Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
PAX2	5076	broad.mit.edu	36	10	102500615	102500615	+	Silent	SNP	G	C	C			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:102500615G>C	uc001krk.2	+	c.387G>C	c.(385-387)GTG>GTC	p.V129V	PAX2_uc001krm.2_Silent_p.V129V|PAX2_uc001krl.2_Silent_p.V129V|PAX2_uc001krn.2_Silent_p.V129V|PAX2_uc001kro.2_Silent_p.V129V|PAX2_uc001krp.1_Silent_p.V133V	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	129	Paired.				anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve formation|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter development|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|promoter binding|superoxide-generating NADPH oxidase activity|transcription activator activity|transcription repressor activity				0		Colorectal(252;0.234)												0.171429	7.111355	10.724931	6	29	GG		KEEP	---	---	---	---	capture		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)	Silent	SNP	102500615	102500615	11899	10	G	C	C	46	46	PAX2	C	3	3
NFKB2	4791	broad.mit.edu	36	10	104148511	104148511	+	Silent	SNP	G	T	T			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:104148511G>T	uc001kvb.1	+	c.1017G>T	c.(1015-1017)CGG>CGT	p.R339R	NFKB2_uc001kva.1_Silent_p.R339R|NFKB2_uc001kvc.2_Silent_p.R339R|NFKB2_uc001kvd.1_Silent_p.R339R|NFKB2_uc009xxc.1_Silent_p.R339R	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	339	RHD.|Nuclear localization signal (Potential).				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0		Colorectal(252;0.00957)								140				0.653846	52.785566	53.332697	17	9	GG		KEEP	---	---	---	---	capture		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)	Silent	SNP	104148511	104148511	10776	10	G	T	T	41	41	NFKB2	T	3	3
PTEN	5728	broad.mit.edu	36	10	89682815	89682815	+	Missense_Mutation	SNP	G	T	T	rs57374291	unknown	TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:89682815G>T	uc001kfb.1	+	c.319G>T	c.(319-321)GAT>TAT	p.D107Y		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	107	Phosphatase tensin-type.		D -> Y (in BZS and glioblastoma; loss of phosphatase activity towards Ins(1,3,4,5)P4).		apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of focal adhesion assembly|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of cyclin-dependent protein kinase activity|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.D107Y(3)|p.Y27_N212>Y(2)|p.F56fs*2(1)|p.P103fs*3(1)|p.D107N(1)		endometrium(831)|central_nervous_system(654)|skin(119)|haematopoietic_and_lymphoid_tissue(101)|prostate(97)|large_intestine(90)|breast(67)|lung(63)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(21)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(12)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2308		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)						31		264	TCGA GBM(2;<1E-8)|TSP Lung(26;0.18)			0.677778	195.29931	197.822333	61	29	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)	Missense_Mutation	SNP	89682815	89682815	13192	10	G	T	T	33	33	PTEN	T	3	3
SLIT1	6585	broad.mit.edu	36	10	98768788	98768788	+	Missense_Mutation	SNP	C	G	G			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:98768788C>G	uc001kmw.2	-	c.2813G>C	c.(2812-2814)GGC>GCC	p.G938A		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1	938	EGF-like 1.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)												0.333333	10.496018	10.791217	4	8	CC		KEEP	---	---	---	---	capture		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)	Missense_Mutation	SNP	98768788	98768788	15237	10	C	G	G	26	26	SLIT1	G	3	3
SIK2	23235	broad.mit.edu	36	11	111095802	111095802	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:111095802G>A	uc001plt.1	+	c.1360G>A	c.(1360-1362)GAA>AAA	p.E454K		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	454					intracellular protein kinase cascade|protein phosphorylation|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)	2										204				0.418605	109.387044	109.883834	36	50	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	111095802	111095802	14813	11	G	A	A	37	37	SIK2	A	1	1
OR51L1	119682	broad.mit.edu	36	11	4977331	4977331	+	Silent	SNP	T	C	C			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:4977331T>C	uc001lzw.1	+	c.543T>C	c.(541-543)TGT>TGC	p.C181C		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)												0.354369	241.723927	245.571199	73	133	TT		KEEP	---	---	---	---	capture		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)	Silent	SNP	4977331	4977331	11512	11	T	C	C	60	60	OR51L1	C	4	4
