Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
KIAA1462	57608	broad.mit.edu	36	10	30376593	30376593	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:30376593G>A	uc009xle.1	-	c.155C>T	c.(154-156)GCG>GTG	p.A52V	KIAA1462_uc001iuz.2_5'UTR|KIAA1462_uc001iux.2_Missense_Mutation_p.A52V|KIAA1462_uc001iuy.2_Missense_Mutation_p.A52V	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	52										ovary(4)	4														0.627907	172.564794	173.8004	54	32	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	30376593	30376593	8543	10	G	A	A	38	38	KIAA1462	A	1	1
SIK3	23387	broad.mit.edu	36	11	116237253	116237253	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:116237253C>T	uc001ppy.1	-	c.2054G>A	c.(2053-2055)AGG>AAG	p.R685K	SIK3_uc001ppz.1_Missense_Mutation_p.R584K|SIK3_uc001pqa.1_Missense_Mutation_p.R685K|SIK3_uc001ppw.1_Missense_Mutation_p.R102K|SIK3_uc001ppx.1_Intron|SIK3_uc001pqb.1_5'UTR	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	KIAA0999 protein	685	Gln-rich.				protein phosphorylation	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|breast(2)|lung(1)|kidney(1)|skin(1)	8										634		OREG0003492	type=REGULATORY REGION|Gene=BC035583|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0.345794	112.240566	114.488107	37	70	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	116237253	116237253	14814	11	C	T	T	24	24	SIK3	T	2	2
TMPRSS4	56649	broad.mit.edu	36	11	117490838	117490838	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:117490838C>T	uc009yzt.1	+	c.995C>T	c.(994-996)ACG>ATG	p.T332M	TMPRSS4_uc001psd.2_Missense_Mutation_p.T327M|TMPRSS4_uc009yzu.1_Non-coding_Transcript|TMPRSS4_uc009yzv.1_Missense_Mutation_p.T307M	NM_019894	NP_063947	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4 isoform 1	332	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)												0.266667	10.293875	11.031149	4	11	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)	Missense_Mutation	SNP	117490838	117490838	16790	11	C	T	T	19	19	TMPRSS4	T	1	1
TECTA	7007	broad.mit.edu	36	11	120542669	120542669	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:120542669C>T	uc001pxr.1	+	c.5556C>T	c.(5554-5556)AAC>AAT	p.N1852N		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1852	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)	8	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)												0.268657	41.112629	44.355233	18	49	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)	Silent	SNP	120542669	120542669	16274	11	C	T	T	17	17	TECTA	T	2	2
OR51T1	401665	broad.mit.edu	36	11	4860609	4860609	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:4860609C>T	uc001lzp.1	+	c.985C>T	c.(985-987)CGC>TGC	p.R329C		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)												0.327273	102.577019	105.480121	36	74	CC		KEEP	---	---	---	---	capture		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)	Missense_Mutation	SNP	4860609	4860609	11516	11	C	T	T	23	23	OR51T1	T	1	1
TRIM22	10346	broad.mit.edu	36	11	5686993	5686993	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:5686993G>A	uc001mbr.1	+	c.1036G>A	c.(1036-1038)GGC>AGC	p.G346S	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.1_Missense_Mutation_p.G342S|TRIM22_uc009yeu.1_Missense_Mutation_p.G157S|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	346	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|regulation of transcription, DNA-dependent|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)				GBM(104;491 2336 5222)								0.311111	109.697067	113.98922	42	93	GG		KEEP	---	---	---	---	capture		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)	Missense_Mutation	SNP	5686993	5686993	17040	11	G	A	A	39	39	TRIM22	A	1	1
MPEG1	219972	broad.mit.edu	36	11	58735259	58735259	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:58735259C>T	uc001nnu.2	-	c.1656G>A	c.(1654-1656)CCG>CCA	p.P552P		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1	552	Extracellular (Potential).					integral to membrane				ovary(1)	1		all_epithelial(135;0.125)												0.107843	8.554618	24.109228	11	91	CC		KEEP	---	---	---	---	capture			Silent	SNP	58735259	58735259	10115	11	C	T	T	19	19	MPEG1	T	1	1
KRTAP5-9	3846	broad.mit.edu	36	11	70937696	70937696	+	Silent	SNP	T	C	C			TCGA-32-2638-01	TCGA-32-2638-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:70937696T>C	uc001oqs.1	+	c.345T>C	c.(343-345)TGT>TGC	p.C115C		NM_005553	NP_005544	P26371	KRA59_HUMAN	keratin associated protein 5-9	115	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament					0														0.35	235.81472	240.179329	77	143	TT		KEEP	---	---	---	---	capture			Silent	SNP	70937696	70937696	8890	11	T	C	C	60	60	KRTAP5-9	C	4	4
