Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
BLNK	29760	broad.mit.edu	36	10	97946730	97946730	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:97946730C>T	uc001kls.2	-	c.1175G>A	c.(1174-1176)CGA>CAA	p.R392Q	BLNK_uc001kme.2_Missense_Mutation_p.R287Q|BLNK_uc001klt.2_Missense_Mutation_p.R283Q|BLNK_uc009xvc.1_Non-coding_Transcript|BLNK_uc001klu.2_Intron|BLNK_uc001klv.2_Intron|BLNK_uc001klw.2_Intron|BLNK_uc001klx.2_Missense_Mutation_p.R369Q|BLNK_uc001kly.2_Intron|BLNK_uc001klz.2_Non-coding_Transcript|BLNK_uc001kma.2_Intron|BLNK_uc001kmb.2_Missense_Mutation_p.R188Q|BLNK_uc001kmc.2_Intron|BLNK_uc001kmd.2_Missense_Mutation_p.R310Q|BLNK_uc009xvd.1_Non-coding_Transcript	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	392	SH2.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity				0		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)						449				0.75	104.467727	106.739454	30	10	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	97946730	97946730	1472	10	C	T	T	31	31	BLNK	T	1	1
CALCA	796	broad.mit.edu	36	11	14945926	14945926	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:14945926C>T	uc001mlt.1	-	c.278G>A	c.(277-279)CGG>CAG	p.R93Q	CALCA_uc001mlu.1_Non-coding_Transcript	NM_001033953	NP_001029125	P06881	CALCA_HUMAN	calcitonin isoform CGRP preproprotein	93					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytoplasm|extracellular space	hormone activity			central_nervous_system(1)	1					Phentolamine(DB00692)									0.364017	278.773593	282.656029	87	152	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	14945926	14945926	2691	11	C	T	T	23	23	CALCA	T	1	1
SYT13	57586	broad.mit.edu	36	11	45230705	45230705	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:45230705G>A	uc001myq.2	-	c.689C>T	c.(688-690)GCG>GTG	p.A230V	SYT13_uc009yku.1_Missense_Mutation_p.A86V	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	230	Cytoplasmic (Potential).|C2 1.					transport vesicle				ovary(1)	1												OREG0020928	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.458333	62.44134	62.513415	22	26	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	45230705	45230705	15990	11	G	A	A	38	38	SYT13	A	1	1
OR4A15	81328	broad.mit.edu	36	11	54892132	54892132	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:54892132C>T	uc001nhn.1	+	c.197C>T	c.(196-198)ACG>ATG	p.T66M		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	66	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1														0.371859	221.501517	224.370607	74	125	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	54892132	54892132	11446	11	C	T	T	19	19	OR4A15	T	1	1
MS4A6A	64231	broad.mit.edu	36	11	59697109	59697109	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:59697109G>A	uc001nos.2	-	c.703C>T	c.(703-705)CGG>TGG	p.R235W	MS4A6A_uc001noq.1_Missense_Mutation_p.A172V|MS4A6A_uc001nor.1_Missense_Mutation_p.R207W|MS4A6A_uc009ymv.1_Missense_Mutation_p.R207W|MS4A6A_uc001not.1_Missense_Mutation_p.R207W	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	207	Cytoplasmic (Potential).					integral to membrane	receptor activity				0														0.424658	198.119344	198.843367	62	84	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	59697109	59697109	10257	11	G	A	A	38	38	MS4A6A	A	1	1
NADSYN1	55191	broad.mit.edu	36	11	70862360	70862360	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:70862360G>A	uc001oqn.1	+	c.646G>A	c.(646-648)GTG>ATG	p.V216M	NADSYN1_uc001oqm.2_Non-coding_Transcript|NADSYN1_uc001oqo.1_De_novo_Start_OutOfFrame	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	216	CN hydrolase.				NAD biosynthetic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	Ovarian(79;763 1781 6490 50276)								0.526316	62.899334	62.922139	20	18	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70862360	70862360	10534	11	G	A	A	40	40	NADSYN1	A	1	1
TMEM132D	121256	broad.mit.edu	36	12	128750307	128750307	+	Splice_Site_SNP	SNP	C	A	A			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:128750307C>A	uc009zyl.1	-	c.e2_splice_site				NM_133448	NP_597705			transmembrane protein 132D							integral to membrane				ovary(10)|pancreas(2)	12	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)										0.355932	67.60765	68.665191	21	38	CC		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	128750307	128750307	16579	12	C	A	A	18	18	TMEM132D	A	5	3
TMEM132D	121256	broad.mit.edu	36	12	128750694	128750694	+	Silent	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:128750694G>A	uc009zyl.1	-	c.582C>T	c.(580-582)GCC>GCT	p.A194A		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D	194	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)	12	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)										0.5	6.44988	6.44988	2	2	GG		KEEP	---	---	---	---	capture			Silent	SNP	128750694	128750694	16579	12	G	A	A	39	39	TMEM132D	A	1	1
KCNA5	3741	broad.mit.edu	36	12	5025336	5025336	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:5025336G>A	uc001qni.1	+	c.1762G>A	c.(1762-1764)GTC>ATC	p.V588I		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	588						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4														0.25	19.986662	21.803574	8	24	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	5025336	5025336	8311	12	G	A	A	40	40	KCNA5	A	1	1
