Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
KIRREL3	84623	broad.mit.edu	36	11	125848500	125848500	+	Missense_Mutation	SNP	T	G	G			TCGA-28-5215-01	TCGA-28-5215-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:125848500T>G	uc001qea.1	-	c.505A>C	c.(505-507)ACC>CCC	p.T169P	KIRREL3_uc001qeb.1_Missense_Mutation_p.T169P|KIRREL3_uc001qec.1_Missense_Mutation_p.T169P	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3	169	Ig-like C2-type 2.|Extracellular (Potential).				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)												0.428571	8.725122	8.808319	6	8	TT		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)	Missense_Mutation	SNP	125848500	125848500	8638	11	T	G	G	59	59	KIRREL3	G	4	4
OR5D16	390144	broad.mit.edu	36	11	55363353	55363353	+	Missense_Mutation	SNP	T	C	C			TCGA-28-5215-01	TCGA-28-5215-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:55363353T>C	uc001nhz.1	+	c.550T>C	c.(550-552)TCC>CCC	p.S184P		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3		all_epithelial(135;0.208)												0.321586	233.222539	239.625475	73	154	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55363353	55363353	11566	11	T	C	C	50	50	OR5D16	C	4	4
DCHS1	8642	broad.mit.edu	36	11	6610384	6610384	+	Missense_Mutation	SNP	T	G	G			TCGA-28-5215-01	TCGA-28-5215-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:6610384T>G	uc001mem.1	-	c.2935A>C	c.(2935-2937)ACC>CCC	p.T979P		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	979	Cadherin 9.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)												0.375	6.620759	6.731156	3	5	TT		KEEP	---	---	---	---	capture		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Missense_Mutation	SNP	6610384	6610384	4458	11	T	G	G	59	59	DCHS1	G	4	4
PITPNM1	9600	broad.mit.edu	36	11	67022304	67022304	+	Missense_Mutation	SNP	G	C	C			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:67022304G>C	uc001olx.1	-	c.1550C>G	c.(1549-1551)GCC>GGC	p.A517G	PITPNM1_uc001olw.1_5'UTR|PITPNM1_uc001oly.1_Missense_Mutation_p.A517G|PITPNM1_uc001olz.1_Missense_Mutation_p.A517G	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	517					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						GBM(28;144 709 4607 5525)								0.2	7.162598	9.26187	5	20	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	67022304	67022304	12374	11	G	C	C	42	42	PITPNM1	C	3	3
PNPLA2	57104	broad.mit.edu	36	11	814015	814015	+	Missense_Mutation	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:814015G>A	uc001lrt.1	+	c.937G>A	c.(937-939)GTG>ATG	p.V313M	PNPLA2_uc009ycl.1_Missense_Mutation_p.R124H	NM_020376	NP_065109	Q96AD5	PLPL2_HUMAN	patatin-like phospholipase domain containing 2	313	Lumenal (Potential).				negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process	integral to membrane|lipid particle|plasma membrane	triglyceride lipase activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)												0.37931	26.614863	26.986392	11	18	GG		KEEP	---	---	---	---	capture		all cancers(45;1.63e-25)|Epithelial(43;1.28e-24)|OV - Ovarian serous cystadenocarcinoma(40;7.09e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Missense_Mutation	SNP	814015	814015	12592	11	G	A	A	40	40	PNPLA2	A	1	1
TMEM132D	121256	broad.mit.edu	36	12	128260114	128260114	+	Silent	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:128260114G>A	uc009zyl.1	-	c.1347C>T	c.(1345-1347)GCC>GCT	p.A449A		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D	449	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)	12	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)												0.179245	31.561568	41.827735	19	87	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)	Silent	SNP	128260114	128260114	16579	12	G	A	A	39	39	TMEM132D	A	1	1