CLEC12A	160364	broad.mit.edu	36	12	10023293	10023293	+	Missense_Mutation	SNP	G	T	T			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:10023293G>T	uc001qwq.1	+	c.312G>T	c.(310-312)ATG>ATT	p.M104I	CLEC12A_uc001qwr.2_Missense_Mutation_p.M94I|CLEC12A_uc001qws.2_Missense_Mutation_p.M61I|CLEC12A_uc001qwt.1_Missense_Mutation_p.M23I	NM_138337	NP_612210	Q5QGZ9	CL12A_HUMAN	myeloid inhibitory C-type lectin-like receptor	94	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity|sugar binding				0						Melanoma(197;1487 2125 16611 22221 34855)								0.434783	59.792271	59.963032	20	26	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	10023293	10023293	3634	12	G	T	T	45	45	CLEC12A	T	3	3
ACACB	32	broad.mit.edu	36	12	108094025	108094025	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:108094025G>A	uc001tob.1	+	c.958G>A	c.(958-960)GTC>ATC	p.V320I	ACACB_uc001toc.1_Missense_Mutation_p.V320I	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	320	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|pancreas(1)	6					Biotin(DB00121)					1843				0.12069	8.707617	16.869293	7	51	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	108094025	108094025	108	12	G	A	A	40	40	ACACB	A	1	1
ITGB7	3695	broad.mit.edu	36	12	51876790	51876790	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:51876790C>T	uc009zmv.1	-	c.656G>A	c.(655-657)CGG>CAG	p.R219Q	ITGB7_uc001scc.1_Missense_Mutation_p.R219Q	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7	219	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|urinary_tract(1)|breast(1)|skin(1)	6														0.266667	20.294361	21.764791	8	22	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	51876790	51876790	8204	12	C	T	T	23	23	ITGB7	T	1	1
KCTD12	115207	broad.mit.edu	36	13	76357430	76357430	+	Silent	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr13:76357430G>A	uc010aeu.1	-	c.855C>T	c.(853-855)TCC>TCT	p.S285S	KCTD12_uc001vka.1_Silent_p.S285S	NM_138444	NP_612453	Q96CX2	KCD12_HUMAN	potassium channel tetramerisation domain	285						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(1)	1		Breast(118;0.212)										OREG0022449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.222222	15.237157	17.152433	6	21	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(99;0.0499)	Silent	SNP	76357430	76357430	8405	13	G	A	A	39	39	KCTD12	A	1	1
TNFAIP2	7127	broad.mit.edu	36	14	102667755	102667755	+	Missense_Mutation	SNP	T	G	G			TCGA-32-2638-01	TCGA-32-2638-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr14:102667755T>G	uc001ymm.1	+	c.1325T>G	c.(1324-1326)GTA>GGA	p.V442G	TNFAIP2_uc010awo.1_Missense_Mutation_p.V154G	NM_006291	NP_006282	Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	442					angiogenesis|cell differentiation	extracellular space				central_nervous_system(1)	1		Melanoma(154;0.155)												0.333333	7.368413	8.016222	7	14	TT		KEEP	---	---	---	---	capture	Epithelial(46;0.191)		Missense_Mutation	SNP	102667755	102667755	16814	14	T	G	G	57	57	TNFAIP2	G	4	4
KCNH5	27133	broad.mit.edu	36	14	62517562	62517562	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr14:62517562C>T	uc001xfx.1	-	c.723G>A	c.(721-723)AAG>AAA	p.K241K	KCNH5_uc001xfy.1_Silent_p.K241K|KCNH5_uc001xfz.1_Silent_p.K183K|KCNH5_uc001xga.2_Silent_p.K183K	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	241	Extracellular (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|central_nervous_system(1)	5														0.323944	61.188115	63.148182	23	48	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)	Silent	SNP	62517562	62517562	8340	14	C	T	T	28	28	KCNH5	T	2	2
KIAA1409	57578	broad.mit.edu	36	14	93122709	93122709	+	Missense_Mutation	SNP	A	G	G			TCGA-32-2638-01	TCGA-32-2638-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr14:93122709A>G	uc001ybv.1	+	c.2287A>G	c.(2287-2289)ACC>GCC	p.T763A	KIAA1409_uc001ybs.1_Missense_Mutation_p.T763A	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	940						integral to membrane				ovary(10)|large_intestine(3)	13		all_cancers(154;0.0354)|all_epithelial(191;0.216)								1186				0.385714	90.217262	91.015677	27	43	AA		KEEP	---	---	---	---	capture		Epithelial(152;0.188)	Missense_Mutation	SNP	93122709	93122709	8539	14	A	G	G	14	14	KIAA1409	G	4	4
SERPINA9	327657	broad.mit.edu	36	14	94003411	94003411	+	Silent	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:94003411G>A	uc001ydf.1	-	c.744C>T	c.(742-744)GGC>GGT	p.G248G	SERPINA9_uc001yde.1_Silent_p.G148G|SERPINA9_uc010avc.1_Silent_p.G99G|SERPINA9_uc001ydg.1_Silent_p.G212G|SERPINA9_uc001ydh.1_Silent_p.G248G|SERPINA9_uc001ydi.1_Silent_p.G212G	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	230					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)												0.476923	93.127342	93.156815	31	34	GG		KEEP	---	---	---	---	capture		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)	Silent	SNP	94003411	94003411	14583	14	G	A	A	38	38	SERPINA9	A	1	1
POTEB	339010	broad.mit.edu	36	15	19335898	19335898	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:19335898C>T	uc001ytu.1	-	c.403G>A	c.(403-405)GTC>ATC	p.V135I	POTEB_uc010axv.1_Non-coding_Transcript	NM_207355	NP_997238	Q6S5H4	POTEB_HUMAN	protein expressed in prostate, ovary, testis,	135											0														0.112088	43.910362	111.547725	51	404	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	19335898	19335898	12691	15	C	T	T	19	19	POTEB	T	1	1
