Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
COL17A1	1308	broad.mit.edu	37	10	105807838	105807838	+	Missense_Mutation	SNP	T	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:105807838T>A	uc001kxr.2	-	c.2252A>T	c.(2251-2253)CAA>CTA	p.Q751L		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	751	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane				ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)										0.309148	273.238163	283.523744	98	219	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	105807838	105807838	3812	10	T	A	A	A	819	63	COL17A1	3	3
MMP1	4312	broad.mit.edu	37	11	102661456	102661457	+	Missense_Mutation	DNP	AA	TT	TT			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:102661456_102661457AA>TT	uc001phi.2	-	c.1277_1278TT>AA	c.(1276-1278)GTT>GAA	p.V426E	MMP1_uc010ruv.1_Missense_Mutation_p.V360E	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	426	Hemopexin-like 4.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)					p.V426V(MKN74-Tumor)	227				0.363636	77.983554	79.062809	24	42	KEEP	---	---	---	---	capture		Missense_Mutation	DNP	102661456	102661457	10038	11	AA	TT	TT	TT	54	5	MMP1	3	3
OR8D4	338662	broad.mit.edu	37	11	123777693	123777693	+	Missense_Mutation	SNP	T	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:123777693T>G	uc010saa.1	+	c.555T>G	c.(553-555)ATT>ATG	p.I185M		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)										0.386667	193.521584	195.208111	58	92	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	123777693	123777693	11644	11	T	G	G	G	783	61	OR8D4	4	4
PLEKHA7	144100	broad.mit.edu	37	11	16838657	16838657	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:16838657G>T	uc010rcu.1	-	c.1556C>A	c.(1555-1557)ACC>AAC	p.T519N	PLEKHA7_uc001mmo.2_Missense_Mutation_p.T519N|PLEKHA7_uc010rcv.1_Missense_Mutation_p.T93N|PLEKHA7_uc001mmn.2_Missense_Mutation_p.T227N	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	519					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(1)	1														0.273973	49.667975	53.028392	20	53	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	16838657	16838657	12487	11	G	T	T	T	572	44	PLEKHA7	2	2
OR10A6	390093	broad.mit.edu	37	11	7949666	7949666	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:7949666G>T	uc010rbh.1	-	c.544C>A	c.(544-546)CCA>ACA	p.P182T		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)										0.235849	60.715819	67.483771	25	81	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	7949666	7949666	11300	11	G	T	T	T	559	43	OR10A6	2	2
SDS	10993	broad.mit.edu	37	12	113831717	113831717	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:113831717G>T	uc001tvg.2	-	c.758C>A	c.(757-759)GCC>GAC	p.A253D		NM_006843	NP_006834	P20132	SDHL_HUMAN	serine dehydratase	253					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			pancreas(1)	1					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)									0.311688	63.968308	66.401632	24	53	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	113831717	113831717	14461	12	G	T	T	T	546	42	SDS	2	2
SLC15A4	121260	broad.mit.edu	37	12	129299352	129299352	+	Silent	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:129299352G>A	uc001uhu.2	-	c.810C>T	c.(808-810)TCC>TCT	p.S270S	SLC15A4_uc001uhv.2_Non-coding_Transcript|MGC16384_uc001uhw.2_5'Flank	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	270					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)										0.26087	50.517435	54.08927	18	51	KEEP	---	---	---	---	capture		Silent	SNP	129299352	129299352	14896	12	G	A	A	A	548	43	SLC15A4	2	2
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:25398285C>A	uc001rgp.1	-	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_Non-coding_Transcript	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(2374)|p.G12S(1078)|p.G12R(674)|p.G12?(50)|p.G12F(33)|p.G12D(15)|p.G12N(6)|p.G12V(6)|p.G12L(5)|p.G12I(3)|p.G12W(3)|p.G12A(2)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12_G13insG(1)		large_intestine(11742)|pancreas(3256)|lung(2694)|biliary_tract(514)|ovary(437)|endometrium(339)|haematopoietic_and_lymphoid_tissue(303)|stomach(179)|thyroid(145)|prostate(85)|soft_tissue(75)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|breast(27)|liver(21)|testis(17)|oesophagus(15)|central_nervous_system(8)|peritoneum(5)|kidney(5)|salivary_gland(5)|thymus(5)|eye(4)|gastrointestinal_tract_(site_indeterminate)(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	20148	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	p.G12R(PSN1-Tumor)|p.G12C(NCIH1373-Tumor)|p.G12C(NCIH1792-Tumor)|p.G12S(KMS20-Tumor)|p.G12C(HCC44-Tumor)|p.G12C(HCC1171-Tumor)|p.G12C(SW837-Tumor)|p.G12C(LU65-Tumor)|p.G12R(HUPT3-Tumor)|p.G12S(A549-Tumor)|p.G12C(NCIH2122-Tumor)|p.G12R(KP2-Tumor)|p.G12C(OV56-Tumor)|p.G12C(IALM-Tumor)|p.G12C(SW1463-Tumor)|p.G12C(SW1573-Tumor)|p.G12R(NCIH1339-Tumor)|p.G12C(NCIH23-Tumor)|p.G12C(MIAPACA2-Tumor)|p.G12C(CALU1-Tumor)|p.G12C(NCIH2030-Tumor)|p.G12S(LS123-Tumor)|p.G12C(KYSE410-Tumor)|p.G12C(UMUC3-Tumor)|p.G12C(NCIH2291-Tumor)|p.G12R(TCCPAN2-Tumor)|p.G12C(KHM1B-Tumor)|p.G12C(LU99-Tumor)|p.G12C(NCIH358-Tumor)|p.G12C(NCIH1385-Tumor)|p.G12R(CAL62-Tumor)	262	TSP Lung(1;<1E-8)|Multiple Myeloma(2;<1E-6)			0.411765	21.721729	21.837389	7	10	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	25398285	25398285	8753	12	C	A	A	A	273	21	KRAS	2	2
CACNA1C	775	broad.mit.edu	37	12	2602398	2602398	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:2602398C>T	uc009zdu.1	+	c.959C>T	c.(958-960)ACG>ATG	p.T320M	CACNA1C_uc009zdv.1_Missense_Mutation_p.T317M|CACNA1C_uc001qkb.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkc.2_Missense_Mutation_p.T320M|CACNA1C_uc001qke.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkf.2_Missense_Mutation_p.T320M|CACNA1C_uc001qjz.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkd.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkg.2_Missense_Mutation_p.T320M|CACNA1C_uc009zdw.1_Missense_Mutation_p.T320M|CACNA1C_uc001qkh.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkl.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkn.2_Missense_Mutation_p.T320M|CACNA1C_uc001qko.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkp.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkr.2_Missense_Mutation_p.T320M|CACNA1C_uc001qku.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkq.2_Missense_Mutation_p.T320M|CACNA1C_uc001qks.2_Missense_Mutation_p.T320M|CACNA1C_uc001qkt.2_Missense_Mutation_p.T320M|CACNA1C_uc001qka.1_De_novo_Start_OutOfFrame|CACNA1C_uc001qki.1_Missense_Mutation_p.T56M|CACNA1C_uc001qkj.1_Missense_Mutation_p.T56M|CACNA1C_uc001qkk.1_Missense_Mutation_p.T56M|CACNA1C_uc001qkm.1_Missense_Mutation_p.T56M	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	320	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)									0.233696	101.130425	113.074222	43	141	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	2602398	2602398	2656	12	C	T	T	T	247	19	CACNA1C	1	1
