Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
GJD4	219770	broad.mit.edu	36	10	35936767	35936767	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:35936767G>C	uc001iyy.1	+	c.320G>C	c.(319-321)GGC>GCC	p.G107A		NM_153368	NP_699199	Q96KN9	CXD4_HUMAN	connexin40.1	107	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane				large_intestine(2)|central_nervous_system(1)|pancreas(1)	4														0.318182	6.782205	7.452571	7	15	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	35936767	35936767	6687	10	G	C	C	42	42	GJD4	C	3	3
LIPK	643414	broad.mit.edu	36	10	90487485	90487485	+	Silent	SNP	T	C	C			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr10:90487485T>C	uc001kfi.1	+	c.783T>C	c.(781-783)ACT>ACC	p.T261T		NM_001080518	NP_001073987	Q5VXJ0	LIPK_HUMAN	lipase, family member K	261					lipid catabolic process	extracellular region	hydrolase activity			ovary(2)	2		Colorectal(252;0.0381)												0.47561	271.942947	272.027649	78	86	TT		KEEP	---	---	---	---	capture		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)	Silent	SNP	90487485	90487485	9154	10	T	C	C	54	54	LIPK	C	4	4
MUC5B	727897	broad.mit.edu	36	11	1229397	1229397	+	Missense_Mutation	SNP	G	A	A	rs56353324	unknown	TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:1229397G>A	uc001ltb.2	+	c.14720G>A	c.(14719-14721)CGC>CAC	p.R4907H		NM_002458	NP_002449	Q9HC84	MUC5B_HUMAN	mucin 5, subtype B, tracheobronchial	4904	Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)												0.333333	38.696861	39.810562	15	30	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)	Missense_Mutation	SNP	1229397	1229397	10373	11	G	A	A	38	38	MUC5B	A	1	1
SLC17A6	57084	broad.mit.edu	36	11	22348310	22348310	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:22348310G>C	uc001mqk.1	+	c.1041G>C	c.(1039-1041)AAG>AAC	p.K347N		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	347	Vesicular (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4														0.258929	73.318714	79.217933	29	83	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	22348310	22348310	14917	11	G	C	C	35	35	SLC17A6	C	3	3
OR51D1	390038	broad.mit.edu	36	11	4617999	4617999	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:4617999C>T	uc001lzh.1	+	c.403C>T	c.(403-405)CGC>TGC	p.R135C		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)												0.263473	118.449964	126.882532	44	123	CC		KEEP	---	---	---	---	capture		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)	Missense_Mutation	SNP	4617999	4617999	11503	11	C	T	T	23	23	OR51D1	T	1	1
CCDC88B	283234	broad.mit.edu	36	11	63878118	63878118	+	Silent	SNP	T	G	G			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:63878118T>G	uc001nzy.1	+	c.3999T>G	c.(3997-3999)CCT>CCG	p.P1333P	CCDC88B_uc009ypo.1_Silent_p.P1330P|CCDC88B_uc001oaa.1_Intron|CCDC88B_uc001oab.1_Silent_p.P164P|CCDC88B_uc001oac.1_Intron	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1333					microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)	3														0.388889	8.536807	8.785839	7	11	TT		KEEP	---	---	---	---	capture			Silent	SNP	63878118	63878118	2989	11	T	G	G	55	55	CCDC88B	G	4	4
RBMXL2	27288	broad.mit.edu	36	11	7067121	7067121	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:7067121C>T	uc001mfc.2	+	c.194C>T	c.(193-195)GCC>GTC	p.A65V		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	65	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0														0.269231	16.71151	17.962527	7	19	CC		KEEP	---	---	---	---	capture		Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Missense_Mutation	SNP	7067121	7067121	13616	11	C	T	T	26	26	RBMXL2	T	2	2
GLT8D2	83468	broad.mit.edu	36	12	102914711	102914711	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:102914711C>T	uc001tkh.1	-	c.532G>A	c.(532-534)GCG>ACG	p.A178T	GLT8D2_uc001tki.1_Missense_Mutation_p.A178T	NM_031302	NP_112592	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	178	Lumenal (Potential).					integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)	1														0.273973	104.841846	111.558336	40	106	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	102914711	102914711	6738	12	C	T	T	27	27	GLT8D2	T	1	1
