Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
COL17A1	1308	broad.mit.edu	37	10	105796299	105796299	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:105796299C>T	uc001kxr.2	-	c.3369G>A	c.(3367-3369)CTG>CTA	p.L1123L		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1123	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane				ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)										0.222222	26.870917	30.704984	12	42	KEEP	---	---	---	---	capture		Silent	SNP	105796299	105796299	3812	10	C	T	T	T	210	17	COL17A1	2	2
C10orf79	80217	broad.mit.edu	37	10	105926410	105926410	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:105926410C>T	uc001kxw.2	-	c.2875G>A	c.(2875-2877)GAT>AAT	p.D959N	C10orf79_uc009xxq.2_Missense_Mutation_p.D267N	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	959											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)										0.041841	-34.556569	19.353815	10	229	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	105926410	105926410	1655	10	C	T	T	T	377	29	C10orf79	2	2
SHOC2	8036	broad.mit.edu	37	10	112724821	112724821	+	Splice_Site_SNP	SNP	T	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:112724821T>A	uc001kzl.3	+	c.703_splice	c.e2+2	p.G235_splice	SHOC2_uc009xxx.2_Splice_Site_SNP_p.G235_splice|SHOC2_uc010qrg.1_Intron|SHOC2_uc001kzn.2_Splice_Site_SNP_p.G235_splice	NM_007373	NP_031399			soc-2 suppressor of clear homolog						fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)	1				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)										0.416667	60.492763	60.783413	20	28	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	112724821	112724821	14782	10	T	A	A	A	741	57	SHOC2	5	3
SHOC2	8036	broad.mit.edu	37	10	112764399	112764399	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:112764399G>C	uc001kzl.3	+	c.1008G>C	c.(1006-1008)TTG>TTC	p.L336F	SHOC2_uc009xxx.2_Missense_Mutation_p.L336F|SHOC2_uc010qrg.1_5'UTR|SHOC2_uc001kzn.2_Missense_Mutation_p.L290F	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	336	LRR 11.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)	1				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)										0.054054	-5.665341	9.853544	4	70	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	112764399	112764399	14782	10	G	C	C	C	581	45	SHOC2	3	3
GLRX3	10539	broad.mit.edu	37	10	131973145	131973145	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:131973145C>T	uc001lkm.1	+	c.839C>T	c.(838-840)ACA>ATA	p.T280I	GLRX3_uc001lkn.1_Missense_Mutation_p.T280I|GLRX3_uc001lko.2_Non-coding_Transcript	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	280	Glutaredoxin 2.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)										0.103226	10.971297	35.296084	16	139	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	131973145	131973145	6729	10	C	T	T	T	221	17	GLRX3	2	2
MTG1	92170	broad.mit.edu	37	10	135233655	135233655	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:135233655G>C	uc001lnd.2	+	c.991G>C	c.(991-993)GAG>CAG	p.E331Q	MTG1_uc010qve.1_Missense_Mutation_p.E196Q	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	331						mitochondrion	GTP binding|protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)										0.094737	9.296993	24.969472	9	86	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	135233655	135233655	10319	10	G	C	C	C	585	45	MTG1	3	3
CYP26C1	340665	broad.mit.edu	37	10	94828109	94828109	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:94828109G>A	uc010qns.1	+	c.1224G>A	c.(1222-1224)ATG>ATA	p.M408I	CYP26C1_uc009xud.2_Non-coding_Transcript	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	408					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|oxidation-reduction process|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)												0.1	4.028494	23.207986	12	108	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	94828109	94828109	4322	10	G	A	A	A	624	48	CYP26C1	2	2
ARHGEF12	23365	broad.mit.edu	37	11	120322385	120322385	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:120322385G>C	uc001pxl.1	+	c.2008G>C	c.(2008-2010)GCT>CCT	p.A670P	ARHGEF12_uc009zat.2_Missense_Mutation_p.A651P|ARHGEF12_uc010rzn.1_Missense_Mutation_p.A567P|ARHGEF12_uc009zau.1_Missense_Mutation_p.A567P	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	670					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)						1000				0.106383	6.238174	13.469524	5	42	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	120322385	120322385	911	11	G	C	C	C	442	34	ARHGEF12	3	3
TPH1	7166	broad.mit.edu	37	11	18048086	18048086	+	Missense_Mutation	SNP	A	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:18048086A>G	uc001mnp.2	-	c.754T>C	c.(754-756)TGC>CGC	p.C252R	TPH1_uc009yhe.2_Non-coding_Transcript	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	252					aromatic amino acid family metabolic process|hormone biosynthetic process|oxidation-reduction process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)					206				0.072072	0.010533	20.936366	8	103	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	18048086	18048086	16945	11	A	G	G	G	91	7	TPH1	4	4
GTF2H1	2965	broad.mit.edu	37	11	18354719	18354719	+	Nonsense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:18354719G>A	uc001moi.2	+	c.98G>A	c.(97-99)TGG>TAG	p.W33*	GTF2H1_uc001moh.2_Nonsense_Mutation_p.W33*|GTF2H1_uc009yhm.2_5'UTR	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	33					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	general RNA polymerase II transcription factor activity|protein binding				0														0.05848	-11.400863	23.535032	10	161	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	18354719	18354719	7140	11	G	A	A	A	611	47	GTF2H1	5	2
FIBIN	387758	broad.mit.edu	37	11	27016133	27016133	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:27016133C>T	uc001mrd.2	+	c.60C>T	c.(58-60)TTC>TTT	p.F20F		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	20						extracellular region|Golgi apparatus					0														0.1375	35.252696	55.583488	22	138	KEEP	---	---	---	---	capture		Silent	SNP	27016133	27016133	6123	11	C	T	T	T	402	31	FIBIN	1	1
OR51D1	390038	broad.mit.edu	37	11	4661548	4661548	+	Silent	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:4661548C>G	uc010qyk.1	+	c.528C>G	c.(526-528)CTC>CTG	p.L176L		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)										0.063123	-5.636541	54.1876	19	282	KEEP	---	---	---	---	capture		Silent	SNP	4661548	4661548	11503	11	C	G	G	G	366	29	OR51D1	3	3
MYBPC3	4607	broad.mit.edu	37	11	47362583	47362583	+	Missense_Mutation	SNP	T	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:47362583T>C	uc001nfa.3	-	c.1898A>G	c.(1897-1899)GAG>GGG	p.E633G	MYBPC3_uc010rhl.1_Non-coding_Transcript	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	632	Ig-like C2-type 4.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)										0.25	11.192219	12.101227	4	12	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	47362583	47362583	10408	11	T	C	C	C	702	54	MYBPC3	4	4
PRG3	10394	broad.mit.edu	37	11	57144338	57144338	+	Missense_Mutation	SNP	G	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:57144338G>T	uc001njv.1	-	c.663C>A	c.(661-663)TTC>TTA	p.F221L		NM_006093	NP_006084	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3 precursor	221	C-type lectin.				basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding				0						Melanoma(154;1456 2519 19358 45229)								0.060201	-24.500017	35.970653	18	281	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57144338	57144338	12923	11	G	T	T	T	477	37	PRG3	1	1
PRG2	5553	broad.mit.edu	37	11	57156549	57156549	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:57156549G>A	uc001njz.2	-	c.300C>T	c.(298-300)GGC>GGT	p.G100G	PRG2_uc001njw.1_Non-coding_Transcript|PRG2_uc001njx.1_Non-coding_Transcript|PRG2_uc001njy.1_Non-coding_Transcript|PRG2_uc001nka.2_Silent_p.G100G|PRG2_uc001nkb.2_Silent_p.G100G|PRG2_uc001nkd.2_Silent_p.G100G|PRG2_uc001nkc.2_Silent_p.G100G|PRG2_uc001nke.2_Silent_p.G380G	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	100					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)									0.089172	-7.525	19.29776	14	143	KEEP	---	---	---	---	capture		Silent	SNP	57156549	57156549	12922	11	G	A	A	A	587	46	PRG2	2	2
SLC22A8	9376	broad.mit.edu	37	11	62760896	62760896	+	Nonsense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:62760896C>T	uc001nwo.2	-	c.1529G>A	c.(1528-1530)TGG>TAG	p.W510*	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Nonsense_Mutation_p.W510*|SLC22A8_uc009yom.2_Nonsense_Mutation_p.W387*|SLC22A8_uc010rmm.1_Nonsense_Mutation_p.W419*|SLC22A8_uc009yon.2_Nonsense_Mutation_p.W510*	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	510	Extracellular (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			ovary(1)	1														0.075188	-1.558144	23.065376	10	123	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	62760896	62760896	14957	11	C	T	T	T	273	21	SLC22A8	5	2
RRP8	23378	broad.mit.edu	37	11	6623441	6623441	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:6623441G>C	uc001med.2	-	c.104C>G	c.(103-105)TCC>TGC	p.S35C	ILK_uc001mee.2_5'Flank|ILK_uc001mef.2_5'Flank|ILK_uc010rap.1_5'Flank|ILK_uc010raq.1_5'Flank|ILK_uc001meg.2_5'Flank|ILK_uc001meh.2_5'Flank	NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	35					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0														0.042945	-17.595799	18.900295	7	156	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	6623441	6623441	14170	11	G	C	C	C	533	41	RRP8	3	3
TYR	7299	broad.mit.edu	37	11	88911903	88911903	+	Missense_Mutation	SNP	A	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:88911903A>C	uc001pcs.2	+	c.782A>C	c.(781-783)AAC>ACC	p.N261T		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	261	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|oxidation-reduction process|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)									0.13913	33.922544	48.39107	16	99	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	88911903	88911903	17370	11	A	C	C	C	26	2	TYR	4	4
ACACB	32	broad.mit.edu	37	12	109680251	109680251	+	Missense_Mutation	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:109680251C>A	uc001tob.2	+	c.5032C>A	c.(5032-5034)CAC>AAC	p.H1678N	ACACB_uc001toc.2_Missense_Mutation_p.H1678N|ACACB_uc010sxl.1_Non-coding_Transcript|ACACB_uc001tod.2_Non-coding_Transcript|ACACB_uc010sxm.1_Missense_Mutation_p.H344N	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1678					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|pancreas(1)	6					Biotin(DB00121)					1843				0.054299	-24.092747	22.242875	12	209	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	109680251	109680251	108	12	C	A	A	A	377	29	ACACB	2	2
