Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
CYP2E1	1571	broad.mit.edu	36	10	135201251	135201251	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:135201251G>C	uc001lnj.1	+	c.1162G>C	c.(1162-1164)GTC>CTC	p.V388L	CYP2E1_uc001lnk.1_Missense_Mutation_p.V251L|CYP2E1_uc009ybl.1_Missense_Mutation_p.V189L|CYP2E1_uc009ybm.1_Missense_Mutation_p.V42L|CYP2E1_uc001lnl.1_Missense_Mutation_p.V189L	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	388					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidation-reduction process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)			Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)									0.333333	53.019461	54.293781	17	34	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Missense_Mutation	SNP	135201251	135201251	4335	10	G	C	C	36	36	CYP2E1	C	3	3
ARHGAP32	9743	broad.mit.edu	36	11	128346035	128346035	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:128346035G>C	uc009zcp.1	-	c.4241C>G	c.(4240-4242)CCC>CGC	p.P1414R	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.1_Missense_Mutation_p.P373R|ARHGAP32_uc001qez.1_Missense_Mutation_p.P1065R	NM_014715	NP_055530	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 2	1414	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5														0.119403	7.985058	17.485526	8	59	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	128346035	128346035	893	11	G	C	C	43	43	ARHGAP32	C	3	3
CHRNA10	57053	broad.mit.edu	36	11	3644359	3644359	+	Missense_Mutation	SNP	T	C	C			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:3644359T>C	uc001lyf.1	-	c.907A>G	c.(907-909)ATG>GTG	p.M303V		NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	303	Helical; (Potential).				regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)			Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	Melanoma(153;17 1869 2949 7120 36888)								0.16	17.648825	25.924417	12	63	TT		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Missense_Mutation	SNP	3644359	3644359	3516	11	T	C	C	51	51	CHRNA10	C	4	4
BBS1	582	broad.mit.edu	36	11	66045424	66045424	+	Splice_Site_SNP	SNP	G	T	T			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:66045424G>T	uc001oii.1	+	c.941_splice	c.e9+1	p.R314_splice	ZDHHC24_uc001oim.1_Non-coding_Transcript|ZDHHC24_uc009yrg.1_3'UTR|BBS1_uc001oij.1_Splice_Site_SNP_p.R277_splice|BBS1_uc001oik.1_Splice_Site_SNP_p.R201_splice|BBS1_uc001oil.1_Intron	NM_024649	NP_078925			Bardet-Biedl syndrome 1						photoreceptor cell maintenance|response to stimulus|retina homeostasis|sensory cilium assembly	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						GBM(152;173 2612 9770 10137)								0.209302	7.387303	10.884369	9	34	GG		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	66045424	66045424	1356	11	G	T	T	44	44	BBS1	T	5	3
ODZ4	26011	broad.mit.edu	36	11	78118225	78118225	+	Missense_Mutation	SNP	T	C	C			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:78118225T>C	uc001ozl.2	-	c.3250A>G	c.(3250-3252)ATC>GTC	p.I1084V		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1084	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4														0.362069	65.462535	66.432214	21	37	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	78118225	78118225	11242	11	T	C	C	51	51	ODZ4	C	4	4
KIAA1467	57613	broad.mit.edu	36	12	13100022	13100022	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:13100022G>A	uc001rbi.1	+	c.308G>A	c.(307-309)CGC>CAC	p.R103H	KIAA1467_uc009zhx.1_Non-coding_Transcript	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	103						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)												0.117647	19.774552	44.239025	20	150	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(232;0.157)	Missense_Mutation	SNP	13100022	13100022	8544	12	G	A	A	38	38	KIAA1467	A	1	1
HIST4H4	121504	broad.mit.edu	36	12	14815028	14815028	+	Silent	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:14815028A>G	uc001rcf.2	-	c.258T>C	c.(256-258)GAT>GAC	p.D86D	HIST4H4_uc001rce.1_Non-coding_Transcript	NM_175054	NP_778224	P62805	H4_HUMAN	histone cluster 4, H4	86					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2												OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.120301	17.914141	36.72209	16	117	AA		KEEP	---	---	---	---	capture			Silent	SNP	14815028	14815028	7476	12	A	G	G	8	8	HIST4H4	G	4	4
FREM2	341640	broad.mit.edu	36	13	38323866	38323866	+	Silent	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr13:38323866A>G	uc001uwv.1	+	c.6786A>G	c.(6784-6786)GAA>GAG	p.E2262E	FREM2_uc001uww.2_Silent_p.E348E	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2262	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	10		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)												0.225806	61.22811	67.647025	21	72	AA		KEEP	---	---	---	---	capture		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)	Silent	SNP	38323866	38323866	6292	13	A	G	G	2	2	FREM2	G	4	4
AKAP11	11215	broad.mit.edu	36	13	41775884	41775884	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr13:41775884A>G	uc001uys.1	+	c.5002A>G	c.(5002-5004)AGT>GGT	p.S1668G		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1668					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)												0.136364	9.619057	15.253515	6	38	AA		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)	Missense_Mutation	SNP	41775884	41775884	450	13	A	G	G	7	7	AKAP11	G	4	4
AHNAK2	113146	broad.mit.edu	36	14	104480404	104480404	+	Silent	SNP	G	A	A	rs59373922	unknown	TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:104480404G>A	uc010axc.1	-	c.12429C>T	c.(12427-12429)TTC>TTT	p.F4143F	AHNAK2_uc001ypx.2_Silent_p.F4043F	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4143						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)												0.29	310.348823	326.152805	116	284	GG		KEEP	---	---	---	---	capture	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)		Silent	SNP	104480404	104480404	418	14	G	A	A	37	37	AHNAK2	A	1	1
