Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
SVIL	6840	broad.mit.edu	37	10	29819539	29819539	+	Silent	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:29819539G>A	uc001iut.1	-	c.2103C>T	c.(2101-2103)TTC>TTT	p.F701F	SVIL_uc001iuu.1_Silent_p.F307F	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	701					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)	5		Breast(68;0.103)												0.227373	274.074805	304.981937	103	350	KEEP	---	---	---	---	capture		Silent	SNP	29819539	29819539	15941	10	G	A	A	A	581	45	SVIL	2	2
C11orf63	79864	broad.mit.edu	37	11	122774779	122774779	+	Missense_Mutation	SNP	A	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:122774779A>G	uc001pym.2	+	c.491A>G	c.(490-492)TAC>TGC	p.Y164C	C11orf63_uc001pyl.1_Missense_Mutation_p.Y164C	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	164										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)										0.175439	25.057804	30.68553	10	47	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	122774779	122774779	1693	11	A	G	G	G	182	14	C11orf63	4	4
KAT5	10524	broad.mit.edu	37	11	65482336	65482336	+	Silent	SNP	C	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:65482336C>G	uc001ofk.2	+	c.984C>G	c.(982-984)CGC>CGG	p.R328R	KAT5_uc001ofi.2_Silent_p.R295R|KAT5_uc001ofj.2_Silent_p.R243R|KAT5_uc010roo.1_Silent_p.R276R|KAT5_uc001ofl.2_Silent_p.R84R	NM_182710	NP_874369	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 1	295					androgen receptor signaling pathway|chromatin assembly or disassembly|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of interleukin-2 production|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	chromatin|NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|chromatin binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity|transcription repressor activity				0														0.157895	65.507986	84.593113	27	144	KEEP	---	---	---	---	capture		Silent	SNP	65482336	65482336	8287	11	C	G	G	G	314	25	KAT5	3	3
ARAP1	116985	broad.mit.edu	37	11	72404811	72404811	+	Missense_Mutation	SNP	A	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:72404811A>G	uc001osu.2	-	c.3734T>C	c.(3733-3735)CTG>CCG	p.L1245P	ARAP1_uc001osv.2_Missense_Mutation_p.L1245P|ARAP1_uc001osr.2_Missense_Mutation_p.L1005P|ARAP1_uc001oss.2_Missense_Mutation_p.L1000P|ARAP1_uc009yth.2_Missense_Mutation_p.L939P|ARAP1_uc010rre.1_Missense_Mutation_p.L1000P	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1245	Ras-associating.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding				0						Ovarian(102;1198 1520 13195 17913 37529)								0.225	23.253284	26.033034	9	31	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	72404811	72404811	849	11	A	G	G	G	91	7	ARAP1	4	4
KRT73	319101	broad.mit.edu	37	12	53012246	53012246	+	Silent	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:53012246G>A	uc001sas.2	-	c.63C>T	c.(61-63)TCC>TCT	p.S21S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	21	Head.|Gly-rich.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)	4				BRCA - Breast invasive adenocarcinoma(357;0.189)										0.3125	31.540296	32.540684	10	22	KEEP	---	---	---	---	capture		Silent	SNP	53012246	53012246	8801	12	G	A	A	A	496	39	KRT73	1	1
KIAA1704	55425	broad.mit.edu	37	13	45582975	45582975	+	Silent	SNP	A	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:45582975A>G	uc001uzq.2	+	c.369A>G	c.(367-369)ACA>ACG	p.T123T	KIAA1704_uc010tfo.1_Non-coding_Transcript|KIAA1704_uc001uzr.1_Silent_p.T123T|KIAA1704_uc001uzs.2_5'UTR|KIAA1704_uc001uzt.2_5'UTR	NM_018559	NP_061029	Q8IXQ4	K1704_HUMAN	hypothetical protein LOC55425	123										pancreas(1)	1		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)										0.176471	29.056586	35.765076	12	56	KEEP	---	---	---	---	capture		Silent	SNP	45582975	45582975	8562	13	A	G	G	G	67	6	KIAA1704	4	4
RNASE4	6038	broad.mit.edu	37	14	21167803	21167803	+	Silent	SNP	A	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:21167803A>G	uc001vxy.3	+	c.273A>G	c.(271-273)CAA>CAG	p.Q91Q	RNASE4_uc001vxx.3_Non-coding_Transcript|RNASE4_uc001vya.2_Silent_p.Q91Q	NM_002937	NP_002928	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	91					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		Esophageal Squamous(59;1059 1362 26290 51151)								0.045564	-90.87553	93.066354	38	796	KEEP	---	---	---	---	capture		Silent	SNP	21167803	21167803	13883	14	A	G	G	G	50	4	RNASE4	4	4
