Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
CASP1	834	broad.mit.edu	36	11	104405653	104405653	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:104405653G>A	uc001pif.1	-	c.811C>T	c.(811-813)CCA>TCA	p.P271S	CASP1_uc001pig.1_Missense_Mutation_p.P178S|CASP1_uc001pih.1_Missense_Mutation_p.P250S|CASP1_uc001pii.1_Missense_Mutation_p.P178S|CASP1_uc001pij.1_Intron|CASP1_uc001pik.1_Missense_Mutation_p.P234S|CASP1_uc001pil.1_Missense_Mutation_p.P178S|CASP1_uc001pim.2_Missense_Mutation_p.P271S|CASP1_uc009yxi.1_Missense_Mutation_p.P250S|CASP1_uc001pin.1_Missense_Mutation_p.P271S|CASP1_uc009yxj.1_Missense_Mutation_p.P116S	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	271					apoptosis|cellular response to mechanical stimulus|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)			Minocycline(DB01017)|Penicillamine(DB00859)	NSCLC(41;1246 1743 4934)				268				0.206186	45.44387	53.209298	20	77	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Missense_Mutation	SNP	104405653	104405653	2787	11	G	A	A	43	43	CASP1	A	2	2
OR5P2	120065	broad.mit.edu	36	11	7774741	7774741	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:7774741C>T	uc001mfp.1	-	c.325G>A	c.(325-327)GTC>ATC	p.V109I		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V109I(1)		ovary(2)|central_nervous_system(1)	3														0.419355	226.021892	227.075887	78	108	CC		KEEP	---	---	---	---	capture		Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Missense_Mutation	SNP	7774741	7774741	11588	11	C	T	T	19	19	OR5P2	T	1	1
DDIT3	1649	broad.mit.edu	36	12	56197363	56197363	+	Missense_Mutation	SNP	C	A	A			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:56197363C>A	uc009zps.1	-	c.163G>T	c.(163-165)GAT>TAT	p.D55Y	MARS_uc001sof.1_Non-coding_Transcript|DDIT3_uc001soi.1_Missense_Mutation_p.D32Y|DDIT3_uc009zpt.1_Missense_Mutation_p.D55Y	NM_004083	NP_004074	P35638	DDIT3_HUMAN	DNA-damage-inducible transcript 3	32					cell cycle arrest|cell redox homeostasis|mRNA transcription from RNA polymerase II promoter|negative regulation of determination of dorsal identity|regulation of transcription in response to stress|response to DNA damage stimulus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding	p.D32Y(1)	FUS/DDIT3(623)|EWSR1/DDIT3(43)	soft_tissue(666)|large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	670						GBM(112;1383 1547 7626 23045 28770)				27				0.317568	629.972614	651.863166	235	505	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	56197363	56197363	4501	12	C	A	A	32	32	DDIT3	A	3	3
PIP4K2C	79837	broad.mit.edu	36	12	56281115	56281115	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:56281115C>G	uc001sot.1	+	c.1068C>G	c.(1066-1068)ATC>ATG	p.I356M	PIP4K2C_uc001sou.1_Missense_Mutation_p.I356M	NM_024779	NP_079055	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	356	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)									258				0.086207	60.945	221.843653	80	848	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	56281115	56281115	12362	12	C	G	G	30	30	PIP4K2C	G	3	3
JAG2	3714	broad.mit.edu	36	14	104685720	104685720	+	Missense_Mutation	SNP	T	G	G			TCGA-06-0238-01	TCGA-06-0238-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr14:104685720T>G	uc001yqg.1	-	c.2122A>C	c.(2122-2124)ACC>CCC	p.T708P	JAG2_uc010axf.1_5'Flank|JAG2_uc001yqf.1_Missense_Mutation_p.T112P|JAG2_uc001yqh.1_Missense_Mutation_p.T670P	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	708	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)	3		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)								501				0.5	20.783322	20.783322	8	8	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)	Missense_Mutation	SNP	104685720	104685720	8239	14	T	G	G	58	58	JAG2	G	4	4