ERBB3	2065	broad.mit.edu	36	12	54773584	54773584	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:54773584G>A	uc001sjh.1	+	c.1463G>A	c.(1462-1464)CGG>CAG	p.R488Q	ERBB3_uc009zoj.1_Intron|ERBB3_uc001sjj.1_Missense_Mutation_p.R56Q|ERBB3_uc009zok.1_5'Flank|ERBB3_uc001sjk.1_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	488	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|protein phosphorylation|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)							322				0.545455	144.056397	144.194905	42	35	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	54773584	54773584	5401	12	G	A	A	39	39	ERBB3	A	1	1
ZNF384	171017	broad.mit.edu	36	12	6652728	6652728	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:6652728G>A	uc001qpz.1	-	c.826C>T	c.(826-828)CGT>TGT	p.R276C	ZNF384_uc001qqa.1_Missense_Mutation_p.R276C|ZNF384_uc001qqb.1_Missense_Mutation_p.R260C|ZNF384_uc001qqc.1_Missense_Mutation_p.R276C|ZNF384_uc001qqd.1_Missense_Mutation_p.R221C|ZNF384_uc001qqe.1_Missense_Mutation_p.R260C|ZNF384_uc009zew.1_Missense_Mutation_p.R162C	NM_001039916	NP_597733	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform a	276	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8										141				0.38843	141.600532	142.918817	47	74	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	6652728	6652728	18467	12	G	A	A	39	39	ZNF384	A	1	1
ATP12A	479	broad.mit.edu	36	13	24172946	24172946	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr13:24172946C>T	uc010aaa.1	+	c.1785C>T	c.(1783-1785)GAC>GAT	p.D595D	ATP12A_uc001upp.1_Silent_p.D589D	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	589	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	Pancreas(156;1582 1935 18898 22665 26498)								0.829545	515.214598	533.28011	146	30	CC		KEEP	---	---	---	---	capture			Silent	SNP	24172946	24172946	1141	13	C	T	T	19	19	ATP12A	T	1	1
CETP	1071	broad.mit.edu	36	16	55573622	55573622	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:55573622C>T	uc002eki.2	+	c.1293C>T	c.(1291-1293)ACC>ACT	p.T431T	CETP_uc002ekj.2_Silent_p.T371T	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	431					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|reverse cholesterol transport|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)	1														0.381944	171.790098	173.550093	55	89	CC		KEEP	---	---	---	---	capture			Silent	SNP	55573622	55573622	3410	16	C	T	T	23	23	CETP	T	1	1
HYDIN	54768	broad.mit.edu	36	16	69418725	69418725	+	Silent	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:69418725G>A	uc002ezr.1	-	c.14364C>T	c.(14362-14364)GGC>GGT	p.G4788G	HYDIN_uc010cfy.1_Non-coding_Transcript	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4789										ovary(1)	1		Ovarian(137;0.0654)												0.224913	154.510375	174.621884	65	224	GG		KEEP	---	---	---	---	capture			Silent	SNP	69418725	69418725	7767	16	G	A	A	34	34	HYDIN	A	2	2
TAT	6898	broad.mit.edu	36	16	70162160	70162160	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:70162160C>T	uc002fap.2	-	c.835G>A	c.(835-837)GCC>ACC	p.A279T		NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	279					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	Melanoma(198;542 2142 10292 21661 50033)|Esophageal Squamous(48;487 1013 5572 44395 52594)								0.482143	240.62125	240.663824	81	87	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70162160	70162160	16112	16	C	T	T	26	26	TAT	T	2	2
MYH3	4621	broad.mit.edu	36	17	10485359	10485359	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:10485359C>T	uc002gmq.1	-	c.2015G>A	c.(2014-2016)CGT>CAT	p.R672H		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	672	Myosin head-like.|Actin-binding.		R -> H (in DA2A).|R -> C (in DA2A).		muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(1)|pancreas(1)	6														0.45283	78.618086	78.716757	24	29	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	10485359	10485359	10431	17	C	T	T	19	19	MYH3	T	1	1
TP53	7157	broad.mit.edu	36	17	7519280	7519280	+	Splice_Site_SNP	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:7519280C>T	uc002gim.2	-	c.e5_splice_site			TP53_uc002gig.1_Splice_Site_SNP|TP53_uc002gih.1_Splice_Site_SNP|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Splice_Site_SNP|TP53_uc010cni.1_Splice_Site_SNP|TP53_uc002gij.2_Splice_Site_SNP|TP53_uc010cnj.1_Splice_Site_SNP|TP53_uc002gin.2_Splice_Site_SNP|TP53_uc002gio.2_Splice_Site_SNP	NM_001126112	NP_001119584			tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.?(31)|p.0?(6)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		Pancreas(47;798 1329 9957 10801)		111	(F36P-Tumor)|(BICR56-Tumor)|(OVCAR8-Tumor)|(BECKER-Tumor)|(CORL279-Tumor)|(SNU201-Tumor)	690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.421053	23.493901	23.597733	8	11	CC		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	7519280	7519280	16923	17	C	T	T	20	20	TP53	T	5	2
