Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
ADM	133	broad.mit.edu	36	11	10283872	10283872	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:10283872C>T	uc001mik.1	+	c.49C>T	c.(49-51)CTA>TTA	p.L17L	ADM_uc001mil.1_Silent_p.L17L|ADM_uc001mim.1_5'UTR	NM_001124	NP_001115	P35318	ADML_HUMAN	adrenomedullin	17					blood circulation|cAMP biosynthetic process|female pregnancy|negative regulation of vasoconstriction|progesterone biosynthetic process|response to wounding	cytoplasm|extracellular space|soluble fraction	hormone activity			central_nervous_system(1)	1														0.240964	52.157312	57.239145	20	63	CC		KEEP	---	---	---	---	capture		all cancers(16;3.51e-65)|Epithelial(150;1.52e-62)|BRCA - Breast invasive adenocarcinoma(625;0.0257)	Silent	SNP	10283872	10283872	322	11	C	T	T	24	24	ADM	T	2	2
FOXRED1	55572	broad.mit.edu	36	11	125651501	125651501	+	Missense_Mutation	SNP	A	G	G			TCGA-27-2518-01	TCGA-27-2518-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr11:125651501A>G	uc001qdi.1	+	c.974A>G	c.(973-975)TAT>TGT	p.Y325C	FOXRED1_uc001qdj.1_Missense_Mutation_p.Y114C|FOXRED1_uc001qdk.1_Missense_Mutation_p.Y114C	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	325					oxidation-reduction process	integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)												0.136364	8.491774	17.056283	9	57	AA		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)	Missense_Mutation	SNP	125651501	125651501	6279	11	A	G	G	16	16	FOXRED1	G	4	4
CHST1	8534	broad.mit.edu	36	11	45627880	45627880	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:45627880C>T	uc001mys.1	-	c.1170G>A	c.(1168-1170)TCG>TCA	p.S390S	CHST1_uc009ykv.1_Silent_p.S390S	NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	390	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			pancreas(1)	1														0.188312	62.389616	76.390289	29	125	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)	Silent	SNP	45627880	45627880	3531	11	C	T	T	23	23	CHST1	T	1	1
OR51B6	390058	broad.mit.edu	36	11	5330147	5330147	+	Missense_Mutation	SNP	C	A	A			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:5330147C>A	uc001mar.1	+	c.834C>A	c.(832-834)CAC>CAA	p.H278Q	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)												0.111111	31.005843	72.747339	31	248	CC		KEEP	---	---	---	---	capture		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Missense_Mutation	SNP	5330147	5330147	11502	11	C	A	A	20	20	OR51B6	A	3	3
OR4P4	81300	broad.mit.edu	36	11	55163185	55163185	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:55163185C>T	uc001nhr.1	+	c.776C>T	c.(775-777)CCG>CTG	p.P259L		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1														0.262963	197.515698	211.227049	71	199	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55163185	55163185	11490	11	C	T	T	23	23	OR4P4	T	1	1
OR6Q1	219952	broad.mit.edu	36	11	57555173	57555173	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:57555173G>A	uc001nmk.1	+	c.173G>A	c.(172-174)CGG>CAG	p.R58Q	OR9Q1_uc001nmj.1_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)												0.08805	8.413874	62.859595	28	290	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	57555173	57555173	11619	11	G	A	A	39	39	OR6Q1	A	1	1
PLAC1L	219990	broad.mit.edu	36	11	59564498	59564498	+	De_novo_Start_InFrame	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:59564498C>T	uc001nol.1	+	c.-10C>T	c.(-12--8)GACGA>GATGA			NM_173801	NP_776162			placenta-specific 1-like							extracellular region				ovary(2)	2														0.211207	111.249378	129.142448	49	183	CC		KEEP	---	---	---	---	capture			De_novo_Start_InFrame	SNP	59564498	59564498	12439	11	C	T	T	19	19	PLAC1L	T	5	1
SLC22A11	55867	broad.mit.edu	36	11	64086134	64086134	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:64086134G>A	uc001oai.1	+	c.580G>A	c.(580-582)GTC>ATC	p.V194I	SLC22A11_uc001oaj.1_Missense_Mutation_p.V194I|SLC22A11_uc009ypq.1_Missense_Mutation_p.V194I|SLC22A11_uc001oah.1_Missense_Mutation_p.R159H|SLC22A11_uc001oak.1_Missense_Mutation_p.V23I	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	194	Helical; (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)							OREG0004030	type=REGULATORY REGION|Gene=SLC22A11|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0.328358	59.434649	61.180996	22	45	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	64086134	64086134	14938	11	G	A	A	40	40	SLC22A11	A	1	1
C12orf51	283450	broad.mit.edu	36	12	111157279	111157279	+	Missense_Mutation	SNP	A	G	G			TCGA-27-2518-01	TCGA-27-2518-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:111157279A>G	uc009zwc.1	-	c.4634T>C	c.(4633-4635)CTC>CCC	p.L1545P		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)	1														0.833333	8.785343	9.344667	5	1	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	111157279	111157279	1740	12	A	G	G	11	11	C12orf51	G	4	4
