Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
SORCS1	114815	broad.mit.edu	37	10	108439436	108439436	+	Silent	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:108439436C>A	uc001kyl.2	-	c.1617G>T	c.(1615-1617)GGG>GGT	p.G539G	SORCS1_uc001kym.2_Silent_p.G539G|SORCS1_uc009xxs.2_Silent_p.G539G|SORCS1_uc001kyn.1_Silent_p.G539G|SORCS1_uc001kyo.2_Silent_p.G539G	NM_001013031	NP_001013049	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform b	539	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)	1		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)										0.32	21.890541	22.610551	8	17	KEEP	---	---	---	---	capture		Silent	SNP	108439436	108439436	15430	10	C	A	A	A	379	30	SORCS1	2	2
CHAT	1103	broad.mit.edu	37	10	50827817	50827817	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:50827817C>G	uc001jhz.2	+	c.434C>G	c.(433-435)ACG>AGG	p.T145R	CHAT_uc001jhv.1_Missense_Mutation_p.T27R|CHAT_uc001jhx.1_Missense_Mutation_p.T27R|CHAT_uc001jhy.1_Missense_Mutation_p.T27R|CHAT_uc001jia.2_Missense_Mutation_p.T27R|CHAT_uc010qgs.1_Missense_Mutation_p.T27R	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	145					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)									0.3125	14.470048	14.970318	5	11	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	50827817	50827817	3447	10	C	G	G	G	247	19	CHAT	3	3
LIPK	643414	broad.mit.edu	37	10	90512289	90512289	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:90512289T>C	uc010qmv.1	+	c.976T>C	c.(976-978)TAC>CAC	p.Y326H		NM_001080518	NP_001073987	Q5VXJ0	LIPK_HUMAN	lipase, family member K precursor	326					lipid catabolic process	extracellular region	hydrolase activity			ovary(2)	2		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)										0.714286	17.978288	18.267056	5	2	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	90512289	90512289	9154	10	T	C	C	C	637	49	LIPK	4	4
ZNF202	7753	broad.mit.edu	37	11	123598271	123598271	+	Nonsense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:123598271G>A	uc001pzd.1	-	c.865C>T	c.(865-867)CAG>TAG	p.Q289*	ZNF202_uc001pzc.1_Nonsense_Mutation_p.Q65*|ZNF202_uc001pze.1_Nonsense_Mutation_p.Q289*|ZNF202_uc001pzf.1_Nonsense_Mutation_p.Q289*	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	289	KRAB.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|specific RNA polymerase II transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)										0.710526	187.181544	190.202294	54	22	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	123598271	123598271	18354	11	G	A	A	A	611	47	ZNF202	5	2
OR10G4	390264	broad.mit.edu	37	11	123886970	123886970	+	Nonsense_Mutation	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:123886970C>G	uc010sac.1	+	c.689C>G	c.(688-690)TCA>TGA	p.S230*		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)										0.525641	138.473792	138.51806	41	37	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	123886970	123886970	11307	11	C	G	G	G	377	29	OR10G4	5	3
ROBO4	54538	broad.mit.edu	37	11	124757359	124757359	+	Missense_Mutation	SNP	A	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:124757359A>T	uc001qbg.2	-	c.2093T>A	c.(2092-2094)CTG>CAG	p.L698Q	ROBO4_uc010sas.1_Missense_Mutation_p.L553Q|ROBO4_uc001qbh.2_Missense_Mutation_p.L588Q|ROBO4_uc001qbi.2_Missense_Mutation_p.L256Q	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	698					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)										0.261905	28.22247	30.366323	11	31	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	124757359	124757359	13995	11	A	T	T	T	91	7	ROBO4	3	3
STT3A	3703	broad.mit.edu	37	11	125482928	125482928	+	Silent	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:125482928C>G	uc001qcd.2	+	c.1410C>G	c.(1408-1410)ACC>ACG	p.T470T	STT3A_uc001qce.2_Silent_p.T470T|STT3A_uc010sbg.1_Silent_p.T378T|STT3A_uc009zbn.2_Silent_p.T192T	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	470	Helical; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)										0.521739	215.399657	215.456922	72	66	KEEP	---	---	---	---	capture		Silent	SNP	125482928	125482928	15853	11	C	G	G	G	301	24	STT3A	3	3
FLI1	2313	broad.mit.edu	37	11	128642802	128642802	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:128642802A>G	uc010sbu.1	+	c.511A>G	c.(511-513)AAC>GAC	p.N171D	FLI1_uc010sbt.1_Intron|FLI1_uc010sbv.1_Missense_Mutation_p.N138D|FLI1_uc009zci.2_Missense_Mutation_p.N105D	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	171	PNT.				hemostasis|organ morphogenesis|regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2262)	bone(2208)|soft_tissue(46)|autonomic_ganglia(4)|central_nervous_system(4)|ovary(2)|pancreas(2)|lung(1)	2267	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)						400				0.325714	161.393978	166.121588	57	118	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	128642802	128642802	6162	11	A	G	G	G	117	9	FLI1	4	4
B3GAT1	27087	broad.mit.edu	37	11	134257560	134257560	+	Silent	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:134257560G>T	uc010scv.1	-	c.33C>A	c.(31-33)GCC>GCA	p.A11A	B3GAT1_uc001qhq.2_5'UTR|B3GAT1_uc001qhr.2_5'UTR	NM_054025	NP_473366	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	Error:Variant_position_missing_in_Q9P2W7_after_alignment					carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)										0.75	10.227692	10.453997	3	1	KEEP	---	---	---	---	capture		Silent	SNP	134257560	134257560	1274	11	G	T	T	T	443	35	B3GAT1	2	2
PDHX	8050	broad.mit.edu	37	11	34978962	34978962	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:34978962G>T	uc001mvt.2	+	c.374G>T	c.(373-375)GGT>GTT	p.G125V	PDHX_uc010rep.1_Missense_Mutation_p.G110V|PDHX_uc010req.1_Intron	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	125	Lipoyl-binding.				pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)											0.676471	66.323449	67.25999	23	11	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	34978962	34978962	12088	11	G	T	T	T	572	44	PDHX	2	2
OR5D18	219438	broad.mit.edu	37	11	55587141	55587141	+	Silent	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:55587141G>T	uc010rin.1	+	c.36G>T	c.(34-36)ACG>ACT	p.T12T		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)												0.614583	201.145312	202.253587	59	37	KEEP	---	---	---	---	capture		Silent	SNP	55587141	55587141	11567	11	G	T	T	T	509	40	OR5D18	1	1
OR5D18	219438	broad.mit.edu	37	11	55587801	55587801	+	Silent	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:55587801C>T	uc010rin.1	+	c.696C>T	c.(694-696)GTC>GTT	p.V232V		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)												0.654545	225.316471	227.632996	72	38	KEEP	---	---	---	---	capture		Silent	SNP	55587801	55587801	11567	11	C	T	T	T	366	29	OR5D18	2	2
OR5T2	219464	broad.mit.edu	37	11	55999704	55999704	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:55999704C>G	uc010rjc.1	-	c.958G>C	c.(958-960)GTG>CTG	p.V320L		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	320	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)													0.187135	79.895909	95.572801	32	139	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	55999704	55999704	11592	11	C	G	G	G	221	17	OR5T2	3	3
OR52E8	390079	broad.mit.edu	37	11	5878565	5878565	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:5878565G>T	uc010qzr.1	-	c.368C>A	c.(367-369)GCC>GAC	p.A123D	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	123	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)										0.092593	7.38365	52.530161	25	245	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	5878565	5878565	11528	11	G	T	T	T	546	42	OR52E8	2	2
SLC22A6	9356	broad.mit.edu	37	11	62751994	62751994	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:62751994G>C	uc001nwk.2	-	c.169C>G	c.(169-171)CTC>GTC	p.L57V	SLC22A6_uc001nwl.2_Missense_Mutation_p.L57V|SLC22A6_uc001nwj.2_Missense_Mutation_p.L57V|SLC22A6_uc001nwm.2_Missense_Mutation_p.L57V	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	57	Extracellular (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0														0.307692	19.588443	20.446742	8	18	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	62751994	62751994	14955	11	G	C	C	C	455	35	SLC22A6	3	3
MRGPRF	116535	broad.mit.edu	37	11	68773708	68773708	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:68773708C>T	uc001ooo.3	-	c.70G>A	c.(70-72)GCC>ACC	p.A24T	MRGPRF_uc001oop.3_Missense_Mutation_p.A24T	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	24	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)											0.736842	43.088645	44.107011	14	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	68773708	68773708	10157	11	C	T	T	T	338	26	MRGPRF	2	2
NUP37	79023	broad.mit.edu	37	12	102512215	102512215	+	Nonsense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:102512215C>A	uc001tjc.2	-	c.82G>T	c.(82-84)GAG>TAG	p.E28*	NUP37_uc009zub.1_Nonsense_Mutation_p.E28*|C12orf48_uc001tjd.2_5'Flank|C12orf48_uc001tje.2_5'Flank|C12orf48_uc001tjg.2_5'Flank|C12orf48_uc010swa.1_5'Flank|C12orf48_uc001tjf.2_5'Flank|C12orf48_uc001tjh.2_5'Flank|C12orf48_uc010swb.1_5'Flank|C12orf48_uc001tji.2_5'Flank	NM_024057	NP_076962	Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	28					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1														0.584416	141.285302	141.764458	45	32	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	102512215	102512215	11169	12	C	A	A	A	377	29	NUP37	5	2
FBXL14	144699	broad.mit.edu	37	12	1702092	1702092	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:1702092G>A	uc001qjh.2	-	c.1141C>T	c.(1141-1143)CCG>TCG	p.P381S	WNT5B_uc009zdq.2_Intron|FBXL14_uc001qji.2_Missense_Mutation_p.P293S	NM_152441	NP_689654	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	381						cytoplasm				ovary(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)											0.291667	17.914108	18.848033	7	17	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	1702092	1702092	5947	12	G	A	A	A	546	42	FBXL14	2	2