ACACB	32	broad.mit.edu	36	12	108181236	108181236	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:108181236C>T	uc001tob.1	+	c.6436C>T	c.(6436-6438)CGG>TGG	p.R2146W	ACACB_uc001toc.1_Missense_Mutation_p.R2146W|ACACB_uc001tod.1_Non-coding_Transcript	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2146	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|pancreas(1)	6					Biotin(DB00121)					1843				0.255875	256.676026	277.373927	98	285	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	108181236	108181236	108	12	C	T	T	23	23	ACACB	T	1	1
ACAD10	80724	broad.mit.edu	36	12	110667025	110667025	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:110667025G>C	uc009zvx.1	+	c.2003G>C	c.(2002-2004)AGC>ACC	p.S668T	ACAD10_uc001tsp.1_Missense_Mutation_p.S637T|ACAD10_uc001tsq.1_Missense_Mutation_p.S637T|ACAD10_uc001tss.1_Non-coding_Transcript	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	637					oxidation-reduction process		acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity			ovary(2)	2														0.35	128.398874	130.787431	42	78	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	110667025	110667025	109	12	G	C	C	34	34	ACAD10	C	3	3
KCNJ8	3764	broad.mit.edu	36	12	21809994	21809994	+	Missense_Mutation	SNP	T	C	C			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr12:21809994T>C	uc001rff.1	-	c.1205A>G	c.(1204-1206)AAT>AGT	p.N402S		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	402	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)									0.319066	250.866439	258.339211	82	175	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	21809994	21809994	8361	12	T	C	C	52	52	KCNJ8	C	4	4
NTN4	59277	broad.mit.edu	36	12	94577103	94577103	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:94577103C>T	uc001tei.1	-	c.1777G>A	c.(1777-1779)GAG>AAG	p.E593K	NTN4_uc009ztf.1_Missense_Mutation_p.E570K|NTN4_uc009ztg.1_Missense_Mutation_p.E556K	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4	593	NTR.				axon guidance	basement membrane|plasma membrane				ovary(1)	1														0.297521	93.245896	97.685277	36	85	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	94577103	94577103	11107	12	C	T	T	29	29	NTN4	T	2	2
IRS2	8660	broad.mit.edu	36	13	109232607	109232607	+	Silent	SNP	T	G	G			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr13:109232607T>G	uc001vqv.1	-	c.3795A>C	c.(3793-3795)CCA>CCC	p.P1265P		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1265	Poly-Pro.				fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	5	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)				Melanoma(100;613 2409 40847)				156				0.6	7.112401	7.154273	3	2	TT		KEEP	---	---	---	---	capture	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)		Silent	SNP	109232607	109232607	8145	13	T	G	G	59	59	IRS2	G	4	4
NUFIP1	26747	broad.mit.edu	36	13	44452922	44452922	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr13:44452922C>T	uc001uzp.2	-	c.529G>A	c.(529-531)GAT>AAT	p.D177N		NM_012345	NP_036477	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein	177	C2H2-type.				box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding				0		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)												0.425532	115.526325	115.970512	40	54	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)	Missense_Mutation	SNP	44452922	44452922	11153	13	C	T	T	29	29	NUFIP1	T	2	2
ESRRB	2103	broad.mit.edu	36	14	75975543	75975543	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr14:75975543C>T	uc001xso.1	+	c.94C>T	c.(94-96)CAC>TAC	p.H32Y	ESRRB_uc001xsp.1_Missense_Mutation_p.H32Y|ESRRB_uc001xsq.1_Missense_Mutation_p.H32Y|ESRRB_uc001xsr.1_Missense_Mutation_p.H32Y	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	32					regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1														0.5	67.420268	67.420268	23	23	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(234;0.0213)	Missense_Mutation	SNP	75975543	75975543	5454	14	C	T	T	21	21	ESRRB	T	2	2
SH2D7	646892	broad.mit.edu	36	15	76173570	76173570	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:76173570C>G	uc010blb.1	+	c.238C>G	c.(238-240)CGA>GGA	p.R80G		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	80	SH2.										0														0.210526	7.98784	9.462541	4	15	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	76173570	76173570	14730	15	C	G	G	23	23	SH2D7	G	3	3