GLT1D1	144423	broad.mit.edu	36	12	127926474	127926474	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:127926474G>A	uc001uhx.1	+	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	GLT1D1_uc001uhy.1_Non-coding_Transcript	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	44					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)													0.161765	101.860099	138.816545	55	285	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)	Missense_Mutation	SNP	127926474	127926474	6733	12	G	A	A	37	37	GLT1D1	A	1	1
PRPF40B	25766	broad.mit.edu	36	12	48316876	48316876	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:48316876C>T	uc001rur.1	+	c.1471C>T	c.(1471-1473)CGC>TGC	p.R491C	PRPF40B_uc001rup.1_Missense_Mutation_p.R513C|PRPF40B_uc001ruq.1_Missense_Mutation_p.R485C|PRPF40B_uc001rus.1_Missense_Mutation_p.R434C	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	491					mRNA processing|RNA splicing	nuclear speck				ovary(1)|kidney(1)|pancreas(1)	3												OREG0021797	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.173611	47.600303	62.073696	25	119	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48316876	48316876	13015	12	C	T	T	19	19	PRPF40B	T	1	1
AGAP2	116986	broad.mit.edu	36	12	56409697	56409697	+	Missense_Mutation	SNP	T	C	C			TCGA-27-2518-01	TCGA-27-2518-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr12:56409697T>C	uc001spq.1	-	c.2549A>G	c.(2548-2550)CAG>CGG	p.Q850R	AGAP2_uc001spp.1_Missense_Mutation_p.Q849R|AGAP2_uc001spr.1_Missense_Mutation_p.Q514R	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	850	PH.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5										257				0.18863	59.427374	95.920559	73	314	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	56409697	56409697	370	12	T	C	C	55	55	AGAP2	C	4	4
LEMD3	23592	broad.mit.edu	36	12	63850549	63850549	+	Silent	SNP	C	A	A			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:63850549C>A	uc001ssl.1	+	c.906C>A	c.(904-906)GCC>GCA	p.A302A	LEMD3_uc009zqo.1_Silent_p.A302A	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	302					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4														0.236364	33.698873	37.158016	13	42	CC		KEEP	---	---	---	---	capture	LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)	Silent	SNP	63850549	63850549	9045	12	C	A	A	23	23	LEMD3	A	3	3
F7	2155	broad.mit.edu	36	13	112819871	112819871	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr13:112819871C>T	uc001vsv.1	+	c.765C>T	c.(763-765)TTC>TTT	p.F255F	F7_uc001vsw.1_Silent_p.F233F	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	255	Peptidase S1.				anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)			Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)									0.17734	63.664064	83.599627	36	167	CC		KEEP	---	---	---	---	capture	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Silent	SNP	112819871	112819871	5543	13	C	T	T	31	31	F7	T	1	1
AHNAK2	113146	broad.mit.edu	36	14	104489854	104489854	+	Silent	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:104489854G>A	uc010axc.1	-	c.2979C>T	c.(2977-2979)GCC>GCT	p.A993A	AHNAK2_uc001ypx.2_Silent_p.A893A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	993						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)												0.328846	461.235362	474.746834	171	349	GG		KEEP	---	---	---	---	capture	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)		Silent	SNP	104489854	104489854	418	14	G	A	A	47	47	AHNAK2	A	2	2
ACTR10	55860	broad.mit.edu	36	14	57736723	57736723	+	Missense_Mutation	SNP	A	G	G			TCGA-27-2518-01	TCGA-27-2518-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr14:57736723A>G	uc001xdf.1	+	c.35A>G	c.(34-36)GAG>GGG	p.E12G	ACTR10_uc001xdh.1_5'UTR|ACTR10_uc001xdg.1_5'UTR	NM_018477	NP_060947	Q9NZ32	ARP10_HUMAN	uncharacterized hypothalamus protein HARP11	12						cytoplasm				central_nervous_system(1)	1														0.222222	7.293008	8.569875	4	14	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	57736723	57736723	209	14	A	G	G	11	11	ACTR10	G	4	4
SYNM	23336	broad.mit.edu	36	15	97488728	97488728	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:97488728C>T	uc002bup.1	+	c.2640C>T	c.(2638-2640)GAC>GAT	p.D880D	SYNM_uc002buo.1_Silent_p.D880D|SYNM_uc002buq.1_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	880	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						Pancreas(125;1071 1762 21750 40003 40381)								0.16129	9.486518	12.844954	5	26	CC		KEEP	---	---	---	---	capture			Silent	SNP	97488728	97488728	15976	15	C	T	T	19	19	SYNM	T	1	1