PKP2	5318	broad.mit.edu	37	12	32974305	32974305	+	Silent	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:32974305C>A	uc001rlj.3	-	c.2130G>T	c.(2128-2130)ACG>ACT	p.T710T	PKP2_uc001rlk.3_Silent_p.T666T|PKP2_uc010skj.1_Silent_p.T663T	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	710	ARM 5.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)													0.7	48.557804	49.272547	14	6	KEEP	---	---	---	---	capture		Silent	SNP	32974305	32974305	12410	12	C	A	A	A	288	23	PKP2	1	1
KRT73	319101	broad.mit.edu	37	12	53004610	53004610	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:53004610G>T	uc001sas.2	-	c.1120C>A	c.(1120-1122)CTG>ATG	p.L374M		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	374	Rod.|Coil 2.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)	4				BRCA - Breast invasive adenocarcinoma(357;0.189)										0.27027	26.132559	27.894898	10	27	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	53004610	53004610	8801	12	G	T	T	T	451	35	KRT73	2	2
GEFT	115557	broad.mit.edu	37	12	58010269	58010269	+	Silent	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:58010269G>A	uc009zpy.2	+	c.1740G>A	c.(1738-1740)CTG>CTA	p.L580L	GEFT_uc001spb.2_Silent_p.L541L|GEFT_uc001spa.2_Silent_p.L435L|GEFT_uc001spd.2_Silent_p.L246L	NM_001111270	NP_001104740	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 3	541					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)													0.5	56.547637	56.547637	18	18	KEEP	---	---	---	---	capture		Silent	SNP	58010269	58010269	6596	12	G	A	A	A	600	47	GEFT	2	2
CD163	9332	broad.mit.edu	37	12	7653807	7653807	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:7653807C>A	uc001qsz.3	-	c.385G>T	c.(385-387)GAT>TAT	p.D129Y	CD163_uc001qta.3_Missense_Mutation_p.D129Y|CD163_uc009zfw.2_Missense_Mutation_p.D129Y	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	129	SRCR 1.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8														0.103858	21.47937	74.127947	35	302	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	7653807	7653807	3094	12	C	A	A	A	390	30	CD163	2	2
HSP90AA1	3320	broad.mit.edu	37	14	102552661	102552661	+	Missense_Mutation	SNP	T	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:102552661T>A	uc001ykv.3	-	c.421A>T	c.(421-423)ACG>TCG	p.T141S	HSP90AA1_uc001yku.3_Missense_Mutation_p.T19S|HSP90AA1_uc001ykw.1_5'UTR|HSP90AA1_uc001ykx.1_Missense_Mutation_p.T8S	NM_001017963	NP_001017963	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 1	19					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)	4					Rifabutin(DB00615)					7				0.432432	45.794565	45.941658	16	21	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	102552661	102552661	7700	14	T	A	A	A	754	58	HSP90AA1	3	3
POTEG	404785	broad.mit.edu	37	14	19553789	19553789	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:19553789G>T	uc001vuz.1	+	c.373G>T	c.(373-375)GAC>TAC	p.D125Y	POTEG_uc001vva.1_Non-coding_Transcript|POTEG_uc010ahc.1_Non-coding_Transcript	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	125										ovary(1)	1														0.092664	9.319792	52.720832	24	235	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	19553789	19553789	12696	14	G	T	T	T	481	37	POTEG	1	1
POTEG	404785	broad.mit.edu	37	14	19573133	19573133	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:19573133G>A	uc001vuz.1	+	c.1231G>A	c.(1231-1233)GGT>AGT	p.G411S	POTEG_uc001vva.1_Non-coding_Transcript|POTEG_uc010ahc.1_Non-coding_Transcript	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	411										ovary(1)	1														0.195652	43.993584	51.939487	18	74	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	19573133	19573133	12696	14	G	A	A	A	611	47	POTEG	2	2
OR11H4	390442	broad.mit.edu	37	14	20711024	20711024	+	Missense_Mutation	SNP	T	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:20711024T>A	uc010tld.1	+	c.74T>A	c.(73-75)CTG>CAG	p.L25Q		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)										0.333333	43.038126	44.070289	14	28	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20711024	20711024	11334	14	T	A	A	A	715	55	OR11H4	3	3
SLC22A17	51310	broad.mit.edu	37	14	23817863	23817863	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:23817863G>A	uc001wjl.2	-	c.544C>T	c.(544-546)CCA>TCA	p.P182S	SLC22A17_uc010akk.2_Intron|SLC22A17_uc001wjn.2_Intron|SLC22A17_uc001wjm.2_Missense_Mutation_p.P182S|SLC22A17_uc010akl.1_3'UTR	NM_020372	NP_065105	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17 isoform a	182					siderophore transport|transmembrane transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transporter activity				0	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)										0.34375	33.9233	34.609593	11	21	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	23817863	23817863	14944	14	G	A	A	A	559	43	SLC22A17	2	2
NFATC4	4776	broad.mit.edu	37	14	24842414	24842414	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:24842414T>C	uc010tol.1	+	c.1586T>C	c.(1585-1587)ATG>ACG	p.M529T	NFATC4_uc010tok.1_Missense_Mutation_p.M529T|NFATC4_uc010alr.2_Missense_Mutation_p.M529T|NFATC4_uc010als.2_Missense_Mutation_p.M479T|NFATC4_uc010tom.1_Missense_Mutation_p.M479T|NFATC4_uc010ton.1_Missense_Mutation_p.M479T|NFATC4_uc010too.1_Missense_Mutation_p.M479T|NFATC4_uc010alt.2_Missense_Mutation_p.M498T|NFATC4_uc010top.1_Missense_Mutation_p.M498T|NFATC4_uc010toq.1_Missense_Mutation_p.M498T|NFATC4_uc010alu.2_Missense_Mutation_p.M158T|NFATC4_uc001wpc.2_Missense_Mutation_p.M466T|NFATC4_uc010tor.1_Missense_Mutation_p.M466T|NFATC4_uc010tos.1_Missense_Mutation_p.M396T|NFATC4_uc010tot.1_Missense_Mutation_p.M454T|NFATC4_uc010tou.1_Missense_Mutation_p.M396T|NFATC4_uc010tov.1_Missense_Mutation_p.M454T|NFATC4_uc010tow.1_Missense_Mutation_p.M396T|NFATC4_uc010alv.2_Missense_Mutation_p.M454T|NFATC4_uc010tox.1_Missense_Mutation_p.M396T|NFATC4_uc001wpd.2_Missense_Mutation_p.M1T|NFATC4_uc010toy.1_Missense_Mutation_p.M1T|NFATC4_uc010toz.1_Missense_Mutation_p.M1T|NFATC4_uc010tpa.1_5'Flank|NFATC4_uc010tpb.1_5'Flank	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	466	RHD.				cell differentiation|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(265;0.018)										0.210526	9.790406	11.262559	4	15	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	24842414	24842414	10765	14	T	C	C	C	663	51	NFATC4	4	4
LRFN5	145581	broad.mit.edu	37	14	42360569	42360569	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:42360569G>T	uc001wvm.2	+	c.1502G>T	c.(1501-1503)AGA>ATA	p.R501I	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	501	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)										0.293333	56.215294	59.086028	22	53	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	42360569	42360569	9314	14	G	T	T	T	429	33	LRFN5	2	2
FSCB	84075	broad.mit.edu	37	14	44975066	44975066	+	Silent	SNP	A	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:44975066A>T	uc001wvn.2	-	c.1125T>A	c.(1123-1125)TCT>TCA	p.S375S		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	375	Pro-rich.					cilium				breast(3)|ovary(2)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(112;0.128)						151				0.39	225.611729	227.728492	78	122	KEEP	---	---	---	---	capture		Silent	SNP	44975066	44975066	6316	14	A	T	T	T	132	11	FSCB	3	3
GPR65	8477	broad.mit.edu	37	14	88477857	88477857	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:88477857G>C	uc001xvv.2	+	c.666G>C	c.(664-666)AAG>AAC	p.K222N		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	222	Cytoplasmic (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0														0.540984	116.779452	116.868486	33	28	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	88477857	88477857	6981	14	G	C	C	C	425	33	GPR65	3	3
APBA2	321	broad.mit.edu	37	15	29346296	29346296	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:29346296G>T	uc001zck.2	+	c.209G>T	c.(208-210)GGG>GTG	p.G70V	APBA2_uc010azj.2_Missense_Mutation_p.G70V|APBA2_uc010uat.1_Missense_Mutation_p.G70V|APBA2_uc001zcl.2_Missense_Mutation_p.G70V|APBA2_uc010uas.1_Missense_Mutation_p.G70V	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	70					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)										0.313433	53.54423	55.623659	21	46	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	29346296	29346296	767	15	G	T	T	T	559	43	APBA2	2	2
LPCAT4	254531	broad.mit.edu	37	15	34651923	34651923	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:34651923C>A	uc001zig.2	-	c.1266G>T	c.(1264-1266)GAG>GAT	p.E422D		NM_153613	NP_705841	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	422					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding				0														0.351351	32.457888	33.181422	13	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	34651923	34651923	9286	15	C	A	A	A	311	24	LPCAT4	2	2
CATSPER2	117155	broad.mit.edu	37	15	43927614	43927614	+	Silent	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:43927614C>T	uc001zsh.2	-	c.1122G>A	c.(1120-1122)AGG>AGA	p.R374R	CATSPER2_uc010bdm.2_Non-coding_Transcript|CATSPER2_uc001zsi.2_Silent_p.R374R|CATSPER2_uc001zsj.2_Silent_p.R374R	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	374	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)										0.277108	57.533619	61.21788	23	60	KEEP	---	---	---	---	capture		Silent	SNP	43927614	43927614	2807	15	C	T	T	T	389	30	CATSPER2	2	2
LCTL	197021	broad.mit.edu	37	15	66850175	66850175	+	Silent	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:66850175G>A	uc002aqc.2	-	c.807C>T	c.(805-807)GAC>GAT	p.D269D	LCTL_uc002aqd.3_Silent_p.D96D|LCTL_uc010bhw.2_5'UTR	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	269	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2														0.415493	170.094447	170.98098	59	83	KEEP	---	---	---	---	capture		Silent	SNP	66850175	66850175	9018	15	G	A	A	A	620	48	LCTL	2	2
DNAH3	55567	broad.mit.edu	37	16	21062989	21062989	+	Splice_Site_SNP	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:21062989A>G	uc010vbe.1	-	c.4238_splice	c.e29+1	p.R1413_splice		NM_017539	NP_060009			dynein, axonemal, heavy chain 3						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(10)|large_intestine(2)|central_nervous_system(2)	14				GBM - Glioblastoma multiforme(48;0.207)										0.426667	107.494657	107.844972	32	43	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	21062989	21062989	4786	16	A	G	G	G	182	14	DNAH3	5	4