TP53	7157	broad.mit.edu	36	17	7520253	7520253	+	Nonsense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:7520253C>T	uc002gim.2	-	c.159G>A	c.(157-159)TGG>TGA	p.W53*	TP53_uc002gig.1_Nonsense_Mutation_p.W53*|TP53_uc002gih.1_Nonsense_Mutation_p.W53*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.W53*|TP53_uc010cni.1_Nonsense_Mutation_p.W53*|TP53_uc002gij.2_Nonsense_Mutation_p.W53*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010cnk.1_Nonsense_Mutation_p.W68*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	53	TADII.|Interaction with HRMT1L2.		W -> C (in sporadic cancers; somatic mutation).|W -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.W53*(6)|p.0?(6)|p.W53C(2)|p.E51fs*59(1)|p.D48fs*55(1)|p.Q52fs*67(1)|p.W53fs*1(1)|p.F54fs*3(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		Pancreas(47;798 1329 9957 10801)		111		690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.4	220.813247	222.43032	74	111	CC		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	7520253	7520253	16923	17	C	T	T	18	18	TP53	T	5	2
CCDC105	126402	broad.mit.edu	36	19	14992378	14992378	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:14992378C>T	uc002nae.1	+	c.781C>T	c.(781-783)CGC>TGC	p.R261C		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	261					microtubule cytoskeleton organization	microtubule				ovary(1)	1														0.242775	100.267638	110.704271	42	131	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	14992378	14992378	2860	19	C	T	T	19	19	CCDC105	T	1	1
CYP4F8	11283	broad.mit.edu	36	19	15600211	15600211	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:15600211C>T	uc002nbi.1	+	c.1215C>T	c.(1213-1215)GAC>GAT	p.D405D		NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	405					oxidation-reduction process|prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding	p.D404D(1)		large_intestine(1)	1														0.363636	12.10253	12.28014	4	7	CC		KEEP	---	---	---	---	capture			Silent	SNP	15600211	15600211	4356	19	C	T	T	19	19	CYP4F8	T	1	1
ZNF99	7652	broad.mit.edu	36	19	22731138	22731138	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:22731138C>T	uc002nqx.1	-	c.2873G>A	c.(2872-2874)CGC>CAC	p.R958H		NM_001080409	NP_001073878	A8MXY4	ZNF99_HUMAN	zinc finger protein 99	958	C2H2-type 28; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)												0.33	93.236226	95.800224	33	67	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	22731138	22731138	18808	19	C	T	T	27	27	ZNF99	T	1	1
ZNF585A	199704	broad.mit.edu	36	19	42336303	42336303	+	Missense_Mutation	SNP	T	C	C			TCGA-12-1600-01	TCGA-12-1600-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr19:42336303T>C	uc002ofo.1	-	c.338A>G	c.(337-339)TAT>TGT	p.Y113C	ZNF585A_uc002ofm.1_Missense_Mutation_p.Y58C|ZNF585A_uc002ofn.1_Missense_Mutation_p.Y58C	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)											0.305263	716.231204	741.993886	232	528	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	42336303	42336303	18612	19	T	C	C	49	49	ZNF585A	C	4	4
ACTN4	81	broad.mit.edu	36	19	43899660	43899660	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:43899660G>A	uc002oja.1	+	c.1007G>A	c.(1006-1008)CGC>CAC	p.R336H	ACTN4_uc010egc.1_Missense_Mutation_p.R336H	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	336	Spectrin 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			Colon(168;199 1940 10254 46213 46384)								0.307692	30.682884	31.970213	12	27	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	43899660	43899660	208	19	G	A	A	38	38	ACTN4	A	1	1
SLC6A16	28968	broad.mit.edu	36	19	54485361	54485361	+	Missense_Mutation	SNP	C	G	G			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:54485361C>G	uc002pmz.1	-	c.2042G>C	c.(2041-2043)TGC>TCC	p.C681S	SLC6A16_uc002pna.2_3'UTR	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	681	Cytoplasmic (Potential).					integral to plasma membrane|intracellular	neurotransmitter:sodium symporter activity			ovary(1)|kidney(1)	2		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)										0.25	102.905587	111.31306	37	111	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	54485361	54485361	15176	19	C	G	G	25	25	SLC6A16	G	3	3
TNFRSF8	943	broad.mit.edu	36	1	12092768	12092768	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:12092768G>A	uc001atq.1	+	c.596G>A	c.(595-597)CGC>CAC	p.R199H		NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	199	Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)						756				0.515152	51.877401	51.884181	17	16	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	12092768	12092768	16840	1	G	A	A	38	38	TNFRSF8	A	1	1
RORC	6097	broad.mit.edu	36	1	150055818	150055818	+	Nonsense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150055818G>A	uc001ezh.1	-	c.244C>T	c.(244-246)CGA>TGA	p.R82*	RORC_uc001ezg.1_Nonsense_Mutation_p.R61*	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	82	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)											0.545455	37.301861	37.3417	12	10	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	150055818	150055818	14009	1	G	A	A	39	39	RORC	A	5	1
TCHHL1	126637	broad.mit.edu	36	1	150324083	150324083	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150324083C>T	uc001ezo.1	-	c.2699G>A	c.(2698-2700)AGC>AAC	p.S900N		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	900							calcium ion binding			ovary(1)	1	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)											0.397614	610.032416	614.632253	200	303	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	150324083	150324083	16227	1	C	T	T	28	28	TCHHL1	T	2	2