PRRT2	112476	broad.mit.edu	36	16	29732498	29732498	+	Missense_Mutation	SNP	T	C	C			TCGA-32-2638-01	TCGA-32-2638-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr16:29732498T>C	uc002dud.2	+	c.622T>C	c.(622-624)TCC>CCC	p.S208P	BOLA2_uc010bzb.1_Intron|BOLA2_uc010bzc.1_Intron|PRRT2_uc002due.2_Missense_Mutation_p.S208P|PRRT2_uc002duf.1_Missense_Mutation_p.S208P|C16orf53_uc002dug.2_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	208	Extracellular (Potential).|Pro-rich.				response to biotic stimulus	integral to membrane					0														0.21875	9.052283	11.371504	7	25	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	29732498	29732498	13059	16	T	C	C	50	50	PRRT2	C	4	4
OGFOD1	55239	broad.mit.edu	36	16	55062094	55062094	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:55062094C>T	uc002ejb.1	+	c.1175C>T	c.(1174-1176)ACT>ATT	p.T392I	OGFOD1_uc002ejc.1_Missense_Mutation_p.T252I	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	392					oxidation-reduction process		iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)									0.190476	7.386347	9.268757	4	17	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55062094	55062094	11246	16	C	T	T	20	20	OGFOD1	T	2	2
HYDIN	54768	broad.mit.edu	36	16	69452253	69452253	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:69452253G>A	uc002ezr.1	-	c.11827C>T	c.(11827-11829)CGG>TGG	p.R3943W	HYDIN_uc010cfy.1_Non-coding_Transcript	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3944										ovary(1)	1		Ovarian(137;0.0654)												0.151515	29.75027	45.079769	20	112	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	69452253	69452253	7767	16	G	A	A	38	38	HYDIN	A	1	1
GSDMB	55876	broad.mit.edu	36	17	35315926	35315926	+	Silent	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:35315926G>A	uc010cwj.1	-	c.852C>T	c.(850-852)CTC>CTT	p.L284L	GSDMB_uc010cwi.1_Silent_p.L31L|GSDMB_uc010cwk.1_Non-coding_Transcript|GSDMB_uc010cwl.1_Non-coding_Transcript|GSDMB_uc010cwm.1_Non-coding_Transcript|GSDMB_uc002htg.1_Silent_p.L262L|GSDMB_uc002hth.1_Silent_p.L271L	NM_001042471	NP_001035936	Q8TAX9	GSDMB_HUMAN	gasdermin-like isoform 1	279						cytoplasm				breast(1)|pancreas(1)	2														0.395349	148.394764	149.631983	51	78	GG		KEEP	---	---	---	---	capture			Silent	SNP	35315926	35315926	7097	17	G	A	A	37	37	GSDMB	A	1	1
VPS53	55275	broad.mit.edu	36	17	387133	387133	+	Nonsense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:387133G>A	uc010cjo.1	-	c.1900C>T	c.(1900-1902)CAG>TAG	p.Q634*	VPS53_uc002frk.2_Nonsense_Mutation_p.Q153*|VPS53_uc002frl.2_Non-coding_Transcript|VPS53_uc002frm.2_Nonsense_Mutation_p.Q605*|VPS53_uc002frn.2_Nonsense_Mutation_p.Q634*|VPS53_uc002fro.2_Nonsense_Mutation_p.Q436*|VPS53_uc010cjp.1_Nonsense_Mutation_p.Q357*	NM_001128159	NP_001121631	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 1	634					protein transport	endosome membrane|Golgi apparatus					0														0.333333	47.910875	49.078469	16	32	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)	Nonsense_Mutation	SNP	387133	387133	17782	17	G	A	A	47	47	VPS53	A	5	2
ITGA3	3675	broad.mit.edu	36	17	45511216	45511216	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:45511216G>A	uc010dbm.1	+	c.2327G>A	c.(2326-2328)GGG>GAG	p.G776E	ITGA3_uc010dbl.1_Missense_Mutation_p.G776E	NM_005501	NP_005492	P26006	ITA3_HUMAN	integrin alpha 3 isoform b precursor	776	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3														0.325843	162.58668	167.377664	58	120	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	45511216	45511216	8181	17	G	A	A	43	43	ITGA3	A	2	2
ANKRD40	91369	broad.mit.edu	36	17	46131812	46131812	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:46131812G>A	uc002iso.1	-	c.725C>T	c.(724-726)GCG>GTG	p.A242V		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	242	Pro-rich.										0														0.481013	217.160541	217.21072	76	82	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(22;2.03e-09)		Missense_Mutation	SNP	46131812	46131812	677	17	G	A	A	38	38	ANKRD40	A	1	1
COIL	8161	broad.mit.edu	36	17	52382962	52382962	+	Missense_Mutation	SNP	G	T	T			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:52382962G>T	uc002iuu.1	-	c.640C>A	c.(640-642)CAG>AAG	p.Q214K		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	214						Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)													0.412088	213.565211	214.79966	75	107	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	52382962	52382962	3803	17	G	T	T	45	45	COIL	T	3	3