KCNA6	3742	broad.mit.edu	37	12	4920770	4920770	+	Silent	SNP	A	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:4920770A>T	uc001qng.2	+	c.1563A>T	c.(1561-1563)GCA>GCT	p.A521A		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	521						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|skin(1)	2														0.24	47.711546	52.339525	18	57	KEEP	---	---	---	---	capture		Silent	SNP	4920770	4920770	8312	12	A	T	T	T	80	7	KCNA6	3	3
MBD6	114785	broad.mit.edu	37	12	57920532	57920532	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:57920532C>T	uc001soj.1	+	c.1604C>T	c.(1603-1605)CCT>CTT	p.P535L	MBD6_uc001sok.1_Missense_Mutation_p.P402L|MBD6_uc001sol.1_Non-coding_Transcript	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	535	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4														0.238095	13.764966	15.080257	5	16	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57920532	57920532	9736	12	C	T	T	T	312	24	MBD6	2	2
NAV3	89795	broad.mit.edu	37	12	78582417	78582417	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:78582417C>T	uc001syp.2	+	c.5915C>T	c.(5914-5916)ACT>ATT	p.T1972I	NAV3_uc001syo.2_Missense_Mutation_p.T1950I|NAV3_uc010sub.1_Missense_Mutation_p.T1429I|NAV3_uc009zsf.2_Missense_Mutation_p.T781I	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1972						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|kidney(1)|pancreas(1)	16										1091				0.261194	92.966528	99.880789	35	99	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	78582417	78582417	10581	12	C	T	T	T	260	20	NAV3	2	2
A2M	2	broad.mit.edu	37	12	9243996	9243996	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:9243996G>A	uc001qvk.1	-	c.2270C>T	c.(2269-2271)ACA>ATA	p.T757I	A2M_uc009zgk.1_Missense_Mutation_p.T607I	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	757					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)	4					Bacitracin(DB00626)|Becaplermin(DB00102)									0.208333	67.151535	80.386947	35	133	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	9243996	9243996	5	12	G	A	A	A	624	48	A2M	2	2
NALCN	259232	broad.mit.edu	37	13	101944670	101944670	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:101944670C>A	uc001vox.1	-	c.847G>T	c.(847-849)GTG>TTG	p.V283L	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.V283L|NALCN_uc001vpa.2_Missense_Mutation_p.V283L	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	283	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)													0.395833	54.813883	55.269932	19	29	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	101944670	101944670	10544	13	C	A	A	A	234	18	NALCN	2	2
LATS2	26524	broad.mit.edu	37	13	21549230	21549230	+	Missense_Mutation	SNP	C	T	T	rs113238499		TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:21549230C>T	uc009zzs.2	-	c.3046G>A	c.(3046-3048)GAA>AAA	p.E1016K	LATS2_uc001unr.3_Missense_Mutation_p.E1016K	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	1016	AGC-kinase C-terminal.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|protein phosphorylation	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.E1016K(1)		lung(3)|central_nervous_system(3)|ovary(2)|pancreas(1)	9		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)						174				0.37037	61.788097	62.584667	20	34	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	21549230	21549230	8970	13	C	T	T	T	403	31	LATS2	1	1
OR4N2	390429	broad.mit.edu	37	14	20295636	20295636	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:20295636G>C	uc010tkv.1	+	c.29G>C	c.(28-30)AGA>ACA	p.R10T		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)										0.063241	-9.595364	40.634043	16	237	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20295636	20295636	11487	14	G	C	C	C	429	33	OR4N2	3	3
OXA1L	5018	broad.mit.edu	37	14	23239013	23239013	+	Silent	SNP	C	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:23239013C>G	uc001wgn.2	+	c.633C>G	c.(631-633)GCC>GCG	p.A211A	OXA1L_uc001wgo.2_Non-coding_Transcript|OXA1L_uc010akc.2_Silent_p.A211A|OXA1L_uc001wgp.2_Silent_p.A135A|OXA1L_uc001wgq.2_5'UTR	NM_005015	NP_005006	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	151	Helical; (Potential).				aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex				central_nervous_system(1)	1	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)										0.051685	-54.366552	40.321142	23	422	KEEP	---	---	---	---	capture		Silent	SNP	23239013	23239013	11741	14	C	G	G	G	275	22	OXA1L	3	3
IRF9	10379	broad.mit.edu	37	14	24632300	24632300	+	Silent	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:24632300C>T	uc001wmq.2	+	c.306C>T	c.(304-306)CGC>CGT	p.R102R	RNF31_uc001wmp.2_Non-coding_Transcript|IRF9_uc010alj.2_5'UTR	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	102	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|regulation of transcription, DNA-dependent|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)										0.38961	85.045164	85.862452	30	47	KEEP	---	---	---	---	capture		Silent	SNP	24632300	24632300	8140	14	C	T	T	T	314	25	IRF9	2	2
PAPOLA	10914	broad.mit.edu	37	14	96993836	96993836	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:96993836A>G	uc001yfq.2	+	c.401A>G	c.(400-402)TAT>TGT	p.Y134C	PAPOLA_uc001yfo.2_Missense_Mutation_p.Y134C|PAPOLA_uc001yfp.2_Missense_Mutation_p.Y134C|PAPOLA_uc001yfr.2_Missense_Mutation_p.Y134C|PAPOLA_uc010twv.1_Missense_Mutation_p.Y134C|PAPOLA_uc010avp.2_Intron	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	134					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		NSCLC(19;254 734 11908 35501 39234)								0.5	25.025743	25.025743	7	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	96993836	96993836	11846	14	A	G	G	G	208	16	PAPOLA	4	4
ATP10A	57194	broad.mit.edu	37	15	25959177	25959177	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:25959177G>A	uc010ayu.2	-	c.1988C>T	c.(1987-1989)TCG>TTG	p.S663L		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	663	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)						877				0.461538	16.638431	16.655971	6	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	25959177	25959177	1135	15	G	A	A	A	481	37	ATP10A	1	1
