Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
GAD2	2572	broad.mit.edu	37	10	26581848	26581848	+	Silent	SNP	C	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:26581848C>A	uc001isp.2	+	c.1512C>A	c.(1510-1512)GTC>GTA	p.V504V	GAD2_uc001isq.2_Silent_p.V504V	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	504					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)	1					L-Glutamic Acid(DB00142)									0.112172	43.710997	105.978634	47	372	KEEP	---	---	---	---	capture		Silent	SNP	26581848	26581848	6431	10	C	A	A	A	405	32	GAD2	2	2
OR5D13	390142	broad.mit.edu	37	11	55541050	55541050	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:55541050G>C	uc010ril.1	+	c.137G>C	c.(136-138)GGC>GCC	p.G46A		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		all_epithelial(135;0.196)												0.117871	42.071596	79.818203	31	232	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	55541050	55541050	11564	11	G	C	C	C	546	42	OR5D13	3	3
MYO1A	4640	broad.mit.edu	37	12	57424944	57424944	+	Silent	SNP	T	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:57424944T>C	uc001smw.3	-	c.2364A>G	c.(2362-2364)CTA>CTG	p.L788L	MYO1A_uc010sqz.1_Silent_p.L626L|MYO1A_uc009zpd.2_Silent_p.L788L	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	788					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|urinary_tract(1)|skin(1)	4														0.145833	51.044138	74.30487	28	164	KEEP	---	---	---	---	capture		Silent	SNP	57424944	57424944	10463	12	T	C	C	C	730	57	MYO1A	4	4
MBNL2	10150	broad.mit.edu	37	13	97999179	97999179	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:97999179A>G	uc010aft.2	+	c.662A>G	c.(661-663)TAC>TGC	p.Y221C	MBNL2_uc001vmz.2_Missense_Mutation_p.Y221C|MBNL2_uc001vna.2_Missense_Mutation_p.Y221C|MBNL2_uc001vnb.2_Non-coding_Transcript|MBNL2_uc010tij.1_Intron|MBNL2_uc001vnc.2_5'Flank	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	221	C3H1-type 4.				mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)											0.245353	190.346032	206.31173	66	203	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	97999179	97999179	9742	13	A	G	G	G	182	14	MBNL2	4	4
AKAP6	9472	broad.mit.edu	37	14	32902910	32902910	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:32902910C>G	uc001wrq.2	+	c.211C>G	c.(211-213)CCT>GCT	p.P71A	AKAP6_uc010aml.2_Missense_Mutation_p.P68A	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	71					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|large_intestine(2)|lung(2)|pancreas(1)	16	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		Melanoma(49;821 1200 7288 13647 42351)				483				0.112033	40.100267	75.891778	27	214	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	32902910	32902910	458	14	C	G	G	G	234	18	AKAP6	3	3
SYT16	83851	broad.mit.edu	37	14	62551035	62551035	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:62551035C>T	uc001xfu.1	+	c.1556C>T	c.(1555-1557)ACG>ATG	p.T519M	SYT16_uc010tse.1_Missense_Mutation_p.T77M	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	519	C2 2.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)										0.246479	79.14068	87.399099	35	107	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	62551035	62551035	15993	14	C	T	T	T	247	19	SYT16	1	1
TUBGCP5	114791	broad.mit.edu	37	15	22868967	22868967	+	Splice_Site_SNP	SNP	G	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:22868967G>C	uc001yuq.2	+	c.2838_splice	c.e20+1	p.K946_splice	TUBGCP5_uc001yur.3_Splice_Site_SNP_p.K946_splice	NM_001102610	NP_001096080			tubulin, gamma complex associated protein 5						G2/M transition of mitotic cell cycle|microtubule nucleation	cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding				0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)										0.153846	8.606007	11.565658	4	22	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	22868967	22868967	17324	15	G	C	C	C	572	44	TUBGCP5	5	3
HERC2	8924	broad.mit.edu	37	15	28386775	28386775	+	Nonsense_Mutation	SNP	G	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:28386775G>A	uc001zbj.2	-	c.11818C>T	c.(11818-11820)CGA>TGA	p.R3940*		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3940	WD 5.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition	anaphase-promoting complex	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(2)|central_nervous_system(1)	11		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)					p.R3940R(RAJI-Tumor)	1580				0.175676	72.109662	94.146743	39	183	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	28386775	28386775	7341	15	G	A	A	A	493	38	HERC2	5	1