TJP1	7082	broad.mit.edu	36	15	27790443	27790443	+	Missense_Mutation	SNP	T	C	C			TCGA-06-0238-01	TCGA-06-0238-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr15:27790443T>C	uc010azl.1	-	c.4220A>G	c.(4219-4221)TAT>TGT	p.Y1407C	TJP1_uc001zcq.1_Missense_Mutation_p.Y1343C|TJP1_uc001zcr.1_Missense_Mutation_p.Y1419C|TJP1_uc001zcs.1_Missense_Mutation_p.Y1339C	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1419					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|pancreas(1)	5		all_lung(180;7.48e-11)|Breast(32;0.000153)				Melanoma(77;681 1843 6309 6570)								0.122581	24.13128	45.773726	19	136	TT		KEEP	---	---	---	---	capture		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)	Missense_Mutation	SNP	27790443	27790443	16458	15	T	C	C	49	49	TJP1	C	4	4
ARID3B	10620	broad.mit.edu	36	15	72623332	72623332	+	Missense_Mutation	SNP	T	G	G			TCGA-06-0238-01	TCGA-06-0238-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr15:72623332T>G	uc002aye.1	+	c.2T>G	c.(1-3)ATG>AGG	p.M1R	ARID3B_uc002ayc.2_Missense_Mutation_p.M1R|ARID3B_uc002ayd.1_Missense_Mutation_p.M1R	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	1					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0														0.25	7.688102	9.104376	6	18	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	72623332	72623332	932	15	T	G	G	51	51	ARID3B	G	4	4
ARNT2	9915	broad.mit.edu	36	15	78671007	78671007	+	Silent	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr15:78671007G>A	uc002bfr.1	+	c.1962G>A	c.(1960-1962)TCG>TCA	p.S654S	ARNT2_uc002bfs.1_Silent_p.S643S	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	654					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription regulator activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5														0.111111	16.470162	36.617727	15	120	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(143;0.134)		Silent	SNP	78671007	78671007	984	15	G	A	A	39	39	ARNT2	A	1	1
RSL1D1	26156	broad.mit.edu	36	16	11839191	11839191	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:11839191G>T	uc002dbp.1	-	c.1427C>A	c.(1426-1428)ACC>AAC	p.T476N	RSL1D1_uc010buv.1_Missense_Mutation_p.T475N	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	476					regulation of protein localization|RNA processing|translation	nucleolus|ribosome	protein binding|RNA binding|structural constituent of ribosome				0														0.352792	400.913681	408.439983	139	255	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	11839191	11839191	14180	16	G	T	T	44	44	RSL1D1	T	3	3
SMG1	23049	broad.mit.edu	36	16	18782634	18782634	+	Silent	SNP	A	T	T			TCGA-06-0238-01	TCGA-06-0238-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr16:18782634A>T	uc002dfm.1	-	c.3534T>A	c.(3532-3534)TCT>TCA	p.S1178S	SMG1_uc010bwb.1_Silent_p.S1038S	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1178	FAT.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|lung(4)|kidney(2)|stomach(1)|ovary(1)	13										1101				0.296875	52.598232	54.960531	19	45	AA		KEEP	---	---	---	---	capture			Silent	SNP	18782634	18782634	15293	16	A	T	T	3	3	SMG1	T	4	4
NOTCH3	4854	broad.mit.edu	36	19	15159114	15159114	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:15159114C>T	uc002nan.1	-	c.1642G>A	c.(1642-1644)GAC>AAC	p.D548N	NOTCH3_uc002nao.1_Missense_Mutation_p.D548N	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3	548	Extracellular (Potential).|EGF-like 14; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			ovary(5)|lung(2)|central_nervous_system(1)	8										417				0.324675	71.955412	74.052218	25	52	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)		Missense_Mutation	SNP	15159114	15159114	10953	19	C	T	T	31	31	NOTCH3	T	1	1
NLRP2	55655	broad.mit.edu	36	19	60186319	60186319	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:60186319C>T	uc002qij.1	+	c.1441C>T	c.(1441-1443)CGT>TGT	p.R481C	NLRP2_uc010esm.1_Non-coding_Transcript|NLRP2_uc010esn.1_Missense_Mutation_p.R457C|NLRP2_uc010eso.1_Missense_Mutation_p.R478C|NLRP2_uc010esp.1_Missense_Mutation_p.R459C	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	481	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)	1														0.287037	84.673898	89.072692	31	77	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)	Missense_Mutation	SNP	60186319	60186319	10880	19	C	T	T	23	23	NLRP2	T	1	1