TGM7	116179	broad.mit.edu	37	15	43577065	43577065	+	Silent	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:43577065C>A	uc001zrf.1	-	c.951G>T	c.(949-951)ACG>ACT	p.T317T		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	317					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)									0.276316	60.947051	64.366904	21	55	KEEP	---	---	---	---	capture		Silent	SNP	43577065	43577065	16363	15	C	A	A	A	236	19	TGM7	1	1
TMC3	342125	broad.mit.edu	37	15	81664999	81664999	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:81664999G>T	uc002bgo.1	-	c.169C>A	c.(169-171)CAG>AAG	p.Q57K	TMC3_uc010blr.1_Non-coding_Transcript|TMC3_uc002bgp.2_Missense_Mutation_p.Q57K	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	57	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2														0.234375	77.095957	85.351097	30	98	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	81664999	81664999	16516	15	G	T	T	T	611	47	TMC3	2	2
N4BP1	9683	broad.mit.edu	37	16	48576829	48576829	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:48576829T>C	uc002efp.2	-	c.2677A>G	c.(2677-2679)ATG>GTG	p.M893V		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	893					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)												0.394737	133.045678	134.15231	45	69	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	48576829	48576829	10504	16	T	C	C	C	663	51	N4BP1	4	4
THAP11	57215	broad.mit.edu	37	16	67876864	67876864	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:67876864C>T	uc002euo.2	+	c.407C>T	c.(406-408)TCT>TTT	p.S136F	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	136	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)										0.380952	24.294868	24.555982	8	13	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	67876864	67876864	16371	16	C	T	T	T	416	32	THAP11	2	2
MTSS1L	92154	broad.mit.edu	37	16	70697927	70697927	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:70697927C>A	uc002ezj.2	-	c.1897G>T	c.(1897-1899)GCC>TCC	p.A633S		NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	633					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1														0.666667	6.65439	6.724931	2	1	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	70697927	70697927	10356	16	C	A	A	A	338	26	MTSS1L	2	2
TAOK1	57551	broad.mit.edu	37	17	27805322	27805322	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:27805322C>T	uc002hdz.1	+	c.406C>T	c.(406-408)CTT>TTT	p.L136F	TAOK1_uc010wbe.1_Missense_Mutation_p.L136F|TAOK1_uc010wbf.1_Missense_Mutation_p.L136F|TAOK1_uc002heb.1_5'Flank	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	136	Protein kinase.				mitotic prometaphase|protein phosphorylation	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)							290				0.186047	18.373075	22.345879	8	35	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	27805322	27805322	16068	17	C	T	T	T	416	32	TAOK1	2	2
ARHGAP27	201176	broad.mit.edu	37	17	43474364	43474364	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:43474364G>C	uc002iix.2	-	c.846C>G	c.(844-846)AGC>AGG	p.S282R	ARHGAP27_uc010dak.2_Missense_Mutation_p.S255R	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	623					positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)													0.226667	45.738237	50.880214	17	58	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43474364	43474364	888	17	G	C	C	C	490	38	ARHGAP27	3	3
GIP	2695	broad.mit.edu	37	17	47038345	47038345	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:47038345G>C	uc002iol.1	-	c.355C>G	c.(355-357)CCA>GCA	p.P119A		NM_004123	NP_004114	P09681	GIP_HUMAN	gastric inhibitory polypeptide preproprotein	119					energy reserve metabolic process|signal transduction	extracellular region|soluble fraction	hormone activity				0														0.285714	9.692848	10.270698	4	10	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	47038345	47038345	6659	17	G	C	C	C	559	43	GIP	3	3
SCPEP1	59342	broad.mit.edu	37	17	55058573	55058573	+	Silent	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:55058573C>A	uc002iuv.3	+	c.207C>A	c.(205-207)CCC>CCA	p.P69P	SCPEP1_uc010dcl.2_Non-coding_Transcript|SCPEP1_uc010wnk.1_Silent_p.P19P	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	69					proteolysis	extracellular region	serine-type carboxypeptidase activity				0	Breast(9;2.86e-08)													0.136364	4.909741	7.726621	3	19	KEEP	---	---	---	---	capture		Silent	SNP	55058573	55058573	14417	17	C	A	A	A	275	22	SCPEP1	2	2
POLG2	11232	broad.mit.edu	37	17	62493021	62493021	+	Silent	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:62493021C>T	uc002jei.2	-	c.66G>A	c.(64-66)GGG>GGA	p.G22G	POLG2_uc010deg.1_Silent_p.G22G	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	22					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			Colon(3;18 21 435 17652 48887)								0.339623	52.634089	53.839066	18	35	KEEP	---	---	---	---	capture		Silent	SNP	62493021	62493021	12629	17	C	T	T	T	275	22	POLG2	2	2
WRAP53	55135	broad.mit.edu	37	17	7606726	7606726	+	Silent	SNP	A	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:7606726A>T	uc010vuh.1	+	c.1569A>T	c.(1567-1569)CCA>CCT	p.P523P	WRAP53_uc010vui.1_Silent_p.P523P|WRAP53_uc002gip.2_Silent_p.P523P|WRAP53_uc002gir.2_Silent_p.P523P|WRAP53_uc002giq.2_Non-coding_Transcript|WRAP53_uc010cnl.2_Silent_p.P490P|EFNB3_uc002gis.2_5'Flank	NM_001143990	NP_001137462	Q9BUR4	WAP53_HUMAN	WD repeat domain 79 isoform 2	523					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0														0.2	7.016535	8.271999	3	12	KEEP	---	---	---	---	capture		Silent	SNP	7606726	7606726	17974	17	A	T	T	T	80	7	WRAP53	3	3
RPTOR	57521	broad.mit.edu	37	17	78704429	78704429	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:78704429G>A	uc002jyt.1	+	c.577G>A	c.(577-579)GTC>ATC	p.V193I	RPTOR_uc002jys.2_Missense_Mutation_p.V193I|RPTOR_uc010wuf.1_Missense_Mutation_p.V8I|RPTOR_uc010wug.1_Missense_Mutation_p.V193I	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	193					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding	p.V193I(1)		lung(4)|urinary_tract(1)	5										1368				0.25	44.176896	48.227213	18	54	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	78704429	78704429	14145	17	G	A	A	A	520	40	RPTOR	1	1