FOXA1	3169	broad.mit.edu	37	14	38061461	38061461	+	Missense_Mutation	SNP	G	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:38061461G>C	uc001wuf.2	-	c.528C>G	c.(526-528)ATC>ATG	p.I176M	FOXA1_uc010tpz.1_Missense_Mutation_p.I143M	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	176	Fork-head.				chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)										0.256098	65.635283	70.058964	21	61	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	38061461	38061461	6231	14	G	C	C	C	421	33	FOXA1	3	3
PAPOLA	10914	broad.mit.edu	37	14	97022682	97022682	+	Missense_Mutation	SNP	A	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:97022682A>G	uc001yfq.2	+	c.1936A>G	c.(1936-1938)ATA>GTA	p.I646V	PAPOLA_uc001yfr.2_Missense_Mutation_p.I645V|PAPOLA_uc010twv.1_Missense_Mutation_p.I646V|PAPOLA_uc010avp.2_Missense_Mutation_p.I396V	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	646					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		NSCLC(19;254 734 11908 35501 39234)								0.196078	165.027165	191.362593	60	246	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	97022682	97022682	11846	14	A	G	G	G	208	16	PAPOLA	4	4
PDIA3	2923	broad.mit.edu	37	15	44038800	44038800	+	Silent	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:44038800C>T	uc001zsu.2	+	c.63C>T	c.(61-63)CTC>CTT	p.L21L	PDIA3_uc010bdp.2_5'UTR|PDIA3_uc010ued.1_Intron|CATSPER2P1_uc001zss.2_5'Flank|CATSPER2P1_uc001zst.2_Non-coding_Transcript	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	21					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)										0.25	7.418517	8.101008	3	9	KEEP	---	---	---	---	capture		Silent	SNP	44038800	44038800	12090	15	C	T	T	T	392	31	PDIA3	1	1
THSD4	79875	broad.mit.edu	37	15	72020908	72020908	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:72020908C>T	uc002atb.1	+	c.1378C>T	c.(1378-1380)CGC>TGC	p.R460C	THSD4_uc002atd.1_Missense_Mutation_p.R134C|THSD4_uc010ukg.1_Missense_Mutation_p.R100C|THSD4_uc002ate.2_Missense_Mutation_p.R100C	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	460						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2														0.217786	312.745502	353.165927	120	431	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	72020908	72020908	16406	15	C	T	T	T	247	19	THSD4	1	1
PDILT	204474	broad.mit.edu	37	16	20370667	20370667	+	Missense_Mutation	SNP	T	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:20370667T>C	uc002dhc.1	-	c.1729A>G	c.(1729-1731)AAA>GAA	p.K577E		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	577					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1														0.094142	46.798739	125.914324	45	433	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20370667	20370667	12095	16	T	C	C	C	806	62	PDILT	4	4
TMCO7	79613	broad.mit.edu	37	16	68941376	68941376	+	Silent	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:68941376G>A	uc002ewi.3	+	c.1698G>A	c.(1696-1698)CAG>CAA	p.Q566Q		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	566						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)										0.120482	45.567019	80.739326	30	219	KEEP	---	---	---	---	capture		Silent	SNP	68941376	68941376	16531	16	G	A	A	A	425	33	TMCO7	2	2
CLEC3A	10143	broad.mit.edu	37	16	78064470	78064470	+	Missense_Mutation	SNP	A	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:78064470A>G	uc002ffh.3	+	c.326A>G	c.(325-327)GAC>GGC	p.D109G		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	109	C-type lectin.				skeletal system development	extracellular region	sugar binding				0														0.123153	45.829814	74.035131	25	178	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	78064470	78064470	3648	16	A	G	G	G	130	10	CLEC3A	4	4
DSC2	1824	broad.mit.edu	37	18	28671107	28671107	+	Silent	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:28671107G>A	uc002kwl.3	-	c.358C>T	c.(358-360)CTA>TTA	p.L120L	DSC2_uc002kwk.3_Silent_p.L120L	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	120					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.0241)											0.141026	22.469186	32.169044	11	67	KEEP	---	---	---	---	capture		Silent	SNP	28671107	28671107	4950	18	G	A	A	A	451	35	DSC2	2	2
NOTCH3	4854	broad.mit.edu	37	19	15300136	15300136	+	Silent	SNP	A	G	G	rs61749020	by1000genomes	TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:15300136A>G	uc002nan.2	-	c.1140T>C	c.(1138-1140)CCT>CCC	p.P380P	NOTCH3_uc002nao.1_Silent_p.P380P	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	380	Extracellular (Potential).|EGF-like 9.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			ovary(5)|lung(2)|central_nervous_system(1)	8			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)							417				0.116279	9.043655	15.273855	5	38	KEEP	---	---	---	---	capture		Silent	SNP	15300136	15300136	10953	19	A	G	G	G	132	11	NOTCH3	4	4