RNASE4	6038	broad.mit.edu	36	14	20237758	20237758	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr14:20237758C>T	uc001vxy.2	+	c.388C>T	c.(388-390)CGT>TGT	p.R130C	RNASE4_uc001vxx.2_Non-coding_Transcript|RNASE4_uc001vya.1_Missense_Mutation_p.R130C|RNASE4_uc010ahz.1_Missense_Mutation_p.R130C	NM_002937	NP_919412	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	130					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)					Esophageal Squamous(59;1059 1362 26290 51151)								0.206612	54.505998	64.162173	25	96	CC		KEEP	---	---	---	---	capture	Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)	Missense_Mutation	SNP	20237758	20237758	13883	14	C	T	T	19	19	RNASE4	T	1	1
PAK6	56924	broad.mit.edu	36	15	38345702	38345702	+	Missense_Mutation	SNP	G	A	A	rs61732685	unknown	TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr15:38345702G>A	uc010bbl.1	+	c.572G>A	c.(571-573)CGC>CAC	p.R191H	PAK6_uc010bbm.1_Missense_Mutation_p.R191H|PAK6_uc001zky.2_Missense_Mutation_p.R191H|PAK6_uc010bbn.1_Missense_Mutation_p.R191H|PAK6_uc001zlb.2_Missense_Mutation_p.R191H	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	191	Linker.				protein phosphorylation		ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|large_intestine(1)|ovary(1)	5		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)							p.R191H(OCILY19-Tumor)	94				0.411765	41.544011	41.775111	14	20	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)	Missense_Mutation	SNP	38345702	38345702	11820	15	G	A	A	38	38	PAK6	A	1	1
SLC12A3	6559	broad.mit.edu	36	16	55458560	55458560	+	Silent	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:55458560C>T	uc002ekd.2	+	c.360C>T	c.(358-360)GGC>GGT	p.G120G	SLC12A3_uc010ccm.1_Silent_p.G120G|SLC12A3_uc010ccn.1_Silent_p.G119G	NM_000339	NP_000330	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 1	120	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)									0.228571	18.485995	20.84851	8	27	CC		KEEP	---	---	---	---	capture			Silent	SNP	55458560	55458560	14879	16	C	T	T	27	27	SLC12A3	T	1	1
MYH4	4622	broad.mit.edu	36	17	10291231	10291231	+	Missense_Mutation	SNP	T	A	A			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr17:10291231T>A	uc002gmn.1	-	c.4993A>T	c.(4993-4995)ATC>TTC	p.I1665F		NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1665	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|central_nervous_system(1)	11														0.155963	36.415959	48.72265	17	92	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	10291231	10291231	10432	17	T	A	A	51	51	MYH4	A	4	4
MYH1	4619	broad.mit.edu	36	17	10336593	10336593	+	Silent	SNP	G	T	T			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:10336593G>T	uc002gmo.1	-	c.5685C>A	c.(5683-5685)GTC>GTA	p.V1895V		NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1895	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|breast(3)|kidney(1)|skin(1)	15										585				0.36	170.070931	173.092772	63	112	GG		KEEP	---	---	---	---	capture			Silent	SNP	10336593	10336593	10424	17	G	T	T	45	45	MYH1	T	3	3
FAM83G	644815	broad.mit.edu	36	17	18847683	18847683	+	Silent	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:18847683G>A	uc002guw.1	-	c.397C>T	c.(397-399)CTG>TTG	p.L133L	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002guv.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	133										ovary(1)	1														0.222222	13.834749	15.752199	6	21	GG		KEEP	---	---	---	---	capture			Silent	SNP	18847683	18847683	5865	17	G	A	A	35	35	FAM83G	A	2	2
TP53	7157	broad.mit.edu	36	17	7519280	7519280	+	Splice_Site_SNP	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:7519280C>T	uc002gim.2	-	c.376_splice	c.e5-1	p.Y126_splice	TP53_uc002gig.1_Splice_Site_SNP_p.Y126_splice|TP53_uc002gih.1_Splice_Site_SNP_p.Y126_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Splice_Site_SNP_p.Y126_splice|TP53_uc010cni.1_Splice_Site_SNP_p.Y126_splice|TP53_uc002gij.2_Splice_Site_SNP_p.Y126_splice|TP53_uc010cnj.1_Splice_Site_SNP|TP53_uc002gin.2_Splice_Site_SNP_p.Y33_splice|TP53_uc002gio.2_Splice_Site_SNP	NM_001126112	NP_001119584			tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.?(31)|p.0?(6)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)				Pancreas(47;798 1329 9957 10801)		111	(F36P-Tumor)|(BICR56-Tumor)|(OVCAR8-Tumor)|(BECKER-Tumor)|(CORL279-Tumor)|(SNU201-Tumor)	690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.633333	66.634329	67.104251	19	11	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)	Splice_Site_SNP	SNP	7519280	7519280	16923	17	C	T	T	20	20	TP53	T	5	2
SGSH	6448	broad.mit.edu	36	17	75800487	75800487	+	Silent	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:75800487G>A	uc002jxz.2	-	c.927C>T	c.(925-927)AGC>AGT	p.S309S	SGSH_uc002jya.2_Silent_p.S106S|SGSH_uc002jxy.2_3'UTR	NM_000199	NP_000190	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase precursor	309					proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0952)													0.389831	68.413168	69.039947	23	36	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)		Silent	SNP	75800487	75800487	14712	17	G	A	A	38	38	SGSH	A	1	1
SETBP1	26040	broad.mit.edu	36	18	40787088	40787088	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr18:40787088G>C	uc010dni.1	+	c.3623G>C	c.(3622-3624)AGA>ACA	p.R1208T	SETBP1_uc002laz.1_Missense_Mutation_p.R1208T	NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1262						nucleus	DNA binding			large_intestine(1)	1														0.090909	8.664627	27.220811	10	100	GG		KEEP	---	---	---	---	capture		Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)	Missense_Mutation	SNP	40787088	40787088	14617	18	G	C	C	33	33	SETBP1	C	3	3
CYP4F12	66002	broad.mit.edu	36	19	15668863	15668863	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:15668863C>T	uc002nbl.2	+	c.1543C>T	c.(1543-1545)CGG>TGG	p.R515W		NM_023944	NP_076433	Q9HCS2	CP4FC_HUMAN	cytochrome P450, family 4, subfamily F,	515					oxidation-reduction process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|central_nervous_system(2)	4	Acute lymphoblastic leukemia(2;0.0367)													0.209459	62.430586	74.02195	31	117	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	15668863	15668863	4352	19	C	T	T	27	27	CYP4F12	T	1	1
