Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
CAMK1D	57118	broad.mit.edu	36	10	12842960	12842960	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:12842960G>A	uc001ilo.1	+	c.307G>A	c.(307-309)GGT>AGT	p.G103S	CAMK1D_uc001iln.1_Missense_Mutation_p.G103S	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	103	Protein kinase.				protein phosphorylation	calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1										482				0.90625	102.108774	107.399927	29	3	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(1;3.16e-05)	Missense_Mutation	SNP	12842960	12842960	2714	10	G	A	A	39	39	CAMK1D	A	1	1
MPZL2	10205	broad.mit.edu	36	11	117638487	117638487	+	Silent	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:117638487G>A	uc001psn.1	-	c.312C>T	c.(310-312)TAC>TAT	p.Y104Y	MPZL2_uc001pso.1_Silent_p.Y104Y|MPZL2_uc001psp.1_Silent_p.Y104Y	NM_005797	NP_658911	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	104	Extracellular (Potential).|Ig-like V-type.				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane					0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)												0.4	46.691424	47.041393	16	24	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)	Silent	SNP	117638487	117638487	10142	11	G	A	A	40	40	MPZL2	A	1	1
FLI1	2313	broad.mit.edu	36	11	128185741	128185741	+	Missense_Mutation	SNP	G	T	T			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:128185741G>T	uc001qem.1	+	c.1007G>T	c.(1006-1008)AGC>ATC	p.S336I	FLI1_uc009zci.1_Missense_Mutation_p.S270I	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	336	ETS.				hemostasis|organ morphogenesis|regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2262)	bone(2208)|soft_tissue(46)|autonomic_ganglia(4)|central_nervous_system(4)|ovary(2)|pancreas(2)|lung(1)	2267	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)								400				0.62963	51.77849	52.176435	17	10	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)	Missense_Mutation	SNP	128185741	128185741	6162	11	G	T	T	34	34	FLI1	T	3	3
OR52M1	119772	broad.mit.edu	36	11	4523372	4523372	+	Missense_Mutation	SNP	G	A	A	rs61751910	unknown	TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:4523372G>A	uc001lzb.1	+	c.376G>A	c.(376-378)GTG>ATG	p.V126M		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)												0.818182	89.042847	92.181043	27	6	GG		KEEP	---	---	---	---	capture		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)	Missense_Mutation	SNP	4523372	4523372	11536	11	G	A	A	40	40	OR52M1	A	1	1
GLYAT	10249	broad.mit.edu	36	11	58234736	58234736	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:58234736G>A	uc001nnb.1	-	c.391C>T	c.(391-393)CGC>TGC	p.R131C	GLYAT_uc001nnc.1_Missense_Mutation_p.R131C	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	131					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)				p.R131C(SNU1105-Tumor)|p.R131C(REH-Tumor)	191				0.931034	177.113773	184.316566	54	4	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	58234736	58234736	6747	11	G	A	A	40	40	GLYAT	A	1	1
GPR83	10888	broad.mit.edu	36	11	93753313	93753313	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:93753313G>A	uc001pet.1	-	c.922C>T	c.(922-924)CTC>TTC	p.L308F		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	308	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)												0.84	75.191609	77.943223	21	4	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	93753313	93753313	6988	11	G	A	A	35	35	GPR83	A	2	2
MTMR2	8898	broad.mit.edu	36	11	95234916	95234916	+	Splice_Site_SNP	SNP	T	C	C			TCGA-19-5960-01	TCGA-19-5960-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:95234916T>C	uc001pfu.2	-	c.358_splice	c.e5-1	p.D120_splice	MTMR2_uc001pfs.2_Splice_Site_SNP_p.D48_splice|MTMR2_uc009ywo.1_Splice_Site_SNP_p.D48_splice|MTMR2_uc001pft.2_Splice_Site_SNP_p.D48_splice|MTMR2_uc001pfv.2_Splice_Site_SNP_p.D48_splice	NM_016156	NP_958438			myotubularin-related protein 2 isoform 1							nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)												0.146341	8.32249	13.253446	6	35	TT		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	95234916	95234916	10337	11	T	C	C	53	53	MTMR2	C	5	4