ZNF317	57693	broad.mit.edu	36	19	9132619	9132619	+	Missense_Mutation	SNP	T	A	A			TCGA-06-0238-01	TCGA-06-0238-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr19:9132619T>A	uc002mku.2	+	c.1298T>A	c.(1297-1299)CTT>CAT	p.L433H	ZNF317_uc002mkv.2_Missense_Mutation_p.L292H|ZNF317_uc002mkw.2_Missense_Mutation_p.L401H|ZNF317_uc002mkx.2_Missense_Mutation_p.L348H|ZNF317_uc002mky.2_Missense_Mutation_p.L316H	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	433	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0														0.425743	130.908972	131.394688	43	58	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	9132619	9132619	18427	19	T	A	A	56	56	ZNF317	A	4	4
KPRP	448834	broad.mit.edu	36	1	150999430	150999430	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150999430C>T	uc001fal.1	+	c.742C>T	c.(742-744)CGC>TGC	p.R248C	KPRP_uc009wnn.1_Missense_Mutation_p.R248C	NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	248						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)													0.263158	90.472794	97.215127	35	98	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.206)		Missense_Mutation	SNP	150999430	150999430	8751	1	C	T	T	23	23	KPRP	T	1	1
OR10Z1	128368	broad.mit.edu	36	1	156843624	156843624	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:156843624G>A	uc001fss.1	+	c.772G>A	c.(772-774)GTG>ATG	p.V258M		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)													0.355795	360.247847	366.933461	132	239	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	156843624	156843624	11329	1	G	A	A	40	40	OR10Z1	A	1	1
SPTA1	6708	broad.mit.edu	36	1	156917122	156917122	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:156917122C>G	uc001fst.1	-	c.553G>C	c.(553-555)GAG>CAG	p.E185Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	185	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|breast(1)	5	all_hematologic(112;0.0378)													0.367816	213.753585	216.426643	64	110	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	156917122	156917122	15630	1	C	G	G	30	30	SPTA1	G	3	3
ZNF496	84838	broad.mit.edu	36	1	245530909	245530909	+	Silent	SNP	C	T	T			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:245530909C>T	uc009xgv.1	-	c.1407G>A	c.(1405-1407)AAG>AAA	p.K469K	ZNF496_uc001ico.1_Silent_p.K433K|ZNF496_uc001icp.1_Silent_p.K433K	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	433					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)													0.356589	128.874084	131.22762	46	83	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.00703)		Silent	SNP	245530909	245530909	18539	1	C	T	T	28	28	ZNF496	T	2	2
OR2T34	127068	broad.mit.edu	36	1	246804375	246804375	+	Missense_Mutation	SNP	C	A	A			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:246804375C>A	uc001iep.1	-	c.307G>T	c.(307-309)GGG>TGG	p.G103W		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	103	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)													0.447368	157.107658	157.383218	51	63	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.0265)		Missense_Mutation	SNP	246804375	246804375	11431	1	C	A	A	21	21	OR2T34	A	3	3
TSPO	706	broad.mit.edu	36	22	41888789	41888789	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:41888789G>C	uc003bdn.1	+	c.358G>C	c.(358-360)GCA>CCA	p.A120P	TSPO_uc003bdo.1_Missense_Mutation_p.G26A	NM_000714	NP_000705	B1AH88	TSPOB_HUMAN	translocator protein isoform PBR	Error:Variant_position_missing_in_B1AH88_after_alignment											0		Ovarian(80;0.0694)												0.3	6.517896	6.877472	3	7	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	41888789	41888789	17206	22	G	C	C	42	42	TSPO	C	3	3
IWS1	55677	broad.mit.edu	36	2	127955191	127955191	+	Nonsense_Mutation	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:127955191G>A	uc002ton.1	-	c.2359C>T	c.(2359-2361)CGA>TGA	p.R787*		NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	787						nucleus	DNA binding|transcription regulator activity			ovary(1)	1	Colorectal(110;0.1)													0.435714	190.755897	191.260063	61	79	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(221;0.0735)	Nonsense_Mutation	SNP	127955191	127955191	8235	2	G	A	A	37	37	IWS1	A	5	1