REXO1	57455	broad.mit.edu	37	19	1828148	1828148	+	Missense_Mutation	SNP	G	A	A	rs77108843	by1000genomes	TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:1828148G>A	uc002lua.3	-	c.640C>T	c.(640-642)CGC>TGC	p.R214C	REXO1_uc010dsr.1_Missense_Mutation_p.R168C	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	214						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)										0.75	10.727821	10.954169	3	1	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	1828148	1828148	13711	19	G	A	A	A	507	39	REXO1	1	1
CSF1	1435	broad.mit.edu	37	1	110465931	110465931	+	Missense_Mutation	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:110465931G>A	uc001dyu.2	+	c.688G>A	c.(688-690)GAG>AAG	p.E230K	CSF1_uc001dyt.2_Missense_Mutation_p.E230K|CSF1_uc001dyv.3_Intron|CSF1_uc001dyw.3_Missense_Mutation_p.E230K	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	230	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)								OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.142857	16.33048	24.075051	9	54	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	110465931	110465931	4072	1	G	A	A	A	585	45	CSF1	2	2
AMPD1	270	broad.mit.edu	37	1	115222965	115222965	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:115222965C>T	uc001efe.1	-	c.682G>A	c.(682-684)GAG>AAG	p.E228K	AMPD1_uc001eff.1_Missense_Mutation_p.E224K	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	228					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)									0.085174	11.06068	66.400654	27	290	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	115222965	115222965	588	1	C	T	T	T	377	29	AMPD1	2	2
AQP10	89872	broad.mit.edu	37	1	154296116	154296116	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:154296116C>T	uc001feu.2	+	c.541C>T	c.(541-543)CGG>TGG	p.R181W	AQP10_uc001fev.2_Missense_Mutation_p.R181W|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	181	Cytoplasmic (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)											0.057143	-11.206096	17.609161	8	132	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	154296116	154296116	833	1	C	T	T	T	243	19	AQP10	1	1
DDR2	4921	broad.mit.edu	37	1	162740301	162740301	+	Silent	SNP	A	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:162740301A>G	uc001gcf.2	+	c.1503A>G	c.(1501-1503)TCA>TCG	p.S501S	DDR2_uc001gcg.2_Silent_p.S501S	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	501	Cytoplasmic (Potential).				cell adhesion|protein phosphorylation	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			NSCLC(161;314 2006 8283 19651 23192)				497				0.104839	13.182033	32.438237	13	111	KEEP	---	---	---	---	capture		Silent	SNP	162740301	162740301	4508	1	A	G	G	G	80	7	DDR2	4	4
C1orf58	148362	broad.mit.edu	37	1	222900585	222900585	+	Missense_Mutation	SNP	T	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:222900585T>C	uc001hnq.1	+	c.656T>C	c.(655-657)TTC>TCC	p.F219S	C1orf58_uc010put.1_Missense_Mutation_p.F187S|C1orf58_uc010puu.1_Missense_Mutation_p.F219S|C1orf58_uc010puv.1_Missense_Mutation_p.F187S	NM_144695	NP_653296	Q5VW32	BROX_HUMAN	Bro1-domain-containing protein	219	BRO1.					membrane					0				GBM - Glioblastoma multiforme(131;0.0667)										0.17931	66.759499	80.788667	26	119	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	222900585	222900585	2124	1	T	C	C	C	806	62	C1orf58	4	4
OR14A16	284532	broad.mit.edu	37	1	247978972	247978972	+	Missense_Mutation	SNP	A	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:247978972A>C	uc001idm.1	-	c.60T>G	c.(58-60)AAT>AAG	p.N20K		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						Ovarian(112;180 1586 15073 21914 33526)								0.239521	119.33079	129.665067	40	127	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	247978972	247978972	11351	1	A	C	C	C	206	16	OR14A16	4	4
GPN2	54707	broad.mit.edu	37	1	27216290	27216290	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:27216290C>T	uc001bnd.1	-	c.298G>A	c.(298-300)GAC>AAC	p.D100N		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	100							GTP binding				0														0.116667	9.088983	17.756846	7	53	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	27216290	27216290	6892	1	C	T	T	T	403	31	GPN2	1	1
C1orf94	84970	broad.mit.edu	37	1	34666634	34666634	+	Splice_Site_SNP	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:34666634G>A	uc001bxt.2	+	c.1270_splice	c.e3+1	p.F424_splice	C1orf94_uc001bxs.3_Splice_Site_SNP_p.F234_splice	NM_001134734	NP_001128206			hypothetical protein LOC84970 isoform a								protein binding				0		Myeloproliferative disorder(586;0.0393)												0.210526	9.989265	11.462174	4	15	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	34666634	34666634	2147	1	G	A	A	A	624	48	C1orf94	5	2