ABCA9	10350	broad.mit.edu	36	17	64492683	64492683	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:64492683C>T	uc002jhu.1	-	c.4317G>A	c.(4315-4317)CCG>CCA	p.P1439P	ABCA9_uc010dez.1_Silent_p.P1401P	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1439	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|central_nervous_system(1)	5	Breast(10;1.47e-12)													0.392	136.954212	138.228003	49	76	CC		KEEP	---	---	---	---	capture			Silent	SNP	64492683	64492683	40	17	C	T	T	19	19	ABCA9	T	1	1
SETBP1	26040	broad.mit.edu	36	18	40783845	40783845	+	Missense_Mutation	SNP	C	G	G			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr18:40783845C>G	uc010dni.1	+	c.380C>G	c.(379-381)GCT>GGT	p.A127G	SETBP1_uc002laz.1_Missense_Mutation_p.A127G	NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	181						nucleus	DNA binding			large_intestine(1)	1														0.423077	73.341061	73.609649	22	30	CC		KEEP	---	---	---	---	capture		Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)	Missense_Mutation	SNP	40783845	40783845	14617	18	C	G	G	28	28	SETBP1	G	3	3
SLC14A1	6563	broad.mit.edu	36	18	41564351	41564351	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr18:41564351C>T	uc010dnk.1	+	c.236C>T	c.(235-237)TCG>TTG	p.S79L	SLC14A1_uc002lbf.2_Missense_Mutation_p.S23L|SLC14A1_uc002lbg.2_Non-coding_Transcript|SLC14A1_uc002lbh.2_Intron|SLC14A1_uc002lbi.2_Intron|SLC14A1_uc002lbj.2_Missense_Mutation_p.S79L|SLC14A1_uc002lbk.2_Missense_Mutation_p.S23L	NM_001128588	NP_001122060	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	23						integral to plasma membrane	ubiquitin-ubiquitin ligase activity|urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2										201				0.349515	96.850654	98.916227	36	67	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	41564351	41564351	14891	18	C	T	T	31	31	SLC14A1	T	1	1
LRRC8E	80131	broad.mit.edu	36	19	7871735	7871735	+	Silent	SNP	G	T	T			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:7871735G>T	uc002mir.1	+	c.2328G>T	c.(2326-2328)CTG>CTT	p.L776L		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	776						integral to membrane				lung(1)|pancreas(1)	2														0.310345	96.645911	100.369384	36	80	GG		KEEP	---	---	---	---	capture			Silent	SNP	7871735	7871735	9401	19	G	T	T	47	47	LRRC8E	T	3	3
MUC16	94025	broad.mit.edu	36	19	8933143	8933143	+	Silent	SNP	T	A	A			TCGA-32-2638-01	TCGA-32-2638-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr19:8933143T>A	uc002mkp.1	-	c.15303A>T	c.(15301-15303)TCA>TCT	p.S5101S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5103	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			ovary(15)|large_intestine(1)|pancreas(1)|breast(1)|skin(1)	19														0.266667	165.788626	177.59394	64	176	TT		KEEP	---	---	---	---	capture			Silent	SNP	8933143	8933143	10367	19	T	A	A	55	55	MUC16	A	4	4
AMPD1	270	broad.mit.edu	36	1	115022619	115022619	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:115022619C>T	uc001efe.1	-	c.950G>A	c.(949-951)CGT>CAT	p.R317H	AMPD1_uc001eff.1_Missense_Mutation_p.R313H	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	317					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)			Adenosine monophosphate(DB00131)									0.392857	129.179393	130.303721	44	68	CC		KEEP	---	---	---	---	capture		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Missense_Mutation	SNP	115022619	115022619	588	1	C	T	T	19	19	AMPD1	T	1	1
ASH1L	55870	broad.mit.edu	36	1	153715865	153715865	+	Silent	SNP	G	C	C			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:153715865G>C	uc009wqq.1	-	c.3420C>G	c.(3418-3420)TCC>TCG	p.S1140S	ASH1L_uc001fkt.1_Silent_p.S1140S|ASH1L_uc009wqr.1_Silent_p.S1140S	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like	1140					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|RNA polymerase II transcription factor activity|zinc ion binding			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)													0.377778	100.325459	101.506217	34	56	GG		KEEP	---	---	---	---	capture	Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)		Silent	SNP	153715865	153715865	1060	1	G	C	C	47	47	ASH1L	C	3	3
SEC16B	89866	broad.mit.edu	36	1	176203649	176203649	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:176203649C>T	uc001glj.1	-	c.91G>A	c.(91-93)GGA>AGA	p.G31R	SEC16B_uc009wwz.1_5'UTR|SEC16B_uc001glk.1_5'UTR|SEC16B_uc001gli.1_Missense_Mutation_p.G31R|SEC16B_uc001gll.2_Missense_Mutation_p.G31R	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	31					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4														0.407407	63.037009	63.442262	22	32	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	176203649	176203649	14473	1	C	T	T	21	21	SEC16B	T	2	2
USH2A	7399	broad.mit.edu	36	1	214662179	214662179	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:214662179C>T	uc001hku.1	-	c.123G>A	c.(121-123)GAG>GAA	p.E41E	USH2A_uc001hkv.1_Silent_p.E41E	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	41	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|kidney(1)|central_nervous_system(1)	22														0.357143	89.23106	90.739083	30	54	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)	Silent	SNP	214662179	214662179	17598	1	C	T	T	32	32	USH2A	T	2	2