CDH13	1012	broad.mit.edu	37	16	83251006	83251006	+	Silent	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:83251006G>A	uc002fgx.2	+	c.540G>A	c.(538-540)GTG>GTA	p.V180V	CDH13_uc010vns.1_Silent_p.V227V|CDH13_uc010vnt.1_5'UTR|CDH13_uc010vnu.1_Silent_p.V141V	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	180	Cadherin 1.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)										0.517857	95.27518	95.290618	29	27	KEEP	---	---	---	---	capture		Silent	SNP	83251006	83251006	3228	16	G	A	A	A	600	47	CDH13	2	2
MYH3	4621	broad.mit.edu	37	17	10541666	10541666	+	Silent	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:10541666G>T	uc002gmq.1	-	c.3423C>A	c.(3421-3423)GCC>GCA	p.A1141A		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1141	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(1)|pancreas(1)	6														0.28	15.815713	16.903838	7	18	KEEP	---	---	---	---	capture		Silent	SNP	10541666	10541666	10431	17	G	T	T	T	548	43	MYH3	2	2
NF1	4763	broad.mit.edu	37	17	29548866	29548866	+	Splice_Site_SNP	SNP	A	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:29548866A>T	uc002hgg.2	+	c.1642_splice	c.e15-2	p.A548_splice	NF1_uc002hgf.1_Splice_Site_SNP_p.A548_splice|NF1_uc002hgh.2_Splice_Site_SNP_p.A548_splice|NF1_uc010csn.1_Splice_Site_SNP_p.A408_splice	NM_001042492	NP_001035957			neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(155)|central_nervous_system(56)|large_intestine(27)|lung(19)|haematopoietic_and_lymphoid_tissue(13)|ovary(12)|autonomic_ganglia(7)|skin(3)|stomach(2)|breast(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	300		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)						847	TCGA GBM(6;<1E-8)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0.409091	29.471434	29.630173	9	13	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	29548866	29548866	10756	17	A	T	T	T	91	7	NF1	5	3
ITGAE	3682	broad.mit.edu	37	17	3662735	3662735	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:3662735C>T	uc002fwo.3	-	c.827G>A	c.(826-828)GGG>GAG	p.G276E		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	276	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		NSCLC(182;635 2928 8995 38788)				37				0.672131	137.186062	138.786105	41	20	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	3662735	3662735	8189	17	C	T	T	T	286	22	ITGAE	2	2
MYBBP1A	10514	broad.mit.edu	37	17	4445980	4445980	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:4445980G>T	uc002fxz.3	-	c.2949C>A	c.(2947-2949)AGC>AGA	p.S983R	MYBBP1A_uc002fyb.3_Missense_Mutation_p.S983R|MYBBP1A_uc002fya.3_5'Flank|MYBBP1A_uc010vsa.1_Missense_Mutation_p.S25R	NM_001105538	NP_001099008	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 1	983					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2														0.069767	-1.810457	6.408893	3	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	4445980	4445980	10403	17	G	T	T	T	438	34	MYBBP1A	2	2
MRPS23	51649	broad.mit.edu	37	17	55927331	55927331	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:55927331G>C	uc002ivc.2	-	c.41C>G	c.(40-42)TCT>TGT	p.S14C		NM_016070	NP_057154	Q9Y3D9	RT23_HUMAN	mitochondrial ribosomal protein S23	14					translation	intermediate filament cytoskeleton|mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome				0	Breast(9;8.75e-08)													1	8.577235	8.354065	2	0	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	55927331	55927331	10227	17	G	C	C	C	429	33	MRPS23	3	3
TP53	7157	broad.mit.edu	37	17	7578190	7578190	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:7578190T>C	uc002gim.2	-	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(194)|p.Y220S(9)|p.0?(6)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.Y220H(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		Pancreas(47;798 1329 9957 10801)		111	p.Y220C(HCC2935-Tumor)|p.Y220C(BXPC3-Tumor)|p.Y220C(HCC366-Tumor)|p.Y220C(TE8-Tumor)|p.Y220C(NUGC3-Tumor)|p.Y220C(HUH7-Tumor)|p.Y220C(COV362-Tumor)|p.Y220C(HCC1419-Tumor)|p.Y220C(MFE319-Tumor)|p.Y220C(T3M4-Tumor)|p.Y220C(NCIH2342-Tumor)|p.Y220C(MFE296-Tumor)	690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.52	89.155891	89.173572	26	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	7578190	7578190	16923	17	T	C	C	C	637	49	TP53	4	4
SERPINB11	89778	broad.mit.edu	37	18	61390496	61390496	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:61390496G>A	uc002ljk.3	+	c.1042G>A	c.(1042-1044)GCA>ACA	p.A348T	SERPINB11_uc010xes.1_Missense_Mutation_p.A173T|SERPINB11_uc010dqd.2_Intron|SERPINB11_uc002ljj.3_Missense_Mutation_p.A234T|SERPINB11_uc010dqe.2_Missense_Mutation_p.A147T|SERPINB11_uc010dqf.2_Missense_Mutation_p.A146T	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	348	RCL (By similarity).				regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				Ovarian(27;496 784 5942 8975 23930)								0.618785	375.03222	377.270389	112	69	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	61390496	61390496	14586	18	G	A	A	A	442	34	SERPINB11	2	2
ZNF208	7757	broad.mit.edu	37	19	22154763	22154763	+	Nonsense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:22154763C>A	uc002nqp.2	-	c.2689G>T	c.(2689-2691)GGA>TGA	p.G897*	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)	5		all_lung(12;0.0961)|Lung NSC(12;0.103)												0.462687	94.217538	94.29885	31	36	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	22154763	22154763	18357	19	C	A	A	A	273	21	ZNF208	5	2
KIAA0355	9710	broad.mit.edu	37	19	34791651	34791651	+	Silent	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:34791651C>T	uc002nvd.3	+	c.273C>T	c.(271-273)TGC>TGT	p.C91C	KIAA0355_uc010edk.1_Silent_p.C81C	NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	91										ovary(1)	1	Esophageal squamous(110;0.162)													0.545455	38.102237	38.141901	12	10	KEEP	---	---	---	---	capture		Silent	SNP	34791651	34791651	8477	19	C	T	T	T	337	26	KIAA0355	2	2
FPR1	2357	broad.mit.edu	37	19	52250113	52250113	+	Silent	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:52250113C>G	uc002pxq.2	-	c.135G>C	c.(133-135)GGG>GGC	p.G45G		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	45	Helical; Name=1; (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)	1		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)									0.38961	94.237037	95.057	30	47	KEEP	---	---	---	---	capture		Silent	SNP	52250113	52250113	6284	19	C	G	G	G	327	26	FPR1	3	3
HSPBP1	23640	broad.mit.edu	37	19	55789091	55789091	+	Nonsense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:55789091C>A	uc002qjx.2	-	c.472G>T	c.(472-474)GAG>TAG	p.E158*	HSPBP1_uc002qjy.2_Nonsense_Mutation_p.E112*|HSPBP1_uc002qkb.2_Nonsense_Mutation_p.E112*|HSPBP1_uc002qka.2_Nonsense_Mutation_p.E112*|HSPBP1_uc002qkd.2_Nonsense_Mutation_p.E112*|HSPBP1_uc002qkc.2_Nonsense_Mutation_p.E112*	NM_012267	NP_036399	Q9NZL4	HPBP1_HUMAN	hsp70-interacting protein	115					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)										0.666667	6.351308	6.424323	2	1	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	55789091	55789091	7726	19	C	A	A	A	403	31	HSPBP1	5	1
ZIM2	23619	broad.mit.edu	37	19	57286884	57286884	+	Missense_Mutation	SNP	A	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:57286884A>T	uc002qnr.2	-	c.756T>A	c.(754-756)GAT>GAA	p.D252E	ZIM2_uc010ygq.1_Missense_Mutation_p.D48E|ZIM2_uc010ygr.1_Missense_Mutation_p.D48E|ZIM2_uc002qnq.2_Missense_Mutation_p.D252E|ZIM2_uc010etp.2_Missense_Mutation_p.D252E|ZIM2_uc010ygs.1_Missense_Mutation_p.D252E	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)										0.387097	73.786893	74.478997	24	38	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57286884	57286884	18275	19	A	T	T	T	102	8	ZIM2	3	3
USP29	57663	broad.mit.edu	37	19	57640645	57640645	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:57640645A>G	uc002qny.2	+	c.602A>G	c.(601-603)AAA>AGA	p.K201R		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	201					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			ovary(2)|breast(2)|pancreas(1)	5		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)										0.272727	43.546241	46.078948	15	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57640645	57640645	17623	19	A	G	G	G	13	1	USP29	4	4
PTCHD2	57540	broad.mit.edu	37	1	11574578	11574578	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:11574578G>C	uc001ash.3	+	c.1448G>C	c.(1447-1449)TGC>TCC	p.C483S	PTCHD2_uc001asi.1_Missense_Mutation_p.C483S	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	483	SSD.|Helical; (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)										0.294118	29.840135	31.127778	10	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	11574578	11574578	13187	1	G	C	C	C	598	46	PTCHD2	3	3
PRAMEF12	390999	broad.mit.edu	37	1	12835027	12835027	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:12835027C>A	uc001aui.2	+	c.17C>A	c.(16-18)CCA>CAA	p.P6Q		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	6										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)										0.3125	54.776856	56.779825	20	44	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	12835027	12835027	12864	1	C	A	A	A	273	21	PRAMEF12	2	2
LCE4A	199834	broad.mit.edu	37	1	152681701	152681701	+	Nonsense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:152681701C>A	uc001fak.2	+	c.150C>A	c.(148-150)TGC>TGA	p.C50*		NM_178356	NP_848133	Q5TA78	LCE4A_HUMAN	late cornified envelope 4A	50	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.116)											0.807692	331.433267	342.936279	105	25	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	152681701	152681701	8997	1	C	A	A	A	363	28	LCE4A	5	2
LCE1B	353132	broad.mit.edu	37	1	152785173	152785173	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:152785173G>T	uc001faq.2	+	c.251G>T	c.(250-252)AGG>ATG	p.R84M		NM_178349	NP_848126	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	84	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)											0.659341	181.184164	183.21736	60	31	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	152785173	152785173	8983	1	G	T	T	T	455	35	LCE1B	2	2
