Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
ATM	472	broad.mit.edu	37	11	108236107	108236107	+	Nonsense_Mutation	SNP	G	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:108236107G>T	uc001pkb.1	+	c.9043G>T	c.(9043-9045)GAG>TAG	p.E3015*	ATM_uc009yxr.1_Nonsense_Mutation_p.E3015*|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Nonsense_Mutation_p.E1667*	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3015					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(24)|breast(14)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	238		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)						1073	TSP Lung(14;0.12)			0.592593	123.481023	124.082117	48	33	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	108236107	108236107	1128	11	G	T	T	T	429	33	ATM	5	2
EXPH5	23086	broad.mit.edu	37	11	108383265	108383265	+	Missense_Mutation	SNP	T	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:108383265T>C	uc001pkk.2	-	c.2969A>G	c.(2968-2970)GAA>GGA	p.E990G	EXPH5_uc010rvy.1_Missense_Mutation_p.E802G|EXPH5_uc010rvz.1_Missense_Mutation_p.E834G|EXPH5_uc010rwa.1_Missense_Mutation_p.E914G	NM_015065	NP_055880	Q149M6	Q149M6_HUMAN	exophilin 5 isoform a	990					intracellular protein transport		Rab GTPase binding			ovary(2)	2		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)										0.201342	70.27127	82.627464	30	119	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	108383265	108383265	5516	11	T	C	C	C	806	62	EXPH5	4	4
CLEC9A	283420	broad.mit.edu	37	12	10213811	10213811	+	Missense_Mutation	SNP	G	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:10213811G>T	uc001qxa.2	+	c.258G>T	c.(256-258)AAG>AAT	p.K86N		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	86	Extracellular (Potential).					integral to membrane	receptor activity|sugar binding			ovary(1)	1														0.336957	67.875295	70.048909	31	61	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10213811	10213811	3660	12	G	T	T	T	425	33	CLEC9A	2	2
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:25398284C>T	uc001rgp.1	-	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_Non-coding_Transcript	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(6894)|p.G12V(4601)|p.G12A(1119)|p.G12?(50)|p.G12F(33)|p.G12N(6)|p.G12L(5)|p.G12C(4)|p.G12I(3)|p.G12W(3)|p.G12E(2)|p.G12Y(2)|p.G12fs*3(1)|p.G12S(1)|p.G12_G13insG(1)		large_intestine(11742)|pancreas(3256)|lung(2694)|biliary_tract(514)|ovary(437)|endometrium(339)|haematopoietic_and_lymphoid_tissue(303)|stomach(179)|thyroid(145)|prostate(85)|soft_tissue(75)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|breast(27)|liver(21)|testis(17)|oesophagus(15)|central_nervous_system(8)|peritoneum(5)|kidney(5)|salivary_gland(5)|thymus(5)|eye(4)|gastrointestinal_tract_(site_indeterminate)(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	20148	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	p.G12D(SNU1197-Tumor)|p.G12D(HEC1A-Tumor)|p.G12D(SKLU1-Tumor)|p.G12D(GP2D-Tumor)|p.G12A(MM1S-Tumor)|p.G12D(HCC1588-Tumor)|p.G12D(SNUC2A-Tumor)|p.G12D(SNU1033-Tumor)|p.G12A(KPNSI9S-Tumor)|p.G12A(NCIH1573-Tumor)|p.G12D(KARPAS620-Tumor)|p.G12D(KP1NL-Tumor)|p.G12D(MCAS-Tumor)|p.G12D(HPAFII-Tumor)|p.G12D(PANC04.03-Tumor)|p.G12D(PANC10.05-Tumor)|p.G12D(TGBC11TKB-Tumor)|p.G12D(LS513-Tumor)|p.G12D(SW1990-Tumor)|p.G12D(SNU601-Tumor)|p.G12A(COLO775-Tumor)|p.G12D(ASPC1-Tumor)|p.G12A(SW1116-Tumor)|p.G12D(CL40-Tumor)|p.G12D(HEC1B-Tumor)|p.G12D(LS180-Tumor)|p.G12D(HEYA8-Tumor)|p.G12D(KP1N-Tumor)|p.G12D(PK1-Tumor)|p.G12D(SU.86.86-Tumor)|p.G12A(RERFLCAD1-Tumor)|p.G12D(PANC08.13-Tumor)|p.G12D(HEC50B-Tumor)|p.G12A(NCIH2009-Tumor)|p.G12D(639V-Tumor)|p.G12D(SNU410-Tumor)|p.G12D(L3.3-Tumor)|p.G12D(SNU407-Tumor)|p.G12A(KMS28BM-Tumor)|p.G12D(PK59-Tumor)|p.G12V(SH10TC-Tumor)|p.G12D(PK45H-Tumor)|p.G12D(GSU-Tumor)|p.G12D(SNU869-Tumor)|p.G12D(HUCCT1-Tumor)|p.G12D(NCIH684-Tumor)|p.G12D(KP4-Tumor)|p.G12D(PANC02.03-Tumor)|p.G12A(RPMI8226-Tumor)|p.G12V(PANC03.27-Tumor)|p.G12D(SNU1-Tumor)|p.G12D(AGS-Tumor)|p.G12D(SNU8-Tumor)|p.G12D(T3M10-Tumor)	262	TSP Lung(1;<1E-8)|Multiple Myeloma(2;<1E-6)			0.5	31.067377	31.067377	12	12	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	25398284	25398284	8753	12	C	T	T	T	234	18	KRAS	2	2
