001yhh.1_Silent_p.T78T|WARS_uc001yhi.1_Silent_p.T37T|WARS_uc001yhj.1_Silent_p.T37T|WARS_uc001yhk.1_Silent_p.T37T|WARS_uc001yhl.1_Silent_p.T78T|WARS_uc010twz.1_Silent_p.T78T	NM_173701	NP_776049	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase isoform a	78					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(1)	1		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	CTTCAGCTTCTGTGGCATCTG	0.502													60	187	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	14	101521021	101521021	+	5'Flank	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101521021G>A	uc010txo.1	+						MIR134_hsa-mir-134|MI0000474_5'Flank|MIR668_hsa-mir-668|MI0003761_5'Flank|MIR485_hsa-mir-485|MI0002469_5'Flank|hsa-mir-323b|MI0014206_5'Flank					DM004407																		TGTCAGCACCGTCCAGGGTGT	0.582													17	27	---	---	---	---	PASS
WDR20	91833	broad.mit.edu	37	14	102606455	102606455	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102606455C>A	uc001ykz.2	+	1	244	c.195C>A	c.(193-195)CTC>CTA	p.L65L	WDR20_uc001yky.1_Translation_Start_Site|WDR20_uc001yla.2_Translation_Start_Site|WDR20_uc001ylb.2_Silent_p.L65L|WDR20_uc010txu.1_Silent_p.L65L|WDR20_uc001ylc.2_Silent_p.L65L|WDR20_uc001yld.2_Silent_p.L65L|WDR20_uc001yle.2_Silent_p.L65L|WDR20_uc001ylf.2_Silent_p.L65L|HSP90AA1_uc001ykv.3_5'Flank	NM_144574	NP_653175	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20 isoform 2	65											0						GCGACCGCCTCTGCTTCAATG	0.637													13	26	---	---	---	---	PASS
ADSSL1	122622	broad.mit.edu	37	14	105201411	105201411	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105201411C>T	uc001ypd.2	+	2	321	c.247C>T	c.(247-249)CAC>TAC	p.H83Y	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.H126Y|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	83					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	GTACGACTTCCACCTGCTGCC	0.612													10	18	---	---	---	---	PASS
ADAM6	8755	broad.mit.edu	37	14	106610580	106610580	+	RNA	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106610580C>A	uc010tyt.1	-	1167		c.26251G>T								Parts of antibodies, mostly variable regions.												0						CAGGCTTTACCAAGCCTCCCC	0.567													39	81	---	---	---	---	PASS
OR4N4	283694	broad.mit.edu	37	15	22383085	22383085	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22383085C>A	uc001yuc.1	+	7	1594	c.613C>A	c.(613-615)CTG>ATG	p.L205M	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.L205M	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CAACAGTGGCCTGATGACACT	0.517													12	199	---	---	---	---	PASS
C15orf2	23742	broad.mit.edu	37	15	24921812	24921812	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:24921812C>T	uc001ywo.2	+	1	1272	c.798C>T	c.(796-798)GCC>GCT	p.A266A		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	266					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTGAGCCAGCCGTTGGCTGCT	0.637													17	45	---	---	---	---	PASS
SNORD116-4	100033416	broad.mit.edu	37	15	25322271	25322271	+	Intron	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25322271C>A	uc001yxh.1	+						SNORD116-4_uc001yxm.1_Intron|IPW_uc001yxn.3_Intron|SNORD116-12_uc001yxv.1_RNA|SNORD116-13_uc001yxw.2_5'Flank					Homo sapiens clone kid4 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0						ATACCATCATCCTCATTGAAC	0.428													27	69	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	15	25486950	25486950	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25486950G>T	uc001zae.2	+						SNORD115-39_uc001zah.1_RNA|SNORD115-40_uc001zai.1_5'Flank					Homo sapiens clone Rt-16 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.																		TAAAAATCATGCTCAATAGGA	0.473													101	230	---	---	---	---	PASS
GABRB3	2562	broad.mit.edu	37	15	26825456	26825456	+	Intron	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:26825456C>T	uc001zaz.2	-						GABRB3_uc010uae.1_Intron|GABRB3_uc001zba.2_Intron|GABRB3_uc001zbb.2_Intron	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta						synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TAAGTGGATGCAGGACTCACC	0.552													26	84	---	---	---	---	PASS
FMN1	342184	broad.mit.edu	37	15	33180426	33180426	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33180426A>C	uc001zhf.3	-	12	3113	c.3113T>G	c.(3112-3114)GTC>GGC	p.V1038G		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	1261	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TTCAAACTTGACTTGGGAGGC	0.373													26	40	---	---	---	---	PASS
RYR3	6263	broad.mit.edu	37	15	34047380	34047380	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34047380A>T	uc001zhi.2	+	58	8584	c.8514A>T	c.(8512-8514)TTA>TTT	p.L2838F	RYR3_uc010bar.2_Missense_Mutation_p.L2838F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2838	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGCCCATTTAGGTAAGTATC	0.348													17	22	---	---	---	---	PASS
TMCO5A	145942	broad.mit.edu	37	15	38235579	38235579	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:38235579C>G	uc001zjw.2	+	9	710	c.607C>G	c.(607-609)CAT>GAT	p.H203D	TMCO5A_uc001zjv.1_Missense_Mutation_p.H203D	NM_152453	NP_689666	Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	203						integral to membrane				central_nervous_system(1)	1						GGAAAAAGAGCATACCAGCCA	0.408													23	57	---	---	---	---	PASS
RPAP1	26015	broad.mit.edu	37	15	41821753	41821753	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41821753C>A	uc001zod.2	-	9	1197	c.1073G>T	c.(1072-1074)CGA>CTA	p.R358L		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	358						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		AAGACTGAATCGAGCCTGCAT	0.592													16	33	---	---	---	---	PASS
PLA2G4D	283748	broad.mit.edu	37	15	42379558	42379558	+	Silent	SNP	G	A	A	rs140617872	byFrequency	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42379558G>A	uc001zox.2	-	3	290	c.195C>T	c.(193-195)ACC>ACT	p.T65T		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	65	C2.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		GACTGGTGTCGGTGAGCGTCT	0.552													81	197	---	---	---	---	PASS
TMEM62	80021	broad.mit.edu	37	15	43440945	43440945	+	Intron	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43440945C>T	uc001zqr.2	+						TMEM62_uc010bda.2_Intron	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62							integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		ATTTTTCTCCCATCTCAGAAA	0.358													36	112	---	---	---	---	PASS
CEP152	22995	broad.mit.edu	37	15	49048574	49048574	+	Silent	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49048574C>G	uc001zwy.2	-	20	2905	c.2871G>C	c.(2869-2871)CGG>CGC	p.R957R	CEP152_uc001zwz.2_Silent_p.R957R|CEP152_uc001zxa.1_Silent_p.R864R	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	957	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TCCATTCACTCCGAGCCTTAG	0.388													34	103	---	---	---	---	PASS
CYP19A1	1588	broad.mit.edu	37	15	51514634	51514634	+	Missense_Mutation	SNP	A	T	T	rs34896264		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51514634A>T	uc001zyz.3	-	6	791	c.540T>A	c.(538-540)AAT>AAA	p.N180K	CYP19A1_uc001zza.3_Missense_Mutation_p.N180K|CYP19A1_uc001zzb.2_Missense_Mutation_p.N180K|CYP19A1_uc001zzd.2_Missense_Mutation_p.N180K|CYP19A1_uc010bey.1_Missense_Mutation_p.N180K	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	180					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	AGCCCGATTCATTGGTCACCT	0.522													23	63	---	---	---	---	PASS
DMXL2	23312	broad.mit.edu	37	15	51755631	51755631	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51755631A>G	uc002abf.2	-	33	8093	c.7868T>C	c.(7867-7869)GTC>GCC	p.V2623A	DMXL2_uc002abd.2_Missense_Mutation_p.V694A|DMXL2_uc010ufy.1_Missense_Mutation_p.V2624A|DMXL2_uc010bfa.2_Missense_Mutation_p.V1987A	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2623						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CTCTTGAAGGACCTCTTGTTT	0.299													62	150	---	---	---	---	PASS
MYO5A	4644	broad.mit.edu	37	15	52720734	52720734	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52720734C>T	uc002aby.2	-	3	415	c.171G>A	c.(169-171)AAG>AAA	p.K57K	MYO5A_uc002abx.3_Silent_p.K57K|MYO5A_uc010uge.1_Intron	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	57	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GAGGCAGCTCCTTGGTCTTTG	0.458													51	132	---	---	---	---	PASS
VPS13C	54832	broad.mit.edu	37	15	62221838	62221838	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62221838C>A	uc002agz.2	-	51	6222	c.6148G>T	c.(6148-6150)GTA>TTA	p.V2050L	VPS13C_uc002aha.2_Missense_Mutation_p.V2007L|VPS13C_uc002ahb.1_Missense_Mutation_p.V2050L|VPS13C_uc002ahc.1_Missense_Mutation_p.V2007L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2050					protein localization					ovary(2)	2						CTGGCACATACATACAGCTTG	0.368													30	77	---	---	---	---	PASS
SNX1	6642	broad.mit.edu	37	15	64422221	64422221	+	Nonsense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64422221C>G	uc002amv.2	+	9	950	c.914C>G	c.(913-915)TCA>TGA	p.S305*	SNX1_uc010bgv.2_Nonsense_Mutation_p.S19*|SNX1_uc010uio.1_Nonsense_Mutation_p.S305*|SNX1_uc002amw.2_Nonsense_Mutation_p.S305*|SNX1_uc002amx.2_Nonsense_Mutation_p.S240*|SNX1_uc002amy.2_Nonsense_Mutation_p.S234*|SNX1_uc010bgw.2_Nonsense_Mutation_p.S207*	NM_003099	NP_003090	Q13596	SNX1_HUMAN	sorting nexin 1 isoform a	305	BAR.				cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity				0						ATGAATGAATCAGACATTGTG	0.483													3	93	---	---	---	---	PASS
IGDCC4	57722	broad.mit.edu	37	15	65678235	65678235	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65678235G>T	uc002aou.1	-	18	3324	c.3114C>A	c.(3112-3114)GAC>GAA	p.D1038E	IGDCC4_uc002aot.1_Missense_Mutation_p.D626E	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1038	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						CTTCAGCCCTGTCCTCCACGT	0.612											OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	80	---	---	---	---	PASS
DPP8	54878	broad.mit.edu	37	15	65744286	65744286	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65744286G>T	uc002aov.2	-						DPP8_uc002aow.2_Intron|DPP8_uc010uiv.1_Intron|DPP8_uc002aox.2_Intron|DPP8_uc002aoy.2_Intron|DPP8_uc002aoz.2_Intron|DPP8_uc010bhj.2_Intron|DPP8_uc002apa.2_Intron|DPP8_uc010bhi.2_Intron	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1						immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						aaaaaaaaaaGCTTGCACTTA	0.244													5	141	---	---	---	---	PASS
LCTL	197021	broad.mit.edu	37	15	66844498	66844498	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66844498C>T	uc002aqc.2	-	10	1339	c.1207G>A	c.(1207-1209)GGT>AGT	p.G403S	LCTL_uc002aqd.3_Missense_Mutation_p.G230S|LCTL_uc010bhw.2_Missense_Mutation_p.G101S	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	403	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						GGAGGATCACCGTATTGAGTC	0.363													35	101	---	---	---	---	PASS
LBXCOR1	390598	broad.mit.edu	37	15	68122622	68122622	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68122622C>A	uc002aqy.1	+	5	2369	c.2369C>A	c.(2368-2370)GCA>GAA	p.A790E		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	834					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						CCAAGTCCTGCAAATACAGAC	0.557													27	46	---	---	---	---	PASS
CYP1A1	1543	broad.mit.edu	37	15	75014673	75014673	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75014673C>A	uc002ayp.3	-	2	888	c.766G>T	c.(766-768)GAG>TAG	p.E256*	CYP1A1_uc010bjv.2_RNA|CYP1A1_uc010bjw.2_RNA|CYP1A1_uc010bju.2_5'UTR|CYP1A1_uc010bjx.2_5'UTR|CYP1A1_uc002ayq.3_Nonsense_Mutation_p.E256*|CYP1A1_uc010bjy.2_Nonsense_Mutation_p.E256*|CYP1A1_uc010bjz.1_5'UTR	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	256					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	TAGAACTTCTCATTCAGGTCC	0.502									Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				30	48	---	---	---	---	PASS
KIAA1199	57214	broad.mit.edu	37	15	81212548	81212548	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:81212548C>A	uc002bfw.1	+	14	2171	c.1911C>A	c.(1909-1911)ACC>ACA	p.T637T	KIAA1199_uc010unn.1_Silent_p.T637T	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	637										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						AGTCTGGAACCCTCCTCCCCT	0.557													28	93	---	---	---	---	PASS
ADAMTSL3	57188	broad.mit.edu	37	15	84592672	84592672	+	Silent	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84592672A>T	uc002bjz.3	+	17	2228	c.2004A>T	c.(2002-2004)ATA>ATT	p.I668I	ADAMTSL3_uc010bmt.1_Silent_p.I668I|ADAMTSL3_uc010bmu.1_Silent_p.I668I	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	668						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AAGAAGCCATAGCAGTGTGCT	0.443													26	57	---	---	---	---	PASS
OR4F6	390648	broad.mit.edu	37	15	102346675	102346675	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102346675T>A	uc010utr.1	+	1	753	c.753T>A	c.(751-753)TTT>TTA	p.F251L		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTTTGGTCTTTGGGCCATTAA	0.373													84	333	---	---	---	---	PASS
CACNA1H	8912	broad.mit.edu	37	16	1262139	1262139	+	Splice_Site	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1262139G>A	uc002cks.2	+	25	5007	c.4759_splice	c.e25+1	p.S1587_splice	CACNA1H_uc002ckt.2_Splice_Site_p.K1587_splice|CACNA1H_uc002cku.2_Splice_Site_p.S293_splice|CACNA1H_uc010brj.2_Missense_Mutation_p.S293N|CACNA1H_uc002ckv.2_Splice_Site_p.K293_splice	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,						aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGGCGCAGGAGTAAGGCGCTC	0.731													4	7	---	---	---	---	PASS
ABCA3	21	broad.mit.edu	37	16	2369699	2369699	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2369699T>C	uc002cpy.1	-	8	1468	c.756A>G	c.(754-756)GCA>GCG	p.A252A	ABCA3_uc010bsk.1_Silent_p.A252A|ABCA3_uc010bsl.1_Silent_p.A252A	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	252					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GGAAGGGGTCTGCGATGAACG	0.627													9	52	---	---	---	---	PASS
GRIN2A	2903	broad.mit.edu	37	16	9862871	9862871	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:9862871T>A	uc002czo.3	-	12	2980	c.2432A>T	c.(2431-2433)CAG>CTG	p.Q811L	GRIN2A_uc010uym.1_Missense_Mutation_p.Q811L|GRIN2A_uc010uyn.1_Missense_Mutation_p.Q654L|GRIN2A_uc002czr.3_Missense_Mutation_p.Q811L	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	811	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AATGTCCAGCTGGCTGCTCAT	0.557													30	53	---	---	---	---	PASS
GP2	2813	broad.mit.edu	37	16	20331649	20331649	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20331649C>G	uc002dgv.2	-	6	885	c.802G>C	c.(802-804)GAG>CAG	p.E268Q	GP2_uc002dgw.2_Missense_Mutation_p.E265Q|GP2_uc002dgx.2_Missense_Mutation_p.E121Q|GP2_uc002dgy.2_Missense_Mutation_p.E118Q	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	268	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						TTCCTCTCCTCTGTCTGCAAG	0.562													14	116	---	---	---	---	PASS
ACSM5	54988	broad.mit.edu	37	16	20441012	20441012	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20441012G>C	uc002dhe.2	+	8	1161	c.1014G>C	c.(1012-1014)CAG>CAC	p.Q338H		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	338					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						ACCAGTTTCAGAGCCTGAGGC	0.562													23	46	---	---	---	---	PASS
ACSM2A	123876	broad.mit.edu	37	16	20494478	20494478	+	Silent	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20494478C>G	uc010bwe.2	+	14	1847	c.1608C>G	c.(1606-1608)GCC>GCG	p.A536A	ACSM2A_uc002dhf.3_Silent_p.A536A|ACSM2A_uc002dhg.3_Silent_p.A536A|ACSM2A_uc010vay.1_Silent_p.A457A|ACSM2A_uc002dhh.3_Silent_p.A166A	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	536					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CAGTGACAGCCCCATACAAGT	0.483													8	125	---	---	---	---	PASS
ITGAM	3684	broad.mit.edu	37	16	31332938	31332938	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31332938G>T	uc002ebq.2	+	16	2090	c.1992G>T	c.(1990-1992)CGG>CGT	p.R664R	ITGAM_uc002ebr.2_Silent_p.R665R|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_Silent_p.R70R|ITGAM_uc002ebs.1_Silent_p.R70R	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	664	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CACGGGATCGGCTAAGAGAAG	0.532													35	75	---	---	---	---	PASS
ITGAD	3681	broad.mit.edu	37	16	31424300	31424300	+	Intron	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31424300C>A	uc002ebv.1	+						ITGAD_uc010cap.1_Intron	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor						cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						GTAGCGACTCCCCAACATCCT	0.657													30	47	---	---	---	---	PASS
ITGAD	3681	broad.mit.edu	37	16	31424301	31424301	+	Intron	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31424301C>G	uc002ebv.1	+						ITGAD_uc010cap.1_Intron	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor						cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TAGCGACTCCCCAACATCCTG	0.662													29	47	---	---	---	---	PASS
ITGAD	3681	broad.mit.edu	37	16	31429860	31429860	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31429860T>C	uc002ebv.1	+	23	2804	c.2755T>C	c.(2755-2757)TAT>CAT	p.Y919H	ITGAD_uc010cap.1_Missense_Mutation_p.Y920H	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	919	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CCCGGTGAAGTATGCAGTCTA	0.567													40	94	---	---	---	---	PASS
GPT2	84706	broad.mit.edu	37	16	46952628	46952628	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:46952628G>C	uc002eel.2	+	8	1090	c.996G>C	c.(994-996)GAG>GAC	p.E332D	GPT2_uc002eem.2_Missense_Mutation_p.E232D	NM_133443	NP_597700	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase 2 isoform 1	332					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GCAACGTGGAGCTCGCCTCCT	0.612													23	123	---	---	---	---	PASS