KRBA2	124751	broad.mit.edu	37	17	8273312	8273312	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:8273312C>A	uc002glf.1	-	c.619G>T	c.(619-621)GGT>TGT	p.G207C	KRBA2_uc002glg.1_Missense_Mutation_p.G124C	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	207					DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0														0.188679	23.619044	28.425148	10	43	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	8273312	8273312	8755	17	C	A	A	A	273	21	KRBA2	2	2
ASXL3	80816	broad.mit.edu	37	18	31325198	31325198	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:31325198G>A	uc010dmg.1	+	c.5386G>A	c.(5386-5388)GTT>ATT	p.V1796I	ASXL3_uc002kxq.2_Missense_Mutation_p.V1503I	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1796					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3														0.324324	102.672809	105.707341	36	75	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	31325198	31325198	1087	18	G	A	A	A	520	40	ASXL3	1	1
ZNF567	163081	broad.mit.edu	37	19	37209889	37209889	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:37209889A>G	uc010xtl.1	+	c.263A>G	c.(262-264)AAG>AGG	p.K88R	ZNF567_uc002oeo.1_Missense_Mutation_p.K88R|ZNF567_uc010xtk.1_Missense_Mutation_p.K88R|ZNF567_uc002oep.3_Missense_Mutation_p.K57R|ZNF567_uc002oeq.1_Missense_Mutation_p.K57R	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)											0.363636	25.794522	26.154262	8	14	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	37209889	37209889	18593	19	A	G	G	G	39	3	ZNF567	4	4
PPP1R13L	10848	broad.mit.edu	37	19	45899438	45899438	+	Silent	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:45899438C>T	uc002pbn.2	-	c.891G>A	c.(889-891)GGG>GGA	p.G297G	PPP1R13L_uc002pbo.2_Silent_p.G297G|PPP1R13L_uc002pbp.2_Silent_p.G297G	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	297	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding				0		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		Pancreas(61;1447 1663 31419 50578)								1	8.177128	7.953938	2	0	KEEP	---	---	---	---	capture		Silent	SNP	45899438	45899438	12793	19	C	T	T	T	275	22	PPP1R13L	2	2
TRIM45	80263	broad.mit.edu	37	1	117654991	117654991	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:117654991G>T	uc001egz.2	-	c.1679C>A	c.(1678-1680)TCT>TAT	p.S560Y	TRIM45_uc009whe.2_Missense_Mutation_p.S542Y|TRIM45_uc001eha.2_Missense_Mutation_p.S456Y	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	560						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)										0.212903	72.096441	83.898772	33	122	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	117654991	117654991	17065	1	G	T	T	T	429	33	TRIM45	2	2
GJA8	2703	broad.mit.edu	37	1	147380358	147380358	+	Nonsense_Mutation	SNP	C	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:147380358C>G	uc001epu.1	+	c.276C>G	c.(274-276)TAC>TAG	p.Y92*		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	92	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)	5	all_hematologic(923;0.0276)					Melanoma(76;1255 1795 8195 52096)								0.25	60.614414	65.609319	22	66	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	147380358	147380358	6673	1	C	G	G	G	246	19	GJA8	5	3
FCRL2	79368	broad.mit.edu	37	1	157736756	157736756	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:157736756C>T	uc001fre.2	-	c.1168G>A	c.(1168-1170)GAT>AAT	p.D390N	FCRL2_uc001frd.2_Missense_Mutation_p.D137N|FCRL2_uc010phz.1_Missense_Mutation_p.D390N|FCRL2_uc009wsp.2_Missense_Mutation_p.D106N	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	390	Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)											0.211765	81.498895	94.563106	36	134	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	157736756	157736756	6032	1	C	T	T	T	377	29	FCRL2	2	2
DCAF6	55827	broad.mit.edu	37	1	167973205	167973205	+	Silent	SNP	A	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:167973205A>T	uc001gex.2	+	c.1095A>T	c.(1093-1095)GGA>GGT	p.G365G	DCAF6_uc001gev.2_Silent_p.G365G|DCAF6_uc001gew.2_Silent_p.G365G|DCAF6_uc010plk.1_Silent_p.G334G|DCAF6_uc001gey.2_Silent_p.G218G	NM_018442	NP_060912	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform a	365					positive regulation of transcription from RNA polymerase II promoter|protein ubiquitination	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)	2														0.32	66.273226	68.432466	24	51	KEEP	---	---	---	---	capture		Silent	SNP	167973205	167973205	4445	1	A	T	T	T	119	10	DCAF6	3	3
LPGAT1	9926	broad.mit.edu	37	1	212002507	212002507	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:212002507C>A	uc001hiu.2	-	c.132G>T	c.(130-132)CAG>CAT	p.Q44H	LPGAT1_uc001hiv.2_Missense_Mutation_p.Q44H	NM_014873	NP_055688	Q92604	LGAT1_HUMAN	lysophosphatidylglycerol acyltransferase 1	44					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00773)|all cancers(67;0.0765)|Epithelial(68;0.114)										0.272727	37.297138	39.860426	15	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	212002507	212002507	9287	1	C	A	A	A	363	28	LPGAT1	2	2
OR2M3	127062	broad.mit.edu	37	1	248367126	248367126	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:248367126G>A	uc010pzg.1	+	c.757G>A	c.(757-759)GGA>AGA	p.G253R		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)											0.25098	167.773203	182.144581	64	191	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	248367126	248367126	11417	1	G	A	A	A	611	47	OR2M3	2	2
HDAC1	3065	broad.mit.edu	37	1	32793141	32793141	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:32793141C>T	uc001bvb.1	+	c.499C>T	c.(499-501)CAC>TAC	p.H167Y	HDAC1_uc010ohd.1_Missense_Mutation_p.H167Y|HDAC1_uc010ohe.1_Missense_Mutation_p.H104Y|HDAC1_uc010ohf.1_Missense_Mutation_p.H138Y|HDAC1_uc001bvc.1_5'Flank	NM_004964	NP_004955	Q13547	HDAC1_HUMAN	histone deacetylase 1	167	Histone deacetylase.				anti-apoptosis|blood coagulation|chromatin remodeling|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|negative regulation of gene-specific transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of receptor biosynthetic process	cytosol|NuRD complex|Sin3 complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)					156				0.142857	7.182532	10.622591	4	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	32793141	32793141	7287	1	C	T	T	T	377	29	HDAC1	2	2