OR4D6	219983	broad.mit.edu	36	11	58981732	58981732	+	Silent	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:58981732G>A	uc001nny.1	+	c.723G>A	c.(721-723)ACG>ACA	p.T241T		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1														0.397727	203.117861	204.726676	70	106	GG		KEEP	---	---	---	---	capture			Silent	SNP	58981732	58981732	11465	11	G	A	A	40	40	OR4D6	A	1	1
CHRDL2	25884	broad.mit.edu	36	11	74092171	74092171	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:74092171G>A	uc001ovh.1	-	c.773C>T	c.(772-774)ACG>ATG	p.T258M	CHRDL2_uc001ovg.1_Missense_Mutation_p.T142M|CHRDL2_uc001ovi.1_Missense_Mutation_p.T258M|CHRDL2_uc001ovj.1_Non-coding_Transcript|CHRDL2_uc001ovk.1_Intron	NM_015424	NP_056239	Q6WN34	CRDL2_HUMAN	chordin-like 2	258	VWFC 3.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)													0.566667	50.175269	50.2911	17	13	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	74092171	74092171	3508	11	G	A	A	40	40	CHRDL2	A	1	1
HCFC2	29915	broad.mit.edu	36	12	102985947	102985947	+	Silent	SNP	T	C	C			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr12:102985947T>C	uc001tkj.2	+	c.405T>C	c.(403-405)TAT>TAC	p.Y135Y	HCFC2_uc009zul.1_Non-coding_Transcript	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	135					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						Esophageal Squamous(184;1814 2036 4771 6974 15702)								0.436508	483.213848	484.542321	165	213	TT		KEEP	---	---	---	---	capture			Silent	SNP	102985947	102985947	7275	12	T	C	C	51	51	HCFC2	C	4	4
ANO2	57101	broad.mit.edu	36	12	5542956	5542956	+	Missense_Mutation	SNP	T	A	A			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr12:5542956T>A	uc001qnm.1	-	c.2770A>T	c.(2770-2772)ATT>TTT	p.I924F		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	928	Helical; (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7														0.442105	133.439211	133.716182	42	53	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	5542956	5542956	705	12	T	A	A	50	50	ANO2	A	4	4
PLEKHG6	55200	broad.mit.edu	36	12	6306937	6306937	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:6306937C>T	uc001qnr.1	+	c.1927C>T	c.(1927-1929)CGC>TGC	p.R643C		NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	643					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1														0.478261	68.448451	68.467269	22	24	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	6306937	6306937	12500	12	C	T	T	19	19	PLEKHG6	T	1	1
RB1	5925	broad.mit.edu	36	13	47937231	47937231	+	Nonsense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr13:47937231C>T	uc001vcb.1	+	c.2308C>T	c.(2308-2310)CAG>TAG	p.Q770*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	770	Interaction with LIMD1.|Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|transcription repressor activity|ubiquitin protein ligase binding	p.L769fs*2(1)|p.?(1)		lung(93)|eye(89)|central_nervous_system(47)|bone(22)|breast(20)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|soft_tissue(8)|prostate(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	355		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)			Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)			6		568	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0.818182	144.903204	150.131888	45	10	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Nonsense_Mutation	SNP	47937231	47937231	13559	13	C	T	T	25	25	RB1	T	5	2
TM9SF1	10548	broad.mit.edu	36	14	23731389	23731389	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr14:23731389C>T	uc001wnb.1	-	c.981G>A	c.(979-981)ATG>ATA	p.M327I	IPO4_uc001wmw.1_5'Flank|IPO4_uc001wmx.1_5'Flank|IPO4_uc001wmy.1_5'Flank|IPO4_uc001wmz.1_5'Flank|TM9SF1_uc001wna.1_Non-coding_Transcript|TM9SF1_uc001wnc.1_Missense_Mutation_p.M327I|TM9SF1_uc001wnd.1_Missense_Mutation_p.M183I	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	327	Helical; (Potential).				autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1														0.258065	19.583851	21.22933	8	23	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(265;0.0183)	Missense_Mutation	SNP	23731389	23731389	16507	14	C	T	T	21	21	TM9SF1	T	2	2
