Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
RAG1	5896	broad.mit.edu	37	11	36595447	36595447	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:36595447G>A	uc001mwu.3	+	c.593G>A	c.(592-594)AGG>AAG	p.R198K	RAG1_uc001mwt.2_Non-coding_Transcript	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	198	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4	all_lung(20;0.226)	all_hematologic(20;0.107)				Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)				117				0.095541	12.803827	38.57296	15	142	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	36595447	36595447	13463	11	G	A	A	A	455	35	RAG1	2	2
NINJ2	4815	broad.mit.edu	37	12	675233	675233	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:675233G>A	uc001qil.2	-	c.283C>T	c.(283-285)CGG>TGG	p.R95W	NINJ2_uc010sdr.1_Missense_Mutation_p.R13W|NINJ2_uc010sds.1_Missense_Mutation_p.R95W	NM_016533	NP_057617	Q9NZG7	NINJ2_HUMAN	ninjurin 2	49	Extracellular (Potential).				nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)											0.085714	0.505436	6.588285	3	32	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	675233	675233	10820	12	G	A	A	A	493	38	NINJ2	1	1
PLCD3	113026	broad.mit.edu	37	17	43194081	43194081	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:43194081C>T	uc002iib.2	-	c.1331G>A	c.(1330-1332)CGC>CAC	p.R444H		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	phospholipase C delta 3	444	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|lung(1)	3					Phosphatidylserine(DB00144)									0.142857	5.016895	7.593049	3	18	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43194081	43194081	12458	17	C	T	T	T	351	27	PLCD3	1	1
DNMT1	1786	broad.mit.edu	37	19	10265690	10265690	+	Missense_Mutation	SNP	G	A	A			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:10265690G>A	uc010xlc.1	-	c.1535C>T	c.(1534-1536)GCG>GTG	p.A512V	DNMT1_uc002mng.2_Missense_Mutation_p.A496V|DNMT1_uc002mnh.2_Missense_Mutation_p.A391V|DNMT1_uc010xld.1_Missense_Mutation_p.A496V	NM_001130823	NP_001124295	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform a	496	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)					705				0.090909	1.001288	6.568151	3	30	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10265690	10265690	4858	19	G	A	A	A	494	38	DNMT1	1	1
ZNF99	7652	broad.mit.edu	37	19	22940442	22940442	+	Missense_Mutation	SNP	C	A	A			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:22940442C>A	uc010xrh.1	-	c.1996G>T	c.(1996-1998)GCA>TCA	p.A666S		NM_001080409	NP_001073878	A8MXY4	ZNF99_HUMAN	zinc finger protein 99	666					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)												0.076923	-0.587017	18.473305	8	96	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	22940442	22940442	18808	19	C	A	A	A	325	25	ZNF99	2	2
CR1	1378	broad.mit.edu	37	1	207762112	207762112	+	Missense_Mutation	SNP	A	G	G			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:207762112A>G	uc001hfx.2	+	c.5803A>G	c.(5803-5805)AAT>GAT	p.N1935D	CR1_uc009xcl.1_Missense_Mutation_p.N1035D|CR1_uc001hfy.2_Missense_Mutation_p.N1485D	NM_000651	NP_000642	P17927	CR1_HUMAN	complement receptor 1 isoform S precursor	1485	Extracellular (Potential).|Sushi 23.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3														0.061224	-4.228395	15.463346	6	92	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	207762112	207762112	3979	1	A	G	G	G	169	13	CR1	4	4