RACGAP1	29127	broad.mit.edu	36	12	48674209	48674209	+	Silent	SNP	G	C	C			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:48674209G>C	uc001rvt.2	-	c.1311C>G	c.(1309-1311)CGC>CGG	p.R437R	RACGAP1_uc009zlm.1_Silent_p.R437R|RACGAP1_uc001rvs.2_Silent_p.R437R|RACGAP1_uc001rvu.2_Silent_p.R437R	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	437	Rho-GAP.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1														0.388112	376.173593	379.306255	111	175	GG		KEEP	---	---	---	---	capture			Silent	SNP	48674209	48674209	13436	12	G	C	C	42	42	RACGAP1	C	3	3
LRP1	4035	broad.mit.edu	36	12	55857637	55857637	+	Missense_Mutation	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:55857637G>A	uc001snd.1	+	c.4357G>A	c.(4357-4359)GCC>ACC	p.A1453T		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1453	Extracellular (Potential).|LDL-receptor class B 11.				apoptotic cell clearance|multicellular organismal development|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein particle receptor binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(7)|large_intestine(2)|pancreas(2)|skin(1)|central_nervous_system(1)	13					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)					1456				0.365079	51.388576	52.404557	23	40	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(357;0.0103)	Missense_Mutation	SNP	55857637	55857637	9324	12	G	A	A	38	38	LRP1	A	1	1
OR6S1	341799	broad.mit.edu	36	14	20179649	20179649	+	Silent	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:20179649G>A	uc001vxv.1	-	c.42C>T	c.(40-42)TTC>TTT	p.F14F		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00304)													0.642857	464.073064	468.594166	162	90	GG		KEEP	---	---	---	---	capture	Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)	Silent	SNP	20179649	20179649	11620	14	G	A	A	37	37	OR6S1	A	1	1
SLC30A4	7782	broad.mit.edu	36	15	43601819	43601819	+	Missense_Mutation	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:43601819C>T	uc001zvj.1	-	c.26G>A	c.(25-27)CGC>CAC	p.R9H	C15orf21_uc010beg.1_Intron|C15orf21_uc010beh.1_Intron|C15orf21_uc010bei.1_Intron|C15orf21_uc010bej.1_Intron|C15orf21_uc001zvm.1_Intron|C15orf21_uc001zvn.1_Intron	NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	9	Cytoplasmic (Potential).				regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)								11				0.215686	19.004249	22.806726	11	40	CC		KEEP	---	---	---	---	capture		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)	Missense_Mutation	SNP	43601819	43601819	15054	15	C	T	T	27	27	SLC30A4	T	1	1
SHCBP1	79801	broad.mit.edu	36	16	45173250	45173250	+	Silent	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:45173250C>T	uc002eec.2	-	c.1911G>A	c.(1909-1911)GGG>GGA	p.G637G		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	637										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)												0.427509	326.693684	327.922769	115	154	CC		KEEP	---	---	---	---	capture			Silent	SNP	45173250	45173250	14766	16	C	T	T	30	30	SHCBP1	T	2	2
MYH2	4620	broad.mit.edu	36	17	10373447	10373447	+	Nonsense_Mutation	SNP	A	T	T			TCGA-28-5215-01	TCGA-28-5215-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr17:10373447A>T	uc010coi.1	-	c.3194T>A	c.(3193-3195)TTG>TAG	p.L1065*	MYH2_uc002gmp.2_Nonsense_Mutation_p.L1065*|MYH2_uc010coj.1_Intron	NM_001100112	NP_060004	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1065	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|lung(1)|kidney(1)	11														0.65035	277.988864	280.839542	93	50	AA		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	10373447	10373447	10430	17	A	T	T	5	5	MYH2	T	5	4
TLCD1	116238	broad.mit.edu	36	17	24076484	24076484	+	Missense_Mutation	SNP	G	C	C			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:24076484G>C	uc002hco.1	-	c.325C>G	c.(325-327)CGA>GGA	p.R109G		NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1	109	TLC.					integral to membrane					0	Lung NSC(42;0.00431)													0.239437	12.576458	17.254039	17	54	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	24076484	24076484	16466	17	G	C	C	38	38	TLCD1	C	3	3
