Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
NT5C2	22978	broad.mit.edu	37	10	104850489	104850489	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:104850489C>T	uc001kwo.2	-	c.1328G>A	c.(1327-1329)AGT>AAT	p.S443N	NT5C2_uc010qqp.1_Missense_Mutation_p.S414N|NT5C2_uc001kwq.2_Missense_Mutation_p.S443N|NT5C2_uc001kwp.2_Missense_Mutation_p.S290N	NM_012229	NP_036361	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	443					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding				0		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)									0.343284	66.703664	68.157764	23	44	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	104850489	104850489	11092	10	C	T	T	T	260	20	NT5C2	2	2
C10orf90	118611	broad.mit.edu	37	10	128114599	128114599	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:128114599G>A	uc010qum.1	-	c.2313C>T	c.(2311-2313)ATC>ATT	p.I771I	C10orf90_uc001ljp.2_Silent_p.I530I|C10orf90_uc001ljq.2_Silent_p.I674I|C10orf90_uc001ljo.2_Non-coding_Transcript	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	674											0		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)										0.321586	207.293451	213.712005	73	154	KEEP	---	---	---	---	capture		Silent	SNP	128114599	128114599	1660	10	G	A	A	A	421	33	C10orf90	2	2
FRMPD2	143162	broad.mit.edu	37	10	49440183	49440183	+	Silent	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:49440183G>C	uc001jgi.2	-	c.1143C>G	c.(1141-1143)ACC>ACG	p.T381T	FRMPD2_uc001jgh.2_Silent_p.T350T|FRMPD2_uc001jgj.2_Silent_p.T359T	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	381	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)										0.367521	136.325661	138.156848	43	74	KEEP	---	---	---	---	capture		Silent	SNP	49440183	49440183	6308	10	G	C	C	C	444	35	FRMPD2	3	3
STOX1	219736	broad.mit.edu	37	10	70644771	70644771	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:70644771C>G	uc001jos.2	+	c.1219C>G	c.(1219-1221)CCT>GCT	p.P407A	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.P297A	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	407						cytoplasm|nucleolus	DNA binding			kidney(1)	1														0.375887	375.942427	379.768137	106	176	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	70644771	70644771	15839	10	C	G	G	G	390	30	STOX1	3	3
STOX1	219736	broad.mit.edu	37	10	70645178	70645178	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:70645178C>G	uc001jos.2	+	c.1626C>G	c.(1624-1626)ATC>ATG	p.I542M	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.I432M	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	542						cytoplasm|nucleolus	DNA binding			kidney(1)	1														0.409091	129.881892	130.517792	36	52	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	70645178	70645178	15839	10	C	G	G	G	408	32	STOX1	3	3
P4HA1	5033	broad.mit.edu	37	10	74804763	74804763	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:74804763G>A	uc010qka.1	-	c.1124C>T	c.(1123-1125)ACG>ATG	p.T375M	P4HA1_uc001jtg.2_Missense_Mutation_p.T375M|P4HA1_uc001jth.2_Intron|P4HA1_uc010qkb.1_Intron|P4HA1_uc001jti.2_Intron	NM_001142595	NP_001136067	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha I subunit isoform 2	375					oxidation-reduction process	endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	Colon(147;367 2405 2662 52127)								0.35	101.994925	103.980103	35	65	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	74804763	74804763	11769	10	G	A	A	A	520	40	P4HA1	1	1
NNMT	4837	broad.mit.edu	37	11	114167355	114167355	+	Missense_Mutation	SNP	A	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:114167355A>G	uc001por.1	+	c.77A>G	c.(76-78)AAG>AGG	p.K26R	NNMT_uc001pos.1_Missense_Mutation_p.K26R	NM_006169	NP_006160	P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	26					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			ovary(1)	1		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)									0.314815	114.512815	117.806815	34	74	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	114167355	114167355	10912	11	A	G	G	G	39	3	NNMT	4	4
ADAMTS15	170689	broad.mit.edu	37	11	130319634	130319634	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:130319634C>T	uc010scd.1	+	c.766C>T	c.(766-768)CCC>TCC	p.P256S		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	256	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|lung(1)|pancreas(1)	4	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)								OREG0021518	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.357143	26.842416	27.345563	10	18	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	130319634	130319634	261	11	C	T	T	T	390	30	ADAMTS15	2	2
OPCML	4978	broad.mit.edu	37	11	132306577	132306577	+	Missense_Mutation	SNP	A	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:132306577A>G	uc010sck.1	-	c.761T>C	c.(760-762)TTC>TCC	p.F254S	OPCML_uc001qgu.2_Missense_Mutation_p.F247S|OPCML_uc001qgs.2_Missense_Mutation_p.F254S|OPCML_uc001qgt.2_Missense_Mutation_p.F253S|OPCML_uc010scl.1_Missense_Mutation_p.F213S	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	254	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)	2	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)										0.311111	91.768708	94.627366	28	62	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	132306577	132306577	11280	11	A	G	G	G	117	9	OPCML	4	4
MRGPRX4	117196	broad.mit.edu	37	11	18195626	18195626	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:18195626G>A	uc001mnv.1	+	c.823G>A	c.(823-825)GTG>ATG	p.V275M		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	275	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0														0.420513	247.356124	248.420769	82	113	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	18195626	18195626	10162	11	G	A	A	A	520	40	MRGPRX4	1	1
CAPRIN1	4076	broad.mit.edu	37	11	34113552	34113552	+	Nonsense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:34113552C>T	uc001mvh.1	+	c.1654C>T	c.(1654-1656)CAG>TAG	p.Q552*	CAPRIN1_uc001mvg.2_Nonsense_Mutation_p.Q552*|CAPRIN1_uc001mvi.2_Nonsense_Mutation_p.Q552*|CAPRIN1_uc001mvj.1_Nonsense_Mutation_p.Q471*	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	membrane component chromosome 11 surface marker	552					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)												0.320513	66.840097	69.076472	25	53	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	34113552	34113552	2754	11	C	T	T	T	377	29	CAPRIN1	5	2
SPRYD5	84767	broad.mit.edu	37	11	55655667	55655667	+	Silent	SNP	A	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:55655667A>C	uc010rip.1	+	c.667A>C	c.(667-669)AGG>CGG	p.R223R	SPRYD5_uc010riq.1_Silent_p.R80R	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	223						intracellular	zinc ion binding				0		all_epithelial(135;0.226)												0.310811	69.588694	71.9532	23	51	KEEP	---	---	---	---	capture		Silent	SNP	55655667	55655667	15625	11	A	C	C	C	88	7	SPRYD5	4	4
LPXN	9404	broad.mit.edu	37	11	58317464	58317464	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:58317464G>A	uc010rkj.1	-	c.657C>T	c.(655-657)TGC>TGT	p.C219C	LPXN_uc001nmw.2_Silent_p.C214C|LPXN_uc009ymp.2_Silent_p.C84C|LPXN_uc010rkk.1_Silent_p.C194C	NM_001143995	NP_001137467	O60711	LPXN_HUMAN	leupaxin isoform 1	214	LIM zinc-binding 2.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)												0.354839	157.188061	160.063066	55	100	KEEP	---	---	---	---	capture		Silent	SNP	58317464	58317464	9302	11	G	A	A	A	490	38	LPXN	1	1
STIP1	10963	broad.mit.edu	37	11	63967504	63967504	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:63967504G>A	uc001nyk.1	+	c.1116G>A	c.(1114-1116)CAG>CAA	p.Q372Q	STIP1_uc010rnb.1_Silent_p.Q348Q	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	372	TPR 7.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3														0.136364	48.08957	76.26724	30	190	KEEP	---	---	---	---	capture		Silent	SNP	63967504	63967504	15805	11	G	A	A	A	425	33	STIP1	2	2
STIP1	10963	broad.mit.edu	37	11	63971036	63971036	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:63971036G>A	uc001nyk.1	+	c.1501G>A	c.(1501-1503)GAC>AAC	p.D501N	STIP1_uc010rnb.1_Missense_Mutation_p.D477N	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	501	STI1 2.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3														0.149606	27.84318	42.799185	19	108	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	63971036	63971036	15805	11	G	A	A	A	585	45	STIP1	2	2
RASAL1	8437	broad.mit.edu	37	12	113559367	113559367	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:113559367C>G	uc001tun.1	-	c.375G>C	c.(373-375)CAG>CAC	p.Q125H	RASAL1_uc010syp.1_Missense_Mutation_p.Q125H|RASAL1_uc001tul.2_Missense_Mutation_p.Q125H|RASAL1_uc001tum.1_Missense_Mutation_p.Q125H|RASAL1_uc010syq.1_Missense_Mutation_p.Q125H|RASAL1_uc001tuo.3_Missense_Mutation_p.Q125H|RASAL1_uc010syr.1_Missense_Mutation_p.Q125H	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	125	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(1)	3														0.348148	154.383807	157.131591	47	88	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	113559367	113559367	13524	12	C	G	G	G	415	32	RASAL1	3	3