SERPINA4	5267	broad.mit.edu	36	14	94103277	94103277	+	Silent	SNP	T	A	A			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr14:94103277T>A	uc010avd.1	+	c.978T>A	c.(976-978)ATT>ATA	p.I326I	SERPINA4_uc001ydk.1_Silent_p.I289I|SERPINA4_uc001ydl.1_Silent_p.I289I	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	289					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)	3														0.350515	98.421241	100.333256	34	63	TT		KEEP	---	---	---	---	capture		COAD - Colon adenocarcinoma(157;0.211)	Silent	SNP	94103277	94103277	14579	14	T	A	A	63	63	SERPINA4	A	4	4
MAP1A	4130	broad.mit.edu	36	15	41605076	41605076	+	Silent	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:41605076C>T	uc001zrt.1	+	c.4113C>T	c.(4111-4113)GAC>GAT	p.D1371D		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1371						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)	8		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)			Estramustine(DB01196)									0.418605	102.380126	102.878517	36	50	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(94;3.05e-06)	Silent	SNP	41605076	41605076	9610	15	C	T	T	17	17	MAP1A	T	2	2
CSPG4	1464	broad.mit.edu	36	15	73769384	73769384	+	Missense_Mutation	SNP	A	T	T			TCGA-32-2634-01	TCGA-32-2634-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr15:73769384A>T	uc002baw.1	-	c.1077T>A	c.(1075-1077)AGT>AGA	p.S359R		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	359	Extracellular (Potential).|Neurite growth inhibition (By similarity).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3										549				0.16	7.184121	9.93638	4	21	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	73769384	73769384	4101	15	A	T	T	6	6	CSPG4	T	4	4
HYDIN	54768	broad.mit.edu	36	16	69446665	69446665	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:69446665C>T	uc002ezr.1	-	c.12307G>A	c.(12307-12309)GAG>AAG	p.E4103K	HYDIN_uc010cfy.1_Non-coding_Transcript	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4104										ovary(1)	1		Ovarian(137;0.0654)												0.211321	128.049404	148.475694	56	209	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	69446665	69446665	7767	16	C	T	T	30	30	HYDIN	T	2	2
DHRS11	79154	broad.mit.edu	36	17	32025620	32025620	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:32025620G>A	uc002hnd.1	+	c.254G>A	c.(253-255)CGT>CAT	p.R85H		NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase	85					oxidation-reduction process	extracellular region	binding|oxidoreductase activity				0														0.880503	473.728317	496.432947	140	19	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	32025620	32025620	4666	17	G	A	A	40	40	DHRS11	A	1	1
LAMA3	3909	broad.mit.edu	36	18	19765112	19765112	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr18:19765112C>T	uc002kuq.1	+	c.8525C>T	c.(8524-8526)ACG>ATG	p.T2842M	LAMA3_uc002kur.1_Missense_Mutation_p.T2786M|LAMA3_uc002kus.2_Missense_Mutation_p.T1233M|LAMA3_uc002kut.2_Missense_Mutation_p.T1177M	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2842	Laminin G-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|central_nervous_system(1)	9	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)									0.763889	182.442992	187.024076	55	17	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	19765112	19765112	8930	18	C	T	T	19	19	LAMA3	T	1	1
CACNA1A	773	broad.mit.edu	36	19	13216996	13216996	+	Silent	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:13216996C>T	uc010dzd.1	-	c.4962G>A	c.(4960-4962)GGG>GGA	p.G1654G	CACNA1A_uc002mwx.2_Silent_p.G356G|CACNA1A_uc010dzc.1_Silent_p.G1176G|CACNA1A_uc002mwz.2_Silent_p.G1654G|CACNA1A_uc002mwy.2_Silent_p.G1650G|CACNA1A_uc010dze.1_Silent_p.G1651G|CACNA1A_uc002mwv.2_Silent_p.G167G	NM_023035	NP_075461	O00555	CAC1A_HUMAN	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).	1651	Extracellular (Potential).|IV.			G -> GNP (in Ref. 1; AAB61613/AAB61612).	cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2					Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)									0.327273	54.229447	55.685638	18	37	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Silent	SNP	13216996	13216996	2654	19	C	T	T	22	22	CACNA1A	T	2	2