RASSF9	9182	broad.mit.edu	36	12	84723783	84723783	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:84723783G>A	uc001taf.1	-	c.136C>T	c.(136-138)CGC>TGC	p.R46C		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	46	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1														0.434783	88.236276	88.492672	30	39	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	84723783	84723783	13554	12	G	A	A	40	40	RASSF9	A	1	1
DCLK1	9201	broad.mit.edu	36	13	35598120	35598120	+	Missense_Mutation	SNP	G	T	T			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr13:35598120G>T	uc001uvf.1	-	c.155C>A	c.(154-156)TCC>TAC	p.S52Y		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin and CaM kinase-like 1	52					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|protein phosphorylation|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(4)|ovary(2)	6		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)								453				0.482143	77.313795	77.329669	27	29	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)	Missense_Mutation	SNP	35598120	35598120	4462	13	G	T	T	41	41	DCLK1	T	3	3
SLITRK5	26050	broad.mit.edu	36	13	87127408	87127408	+	Silent	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr13:87127408C>T	uc001vln.1	+	c.1764C>T	c.(1762-1764)GAC>GAT	p.D588D	SLITRK5_uc010afg.1_Silent_p.D588D	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	588	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)													0.4375	167.995021	168.427777	56	72	CC		KEEP	---	---	---	---	capture			Silent	SNP	87127408	87127408	15244	13	C	T	T	19	19	SLITRK5	T	1	1
CLYBL	171425	broad.mit.edu	36	13	99313268	99313268	+	Missense_Mutation	SNP	A	G	G			TCGA-19-5960-01	TCGA-19-5960-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr13:99313268A>G	uc001vok.1	+	c.461A>G	c.(460-462)CAC>CGC	p.H154R		NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like	154					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)													0.446429	76.467019	76.607098	25	31	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	99313268	99313268	3711	13	A	G	G	6	6	CLYBL	G	4	4
ZNF668	79759	broad.mit.edu	36	16	30980835	30980835	+	Silent	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:30980835C>T	uc010caf.1	-	c.915G>A	c.(913-915)GTG>GTA	p.V305V	ZNF668_uc002eao.1_Silent_p.V305V	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						Colon(181;1111 1980 5060 10512 25785)				49				0.184211	8.793652	12.377654	7	31	CC		KEEP	---	---	---	---	capture			Silent	SNP	30980835	30980835	18670	16	C	T	T	29	29	ZNF668	T	2	2
RECQL5	9400	broad.mit.edu	36	17	71136697	71136697	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:71136697G>A	uc010dgl.1	-	c.2401C>T	c.(2401-2403)CCA>TCA	p.P801S	RECQL5_uc010dgk.1_Missense_Mutation_p.P774S|RECQL5_uc002jot.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	801					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)													0.27027	27.73457	29.495386	10	27	GG		KEEP	---	---	---	---	capture	all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)		Missense_Mutation	SNP	71136697	71136697	13672	17	G	A	A	43	43	RECQL5	A	2	2
TNFRSF11A	8792	broad.mit.edu	36	18	58187644	58187644	+	Missense_Mutation	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr18:58187644C>T	uc002lin.1	+	c.1514C>T	c.(1513-1515)GCG>GTG	p.A505V	TNFRSF11A_uc010dpv.1_Intron	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	505	Cytoplasmic (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity				0		Colorectal(73;0.188)												0.870968	87.043949	91.207421	27	4	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	58187644	58187644	16825	18	C	T	T	27	27	TNFRSF11A	T	1	1
CREB3L3	84699	broad.mit.edu	36	19	4122806	4122806	+	Missense_Mutation	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:4122806C>T	uc002lzl.1	+	c.1226C>T	c.(1225-1227)GCG>GTG	p.A409V	CREB3L3_uc002lzm.1_Missense_Mutation_p.A399V	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	409	Lumenal (Potential).				regulation of transcription, DNA-dependent|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1														0.384615	57.317995	57.91362	20	32	CC		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)	Missense_Mutation	SNP	4122806	4122806	3997	19	C	T	T	27	27	CREB3L3	T	1	1