ZNF423	23090	broad.mit.edu	37	16	49671670	49671670	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:49671670T>C	uc002efs.2	-	5	1691	c.1393A>G	c.(1393-1395)AAG>GAG	p.K465E	ZNF423_uc010vgn.1_Missense_Mutation_p.K348E	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	465					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GCATGGTTCTTGTGCAGCTTG	0.567													37	65	---	---	---	---	PASS
NOD2	64127	broad.mit.edu	37	16	50759418	50759418	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50759418C>A	uc002egm.1	+	10	3006	c.2901C>A	c.(2899-2901)CTC>CTA	p.L967L	NOD2_uc010vgq.1_Silent_p.L12L	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	967	LRR 7.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				AGAACCATCTCCAGGATGAAG	0.413													30	107	---	---	---	---	PASS
NOD2	64127	broad.mit.edu	37	16	50759419	50759419	+	Nonsense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50759419C>T	uc002egm.1	+	10	3007	c.2902C>T	c.(2902-2904)CAG>TAG	p.Q968*	NOD2_uc010vgq.1_Nonsense_Mutation_p.Q13*	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	968	LRR 7.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				GAACCATCTCCAGGATGAAGG	0.413													32	105	---	---	---	---	PASS
SALL1	6299	broad.mit.edu	37	16	51175285	51175285	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:51175285G>T	uc010vgs.1	-	2	879	c.848C>A	c.(847-849)TCC>TAC	p.S283Y	SALL1_uc010vgr.1_Missense_Mutation_p.S186Y|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	283					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACTTAGCGTGGACAAGGGGTT	0.493													57	94	---	---	---	---	PASS
CES7	221223	broad.mit.edu	37	16	55880745	55880745	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55880745G>A	uc002eip.2	-	12	1580	c.1431C>T	c.(1429-1431)GCC>GCT	p.A477A	CES7_uc002eio.2_Silent_p.A427A|CES7_uc002eiq.2_Silent_p.A238A|CES7_uc002eir.2_Silent_p.A371A	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	477						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		CCTCCTCCGTGGCTCCTTCTG	0.458													68	188	---	---	---	---	PASS
SLC12A3	6559	broad.mit.edu	37	16	56913034	56913034	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56913034C>T	uc010ccm.2	+	10	1259	c.1230C>T	c.(1228-1230)ACC>ACT	p.T410T	SLC12A3_uc002ekd.3_Silent_p.T410T|SLC12A3_uc010ccn.2_Silent_p.T409T	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	410					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	ACACAGTGACCCCTGGCTGGG	0.617													15	20	---	---	---	---	PASS
SLC12A3	6559	broad.mit.edu	37	16	56918127	56918127	+	Intron	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56918127C>T	uc010ccm.2	+						SLC12A3_uc002ekd.3_Intron|SLC12A3_uc010ccn.2_Intron	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3						sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GTGCGCATCTCAGCTGCGGGG	0.602													15	27	---	---	---	---	PASS
DDX19A	55308	broad.mit.edu	37	16	70404234	70404234	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70404234C>T	uc002eyv.2	+	10	1200	c.1129C>T	c.(1129-1131)CGC>TGC	p.R377C	DDX19B_uc010vly.1_Missense_Mutation_p.R378C|DDX19A_uc002eys.2_Missense_Mutation_p.R378C|DDX19A_uc010cfq.1_Missense_Mutation_p.R132C|DDX19A_uc010cfr.2_Missense_Mutation_p.R227C|DDX19A_uc010cfs.2_Missense_Mutation_p.R200C|DDX19A_uc010vlz.1_Missense_Mutation_p.R346C|DDX19A_uc010vma.1_Missense_Mutation_p.R287C	NM_018332	NP_060802	Q9NUU7	DD19A_HUMAN	DDX19-like protein	377	Helicase C-terminal.				mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)				GGTGATTGAGCGCTTCCGAGA	0.612													21	66	---	---	---	---	PASS
CNTNAP4	85445	broad.mit.edu	37	16	76486590	76486590	+	Missense_Mutation	SNP	C	G	G	rs151315964		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:76486590C>G	uc002feu.1	+	10	1642	c.1257C>G	c.(1255-1257)ATC>ATG	p.I419M	CNTNAP4_uc002fev.1_Missense_Mutation_p.I283M|CNTNAP4_uc010chb.1_Missense_Mutation_p.I346M|CNTNAP4_uc002fex.1_Missense_Mutation_p.I422M|CNTNAP4_uc002few.2_Missense_Mutation_p.I394M	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	419	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CAGGGGGTATCCTCCTCTTTC	0.458													35	82	---	---	---	---	PASS
CNTNAP4	85445	broad.mit.edu	37	16	76587757	76587757	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:76587757G>T	uc002feu.1	+	25	4071	c.3686G>T	c.(3685-3687)AGA>ATA	p.R1229I	CNTNAP4_uc002fev.1_Missense_Mutation_p.R1093I|CNTNAP4_uc010chb.1_Missense_Mutation_p.R1156I|CNTNAP4_uc002fex.1_Missense_Mutation_p.R1232I	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1229	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						ATAGATGACAGAGAGCCCCTT	0.358													9	27	---	---	---	---	PASS
KCNG4	93107	broad.mit.edu	37	16	84270616	84270616	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84270616C>T	uc010voc.1	-	2	597	c.476G>A	c.(475-477)AGG>AAG	p.R159K	KCNG4_uc002fhu.1_Missense_Mutation_p.R159K	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	159						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CAGGCAGCACCTCTCCAGGTG	0.667													14	41	---	---	---	---	PASS
OR1A1	8383	broad.mit.edu	37	17	3119289	3119289	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3119289C>A	uc010vrc.1	+	1	375	c.375C>A	c.(373-375)GCC>GCA	p.A125A		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAGCTGTGGCCATCAGCCGCC	0.488													47	61	---	---	---	---	PASS
ZBTB4	57659	broad.mit.edu	37	17	7365586	7365586	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7365586G>T	uc002ghc.3	-	4	2965	c.2715C>A	c.(2713-2715)GAC>GAA	p.D905E	ZBTB4_uc002ghd.3_Missense_Mutation_p.D905E	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	905					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		CCTCCATCCGGTCCCCCTCAC	0.627													15	51	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7577574	7577574	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7577574T>C	uc002gim.2	-	7	901	c.707A>G	c.(706-708)TAC>TGC	p.Y236C	TP53_uc002gig.1_Missense_Mutation_p.Y236C|TP53_uc002gih.2_Missense_Mutation_p.Y236C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y104C|TP53_uc010cng.1_Missense_Mutation_p.Y104C|TP53_uc002gii.1_Missense_Mutation_p.Y104C|TP53_uc010cnh.1_Missense_Mutation_p.Y236C|TP53_uc010cni.1_Missense_Mutation_p.Y236C|TP53_uc002gij.2_Missense_Mutation_p.Y236C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y143C|TP53_uc002gio.2_Missense_Mutation_p.Y104C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	236	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> S (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(46)|p.Y236N(12)|p.Y236*(9)|p.Y236H(9)|p.0?(7)|p.Y236D(6)|p.Y236del(4)|p.Y236S(3)|p.Y236Y(2)|p.Y236fs*4(2)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.Y236fs*5(1)|p.H233fs*6(1)|p.Y236_M237insXX(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTACACATGTAGTTGTAGTG	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	33	---	---	---	---	PASS
GLP2R	9340	broad.mit.edu	37	17	9763275	9763275	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9763275G>C	uc002gmd.1	+	7	782	c.782G>C	c.(781-783)CGC>CCC	p.R261P		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	261	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	ACCTCCTGCCGCTCAGTCCAG	0.572													26	47	---	---	---	---	PASS
MYH4	4622	broad.mit.edu	37	17	10356534	10356534	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10356534T>C	uc002gmn.2	-	24	3157	c.3046A>G	c.(3046-3048)ATG>GTG	p.M1016V	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1016	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCCTCCTCCATCTGCAGGTCA	0.493													57	219	---	---	---	---	PASS
CCDC144A	9720	broad.mit.edu	37	17	16593972	16593972	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:16593972A>G	uc002gqk.1	+	1	334	c.258A>G	c.(256-258)AGA>AGG	p.R86R		NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	86											0						AGCTCCACAGAGCTGCCCGGT	0.632													45	183	---	---	---	---	PASS
PIGS	94005	broad.mit.edu	37	17	26883210	26883210	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26883210C>T	uc002hbo.2	-	10	1528	c.1155G>A	c.(1153-1155)GTG>GTA	p.V385V	PIGS_uc002hbn.2_Silent_p.V377V|PIGS_uc010wap.1_Silent_p.V324V	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	385	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					ACACCTCCATCACTCGCACCA	0.507													89	65	---	---	---	---	PASS
CPD	1362	broad.mit.edu	37	17	28706695	28706695	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28706695G>T	uc002hfb.1	+	1	712	c.697G>T	c.(697-699)GAC>TAC	p.D233Y	CPD_uc010wbo.1_5'Flank|CPD_uc010wbp.1_5'Flank	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	233	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CCCCGCCCTGGACGAGGTGCC	0.706													10	1	---	---	---	---	PASS
NF1	4763	broad.mit.edu	37	17	29556345	29556345	+	Nonsense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29556345T>A	uc002hgg.2	+	21	3045	c.2712T>A	c.(2710-2712)TGT>TGA	p.C904*	NF1_uc002hgh.2_Nonsense_Mutation_p.C904*|NF1_uc010csn.1_Nonsense_Mutation_p.C764*|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	904					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TAATGGTGTGTAACCATGAGA	0.418			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			88	55	---	---	---	---	PASS
TMEM132E	124842	broad.mit.edu	37	17	32955603	32955603	+	Silent	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:32955603G>C	uc002hif.2	+	4	1078	c.750G>C	c.(748-750)GTG>GTC	p.V250V		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	250	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		AGAAGGGTGTGACCCTTTTAG	0.597													42	60	---	---	---	---	PASS
MMP28	79148	broad.mit.edu	37	17	34106035	34106035	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34106035T>A	uc002hjy.1	-	3	495	c.236A>T	c.(235-237)GAC>GTC	p.D79V	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA|MMP28_uc002hka.2_Missense_Mutation_p.D79V	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	79					proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GGTGGCGCGGTCCAACACGCC	0.607													15	51	---	---	---	---	PASS
AATF	26574	broad.mit.edu	37	17	35311101	35311101	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35311101C>T	uc002hni.2	+	4	977	c.726C>T	c.(724-726)ATC>ATT	p.I242I	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	242					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				AAGGAAGGATCAAACTACAAA	0.468													18	176	---	---	---	---	PASS
RAPGEFL1	51195	broad.mit.edu	37	17	38347644	38347644	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38347644G>A	uc010cwu.1	+	9	1284	c.794G>A	c.(793-795)CGC>CAC	p.R265H	RAPGEFL1_uc010wfd.1_Missense_Mutation_p.R201H	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	471	Ras-GEF.				G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGCTGCAGCGCTGCAGCGAG	0.692													4	15	---	---	---	---	PASS
KRTAP4-4	84616	broad.mit.edu	37	17	39316871	39316871	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39316871A>T	uc002hwc.2	-	1	113	c.73T>A	c.(73-75)TAC>AAC	p.Y25N		NM_032524	NP_115913	Q9BYR3	KRA44_HUMAN	keratin associated protein 4.4	25	26 X 5 AA repeats of C-C-[GRQVCH]-[SPT]- [VSTQR].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GTCTGGCAGTAGCTGGGACGG	0.637													27	115	---	---	---	---	PASS
JUP	3728	broad.mit.edu	37	17	39766575	39766575	+	Intron	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39766575G>A	uc010wfs.1	-						KRT16_uc002hxg.3_Intron	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin						adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GAGGGGCCTGGGACTCACTGG	0.622													10	125	---	---	---	---	PASS
STAT5A	6776	broad.mit.edu	37	17	40447725	40447725	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40447725C>T	uc002hzj.1	+	6	1106	c.464C>T	c.(463-465)ACG>ATG	p.T155M	STAT5A_uc010cya.1_Missense_Mutation_p.T155M|STAT5A_uc010cyb.1_Missense_Mutation_p.T155M|STAT5A_uc010cyc.1_Missense_Mutation_p.T125M	NM_003152	NP_003143	P42229	STA5A_HUMAN	signal transducer and activator of transcription	155					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CGACTGGTCACGCAGGACACA	0.557													8	38	---	---	---	---	PASS
AOC3	8639	broad.mit.edu	37	17	41004870	41004870	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41004870A>T	uc002ibv.2	+	1	1670	c.1510A>T	c.(1510-1512)ACT>TCT	p.T504S		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	504	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CTTTGGTGCTACTGGGAAGTA	0.542													92	46	---	---	---	---	PASS
BRCA1	672	broad.mit.edu	37	17	41219706	41219706	+	Missense_Mutation	SNP	C	A	A	rs80357169		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41219706C>A	uc002icq.2	-	16	5225	c.4993G>T	c.(4993-4995)GTG>TTG	p.V1665L	BRCA1_uc010whp.1_Missense_Mutation_p.V514L|BRCA1_uc010whl.1_Missense_Mutation_p.V561L|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.V1594L|BRCA1_uc002icu.2_Missense_Mutation_p.V561L|BRCA1_uc010cyx.2_Missense_Mutation_p.V1618L|BRCA1_uc002ict.2_Missense_Mutation_p.V1686L|BRCA1_uc010whn.1_Missense_Mutation_p.V156L|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.V394L|BRCA1_uc002idc.1_Missense_Mutation_p.V561L|BRCA1_uc010whr.1_Missense_Mutation_p.V515L	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1665	BRCT 1.		V -> M.		androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AACTTGTACACGAGCATCTGA	0.294			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			61	45	---	---	---	---	PASS
MPP3	4356	broad.mit.edu	37	17	41891578	41891578	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41891578C>A	uc002iei.3	-	15	1327	c.1161G>T	c.(1159-1161)CTG>CTT	p.L387L	MPP3_uc002ieh.2_Silent_p.L412L|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	387	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		TCAGAACCACCAGGCGGGGCC	0.627													167	100	---	---	---	---	PASS
ADAM11	4185	broad.mit.edu	37	17	42855529	42855529	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42855529G>C	uc002ihh.2	+	25	2195	c.2195G>C	c.(2194-2196)GGC>GCC	p.G732A	ADAM11_uc010wjd.1_Missense_Mutation_p.G532A|ADAM11_uc002ihi.2_Missense_Mutation_p.A85P	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	732	Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GGTCCCAGCGGCACCAACATC	0.607													8	29	---	---	---	---	PASS
WFIKKN2	124857	broad.mit.edu	37	17	48917193	48917193	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48917193C>A	uc002isv.3	+	2	1238	c.544C>A	c.(544-546)CCC>ACC	p.P182T	WFIKKN2_uc010dbu.2_Missense_Mutation_p.P89T	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	182						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTTCACCTGGCCCAACACCAG	0.627													24	32	---	---	---	---	PASS
CCDC45	90799	broad.mit.edu	37	17	62533868	62533868	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62533868T>G	uc002jem.2	+	20	2495	c.2437T>G	c.(2437-2439)TTT>GTT	p.F813V	CCDC45_uc002jen.2_RNA|CCDC45_uc010wqb.1_Missense_Mutation_p.F649V	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	coiled-coil domain containing 45	813						centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			GCTGGCTTCCTTTCAGTACAG	0.478													6	24	---	---	---	---	PASS
BPTF	2186	broad.mit.edu	37	17	65889725	65889725	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65889725G>T	uc002jgf.2	+	6	2356	c.2295G>T	c.(2293-2295)TGG>TGT	p.W765C	BPTF_uc002jge.2_Missense_Mutation_p.W891C|BPTF_uc010wqm.1_Missense_Mutation_p.W828C	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	891	Interaction with MAZ.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			AGTTCAAATGGAACGGTTCTG	0.423													37	116	---	---	---	---	PASS
BPTF	2186	broad.mit.edu	37	17	65925453	65925453	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65925453C>T	uc002jgf.2	+	17	6061	c.6000C>T	c.(5998-6000)GGC>GGT	p.G2000G	BPTF_uc002jge.2_Silent_p.G2126G	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2126					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTTTTTAAGGCGTTGTTCAAG	0.428													70	68	---	---	---	---	PASS
ABCA6	23460	broad.mit.edu	37	17	67081191	67081191	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67081191C>G	uc002jhw.1	-	32	4337	c.4162G>C	c.(4162-4164)GAC>CAC	p.D1388H		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1388	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					AGCCTCGCGTCCGCTTTCCTG	0.557													28	29	---	---	---	---	PASS
CD300C	10871	broad.mit.edu	37	17	72539114	72539114	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72539114G>T	uc002jky.1	-	3	774	c.413C>A	c.(412-414)ACA>AAA	p.T138K		NM_006678	NP_006669	Q08708	CLM6_HUMAN	CD300C antigen precursor	138	Pro-rich.|Extracellular (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity				0						GCTGGAGGCTGTGGTCGTCCC	0.597													5	132	---	---	---	---	PASS
SAP30BP	29115	broad.mit.edu	37	17	73702537	73702537	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73702537C>T	uc002jpe.2	+	11	917	c.863C>T	c.(862-864)GCC>GTC	p.A288V	SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Missense_Mutation_p.A272V	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	288	Thr-rich.				apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACCACCAGCGCCAGCGGCTCC	0.607													113	139	---	---	---	---	PASS
ITGB4	3691	broad.mit.edu	37	17	73747075	73747075	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73747075C>T	uc002jpg.2	+	30	3863	c.3676C>T	c.(3676-3678)CTG>TTG	p.L1226L	ITGB4_uc002jph.2_Silent_p.L1226L|ITGB4_uc002jpi.3_Silent_p.L1226L|ITGB4_uc002jpj.2_Silent_p.L1226L	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1226	Fibronectin type-III 2.|Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCAGGGCGTCTGGCCTTCAA	0.632													55	222	---	---	---	---	PASS
MGAT5B	146664	broad.mit.edu	37	17	74944914	74944914	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74944914T>C	uc002jti.2	+	16	2503	c.2400T>C	c.(2398-2400)TGT>TGC	p.C800C	MGAT5B_uc002jth.2_Silent_p.C789C|MGAT5B_uc002jtj.2_Silent_p.C196C	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	791	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GCCAGGGCTGTCTGTGAATCC	0.677													3	15	---	---	---	---	PASS