KRT17	3872	broad.mit.edu	36	17	37034007	37034007	+	Missense_Mutation	SNP	C	T	T	rs28928897	unknown	TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:37034007C>T	uc002hxh.1	-	c.281G>A	c.(280-282)CGC>CAC	p.R94H		NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	94	Coil 1A.|Rod.		R -> H (in SM).|R -> C (in PC2 and SM).|Missing (in PC2).|R -> P (in PC2).	Missing (in Ref. 5; AAH72018).	epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				Pancreas(92;1242 2086 39193 50508)								0.332248	232.513983	240.183838	102	205	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	37034007	37034007	8769	17	C	T	T	27	27	KRT17	T	1	1
CCDC45	90799	broad.mit.edu	36	17	59949431	59949431	+	Missense_Mutation	SNP	T	C	C			TCGA-28-5215-01	TCGA-28-5215-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr17:59949431T>C	uc002jem.1	+	c.865T>C	c.(865-867)TCC>CCC	p.S289P	CCDC45_uc002jen.1_Non-coding_Transcript	NM_138363	NP_612372	Q96GE4	CCD45_HUMAN	coiled-coil domain containing 45	289							protein binding			ovary(1)	1	Breast(5;1.32e-14)													0.25	6.513264	8.210037	7	21	TT		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(8;8.6e-12)		Missense_Mutation	SNP	59949431	59949431	2939	17	T	C	C	54	54	CCDC45	C	4	4
HELZ	9931	broad.mit.edu	36	17	62587509	62587509	+	Missense_Mutation	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:62587509C>T	uc002jfx.2	-	c.2041G>A	c.(2041-2043)GCT>ACT	p.A681T	HELZ_uc002jfv.2_Non-coding_Transcript	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)													0.349515	90.370036	92.427439	36	67	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	62587509	62587509	7332	17	C	T	T	26	26	HELZ	T	2	2
TP53	7157	broad.mit.edu	36	17	7520037	7520037	+	Silent	SNP	C	T	T	rs68140816	unknown	TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:7520037C>T	uc002gim.2	-	c.375G>A	c.(373-375)ACG>ACA	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.1_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.T125T(14)|p.0?(6)|p.V73fs*9(1)|p.?(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)				Pancreas(47;798 1329 9957 10801)		111	p.T125T(SNU899-Tumor)	690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.555556	130.573423	130.790292	45	36	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)	Silent	SNP	7520037	7520037	16923	17	C	T	T	23	23	TP53	T	1	1
EPB41L3	23136	broad.mit.edu	36	18	5424010	5424010	+	Missense_Mutation	SNP	T	C	C			TCGA-28-5215-01	TCGA-28-5215-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr18:5424010T>C	uc002kmt.1	-	c.716A>G	c.(715-717)GAC>GGC	p.D239G	EPB41L3_uc002kmu.1_Missense_Mutation_p.D239G|EPB41L3_uc010dkq.1_Missense_Mutation_p.D130G|EPB41L3_uc010dks.1_Missense_Mutation_p.D261G|EPB41L3_uc002kmv.1_Missense_Mutation_p.D130G	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	239	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5														0.326347	353.312199	362.274584	109	225	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	5424010	5424010	5347	18	T	C	C	58	58	EPB41L3	C	4	4
BCAR3	8412	broad.mit.edu	36	1	93805552	93805552	+	Missense_Mutation	SNP	A	G	G			TCGA-28-5215-01	TCGA-28-5215-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr1:93805552A>G	uc001dpz.1	-	c.2171T>C	c.(2170-2172)TTT>TCT	p.F724S	BCAR3_uc001dpy.1_Missense_Mutation_p.F633S|BCAR3_uc001dqa.1_Missense_Mutation_p.F724S|BCAR3_uc001dqb.1_Missense_Mutation_p.F724S|BCAR3_uc001dpx.2_Missense_Mutation_p.F400S	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	724	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)												0.407895	207.129255	208.25373	62	90	AA		KEEP	---	---	---	---	capture		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)	Missense_Mutation	SNP	93805552	93805552	1370	1	A	G	G	1	1	BCAR3	G	4	4