ALDH2	217	broad.mit.edu	37	12	112230500	112230500	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:112230500G>A	uc001tst.2	+	c.997G>A	c.(997-999)GAT>AAT	p.D333N	ALDH2_uc010syi.1_Missense_Mutation_p.D286N|ALDH2_uc009zvy.2_Missense_Mutation_p.D257N	NM_000690	NP_000681	P05091	ALDH2_HUMAN	mitochondrial aldehyde dehydrogenase 2	333					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase (NAD) activity|electron carrier activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)									0.12	3.50667	7.048995	3	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	112230500	112230500	499	12	G	A	A	A	585	45	ALDH2	2	2
TMEM132B	114795	broad.mit.edu	37	12	126138200	126138200	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:126138200C>T	uc001uhe.1	+	c.2181C>T	c.(2179-2181)GTC>GTT	p.V727V	TMEM132B_uc001uhf.1_Silent_p.V239V	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	727	Extracellular (Potential).					integral to membrane				ovary(5)|large_intestine(1)|breast(1)|pancreas(1)	8	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)										0.268722	170.882505	181.836269	61	166	KEEP	---	---	---	---	capture		Silent	SNP	126138200	126138200	16577	12	C	T	T	T	405	32	TMEM132B	2	2
SPRYD4	283377	broad.mit.edu	37	12	56862988	56862988	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:56862988C>G	uc001sli.3	+	c.251C>G	c.(250-252)ACC>AGC	p.T84S	SPRYD4_uc010sqo.1_Intron	NM_207344	NP_997227	Q8WW59	SPRY4_HUMAN	SPRY domain containing 4	84	B30.2/SPRY.					nucleus					0														0.051643	-18.645734	26.6535	11	202	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	56862988	56862988	15624	12	C	G	G	G	234	18	SPRYD4	3	3
LRP1	4035	broad.mit.edu	37	12	57594926	57594926	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:57594926G>A	uc001snd.2	+	c.10335G>A	c.(10333-10335)GAG>GAA	p.E3445E		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3445	Extracellular (Potential).|LDL-receptor class A 23.				apoptotic cell clearance|multicellular organismal development|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein particle receptor binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(7)|large_intestine(2)|pancreas(2)|skin(1)|central_nervous_system(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)					1456				0.065041	-14.906779	33.4489	16	230	KEEP	---	---	---	---	capture		Silent	SNP	57594926	57594926	9324	12	G	A	A	A	425	33	LRP1	2	2
DCTN2	10540	broad.mit.edu	37	12	57927771	57927771	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:57927771G>A	uc009zpu.1	-	c.649C>T	c.(649-651)CGG>TGG	p.R217W	DCTN2_uc009zpv.1_Missense_Mutation_p.R125W|DCTN2_uc009zpw.1_Missense_Mutation_p.R125W|DCTN2_uc001som.1_Missense_Mutation_p.R212W|DCTN2_uc001soo.1_Non-coding_Transcript|DCTN2_uc001son.1_Missense_Mutation_p.R125W|DCTN2_uc001sop.1_Missense_Mutation_p.R125W|DCTN2_uc001soq.1_Non-coding_Transcript|DCTN2_uc009zpx.1_Missense_Mutation_p.R212W	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	212					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule	motor activity|protein binding			ovary(1)	1														0.080645	0.949378	23.182541	10	114	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57927771	57927771	4478	12	G	A	A	A	480	37	DCTN2	1	1
PLEKHG6	55200	broad.mit.edu	37	12	6424195	6424195	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:6424195G>A	uc001qnr.2	+	c.319G>A	c.(319-321)GAG>AAG	p.E107K	PLEKHG6_uc001qns.2_Missense_Mutation_p.E107K|PLEKHG6_uc010sew.1_Missense_Mutation_p.E107K|PLEKHG6_uc010sex.1_Missense_Mutation_p.E75K	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	107					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1														0.067039	-9.288756	25.453022	12	167	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	6424195	6424195	12500	12	G	A	A	A	533	41	PLEKHG6	2	2
A2M	2	broad.mit.edu	37	12	9232408	9232408	+	Missense_Mutation	SNP	T	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:9232408T>C	uc001qvk.1	-	c.2858A>G	c.(2857-2859)GAC>GGC	p.D953G	A2M_uc001qvj.1_5'UTR|A2M_uc009zgk.1_Missense_Mutation_p.D803G	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	953					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)	4					Bacitracin(DB00626)|Becaplermin(DB00102)									0.147059	12.754336	16.820543	5	29	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	9232408	9232408	5	12	T	C	C	C	754	58	A2M	4	4
TNFRSF19	55504	broad.mit.edu	37	13	24200845	24200845	+	Splice_Site_SNP	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:24200845G>C	uc001uov.1	+	c.360_splice	c.e5-1	p.G120_splice	TNFRSF19_uc001uot.2_Splice_Site_SNP_p.G120_splice|TNFRSF19_uc010tcu.1_Splice_Site_SNP|TNFRSF19_uc001uow.2_Splice_Site_SNP_p.G120_splice	NM_018647	NP_061117			tumor necrosis factor receptor superfamily,						apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)	1		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)										0.113208	9.20874	17.0346	6	47	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	24200845	24200845	16833	13	G	C	C	C	429	33	TNFRSF19	5	3
ATP12A	479	broad.mit.edu	37	13	25284699	25284699	+	Silent	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:25284699G>C	uc010aaa.2	+	c.2883G>C	c.(2881-2883)CGG>CGC	p.R961R	ATP12A_uc001upp.2_Silent_p.R955R	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	955	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	Pancreas(156;1582 1935 18898 22665 26498)								0.103896	23.906885	47.930541	16	138	KEEP	---	---	---	---	capture		Silent	SNP	25284699	25284699	1141	13	G	C	C	C	522	41	ATP12A	3	3
TRPC4	7223	broad.mit.edu	37	13	38357157	38357157	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:38357157C>G	uc010abx.2	-	c.314G>C	c.(313-315)AGA>ACA	p.R105T	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.R105T|TRPC4_uc001uws.2_Missense_Mutation_p.R105T|TRPC4_uc010tey.1_Missense_Mutation_p.R105T|TRPC4_uc010abw.2_Missense_Mutation_p.R105T|TRPC4_uc010aby.2_Missense_Mutation_p.R105T	NM_003306	NP_003297	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	105	ANK 3.|Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|breast(1)	4				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)										0.0625	-1.756056	11.011436	4	60	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	38357157	38357157	17131	13	C	G	G	G	416	32	TRPC4	3	3
HECTD1	25831	broad.mit.edu	37	14	31602521	31602521	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:31602521C>T	uc001wrc.1	-	c.3845G>A	c.(3844-3846)AGA>AAA	p.R1282K	HECTD1_uc001wrd.1_Missense_Mutation_p.R797K	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1282	MIB/HERC2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)										0.147727	24.212236	34.701465	13	75	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	31602521	31602521	7322	14	C	T	T	T	416	32	HECTD1	2	2
AKAP6	9472	broad.mit.edu	37	14	33293407	33293407	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:33293407G>C	uc001wrq.2	+	c.6388G>C	c.(6388-6390)GAA>CAA	p.E2130Q		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2130					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|large_intestine(2)|lung(2)|pancreas(1)	16	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		Melanoma(49;821 1200 7288 13647 42351)				483				0.084746	5.340427	26.050019	10	108	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	33293407	33293407	458	14	G	C	C	C	429	33	AKAP6	3	3
GCH1	2643	broad.mit.edu	37	14	55312565	55312565	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:55312565C>G	uc001xbh.1	-	c.547G>C	c.(547-549)GAG>CAG	p.E183Q	GCH1_uc001xbi.1_Missense_Mutation_p.E183Q|GCH1_uc001xbj.1_Missense_Mutation_p.E183Q|GCH1_uc001xbk.1_Missense_Mutation_p.E183Q|GCH1_uc010aol.1_Intron|GCH1_uc001xbl.1_Missense_Mutation_p.E183Q	NM_001024024	NP_001019195	P30793	GCH1_HUMAN	GTP cyclohydrolase 1 isoform 1	183					dopamine biosynthetic process|GTP catabolic process|neuromuscular process controlling posture|nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|protein homooligomerization|response to interferon-gamma|response to lipopolysaccharide|response to pain|response to tumor necrosis factor|tetrahydrobiopterin biosynthetic process|tetrahydrofolate biosynthetic process	cytoplasmic vesicle|cytosol|nuclear membrane|protein complex	GTP binding|GTP cyclohydrolase I activity|protein homodimerization activity|zinc ion binding				0						Pancreas(198;1245 2204 4807 21567 38372)								0.068027	-2.260732	26.118137	10	137	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	55312565	55312565	6557	14	C	G	G	G	390	30	GCH1	3	3
EXD2	55218	broad.mit.edu	37	14	69697274	69697274	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:69697274C>G	uc001xkv.2	+	c.676C>G	c.(676-678)CGT>GGT	p.R226G	EXD2_uc001xkt.2_Missense_Mutation_p.R101G|EXD2_uc001xku.2_5'UTR|EXD2_uc001xkw.2_Missense_Mutation_p.R101G|EXD2_uc001xkx.2_Non-coding_Transcript|EXD2_uc010aqt.2_Missense_Mutation_p.R226G|EXD2_uc010tte.1_Missense_Mutation_p.R226G|EXD2_uc001xky.2_Missense_Mutation_p.R101G	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	101	3'-5' exonuclease.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0														0.087379	15.186978	50.679517	18	188	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	69697274	69697274	5491	14	C	G	G	G	403	31	EXD2	3	3
SERPINA5	5104	broad.mit.edu	37	14	95058516	95058516	+	Silent	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:95058516C>A	uc001ydm.2	+	c.1161C>A	c.(1159-1161)CCC>CCA	p.P387P	SERPINA3_uc001ydo.3_Intron	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	387					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)									0.138571	126.174268	214.740464	97	603	KEEP	---	---	---	---	capture		Silent	SNP	95058516	95058516	14580	14	C	A	A	A	301	24	SERPINA5	2	2
OCA2	4948	broad.mit.edu	37	15	28260068	28260068	+	Missense_Mutation	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:28260068C>A	uc001zbh.3	-	c.898G>T	c.(898-900)GTG>TTG	p.V300L	OCA2_uc010ayv.2_Missense_Mutation_p.V300L	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	300	Extracellular (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)										0.264706	23.574157	25.266392	9	25	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	28260068	28260068	11220	15	C	A	A	A	234	18	OCA2	2	2
SPG11	80208	broad.mit.edu	37	15	44914530	44914530	+	Nonsense_Mutation	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:44914530C>A	uc001ztx.2	-	c.2332G>T	c.(2332-2334)GAA>TAA	p.E778*	SPG11_uc010ueh.1_Nonsense_Mutation_p.E778*|SPG11_uc010uei.1_Nonsense_Mutation_p.E778*|SPG11_uc001ztz.1_5'Flank	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	778	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)	4		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)										0.075	-1.007495	6.406731	3	37	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	44914530	44914530	15553	15	C	A	A	A	416	32	SPG11	5	2