PGLYRP4	57115	broad.mit.edu	36	1	151579600	151579600	+	Silent	SNP	A	G	G			TCGA-12-1600-01	TCGA-12-1600-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr1:151579600A>G	uc001fbo.1	-	c.705T>C	c.(703-705)TAT>TAC	p.Y235Y	PGLYRP4_uc001fbp.1_Silent_p.Y231Y	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta	235					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity			ovary(3)	3	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)											0.39267	227.620036	229.533349	75	116	AA		KEEP	---	---	---	---	capture			Silent	SNP	151579600	151579600	12219	1	A	G	G	8	8	PGLYRP4	G	4	4
PVRL4	81607	broad.mit.edu	36	1	159314056	159314056	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:159314056C>T	uc001fxo.1	-	c.541G>A	c.(541-543)GTG>ATG	p.V181M		NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	181	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			NSCLC(76;1160 1387 14476 16172 29359)								0.487179	59.021546	59.027171	19	20	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	159314056	159314056	13300	1	C	T	T	19	19	PVRL4	T	1	1
C1orf125	126859	broad.mit.edu	36	1	177680781	177680781	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:177680781C>T	uc001gmo.1	+	c.1617C>T	c.(1615-1617)TAC>TAT	p.Y539Y	C1orf125_uc009wxg.1_Intron|C1orf125_uc001gmn.1_Silent_p.Y327Y|C1orf125_uc001gmp.1_Silent_p.Y539Y	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	539											0														0.421801	289.442763	290.567887	89	122	CC		KEEP	---	---	---	---	capture			Silent	SNP	177680781	177680781	2060	1	C	T	T	19	19	C1orf125	T	1	1
UBXN10	127733	broad.mit.edu	36	1	20390076	20390076	+	Silent	SNP	C	A	A			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:20390076C>A	uc001bdb.1	+	c.435C>A	c.(433-435)ATC>ATA	p.I145I	UBXN10_uc009vpr.1_Silent_p.I145I	NM_152376	NP_689589	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	145										ovary(1)	1														0.459677	167.552679	167.72868	57	67	CC		KEEP	---	---	---	---	capture			Silent	SNP	20390076	20390076	17470	1	C	A	A	30	30	UBXN10	A	3	3
UBXN11	91544	broad.mit.edu	36	1	26483324	26483324	+	Splice_Site_SNP	SNP	C	G	G			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:26483324C>G	uc001blw.1	-	c.e13_splice_site			UBXN11_uc001blv.1_Splice_Site_SNP|UBXN11_uc001blx.1_Splice_Site_SNP|UBXN11_uc001bly.1_Splice_Site_SNP|UBXN11_uc001blz.1_Splice_Site_SNP|UBXN11_uc001bma.1_Splice_Site_SNP|UBXN11_uc001bmb.1_Splice_Site_SNP	NM_183008	NP_892120			socius isoform 2							cytoplasm|cytoskeleton				ovary(1)	1														0.375	51.931429	52.591748	18	30	CC		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	26483324	26483324	17471	1	C	G	G	24	24	UBXN11	G	5	3
C20orf79	140856	broad.mit.edu	36	20	18742525	18742525	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:18742525C>T	uc002wrk.1	+	c.66C>T	c.(64-66)TTC>TTT	p.F22F		NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	22							sterol binding				0														0.349398	83.749745	85.410476	29	54	CC		KEEP	---	---	---	---	capture			Silent	SNP	18742525	18742525	2199	20	C	T	T	31	31	C20orf79	T	1	1
PDYN	5173	broad.mit.edu	36	20	1909097	1909097	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:1909097G>A	uc010gaj.1	-	c.637C>T	c.(637-639)CGC>TGC	p.R213C	PDYN_uc002wfv.1_Missense_Mutation_p.R213C	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	213					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			ovary(1)	1														0.277311	86.32615	91.57796	33	86	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	1909097	1909097	12120	20	G	A	A	38	38	PDYN	A	1	1
ZNF831	128611	broad.mit.edu	36	20	57263027	57263027	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:57263027G>A	uc002yan.1	+	c.4868G>A	c.(4867-4869)CGG>CAG	p.R1623Q		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1623						intracellular	nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(29;0.0085)													0.325444	168.471622	173.038062	55	114	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	57263027	57263027	18784	20	G	A	A	39	39	ZNF831	A	1	1
PPP1R3D	5509	broad.mit.edu	36	20	57947609	57947609	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:57947609C>T	uc002ybb.1	-	c.773G>A	c.(772-774)CGC>CAC	p.R258H	C20orf177_uc002yba.1_Intron|C20orf177_uc002ybc.1_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	258	CBM21.				glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)											0.214286	13.099032	15.164124	6	22	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	57947609	57947609	12809	20	C	T	T	27	27	PPP1R3D	T	1	1
LRP2	4036	broad.mit.edu	36	2	169719282	169719282	+	Missense_Mutation	SNP	A	T	T			TCGA-12-1600-01	TCGA-12-1600-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr2:169719282A>T	uc002ues.1	-	c.12229T>A	c.(12229-12231)TAT>AAT	p.Y4077N		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4077	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	23				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)					2055				0.514286	173.75266	173.771429	54	51	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	169719282	169719282	9329	2	A	T	T	14	14	LRP2	T	4	4