PFKL	5211	broad.mit.edu	37	21	45738376	45738376	+	Silent	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:45738376G>A	uc002zel.2	+	c.960G>A	c.(958-960)GCG>GCA	p.A320A	PFKL_uc002zek.2_Silent_p.A367A|PFKL_uc002zem.2_5'Flank|PFKL_uc002zen.2_5'Flank	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	320					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)										0.333333	6.348249	6.495728	2	4	KEEP	---	---	---	---	capture		Silent	SNP	45738376	45738376	12186	21	G	A	A	A	496	39	PFKL	1	1
CNTNAP5	129684	broad.mit.edu	37	2	125671706	125671706	+	Silent	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:125671706C>T	uc010flu.2	+	c.3765C>T	c.(3763-3765)ATC>ATT	p.I1255I	CNTNAP5_uc002tno.2_Silent_p.I1254I	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1254	Helical; (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)										0.068452	-21.380586	108.050353	46	626	KEEP	---	---	---	---	capture		Silent	SNP	125671706	125671706	3788	2	C	T	T	T	369	29	CNTNAP5	2	2
SCN7A	6332	broad.mit.edu	37	2	167301341	167301341	+	Silent	SNP	T	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:167301341T>C	uc002udu.1	-	c.1557A>G	c.(1555-1557)GTA>GTG	p.V519V	SCN7A_uc010fpm.1_Non-coding_Transcript	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	519	Helical; Name=S1 of repeat II; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1														0.235294	36.473979	39.74187	12	39	KEEP	---	---	---	---	capture		Silent	SNP	167301341	167301341	14405	2	T	C	C	C	626	49	SCN7A	4	4
ATF2	1386	broad.mit.edu	37	2	175982723	175982723	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:175982723C>T	uc002ujl.2	-	c.442G>A	c.(442-444)GAG>AAG	p.E148K	ATF2_uc010fqv.2_Missense_Mutation_p.E99K|ATF2_uc002ujv.2_5'UTR|ATF2_uc002ujm.2_Missense_Mutation_p.E90K|ATF2_uc002ujn.2_Non-coding_Transcript|ATF2_uc002ujo.2_Intron|ATF2_uc002ujp.2_Non-coding_Transcript|ATF2_uc002ujq.2_Missense_Mutation_p.E148K|ATF2_uc002ujr.2_Non-coding_Transcript|ATF2_uc010fqu.2_Missense_Mutation_p.E130K|ATF2_uc002ujs.2_Missense_Mutation_p.E90K|ATF2_uc002ujt.2_Non-coding_Transcript|ATF2_uc002uju.2_Non-coding_Transcript|ATF2_uc002ujw.1_Missense_Mutation_p.E90K|ATF2_uc002ujx.1_Non-coding_Transcript|ATF2_uc002ujy.1_Missense_Mutation_p.E148K	NM_001880	NP_001871	P15336	ATF2_HUMAN	activating transcription factor 2	148					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|RNA polymerase II transcription factor activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.125)			Pancreas(17;87 705 4534 15538 30988)				377				0.232143	106.334653	117.374985	39	129	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	175982723	175982723	1099	2	C	T	T	T	377	29	ATF2	2	2
CASP8	841	broad.mit.edu	37	2	202131375	202131375	+	Nonsense_Mutation	SNP	G	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:202131375G>T	uc002uxt.1	+	c.343G>T	c.(343-345)GAA>TAA	p.E115*	CASP8_uc010ftc.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxo.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxp.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxq.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxr.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxs.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxu.1_Non-coding_Transcript|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxw.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxy.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxx.1_Nonsense_Mutation_p.E56*|CASP8_uc010ftf.2_Nonsense_Mutation_p.E56*	NM_001080125	NP_001073594	Q14790	CASP8_HUMAN	caspase 8 isoform G precursor	56	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(1)|skin(1)	2						Melanoma(82;831 1348 20716 36952 40159)				239				0.165414	44.659787	58.792117	22	111	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	202131375	202131375	2796	2	G	T	T	T	533	41	CASP8	5	2