ITPR2	3709	broad.mit.edu	37	12	26775203	26775203	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:26775203C>T	uc001rhg.2	-	c.3258G>A	c.(3256-3258)CAG>CAA	p.Q1086Q		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1086	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	13	Colorectal(261;0.0847)									1600				0.5	70.84736	70.84736	22	22	KEEP	---	---	---	---	capture		Silent	SNP	26775203	26775203	8225	12	C	T	T	T	415	32	ITPR2	2	2
GTSF1	121355	broad.mit.edu	37	12	54858851	54858851	+	Missense_Mutation	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:54858851C>A	uc001sgb.2	-	c.117G>T	c.(115-117)AAG>AAT	p.K39N		NM_144594	NP_653195	Q8WW33	GTSF1_HUMAN	gametocyte specific factor 1	39							metal ion binding				0		Myeloproliferative disorder(1001;0.00452)												0.415254	147.248141	147.989454	49	69	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	54858851	54858851	7166	12	C	A	A	A	311	24	GTSF1	2	2
NEUROD4	58158	broad.mit.edu	37	12	55420633	55420633	+	Nonsense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:55420633G>A	uc001sgp.3	+	c.410G>A	c.(409-411)TGG>TAG	p.W137*		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	137	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription regulator activity			ovary(3)	3														0.327273	102.257356	105.170548	36	74	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	55420633	55420633	10750	12	G	A	A	A	611	47	NEUROD4	5	2
OR9K2	441639	broad.mit.edu	37	12	55524128	55524128	+	Silent	SNP	T	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:55524128T>G	uc010spe.1	+	c.576T>G	c.(574-576)TCT>TCG	p.S192S		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2														0.42735	166.838534	167.375553	50	67	KEEP	---	---	---	---	capture		Silent	SNP	55524128	55524128	11665	12	T	G	G	G	717	56	OR9K2	4	4
NACA	4666	broad.mit.edu	37	12	57111976	57111976	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:57111976G>A	uc009zoy.1	-	c.3338C>T	c.(3337-3339)CCA>CTA	p.P1113L	NACA_uc001slz.2_Intron|NACA_uc001sly.2_Intron|NACA_uc001smc.2_Intron|NACA_uc001sma.2_Intron|NACA_uc001smb.2_Intron|NACA_uc010squ.1_Intron	NM_001113203	NP_001106674	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	Error:Variant_position_missing_in_Q13765_after_alignment					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1										449				0.460526	205.303232	205.510915	70	82	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57111976	57111976	10528	12	G	A	A	A	611	47	NACA	2	2
CD163	9332	broad.mit.edu	37	12	7649601	7649601	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:7649601C>T	uc001qsz.3	-	c.907G>A	c.(907-909)GCA>ACA	p.A303T	CD163_uc001qta.3_Missense_Mutation_p.A303T|CD163_uc009zfw.2_Missense_Mutation_p.A303T	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	303	SRCR 3.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8														0.408451	77.941323	78.465976	29	42	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	7649601	7649601	3094	12	C	T	T	T	338	26	CD163	2	2
DUSP6	1848	broad.mit.edu	37	12	89743225	89743225	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:89743225C>G	uc001tay.2	-	c.952G>C	c.(952-954)GAT>CAT	p.D318H	DUSP6_uc001taz.2_Missense_Mutation_p.D172H	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	318	Tyrosine-protein phosphatase.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						Colon(132;3456 5224)				159				0.350282	202.593778	206.095345	62	115	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	89743225	89743225	5014	12	C	G	G	G	403	31	DUSP6	3	3
LATS2	26524	broad.mit.edu	37	13	21562678	21562678	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:21562678G>A	uc009zzs.2	-	c.1241C>T	c.(1240-1242)CCG>CTG	p.P414L	LATS2_uc001unr.3_Missense_Mutation_p.P414L	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	414					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|protein phosphorylation	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|pancreas(1)	9		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)						174				0.5	16.275038	16.275038	5	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	21562678	21562678	8970	13	G	A	A	A	507	39	LATS2	1	1
FNDC3A	22862	broad.mit.edu	37	13	49712888	49712888	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:49712888G>C	uc001vcm.2	+	c.766G>C	c.(766-768)GAT>CAT	p.D256H	FNDC3A_uc001vcl.1_Missense_Mutation_p.D256H|FNDC3A_uc001vcn.2_Missense_Mutation_p.D256H|FNDC3A_uc001vco.2_Non-coding_Transcript|FNDC3A_uc001vcp.1_Missense_Mutation_p.D200H|FNDC3A_uc001vcq.2_Missense_Mutation_p.D200H	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	256						Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)										0.428571	20.447982	20.510282	6	8	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	49712888	49712888	6211	13	G	C	C	C	429	33	FNDC3A	3	3
PCDH17	27253	broad.mit.edu	37	13	58299337	58299337	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:58299337G>C	uc001vhq.1	+	c.3389G>C	c.(3388-3390)AGA>ACA	p.R1130T	PCDH17_uc010aec.1_Missense_Mutation_p.R1129T|PCDH17_uc001vhr.1_Missense_Mutation_p.R219T	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1130	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(2)|pancreas(2)	4		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		Melanoma(72;952 1291 1619 12849 33676)								0.333333	399.58243	408.205152	117	234	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	58299337	58299337	11932	13	G	C	C	C	429	33	PCDH17	3	3
GPC6	10082	broad.mit.edu	37	13	95050858	95050858	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:95050858C>T	uc001vlt.2	+	c.1428C>T	c.(1426-1428)AAC>AAT	p.N476N		NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	476						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)												0.428571	114.407162	114.811868	39	52	KEEP	---	---	---	---	capture		Silent	SNP	95050858	95050858	6876	13	C	T	T	T	246	19	GPC6	1	1
AHNAK2	113146	broad.mit.edu	37	14	105418953	105418953	+	Silent	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:105418953C>G	uc010axc.1	-	c.2835G>C	c.(2833-2835)CTG>CTC	p.L945L	AHNAK2_uc001ypx.2_Silent_p.L845L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	945						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)											0.242259	408.201937	441.453417	133	416	KEEP	---	---	---	---	capture		Silent	SNP	105418953	105418953	418	14	C	G	G	G	366	29	AHNAK2	3	3
AHNAK2	113146	broad.mit.edu	37	14	105419198	105419198	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:105419198C>G	uc010axc.1	-	c.2590G>C	c.(2590-2592)GAG>CAG	p.E864Q	AHNAK2_uc001ypx.2_Missense_Mutation_p.E764Q	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	864						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)											0.144208	112.310884	163.855832	61	362	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	105419198	105419198	418	14	C	G	G	G	390	30	AHNAK2	3	3
NFATC4	4776	broad.mit.edu	37	14	24843028	24843028	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:24843028G>A	uc010tol.1	+	c.1876G>A	c.(1876-1878)GGG>AGG	p.G626R	NFATC4_uc010tok.1_Missense_Mutation_p.G626R|NFATC4_uc010alr.2_Missense_Mutation_p.G626R|NFATC4_uc010als.2_Missense_Mutation_p.G576R|NFATC4_uc010tom.1_Missense_Mutation_p.G576R|NFATC4_uc010ton.1_Missense_Mutation_p.G576R|NFATC4_uc010too.1_Missense_Mutation_p.G576R|NFATC4_uc010alt.2_Missense_Mutation_p.G595R|NFATC4_uc010top.1_Missense_Mutation_p.G595R|NFATC4_uc010toq.1_Missense_Mutation_p.G595R|NFATC4_uc010alu.2_Missense_Mutation_p.G255R|NFATC4_uc001wpc.2_Missense_Mutation_p.G563R|NFATC4_uc010tor.1_Missense_Mutation_p.G563R|NFATC4_uc010tos.1_Missense_Mutation_p.G493R|NFATC4_uc010tot.1_Missense_Mutation_p.G551R|NFATC4_uc010tou.1_Missense_Mutation_p.G493R|NFATC4_uc010tov.1_Missense_Mutation_p.G551R|NFATC4_uc010tow.1_Missense_Mutation_p.G493R|NFATC4_uc010alv.2_Missense_Mutation_p.G551R|NFATC4_uc010tox.1_Missense_Mutation_p.G493R|NFATC4_uc001wpd.2_Missense_Mutation_p.G98R|NFATC4_uc010toy.1_Missense_Mutation_p.G98R|NFATC4_uc010toz.1_Missense_Mutation_p.G98R|NFATC4_uc010tpa.1_5'UTR|NFATC4_uc010tpb.1_5'UTR	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	563	RHD.				cell differentiation|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(265;0.018)										0.258503	101.436413	109.170527	38	109	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	24843028	24843028	10765	14	G	A	A	A	507	39	NFATC4	1	1
MIA2	117153	broad.mit.edu	37	14	39717345	39717345	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:39717345G>C	uc001wux.2	+	c.1567G>C	c.(1567-1569)GAT>CAT	p.D523H	MIA2_uc010amy.1_Missense_Mutation_p.G454R	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	523						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)										0.263889	48.38882	52.020404	19	53	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	39717345	39717345	9954	14	G	C	C	C	455	35	MIA2	3	3