S100A4	6275	broad.mit.edu	37	1	153516257	153516257	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:153516257T>C	uc001fby.2	-	c.284A>G	c.(283-285)GAT>GGT	p.D95G	S100A5_uc001fbx.2_5'Flank|S100A4_uc001fbz.2_Missense_Mutation_p.D95G	NM_019554	NP_062427	P26447	S10A4_HUMAN	S100 calcium-binding protein A4	95					epithelial to mesenchymal transition|positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus|perinuclear region of cytoplasm	calcium ion binding|RAGE receptor binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)											0.492754	221.796345	221.80261	68	70	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	153516257	153516257	14260	1	T	C	C	C	650	50	S100A4	4	4
C1orf104	284618	broad.mit.edu	37	1	155291221	155291221	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:155291221C>T	uc001fki.2	-	c.59G>A	c.(58-60)GGG>GAG	p.G20E	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_Non-coding_Transcript|RUSC1_uc001fkj.2_Intron|RUSC1_uc001fkk.2_Intron|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank	NM_001039517	NP_001034606	Q66K80	CA104_HUMAN	hypothetical protein LOC284618	20											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)											0.310345	24.364929	25.293797	9	20	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	155291221	155291221	2045	1	C	T	T	T	286	22	C1orf104	2	2
RIT1	6016	broad.mit.edu	37	1	155880486	155880486	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:155880486T>C	uc001fmh.1	-	c.67A>G	c.(67-69)AAA>GAA	p.K23E	RIT1_uc010pgr.1_Intron	NM_006912	NP_008843	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	23					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)											0.525896	408.414817	408.574199	132	119	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	155880486	155880486	13863	1	T	C	C	C	819	63	RIT1	4	4
FCRL2	79368	broad.mit.edu	37	1	157716540	157716540	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:157716540C>A	uc001fre.2	-	c.1513G>T	c.(1513-1515)GTG>TTG	p.V505L	FCRL2_uc001frd.2_Missense_Mutation_p.V252L|FCRL2_uc010phz.1_Silent_p.L444L|FCRL2_uc009wsp.2_Missense_Mutation_p.V199L	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	505	Cytoplasmic (Potential).|ITIM motif 4.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)											0.121951	12.587362	24.072067	10	72	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	157716540	157716540	6032	1	C	A	A	A	221	17	FCRL2	2	2
TMCO4	255104	broad.mit.edu	37	1	20097886	20097886	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:20097886C>A	uc001bcn.2	-	c.269G>T	c.(268-270)GGC>GTC	p.G90V	TMCO4_uc001bcm.2_Missense_Mutation_p.G90V|TMCO4_uc001bco.1_Missense_Mutation_p.G90V|TMCO4_uc001bcp.1_Missense_Mutation_p.G90V|TMCO4_uc009vpn.1_Missense_Mutation_p.G90V|TMCO4_uc001bcq.1_Missense_Mutation_p.G90V	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	90						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)										0.156863	12.164851	17.899618	8	43	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20097886	20097886	16528	1	C	A	A	A	338	26	TMCO4	2	2
MTR	4548	broad.mit.edu	37	1	236988655	236988655	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:236988655G>T	uc001hyi.3	+	c.883G>T	c.(883-885)GGT>TGT	p.G295C	MTR_uc010pxw.1_5'UTR|MTR_uc010pxx.1_Missense_Mutation_p.G295C|MTR_uc010pxy.1_Missense_Mutation_p.G295C|MTR_uc009xgj.1_Intron	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	295	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)									0.259259	221.040847	238.054433	84	240	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	236988655	236988655	10351	1	G	T	T	T	611	47	MTR	2	2
WDR64	128025	broad.mit.edu	37	1	241959664	241959664	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:241959664C>A	uc001hzf.1	+	c.1813C>A	c.(1813-1815)CGT>AGT	p.R605S	WDR64_uc001hzg.1_Missense_Mutation_p.R518S	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	1052											0	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)											0.131148	13.063241	21.129089	8	53	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	241959664	241959664	17888	1	C	A	A	A	247	19	WDR64	1	1
GJB5	2709	broad.mit.edu	37	1	35223435	35223435	+	Silent	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:35223435A>G	uc001bxu.2	+	c.504A>G	c.(502-504)CCA>CCG	p.P168P	GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	168	Extracellular (Potential).				cell communication|epidermis development	connexon complex|integral to membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)												0.333333	35.965869	36.923366	13	26	KEEP	---	---	---	---	capture		Silent	SNP	35223435	35223435	6679	1	A	G	G	G	93	8	GJB5	4	4
GJB5	2709	broad.mit.edu	37	1	35223474	35223474	+	Silent	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:35223474A>G	uc001bxu.2	+	c.543A>G	c.(541-543)TCA>TCG	p.S181S	GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	181	Extracellular (Potential).				cell communication|epidermis development	connexon complex|integral to membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)												0.181818	12.329819	15.469249	6	27	KEEP	---	---	---	---	capture		Silent	SNP	35223474	35223474	6679	1	A	G	G	G	80	7	GJB5	4	4
GJB5	2709	broad.mit.edu	37	1	35223718	35223718	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:35223718C>T	uc001bxu.2	+	c.787C>T	c.(787-789)CGC>TGC	p.R263C	GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	263	Cytoplasmic (Potential).				cell communication|epidermis development	connexon complex|integral to membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)												0.375	45.321549	45.867708	15	25	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	35223718	35223718	6679	1	C	T	T	T	299	23	GJB5	1	1
TOE1	114034	broad.mit.edu	37	1	45807214	45807214	+	Silent	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:45807214C>T	uc009vxq.2	+	c.306C>T	c.(304-306)CTC>CTT	p.L102L	MUTYH_uc001cnf.2_5'Flank|MUTYH_uc009vxo.2_5'Flank|MUTYH_uc001cng.2_5'Flank|MUTYH_uc001cnj.2_5'Flank|MUTYH_uc001cni.2_5'Flank|MUTYH_uc001cnh.2_5'Flank|MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_Non-coding_Transcript|TOE1_uc010olm.1_Intron|TOE1_uc010oln.1_Silent_p.L108L|TOE1_uc001cnr.3_Non-coding_Transcript	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	102						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)									28				0.25	9.091437	10.001575	4	12	KEEP	---	---	---	---	capture		Silent	SNP	45807214	45807214	16890	1	C	T	T	T	392	31	TOE1	1	1
USP33	23032	broad.mit.edu	37	1	78187556	78187556	+	Silent	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:78187556T>C	uc001dht.2	-	c.1710A>G	c.(1708-1710)CAA>CAG	p.Q570Q	USP33_uc001dhs.2_Silent_p.Q291Q|USP33_uc001dhu.2_Silent_p.Q539Q|USP33_uc001dhv.2_Silent_p.Q375Q|USP33_uc001dhw.2_Silent_p.Q562Q	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	570					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1						Melanoma(152;72 1870 11110 26780 42647)								0.305556	31.18088	32.414542	11	25	KEEP	---	---	---	---	capture		Silent	SNP	78187556	78187556	17628	1	T	C	C	C	725	56	USP33	4	4
C20orf70	140683	broad.mit.edu	37	20	31760818	31760818	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:31760818G>A	uc002wyo.1	+	c.238G>A	c.(238-240)GAA>AAA	p.E80K		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	chromosome 20 open reading frame 70 precursor	80						extracellular region	lipid binding			ovary(1)	1														0.571429	50.101663	50.225915	16	12	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	31760818	31760818	2196	20	G	A	A	A	533	41	C20orf70	2	2
CHGB	1114	broad.mit.edu	37	20	5903748	5903748	+	Missense_Mutation	SNP	A	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:5903748A>T	uc002wmg.2	+	c.958A>T	c.(958-960)AGT>TGT	p.S320C	CHGB_uc010zqz.1_Missense_Mutation_p.S3C	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	320						extracellular space	hormone activity			breast(3)|ovary(1)	4														0.384615	110.511722	111.570978	35	56	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	5903748	5903748	3473	20	A	T	T	T	91	7	CHGB	3	3
CHGB	1114	broad.mit.edu	37	20	5903866	5903866	+	Nonsense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:5903866G>A	uc002wmg.2	+	c.1076G>A	c.(1075-1077)TGG>TAG	p.W359*	CHGB_uc010zqz.1_Nonsense_Mutation_p.W42*	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	359						extracellular space	hormone activity			breast(3)|ovary(1)	4														0.085714	3.68793	34.142603	15	160	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	5903866	5903866	3473	20	G	A	A	A	611	47	CHGB	5	2
PLCB1	23236	broad.mit.edu	37	20	8626754	8626754	+	Nonsense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:8626754G>A	uc002wnb.2	+	c.390G>A	c.(388-390)TGG>TGA	p.W130*	PLCB1_uc010zrb.1_Nonsense_Mutation_p.W29*|PLCB1_uc010gbv.1_Nonsense_Mutation_p.W130*|PLCB1_uc002wmz.1_Nonsense_Mutation_p.W130*|PLCB1_uc002wna.2_Nonsense_Mutation_p.W130*|PLCB1_uc002wnc.1_Nonsense_Mutation_p.W29*	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	130					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of gene-specific transcription|negative regulation of monocyte extravasation|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of gene-specific transcription|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity|transcription repressor activity			ovary(4)|breast(3)|lung(1)	8														0.151515	8.652697	12.491478	5	28	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	8626754	8626754	12453	20	G	A	A	A	533	41	PLCB1	5	2
KRTAP13-2	337959	broad.mit.edu	37	21	31744328	31744328	+	Silent	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:31744328C>G	uc002ynz.3	-	c.204G>C	c.(202-204)ACG>ACC	p.T68T		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	68	3.|5 X 10 AA approximate repeats.					intermediate filament					0														0.505747	145.403626	145.406318	44	43	KEEP	---	---	---	---	capture		Silent	SNP	31744328	31744328	8838	21	C	G	G	G	236	19	KRTAP13-2	3	3