DISP2	85455	broad.mit.edu	37	15	40660420	40660420	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:40660420C>G	uc001zlk.1	+	c.2107C>G	c.(2107-2109)CGC>GGC	p.R703G		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	703					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)										0.214286	11.840807	13.947817	6	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	40660420	40660420	4719	15	C	G	G	G	299	23	DISP2	3	3
ITGA11	22801	broad.mit.edu	37	15	68620499	68620499	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:68620499C>A	uc010bib.2	-	c.2003G>T	c.(2002-2004)TGC>TTC	p.C668F	ITGA11_uc002ari.2_Missense_Mutation_p.C668F	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	668	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)									0.082192	-3.762305	8.891207	6	67	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	68620499	68620499	8178	15	C	A	A	A	325	25	ITGA11	2	2
SH2D7	646892	broad.mit.edu	37	15	78393869	78393869	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:78393869C>A	uc010blb.1	+	c.1274C>A	c.(1273-1275)ACC>AAC	p.T425N		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	425											0														0.166667	7.484326	10.01332	4	20	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	78393869	78393869	14730	15	C	A	A	A	234	18	SH2D7	2	2
COQ9	57017	broad.mit.edu	37	16	57493630	57493630	+	Nonsense_Mutation	SNP	C	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:57493630C>T	uc002elq.2	+	c.865C>T	c.(865-867)CAG>TAG	p.Q289*	COQ9_uc002elr.2_Nonsense_Mutation_p.Q254*|COQ9_uc002els.2_Nonsense_Mutation_p.Q82*|POLR2C_uc010vhq.1_5'Flank|POLR2C_uc002elt.1_5'Flank	NM_020312	NP_064708	O75208	COQ9_HUMAN	coenzyme Q9 homolog precursor	289					ubiquinone biosynthetic process	mitochondrion				breast(1)	1														0.178571	25.67862	33.847637	15	69	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	57493630	57493630	3889	16	C	T	T	T	325	25	COQ9	5	2
PRSS54	221191	broad.mit.edu	37	16	58314362	58314362	+	Silent	SNP	C	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:58314362C>T	uc002enf.2	-	c.954G>A	c.(952-954)AGG>AGA	p.R318R	PRSS54_uc002eng.2_Silent_p.R318R|PRSS54_uc010vie.1_Silent_p.R219R|CCDC113_uc002ene.2_3'UTR|CCDC113_uc010vid.1_3'UTR	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	318					proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2														0.15748	34.51335	48.733817	20	107	KEEP	---	---	---	---	capture		Silent	SNP	58314362	58314362	13084	16	C	T	T	T	389	30	PRSS54	2	2
NAE1	8883	broad.mit.edu	37	16	66847735	66847735	+	Silent	SNP	A	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:66847735A>T	uc010cdv.2	-	c.864T>A	c.(862-864)ATT>ATA	p.I288I	NAE1_uc002eqe.2_Silent_p.I279I|NAE1_uc002eqf.2_Silent_p.I285I|NAE1_uc002eqg.2_Silent_p.I196I	NM_001018160	NP_001018170	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform c	285					apoptosis|cell cycle|DNA replication|protein neddylation|S-M checkpoint	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)									0.090909	6.52327	38.102179	17	170	KEEP	---	---	---	---	capture		Silent	SNP	66847735	66847735	10535	16	A	T	T	T	60	5	NAE1	3	3
MYH2	4620	broad.mit.edu	37	17	10432554	10432554	+	Silent	SNP	G	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:10432554G>A	uc010coi.2	-	c.3279C>T	c.(3277-3279)ATC>ATT	p.I1093I	MYH2_uc002gmp.3_Silent_p.I1093I|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1093	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|lung(1)|kidney(1)	11														0.060241	-6.698172	10.087974	5	78	KEEP	---	---	---	---	capture		Silent	SNP	10432554	10432554	10430	17	G	A	A	A	577	45	MYH2	2	2