SPNS1	83985	broad.mit.edu	36	16	28894164	28894164	+	Missense_Mutation	SNP	T	G	G			TCGA-27-2518-01	TCGA-27-2518-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr16:28894164T>G	uc002drw.1	+	c.326T>G	c.(325-327)GTG>GGG	p.V109G	SPNS1_uc002drx.1_5'UTR|SPNS1_uc002dry.1_Missense_Mutation_p.V64G|SPNS1_uc002dsa.1_Missense_Mutation_p.V64G|SPNS1_uc002drz.1_Missense_Mutation_p.V64G|SPNS1_uc010byp.1_Missense_Mutation_p.V64G|SPNS1_uc010byq.1_5'UTR	NM_032038	NP_114427	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	64	Helical; (Potential).				lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0														0.294118	9.829842	10.502051	5	12	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	28894164	28894164	15587	16	T	G	G	59	59	SPNS1	G	4	4
SEZ6L2	26470	broad.mit.edu	36	16	29792363	29792363	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:29792363C>T	uc002duq.2	-	c.2293G>A	c.(2293-2295)GCC>ACC	p.A765T	BOLA2_uc010bzb.1_Intron|BOLA2_uc010bzc.1_Intron|SEZ6L2_uc002dup.2_Missense_Mutation_p.A695T|SEZ6L2_uc002dur.2_Missense_Mutation_p.A695T|SEZ6L2_uc002dus.2_Missense_Mutation_p.A651T	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	765	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)	1														0.189873	30.175064	37.284476	15	64	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	29792363	29792363	14633	16	C	T	T	27	27	SEZ6L2	T	1	1
CMTM2	146225	broad.mit.edu	36	16	65171183	65171183	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:65171183C>T	uc002ept.1	+	c.172C>T	c.(172-174)CCC>TCC	p.P58S	CMTM2_uc010cdu.1_Missense_Mutation_p.P58S	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	58					chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)												0.320388	86.142311	89.092534	33	70	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)	Missense_Mutation	SNP	65171183	65171183	3721	16	C	T	T	26	26	CMTM2	T	2	2
GRIN2A	2903	broad.mit.edu	36	16	9764949	9764949	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:9764949C>T	uc002czp.1	-	c.3953G>A	c.(3952-3954)CGG>CAG	p.R1318Q	GRIN2A_uc002czq.1_Missense_Mutation_p.R1318Q|GRIN2A_uc002czr.2_Intron|GRIN2A_uc002czo.2_5'Flank	NM_000833	NP_000824	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1318	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)					324				0.116	34.406351	70.68796	29	221	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	9764949	9764949	7058	16	C	T	T	23	23	GRIN2A	T	1	1
MNT	4335	broad.mit.edu	36	17	2237491	2237491	+	Missense_Mutation	SNP	C	G	G			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:2237491C>G	uc002fur.1	-	c.1203G>C	c.(1201-1203)CAG>CAC	p.Q401H		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	401					multicellular organismal development|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulator activity				0														0.277778	7.741066	8.56184	5	13	CC		KEEP	---	---	---	---	capture		Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)	Missense_Mutation	SNP	2237491	2237491	10069	17	C	G	G	28	28	MNT	G	3	3
KRT34	3885	broad.mit.edu	36	17	36788929	36788929	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:36788929G>A	uc002hwm.1	-	c.1028C>T	c.(1027-1029)ACG>ATG	p.T343M		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	343	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)												0.31	77.97763	81.200012	31	69	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	36788929	36788929	8786	17	G	A	A	40	40	KRT34	A	1	1
SERPINB13	5275	broad.mit.edu	36	18	59406900	59406900	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr18:59406900G>A	uc002ljc.1	+	c.19G>A	c.(19-21)GTC>ATC	p.V7I	SERPINB13_uc002ljd.1_5'UTR	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	7					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1														0.36413	189.875875	192.863605	67	117	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	59406900	59406900	14588	18	G	A	A	40	40	SERPINB13	A	1	1
SLC1A6	6511	broad.mit.edu	36	19	14928440	14928440	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:14928440C>T	uc002naa.1	-	c.1017G>A	c.(1015-1017)CTG>CTA	p.L339L	SLC1A6_uc010dzu.1_Intron	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	339					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)	5					L-Glutamic Acid(DB00142)									0.177083	32.1423	41.558689	17	79	CC		KEEP	---	---	---	---	capture			Silent	SNP	14928440	14928440	14932	19	C	T	T	21	21	SLC1A6	T	2	2
KCNN1	3780	broad.mit.edu	36	19	17945899	17945899	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:17945899G>A	uc002nht.1	+	c.202G>A	c.(202-204)GAT>AAT	p.D68N		NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	68					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0														0.294118	39.406629	41.340342	15	36	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	17945899	17945899	8383	19	G	A	A	37	37	KCNN1	A	1	1