MYO5A	4644	broad.mit.edu	37	15	52645805	52645805	+	Silent	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:52645805G>C	uc002aby.2	-	c.3618C>G	c.(3616-3618)CTC>CTG	p.L1206L	MYO5A_uc002abx.3_Silent_p.L1206L|MYO5A_uc010ugd.1_5'Flank|MYO5A_uc002aca.1_5'Flank|MYO5A_uc002acb.1_5'Flank|MYO5A_uc002acc.1_5'Flank	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1206	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)										0.043103	-11.930993	14.035406	5	111	KEEP	---	---	---	---	capture		Silent	SNP	52645805	52645805	10473	15	G	C	C	C	574	45	MYO5A	3	3
PHLPP2	23035	broad.mit.edu	37	16	71713353	71713353	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:71713353C>T	uc002fax.2	-	c.976G>A	c.(976-978)GAG>AAG	p.E326K	PHLPP2_uc002fav.2_Non-coding_Transcript|PHLPP2_uc010cgf.2_Missense_Mutation_p.E326K|PHLPP2_uc002fay.1_Missense_Mutation_p.E326K	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	326	LRR 4.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)	1														0.09434	4.661793	22.194175	10	96	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	71713353	71713353	12279	16	C	T	T	T	377	29	PHLPP2	2	2
C17orf39	79018	broad.mit.edu	37	17	17948480	17948480	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:17948480C>G	uc002gsg.1	+	c.458C>G	c.(457-459)TCT>TGT	p.S153C		NM_024052	NP_076957	Q8IVV7	CQ039_HUMAN	hypothetical protein LOC79018	153											0	all_neural(463;0.228)													0.081081	2.888156	16.12093	6	68	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	17948480	17948480	1911	17	C	G	G	G	416	32	C17orf39	3	3
ALDH3A1	218	broad.mit.edu	37	17	19641686	19641686	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:19641686G>C	uc010cqu.2	-	c.1297C>G	c.(1297-1299)CTG>GTG	p.L433V	ALDH3A1_uc010vzd.1_Missense_Mutation_p.L433V|ALDH3A1_uc002gwj.2_Missense_Mutation_p.L433V|ALDH3A1_uc010cqv.2_Missense_Mutation_p.L432V|ALDH3A1_uc002gwk.2_Missense_Mutation_p.L550V|ALDH3A1_uc002gwl.1_Missense_Mutation_p.L360V	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	433					cellular aldehyde metabolic process|oxidation-reduction process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)									0.154762	93.657968	122.356338	39	213	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	19641686	19641686	500	17	G	C	C	C	425	33	ALDH3A1	3	3
CCDC47	57003	broad.mit.edu	37	17	61843460	61843460	+	Nonsense_Mutation	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:61843460C>A	uc002jbs.3	-	c.76G>T	c.(76-78)GAG>TAG	p.E26*	CCDC47_uc010ddx.2_Nonsense_Mutation_p.E26*|CCDC47_uc002jbt.2_Nonsense_Mutation_p.E26*	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	26						integral to membrane	protein binding				0														0.074074	-7.862615	37.459723	18	225	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	61843460	61843460	2941	17	C	A	A	A	377	29	CCDC47	5	2
AZI1	22994	broad.mit.edu	37	17	79168681	79168681	+	Missense_Mutation	SNP	A	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:79168681A>G	uc002jzp.1	-	c.2117T>C	c.(2116-2118)GTC>GCC	p.V706A	AZI1_uc002jzm.1_Missense_Mutation_p.V133A|AZI1_uc002jzn.1_Missense_Mutation_p.V703A|AZI1_uc002jzo.1_Missense_Mutation_p.V703A|AZI1_uc010wum.1_Missense_Mutation_p.V706A|AZI1_uc002jzq.2_5'Flank	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	706					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)											0.088292	26.940437	116.247738	46	475	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	79168681	79168681	1261	17	A	G	G	G	130	10	AZI1	4	4
DSC1	1823	broad.mit.edu	37	18	28712647	28712647	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:28712647G>A	uc002kwn.2	-	c.2122C>T	c.(2122-2124)CTG>TTG	p.L708L	DSC1_uc002kwm.2_Silent_p.L708L	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	708	Helical; (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)	3			OV - Ovarian serous cystadenocarcinoma(10;0.00778)											0.176471	12.527436	15.88263	6	28	KEEP	---	---	---	---	capture		Silent	SNP	28712647	28712647	4949	18	G	A	A	A	425	33	DSC1	2	2
MOCOS	55034	broad.mit.edu	37	18	33775270	33775270	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:33775270C>T	uc002kzq.3	+	c.193C>T	c.(193-195)CTC>TTC	p.L65F		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	65					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)									0.099237	11.268097	32.309779	13	118	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	33775270	33775270	10080	18	C	T	T	T	364	28	MOCOS	2	2
RNF152	220441	broad.mit.edu	37	18	59483267	59483267	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:59483267C>T	uc002lih.1	-	c.430G>A	c.(430-432)GGT>AGT	p.G144S		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	144					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)												0.061538	-3.556375	9.484793	4	61	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	59483267	59483267	13930	18	C	T	T	T	312	24	RNF152	2	2
ZNF99	7652	broad.mit.edu	37	19	22941400	22941400	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:22941400G>A	uc010xrh.1	-	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F		NM_001080409	NP_001073878	A8MXY4	ZNF99_HUMAN	zinc finger protein 99	346	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)												0.115385	8.109469	15.687862	6	46	KEEP	---	---	---	---	capture		Silent	SNP	22941400	22941400	18808	19	G	A	A	A	425	33	ZNF99	2	2
ZNF536	9745	broad.mit.edu	37	19	30936293	30936293	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:30936293G>A	uc002nsu.1	+	c.1824G>A	c.(1822-1824)TTG>TTA	p.L608L	ZNF536_uc010edd.1_Silent_p.L608L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	608					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)	9	Esophageal squamous(110;0.0834)													0.117021	20.415066	47.54544	22	166	KEEP	---	---	---	---	capture		Silent	SNP	30936293	30936293	18568	19	G	A	A	A	620	48	ZNF536	2	2
ALKBH6	84964	broad.mit.edu	37	19	36501474	36501474	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:36501474C>T	uc002ocv.1	-	c.532G>A	c.(532-534)GAA>AAA	p.E178K	C19orf46_uc002ocr.1_5'Flank|C19orf46_uc002ocs.1_5'Flank|C19orf46_uc002ocq.1_5'Flank|C19orf46_uc010een.1_5'Flank|ALKBH6_uc002oct.2_Missense_Mutation_p.E150K|ALKBH6_uc002ocx.1_Missense_Mutation_p.E81K|ALKBH6_uc002ocw.1_3'UTR|ALKBH6_uc010eeo.1_Missense_Mutation_p.E150K|ALKBH6_uc010eep.1_3'UTR	NM_032878	NP_116267	Q3KRA9	ALKB6_HUMAN	alkB, alkylation repair homolog 6 isoform 2	150	Fe2OG dioxygenase.				oxidation-reduction process	cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_lung(56;1.35e-06)|Lung NSC(56;2.15e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)											0.060606	-8.602372	18.017196	8	124	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	36501474	36501474	534	19	C	T	T	T	416	32	ALKBH6	2	2
ZNF227	7770	broad.mit.edu	37	19	44740468	44740468	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:44740468G>C	uc002oyu.2	+	c.1885G>C	c.(1885-1887)GAG>CAG	p.E629Q	ZNF227_uc010xwu.1_Missense_Mutation_p.E578Q|ZNF227_uc002oyv.2_Missense_Mutation_p.E629Q|ZNF227_uc010xwv.1_Missense_Mutation_p.E578Q|ZNF227_uc010xww.1_Missense_Mutation_p.E550Q|ZNF227_uc002oyw.2_Missense_Mutation_p.E601Q|ZNF227_uc010ejh.2_Missense_Mutation_p.E622Q|ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_3'UTR	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	629					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)												0.059701	-5.253916	8.344859	4	63	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	44740468	44740468	18372	19	G	C	C	C	429	33	ZNF227	3	3
NLRP13	126204	broad.mit.edu	37	19	56424091	56424091	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:56424091C>G	uc010ygg.1	-	c.1092G>C	c.(1090-1092)AAG>AAC	p.K364N		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	364	NACHT.						ATP binding			ovary(3)|skin(2)|pancreas(1)|lung(1)	7		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)										0.125714	39.621194	63.56323	22	153	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	56424091	56424091	10878	19	C	G	G	G	415	32	NLRP13	3	3
WDR47	22911	broad.mit.edu	37	1	109525326	109525326	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:109525326C>G	uc001dwl.2	-	c.2195G>C	c.(2194-2196)GGA>GCA	p.G732A	WDR47_uc001dwi.2_Missense_Mutation_p.G725A|WDR47_uc001dwj.2_Missense_Mutation_p.G724A|WDR47_uc010ovf.1_Missense_Mutation_p.G649A	NM_001142550	NP_001136022	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 1	724	WD 3.									ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)										0.034146	-31.345003	17.090711	7	198	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	109525326	109525326	17873	1	C	G	G	G	390	30	WDR47	3	3
CD53	963	broad.mit.edu	37	1	111434033	111434033	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:111434033G>A	uc001dzw.2	+	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CD53_uc001dzx.2_Missense_Mutation_p.M1I|CD53_uc010owa.1_Missense_Mutation_p.M1I|CD53_uc001dzy.2_Missense_Mutation_p.M1I	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	1	Cytoplasmic (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)										0.053846	-13.09205	14.211942	7	123	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	111434033	111434033	3151	1	G	A	A	A	611	47	CD53	2	2
HIPK1	204851	broad.mit.edu	37	1	114483059	114483059	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:114483059C>G	uc001eem.2	+	c.54C>G	c.(52-54)TTC>TTG	p.F18L	HIPK1_uc001eel.2_Missense_Mutation_p.F18L|HIPK1_uc001een.2_Missense_Mutation_p.F18L	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	18					protein phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)						365				0.05597	-30.924289	80.207839	30	506	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	114483059	114483059	7401	1	C	G	G	G	415	32	HIPK1	3	3
CSDE1	7812	broad.mit.edu	37	1	115273174	115273174	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:115273174C>T	uc001efi.2	-	c.1284G>A	c.(1282-1284)GGG>GGA	p.G428G	CSDE1_uc001efj.2_Non-coding_Transcript|CSDE1_uc001efk.2_Silent_p.G382G|CSDE1_uc001efl.2_Silent_p.G351G|CSDE1_uc001efm.2_Silent_p.G397G|CSDE1_uc009wgv.2_Silent_p.G382G|CSDE1_uc001efn.2_Silent_p.G351G	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	382	CSD 5.			IKCVDRDVRMFFHFSEILDGNQL -> HPSVWIRECSVCSF PLPVKFWMGTSS (in Ref. 2; AAD27787).	male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)										0.06015	-10.514663	16.393691	8	125	KEEP	---	---	---	---	capture		Silent	SNP	115273174	115273174	4070	1	C	T	T	T	379	30	CSDE1	2	2