SLC9A3R1	9368	broad.mit.edu	37	17	72745205	72745205	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:72745205C>A	uc002jlo.2	+	c.220C>A	c.(220-222)CAG>AAG	p.Q74K	SLC9A3R1_uc002jln.1_Non-coding_Transcript	NM_004252	NP_004243	O14745	NHRF1_HUMAN	sodium/hydrogen exchanger regulatory factor 1	74	PDZ 1.				apoptosis|bile acid secretion|glutathione transport|microvillus assembly|negative regulation of cell proliferation|negative regulation of ERK1 and ERK2 cascade|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|protein complex assembly|regulation of protein kinase activity|regulation of sodium:hydrogen antiporter activity|renal absorption|Wnt receptor signaling pathway	actin cytoskeleton|apical plasma membrane|centrosome|endomembrane system|filopodium|intracellular membrane-bounded organelle|microvillus membrane|ruffle	beta-2 adrenergic receptor binding|beta-catenin binding|chloride channel regulator activity|growth factor receptor binding|PDZ domain binding|phosphatase binding|protein self-association				0														0.428571	8.323894	8.354996	3	4	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	72745205	72745205	15211	17	C	A	A	A	325	25	SLC9A3R1	2	2
UNC13A	23025	broad.mit.edu	37	19	17743623	17743623	+	Silent	SNP	G	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:17743623G>A	uc002nhd.2	-	c.3660C>T	c.(3658-3660)CCC>CCT	p.P1220P		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1132	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3														0.179104	25.696948	32.159678	12	55	KEEP	---	---	---	---	capture		Silent	SNP	17743623	17743623	17542	19	G	A	A	A	496	39	UNC13A	1	1
MYBPHL	343263	broad.mit.edu	37	1	109839773	109839773	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:109839773C>T	uc001dxk.1	-	c.469G>A	c.(469-471)GTT>ATT	p.V157I	MYBPHL_uc010ovh.1_Missense_Mutation_p.V134I|MYBPHL_uc001dxl.2_Intron	NM_001010985	NP_001010985	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	157	Fibronectin type-III.									ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)										0.161538	68.492386	96.912826	42	218	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	109839773	109839773	10410	1	C	T	T	T	247	19	MYBPHL	1	1
DENND4B	9909	broad.mit.edu	37	1	153915382	153915382	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:153915382C>T	uc001fdd.1	-	c.542G>A	c.(541-543)CGG>CAG	p.R181Q		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	181	MABP.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)											0.130435	4.509483	7.564796	3	20	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	153915382	153915382	4613	1	C	T	T	T	299	23	DENND4B	1	1
TPM3	7170	broad.mit.edu	37	1	154148674	154148674	+	Silent	SNP	T	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:154148674T>C	uc001fec.1	-	c.294A>G	c.(292-294)GAA>GAG	p.E98E	TPM3_uc010pei.1_Intron|TPM3_uc001fdy.1_Silent_p.E61E|TPM3_uc001fdz.1_Silent_p.E61E|TPM3_uc001fea.1_Silent_p.E61E|TPM3_uc001feb.1_Silent_p.E61E|TPM3_uc010pej.1_Intron|TPM3_uc009wor.2_Intron|TPM3_uc001fed.1_Silent_p.E61E	NM_152263	NP_689476	P06753	TPM3_HUMAN	tropomyosin 3 isoform 1	97	By similarity.				cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/ALK(33)	haematopoietic_and_lymphoid_tissue(22)|soft_tissue(11)	33	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)									241				0.231003	201.956404	223.859838	76	253	KEEP	---	---	---	---	capture		Silent	SNP	154148674	154148674	16951	1	T	C	C	C	725	56	TPM3	4	4
CYB5R1	51706	broad.mit.edu	37	1	202935709	202935709	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:202935709T>C	uc001gyt.2	-	c.185A>G	c.(184-186)AAG>AGG	p.K62R	CYB5R1_uc010pqe.1_Non-coding_Transcript	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	62	FAD-binding FR-type.				oxidation-reduction process|sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)											0.048276	-15.982774	15.470742	7	138	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	202935709	202935709	4291	1	T	C	C	C	728	56	CYB5R1	4	4
HSPG2	3339	broad.mit.edu	37	1	22160319	22160319	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:22160319C>A	uc009vqd.2	-	c.10823G>T	c.(10822-10824)AGC>ATC	p.S3608I	HSPG2_uc001bfj.2_Missense_Mutation_p.S3607I	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3607	Ig-like C2-type 22.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)	8		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)									0.096774	2.001091	7.052567	3	28	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	22160319	22160319	7730	1	C	A	A	A	364	28	HSPG2	2	2