GNA15	2769	broad.mit.edu	36	19	3102776	3102776	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:3102776G>A	uc002lxf.2	+	c.557G>A	c.(556-558)CGC>CAC	p.R186H		NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	186					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity				0		Hepatocellular(1079;0.137)												0.442396	273.56127	274.18947	96	121	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)	Missense_Mutation	SNP	3102776	3102776	6772	19	G	A	A	38	38	GNA15	A	1	1
ATP4A	495	broad.mit.edu	36	19	40743256	40743256	+	Silent	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:40743256G>A	uc002oal.1	-	c.636C>T	c.(634-636)GCC>GCT	p.A212A	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	212	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)				Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)									0.469388	146.284881	146.359854	46	52	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(66;0.0724)		Silent	SNP	40743256	40743256	1164	19	G	A	A	39	39	ATP4A	A	1	1
ANKRD24	170961	broad.mit.edu	36	19	4158777	4158777	+	Splice_Site_SNP	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:4158777G>A	uc010dtt.1	+	c.645_splice	c.e10-1	p.R215_splice	ANKRD24_uc002lzs.2_Splice_Site_SNP_p.R186_splice|ANKRD24_uc002lzt.2_Splice_Site_SNP_p.R187_splice	NM_133475	NP_597732			ankyrin repeat domain 24												0												OREG0025162	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.8	39.799134	41.050854	12	3	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)	Splice_Site_SNP	SNP	4158777	4158777	658	19	G	A	A	35	35	ANKRD24	A	5	2
EPS8L1	54869	broad.mit.edu	36	19	60285483	60285483	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:60285483C>T	uc002qis.2	+	c.1019C>T	c.(1018-1020)CCC>CTC	p.P340L	EPS8L1_uc010ess.1_Missense_Mutation_p.P322L|EPS8L1_uc010est.1_Missense_Mutation_p.P340L|EPS8L1_uc010esu.1_Non-coding_Transcript|EPS8L1_uc002qiu.1_Missense_Mutation_p.P213L|EPS8L1_uc002qiv.1_5'UTR|EPS8L1_uc002qiw.1_Missense_Mutation_p.P87L	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	340						cytoplasm					0						Ovarian(149;255 1863 3636 27051 29647)								0.583333	68.37512	68.592395	21	15	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)	Missense_Mutation	SNP	60285483	60285483	5388	19	C	T	T	22	22	EPS8L1	T	2	2
ZFP28	140612	broad.mit.edu	36	19	61757907	61757907	+	Missense_Mutation	SNP	T	G	G			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr19:61757907T>G	uc002qnj.1	+	c.1941T>G	c.(1939-1941)TGT>TGG	p.C647W		NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	647	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)				Ovarian(124;554 1662 19430 21141 52494)								0.4375	168.165126	168.54526	49	63	TT		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(193;0.0302)	Missense_Mutation	SNP	61757907	61757907	18230	19	T	G	G	57	57	ZFP28	G	4	4
TRIM11	81559	broad.mit.edu	36	1	226649258	226649258	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:226649258G>A	uc001hss.1	-	c.1178C>T	c.(1177-1179)GCC>GTC	p.A393V		NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	393	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding				0		Prostate(94;0.0724)												0.443609	172.730822	173.094081	59	74	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	226649258	226649258	17031	1	G	A	A	42	42	TRIM11	A	2	2
C22orf32	91689	broad.mit.edu	36	22	40805738	40805738	+	Missense_Mutation	SNP	G	C	C			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:40805738G>C	uc003bca.1	+	c.20G>C	c.(19-21)CGC>CCC	p.R7P		NM_033318	NP_201575	Q9H4I9	CV032_HUMAN	hypothetical protein LOC91689	7						integral to membrane|mitochondrion				ovary(1)	1														0.294118	6.645709	7.320196	5	12	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	40805738	40805738	2225	22	G	C	C	38	38	C22orf32	C	3	3
THSD7B	80731	broad.mit.edu	36	2	137531234	137531234	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:137531234C>T	uc002tva.1	+	c.821C>T	c.(820-822)TCG>TTG	p.S274L	THSD7B_uc002tvb.2_Missense_Mutation_p.S164L	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7														0.483333	91.373394	91.387815	29	31	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(221;0.19)	Missense_Mutation	SNP	137531234	137531234	16408	2	C	T	T	31	31	THSD7B	T	1	1