OBSCN	84033	broad.mit.edu	36	1	226631514	226631514	+	Silent	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:226631514G>A	uc009xez.1	+	c.23178G>A	c.(23176-23178)CCG>CCA	p.P7726P	OBSCN_uc001hsr.1_Silent_p.P2355P	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	7726	Protein kinase 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			large_intestine(7)|breast(5)|ovary(4)|skin(2)|stomach(1)|central_nervous_system(1)|pancreas(1)	21		Prostate(94;0.0405)								4006				0.428571	16.546929	16.609369	6	8	GG		KEEP	---	---	---	---	capture			Silent	SNP	226631514	226631514	11217	1	G	A	A	38	38	OBSCN	A	1	1
ZP4	57829	broad.mit.edu	36	1	236115430	236115430	+	Silent	SNP	C	G	G			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:236115430C>G	uc001hym.1	-	c.1044G>C	c.(1042-1044)GTG>GTC	p.V348V		NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	348	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(1)	1	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)				NSCLC(166;160 2029 11600 18754 19936)								0.370787	95.949524	97.25611	33	56	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Silent	SNP	236115430	236115430	18822	1	C	G	G	21	21	ZP4	G	3	3
MTMR3	8897	broad.mit.edu	36	22	28743988	28743988	+	Missense_Mutation	SNP	A	G	G			TCGA-32-2638-01	TCGA-32-2638-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr22:28743988A>G	uc003agv.2	+	c.1747A>G	c.(1747-1749)ACC>GCC	p.T583A	MTMR3_uc003agu.2_Missense_Mutation_p.T583A|MTMR3_uc003agw.2_Missense_Mutation_p.T583A	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	583					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|zinc ion binding			breast(3)|ovary(1)	4														0.385185	158.375944	159.932544	52	83	AA		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)		Missense_Mutation	SNP	28743988	28743988	10338	22	A	G	G	2	2	MTMR3	G	4	4
MKL1	57591	broad.mit.edu	36	22	39144850	39144850	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:39144850C>T	uc003ayv.1	-	c.1538G>A	c.(1537-1539)GGG>GAG	p.G513E	MKL1_uc003ayw.1_Missense_Mutation_p.G513E|MKL1_uc010gye.1_Missense_Mutation_p.G513E|MKL1_uc010gyf.1_Missense_Mutation_p.G463E	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	513					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|nucleic acid binding|transcription coactivator activity			ovary(2)|central_nervous_system(1)	3										210				0.428571	93.950732	94.259386	30	40	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	39144850	39144850	9991	22	C	T	T	22	22	MKL1	T	2	2
TEF	7008	broad.mit.edu	36	22	40120215	40120215	+	Silent	SNP	C	A	A			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:40120215C>A	uc003azy.1	+	c.645C>A	c.(643-645)CCC>CCA	p.P215P	TEF_uc003azx.1_Silent_p.P185P	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	215	Pro-rich (proline/acidic region (PAR)).				rhythmic process	nucleus	protein dimerization activity|RNA polymerase II transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1														0.36	70.819859	72.107074	27	48	CC		KEEP	---	---	---	---	capture			Silent	SNP	40120215	40120215	16277	22	C	A	A	22	22	TEF	A	3	3
TTLL8	164714	broad.mit.edu	36	22	48797097	48797097	+	Missense_Mutation	SNP	C	G	G			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:48797097C>G	uc003bjf.1	-	c.2225G>C	c.(2224-2226)CGC>CCC	p.R742P		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)												0.5	7.927781	7.92778	3	3	CC		KEEP	---	---	---	---	capture		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)	Missense_Mutation	SNP	48797097	48797097	17288	22	C	G	G	27	27	TTLL8	G	3	3
MAP4K4	9448	broad.mit.edu	36	2	101849458	101849458	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:101849458C>T	uc002tbc.1	+	c.2341C>T	c.(2341-2343)CGC>TGC	p.R781C	MAP4K4_uc002tbd.1_Missense_Mutation_p.R673C|MAP4K4_uc002tbe.1_Missense_Mutation_p.R619C|MAP4K4_uc002tbf.1_Missense_Mutation_p.R673C|MAP4K4_uc002tbg.1_Missense_Mutation_p.R703C|MAP4K4_uc002tbh.1_Missense_Mutation_p.R618C|MAP4K4_uc002tbi.1_Missense_Mutation_p.R503C|MAP4K4_uc002tbk.1_Missense_Mutation_p.R158C|MAP4K4_uc002tbl.1_De_novo_Start_OutOfFrame	NM_145686	NP_663719	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	703					intracellular protein kinase cascade|protein phosphorylation|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4										483				0.294118	65.744569	68.967411	25	60	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	101849458	101849458	9645	2	C	T	T	19	19	MAP4K4	T	1	1
ZAK	51776	broad.mit.edu	36	2	173839668	173839668	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:173839668G>A	uc002uhz.1	+	c.2347G>A	c.(2347-2349)GCC>ACC	p.A783T		NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	783					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|ovary(1)	4										532				0.588235	29.350774	29.466002	10	7	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(117;0.176)		Missense_Mutation	SNP	173839668	173839668	18095	2	G	A	A	38	38	ZAK	A	1	1