CASP8	841	broad.mit.edu	37	2	202137390	202137390	+	Missense_Mutation	SNP	G	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:202137390G>C	uc002uxt.1	+	c.618G>C	c.(616-618)GAG>GAC	p.E206D	CASP8_uc010ftc.1_Missense_Mutation_p.E147D|CASP8_uc002uxo.1_Missense_Mutation_p.E147D|CASP8_uc002uxp.1_Missense_Mutation_p.E179D|CASP8_uc002uxq.1_Missense_Mutation_p.E147D|CASP8_uc002uxr.1_Missense_Mutation_p.E147D|CASP8_uc002uxs.1_Missense_Mutation_p.E147D|CASP8_uc002uxu.1_Non-coding_Transcript|CASP8_uc010ftd.1_Missense_Mutation_p.E44D|CASP8_uc002uxv.1_Missense_Mutation_p.E147D|CASP8_uc002uxw.1_Missense_Mutation_p.E147D|CASP8_uc002uxy.1_Missense_Mutation_p.E147D|CASP8_uc002uxx.1_Missense_Mutation_p.E147D|CASP8_uc010ftf.2_Missense_Mutation_p.E147D|CASP8_uc010fte.1_Missense_Mutation_p.E44D	NM_001080125	NP_001073594	Q14790	CASP8_HUMAN	caspase 8 isoform G precursor	147	DED 2.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(1)|skin(1)	2						Melanoma(82;831 1348 20716 36952 40159)				239				0.167722	131.765172	164.828433	53	263	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	202137390	202137390	2796	2	G	C	C	C	425	33	CASP8	3	3
PTMA	5757	broad.mit.edu	37	2	232577559	232577559	+	Nonstop_Mutation	SNP	T	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:232577559T>C	uc002vsc.3	+	c.334T>C	c.(334-336)TAG>CAG	p.*112Q	PTMA_uc002vsb.3_Nonstop_Mutation_p.*111Q|PTMA_uc010zmf.1_Non-coding_Transcript|MIR1244_hsa-mir-1244-1|MI0006379_5'Flank	NM_001099285	NP_001092755	P06454	PTMA_HUMAN	prothymosin, alpha isoform 1	112					transcription, DNA-dependent	nucleus					0		Renal(207;0.0112)|all_hematologic(139;0.0315)|Acute lymphoblastic leukemia(138;0.0921)|all_lung(227;0.142)		Epithelial(121;1.75e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00221)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)										0.222222	5.945672	6.584052	2	7	KEEP	---	---	---	---	capture		Nonstop_Mutation	SNP	232577559	232577559	13221	2	T	C	C	C	689	53	PTMA	5	4
SOS1	6654	broad.mit.edu	37	2	39278344	39278344	+	Missense_Mutation	SNP	T	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:39278344T>C	uc002rrk.3	-	c.805A>G	c.(805-807)ATG>GTG	p.M269V	SOS1_uc010ynr.1_Non-coding_Transcript|SOS1_uc002rrl.2_Missense_Mutation_p.M1V	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	269	DH.		M -> R (in NS4).|M -> T (in NS4).		apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|lung(1)|central_nervous_system(1)	6		all_hematologic(82;0.21)								444				0.243421	114.900177	124.01945	37	115	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	39278344	39278344	15436	2	T	C	C	C	676	52	SOS1	4	4
LRRTM4	80059	broad.mit.edu	37	2	77746185	77746185	+	Silent	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:77746185C>T	uc002snr.2	-	c.810G>A	c.(808-810)CCG>CCA	p.P270P	LRRTM4_uc002snq.2_Silent_p.P270P|LRRTM4_uc002sns.2_Silent_p.P270P|LRRTM4_uc002snt.2_Silent_p.P271P	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	270	LRR 9.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)										0.297297	35.011785	36.370238	11	26	KEEP	---	---	---	---	capture		Silent	SNP	77746185	77746185	9418	2	C	T	T	T	288	23	LRRTM4	1	1
PLXNA1	5361	broad.mit.edu	37	3	126747837	126747837	+	Silent	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:126747837G>A	uc003ejg.2	+	c.4602G>A	c.(4600-4602)GAG>GAA	p.E1534E	PLXNA1_uc003ejh.2_Silent_p.E202E	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1557	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(114;0.155)										0.333333	22.018183	22.534705	7	14	KEEP	---	---	---	---	capture		Silent	SNP	126747837	126747837	12545	3	G	A	A	A	464	36	PLXNA1	2	2
NGLY1	55768	broad.mit.edu	37	3	25824758	25824758	+	Missense_Mutation	SNP	T	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:25824758T>C	uc003cdl.2	-	c.124A>G	c.(124-126)ATC>GTC	p.I42V	NGLY1_uc010hfg.2_Missense_Mutation_p.I42V|NGLY1_uc003cdm.2_Missense_Mutation_p.I42V|NGLY1_uc011awo.1_Intron	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	42	PUB.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1														0.3	16.039215	16.755917	6	14	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	25824758	25824758	10798	3	T	C	C	C	663	51	NGLY1	4	4
NDUFAF3	25915	broad.mit.edu	37	3	49060156	49060156	+	Missense_Mutation	SNP	A	G	G			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:49060156A>G	uc003cvq.2	+	c.292A>G	c.(292-294)ACC>GCC	p.T98A	DALRD3_uc003cvm.1_5'Flank|DALRD3_uc010hko.1_5'Flank|MIR425_hsa-mir-425|MI0001448_5'Flank|NDUFAF3_uc003cvn.2_Missense_Mutation_p.T41A|MIR191_hsa-mir-191|MI0000465_5'Flank|NDUFAF3_uc003cvp.2_Missense_Mutation_p.T41A|NDUFAF3_uc003cvr.2_Missense_Mutation_p.T41A|NDUFAF3_uc003cvs.2_Missense_Mutation_p.T41A	NM_199069	NP_951032	Q9BU61	NDUF3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	98					mitochondrial respiratory chain complex I assembly	mitochondrial inner membrane|nucleus	protein binding				0														0.13986	31.915291	50.03121	20	123	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	49060156	49060156	10675	3	A	G	G	G	78	6	NDUFAF3	4	4