INTS3	65123	broad.mit.edu	37	1	153745528	153745528	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:153745528G>A	uc009wom.2	+	c.3022G>A	c.(3022-3024)GAA>AAA	p.E1008K	INTS3_uc001fct.2_Missense_Mutation_p.E1008K|INTS3_uc001fcu.2_Missense_Mutation_p.E700K|INTS3_uc001fcv.2_Missense_Mutation_p.E802K|INTS3_uc010peb.1_Missense_Mutation_p.E868K|INTS3_uc001fcw.2_Missense_Mutation_p.E521K|INTS3_uc010pec.1_Missense_Mutation_p.E521K|INTS3_uc001fcy.2_Missense_Mutation_p.E371K|INTS3_uc001fcx.2_Missense_Mutation_p.E305K	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	1009					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)	2	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)											0.121212	44.137937	85.866324	36	261	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	153745528	153745528	8080	1	G	A	A	A	481	37	INTS3	1	1
ADAM15	8751	broad.mit.edu	37	1	155029447	155029447	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:155029447C>T	uc001fgr.1	+	c.1018C>T	c.(1018-1020)CTG>TTG	p.L340L	ADAM15_uc001fgq.1_Silent_p.L25L|ADAM15_uc010pet.1_Silent_p.L324L|ADAM15_uc010peu.1_Silent_p.L357L|ADAM15_uc001fgt.1_Silent_p.L340L|ADAM15_uc010pev.1_Silent_p.L350L|ADAM15_uc001fgs.1_Silent_p.L340L|ADAM15_uc001fgu.1_Silent_p.L340L|ADAM15_uc001fgw.1_Silent_p.L340L|ADAM15_uc001fgv.1_Silent_p.L340L|ADAM15_uc001fgx.1_Silent_p.L340L|ADAM15_uc001fgz.1_Non-coding_Transcript|ADAM15_uc001fgy.1_Non-coding_Transcript|ADAM15_uc001fha.1_Non-coding_Transcript|ADAM15_uc001fhb.1_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	340	Peptidase M12B.|Extracellular (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)											0.106383	14.35243	36.242626	15	126	KEEP	---	---	---	---	capture		Silent	SNP	155029447	155029447	238	1	C	T	T	T	311	24	ADAM15	2	2
GBA	2629	broad.mit.edu	37	1	155207965	155207965	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:155207965C>T	uc001fjh.2	-	c.721G>A	c.(721-723)GGA>AGA	p.G241R	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Missense_Mutation_p.G128R|GBA_uc010pfx.1_Missense_Mutation_p.G192R|GBA_uc001fji.2_Missense_Mutation_p.G241R|GBA_uc001fjj.2_Missense_Mutation_p.G241R|GBA_uc001fjk.2_Missense_Mutation_p.G241R|GBA_uc001fjl.2_Missense_Mutation_p.G241R|GBA_uc010pfy.1_Missense_Mutation_p.G154R|GBA_uc009wqk.1_Missense_Mutation_p.G154R	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	241			G -> E (in GD).|G -> R (in GD; type 1 and type 2; gene conversion).		carbohydrate metabolic process|cell death|lysosome organization|sphingolipid metabolic process	lysosomal membrane	cation binding|glucosylceramidase activity|protein binding			ovary(1)	1	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)									0.085106	3.532617	19.938679	8	86	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	155207965	155207965	6532	1	C	T	T	T	299	23	GBA	1	1
SPTA1	6708	broad.mit.edu	37	1	158587342	158587342	+	Missense_Mutation	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:158587342C>A	uc001fst.1	-	c.6585G>T	c.(6583-6585)CAG>CAT	p.Q2195H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2195	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|breast(1)	5	all_hematologic(112;0.0378)													0.111111	6.106732	14.184846	6	48	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	158587342	158587342	15630	1	C	A	A	A	363	28	SPTA1	2	2
CRP	1401	broad.mit.edu	37	1	159683874	159683874	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:159683874G>A	uc001ftw.2	-	c.116C>T	c.(115-117)TCC>TTC	p.S39F	CRP_uc001ftx.1_Missense_Mutation_p.S39F|CRP_uc001fty.1_5'Flank	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	39	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)					63				0.043956	-24.149686	16.375549	8	174	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	159683874	159683874	4034	1	G	A	A	A	533	41	CRP	2	2
SH2D1B	117157	broad.mit.edu	37	1	162381712	162381712	+	Missense_Mutation	SNP	T	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:162381712T>C	uc001gbz.1	-	c.95A>G	c.(94-96)GAC>GGC	p.D32G	SH2D1B_uc001gca.1_Missense_Mutation_p.D32G	NM_053282	NP_444512	O14796	SH21B_HUMAN	SH2 domain containing 1B	32	SH2.									pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)											0.126582	15.59746	26.348826	10	69	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	162381712	162381712	14722	1	T	C	C	C	754	58	SH2D1B	4	4
BAT2L2	23215	broad.mit.edu	37	1	171511180	171511180	+	Silent	SNP	A	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:171511180A>G	uc010pmg.1	+	c.4569A>G	c.(4567-4569)ACA>ACG	p.T1523T	BAT2L2_uc010pmh.1_Silent_p.T500T	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1523							protein C-terminus binding				0														0.093023	6.142121	20.463815	8	78	KEEP	---	---	---	---	capture		Silent	SNP	171511180	171511180	1342	1	A	G	G	G	80	7	BAT2L2	4	4
LAMC2	3918	broad.mit.edu	37	1	183208591	183208591	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:183208591G>C	uc001gqa.2	+	c.2962G>C	c.(2962-2964)GAC>CAC	p.D988H	LAMC2_uc001gpz.3_Missense_Mutation_p.D988H|LAMC2_uc010poa.1_Missense_Mutation_p.D688H	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	988	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			ovary(1)	1														0.111111	52.549833	96.959913	33	264	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	183208591	183208591	8938	1	G	C	C	C	585	45	LAMC2	3	3
UBR4	23352	broad.mit.edu	37	1	19401370	19401370	+	Missense_Mutation	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:19401370C>A	uc001bbi.2	-	c.15508G>T	c.(15508-15510)GAT>TAT	p.D5170Y	UBR4_uc001bbe.1_Non-coding_Transcript|UBR4_uc001bbf.2_Missense_Mutation_p.D65Y|UBR4_uc010ocv.1_Missense_Mutation_p.D693Y|UBR4_uc009vph.2_Missense_Mutation_p.D825Y|UBR4_uc010ocw.1_Missense_Mutation_p.D834Y|UBR4_uc001bbg.2_Missense_Mutation_p.D881Y|UBR4_uc001bbh.2_Missense_Mutation_p.D879Y	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	5170					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)	23		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)										0.122449	8.114866	14.955857	6	43	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	19401370	19401370	17462	1	C	A	A	A	403	31	UBR4	1	1
KIF21B	23046	broad.mit.edu	37	1	200972738	200972738	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:200972738C>T	uc001gvs.1	-	c.1188G>A	c.(1186-1188)CAG>CAA	p.Q396Q	KIF21B_uc001gvr.1_Silent_p.Q396Q|KIF21B_uc009wzl.1_Silent_p.Q396Q|KIF21B_uc010ppn.1_Silent_p.Q396Q|KIF21B_uc001gvt.1_Silent_p.Q254Q	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	396	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3														0.130435	23.441993	38.722251	15	100	KEEP	---	---	---	---	capture		Silent	SNP	200972738	200972738	8600	1	C	T	T	T	415	32	KIF21B	2	2
PTPN14	5784	broad.mit.edu	37	1	214568286	214568286	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:214568286G>A	uc001hkk.1	-	c.802C>T	c.(802-804)CTA>TTA	p.L268L	PTPN14_uc010pty.1_Silent_p.L169L	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	268	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		Colon(92;557 1424 24372 34121 40073)								0.04878	-30.063076	23.442631	12	234	KEEP	---	---	---	---	capture		Silent	SNP	214568286	214568286	13238	1	G	A	A	A	425	33	PTPN14	2	2
GNL2	29889	broad.mit.edu	37	1	38048524	38048524	+	Nonsense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:38048524G>C	uc001cbk.2	-	c.650C>G	c.(649-651)TCA>TGA	p.S217*	GNL2_uc010oif.1_Nonsense_Mutation_p.S58*	NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	217					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)												0.0625	-1.912576	23.621877	8	120	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	38048524	38048524	6805	1	G	C	C	C	585	45	GNL2	5	3
FOXJ3	22887	broad.mit.edu	37	1	42744180	42744180	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:42744180C>G	uc001che.2	-	c.208G>C	c.(208-210)GAA>CAA	p.E70Q	FOXJ3_uc001chf.2_Missense_Mutation_p.E70Q|FOXJ3_uc001chg.2_Missense_Mutation_p.E70Q|FOXJ3_uc001chh.1_Missense_Mutation_p.E70Q	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	70					embryo development|negative regulation of gene-specific transcription from RNA polymerase II promoter|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)												0.060976	-11.187515	54.837616	20	308	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	42744180	42744180	6259	1	C	G	G	G	416	32	FOXJ3	3	3
LEPRE1	64175	broad.mit.edu	37	1	43215957	43215957	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:43215957G>A	uc001chx.3	-	c.1620C>T	c.(1618-1620)AAC>AAT	p.N540N	LEPRE1_uc001chv.2_Silent_p.N540N|LEPRE1_uc001chw.2_Silent_p.N540N	NM_001146289	NP_001139761	Q32P28	P3H1_HUMAN	leprecan 1 isoform 2	540					negative regulation of cell proliferation|oxidation-reduction process	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)									0.083333	-0.13669	8.334993	4	44	KEEP	---	---	---	---	capture		Silent	SNP	43215957	43215957	9053	1	G	A	A	A	516	40	LEPRE1	1	1
CPT2	1376	broad.mit.edu	37	1	53676597	53676597	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:53676597C>T	uc001cvb.3	+	c.1251C>T	c.(1249-1251)TTC>TTT	p.F417F		NM_000098	NP_000089	P23786	CPT2_HUMAN	carnitine O-palmitoyltransferase precursor	417	Mitochondrial matrix (By similarity).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity				0					L-Carnitine(DB00583)|Perhexiline(DB01074)									0.078125	-2.478736	9.188286	5	59	KEEP	---	---	---	---	capture		Silent	SNP	53676597	53676597	3973	1	C	T	T	T	402	31	CPT2	1	1
LPHN2	23266	broad.mit.edu	37	1	82456080	82456080	+	Missense_Mutation	SNP	T	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:82456080T>C	uc001dit.3	+	c.3463T>C	c.(3463-3465)TCA>CCA	p.S1155P	LPHN2_uc001dis.2_Missense_Mutation_p.S135P|LPHN2_uc001diu.2_Missense_Mutation_p.S1155P|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_Silent_p.I1122I|LPHN2_uc001diw.2_Missense_Mutation_p.S782P	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1211	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(2)|central_nervous_system(1)	3				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)										0.054852	-13.424833	36.029893	13	224	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	82456080	82456080	9289	1	T	C	C	C	806	62	LPHN2	4	4
ARHGAP29	9411	broad.mit.edu	37	1	94639514	94639514	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:94639514G>C	uc001dqj.3	-	c.3697C>G	c.(3697-3699)CCT>GCT	p.P1233A	ARHGAP29_uc009wdq.1_Intron	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	1233					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|ovary(1)	10		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)						391				0.061404	-8.684977	37.035531	14	214	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	94639514	94639514	890	1	G	C	C	C	546	42	ARHGAP29	3	3