HS3ST1	9957	broad.mit.edu	37	4	11401104	11401104	+	Missense_Mutation	SNP	C	T	T			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:11401104C>T	uc003gmq.2	-	c.526G>A	c.(526-528)GAG>AAG	p.E176K		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	176						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity				0														0.125	8.486266	16.181791	7	49	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	11401104	11401104	7657	4	C	T	T	T	390	30	HS3ST1	2	2
SORBS2	8470	broad.mit.edu	37	4	186539747	186539747	+	Silent	SNP	C	T	T			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:186539747C>T	uc003iyg.2	-	c.2973G>A	c.(2971-2973)CAG>CAA	p.Q991Q	SORBS2_uc003iyh.2_Silent_p.Q601Q|SORBS2_uc011ckw.1_Silent_p.Q438Q|SORBS2_uc003iyi.2_Silent_p.Q508Q|SORBS2_uc011ckx.1_Silent_p.Q443Q|SORBS2_uc003iyk.2_Silent_p.Q421Q|SORBS2_uc003iyl.2_Silent_p.Q877Q|SORBS2_uc003iym.2_Silent_p.Q977Q|SORBS2_uc003iyn.1_Silent_p.Q468Q|SORBS2_uc011cku.1_Silent_p.Q269Q|SORBS2_uc011ckv.1_Silent_p.Q781Q|SORBS2_uc003iyd.2_Silent_p.Q576Q|SORBS2_uc003iye.2_Silent_p.Q450Q|SORBS2_uc003iya.2_Silent_p.Q397Q|SORBS2_uc003iyb.2_Silent_p.Q350Q|SORBS2_uc003iyc.2_Silent_p.Q330Q|SORBS2_uc003iyf.2_Silent_p.Q413Q|SORBS2_uc003iyo.1_Silent_p.Q326Q	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	877	SH3 1.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		Esophageal Squamous(153;41 2433 9491 36028)								0.061224	-2.6181	7.231619	3	46	KEEP	---	---	---	---	capture		Silent	SNP	186539747	186539747	15428	4	C	T	T	T	415	32	SORBS2	2	2
TTC37	9652	broad.mit.edu	37	5	94838675	94838675	+	Missense_Mutation	SNP	C	G	G			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:94838675C>G	uc003klb.2	-	c.3250G>C	c.(3250-3252)GAG>CAG	p.E1084Q		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1084	TPR 18.						binding			ovary(3)|pancreas(1)	4														0.069307	-1.630687	17.698614	7	94	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	94838675	94838675	17260	5	C	G	G	G	390	30	TTC37	3	3
TXNRD1	7296	broad.mit.edu	37	12	104651847	104651848	+	Frame_Shift_Ins	INS	-	A	A			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:104651847_104651848insA	uc010swk.1	+	c.294_295insA	c.(292-297)CTTGATfs	p.L98fs	TXNRD1_uc001tkm.1_Frame_Shift_Ins_p.L101fs	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	98_99	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						Ovarian(139;555 1836 9186 9946 10884)								0.33			3	6		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	104651847	104651848	17363	12	-	A	A	A	808	63	TXNRD1	5	5
PRRT2	112476	broad.mit.edu	37	16	29825015	29825016	+	Frame_Shift_Ins	INS	-	C	C			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:29825015_29825016insC	uc002dud.2	+	c.640_641insC	c.(640-642)GCCfs	p.A214fs	BOLA2_uc010bzb.1_Intron|PRRT2_uc002due.3_Frame_Shift_Ins_p.A214fs|PRRT2_uc002duf.1_Frame_Shift_Ins_p.A214fs|C16orf53_uc002dug.3_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	214	Extracellular (Potential).|Pro-rich.			A -> AP (in Ref. 3; CAD38881).	response to biotic stimulus	integral to membrane					0														0.40			4	6		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	29825015	29825016	13059	16	-	C	C	C	546	42	PRRT2	5	5
TTLL10	254173	broad.mit.edu	37	1	1116222	1116223	+	Frame_Shift_Ins	INS	-	G	G			TCGA-17-Z054-01	TCGA-17-Z054-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:1116222_1116223insG	uc001acy.2	+	c.737_738insG	c.(736-738)CCGfs	p.P246fs	TTLL10_uc010nyg.1_Frame_Shift_Ins_p.P246fs|TTLL10_uc001acz.1_Frame_Shift_Ins_p.P173fs	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	246	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)										0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	1116222	1116223	17278	1	-	G	G	G	299	23	TTLL10	5	5