KLF11	8462	broad.mit.edu	37	2	10188051	10188051	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:10188051G>T	uc002raf.1	+	c.587G>T	c.(586-588)CGG>CTG	p.R196L	KLF11_uc010yjc.1_Missense_Mutation_p.R179L	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	196					apoptosis|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	promoter binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		Melanoma(56;431 1507 23687 50789)								0.213115	65.406154	74.665682	26	96	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10188051	10188051	8651	2	G	T	T	T	507	39	KLF11	1	1
IL1RL1	9173	broad.mit.edu	37	2	102965694	102965694	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:102965694C>A	uc002tbu.1	+	c.1273C>A	c.(1273-1275)CTA>ATA	p.L425I	IL18R1_uc002tbw.3_Intron	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	425	TIR.|Cytoplasmic (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			ovary(1)|central_nervous_system(1)|skin(1)	3														0.47191	129.142198	129.203417	42	47	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	102965694	102965694	7964	2	C	A	A	A	363	28	IL1RL1	2	2
GTDC1	79712	broad.mit.edu	37	2	144728256	144728256	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:144728256C>T	uc002tvp.2	-	c.949G>A	c.(949-951)GTG>ATG	p.V317M	GTDC1_uc002tvo.2_Missense_Mutation_p.V317M|GTDC1_uc002tvq.2_Missense_Mutation_p.V199M|GTDC1_uc002tvr.2_Intron|GTDC1_uc010fnn.2_Missense_Mutation_p.V317M|GTDC1_uc002tvs.2_Missense_Mutation_p.V285M|GTDC1_uc010fno.2_Missense_Mutation_p.V188M	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	317					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)										0.303371	74.091786	77.163011	27	62	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	144728256	144728256	7131	2	C	T	T	T	247	19	GTDC1	1	1
ZNF804A	91752	broad.mit.edu	37	2	185801643	185801643	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:185801643G>A	uc002uph.2	+	c.1520G>A	c.(1519-1521)GGA>GAA	p.G507E		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	507						intracellular	zinc ion binding			ovary(6)|large_intestine(1)|pancreas(1)	8														0.320896	120.678566	124.496491	43	91	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	185801643	185801643	18768	2	G	A	A	A	533	41	ZNF804A	2	2
ASNSD1	54529	broad.mit.edu	37	2	190531044	190531044	+	Silent	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:190531044C>G	uc002uqt.2	+	c.186C>G	c.(184-186)ACC>ACG	p.T62T		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	62	Glutamine amidotransferase type-2.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)											0.338235	58.094699	59.672728	23	45	KEEP	---	---	---	---	capture		Silent	SNP	190531044	190531044	1068	2	C	G	G	G	275	22	ASNSD1	3	3
HECW2	57520	broad.mit.edu	37	2	197081790	197081790	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:197081790C>A	uc002utm.1	-	c.4436G>T	c.(4435-4437)CGG>CTG	p.R1479L	HECW2_uc002utl.1_Missense_Mutation_p.R1123L	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1479	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			ovary(5)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	9														0.252874	58.828107	63.639255	22	65	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	197081790	197081790	7326	2	C	A	A	A	299	23	HECW2	1	1
APOB	338	broad.mit.edu	37	2	21225814	21225814	+	Silent	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:21225814G>A	uc002red.2	-	c.12480C>T	c.(12478-12480)GGC>GGT	p.G4160G		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4160					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus|very-low-density lipoprotein particle assembly	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|central_nervous_system(3)|large_intestine(2)|pancreas(1)|skin(1)	18	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)									0.288136	39.382752	41.739599	17	42	KEEP	---	---	---	---	capture		Silent	SNP	21225814	21225814	796	2	G	A	A	A	535	42	APOB	2	2
APOB	338	broad.mit.edu	37	2	21229634	21229634	+	Nonsense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:21229634G>T	uc002red.2	-	c.10106C>A	c.(10105-10107)TCA>TAA	p.S3369*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3369					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus|very-low-density lipoprotein particle assembly	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|central_nervous_system(3)|large_intestine(2)|pancreas(1)|skin(1)	18	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)									0.303371	68.700286	71.767104	27	62	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	21229634	21229634	796	2	G	T	T	T	585	45	APOB	5	2
DGKD	8527	broad.mit.edu	37	2	234363425	234363425	+	Missense_Mutation	SNP	A	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:234363425A>C	uc002vui.1	+	c.2281A>C	c.(2281-2283)AAA>CAA	p.K761Q	DGKD_uc002vuj.1_Missense_Mutation_p.K717Q|DGKD_uc010fyh.1_Missense_Mutation_p.K628Q|DGKD_uc010fyi.1_Non-coding_Transcript	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	761					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)									0.214286	22.24398	25.424051	9	33	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	234363425	234363425	4646	2	A	C	C	C	117	9	DGKD	4	4
HJURP	55355	broad.mit.edu	37	2	234749348	234749348	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:234749348C>A	uc002vvg.2	-	c.2078G>T	c.(2077-2079)CGC>CTC	p.R693L	HJURP_uc010znd.1_Missense_Mutation_p.R632L|HJURP_uc010zne.1_Missense_Mutation_p.R601L	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	693					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)										0.298701	63.999603	66.785678	23	54	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	234749348	234749348	7480	2	C	A	A	A	351	27	HJURP	1	1
CENPA	1058	broad.mit.edu	37	2	27016112	27016112	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:27016112C>T	uc002rhr.2	+	c.388C>T	c.(388-390)CGG>TGG	p.R130W	CENPA_uc002rht.2_Non-coding_Transcript|CENPA_uc002rhs.2_Missense_Mutation_p.R104W	NM_001809	NP_001800	P49450	CENPA_HUMAN	centromere protein A isoform a	130	H3-like.				CenH3-containing nucleosome assembly at centromere|establishment of mitotic spindle orientation|interspecies interaction between organisms|kinetochore assembly|mitotic prometaphase|protein localization to chromosome, centromeric region	condensed nuclear chromosome kinetochore|cytosol|nucleoplasm|nucleosome	chromatin binding|DNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					Pancreas(28;769 878 30250 30578 41330)								0.285714	60.227619	63.394753	22	55	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	27016112	27016112	3359	2	C	T	T	T	295	23	CENPA	1	1
ZBTB20	26137	broad.mit.edu	37	3	114069589	114069589	+	Missense_Mutation	SNP	T	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:114069589T>A	uc003ebi.2	-	c.1336A>T	c.(1336-1338)ATC>TTC	p.I446F	ZBTB20_uc003ebj.2_Missense_Mutation_p.I373F|ZBTB20_uc010hqp.2_Missense_Mutation_p.I373F|ZBTB20_uc003ebk.2_Missense_Mutation_p.I373F|ZBTB20_uc003ebl.2_Missense_Mutation_p.I373F|ZBTB20_uc003ebm.2_Missense_Mutation_p.I373F|ZBTB20_uc003ebn.2_Missense_Mutation_p.I373F	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		NSCLC(69;748 1344 9802 11203 30933)								0.5	84.324832	84.324832	27	27	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	114069589	114069589	18115	3	T	A	A	A	637	49	ZBTB20	3	3
DBR1	51163	broad.mit.edu	37	3	137886025	137886025	+	Silent	SNP	T	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:137886025T>A	uc003erv.2	-	c.612A>T	c.(610-612)ACA>ACT	p.T204T	DBR1_uc003eru.2_Silent_p.T153T|DBR1_uc003ert.2_5'Flank	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	204						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0														0.6	72.882399	73.188676	21	14	KEEP	---	---	---	---	capture		Silent	SNP	137886025	137886025	4428	3	T	A	A	A	652	51	DBR1	3	3
PIGX	54965	broad.mit.edu	37	3	196449332	196449332	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:196449332C>T	uc010iaj.2	+	c.100C>T	c.(100-102)CAC>TAC	p.H34Y	PIGX_uc003fwx.3_Missense_Mutation_p.H34Y|PIGX_uc011btx.1_Non-coding_Transcript	NM_017861	NP_060331	Q8TBF5	PIGX_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	75	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00322)										0.6	88.838412	89.272441	30	20	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	196449332	196449332	12327	3	C	T	T	T	325	25	PIGX	2	2
BSN	8927	broad.mit.edu	37	3	49691540	49691540	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:49691540G>T	uc003cxe.3	+	c.4551G>T	c.(4549-4551)ATG>ATT	p.M1517I		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1517					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	zinc ion binding			ovary(5)|central_nervous_system(1)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)										0.518519	41.947837	41.955752	14	13	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	49691540	49691540	1561	3	G	T	T	T	598	46	BSN	2	2
TMF1	7110	broad.mit.edu	37	3	69097285	69097285	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:69097285T>C	uc011bfx.1	-	c.571A>G	c.(571-573)ACT>GCT	p.T191A	TMF1_uc003dnn.2_Missense_Mutation_p.T191A	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	191					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|RNA polymerase II transcription factor activity|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)										0.442623	87.916611	88.091573	27	34	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	69097285	69097285	16768	3	T	C	C	C	780	60	TMF1	4	4
RAD18	56852	broad.mit.edu	37	3	8940671	8940671	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:8940671G>A	uc003brd.2	-	c.1229C>T	c.(1228-1230)CCA>CTA	p.P410L	RAD18_uc003bre.2_Non-coding_Transcript	NM_020165	NP_064550	Q9NS91	RAD18_HUMAN	postreplication repair protein hRAD18p	410					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			skin(3)|ovary(2)	5				OV - Ovarian serous cystadenocarcinoma(96;0.0552)										0.576923	101.757023	102.025124	30	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	8940671	8940671	13439	3	G	A	A	A	611	47	RAD18	2	2