DMAP1	55929	broad.mit.edu	37	1	44684806	44684806	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:44684806G>A	uc001clq.1	+	c.799G>A	c.(799-801)GAC>AAC	p.D267N	DMAP1_uc001clr.1_Missense_Mutation_p.D267N|DMAP1_uc001cls.1_Missense_Mutation_p.D267N|DMAP1_uc010oku.1_Missense_Mutation_p.D257N	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	267	Potential.				DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding|transcription repressor activity				0	Acute lymphoblastic leukemia(166;0.155)													0.526316	61.500636	61.523494	20	18	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	44684806	44684806	4756	1	G	A	A	A	533	41	DMAP1	2	2
KANK4	163782	broad.mit.edu	37	1	62739507	62739507	+	Silent	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:62739507C>T	uc001dah.3	-	c.1269G>A	c.(1267-1269)TTG>TTA	p.L423L	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	423										ovary(3)|lung(1)	4														0.358209	135.770016	138.139188	48	86	KEEP	---	---	---	---	capture		Silent	SNP	62739507	62739507	8283	1	C	T	T	T	376	29	KANK4	2	2
RALGAPA2	57186	broad.mit.edu	37	20	20569944	20569944	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:20569944C>G	uc002wrz.2	-	c.2407G>C	c.(2407-2409)GGA>CGA	p.G803R	RALGAPA2_uc010gcx.2_Missense_Mutation_p.G507R|RALGAPA2_uc010zsg.1_Missense_Mutation_p.G251R	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	803					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1														0.36	24.365983	24.798167	9	16	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20569944	20569944	13474	20	C	G	G	G	312	24	RALGAPA2	3	3
SLC12A5	57468	broad.mit.edu	37	20	44672539	44672539	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:44672539G>A	uc010zxl.1	+	c.1430G>A	c.(1429-1431)GGG>GAG	p.G477E	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.G454E	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	477	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)									0.220779	42.932287	48.459928	17	60	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	44672539	44672539	14881	20	G	A	A	A	559	43	SLC12A5	2	2
ZNF831	128611	broad.mit.edu	37	20	57769451	57769451	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:57769451C>A	uc002yan.2	+	c.3377C>A	c.(3376-3378)TCC>TAC	p.S1126Y		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1126						intracellular	nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(29;0.0085)													0.107143	2.228881	6.496183	3	25	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57769451	57769451	18784	20	C	A	A	A	390	30	ZNF831	2	2
LRP1B	53353	broad.mit.edu	37	2	141245284	141245284	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:141245284C>A	uc002tvj.1	-	c.9145G>T	c.(9145-9147)GAC>TAC	p.D3049Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3049	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.D3049Y(1)		lung(17)|ovary(10)|pancreas(3)|central_nervous_system(2)|liver(1)|kidney(1)	34		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		Colon(99;50 2074 2507 20106)				2546	TSP Lung(27;0.18)			0.208333	10.862607	12.752898	5	19	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	141245284	141245284	9328	2	C	A	A	A	416	32	LRP1B	2	2
PLCL1	5334	broad.mit.edu	37	2	198968574	198968574	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:198968574C>T	uc010fsp.2	+	c.3019C>T	c.(3019-3021)CAT>TAT	p.H1007Y	PLCL1_uc002uuv.3_Missense_Mutation_p.H928Y	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	1007					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)	1					Quinacrine(DB01103)									0.265625	86.138908	92.538771	34	94	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	198968574	198968574	12465	2	C	T	T	T	377	29	PLCL1	2	2
SMARCAL1	50485	broad.mit.edu	37	2	217285167	217285167	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:217285167G>T	uc002vgc.3	+	c.1008G>T	c.(1006-1008)ATG>ATT	p.M336I	SMARCAL1_uc010fvf.2_Non-coding_Transcript|SMARCAL1_uc002vgd.3_Missense_Mutation_p.M336I|SMARCAL1_uc010fvg.2_Missense_Mutation_p.M336I	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	336					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)										0.180328	23.086232	28.949019	11	50	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	217285167	217285167	15271	2	G	T	T	T	598	46	SMARCAL1	2	2
GMPPA	29926	broad.mit.edu	37	2	220371144	220371144	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:220371144G>T	uc002vlt.2	+	c.1321G>T	c.(1321-1323)GGC>TGC	p.G441C	GMPPA_uc002vlr.2_Missense_Mutation_p.G388C|GMPPA_uc002vls.2_Missense_Mutation_p.G388C|GMPPA_uc002vlu.2_Missense_Mutation_p.G441C|GMPPA_uc002vlv.2_Missense_Mutation_p.G388C|GMPPA_uc002vlw.2_Non-coding_Transcript|GMPPA_uc002vlx.2_Missense_Mutation_p.G388C	NM_205847	NP_995319	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	388					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)										0.380952	22.994727	23.255823	8	13	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	220371144	220371144	6763	2	G	T	T	T	559	43	GMPPA	2	2
RAB17	64284	broad.mit.edu	37	2	238486012	238486012	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:238486012T>C	uc002vwz.1	-	c.323A>G	c.(322-324)AAG>AGG	p.K108R	RAB17_uc002vxa.1_Non-coding_Transcript|RAB17_uc002vxb.1_Non-coding_Transcript	NM_022449	NP_071894	Q9H0T7	RAB17_HUMAN	RAB17, member RAS oncogene family	108					protein transport|small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|protein binding				0		Renal(207;0.00272)|Breast(86;0.00297)|all_hematologic(139;0.182)|Ovarian(221;0.221)		Epithelial(121;9.36e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.26e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000354)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.026)		Colon(56;987 1029 6466 13943 27336)								0.291667	41.630378	43.496438	14	34	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	238486012	238486012	13361	2	T	C	C	C	728	56	RAB17	4	4
ALK	238	broad.mit.edu	37	2	29541192	29541192	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:29541192G>C	uc002rmy.2	-	c.1625C>G	c.(1624-1626)CCG>CGG	p.P542R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	542	MAM 2.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.P542R(1)	NPM1/ALK(632)|EML4/ALK(191)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(14)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(200)|autonomic_ganglia(95)|soft_tissue(59)|kidney(4)|large_intestine(3)|ovary(3)|central_nervous_system(1)|breast(1)|pancreas(1)	1093	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)					777				0.15942	23.287162	30.905325	11	58	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	29541192	29541192	528	2	G	C	C	C	507	39	ALK	3	3