TCHH	7062	broad.mit.edu	36	1	150350026	150350026	+	Missense_Mutation	SNP	C	G	G			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150350026C>G	uc001ezp.2	-	c.2291G>C	c.(2290-2292)CGC>CCC	p.R764P	TCHH_uc009wne.1_Missense_Mutation_p.R764P	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	764					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)													0.450549	132.686573	132.888356	41	50	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.206)		Missense_Mutation	SNP	150350026	150350026	16226	1	C	G	G	27	27	TCHH	G	3	3
OBSCN	84033	broad.mit.edu	36	1	226571816	226571816	+	Missense_Mutation	SNP	G	T	T			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:226571816G>T	uc009xez.1	+	c.13590G>T	c.(13588-13590)GAG>GAT	p.E4530D	OBSCN_uc001hsn.1_Missense_Mutation_p.E4530D	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4530	Fibronectin type-III 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			large_intestine(7)|breast(5)|ovary(4)|skin(2)|stomach(1)|central_nervous_system(1)|pancreas(1)	21		Prostate(94;0.0405)								4006				0.444444	24.097142	24.145639	8	10	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	226571816	226571816	11217	1	G	T	T	35	35	OBSCN	T	3	3
MTF1	4520	broad.mit.edu	36	1	38070518	38070518	+	Missense_Mutation	SNP	C	G	G			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:38070518C>G	uc001cce.1	-	c.1054G>C	c.(1054-1056)GAA>CAA	p.E352Q	MTF1_uc009vvj.1_Missense_Mutation_p.E43Q	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	352						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)												0.52	94.95243	94.969794	26	24	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	38070518	38070518	10315	1	C	G	G	32	32	MTF1	G	3	3
BSND	7809	broad.mit.edu	36	1	55243292	55243292	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:55243292G>A	uc001cye.1	+	c.187G>A	c.(187-189)GTC>ATC	p.V63I		NM_057176	NP_476517	Q8WZ55	BSND_HUMAN	barttin	63	Cytoplasmic (Potential).					basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				ovary(1)	1						Ovarian(191;1657 2078 22894 42033 48899)								0.392857	32.819857	33.100914	11	17	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55243292	55243292	1562	1	G	A	A	40	40	BSND	A	1	1
HFM1	164045	broad.mit.edu	36	1	91613574	91613574	+	Silent	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:91613574C>T	uc001doa.2	-	c.1614G>A	c.(1612-1614)AAG>AAA	p.K538K		NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	538	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)												0.461538	97.644521	97.728184	30	35	CC		KEEP	---	---	---	---	capture		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)	Silent	SNP	91613574	91613574	7366	1	C	T	T	24	24	HFM1	T	2	2
ADNP	23394	broad.mit.edu	36	20	48942383	48942383	+	Missense_Mutation	SNP	G	T	T			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:48942383G>T	uc002xvt.1	-	c.2275C>A	c.(2275-2277)CAT>AAT	p.H759N	ADNP_uc002xvu.1_Missense_Mutation_p.H759N	NM_015339	NP_852107	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	759	Homeobox.				regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2														0.484375	88.80882	88.822805	31	33	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48942383	48942383	324	20	G	T	T	45	45	ADNP	T	3	3
TNFRSF6B	8771	broad.mit.edu	36	20	61798707	61798707	+	Missense_Mutation	SNP	T	G	G			TCGA-19-5960-01	TCGA-19-5960-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr20:61798707T>G	uc002yfy.1	+	c.143T>G	c.(142-144)GTG>GGG	p.V48G	RTEL1_uc002yfw.1_Non-coding_Transcript|RTEL1_uc002yfx.1_3'UTR|TNFRSF6B_uc002yfz.1_Missense_Mutation_p.V48G	NM_032945	NP_116563	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily,	48	TNFR-Cys 1.				anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)													0.571429	8.067931	8.094819	4	3	TT		KEEP	---	---	---	---	capture	Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)		Missense_Mutation	SNP	61798707	61798707	16839	20	T	G	G	59	59	TNFRSF6B	G	4	4