PRX	57716	broad.mit.edu	36	19	45592174	45592174	+	Missense_Mutation	SNP	G	C	C			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:45592174G>C	uc002onr.1	-	c.3925C>G	c.(3925-3927)CCC>GCC	p.P1309A	PRX_uc002onq.1_Missense_Mutation_p.P1170A|PRX_uc002ons.1_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1309					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2														0.333333	7.704347	7.995526	4	8	GG		KEEP	---	---	---	---	capture	Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)		Missense_Mutation	SNP	45592174	45592174	13093	19	G	C	C	42	42	PRX	C	3	3
MEGF8	1954	broad.mit.edu	36	19	47565648	47565648	+	Missense_Mutation	SNP	A	C	C			TCGA-27-2518-01	TCGA-27-2518-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr19:47565648A>C	uc002otl.2	+	c.6566A>C	c.(6565-6567)AAC>ACC	p.N2189T	MEGF8_uc002otm.2_Missense_Mutation_p.N1797T|MEGF8_uc002otn.2_5'UTR	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2256	Extracellular (Potential).|Laminin EGF-like 3.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)												0.277778	6.762442	7.64866	5	13	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	47565648	47565648	9852	19	A	C	C	2	2	MEGF8	C	4	4
SIGLEC5	8778	broad.mit.edu	36	19	56807455	56807455	+	Silent	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:56807455G>A	uc002pxe.1	-	c.1497C>T	c.(1495-1497)CCC>CCT	p.P499P		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	499	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(1)	2		all_neural(266;0.0726)												0.191057	109.420945	131.332099	47	199	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)	Silent	SNP	56807455	56807455	14806	19	G	A	A	39	39	SIGLEC5	A	1	1
NLRP5	126206	broad.mit.edu	36	19	61207020	61207020	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:61207020C>T	uc002qmj.1	+	c.189C>T	c.(187-189)TAC>TAT	p.Y63Y	NLRP5_uc002qmi.1_Silent_p.Y63Y	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	63	DAPIN.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)	6		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)												0.213992	118.572344	136.927109	52	191	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(193;0.0326)	Silent	SNP	61207020	61207020	10883	19	C	T	T	19	19	NLRP5	T	1	1
CLEC4M	10332	broad.mit.edu	36	19	7739731	7739731	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:7739731C>T	uc002mib.1	+	c.1057C>T	c.(1057-1059)CGG>TGG	p.R353W	CLEC4M_uc002mhz.1_Missense_Mutation_p.A223V|CLEC4M_uc002mia.1_Missense_Mutation_p.R217W|CLEC4M_uc010dvs.1_Missense_Mutation_p.R329W|CLEC4M_uc002mic.1_Missense_Mutation_p.A287V|CLEC4M_uc010dvt.1_Missense_Mutation_p.R330W|CLEC4M_uc002mie.1_3'UTR|CLEC4M_uc002mif.1_3'UTR|CLEC4M_uc002mig.1_3'UTR|CLEC4M_uc002mih.1_Missense_Mutation_p.R330W|CLEC4M_uc002mii.1_Missense_Mutation_p.R72W	NM_214675	NP_999840	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	353	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1														0.101695	9.511622	37.533042	18	159	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	7739731	7739731	3656	19	C	T	T	27	27	CLEC4M	T	1	1
SLC26A9	115019	broad.mit.edu	36	1	204157509	204157509	+	Silent	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:204157509G>A	uc001hdp.1	-	c.1863C>T	c.(1861-1863)AGC>AGT	p.S621S	SLC26A9_uc001hdo.1_Silent_p.S289S|SLC26A9_uc001hdq.1_Silent_p.S621S	NM_134325	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform b	621	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)	1	Breast(84;0.201)													0.458333	32.42607	32.461761	11	13	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(75;0.0458)		Silent	SNP	204157509	204157509	15021	1	G	A	A	38	38	SLC26A9	A	1	1
SKI	6497	broad.mit.edu	36	1	2150876	2150876	+	Missense_Mutation	SNP	A	C	C			TCGA-27-2518-01	TCGA-27-2518-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr1:2150876A>C	uc001aja.2	+	c.811A>C	c.(811-813)ACC>CCC	p.T271P		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	271					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)					Ovarian(177;144 1678 13697 20086 27838 40755)								0.210526	7.292284	8.763995	4	15	AA		KEEP	---	---	---	---	capture		Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)	Missense_Mutation	SNP	2150876	2150876	14852	1	A	C	C	10	10	SKI	C	4	4
WDR64	128025	broad.mit.edu	36	1	240026288	240026288	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:240026288G>A	uc001hzf.1	+	c.1814G>A	c.(1813-1815)CGT>CAT	p.R605H	WDR64_uc001hzg.1_Missense_Mutation_p.R518H	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	1052											0	Ovarian(103;0.103)	all_cancers(173;0.0121)												0.2125	35.835035	41.945309	17	63	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.0116)		Missense_Mutation	SNP	240026288	240026288	17888	1	G	A	A	40	40	WDR64	A	1	1