CABIN1	23523	broad.mit.edu	36	22	22782748	22782748	+	Missense_Mutation	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:22782748G>A	uc002zzi.1	+	c.1187G>A	c.(1186-1188)CGT>CAT	p.R396H	CABIN1_uc002zzj.1_Missense_Mutation_p.R346H|CABIN1_uc002zzl.1_Missense_Mutation_p.R396H|CABIN1_uc010guk.1_Missense_Mutation_p.R351H|CABIN1_uc002zzk.1_Missense_Mutation_p.R351H	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	396					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4														0.333333	203.923747	210.867671	93	186	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	22782748	22782748	2644	22	G	A	A	40	40	CABIN1	A	1	1
ST6GAL2	84620	broad.mit.edu	36	2	106826093	106826093	+	Missense_Mutation	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:106826093C>T	uc002tdr.1	-	c.773G>A	c.(772-774)CGC>CAC	p.R258H	ST6GAL2_uc002tds.2_Missense_Mutation_p.R258H	NM_032528	NP_115917	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	258	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(3)	9														0.5	10.198262	10.198262	4	4	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	106826093	106826093	15740	2	C	T	T	27	27	ST6GAL2	T	1	1
PSD4	23550	broad.mit.edu	36	2	113666589	113666589	+	Missense_Mutation	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:113666589G>A	uc002tjc.1	+	c.1790G>A	c.(1789-1791)CGC>CAC	p.R597H	PSD4_uc002tjd.1_Missense_Mutation_p.R218H|PSD4_uc002tje.1_Missense_Mutation_p.R568H|PSD4_uc002tjf.1_Missense_Mutation_p.R218H	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	597	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2														0.378788	117.694471	119.403495	50	82	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	113666589	113666589	13102	2	G	A	A	38	38	PSD4	A	1	1
INPP5D	3635	broad.mit.edu	36	2	233777543	233777543	+	Missense_Mutation	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:233777543C>T	uc002vtv.1	+	c.3008C>T	c.(3007-3009)ACG>ATG	p.T1003M	INPP5D_uc002vtw.1_Missense_Mutation_p.T1002M	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	1003	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)				NSCLC(82;1215 1426 16163 20348 41018)				816				0.333333	11.468119	11.838069	5	10	CC		KEEP	---	---	---	---	capture		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)	Missense_Mutation	SNP	233777543	233777543	8057	2	C	T	T	19	19	INPP5D	T	1	1
VHL	7428	broad.mit.edu	36	3	10158661	10158661	+	Missense_Mutation	SNP	G	T	T			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:10158661G>T	uc003bvc.1	+	c.130G>T	c.(130-132)GGC>TGC	p.G44C	VHL_uc003bvd.1_Missense_Mutation_p.G44C	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	44	7.|8 X 5 AA tandem repeats of G-[PAVG]-E-E- [DAYSLE].				anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding			kidney(1268)|soft_tissue(24)|adrenal_gland(14)|large_intestine(13)|pancreas(5)|endometrium(4)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|thyroid(1)|pleura(1)|paratesticular_tissues(1)	1338								1		45				0.375	8.624226	8.73348	3	5	GG		KEEP	---	---	---	---	capture		Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)	Missense_Mutation	SNP	10158661	10158661	17729	3	G	T	T	39	39	VHL	T	3	3
SI	6476	broad.mit.edu	36	3	166215695	166215695	+	Silent	SNP	A	G	G			TCGA-28-5215-01	TCGA-28-5215-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr3:166215695A>G	uc003fei.1	-	c.3909T>C	c.(3907-3909)AAT>AAC	p.N1303N		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1303	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|pancreas(1)	8		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)									0.445378	178.174506	178.481234	53	66	AA		KEEP	---	---	---	---	capture			Silent	SNP	166215695	166215695	14792	3	A	G	G	8	8	SI	G	4	4
TRIM71	131405	broad.mit.edu	36	3	32908306	32908306	+	Silent	SNP	A	G	G			TCGA-28-5215-01	TCGA-28-5215-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr3:32908306A>G	uc003cff.1	+	c.2606A>G	c.(2605-2607)TAA>TGA	p.*869*		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	869					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3														0.316	252.064495	259.576324	79	171	AA		KEEP	---	---	---	---	capture			Silent	SNP	32908306	32908306	17093	3	A	G	G	13	13	TRIM71	G	4	4