RCAN1	1827	broad.mit.edu	36	21	34812374	34812374	+	Missense_Mutation	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr21:34812374C>T	uc002yue.1	-	c.637G>A	c.(637-639)GTC>ATC	p.V213I	RCAN1_uc002yuc.1_Missense_Mutation_p.V132I|RCAN1_uc002yud.1_Missense_Mutation_p.V78I|RCAN1_uc002yub.1_Missense_Mutation_p.V158I	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	213					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0														0.444444	97.34906	97.531392	32	40	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	34812374	34812374	13637	21	C	T	T	18	18	RCAN1	T	2	2
FTCD	10841	broad.mit.edu	36	21	46383264	46383264	+	Missense_Mutation	SNP	T	C	C			TCGA-19-5960-01	TCGA-19-5960-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr21:46383264T>C	uc002zif.1	-	c.1262A>G	c.(1261-1263)GAA>GGA	p.E421G	FTCD_uc002zig.1_Missense_Mutation_p.E421G|FTCD_uc002zih.1_Missense_Mutation_p.E421G|FTCD_uc010gqf.1_Intron|FTCD_uc010gqg.1_Missense_Mutation_p.E290G|FTCD_uc002zie.1_Intron	NM_006657	NP_996848	O95954	FTCD_HUMAN	formiminotransferase cyclodeaminase	421	Cyclodeaminase/cyclohydrolase (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			pancreas(1)	1	Breast(49;0.214)				L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)									0.25	6.71718	8.202427	6	18	TT		KEEP	---	---	---	---	capture		Colorectal(79;0.235)	Missense_Mutation	SNP	46383264	46383264	6332	21	T	C	C	62	62	FTCD	C	4	4
ZDHHC8	29801	broad.mit.edu	36	22	18511184	18511184	+	Silent	SNP	C	T	T	rs34918643	unknown	TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:18511184C>T	uc002zrr.1	+	c.2031C>T	c.(2029-2031)CCC>CCT	p.P677P	ZDHHC8_uc002zrq.1_Silent_p.P677P|ZDHHC8_uc010gsa.1_Silent_p.P483P	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	677	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1	Colorectal(54;0.0993)													1	14.667905	14.607223	4	0	CC		KEEP	---	---	---	---	capture			Silent	SNP	18511184	18511184	18209	22	C	T	T	23	23	ZDHHC8	T	1	1
TTN	7273	broad.mit.edu	36	2	179141041	179141041	+	Missense_Mutation	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:179141041C>T	uc002umr.1	-	c.70360G>A	c.(70360-70362)GTC>ATC	p.V23454I	TTN_uc002ums.1_Missense_Mutation_p.V17149I|TTN_uc010frc.1_Missense_Mutation_p.V17082I|TTN_uc010frd.1_Missense_Mutation_p.V16957I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24381										ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153										8722				0.522727	70.022281	70.041843	23	21	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)		Missense_Mutation	SNP	179141041	179141041	17290	2	C	T	T	19	19	TTN	T	1	1
CERKL	375298	broad.mit.edu	36	2	182176977	182176977	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:182176977G>A	uc002unx.1	-	c.313C>T	c.(313-315)CGG>TGG	p.R105W	CERKL_uc010frk.1_Non-coding_Transcript|CERKL_uc002uny.1_Missense_Mutation_p.R105W|CERKL_uc002unz.1_De_novo_Start_InFrame|CERKL_uc002uob.1_De_novo_Start_InFrame|CERKL_uc002uoa.1_Missense_Mutation_p.R105W|CERKL_uc002uoc.1_Missense_Mutation_p.R105W|CERKL_uc002uod.1_De_novo_Start_OutOfFrame|CERKL_uc002uoe.1_Missense_Mutation_p.R105W	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	105	Nuclear localization signal 2.			KRR->GGG: Only cytoplasmic.	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|visual perception	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4														0.4	35.339411	35.58714	12	18	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(117;0.088)		Missense_Mutation	SNP	182176977	182176977	3401	2	G	A	A	40	40	CERKL	A	1	1
EPT1	85465	broad.mit.edu	36	2	26449840	26449840	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:26449840G>A	uc002rhf.2	+	c.412G>A	c.(412-414)GTG>ATG	p.V138M	EPT1_uc010eyl.1_Non-coding_Transcript	NM_033505		Q9C0D9	EPT1_HUMAN	selenoprotein I	138	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding				0														0.461538	35.896502	35.930107	12	14	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	26449840	26449840	5392	2	G	A	A	48	48	EPT1	A	2	2