TNRC6C	57690	broad.mit.edu	37	17	76100563	76100563	+	Intron	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76100563C>A	uc002jud.2	+						TNRC6C_uc002juf.2_Intron	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2						gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CTTGCTGTTGCAGGTGCGTCC	0.582													7	5	---	---	---	---	PASS
ANKRD12	23253	broad.mit.edu	37	18	9208692	9208692	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:9208692A>T	uc002knv.2	+	5	599	c.342A>T	c.(340-342)GAA>GAT	p.E114D	ANKRD12_uc010wzn.1_Missense_Mutation_p.E114D|ANKRD12_uc002knw.2_Missense_Mutation_p.E91D|ANKRD12_uc002knx.2_Missense_Mutation_p.E91D	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	114						nucleus				ovary(2)|central_nervous_system(1)	3						CAAAAAAGGAAGCTGGAAATA	0.353													61	57	---	---	---	---	PASS
RNMT	8731	broad.mit.edu	37	18	13759960	13759960	+	Silent	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:13759960C>G	uc002ksk.1	+	11	1480	c.1413C>G	c.(1411-1413)GCC>GCG	p.A471A	RNMT_uc002ksl.1_Silent_p.A471A|RNMT_uc002ksm.1_Silent_p.A471A|RNMT_uc010dlk.2_Intron|RNMT_uc010xae.1_RNA	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	471					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0						TGGTGTTTGCCTTTGAGAAAC	0.353													30	39	---	---	---	---	PASS
ROCK1	6093	broad.mit.edu	37	18	18571141	18571141	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:18571141C>T	uc002kte.2	-	18	3080	c.2139G>A	c.(2137-2139)ATG>ATA	p.M713I		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	713	Glu-rich.|Interaction with FHOD1.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					ACTTACCACACATTGCCACAG	0.318													217	164	---	---	---	---	PASS
MIB1	57534	broad.mit.edu	37	18	19424132	19424132	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19424132A>T	uc002ktq.2	+	15	2129	c.2129A>T	c.(2128-2130)CAC>CTC	p.H710L	MIB1_uc002ktp.2_Missense_Mutation_p.H349L	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	710	ANK 9.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			CTAAGGCATCACACTTTGTCT	0.468													50	280	---	---	---	---	PASS
CDH2	1000	broad.mit.edu	37	18	25562912	25562912	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:25562912T>A	uc002kwg.2	-	14	2804	c.2345A>T	c.(2344-2346)GAC>GTC	p.D782V	CDH2_uc010xbn.1_Missense_Mutation_p.D751V	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	782	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GCTCACCTGGTCTTCTTCTCC	0.323													9	350	---	---	---	---	PASS
DSC3	1825	broad.mit.edu	37	18	28612202	28612202	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28612202A>T	uc002kwj.3	-	2	265	c.110T>A	c.(109-111)CTT>CAT	p.L37H	DSC3_uc002kwi.3_Missense_Mutation_p.L37H	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	37					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			AGGTACATTAAGTATCACCTT	0.294													6	310	---	---	---	---	PASS
DSG4	147409	broad.mit.edu	37	18	28966736	28966736	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28966736C>A	uc002kwq.2	+	3	305	c.170C>A	c.(169-171)GCC>GAC	p.A57D	DSG4_uc002kwr.2_Missense_Mutation_p.A57D	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	57	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTTGCCGCAGCCTGTCGAGAA	0.448													53	314	---	---	---	---	PASS
C18orf34	374864	broad.mit.edu	37	18	30926304	30926304	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30926304G>C	uc002kxn.2	-	8	671	c.529C>G	c.(529-531)CTA>GTA	p.L177V	C18orf34_uc010xbr.1_Missense_Mutation_p.L177V|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.L177V|C18orf34_uc002kxp.2_Missense_Mutation_p.L177V	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	177	Potential.									ovary(1)	1						TCAGTTTCTAGACTTTTAATG	0.363													22	331	---	---	---	---	PASS
ZNF236	7776	broad.mit.edu	37	18	74592249	74592249	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:74592249G>T	uc002lmi.2	+	8	1357	c.1159G>T	c.(1159-1161)GGC>TGC	p.G387C	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Missense_Mutation_p.G387C	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	387					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CATCACAGTGGGCATCAACCA	0.597													13	19	---	---	---	---	PASS
CIRBP	1153	broad.mit.edu	37	19	1269900	1269900	+	Intron	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1269900G>A	uc002lrr.3	+						C19orf23_uc010xgk.1_RNA|CIRBP_uc010dsg.1_Intron|CIRBP_uc002lrt.2_Intron|CIRBP_uc010xgl.1_Intron|CIRBP_uc002lrv.3_Intron|CIRBP_uc002lru.2_Intron	NM_001280	NP_001271	Q14011	CIRBP_HUMAN	cold inducible RNA binding protein						mRNA stabilization|positive regulation of translation|response to cold|response to UV|stress granule assembly	nucleoplasm|stress granule	mRNA 3'-UTR binding|nucleotide binding|protein binding|SSU rRNA binding|translation repressor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTAGGCGTGGCCCGTTCTAG	0.542													16	25	---	---	---	---	PASS
TCF3	6929	broad.mit.edu	37	19	1612236	1612236	+	Intron	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1612236C>A	uc002ltr.2	-						TCF3_uc002ltn.2_Missense_Mutation_p.V47F|TCF3_uc002lto.2_Intron|TCF3_uc002ltt.3_Missense_Mutation_p.V595F|TCF3_uc002ltq.2_Intron|TCF3_uc002lts.1_Missense_Mutation_p.V510F	NM_003200	NP_003191	P15923	TFE2_HUMAN	transcription factor 3 isoform E12						B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGATGACCTGCACGGCC	0.657			T	PBX1|HLF|TFPT	pre B-ALL								20	35	---	---	---	---	PASS
ZFR2	23217	broad.mit.edu	37	19	3823291	3823291	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3823291C>G	uc002lyw.2	-	8	1336	c.1324G>C	c.(1324-1326)GCG>CCG	p.A442P	ZFR2_uc010xhx.1_RNA	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	442						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		GAGCAGCCCGCGGGAGCTTCC	0.632													7	164	---	---	---	---	PASS
C3	718	broad.mit.edu	37	19	6714353	6714353	+	Intron	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6714353C>G	uc002mfm.2	-							NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor						complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TCCTCAAGAACCTGACATACT	0.617													11	52	---	---	---	---	PASS
HNRNPM	4670	broad.mit.edu	37	19	8550724	8550724	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8550724G>C	uc010dwe.2	+	14	1492	c.1412G>C	c.(1411-1413)CGC>CCC	p.R471P	HNRNPM_uc010xke.1_Missense_Mutation_p.R417P|HNRNPM_uc010dwd.2_Missense_Mutation_p.R432P|HNRNPM_uc002mka.2_Missense_Mutation_p.R336P|HNRNPM_uc002mkb.1_5'Flank	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	471	10.|27 X 6 AA repeats of [GEVSTPAN]-[ILMV]- [DE]-[RH]-[MLVI]-[GAV].				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						AGCATTGAGCGCATGGGCCAG	0.687													23	69	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9058345	9058345	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9058345C>A	uc002mkp.2	-	3	29305	c.29101G>T	c.(29101-29103)GAG>TAG	p.E9701*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9703	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGGTCATCTCTGAGTGTGAA	0.478													12	56	---	---	---	---	PASS
OR7E24	26648	broad.mit.edu	37	19	9362505	9362505	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9362505C>A	uc002mlb.1	+	1	786	c.786C>A	c.(784-786)CAC>CAA	p.H262Q		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	262	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTGGCTCTCACCTGGCAGTTG	0.458													11	28	---	---	---	---	PASS
COL5A3	50509	broad.mit.edu	37	19	10114712	10114712	+	Intron	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10114712C>A	uc002mmq.1	-							NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GAGTCCCTCACTCACCACTGT	0.577													19	74	---	---	---	---	PASS
FBXW9	84261	broad.mit.edu	37	19	12800594	12800594	+	Missense_Mutation	SNP	C	A	A	rs62108390		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12800594C>A	uc010dyx.2	-	7	1187	c.1187G>T	c.(1186-1188)GGC>GTC	p.G396V	FBXW9_uc010xmp.1_RNA|uc002mul.1_3'UTR|FBXW9_uc002mum.1_Missense_Mutation_p.G376V|FBXW9_uc002mun.1_Missense_Mutation_p.G213V	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	406	WD 5.						protein binding			ovary(1)	1						CTGGAAGCAGCCGTTGCGGTT	0.657													23	66	---	---	---	---	PASS
CC2D1A	54862	broad.mit.edu	37	19	14023230	14023230	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14023230G>C	uc002mxo.2	+	3	590	c.291G>C	c.(289-291)TTG>TTC	p.L97F	CC2D1A_uc002mxn.2_Intron|CC2D1A_uc002mxp.2_Missense_Mutation_p.L97F|CC2D1A_uc010dzh.2_5'Flank	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	97					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			AGGACGACTTGGAGGCTGATG	0.627													9	23	---	---	---	---	PASS
CYP4F8	11283	broad.mit.edu	37	19	15726522	15726522	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15726522C>T	uc002nbi.2	+	2	159	c.95C>T	c.(94-96)GCC>GTC	p.A32V	CYP4F8_uc010xoi.1_Missense_Mutation_p.A32V|CYP4F8_uc010xoj.1_5'UTR	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	32	Helical; (Potential).				prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TGGCTCCTGGCCCGCATCCTG	0.672													24	43	---	---	---	---	PASS
CYP4F11	57834	broad.mit.edu	37	19	16045010	16045010	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16045010G>T	uc002nbu.2	-						CYP4F11_uc010eab.1_Intron|CYP4F11_uc002nbt.2_Intron	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide						inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						CCGTCCTGCTGACAAACTCAC	0.592													16	39	---	---	---	---	PASS
CYP4F11	57834	broad.mit.edu	37	19	16045011	16045011	+	Intron	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16045011A>T	uc002nbu.2	-						CYP4F11_uc010eab.1_Intron|CYP4F11_uc002nbt.2_Intron	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide						inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						CGTCCTGCTGACAAACTCACC	0.592													18	40	---	---	---	---	PASS
NR2F6	2063	broad.mit.edu	37	19	17355849	17355849	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17355849C>G	uc002nfq.2	-	1	303	c.181G>C	c.(181-183)GAC>CAC	p.D61H		NM_005234	NP_005225	P10588	NR2F6_HUMAN	nuclear receptor subfamily 2, group F, member 6	61	Nuclear receptor.|NR C4-type.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding				0						CTCGACTTGTCCCCGCACACC	0.692													4	12	---	---	---	---	PASS
ANKLE1	126549	broad.mit.edu	37	19	17396327	17396327	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17396327C>A	uc002nga.2	+	7	1740	c.1464C>A	c.(1462-1464)GGC>GGA	p.G488G	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Silent_p.G484G|ANKLE1_uc010xpn.1_Silent_p.G516G|ANKLE1_uc002nfy.2_Silent_p.G451G|ANKLE1_uc002nfz.2_Silent_p.G194G	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	488						nuclear envelope					0						TCTACGTGGGCAAAGGGACGA	0.612													40	175	---	---	---	---	PASS
UNC13A	23025	broad.mit.edu	37	19	17756582	17756582	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17756582C>A	uc002nhd.2	-	19	2521	c.2521G>T	c.(2521-2523)GTG>TTG	p.V841L		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	753	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						CTCTGTTTCACGCGGGATTTG	0.587													10	20	---	---	---	---	PASS
GDF1	2657	broad.mit.edu	37	19	18989838	18989838	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18989838G>T	uc002nki.1	-	6	983	c.911C>A	c.(910-912)GCG>GAG	p.A304E	LASS1_uc002nkj.2_Missense_Mutation_p.A304E|LASS1_uc010ebx.2_Missense_Mutation_p.A206E	NM_021267	NP_067090	P27539	GDF1_HUMAN	LAG1 homolog, ceramide synthase 1 isoform 1	Error:Variant_position_missing_in_P27539_after_alignment					growth	extracellular space	cytokine activity|growth factor activity				0						GGCTGCAAACGCCACGATGTA	0.642													20	22	---	---	---	---	PASS
HAPLN4	404037	broad.mit.edu	37	19	19369365	19369365	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19369365A>G	uc002nmb.2	-	4	839	c.784T>C	c.(784-786)TAC>CAC	p.Y262H	HAPLN4_uc002nmc.2_Missense_Mutation_p.Y262H	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	262	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			AAGGCGTCGTAGCGTTCCTCG	0.692													20	41	---	---	---	---	PASS
ZNF536	9745	broad.mit.edu	37	19	30935560	30935560	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30935560T>A	uc002nsu.1	+	2	1229	c.1091T>A	c.(1090-1092)ATG>AAG	p.M364K	ZNF536_uc010edd.1_Missense_Mutation_p.M364K	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	364	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AAGGGTCACATGCGCAAGCAC	0.627													58	139	---	---	---	---	PASS
SCN1B	6324	broad.mit.edu	37	19	35530610	35530610	+	3'UTR	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35530610G>T	uc002nxp.2	+	5					SCN1B_uc010xsg.1_3'UTR|HPN_uc002nxq.1_5'Flank|HPN_uc002nxr.1_5'Flank|HPN_uc002nxs.1_5'Flank	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta						axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GAATAGCCCTGGTAAGGCGGA	0.622													8	34	---	---	---	---	PASS
ZNF527	84503	broad.mit.edu	37	19	37879573	37879573	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37879573G>T	uc010efk.1	+	5	733	c.622G>T	c.(622-624)GAA>TAA	p.E208*	ZNF527_uc002ogf.3_Nonsense_Mutation_p.E176*|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGTCATAATTGAATATAAAAG	0.323													14	102	---	---	---	---	PASS
ITPKC	80271	broad.mit.edu	37	19	41231345	41231345	+	Splice_Site	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41231345G>T	uc002oot.2	+	2	1288	c.1255_splice	c.e2+1	p.G419_splice		NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C							cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GGACATGCTGGTAAGTGGGGT	0.428													55	80	---	---	---	---	PASS
ZFP112	7771	broad.mit.edu	37	19	44832207	44832207	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44832207G>T	uc010ejj.2	-	5	2234	c.2121C>A	c.(2119-2121)TAC>TAA	p.Y707*	ZFP112_uc002ozc.3_Nonsense_Mutation_p.Y701*|ZFP112_uc010xwy.1_Nonsense_Mutation_p.Y724*|ZFP112_uc010xwz.1_Nonsense_Mutation_p.Y706*	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	707	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GACTCTGAAGGTATGATCTCT	0.458													16	112	---	---	---	---	PASS
GEMIN7	79760	broad.mit.edu	37	19	45593723	45593723	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45593723G>T	uc002pap.1	+	3	502	c.351G>T	c.(349-351)GCG>GCT	p.A117A	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Silent_p.A117A|GEMIN7_uc002par.1_Silent_p.A117A	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	117					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		AAGCAGAGGCGCTGCTCCGAT	0.527													24	55	---	---	---	---	PASS
RSPH6A	81492	broad.mit.edu	37	19	46307718	46307718	+	Missense_Mutation	SNP	C	G	G	rs139803225		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46307718C>G	uc002pdm.2	-	3	1588	c.1445G>C	c.(1444-1446)CGG>CCG	p.R482P	RSPH6A_uc002pdl.2_Missense_Mutation_p.R218P	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	482						intracellular				ovary(1)|central_nervous_system(1)	2						TATCTGGGCCCGCAGGTAGTT	0.622													14	33	---	---	---	---	PASS
SLC1A5	6510	broad.mit.edu	37	19	47285696	47285696	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47285696G>T	uc002pfs.2	-	4	1388	c.768C>A	c.(766-768)ATC>ATA	p.I256I	SLC1A5_uc010xyh.1_Silent_p.I54I|SLC1A5_uc002pfq.2_Silent_p.I80I|SLC1A5_uc002pfr.2_Silent_p.I28I	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	256					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	TGAAGAAGCGGATAAGCAGCT	0.602													60	118	---	---	---	---	PASS
CCDC155	147872	broad.mit.edu	37	19	49912443	49912443	+	Intron	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49912443G>C	uc002pnm.1	+						CCDC155_uc010emx.1_Intron	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155							integral to membrane	calcium ion binding			ovary(1)|central_nervous_system(1)	2						CCTCCTTCCTGTGTGGCCAGG	0.647													15	20	---	---	---	---	PASS
MYH14	79784	broad.mit.edu	37	19	50785099	50785099	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50785099G>T	uc002prr.1	+	31	4463	c.4416G>T	c.(4414-4416)CAG>CAT	p.Q1472H	MYH14_uc010enu.1_Missense_Mutation_p.Q1513H|MYH14_uc002prq.1_Missense_Mutation_p.Q1480H|MYH14_uc010ycb.1_Intron|MYH14_uc002prs.1_5'Flank	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1472	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		AGTTTGACCAGGTGGGGCACC	0.617													6	23	---	---	---	---	PASS
ZNF808	388558	broad.mit.edu	37	19	53058070	53058070	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53058070G>T	uc010epq.1	+	5	2078	c.1901G>T	c.(1900-1902)TGG>TTG	p.W634L	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	634	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		GCTTTCACGTGGAATTCACAG	0.403													22	51	---	---	---	---	PASS
ZNF808	388558	broad.mit.edu	37	19	53058071	53058071	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53058071G>T	uc010epq.1	+	5	2079	c.1902G>T	c.(1900-1902)TGG>TGT	p.W634C	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	634	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CTTTCACGTGGAATTCACAGC	0.398													22	50	---	---	---	---	PASS
ZNF415	55786	broad.mit.edu	37	19	53612393	53612393	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53612393C>A	uc002qax.2	-	7	1398	c.1049G>T	c.(1048-1050)TGT>TTT	p.C350F	ZNF415_uc002qat.2_Missense_Mutation_p.C314F|ZNF415_uc002qaw.2_Missense_Mutation_p.C302F|ZNF415_uc010yds.1_Missense_Mutation_p.C302F|ZNF415_uc010ydt.1_Missense_Mutation_p.C302F|ZNF415_uc002qau.2_Missense_Mutation_p.C289F|ZNF415_uc002qav.2_Missense_Mutation_p.C314F|ZNF415_uc002qba.2_Missense_Mutation_p.C72F|ZNF415_uc002qay.2_Missense_Mutation_p.C289F|ZNF415_uc002qaz.2_Missense_Mutation_p.C350F	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	350	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		ACACTCATAACATTTGTAAGG	0.403													8	76	---	---	---	---	PASS
ZNF813	126017	broad.mit.edu	37	19	53995112	53995112	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53995112T>G	uc002qbu.2	+	4	1754	c.1626T>G	c.(1624-1626)CAT>CAG	p.H542Q	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	542	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CACATCATCATAGACTTCATA	0.383													4	44	---	---	---	---	PASS