PPP1CB	5500	broad.mit.edu	36	2	28855290	28855290	+	Missense_Mutation	SNP	C	G	G			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:28855290C>G	uc002rmg.1	+	c.296C>G	c.(295-297)TCT>TGT	p.S99C	PPP1CB_uc002rmh.1_Missense_Mutation_p.S99C	NM_206876	NP_996759	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta	99					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)													0.217949	40.127528	45.85402	17	61	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	28855290	28855290	12785	2	C	G	G	32	32	PPP1CB	G	3	3
ALK	238	broad.mit.edu	36	2	29351512	29351512	+	Silent	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:29351512G>A	uc002rmy.1	-	c.1998C>T	c.(1996-1998)CCC>CCT	p.P666P		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase	666	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(191)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(14)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(200)|autonomic_ganglia(95)|soft_tissue(59)|kidney(4)|large_intestine(3)|ovary(3)|central_nervous_system(1)|breast(1)|pancreas(1)	1093	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)					777				0.3	54.869323	56.989429	18	42	GG		KEEP	---	---	---	---	capture			Silent	SNP	29351512	29351512	528	2	G	A	A	39	39	ALK	A	1	1
HTRA2	27429	broad.mit.edu	36	2	74613532	74613532	+	Missense_Mutation	SNP	C	G	G			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:74613532C>G	uc002smi.1	+	c.1289C>G	c.(1288-1290)GCT>GGT	p.A430G	HTRA2_uc002smj.1_Missense_Mutation_p.A333G|HTRA2_uc002smk.1_Missense_Mutation_p.A408G|HTRA2_uc002sml.1_Missense_Mutation_p.A398G|HTRA2_uc002smm.1_Missense_Mutation_p.A171G|HTRA2_uc002smn.1_Missense_Mutation_p.A171G|LOXL3_uc002smo.1_3'UTR|LOXL3_uc010ffm.1_3'UTR|LOXL3_uc002smp.1_3'UTR|LOXL3_uc002smq.1_3'UTR	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	430	PDZ.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1														0.300469	178.513374	186.091599	64	149	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	74613532	74613532	7754	2	C	G	G	28	28	HTRA2	G	3	3
ACVR2B	93	broad.mit.edu	36	3	38493791	38493791	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:38493791G>A	uc003cif.1	+	c.62G>A	c.(61-63)CGT>CAT	p.R21H	ACVR2B_uc003cig.1_De_novo_Start_InFrame	NM_001106	NP_001097	Q13705	AVR2B_HUMAN	activin A type IIB receptor precursor	21	Extracellular (Potential).				activin receptor signaling pathway|anterior/posterior pattern formation|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|protein phosphorylation|regulation of transcription, DNA-dependent	cell surface|cytoplasm|integral to plasma membrane	activin receptor activity|ATP binding|growth factor binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			lung(1)	1	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0565)|Kidney(284;0.071)						107				0.333333	11.896801	12.191608	4	8	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	38493791	38493791	225	3	G	A	A	40	40	ACVR2B	A	1	1
RPL14	9045	broad.mit.edu	36	3	40474439	40474439	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:40474439C>T	uc003ckg.1	+	c.58C>T	c.(58-60)CAT>TAT	p.H20Y	RPL14_uc003ckh.1_Missense_Mutation_p.H20Y|RPL14_uc003cki.1_5'UTR	NM_003973	NP_003964	P50914	RL14_HUMAN	ribosomal protein L14	20					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)										0.439189	204.052258	204.529611	65	83	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	40474439	40474439	14040	3	C	T	T	29	29	RPL14	T	2	2
ENPEP	2028	broad.mit.edu	36	4	111660919	111660919	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:111660919C>T	uc003iab.2	+	c.1675C>T	c.(1675-1677)CGC>TGC	p.R559C		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	559	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)									0.420561	280.85158	282.019439	90	124	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	111660919	111660919	5321	4	C	T	T	19	19	ENPEP	T	1	1
GRXCR1	389207	broad.mit.edu	36	4	42659694	42659694	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:42659694G>A	uc003gwt.1	+	c.413G>A	c.(412-414)CGT>CAT	p.R138H		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	138	Glutaredoxin.		R -> C (in DFNB25).		cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1														0.40303	424.202814	426.916787	133	197	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	42659694	42659694	7092	4	G	A	A	40	40	GRXCR1	A	1	1
AQPEP	206338	broad.mit.edu	36	5	115326744	115326744	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:115326744C>T	uc003kro.1	+	c.531C>T	c.(529-531)GAC>GAT	p.D177D	AQPEP_uc003krp.1_Non-coding_Transcript	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	177	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0														0.581395	73.673907	73.921654	25	18	CC		KEEP	---	---	---	---	capture			Silent	SNP	115326744	115326744	845	5	C	T	T	19	19	AQPEP	T	1	1
SLC6A3	6531	broad.mit.edu	36	5	1447870	1447870	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:1447870G>A	uc003jck.2	-	c.1843C>T	c.(1843-1845)CGC>TGC	p.R615C		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	615	Cytoplasmic (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)									0.342857	115.871424	118.160576	36	69	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	1447870	1447870	15182	5	G	A	A	39	39	SLC6A3	A	1	1