MYO1B	4430	broad.mit.edu	36	2	191969433	191969433	+	Missense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:191969433G>A	uc010fsg.1	+	c.2260G>A	c.(2260-2262)GCC>ACC	p.A754T	MYO1B_uc002usq.1_Missense_Mutation_p.A754T|MYO1B_uc002usr.1_Missense_Mutation_p.A754T|MYO1B_uc002usu.1_Missense_Mutation_p.A28T	NM_012223	NP_036355	O43795	MYO1B_HUMAN	myosin IB isoform 2	754	IQ 3.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8														0.435754	228.617171	229.262026	78	101	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)		Missense_Mutation	SNP	191969433	191969433	10464	2	G	A	A	38	38	MYO1B	A	1	1
DTNB	1838	broad.mit.edu	36	2	25527989	25527989	+	Nonsense_Mutation	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:25527989G>A	uc002rgh.1	-	c.1189C>T	c.(1189-1191)CGA>TGA	p.R397*	DTNB_uc002rgg.1_Nonsense_Mutation_p.R26*|DTNB_uc002rgi.1_Nonsense_Mutation_p.R397*|DTNB_uc002rgj.1_Nonsense_Mutation_p.R397*|DTNB_uc002rgk.1_Nonsense_Mutation_p.R367*|DTNB_uc002rgl.1_Nonsense_Mutation_p.R367*|DTNB_uc002rgm.1_Nonsense_Mutation_p.R367*|DTNB_uc002rgn.1_Nonsense_Mutation_p.R193*|DTNB_uc002rgo.1_Nonsense_Mutation_p.R188*|DTNB_uc002rgq.1_Nonsense_Mutation_p.R386*|DTNB_uc002rgr.1_Nonsense_Mutation_p.R386*	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	397						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)													0.466667	22.325085	22.339435	7	8	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	25527989	25527989	4974	2	G	A	A	39	39	DTNB	A	5	1
DUSP11	8446	broad.mit.edu	36	2	73860551	73860551	+	Missense_Mutation	SNP	C	A	A			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:73860551C>A	uc002sjp.1	-	c.59G>T	c.(58-60)CGC>CTC	p.R20L	DUSP11_uc002sjq.2_Missense_Mutation_p.R20L	NM_003584	NP_003575	O75319	DUS11_HUMAN	dual specificity phosphatase 11	20					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding				0												OREG0014714	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.291667	65.16306	68.976637	28	68	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	73860551	73860551	4996	2	C	A	A	27	27	DUSP11	A	3	3
GRK7	131890	broad.mit.edu	36	3	142979891	142979891	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:142979891C>T	uc003euf.1	+	c.75C>T	c.(73-75)TGC>TGT	p.C25C		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7	25					protein phosphorylation|visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|ovary(1)|skin(1)	4										174				0.354839	85.296183	87.044726	33	60	CC		KEEP	---	---	---	---	capture			Silent	SNP	142979891	142979891	7073	3	C	T	T	27	27	GRK7	T	1	1
TM4SF1	4071	broad.mit.edu	36	3	150576025	150576025	+	Missense_Mutation	SNP	C	G	G			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:150576025C>G	uc003exb.1	-	c.308G>C	c.(307-309)GGA>GCA	p.G103A	TM4SF1_uc003exc.1_Missense_Mutation_p.G14A	NM_014220	NP_055035	P30408	T4S1_HUMAN	transmembrane 4 superfamily member 1	103	Helical; (Probable).					integral to plasma membrane					0														0.441176	97.437512	97.643033	30	38	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)		Missense_Mutation	SNP	150576025	150576025	16496	3	C	G	G	30	30	TM4SF1	G	3	3
NAF1	92345	broad.mit.edu	36	4	164273838	164273838	+	Silent	SNP	A	G	G			TCGA-32-2638-01	TCGA-32-2638-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:164273838A>G	uc003iqj.1	-	c.951T>C	c.(949-951)GAT>GAC	p.D317D	NAF1_uc010iqw.1_Silent_p.D317D	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	317					rRNA processing	box H/ACA snoRNP complex|cytoplasm	protein binding|pseudouridine synthase activity|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)												0.467532	115.696009	115.766417	36	41	AA		KEEP	---	---	---	---	capture			Silent	SNP	164273838	164273838	10536	4	A	G	G	8	8	NAF1	G	4	4
ODZ3	55714	broad.mit.edu	36	4	183811972	183811972	+	Missense_Mutation	SNP	T	C	C			TCGA-32-2638-01	TCGA-32-2638-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr4:183811972T>C	uc003ivd.1	+	c.1043T>C	c.(1042-1044)TTT>TCT	p.F348S		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	348	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)												0.443038	116.21972	116.442194	35	44	TT		KEEP	---	---	---	---	capture		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)	Missense_Mutation	SNP	183811972	183811972	11241	4	T	C	C	64	64	ODZ3	C	4	4
ADAMTS3	9508	broad.mit.edu	36	4	73403266	73403266	+	Missense_Mutation	SNP	C	G	G			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:73403266C>G	uc003hgk.1	-	c.1372G>C	c.(1372-1374)GAT>CAT	p.D458H		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	458	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2						NSCLC(168;1941 2048 2918 13048 43078)								0.441176	101.842683	102.047542	30	38	CC		KEEP	---	---	---	---	capture	Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Missense_Mutation	SNP	73403266	73403266	268	4	C	G	G	29	29	ADAMTS3	G	3	3