FAAH	2166	broad.mit.edu	37	1	46871356	46871356	+	Silent	SNP	C	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:46871356C>T	uc001cpu.2	+	c.675C>T	c.(673-675)ATC>ATT	p.I225I	FAAH_uc001cpv.2_Non-coding_Transcript	NM_001441	NP_001432	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	225	Cytoplasmic (By similarity).				fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)									0.176471	39.109233	50.856341	21	98	KEEP	---	---	---	---	capture		Silent	SNP	46871356	46871356	5550	1	C	T	T	T	395	31	FAAH	1	1
MSH4	4438	broad.mit.edu	37	1	76363723	76363723	+	Nonsense_Mutation	SNP	T	G	G			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:76363723T>G	uc001dhd.1	+	c.2487T>G	c.(2485-2487)TAT>TAG	p.Y829*		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	829					chiasma assembly|homologous chromosome segregation|meiotic mismatch repair|reciprocal meiotic recombination	mismatch repair complex|synaptonemal complex	ATP binding|damaged DNA binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(1)|lung(1)	2														0.238462	94.569397	102.68276	31	99	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	76363723	76363723	10265	1	T	G	G	G	634	49	MSH4	5	4
SIRPB1	10326	broad.mit.edu	37	20	1552414	1552414	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:1552414G>C	uc010gai.2	-	c.703C>G	c.(703-705)CAG>GAG	p.Q235E	SIRPB1_uc002wfk.3_Intron	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	235	Extracellular (Potential).|Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1														0.378505	252.713996	255.521891	81	133	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	1552414	1552414	14828	20	G	C	C	C	598	46	SIRPB1	3	3
ACSS1	84532	broad.mit.edu	37	20	25038481	25038481	+	Silent	SNP	G	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:25038481G>C	uc002wub.2	-	c.258C>G	c.(256-258)CCC>CCG	p.P86P	ACSS1_uc002wuc.2_Silent_p.P86P|ACSS1_uc010gdc.2_Silent_p.P86P	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	86					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)									0.175439	17.518576	23.180902	10	47	KEEP	---	---	---	---	capture		Silent	SNP	25038481	25038481	189	20	G	C	C	C	444	35	ACSS1	3	3
KIF3B	9371	broad.mit.edu	37	20	30898037	30898037	+	Nonsense_Mutation	SNP	C	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:30898037C>T	uc002wxq.2	+	c.457C>T	c.(457-459)CGA>TGA	p.R153*	KIF3B_uc010ztv.1_Nonsense_Mutation_p.R153*|KIF3B_uc010ztw.1_Nonsense_Mutation_p.R153*	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	153	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|mitotic spindle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)											0.235294	64.662101	71.188192	24	78	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	30898037	30898037	8612	20	C	T	T	T	295	23	KIF3B	5	1
SETD4	54093	broad.mit.edu	37	21	37418122	37418122	+	Nonsense_Mutation	SNP	G	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:37418122G>A	uc002yuw.1	-	c.484C>T	c.(484-486)CAG>TAG	p.Q162*	SETD4_uc002yux.1_Nonsense_Mutation_p.Q138*|SETD4_uc002yuu.2_Non-coding_Transcript|SETD4_uc002yuv.2_Nonsense_Mutation_p.Q162*|SETD4_uc002yuy.2_Nonsense_Mutation_p.Q162*|SETD4_uc002yuz.2_Nonsense_Mutation_p.Q138*|SETD4_uc002yva.2_Nonsense_Mutation_p.Q138*	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	162	SET.									large_intestine(1)|ovary(1)	2														0.170968	88.922594	120.644723	53	257	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	37418122	37418122	14622	21	G	A	A	A	598	46	SETD4	5	2
BRWD1	54014	broad.mit.edu	37	21	40608649	40608649	+	Missense_Mutation	SNP	A	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:40608649A>C	uc002yxk.1	-	c.2638T>G	c.(2638-2640)TTA>GTA	p.L880V	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.L880V|BRWD1_uc010goe.1_Non-coding_Transcript|BRWD1_uc010gof.1_Missense_Mutation_p.L333V|BRWD1_uc010gog.1_Non-coding_Transcript|BRWD1_uc010goh.1_Non-coding_Transcript|BRWD1_uc010goi.1_Missense_Mutation_p.L556V	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	880					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				Melanoma(170;988 1986 4794 16843 39731)								0.198473	70.074621	81.160135	26	105	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	40608649	40608649	1556	21	A	C	C	C	11	1	BRWD1	4	4