GPR139	124274	broad.mit.edu	37	16	20043946	20043946	+	Missense_Mutation	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:20043946C>A	uc002dgu.1	-	c.173G>T	c.(172-174)AGA>ATA	p.R58I	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	58	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2														0.333333	53.076833	54.554454	20	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20043946	20043946	6922	16	C	A	A	A	416	32	GPR139	2	2
TMEM8A	58986	broad.mit.edu	37	16	424341	424341	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:424341C>G	uc002cgu.3	-	c.1635G>C	c.(1633-1635)AGG>AGC	p.R545S	TMEM8A_uc002cgv.3_Missense_Mutation_p.R352S	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	545	Extracellular (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3												OREG0003702	type=REGULATORY REGION|Gene=TMEM8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0.388889	43.642105	44.031314	14	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	424341	424341	16754	16	C	G	G	G	285	22	TMEM8A	3	3
SHCBP1	79801	broad.mit.edu	37	16	46629580	46629580	+	Missense_Mutation	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:46629580C>A	uc002eec.3	-	c.1348G>T	c.(1348-1350)GTT>TTT	p.V450F		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	450	PbH1 1.			V -> A (in Ref. 1; BAB15208).						ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)												0.352941	85.522533	87.144452	30	55	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	46629580	46629580	14766	16	C	A	A	A	221	17	SHCBP1	2	2
EXOC3L	283849	broad.mit.edu	37	16	67220984	67220984	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:67220984C>G	uc002erx.1	-	c.1098G>C	c.(1096-1098)GAG>GAC	p.E366D	EXOC3L_uc002erv.1_Non-coding_Transcript|EXOC3L_uc002erw.1_Missense_Mutation_p.E17D|EXOC3L_uc002ery.1_Missense_Mutation_p.E310D|EXOC3L_uc010vje.1_Missense_Mutation_p.E305D	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	366	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)										0.350254	205.925689	209.817965	69	128	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	67220984	67220984	5497	16	C	G	G	G	363	28	EXOC3L	3	3
TOP3A	7156	broad.mit.edu	37	17	18208473	18208473	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:18208473C>G	uc002gsx.1	-	c.452G>C	c.(451-453)AGA>ACA	p.R151T	TOP3A_uc002gsw.1_5'UTR|TOP3A_uc010vxs.1_Missense_Mutation_p.R49T|TOP3A_uc010cqa.1_Non-coding_Transcript	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	151	Toprim.				DNA topological change|DNA unwinding involved in replication|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(2)	2														0.203125	106.313864	122.027976	39	153	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	18208473	18208473	16909	17	C	G	G	G	416	32	TOP3A	3	3
TSR1	55720	broad.mit.edu	37	17	2232642	2232642	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:2232642G>C	uc002fuj.2	-	c.1898C>G	c.(1897-1899)ACT>AGT	p.T633S	SNORD91B_uc002fuk.1_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	633					ribosome assembly	nucleolus	protein binding			ovary(1)	1														0.523077	126.483909	126.516789	34	31	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	2232642	2232642	17217	17	G	C	C	C	468	36	TSR1	3	3
RFFL	117584	broad.mit.edu	37	17	33343556	33343556	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:33343556G>C	uc010cti.1	-	c.737C>G	c.(736-738)TCT>TGT	p.S246C	RFFL_uc002hiq.2_Missense_Mutation_p.S157C|RFFL_uc002him.1_Missense_Mutation_p.S240C|RFFL_uc002hin.1_Missense_Mutation_p.S240C|RFFL_uc002hip.1_Missense_Mutation_p.S212C|RFFL_uc002hio.1_Missense_Mutation_p.S240C	NM_057178	NP_476519	Q8WZ73	RFFL_HUMAN	rififylin	240					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)										0.358333	147.412852	149.52469	43	77	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	33343556	33343556	13721	17	G	C	C	C	429	33	RFFL	3	3
KLHL10	317719	broad.mit.edu	37	17	39998143	39998143	+	Missense_Mutation	SNP	A	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:39998143A>T	uc010cxr.2	+	c.263A>T	c.(262-264)GAC>GTC	p.D88V	KLHL10_uc010wfv.1_Missense_Mutation_p.D82V|KLHL10_uc010wfw.1_5'UTR	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	kelch-like 10	88	BTB.					cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)												0.520548	114.253117	114.280333	38	35	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	39998143	39998143	8678	17	A	T	T	T	130	10	KLHL10	3	3
ARHGAP27	201176	broad.mit.edu	37	17	43481669	43481669	+	Nonsense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:43481669C>T	uc002iix.2	-	c.422G>A	c.(421-423)TGG>TAG	p.W141*	ARHGAP27_uc010dak.2_Nonsense_Mutation_p.W114*|ARHGAP27_uc010wjl.1_Intron	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	482					positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)													0.276596	62.200543	66.430565	26	68	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	43481669	43481669	888	17	C	T	T	T	273	21	ARHGAP27	5	2
CACNG4	27092	broad.mit.edu	37	17	64961111	64961111	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:64961111C>T	uc002jft.1	+	c.84C>T	c.(82-84)ATC>ATT	p.I28I		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	28	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)											0.478261	30.492676	30.503595	11	12	KEEP	---	---	---	---	capture		Silent	SNP	64961111	64961111	2675	17	C	T	T	T	395	31	CACNG4	1	1
HELZ	9931	broad.mit.edu	37	17	65190134	65190134	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:65190134C>T	uc010wqk.1	-	c.506G>A	c.(505-507)CGC>CAC	p.R169H	HELZ_uc002jfv.3_Non-coding_Transcript|HELZ_uc002jfx.3_Missense_Mutation_p.R169H	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)													0.357143	13.170018	13.422042	5	9	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	65190134	65190134	7332	17	C	T	T	T	351	27	HELZ	1	1
TP53	7157	broad.mit.edu	37	17	7578535	7578535	+	Missense_Mutation	SNP	T	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:7578535T>C	uc002gim.2	-	c.395A>G	c.(394-396)AAG>AGG	p.K132R	TP53_uc002gig.1_Missense_Mutation_p.K132R|TP53_uc002gih.2_Missense_Mutation_p.K132R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.K132R|TP53_uc010cni.1_Missense_Mutation_p.K132R|TP53_uc002gij.2_Missense_Mutation_p.K132R|TP53_uc010cnj.1_Non-coding_Transcript|TP53_uc002gin.2_Missense_Mutation_p.K39R|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.K93R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	132	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> T (in sporadic cancers; somatic mutation).|KM -> NL (in a sporadic cancer; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> Q (in sporadic cancers; somatic mutation).|K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.K132R(31)|p.K132M(8)|p.0?(6)|p.Y126_K132delYSPALNK(6)|p.K132T(3)|p.N131del(2)|p.N131fs*27(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.A129_K132delALNK(1)|p.Y126fs*11(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.L130_M133delLNKM(1)|p.K132W(1)|p.K132E(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		Pancreas(47;798 1329 9957 10801)		111	p.K132T(SNU81-Tumor)|p.K132R(RI1-Tumor)|p.K132R(KU812-Tumor)	690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.588235	115.587282	115.94512	30	21	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	7578535	7578535	16923	17	T	C	C	C	728	56	TP53	4	4
FOXK2	3607	broad.mit.edu	37	17	80545103	80545103	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:80545103C>T	uc002kfn.2	+	c.1741C>T	c.(1741-1743)CAC>TAC	p.H581Y	FOXK2_uc002kfm.1_Missense_Mutation_p.H581Y|FOXK2_uc010diu.2_Intron	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	581					embryo development|negative regulation of gene-specific transcription from RNA polymerase II promoter|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)											0.336957	79.881533	82.052148	31	61	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	80545103	80545103	6261	17	C	T	T	T	377	29	FOXK2	2	2
ATP8B3	148229	broad.mit.edu	37	19	1800443	1800443	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:1800443G>A	uc002ltw.2	-	c.1158C>T	c.(1156-1158)TTC>TTT	p.F386F	ATP8B3_uc002ltv.2_Silent_p.F339F|ATP8B3_uc002ltx.2_Non-coding_Transcript|ATP8B3_uc002lty.1_Silent_p.F134F|ATP8B3_uc002ltz.1_Silent_p.F333F	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	386	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)										0.536585	135.692177	135.786565	44	38	KEEP	---	---	---	---	capture		Silent	SNP	1800443	1800443	1215	19	G	A	A	A	581	45	ATP8B3	2	2