MRPL1	65008	broad.mit.edu	36	4	79023504	79023504	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:79023504C>T	uc003hku.2	+	c.228C>T	c.(226-228)CCC>CCT	p.P76P	MRPL1_uc010iji.1_5'UTR	NM_020236	NP_064621	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1 precursor	76					RNA processing		RNA binding				0														0.333333	69.101781	70.799333	23	46	CC		KEEP	---	---	---	---	capture			Silent	SNP	79023504	79023504	10167	4	C	T	T	24	24	MRPL1	T	2	2
UNC5C	8633	broad.mit.edu	36	4	96309483	96309483	+	Silent	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:96309483G>A	uc003htp.1	-	c.2721C>T	c.(2719-2721)AGC>AGT	p.S907S		NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C	907	Cytoplasmic (Potential).|Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)												0.430168	216.336297	217.099333	77	102	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)	Silent	SNP	96309483	96309483	17551	4	G	A	A	46	46	UNC5C	A	2	2
SH3RF2	153769	broad.mit.edu	36	5	145373710	145373710	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:145373710C>T	uc003lnt.1	+	c.952C>T	c.(952-954)CGC>TGC	p.R318C		NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	318							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)	1														0.40201	224.229701	225.877037	80	119	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Missense_Mutation	SNP	145373710	145373710	14751	5	C	T	T	27	27	SH3RF2	T	1	1
NKAIN2	154215	broad.mit.edu	36	6	125021123	125021123	+	Silent	SNP	T	A	A			TCGA-32-2638-01	TCGA-32-2638-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr6:125021123T>A	uc003pzo.1	+	c.366T>A	c.(364-366)CCT>CCA	p.P122P	NKAIN2_uc003pzn.1_Silent_p.P122P|NKAIN2_uc003pzp.1_Silent_p.P121P|NKAIN2_uc010keq.1_Intron|NKAIN2_uc010ker.1_Silent_p.P32P	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	122						integral to membrane|plasma membrane					0														0.324561	106.140792	109.251982	37	77	TT		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(226;0.104)	Silent	SNP	125021123	125021123	10837	6	T	A	A	55	55	NKAIN2	A	4	4
NOX3	50508	broad.mit.edu	36	6	155785615	155785615	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:155785615C>T	uc003qqm.1	-	c.1213G>A	c.(1213-1215)GTT>ATT	p.V405I		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	405	Helical; (Potential).				oxidation-reduction process		electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)												0.267442	113.86757	122.273328	46	126	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)	Missense_Mutation	SNP	155785615	155785615	10961	6	C	T	T	19	19	NOX3	T	1	1
PLG	5340	broad.mit.edu	36	6	161054128	161054128	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:161054128C>T	uc003qtm.2	+	c.528C>T	c.(526-528)TGC>TGT	p.C176C		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	176	Kringle 1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			ovary(1)	1					Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)									0.349398	166.104852	169.424844	58	108	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Silent	SNP	161054128	161054128	12512	6	C	T	T	27	27	PLG	T	1	1
MUC17	140453	broad.mit.edu	36	7	100467579	100467579	+	Silent	SNP	G	A	A			TCGA-32-2638-01	TCGA-32-2638-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:100467579G>A	uc003uxp.1	+	c.6162G>A	c.(6160-6162)ACG>ACA	p.T2054T	MUC17_uc010lho.1_Non-coding_Transcript	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17	2054	Extracellular (Potential).|32.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|breast(3)|lung(2)	19	Lung NSC(181;0.136)|all_lung(186;0.182)													0.326613	219.214994	225.815701	81	167	GG		KEEP	---	---	---	---	capture			Silent	SNP	100467579	100467579	10368	7	G	A	A	38	38	MUC17	A	1	1
TFEC	22797	broad.mit.edu	36	7	115378168	115378168	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:115378168C>T	uc003vhj.1	-	c.511G>A	c.(511-513)GAT>AAT	p.D171N	TFEC_uc003vhk.1_Missense_Mutation_p.D142N|TFEC_uc003vhl.2_Missense_Mutation_p.D142N	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	171	Helix-loop-helix motif.				regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulator activity			large_intestine(1)	1														0.188406	27.130797	33.404327	13	56	CC		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(10;0.00878)		Missense_Mutation	SNP	115378168	115378168	16330	7	C	T	T	29	29	TFEC	T	2	2
TBX20	57057	broad.mit.edu	36	7	35208654	35208654	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:35208654C>T	uc003ter.1	-	c.1257G>A	c.(1255-1257)CCG>CCA	p.P419P		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20 isoform A	419						nucleus	DNA binding			central_nervous_system(1)	1														0.166667	9.935851	13.723001	6	30	CC		KEEP	---	---	---	---	capture			Silent	SNP	35208654	35208654	16182	7	C	T	T	27	27	TBX20	T	1	1