EDEM2	55741	broad.mit.edu	37	20	33722746	33722746	+	Missense_Mutation	SNP	T	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:33722746T>A	uc002xbo.2	-	c.497A>T	c.(496-498)CAG>CTG	p.Q166L	EDEM2_uc010zuv.1_Missense_Mutation_p.Q125L|EDEM2_uc010zus.1_5'UTR|EDEM2_uc002xbq.2_Missense_Mutation_p.Q129L|EDEM2_uc010zut.1_Missense_Mutation_p.Q125L|EDEM2_uc002xbp.2_Missense_Mutation_p.Q14L|EDEM2_uc002xbn.2_Missense_Mutation_p.Q14L|EDEM2_uc002xbr.2_Non-coding_Transcript|EDEM2_uc010zuu.1_Intron	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	166					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			Esophageal Squamous(51;906 1021 24535 36410 39145)								0.233333	36.218628	40.124564	14	46	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	33722746	33722746	5099	20	T	A	A	A	715	55	EDEM2	3	3
PLCG1	5335	broad.mit.edu	37	20	39795229	39795229	+	Missense_Mutation	SNP	C	G	G	rs35351109		TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:39795229C>G	uc002xjo.1	+	c.2114C>G	c.(2113-2115)TCT>TGT	p.S705C	PLCG1_uc002xjp.1_Missense_Mutation_p.S705C|PLCG1_uc010zwe.1_Missense_Mutation_p.S331C|PLCG1_uc010ggf.2_Missense_Mutation_p.S55C	NM_002660	NP_002651	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform a	705	SH2 2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(3)|lung(2)|skin(1)	6		Myeloproliferative disorder(115;0.00878)								429				0.050725	-10.498199	19.016859	7	131	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	39795229	39795229	12461	20	C	G	G	G	416	32	PLCG1	3	3
MCM5	4174	broad.mit.edu	37	22	35802587	35802587	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:35802587C>T	uc003anu.3	+	c.465C>T	c.(463-465)ATC>ATT	p.I155I	MCM5_uc010gwr.2_5'UTR|MCM5_uc003anv.3_Silent_p.I112I|MCM5_uc010gws.1_5'Flank	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	155					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1														0.070423	-3.487045	10.037858	5	66	KEEP	---	---	---	---	capture		Silent	SNP	35802587	35802587	9779	22	C	T	T	T	369	29	MCM5	2	2
MYH9	4627	broad.mit.edu	37	22	36737460	36737460	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:36737460G>C	uc003apg.2	-	c.445C>G	c.(445-447)CAC>GAC	p.H149D	MYH9_uc003aph.1_Missense_Mutation_p.H13D|MYH9_uc003api.1_Missense_Mutation_p.H149D	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	149	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	10										1624				0.05814	-7.298772	27.90446	10	162	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	36737460	36737460	10437	22	G	C	C	C	585	45	MYH9	3	3
TBC1D22A	25771	broad.mit.edu	37	22	47274580	47274580	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:47274580C>G	uc003bib.2	+	c.669C>G	c.(667-669)ATC>ATG	p.I223M	TBC1D22A_uc010haf.2_Missense_Mutation_p.I193M|TBC1D22A_uc003bic.2_Missense_Mutation_p.I164M|TBC1D22A_uc003bie.2_Missense_Mutation_p.I145M|TBC1D22A_uc003bid.2_Intron|TBC1D22A_uc010hag.2_Non-coding_Transcript|TBC1D22A_uc003bif.2_Missense_Mutation_p.I176M	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	223	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)										0.037975	-22.470989	13.99046	6	152	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	47274580	47274580	16133	22	C	G	G	G	382	30	TBC1D22A	3	3
KYNU	8942	broad.mit.edu	37	2	143642955	143642955	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:143642955G>C	uc002tvl.2	+	c.19G>C	c.(19-21)GAG>CAG	p.E7Q	KYNU_uc002tvk.2_Missense_Mutation_p.E7Q|KYNU_uc010fnm.2_Missense_Mutation_p.E7Q	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	7					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)									0.12963	14.285424	21.495648	7	47	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	143642955	143642955	8910	2	G	C	C	C	585	45	KYNU	3	3
TMEFF2	23671	broad.mit.edu	37	2	193059202	193059202	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:193059202C>T	uc002utc.2	-	c.49G>A	c.(49-51)GAG>AAG	p.E17K	TMEFF2_uc002utd.1_Missense_Mutation_p.E17K	NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	17						extracellular region|integral to membrane				pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			Pancreas(50;1277 1381 28487 47072)								0.125	7.220844	13.81379	6	42	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	193059202	193059202	16544	2	C	T	T	T	403	31	TMEFF2	1	1
HECW2	57520	broad.mit.edu	37	2	197106927	197106927	+	Silent	SNP	A	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:197106927A>G	uc002utm.1	-	c.3531T>C	c.(3529-3531)GGT>GGC	p.G1177G	HECW2_uc002utl.1_Silent_p.G821G	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1177					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			ovary(5)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	9														0.184932	66.654561	80.231769	27	119	KEEP	---	---	---	---	capture		Silent	SNP	197106927	197106927	7326	2	A	G	G	G	171	14	HECW2	4	4
CCDC150	284992	broad.mit.edu	37	2	197531497	197531497	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:197531497C>G	uc002utp.1	+	c.817C>G	c.(817-819)CAA>GAA	p.Q273E	CCDC150_uc002uto.1_Missense_Mutation_p.Q273E|CCDC150_uc010zgq.1_Intron|CCDC150_uc010zgr.1_Intron|CCDC150_uc010zgs.1_Intron	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	273	Potential.										0														0.222222	17.834961	19.751663	6	21	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	197531497	197531497	2905	2	C	G	G	G	377	29	CCDC150	3	3
SDC1	6382	broad.mit.edu	37	2	20403660	20403660	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:20403660C>G	uc002rdo.1	-	c.541G>C	c.(541-543)GAG>CAG	p.E181Q	SDC1_uc002rdp.1_Missense_Mutation_p.E181Q|SDC1_uc010exv.2_Intron	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	181	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)										0.193798	67.20563	78.486257	25	104	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20403660	20403660	14436	2	C	G	G	G	416	32	SDC1	3	3
ABCA12	26154	broad.mit.edu	37	2	215851396	215851396	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:215851396C>T	uc002vew.2	-	c.4033G>A	c.(4033-4035)GGG>AGG	p.G1345R	ABCA12_uc002vev.2_Missense_Mutation_p.G1027R|ABCA12_uc010zjn.1_Missense_Mutation_p.G272R	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1345					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|breast(1)|central_nervous_system(1)|pancreas(1)	9		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		Ovarian(66;664 1488 5121 34295)								0.052632	-6.863806	9.206106	4	72	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	215851396	215851396	31	2	C	T	T	T	299	23	ABCA12	1	1
DNAJB2	3300	broad.mit.edu	37	2	220147600	220147600	+	Nonsense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:220147600C>T	uc002vkx.1	+	c.394C>T	c.(394-396)CGA>TGA	p.R132*	DNAJB2_uc002vkw.1_Nonsense_Mutation_p.R132*|DNAJB2_uc002vky.2_5'UTR|DNAJB2_uc010zlb.1_5'UTR	NM_006736	NP_006727	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	132					ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding				0		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)										0.081395	2.726749	33.412755	14	158	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	220147600	220147600	4803	2	C	T	T	T	295	23	DNAJB2	5	1
ABHD1	84696	broad.mit.edu	37	2	27352658	27352658	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:27352658G>C	uc002rit.2	+	c.654G>C	c.(652-654)CAG>CAC	p.Q218H	ABHD1_uc002riu.2_Non-coding_Transcript|ABHD1_uc002riv.2_Non-coding_Transcript	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	218						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)													0.181102	45.610711	57.811444	23	104	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	27352658	27352658	74	2	G	C	C	C	451	35	ABHD1	3	3
SNRNP200	23020	broad.mit.edu	37	2	96956196	96956196	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:96956196G>A	uc002svu.2	-	c.2610C>T	c.(2608-2610)ATC>ATT	p.I870I	SNRNP200_uc002svw.1_5'Flank	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	870	Helicase C-terminal 1.				cis assembly of pre-catalytic spliceosome|response to stimulus|visual perception	catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|large_intestine(1)|skin(1)	7														0.074866	-4.201734	30.485717	14	173	KEEP	---	---	---	---	capture		Silent	SNP	96956196	96956196	15352	2	G	A	A	A	577	45	SNRNP200	2	2
SNRNP200	23020	broad.mit.edu	37	2	96956427	96956427	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:96956427G>A	uc002svu.2	-	c.2548C>T	c.(2548-2550)CTG>TTG	p.L850L	SNRNP200_uc002svw.1_5'Flank	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	850	Helicase C-terminal 1.				cis assembly of pre-catalytic spliceosome|response to stimulus|visual perception	catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|large_intestine(1)|skin(1)	7														0.072386	-10.001544	60.243754	27	346	KEEP	---	---	---	---	capture		Silent	SNP	96956427	96956427	15352	2	G	A	A	A	425	33	SNRNP200	2	2
KIAA2018	205717	broad.mit.edu	37	3	113378190	113378190	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:113378190G>A	uc003eam.2	-	c.2339C>T	c.(2338-2340)TCA>TTA	p.S780L	KIAA2018_uc003eal.2_Missense_Mutation_p.S724L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	780						membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|transcription regulator activity			ovary(1)	1														0.07947	-2.22446	25.042451	12	139	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	113378190	113378190	8579	3	G	A	A	A	585	45	KIAA2018	2	2
ATR	545	broad.mit.edu	37	3	142255000	142255000	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:142255000C>G	uc003eux.3	-	c.3769G>C	c.(3769-3771)GAT>CAT	p.D1257H		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1257					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|breast(4)|ovary(3)|skin(2)|stomach(1)|central_nervous_system(1)|liver(1)	17										936				0.093023	10.03028	24.359212	8	78	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	142255000	142255000	1223	3	C	G	G	G	377	29	ATR	3	3
SERPINI1	5274	broad.mit.edu	37	3	167510457	167510457	+	Missense_Mutation	SNP	G	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:167510457G>T	uc003ffa.3	+	c.561G>T	c.(559-561)AAG>AAT	p.K187N	SERPINI1_uc003ffb.3_Missense_Mutation_p.K187N	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	187					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1														0.057143	-8.742474	12.880678	6	99	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	167510457	167510457	14606	3	G	T	T	T	451	35	SERPINI1	2	2