FCGBP	8857	broad.mit.edu	36	19	45059669	45059669	+	Silent	SNP	C	G	G			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:45059669C>G	uc002omp.2	-	c.13131G>C	c.(13129-13131)ACG>ACC	p.T4377T		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4377	TIL 10.					extracellular region	protein binding			ovary(4)|central_nervous_system(1)	5	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)													0.8125	29.13743	30.588544	13	3	CC		KEEP	---	---	---	---	capture	Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)		Silent	SNP	45059669	45059669	6015	19	C	G	G	27	27	FCGBP	G	3	3
USP29	57663	broad.mit.edu	36	19	62333044	62333044	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr19:62333044A>G	uc002qny.1	+	c.1189A>G	c.(1189-1191)ACT>GCT	p.T397A	USP29_uc010etu.1_Missense_Mutation_p.T397A	NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific protease 29	397					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			ovary(2)|breast(2)|pancreas(1)	5		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)												0.161905	41.412865	52.821231	17	88	AA		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)	Missense_Mutation	SNP	62333044	62333044	17623	19	A	G	G	14	14	USP29	G	4	4
TRIP10	9322	broad.mit.edu	36	19	6702206	6702206	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:6702206G>A	uc002mfs.1	+	c.1790G>A	c.(1789-1791)CGA>CAA	p.R597Q	TRIP10_uc010dux.1_Missense_Mutation_p.E551K|TRIP10_uc002mfr.1_Missense_Mutation_p.R541Q|TRIP10_uc010duy.1_Non-coding_Transcript|TRIP10_uc010duz.1_Missense_Mutation_p.R360Q	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	597	Interaction with PDE6G (By similarity).|SH3.|Required for podosome formation.|Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.|Interaction with DNM1 and WASL.|Required for interaction with FASLG and localization to lysosomes.|Interaction with WAS.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1														0.59375	294.313913	295.537386	95	65	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	6702206	6702206	17104	19	G	A	A	37	37	TRIP10	A	1	1
MYBPHL	343263	broad.mit.edu	36	1	109641056	109641056	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:109641056C>T	uc001dxk.1	-	c.602G>A	c.(601-603)CGC>CAC	p.R201H	MYBPHL_uc001dxl.2_Intron	NM_001010985	NP_001010985	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	201	Fibronectin type-III.									ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)												0.164179	21.489939	28.659489	11	56	CC		KEEP	---	---	---	---	capture		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)	Missense_Mutation	SNP	109641056	109641056	10410	1	C	T	T	27	27	MYBPHL	T	1	1
BCAS2	10286	broad.mit.edu	36	1	114925727	114925727	+	Silent	SNP	G	C	C			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:114925727G>C	uc001efa.1	-	c.9C>G	c.(7-9)GGC>GGG	p.G3G	DENND2C_uc001eez.2_Intron	NM_005872	NP_005863	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	3					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			large_intestine(1)	1	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)												0.3	6.419692	6.778033	3	7	GG		KEEP	---	---	---	---	capture		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Silent	SNP	114925727	114925727	1372	1	G	C	C	46	46	BCAS2	C	3	3
SSR2	6746	broad.mit.edu	36	1	154256477	154256477	+	Nonsense_Mutation	SNP	C	A	A			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:154256477C>A	uc001fmx.1	-	c.106G>T	c.(106-108)GAG>TAG	p.E36*	SSR2_uc001fmw.1_Non-coding_Transcript|SSR2_uc001fmy.1_Non-coding_Transcript|SSR2_uc009wrm.1_Nonsense_Mutation_p.E39*|SSR2_uc001fmz.1_Nonsense_Mutation_p.E39*	NM_003145	NP_003136	P43308	SSRB_HUMAN	signal sequence receptor, beta precursor	36	Lumenal (Potential).				cotranslational protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)													0.425287	102.147803	102.573869	37	50	CC		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	154256477	154256477	15707	1	C	A	A	30	30	SSR2	A	5	3
NDUFS2	4720	broad.mit.edu	36	1	159448880	159448880	+	Nonsense_Mutation	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:159448880C>T	uc001fyv.1	+	c.1102C>T	c.(1102-1104)CGA>TGA	p.R368*	NDUFS2_uc001fyw.1_Nonsense_Mutation_p.R368*|NDUFS2_uc001fyx.1_Nonsense_Mutation_p.R342*|FCER1G_uc001fyz.1_5'Flank|FCER1G_uc001fza.1_5'Flank	NM_004550	NP_004541	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2	368					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding				0	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)				NADH(DB00157)									0.2	17.548949	21.317177	9	36	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(70;0.00376)		Nonsense_Mutation	SNP	159448880	159448880	10691	1	C	T	T	27	27	NDUFS2	T	5	1
GJC2	57165	broad.mit.edu	36	1	226413328	226413328	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:226413328G>A	uc001hsk.1	+	c.1246G>A	c.(1246-1248)GGA>AGA	p.G416R	GJC2_uc009xey.1_Missense_Mutation_p.G416R	NM_020435	NP_065168	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	416	Cytoplasmic (Potential).				cell death	connexon complex|integral to membrane					0		Prostate(94;0.0405)												0.444444	14.336165	14.391399	8	10	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	226413328	226413328	6683	1	G	A	A	35	35	GJC2	A	2	2
DNAJB4	11080	broad.mit.edu	36	1	78243420	78243420	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr1:78243420A>G	uc001dij.1	+	c.38A>G	c.(37-39)AAA>AGA	p.K13R		NM_007034	NP_008965	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	13	J.				protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding				0														0.191589	108.752288	127.764917	41	173	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	78243420	78243420	4805	1	A	G	G	1	1	DNAJB4	G	4	4