TEKT4	150483	broad.mit.edu	36	2	94901296	94901296	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:94901296G>A	uc002stw.1	+	c.245G>A	c.(244-246)CGC>CAC	p.R82H	TEKT4_uc010fhr.1_Non-coding_Transcript	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	82					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)	2														0.444444	35.49612	35.568764	12	15	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	94901296	94901296	16282	2	G	A	A	38	38	TEKT4	A	1	1
PCDH7	5099	broad.mit.edu	36	4	30334968	30334968	+	Silent	SNP	A	G	G			TCGA-06-0238-01	TCGA-06-0238-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:30334968A>G	uc010iez.1	+	c.2685A>G	c.(2683-2685)AAA>AAG	p.K895K	PCDH7_uc003gsj.1_Silent_p.K942K|PCDH7_uc003gsk.1_Silent_p.K942K	NM_032457	NP_115833	O60245	PCDH7_HUMAN	protocadherin 7 isoform c precursor	942	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4														0.404959	154.710834	155.699724	49	72	AA		KEEP	---	---	---	---	capture			Silent	SNP	30334968	30334968	11936	4	A	G	G	4	4	PCDH7	G	4	4
PCDHA1	56147	broad.mit.edu	36	5	140147805	140147805	+	Silent	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140147805G>A	uc003lhb.1	+	c.1746G>A	c.(1744-1746)CCG>CCA	p.P582P	PCDHA1_uc003lha.1_Intron|PCDHA1_uc003lgz.1_Silent_p.P582P	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	582	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding				0														0.367647	134.407318	136.503983	50	86	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Silent	SNP	140147805	140147805	11939	5	G	A	A	38	38	PCDHA1	A	1	1
PCDHGA2	56113	broad.mit.edu	36	5	140701069	140701069	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140701069G>A	uc003ljk.1	+	c.2347G>A	c.(2347-2349)GAG>AAG	p.E783K	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA2_uc003ljj.1_Missense_Mutation_p.E783K|PCDHGA3_uc003ljl.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	783	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1														0.306878	162.27178	168.561085	58	131	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Missense_Mutation	SNP	140701069	140701069	11974	5	G	A	A	41	41	PCDHGA2	A	2	2
ODZ2	57451	broad.mit.edu	36	5	167559676	167559676	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:167559676C>G	uc010jjd.1	+	c.3365C>G	c.(3364-3366)GCG>GGG	p.A1122G	ODZ2_uc003lzr.2_Missense_Mutation_p.A899G|ODZ2_uc003lzt.2_Missense_Mutation_p.A495G|ODZ2_uc010jje.1_Missense_Mutation_p.A393G	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)												0.377778	53.357946	53.949815	17	28	CC		KEEP	---	---	---	---	capture	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)	Missense_Mutation	SNP	167559676	167559676	11240	5	C	G	G	27	27	ODZ2	G	3	3
DAXX	1616	broad.mit.edu	36	6	33395316	33395316	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0238-01	TCGA-06-0238-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr6:33395316A>G	uc003oec.1	-	c.1759T>C	c.(1759-1761)TCC>CCC	p.S587P	ZBTB22_uc003oeb.1_5'Flank|ZBTB22_uc010juu.1_5'Flank|ZBTB22_uc010juv.1_5'Flank|DAXX_uc003oed.1_Missense_Mutation_p.S587P	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	587	Interaction with MAP3K5.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)	22										125				0.433121	236.094205	236.702645	68	89	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	33395316	33395316	4410	6	A	G	G	9	9	DAXX	G	4	4
UNC5CL	222643	broad.mit.edu	36	6	41108805	41108805	+	Silent	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:41108805G>A	uc003opi.1	-	c.745C>T	c.(745-747)CTG>TTG	p.L249L		NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	249	Cytoplasmic (Potential).|Interaction with RELA and NFKB1.				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)													0.285714	12.69542	13.271529	4	10	GG		KEEP	---	---	---	---	capture			Silent	SNP	41108805	41108805	17552	6	G	A	A	34	34	UNC5CL	A	2	2