MST1R	4486	broad.mit.edu	37	3	49928032	49928032	+	Silent	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:49928032G>A	uc003cxy.3	-	c.3696C>T	c.(3694-3696)GAC>GAT	p.D1232D	MST1R_uc011bdc.1_Silent_p.D111D	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1232	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|protein phosphorylation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)						205				0.150943	15.862926	22.05089	8	45	KEEP	---	---	---	---	capture		Silent	SNP	49928032	49928032	10284	3	G	A	A	A	620	48	MST1R	2	2
COL25A1	84570	broad.mit.edu	37	4	109817864	109817864	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:109817864C>T	uc003hze.1	-	c.865G>A	c.(865-867)GAC>AAC	p.D289N	COL25A1_uc003hzg.2_Missense_Mutation_p.D289N|COL25A1_uc003hzd.2_Non-coding_Transcript|COL25A1_uc003hzf.2_Missense_Mutation_p.D70N	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	289	Extracellular (Potential).|Collagen-like 3.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)										0.219048	196.899333	219.80703	69	246	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	109817864	109817864	3822	4	C	T	T	T	416	32	COL25A1	2	2
NAA15	80155	broad.mit.edu	37	4	140265339	140265339	+	Splice_Site_SNP	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:140265339G>A	uc003ihu.1	+	c.538_splice	c.e6-1	p.T180_splice		NM_057175	NP_476516			NMDA receptor regulated 1						angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)	1														0.078431	1.758368	11.020355	4	47	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	140265339	140265339	10513	4	G	A	A	A	429	33	NAA15	5	2
TRIM60	166655	broad.mit.edu	37	4	165962566	165962566	+	Missense_Mutation	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:165962566G>A	uc003iqy.1	+	c.1342G>A	c.(1342-1344)GTT>ATT	p.V448I	TRIM60_uc010iqx.1_Missense_Mutation_p.V448I	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	448	B30.2/SPRY.					intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)										0.130435	10.517303	16.628378	6	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	165962566	165962566	17081	4	G	A	A	A	520	40	TRIM60	1	1
FAM149A	25854	broad.mit.edu	37	4	187084634	187084634	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:187084634C>T	uc003iyt.3	+	c.890C>T	c.(889-891)CCG>CTG	p.P297L	FAM149A_uc011cla.1_Missense_Mutation_p.P297L|FAM149A_uc003iyu.3_Missense_Mutation_p.P297L|FAM149A_uc010isl.2_Missense_Mutation_p.P297L|FAM149A_uc011clb.1_Missense_Mutation_p.P297L	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	588										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)										0.2	109.416169	127.400277	43	172	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	187084634	187084634	5652	4	C	T	T	T	299	23	FAM149A	1	1
SPRY4	81848	broad.mit.edu	37	5	141693820	141693820	+	Missense_Mutation	SNP	G	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:141693820G>C	uc010jgi.1	-	c.923C>G	c.(922-924)GCA>GGA	p.A308G	SPRY4_uc003lml.2_Missense_Mutation_p.A285G	NM_030964	NP_112226	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 1	285					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.182927	35.178163	42.916158	15	67	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	141693820	141693820	15622	5	G	C	C	C	598	46	SPRY4	3	3
KCNMB1	3779	broad.mit.edu	37	5	169812334	169812334	+	Missense_Mutation	SNP	G	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:169812334G>T	uc003maq.1	-	c.118C>A	c.(118-120)CCC>ACC	p.P40T	KCNIP1_uc003map.2_Intron|KCNMB1_uc003mar.2_Missense_Mutation_p.P40T	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	40	Extracellular (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)										0.139706	35.029549	52.082059	19	117	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	169812334	169812334	8379	5	G	T	T	T	546	42	KCNMB1	2	2
GPR98	84059	broad.mit.edu	37	5	89923108	89923108	+	Silent	SNP	C	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:89923108C>A	uc003kju.2	+	c.753C>A	c.(751-753)TCC>TCA	p.S251S	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	251	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)										0.107143	9.10732	21.978691	9	75	KEEP	---	---	---	---	capture		Silent	SNP	89923108	89923108	6997	5	C	A	A	A	262	21	GPR98	2	2