OBFC2A	64859	broad.mit.edu	36	2	192254962	192254962	+	Silent	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:192254962G>A	uc002usx.1	+	c.276G>A	c.(274-276)AGG>AGA	p.R92R	OBFC2A_uc002usw.1_Silent_p.R12R|OBFC2A_uc002usy.1_Non-coding_Transcript|OBFC2A_uc002usz.1_Non-coding_Transcript|OBFC2A_uc002uta.1_Silent_p.R12R	NM_001031716	NP_001026886	Q96AH0	SOSB2_HUMAN	oligonucleotide/oligosaccharide-binding fold	92	OB.				double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	single-stranded DNA binding				0														0.421053	76.790188	77.100364	24	33	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(117;0.061)|Epithelial(96;0.244)		Silent	SNP	192254962	192254962	11213	2	G	A	A	43	43	OBFC2A	A	2	2
RPE	6120	broad.mit.edu	36	2	210589518	210589518	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:210589518G>A	uc002vdn.1	+	c.385G>A	c.(385-387)GCA>ACA	p.A129T	RPE_uc002vdm.1_Missense_Mutation_p.A129T|RPE_uc002vdo.1_Missense_Mutation_p.A79T|RPE_uc002vdp.1_Missense_Mutation_p.A76T|RPE_uc010fup.1_Missense_Mutation_p.A61T|RPE_uc002vdq.1_Missense_Mutation_p.A79T|RPE_uc002vdr.1_Intron	NM_199229	NP_954699	Q96AT9	RPE_HUMAN	ribulose-5-phosphate-3-epimerase isoform 1	129					pentose-phosphate shunt	cytosol	protein binding|ribulose-phosphate 3-epimerase activity				0														0.146667	34.643609	52.648486	22	128	GG		KEEP	---	---	---	---	capture		Epithelial(149;0.00241)|Lung(261;0.041)|all cancers(144;0.0429)|LUSC - Lung squamous cell carcinoma(261;0.0431)	Missense_Mutation	SNP	210589518	210589518	14023	2	G	A	A	42	42	RPE	A	2	2
OTUD4	54726	broad.mit.edu	36	4	146279210	146279210	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:146279210G>A	uc003ika.2	-	c.1972C>T	c.(1972-1974)CCT>TCT	p.P658S	OTUD4_uc003ijz.2_Missense_Mutation_p.P657S	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	722							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)													0.377953	145.069457	146.729336	48	79	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	146279210	146279210	11727	4	G	A	A	43	43	OTUD4	A	2	2
OTOP1	133060	broad.mit.edu	36	4	4279319	4279319	+	Silent	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:4279319G>A	uc003ghp.1	-	c.174C>T	c.(172-174)GCC>GCT	p.A58A		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	58					biomineral tissue development	extracellular space|integral to membrane				ovary(2)	2														0.2	7.987445	9.663212	4	16	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (64;0.168)	Silent	SNP	4279319	4279319	11717	4	G	A	A	39	39	OTOP1	A	1	1
KIT	3815	broad.mit.edu	36	4	55256583	55256583	+	Missense_Mutation	SNP	T	A	A			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr4:55256583T>A	uc010igr.1	+	c.216T>A	c.(214-216)GAT>GAA	p.D72E	KIT_uc010igs.1_Missense_Mutation_p.D72E	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	72	Extracellular (Potential).|Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3041)|haematopoietic_and_lymphoid_tissue(1544)|skin(98)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(10)|lung(6)|thymus(5)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	4855	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)				Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)			1		431				0.402174	117.361619	118.129776	37	55	TT		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Missense_Mutation	SNP	55256583	55256583	8641	4	T	A	A	51	51	KIT	A	4	4
MAN2B2	23324	broad.mit.edu	36	4	6649777	6649777	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:6649777G>A	uc003gjf.1	+	c.1094G>A	c.(1093-1095)CGC>CAC	p.R365H	MAN2B2_uc003gje.1_Missense_Mutation_p.R365H	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	365					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2														0.453488	337.649397	338.132979	117	141	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	6649777	6649777	9600	4	G	A	A	38	38	MAN2B2	A	1	1
FTMT	94033	broad.mit.edu	36	5	121215740	121215740	+	Silent	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:121215740C>T	uc003kss.1	+	c.183C>T	c.(181-183)CCC>CCT	p.P61P		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	mitochondrial ferritin	61					cellular iron ion homeostasis|iron ion transport|oxidation-reduction process|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)												0.395349	52.165796	52.578013	17	26	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)	Silent	SNP	121215740	121215740	6336	5	C	T	T	23	23	FTMT	T	1	1