MTTP	4547	broad.mit.edu	37	4	100532530	100532530	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:100532530T>C	uc011cej.1	+	c.1990T>C	c.(1990-1992)TAC>CAC	p.Y664H	MTTP_uc003hvc.3_Missense_Mutation_p.Y637H	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	637	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)									0.25	113.852917	122.713041	39	117	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100532530	100532530	10357	4	T	C	C	C	689	53	MTTP	4	4
ANK2	287	broad.mit.edu	37	4	114274827	114274827	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:114274827G>T	uc003ibe.3	+	c.5053G>T	c.(5053-5055)GAT>TAT	p.D1685Y	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.D1700Y	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1652					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)	13		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)										0.388235	179.558783	181.434722	66	104	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	114274827	114274827	624	4	G	T	T	T	429	33	ANK2	2	2
WDR17	116966	broad.mit.edu	37	4	177061070	177061070	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:177061070G>C	uc003iuj.2	+	c.1459G>C	c.(1459-1461)GCC>CCC	p.A487P	WDR17_uc003iuk.2_Missense_Mutation_p.A463P|WDR17_uc003ium.3_Missense_Mutation_p.A463P|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	487	WD 8.									ovary(2)|pancreas(1)	3		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)										0.163265	33.466253	44.004912	16	82	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	177061070	177061070	17850	4	G	C	C	C	598	46	WDR17	3	3
ZNF721	170960	broad.mit.edu	37	4	436825	436825	+	Silent	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:436825T>C	uc003gaf.3	-	c.1527A>G	c.(1525-1527)CAA>CAG	p.Q509Q	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gag.2_Silent_p.Q477Q|ZNF721_uc010ibe.2_Silent_p.Q465Q	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	477						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1														0.225	23.354153	26.133568	9	31	KEEP	---	---	---	---	capture		Silent	SNP	436825	436825	18719	4	T	C	C	C	673	52	ZNF721	4	4
LRRC66	339977	broad.mit.edu	37	4	52860966	52860966	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:52860966C>A	uc003gzi.2	-	c.2222G>T	c.(2221-2223)GGG>GTG	p.G741V		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	741						integral to membrane				ovary(1)|central_nervous_system(1)	2														0.316901	116.336446	120.564447	45	97	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	52860966	52860966	9393	4	C	A	A	A	286	22	LRRC66	2	2
LPHN3	23284	broad.mit.edu	37	4	62903541	62903541	+	Silent	SNP	T	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:62903541T>A	uc010ihh.2	+	c.3480T>A	c.(3478-3480)TCT>TCA	p.S1160S	LPHN3_uc003hcq.3_Silent_p.S1160S|LPHN3_uc003hct.2_Silent_p.S544S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1138	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3														0.284483	86.726607	91.563871	33	83	KEEP	---	---	---	---	capture		Silent	SNP	62903541	62903541	9290	4	T	A	A	A	691	54	LPHN3	3	3
HERC6	55008	broad.mit.edu	37	4	89358911	89358911	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:89358911A>G	uc011cdi.1	+	c.2533A>G	c.(2533-2535)ATA>GTA	p.I845V	HERC6_uc011cdj.1_Missense_Mutation_p.I809V|HERC6_uc011cdk.1_Non-coding_Transcript|HERC6_uc011cdl.1_Non-coding_Transcript	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	845	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(1)|kidney(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)										0.4375	19.821143	19.87582	7	9	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	89358911	89358911	7345	4	A	G	G	G	104	8	HERC6	4	4
IK	3550	broad.mit.edu	37	5	140037231	140037231	+	Silent	SNP	T	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140037231T>G	uc003lgq.2	+	c.894T>G	c.(892-894)CTT>CTG	p.L298L	IK_uc011czk.1_Silent_p.L298L	NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	298					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.451613	143.646064	143.834747	42	51	KEEP	---	---	---	---	capture		Silent	SNP	140037231	140037231	7909	5	T	G	G	G	782	61	IK	4	4
PCDHB7	56129	broad.mit.edu	37	5	140553994	140553994	+	Silent	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140553994G>T	uc003lit.2	+	c.1578G>T	c.(1576-1578)GCG>GCT	p.A526A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	526	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)											0.081081	1.197523	7.810788	3	34	KEEP	---	---	---	---	capture		Silent	SNP	140553994	140553994	11967	5	G	T	T	T	509	40	PCDHB7	1	1
PCDHB11	56125	broad.mit.edu	37	5	140580679	140580679	+	Silent	SNP	C	A	A	rs35333043		TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140580679C>A	uc003liy.2	+	c.1332C>A	c.(1330-1332)GTC>GTA	p.V444V	PCDHB11_uc011daj.1_Silent_p.V79V	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	444	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)											0.47541	168.217081	168.282622	58	64	KEEP	---	---	---	---	capture		Silent	SNP	140580679	140580679	11956	5	C	A	A	A	366	29	PCDHB11	2	2
TNIP1	10318	broad.mit.edu	37	5	150439923	150439923	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:150439923C>T	uc003ltf.2	-	c.391G>A	c.(391-393)GAG>AAG	p.E131K	TNIP1_uc010jhl.2_Non-coding_Transcript|TNIP1_uc010jhm.2_Missense_Mutation_p.E131K|TNIP1_uc010jhn.2_Missense_Mutation_p.E131K|TNIP1_uc011dco.1_Missense_Mutation_p.E131K|TNIP1_uc003lth.2_Non-coding_Transcript|TNIP1_uc003lti.2_Missense_Mutation_p.E131K|TNIP1_uc003ltg.2_Missense_Mutation_p.E78K|TNIP1_uc003ltj.2_Missense_Mutation_p.E131K|TNIP1_uc010jho.1_Non-coding_Transcript|TNIP1_uc010jhq.1_Missense_Mutation_p.E78K|TNIP1_uc010jhp.1_Missense_Mutation_p.E78K|TNIP1_uc010jhr.1_Missense_Mutation_p.E131K|TNIP1_uc003ltk.2_Missense_Mutation_p.E131K	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	131	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)											0.448276	37.469723	37.537531	13	16	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	150439923	150439923	16855	5	C	T	T	T	377	29	TNIP1	2	2
FYB	2533	broad.mit.edu	37	5	39153585	39153585	+	Silent	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:39153585T>C	uc011cpl.1	-	c.1287A>G	c.(1285-1287)CTA>CTG	p.L429L	FYB_uc003jls.2_Silent_p.L419L|FYB_uc003jlt.2_Silent_p.L419L|FYB_uc003jlu.2_Silent_p.L419L	NM_001465	NP_001456	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 1	419	Interaction with SKAP1.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)											0.36962	472.175677	478.064499	146	249	KEEP	---	---	---	---	capture		Silent	SNP	39153585	39153585	6375	5	T	C	C	C	730	57	FYB	4	4
GPR126	57211	broad.mit.edu	37	6	142689014	142689014	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:142689014C>A	uc010khe.2	+	c.412C>A	c.(412-414)CAG>AAG	p.Q138K	GPR126_uc010khc.2_Missense_Mutation_p.Q138K|GPR126_uc010khd.2_Missense_Mutation_p.Q138K|GPR126_uc010khf.2_Missense_Mutation_p.Q138K|GPR126_uc003qix.2_Missense_Mutation_p.Q138K	NM_198569	NP_940971	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 beta 1 precursor	138	CUB.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)										0.129412	15.577076	26.932938	11	74	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	142689014	142689014	6914	6	C	A	A	A	273	21	GPR126	2	2
OPRM1	4988	broad.mit.edu	37	6	154412190	154412190	+	Silent	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:154412190C>T	uc011efe.1	+	c.1026C>T	c.(1024-1026)ATC>ATT	p.I342I	OPRM1_uc011efc.1_Silent_p.I168I|OPRM1_uc011efd.1_Silent_p.I149I|OPRM1_uc003qpn.2_Silent_p.I249I|OPRM1_uc003qpo.1_Silent_p.I249I|OPRM1_uc011eff.1_Silent_p.I249I|OPRM1_uc011efg.1_Silent_p.I249I|OPRM1_uc011efh.1_Silent_p.I249I|OPRM1_uc003qpq.1_Silent_p.I249I|OPRM1_uc003qpr.2_Silent_p.I249I|OPRM1_uc003qpt.1_Silent_p.I249I|OPRM1_uc011efi.1_Silent_p.I249I|OPRM1_uc003qpp.2_Non-coding_Transcript|OPRM1_uc003qps.2_Non-coding_Transcript|OPRM1_uc010kjg.2_Silent_p.I149I|OPRM1_uc003qpu.2_Silent_p.I149I	NM_001145279	NP_001138751	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1H	249	Helical; Name=5; (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)									0.663158	200.842205	203.075828	63	32	KEEP	---	---	---	---	capture		Silent	SNP	154412190	154412190	11293	6	C	T	T	T	369	29	OPRM1	2	2
SERAC1	84947	broad.mit.edu	37	6	158549153	158549153	+	Silent	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:158549153A>G	uc003qrc.2	-	c.1002T>C	c.(1000-1002)TCT>TCC	p.S334S	SERAC1_uc003qrb.2_Silent_p.S62S	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	334					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)										0.561404	114.005661	114.192824	32	25	KEEP	---	---	---	---	capture		Silent	SNP	158549153	158549153	14560	6	A	G	G	G	184	15	SERAC1	4	4
UNC93A	54346	broad.mit.edu	37	6	167719510	167719510	+	Nonsense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:167719510C>A	uc003qvq.2	+	c.948C>A	c.(946-948)TAC>TAA	p.Y316*	UNC93A_uc003qvr.2_Nonsense_Mutation_p.Y274*	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	316						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)										0.588235	124.200661	124.661589	40	28	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	167719510	167719510	17555	6	C	A	A	A	220	17	UNC93A	5	2
SLC17A1	6568	broad.mit.edu	37	6	25820094	25820094	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:25820094G>T	uc003nfh.3	-	c.257C>A	c.(256-258)TCC>TAC	p.S86Y	SLC17A1_uc011djy.1_Non-coding_Transcript|SLC17A1_uc010jqb.1_Missense_Mutation_p.S84Y|SLC17A1_uc010jqc.1_Missense_Mutation_p.S84Y	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	86	Helical; (Potential).				sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4														0.505556	268.802916	268.807503	91	89	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	25820094	25820094	14912	6	G	T	T	T	533	41	SLC17A1	2	2
OR2B2	81697	broad.mit.edu	37	6	27879546	27879546	+	Silent	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:27879546C>T	uc011dkw.1	-	c.552G>A	c.(550-552)CTG>CTA	p.L184L		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0														0.477679	311.476895	311.575728	107	117	KEEP	---	---	---	---	capture		Silent	SNP	27879546	27879546	11395	6	C	T	T	T	314	25	OR2B2	2	2