MAP7	9053	broad.mit.edu	37	6	136681011	136681011	+	Missense_Mutation	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:136681011G>A	uc011edg.1	-	c.1949C>T	c.(1948-1950)ACC>ATC	p.T650I	MAP7_uc011edf.1_Missense_Mutation_p.T605I|MAP7_uc010kgu.2_Missense_Mutation_p.T642I|MAP7_uc011edh.1_Missense_Mutation_p.T605I|MAP7_uc010kgv.2_Missense_Mutation_p.T642I|MAP7_uc010kgs.2_Missense_Mutation_p.T474I|MAP7_uc011edi.1_Missense_Mutation_p.T474I|MAP7_uc003qgz.2_Missense_Mutation_p.T620I|MAP7_uc010kgq.1_Missense_Mutation_p.T526I|MAP7_uc003qha.1_Missense_Mutation_p.T583I	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	620					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)										0.215827	78.274563	88.630541	30	109	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	136681011	136681011	9649	6	G	A	A	A	572	44	MAP7	2	2
GRM1	2911	broad.mit.edu	37	6	146351336	146351336	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:146351336C>T	uc010khw.1	+	c.683C>T	c.(682-684)TCT>TTT	p.S228F	GRM1_uc010khu.1_Missense_Mutation_p.S228F|GRM1_uc010khv.1_Missense_Mutation_p.S228F|GRM1_uc003qll.2_Missense_Mutation_p.S228F|GRM1_uc011edz.1_Missense_Mutation_p.S228F|GRM1_uc011eea.1_Missense_Mutation_p.S228F	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	228	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			ovary(4)|central_nervous_system(3)|large_intestine(2)	9		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)									0.137255	50.352035	76.333708	28	176	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	146351336	146351336	7075	6	C	T	T	T	416	32	GRM1	2	2
F13A1	2162	broad.mit.edu	37	6	6167746	6167746	+	Missense_Mutation	SNP	T	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:6167746T>C	uc003mwv.2	-	c.1853A>G	c.(1852-1854)GAT>GGT	p.D618G	F13A1_uc011dib.1_Missense_Mutation_p.D555G	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	618					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)									0.118421	47.578988	80.170619	27	201	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	6167746	6167746	5534	6	T	C	C	C	650	50	F13A1	4	4
WRN	7486	broad.mit.edu	37	8	30945312	30945312	+	Missense_Mutation	SNP	T	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:30945312T>A	uc003xio.3	+	c.1452T>A	c.(1450-1452)AGT>AGA	p.S484R	WRN_uc011lbe.1_Missense_Mutation_p.S12R|WRN_uc010lvk.2_5'UTR	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	484					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)	5		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		Ovarian(18;161 598 2706 14834 27543)				832				0.16041	107.139979	139.29892	47	246	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	30945312	30945312	17976	8	T	A	A	A	764	59	WRN	3	3
NRG1	3084	broad.mit.edu	37	8	32621515	32621515	+	Silent	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:32621515G>A	uc003xiu.2	+	c.1533G>A	c.(1531-1533)GCG>GCA	p.A511A	NRG1_uc010lvo.2_3'UTR|NRG1_uc003xiw.2_Silent_p.A503A|NRG1_uc003xit.2_3'UTR|NRG1_uc003xiv.2_Silent_p.A506A|NRG1_uc010lvr.2_Silent_p.A248A|NRG1_uc010lvs.2_Silent_p.A248A|NRG1_uc010lvp.2_Silent_p.A460A|NRG1_uc010lvq.2_Silent_p.A443A|NRG1_uc011lbg.1_3'UTR|NRG1_uc011lbh.1_Silent_p.A349A|NRG1_uc003xja.2_Silent_p.A317A	NM_013956	NP_039250	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-beta1	506	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)										0.09901	8.82309	25.01733	10	91	KEEP	---	---	---	---	capture		Silent	SNP	32621515	32621515	11052	8	G	A	A	A	483	38	NRG1	1	1
HSPA5	3309	broad.mit.edu	37	9	128000573	128000573	+	Missense_Mutation	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:128000573G>A	uc004bpn.2	-	c.1249C>T	c.(1249-1251)CTT>TTT	p.L417F		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	417					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|negative regulation of caspase activity|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)	3					Antihemophilic Factor(DB00025)						Prostate(1;0.17)			0.170732	46.193344	58.807799	21	102	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	128000573	128000573	7713	9	G	A	A	A	442	34	HSPA5	2	2
APBA1	320	broad.mit.edu	37	9	72131361	72131361	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:72131361C>T	uc004ahh.2	-	c.766G>A	c.(766-768)GCG>ACG	p.A256T		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	256	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1														0.26087	16.340045	17.530115	6	17	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	72131361	72131361	766	9	C	T	T	T	351	27	APBA1	1	1
IL1RAPL1	11141	broad.mit.edu	37	X	29938182	29938182	+	Missense_Mutation	SNP	G	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:29938182G>A	uc004dby.2	+	c.1028G>A	c.(1027-1029)CGA>CAA	p.R343Q		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	343	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5														0.080645	7.902192	52.355698	20	228	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	29938182	29938182	7962	23	G	A	A	A	481	37	IL1RAPL1	1	1