TRIML2	205860	broad.mit.edu	36	4	189249724	189249724	+	Missense_Mutation	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:189249724C>T	uc003izl.1	-	c.961G>A	c.(961-963)GGG>AGG	p.G321R	TRIML2_uc003izj.1_Missense_Mutation_p.G149S|TRIML2_uc003izk.1_Missense_Mutation_p.G129S	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	321	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)												0.30914	298.172601	310.25646	115	257	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)	Missense_Mutation	SNP	189249724	189249724	17101	4	C	T	T	21	21	TRIML2	T	2	2
SIM1	6492	broad.mit.edu	36	6	101018039	101018039	+	Silent	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:101018039C>T	uc003pqj.2	-	c.27G>A	c.(25-27)GCG>GCA	p.A9A	SIM1_uc010kct.1_Silent_p.A9A|SIM1_uc010kcu.1_Silent_p.A9A	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	9	Basic motif.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)												0.363855	367.372795	374.154542	151	264	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(108;0.0774)	Silent	SNP	101018039	101018039	14818	6	C	T	T	27	27	SIM1	T	1	1
FNDC1	84624	broad.mit.edu	36	6	159575371	159575371	+	Silent	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:159575371G>A	uc010kjv.1	+	c.3837G>A	c.(3835-3837)CCG>CCA	p.P1279P	FNDC1_uc010kjw.1_Silent_p.P1164P	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1279						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)												0.5	27.419475	27.419475	11	11	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)	Silent	SNP	159575371	159575371	6210	6	G	A	A	38	38	FNDC1	A	1	1
CHN2	1124	broad.mit.edu	36	7	29404574	29404574	+	Silent	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:29404574C>T	uc003szz.1	+	c.237C>T	c.(235-237)GCC>GCT	p.A79A	CHN2_uc010kva.1_Intron|CHN2_uc010kvb.1_Intron|CHN2_uc010kvc.1_Silent_p.A44A|CHN2_uc010kvd.1_Intron	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	79	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						Ovarian(1;44 48 13232 18918 31480)								0.33631	324.866804	332.833511	113	223	CC		KEEP	---	---	---	---	capture			Silent	SNP	29404574	29404574	3497	7	C	T	T	24	24	CHN2	T	2	2
ASB4	51666	broad.mit.edu	36	7	94953294	94953294	+	Silent	SNP	A	G	G			TCGA-28-5215-01	TCGA-28-5215-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:94953294A>G	uc003uny.1	+	c.75A>G	c.(73-75)CTA>CTG	p.L25L	ASB4_uc003unx.1_Silent_p.L25L	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	25					intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)													0.4	211.894644	213.198791	60	90	AA		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.0151)		Silent	SNP	94953294	94953294	1043	7	A	G	G	13	13	ASB4	G	4	4
ANK1	286	broad.mit.edu	36	8	41685626	41685626	+	Missense_Mutation	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:41685626C>T	uc003xom.1	-	c.1924G>A	c.(1924-1926)GCT>ACT	p.A642T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.1_5'Flank|ANK1_uc003xoi.1_Missense_Mutation_p.A609T|ANK1_uc003xoj.1_Missense_Mutation_p.A609T|ANK1_uc003xok.1_Missense_Mutation_p.A609T|ANK1_uc003xol.1_Missense_Mutation_p.A609T	NM_020475	NP_065208	P16157	ANK1_HUMAN	ankyrin 1 isoform 4	609	ANK 18.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)|breast(1)	8	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)												0.282258	70.356659	75.653134	35	89	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)		Missense_Mutation	SNP	41685626	41685626	623	8	C	T	T	27	27	ANK1	T	1	1
ATP6V0D2	245972	broad.mit.edu	36	8	87231472	87231472	+	Missense_Mutation	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:87231472C>T	uc003ydp.1	+	c.655C>T	c.(655-657)CGT>TGT	p.R219C		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	219					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0														0.215434	125.447066	148.708364	67	244	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	87231472	87231472	1193	8	C	T	T	19	19	ATP6V0D2	T	1	1