ODF2L	57489	broad.mit.edu	36	1	86594811	86594811	+	Silent	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:86594811C>T	uc001dln.1	-	c.1335G>A	c.(1333-1335)GCG>GCA	p.A445A	ODF2L_uc001dll.1_Silent_p.A474A|ODF2L_uc001dlm.1_Silent_p.A445A|ODF2L_uc001dlo.1_Silent_p.A314A|ODF2L_uc001dlp.1_Intron	NM_020729	NP_001007023	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	474	Potential.									ovary(1)	1														0.39726	85.458046	86.132554	29	44	CC		KEEP	---	---	---	---	capture		all cancers(265;0.0313)|Epithelial(280;0.0611)	Silent	SNP	86594811	86594811	11233	1	C	T	T	23	23	ODF2L	T	1	1
MYH7B	57644	broad.mit.edu	36	20	33036579	33036579	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:33036579C>T	uc002xbi.1	+	c.917C>T	c.(916-918)GCG>GTG	p.A306V		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	264	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2														0.168224	34.389518	45.540973	18	89	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(18;0.00691)		Missense_Mutation	SNP	33036579	33036579	10435	20	C	T	T	27	27	MYH7B	T	1	1
PTPRT	11122	broad.mit.edu	36	20	40344558	40344558	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:40344558G>A	uc010ggj.1	-	c.2161C>T	c.(2161-2163)CGT>TGT	p.R721C	PTPRT_uc002xkg.1_Missense_Mutation_p.R721C	NM_133170	NP_573400	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	721	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			ovary(7)|lung(5)|skin(2)	14		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)								646				0.215054	47.548978	54.519153	20	73	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	40344558	40344558	13270	20	G	A	A	37	37	PTPRT	A	1	1
KCNE1	3753	broad.mit.edu	36	21	34743616	34743616	+	Missense_Mutation	SNP	G	T	T			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr21:34743616G>T	uc010gmp.1	-	c.187C>A	c.(187-189)CTG>ATG	p.L63M	KCNE1_uc002ytz.1_Missense_Mutation_p.L63M|KCNE1_uc010gmq.1_Missense_Mutation_p.L63M|KCNE1_uc010gmr.1_Missense_Mutation_p.L63M|KCNE1_uc002yua.1_Non-coding_Transcript|KCNE1_uc010gms.1_Missense_Mutation_p.L63M	NM_001127670	NP_001121142	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related	63	Helical; (Potential).				blood circulation|membrane depolarization|muscle contraction|regulation of heart contraction|sensory perception of sound	lysosome|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(2)	2					Indapamide(DB00808)									0.225352	36.773171	41.685954	16	55	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	34743616	34743616	8326	21	G	T	T	34	34	KCNE1	T	3	3
KRTAP10-2	386679	broad.mit.edu	36	21	44795611	44795611	+	Silent	SNP	C	G	G			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr21:44795611C>G	uc002zfi.1	-	c.159G>C	c.(157-159)GTG>GTC	p.V53V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	53	22 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)	1														0.475	123.037786	123.081685	38	42	CC		KEEP	---	---	---	---	capture			Silent	SNP	44795611	44795611	8824	21	C	G	G	17	17	KRTAP10-2	G	3	3
PPM1F	9647	broad.mit.edu	36	22	20615657	20615657	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:20615657G>C	uc002zvp.1	-	c.754C>G	c.(754-756)CAG>GAG	p.Q252E	PPM1F_uc002zvq.2_Missense_Mutation_p.Q252E	NM_014634	NP_055449	P49593	PPM1F_HUMAN	protein phosphatase 1F	252					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(2)|large_intestine(1)|breast(1)|kidney(1)	5	Colorectal(54;0.105)													0.333333	6.412475	6.924302	6	12	GG		KEEP	---	---	---	---	capture		READ - Rectum adenocarcinoma(21;0.155)	Missense_Mutation	SNP	20615657	20615657	12774	22	G	C	C	46	46	PPM1F	C	3	3
MCHR1	2847	broad.mit.edu	36	22	39407772	39407772	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:39407772G>A	uc003ayz.1	+	c.1163G>A	c.(1162-1164)CGC>CAC	p.R388H	MCHR1_uc003aza.1_Missense_Mutation_p.R277H	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	388	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0														0.143791	34.046493	52.744375	22	131	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	39407772	39407772	9771	22	G	A	A	38	38	MCHR1	A	1	1
SEPT10	151011	broad.mit.edu	36	2	109707957	109707957	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:109707957G>C	uc002tey.1	-	c.59C>G	c.(58-60)ACA>AGA	p.T20R	SEPT10_uc002tew.1_Missense_Mutation_p.T20R|SEPT10_uc002tex.1_Intron	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	20					cell cycle|cell division	septin complex	GTP binding				0														0.095238	18.065166	45.6912	16	152	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	109707957	109707957	14546	2	G	C	C	48	48	SEPT10	C	3	3
NEB	4703	broad.mit.edu	36	2	152226944	152226944	+	Missense_Mutation	SNP	T	C	C			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:152226944T>C	uc010fnx.1	-	c.5921A>G	c.(5920-5922)GAC>GGC	p.D1974G		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin	1974	Nebulin 52.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(1)|skin(1)|pancreas(1)	19														0.322034	120.708413	124.027485	38	80	TT		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(221;0.219)	Missense_Mutation	SNP	152226944	152226944	10701	2	T	C	C	58	58	NEB	C	4	4
LASS6	253782	broad.mit.edu	36	2	169112396	169112396	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr2:169112396A>G	uc002uec.1	+	c.215A>G	c.(214-216)AAT>AGT	p.N72S	LASS6_uc002ueb.1_Missense_Mutation_p.N72S	NM_203463	NP_982288	Q6ZMG9	LASS6_HUMAN	longevity assurance homolog 6	72	Cytoplasmic (Potential).|Homeobox.				regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0														0.101695	8.205609	17.539162	6	53	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	169112396	169112396	8966	2	A	G	G	4	4	LASS6	G	4	4
IDH1	3417	broad.mit.edu	36	2	208821357	208821357	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:208821357C>T	uc002vcs.1	-	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.1_Missense_Mutation_p.R132H|IDH1_uc002vcu.1_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(1725)|p.R132?(210)|p.R132C(92)|p.R132L(48)|p.R132G(26)|p.R132S(11)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(1848)|haematopoietic_and_lymphoid_tissue(593)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2451						Pancreas(158;264 1958 3300 35450 36047)				134				0.347107	117.413983	119.910588	42	79	CC		KEEP	---	---	---	---	capture		Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)	Missense_Mutation	SNP	208821357	208821357	7794	2	C	T	T	19	19	IDH1	T	1	1