HPCAL4	51440	broad.mit.edu	36	1	39922737	39922737	+	Silent	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:39922737G>A	uc001cdr.1	-	c.126C>T	c.(124-126)ATC>ATT	p.I42I		NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	42	EF-hand 1.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)												0.184211	14.407176	17.958642	7	31	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Silent	SNP	39922737	39922737	7623	1	G	A	A	41	41	HPCAL4	A	2	2
ELTD1	64123	broad.mit.edu	36	1	79155953	79155953	+	Missense_Mutation	SNP	T	C	C			TCGA-27-2518-01	TCGA-27-2518-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:79155953T>C	uc001diq.2	-	c.1703A>G	c.(1702-1704)AAC>AGC	p.N568S		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	568	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)	1														0.117647	13.953572	23.721898	8	60	TT		KEEP	---	---	---	---	capture		COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)	Missense_Mutation	SNP	79155953	79155953	5276	1	T	C	C	60	60	ELTD1	C	4	4
SALL4	57167	broad.mit.edu	36	20	49840916	49840916	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:49840916C>T	uc002xwh.2	-	c.1513G>A	c.(1513-1515)GGT>AGT	p.G505S	SALL4_uc010gii.1_Intron|SALL4_uc002xwi.2_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	505					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2														0.287009	247.521899	260.974652	95	236	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	49840916	49840916	14293	20	C	T	T	23	23	SALL4	T	1	1
ZGPAT	84619	broad.mit.edu	36	20	61836439	61836439	+	Splice_Site_SNP	SNP	A	C	C			TCGA-27-2518-01	TCGA-27-2518-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr20:61836439A>C	uc002ygk.2	+	c.872_splice	c.e5-2	p.V291_splice	ZGPAT_uc002ygi.2_Intron|ZGPAT_uc002ygj.2_Intron|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Intron|ZGPAT_uc002ygm.2_Intron|ZGPAT_uc002ygn.2_Intron|LIME1_uc002ygo.2_5'Flank|LIME1_uc002ygp.2_5'Flank	NM_032527	NP_115916			zinc finger, CCCH-type with G patch domain						negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)													0.313869	247.872128	256.308576	86	188	AA		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	61836439	61836439	18265	20	A	C	C	7	7	ZGPAT	C	5	4
NRIP1	8204	broad.mit.edu	36	21	15261154	15261154	+	Missense_Mutation	SNP	G	T	T			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr21:15261154G>T	uc002yjx.1	-	c.1231C>A	c.(1231-1233)CCT>ACT	p.P411T	NRIP1_uc010gkz.1_Missense_Mutation_p.P411T	NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	411	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0														0.101156	26.529133	81.399026	35	311	GG		KEEP	---	---	---	---	capture		Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)	Missense_Mutation	SNP	15261154	15261154	11057	21	G	T	T	44	44	NRIP1	T	3	3
IL17RA	23765	broad.mit.edu	36	22	15969845	15969845	+	Missense_Mutation	SNP	T	G	G			TCGA-27-2518-01	TCGA-27-2518-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr22:15969845T>G	uc002zly.1	+	c.1736T>G	c.(1735-1737)GTC>GGC	p.V579G	IL17RA_uc010gqt.1_Missense_Mutation_p.V527G	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	579	Cytoplasmic (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)												0.25	6.41876	7.101133	3	9	TT		KEEP	---	---	---	---	capture		Colorectal(9;0.241)	Missense_Mutation	SNP	15969845	15969845	7940	22	T	G	G	58	58	IL17RA	G	4	4
TUBA8	51807	broad.mit.edu	36	22	16989536	16989536	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:16989536G>A	uc002znw.1	+	c.863G>A	c.(862-864)CGC>CAC	p.R288H	TUBA8_uc002znr.2_Missense_Mutation_p.R198H|TUBA8_uc002znv.1_Missense_Mutation_p.R264H|TUBA8_uc002znx.1_Missense_Mutation_p.R111H	NM_018943	NP_061816	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	264					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0														0.113043	12.108216	29.092886	13	102	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	16989536	16989536	17305	22	G	A	A	38	38	TUBA8	A	1	1
SCUBE1	80274	broad.mit.edu	36	22	41930070	41930070	+	Silent	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:41930070G>A	uc003bdt.1	-	c.2844C>T	c.(2842-2844)GAC>GAT	p.D948D		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	948					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)	4		all_neural(38;0.0414)|Ovarian(80;0.07)												0.099291	7.340045	29.981952	14	127	GG		KEEP	---	---	---	---	capture			Silent	SNP	41930070	41930070	14427	22	G	A	A	40	40	SCUBE1	A	1	1