GATAD2A	54815	broad.mit.edu	37	19	19612198	19612198	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:19612198C>T	uc010xqv.1	+	c.1533C>T	c.(1531-1533)ACC>ACT	p.T511T	GATAD2A_uc010xqt.1_Silent_p.T491T|GATAD2A_uc010xqu.1_Silent_p.T120T|GATAD2A_uc010xqw.1_Silent_p.T319T	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	491					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription repressor activity|zinc ion binding				0														0.333333	19.318023	19.834625	7	14	KEEP	---	---	---	---	capture		Silent	SNP	19612198	19612198	6524	19	C	T	T	T	288	23	GATAD2A	1	1
ZNF556	80032	broad.mit.edu	37	19	2877779	2877779	+	Nonsense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:2877779C>T	uc002lwp.1	+	c.823C>T	c.(823-825)CGA>TGA	p.R275*	ZNF556_uc002lwq.2_Nonsense_Mutation_p.R274*	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	275	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)										0.553191	80.752714	80.868258	26	21	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	2877779	2877779	18582	19	C	T	T	T	399	31	ZNF556	5	1
SLC25A23	79085	broad.mit.edu	37	19	6454687	6454687	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:6454687G>A	uc002mex.1	-	c.525C>T	c.(523-525)TTC>TTT	p.F175F	SLC25A23_uc002mev.2_Non-coding_Transcript|SLC25A23_uc010xjd.1_5'UTR	NM_024103	NP_077008	Q9BV35	SCMC3_HUMAN	solute carrier family 25, member 23	175	Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)|pancreas(1)	2														0.674419	98.38904	99.549979	29	14	KEEP	---	---	---	---	capture		Silent	SNP	6454687	6454687	14983	19	G	A	A	A	425	33	SLC25A23	2	2
MFN2	9927	broad.mit.edu	37	1	12064925	12064925	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:12064925C>G	uc001atn.3	+	c.1436C>G	c.(1435-1437)TCT>TGT	p.S479C	MFN2_uc009vni.2_Missense_Mutation_p.S479C	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	479	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)										0.363636	50.988734	51.708273	16	28	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	12064925	12064925	9914	1	C	G	G	G	416	32	MFN2	3	3
PKLR	5313	broad.mit.edu	37	1	155270024	155270024	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:155270024C>T	uc001fkb.3	-	c.148G>A	c.(148-150)GAG>AAG	p.E50K	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.E19K|PKLR_uc010pga.1_Intron	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	50			Missing (in PKRD).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(3)|ovary(1)	4	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)									0.416667	28.443763	28.58972	10	14	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	155270024	155270024	12401	1	C	T	T	T	390	30	PKLR	2	2
KIAA0907	22889	broad.mit.edu	37	1	155886524	155886524	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:155886524C>T	uc001fmi.1	-	c.1445G>A	c.(1444-1446)GGA>GAA	p.G482E	KIAA0907_uc001fmj.1_Missense_Mutation_p.G482E|KIAA0907_uc009wrk.1_Missense_Mutation_p.G339E|KIAA0907_uc009wrl.1_Non-coding_Transcript	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	482											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)											0.137056	81.995861	132.246254	54	340	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	155886524	155886524	8506	1	C	T	T	T	390	30	KIAA0907	2	2
SPEN	23013	broad.mit.edu	37	1	16258747	16258747	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:16258747G>A	uc001axk.1	+	c.6012G>A	c.(6010-6012)CCG>CCA	p.P2004P	SPEN_uc010obp.1_Silent_p.P1963P	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2004					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	14		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)					p.P2004P(NCIH1436-Tumor)	551				0.211111	43.319974	50.235006	19	71	KEEP	---	---	---	---	capture		Silent	SNP	16258747	16258747	15550	1	G	A	A	A	470	37	SPEN	1	1
ASPM	259266	broad.mit.edu	37	1	197074232	197074232	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:197074232C>T	uc001gtu.2	-	c.4149G>A	c.(4147-4149)ATG>ATA	p.M1383I	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1383					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6														0.12963	7.781642	15.006115	7	47	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	197074232	197074232	1075	1	C	T	T	T	377	29	ASPM	2	2
C1orf115	79762	broad.mit.edu	37	1	220870013	220870013	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:220870013C>T	uc001hmp.1	+	c.369C>T	c.(367-369)TTC>TTT	p.F123F		NM_024709	NP_078985	Q9H7X2	CA115_HUMAN	hypothetical protein LOC79762	123	Helical; (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0273)										0.339623	143.913257	147.522744	54	105	KEEP	---	---	---	---	capture		Silent	SNP	220870013	220870013	2055	1	C	T	T	T	402	31	C1orf115	1	1
RYR2	6262	broad.mit.edu	37	1	237936919	237936919	+	Missense_Mutation	SNP	G	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:237936919G>T	uc001hyl.1	+	c.11746G>T	c.(11746-11748)GTC>TTC	p.V3916F	RYR2_uc010pya.1_Missense_Mutation_p.V331F	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3916					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)											0.470588	25.098512	25.111333	8	9	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	237936919	237936919	14249	1	G	T	T	T	468	36	RYR2	2	2
ZYG11B	79699	broad.mit.edu	37	1	53236866	53236866	+	Missense_Mutation	SNP	T	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:53236866T>G	uc001cuj.2	+	c.371T>G	c.(370-372)ATT>AGT	p.I124S	ZYG11B_uc009vzg.2_Non-coding_Transcript|ZYG11B_uc010onj.1_Missense_Mutation_p.I115S	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	124							protein binding			ovary(1)|pancreas(1)	2														0.468468	188.398331	188.493798	52	59	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	53236866	53236866	18859	1	T	G	G	G	676	52	ZYG11B	4	4
KANK4	163782	broad.mit.edu	37	1	62738935	62738935	+	Missense_Mutation	SNP	T	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:62738935T>A	uc001dah.3	-	c.1841A>T	c.(1840-1842)TAC>TTC	p.Y614F	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	614										ovary(3)|lung(1)	4														0.264706	42.948378	46.333381	18	50	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	62738935	62738935	8283	1	T	A	A	A	741	57	KANK4	3	3
MKKS	8195	broad.mit.edu	37	20	10394084	10394084	+	Missense_Mutation	SNP	A	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:10394084A>C	uc002wnt.1	-	c.79T>G	c.(79-81)TCT>GCT	p.S27A	MKKS_uc002wnu.1_Missense_Mutation_p.S27A|MKKS_uc010zrd.1_Intron	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	27					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						Melanoma(79;1979 2212 6640)								0.505435	337.695978	337.699816	93	91	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10394084	10394084	9990	20	A	C	C	C	117	9	MKKS	4	4
RRBP1	6238	broad.mit.edu	37	20	17616230	17616230	+	Missense_Mutation	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:17616230C>A	uc002wpv.1	-	c.1118G>T	c.(1117-1119)CGG>CTG	p.R373L	RRBP1_uc002wpu.2_Missense_Mutation_p.R147L|RRBP1_uc002wpw.1_Missense_Mutation_p.R373L|RRBP1_uc010gcl.1_Missense_Mutation_p.R147L|RRBP1_uc010gcm.1_5'UTR	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	806	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1														0.171717	31.921833	42.002845	17	82	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	17616230	17616230	14158	20	C	A	A	A	299	23	RRBP1	1	1
ACSS1	84532	broad.mit.edu	37	20	24994617	24994617	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:24994617G>A	uc002wub.2	-	c.1432C>T	c.(1432-1434)CCC>TCC	p.P478S	ACSS1_uc002wuc.2_Missense_Mutation_p.P476S|ACSS1_uc010gdc.2_Missense_Mutation_p.P273S|ACSS1_uc002wud.1_Non-coding_Transcript|ACSS1_uc002wua.2_Missense_Mutation_p.P395S	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	478					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)									0.235294	31.795267	35.0486	12	39	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	24994617	24994617	189	20	G	A	A	A	559	43	ACSS1	2	2
CDS2	8760	broad.mit.edu	37	20	5170850	5170850	+	Silent	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:5170850G>C	uc002wls.2	+	c.1308G>C	c.(1306-1308)GGG>GGC	p.G436G	CDS2_uc010zqt.1_Non-coding_Transcript|CDS2_uc002wlu.2_3'UTR|CDS2_uc010zqu.1_Silent_p.G316G|CDS2_uc002wlv.2_Silent_p.G338G|CDS2_uc010zqv.1_Silent_p.G206G	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	436					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0														0.180556	35.132848	42.037858	13	59	KEEP	---	---	---	---	capture		Silent	SNP	5170850	5170850	3307	20	G	C	C	C	522	41	CDS2	3	3
C20orf177	63939	broad.mit.edu	37	20	58519680	58519680	+	Missense_Mutation	SNP	G	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:58519680G>T	uc002yba.2	+	c.682G>T	c.(682-684)GCT>TCT	p.A228S	C20orf177_uc010zzx.1_Missense_Mutation_p.A71S|C20orf177_uc002ybc.2_Missense_Mutation_p.A228S	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	228										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)											0.375	108.99111	110.420729	39	65	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	58519680	58519680	2174	20	G	T	T	T	598	46	C20orf177	2	2