ZAN	7455	broad.mit.edu	37	7	100363097	100363097	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:100363097C>A	uc003uwj.2	+	c.4390C>A	c.(4390-4392)CCG>ACG	p.P1464T	ZAN_uc003uwk.2_Missense_Mutation_p.P1464T|ZAN_uc003uwl.2_Non-coding_Transcript|ZAN_uc010lhh.2_Non-coding_Transcript|ZAN_uc010lhi.2_Non-coding_Transcript|ZAN_uc011kkd.1_Missense_Mutation_p.P41T	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1464	TIL 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)											0.176471	5.214258	6.89198	3	14	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100363097	100363097	18096	7	C	A	A	A	390	30	ZAN	2	2
SLC26A4	5172	broad.mit.edu	37	7	107315392	107315392	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:107315392G>T	uc003vep.2	+	c.603G>T	c.(601-603)TTG>TTT	p.L201F		NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	201	Helical; (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)	5														0.33	95.440161	98.002103	33	67	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	107315392	107315392	15016	7	G	T	T	T	581	45	SLC26A4	2	2
WEE2	494551	broad.mit.edu	37	7	141414021	141414021	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:141414021C>T	uc003vwn.2	+	c.355C>T	c.(355-357)CGG>TGG	p.R119W	FLJ40852_uc011krh.1_Non-coding_Transcript|FLJ40852_uc010lnm.2_Non-coding_Transcript|FLJ40852_uc010lnn.2_Non-coding_Transcript|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	119					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|protein phosphorylation|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)									241				0.198718	71.455227	84.621599	31	125	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	141414021	141414021	17919	7	C	T	T	T	295	23	WEE2	1	1
TAS2R38	5726	broad.mit.edu	37	7	141673134	141673134	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:141673134G>T	uc003vwx.1	-	c.356C>A	c.(355-357)TCC>TAC	p.S119Y		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	119	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)	1	Melanoma(164;0.0171)													0.206349	27.471239	32.485136	13	50	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	141673134	141673134	16097	7	G	T	T	T	533	41	TAS2R38	2	2
MLL3	58508	broad.mit.edu	37	7	151945107	151945107	+	Silent	SNP	A	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:151945107A>T	uc003wla.2	-	c.2412T>A	c.(2410-2412)CTT>CTA	p.L804L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	804					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			pancreas(12)|ovary(7)|large_intestine(6)|central_nervous_system(4)|urinary_tract(1)|skin(1)	31	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		Colon(68;14 1149 1884 27689 34759)				1780				0.045894	-53.52999	37.515075	19	395	KEEP	---	---	---	---	capture		Silent	SNP	151945107	151945107	10012	7	A	T	T	T	158	13	MLL3	3	3
PTPRN2	5799	broad.mit.edu	37	7	157691365	157691365	+	Silent	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:157691365C>A	uc011kwa.1	-	c.1857G>T	c.(1855-1857)TCG>TCT	p.S619S	PTPRN2_uc003wno.2_Silent_p.S596S|PTPRN2_uc003wnp.2_Silent_p.S579S|PTPRN2_uc003wnq.2_Silent_p.S567S|PTPRN2_uc003wnr.2_Silent_p.S558S	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	596	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)	6	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)										0.264957	86.483355	92.317731	31	86	KEEP	---	---	---	---	capture		Silent	SNP	157691365	157691365	13265	7	C	A	A	A	288	23	PTPRN2	1	1
DNAH11	8701	broad.mit.edu	37	7	21934331	21934331	+	Missense_Mutation	SNP	T	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:21934331T>A	uc003svc.2	+	c.12862T>A	c.(12862-12864)TAT>AAT	p.Y4288N		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4288					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														0.455357	159.719574	159.912897	51	61	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	21934331	21934331	4781	7	T	A	A	A	637	49	DNAH11	3	3
EEPD1	80820	broad.mit.edu	37	7	36327259	36327259	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:36327259C>G	uc003tfa.2	+	c.1188C>G	c.(1186-1188)CAC>CAG	p.H396Q		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	396					DNA repair|protein secretion	integral to membrane	DNA binding				0														0.067308	-4.816107	15.317628	7	97	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	36327259	36327259	5119	7	C	G	G	G	246	19	EEPD1	3	3
KIAA0895	23366	broad.mit.edu	37	7	36373501	36373501	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:36373501G>A	uc003tfd.2	-	c.1270C>T	c.(1270-1272)CGG>TGG	p.R424W	KIAA0895_uc003tfc.2_Missense_Mutation_p.R411W|KIAA0895_uc011kaw.1_Missense_Mutation_p.R321W|KIAA0895_uc003tfb.2_Missense_Mutation_p.R373W|KIAA0895_uc011kax.1_Missense_Mutation_p.R421W	NM_001100425	NP_001093895	Q8NCT3	K0895_HUMAN	hypothetical protein LOC23366 isoform 1	424											0														0.345238	83.857509	85.630363	29	55	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	36373501	36373501	8504	7	G	A	A	A	519	40	KIAA0895	1	1
GLI3	2737	broad.mit.edu	37	7	42004993	42004993	+	Silent	SNP	T	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:42004993T>A	uc011kbh.1	-	c.3678A>T	c.(3676-3678)CCA>CCT	p.P1226P	GLI3_uc011kbg.1_Silent_p.P1167P	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1226					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of gene-specific transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|transcription activator activity|transcription repressor activity|zinc ion binding			large_intestine(2)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)|pancreas(1)	8										806				0.357143	56.670243	57.682554	20	36	KEEP	---	---	---	---	capture		Silent	SNP	42004993	42004993	6707	7	T	A	A	A	704	55	GLI3	3	3
PEX1	5189	broad.mit.edu	37	7	92131252	92131252	+	Nonsense_Mutation	SNP	G	A	A	rs61750417		TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:92131252G>A	uc003uly.2	-	c.2368C>T	c.(2368-2370)CGA>TGA	p.R790*	PEX1_uc011khr.1_Nonsense_Mutation_p.R582*|PEX1_uc010ley.2_Nonsense_Mutation_p.R733*|PEX1_uc011khs.1_Nonsense_Mutation_p.R468*|PEX1_uc011kht.1_Intron	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	790					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)											0.642105	186.247174	188.002553	61	34	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	92131252	92131252	12157	7	G	A	A	A	480	37	PEX1	5	1
AZGP1	563	broad.mit.edu	37	7	99569388	99569388	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:99569388C>A	uc003ush.2	-	c.318G>T	c.(316-318)GAG>GAT	p.E106D		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	106					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)													0.297872	79.271999	82.700268	28	66	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	99569388	99569388	1260	7	C	A	A	A	259	20	AZGP1	2	2
KCNV1	27012	broad.mit.edu	37	8	110980784	110980784	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:110980784C>A	uc003ynr.3	-	c.1036G>T	c.(1036-1038)GTC>TTC	p.V346F	KCNV1_uc010mcw.2_Missense_Mutation_p.V346F	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	346	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)											0.525	65.97518	65.996833	21	19	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	110980784	110980784	8399	8	C	A	A	A	260	20	KCNV1	2	2
COL14A1	7373	broad.mit.edu	37	8	121219295	121219295	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:121219295G>C	uc003yox.2	+	c.1153G>C	c.(1153-1155)GTT>CTT	p.V385L	COL14A1_uc003yoy.2_Missense_Mutation_p.V63L|COL14A1_uc010mde.1_Missense_Mutation_p.V63L	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	385	Fibronectin type-III 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)							1131				0.2	16.034181	18.543933	6	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	121219295	121219295	3809	8	G	C	C	C	468	36	COL14A1	3	3
ARHGEF10	9639	broad.mit.edu	37	8	1844525	1844525	+	Silent	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:1844525A>G	uc003wpr.2	+	c.1467A>G	c.(1465-1467)GCA>GCG	p.A489A	ARHGEF10_uc003wpq.1_Silent_p.A514A|ARHGEF10_uc003wps.2_Silent_p.A451A|ARHGEF10_uc003wpt.2_Silent_p.A365A|ARHGEF10_uc003wpv.2_Silent_p.A222A|ARHGEF10_uc010lre.2_Silent_p.A169A	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	514	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)						2844				0.47619	30.545435	30.55595	10	11	KEEP	---	---	---	---	capture		Silent	SNP	1844525	1844525	908	8	A	G	G	G	93	8	ARHGEF10	4	4
GPR124	25960	broad.mit.edu	37	8	37672453	37672453	+	Silent	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:37672453C>A	uc003xkj.2	+	c.306C>A	c.(304-306)GGC>GGA	p.G102G	GPR124_uc003xki.2_Silent_p.G102G|GPR124_uc010lvy.2_Silent_p.G102G	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	102	Extracellular (Potential).|LRR 1.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)											0.09375	1.699878	7.009145	3	29	KEEP	---	---	---	---	capture		Silent	SNP	37672453	37672453	6912	8	C	A	A	A	353	28	GPR124	2	2
CHD7	55636	broad.mit.edu	37	8	61750240	61750240	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:61750240G>A	uc003xue.2	+	c.4199G>A	c.(4198-4200)TGT>TAT	p.C1400Y		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1400	Helicase C-terminal.				central nervous system development|chromatin assembly or disassembly|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	chromatin|nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|lung(1)|breast(1)|pancreas(1)	8		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)											0.392857	31.817962	32.099695	11	17	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	61750240	61750240	3464	8	G	A	A	A	624	48	CHD7	2	2
ZNF704	619279	broad.mit.edu	37	8	81582794	81582794	+	Silent	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:81582794C>G	uc003yby.1	-	c.603G>C	c.(601-603)GGG>GGC	p.G201G		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	201	C2H2-type.					intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)											0.653846	112.876232	113.977697	34	18	KEEP	---	---	---	---	capture		Silent	SNP	81582794	81582794	18702	8	C	G	G	G	379	30	ZNF704	3	3