HCN1	348980	broad.mit.edu	36	5	45298350	45298350	+	Silent	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:45298350G>A	uc003jok.1	-	c.2103C>T	c.(2101-2103)ACC>ACT	p.T701T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	701	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1														0.538462	65.474058	65.524155	21	18	GG		KEEP	---	---	---	---	capture			Silent	SNP	45298350	45298350	7278	5	G	A	A	39	39	HCN1	A	1	1
SIM1	6492	broad.mit.edu	36	6	100948258	100948258	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:100948258C>T	uc003pqj.2	-	c.1396G>A	c.(1396-1398)GCC>ACC	p.A466T	SIM1_uc010kct.1_Missense_Mutation_p.A466T|SIM1_uc010kcu.1_Missense_Mutation_p.A466T	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	466	Single-minded C-terminal.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)										0.391304	74.944204	75.64494	27	42	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	100948258	100948258	14818	6	C	T	T	26	26	SIM1	T	2	2
MOXD1	26002	broad.mit.edu	36	6	132691325	132691325	+	Silent	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:132691325G>A	uc003qdf.1	-	c.765C>T	c.(763-765)CAC>CAT	p.H255H	MOXD1_uc003qde.1_Silent_p.H187H	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	255	Lumenal (Potential).				catecholamine metabolic process|oxidation-reduction process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)										0.375839	172.364667	174.380299	56	93	GG		KEEP	---	---	---	---	capture			Silent	SNP	132691325	132691325	10112	6	G	A	A	40	40	MOXD1	A	1	1
NMBR	4829	broad.mit.edu	36	6	142451168	142451168	+	Silent	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:142451168G>A	uc003qiu.1	-	c.321C>T	c.(319-321)GAC>GAT	p.D107D		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	107	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)	3	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)										0.362069	121.836326	123.770664	42	74	GG		KEEP	---	---	---	---	capture			Silent	SNP	142451168	142451168	10890	6	G	A	A	40	40	NMBR	A	1	1
ZNF184	7738	broad.mit.edu	36	6	27527087	27527087	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:27527087G>A	uc003nji.1	-	c.2230C>T	c.(2230-2232)CAT>TAT	p.H744Y	ZNF184_uc003njj.1_Missense_Mutation_p.H744Y|ZNF184_uc010jqv.1_Missense_Mutation_p.H744Y	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	744	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1														0.39777	333.260329	335.722696	107	162	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	27527087	27527087	18342	6	G	A	A	48	48	ZNF184	A	2	2
BRD2	6046	broad.mit.edu	36	6	33051151	33051151	+	Missense_Mutation	SNP	A	G	G			TCGA-12-1600-01	TCGA-12-1600-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr6:33051151A>G	uc010juh.1	+	c.346A>G	c.(346-348)ATT>GTT	p.I116V	BRD2_uc003ocn.2_Missense_Mutation_p.I116V|BRD2_uc003oco.2_Non-coding_Transcript|BRD2_uc003ocq.2_Missense_Mutation_p.I116V|BRD2_uc003ocp.2_5'UTR	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	116	Bromo 1.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5										227				0.390625	78.46437	79.133515	25	39	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	33051151	33051151	1533	6	A	G	G	4	4	BRD2	G	4	4
GPR115	221393	broad.mit.edu	36	6	47790460	47790460	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:47790460G>A	uc003oyz.1	+	c.1691G>A	c.(1690-1692)CGT>CAT	p.R564H	GPR115_uc003oza.1_Missense_Mutation_p.R507H|GPR115_uc003ozb.1_Missense_Mutation_p.R507H	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115	507	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|breast(1)	4						GBM(22;431 510 9010 26644 32828)								0.422619	450.705427	452.457342	142	194	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	47790460	47790460	6906	6	G	A	A	40	40	GPR115	A	1	1
CD109	135228	broad.mit.edu	36	6	74538010	74538010	+	Silent	SNP	T	C	C			TCGA-12-1600-01	TCGA-12-1600-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr6:74538010T>C	uc003php.1	+	c.1812T>C	c.(1810-1812)GAT>GAC	p.D604D	CD109_uc010kaz.1_Silent_p.D604D|CD109_uc003phq.1_Silent_p.D604D|CD109_uc010kba.1_Silent_p.D527D	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109	604	Bait region (approximate) (By similarity).					anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4														0.462264	687.774322	688.298565	196	228	TT		KEEP	---	---	---	---	capture			Silent	SNP	74538010	74538010	3090	6	T	C	C	49	49	CD109	C	4	4
FLNC	2318	broad.mit.edu	36	7	128274161	128274161	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:128274161C>T	uc003vnz.2	+	c.4254C>T	c.(4252-4254)GAC>GAT	p.D1418D	FLNC_uc003voa.2_Silent_p.D1418D	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1418	Filamin 12.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)	10										892				0.296296	109.140909	114.155617	40	95	CC		KEEP	---	---	---	---	capture			Silent	SNP	128274161	128274161	6177	7	C	T	T	19	19	FLNC	T	1	1