CASR	846	broad.mit.edu	36	3	123485940	123485940	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:123485940G>A	uc003eew.2	+	c.2479G>A	c.(2479-2481)GTC>ATC	p.V827I	CASR_uc003eev.2_Missense_Mutation_p.V817I	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor	817	Helical; Name=6; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)	4					Cinacalcet(DB01012)									0.435484	78.677477	78.907999	27	35	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(114;0.226)	Missense_Mutation	SNP	123485940	123485940	2801	3	G	A	A	40	40	CASR	A	1	1
COL6A6	131873	broad.mit.edu	36	3	131795833	131795833	+	Missense_Mutation	SNP	G	C	C			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:131795833G>C	uc010htl.1	+	c.4489G>C	c.(4489-4491)GGG>CGG	p.G1497R	COL6A6_uc003eni.2_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6	1497	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8														0.35	66.056361	67.247771	21	39	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	131795833	131795833	3841	3	G	C	C	35	35	COL6A6	C	3	3
TP63	8626	broad.mit.edu	36	3	191069854	191069854	+	Nonsense_Mutation	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:191069854C>T	uc003fry.2	+	c.1177C>T	c.(1177-1179)CGA>TGA	p.R393*	TP63_uc003frx.2_Nonsense_Mutation_p.R393*|TP63_uc003frz.2_Nonsense_Mutation_p.R393*|TP63_uc010hzc.1_Nonsense_Mutation_p.R393*|TP63_uc003fsa.2_Nonsense_Mutation_p.R299*|TP63_uc003fsb.2_Nonsense_Mutation_p.R299*|TP63_uc003fsc.2_Nonsense_Mutation_p.R299*|TP63_uc003fsd.2_Nonsense_Mutation_p.R299*|TP63_uc010hzd.1_Nonsense_Mutation_p.R214*|TP63_uc003fse.1_Nonsense_Mutation_p.R270*	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	393					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|promoter binding|sequence-specific DNA binding transcription factor activity|transcription activator activity|transcription repressor activity			lung(4)|ovary(2)|skin(2)	8	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)									423				0.444444	22.893352	22.942283	8	10	CC		KEEP	---	---	---	---	capture	Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)	Nonsense_Mutation	SNP	191069854	191069854	16936	3	C	T	T	19	19	TP63	T	5	1
FYTTD1	84248	broad.mit.edu	36	3	198981497	198981497	+	Missense_Mutation	SNP	G	T	T			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:198981497G>T	uc003fyi.1	+	c.482G>T	c.(481-483)AGC>ATC	p.S161I	FYTTD1_uc003fyh.1_Missense_Mutation_p.S70I	NM_032288	NP_001011537	Q96QD9	UIF_HUMAN	forty-two-three domain containing 1 isoform 1	161					mRNA export from nucleus	nuclear speck	mRNA binding|protein binding				0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)												0.333333	17.543622	17.986622	6	12	GG		KEEP	---	---	---	---	capture	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)	Missense_Mutation	SNP	198981497	198981497	6378	3	G	T	T	34	34	FYTTD1	T	3	3
OXSR1	9943	broad.mit.edu	36	3	38241153	38241153	+	Missense_Mutation	SNP	T	C	C			TCGA-19-5960-01	TCGA-19-5960-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr3:38241153T>C	uc003chy.1	+	c.790T>C	c.(790-792)TTT>CTT	p.F264L	OXSR1_uc010hha.1_Missense_Mutation_p.F196L|OXSR1_uc010hhb.1_Missense_Mutation_p.F198L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	264	Protein kinase.				intracellular protein kinase cascade|protein phosphorylation|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1										232				0.543478	90.501431	90.581132	25	21	TT		KEEP	---	---	---	---	capture		KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)	Missense_Mutation	SNP	38241153	38241153	11749	3	T	C	C	52	52	OXSR1	C	4	4
TRAK1	22906	broad.mit.edu	36	3	42217446	42217446	+	Silent	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:42217446C>T	uc003cky.1	+	c.1323C>T	c.(1321-1323)TGC>TGT	p.C441C	TRAK1_uc003ckz.2_Silent_p.C367C|TRAK1_uc003cla.1_Silent_p.C383C	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	441	Interaction with HGS.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						GBM(44;195 884 22595 31865 41850)								0.466019	138.887305	138.990377	48	55	CC		KEEP	---	---	---	---	capture			Silent	SNP	42217446	42217446	16993	3	C	T	T	27	27	TRAK1	T	1	1