ZNF331	55422	broad.mit.edu	37	19	54080374	54080374	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54080374A>G	uc002qbx.1	+	7	1994	c.560A>G	c.(559-561)TAC>TGC	p.Y187C	ZNF331_uc002qby.1_Missense_Mutation_p.Y187C|ZNF331_uc002qbz.1_Missense_Mutation_p.Y187C|ZNF331_uc002qca.1_Missense_Mutation_p.Y187C|ZNF331_uc010eqr.1_Missense_Mutation_p.Y187C|ZNF331_uc002qcb.1_Missense_Mutation_p.Y187C|ZNF331_uc002qcc.1_Missense_Mutation_p.Y187C|ZNF331_uc002qcd.1_Missense_Mutation_p.Y187C	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	187	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		GAGAAGCCCTACGAATGTAAA	0.418			T	?	follicular thyroid adenoma								41	79	---	---	---	---	PASS
NLRP12	91662	broad.mit.edu	37	19	54312830	54312830	+	Intron	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54312830G>C	uc002qch.3	-						NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Intron|NLRP12_uc002qcj.3_Intron|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform						negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GGATACCCCAGGGATACTTAC	0.433													4	34	---	---	---	---	PASS
LILRB3	11025	broad.mit.edu	37	19	54720984	54720984	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54720984T>C	uc002qef.1	-	13	1985	c.1874A>G	c.(1873-1875)TAC>TGC	p.Y625C	LILRB3_uc002qee.1_Missense_Mutation_p.Y626C|LILRB3_uc002qeh.1_Missense_Mutation_p.Y625C|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Missense_Mutation_p.Y625C|LILRA6_uc002qek.1_Missense_Mutation_p.Y626C|LILRB3_uc010erh.1_Missense_Mutation_p.Y642C|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Missense_Mutation_p.Y625C|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.Y626C|LILRB3_uc002qep.1_Missense_Mutation_p.Y626C|LILRB3_uc002qeq.1_Missense_Mutation_p.Y625C|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.Y626C	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	625	ITIM motif 3.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGAGTGGCGTAGATGCTGGG	0.627													7	59	---	---	---	---	PASS
LILRB5	10990	broad.mit.edu	37	19	54760404	54760404	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54760404C>A	uc002qex.2	-	3	414	c.303G>T	c.(301-303)GAG>GAT	p.E101D	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.E101D|LILRB5_uc002qey.2_Missense_Mutation_p.E101D|LILRB5_uc002qez.2_Missense_Mutation_p.E101D|LILRB5_uc002qfa.1_Missense_Mutation_p.E91D|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	101	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGCAGGGGTCTCATAGTAGC	0.627													78	123	---	---	---	---	PASS
LILRA2	11027	broad.mit.edu	37	19	55085768	55085768	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55085768G>T	uc002qgg.3	+	3	160	c.71G>T	c.(70-72)GGG>GTG	p.G24V	LILRA2_uc010ern.2_Missense_Mutation_p.G24V|LILRA2_uc002qgf.2_Missense_Mutation_p.G24V|LILRA2_uc010yfe.1_Missense_Mutation_p.G24V|LILRA2_uc010yff.1_Missense_Mutation_p.G12V|LILRA2_uc010ero.2_Missense_Mutation_p.G12V|LILRA2_uc010yfg.1_Missense_Mutation_p.G24V	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	24	Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TTCCTTCCAGGGCACCTCCCC	0.597													17	137	---	---	---	---	PASS
LILRA2	11027	broad.mit.edu	37	19	55086322	55086322	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55086322A>G	uc002qgg.3	+	4	566	c.477A>G	c.(475-477)GAA>GAG	p.E159E	LILRA2_uc010ern.2_Silent_p.E159E|LILRA2_uc002qgf.2_Silent_p.E159E|LILRA2_uc010yfe.1_Silent_p.E159E|LILRA2_uc010yff.1_Silent_p.E147E|LILRA2_uc010ero.2_Silent_p.E147E|LILRA2_uc010yfg.1_Silent_p.E159E	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	159	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		AGGAAGGAGAAGATGAACACC	0.602													43	88	---	---	---	---	PASS
EPN1	29924	broad.mit.edu	37	19	56206164	56206164	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56206164G>T	uc002qlw.2	+	10	1679	c.1337G>T	c.(1336-1338)GGA>GTA	p.G446V	EPN1_uc002qlv.2_Missense_Mutation_p.G420V|EPN1_uc010etd.2_Missense_Mutation_p.G445V|EPN1_uc002qlx.2_Missense_Mutation_p.G532V	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	446	Ala/Gly/Pro-rich.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		GGGGTCAGGGGATCTCTGGCT	0.677													4	9	---	---	---	---	PASS
ZNF470	388566	broad.mit.edu	37	19	57089731	57089731	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57089731G>C	uc002qnl.3	+	6	2610	c.1934G>C	c.(1933-1935)GGA>GCA	p.G645A	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	645					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ATTCATACAGGAGAGAAACCT	0.418													33	32	---	---	---	---	PASS
PEG3	5178	broad.mit.edu	37	19	57325205	57325205	+	Silent	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57325205A>T	uc002qnu.2	-	7	4956	c.4605T>A	c.(4603-4605)CCT>CCA	p.P1535P	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.P1506P|PEG3_uc002qnv.2_Silent_p.P1535P|PEG3_uc002qnw.2_Silent_p.P1411P|PEG3_uc002qnx.2_Silent_p.P1409P|PEG3_uc010etr.2_Silent_p.P1535P	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1535					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGGCATTTGCAGGCTCAAATA	0.478													4	129	---	---	---	---	PASS
ZNF17	7565	broad.mit.edu	37	19	57931891	57931891	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57931891C>A	uc002qoo.1	+	3	1262	c.1031C>A	c.(1030-1032)GCA>GAA	p.A344E	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Missense_Mutation_p.A346E	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		TACAGTTCAGCACTCATTAGA	0.413													4	115	---	---	---	---	PASS
ZNF324B	388569	broad.mit.edu	37	19	58967702	58967702	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58967702A>G	uc002qsv.1	+	4	1498	c.1391A>G	c.(1390-1392)AAG>AGG	p.K464R	ZNF324B_uc002qsu.1_Missense_Mutation_p.K454R|ZNF324B_uc010euq.1_Missense_Mutation_p.K464R	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	464	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GGTTTCGCCAAGGGCGCCGTG	0.692													14	79	---	---	---	---	PASS
TRIB3	57761	broad.mit.edu	37	20	377279	377279	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:377279G>T	uc002wdm.2	+	4	1528	c.1022G>T	c.(1021-1023)GGG>GTG	p.G341V	TRIB3_uc002wdn.2_Missense_Mutation_p.G368V	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	341					apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GATGGACTGGGGCTGGACGAA	0.612													34	74	---	---	---	---	PASS
SNRPB	6628	broad.mit.edu	37	20	2446372	2446372	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2446372C>G	uc002wfz.1	-	3	412	c.249G>C	c.(247-249)GAG>GAC	p.E83D	SNRPB_uc002wga.1_Missense_Mutation_p.E83D|SNRPB_uc010zpv.1_Missense_Mutation_p.E4D|SNRPB_uc002wgb.2_Missense_Mutation_p.E83D|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	83					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						GAGGAGGTCCCTCTACTGTCA	0.423													40	95	---	---	---	---	PASS
CPXM1	56265	broad.mit.edu	37	20	2776343	2776343	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2776343A>T	uc002wgu.2	-	11	1686	c.1622T>A	c.(1621-1623)CTG>CAG	p.L541Q	CPXM1_uc010gas.2_Intron	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	541					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						CTGCATGGCCAGATTACTGCC	0.632													14	60	---	---	---	---	PASS
SEL1L2	80343	broad.mit.edu	37	20	13830833	13830833	+	Intron	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13830833T>A	uc010gcf.2	-						SEL1L2_uc002woq.3_Intron|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_Intron	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor							integral to membrane	binding			ovary(2)	2						CAAGACAAACTTACATTAAAA	0.478													28	44	---	---	---	---	PASS
SLC24A3	57419	broad.mit.edu	37	20	19665875	19665875	+	Silent	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:19665875A>T	uc002wrl.2	+	12	1391	c.1194A>T	c.(1192-1194)ACA>ACT	p.T398T		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	398	Cytoplasmic (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						TGAATGGGACACGGAGGGACG	0.408													18	53	---	---	---	---	PASS
ACSS1	84532	broad.mit.edu	37	20	25002053	25002053	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25002053A>G	uc002wub.2	-	6	1958	c.1080T>C	c.(1078-1080)TTT>TTC	p.F360F	ACSS1_uc002wuc.2_Silent_p.F360F|ACSS1_uc010gdc.2_Intron|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Silent_p.F277F	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	360					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGGTGCTCTCAAAAAGGACGC	0.562													18	41	---	---	---	---	PASS
DEFB118	117285	broad.mit.edu	37	20	29956507	29956507	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:29956507C>T	uc002wvr.2	+	1	80	c.54C>T	c.(52-54)ATC>ATT	p.I18I		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	18					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCCAAGTGATCCCAGGTAATC	0.498													26	78	---	---	---	---	PASS
GSS	2937	broad.mit.edu	37	20	33517381	33517381	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33517381T>C	uc002xbg.2	-	12	1204	c.1124A>G	c.(1123-1125)TAT>TGT	p.Y375C	GSS_uc010zun.1_Missense_Mutation_p.Y247C|GSS_uc010zuo.1_Missense_Mutation_p.Y264C|GSS_uc010zup.1_Missense_Mutation_p.Y306C|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Missense_Mutation_p.Y105C	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	375		ATP.			nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	TTCCTCCCCATATAGGTTGTT	0.537													74	218	---	---	---	---	PASS
C20orf117	140710	broad.mit.edu	37	20	35467803	35467803	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35467803C>A	uc002xgd.1	-	2	342	c.15G>T	c.(13-15)CGG>CGT	p.R5R		NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	5											0		Myeloproliferative disorder(115;0.00874)				TATAGACGTCCCGCATCTCCA	0.632													24	40	---	---	---	---	PASS
RALGAPB	57148	broad.mit.edu	37	20	37169808	37169808	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37169808A>T	uc002xiw.2	+	18	2944	c.2687A>T	c.(2686-2688)AAG>ATG	p.K896M	RALGAPB_uc002xix.2_Missense_Mutation_p.K892M|RALGAPB_uc002xiy.1_Missense_Mutation_p.K896M|RALGAPB_uc002xiz.2_Missense_Mutation_p.K674M|RALGAPB_uc002xja.1_Missense_Mutation_p.K623M	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	896					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						ATGAGGGTAAAGGATGCTGCT	0.458													41	76	---	---	---	---	PASS
PPP1R16B	26051	broad.mit.edu	37	20	37524217	37524217	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37524217G>T	uc002xje.2	+	4	520	c.331G>T	c.(331-333)GAC>TAC	p.D111Y	PPP1R16B_uc010ggc.2_Missense_Mutation_p.D111Y	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	111	ANK 1.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GTGCTGCATCGACAACTTTGA	0.607													11	30	---	---	---	---	PASS
ZSWIM3	140831	broad.mit.edu	37	20	44506234	44506234	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44506234G>T	uc002xqd.2	+	2	1240	c.1037G>T	c.(1036-1038)AGC>ATC	p.S346I	ZSWIM3_uc010zxg.1_Missense_Mutation_p.S340I	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	346							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				TCTGAAGCCAGCCTGAAAAAT	0.512													56	93	---	---	---	---	PASS
PREX1	57580	broad.mit.edu	37	20	47273723	47273723	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47273723C>A	uc002xtw.1	-	18	2001	c.1978G>T	c.(1978-1980)GCT>TCT	p.A660S	PREX1_uc002xtv.1_5'Flank	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	660	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			TGCAGGCCAGCCACCTGGGTA	0.567											OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	53	---	---	---	---	PASS
DIDO1	11083	broad.mit.edu	37	20	61525784	61525784	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61525784G>A	uc002ydr.1	-	11	2817	c.2553C>T	c.(2551-2553)CTC>CTT	p.L851L	DIDO1_uc002yds.1_Silent_p.L851L|DIDO1_uc002ydt.1_Silent_p.L851L|DIDO1_uc002ydu.1_Silent_p.L851L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	851					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TTTTACAGTTGAGATCGAAGA	0.502													37	95	---	---	---	---	PASS
TPTE	7179	broad.mit.edu	37	21	10934070	10934070	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10934070T>A	uc002yip.1	-	16	1275	c.907A>T	c.(907-909)ATG>TTG	p.M303L	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.M285L|TPTE_uc002yir.1_Missense_Mutation_p.M265L|TPTE_uc010gkv.1_Missense_Mutation_p.M165L	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	303	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCATCAATCATGATTCTAACG	0.313													17	537	---	---	---	---	PASS
TPTE	7179	broad.mit.edu	37	21	10970069	10970069	+	Intron	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10970069G>T	uc002yip.1	-						TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGACTAGTGGATGATAAGAG	0.373													38	157	---	---	---	---	PASS
TIAM1	7074	broad.mit.edu	37	21	32617976	32617976	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:32617976C>A	uc002yow.1	-	7	1884	c.1412G>T	c.(1411-1413)GGA>GTA	p.G471V	TIAM1_uc011adk.1_Missense_Mutation_p.G471V|TIAM1_uc011adl.1_Missense_Mutation_p.G471V|TIAM1_uc002yox.1_Missense_Mutation_p.G79V	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	471	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TAGCGTGCATCCTGAGGAAAC	0.517													15	18	---	---	---	---	PASS
SETD4	54093	broad.mit.edu	37	21	37431134	37431134	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37431134C>G	uc002yuw.1	-	1	1426	c.53G>C	c.(52-54)GGA>GCA	p.G18A	SETD4_uc002yux.1_5'UTR|SETD4_uc002yuu.2_RNA|SETD4_uc002yuv.2_Missense_Mutation_p.G18A|SETD4_uc002yuy.2_Missense_Mutation_p.G18A|SETD4_uc002yuz.2_5'UTR|SETD4_uc002yva.2_5'UTR	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	18										large_intestine(1)|ovary(1)	2						TTCAGAACTTCCGCAGAGTTT	0.343													42	261	---	---	---	---	PASS
HLCS	3141	broad.mit.edu	37	21	38309018	38309018	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38309018C>G	uc010gnb.2	-	4	1928	c.727G>C	c.(727-729)GTG>CTG	p.V243L	HLCS_uc002yvs.2_Missense_Mutation_p.V243L|HLCS_uc010gnc.1_Missense_Mutation_p.V390L	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	243					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	AGGCCCAACACCTTCCCTCCC	0.522													5	49	---	---	---	---	PASS
WDR4	10785	broad.mit.edu	37	21	44296822	44296822	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44296822C>T	uc002zci.2	-	2	218	c.145G>A	c.(145-147)GAA>AAA	p.E49K	WDR4_uc002zck.1_Missense_Mutation_p.E49K|WDR4_uc002zcl.1_5'UTR|WDR4_uc010gpg.1_Missense_Mutation_p.E49K|WDR4_uc011aew.1_5'UTR|WDR4_uc010gph.1_5'UTR	NM_033661	NP_387510	P57081	WDR4_HUMAN	WD repeat domain 4 protein	49					tRNA modification	cytoplasm|nucleoplasm	protein binding			ovary(1)	1				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		CCTTTATTTTCTTGTGACTTC	0.393													20	58	---	---	---	---	PASS
NDUFV3	4731	broad.mit.edu	37	21	44326969	44326969	+	Intron	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44326969A>T	uc002zcn.2	+						NDUFV3_uc002zcm.2_Intron	NM_001001503	NP_001001503	P56181	NDUV3_HUMAN	NADH-ubiquinone oxidoreductase flavoprotein 3						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			ovary(2)	2				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	CACCACACCGAAGATACTCAC	0.393													6	53	---	---	---	---	PASS
ITGB2	3689	broad.mit.edu	37	21	46320303	46320303	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46320303C>A	uc002zgd.2	-	6	873	c.829G>T	c.(829-831)GCC>TCC	p.A277S	ITGB2_uc002zge.2_Missense_Mutation_p.A277S|ITGB2_uc002zgf.3_Missense_Mutation_p.A277S|ITGB2_uc011afl.1_Missense_Mutation_p.A199S|ITGB2_uc010gpw.2_Missense_Mutation_p.A220S|ITGB2_uc002zgg.2_Missense_Mutation_p.A277S	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	277	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GTCAGGATGGCGCCCAGCTTC	0.627													9	55	---	---	---	---	PASS
PCBP3	54039	broad.mit.edu	37	21	47350716	47350716	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47350716A>T	uc002zhq.1	+	11	938	c.813A>T	c.(811-813)TTA>TTT	p.L271F	PCBP3_uc010gqb.2_Missense_Mutation_p.L271F|PCBP3_uc002zhp.1_Intron|PCBP3_uc002zhs.1_Missense_Mutation_p.L245F|PCBP3_uc002zhr.1_Missense_Mutation_p.L270F|PCBP3_uc002zht.1_Missense_Mutation_p.L261F	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	271					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		agctgcctttacactcctccg	0.164													4	43	---	---	---	---	PASS
COL6A1	1291	broad.mit.edu	37	21	47423435	47423435	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47423435G>T	uc002zhu.1	+	35	2697	c.2595G>T	c.(2593-2595)ACG>ACT	p.T865T	COL6A1_uc010gqd.1_Silent_p.T196T|COL6A1_uc002zhv.1_Silent_p.T196T|COL6A1_uc002zhw.1_5'UTR	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	865	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CGGGCAGGACGGACCCCGCCC	0.701													4	20	---	---	---	---	PASS
MCM3AP	8888	broad.mit.edu	37	21	47699911	47699911	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47699911T>C	uc002zir.1	-	4	1699	c.1663A>G	c.(1663-1665)AAA>GAA	p.K555E		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	555					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					TCCCACCTTTTATTCAGGAGG	0.572													8	76	---	---	---	---	PASS
MICAL3	57553	broad.mit.edu	37	22	18301868	18301868	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18301868C>A	uc002zng.3	-	26	3912	c.3559G>T	c.(3559-3561)GCC>TCC	p.A1187S	MICAL3_uc011agl.1_Missense_Mutation_p.A1103S	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1187	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		TCCTGGGTGGCGGCAGGGACA	0.602													7	15	---	---	---	---	PASS
DGCR8	54487	broad.mit.edu	37	22	20080404	20080404	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20080404G>T	uc002zri.2	+	8	2029	c.1679G>T	c.(1678-1680)AGC>ATC	p.S560I	DGCR8_uc010grz.2_Intron|DGCR8_uc002zrj.2_Missense_Mutation_p.S203I	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	560	Necessary for interaction with DROSHA.|Necessary for heme-binding and pri-miRNA processing.|DRBM 1.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					ACTGCAAGCAGCAAAAAACTT	0.463													61	126	---	---	---	---	PASS