KLF11	8462	broad.mit.edu	36	2	10103864	10103864	+	Missense_Mutation	SNP	G	T	T			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:10103864G>T	uc002raf.1	+	c.179G>T	c.(178-180)AGA>ATA	p.R60I		NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	60					apoptosis|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	promoter binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					Melanoma(56;431 1507 23687 50789)								0.35	71.868425	73.459805	28	52	GG		KEEP	---	---	---	---	capture		Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)	Missense_Mutation	SNP	10103864	10103864	8651	2	G	T	T	33	33	KLF11	T	3	3
DPP10	57628	broad.mit.edu	36	2	116251338	116251338	+	Missense_Mutation	SNP	C	A	A			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:116251338C>A	uc002tla.1	+	c.1306C>A	c.(1306-1308)CAA>AAA	p.Q436K	DPP10_uc002tlb.1_Missense_Mutation_p.Q386K|DPP10_uc002tlc.1_Missense_Mutation_p.Q432K|DPP10_uc002tle.1_Missense_Mutation_p.Q386K|DPP10_uc002tlf.1_Missense_Mutation_p.Q429K	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	436	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|breast(1)|skin(1)	9														0.308511	80.036839	83.110467	29	65	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	116251338	116251338	4911	2	C	A	A	29	29	DPP10	A	3	3
LAPTM4A	9741	broad.mit.edu	36	2	20104238	20104238	+	Missense_Mutation	SNP	T	A	A			TCGA-27-2518-01	TCGA-27-2518-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:20104238T>A	uc002rdm.1	-	c.127A>T	c.(127-129)ATG>TTG	p.M43L	LAPTM4A_uc002rdn.1_Missense_Mutation_p.M1L	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	43	Helical; (Potential).				transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					Ovarian(90;1240 1386 7711 14384 46863)								0.328431	188.055112	193.379526	67	137	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	20104238	20104238	8947	2	T	A	A	50	50	LAPTM4A	A	4	4
CRYBA2	1412	broad.mit.edu	36	2	219565119	219565119	+	Missense_Mutation	SNP	G	C	C			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:219565119G>C	uc002vjj.1	-	c.252C>G	c.(250-252)AGC>AGG	p.S84R	CRYBA2_uc002vjk.1_Missense_Mutation_p.S84R	NM_057094	NP_476435	P53672	CRBA2_HUMAN	crystallin, beta A2	84	Beta/gamma crystallin 'Greek key' 2.						structural constituent of eye lens				0		Renal(207;0.0474)												0.266667	7.891424	8.630898	4	11	GG		KEEP	---	---	---	---	capture		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	Missense_Mutation	SNP	219565119	219565119	4047	2	G	C	C	46	46	CRYBA2	C	3	3
SPEG	10290	broad.mit.edu	36	2	220037418	220037418	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:220037418G>A	uc010fwg.1	+	c.2725G>A	c.(2725-2727)GTG>ATG	p.V909M	SPEG_uc002vlm.2_Non-coding_Transcript|SPEG_uc010fwh.1_Missense_Mutation_p.V117M|SPEG_uc002vln.1_Missense_Mutation_p.V117M|SPEG_uc002vlp.1_Missense_Mutation_p.V117M|SPEG_uc002vlq.2_Missense_Mutation_p.V60M	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	909	Ig-like 3.				muscle organ development|negative regulation of cell proliferation|protein phosphorylation	nucleus	ATP binding|protein serine/threonine kinase activity			ovary(4)|stomach(2)|central_nervous_system(1)	7		Renal(207;0.0183)								482				0.115702	13.273027	30.866977	14	107	GG		KEEP	---	---	---	---	capture		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)	Missense_Mutation	SNP	220037418	220037418	15548	2	G	A	A	40	40	SPEG	A	1	1
PROM2	150696	broad.mit.edu	36	2	95310768	95310768	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:95310768C>T	uc002suh.1	+	c.1479C>T	c.(1477-1479)TTC>TTT	p.F493F	PROM2_uc002suk.2_Silent_p.F493F|PROM2_uc002sui.1_Silent_p.F493F|PROM2_uc002suj.1_Silent_p.F147F|PROM2_uc002sul.1_Silent_p.F19F|PROM2_uc002sum.1_Non-coding_Transcript	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2	493	Helical; (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1														0.32716	144.315772	148.610045	53	109	CC		KEEP	---	---	---	---	capture			Silent	SNP	95310768	95310768	12999	2	C	T	T	31	31	PROM2	T	1	1
HPS3	84343	broad.mit.edu	36	3	150351112	150351112	+	Silent	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:150351112G>A	uc003ewu.1	+	c.1200G>A	c.(1198-1200)GCG>GCA	p.A400A	HPS3_uc003ewt.1_Silent_p.A400A	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	400						cytoplasm				ovary(5)|large_intestine(1)	6														0.110236	15.15986	34.247181	14	113	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Silent	SNP	150351112	150351112	7632	3	G	A	A	39	39	HPS3	A	1	1