ASZ1	136991	broad.mit.edu	36	7	116812053	116812053	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0238-01	TCGA-06-0238-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:116812053A>G	uc003vjb.2	-	c.650T>C	c.(649-651)ATG>ACG	p.M217T		NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	217	ANK 6.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)													0.221774	146.495886	164.15635	55	193	AA		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(10;0.000512)		Missense_Mutation	SNP	116812053	116812053	1088	7	A	G	G	8	8	ASZ1	G	4	4
KEL	3792	broad.mit.edu	36	7	142368653	142368653	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:142368653G>A	uc003wcb.1	-	c.139C>T	c.(139-141)CGG>TGG	p.R47W		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	47	Cytoplasmic (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)													0.275862	18.694796	20.002437	8	21	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	142368653	142368653	8448	7	G	A	A	38	38	KEL	A	1	1
TFPI2	7980	broad.mit.edu	36	7	93354524	93354524	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:93354524G>A	uc003unb.1	-	c.634C>T	c.(634-636)CGT>TGT	p.R212C	GNGT1_uc003umx.1_Intron|TFPI2_uc003umy.1_Missense_Mutation_p.R206C|TFPI2_uc003umz.1_Silent_p.N180N|TFPI2_uc003una.1_Missense_Mutation_p.R195C|TFPI2_uc010lfg.1_Missense_Mutation_p.R82C	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2	206	BPTI/Kunitz inhibitor 3.				blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)													0.259459	128.321359	138.010706	48	137	GG		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.000967)		Missense_Mutation	SNP	93354524	93354524	16337	7	G	A	A	40	40	TFPI2	A	1	1
PTCD1	26024	broad.mit.edu	36	7	98861174	98861174	+	Missense_Mutation	SNP	A	C	C			TCGA-06-0238-01	TCGA-06-0238-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:98861174A>C	uc003uqh.1	-	c.917T>G	c.(916-918)GTG>GGG	p.V306G	PDAP1_uc010lfv.1_Intron	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	306	PPR 5.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)													0.25	6.527975	7.702435	5	15	AA		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.215)		Missense_Mutation	SNP	98861174	98861174	13181	7	A	C	C	6	6	PTCD1	C	4	4
PUF60	22827	broad.mit.edu	36	8	144971776	144971776	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0238-01	TCGA-06-0238-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:144971776C>G	uc003yzs.1	-	c.982G>C	c.(982-984)GCA>CCA	p.A328P	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzq.1_Missense_Mutation_p.A285P|PUF60_uc003yzr.1_Missense_Mutation_p.A268P|PUF60_uc003yzt.1_Missense_Mutation_p.A311P|PUF60_uc003yzu.1_Missense_Mutation_p.A317P	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	328	Ala-rich.|Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)													0.307692	10.228757	10.638924	4	9	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)		Missense_Mutation	SNP	144971776	144971776	13282	8	C	G	G	25	25	PUF60	G	3	3
MAP3K15	389840	broad.mit.edu	36	X	19341407	19341407	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0238-01	TCGA-06-0238-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:19341407G>T	uc004czk.1	-	c.14C>A	c.(13-15)ACC>AAC	p.T5N	MAP3K15_uc004czj.1_5'UTR	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	Error:Variant_position_missing_in_Q6ZN16_after_alignment					protein phosphorylation		ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|skin(1)	6	Hepatocellular(33;0.183)													0.674157	412.76297	417.573659	120	58	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	19341407	19341407	9632	23	G	T	T	44	44	MAP3K15	T	3	3
NLRP6	171389	broad.mit.edu	36	11	271344	271344	+	Frame_Shift_Del	DEL	A	-	-			TCGA-06-0238-01	TCGA-06-0238-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:271344_271344delA	uc001loq.1	+	c.1610_1610delA	c.(1609-1611)CACfs	p.H537fs	NLRP6_uc009ybu.1_Frame_Shift_Del_p.H537fs	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	537						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)						236				0.39			7	11				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	271344	271344	10884	11	A	-	-	6	6	NLRP6	-	5	5