RUNX1T1	862	broad.mit.edu	37	8	92982958	92982958	+	Silent	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:92982958C>A	uc011lgi.1	-	c.1500G>T	c.(1498-1500)ACG>ACT	p.T500T	RUNX1T1_uc003yfc.1_Silent_p.T462T|RUNX1T1_uc003yfd.2_Silent_p.T489T|RUNX1T1_uc003yfe.1_Silent_p.T452T|RUNX1T1_uc010mao.2_Silent_p.T462T|RUNX1T1_uc010man.1_Silent_p.T114T|RUNX1T1_uc003yfb.1_Silent_p.T452T	NM_175636	NP_783554	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	489					generation of precursor metabolites and energy|regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|central_nervous_system(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(11;0.0141)							213				0.681818	48.930497	49.57665	15	7	KEEP	---	---	---	---	capture		Silent	SNP	92982958	92982958	14227	8	C	A	A	A	288	23	RUNX1T1	1	1
RAPGEF1	2889	broad.mit.edu	37	9	134501637	134501637	+	Silent	SNP	G	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:134501637G>A	uc004cbb.2	-	c.1377C>T	c.(1375-1377)GAC>GAT	p.D459D	RAPGEF1_uc004cbc.2_Silent_p.D441D|RAPGEF1_uc010mzm.2_Non-coding_Transcript|RAPGEF1_uc010mzn.2_Silent_p.D446D|RAPGEF1_uc004cbd.2_Silent_p.D446D	NM_198679	NP_941372	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform b	441					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			ovary(2)|lung(1)|skin(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)										0.238095	13.115705	14.396713	5	16	KEEP	---	---	---	---	capture		Silent	SNP	134501637	134501637	13503	9	G	A	A	A	516	40	RAPGEF1	1	1
KIAA0020	9933	broad.mit.edu	37	9	2812306	2812306	+	Silent	SNP	T	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:2812306T>C	uc003zhp.1	-	c.1326A>G	c.(1324-1326)CTA>CTG	p.L442L	KIAA0020_uc010mhc.1_Silent_p.L441L|KIAA0020_uc003zhq.1_Silent_p.L441L	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	442	Pumilio 6.|PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)										0.294118	83.713272	87.580961	30	72	KEEP	---	---	---	---	capture		Silent	SNP	2812306	2812306	8458	9	T	C	C	C	626	49	KIAA0020	4	4
FAM108B1	51104	broad.mit.edu	37	9	74481843	74481843	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:74481843C>A	uc004ail.2	-	c.727G>T	c.(727-729)GGC>TGC	p.G243C	FAM108B1_uc004aim.1_Missense_Mutation_p.G243C	NM_016014	NP_057098	Q5VST6	F108B_HUMAN	family with sequence similarity 108, member B1	243					proteolysis	extracellular region	serine-type peptidase activity				0														0.2	8.787948	10.462661	4	16	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	74481843	74481843	5589	9	C	A	A	A	273	21	FAM108B1	2	2
DAPK1	1612	broad.mit.edu	37	9	90313576	90313576	+	Missense_Mutation	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:90313576G>T	uc004apc.2	+	c.2617G>T	c.(2617-2619)GGT>TGT	p.G873C	DAPK1_uc004apd.2_Missense_Mutation_p.G873C|DAPK1_uc011ltg.1_Missense_Mutation_p.G807C|DAPK1_uc011lth.1_Missense_Mutation_p.G610C	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	873					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade|protein phosphorylation	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2										862				0.215686	28.606023	32.403407	11	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	90313576	90313576	4402	9	G	T	T	T	507	39	DAPK1	1	1
IRS4	8471	broad.mit.edu	37	X	107977313	107977313	+	Silent	SNP	A	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:107977313A>G	uc004eoc.2	-	c.2262T>C	c.(2260-2262)CCT>CCC	p.P754P		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	754	CRK-binding.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|pancreas(1)	9														0.375	83.820302	84.921055	30	50	KEEP	---	---	---	---	capture		Silent	SNP	107977313	107977313	8146	23	A	G	G	G	80	7	IRS4	4	4
IGSF1	3547	broad.mit.edu	37	X	130417145	130417145	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:130417145C>G	uc004ewd.2	-	c.761G>C	c.(760-762)GGA>GCA	p.G254A	IGSF1_uc004ewe.3_Missense_Mutation_p.G243A|IGSF1_uc004ewf.2_Missense_Mutation_p.G234A	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	254	Ig-like C2-type 3.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5														0.48	84.597354	84.614744	24	26	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	130417145	130417145	7897	23	C	G	G	G	390	30	IGSF1	3	3
GPR112	139378	broad.mit.edu	37	X	135485478	135485478	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:135485478C>G	uc004ezu.1	+	c.8651C>G	c.(8650-8652)CCG>CGG	p.P2884R	GPR112_uc010nsb.1_Missense_Mutation_p.P2679R	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2884	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	11	Acute lymphoblastic leukemia(192;0.000127)									487				0.394737	49.2198	49.587388	15	23	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	135485478	135485478	6903	23	C	G	G	G	299	23	GPR112	3	3
TGIF2LX	90316	broad.mit.edu	37	X	89177555	89177555	+	Silent	SNP	G	T	T			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:89177555G>T	uc004efe.2	+	c.471G>T	c.(469-471)CTG>CTT	p.L157L		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	157					regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1														0.444444	36.630681	36.696665	12	15	KEEP	---	---	---	---	capture		Silent	SNP	89177555	89177555	16355	23	G	T	T	T	587	46	TGIF2LX	2	2
OR5B12	390191	broad.mit.edu	37	11	58207392	58207392	+	Frame_Shift_Del	DEL	T	-	-			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:58207392_58207392delT	uc010rkh.1	-	c.233_233delA	c.(232-234)AAGfs	p.K78fs		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	78	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)												0.31			31	70		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	58207392	58207392	11558	11	T	-	-	-	728	56	OR5B12	5	5
TMCO3	55002	broad.mit.edu	37	13	114149925	114149925	+	Frame_Shift_Del	DEL	G	-	-			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:114149925_114149925delG	uc001vtu.3	+	c.29_29delG	c.(28-30)TGGfs	p.W10fs	TMCO3_uc001vtt.3_Frame_Shift_Del_p.W10fs	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	10						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)											0.61			25	16		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	114149925	114149925	16527	13	G	-	-	-	611	47	TMCO3	5	5
POMP	51371	broad.mit.edu	37	13	29238702	29238703	+	Frame_Shift_Ins	INS	-	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:29238702_29238703insG	uc001usf.2	+	c.158_159insG	c.(157-159)AAAfs	p.K53fs		NM_015932	NP_057016	Q9Y244	POMP_HUMAN	proteasome maturation protein	53					proteasome assembly	cytosol|endoplasmic reticulum|membrane|microsome|nucleus|proteasome complex					0		Lung SC(185;0.0367)		all cancers(112;0.141)|OV - Ovarian serous cystadenocarcinoma(117;0.216)										0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	29238702	29238703	12673	13	-	G	G	G	13	1	POMP	5	5
PIGB	9488	broad.mit.edu	37	15	55631503	55631504	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:55631503_55631504delTT	uc002act.2	+	c.833_834delTT	c.(832-834)ATTfs	p.I278fs	PIGB_uc010ugg.1_Frame_Shift_Del_p.I83fs	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	278					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)										0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	55631503	55631504	12309	15	TT	-	-	-	676	52	PIGB	5	5
ADAMTS7	11173	broad.mit.edu	37	15	79059794	79059795	+	Frame_Shift_Ins	INS	-	G	G			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:79059794_79059795insG	uc002bej.3	-	c.2785_2786insC	c.(2785-2787)CGGfs	p.R929fs	ADAMTS7_uc010und.1_Intron	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	929	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0														0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	79059794	79059795	272	15	-	G	G	G	299	23	ADAMTS7	5	5
ACCN1	40	broad.mit.edu	37	17	31618962	31618963	+	Frame_Shift_Ins	INS	-	C	C			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:31618962_31618963insC	uc002hht.2	-	c.171_172insG	c.(169-174)GGGCGGfs	p.G57fs	ACCN1_uc002hhu.2_Intron	NM_183377	NP_899233	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	Error:Variant_position_missing_in_Q16515_after_alignment					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)									0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	31618962	31618963	129	17	-	C	C	C	493	38	ACCN1	5	5
FTSJ3	117246	broad.mit.edu	37	17	61901709	61901709	+	Frame_Shift_Del	DEL	G	-	-			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:61901709_61901709delG	uc002jbz.2	-	c.980_980delC	c.(979-981)GCAfs	p.A327fs	FTSJ3_uc002jca.2_Frame_Shift_Del_p.A327fs	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	327					rRNA methylation	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1														0.31			19	43		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	61901709	61901709	6340	17	G	-	-	-	598	46	FTSJ3	5	5
MUC20	200958	broad.mit.edu	37	3	195452664	195452664	+	Frame_Shift_Del	DEL	C	-	-			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:195452664_195452664delC	uc010hzo.2	+	c.677_677delC	c.(676-678)ACCfs	p.T226fs	MUC20_uc010hzp.2_Frame_Shift_Del_p.T191fs|MUC20_uc011bte.1_Non-coding_Transcript	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	397	12 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-A.|12; approximate.				protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)										0.50			4	4		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	195452664	195452664	10370	3	C	-	-	-	222	18	MUC20	5	5
GPR98	84059	broad.mit.edu	37	5	89923211	89923211	+	Frame_Shift_Del	DEL	G	-	-			TCGA-17-Z044-01	TCGA-17-Z044-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:89923211_89923211delG	uc003kju.2	+	c.856_856delG	c.(856-858)GGAfs	p.G286fs	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	286	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)										0.41			39	57		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	89923211	89923211	6997	5	G	-	-	-	611	47	GPR98	5	5