DNAH5	1767	broad.mit.edu	36	5	13894119	13894119	+	Missense_Mutation	SNP	T	C	C			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr5:13894119T>C	uc003jfd.2	-	c.5605A>G	c.(5605-5607)ACA>GCA	p.T1869A		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1869	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|breast(1)|central_nervous_system(1)|pancreas(1)	17	Lung NSC(4;0.00476)													0.45509	271.300858	271.591459	76	91	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	13894119	13894119	4787	5	T	C	C	57	57	DNAH5	C	4	4
C5orf25	375484	broad.mit.edu	36	5	175650382	175650382	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:175650382C>T	uc010jka.1	+	c.1249C>T	c.(1249-1251)CCA>TCA	p.P417S	C5orf25_uc003mdr.2_Intron|C5orf25_uc003mds.2_Missense_Mutation_p.P398S|C5orf25_uc003mdt.2_Intron|C5orf25_uc010jkb.1_Missense_Mutation_p.P398S	NM_198567	NP_940969	Q8NDZ2	CE025_HUMAN	hypothetical protein LOC375484	398											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)												0.362963	140.834906	143.06694	49	86	CC		KEEP	---	---	---	---	capture	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)	Missense_Mutation	SNP	175650382	175650382	2386	5	C	T	T	22	22	C5orf25	T	2	2
RNF130	55819	broad.mit.edu	36	5	179400241	179400241	+	Missense_Mutation	SNP	A	T	T			TCGA-32-2634-01	TCGA-32-2634-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:179400241A>T	uc003mll.1	-	c.260T>A	c.(259-261)CTG>CAG	p.L87Q	RNF130_uc003mlm.1_Missense_Mutation_p.L87Q	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130	87	Extracellular (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)				GBM(24;432 554 38471 39699 51728)				168				0.275862	43.774827	46.398175	16	42	AA		KEEP	---	---	---	---	capture	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Missense_Mutation	SNP	179400241	179400241	13915	5	A	T	T	7	7	RNF130	T	4	4
PRDM9	56979	broad.mit.edu	36	5	23558182	23558182	+	Missense_Mutation	SNP	A	G	G			TCGA-32-2634-01	TCGA-32-2634-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:23558182A>G	uc003jgo.1	+	c.521A>G	c.(520-522)AAG>AGG	p.K174R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	174					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6														0.421875	285.056153	286.075823	81	111	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	23558182	23558182	12906	5	A	G	G	3	3	PRDM9	G	4	4
PIK3R1	5295	broad.mit.edu	36	5	67626877	67626877	+	Nonsense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:67626877C>T	uc003jva.1	+	c.1714C>T	c.(1714-1716)CAG>TAG	p.Q572*	PIK3R1_uc003jvb.1_Nonsense_Mutation_p.Q572*|PIK3R1_uc003jvc.1_Nonsense_Mutation_p.Q272*|PIK3R1_uc003jvd.1_Nonsense_Mutation_p.Q302*|PIK3R1_uc003jve.1_Nonsense_Mutation_p.Q251*	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	572					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.L570_D578del(1)|p.L570_Q572del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(5)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	99		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)			Isoproterenol(DB01064)					370	TCGA GBM(4;<1E-8)			0.390977	154.865976	156.251981	52	81	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Nonsense_Mutation	SNP	67626877	67626877	12342	5	C	T	T	21	21	PIK3R1	T	5	2
PACRG	135138	broad.mit.edu	36	6	163155299	163155299	+	Nonsense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:163155299G>A	uc003qua.1	+	c.287G>A	c.(286-288)TGG>TAG	p.W96*	PACRG_uc003qub.1_Nonsense_Mutation_p.W96*|PACRG_uc003quc.1_Nonsense_Mutation_p.W96*	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	96											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)												0.461957	261.855199	262.087142	85	99	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)	Nonsense_Mutation	SNP	163155299	163155299	11786	6	G	A	A	47	47	PACRG	A	5	2
ATG9B	285973	broad.mit.edu	36	7	150352126	150352126	+	Silent	SNP	T	G	G			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr7:150352126T>G	uc010lpv.1	-	c.318A>C	c.(316-318)ACA>ACC	p.T106T	ATG9B_uc003wig.2_5'Flank	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	106	Pro-rich.|Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)													0.333333	6.572456	7.051597	6	12	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Silent	SNP	150352126	150352126	1122	7	T	G	G	59	59	ATG9B	G	4	4