SOS1	6654	broad.mit.edu	37	2	39214707	39214707	+	Silent	SNP	A	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:39214707A>G	uc002rrk.3	-	c.3417T>C	c.(3415-3417)AGT>AGC	p.S1139S	SOS1_uc002rrj.3_Silent_p.S738S	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	1139					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|lung(1)|central_nervous_system(1)	6		all_hematologic(82;0.21)								444				0.324324	38.988371	40.001174	12	25	KEEP	---	---	---	---	capture		Silent	SNP	39214707	39214707	15436	2	A	G	G	G	24	2	SOS1	4	4
PLEKHH2	130271	broad.mit.edu	37	2	43984326	43984326	+	Silent	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:43984326G>A	uc010yny.1	+	c.3864G>A	c.(3862-3864)GTG>GTA	p.V1288V		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1288	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)												0.285714	32.781635	34.512855	12	30	KEEP	---	---	---	---	capture		Silent	SNP	43984326	43984326	12503	2	G	A	A	A	574	45	PLEKHH2	2	2
LRRTM1	347730	broad.mit.edu	37	2	80529445	80529445	+	Silent	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:80529445G>T	uc002sok.1	-	c.1500C>A	c.(1498-1500)GCC>GCA	p.A500A	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_Non-coding_Transcript	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	500	Cytoplasmic (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)	3														0.275	26.797567	28.629422	11	29	KEEP	---	---	---	---	capture		Silent	SNP	80529445	80529445	9415	2	G	T	T	T	548	43	LRRTM1	2	2
SLC12A8	84561	broad.mit.edu	37	3	124909323	124909323	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:124909323A>G	uc003ehw.3	-	c.181T>C	c.(181-183)TTC>CTC	p.F61L	SLC12A8_uc003ehv.3_Missense_Mutation_p.F32L|SLC12A8_uc010hrz.1_5'UTR	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	32					potassium ion transport	integral to membrane	symporter activity				0														0.266129	95.7227	101.847247	33	91	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	124909323	124909323	14884	3	A	G	G	G	26	2	SLC12A8	4	4
RHO	6010	broad.mit.edu	37	3	129251219	129251219	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:129251219T>C	uc003emt.2	+	c.656T>C	c.(655-657)ATC>ACC	p.I219T		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	219	Helical; Name=5; (Potential).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	Esophageal Squamous(118;214 1623 30842 43234 46940)								0.352941	37.393476	38.04024	12	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	129251219	129251219	13805	3	T	C	C	C	650	50	RHO	4	4
DZIP1L	199221	broad.mit.edu	37	3	137787060	137787060	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:137787060C>A	uc003erq.2	-	c.1765G>T	c.(1765-1767)GCC>TCC	p.A589S		NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	589						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2														0.275862	34.021256	36.689981	16	42	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	137787060	137787060	5050	3	C	A	A	A	351	27	DZIP1L	1	1
CPB1	1360	broad.mit.edu	37	3	148577707	148577707	+	Missense_Mutation	SNP	A	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:148577707A>T	uc003ewl.2	+	c.1172A>T	c.(1171-1173)GAA>GTA	p.E391V		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	391					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)											0.277108	52.888234	56.601201	23	60	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	148577707	148577707	3934	3	A	T	T	T	117	9	CPB1	3	3
ABCC5	10057	broad.mit.edu	37	3	183682984	183682984	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:183682984C>A	uc003fmg.2	-	c.2020G>T	c.(2020-2022)GAC>TAC	p.D674Y	ABCC5_uc011bqt.1_Missense_Mutation_p.D202Y|ABCC5_uc010hxl.2_Missense_Mutation_p.D674Y	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	674	ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)											0.25	41.1718	44.806364	16	48	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	183682984	183682984	57	3	C	A	A	A	403	31	ABCC5	1	1
ABCF3	55324	broad.mit.edu	37	3	183909039	183909039	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:183909039G>A	uc003fmz.2	+	c.1565G>A	c.(1564-1566)TGT>TAT	p.C522Y	ABCF3_uc003fna.2_Missense_Mutation_p.C516Y|ABCF3_uc003fnb.2_Missense_Mutation_p.C203Y	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	522	ABC transporter 2.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)											0.274336	77.593102	82.766527	31	82	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	183909039	183909039	68	3	G	A	A	A	624	48	ABCF3	2	2
RTP1	132112	broad.mit.edu	37	3	186917762	186917762	+	Silent	SNP	A	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:186917762A>T	uc003frg.2	+	c.696A>T	c.(694-696)TCA>TCT	p.S232S		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	232	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)										0.257576	90.906357	97.925724	34	98	KEEP	---	---	---	---	capture		Silent	SNP	186917762	186917762	14213	3	A	T	T	T	80	7	RTP1	3	3
EPHA6	285220	broad.mit.edu	37	3	96585677	96585677	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:96585677C>A	uc010how.1	+	c.394C>A	c.(394-396)CTT>ATT	p.L132I	EPHA6_uc003drp.1_Missense_Mutation_p.L132I	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	37	Ephrin-binding.|Extracellular (Potential).				protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(3)|lung(3)|stomach(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	12										480				0.5	16.074868	16.074868	5	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	96585677	96585677	5364	3	C	A	A	A	364	28	EPHA6	2	2
ANK2	287	broad.mit.edu	37	4	114288770	114288770	+	Missense_Mutation	SNP	A	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:114288770A>C	uc003ibe.3	+	c.11081A>C	c.(11080-11082)AAA>ACA	p.K3694T	ANK2_uc003ibd.3_Missense_Mutation_p.K1600T|ANK2_uc003ibf.3_Missense_Mutation_p.K1609T|ANK2_uc011cgc.1_Missense_Mutation_p.K785T|ANK2_uc003ibg.3_Missense_Mutation_p.K593T|ANK2_uc003ibh.3_Missense_Mutation_p.K283T|ANK2_uc011cgd.1_Missense_Mutation_p.K996T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3661					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)	13		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)										0.448276	87.944878	88.079836	26	32	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	114288770	114288770	624	4	A	C	C	C	13	1	ANK2	4	4