ZNF142	7701	broad.mit.edu	36	2	219229349	219229349	+	Silent	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:219229349C>T	uc002vin.1	-	c.48G>A	c.(46-48)GAG>GAA	p.E16E	ZNF142_uc002vil.1_5'UTR|ZNF142_uc002vim.1_5'UTR|ZNF142_uc010fvt.1_5'UTR|BCS1L_uc002vio.1_5'Flank	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142 isoform 1	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3		Renal(207;0.0474)				Colon(170;867 1942 8995 15834 18053)								0.457831	118.840966	118.969495	38	45	CC		KEEP	---	---	---	---	capture		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Silent	SNP	219229349	219229349	18322	2	C	T	T	32	32	ZNF142	T	2	2
TMEM214	54867	broad.mit.edu	36	2	27111523	27111523	+	Missense_Mutation	SNP	T	A	A			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:27111523T>A	uc002ria.2	+	c.368T>A	c.(367-369)CTG>CAG	p.L123Q	TMEM214_uc002rib.2_Missense_Mutation_p.L123Q|TMEM214_uc010eyp.1_Non-coding_Transcript	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	123						integral to membrane	protein binding				0														0.5	114.774514	114.774514	37	37	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	27111523	27111523	16673	2	T	A	A	55	55	TMEM214	A	4	4
FAM176A	84141	broad.mit.edu	36	2	75598708	75598708	+	Missense_Mutation	SNP	C	A	A			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:75598708C>A	uc002sni.1	-	c.67G>T	c.(67-69)GCC>TCC	p.A23S	FAM176A_uc002snj.1_Missense_Mutation_p.A10S|FAM176A_uc002snk.1_Missense_Mutation_p.A23S	NM_032181	NP_115557	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	23	Necessary for the localization and biological activity.				apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0														0.311828	83.141597	86.073273	29	64	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	75598708	75598708	5705	2	C	A	A	26	26	FAM176A	A	3	3
KIDINS220	57498	broad.mit.edu	36	2	8789457	8789457	+	Missense_Mutation	SNP	T	C	C			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:8789457T>C	uc002qzc.1	-	c.4160A>G	c.(4159-4161)TAT>TGT	p.Y1387C	KIDINS220_uc002qzb.1_Missense_Mutation_p.Y241C|KIDINS220_uc002qzd.1_Missense_Mutation_p.Y1288C	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1387	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)													0.364912	350.854801	355.416703	104	181	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	8789457	8789457	8582	2	T	C	C	49	49	KIDINS220	C	4	4
C3orf17	25871	broad.mit.edu	36	3	114207240	114207240	+	Missense_Mutation	SNP	T	C	C			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr3:114207240T>C	uc003dzr.1	-	c.1537A>G	c.(1537-1539)ATG>GTG	p.M513V	C3orf17_uc003dzq.1_Missense_Mutation_p.M138V|C3orf17_uc003dzt.1_Missense_Mutation_p.M416V|C3orf17_uc003dzs.1_Missense_Mutation_p.M377V|C3orf17_uc010hqg.1_Missense_Mutation_p.M338V|C3orf17_uc003dzu.1_Missense_Mutation_p.M442V|C3orf17_uc010hqh.1_Missense_Mutation_p.M138V	NM_015412	NP_001020243	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871 isoform a	513						integral to membrane					0														0.391509	285.488444	287.670686	83	129	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	114207240	114207240	2303	3	T	C	C	52	52	C3orf17	C	4	4
CCDC37	348807	broad.mit.edu	36	3	127621239	127621239	+	Silent	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:127621239G>A	uc010hsg.1	+	c.804G>A	c.(802-804)TCG>TCA	p.S268S	CCDC37_uc003eiu.1_Silent_p.S267S	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	267										ovary(1)	1														0.133333	30.369366	53.887392	24	156	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(114;0.166)	Silent	SNP	127621239	127621239	2931	3	G	A	A	38	38	CCDC37	A	1	1
NUP210	23225	broad.mit.edu	36	3	13407743	13407743	+	Silent	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:13407743C>T	uc003bxv.1	-	c.501G>A	c.(499-501)GCG>GCA	p.A167A		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210	167	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(2)|pancreas(1)|liver(1)	10	all_neural(104;0.187)									587				0.3	25.164049	26.235744	9	21	CC		KEEP	---	---	---	---	capture			Silent	SNP	13407743	13407743	11165	3	C	T	T	23	23	NUP210	T	1	1
FBLN2	2199	broad.mit.edu	36	3	13587330	13587330	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:13587330G>C	uc003bya.1	+	c.475G>C	c.(475-477)GCC>CCC	p.A159P	FBLN2_uc003byb.1_Missense_Mutation_p.A159P	NM_001004019	NP_001004019	P98095	FBLN2_HUMAN	fibulin 2 isoform a precursor	159	Subdomain NA (Cys-rich).|N.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1														0.266667	6.362773	7.129394	4	11	GG		KEEP	---	---	---	---	capture	UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)		Missense_Mutation	SNP	13587330	13587330	5935	3	G	C	C	42	42	FBLN2	C	3	3
VEPH1	79674	broad.mit.edu	36	3	158695784	158695784	+	Missense_Mutation	SNP	C	A	A			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:158695784C>A	uc003fbj.1	-	c.49G>T	c.(49-51)GCT>TCT	p.A17S	VEPH1_uc003fbk.1_Missense_Mutation_p.A17S|VEPH1_uc010hvu.1_Missense_Mutation_p.A17S|VEPH1_uc003fbm.2_Missense_Mutation_p.A17S|VEPH1_uc003fbn.2_Missense_Mutation_p.A17S	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	17						plasma membrane				breast(3)|ovary(1)|lung(1)	5														0.122449	29.657837	57.016833	24	172	CC		KEEP	---	---	---	---	capture	Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)		Missense_Mutation	SNP	158695784	158695784	17721	3	C	A	A	28	28	VEPH1	A	3	3
NICN1	84276	broad.mit.edu	36	3	49438792	49438792	+	Missense_Mutation	SNP	T	G	G			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr3:49438792T>G	uc003cwz.1	-	c.206A>C	c.(205-207)CAC>CCC	p.H69P	NICN1_uc003cxa.2_Non-coding_Transcript	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	69						microtubule|nucleus					0														0.220588	38.90054	43.779753	15	53	TT		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Missense_Mutation	SNP	49438792	49438792	10814	3	T	G	G	59	59	NICN1	G	4	4