IL6	3569	broad.mit.edu	36	7	22735707	22735707	+	Missense_Mutation	SNP	A	T	T			TCGA-32-2634-01	TCGA-32-2634-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:22735707A>T	uc003svj.2	+	c.374A>T	c.(373-375)TAC>TTC	p.Y125F		NM_000600	NP_000591	P05231	IL6_HUMAN	interleukin 6	125					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|humoral immune response|interleukin-6-mediated signaling pathway|monocyte chemotaxis|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|neutrophil mediated immunity|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of gene-specific transcription|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of angiogenesis|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding				0					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	Esophageal Squamous(47;342 1214 13936 33513)								0.456376	209.894523	210.139802	68	81	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	22735707	22735707	8002	7	A	T	T	14	14	IL6	T	4	4
NOD1	10392	broad.mit.edu	36	7	30462908	30462908	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:30462908G>A	uc003tav.1	-	c.155C>T	c.(154-156)GCC>GTC	p.A52V	NOD1_uc003tax.1_3'UTR|NOD1_uc003tay.1_Non-coding_Transcript|NOD1_uc010kvt.1_Non-coding_Transcript|NOD1_uc010kvu.1_Non-coding_Transcript	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	52	CARD.				activation of caspase activity|activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)	1														0.425532	118.687913	119.141635	40	54	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	30462908	30462908	10919	7	G	A	A	42	42	NOD1	A	2	2
ABCA13	154664	broad.mit.edu	36	7	48288572	48288572	+	Missense_Mutation	SNP	C	G	G			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:48288572C>G	uc003toq.1	+	c.7070C>G	c.(7069-7071)GCT>GGT	p.A2357G	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2412					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10														0.5	168.552035	168.552035	46	46	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48288572	48288572	32	7	C	G	G	28	28	ABCA13	G	3	3
RABGEF1	27342	broad.mit.edu	36	7	65877793	65877793	+	Silent	SNP	T	C	C			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr7:65877793T>C	uc003tvh.1	+	c.324T>C	c.(322-324)TCT>TCC	p.S108S	RABGEF1_uc003tvf.1_5'UTR|RABGEF1_uc003tvg.1_5'UTR|RABGEF1_uc010lag.1_Silent_p.S108S|RABGEF1_uc003tvi.1_5'UTR	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	286					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1														0.404762	119.034908	119.699912	34	50	TT		KEEP	---	---	---	---	capture			Silent	SNP	65877793	65877793	13425	7	T	C	C	56	56	RABGEF1	C	4	4
SEMA3C	10512	broad.mit.edu	36	7	80268072	80268072	+	Missense_Mutation	SNP	A	T	T			TCGA-32-2634-01	TCGA-32-2634-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:80268072A>T	uc003uhj.1	-	c.923T>A	c.(922-924)GTG>GAG	p.V308E		NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C	308	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1														0.138686	28.430426	45.725559	19	118	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	80268072	80268072	14512	7	A	T	T	6	6	SEMA3C	T	4	4
CACNA2D1	781	broad.mit.edu	36	7	81429192	81429192	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2634-01	TCGA-32-2634-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:81429192C>T	uc003uhr.1	-	c.2920G>A	c.(2920-2922)GAC>AAC	p.D974N		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	986	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)									0.366667	97.453313	98.859297	33	57	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	81429192	81429192	2664	7	C	T	T	31	31	CACNA2D1	T	1	1
NFKBIL2	4796	broad.mit.edu	36	8	145632114	145632114	+	Missense_Mutation	SNP	T	C	C			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr8:145632114T>C	uc003zcu.2	-	c.2033A>G	c.(2032-2034)GAG>GGG	p.E678G		NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	837					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)													0.28125	14.753362	16.217496	9	23	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)		Missense_Mutation	SNP	145632114	145632114	10782	8	T	C	C	54	54	NFKBIL2	C	4	4