ZNF536	9745	broad.mit.edu	36	19	35627743	35627743	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:35627743C>G	uc002nsu.1	+	c.1434C>G	c.(1432-1434)CAC>CAG	p.H478Q	ZNF536_uc010edd.1_Missense_Mutation_p.H478Q	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)	9	Esophageal squamous(110;0.0834)													0.266667	81.169304	86.321919	28	77	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	35627743	35627743	18568	19	C	G	G	19	19	ZNF536	G	3	3
ATCAY	85300	broad.mit.edu	36	19	3858818	3858818	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:3858818G>A	uc002lyy.2	+	c.445G>A	c.(445-447)GCC>ACC	p.A149T	ATCAY_uc010dts.1_5'Flank	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	149					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)												0.288136	42.447982	44.825138	17	42	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)	Missense_Mutation	SNP	3858818	3858818	1096	19	G	A	A	38	38	ATCAY	A	1	1
MLL4	9757	broad.mit.edu	36	19	40906620	40906620	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:40906620C>G	uc010eei.1	+	c.3206C>G	c.(3205-3207)TCC>TGC	p.S1069C		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1069					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)													0.521739	40.600674	40.610097	12	11	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(66;0.0515)		Missense_Mutation	SNP	40906620	40906620	10013	19	C	G	G	30	30	MLL4	G	3	3
COL5A3	50509	broad.mit.edu	36	19	9938022	9938022	+	Missense_Mutation	SNP	T	G	G			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr19:9938022T>G	uc002mmq.1	-	c.4750A>C	c.(4750-4752)ACC>CCC	p.T1584P		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1584	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)	9														0.363636	7.717784	7.929038	4	7	TT		KEEP	---	---	---	---	capture	Epithelial(33;7.11e-05)		Missense_Mutation	SNP	9938022	9938022	3836	19	T	G	G	58	58	COL5A3	G	4	4
OR2M4	26245	broad.mit.edu	36	1	246468934	246468934	+	Silent	SNP	T	C	C			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:246468934T>C	uc001iec.1	+	c.81T>C	c.(79-81)CTT>CTC	p.L27L		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)													0.322835	263.672457	270.744794	82	172	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.0245)		Silent	SNP	246468934	246468934	11418	1	T	C	C	64	64	OR2M4	C	4	4
ZNF672	79894	broad.mit.edu	36	1	247109073	247109073	+	Missense_Mutation	SNP	T	G	G			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:247109073T>G	uc001iex.1	+	c.977T>G	c.(976-978)CTC>CGC	p.L326R	ZNF672_uc001iey.2_Missense_Mutation_p.L326R	NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	326	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)												0.333333	22.96559	23.630014	9	18	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.00805)		Missense_Mutation	SNP	247109073	247109073	18674	1	T	G	G	54	54	ZNF672	G	4	4
ZNF692	55657	broad.mit.edu	36	1	247118101	247118101	+	Silent	SNP	G	T	T			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:247118101G>T	uc001ifc.1	-	c.430C>A	c.(430-432)CGG>AGG	p.R144R	ZNF692_uc001iez.1_5'Flank|ZNF692_uc001ifa.1_5'UTR|ZNF692_uc001ifb.1_5'UTR|ZNF692_uc001ifd.1_Silent_p.R144R|ZNF692_uc001ife.1_Non-coding_Transcript|ZNF692_uc001iff.1_Silent_p.R144R	NM_017865	NP_060335	Q9BU19	ZN692_HUMAN	zinc finger protein 692 isoform 2	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)												0.297753	145.013825	151.518305	53	125	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.00805)		Silent	SNP	247118101	247118101	18692	1	G	T	T	37	37	ZNF692	T	3	3
SLC4A11	83959	broad.mit.edu	36	20	3157652	3157652	+	Missense_Mutation	SNP	A	C	C			TCGA-06-0219-01	TCGA-06-0219-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr20:3157652A>C	uc002wig.1	-	c.2072T>G	c.(2071-2073)GTG>GGG	p.V691G	SLC4A11_uc002wih.1_Non-coding_Transcript	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	691	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						NSCLC(190;922 2139 10266 10292 38692)								0.257143	7.155339	9.224762	9	26	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	3157652	3157652	15149	20	A	C	C	6	6	SLC4A11	C	4	4
C20orf152	140894	broad.mit.edu	36	20	34036005	34036005	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:34036005G>A	uc002xer.1	+	c.607G>A	c.(607-609)GTC>ATC	p.V203I	C20orf152_uc002xes.1_Missense_Mutation_p.V203I|C20orf152_uc010gfp.1_Non-coding_Transcript	NM_080834	NP_543024	Q96M20	CT152_HUMAN	hypothetical protein LOC140894	203	cNMP.										0	Breast(12;0.00631)													0.386555	132.638318	133.974611	46	73	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	34036005	34036005	2169	20	G	A	A	40	40	C20orf152	A	1	1