STIM2	57620	broad.mit.edu	37	4	27009159	27009159	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:27009159G>A	uc003gsh.3	+	c.1247G>A	c.(1246-1248)CGC>CAC	p.R416H	STIM2_uc003gsg.3_Missense_Mutation_p.R416H|STIM2_uc010iex.2_Missense_Mutation_p.R416H|STIM2_uc010iey.2_Missense_Mutation_p.R40H	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	329	Cytoplasmic (Potential).|Potential.				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)	1		Breast(46;0.0503)												0.173913	16.580286	21.19014	8	38	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	27009159	27009159	15804	4	G	A	A	A	494	38	STIM2	1	1
C4orf50	389197	broad.mit.edu	37	4	5961120	5961120	+	Silent	SNP	C	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:5961120C>G	uc003git.1	-	c.813G>C	c.(811-813)CCG>CCC	p.P271P		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	271										pancreas(2)|breast(1)	3														0.298507	60.982317	63.408641	20	47	KEEP	---	---	---	---	capture		Silent	SNP	5961120	5961120	2373	4	C	G	G	G	340	27	C4orf50	3	3
UGT2A1	10941	broad.mit.edu	37	4	70505119	70505119	+	Silent	SNP	A	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:70505119A>G	uc011caq.1	-	c.843T>C	c.(841-843)TTT>TTC	p.F281F	UGT2A1_uc010ihu.2_Intron|UGT2A1_uc003hem.3_Intron|UGT2A1_uc010iht.2_Intron|UGT2A1_uc010ihs.2_Silent_p.F72F	NM_001105677	NP_001099147	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	71	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1														0.355828	166.138851	169.108536	58	105	KEEP	---	---	---	---	capture		Silent	SNP	70505119	70505119	17511	4	A	G	G	G	63	5	UGT2A1	4	4
APC	324	broad.mit.edu	37	5	112103015	112103015	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:112103015C>T	uc010jby.2	+	c.350C>T	c.(349-351)TCA>TTA	p.S117L	APC_uc011cvt.1_Missense_Mutation_p.S127L|APC_uc003kpz.3_Missense_Mutation_p.S117L|APC_uc003kpy.3_Missense_Mutation_p.S117L|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	117	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of protein catabolic process|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.S117L(1)		large_intestine(2012)|stomach(123)|soft_tissue(55)|small_intestine(34)|pancreas(25)|breast(23)|urinary_tract(20)|lung(18)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|upper_aerodigestive_tract(6)|adrenal_gland(6)|NS(5)|bone(5)|skin(4)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2396		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		NSCLC(107;854 1218 9699 17025 28335 47076 52975)|Esophageal Squamous(32;282 584 32991 36563 39392 49665 50115)		12		629	TSP Lung(16;0.13)			0.363636	70.481558	71.561554	24	42	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	112103015	112103015	773	5	C	T	T	T	377	29	APC	2	2
MYOT	9499	broad.mit.edu	37	5	137213289	137213289	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:137213289C>G	uc011cye.1	+	c.612C>G	c.(610-612)GAC>GAG	p.D204E	MYOT_uc003lbv.2_Missense_Mutation_p.D204E|MYOT_uc011cyg.1_Missense_Mutation_p.D20E|MYOT_uc011cyh.1_Missense_Mutation_p.D89E	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	204					muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)											0.425532	66.190521	66.418289	20	27	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	137213289	137213289	10489	5	C	G	G	G	220	17	MYOT	3	3
DOCK2	1794	broad.mit.edu	37	5	169484670	169484670	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:169484670G>T	uc003maf.2	+	c.4467G>T	c.(4465-4467)CAG>CAT	p.Q1489H	DOCK2_uc011der.1_Non-coding_Transcript|DOCK2_uc010jjm.2_Missense_Mutation_p.Q981H|DOCK2_uc003mah.2_Missense_Mutation_p.Q45H	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1489	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)											0.25	39.239741	42.620077	15	45	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	169484670	169484670	4871	5	G	T	T	T	451	35	DOCK2	2	2
LMBRD2	92255	broad.mit.edu	37	5	36136536	36136536	+	Nonsense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:36136536C>A	uc003jkb.1	-	c.622G>T	c.(622-624)GAA>TAA	p.E208*		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	208	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)							2				0.442308	60.012781	60.163711	23	29	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	36136536	36136536	9172	5	C	A	A	A	390	30	LMBRD2	5	2
BPGM	669	broad.mit.edu	37	7	134346797	134346797	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:134346797G>T	uc003vrv.2	+	c.538G>T	c.(538-540)GGC>TGC	p.G180C	BPGM_uc003vrw.2_Missense_Mutation_p.G180C|BPGM_uc003vrx.2_Missense_Mutation_p.G180C	NM_199186	NP_954655	P07738	PMGE_HUMAN	bisphosphoglycerate mutase	180					glycolysis|respiratory gaseous exchange		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0														0.301724	99.684188	103.754129	35	81	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	134346797	134346797	1516	7	G	T	T	T	611	47	BPGM	2	2
AKR1D1	6718	broad.mit.edu	37	7	137776536	137776536	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:137776536C>A	uc003vtz.2	+	c.284C>A	c.(283-285)CCA>CAA	p.P95Q	AKR1D1_uc011kqb.1_Missense_Mutation_p.P95Q|AKR1D1_uc011kqc.1_Non-coding_Transcript|AKR1D1_uc011kqd.1_Intron|AKR1D1_uc011kqe.1_Missense_Mutation_p.P95Q|AKR1D1_uc011kqf.1_Missense_Mutation_p.P95Q|AKR1D1_uc010lmy.1_Non-coding_Transcript	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	95					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion|oxidation-reduction process	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding				0														0.338983	59.180433	60.533617	20	39	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	137776536	137776536	476	7	C	A	A	A	273	21	AKR1D1	2	2
OR2A5	393046	broad.mit.edu	37	7	143748072	143748072	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:143748072G>C	uc011ktw.1	+	c.578G>C	c.(577-579)TGG>TCG	p.W193S		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)													0.265753	247.384851	265.502736	97	268	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	143748072	143748072	11387	7	G	C	C	C	611	47	OR2A5	3	3
SSPO	23145	broad.mit.edu	37	7	149489172	149489172	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:149489172G>T	uc010lpk.2	+	c.5417G>T	c.(5416-5418)GGC>GTC	p.G1806V		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1806	TSP type-1 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)											0.333333	11.496098	11.791256	4	8	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	149489172	149489172	15705	7	G	T	T	T	546	42	SSPO	2	2