ZNF295	49854	broad.mit.edu	37	21	43412010	43412010	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:43412010G>C	uc002zab.3	-	c.2195C>G	c.(2194-2196)TCT>TGT	p.S732C	ZNF295_uc002yzz.3_Intron|ZNF295_uc002yzy.3_Missense_Mutation_p.S732C|ZNF295_uc002zaa.3_Missense_Mutation_p.S732C	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	732					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methyl-CpG binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2														0.169892	196.91782	244.798011	79	386	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43412010	43412010	18419	21	G	C	C	C	429	33	ZNF295	3	3
HMOX1	3162	broad.mit.edu	37	22	35789561	35789561	+	Silent	SNP	G	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:35789561G>A	uc003ant.1	+	c.837G>A	c.(835-837)GCG>GCA	p.A279A		NM_002133	NP_002124	P09601	HMOX1_HUMAN	heme oxygenase (decyclizing) 1	279					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|excretion|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|positive regulation of vasodilation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			ovary(1)	1					NADH(DB00157)									0.035928	-26.98914	12.046029	6	161	KEEP	---	---	---	---	capture		Silent	SNP	35789561	35789561	7535	22	G	A	A	A	470	37	HMOX1	1	1
ALPI	248	broad.mit.edu	37	2	233321775	233321775	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:233321775A>G	uc002vst.3	+	c.467A>G	c.(466-468)AAG>AGG	p.K156R	ALPI_uc002vsu.3_Missense_Mutation_p.K67R	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	156					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)										0.333333	12.696277	12.991346	4	8	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	233321775	233321775	546	2	A	G	G	G	39	3	ALPI	4	4
NEK1	4750	broad.mit.edu	37	4	170498225	170498225	+	Missense_Mutation	SNP	T	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:170498225T>C	uc003isd.1	-	c.874A>G	c.(874-876)AGA>GGA	p.R292G	NEK1_uc003isb.1_Missense_Mutation_p.R292G|NEK1_uc003isc.1_Missense_Mutation_p.R292G|NEK1_uc003ise.1_Missense_Mutation_p.R292G|NEK1_uc003isf.1_Missense_Mutation_p.R292G|NEK1_uc003isg.1_Missense_Mutation_p.R213G	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	292					cell division|cilium assembly|mitosis|protein phosphorylation	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)						366				0.261364	70.986502	75.52005	23	65	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	170498225	170498225	10720	4	T	C	C	C	726	56	NEK1	4	4
NFXL1	152518	broad.mit.edu	37	4	47853119	47853119	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:47853119C>G	uc010igh.2	-	c.2555G>C	c.(2554-2556)AGA>ACA	p.R852T	NFXL1_uc003gxo.2_Missense_Mutation_p.R177T|NFXL1_uc003gxp.2_Missense_Mutation_p.R852T|NFXL1_uc003gxq.3_Non-coding_Transcript|NFXL1_uc010igi.2_Missense_Mutation_p.R852T	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	852	Potential.				regulation of transcription, DNA-dependent	integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1														0.156627	30.626595	39.960092	13	70	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	47853119	47853119	10788	4	C	G	G	G	416	32	NFXL1	3	3
FRAS1	80144	broad.mit.edu	37	4	79400644	79400644	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:79400644G>A	uc003hlb.2	+	c.8215G>A	c.(8215-8217)GCG>ACG	p.A2739T		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2734	Extracellular (Potential).|Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5														0.225564	68.624053	77.800683	30	103	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	79400644	79400644	6288	4	G	A	A	A	494	38	FRAS1	1	1
WDFY3	23001	broad.mit.edu	37	4	85750167	85750167	+	Missense_Mutation	SNP	G	C	C			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:85750167G>C	uc003hpd.2	-	c.946C>G	c.(946-948)CTC>GTC	p.L316V	WDFY3_uc003hpf.2_Missense_Mutation_p.L316V	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	316						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)										0.1	11.73593	29.324864	11	99	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	85750167	85750167	17842	4	G	C	C	C	429	33	WDFY3	3	3