EGF	1950	broad.mit.edu	36	4	111115380	111115380	+	Missense_Mutation	SNP	A	T	T			TCGA-19-5960-01	TCGA-19-5960-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:111115380A>T	uc003hzy.2	+	c.1797A>T	c.(1795-1797)CAA>CAT	p.Q599H		NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor (beta-urogastrone)	599	LDL-receptor class B 7.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			central_nervous_system(1)	1		Hepatocellular(203;0.0893)			Sulindac(DB00605)					724				0.392157	61.890134	62.409109	20	31	AA		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Missense_Mutation	SNP	111115380	111115380	5151	4	A	T	T	2	2	EGF	T	4	4
FGFR4	2264	broad.mit.edu	36	5	176452375	176452375	+	Nonsense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:176452375G>A	uc003mfl.1	+	c.1041G>A	c.(1039-1041)TGG>TGA	p.W347*	FGFR4_uc003mfm.1_Nonsense_Mutation_p.W347*|FGFR4_uc003mfo.1_Nonsense_Mutation_p.W347*	NM_002011	NP_998812	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	347	Extracellular (Potential).|Ig-like C2-type 3.				insulin receptor signaling pathway|positive regulation of cell proliferation|protein phosphorylation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(10)|breast(1)|central_nervous_system(1)|skin(1)	13	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)			Palifermin(DB00039)					219	TSP Lung(9;0.080)			0.558824	56.929895	57.033809	19	15	GG		KEEP	---	---	---	---	capture	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Nonsense_Mutation	SNP	176452375	176452375	6105	5	G	A	A	42	42	FGFR4	A	5	2
C6	729	broad.mit.edu	36	5	41231784	41231784	+	Missense_Mutation	SNP	T	C	C			TCGA-19-5960-01	TCGA-19-5960-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr5:41231784T>C	uc003jml.1	-	c.481A>G	c.(481-483)ATT>GTT	p.I161V	C6_uc003jmk.2_Missense_Mutation_p.I152V	NM_001115131	NP_001108603	P13671	CO6_HUMAN	complement component 6 precursor	152	LDL-receptor class A.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)	5		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)												0.423077	66.237132	66.506367	22	30	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	41231784	41231784	2416	5	T	C	C	51	51	C6	C	4	4
C5orf34	375444	broad.mit.edu	36	5	43522953	43522953	+	Missense_Mutation	SNP	C	A	A			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:43522953C>A	uc003jnz.1	-	c.1738G>T	c.(1738-1740)GGT>TGT	p.G580C		NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	580										breast(1)	1	Lung NSC(6;2.07e-05)													0.285714	21.888138	23.042049	8	20	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	43522953	43522953	2391	5	C	A	A	21	21	C5orf34	A	3	3
DNAH8	1769	broad.mit.edu	36	6	38938158	38938158	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:38938158G>A	uc003ooe.1	+	c.5605G>A	c.(5605-5607)GTG>ATG	p.V1869M		NM_001371	NP_001362	Q96JB1	DYH8_HUMAN	dynein, axonemal, heavy polypeptide 8	1869	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(5)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	17										2979				0.862069	168.987243	176.347029	50	8	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	38938158	38938158	4790	6	G	A	A	40	40	DNAH8	A	1	1
LRFN2	57497	broad.mit.edu	36	6	40508604	40508604	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:40508604G>A	uc003oph.1	-	c.227C>T	c.(226-228)ACG>ATG	p.T76M		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	76	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)													1	53.443159	53.443129	15	0	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	40508604	40508604	9311	6	G	A	A	40	40	LRFN2	A	1	1
KIAA1147	57189	broad.mit.edu	36	7	141011487	141011487	+	Missense_Mutation	SNP	C	G	G			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:141011487C>G	uc003vwk.1	-	c.921G>C	c.(919-921)GAG>GAC	p.E307D		NM_001080392	NP_001073861	A4D1U4	LCHN_HUMAN	hypothetical protein LOC57189	307										ovary(1)	1	Melanoma(164;0.0171)													0.444444	28.79842	28.846746	8	10	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	141011487	141011487	8518	7	C	G	G	32	32	KIAA1147	G	3	3
NOS3	4846	broad.mit.edu	36	7	150326670	150326670	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:150326670G>A	uc003wif.1	+	c.785G>A	c.(784-786)CGG>CAG	p.R262Q		NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	262	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|oxidation-reduction process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)	7	all_neural(206;0.219)				L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)					755				0.285714	11.196591	11.772029	4	10	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Missense_Mutation	SNP	150326670	150326670	10947	7	G	A	A	39	39	NOS3	A	1	1