LOC96610	96610	broad.mit.edu	37	22	22749622	22749622	+	RNA	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22749622C>T	uc011aim.1	+	49		c.5619C>T								Parts of antibodies, mostly variable regions.												0						GGAGCAGTCACCAGTGGTTAC	0.552													27	103	---	---	---	---	PASS
MYO18B	84700	broad.mit.edu	37	22	26164471	26164471	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26164471T>C	uc003abz.1	+	4	838	c.588T>C	c.(586-588)TCT>TCC	p.S196S	MYO18B_uc003aca.1_Silent_p.S77S|MYO18B_uc010guy.1_Silent_p.S77S|MYO18B_uc010guz.1_Silent_p.S77S|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	196						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGGAGACCTCTAGGACTCCTT	0.607													11	39	---	---	---	---	PASS
NEFH	4744	broad.mit.edu	37	22	29885966	29885966	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29885966C>A	uc003afo.2	+	4	2408	c.2337C>A	c.(2335-2337)GAC>GAA	p.D779E	NEFH_uc003afp.2_5'UTR	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	785	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament					0						CCCCTGCAGACAAATTCCCTG	0.562													100	76	---	---	---	---	PASS
MYH9	4627	broad.mit.edu	37	22	36684416	36684416	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36684416C>A	uc003apg.2	-	34	5045	c.4814G>T	c.(4813-4815)CGC>CTC	p.R1605L		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1605	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGCCATCGAGCGCTGCTTCCT	0.617			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				28	115	---	---	---	---	PASS
SREBF2	6721	broad.mit.edu	37	22	42300914	42300914	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42300914C>T	uc003bbi.2	+	18	3310	c.3141C>T	c.(3139-3141)CCC>CCT	p.P1047P	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA|SREBF2_uc003bbk.2_5'Flank	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	1047	Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						GAGCCAGCCCCACCCGCACCC	0.677													3	12	---	---	---	---	PASS
ALG12	79087	broad.mit.edu	37	22	50307063	50307063	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50307063C>A	uc003biy.2	-	3	539	c.265G>T	c.(265-267)GAA>TAA	p.E89*		NM_024105	NP_077010	Q9BV10	ALG12_HUMAN	alpha-1,6-mannosyltransferase ALG12	89					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane					0		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		TTGGACATTTCTAACAGCGAA	0.567													4	121	---	---	---	---	PASS
LMF2	91289	broad.mit.edu	37	22	50943701	50943701	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50943701C>T	uc003blp.2	-	8	1145	c.1114G>A	c.(1114-1116)GGT>AGT	p.G372S	LMF2_uc010hba.2_Missense_Mutation_p.G194S|LMF2_uc003blo.2_Missense_Mutation_p.G347S|NCAPH2_uc003blq.3_5'Flank|NCAPH2_uc003blv.2_5'Flank|NCAPH2_uc003blr.3_5'Flank|NCAPH2_uc010hbb.2_5'Flank|NCAPH2_uc003blu.3_5'Flank|NCAPH2_uc003bls.3_5'Flank|NCAPH2_uc003blt.3_5'Flank|NCAPH2_uc003blw.3_5'Flank|NCAPH2_uc003blx.3_5'Flank|NCAPH2_uc003bly.3_5'Flank	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	372	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAGGCCACACCCAGCCACACA	0.652													5	89	---	---	---	---	PASS
STS	412	broad.mit.edu	37	X	7223186	7223186	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:7223186A>G	uc004cry.3	+	7	1303	c.1058A>G	c.(1057-1059)AAA>AGA	p.K353R		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	353	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	GTGTCTTCCAAAGGAGAAATT	0.473									Ichthyosis				39	104	---	---	---	---	PASS
TLR8	51311	broad.mit.edu	37	X	12938413	12938413	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:12938413C>T	uc004cve.2	+	2	1322	c.1254C>T	c.(1252-1254)TCC>TCT	p.S418S	TLR8_uc004cvd.2_Silent_p.S436S	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	418	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						AAAATTTCTCCAATCTGGAAA	0.353													46	147	---	---	---	---	PASS
ASB11	140456	broad.mit.edu	37	X	15333585	15333585	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15333585G>A	uc004cwp.1	-	1	143	c.143C>T	c.(142-144)GCG>GTG	p.A48V	ASB11_uc004cwo.1_5'Flank|ASB11_uc010nes.1_RNA|ASB11_uc010net.1_Missense_Mutation_p.A48V	NM_080873	NP_543149	Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box-containing protein	48					intracellular signal transduction					breast(2)|skin(1)	3	Hepatocellular(33;0.183)					TATCCTAGCCGCTTCTTTTCT	0.308													11	170	---	---	---	---	PASS
BEND2	139105	broad.mit.edu	37	X	18183311	18183311	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18183311G>T	uc004cyj.3	-	14	2372	c.2218C>A	c.(2218-2220)CTC>ATC	p.L740I		NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	740	BEN 2.									ovary(3)|kidney(1)|central_nervous_system(1)	5						TTTTCCGAGAGATCACAAATT	0.443													65	223	---	---	---	---	PASS
SCML2	10389	broad.mit.edu	37	X	18264872	18264872	+	Silent	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18264872T>A	uc004cyl.2	-	13	1804	c.1647A>T	c.(1645-1647)CTA>CTT	p.L549L	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Silent_p.L549L|SCML2_uc011miz.1_Silent_p.L483L|SCML2_uc010nfc.2_Silent_p.L285L	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	549					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					TTCCTGAATTTAGTGATGAGC	0.418													52	182	---	---	---	---	PASS
PTCHD1	139411	broad.mit.edu	37	X	23398156	23398156	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23398156T>A	uc004dal.3	+	2	808	c.800T>A	c.(799-801)GTA>GAA	p.V267E	PTCHD1_uc010nfu.1_Missense_Mutation_p.V267E	NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	267					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						ACCAGCCGCGTATCAGAACGT	0.522													38	141	---	---	---	---	PASS
PCYT1B	9468	broad.mit.edu	37	X	24625900	24625900	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24625900G>A	uc004dbi.2	-	3	529	c.296C>T	c.(295-297)GCA>GTA	p.A99V	PCYT1B_uc004dbk.3_Missense_Mutation_p.A99V|PCYT1B_uc004dbj.2_Missense_Mutation_p.A81V	NM_004845	NP_004836	Q9Y5K3	PCY1B_HUMAN	choline phosphate cytidylyltransferase 1 beta	99	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity				0					Choline(DB00122)	CAGTGTTTTTGCTTGCATAAG	0.423													14	33	---	---	---	---	PASS
TAB3	257397	broad.mit.edu	37	X	30872797	30872797	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30872797G>T	uc004dcj.2	-	6	1648	c.985C>A	c.(985-987)CCA>ACA	p.P329T	TAB3_uc004dck.2_Missense_Mutation_p.P329T|TAB3_uc010ngl.2_Missense_Mutation_p.P329T	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	329	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						GGATGGGGTGGAGTAGTTGAA	0.478													15	85	---	---	---	---	PASS
DMD	1756	broad.mit.edu	37	X	31525435	31525435	+	Nonsense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:31525435T>A	uc004dda.1	-	56	8597	c.8353A>T	c.(8353-8355)AAG>TAG	p.K2785*	DMD_uc004dcq.1_Nonsense_Mutation_p.K56*|DMD_uc004dcr.1_Nonsense_Mutation_p.K325*|DMD_uc004dcs.1_Nonsense_Mutation_p.K325*|DMD_uc004dct.1_Nonsense_Mutation_p.K325*|DMD_uc004dcu.1_Nonsense_Mutation_p.K325*|DMD_uc004dcv.1_Nonsense_Mutation_p.K325*|DMD_uc004dcw.2_Nonsense_Mutation_p.K1441*|DMD_uc004dcx.2_Nonsense_Mutation_p.K1444*|DMD_uc004dcz.2_Nonsense_Mutation_p.K2662*|DMD_uc004dcy.1_Nonsense_Mutation_p.K2781*|DMD_uc004ddb.1_Nonsense_Mutation_p.K2777*	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2785	Spectrin 19.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCACTCCACTTGAAGTTCATG	0.398													44	106	---	---	---	---	PASS
PRRG1	5638	broad.mit.edu	37	X	37312654	37312654	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:37312654C>G	uc004ddn.2	+	5	690	c.437C>G	c.(436-438)CCA>CGA	p.P146R	PRRG1_uc004ddo.2_Missense_Mutation_p.P146R	NM_000950	NP_000941	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	146	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	calcium ion binding			ovary(1)|breast(1)	2						GGATTGTCTCCAGGCTTTCTG	0.532													28	130	---	---	---	---	PASS
SLC9A7	84679	broad.mit.edu	37	X	46510819	46510819	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:46510819A>G	uc004dgu.1	-	9	1173	c.1165T>C	c.(1165-1167)TGT>CGT	p.C389R		NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	389	Helical; (Potential).				regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						GTGATTCCACAGAAAAGGACA	0.423													15	171	---	---	---	---	PASS
PHF16	9767	broad.mit.edu	37	X	46917713	46917713	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:46917713G>T	uc004dgx.2	+	11	1757	c.1706G>T	c.(1705-1707)AGC>ATC	p.S569I	PHF16_uc004dgy.2_Missense_Mutation_p.S569I	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	569					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						TCTCCTGACAGCAGCTCATCT	0.463													11	64	---	---	---	---	PASS
USP11	8237	broad.mit.edu	37	X	47100995	47100995	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47100995A>T	uc004dhp.2	+	9	1205	c.1205A>T	c.(1204-1206)CAG>CTG	p.Q402L	USP11_uc004dhq.2_Missense_Mutation_p.Q129L	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	402					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CATGACTCTCAGGAGCTGCTG	0.537													7	102	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	X	47658073	47658073	+	IGR	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47658073G>T								LOC100133957 (138297 upstream) : ZNF81 (38228 downstream)																							CAGGTCTCTGGATAAGCTGCT	0.473													5	54	---	---	---	---	PASS
PLP2	5355	broad.mit.edu	37	X	49029582	49029582	+	Missense_Mutation	SNP	T	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49029582T>G	uc004dmx.2	+	2	278	c.203T>G	c.(202-204)ATG>AGG	p.M68R		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	68	Helical; (Potential).|MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0						GTTGTCTACATGTGTGACCTG	0.522													6	60	---	---	---	---	PASS
CACNA1F	778	broad.mit.edu	37	X	49077545	49077545	+	Intron	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49077545C>G	uc004dnb.2	-						CACNA1F_uc010nip.2_Intron	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	TCTCCCTGTGCGAGGAAATAG	0.483													3	50	---	---	---	---	PASS
CLCN5	1184	broad.mit.edu	37	X	49851292	49851292	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49851292C>A	uc004dos.1	+	8	1360	c.1112C>A	c.(1111-1113)GCT>GAT	p.A371D	CLCN5_uc004dor.1_Missense_Mutation_p.A441D|CLCN5_uc004doq.1_Missense_Mutation_p.A441D|CLCN5_uc004dot.1_Missense_Mutation_p.A371D	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	371	Helical; (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					GCCATCCTGGCTTTCCCCAAT	0.502													4	77	---	---	---	---	PASS
CCNB3	85417	broad.mit.edu	37	X	50089751	50089751	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:50089751T>A	uc004dox.3	+	10	4053	c.3755T>A	c.(3754-3756)CTC>CAC	p.L1252H	CCNB3_uc004doy.2_Missense_Mutation_p.L1252H|CCNB3_uc004doz.2_Missense_Mutation_p.L148H|CCNB3_uc010njq.2_Missense_Mutation_p.L144H|CCNB3_uc004dpa.2_Missense_Mutation_p.L91H	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1252					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CTGAACGTCCTCAAATGTGAC	0.443													8	59	---	---	---	---	PASS
GSPT2	23708	broad.mit.edu	37	X	51487832	51487832	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:51487832G>T	uc004dpl.2	+	1	1336	c.1110G>T	c.(1108-1110)CTG>CTT	p.L370L		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	370					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					AAGAAAAACTGGTGCCCTTTT	0.383													20	43	---	---	---	---	PASS
SPANXN5	494197	broad.mit.edu	37	X	52825621	52825621	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:52825621C>A	uc004drc.1	-	2	126	c.126G>T	c.(124-126)AAG>AAT	p.K42N		NM_001009616	NP_001009616	Q5MJ07	SPXN5_HUMAN	SPANX family, member N5	42											0	Ovarian(276;0.236)					ATGTTTTCATCTTTTTCAAAC	0.393													29	118	---	---	---	---	PASS
XAGE3	170626	broad.mit.edu	37	X	52895512	52895512	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:52895512G>A	uc004dre.2	-	3	197	c.137C>T	c.(136-138)CCT>CTT	p.P46L	XAGE3_uc004drf.2_Missense_Mutation_p.P46L	NM_130776	NP_570132	Q8WTP9	GAGD4_HUMAN	XAGE-3 protein	46											0						ACCAGGTGCAGGATCCCGACT	0.483													31	95	---	---	---	---	PASS
GPR173	54328	broad.mit.edu	37	X	53105956	53105956	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53105956T>C	uc004dru.2	+	2	411	c.153T>C	c.(151-153)CGT>CGC	p.R51R		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	51	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						TCAAGGAGCGTGCCCTGCACA	0.597													8	48	---	---	---	---	PASS
APEX2	27301	broad.mit.edu	37	X	55028746	55028746	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:55028746C>A	uc004dtz.2	+	3	380	c.304C>A	c.(304-306)CTG>ATG	p.L102M	APEX2_uc011mom.1_Intron	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	102					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						CCTGAGTGGCCTGTTTGCCAC	0.562								Other_BER_factors					14	50	---	---	---	---	PASS
ZC4H2	55906	broad.mit.edu	37	X	64137744	64137744	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64137744C>A	uc004dvu.2	-	5	682	c.594G>T	c.(592-594)CGG>CGT	p.R198R	ZC4H2_uc004dvv.2_Silent_p.R175R|ZC4H2_uc011mov.1_Silent_p.R175R|ZC4H2_uc011mow.1_Missense_Mutation_p.G144V|ZC4H2_uc004dvw.1_3'UTR	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	198	C4H2-type.						metal ion binding|protein binding			ovary(1)	1						TAGGTGCATTCCGGTGAATTT	0.483													20	38	---	---	---	---	PASS
LAS1L	81887	broad.mit.edu	37	X	64738216	64738216	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64738216C>A	uc004dwa.1	-	12	1650	c.1578G>T	c.(1576-1578)GGG>GGT	p.G526G	LAS1L_uc004dwc.1_Silent_p.G509G|LAS1L_uc004dwd.1_Silent_p.G467G|LAS1L_uc004dvy.1_Silent_p.G39G|LAS1L_uc004dvz.1_Silent_p.G39G	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	526						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						ATGGAGACTTCCCAATGGGGG	0.572													30	124	---	---	---	---	PASS
VSIG4	11326	broad.mit.edu	37	X	65253682	65253682	+	Intron	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:65253682C>G	uc004dwh.2	-						VSIG4_uc004dwi.2_Intron|VSIG4_uc010nkq.1_Intron|VSIG4_uc004dwj.2_Intron|VSIG4_uc011moy.1_Intron|VSIG4_uc004dwk.2_Intron|VSIG4_uc004dwl.2_5'Flank	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4						complement activation, alternative pathway	integral to membrane	protein binding				0						CCTGAAGAGGCGGAACAGAGG	0.498													11	83	---	---	---	---	PASS
VSIG4	11326	broad.mit.edu	37	X	65259847	65259847	+	5'UTR	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:65259847C>T	uc004dwh.2	-	1					VSIG4_uc004dwi.2_5'UTR|VSIG4_uc010nkq.1_5'UTR|VSIG4_uc004dwj.2_5'UTR|VSIG4_uc011moy.1_5'UTR|VSIG4_uc004dwk.2_5'UTR	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4						complement activation, alternative pathway	integral to membrane	protein binding				0						CCATCACAGCCAGAGCTACTT	0.562													28	75	---	---	---	---	PASS
HEPH	9843	broad.mit.edu	37	X	65412096	65412096	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:65412096G>T	uc011moz.1	+	7	1257	c.1197G>T	c.(1195-1197)ATG>ATT	p.M399I	HEPH_uc004dwn.2_Missense_Mutation_p.M399I|HEPH_uc004dwo.2_Missense_Mutation_p.M129I|HEPH_uc010nkr.2_Missense_Mutation_p.M399I|HEPH_uc011mpa.1_Missense_Mutation_p.M399I	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	396	Extracellular (Potential).|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						ATGGCCCGATGGGGCATGATG	0.507													21	86	---	---	---	---	PASS
RAB41	347517	broad.mit.edu	37	X	69502122	69502122	+	Missense_Mutation	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69502122G>A	uc004dyc.2	+	1	55	c.55G>A	c.(55-57)GAG>AAG	p.E19K	RAB41_uc010nkv.2_Missense_Mutation_p.E9K	NM_001032726	NP_001027898	Q5JT25	RAB41_HUMAN	RAB41, member RAS oncogene family	19					protein transport|small GTPase mediated signal transduction		GTP binding			ovary(2)|breast(2)	4						CTTTGGTCTGGAGGCTGCCGA	0.562													35	68	---	---	---	---	PASS
TEX11	56159	broad.mit.edu	37	X	69942543	69942543	+	Missense_Mutation	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69942543A>T	uc004dyl.2	-	14	1136	c.974T>A	c.(973-975)GTC>GAC	p.V325D	TEX11_uc004dyk.2_5'UTR|TEX11_uc004dym.2_Missense_Mutation_p.V310D	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	325							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					TATTTCCATGACAGCTAACAA	0.308													11	57	---	---	---	---	PASS
CXorf65	158830	broad.mit.edu	37	X	70323874	70323874	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70323874C>A	uc011mpo.1	-	6	529	c.515G>T	c.(514-516)GGT>GTT	p.G172V	CXorf65_uc011mpp.1_Missense_Mutation_p.G124V	NM_001025265	NP_001020436	A6NEN9	CX065_HUMAN	hypothetical protein LOC158830	172										central_nervous_system(1)	1						GAGTTGGCGACCTTTATTCTT	0.398													20	98	---	---	---	---	PASS
NONO	4841	broad.mit.edu	37	X	70511814	70511814	+	Missense_Mutation	SNP	A	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70511814A>C	uc004dzo.2	+	5	1050	c.340A>C	c.(340-342)ATC>CTC	p.I114L	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Missense_Mutation_p.I114L|NONO_uc004dzp.2_Missense_Mutation_p.I114L|NONO_uc011mpv.1_Missense_Mutation_p.I25L|NONO_uc004dzq.2_5'Flank	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	114	DBHS.|RRM 1.				DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					ATTTGGCTTTATCCGCTTGGT	0.418			T	TFE3	papillary renal cancer								29	139	---	---	---	---	PASS
TAF1	6872	broad.mit.edu	37	X	70597477	70597477	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70597477G>T	uc004dzu.3	+	6	787	c.736G>T	c.(736-738)GGA>TGA	p.G246*	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Nonsense_Mutation_p.G267*	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	246	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				ACGTCTTTTTGGACCAGGGAA	0.473													12	67	---	---	---	---	PASS