BICD1	636	broad.mit.edu	37	12	32491750	32491750	+	Missense_Mutation	SNP	C	G	G			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:32491750C>G	uc001rku.2	+	c.2601C>G	c.(2599-2601)AGC>AGG	p.S867R	BICD1_uc001rkv.2_Intron|BICD1_uc010skd.1_Non-coding_Transcript	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	867					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)	1	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)											0.248082	273.87755	296.463461	97	294	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	32491750	32491750	1453	12	C	G	G	G	337	26	BICD1	3	3
KDM5A	5927	broad.mit.edu	37	12	442778	442778	+	Missense_Mutation	SNP	C	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:442778C>A	uc001qif.1	-	c.1528G>T	c.(1528-1530)GCT>TCT	p.A510S	KDM5A_uc001qie.1_Missense_Mutation_p.A510S|KDM5A_uc010sdn.1_Missense_Mutation_p.A469S|KDM5A_uc010sdo.1_Missense_Mutation_p.A129S	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	510	JmjC.				chromatin modification|multicellular organismal development|oxidation-reduction process|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|transcription activator activity|zinc ion binding			skin(2)|ovary(1)	3										958				0.420382	172.698477	173.572083	66	91	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	442778	442778	8439	12	C	A	A	A	325	25	KDM5A	2	2
TC2N	123036	broad.mit.edu	37	14	92268648	92268648	+	Nonsense_Mutation	SNP	A	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:92268648A>T	uc001xzu.3	-	c.419T>A	c.(418-420)TTG>TAG	p.L140*	TC2N_uc001xzt.3_Nonsense_Mutation_p.L140*|TC2N_uc010auc.2_Nonsense_Mutation_p.L140*|TC2N_uc001xzv.3_Nonsense_Mutation_p.L140*	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	140						nucleus					0				COAD - Colon adenocarcinoma(157;0.218)										0.653226	237.793262	240.366206	81	43	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	92268648	92268648	16191	14	A	T	T	T	65	5	TC2N	5	3
RFX7	64864	broad.mit.edu	37	15	56387452	56387452	+	Missense_Mutation	SNP	C	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:56387452C>A	uc010bfn.2	-	c.2474G>T	c.(2473-2475)GGA>GTA	p.G825V	RFX7_uc010ugk.1_Non-coding_Transcript|RFX7_uc002adn.1_Missense_Mutation_p.G639V	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	728					regulation of transcription, DNA-dependent	nucleus	DNA binding				0														0.431953	173.205668	173.894784	73	96	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	56387452	56387452	13740	15	C	A	A	A	390	30	RFX7	2	2
BBS2	583	broad.mit.edu	37	16	56545113	56545113	+	Silent	SNP	A	G	G			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:56545113A>G	uc002ejd.2	-	c.429T>C	c.(427-429)GCT>GCC	p.A143A	BBS2_uc010ccg.2_Silent_p.A143A	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	143					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1														0.259912	176.548504	188.377283	59	168	KEEP	---	---	---	---	capture		Silent	SNP	56545113	56545113	1359	16	A	G	G	G	132	11	BBS2	4	4