EGFR	1956	broad.mit.edu	36	7	55216516	55216516	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:55216516G>A	uc003tqk.1	+	c.2320G>A	c.(2320-2322)GTG>ATG	p.V774M	EGFR_uc010kzg.1_Missense_Mutation_p.V729M	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	774	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.H773_V774insNPH(11)|p.H773_V774insH(3)|p.V774M(3)|p.H773_V774insPH(2)|p.H773_V774insGH(1)|p.H773_V774insG(1)|p.G729R(1)|p.H773_V774>LM(1)|p.V774L(1)|p.V774_C775insHV(1)|p.H773_V774insGNPH(1)|p.V774del(1)|p.G729E(1)		lung(8200)|central_nervous_system(103)|upper_aerodigestive_tract(37)|prostate(32)|ovary(31)|thyroid(23)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|stomach(6)|urinary_tract(6)|skin(5)|adrenal_gland(5)|kidney(4)|soft_tissue(4)|bone(3)|NS(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)|pancreas(1)	8515	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)			8		608	TCGA GBM(3;<1E-8)|TSP Lung(4;<1E-8)			0.492537	1213.832665	1213.869073	396	408	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55216516	55216516	5156	7	G	A	A	40	40	EGFR	A	1	1
CACNA2D1	781	broad.mit.edu	36	7	81432884	81432884	+	Missense_Mutation	SNP	A	G	G			TCGA-12-1600-01	TCGA-12-1600-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:81432884A>G	uc003uhr.1	-	c.2536T>C	c.(2536-2538)TTT>CTT	p.F846L		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	858	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)									0.246835	209.695629	228.23814	78	238	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	81432884	81432884	2664	7	A	G	G	2	2	CACNA2D1	G	4	4
COL14A1	7373	broad.mit.edu	36	8	121359979	121359979	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:121359979C>T	uc003yox.1	+	c.3462C>T	c.(3460-3462)TCC>TCT	p.S1154S	COL14A1_uc003yoz.2_Silent_p.S119S	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1154	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)							1131				0.472	193.314187	193.399629	59	66	CC		KEEP	---	---	---	---	capture			Silent	SNP	121359979	121359979	3809	8	C	T	T	21	21	COL14A1	T	2	2
MAPK15	225689	broad.mit.edu	36	8	144875735	144875735	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:144875735C>T	uc003yzj.1	+	c.1233C>T	c.(1231-1233)CCC>CCT	p.P411P		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	411					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)							103				0.583333	20.82486	20.897316	7	5	CC		KEEP	---	---	---	---	capture			Silent	SNP	144875735	144875735	9660	8	C	T	T	21	21	MAPK15	T	2	2
FGL1	2267	broad.mit.edu	36	8	17770757	17770757	+	Missense_Mutation	SNP	T	G	G			TCGA-12-1600-01	TCGA-12-1600-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr8:17770757T>G	uc003wye.1	-	c.689A>C	c.(688-690)GAA>GCA	p.E230A	FGL1_uc003wxx.1_Missense_Mutation_p.E180A|FGL1_uc003wxy.1_Missense_Mutation_p.E180A|FGL1_uc003wxz.1_Missense_Mutation_p.E179A|FGL1_uc003wya.1_Missense_Mutation_p.E180A|FGL1_uc003wyb.1_Missense_Mutation_p.E180A|FGL1_uc003wyc.1_Missense_Mutation_p.E180A|FGL1_uc003wyd.1_Non-coding_Transcript|FGL1_uc003wyf.1_Missense_Mutation_p.E150A	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	180	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)										0.358974	44.738123	45.42155	14	25	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	17770757	17770757	6109	8	T	G	G	62	62	FGL1	G	4	4
SFRP1	6422	broad.mit.edu	36	8	41285622	41285622	+	Missense_Mutation	SNP	C	A	A			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:41285622C>A	uc003xnt.1	-	c.214G>T	c.(214-216)GGC>TGC	p.G72C		NM_003012	NP_003003	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	72	FZ.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of gene-specific transcription|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of gene-specific transcription|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|regulation of angiogenesis|regulation of cell cycle process|regulation of gene-specific transcription from RNA polymerase II promoter|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|specific transcriptional repressor activity|transcription activator activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)											0.37037	27.912731	28.322248	10	17	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	41285622	41285622	14650	8	C	A	A	22	22	SFRP1	A	3	3
IKBKB	3551	broad.mit.edu	36	8	42293573	42293573	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:42293573C>T	uc003xow.1	+	c.1119C>T	c.(1117-1119)GAC>GAT	p.D373D	IKBKB_uc003xov.2_Silent_p.D373D|IKBKB_uc010lxh.1_Silent_p.D268D|IKBKB_uc003xox.1_Silent_p.D94D|IKBKB_uc010lxi.1_Non-coding_Transcript|IKBKB_uc010lxj.1_Silent_p.D150D	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene	373					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein phosphorylation|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity|transcription activator activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)				p.D373D(ZR7530-Tumor)|p.D373D(NCIH2110-Tumor)	402				0.5	69.77673	69.77673	21	21	CC		KEEP	---	---	---	---	capture			Silent	SNP	42293573	42293573	7912	8	C	T	T	19	19	IKBKB	T	1	1
RNF183	138065	broad.mit.edu	36	9	115099967	115099967	+	Missense_Mutation	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:115099967G>A	uc004bgz.1	-	c.319C>T	c.(319-321)CGC>TGC	p.R107C	RNF183_uc004bha.1_Missense_Mutation_p.R107C|RNF183_uc010muv.1_Missense_Mutation_p.R107C	NM_145051	NP_659488	Q96D59	RN183_HUMAN	ring finger protein 183	107						integral to membrane	zinc ion binding				0														0.8125	41.87978	43.341107	13	3	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	115099967	115099967	13944	9	G	A	A	39	39	RNF183	A	1	1