ARPM1	84517	broad.mit.edu	37	3	169485492	169485492	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:169485492C>T	uc003ffs.1	-	c.847G>A	c.(847-849)GAT>AAT	p.D283N	TERC_uc003ffr.1_5'Flank	NM_032487	NP_115876	Q9BYD9	ARPM1_HUMAN	actin related protein M1	283						cytoplasm|cytoskeleton					0	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;5.01e-59)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)											0.057034	-24.210356	29.995998	15	248	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	169485492	169485492	994	3	C	T	T	T	377	29	ARPM1	2	2
LRCH3	84859	broad.mit.edu	37	3	197581296	197581296	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:197581296G>A	uc011bul.1	+	c.1624G>A	c.(1624-1626)GAT>AAT	p.D542N	LRCH3_uc003fyj.1_Missense_Mutation_p.D542N|LRCH3_uc011bum.1_Missense_Mutation_p.D514N|LRCH3_uc011bun.1_Missense_Mutation_p.D388N|LRCH3_uc003fyk.2_Missense_Mutation_p.D137N	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	542						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)										0.166667	34.143098	46.165013	19	95	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	197581296	197581296	9307	3	G	A	A	A	585	45	LRCH3	2	2
DLEC1	9940	broad.mit.edu	37	3	38151719	38151719	+	Silent	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:38151719C>G	uc003chp.1	+	c.3390C>G	c.(3388-3390)CTC>CTG	p.L1130L	DLEC1_uc003cho.1_Silent_p.L1130L|DLEC1_uc010hgv.1_Silent_p.L1133L|DLEC1_uc003chr.1_Silent_p.L236L|DLEC1_uc010hgx.1_Non-coding_Transcript	NM_007337	NP_031363	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	1130					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|breast(1)|skin(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)										0.078125	8.566982	43.498851	15	177	KEEP	---	---	---	---	capture		Silent	SNP	38151719	38151719	4732	3	C	G	G	G	366	29	DLEC1	3	3
CACNA1D	776	broad.mit.edu	37	3	53785859	53785859	+	Nonsense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:53785859C>G	uc003dgu.3	+	c.3660C>G	c.(3658-3660)TAC>TAG	p.Y1220*	CACNA1D_uc003dgv.3_Nonsense_Mutation_p.Y1200*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.Y1200*|CACNA1D_uc003dgw.3_Nonsense_Mutation_p.Y867*|CACNA1D_uc003dgx.1_Nonsense_Mutation_p.Y348*	NM_000720	NP_000711	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1200	IV.|Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|liver(1)	7				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)									0.082067	14.506247	73.234004	27	302	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	53785859	53785859	2657	3	C	G	G	G	246	19	CACNA1D	5	3
BANK1	55024	broad.mit.edu	37	4	102839186	102839186	+	Missense_Mutation	SNP	G	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:102839186G>T	uc003hvy.3	+	c.1046G>T	c.(1045-1047)TGT>TTT	p.C349F	BANK1_uc003hvx.3_Missense_Mutation_p.C334F|BANK1_uc010ill.2_Missense_Mutation_p.C216F|BANK1_uc003hvz.3_Missense_Mutation_p.C319F	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	349	ANK 1.				B cell activation					ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)										0.261905	61.208623	65.518928	22	62	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	102839186	102839186	1330	4	G	T	T	T	624	48	BANK1	2	2
ANKRD50	57182	broad.mit.edu	37	4	125591892	125591892	+	Missense_Mutation	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:125591892C>A	uc003ifg.3	-	c.2540G>T	c.(2539-2541)GGA>GTA	p.G847V	ANKRD50_uc011cgo.1_Missense_Mutation_p.G668V|ANKRD50_uc010inw.2_Missense_Mutation_p.G847V	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	847	ANK 12.									central_nervous_system(1)	1														0.055838	-19.747962	21.141814	11	186	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	125591892	125591892	685	4	C	A	A	A	390	30	ANKRD50	2	2
ATP8A1	10396	broad.mit.edu	37	4	42457409	42457409	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:42457409G>C	uc003gwr.2	-	c.2722C>G	c.(2722-2724)CTT>GTT	p.L908V	ATP8A1_uc003gwq.2_Missense_Mutation_p.L134V|ATP8A1_uc003gws.2_Missense_Mutation_p.L893V	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	908	Helical; (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(1)	1					Phosphatidylserine(DB00144)									0.057692	-6.436592	14.925628	6	98	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	42457409	42457409	1211	4	G	C	C	C	429	33	ATP8A1	3	3
TMPRSS11A	339967	broad.mit.edu	37	4	68812269	68812269	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:68812269C>T	uc003hdr.1	-	c.32G>A	c.(31-33)CGA>CAA	p.R11Q	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.R11Q	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	11	Cytoplasmic (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity				0						NSCLC(26;2 894 10941 14480 22546)								0.083333	1.427904	12.013986	5	55	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	68812269	68812269	16779	4	C	T	T	T	403	31	TMPRSS11A	1	1
SLCO4C1	353189	broad.mit.edu	37	5	101595922	101595922	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:101595922G>C	uc003knm.2	-	c.1123C>G	c.(1123-1125)CTA>GTA	p.L375V		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	375	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)										0.166667	5.812187	7.710327	3	15	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	101595922	101595922	15227	5	G	C	C	C	425	33	SLCO4C1	3	3
SLCO6A1	133482	broad.mit.edu	37	5	101755593	101755593	+	Missense_Mutation	SNP	A	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:101755593A>T	uc003knn.2	-	c.1409T>A	c.(1408-1410)GTG>GAG	p.V470E	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Missense_Mutation_p.V470E|SLCO6A1_uc003knq.2_Missense_Mutation_p.V408E	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	470	Helical; Name=9; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|central_nervous_system(1)	4		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)										0.160494	24.422224	33.311349	13	68	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	101755593	101755593	15229	5	A	T	T	T	78	6	SLCO6A1	3	3
CD14	929	broad.mit.edu	37	5	140012043	140012043	+	Missense_Mutation	SNP	T	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140012043T>G	uc003lgi.1	-	c.526A>C	c.(526-528)AGC>CGC	p.S176R	CD14_uc003lgj.1_Missense_Mutation_p.S176R	NM_000591	NP_000582	P08571	CD14_HUMAN	CD14 antigen precursor	176	LRR 5.				apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.15625	19.109486	26.329685	10	54	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	140012043	140012043	3091	5	T	G	G	G	702	54	CD14	4	4
TMCO6	55374	broad.mit.edu	37	5	140022504	140022504	+	Silent	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140022504C>G	uc003lgm.2	+	c.702C>G	c.(700-702)GCC>GCG	p.A234A	TMCO6_uc003lgl.2_Intron|TMCO6_uc010jft.2_Intron|TMCO6_uc003lgn.2_Intron|TMCO6_uc003lgo.2_5'UTR	NM_018502	NP_060972	Q96DC7	TMCO6_HUMAN	transmembrane and coiled-coil domains 6	230					protein import into nucleus	cytoplasm|nuclear pore	binding|protein transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.086957	4.158641	24.022645	10	105	KEEP	---	---	---	---	capture		Silent	SNP	140022504	140022504	16530	5	C	G	G	G	261	21	TMCO6	3	3
PCDHGC5	56097	broad.mit.edu	37	5	140890710	140890710	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140890710G>C	uc003lla.1	+	c.2805G>C	c.(2803-2805)AAG>AAC	p.K935N	PCDHGA1_uc003lji.1_Missense_Mutation_p.K922N|PCDHGA2_uc003ljk.1_Missense_Mutation_p.K923N|PCDHGA3_uc003ljm.1_Missense_Mutation_p.K923N|PCDHGA3_uc010jfx.1_Missense_Mutation_p.K683N|PCDHGB1_uc003ljo.1_Missense_Mutation_p.K918N|PCDHGA4_uc003ljq.1_Missense_Mutation_p.K922N|PCDHGB2_uc003ljs.1_Missense_Mutation_p.K922N|PCDHGA5_uc003lju.1_Missense_Mutation_p.K922N|PCDHGB3_uc003ljw.1_Missense_Mutation_p.K920N|PCDHGA6_uc003ljy.1_Missense_Mutation_p.K923N|PCDHGA7_uc003lka.1_Missense_Mutation_p.K923N|PCDHGB4_uc003lkc.1_Missense_Mutation_p.K914N|PCDHGA8_uc003lkd.1_Missense_Mutation_p.K923N|PCDHGB5_uc003lkf.1_Missense_Mutation_p.K914N|PCDHGA9_uc003lkh.1_Missense_Mutation_p.K923N|PCDHGB6_uc003lkj.1_Missense_Mutation_p.K921N|PCDHGA10_uc003lkl.1_Missense_Mutation_p.K927N|PCDHGB7_uc003lkn.1_Missense_Mutation_p.K920N|PCDHGA11_uc003lkp.1_Missense_Mutation_p.K741N|PCDHGA11_uc003lkq.1_Missense_Mutation_p.K926N|PCDHGA12_uc003lkt.1_Missense_Mutation_p.K923N|PCDHGC3_uc003lkv.1_Missense_Mutation_p.K925N|PCDHGC3_uc003lkw.1_Missense_Mutation_p.K125N|PCDHGC4_uc003lky.1_Missense_Mutation_p.K929N	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	935	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.07619	4.312469	23.635256	8	97	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	140890710	140890710	11991	5	G	C	C	C	425	33	PCDHGC5	3	3
MYO10	4651	broad.mit.edu	37	5	16701570	16701570	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:16701570C>T	uc003jft.3	-	c.2934G>A	c.(2932-2934)GAG>GAA	p.E978E	MYO10_uc011cnc.1_5'Flank|MYO10_uc011cnd.1_Silent_p.E335E|MYO10_uc011cne.1_Silent_p.E335E|MYO10_uc010itx.2_Silent_p.E601E	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	978					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3														0.108696	5.641269	12.619694	5	41	KEEP	---	---	---	---	capture		Silent	SNP	16701570	16701570	10457	5	C	T	T	T	415	32	MYO10	2	2
HMP19	51617	broad.mit.edu	37	5	173531304	173531304	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:173531304C>G	uc003mcx.2	+	c.287C>G	c.(286-288)ACC>AGC	p.T96S	HMP19_uc011dfh.1_5'UTR	NM_015980	NP_057064	Q9Y328	NSG2_HUMAN	HMP19 protein	96	Lumenal (Potential).				dopamine receptor signaling pathway	cytoplasmic vesicle membrane|Golgi cisterna membrane|integral to membrane|multivesicular body membrane	dopamine receptor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00925)|all_lung(126;0.0148)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)											0.172414	38.278541	47.091315	15	72	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	173531304	173531304	7537	5	C	G	G	G	234	18	HMP19	3	3
GPRIN1	114787	broad.mit.edu	37	5	176026184	176026184	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:176026184C>G	uc003meo.1	-	c.652G>C	c.(652-654)GAT>CAT	p.D218H		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	218						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)											0.078534	6.367247	41.035859	15	176	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	176026184	176026184	7005	5	C	G	G	G	416	32	GPRIN1	3	3
ZFP2	80108	broad.mit.edu	37	5	178359365	178359365	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:178359365G>A	uc003mjn.1	+	c.1051G>A	c.(1051-1053)GAG>AAG	p.E351K	ZFP2_uc010jky.2_Missense_Mutation_p.E351K|ZFP2_uc010jkx.1_Missense_Mutation_p.E351K	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)										0.074468	-1.053916	16.42485	7	87	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	178359365	178359365	18229	5	G	A	A	A	429	33	ZFP2	2	2