TRPM2	7226	broad.mit.edu	36	21	44650974	44650974	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr21:44650974G>C	uc010gpt.1	+	c.2860G>C	c.(2860-2862)GCC>CCC	p.A954P	TRPM2_uc002zet.1_Missense_Mutation_p.A954P|TRPM2_uc002zeu.1_Missense_Mutation_p.A954P|TRPM2_uc002zew.1_Missense_Mutation_p.A954P|TRPM2_uc002zex.1_Missense_Mutation_p.A740P|TRPM2_uc002zey.1_Missense_Mutation_p.A467P	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	954	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3														0.2	7.388514	9.063481	4	16	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	44650974	44650974	17137	21	G	C	C	42	42	TRPM2	C	3	3
SLC4A10	57282	broad.mit.edu	36	2	162512454	162512454	+	Missense_Mutation	SNP	T	C	C			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:162512454T>C	uc002ubx.2	+	c.2236T>C	c.(2236-2238)TTC>CTC	p.F746L	SLC4A10_uc002uby.2_Missense_Mutation_p.F716L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	746	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5														0.346715	306.165312	311.838086	95	179	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	162512454	162512454	15148	2	T	C	C	60	60	SLC4A10	C	4	4
HS1BP3	64342	broad.mit.edu	36	2	20704403	20704403	+	Nonsense_Mutation	SNP	C	A	A			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:20704403C>A	uc002rdw.1	-	c.217G>T	c.(217-219)GAG>TAG	p.E73*	HS1BP3_uc002rdx.1_Nonsense_Mutation_p.E73*|HS1BP3_uc002rdy.2_Nonsense_Mutation_p.E73*	NM_022460	NP_071905	Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	73	PX.				cell communication		phosphatidylinositol binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)													0.285211	227.979019	239.725088	81	203	CC		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	20704403	20704403	7655	2	C	A	A	31	31	HS1BP3	A	5	3
TRAT1	50852	broad.mit.edu	36	3	110050747	110050747	+	Nonsense_Mutation	SNP	G	T	T			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:110050747G>T	uc003dxi.1	+	c.259G>T	c.(259-261)GAG>TAG	p.E87*	TRAT1_uc010hpx.1_Nonsense_Mutation_p.E50*	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	87	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity				0														0.298969	75.232876	78.738867	29	68	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	110050747	110050747	17010	3	G	T	T	33	33	TRAT1	T	5	3
UROC1	131669	broad.mit.edu	36	3	127719133	127719133	+	Silent	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:127719133C>T	uc010hsi.1	-	c.120G>A	c.(118-120)GAG>GAA	p.E40E	UROC1_uc003eiz.1_Silent_p.E40E	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1	40					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1														0.358209	72.180472	73.367143	24	43	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(114;0.17)	Silent	SNP	127719133	127719133	17590	3	C	T	T	32	32	UROC1	T	2	2
CLCN2	1181	broad.mit.edu	36	3	185553829	185553829	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:185553829C>T	uc003foi.2	-	c.1931G>A	c.(1930-1932)CGC>CAC	p.R644H	CLCN2_uc003foh.2_Missense_Mutation_p.R168H|CLCN2_uc010hya.1_Missense_Mutation_p.R627H	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	644	Cytoplasmic (By similarity).		R -> C (no effect).			chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)				Lubiprostone(DB01046)									0.382716	89.526205	90.495516	31	50	CC		KEEP	---	---	---	---	capture	Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Missense_Mutation	SNP	185553829	185553829	3599	3	C	T	T	27	27	CLCN2	T	1	1
LPP	4026	broad.mit.edu	36	3	189809823	189809823	+	Nonsense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:189809823C>T	uc003frs.1	+	c.610C>T	c.(610-612)CAG>TAG	p.Q204*	LPP_uc003frt.2_Nonsense_Mutation_p.Q204*	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	204	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|ovary(1)	162	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)								184				0.340782	152.103025	156.121706	61	118	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(93;0.00602)	Nonsense_Mutation	SNP	189809823	189809823	9296	3	C	T	T	29	29	LPP	T	5	2