SLC6A14	11254	broad.mit.edu	36	X	115487984	115487984	+	Nonsense_Mutation	SNP	G	T	T			TCGA-32-2634-01	TCGA-32-2634-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:115487984G>T	uc004eqi.1	+	c.448G>T	c.(448-450)GAA>TAA	p.E150*		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	150	Extracellular (Potential).				cellular amino acid metabolic process|response to toxin	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)									0.852941	281.582899	293.784757	87	15	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	115487984	115487984	15174	23	G	T	T	45	45	SLC6A14	T	5	3
TFE3	7030	broad.mit.edu	36	X	48783803	48783803	+	Missense_Mutation	SNP	T	G	G			TCGA-32-2634-01	TCGA-32-2634-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chrX:48783803T>G	uc004dmd.1	-	c.307A>C	c.(307-309)ACC>CCC	p.T103P	TFE3_uc004dmb.2_Missense_Mutation_p.T103P|TFE3_uc004dmc.2_5'UTR|TFE3_uc004dme.1_Non-coding_Transcript	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	103					humoral immune response|positive regulation of gene-specific transcription from RNA polymerase II promoter	cytoplasm|nucleus	promoter binding|sequence-specific DNA binding transcription factor activity|transcription regulator activity		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197										48				0.416667	6.826536	6.930241	5	7	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48783803	48783803	16328	23	T	G	G	58	58	TFE3	G	4	4
EXPH5	23086	broad.mit.edu	36	11	107888442	107888442	+	Frame_Shift_Del	DEL	C	-	-			TCGA-32-2634-01	TCGA-32-2634-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:107888442_107888442delC	uc001pkk.1	-	c.3002_3002delG	c.(3001-3003)AGCfs	p.S1001fs		NM_015065	NP_055880	Q149M6	Q149M6_HUMAN	exophilin 5 isoform a	1001					intracellular protein transport		Rab GTPase binding			ovary(2)	2		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)										0.44			90	116				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	107888442	107888442	5516	11	C	-	-	28	28	EXPH5	-	5	5
KDM1A	23028	broad.mit.edu	36	1	23254175	23254176	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-32-2634-01	TCGA-32-2634-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:23254175_23254176delCA	uc001bgj.1	+	c.817_818delCA	c.(817-819)CACfs	p.H273fs	KDM1A_uc001bgi.1_Frame_Shift_Del_p.H253fs	NM_015013	NP_055828	O60341	KDM1A_HUMAN	amine oxidase (flavin containing) domain 2	253	SWIRM.				blood coagulation|muscle cell development|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|oxidation-reduction process|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|promoter binding|transcription repressor activity			ovary(1)|lung(1)	2														0.70			169	73				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	23254175	23254176	8428	1	CA	-	-	29	29	KDM1A	-	5	5
NISCH	11188	broad.mit.edu	36	3	52496469	52496480	+	In_Frame_Del	DEL	GAGGAGGAGGAA	-	-			TCGA-32-2634-01	TCGA-32-2634-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:52496469_52496480delGAGGAGGAGGAA	uc003ded.2	+	c.1921_1932delGAGGAGGAGGAA	c.(1921-1932)GAGGAGGAGGAAdel	p.EEEE641del	NISCH_uc003dee.2_In_Frame_Del_p.EEEE130del|NISCH_uc003deg.1_Non-coding_Transcript	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	641_644	Necessary for homooligomerization and targeting to endosomes.|Potential.|Glu-rich.|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)										0.34			25	48				---	---	---	---	capture_indel			In_Frame_Del	DEL	52496469	52496480	10833	3	GAGGAGGAGGAA	-	-	45	45	NISCH	-	5	5
PODXL	5420	broad.mit.edu	36	7	130891570	130891575	+	In_Frame_Del	DEL	GGCGAC	-	-			TCGA-32-2634-01	TCGA-32-2634-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:130891570_130891575delGGCGAC	uc003vqw.2	-	c.84_89delGTCGCC	c.(82-90)CCGTCGCCC>CCC	p.28_30PSP>P	PODXL_uc003vqx.2_In_Frame_Del_p.28_30PSP>P	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	28_30	Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)													0.33			2	4				---	---	---	---	capture_indel			In_Frame_Del	DEL	130891570	130891575	12608	7	GGCGAC	-	-	43	43	PODXL	-	5	5
WDYHV1	55093	broad.mit.edu	36	8	124509354	124509354	+	Frame_Shift_Del	DEL	T	-	-			TCGA-32-2634-01	TCGA-32-2634-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:124509354_124509354delT	uc003yqn.1	+	c.93_93delT	c.(91-93)AATfs	p.N31fs	WDYHV1_uc003yqo.1_5'Flank	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	31					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)	1														0.45			120	144				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	124509354	124509354	17917	8	T	-	-	49	49	WDYHV1	-	5	5