TECPR1	25851	broad.mit.edu	36	7	97700178	97700178	+	Missense_Mutation	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:97700178G>A	uc003upg.1	-	c.1715C>T	c.(1714-1716)CCG>CTG	p.P572L	TECPR1_uc003uph.1_Missense_Mutation_p.P502L	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	572						integral to membrane	protein binding			pancreas(1)	1														0.338983	57.481716	58.834229	20	39	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	97700178	97700178	16270	7	G	A	A	39	39	TECPR1	A	1	1
UBR5	51366	broad.mit.edu	36	8	103367803	103367803	+	Missense_Mutation	SNP	C	G	G			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:103367803C>G	uc003ykr.1	-	c.5176G>C	c.(5176-5178)GCA>CCA	p.A1726P	UBR5_uc003yks.1_Missense_Mutation_p.A1726P	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1726					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(5)|ovary(3)|large_intestine(3)|kidney(1)|central_nervous_system(1)	13	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)					Ovarian(131;96 1741 5634 7352 27489)				1024				0.151515	7.251482	11.092402	5	28	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(57;0.000442)		Missense_Mutation	SNP	103367803	103367803	17463	8	C	G	G	28	28	UBR5	G	3	3
NRBP2	340371	broad.mit.edu	36	8	144990027	144990027	+	Missense_Mutation	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:144990027C>T	uc003yzw.1	-	c.764G>A	c.(763-765)AGC>AAC	p.S255N	NRBP2_uc003yzv.2_Missense_Mutation_p.S220N|NRBP2_uc010mfl.1_Silent_p.Q285Q|NRBP2_uc010mfm.1_Intron|NRBP2_uc003yzx.1_Non-coding_Transcript|NRBP2_uc003yzy.1_Missense_Mutation_p.S220N|NRBP2_uc003yzz.1_Silent_p.Q143Q	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	463					negative regulation of neuron apoptosis|neuron differentiation|protein phosphorylation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)									69				0.375	7.42122	7.531578	3	5	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)		Missense_Mutation	SNP	144990027	144990027	11048	8	C	T	T	28	28	NRBP2	T	2	2
TPD52	7163	broad.mit.edu	36	8	81117425	81117425	+	Silent	SNP	C	T	T			TCGA-19-5960-01	TCGA-19-5960-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:81117425C>T	uc003ybr.1	-	c.540G>A	c.(538-540)AAG>AAA	p.K180K	TPD52_uc010lzr.1_Non-coding_Transcript|TPD52_uc003ybq.1_Non-coding_Transcript|TPD52_uc010lzs.1_Non-coding_Transcript|TPD52_uc003ybs.1_Silent_p.K163K|TPD52_uc003ybt.1_Silent_p.K140K|TPD52_uc003ybu.1_Non-coding_Transcript	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	180					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)												0.361111	42.165917	42.776877	13	23	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)		Silent	SNP	81117425	81117425	16941	8	C	T	T	24	24	TPD52	T	2	2
TRAF2	7186	broad.mit.edu	36	9	138938270	138938270	+	Silent	SNP	G	A	A			TCGA-19-5960-01	TCGA-19-5960-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:138938270G>A	uc010nbu.1	+	c.1284G>A	c.(1282-1284)CAG>CAA	p.Q428Q	TRAF2_uc004cjv.1_Silent_p.Q428Q|TRAF2_uc010nbw.1_Silent_p.Q403Q	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	428	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell activation|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)								212				0.375	23.544578	23.882143	9	15	GG		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)	Silent	SNP	138938270	138938270	16982	9	G	A	A	33	33	TRAF2	A	2	2
C10orf76	79591	broad.mit.edu	36	10	103706414	103706414	+	Frame_Shift_Del	DEL	G	-	-			TCGA-19-5960-01	TCGA-19-5960-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:103706414_103706414delG	uc009xwy.1	-	c.1635_1635delC	c.(1633-1635)CCCfs	p.P545fs	C10orf76_uc009xwx.1_Non-coding_Transcript	NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	545						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)										0.76			22	7				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	103706414	103706414	1653	10	G	-	-	47	47	C10orf76	-	5	5