TRMT6	51605	broad.mit.edu	37	20	5921732	5921732	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:5921732G>A	uc002wmh.1	-	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	TRMT6_uc010zra.1_Silent_p.L253L	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	423					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1														0.381703	331.729487	335.642701	121	196	KEEP	---	---	---	---	capture		Silent	SNP	5921732	5921732	17118	20	G	A	A	A	574	45	TRMT6	2	2
CABIN1	23523	broad.mit.edu	37	22	24451495	24451495	+	Silent	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:24451495C>A	uc002zzi.1	+	c.966C>A	c.(964-966)ATC>ATA	p.I322I	CABIN1_uc002zzj.1_Silent_p.I272I|CABIN1_uc002zzl.1_Silent_p.I322I|CABIN1_uc010guk.1_Silent_p.I277I|CABIN1_uc002zzk.1_Silent_p.I277I	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	322					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4														0.319149	73.596272	76.34001	30	64	KEEP	---	---	---	---	capture		Silent	SNP	24451495	24451495	2644	22	C	A	A	A	382	30	CABIN1	2	2
ADRBK2	157	broad.mit.edu	37	22	26118409	26118409	+	Missense_Mutation	SNP	G	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:26118409G>T	uc003abx.3	+	c.2059G>T	c.(2059-2061)GGC>TGC	p.G687C	ADRBK2_uc003aby.3_Non-coding_Transcript	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	687					protein phosphorylation		ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)	5					Adenosine triphosphate(DB00171)				p.G687S(OVTOKO-Tumor)	345				0.1875	18.145148	22.536748	9	39	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	26118409	26118409	345	22	G	T	T	T	507	39	ADRBK2	1	1
MEI1	150365	broad.mit.edu	37	22	42099416	42099416	+	Nonsense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:42099416C>T	uc003baz.1	+	c.256C>T	c.(256-258)CAG>TAG	p.Q86*	MEI1_uc003bay.3_Nonsense_Mutation_p.Q86*|MEI1_uc011apd.1_Non-coding_Transcript	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	86							binding			skin(1)	1														0.4	22.79467	22.969954	8	12	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	42099416	42099416	9854	22	C	T	T	T	377	29	MEI1	5	2
CCNT2	905	broad.mit.edu	37	2	135710263	135710263	+	Missense_Mutation	SNP	G	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:135710263G>T	uc002tuc.1	+	c.756G>T	c.(754-756)AAG>AAT	p.K252N	CCNT2_uc002tub.1_Missense_Mutation_p.K252N|CCNT2_uc010zbf.1_Missense_Mutation_p.K77N|CCNT2_uc002tud.1_5'UTR	NM_058241	NP_490595	O60583	CCNT2_HUMAN	cyclin T2 isoform b	252					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				ovary(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.107)										0.229508	32.023909	36.112677	14	47	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	135710263	135710263	3062	2	G	T	T	T	425	33	CCNT2	2	2
XIRP2	129446	broad.mit.edu	37	2	168100783	168100783	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:168100783G>A	uc002udx.2	+	c.2881G>A	c.(2881-2883)GAT>AAT	p.D961N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D786N|XIRP2_uc010fpq.2_Missense_Mutation_p.D739N|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	786					actin cytoskeleton organization	cell junction	actin binding			ovary(6)|pancreas(1)|skin(1)	8														0.354839	89.940625	91.671	33	60	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	168100783	168100783	18011	2	G	A	A	A	585	45	XIRP2	2	2
SDPR	8436	broad.mit.edu	37	2	192711260	192711260	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:192711260C>T	uc002utb.2	-	c.392G>A	c.(391-393)CGC>CAC	p.R131H		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	131	Potential.					caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)									0.284404	76.773288	81.326664	31	78	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	192711260	192711260	14456	2	C	T	T	T	351	27	SDPR	1	1
ACSL3	2181	broad.mit.edu	37	2	223786028	223786028	+	Nonsense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:223786028C>G	uc002vni.2	+	c.836C>G	c.(835-837)TCA>TGA	p.S279*	ACSL3_uc002vnj.2_Nonsense_Mutation_p.S279*	NM_004457	NP_004448	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	279	Cytoplasmic (Potential).				long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			ovary(2)	2		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)									0.396739	265.146666	266.860239	73	111	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	223786028	223786028	179	2	C	G	G	G	377	29	ACSL3	5	3
BIRC6	57448	broad.mit.edu	37	2	32715142	32715142	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:32715142G>C	uc010ezu.2	+	c.8130G>C	c.(8128-8130)TGG>TGC	p.W2710C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2710					anti-apoptosis|apoptosis|post-translational protein modification	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					Pancreas(94;175 1509 16028 18060 45422)				1555				0.280277	263.560153	276.097057	81	208	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	32715142	32715142	1463	2	G	C	C	C	572	44	BIRC6	3	3
RNF103	7844	broad.mit.edu	37	2	86831831	86831831	+	Missense_Mutation	SNP	T	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:86831831T>G	uc002srn.2	-	c.1193A>C	c.(1192-1194)AAT>ACT	p.N398T	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Missense_Mutation_p.N259T	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	398					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1														0.460674	146.172672	146.291827	41	48	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	86831831	86831831	13900	2	T	G	G	G	676	52	RNF103	4	4
PARP15	165631	broad.mit.edu	37	3	122353866	122353866	+	Splice_Site_SNP	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:122353866G>A	uc003efm.2	+	c.1573_splice	c.e11-1	p.I525_splice	PARP15_uc003efn.2_Splice_Site_SNP_p.I330_splice|PARP15_uc003efo.1_Splice_Site_SNP_p.I272_splice|PARP15_uc003efp.1_Splice_Site_SNP_p.I291_splice|PARP15_uc011bjt.1_Splice_Site_SNP_p.I222_splice	NM_001113523	NP_001106995			poly (ADP-ribose) polymerase family, member 15						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0531)										0.291667	78.645764	82.388373	28	68	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	122353866	122353866	11876	3	G	A	A	A	429	33	PARP15	5	2
ACAD9	28976	broad.mit.edu	37	3	128621404	128621404	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:128621404G>C	uc003ela.3	+	c.891G>C	c.(889-891)ATG>ATC	p.M297I	ACAD9_uc010hsw.1_Missense_Mutation_p.M174I|ACAD9_uc011bks.1_Missense_Mutation_p.M174I|ACAD9_uc003elb.2_Missense_Mutation_p.M174I|ACAD9_uc003elc.1_Missense_Mutation_p.M115I|ACAD9_uc003eld.1_Non-coding_Transcript|ACAD9_uc003ele.2_5'Flank	NM_014049	NP_054768	Q9H845	ACAD9_HUMAN	acyl-Coenzyme A dehydrogenase family, member 9	297					oxidation-reduction process	mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			ovary(2)|central_nervous_system(1)	3														0.164474	60.684855	76.92386	25	127	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	128621404	128621404	112	3	G	C	C	C	585	45	ACAD9	3	3
SLC9A9	285195	broad.mit.edu	37	3	143550916	143550916	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:143550916C>T	uc003evn.2	-	c.323G>A	c.(322-324)AGA>AAA	p.R108K	SLC9A9_uc011bnk.1_Intron	NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	108					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)	2														0.283582	49.493527	52.313773	19	48	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	143550916	143550916	15218	3	C	T	T	T	416	32	SLC9A9	2	2
HPS3	84343	broad.mit.edu	37	3	148858845	148858845	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:148858845G>C	uc003ewu.1	+	c.754G>C	c.(754-756)GTC>CTC	p.V252L	HPS3_uc003ewt.1_Missense_Mutation_p.V252L|HPS3_uc011bnq.1_Missense_Mutation_p.V87L	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	252						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)											0.171233	62.079816	77.000986	25	121	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	148858845	148858845	7632	3	G	C	C	C	624	48	HPS3	3	3
HPS3	84343	broad.mit.edu	37	3	148858854	148858854	+	Missense_Mutation	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:148858854C>A	uc003ewu.1	+	c.763C>A	c.(763-765)CAG>AAG	p.Q255K	HPS3_uc003ewt.1_Missense_Mutation_p.Q255K|HPS3_uc011bnq.1_Missense_Mutation_p.Q90K	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	255						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)											0.189542	61.881572	75.677963	29	124	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	148858854	148858854	7632	3	C	A	A	A	273	21	HPS3	2	2