TP53	7157	broad.mit.edu	36	17	7518283	7518291	+	In_Frame_Del	DEL	GGAACTGTT	-	-			TCGA-06-0238-01	TCGA-06-0238-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:7518283_7518291delGGAACTGTT	uc002gim.2	-	c.715_723delAACAGTTCC	c.(715-723)AACAGTTCCdel	p.NSS239del	TP53_uc002gig.1_In_Frame_Del_p.NSS239del|TP53_uc002gih.1_In_Frame_Del_p.NSS239del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.NSS107del|TP53_uc010cng.1_In_Frame_Del_p.NSS107del|TP53_uc002gii.1_In_Frame_Del_p.NSS107del|TP53_uc010cnh.1_In_Frame_Del_p.NSS239del|TP53_uc010cni.1_In_Frame_Del_p.NSS239del|TP53_uc002gij.2_In_Frame_Del_p.NSS239del|TP53_uc010cnj.1_Non-coding_Transcript|TP53_uc002gin.2_In_Frame_Del_p.NSS146del|TP53_uc002gio.2_In_Frame_Del_p.NSS107del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	239_241	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		S -> A (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.S241F(72)|p.N239D(28)|p.S241C(24)|p.N239S(19)|p.C242fs*5(15)|p.S240G(14)|p.N239fs*25(12)|p.S240R(8)|p.S241fs*6(8)|p.S241Y(7)|p.N239Y(6)|p.S241A(6)|p.S240I(6)|p.N239K(6)|p.0?(6)|p.S241del(5)|p.S241T(5)|p.N239T(4)|p.N239_C242delNSSC(3)|p.S240C(3)|p.S241S(3)|p.S241P(3)|p.N239_S240insX(2)|p.N239fs*8(2)|p.S240S(2)|p.S240T(2)|p.S240fs*7(2)|p.N239_S240delNS(2)|p.S241fs*22(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.N239fs*1(1)|p.N239_S240insN(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.N239fs*4(1)|p.S240>CSC(1)|p.C238_M246delCNSSCMGGM(1)|p.S240P(1)|p.S241_C242insX(1)|p.M237_N239delMCN(1)|p.S240fs*23(1)|p.N239fs*26(1)|p.C238fs*21(1)|p.N239N(1)|p.H233fs*6(1)|p.S241fs*7(1)|p.S240fs*26(1)|p.N239*(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241fs*23(1)|p.S241_G245delSCMGG(1)|p.N239fs*0(1)|p.C238_N239insX(1)|p.N239_C242del(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		Pancreas(47;798 1329 9957 10801)		111	p.S241Y(DMS53-Tumor)|p.N239D(SNU475-Tumor)|p.N239D(ST486-Tumor)|p.N239D(HUH6-Tumor)|p.S241Y(KMM1-Tumor)|p.S241Y(KALS1-Tumor)|p.S241C(EVSAT-Tumor)|p.S241C(BFTC909-Tumor)|p.S241Y(HCC78-Tumor)|p.S241Y(ES2-Tumor)|p.S241Y(HCT15-Tumor)|p.S240R(NCIH2023-Tumor)|p.C238fs(SW1417-Tumor)|p.S241F(HEC251-Tumor)	690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.41			19	27				---	---	---	---	capture_indel			In_Frame_Del	DEL	7518283	7518291	16923	17	GGAACTGTT	-	-	35	35	TP53	-	5	5
ACAP3	116983	broad.mit.edu	36	1	1218883	1218883	+	Frame_Shift_Del	DEL	A	-	-			TCGA-06-0238-01	TCGA-06-0238-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:1218883_1218883delA	uc001aeb.1	-	c.2429_2429delT	c.(2428-2430)CTGfs	p.L810fs	ACAP3_uc001ady.1_Frame_Shift_Del_p.L540fs|ACAP3_uc001adz.1_Frame_Shift_Del_p.L735fs|ACAP3_uc001aea.1_Frame_Shift_Del_p.L735fs	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	810					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0														0.33			2	4				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	1218883	1218883	121	1	A	-	-	7	7	ACAP3	-	5	5
UQCRQ	27089	broad.mit.edu	36	5	132230599	132230600	+	Frame_Shift_Ins	INS	-	G	G			TCGA-06-0238-01	TCGA-06-0238-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:132230599_132230600insG	uc003kya.1	+	c.127_128insG	c.(127-129)CGGfs	p.R43fs	GDF9_uc003kxz.1_5'Flank	NM_014402	NP_055217	O14949	QCR8_HUMAN	ubiquinol-cytochrome c reductase, complex III	43					respiratory electron transport chain	mitochondrial inner membrane|respiratory chain	ubiquinol-cytochrome-c reductase activity				0		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)											0.31			30	66				---	---	---	---	capture_indel			Frame_Shift_Ins	INS	132230599	132230600	17585	5	-	G	G	31	31	UQCRQ	G	5	5
UBE2CBP	90025	broad.mit.edu	36	6	83785541	83785541	+	Frame_Shift_Del	DEL	C	-	-			TCGA-06-0238-01	TCGA-06-0238-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:83785541_83785541delC	uc003pjp.1	-	c.880_880delG	c.(880-882)GAAfs	p.E294fs	UBE2CBP_uc003pjq.1_Frame_Shift_Del_p.E84fs	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	294						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)										0.40			46	68				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	83785541	83785541	17404	6	C	-	-	29	29	UBE2CBP	-	5	5