RPL15	6138	broad.mit.edu	36	3	23934485	23934485	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:23934485G>A	uc003ccn.1	+	c.131G>A	c.(130-132)CGG>CAG	p.R44Q	NKIRAS1_uc003ccj.1_5'Flank|NKIRAS1_uc003cck.1_Intron|NKIRAS1_uc003ccl.1_5'Flank|NKIRAS1_uc003ccm.1_5'Flank|RPL15_uc003cco.2_Missense_Mutation_p.R44Q|RPL15_uc003ccp.1_Missense_Mutation_p.R44Q|RPL15_uc003ccq.1_Missense_Mutation_p.R44Q|RPL15_uc003ccr.1_Missense_Mutation_p.R44Q	NM_002948	NP_002939	P61313	RL15_HUMAN	ribosomal protein L15	44					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			ovary(1)	1														0.346939	99.340308	101.357848	34	64	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	23934485	23934485	14041	3	G	A	A	39	39	RPL15	A	1	1
ZNF518B	85460	broad.mit.edu	36	4	10054409	10054409	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:10054409G>T	uc003gmn.1	-	c.2642C>A	c.(2641-2643)TCC>TAC	p.S881Y	ZNF518B_uc010idn.1_Missense_Mutation_p.S881Y	NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	881					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3														0.385475	187.159079	189.207029	69	110	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	10054409	10054409	18557	4	G	T	T	41	41	ZNF518B	T	3	3
SLCO6A1	133482	broad.mit.edu	36	5	101862337	101862337	+	Silent	SNP	T	C	C			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr5:101862337T>C	uc003knn.2	-	c.111A>G	c.(109-111)GGA>GGG	p.G37G	SLCO6A1_uc003kno.2_Silent_p.G37G|SLCO6A1_uc003knp.1_Silent_p.G37G|SLCO6A1_uc003knq.1_Silent_p.G37G	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	37	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|central_nervous_system(1)	4		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)												0.304	334.178915	346.995198	114	261	TT		KEEP	---	---	---	---	capture		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)	Silent	SNP	101862337	101862337	15229	5	T	C	C	62	62	SLCO6A1	C	4	4
PCDHGA2	56113	broad.mit.edu	36	5	140700109	140700109	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140700109G>A	uc003ljk.1	+	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljj.1_Missense_Mutation_p.E463K	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	463	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1														0.325	105.987237	109.24663	39	81	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Missense_Mutation	SNP	140700109	140700109	11974	5	G	A	A	37	37	PCDHGA2	A	1	1
PRDM9	56979	broad.mit.edu	36	5	23563385	23563385	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:23563385C>T	uc003jgo.1	+	c.2431C>T	c.(2431-2433)CGG>TGG	p.R811W		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	811	C2H2-type 12.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6														0.19171	68.083832	85.222705	37	156	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	23563385	23563385	12906	5	C	T	T	27	27	PRDM9	T	1	1
C6orf167	253714	broad.mit.edu	36	6	97809152	97809152	+	Splice_Site_SNP	SNP	A	C	C			TCGA-06-0219-01	TCGA-06-0219-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr6:97809152A>C	uc003ppb.1	-	c.1119_splice	c.e10+1	p.M373_splice	C6orf167_uc010kcn.1_Splice_Site_SNP_p.M147_splice|C6orf167_uc010kco.1_Splice_Site_SNP_p.M109_splice|C6orf167_uc003ppc.1_Missense_Mutation_p.V374G	NM_198468	NP_940870			hypothetical protein LOC253714						double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)												0.238806	44.090696	48.247724	16	51	AA		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(108;0.0457)	Splice_Site_SNP	SNP	97809152	97809152	2447	6	A	C	C	14	14	C6orf167	C	5	4
TRIM56	81844	broad.mit.edu	36	7	100517912	100517912	+	Missense_Mutation	SNP	A	C	C			TCGA-06-0219-01	TCGA-06-0219-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:100517912A>C	uc003uxq.1	+	c.599A>C	c.(598-600)CAC>CCC	p.H200P	TRIM56_uc003uxr.2_Missense_Mutation_p.H200P|TRIM56_uc010lhp.1_Missense_Mutation_p.H200P	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	200	B box-type 2.				defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					Ovarian(89;1092 1379 22756 38989 39611)								0.352941	9.224958	9.601238	6	11	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	100517912	100517912	17076	7	A	C	C	6	6	TRIM56	C	4	4