CP	1356	broad.mit.edu	36	3	150407958	150407958	+	Missense_Mutation	SNP	G	T	T			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:150407958G>T	uc003ewy.2	-	c.918C>A	c.(916-918)AAC>AAA	p.N306K	CP_uc003ewx.2_Missense_Mutation_p.N87K|CP_uc003ewz.2_Missense_Mutation_p.N306K|CP_uc010hvf.1_Missense_Mutation_p.N32K	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	306	F5/8 type A 1.|Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|oxidation-reduction process|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)			Drotrecogin alfa(DB00055)									0.234637	103.378914	114.897707	42	137	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Missense_Mutation	SNP	150407958	150407958	3925	3	G	T	T	48	48	CP	T	3	3
SAMD7	344658	broad.mit.edu	36	3	171136894	171136894	+	Missense_Mutation	SNP	G	C	C			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:171136894G>C	uc003fgd.1	+	c.1115G>C	c.(1114-1116)GGA>GCA	p.G372A	SAMD7_uc003fge.1_Missense_Mutation_p.G372A	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	372	SAM.									skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)													0.221154	65.471346	72.91532	23	81	GG		KEEP	---	---	---	---	capture	Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)		Missense_Mutation	SNP	171136894	171136894	14304	3	G	C	C	41	41	SAMD7	C	3	3
FAM19A1	407738	broad.mit.edu	36	3	68549242	68549242	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:68549242C>T	uc003dnd.1	+	c.241C>T	c.(241-243)CGG>TGG	p.R81W	FAM19A1_uc003dne.1_Missense_Mutation_p.R81W|FAM19A1_uc003dng.1_Missense_Mutation_p.R81W	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	81						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)												0.281481	98.488636	104.285667	38	97	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)	Missense_Mutation	SNP	68549242	68549242	5745	3	C	T	T	23	23	FAM19A1	T	1	1
PCDHB12	56124	broad.mit.edu	36	5	140569686	140569686	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140569686C>T	uc003liz.1	+	c.1023C>T	c.(1021-1023)AAC>AAT	p.N341N		NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	341	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(1)	1														0.361702	145.018278	147.378016	51	90	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)		Silent	SNP	140569686	140569686	11957	5	C	T	T	19	19	PCDHB12	T	1	1
GFPT2	9945	broad.mit.edu	36	5	179664390	179664390	+	Silent	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:179664390G>A	uc003mlw.1	-	c.1830C>T	c.(1828-1830)GTC>GTT	p.V610V		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	610	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)	1	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)			L-Glutamine(DB00130)									0.305556	222.683822	232.401697	88	200	GG		KEEP	---	---	---	---	capture	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Silent	SNP	179664390	179664390	6614	5	G	A	A	45	45	GFPT2	A	2	2
GFPT2	9945	broad.mit.edu	36	5	179664528	179664528	+	Silent	SNP	G	C	C			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:179664528G>C	uc003mlw.1	-	c.1692C>G	c.(1690-1692)ACC>ACG	p.T564T		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	564	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)	1	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)			L-Glutamine(DB00130)									0.32491	251.841231	259.383789	90	187	GG		KEEP	---	---	---	---	capture	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Silent	SNP	179664528	179664528	6614	5	G	C	C	35	35	GFPT2	C	3	3
VARS2	57176	broad.mit.edu	36	6	30991786	30991786	+	Missense_Mutation	SNP	G	T	T			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:30991786G>T	uc003nsc.1	+	c.556G>T	c.(556-558)GCA>TCA	p.A186S	VARS2_uc003nsd.1_Missense_Mutation_p.A186S	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	186					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4														0.310263	354.986833	368.428911	130	289	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	30991786	30991786	17689	6	G	T	T	46	46	VARS2	T	3	3
MDN1	23195	broad.mit.edu	36	6	90459560	90459560	+	Missense_Mutation	SNP	C	G	G			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:90459560C>G	uc003pnn.1	-	c.9910G>C	c.(9910-9912)GAT>CAT	p.D3304H		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3304					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)	8		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)												0.142857	8.017	13.191241	6	36	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(108;0.0193)	Missense_Mutation	SNP	90459560	90459560	9804	6	C	G	G	30	30	MDN1	G	3	3
CLCN1	1180	broad.mit.edu	36	7	142757691	142757691	+	Missense_Mutation	SNP	G	C	C			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:142757691G>C	uc003wcr.1	+	c.2508G>C	c.(2506-2508)AAG>AAC	p.K836N		NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	836	CBS 2.|Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)|breast(1)|central_nervous_system(1)	3	Melanoma(164;0.205)													0.135338	31.553472	48.695054	18	115	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	142757691	142757691	3598	7	G	C	C	35	35	CLCN1	C	3	3