ACRC	93953	broad.mit.edu	37	X	70830664	70830664	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70830664C>A	uc004eae.2	+	11	2246	c.1745C>A	c.(1744-1746)TCT>TAT	p.S582Y	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	582						nucleus				ovary(3)	3	Renal(35;0.156)					GTCTGCGACTCTGCAGGTGAT	0.522													3	43	---	---	---	---	PASS
ERCC6L	54821	broad.mit.edu	37	X	71426086	71426086	+	Missense_Mutation	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71426086T>C	uc004eaq.1	-	2	2628	c.2531A>G	c.(2530-2532)CAA>CGA	p.Q844R	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.Q721R	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	844					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					TGTCTCTTTTTGTACAGCTTC	0.373													47	74	---	---	---	---	PASS
ATRX	546	broad.mit.edu	37	X	76919046	76919046	+	Silent	SNP	T	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76919046T>C	uc004ecp.3	-	12	4177	c.3945A>G	c.(3943-3945)GAA>GAG	p.E1315E	ATRX_uc004ecq.3_Silent_p.E1277E|ATRX_uc004eco.3_Silent_p.E1100E|ATRX_uc004ecr.2_Silent_p.E1247E	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1315					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GATTTTTTGCTTCTAAATGAA	0.338			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						12	38	---	---	---	---	PASS
PGAM4	441531	broad.mit.edu	37	X	77224359	77224359	+	3'UTR	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77224359C>G	uc004ecy.1	-	1					ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4						glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						ACAGTATCCTCCCCGCTGGCC	0.577													17	55	---	---	---	---	PASS
BRWD3	254065	broad.mit.edu	37	X	79974986	79974986	+	Splice_Site	SNP	A	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:79974986A>T	uc004edt.2	-	18	2307	c.2044_splice	c.e18+1	p.A682_splice	BRWD3_uc010nmi.1_Intron|BRWD3_uc004edo.2_Splice_Site_p.A278_splice|BRWD3_uc004edp.2_Splice_Site_p.A511_splice|BRWD3_uc004edq.2_Splice_Site_p.A278_splice|BRWD3_uc010nmj.1_Splice_Site_p.A278_splice|BRWD3_uc004edr.2_Splice_Site_p.A352_splice|BRWD3_uc004eds.2_Splice_Site_p.A278_splice|BRWD3_uc004edu.2_Splice_Site_p.A352_splice|BRWD3_uc004edv.2_Splice_Site_p.A278_splice|BRWD3_uc004edw.2_Splice_Site_p.A278_splice|BRWD3_uc004edx.2_Splice_Site_p.A278_splice|BRWD3_uc004edy.2_Splice_Site_p.A278_splice|BRWD3_uc004edz.2_Splice_Site_p.A352_splice|BRWD3_uc004eea.2_Splice_Site_p.A352_splice|BRWD3_uc004eeb.2_Splice_Site_p.A278_splice	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3											ovary(4)	4						AAAAATACTTACCACCATTAA	0.294													18	76	---	---	---	---	PASS
ZNF711	7552	broad.mit.edu	37	X	84510642	84510642	+	Missense_Mutation	SNP	G	A	A	rs3747423		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:84510642G>A	uc004eeo.2	+	4	804	c.457G>A	c.(457-459)GAC>AAC	p.D153N	ZNF711_uc004eep.2_Missense_Mutation_p.D153N|ZNF711_uc004eeq.2_Missense_Mutation_p.D153N	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	153					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						TTCAGGAGTCGACTCTCCCAC	0.448													15	100	---	---	---	---	PASS
CHM	1121	broad.mit.edu	37	X	85156112	85156112	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:85156112G>T	uc004eet.2	-	10	1356	c.1326C>A	c.(1324-1326)AAC>AAA	p.N442K	CHM_uc011mqz.1_Missense_Mutation_p.N294K	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	442					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				GTGAGCACATGTTCTCAGGAA	0.398													11	52	---	---	---	---	PASS
CHM	1121	broad.mit.edu	37	X	85302529	85302529	+	Missense_Mutation	SNP	T	G	G	rs149255670		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:85302529T>G	uc004eet.2	-	1	38	c.8A>C	c.(7-9)GAT>GCT	p.D3A	CHM_uc011mqz.1_5'UTR|CHM_uc004eeu.3_5'Flank|CHM_uc004eev.3_Missense_Mutation_p.D3A	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	3					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				AGGGAGAGTATCCGCCATCTT	0.458													7	23	---	---	---	---	PASS
DACH2	117154	broad.mit.edu	37	X	85906066	85906066	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:85906066C>A	uc004eew.2	+	4	838	c.668C>A	c.(667-669)GCG>GAG	p.A223E	DACH2_uc004eex.2_Missense_Mutation_p.A210E|DACH2_uc010nmq.2_Missense_Mutation_p.A89E|DACH2_uc011mra.1_Missense_Mutation_p.A56E|DACH2_uc010nmr.2_Missense_Mutation_p.A4E	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						ATGGCTGAGGCGATGAAACTT	0.323													14	26	---	---	---	---	PASS
KLHL4	56062	broad.mit.edu	37	X	86888805	86888805	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:86888805T>A	uc004efb.2	+	8	1788	c.1606T>A	c.(1606-1608)TAT>AAT	p.Y536N	KLHL4_uc004efa.2_Missense_Mutation_p.Y536N	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	536	Kelch 3.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TGGATGGAGCTATCTAAATAC	0.423													36	63	---	---	---	---	PASS
TGIF2LX	90316	broad.mit.edu	37	X	89177752	89177752	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:89177752C>A	uc004efe.2	+	2	717	c.668C>A	c.(667-669)GCA>GAA	p.A223E		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	223						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CTAGTCGATGCAGCAGTACAA	0.493													32	48	---	---	---	---	PASS
PABPC5	140886	broad.mit.edu	37	X	90690693	90690693	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:90690693G>T	uc004efg.2	+	2	557	c.117G>T	c.(115-117)AGG>AGT	p.R39S	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	39	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						AGAAGTTCAGGCCTGCTGGCC	0.562													6	33	---	---	---	---	PASS
PCDH11X	27328	broad.mit.edu	37	X	91090873	91090873	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:91090873A>G	uc004efk.1	+	1	1215	c.370A>G	c.(370-372)AAG>GAG	p.K124E	PCDH11X_uc004efl.1_Missense_Mutation_p.K124E|PCDH11X_uc004efo.1_Missense_Mutation_p.K124E|PCDH11X_uc010nmv.1_Missense_Mutation_p.K124E|PCDH11X_uc004efm.1_Missense_Mutation_p.K124E|PCDH11X_uc004efn.1_Missense_Mutation_p.K124E|PCDH11X_uc004efh.1_Missense_Mutation_p.K124E|PCDH11X_uc004efj.1_Missense_Mutation_p.K124E	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	124	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TAGACTGGTTAAGATACGTTT	0.373													24	81	---	---	---	---	PASS
PCDH11X	27328	broad.mit.edu	37	X	91873434	91873434	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:91873434C>A	uc004efk.1	+	7	4384	c.3539C>A	c.(3538-3540)GCC>GAC	p.A1180D	PCDH11X_uc004efl.1_Missense_Mutation_p.A1170D|PCDH11X_uc004efo.1_Missense_Mutation_p.A1143D|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.A1172D|PCDH11X_uc004efn.1_Missense_Mutation_p.A1162D	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1180	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTGTCACAGGCCTCTACTCAG	0.597													59	107	---	---	---	---	PASS
PCDH11X	27328	broad.mit.edu	37	X	91873655	91873655	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:91873655G>C	uc004efk.1	+	7	4605	c.3760G>C	c.(3760-3762)GCA>CCA	p.A1254P	PCDH11X_uc004efl.1_Missense_Mutation_p.A1244P|PCDH11X_uc004efo.1_Missense_Mutation_p.A1217P|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.A1246P|PCDH11X_uc004efn.1_Missense_Mutation_p.A1236P	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1254	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ACAGGCTGCTGCAATCAGCCA	0.572													20	149	---	---	---	---	PASS
TRMT2B	79979	broad.mit.edu	37	X	100273996	100273996	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100273996C>T	uc004egq.2	-	12	1651	c.1352G>A	c.(1351-1353)TGC>TAC	p.C451Y	TRMT2B_uc004egp.2_RNA|TRMT2B_uc004egr.2_Missense_Mutation_p.C451Y|TRMT2B_uc004egs.2_Missense_Mutation_p.C451Y|TRMT2B_uc004egt.2_Missense_Mutation_p.C451Y|TRMT2B_uc004egu.2_Missense_Mutation_p.C332Y|TRMT2B_uc004egv.2_Missense_Mutation_p.C406Y	NM_024917	NP_079193	Q96GJ1	TRM2_HUMAN	TRM2 tRNA methyltransferase 2 homolog B	451		Nucleophile (By similarity).		C -> R (in Ref. 2; CAI46112).			tRNA (uracil-5-)-methyltransferase activity			ovary(1)	1						ATGGAGCTTGCAGGAAACAAA	0.313													54	107	---	---	---	---	PASS
ZMAT1	84460	broad.mit.edu	37	X	101153010	101153010	+	Silent	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:101153010A>G	uc011mrl.1	-	5	647	c.336T>C	c.(334-336)CAT>CAC	p.H112H	ZMAT1_uc004ein.2_5'UTR|ZMAT1_uc011mrm.1_5'UTR	NM_001011657	NP_001011657	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 1	Error:Variant_position_missing_in_A7MD47_after_alignment						nucleus	zinc ion binding			ovary(1)	1						CTTCATACCTATGCACCTGAA	0.383													27	119	---	---	---	---	PASS
MORF4L2	9643	broad.mit.edu	37	X	102931462	102931462	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102931462C>T	uc004ekw.2	-	4	1726	c.494G>A	c.(493-495)TGC>TAC	p.C165Y	MORF4L2_uc004ela.2_Missense_Mutation_p.C165Y|MORF4L2_uc004ekx.2_Missense_Mutation_p.C165Y|MORF4L2_uc004elb.2_Missense_Mutation_p.C165Y|MORF4L2_uc004eky.2_Missense_Mutation_p.C165Y|MORF4L2_uc010nos.2_Missense_Mutation_p.C165Y|MORF4L2_uc004ekz.2_Missense_Mutation_p.C165Y|MORF4L2_uc011mry.1_Missense_Mutation_p.C165Y|MORF4L2_uc011mrz.1_Missense_Mutation_p.C165Y|MORF4L2_uc004elc.2_Missense_Mutation_p.C165Y|MORF4L2_uc004elf.2_Missense_Mutation_p.C165Y|MORF4L2_uc004ele.2_Missense_Mutation_p.C165Y|MORF4L2_uc011msa.1_Missense_Mutation_p.C165Y|MORF4L2_uc011msb.1_Missense_Mutation_p.C165Y|MORF4L2_uc011msc.1_Missense_Mutation_p.C165Y|MORF4L2_uc011msd.1_Missense_Mutation_p.C165Y|MORF4L2_uc004eld.2_Missense_Mutation_p.C165Y	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	165					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						CGATTTCTTGCAATTTGCATA	0.418													103	163	---	---	---	---	PASS
GLRA4	441509	broad.mit.edu	37	X	102962291	102962291	+	Missense_Mutation	SNP	C	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102962291C>G	uc011mse.1	-	9	1656	c.1235G>C	c.(1234-1236)CGG>CCG	p.R412P		NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	412	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						GTAGAGTTTCCGCGTGGTTTC	0.512													18	93	---	---	---	---	PASS
GLRA4	441509	broad.mit.edu	37	X	102962376	102962376	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102962376C>T	uc011mse.1	-	9	1571	c.1150G>A	c.(1150-1152)GCA>ACA	p.A384T		NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	384	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						CCATCTCTTGCCTGCAGGCAG	0.498													17	67	---	---	---	---	PASS
H2BFWT	158983	broad.mit.edu	37	X	103267933	103267933	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:103267933C>A	uc004elr.2	-	1	324	c.300G>T	c.(298-300)CGG>CGT	p.R100R		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	100					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						TCACGGCCTCCCGGGAAAGGC	0.637													6	59	---	---	---	---	PASS
TEX13A	56157	broad.mit.edu	37	X	104464885	104464885	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:104464885G>T	uc004ema.2	-	2	309	c.197C>A	c.(196-198)GCC>GAC	p.A66D	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.A66D	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	66						intracellular	zinc ion binding			ovary(2)	2						CCAGGTGCAGGCCTCTTTGAC	0.587													22	37	---	---	---	---	PASS
NRK	203447	broad.mit.edu	37	X	105153578	105153578	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:105153578C>A	uc004emd.2	+	13	2248	c.1945C>A	c.(1945-1947)CGG>AGG	p.R649R	NRK_uc010npc.1_Silent_p.R317R	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	649							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						AGACTTGCTTCGGGCACCAAA	0.478										HNSCC(51;0.14)			7	27	---	---	---	---	PASS
NUP62CL	54830	broad.mit.edu	37	X	106411002	106411002	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106411002G>T	uc004ena.2	-	4	330	c.71C>A	c.(70-72)ACG>AAG	p.T24K	NUP62CL_uc004enb.2_RNA	NM_017681	NP_060151	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	24	Thr-rich.				protein transport	nuclear pore	structural constituent of nuclear pore				0						ggtggtagtcgtTGAAGTTGT	0.239													26	156	---	---	---	---	PASS
TSC22D3	1831	broad.mit.edu	37	X	107018452	107018452	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107018452G>T	uc004enh.2	-	1	566	c.198C>A	c.(196-198)AAC>AAA	p.N66K	TSC22D3_uc004eni.2_Missense_Mutation_p.N66K|TSC22D3_uc004enj.2_Missense_Mutation_p.N66K	NM_198057	NP_932174	Q99576	T22D3_HUMAN	TSC22 domain family, member 3 isoform 1	Error:Variant_position_missing_in_Q99576_after_alignment							sequence-specific DNA binding transcription factor activity				0						GCATTATGCTGTTGAGCTTGT	0.572													16	111	---	---	---	---	PASS
IRS4	8471	broad.mit.edu	37	X	107975873	107975873	+	Silent	SNP	G	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107975873G>A	uc004eoc.2	-	1	3735	c.3702C>T	c.(3700-3702)GAC>GAT	p.D1234D		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	1234						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GAGTGTCGTCGTCGTTGTCAG	0.542													8	296	---	---	---	---	PASS
RGAG1	57529	broad.mit.edu	37	X	109697270	109697270	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:109697270G>T	uc004eor.1	+	3	3671	c.3425G>T	c.(3424-3426)GGA>GTA	p.G1142V	RGAG1_uc011msr.1_Missense_Mutation_p.G1142V	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1142										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CCATCCTTCGGAATGTTGACC	0.522													32	169	---	---	---	---	PASS
TRPC5	7224	broad.mit.edu	37	X	111195429	111195429	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:111195429G>C	uc004epl.1	-	2	1139	c.220C>G	c.(220-222)CTG>GTG	p.L74V	TRPC5_uc004epm.1_Missense_Mutation_p.L74V	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	74	ANK 2.|Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						GCAATGAGCAGGGCACTCCGG	0.527													22	160	---	---	---	---	PASS
ZCCHC16	340595	broad.mit.edu	37	X	111698772	111698772	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:111698772C>A	uc004epo.1	+	3	1257	c.816C>A	c.(814-816)GCC>GCA	p.A272A		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	272							nucleic acid binding|zinc ion binding			ovary(1)	1						CCAAACGAGCCCGCCAGCAAG	0.552													41	25	---	---	---	---	PASS
LRCH2	57631	broad.mit.edu	37	X	114357364	114357364	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114357364G>T	uc010nqe.2	-	19	2090	c.2059C>A	c.(2059-2061)CCA>ACA	p.P687T	LRCH2_uc004epz.2_Missense_Mutation_p.P670T	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	687	CH.									ovary(1)	1						ACAGAACGTGGCCTTATATGA	0.368													7	49	---	---	---	---	PASS
KIAA1210	57481	broad.mit.edu	37	X	118242299	118242299	+	Splice_Site	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118242299C>A	uc004era.3	-	6	912	c.912_splice	c.e6+1	p.E304_splice		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481											ovary(4)|skin(1)	5						cactTTGTTACCTCAGTGATC	0.274													76	149	---	---	---	---	PASS
LAMP2	3920	broad.mit.edu	37	X	119575625	119575625	+	Silent	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119575625C>T	uc004est.3	-	8	1233	c.1053G>A	c.(1051-1053)AGG>AGA	p.R351R	LAMP2_uc004ess.3_Silent_p.R351R|LAMP2_uc011mtz.1_Silent_p.R240R|LAMP2_uc011mua.1_Silent_p.R304R|LAMP2_uc010nqp.1_Silent_p.R351R	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	351	Lumenal (Potential).|Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						AAGGCTGAACCCTTAGATCAA	0.398													21	147	---	---	---	---	PASS
OCRL	4952	broad.mit.edu	37	X	128692840	128692840	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:128692840C>A	uc004euq.2	+	8	749	c.584C>A	c.(583-585)TCT>TAT	p.S195Y	OCRL_uc004eur.2_Missense_Mutation_p.S195Y	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	195					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						AAAGAAGCTTCTAACAAGGAG	0.408													10	122	---	---	---	---	PASS
XPNPEP2	7512	broad.mit.edu	37	X	128886218	128886218	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:128886218A>G	uc004eut.1	+	10	1158	c.914A>G	c.(913-915)TAC>TGC	p.Y305C		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	305					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						ATCGAGGATTACAGCCAAGTT	0.493													43	122	---	---	---	---	PASS
ELF4	2000	broad.mit.edu	37	X	129201404	129201404	+	Silent	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129201404C>A	uc004evd.3	-	9	1669	c.1284G>T	c.(1282-1284)CTG>CTT	p.L428L	ELF4_uc004eve.3_Silent_p.L428L	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	428					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCCATTGGTCAGCACCGTGG	0.607			T	ERG	AML								7	81	---	---	---	---	PASS
ELF4	2000	broad.mit.edu	37	X	129203533	129203533	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129203533G>C	uc004evd.3	-	8	1314	c.929C>G	c.(928-930)ACA>AGA	p.T310R	ELF4_uc004eve.3_Missense_Mutation_p.T310R	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	310					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGGGCTGCTGTGGCTTCGCT	0.607			T	ERG	AML								11	81	---	---	---	---	PASS
IGSF1	3547	broad.mit.edu	37	X	130409704	130409704	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:130409704T>A	uc004ewd.2	-	16	3170	c.2932A>T	c.(2932-2934)AGT>TGT	p.S978C	IGSF1_uc004ewe.3_Missense_Mutation_p.S972C|IGSF1_uc004ewf.2_Missense_Mutation_p.S958C	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	978	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						ACCACAGAACTGGGCTCAGCA	0.463													20	193	---	---	---	---	PASS
ZNF449	203523	broad.mit.edu	37	X	134483069	134483069	+	Missense_Mutation	SNP	C	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134483069C>T	uc004eys.2	+	3	554	c.389C>T	c.(388-390)GCA>GTA	p.A130V	ZNF449_uc004eyq.1_3'UTR|ZNF449_uc004eyt.2_Missense_Mutation_p.A10V	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	130					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGAACTGGCACCAGTGGGA	0.478													7	269	---	---	---	---	PASS