SDHA	6389	broad.mit.edu	37	5	251536	251536	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:251536G>C	uc011clv.1	+	c.1747G>C	c.(1747-1749)GAG>CAG	p.E583Q	SDHA_uc003jao.3_Missense_Mutation_p.E583Q|SDHA_uc011clw.1_Missense_Mutation_p.E535Q|SDHA_uc003jap.3_Intron|SDHA_uc003jaq.3_Missense_Mutation_p.E358Q|SDHA_uc003jar.3_Missense_Mutation_p.E177Q	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	583					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)									0.04186	-26.315712	22.170932	9	206	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	251536	251536	14448	5	G	C	C	C	429	33	SDHA	3	3
CDH6	1004	broad.mit.edu	37	5	31317488	31317488	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:31317488C>G	uc003jhe.1	+	c.1519C>G	c.(1519-1521)CAG>GAG	p.Q507E	CDH6_uc003jhd.1_Missense_Mutation_p.Q507E	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	507	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|large_intestine(1)	5														0.09375	8.899175	24.826151	9	87	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	31317488	31317488	3243	5	C	G	G	G	377	29	CDH6	3	3
PLK2	10769	broad.mit.edu	37	5	57753340	57753340	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:57753340C>T	uc003jrn.2	-	c.784G>A	c.(784-786)GAC>AAC	p.D262N		NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	262	Protein kinase.				positive regulation of I-kappaB kinase/NF-kappaB cascade|protein phosphorylation		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)	3		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)						266				0.108108	9.04202	20.311096	8	66	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57753340	57753340	12522	5	C	T	T	T	416	32	PLK2	2	2
ERBB2IP	55914	broad.mit.edu	37	5	65288649	65288649	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:65288649G>C	uc011cqx.1	+	c.103G>C	c.(103-105)GAA>CAA	p.E35Q	ERBB2IP_uc003juh.1_Missense_Mutation_p.E35Q|ERBB2IP_uc003jui.1_Missense_Mutation_p.E35Q|ERBB2IP_uc003juj.1_Missense_Mutation_p.E35Q|ERBB2IP_uc003juk.1_Missense_Mutation_p.E35Q|ERBB2IP_uc011cqy.1_Missense_Mutation_p.E35Q|ERBB2IP_uc011cqz.1_Missense_Mutation_p.E35Q|ERBB2IP_uc010iwx.1_Missense_Mutation_p.E35Q|ERBB2IP_uc003jul.1_Missense_Mutation_p.E35Q	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	35	LRR 1.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(1)	6		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)										0.041096	-17.182836	15.897643	6	140	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	65288649	65288649	5400	5	G	C	C	C	429	33	ERBB2IP	3	3
MAST4	375449	broad.mit.edu	37	5	66460707	66460707	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:66460707G>A	uc003jut.1	+	c.5133G>A	c.(5131-5133)AGG>AGA	p.R1711R	MAST4_uc003juw.2_Silent_p.R1639R|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1903					protein phosphorylation	cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)						805				0.08	0.40018	13.887331	6	69	KEEP	---	---	---	---	capture		Silent	SNP	66460707	66460707	9711	5	G	A	A	A	529	41	MAST4	2	2
CD180	4064	broad.mit.edu	37	5	66480332	66480332	+	Silent	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:66480332C>G	uc003juy.2	-	c.339G>C	c.(337-339)CTG>CTC	p.L113L		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	113	LRR 3.|Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)										0.090909	16.086136	49.498599	18	180	KEEP	---	---	---	---	capture		Silent	SNP	66480332	66480332	3099	5	C	G	G	G	366	29	CD180	3	3
ENC1	8507	broad.mit.edu	37	5	73931322	73931322	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:73931322C>G	uc003kdc.3	-	c.989G>C	c.(988-990)AGA>ACA	p.R330T	ENC1_uc011css.1_Missense_Mutation_p.R257T	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	330	Kelch 1.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)										0.041152	-30.94422	24.074349	10	233	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	73931322	73931322	5306	5	C	G	G	G	416	32	ENC1	3	3
F2R	2149	broad.mit.edu	37	5	76028674	76028674	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:76028674G>A	uc003ken.3	+	c.624G>A	c.(622-624)ATG>ATA	p.M208I		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	208	Cytoplasmic (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|platelet dense granule organization|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)									0.132616	42.668931	79.315519	37	242	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	76028674	76028674	5537	5	G	A	A	A	598	46	F2R	2	2
PAK1IP1	55003	broad.mit.edu	37	6	10707679	10707679	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:10707679G>C	uc003mzg.2	+	c.772G>C	c.(772-774)GAG>CAG	p.E258Q		NM_017906	NP_060376	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	258	WD 5.				negative regulation of signal transduction	nucleolus|plasma membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)												0.046414	-24.592627	27.423814	11	226	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10707679	10707679	11816	6	G	C	C	C	429	33	PAK1IP1	3	3
KHDRBS2	202559	broad.mit.edu	37	6	62688017	62688017	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:62688017G>A	uc003peg.2	-	c.437C>T	c.(436-438)TCA>TTA	p.S146L		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(3)|liver(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(397;0.149)										0.105263	7.772778	22.495377	10	85	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	62688017	62688017	8453	6	G	A	A	A	585	45	KHDRBS2	2	2
MUC17	140453	broad.mit.edu	37	7	100682517	100682517	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:100682517C>T	uc003uxp.1	+	c.7820C>T	c.(7819-7821)ACT>ATT	p.T2607I	MUC17_uc010lho.1_Non-coding_Transcript	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2607	Extracellular (Potential).|59 X approximate tandem repeats.|42.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|breast(3)|lung(2)	19	Lung NSC(181;0.136)|all_lung(186;0.182)													0.154812	144.660511	199.063623	74	404	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100682517	100682517	10368	7	C	T	T	T	260	20	MUC17	2	2
CLDN15	24146	broad.mit.edu	37	7	100877591	100877591	+	Missense_Mutation	SNP	G	A	A	rs80277788		TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:100877591G>A	uc003uyg.1	-	c.350C>T	c.(349-351)GCG>GTG	p.A117V	CLDN15_uc003uyh.1_Missense_Mutation_p.A117V|CLDN15_uc003uyi.2_3'UTR	NM_014343	NP_055158	P56746	CLD15_HUMAN	claudin 15	117	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)													0.294872	109.996085	115.868727	46	110	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100877591	100877591	3612	7	G	A	A	A	494	38	CLDN15	1	1
RNF133	168433	broad.mit.edu	37	7	122338652	122338653	+	Missense_Mutation	DNP	CC	AG	AG			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:122338652_122338653CC>AG	uc003vkj.1	-	c.320_321GG>CT	c.(319-321)CGG>CCT	p.R107P	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	107	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding				0						Colon(198;1778 2057 7449 19869 45985)								0.081784	3.273717	51.145464	22	247	KEEP	---	---	---	---	capture		Missense_Mutation	DNP	122338652	122338653	13916	7	CC	AG	AG	AG	275	22	RNF133	2	2
MEST	4232	broad.mit.edu	37	7	130143804	130143804	+	Missense_Mutation	SNP	T	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:130143804T>G	uc003vqg.2	+	c.857T>G	c.(856-858)GTA>GGA	p.V286G	MEST_uc003vqc.2_Missense_Mutation_p.V277G|MEST_uc003vqd.2_Missense_Mutation_p.V243G|MEST_uc003vqf.2_Missense_Mutation_p.V277G|MEST_uc011kph.1_Missense_Mutation_p.V272G|MEST_uc010lmg.2_Intron	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	286	Helical; (Potential).				mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)					Colon(126;2182 2305 6517 35181)								0.073298	0.895821	36.677787	14	177	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	130143804	130143804	9873	7	T	G	G	G	741	57	MEST	4	4
CNOT4	4850	broad.mit.edu	37	7	135098287	135098287	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:135098287G>A	uc011kpy.1	-	c.637C>T	c.(637-639)CTT>TTT	p.L213F	CNOT4_uc003vss.2_Missense_Mutation_p.L213F|CNOT4_uc011kpz.1_Missense_Mutation_p.L213F|CNOT4_uc003vst.2_Missense_Mutation_p.L213F|CNOT4_uc003vsu.1_Missense_Mutation_p.L213F|CNOT4_uc003vsv.1_Missense_Mutation_p.L213F	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	213	C3H1-type.				nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						Ovarian(51;766 1130 5502 35047 50875)								0.058824	-5.597937	11.730265	5	80	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	135098287	135098287	3759	7	G	A	A	A	429	33	CNOT4	2	2
KIAA1549	57670	broad.mit.edu	37	7	138602619	138602619	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:138602619C>G	uc011kql.1	-	c.1753G>C	c.(1753-1755)GAC>CAC	p.D585H	KIAA1549_uc003vuk.3_Missense_Mutation_p.D535H|KIAA1549_uc011kqj.1_Missense_Mutation_p.D585H	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	585	Ser-rich.					integral to membrane			KIAA1549/BRAF(211)	central_nervous_system(211)|pancreas(1)	212						NSCLC(119;1534 1718 44213 46230 50068)				967				0.137931	8.679262	12.356088	4	25	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	138602619	138602619	8553	7	C	G	G	G	416	32	KIAA1549	3	3
CLCN1	1180	broad.mit.edu	37	7	143027907	143027907	+	Missense_Mutation	SNP	T	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:143027907T>G	uc003wcr.1	+	c.896T>G	c.(895-897)GTT>GGT	p.V299G	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_Non-coding_Transcript|CLCN1_uc010lox.1_Non-coding_Transcript|CLCN1_uc010loy.1_Missense_Mutation_p.F95V	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	299					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)|breast(1)|central_nervous_system(1)	3	Melanoma(164;0.205)													0.338983	136.206225	138.939607	40	78	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	143027907	143027907	3598	7	T	G	G	G	780	60	CLCN1	4	4
MAD1L1	8379	broad.mit.edu	37	7	2108903	2108903	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:2108903C>T	uc003slh.1	-	c.1144G>A	c.(1144-1146)GAG>AAG	p.E382K	MAD1L1_uc003sle.1_Missense_Mutation_p.E111K|MAD1L1_uc003slf.1_Missense_Mutation_p.E382K|MAD1L1_uc003slg.1_Missense_Mutation_p.E382K|MAD1L1_uc010ksh.1_Missense_Mutation_p.E382K|MAD1L1_uc003sli.1_Missense_Mutation_p.E290K|MAD1L1_uc010ksi.1_Missense_Mutation_p.E335K|MAD1L1_uc010ksj.2_Missense_Mutation_p.E382K	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	382	Necessary for interaction with NEK2.|Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)										0.055556	-11.430897	11.017507	6	102	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	2108903	2108903	9524	7	C	T	T	T	390	30	MAD1L1	2	2