PCDH18	54510	broad.mit.edu	36	4	138662254	138662254	+	Missense_Mutation	SNP	G	T	T			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:138662254G>T	uc003ihe.2	-	c.2787C>A	c.(2785-2787)GAC>GAA	p.D929E	PCDH18_uc003ihf.2_Missense_Mutation_p.D921E|PCDH18_uc003ihg.2_Missense_Mutation_p.D708E	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	929	Interaction with DAB1 (By similarity).|Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)	3	all_hematologic(180;0.24)													0.183168	77.170671	96.340774	37	165	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	138662254	138662254	11933	4	G	T	T	44	44	PCDH18	T	3	3
SPOCK3	50859	broad.mit.edu	36	4	168158155	168158155	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:168158155C>T	uc003iri.1	-	c.279G>A	c.(277-279)ATG>ATA	p.M93I	SPOCK3_uc003irj.1_Missense_Mutation_p.M90I|SPOCK3_uc003irk.2_Missense_Mutation_p.M90I	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	93					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)												0.117647	11.491119	28.808698	14	105	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(119;0.02)	Missense_Mutation	SNP	168158155	168158155	15594	4	C	T	T	29	29	SPOCK3	T	2	2
MFAP3L	9848	broad.mit.edu	36	4	171163527	171163527	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:171163527G>A	uc003isp.2	-	c.77C>T	c.(76-78)GCC>GTC	p.A26V	MFAP3L_uc003isn.2_5'Flank	NM_021647	NP_001009554	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like isoform	26						integral to membrane|plasma membrane				ovary(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)												0.56962	142.099927	142.439023	45	34	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)	Missense_Mutation	SNP	171163527	171163527	9906	4	G	A	A	42	42	MFAP3L	A	2	2
LGI2	55203	broad.mit.edu	36	4	24628821	24628821	+	Missense_Mutation	SNP	C	A	A			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:24628821C>A	uc003grf.1	-	c.543G>T	c.(541-543)TGG>TGT	p.W181C		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	181	LRRCT.					extracellular region					0		Breast(46;0.173)												0.574661	392.538278	393.611111	127	94	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	24628821	24628821	9078	4	C	A	A	18	18	LGI2	A	3	3
FAT2	2196	broad.mit.edu	36	5	150914366	150914366	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:150914366A>G	uc003lue.2	-	c.3695T>C	c.(3694-3696)ATC>ACC	p.I1232T		NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1232	Extracellular (Potential).|Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)	4		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)												0.375	282.97364	286.153902	87	145	AA		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Missense_Mutation	SNP	150914366	150914366	5926	5	A	G	G	12	12	FAT2	G	4	4
KIAA0319	9856	broad.mit.edu	36	6	24671587	24671587	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr6:24671587A>G	uc003neh.1	-	c.2570T>C	c.(2569-2571)ATT>ACT	p.I857T	KIAA0319_uc010jpt.1_Missense_Mutation_p.I268T	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319	857	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)	1														0.142857	21.568174	31.049527	11	66	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	24671587	24671587	8475	6	A	G	G	4	4	KIAA0319	G	4	4
TULP1	7287	broad.mit.edu	36	6	35585585	35585585	+	Missense_Mutation	SNP	T	C	C			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr6:35585585T>C	uc003okv.2	-	c.598A>G	c.(598-600)AAA>GAA	p.K200E	TULP1_uc003okw.2_Missense_Mutation_p.K147E	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	200					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						GBM(55;1027 1091 11115 23439)								0.130872	67.756077	107.420064	39	259	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	35585585	35585585	17328	6	T	C	C	62	62	TULP1	C	4	4
SPACA1	81833	broad.mit.edu	36	6	88825935	88825935	+	Missense_Mutation	SNP	A	C	C			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr6:88825935A>C	uc003pmn.1	+	c.520A>C	c.(520-522)AAG>CAG	p.K174Q		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	174	Extracellular (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)												0.596491	123.862671	124.327114	34	23	AA		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(108;0.11)	Missense_Mutation	SNP	88825935	88825935	15473	6	A	C	C	5	5	SPACA1	C	4	4
GPER	2852	broad.mit.edu	36	7	1098542	1098542	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:1098542G>C	uc010ksd.1	+	c.652G>C	c.(652-654)GAG>CAG	p.E218Q	C7orf50_uc003sjt.1_Intron|C7orf50_uc003sju.1_Intron|GPER_uc003sjz.1_Missense_Mutation_p.E218Q|GPER_uc003ska.1_Missense_Mutation_p.E218Q|GPER_uc003skb.2_Missense_Mutation_p.E218Q|GPER_uc010kse.1_Missense_Mutation_p.E218Q	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	218	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)												0.210526	10.390511	11.862418	4	15	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)	Missense_Mutation	SNP	1098542	1098542	6881	7	G	C	C	37	37	GPER	C	3	3
CFTR	1080	broad.mit.edu	36	7	116967599	116967599	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:116967599C>G	uc003vjd.1	+	c.1079C>G	c.(1078-1080)ACA>AGA	p.T360R		NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	360	Cytoplasmic (Potential).|ABC transmembrane type-1 1.		QT -> KK (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00148)|all_lung(10;0.00171)				Bumetanide(DB00887)|Glibenclamide(DB01016)									0.187135	80.693255	96.373753	32	139	CC		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(10;0.000534)		Missense_Mutation	SNP	116967599	116967599	3427	7	C	G	G	17	17	CFTR	G	3	3