SAGE1	55511	broad.mit.edu	37	X	134990767	134990767	+	Missense_Mutation	SNP	A	G	G			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134990767A>G	uc004ezh.2	+	12	1599	c.1432A>G	c.(1432-1434)AGG>GGG	p.R478G	SAGE1_uc010nry.1_Missense_Mutation_p.R447G|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	478										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AATGAGTTCCAGGGATCTGTG	0.393													55	123	---	---	---	---	PASS
MAP7D3	79649	broad.mit.edu	37	X	135302935	135302935	+	Missense_Mutation	SNP	T	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135302935T>A	uc004ezt.2	-	16	2566	c.2475A>T	c.(2473-2475)GAA>GAT	p.E825D	MAP7D3_uc004ezs.2_Missense_Mutation_p.E789D|MAP7D3_uc011mwc.1_Missense_Mutation_p.E807D|MAP7D3_uc010nsa.1_Missense_Mutation_p.E783D	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	825						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					TTGAAACTACTTCCTGTATTG	0.328													35	275	---	---	---	---	PASS
MAP7D3	79649	broad.mit.edu	37	X	135309469	135309469	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135309469G>T	uc004ezt.2	-	12	2099	c.2008C>A	c.(2008-2010)CAG>AAG	p.Q670K	MAP7D3_uc004ezs.2_Missense_Mutation_p.Q634K|MAP7D3_uc011mwc.1_Missense_Mutation_p.Q652K|MAP7D3_uc010nsa.1_Missense_Mutation_p.Q628K	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	670						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					TGGTCTTCCTGATCCAGCCAT	0.453													9	100	---	---	---	---	PASS
CXorf66	347487	broad.mit.edu	37	X	139038432	139038432	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:139038432C>A	uc004fbb.2	-	3	731	c.709G>T	c.(709-711)GCT>TCT	p.A237S		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	237	Cytoplasmic (Potential).					integral to membrane					0						GGAGGCTTAGCCAATTCCTGT	0.438													106	144	---	---	---	---	PASS
GPR50	9248	broad.mit.edu	37	X	150348607	150348607	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150348607C>A	uc010ntg.1	+	2	687	c.552C>A	c.(550-552)AAC>AAA	p.N184K	uc004fes.1_5'Flank|GPR50_uc011myc.1_Missense_Mutation_p.N184K	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	184	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					ACTATCTGAACAACCCTGTCT	0.537													19	170	---	---	---	---	PASS
MAGEA4	4103	broad.mit.edu	37	X	151091965	151091965	+	5'UTR	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151091965G>T	uc004fez.2	+	2					MAGEA4_uc004ffa.2_5'UTR|MAGEA4_uc004ffb.2_5'UTR|MAGEA4_uc004ffc.2_5'UTR|MAGEA4_uc004ffd.2_5'UTR	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4								protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGATTCCCTGGAGGCCACAGA	0.542													9	73	---	---	---	---	PASS
GABRE	2564	broad.mit.edu	37	X	151130932	151130932	+	Missense_Mutation	SNP	G	C	C			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151130932G>C	uc004ffi.2	-	4	580	c.526C>G	c.(526-528)CGC>GGC	p.R176G	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA|MIR452_hsa-mir-452|MI0001733_5'Flank	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	176	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTAGATGCGGACCATCTGG	0.478													3	58	---	---	---	---	PASS
MAGEA6	4105	broad.mit.edu	37	X	151870148	151870148	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151870148G>T	uc004ffq.1	+	3	1032	c.838G>T	c.(838-840)GAA>TAA	p.E280*	MAGEA6_uc004ffr.1_Nonsense_Mutation_p.E280*|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	280	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCCTCATTGAAACCAGCTA	0.537													17	235	---	---	---	---	PASS
PNMA5	114824	broad.mit.edu	37	X	152159311	152159311	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152159311G>T	uc010ntw.2	-	3	1171	c.832C>A	c.(832-834)CCC>ACC	p.P278T	PNMA5_uc004fha.3_Missense_Mutation_p.P278T|PNMA5_uc010ntx.2_Missense_Mutation_p.P278T|PNMA5_uc004fgy.3_Missense_Mutation_p.P278T	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	278					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ACTGACAAGGGGCTCTTGTGC	0.557													11	122	---	---	---	---	PASS
PLXNB3	5365	broad.mit.edu	37	X	153040421	153040421	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153040421G>T	uc004fii.2	+	24	4192	c.4018G>T	c.(4018-4020)GCC>TCC	p.A1340S	PLXNB3_uc010nuk.2_Missense_Mutation_p.A1363S|PLXNB3_uc011mzd.1_Missense_Mutation_p.A979S|PLXNB3_uc004fij.1_RNA|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1340	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CGCCGAGCGCGCCTTCTTCCC	0.697													9	57	---	---	---	---	PASS
IRAK1	3654	broad.mit.edu	37	X	153284161	153284161	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153284161G>T	uc004fjs.1	-	5	697	c.618C>A	c.(616-618)TCC>TCA	p.S206S	IRAK1_uc004fjr.1_Silent_p.S206S|IRAK1_uc004fjt.1_Silent_p.S206S|IRAK1_uc010nur.2_Intron|IRAK1_uc004fju.2_Silent_p.S232S	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	206	ProST region.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGTGCCCCGGGAAATCTCAC	0.617													12	83	---	---	---	---	PASS
CTAG2	30848	broad.mit.edu	37	X	153880866	153880866	+	Missense_Mutation	SNP	C	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153880866C>A	uc004fmi.1	-	2	362	c.309G>T	c.(307-309)GAG>GAT	p.E103D	CTAG2_uc004fmh.1_Missense_Mutation_p.E103D	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	103						centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCGGACCAGCTCCGCTTCCA	0.617													8	68	---	---	---	---	PASS
F8	2157	broad.mit.edu	37	X	154157610	154157610	+	Silent	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154157610G>T	uc004fmt.2	-	14	4626	c.4455C>A	c.(4453-4455)GCC>GCA	p.A1485A		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1485	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CTGAATTTGTGGCACTTGTCC	0.418													11	111	---	---	---	---	PASS
FUNDC2	65991	broad.mit.edu	37	X	154261828	154261828	+	Missense_Mutation	SNP	G	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154261828G>T	uc004fmw.2	+	2	434	c.284G>T	c.(283-285)TGG>TTG	p.W95L		NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	95						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTCACTGGATGGTAAGTGATG	0.458													13	116	---	---	---	---	PASS
ZBTB40	9923	broad.mit.edu	37	1	22832398	22832398	+	Intron	DEL	A	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22832398delA	uc001bft.2	+						ZBTB40_uc001bfu.2_Intron|ZBTB40_uc009vqi.1_Intron|ZBTB40_uc001bfv.1_Intron	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40						bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		AGAAACTATGAAAAAAAGTAA	0.338													3	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	1	142803276	142803278	+	Intron	DEL	AAC	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:142803276_142803278delAAC	uc001eiw.1	+						uc001ejb.2_RNA|uc001ejc.2_5'Flank					Homo sapiens PNAS-130 mRNA, complete cds.																		ACCAAACCAAaacaacaacaaca	0.241													5	3	---	---	---	---	
HIST3H2A	92815	broad.mit.edu	37	1	228646357	228646358	+	5'Flank	DEL	GT	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228646357_228646358delGT	uc001hsy.2	-							NM_033445	NP_254280	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a						nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1		Prostate(94;0.183)				AATCTGAGCCgtgtgtgtgtgt	0.475													4	2	---	---	---	---	
PUM2	23369	broad.mit.edu	37	2	20526893	20526893	+	Intron	DEL	T	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20526893delT	uc002rds.1	-						PUM2_uc002rdt.1_Intron|PUM2_uc002rdr.2_Intron|PUM2_uc010yjy.1_Intron|PUM2_uc002rdu.1_Intron|PUM2_uc010yjz.1_Intron	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2						regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTAAAAGCTTTTTTTTTAA	0.299													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	2	34041837	34041838	+	IGR	INS	-	CCTCC	CCTCC	rs141683394	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:34041837_34041838insCCTCC								MYADML (88553 upstream) : None (None downstream)																							tcttctcttctcctcccctccc	0.000													4	4	---	---	---	---	
Unknown	0	broad.mit.edu	37	2	113103992	113103992	+	IGR	DEL	C	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113103992delC								ZC3H6 (6352 upstream) : RGPD8 (21974 downstream)																							tcaccaccatcaccactgcca	0.000													4	4	---	---	---	---	
MAP4	4134	broad.mit.edu	37	3	47910733	47910733	+	Frame_Shift_Del	DEL	C	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47910733delC	uc003csb.2	-	14	3470	c.2944delG	c.(2944-2946)GCAfs	p.A982fs	MAP4_uc003csc.3_Frame_Shift_Del_p.A982fs|MAP4_uc003crw.2_Intron|MAP4_uc003crx.2_Intron|MAP4_uc011bbe.1_Intron|MAP4_uc003cry.2_Frame_Shift_Del_p.A717fs|MAP4_uc003csa.3_Intron|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Frame_Shift_Del_p.A702fs	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	982					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGTGCACTTGCAATTGGGCCG	0.468													78	58	---	---	---	---	
CCDC36	339834	broad.mit.edu	37	3	49278972	49278973	+	Intron	DEL	AC	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49278972_49278973delAC	uc003cwk.2	+						CCDC36_uc003cwl.3_Intron|CCDC36_uc011bck.1_Intron	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36											ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		acacacacatacacacacacac	0.079													4	2	---	---	---	---	
CADM2	253559	broad.mit.edu	37	3	85855318	85855321	+	Intron	DEL	GAGG	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:85855318_85855321delGAGG	uc003dqj.2	+						CADM2_uc003dqk.2_Intron|CADM2_uc003dql.2_Intron	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D						adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		gaaaagaagcgagggagggaggga	0.206													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	3	134124124	134124127	+	IGR	DEL	ACAC	-	-	rs10539117		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:134124124_134124127delACAC								AMOTL2 (29865 upstream) : ANAPC13 (72420 downstream)																							TTacacacaaacacacacacacac	0.309													4	2	---	---	---	---	
HLTF	6596	broad.mit.edu	37	3	148763829	148763830	+	Intron	INS	-	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148763829_148763830insA	uc003ewq.1	-						HLTF_uc003ewr.1_Intron|HLTF_uc003ews.1_Intron|HLTF_uc010hve.1_Intron	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor						chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			ACAAAGTAAACAAAAACTAATT	0.307													67	31	---	---	---	---	
YEATS2	55689	broad.mit.edu	37	3	183440065	183440073	+	Intron	DEL	TCTTTTTTT	-	-	rs151175192		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183440065_183440073delTCTTTTTTT	uc003fly.2	+							NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2						histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ggaaaccaaatcttttttttttttttttt	0.053													9	4	---	---	---	---	
Unknown	0	broad.mit.edu	37	3	191472527	191472528	+	IGR	INS	-	TG	TG	rs137855291	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:191472527_191472528insTG								PYDC2 (293284 upstream) : FGF12 (387156 downstream)																							gtgggtatgtttgtgtgtgtgt	0.168													6	5	---	---	---	---	
ATP13A5	344905	broad.mit.edu	37	3	193033067	193033067	+	Intron	DEL	T	-	-	rs35629445		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193033067delT	uc011bsq.1	-							NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		acctcacccctctccttccta	0.005													8	11	---	---	---	---	
KIAA1530	57654	broad.mit.edu	37	4	1348691	1348692	+	Intron	INS	-	G	G	rs138445940	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1348691_1348692insG	uc003gde.3	+							NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654												0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			GTGCCATGCATGGGGGGGGTCC	0.639													6	3	---	---	---	---	
LIAS	11019	broad.mit.edu	37	4	39478849	39478849	+	3'UTR	DEL	A	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39478849delA	uc003guf.2	+	11					LIAS_uc003gug.2_3'UTR|LIAS_uc003guh.2_3'UTR	NM_006859	NP_006850	O43766	LIAS_HUMAN	lipoic acid synthetase isoform 1 precursor						inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding				0					Lipoic Acid(DB00166)	CTCTTTGCTTAAAAAAAAAAA	0.224													6	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	4	46725774	46725774	+	IGR	DEL	T	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:46725774delT								GABRA2 (333353 upstream) : COX7B2 (11075 downstream)																							tttttcttggttttttttttt	0.343													2	4	---	---	---	---	
GABRB1	2560	broad.mit.edu	37	4	47034145	47034146	+	Intron	INS	-	CA	CA	rs73247629		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:47034145_47034146insCA	uc003gxh.2	+						GABRB1_uc011bze.1_Intron|GABRB1_uc011bzd.1_Intron|GABRB1_uc010igg.2_Intron	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta						synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TATACCCTGGGcacacacacac	0.421													6	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	4	49099485	49099489	+	IGR	DEL	CTCCT	-	-	rs62641946		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:49099485_49099489delCTCCT								CWH43 (35392 upstream) : None (None downstream)																							ttccattccactcctttccattcca	0.000													4	2	---	---	---	---	
ENPEP	2028	broad.mit.edu	37	4	111470422	111470422	+	Intron	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:111470422delG	uc003iab.3	+							NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase						cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GATTATAACAGGGGCTGCTGA	0.303													15	12	---	---	---	---	
NDST4	64579	broad.mit.edu	37	4	115997817	115997818	+	Frame_Shift_Ins	INS	-	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:115997817_115997818insT	uc003ibu.2	-	2	1054_1055	c.375_376insA	c.(373-378)AAAGGGfs	p.K125fs	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	125_126	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GTATATTTCCCTTTGCCATTAT	0.376													64	33	---	---	---	---	
SMARCA5	8467	broad.mit.edu	37	4	144442476	144442477	+	Intron	INS	-	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:144442476_144442477insT	uc003ijg.2	+							NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated						CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)					ctgtagttctcttttttttttt	0.084													9	4	---	---	---	---	
DCLK2	166614	broad.mit.edu	37	4	151120062	151120063	+	Intron	INS	-	C	C	rs71596224		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151120062_151120063insC	uc003ilm.3	+						DCLK2_uc003iln.3_Intron|DCLK2_uc003ilo.3_Intron|DCLK2_uc003ilp.3_Intron	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a						intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					CCCTTTCAGCACCCCCCCCCCC	0.446													4	2	---	---	---	---	
PCDHGB3	56102	broad.mit.edu	37	5	140751962	140751963	+	Frame_Shift_Ins	INS	-	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140751962_140751963insT	uc003ljw.1	+	1	2001_2002	c.2001_2002insT	c.(1999-2004)AGCTTGfs	p.S667fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Frame_Shift_Ins_p.S667fs|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	667_668	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGCAGATAGCTTGCAAGAGAT	0.589													59	34	---	---	---	---	
DDX41	51428	broad.mit.edu	37	5	176942393	176942393	+	Intron	DEL	A	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176942393delA	uc003mho.2	-						DDX41_uc003mhm.2_5'UTR|DDX41_uc003mhn.2_Intron|DDX41_uc003mhp.2_Intron|DDX41_uc003mhq.1_5'UTR	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt						apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			gagagagtggaaaaaaaaaaa	0.070													3	3	---	---	---	---	
FAM65B	9750	broad.mit.edu	37	6	24851127	24851127	+	Intron	DEL	T	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24851127delT	uc003neo.1	-						FAM65B_uc011djs.1_Intron|FAM65B_uc011dju.1_Intron|FAM65B_uc003nep.2_Intron|FAM65B_uc011djt.1_Intron	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1						cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						GGGAGGAGACttttttttttt	0.289													4	4	---	---	---	---	
PRDM13	59336	broad.mit.edu	37	6	100061970	100061970	+	Frame_Shift_Del	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:100061970delG	uc003pqg.1	+	4	1720	c.1459delG	c.(1459-1461)GGCfs	p.G487fs		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		ATTGCACTTCGGCGGGCTGCT	0.657													41	18	---	---	---	---	
C6orf174	387104	broad.mit.edu	37	6	127771626	127771626	+	Intron	DEL	T	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:127771626delT	uc003qbd.2	-						C6orf174_uc003qbc.2_Intron|C6orf174_uc003qbb.2_5'UTR|KIAA0408_uc011ebs.1_Intron	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor							integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		GTATTAATGCTTCGGCCTCCA	0.363													4	2	---	---	---	---	
ARID1B	57492	broad.mit.edu	37	6	157360839	157360839	+	Intron	DEL	C	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:157360839delC	uc003qqn.2	+						ARID1B_uc003qqo.2_Intron|ARID1B_uc003qqp.2_Intron|ARID1B_uc003qqq.1_Intron	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)						chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		ttctttctttcctttctttcc	0.020													4	3	---	---	---	---	
C7orf28B	221960	broad.mit.edu	37	7	6840334	6840334	+	Intron	DEL	T	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6840334delT	uc003sqx.1	-						C7orf28B_uc011jxd.1_Intron	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960							lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)		TATAAAGTCATTTTTTTTTTT	0.204													4	2	---	---	---	---	
PMS2L3	5387	broad.mit.edu	37	7	75145720	75145721	+	Intron	DEL	AT	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:75145720_75145721delAT	uc003udp.2	-						PMS2L3_uc003udn.2_Intron|PMS2L3_uc003udq.2_Intron|PMS2L3_uc003udr.1_Intron	NM_005395	NP_005386			SubName: Full=Postmeiotic segregation increased 2-like 3; SubName: Full=Postmeiotic segregation increased 2-like 3, isoform CRA_b;												0						TCCTTTGGGGatatatatatat	0.193								Direct_reversal_of_damage|MMR					4	2	---	---	---	---	