HECW1	23072	broad.mit.edu	37	7	43548608	43548608	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:43548608C>T	uc003tid.1	+	c.3907C>T	c.(3907-3909)CTG>TTG	p.L1303L	HECW1_uc011kbi.1_Silent_p.L1269L	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1303	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(7)|breast(2)|skin(2)|pancreas(1)|lung(1)	13										944				0.049536	-36.591421	33.003854	16	307	KEEP	---	---	---	---	capture		Silent	SNP	43548608	43548608	7325	7	C	T	T	T	415	32	HECW1	2	2
ACN9	57001	broad.mit.edu	37	7	96810322	96810322	+	Splice_Site_SNP	SNP	A	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:96810322A>G	uc003uoo.3	+	c.175_splice	c.e2-2	p.V59_splice		NM_020186	NP_064571			ACN9 homolog precursor						regulation of gluconeogenesis	mitochondrial intermembrane space					0	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)													0.138889	11.652455	16.186797	5	31	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	96810322	96810322	146	7	A	G	G	G	195	15	ACN9	5	4
UBR5	51366	broad.mit.edu	37	8	103291157	103291157	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:103291157C>G	uc003ykr.1	-	c.6185G>C	c.(6184-6186)AGA>ACA	p.R2062T	UBR5_uc003yks.1_Missense_Mutation_p.R2062T	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2062					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(5)|ovary(3)|large_intestine(3)|kidney(1)|central_nervous_system(1)	13	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			Ovarian(131;96 1741 5634 7352 27489)				1024				0.055556	-15.322662	33.30391	13	221	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	103291157	103291157	17463	8	C	G	G	G	416	32	UBR5	3	3
CSMD3	114788	broad.mit.edu	37	8	113694818	113694818	+	Missense_Mutation	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:113694818G>A	uc003ynu.2	-	c.2530C>T	c.(2530-2532)CGG>TGG	p.R844W	CSMD3_uc003yns.2_Missense_Mutation_p.R116W|CSMD3_uc003ynt.2_Missense_Mutation_p.R804W|CSMD3_uc011lhx.1_Missense_Mutation_p.R740W	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	844	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(20)|lung(11)|kidney(8)|large_intestine(6)|skin(3)|central_nervous_system(2)|urinary_tract(1)|breast(1)	52										2888	TCGA Ovarian(7;0.080)			0.116959	23.370772	48.057926	20	151	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	113694818	113694818	4087	8	G	A	A	A	519	40	CSMD3	1	1
DEPDC6	64798	broad.mit.edu	37	8	121019082	121019082	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:121019082C>T	uc003yow.3	+	c.964C>T	c.(964-966)CCC>TCC	p.P322S	DEPDC6_uc011lid.1_Missense_Mutation_p.P221S	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	322					intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)											0.05	-9.172622	8.016838	4	76	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	121019082	121019082	4622	8	C	T	T	T	390	30	DEPDC6	2	2
WDR67	93594	broad.mit.edu	37	8	124089411	124089411	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:124089411G>C	uc003ypp.1	+	c.138G>C	c.(136-138)TTG>TTC	p.L46F	WDR67_uc011lig.1_Missense_Mutation_p.L46F|WDR67_uc011lih.1_5'UTR|WDR67_uc003ypq.1_Non-coding_Transcript|WDR67_uc003ypo.1_Missense_Mutation_p.L46F	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	46	WD 1.					intracellular	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)											0.072464	1.364147	53.292267	20	256	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	124089411	124089411	17891	8	G	C	C	C	581	45	WDR67	3	3
PYCRL	65263	broad.mit.edu	37	8	144689207	144689207	+	Silent	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:144689207G>C	uc003yyy.2	-	c.288C>G	c.(286-288)GTC>GTG	p.V96V	PYCRL_uc011lkm.1_Silent_p.V96V|PYCRL_uc011lkn.1_Non-coding_Transcript	NM_023078	NP_075566	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	84					oxidation-reduction process|proline biosynthetic process		pyrroline-5-carboxylate reductase activity				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)											0.088235	8.591737	26.079307	9	93	KEEP	---	---	---	---	capture		Silent	SNP	144689207	144689207	13315	8	G	C	C	C	522	41	PYCRL	3	3
PTK2B	2185	broad.mit.edu	37	8	27287917	27287917	+	Silent	SNP	G	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:27287917G>A	uc003xfn.1	+	c.651G>A	c.(649-651)CAG>CAA	p.Q217Q	PTK2B_uc003xfo.1_Silent_p.Q217Q|PTK2B_uc003xfp.1_Silent_p.Q217Q|PTK2B_uc003xfq.1_Silent_p.Q217Q|PTK2B_uc010luq.1_5'Flank|PTK2B_uc003xfr.1_5'Flank	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	217	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			ovary(1)|skin(1)	2		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)						347				0.102362	14.67432	34.691291	13	114	KEEP	---	---	---	---	capture		Silent	SNP	27287917	27287917	13218	8	G	A	A	A	425	33	PTK2B	2	2
TTPA	7274	broad.mit.edu	37	8	63978592	63978592	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:63978592C>G	uc003xux.1	-	c.423G>C	c.(421-423)GAG>GAC	p.E141D		NM_000370	NP_000361	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	141	CRAL-TRIO.		E -> K (in AVED).		lipid metabolic process		transporter activity|vitamin E binding				0	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)									0.4375	98.892488	99.110238	28	36	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	63978592	63978592	17291	8	C	G	G	G	363	28	TTPA	3	3
TDRD7	23424	broad.mit.edu	37	9	100258036	100258036	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:100258036C>T	uc004axj.2	+	c.3168C>T	c.(3166-3168)GTC>GTT	p.V1056V	TDRD7_uc011lux.1_Silent_p.V982V|TDRD7_uc011luy.1_Silent_p.V376V	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	1056	Interacts with CDK17 (By similarity).|Interacts with CABLES1 (By similarity).				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)												0.129944	29.391666	52.99311	23	154	KEEP	---	---	---	---	capture		Silent	SNP	100258036	100258036	16262	9	C	T	T	T	366	29	TDRD7	2	2
GPRASP1	9737	broad.mit.edu	37	X	101909157	101909157	+	Missense_Mutation	SNP	T	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:101909157T>A	uc004ejj.3	+	c.316T>A	c.(316-318)TCT>ACT	p.S106T	GPRASP1_uc004eji.3_Missense_Mutation_p.S106T|GPRASP1_uc010nod.2_Missense_Mutation_p.S106T	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	106						cytoplasm	protein binding			ovary(1)|lung(1)	2														0.271318	267.02432	285.264473	105	282	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	101909157	101909157	6998	23	T	A	A	A	754	58	GPRASP1	3	3
NUP62CL	54830	broad.mit.edu	37	X	106391025	106391025	+	Missense_Mutation	SNP	G	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:106391025G>T	uc004ena.2	-	c.545C>A	c.(544-546)GCA>GAA	p.A182E	NUP62CL_uc004enb.2_Non-coding_Transcript	NM_017681	NP_060151	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	182					protein transport	nuclear pore	structural constituent of nuclear pore				0														0.25	47.817379	51.90627	18	54	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	106391025	106391025	11174	23	G	T	T	T	598	46	NUP62CL	2	2
CAPN6	827	broad.mit.edu	37	X	110494845	110494845	+	Silent	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:110494845C>T	uc004epc.1	-	c.825G>A	c.(823-825)GAG>GAA	p.E275E	CAPN6_uc011msu.1_Silent_p.E20E	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	275	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6														0.083791	13.910143	142.015171	61	667	KEEP	---	---	---	---	capture		Silent	SNP	110494845	110494845	2748	23	C	T	T	T	415	32	CAPN6	2	2
TLR7	51284	broad.mit.edu	37	X	12905246	12905246	+	Missense_Mutation	SNP	C	A	A			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:12905246C>A	uc004cvc.2	+	c.1619C>A	c.(1618-1620)CCT>CAT	p.P540H		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	540	Extracellular (Potential).|LRR 17.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of inflammatory response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(1)	1					Imiquimod(DB00724)					69				0.288136	413.738721	435.122871	153	378	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	12905246	12905246	16486	23	C	A	A	A	312	24	TLR7	2	2
TLR8	51311	broad.mit.edu	37	X	12937571	12937571	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:12937571C>T	uc004cvd.2	+	c.466C>T	c.(466-468)CCC>TCC	p.P156S	TLR8_uc004cve.2_Missense_Mutation_p.P138S	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	138	LRR 1.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane|integral to membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|large_intestine(1)	5														0.222222	116.043616	132.008783	50	175	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	12937571	12937571	16487	23	C	T	T	T	234	18	TLR8	2	2
TKTL1	8277	broad.mit.edu	37	X	153539356	153539356	+	Missense_Mutation	SNP	C	G	G			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:153539356C>G	uc004fkg.2	+	c.520C>G	c.(520-522)CAG>GAG	p.Q174E	TKTL1_uc011mzl.1_Missense_Mutation_p.Q168E|TKTL1_uc011mzm.1_Intron|TKTL1_uc004fkh.2_Missense_Mutation_p.Q118E	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	174					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)													0.096552	16.032954	39.692901	14	131	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	153539356	153539356	16464	23	C	G	G	G	377	29	TKTL1	3	3
GAB3	139716	broad.mit.edu	37	X	153944516	153944516	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:153944516C>T	uc004fmk.1	-	c.161G>A	c.(160-162)AGC>AAC	p.S54N	GAB3_uc004fmj.1_Missense_Mutation_p.S54N|GAB3_uc010nve.1_Missense_Mutation_p.S54N|GAB3_uc004fml.1_5'UTR	NM_001081573	NP_001075042	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 1	54	PH.									ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)													0.043478	-24.167103	16.935782	8	176	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	153944516	153944516	6401	23	C	T	T	T	364	28	GAB3	2	2
CACNA1F	778	broad.mit.edu	37	X	49068406	49068406	+	Missense_Mutation	SNP	C	T	T			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:49068406C>T	uc004dnb.2	-	c.4085G>A	c.(4084-4086)CGA>CAA	p.R1362Q	CACNA1F_uc010nip.2_Missense_Mutation_p.R1351Q	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1362	Extracellular (Potential).|IV.				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)					279				0.122093	25.773932	49.82191	21	151	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	49068406	49068406	2659	23	C	T	T	T	403	31	CACNA1F	1	1
MAGEE2	139599	broad.mit.edu	37	X	75003459	75003459	+	Missense_Mutation	SNP	G	C	C			TCGA-05-4402-01	TCGA-05-4402-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:75003459G>C	uc004ecj.1	-	c.1428C>G	c.(1426-1428)ATC>ATG	p.I476M		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	476	MAGE 2.									ovary(1)	1														0.084848	11.411854	40.275075	14	151	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	75003459	75003459	9569	23	G	C	C	C	577	45	MAGEE2	3	3