MGAM	8972	broad.mit.edu	36	7	141411621	141411621	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:141411621C>T	uc003vwy.1	+	c.4502C>T	c.(4501-4503)ACG>ATG	p.T1501M		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1501	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)									0.2	8.288127	9.962921	4	16	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	141411621	141411621	9931	7	C	T	T	19	19	MGAM	T	1	1
NCALD	83988	broad.mit.edu	36	8	102774232	102774232	+	Silent	SNP	T	C	C			TCGA-19-2629-01	TCGA-19-2629-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr8:102774232T>C	uc003yke.1	-	c.447A>G	c.(445-447)ACA>ACG	p.T149T	NCALD_uc003ykf.1_Silent_p.T149T|NCALD_uc003ykg.1_Silent_p.T149T|NCALD_uc003ykh.1_Silent_p.T149T|NCALD_uc003yki.1_Silent_p.T149T|NCALD_uc003ykj.1_Silent_p.T149T|NCALD_uc003ykk.1_Silent_p.T149T|NCALD_uc003ykl.1_Silent_p.T149T	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	149	EF-hand 4.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)													0.330579	117.845226	120.930258	40	81	TT		KEEP	---	---	---	---	capture	all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)		Silent	SNP	102774232	102774232	10600	8	T	C	C	55	55	NCALD	C	4	4
PKHD1L1	93035	broad.mit.edu	36	8	110529653	110529653	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr8:110529653A>G	uc003yne.1	+	c.5882A>G	c.(5881-5883)AAT>AGT	p.N1961S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L	1961	Extracellular (Potential).|IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14														0.317073	40.162263	41.381087	13	28	AA		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)		Missense_Mutation	SNP	110529653	110529653	12397	8	A	G	G	4	4	PKHD1L1	G	4	4
FER1L6	654463	broad.mit.edu	36	8	125116747	125116747	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:125116747G>A	uc003yqw.1	+	c.2335G>A	c.(2335-2337)GTG>ATG	p.V779M		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	779	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|skin(1)	7	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)													0.159292	30.292501	42.779085	18	95	GG		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(47;0.00186)		Missense_Mutation	SNP	125116747	125116747	6052	8	G	A	A	40	40	FER1L6	A	1	1
POLR3D	661	broad.mit.edu	36	8	22161965	22161965	+	Silent	SNP	C	T	T			TCGA-19-2629-01	TCGA-19-2629-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:22161965C>T	uc003xbl.1	+	c.513C>T	c.(511-513)AAC>AAT	p.N171N	POLR3D_uc003xbm.1_Silent_p.N171N	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	171					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0														0.184615	69.774803	87.902426	36	159	CC		KEEP	---	---	---	---	capture		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)	Silent	SNP	22161965	22161965	12659	8	C	T	T	19	19	POLR3D	T	1	1
KCTD9	54793	broad.mit.edu	36	8	25343311	25343311	+	Silent	SNP	G	A	A			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:25343311G>A	uc003xeo.1	-	c.1149C>T	c.(1147-1149)CAC>CAT	p.H383H	PPP2R2A_uc003xek.1_Intron	NM_017634	NP_060104	Q7L273	KCTD9_HUMAN	potassium channel tetramerisation domain	383						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)												0.146341	55.824478	85.412171	36	210	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)	Silent	SNP	25343311	25343311	8422	8	G	A	A	48	48	KCTD9	A	2	2
NCOA2	10499	broad.mit.edu	36	8	71231831	71231831	+	Silent	SNP	A	G	G			TCGA-19-2629-01	TCGA-19-2629-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr8:71231831A>G	uc003xyn.1	-	c.1323T>C	c.(1321-1323)TTT>TTC	p.F441F		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	441					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	soft_tissue(4)|lung(2)|skin(2)|ovary(1)|pancreas(1)	10	Breast(64;0.201)									476				0.138614	25.282379	38.031031	14	87	AA		KEEP	---	---	---	---	capture	Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)		Silent	SNP	71231831	71231831	10628	8	A	G	G	5	5	NCOA2	G	4	4
FXN	2395	broad.mit.edu	36	9	70877415	70877415	+	Nonsense_Mutation	SNP	G	T	T			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:70877415G>T	uc004aha.1	+	c.550G>T	c.(550-552)GAG>TAG	p.E184*	FXN_uc004agz.1_Missense_Mutation_p.M186I	NM_000144	NP_000135	Q16595	FRDA_HUMAN	frataxin isoform 1 preproprotein	184					cellular iron ion homeostasis|cellular response to hydrogen peroxide|heme biosynthetic process|ion transport|iron incorporation into metallo-sulfur cluster|negative regulation of apoptosis|negative regulation of release of cytochrome c from mitochondria|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity|protein autoprocessing|regulation of ferrochelatase activity|response to iron ion	cytosol|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferric iron binding|ferrous iron binding|ferroxidase activity|iron chaperone activity|protein binding				0														0.15625	41.863864	59.922986	25	135	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	70877415	70877415	6365	9	G	T	T	45	45	FXN	T	5	3
TDRD7	23424	broad.mit.edu	36	9	99275635	99275635	+	Missense_Mutation	SNP	G	T	T			TCGA-19-2629-01	TCGA-19-2629-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:99275635G>T	uc004axj.1	+	c.1985G>T	c.(1984-1986)TGC>TTC	p.C662F	TDRD7_uc010msp.1_5'UTR	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	662					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)												0.359431	292.982378	297.877356	101	180	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	99275635	99275635	16262	9	G	T	T	46	46	TDRD7	T	3	3
JMJD1C	221037	broad.mit.edu	36	10	64630286	64630288	+	In_Frame_Del	DEL	TTC	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:64630286_64630288delTTC	uc001jmn.1	-	c.5230_5232delGAA	c.(5230-5232)GAAdel	p.E1744del	JMJD1C_uc001jml.1_In_Frame_Del_p.E1525del|JMJD1C_uc001jmm.1_In_Frame_Del_p.E1456del|JMJD1C_uc009xpi.1_In_Frame_Del_p.E1562del|JMJD1C_uc009xpj.1_Intron|JMJD1C_uc009xpk.1_Intron	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1744					blood coagulation|oxidation-reduction process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)	5	Prostate(12;0.0119)|all_hematologic(501;0.191)													0.38			20	33				---	---	---	---	capture_indel			In_Frame_Del	DEL	64630286	64630288	8254	10	TTC	-	-	60	60	JMJD1C	-	5	5