ADAMTSL1	92949	broad.mit.edu	36	9	18767555	18767555	+	Missense_Mutation	SNP	C	T	T			TCGA-28-5215-01	TCGA-28-5215-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:18767555C>T	uc003zne.2	+	c.3328C>T	c.(3328-3330)CGC>TGC	p.R1110C		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1110						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|lung(1)	4														0.28125	21.459196	22.837136	9	23	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(50;1.29e-17)	Missense_Mutation	SNP	18767555	18767555	275	9	C	T	T	23	23	ADAMTSL1	T	1	1
DCX	1641	broad.mit.edu	36	X	110531205	110531205	+	Missense_Mutation	SNP	T	G	G			TCGA-28-5215-01	TCGA-28-5215-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chrX:110531205T>G	uc004epd.1	-	c.617A>C	c.(616-618)TAT>TCT	p.Y206S	DCX_uc004epe.1_Missense_Mutation_p.Y125S|DCX_uc004epf.1_Missense_Mutation_p.Y125S|DCX_uc004epg.1_Missense_Mutation_p.Y125S	NM_000555	NP_835366	O43602	DCX_HUMAN	doublecortin isoform a	206	Doublecortin 1.		Y -> H (in LISX1 and SBHX).|Y -> D (in SBHX).		axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4														0.345992	262.610726	267.558803	82	155	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	110531205	110531205	4489	23	T	G	G	49	49	DCX	G	4	4
ATP6AP1	537	broad.mit.edu	36	X	153316902	153316902	+	Missense_Mutation	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:153316902G>A	uc004flf.1	+	c.1060G>A	c.(1060-1062)GCC>ACC	p.A354T	ATP6AP1_uc004flg.1_Non-coding_Transcript|ATP6AP1_uc004flh.1_Missense_Mutation_p.A314T|GDI1_uc004fli.2_5'Flank	NM_001183	NP_001174	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory	354					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(3)|breast(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)													0.294643	68.224034	72.456889	33	79	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	153316902	153316902	1184	23	G	A	A	38	38	ATP6AP1	A	1	1
YY2	404281	broad.mit.edu	36	X	21785307	21785307	+	Missense_Mutation	SNP	G	A	A			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:21785307G>A	uc010nfq.1	+	c.1438G>A	c.(1438-1440)GAA>AAA	p.E480K	MBTPS2_uc004dab.1_Intron|MBTPS2_uc004dac.1_Intron|MBTPS2_uc010nfr.1_Intron|YY2_uc004dad.1_Missense_Mutation_p.E262K	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	262	Mediates transcriptional repression.|C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2														0.332512	287.353692	297.461451	135	271	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	21785307	21785307	18092	23	G	A	A	37	37	YY2	A	1	1
ZNF630	57232	broad.mit.edu	36	X	47803875	47803875	+	Missense_Mutation	SNP	G	C	C			TCGA-28-5215-01	TCGA-28-5215-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:47803875G>C	uc004div.2	-	c.900C>G	c.(898-900)TTC>TTG	p.F300L	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.1_Missense_Mutation_p.F176L|ZNF630_uc010nia.1_Missense_Mutation_p.F176L	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	300	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2														0.30303	225.068898	233.064029	70	161	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	47803875	47803875	18649	23	G	C	C	45	45	ZNF630	C	3	3
KCNN2	3781	broad.mit.edu	36	5	113726530	113726531	+	In_Frame_Ins	INS	-	GCC	GCC			TCGA-28-5215-01	TCGA-28-5215-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:113726530_113726531insGCC	uc003kqo.1	+	c.159_160insGCC	c.(157-162)insGCC	p.58_59insA		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	58_59						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)										0.50			3	3				---	---	---	---	capture_indel			In_Frame_Ins	INS	113726530	113726531	8384	5	-	GCC	GCC	55	55	KCNN2	GCC	5	5