SELT	51714	broad.mit.edu	37	3	150344870	150344870	+	Missense_Mutation	SNP	T	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:150344870T>A	uc011bnx.1	+	c.537T>A	c.(535-537)AAT>AAA	p.N179K		NM_016275	NP_057359	P62341	SELT_HUMAN	selenoprotein T precursor	179					cell redox homeostasis|selenocysteine incorporation		selenium binding				0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)											0.30719	145.373284	150.440986	47	106	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	150344870	150344870	14508	3	T	A	A	A	660	51	SELT	3	3
SLITRK3	22865	broad.mit.edu	37	3	164908075	164908075	+	Missense_Mutation	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:164908075C>A	uc003fej.3	-	c.544G>T	c.(544-546)GAT>TAT	p.D182Y	SLITRK3_uc003fek.2_Missense_Mutation_p.D182Y	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	182	LRR 5.|Extracellular (Potential).					integral to membrane				ovary(6)|pancreas(1)	7														0.182857	61.683884	78.222371	32	143	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	164908075	164908075	15242	3	C	A	A	A	377	29	SLITRK3	2	2
TBC1D5	9779	broad.mit.edu	37	3	17550017	17550017	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:17550017C>T	uc010hev.2	-	c.46G>A	c.(46-48)GAA>AAA	p.E16K	TBC1D5_uc003cbf.2_Missense_Mutation_p.E16K|TBC1D5_uc003cbe.2_Missense_Mutation_p.E16K	NM_001134381	NP_001127853	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform a	16						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1														0.333333	145.247564	148.792272	48	96	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	17550017	17550017	16149	3	C	T	T	T	416	32	TBC1D5	2	2
CPN2	1370	broad.mit.edu	37	3	194063201	194063201	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:194063201C>T	uc003fts.2	-	c.231G>A	c.(229-231)AAG>AAA	p.K77K		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	77					protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)										0.173913	116.848569	146.82973	52	247	KEEP	---	---	---	---	capture		Silent	SNP	194063201	194063201	3948	3	C	T	T	T	311	24	CPN2	2	2
ZNF197	10168	broad.mit.edu	37	3	44684351	44684351	+	Nonsense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:44684351C>T	uc003cnm.2	+	c.1729C>T	c.(1729-1731)CGA>TGA	p.R577*	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	577	C2H2-type 8.				regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)										0.358491	110.719216	112.589	38	68	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	44684351	44684351	18350	3	C	T	T	T	399	31	ZNF197	5	1
FYCO1	79443	broad.mit.edu	37	3	46009262	46009262	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:46009262G>A	uc011bal.1	-	c.1564C>T	c.(1564-1566)CTG>TTG	p.L522L	FYCO1_uc003cpb.3_Silent_p.L522L	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	522	Potential.				transport	integral to membrane	protein binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)										0.322404	165.652287	170.78211	59	124	KEEP	---	---	---	---	capture		Silent	SNP	46009262	46009262	6376	3	G	A	A	A	438	34	FYCO1	2	2
MST1R	4486	broad.mit.edu	37	3	49940859	49940859	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:49940859C>T	uc003cxy.3	-	c.184G>A	c.(184-186)GAG>AAG	p.E62K	MST1R_uc011bdd.1_Missense_Mutation_p.E62K|MST1R_uc011bde.1_Missense_Mutation_p.E62K|MST1R_uc011bdf.1_Missense_Mutation_p.E62K|MST1R_uc011bdg.1_Missense_Mutation_p.E62K	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	62	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|protein phosphorylation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)						205				0.567308	185.436755	185.847663	59	45	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	49940859	49940859	10284	3	C	T	T	T	403	31	MST1R	1	1
EDEM1	9695	broad.mit.edu	37	3	5251931	5251931	+	Silent	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:5251931C>G	uc003bqi.2	+	c.1581C>G	c.(1579-1581)GTC>GTG	p.V527V	EDEM1_uc003bqh.2_Silent_p.V527V	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	527	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)										0.665138	541.639307	546.898497	145	73	KEEP	---	---	---	---	capture		Silent	SNP	5251931	5251931	5098	3	C	G	G	G	366	29	EDEM1	3	3
FAT4	79633	broad.mit.edu	37	4	126239448	126239448	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:126239448G>A	uc003ifj.3	+	c.1882G>A	c.(1882-1884)GAC>AAC	p.D628N		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	628	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(8)|pancreas(2)	10														0.301471	107.314102	112.106144	41	95	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	126239448	126239448	5928	4	G	A	A	A	585	45	FAT4	2	2
SMAD1	4086	broad.mit.edu	37	4	146467854	146467854	+	Splice_Site_SNP	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:146467854G>C	uc003ikc.2	+	c.776_splice	c.e5-1	p.D259_splice	SMAD1_uc003ikd.2_Splice_Site_SNP_p.D259_splice|SMAD1_uc010iov.2_Splice_Site_SNP_p.D259_splice|SMAD1_uc011cic.1_Splice_Site_SNP_p.D220_splice	NM_005900	NP_005891			Sma- and Mad-related protein 1						BMP signaling pathway|embryonic pattern specification|primary microRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					Pancreas(182;1287 2092 10326 35158 50562)								0.334711	272.696723	278.549318	81	161	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	146467854	146467854	15255	4	G	C	C	C	429	33	SMAD1	5	3
TACC3	10460	broad.mit.edu	37	4	1725529	1725529	+	Missense_Mutation	SNP	G	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:1725529G>T	uc003gdo.2	+	c.237G>T	c.(235-237)GAG>GAT	p.E79D	TMEM129_uc003gdn.2_5'Flank|TMEM129_uc003gdm.2_5'Flank|TACC3_uc010ibz.2_Missense_Mutation_p.E79D|TACC3_uc003gdp.2_Missense_Mutation_p.E79D	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	79						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			Ovarian(120;482 2294 11894 35824)				480				0.124638	51.593326	99.107972	43	302	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	1725529	1725529	16024	4	G	T	T	T	451	35	TACC3	2	2
TACC3	10460	broad.mit.edu	37	4	1730435	1730435	+	Nonsense_Mutation	SNP	G	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:1730435G>T	uc003gdo.2	+	c.1306G>T	c.(1306-1308)GAG>TAG	p.E436*	TACC3_uc010ibz.2_Nonsense_Mutation_p.E436*|TACC3_uc003gdp.2_Intron|TACC3_uc010ica.2_5'Flank	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	436						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			Ovarian(120;482 2294 11894 35824)				480				0.225681	115.171924	133.003776	58	199	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	1730435	1730435	16024	4	G	T	T	T	585	45	TACC3	5	2
ROPN1L	83853	broad.mit.edu	37	5	10442326	10442327	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:10442326_10442327CC>TT	uc003jex.3	+	c.47_48CC>TT	c.(46-48)CCC>CTT	p.P16L		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	16					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding				0														0.336538	106.591624	109.050464	35	69	KEEP	---	---	---	---	capture		Missense_Mutation	DNP	10442326	10442327	14004	5	CC	TT	TT	TT	286	22	ROPN1L	2	2
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139820670	139820670	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:139820670G>A	uc003lfs.1	+	c.856G>A	c.(856-858)GAT>AAT	p.D286N	ANKHD1_uc003lfq.1_Missense_Mutation_p.D286N|ANKHD1_uc003lfr.2_Missense_Mutation_p.D286N|ANKHD1_uc003lfp.2_Missense_Mutation_p.D275N|ANKHD1_uc003lfo.2_Missense_Mutation_p.D286N|ANKHD1_uc010jfk.2_Missense_Mutation_p.D286N	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	286						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.5625	57.152168	57.260805	18	14	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	139820670	139820670	632	5	G	A	A	A	429	33	ANKHD1-EIF4EBP3	2	2
PCDHA1	56147	broad.mit.edu	37	5	140167773	140167773	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140167773C>T	uc003lhb.2	+	c.1898C>T	c.(1897-1899)ACG>ATG	p.T633M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.T633M	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	633	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.538462	151.172868	151.289402	49	42	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	140167773	140167773	11939	5	C	T	T	T	247	19	PCDHA1	1	1
ADRB2	154	broad.mit.edu	37	5	148207101	148207101	+	Missense_Mutation	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:148207101C>A	uc003lpr.1	+	c.707C>A	c.(706-708)TCT>TAT	p.S236Y	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	236	Cytoplasmic.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)									0.571429	178.701504	179.166502	60	45	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	148207101	148207101	342	5	C	A	A	A	416	32	ADRB2	2	2
FBXL7	23194	broad.mit.edu	37	5	15928576	15928576	+	Silent	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:15928576C>A	uc003jfn.1	+	c.705C>A	c.(703-705)TCC>TCA	p.S235S		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	235	LRR 3.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3														0.328244	111.899895	115.31702	43	88	KEEP	---	---	---	---	capture		Silent	SNP	15928576	15928576	5961	5	C	A	A	A	275	22	FBXL7	2	2