PSMC3	5702	broad.mit.edu	36	11	47402748	47402749	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:47402748_47402749delTT	uc001nfh.2	-	c.375_376delAA	c.(373-378)AAAACCfs	p.K125fs	PSMC3_uc009ylr.1_Frame_Shift_Del_p.K83fs	NM_002804	NP_002795	P17980	PRS6A_HUMAN	proteasome 26S ATPase subunit 3	125_126					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			ovary(4)	4				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)										0.35			61	111				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	47402748	47402749	13140	11	TT	-	-	60	60	PSMC3	-	5	5
ARID2	196528	broad.mit.edu	36	12	44532189	44532190	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:44532189_44532190delAG	uc001ros.1	+	c.4016_4017delAG	c.(4015-4017)CAGfs	p.Q1339fs	ARID2_uc001ror.2_Frame_Shift_Del_p.Q1339fs|ARID2_uc009zkg.1_Frame_Shift_Del_p.Q795fs|ARID2_uc009zkh.1_Frame_Shift_Del_p.Q966fs|ARID2_uc001rou.1_Frame_Shift_Del_p.Q673fs	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1339					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(1)	7	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)										0.39			32	50				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	44532189	44532190	930	12	AG	-	-	7	7	ARID2	-	5	5
SCAPER	49855	broad.mit.edu	36	15	74846389	74846391	+	In_Frame_Del	DEL	TTC	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:74846389_74846391delTTC	uc002bby.1	-	c.1339_1341delGAA	c.(1339-1341)GAAdel	p.E447del	SCAPER_uc002bbx.1_In_Frame_Del_p.E202del|SCAPER_uc002bbz.1_In_Frame_Del_p.E319del|SCAPER_uc002bca.1_In_Frame_Del_p.E313del|SCAPER_uc002bcb.1_In_Frame_Del_p.E454del|SCAPER_uc002bcc.1_In_Frame_Del_p.E448del	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S phase cyclin A-associated protein in the ER	447	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3														0.32			8	17				---	---	---	---	capture_indel			In_Frame_Del	DEL	74846389	74846391	14359	15	TTC	-	-	60	60	SCAPER	-	5	5
MYO5B	4645	broad.mit.edu	36	18	45733671	45733672	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:45733671_45733672delTC	uc002leb.1	-	c.1708_1709delGA	c.(1708-1710)GACfs	p.D570fs	MYO5B_uc002lec.1_Frame_Shift_Del_p.D569fs	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	570	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(1)	1				READ - Rectum adenocarcinoma(32;0.103)										0.37			49	85				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	45733671	45733672	10474	18	TC	-	-	58	58	MYO5B	-	5	5
NOS1AP	9722	broad.mit.edu	36	1	160523835	160523837	+	In_Frame_Del	DEL	GAA	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:160523835_160523837delGAA	uc001gbv.2	+	c.255_257delGAA	c.(253-258)CTGAAG>CTG	p.K90del	NOS1AP_uc001gbw.2_In_Frame_Del_p.K92del	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	90	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)	2	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)											0.33			51	102				---	---	---	---	capture_indel			In_Frame_Del	DEL	160523835	160523837	10945	1	GAA	-	-	45	45	NOS1AP	-	5	5
TMED5	50999	broad.mit.edu	36	1	93392841	93392844	+	Frame_Shift_Del	DEL	CAAA	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:93392841_93392844delCAAA	uc001dpn.1	-	c.661_664delTTTG	c.(661-666)TTTGAAfs	p.F221fs	TMED5_uc001dpo.1_3'UTR|TMED5_uc001dpp.1_Non-coding_Transcript	NM_016040	NP_057124	Q9Y3A6	TMED5_HUMAN	transmembrane emp24 protein transport domain	221_222	Cytoplasmic (Potential).				transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane				ovary(1)	1		all_lung(203;0.0223)|Lung NSC(277;0.071)|Melanoma(281;0.147)|Glioma(108;0.188)		all cancers(265;0.00108)|GBM - Glioblastoma multiforme(16;0.00407)|Epithelial(280;0.0797)										0.38			49	81				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	93392841	93392844	16537	1	CAAA	-	-	29	29	TMED5	-	5	5
TMPRSS6	164656	broad.mit.edu	36	22	35822071	35822071	+	Frame_Shift_Del	DEL	C	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:35822071_35822071delC	uc003aqt.1	-	c.410_410delG	c.(409-411)GGAfs	p.G137fs	TMPRSS6_uc003aqs.1_Frame_Shift_Del_p.G146fs|TMPRSS6_uc003aqu.2_Frame_Shift_Del_p.G137fs	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	146	Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)	5														0.48			33	36				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	35822071	35822071	16792	22	C	-	-	30	30	TMPRSS6	-	5	5
PIK3R1	5295	broad.mit.edu	36	5	67625375	67625377	+	In_Frame_Del	DEL	GAG	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:67625375_67625377delGAG	uc003jva.1	+	c.1382_1384delGAG	c.(1381-1386)CGAGAA>CAA	p.461_462RE>Q	PIK3R1_uc003jvb.1_In_Frame_Del_p.461_462RE>Q|PIK3R1_uc003jvc.1_In_Frame_Del_p.161_162RE>Q|PIK3R1_uc003jvd.1_In_Frame_Del_p.191_192RE>Q|PIK3R1_uc003jve.1_In_Frame_Del_p.140_141RE>Q	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	461_462					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)|p.F456_R461>S(1)|p.Q457_R461del(1)|p.F456_R461del(1)|p.R461*(1)|p.T454_D464del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(5)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	99		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)					370	TCGA GBM(4;<1E-8)			0.34			30	57				---	---	---	---	capture_indel			In_Frame_Del	DEL	67625375	67625377	12342	5	GAG	-	-	37	37	PIK3R1	-	5	5
HOMER1	9456	broad.mit.edu	36	5	78788535	78788537	+	In_Frame_Del	DEL	TTC	-	-			TCGA-19-2629-01	TCGA-19-2629-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:78788535_78788537delTTC	uc003kfy.1	-	c.66_68delGAA	c.(64-69)AAGAAC>AAC	p.K22del	HOMER1_uc010jab.1_In_Frame_Del_p.K22del|HOMER1_uc010jac.1_In_Frame_Del_p.K22del|HOMER1_uc010jad.1_Intron	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	22	WH1.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)										0.40			117	179				---	---	---	---	capture_indel			In_Frame_Del	DEL	78788535	78788537	7570	5	TTC	-	-	60	60	HOMER1	-	5	5