TSGA13	114960	broad.mit.edu	36	7	130016349	130016349	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:130016349C>T	uc003vqi.1	-	c.149G>A	c.(148-150)CGG>CAG	p.R50Q	TSGA13_uc003vqj.1_Missense_Mutation_p.R50Q	NM_052933	NP_443165	Q96PP4	TSG13_HUMAN	testis specific, 13	50										ovary(2)	2	Melanoma(18;0.0435)													0.262821	112.941517	120.854891	41	115	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	130016349	130016349	17170	7	C	T	T	23	23	TSGA13	T	1	1
CSMD3	114788	broad.mit.edu	36	8	113325934	113325934	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:113325934C>T	uc003ynu.1	-	c.10267G>A	c.(10267-10269)GTA>ATA	p.V3423I	CSMD3_uc003ynt.1_Missense_Mutation_p.V3383I|CSMD3_uc003ynv.1_Missense_Mutation_p.V3217I|CSMD3_uc003yns.1_Missense_Mutation_p.V2625I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3423	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane		p.V3423I(1)		ovary(20)|lung(11)|kidney(8)|large_intestine(6)|skin(3)|central_nervous_system(2)|urinary_tract(1)|breast(1)	52										2888	TCGA Ovarian(7;0.080)			0.254098	77.780496	84.466831	31	91	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	113325934	113325934	4087	8	C	T	T	19	19	CSMD3	T	1	1
FAM83H	286077	broad.mit.edu	36	8	144882286	144882286	+	Missense_Mutation	SNP	T	G	G			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr8:144882286T>G	uc003yzk.1	-	c.1333A>C	c.(1333-1335)ACC>CCC	p.T445P	FAM83H_uc010mfk.1_Non-coding_Transcript	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	hypothetical protein LOC286077	445					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)													0.153846	6.482565	9.462463	4	22	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)		Missense_Mutation	SNP	144882286	144882286	5866	8	T	G	G	58	58	FAM83H	G	4	4
ADAM7	8756	broad.mit.edu	36	8	24395574	24395574	+	Silent	SNP	G	A	A			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:24395574G>A	uc003xeb.1	+	c.735G>A	c.(733-735)ACG>ACA	p.T245T	ADAM7_uc003xec.2_Silent_p.T17T	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	245	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			kidney(1)	1		Prostate(55;0.0181)												0.297872	73.865315	77.297458	28	66	GG		KEEP	---	---	---	---	capture		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)	Silent	SNP	24395574	24395574	252	8	G	A	A	40	40	ADAM7	A	1	1
OPRK1	4986	broad.mit.edu	36	8	54325894	54325894	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0219-01	TCGA-06-0219-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:54325894C>T	uc003xrh.1	-	c.257G>A	c.(256-258)CGA>CAA	p.R86Q	OPRK1_uc003xri.1_Missense_Mutation_p.R86Q|OPRK1_uc010lyc.1_5'UTR	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	86	Cytoplasmic (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)	1		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)									0.288889	37.656844	39.454537	13	32	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	54325894	54325894	11291	8	C	T	T	23	23	OPRK1	T	1	1
KCNS2	3788	broad.mit.edu	36	8	99510612	99510612	+	Missense_Mutation	SNP	T	C	C			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr8:99510612T>C	uc003yin.1	+	c.1229T>C	c.(1228-1230)TTC>TCC	p.F410S	KCNS2_uc010mbl.1_Missense_Mutation_p.F410S	NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	410	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)					Pancreas(138;844 2489 9202 24627)								0.26	148.110041	158.539316	52	148	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(57;0.0448)		Missense_Mutation	SNP	99510612	99510612	8394	8	T	C	C	62	62	KCNS2	C	4	4
CYLC2	1539	broad.mit.edu	36	9	104807521	104807521	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0219-01	TCGA-06-0219-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:104807521G>T	uc004bbs.1	+	c.787G>T	c.(787-789)GAT>TAT	p.D263Y		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	263	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)												0.25	32.419667	35.603934	14	42	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	104807521	104807521	4307	9	G	T	T	33	33	CYLC2	T	3	3
FRMD3	257019	broad.mit.edu	36	9	85114342	85114342	+	Silent	SNP	T	C	C			TCGA-06-0219-01	TCGA-06-0219-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr9:85114342T>C	uc004ams.1	-	c.855A>G	c.(853-855)GCA>GCG	p.A285A	FRMD3_uc004amr.1_Silent_p.A271A	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	285	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2														0.2625	51.437626	55.520726	21	59	TT		KEEP	---	---	---	---	capture			Silent	SNP	85114342	85114342	6300	9	T	C	C	51	51	FRMD3	C	4	4