PLEC	5339	broad.mit.edu	36	8	145064356	145064356	+	Missense_Mutation	SNP	A	G	G			TCGA-27-2518-01	TCGA-27-2518-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr8:145064356A>G	uc003zaf.1	-	c.12032T>C	c.(12031-12033)CTC>CCC	p.L4011P	PLEC_uc003zag.1_Missense_Mutation_p.L3852P|PLEC_uc003zah.1_Missense_Mutation_p.L3860P|PLEC_uc003zai.1_Missense_Mutation_p.L3901P|PLEC_uc003zaj.1_Missense_Mutation_p.L3901P|PLEC_uc003zab.1_Missense_Mutation_p.L3874P|PLEC_uc003zac.1_Missense_Mutation_p.L3878P|PLEC_uc003zad.1_Missense_Mutation_p.L3874P|PLEC_uc003zae.1_Missense_Mutation_p.L3842P	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin 1 isoform 6	4011	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|central_nervous_system(1)	7														0.3	7.52092	7.878435	3	7	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	145064356	145064356	12478	8	A	G	G	11	11	PLEC	G	4	4
WHSC1L1	54904	broad.mit.edu	36	8	38267226	38267226	+	Silent	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:38267226G>A	uc003xli.1	-	c.3042C>T	c.(3040-3042)GGC>GGT	p.G1014G	WHSC1L1_uc010lwe.1_Silent_p.G965G	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	1014	PWWP 2.				cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|zinc ion binding				0	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)								521				0.264151	213.08504	231.753313	98	273	GG		KEEP	---	---	---	---	capture	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)		Silent	SNP	38267226	38267226	17937	8	G	A	A	46	46	WHSC1L1	A	2	2
JPH1	56704	broad.mit.edu	36	8	75334249	75334249	+	Missense_Mutation	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:75334249C>T	uc003yae.1	-	c.1183G>A	c.(1183-1185)GCG>ACG	p.A395T	JPH1_uc003yaf.2_Missense_Mutation_p.A395T|JPH1_uc003yag.1_Missense_Mutation_p.A259T	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	395	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)													0.377049	65.415142	66.222387	23	38	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)		Missense_Mutation	SNP	75334249	75334249	8264	8	C	T	T	27	27	JPH1	T	1	1
RALYL	138046	broad.mit.edu	36	8	85937101	85937101	+	Silent	SNP	C	T	T			TCGA-27-2518-01	TCGA-27-2518-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:85937101C>T	uc003yct.2	+	c.468C>T	c.(466-468)CAC>CAT	p.H156H	RALYL_uc003ycq.2_Silent_p.H143H|RALYL_uc003ycr.2_Silent_p.H143H|RALYL_uc003ycs.2_Silent_p.H143H|RALYL_uc010lzy.1_Silent_p.H132H|RALYL_uc003ycu.2_Silent_p.H70H|RALYL_uc003ycv.2_Silent_p.H55H	NM_001100391	NP_001093861	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 1	143							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1														0.131579	7.253073	12.262298	5	33	CC		KEEP	---	---	---	---	capture			Silent	SNP	85937101	85937101	13480	8	C	T	T	19	19	RALYL	T	1	1
ROR2	4920	broad.mit.edu	36	9	93535491	93535491	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:93535491G>A	uc004arj.1	-	c.671C>T	c.(670-672)TCA>TTA	p.S224L	ROR2_uc004ari.1_Missense_Mutation_p.S84L|ROR2_uc004ark.2_Missense_Mutation_p.S224L	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	224	FZ.|Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(6)|central_nervous_system(5)|ovary(3)|large_intestine(2)	16										461				0.3	23.288745	24.346613	9	21	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	93535491	93535491	14006	9	G	A	A	45	45	ROR2	A	2	2
CORO2A	7464	broad.mit.edu	36	9	99936949	99936949	+	Missense_Mutation	SNP	G	A	A			TCGA-27-2518-01	TCGA-27-2518-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:99936949G>A	uc004ayl.1	-	c.428C>T	c.(427-429)ACG>ATG	p.T143M	CORO2A_uc004aym.1_Missense_Mutation_p.T143M	NM_003389	NP_438171	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	143	WD 2.				actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			ovary(1)|pancreas(1)	2		Acute lymphoblastic leukemia(62;0.0559)												0.290323	20.504989	21.702916	9	22	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	99936949	99936949	3894	9	G	A	A	40	40	CORO2A	A	1	1
KCNN2	3781	broad.mit.edu	36	5	113726530	113726531	+	In_Frame_Ins	INS	-	GCC	GCC			TCGA-27-2518-01	TCGA-27-2518-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:113726530_113726531insGCC	uc003kqo.1	+	c.159_160insGCC	c.(157-162)insGCC	p.58_59insA		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	58_59						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)										0.43			3	4				---	---	---	---	capture_indel			In_Frame_Ins	INS	113726530	113726531	8384	5	-	GCC	GCC	55	55	KCNN2	GCC	5	5