DBN1	1627	broad.mit.edu	37	5	176887701	176887701	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:176887701C>T	uc003mgx.2	-	c.781G>A	c.(781-783)GAC>AAC	p.D261N	DBN1_uc011dga.1_5'UTR|DBN1_uc003mgy.2_Missense_Mutation_p.D259N|DBN1_uc010jkn.1_Missense_Mutation_p.D209N|DBN1_uc003mgz.1_Missense_Mutation_p.D196N	NM_080881	NP_543157	Q16643	DREB_HUMAN	drebrin 1 isoform b	259					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)	3	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)							168				0.727273	146.000625	149.063216	48	18	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	176887701	176887701	4423	5	C	T	T	T	377	29	DBN1	2	2
WDR70	55100	broad.mit.edu	37	5	37480018	37480018	+	Missense_Mutation	SNP	G	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:37480018G>C	uc003jkv.2	+	c.769G>C	c.(769-771)GAC>CAC	p.D257H	WDR70_uc010iva.1_Missense_Mutation_p.D257H	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	257	WD 2.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)											0.102564	23.877753	48.432927	16	140	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	37480018	37480018	17894	5	G	C	C	C	585	45	WDR70	3	3
KIAA1244	57221	broad.mit.edu	37	6	138656212	138656212	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:138656212C>T	uc003qhu.2	+	c.6229C>T	c.(6229-6231)CGG>TGG	p.R2077W		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	2077					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)										0.357143	13.770479	14.022401	5	9	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	138656212	138656212	8526	6	C	T	T	T	347	27	KIAA1244	1	1
SMOC2	64094	broad.mit.edu	37	6	169051407	169051407	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:169051407C>T	uc003qwr.1	+	c.987C>T	c.(985-987)GAC>GAT	p.D329D	SMOC2_uc003qws.1_Silent_p.D318D|SMOC2_uc011egu.1_De_novo_Start_OutOfFrame	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	318					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)										0.424242	41.544703	41.709864	14	19	KEEP	---	---	---	---	capture		Silent	SNP	169051407	169051407	15302	6	C	T	T	T	246	19	SMOC2	1	1
OR2J2	26707	broad.mit.edu	37	6	29141890	29141890	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:29141890C>G	uc011dlm.1	+	c.478C>G	c.(478-480)CAT>GAT	p.H160D		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0														0.235075	177.595997	194.794864	63	205	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	29141890	29141890	11409	6	C	G	G	G	377	29	OR2J2	3	3
OR2J2	26707	broad.mit.edu	37	6	29142165	29142165	+	Silent	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:29142165C>G	uc011dlm.1	+	c.753C>G	c.(751-753)CTC>CTG	p.L251L		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0														0.318841	146.158395	150.179601	44	94	KEEP	---	---	---	---	capture		Silent	SNP	29142165	29142165	11409	6	C	G	G	G	405	32	OR2J2	3	3
NRM	11270	broad.mit.edu	37	6	30657883	30657883	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:30657883G>A	uc003nrc.2	-	c.271C>T	c.(271-273)CGG>TGG	p.R91W	KIAA1949_uc003nra.2_5'Flank|KIAA1949_uc003nrb.3_5'Flank|NRM_uc003nrd.2_Non-coding_Transcript|NRM_uc003nre.2_Intron	NM_007243	NP_009174	Q8IXM6	NRM_HUMAN	nurim	91	Nuclear (Potential).					integral to membrane|nuclear inner membrane					0														0.346821	169.086663	172.652145	60	113	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	30657883	30657883	11062	6	G	A	A	A	506	39	NRM	1	1
CD109	135228	broad.mit.edu	37	6	74468721	74468721	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:74468721C>G	uc003php.2	+	c.728C>G	c.(727-729)TCT>TGT	p.S243C	CD109_uc010kaz.2_Missense_Mutation_p.S243C|CD109_uc003phq.2_Missense_Mutation_p.S243C|CD109_uc010kba.2_Missense_Mutation_p.S166C	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	243						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4														0.395349	60.366386	60.778531	17	26	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	74468721	74468721	3090	6	C	G	G	G	416	32	CD109	3	3
UBE2J1	51465	broad.mit.edu	37	6	90052103	90052103	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:90052103G>A	uc010kcb.2	-	c.177C>T	c.(175-177)CAC>CAT	p.H59H	UBE2J1_uc003pnc.2_Silent_p.H59H	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	59	Cytoplasmic (Potential).				post-translational protein modification	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)										0.433962	67.218804	67.419785	23	30	KEEP	---	---	---	---	capture		Silent	SNP	90052103	90052103	17417	6	G	A	A	A	516	40	UBE2J1	1	1
MUC17	140453	broad.mit.edu	37	7	100685800	100685800	+	Silent	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:100685800C>G	uc003uxp.1	+	c.11103C>G	c.(11101-11103)GTC>GTG	p.V3701V	MUC17_uc010lho.1_Non-coding_Transcript	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3701	Extracellular (Potential).|59.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|breast(3)|lung(2)	19	Lung NSC(181;0.136)|all_lung(186;0.182)													0.545946	377.193215	377.532672	101	84	KEEP	---	---	---	---	capture		Silent	SNP	100685800	100685800	10368	7	C	G	G	G	366	29	MUC17	3	3
C7orf33	202865	broad.mit.edu	37	7	148288208	148288208	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:148288208C>T	uc003wew.2	+	c.191C>T	c.(190-192)ACG>ATG	p.T64M		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	64											0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)											0.582418	166.476728	167.015164	53	38	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	148288208	148288208	2495	7	C	T	T	T	247	19	C7orf33	1	1
DPY19L1	23333	broad.mit.edu	37	7	35009108	35009108	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:35009108G>A	uc003tem.3	-	c.732C>T	c.(730-732)CTC>CTT	p.L244L		NM_015283	NP_056098	Q2PZI1	D19L1_HUMAN	dpy-19-like 1	244	Helical; (Potential).					integral to membrane					0														0.631579	39.294944	39.581847	12	7	KEEP	---	---	---	---	capture		Silent	SNP	35009108	35009108	4924	7	G	A	A	A	418	33	DPY19L1	2	2
ZNF804B	219578	broad.mit.edu	37	7	88964043	88964043	+	Missense_Mutation	SNP	T	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:88964043T>G	uc011khi.1	+	c.1747T>G	c.(1747-1749)TAC>GAC	p.Y583D		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	583						intracellular	zinc ion binding			ovary(5)|pancreas(2)	7	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)											0.613636	102.708209	103.201441	27	17	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	88964043	88964043	18769	7	T	G	G	G	793	61	ZNF804B	4	4
RIMS2	9699	broad.mit.edu	37	8	105105725	105105725	+	Missense_Mutation	SNP	A	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:105105725A>T	uc003yls.2	+	c.2748A>T	c.(2746-2748)AGA>AGT	p.R916S	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.R989S|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	370					intracellular protein transport	cell junction|presynaptic membrane	Rab GTPase binding|zinc ion binding			ovary(6)|lung(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)							728				0.38	109.520721	110.78569	38	62	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	105105725	105105725	13845	8	A	T	T	T	131	11	RIMS2	3	3
MTBP	27085	broad.mit.edu	37	8	121531009	121531009	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:121531009C>T	uc003ypc.1	+	c.2562C>T	c.(2560-2562)TTC>TTT	p.F854F		NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	854	Interaction with MDM2 (By similarity).				cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)											0.352941	77.630359	79.248425	30	55	KEEP	---	---	---	---	capture		Silent	SNP	121531009	121531009	10305	8	C	T	T	T	376	29	MTBP	2	2
PLEC	5339	broad.mit.edu	37	8	145010069	145010069	+	Silent	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:145010069G>A	uc003zaf.1	-	c.960C>T	c.(958-960)TTC>TTT	p.F320F	PLEC_uc003zab.1_Silent_p.F183F|PLEC_uc003zac.1_Silent_p.F187F|PLEC_uc003zad.2_Silent_p.F183F|PLEC_uc003zae.1_Silent_p.F151F|PLEC_uc003zag.1_Silent_p.F161F|PLEC_uc003zah.2_Silent_p.F169F|PLEC_uc003zaj.2_Silent_p.F210F	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	320	CH 2.|Globular 1.|Actin-binding.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|central_nervous_system(1)	7														0.365385	46.398113	47.231195	19	33	KEEP	---	---	---	---	capture		Silent	SNP	145010069	145010069	12478	8	G	A	A	A	581	45	PLEC	2	2
LPL	4023	broad.mit.edu	37	8	19809451	19809451	+	Missense_Mutation	SNP	T	C	C			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:19809451T>C	uc003wzk.3	+	c.421T>C	c.(421-423)TGG>CGG	p.W141R		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	141					chylomicron remodeling|fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)									0.302083	78.935945	82.294941	29	67	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	19809451	19809451	9294	8	T	C	C	C	715	55	LPL	4	4