NPC1L1	29881	broad.mit.edu	36	7	44526943	44526943	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:44526943C>T	uc003tlb.1	-	c.3082G>A	c.(3082-3084)GGC>AGC	p.G1028S	NPC1L1_uc003tla.1_Missense_Mutation_p.G31S|NPC1L1_uc003tlc.1_Missense_Mutation_p.G1028S	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1028	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)	4					Ezetimibe(DB00973)									0.158273	42.266115	57.735173	22	117	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	44526943	44526943	10975	7	C	T	T	23	23	NPC1L1	T	1	1
XKR5	389610	broad.mit.edu	36	8	6666908	6666908	+	Missense_Mutation	SNP	T	G	G			TCGA-32-2638-01	TCGA-32-2638-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr8:6666908T>G	uc003wqp.1	-	c.700A>C	c.(700-702)ACC>CCC	p.T234P	XKR5_uc003wqq.1_Missense_Mutation_p.T71P|XKR5_uc003wqr.1_Non-coding_Transcript	NM_207411	NP_997294	Q6UX68	XKR5_HUMAN	XK-related protein 5a	234						integral to membrane					0														0.333333	6.820947	7.04288	3	6	TT		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)	Missense_Mutation	SNP	6666908	6666908	18015	8	T	G	G	59	59	XKR5	G	4	4
IKBKAP	8518	broad.mit.edu	36	9	110699339	110699339	+	Missense_Mutation	SNP	C	A	A			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:110699339C>A	uc004bdm.2	-	c.2411G>T	c.(2410-2412)AGT>ATT	p.S804I	IKBKAP_uc004bdl.1_Missense_Mutation_p.S455I|IKBKAP_uc010mtq.1_Missense_Mutation_p.S455I	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	804					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|breast(1)|kidney(1)	6														0.357143	126.534184	128.801577	45	81	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	110699339	110699339	7911	9	C	A	A	20	20	IKBKAP	A	3	3
CDKN2A	1029	broad.mit.edu	36	9	21961029	21961029	+	Silent	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:21961029C>T	uc003zpl.1	-	c.495G>A	c.(493-495)CTG>CTA	p.L165L	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpk.1_Nonsense_Mutation_p.W110*|CDKN2A_uc003zpj.1_3'UTR|CDKN2A_uc010miu.1_Non-coding_Transcript	NM_058195	NP_478102	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 4	Error:Variant_position_missing_in_P42771_after_alignment					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(425)|p.W110*(13)|p.H83fs*2(2)|p.A68fs*3(1)|p.D105fs*8(1)		haematopoietic_and_lymphoid_tissue(647)|skin(417)|upper_aerodigestive_tract(405)|central_nervous_system(380)|lung(319)|pancreas(237)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|ovary(76)|soft_tissue(73)|biliary_tract(71)|bone(70)|breast(46)|stomach(44)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|large_intestine(9)|salivary_gland(8)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3636		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)						17		76	TSP Lung(5;3.83e-07)			0.52	37.072855	37.081452	13	12	CC		KEEP	---	---	---	---	capture		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)	Silent	SNP	21961029	21961029	3290	9	C	T	T	21	21	CDKN2A	T	2	2
GLUD2	2747	broad.mit.edu	36	X	120009284	120009284	+	Missense_Mutation	SNP	C	T	T			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:120009284C>T	uc004eto.1	+	c.65C>T	c.(64-66)GCG>GTG	p.A22V		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	22					glutamate biosynthetic process|glutamate catabolic process|oxidation-reduction process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)									0.931034	84.79276	88.380456	27	2	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	120009284	120009284	6745	23	C	T	T	27	27	GLUD2	T	1	1
OTUD6A	139562	broad.mit.edu	36	X	69199951	69199951	+	Silent	SNP	C	G	G			TCGA-32-2638-01	TCGA-32-2638-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:69199951C>G	uc004dxu.1	+	c.852C>G	c.(850-852)CTC>CTG	p.L284L		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	284											0														1	51.300627	51.300504	13	0	CC		KEEP	---	---	---	---	capture			Silent	SNP	69199951	69199951	11729	23	C	G	G	30	30	OTUD6A	G	3	3
XPO4	64328	broad.mit.edu	36	13	20260729	20260729	+	Frame_Shift_Del	DEL	G	-	-			TCGA-32-2638-01	TCGA-32-2638-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:20260729_20260729delG	uc001unq.2	-	c.2943_2943delC	c.(2941-2943)TACfs	p.Y981fs		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	981					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)						353				0.34			45	86				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	20260729	20260729	18029	13	G	-	-	48	48	XPO4	-	5	5
FRK	2444	broad.mit.edu	36	6	116372132	116372132	+	Frame_Shift_Del	DEL	C	-	-			TCGA-32-2638-01	TCGA-32-2638-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:116372132_116372132delC	uc003pwi.1	-	c.1108_1108delG	c.(1108-1110)GTAfs	p.V370fs		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	370	Protein kinase.				negative regulation of cell proliferation|protein phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)						355				0.36			53	95				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	116372132	116372132	6298	6	C	-	-	20	20	FRK	-	5	5