PMPCB	9512	broad.mit.edu	37	7	102948026	102948027	+	Intron	INS	-	T	T			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102948026_102948027insT	uc003vbl.2	+						PMPCB_uc010liu.1_Intron|PMPCB_uc003vbk.1_Intron|PMPCB_uc003vbm.2_Intron|PMPCB_uc010liv.2_Intron|PMPCB_uc010liw.2_Intron|PMPCB_uc011kll.1_Intron|PMPCB_uc011klm.1_Intron	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit						proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4						ATGTGAAAATATTTTCTTTCAA	0.347													35	16	---	---	---	---	
MSR1	4481	broad.mit.edu	37	8	15967535	15967535	+	3'UTR	DEL	A	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:15967535delA	uc003wwz.2	-	10					MSR1_uc010lsu.2_3'UTR|MSR1_uc003wxa.2_3'UTR	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1						cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TTACAGGAACAAGGTAATAAA	0.289													25	26	---	---	---	---	
Unknown	0	broad.mit.edu	37	8	110948437	110948440	+	IGR	DEL	AGGA	-	-	rs147604132	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110948437_110948440delAGGA								SYBU (244417 upstream) : KCNV1 (30795 downstream)																							ggagggagggaggaaggaaggaag	0.103													5	4	---	---	---	---	
Unknown	0	broad.mit.edu	37	8	112357544	112357547	+	IGR	DEL	GGAA	-	-	rs5894039		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:112357544_112357547delGGAA								None (None upstream) : CSMD3 (877614 downstream)																							gaggaaggacggaaggaaggaagg	0.127													5	4	---	---	---	---	
PVT1	5820	broad.mit.edu	37	8	128901332	128901347	+	Intron	DEL	TCCTTCCTTCCTTCCC	-	-	rs72397993		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:128901332_128901347delTCCTTCCTTCCTTCCC	uc010mdq.2	+						PVT1_uc003ysl.2_5'Flank|PVT1_uc010mdp.1_Intron	NR_003367				Homo sapiens Pvt1 oncogene (non-protein coding), mRNA (cDNA clone IMAGE:5517530), with apparent retained intron.												0						cttccttccttccttccttccttccctccttccttc	0.106													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	9	91131691	91131702	+	IGR	DEL	TCCCTCCCTCCC	-	-	rs11142332		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91131691_91131702delTCCCTCCCTCCC								SPIN1 (38071 upstream) : NXNL2 (18314 downstream)																							cttccttccttccctccctccctccttccttc	0.009													5	3	---	---	---	---	
SVEP1	79987	broad.mit.edu	37	9	113192403	113192404	+	Intron	INS	-	GT	GT	rs35386381	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:113192403_113192404insGT	uc010mtz.2	-						SVEP1_uc010mty.2_5'Flank	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom						cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ttttttttttGGTGTGTGTGTG	0.322													6	3	---	---	---	---	
CDK5RAP2	55755	broad.mit.edu	37	9	123230282	123230282	+	Intron	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123230282delG	uc004bkf.2	-						CDK5RAP2_uc004bke.2_Intron|CDK5RAP2_uc004bkg.2_Intron|CDK5RAP2_uc011lxw.1_Intron|CDK5RAP2_uc011lxx.1_Intron|CDK5RAP2_uc011lxy.1_Intron|CDK5RAP2_uc011lxz.1_Intron|CDK5RAP2_uc011lya.1_Intron|CDK5RAP2_uc004bkh.1_Intron|CDK5RAP2_uc004bki.2_Intron	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2						brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						TGACCTAGGAGGTAAGAACAG	0.512													70	41	---	---	---	---	
Unknown	0	broad.mit.edu	37	10	42392302	42392302	+	IGR	DEL	G	-	-	rs72505279		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:42392302delG								None (None upstream) : LOC441666 (435013 downstream)																							aacatcgaatggaatcgaatg	0.000													5	3	---	---	---	---	
C10orf57	80195	broad.mit.edu	37	10	81841421	81841422	+	Intron	INS	-	A	A	rs113172526		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:81841421_81841422insA	uc001kbl.2	+						LOC219347_uc001kbk.2_5'Flank|LOC219347_uc001kbi.3_5'Flank|LOC219347_uc009xsk.2_5'Flank|LOC219347_uc009xsl.2_5'Flank|LOC219347_uc009xsm.2_5'Flank|LOC219347_uc001kbj.3_5'Flank|C10orf57_uc009xsn.2_Frame_Shift_Ins_p.S38fs|C10orf57_uc010qlv.1_Intron|C10orf57_uc010qlw.1_Intron|C10orf57_uc001kbn.3_RNA|C10orf57_uc009xsp.2_RNA|C10orf57_uc001kbo.3_Intron	NM_025125	NP_079401	Q8TBM7	CJ057_HUMAN	hypothetical protein LOC80195							integral to membrane					0	Prostate(51;0.0095)|all_epithelial(25;0.175)		Epithelial(14;0.0793)|Colorectal(32;0.109)|all cancers(16;0.154)			gagaccctgtcaaaaaaaaaag	0.158													4	7	---	---	---	---	
Unknown	0	broad.mit.edu	37	10	85395272	85395273	+	IGR	INS	-	GT	GT	rs145490120	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85395272_85395273insGT								NRG3 (648337 upstream) : GHITM (503912 downstream)																							GAACCTGTGCAgtgtgtgtgtg	0.356													5	5	---	---	---	---	
JAKMIP3	282973	broad.mit.edu	37	10	133961636	133961637	+	Intron	INS	-	TGAACA	TGAACA	rs141683861	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:133961636_133961637insTGAACA	uc001lkx.3	+						JAKMIP3_uc009yba.1_Intron	NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		ACACAAAGCCCtgaacatgaac	0.495													4	2	---	---	---	---	
CD81	975	broad.mit.edu	37	11	2415490	2415490	+	Intron	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:2415490delG	uc001lwf.1	+						CD81_uc001lwg.1_Intron|CD81_uc001lwh.1_5'Flank	NM_004356	NP_004347	P60033	CD81_HUMAN	CD81 antigen						activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding				0		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCCCTGAGGAGGGGGCAGAGC	0.652													6	5	---	---	---	---	
OR4A5	81318	broad.mit.edu	37	11	51411688	51411688	+	Frame_Shift_Del	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:51411688delG	uc001nhi.1	-	1	708	c.708delC	c.(706-708)ACCfs	p.T236fs		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	236	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				CGGAGCTGCAGGTAGACAAGG	0.408													84	41	---	---	---	---	
Unknown	0	broad.mit.edu	37	11	127462186	127462187	+	IGR	INS	-	AGG	AGG	rs146290646	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:127462186_127462187insAGG								KIRREL3 (588831 upstream) : ETS1 (866469 downstream)																							ggaaggaagaaagggagggaag	0.050													4	5	---	---	---	---	
TMPO	7112	broad.mit.edu	37	12	98914050	98914051	+	Intron	INS	-	CCTTCCTT	CCTTCCTT			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:98914050_98914051insCCTTCCTT	uc001tfj.2	+						TMPO_uc001tfi.1_Intron|TMPO_uc001tfk.2_Intron|TMPO_uc001tfl.2_Intron|TMPO_uc001tfh.1_Intron	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta							integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						CCATATTTTTCccttccttcct	0.040													4	3	---	---	---	---	
RPH3A	22895	broad.mit.edu	37	12	113116135	113116135	+	Intron	DEL	A	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113116135delA	uc010syl.1	+							NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1						intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		agaaagaaagaaggaaggaag	0.080													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	12	113492284	113492285	+	IGR	INS	-	AA	AA	rs34462445		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113492284_113492285insAA								OAS2 (42757 upstream) : DTX1 (3377 downstream)																							CTCAATGGACCAAAAAAAAAAA	0.381													6	3	---	---	---	---	
STARD13	90627	broad.mit.edu	37	13	33752145	33752160	+	Intron	DEL	AGGAAAGGAAGGAAGG	-	-	rs56269295	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33752145_33752160delAGGAAAGGAAGGAAGG	uc001uuw.2	-						STARD13_uc001uuu.2_Intron|STARD13_uc001uuv.2_Intron|STARD13_uc001uux.2_Intron|STARD13_uc010tec.1_Intron|STARD13_uc010abh.1_Intron	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		gaaggaaggaaggaaaggaaggaaggaaggaaggaa	0.102													8	4	---	---	---	---	
Unknown	0	broad.mit.edu	37	13	64499777	64499779	+	IGR	DEL	TCC	-	-	rs71824884		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:64499777_64499779delTCC								OR7E156P (183076 upstream) : None (None downstream)																							cttccttccttccttccttcctt	0.089													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	14	22616753	22616753	+	Intron	DEL	T	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22616753delT	uc001wbw.2	+						uc010aiv.1_Intron|uc010aja.1_Intron|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc010ajg.1_Intron|uc001wcx.3_Intron|uc001wdd.2_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron					SubName: Full=Alpha-chain C region; Flags: Fragment;																		CCAGAAAACATTTTCCACACA	0.493													4	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	14	95044018	95044019	+	IGR	INS	-	ATGG	ATGG			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95044018_95044019insATGG								SERPINA4 (7777 upstream) : SERPINA5 (3712 downstream)																							tggatggatgaatggatggatg	0.000													3	3	---	---	---	---	
Unknown	0	broad.mit.edu	37	15	20263577	20263578	+	IGR	INS	-	A	A	rs58110116		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:20263577_20263578insA								None (None upstream) : GOLGA6L6 (473516 downstream)																							aggaaggaaggaggaaggaagg	0.000													4	2	---	---	---	---	
HERC2P2	400322	broad.mit.edu	37	15	23312380	23312380	+	Intron	DEL	T	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23312380delT	uc001yvr.2	-						HERC2P2_uc001yvq.2_5'Flank|HERC2P2_uc001yvo.3_5'Flank|HERC2P2_uc001yvp.3_Intron					RecName: Full=Putative HERC2-like protein 3;												0						TGTTAttttcttttttttttt	0.139													7	4	---	---	---	---	
WDR72	256764	broad.mit.edu	37	15	53907719	53907719	+	Frame_Shift_Del	DEL	A	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:53907719delA	uc002acj.2	-	15	2726	c.2684delT	c.(2683-2685)TTGfs	p.L895fs	WDR72_uc010bfi.1_Frame_Shift_Del_p.L895fs	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	895										lung(1)|skin(1)	2				all cancers(107;0.0511)		TGACTCTCGCAAAGAATCACA	0.338													96	49	---	---	---	---	
RNF111	54778	broad.mit.edu	37	15	59341944	59341945	+	Intron	INS	-	TT	TT	rs60727965		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59341944_59341945insTT	uc002afv.2	+						RNF111_uc002afs.2_Intron|RNF111_uc002aft.2_Intron|RNF111_uc002afu.2_Intron|RNF111_uc002afw.2_Intron	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111						multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		ttctttctttcttttttttttt	0.168													3	3	---	---	---	---	
CIB2	10518	broad.mit.edu	37	15	78397503	78397504	+	3'UTR	INS	-	T	T	rs149170192	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78397503_78397504insT	uc002bdb.1	-	6					CIB2_uc002bdc.1_3'UTR	NM_006383	NP_006374	O75838	CIB2_HUMAN	DNA-dependent protein kinase catalytic								calcium ion binding				0						CCTGGTTAAGGTTTTTTTTTTG	0.594													4	2	---	---	---	---	
SOLH	6650	broad.mit.edu	37	16	600733	600734	+	Intron	INS	-	T	T	rs145905062	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:600733_600734insT	uc002chi.2	+						SOLH_uc002chj.2_5'Flank	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes						proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				TGAGGGTCCCCGTCGGTGAGGG	0.738													4	2	---	---	---	---	
CPPED1	55313	broad.mit.edu	37	16	12798409	12798409	+	Intron	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:12798409delG	uc002dca.3	-						CPPED1_uc002dcb.3_Intron|CPPED1_uc002dbz.3_Intron	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain								hydrolase activity|metal ion binding				0						GCAGAGAGACGGGAGAAAGAT	0.358													18	8	---	---	---	---	
LOC595101	595101	broad.mit.edu	37	16	30291742	30291742	+	Intron	DEL	A	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30291742delA	uc002dxp.1	-							NR_002453				Homo sapiens cDNA FLJ39663 fis, clone SMINT2007187.												0						AACAAAATAGAAAAAAAAAAA	0.358													6	3	---	---	---	---	
PMFBP1	83449	broad.mit.edu	37	16	72187821	72187834	+	Intron	DEL	ACACACACACACAC	-	-	rs67205706		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72187821_72187834delACACACACACACAC	uc002fcc.3	-						PMFBP1_uc002fcd.2_Intron|PMFBP1_uc002fce.2_Intron|PMFBP1_uc002fcf.2_Intron	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1											ovary(2)	2		Ovarian(137;0.179)				ATGGACTTATacacacacacacacacacacacac	0.285													4	3	---	---	---	---	
PFAS	5198	broad.mit.edu	37	17	8171707	8171707	+	Intron	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8171707delG	uc002gkr.2	+						PFAS_uc010vuv.1_Intron|PFAS_uc002gks.2_Intron	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase						'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	aaaaaaaaaagaaagaaggaa	0.095													4	2	---	---	---	---	
C17orf48	56985	broad.mit.edu	37	17	10609586	10609587	+	Intron	DEL	AT	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10609586_10609587delAT	uc002gmt.2	+						C17orf48_uc002gmu.2_Intron|C17orf48_uc002gmv.2_Intron|C17orf48_uc010vvg.1_Intron	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase								ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						ATGCAGTGTGATATATATATAT	0.337													5	4	---	---	---	---	
Unknown	0	broad.mit.edu	37	17	18304008	18304008	+	5'Flank	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18304008delG	uc010vxw.1	-						uc002gto.2_5'Flank					DQ589132																		CTGGACGCCTGGGGTGGCCAC	0.592													1	5	---	---	---	---	
Unknown	0	broad.mit.edu	37	17	46754509	46754512	+	IGR	DEL	CCTT	-	-	rs143755906		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46754509_46754512delCCTT								MIR196A1 (44588 upstream) : PRAC (44580 downstream)																							ttccttcctcccttccttccttcc	0.005													3	5	---	---	---	---	
EFCAB3	146779	broad.mit.edu	37	17	60489162	60489165	+	Intron	DEL	GGAG	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60489162_60489165delGGAG	uc002izu.1	+						EFCAB3_uc010wpc.1_Intron	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b								calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			agaaaGAGATggagggagggaggg	0.010													4	3	---	---	---	---	
CDH7	1005	broad.mit.edu	37	18	63482006	63482006	+	Intron	DEL	A	-	-	rs146003873		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:63482006delA	uc002ljz.2	+						CDH7_uc002lka.2_Intron|CDH7_uc002lkb.2_Intron	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ATCACCttttaaaaatatttt	0.239													5	3	---	---	---	---	
GRIN3B	116444	broad.mit.edu	37	19	1004702	1004702	+	Frame_Shift_Del	DEL	C	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1004702delC	uc002lqo.1	+	3	1202	c.1202delC	c.(1201-1203)GCCfs	p.A401fs		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	401	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCGGGAGGTGCCTCTGCACGG	0.687													11	7	---	---	---	---	
ATG4D	84971	broad.mit.edu	37	19	10659430	10659430	+	Intron	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10659430delG	uc002mov.2	+						ATG4D_uc010xlh.1_Intron|ATG4D_uc010dxh.2_Intron|ATG4D_uc010dxi.2_Intron|ATG4D_uc010dxj.2_Intron	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D						autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GGGGGTGTTTGGGGGGCACTA	0.368													10	5	---	---	---	---	
UNC13A	23025	broad.mit.edu	37	19	17757078	17757079	+	Intron	INS	-	TGTTTGTT	TGTTTGTT	rs142508123	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17757078_17757079insTGTTTGTT	uc002nhd.2	-							NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						Ggttttttgtgtgtttgtttgt	0.272													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	19	19970038	19970039	+	IGR	INS	-	A	A	rs34661226		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19970038_19970039insA								ZNF506 (37478 upstream) : ZNF253 (6675 downstream)																							GTTAGCTTTTCAAAAAAAAAAA	0.460													4	2	---	---	---	---	
KLK13	26085	broad.mit.edu	37	19	51567089	51567090	+	Intron	INS	-	C	C	rs2736432		TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51567089_51567090insC	uc002pvn.2	-						KLK13_uc002pvl.2_Intron|KLK13_uc002pvm.2_Intron|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Intron|KLK13_uc002pvq.2_Intron|KLK13_uc010eoo.2_Intron|KLK13_uc002pvr.2_Intron	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor						proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		acatctctaggcccctggcttg	0.074													9	5	---	---	---	---	
LILRB5	10990	broad.mit.edu	37	19	54758161	54758161	+	Intron	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54758161delG	uc002qex.2	-						LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Intron|LILRB5_uc002qey.2_Intron|LILRB5_uc002qez.2_Intron|LILRB5_uc002qfa.1_3'UTR	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,						cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TAGGATCCTCGGGGAGACTCA	0.672													4	2	---	---	---	---	
EPS8L1	54869	broad.mit.edu	37	19	55598003	55598004	+	Intron	INS	-	C	C	rs143222343	by1000genomes	TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55598003_55598004insC	uc002qis.3	+						EPS8L1_uc010yfr.1_Intron|EPS8L1_uc002qiu.2_Intron|EPS8L1_uc002qiv.2_Intron|EPS8L1_uc002qiw.2_Intron	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway							cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ACGCTGGAGCGCCCCCCCGCCC	0.470													4	3	---	---	---	---	
LOC96610	96610	broad.mit.edu	37	22	22556628	22556628	+	Intron	DEL	G	-	-			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22556628delG	uc011aim.1	+											Parts of antibodies, mostly variable regions.												0						AACTGGTTAAGAACTTCAGTG	0.363													25	17	---	---	---	---	
NAP1L3	4675	broad.mit.edu	37	X	92926883	92926884	+	Frame_Shift_Ins	INS	-	A	A			TCGA-22-4613-01	TCGA-22-4613-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:92926883_92926884insA	uc004efq.2	-	1	1725_1726	c.1420_1421insT	c.(1420-1422)GATfs	p.D474fs	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	474					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						GATGACATTATCATGTAAAATC	0.366													51	30	---	---	---	---	