DKK4	27121	broad.mit.edu	37	8	42233236	42233236	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:42233236C>T	uc003xpb.2	-	c.224G>A	c.(223-225)CGA>CAA	p.R75Q		NM_014420	NP_055235	Q9UBT3	DKK4_HUMAN	dickkopf homolog 4 precursor	75	DKK-type Cys-1.				multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				ovary(1)	1	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)											0.368421	98.502565	99.946905	35	60	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	42233236	42233236	4727	8	C	T	T	T	403	31	DKK4	1	1
PREX2	80243	broad.mit.edu	37	8	69104734	69104734	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:69104734C>T	uc003xxv.1	+	c.4578C>T	c.(4576-4578)ATC>ATT	p.I1526I		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1526					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			large_intestine(4)|pancreas(3)|lung(2)|skin(2)|ovary(1)|kidney(1)	13										1011				0.285714	19.986867	21.141665	8	20	KEEP	---	---	---	---	capture		Silent	SNP	69104734	69104734	12920	8	C	T	T	T	369	29	PREX2	2	2
SULF1	23213	broad.mit.edu	37	8	70533431	70533431	+	Silent	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:70533431C>G	uc010lza.1	+	c.1539C>G	c.(1537-1539)GCC>GCG	p.A513A	SULF1_uc003xyd.2_Silent_p.A513A|SULF1_uc003xye.2_Silent_p.A513A|SULF1_uc003xyf.2_Silent_p.A513A|SULF1_uc003xyg.2_Silent_p.A513A|SULF1_uc003xyh.1_Non-coding_Transcript	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	513					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)							473				0.418182	69.914001	70.235661	23	32	KEEP	---	---	---	---	capture		Silent	SNP	70533431	70533431	15890	8	C	G	G	G	262	21	SULF1	3	3
LRRC8A	56262	broad.mit.edu	37	9	131678377	131678377	+	Silent	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:131678377C>T	uc004bwl.3	+	c.2160C>T	c.(2158-2160)ATC>ATT	p.I720I	LRRC8A_uc010myp.2_Silent_p.I720I|LRRC8A_uc010myq.2_Silent_p.I720I	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	720	LRR 15.				pre-B cell differentiation	integral to membrane					0														0.560976	219.383515	219.781064	69	54	KEEP	---	---	---	---	capture		Silent	SNP	131678377	131678377	9397	9	C	T	T	T	395	31	LRRC8A	1	1
SH3GLB2	56904	broad.mit.edu	37	9	131784697	131784697	+	Silent	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:131784697C>A	uc004bww.2	-	c.69G>T	c.(67-69)ACG>ACT	p.T23T	SH3GLB2_uc004bwv.2_Silent_p.T23T|SH3GLB2_uc004bwx.1_Silent_p.T23T|SH3GLB2_uc011mbm.1_Silent_p.T23T	NM_020145	NP_064530	Q9NR46	SHLB2_HUMAN	SH3-domain GRB2-like endophilin B2	23	Membrane-binding amphipathic helix (By similarity).				filopodium assembly|signal transduction	cytoplasm|nucleus	cytoskeletal adaptor activity|SH3 domain binding				0														0.5	53.900436	53.900436	16	16	KEEP	---	---	---	---	capture		Silent	SNP	131784697	131784697	14746	9	C	A	A	A	288	23	SH3GLB2	1	1
TUBB2C	10383	broad.mit.edu	37	9	140137954	140137954	+	Silent	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:140137954C>A	uc004cmh.1	+	c.1284C>A	c.(1282-1284)GCC>GCA	p.A428A	TUBB2C_uc004cmg.1_Silent_p.A282A	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	428					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)										0.525773	153.721771	153.777333	51	46	KEEP	---	---	---	---	capture		Silent	SNP	140137954	140137954	17311	9	C	A	A	A	262	21	TUBB2C	2	2
KLHL9	55958	broad.mit.edu	37	9	21333798	21333798	+	Missense_Mutation	SNP	C	G	G			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:21333798C>G	uc003zoy.2	-	c.1061G>C	c.(1060-1062)GGT>GCT	p.G354A	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_Non-coding_Transcript	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	354	Kelch 2.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)	3				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)										0.259542	104.921346	111.761563	34	97	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	21333798	21333798	8710	9	C	G	G	G	234	18	KLHL9	3	3
ARX	170302	broad.mit.edu	37	X	25033723	25033723	+	Silent	SNP	C	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:25033723C>A	uc004dbp.3	-	c.132G>T	c.(130-132)CTG>CTT	p.L44L		NM_139058	NP_620689	Q96QS3	ARX_HUMAN	aristaless related homeobox	44					regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulator activity				0														0.5	23.61866	23.61866	9	9	KEEP	---	---	---	---	capture		Silent	SNP	25033723	25033723	1022	23	C	A	A	A	262	21	ARX	2	2
USP9X	8239	broad.mit.edu	37	X	41025388	41025388	+	Missense_Mutation	SNP	G	A	A			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:41025388G>A	uc004dfb.2	+	c.2249G>A	c.(2248-2250)CGA>CAA	p.R750Q	USP9X_uc004dfc.2_Missense_Mutation_p.R750Q	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	750					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			ovary(1)	1						Ovarian(172;1807 2695 35459 49286)								0.55	140.908646	141.08316	44	36	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	41025388	41025388	17654	23	G	A	A	A	481	37	USP9X	1	1
NLGN4X	57502	broad.mit.edu	37	X	5827179	5827179	+	Missense_Mutation	SNP	C	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:5827179C>T	uc010ndi.2	-	c.838G>A	c.(838-840)GGG>AGG	p.G280R	NLGN4X_uc004crp.2_Missense_Mutation_p.G263R|NLGN4X_uc010ndh.2_Missense_Mutation_p.G243R|NLGN4X_uc004crq.2_Missense_Mutation_p.G243R|NLGN4X_uc004crr.2_Missense_Mutation_p.G243R|NLGN4X_uc010ndj.2_Missense_Mutation_p.G243R	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	243	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|regulation of synaptic transmission|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	carboxylesterase activity|chloride ion binding|neurexin binding|protein homodimerization activity			large_intestine(1)|skin(1)	2														0.55814	76.985807	77.110292	24	19	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	5827179	5827179	10867	23	C	T	T	T	299	23	NLGN4X	1	1
PRKRIR	5612	broad.mit.edu	37	11	76062227	76062228	+	Frame_Shift_Ins	INS	-	T	T			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:76062227_76062228insT	uc001oxh.1	-	c.1966_1967insA	c.(1966-1968)ATAfs	p.I656fs	PRKRIR_uc010rrz.1_Frame_Shift_Ins_p.I481fs	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	656					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3														0.32			56	119		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	76062227	76062228	12969	11	-	T	T	T	208	16	PRKRIR	5	5
IPO8	10526	broad.mit.edu	37	12	30818182	30818184	+	In_Frame_Del	DEL	AAT	-	-			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:30818182_30818184delAAT	uc001rjd.2	-	c.1398_1400delATT	c.(1396-1401)TTATTG>TTG	p.466_467LL>L	IPO8_uc001rje.1_5'Flank|IPO8_uc010sjt.1_In_Frame_Del_p.261_262LL>L	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	466_467					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)													0.31			34	76		---	---	---	---	capture_indel		In_Frame_Del	DEL	30818182	30818184	8099	12	AAT	-	-	-	65	5	IPO8	5	5
AMDHD2	51005	broad.mit.edu	37	16	2578341	2578341	+	Frame_Shift_Del	DEL	C	-	-			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:2578341_2578341delC	uc010uwc.1	+	c.822_822delC	c.(820-822)AACfs	p.N274fs	AMDHD2_uc002cqp.2_Frame_Shift_Del_p.N274fs|AMDHD2_uc002cqq.2_Frame_Shift_Del_p.N274fs|AMDHD2_uc010uwd.1_Frame_Shift_Del_p.N38fs	NM_001145815	NP_001139287	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 2	274					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			large_intestine(1)|breast(1)	2														0.37			29	49		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	2578341	2578341	571	16	C	-	-	-	233	18	AMDHD2	5	5
SFRS16	11129	broad.mit.edu	37	19	45567607	45567609	+	In_Frame_Del	DEL	CTC	-	-			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:45567607_45567609delCTC	uc002pak.2	+	c.1128_1130delCTC	c.(1126-1131)CGCTCC>CGC	p.S385del	SFRS16_uc002pal.2_Non-coding_Transcript|SFRS16_uc010xxh.1_In_Frame_Del_p.S323del|SFRS16_uc002pam.2_In_Frame_Del_p.S385del	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	385	Ser-rich.|Arg-rich.				mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)										0.33			2	4		---	---	---	---	capture_indel		In_Frame_Del	DEL	45567607	45567609	14662	19	CTC	-	-	-	353	28	SFRS16	5	5
FAM120A	23196	broad.mit.edu	37	9	96323398	96323403	+	In_Frame_Del	DEL	ACCTAT	-	-			TCGA-38-4630-01	TCGA-38-4630-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:96323398_96323403delACCTAT	uc004atw.2	+	c.2814_2819delACCTAT	c.(2812-2820)CAACCTATA>CAA	p.PI939del	FAM120A_uc004aty.2_In_Frame_Del_p.PI720del|FAM120A_uc004atz.2_In_Frame_Del_p.PI587del|FAM120A_uc010mrg.2_In_Frame_Del_p.PI206del|FAM120A_uc004aua.1_5'Flank	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	939_940	RNA binding.					cytoplasm|plasma membrane	RNA binding				0														0.32			25	54		---	---	---	---	capture_indel		In_Frame_Del	DEL	96323398	96323403	5612	9	ACCTAT	-	-	-	24	2	FAM120A	5	5