MXRA5	25878	broad.mit.edu	37	X	3241386	3241386	+	Silent	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:3241386C>T	uc004crg.3	-	c.2340G>A	c.(2338-2340)CCG>CCA	p.P780P		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	780						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(23;0.00031)|Lung NSC(23;0.000946)												0.159204	71.079175	93.310918	32	169	KEEP	---	---	---	---	capture		Silent	SNP	3241386	3241386	10397	23	C	T	T	T	288	23	MXRA5	1	1
PLP2	5355	broad.mit.edu	37	X	49029495	49029495	+	Missense_Mutation	SNP	T	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:49029495T>C	uc004dmx.2	+	c.116T>C	c.(115-117)CTG>CCG	p.L39P		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	39	Helical; (Potential).|MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0														0.12	17.325228	31.493971	12	88	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	49029495	49029495	12531	23	T	C	C	C	715	55	PLP2	4	4
GSPT2	23708	broad.mit.edu	37	X	51487353	51487353	+	Missense_Mutation	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:51487353C>T	uc004dpl.2	+	c.631C>T	c.(631-633)CAT>TAT	p.H211Y		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	211	GTP (By similarity).				cell cycle|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)													0.064935	-2.690369	12.453914	5	72	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	51487353	51487353	7107	23	C	T	T	T	273	21	GSPT2	2	2
MSN	4478	broad.mit.edu	37	X	64959737	64959737	+	Silent	SNP	C	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:64959737C>T	uc004dwf.2	+	c.1716C>T	c.(1714-1716)GAC>GAT	p.D572D		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	572					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(2)	8										172				0.058111	-56.00231	113.004431	48	778	KEEP	---	---	---	---	capture		Silent	SNP	64959737	64959737	10278	23	C	T	T	T	246	19	MSN	1	1
FAM46D	169966	broad.mit.edu	37	X	79698599	79698599	+	Nonsense_Mutation	SNP	C	A	A			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:79698599C>A	uc004edl.1	+	c.561C>A	c.(559-561)TAC>TAA	p.Y187*	FAM46D_uc004edm.1_Nonsense_Mutation_p.Y187*	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	187										lung(2)	2														0.102564	18.275913	42.834543	16	140	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	79698599	79698599	5789	23	C	A	A	A	220	17	FAM46D	5	2
LRDD	55367	broad.mit.edu	37	11	799980	799981	+	Frame_Shift_Ins	INS	-	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:799980_799981insC	uc001lro.1	-	c.2308_2309insG	c.(2308-2310)GCTfs	p.A770fs	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_Non-coding_Transcript|LRDD_uc001lrk.1_Frame_Shift_Ins_p.A753fs|LRDD_uc001lrl.1_Frame_Shift_Ins_p.A613fs|LRDD_uc001lrm.1_Frame_Shift_Ins_p.A457fs|LRDD_uc001lrn.1_Frame_Shift_Ins_p.A613fs|LRDD_uc001lrp.1_Frame_Shift_Ins_p.G453fs	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	770					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)										0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	799980	799981	9309	11	-	C	C	C	442	34	LRDD	5	5
TCF7	6932	broad.mit.edu	37	5	133451679	133451680	+	Frame_Shift_Ins	INS	-	C	C			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:133451679_133451680insC	uc003kyt.2	+	c.396_397insC	c.(394-399)CCACCCfs	p.P132fs	TCF7_uc003kyu.1_Frame_Shift_Ins_p.P17fs|TCF7_uc003kyv.2_Frame_Shift_Ins_p.P17fs|TCF7_uc003kyw.2_Frame_Shift_Ins_p.P17fs|TCF7_uc003kyx.2_5'UTR|TCF7_uc003kyy.2_Frame_Shift_Ins_p.P17fs|TCF7_uc003kyz.2_Frame_Shift_Ins_p.P17fs|TCF7_uc003kza.2_Frame_Shift_Ins_p.P17fs	NM_003202	NP_003193	P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific,	132_133					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	promoter binding|protein binding|RNA polymerase II transcription factor activity				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)											0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	133451679	133451680	16222	5	-	C	C	C	67	6	TCF7	5	5
KIAA2026	158358	broad.mit.edu	37	9	5968043	5968044	+	Frame_Shift_Ins	INS	-	T	T			TCGA-44-2665-01	TCGA-44-2665-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:5968043_5968044insT	uc003zjq.3	-	c.2187_2188insA	c.(2185-2190)AAAGCAfs	p.K729fs		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	729_730	Lys-rich.									ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)										0.38			3	5		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	5968043	5968044	8581	9	-	T	T	T	364	28	KIAA2026	5	5