BBS9	27241	broad.mit.edu	37	7	33545232	33545232	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:33545232C>T	uc003tdn.1	+	c.2273C>T	c.(2272-2274)CCG>CTG	p.P758L	BBS9_uc003tdo.1_Missense_Mutation_p.P723L|BBS9_uc003tdp.1_Missense_Mutation_p.P753L|BBS9_uc003tdq.1_Missense_Mutation_p.P718L|BBS9_uc010kwn.1_Non-coding_Transcript|BBS9_uc003tdr.1_Missense_Mutation_p.P282L|BBS9_uc003tds.1_Missense_Mutation_p.P181L|BBS9_uc003tdt.2_Non-coding_Transcript	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	758					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(11;0.0894)											0.244898	59.989578	65.774326	24	74	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	33545232	33545232	1363	7	C	T	T	T	299	23	BBS9	1	1
PLEC	5339	broad.mit.edu	37	8	145008878	145008878	+	Silent	SNP	C	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:145008878C>T	uc003zaf.1	-	c.1377G>A	c.(1375-1377)CTG>CTA	p.L459L	PLEC_uc003zab.1_Silent_p.L322L|PLEC_uc003zac.1_Silent_p.L326L|PLEC_uc003zad.2_Silent_p.L322L|PLEC_uc003zae.1_Silent_p.L290L|PLEC_uc003zag.1_Silent_p.L300L|PLEC_uc003zah.2_Silent_p.L308L|PLEC_uc003zaj.2_Silent_p.L349L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	459	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|central_nervous_system(1)	7														0.428571	9.023719	9.054911	3	4	KEEP	---	---	---	---	capture		Silent	SNP	145008878	145008878	12478	8	C	T	T	T	366	29	PLEC	2	2
WHSC1L1	54904	broad.mit.edu	37	8	38133995	38133995	+	Missense_Mutation	SNP	T	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:38133995T>G	uc003xli.2	-	c.3891A>C	c.(3889-3891)GAA>GAC	p.E1297D	WHSC1L1_uc011lbm.1_Missense_Mutation_p.E1286D|WHSC1L1_uc010lwe.2_Missense_Mutation_p.E1248D|WHSC1L1_uc003xlh.2_Missense_Mutation_p.E76D	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	1297					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|zinc ion binding				0	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)							521				0.4	25.695826	25.870816	8	12	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	38133995	38133995	17937	8	T	G	G	G	725	56	WHSC1L1	4	4
PENK	5179	broad.mit.edu	37	8	57358431	57358431	+	Nonsense_Mutation	SNP	G	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:57358431G>A	uc003xsz.2	-	c.82C>T	c.(82-84)CAG>TAG	p.Q28*	PENK_uc003xta.3_Nonsense_Mutation_p.Q28*|PENK_uc010lym.2_Nonsense_Mutation_p.Q28*	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	28					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)	3		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)											0.238095	13.064182	14.380075	5	16	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	57358431	57358431	12148	8	G	A	A	A	611	47	PENK	5	2
ERMP1	79956	broad.mit.edu	37	9	5805697	5805697	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:5805697C>A	uc003zjm.1	-	c.1637G>T	c.(1636-1638)GGA>GTA	p.G546V	ERMP1_uc011lme.1_Non-coding_Transcript|ERMP1_uc010mhs.1_Missense_Mutation_p.G160V	NM_024896	NP_079172	Q7Z2K6	ERMP1_HUMAN	aminopeptidase Fxna	546	Helical; (Potential).				proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)										0.267857	75.798644	81.249141	30	82	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	5805697	5805697	5429	9	C	A	A	A	390	30	ERMP1	2	2
SLITRK2	84631	broad.mit.edu	37	X	144905148	144905148	+	Missense_Mutation	SNP	A	T	T			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:144905148A>T	uc004fcd.2	+	c.1205A>T	c.(1204-1206)GAC>GTC	p.D402V	SLITRK2_uc010nsp.2_Missense_Mutation_p.D402V|SLITRK2_uc010nso.2_Missense_Mutation_p.D402V|SLITRK2_uc011mwq.1_Missense_Mutation_p.D402V|SLITRK2_uc011mwr.1_Missense_Mutation_p.D402V|SLITRK2_uc011mws.1_Missense_Mutation_p.D402V|SLITRK2_uc004fcg.2_Missense_Mutation_p.D402V|SLITRK2_uc011mwt.1_Missense_Mutation_p.D402V	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	402	Extracellular (Potential).|LRR 8.					integral to membrane				ovary(4)|pancreas(1)	5	Acute lymphoblastic leukemia(192;6.56e-05)													0.525	66.376469	66.398199	21	19	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	144905148	144905148	15241	23	A	T	T	T	130	10	SLITRK2	3	3
KEAP1	9817	broad.mit.edu	37	19	10600356	10600356	+	Frame_Shift_Del	DEL	A	-	-			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:10600356_10600356delA	uc002moq.1	-	c.1499_1499delT	c.(1498-1500)ATCfs	p.I500fs	KEAP1_uc002mop.1_Frame_Shift_Del_p.I218fs|KEAP1_uc002mor.1_Frame_Shift_Del_p.I500fs	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	500	Kelch 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(2)|ovary(1)|pancreas(1)	4			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)											0.38			6	10		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	10600356	10600356	8447	19	A	-	-	-	156	12	KEAP1	5	5
MEGF8	1954	broad.mit.edu	37	19	42857115	42857116	+	Frame_Shift_Ins	INS	-	C	C			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:42857115_42857116insC	uc002otl.3	+	c.3185_3186insC	c.(3184-3186)GGCfs	p.G1062fs	MEGF8_uc002otm.3_Frame_Shift_Ins_p.G670fs	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1129	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)												0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	42857115	42857116	9852	19	-	C	C	C	546	42	MEGF8	5	5
HSPBP1	23640	broad.mit.edu	37	19	55789106	55789107	+	Frame_Shift_Ins	INS	-	G	G			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:55789106_55789107insG	uc002qjx.2	-	c.456_457insC	c.(454-459)CCCACTfs	p.P152fs	HSPBP1_uc002qjy.2_Frame_Shift_Ins_p.P106fs|HSPBP1_uc002qkb.2_Frame_Shift_Ins_p.P106fs|HSPBP1_uc002qka.2_Frame_Shift_Ins_p.P106fs|HSPBP1_uc002qkd.2_Frame_Shift_Ins_p.P106fs|HSPBP1_uc002qkc.2_Frame_Shift_Ins_p.P106fs	NM_012267	NP_036399	Q9NZL4	HPBP1_HUMAN	hsp70-interacting protein	109_110					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)										0.50			3	3		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	55789106	55789107	7726	19	-	G	G	G	767	59	HSPBP1	5	5
KIAA0895	23366	broad.mit.edu	37	7	36429736	36429736	+	Splice_Site_Del	DEL	C	-	-			TCGA-17-Z036-01	TCGA-17-Z036-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:36429736_36429736delC	uc003tfd.2	-	c.-50_splice	c.e1-1		ANLN_uc003tff.2_Intron|ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Intron|ANLN_uc010kxe.2_Intron	NM_001100425	NP_001093895			hypothetical protein LOC23366 isoform 1												0														0.55			6	5		---	---	---	---	capture_indel		Splice_Site_Del	DEL	36429736	36429736	8504	7	C	-	-	-	222	18	KIAA0895	5	5