CLPTM1L	81037	broad.mit.edu	37	5	1323907	1323907	+	Silent	SNP	A	G	G			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:1323907A>G	uc003jch.2	-	c.1275T>C	c.(1273-1275)TAT>TAC	p.Y425Y	CLPTM1L_uc003jcg.2_Silent_p.Y256Y	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	425	Extracellular (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)						276				0.083333	1.600391	7.94856	3	33	KEEP	---	---	---	---	capture		Silent	SNP	1323907	1323907	3693	5	A	G	G	G	206	16	CLPTM1L	4	4
PCDHGC4	56098	broad.mit.edu	37	5	140864939	140864939	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140864939G>A	uc003lky.1	+	c.199G>A	c.(199-201)GCT>ACT	p.A67T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.A67T	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	67	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.125714	23.182468	47.091874	22	153	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	140864939	140864939	11990	5	G	A	A	A	494	38	PCDHGC4	1	1
FYB	2533	broad.mit.edu	37	5	39202820	39202820	+	Silent	SNP	C	T	T			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:39202820C>T	uc011cpl.1	-	c.273G>A	c.(271-273)CCG>CCA	p.P91P	FYB_uc003jls.2_Silent_p.P81P|FYB_uc003jlt.2_Silent_p.P81P|FYB_uc003jlu.2_Silent_p.P81P	NM_001465	NP_001456	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 1	81					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)											0.076923	-3.415423	18.028817	9	108	KEEP	---	---	---	---	capture		Silent	SNP	39202820	39202820	6375	5	C	T	T	T	236	19	FYB	1	1
FAM58A	92002	broad.mit.edu	37	X	152860004	152860004	+	Splice_Site_SNP	SNP	C	A	A			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:152860004C>A	uc011myr.1	-	c.421_splice	c.e6+1	p.V141_splice	FAM58A_uc011mys.1_Splice_Site_SNP_p.V141_splice|FAM58A_uc010nug.2_Splice_Site_SNP_p.K81_splice	NM_152274	NP_689487			family with sequence similarity 58, member A								protein binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)													0.272727	92.049508	98.191372	36	96	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	152860004	152860004	5812	23	C	A	A	A	234	18	FAM58A	5	2
AP2A2	161	broad.mit.edu	37	11	1009103	1009104	+	Frame_Shift_Ins	INS	-	G	G			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:1009103_1009104insG	uc001lss.2	+	c.2424_2425insG	c.(2422-2427)TATGGGfs	p.Y808fs		NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	808_809					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)										0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	1009103	1009104	750	11	-	G	G	G	660	51	AP2A2	5	5
IQCK	124152	broad.mit.edu	37	16	19729765	19729769	+	Frame_Shift_Del	DEL	TCACC	-	-			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:19729765_19729769delTCACC	uc002dgr.2	+	c.137_141delTCACC	c.(136-141)GTCACCfs	p.V46fs	IQCK_uc002dgs.2_Non-coding_Transcript|IQCK_uc010vat.1_Frame_Shift_Del_p.V46fs|IQCK_uc010bwc.2_Non-coding_Transcript|IQCK_uc010vau.1_5'UTR|C16orf88_uc002dgq.2_5'Flank	NM_153208	NP_694940	Q8N0W5	IQCK_HUMAN	IQ motif containing K	46_47											0														0.35			8	15		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	19729765	19729769	8116	16	TCACC	-	-	-	754	58	IQCK	5	5
FMN2	56776	broad.mit.edu	37	1	240255569	240255571	+	In_Frame_Del	DEL	GGC	-	-			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:240255569_240255571delGGC	uc010pye.1	+	c.160_162delGGC	c.(160-162)GGCdel	p.G59del	FMN2_uc010pyd.1_In_Frame_Del_p.G59del	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	59					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|large_intestine(1)|central_nervous_system(1)	9	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)							1289				0.36			4	7		---	---	---	---	capture_indel		In_Frame_Del	DEL	240255569	240255571	6192	1	GGC	-	-	-	559	43	FMN2	5	5
ABO	28	broad.mit.edu	37	9	136131057	136131057	+	Frame_Shift_Del	DEL	G	-	-			TCGA-17-Z048-01	TCGA-17-Z048-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:136131057_136131057delG	uc004cda.1	-	c.1061_1061delC	c.(1060-1062)CCGfs	p.P354fs	ABO_uc010naf.1_Frame_Shift_Del_p.P213fs|ABO_uc011mcz.1_Frame_Shift_Del_p.P213fs|ABO_uc010nag.1_Frame_Shift_Del_p.P213fs	NM_020469	NP_065202	P16442	BGAT_HUMAN	ABO blood group (alpha	354	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)										0.43			9	12		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	136131057	136131057	98	9	G	-	-	-	507	39	ABO	5	5