C5	727	broad.mit.edu	36	9	122816129	122816129	+	Silent	SNP	G	A	A			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:122816129G>A	uc004bkv.1	-	c.2100C>T	c.(2098-2100)TAC>TAT	p.Y700Y	C5_uc010mvm.1_Silent_p.Y700Y	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	700	Anaphylatoxin-like.				activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)									0.350515	101.021679	102.933449	34	63	GG		KEEP	---	---	---	---	capture			Silent	SNP	122816129	122816129	2378	9	G	A	A	40	40	C5	A	1	1
PLAA	9373	broad.mit.edu	36	9	26916558	26916558	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:26916558C>T	uc003zqd.1	-	c.566G>A	c.(565-567)GGG>GAG	p.G189E	PLAA_uc003zqe.1_Missense_Mutation_p.G189E	NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	189					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		Melanoma(175;2670 2735 14091 35526)								0.48	40.499935	40.508563	12	13	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	26916558	26916558	12437	9	C	T	T	22	22	PLAA	T	2	2
DDX58	23586	broad.mit.edu	36	9	32447232	32447232	+	Missense_Mutation	SNP	A	G	G			TCGA-12-1600-01	TCGA-12-1600-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr9:32447232A>G	uc003zra.1	-	c.2666T>C	c.(2665-2667)ATT>ACT	p.I889T	DDX58_uc010mjj.1_Non-coding_Transcript|DDX58_uc010mji.1_Missense_Mutation_p.I818T	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	889	Repressor domain.				innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|response to virus	cytosol	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)										0.422311	341.372045	342.676924	106	145	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	32447232	32447232	4546	9	A	G	G	4	4	DDX58	G	4	4
FAM189A2	9413	broad.mit.edu	36	9	71196449	71196449	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:71196449C>T	uc010mon.1	+	c.1262C>T	c.(1261-1263)GCG>GTG	p.A421V	FAM189A2_uc004ahg.2_Missense_Mutation_p.A421V|FAM189A2_uc010moo.1_Silent_p.S158S	NM_001127608	NP_001121080	Q15884	F1892_HUMAN	chromosome 9 open reading frame 61	421						integral to membrane					0														0.631579	34.292698	34.579829	12	7	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	71196449	71196449	5727	9	C	T	T	27	27	FAM189A2	T	1	1
UBE2NL	389898	broad.mit.edu	36	X	142795001	142795001	+	Missense_Mutation	SNP	G	T	T			TCGA-12-1600-01	TCGA-12-1600-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:142795001G>T	uc004fca.1	+	c.133G>T	c.(133-135)GAT>TAT	p.D45Y		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	45					post-translational protein modification		acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)													0.859155	195.702277	204.533059	61	10	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	142795001	142795001	17424	23	G	T	T	41	41	UBE2NL	T	3	3
MAMLD1	10046	broad.mit.edu	36	X	149389843	149389843	+	Missense_Mutation	SNP	T	C	C			TCGA-12-1600-01	TCGA-12-1600-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chrX:149389843T>C	uc004fee.1	+	c.1340T>C	c.(1339-1341)CTG>CCG	p.L447P		NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	447					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)													0.658824	188.313445	190.205141	56	29	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	149389843	149389843	9591	23	T	C	C	55	55	MAMLD1	C	4	4
IQSEC2	23096	broad.mit.edu	36	X	53301961	53301961	+	Missense_Mutation	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:53301961C>T	uc004dsd.1	-	c.745G>A	c.(745-747)GGT>AGT	p.G249S	IQSEC2_uc004dsc.1_Missense_Mutation_p.G44S	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	239					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3														0.95	69.296752	71.735857	19	1	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	53301961	53301961	8121	23	C	T	T	22	22	IQSEC2	T	2	2
PCDH11Y	83259	broad.mit.edu	36	Y	5665767	5665767	+	Silent	SNP	C	T	T			TCGA-12-1600-01	TCGA-12-1600-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrY:5665767C>T	uc004fqo.1	+	c.3807C>T	c.(3805-3807)GTC>GTT	p.V1269V		NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	1269	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0														0.933333	334.571221	352.244744	98	7	CC		KEEP	---	---	---	---	capture			Silent	SNP	5665767	5665767	11929	24	C	T	T	29	29	PCDH11Y	T	2	2
RB1	5925	broad.mit.edu	36	13	47839639	47839642	+	Frame_Shift_Del	DEL	TCTT	-	-			TCGA-12-1600-01	TCGA-12-1600-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:47839639_47839642delTCTT	uc001vcb.1	+	c.948_951delTCTT	c.(946-951)AATCTTfs	p.N316fs	RB1_uc010act.1_Frame_Shift_Del_p.N17fs	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	316_317					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|transcription repressor activity|ubiquitin protein ligase binding	p.0?(13)		lung(93)|eye(89)|central_nervous_system(47)|bone(22)|breast(20)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|soft_tissue(8)|prostate(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	355		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)			6		568	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0.89			62	8				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	47839639	47839642	13559	13	TCTT	-	-	50	50	RB1	-	5	5