MYH1	4619	broad.mit.edu	37	17	10412919	10412919	+	Missense_Mutation	SNP	C	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:10412919C>A	uc002gmo.2	-	c.1470G>T	c.(1468-1470)CAG>CAT	p.Q490H		NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	490	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|breast(3)|kidney(1)|skin(1)	15										585				0.46875	206.886672	207.024213	75	85	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10412919	10412919	10424	17	C	A	A	A	259	20	MYH1	2	2
ZFP112	7771	broad.mit.edu	37	19	44847409	44847409	+	Silent	SNP	G	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:44847409G>A	uc010xwy.1	-	c.63C>T	c.(61-63)TTC>TTT	p.F21F	ZFP112_uc010ejj.2_Silent_p.F4F|ZFP112_uc002ozc.3_Intron|ZFP112_uc010xwz.1_Intron	NM_013380	NP_037512	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 2	4				KFQ -> VSK (in Ref. 1; AAF12816).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3						Melanoma(53;975 1202 7512 15993 27273)								0.27193	69.359047	74.717935	31	83	KEEP	---	---	---	---	capture		Silent	SNP	44847409	44847409	18226	19	G	A	A	A	529	41	ZFP112	2	2
CD160	11126	broad.mit.edu	37	1	145699074	145699074	+	Silent	SNP	T	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:145699074T>A	uc001eol.1	-	c.417A>T	c.(415-417)ACA>ACT	p.T139T	NBPF10_uc001emp.3_Intron|CD160_uc001eom.1_Silent_p.T30T|CD160_uc010oyz.1_Non-coding_Transcript	NM_007053	NP_008984	O95971	BY55_HUMAN	CD160 antigen precursor	139					cell proliferation|cell surface receptor linked signaling pathway|cellular defense response|regulation of immune response	anchored to plasma membrane	MHC class I receptor activity|receptor binding				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			Colon(182;1122 1999 4065 44014 53024)				68				0.301887	71.455334	75.174319	32	74	KEEP	---	---	---	---	capture		Silent	SNP	145699074	145699074	3093	1	T	A	A	A	704	55	CD160	3	3
OTUD7B	56957	broad.mit.edu	37	1	149936222	149936222	+	Silent	SNP	T	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:149936222T>C	uc001etn.2	-	c.657A>G	c.(655-657)GCA>GCG	p.A219A	OTUD7B_uc001eto.2_Silent_p.A140A	NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	219	Catalytic.|OTU.|TRAF-binding.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding				0	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)											0.410891	244.527775	245.915803	83	119	KEEP	---	---	---	---	capture		Silent	SNP	149936222	149936222	11732	1	T	C	C	C	756	59	OTUD7B	4	4
FMO4	2329	broad.mit.edu	37	1	171303668	171303668	+	Missense_Mutation	SNP	A	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:171303668A>T	uc001gho.2	+	c.946A>T	c.(946-948)ACA>TCA	p.T316S		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	316					oxidation-reduction process|xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					Pancreas(24;816 862 7754 7993 32832)				211				0.421622	196.300735	197.294443	78	107	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	171303668	171303668	6199	1	A	T	T	T	130	10	FMO4	3	3
WDR65	149465	broad.mit.edu	37	1	43650921	43650921	+	Missense_Mutation	SNP	T	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:43650921T>C	uc001cip.1	+	c.863T>C	c.(862-864)ATT>ACT	p.I288T	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Missense_Mutation_p.I277T|WDR65_uc001ciq.1_Missense_Mutation_p.I288T	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	288											0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)												0.373239	168.554178	170.551748	53	89	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43650921	43650921	17889	1	T	C	C	C	676	52	WDR65	4	4
BPI	671	broad.mit.edu	37	20	36952397	36952397	+	Silent	SNP	G	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:36952397G>A	uc002xib.2	+	c.894G>A	c.(892-894)GGG>GGA	p.G298G		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	298					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)												0.47619	77.934547	77.96615	30	33	KEEP	---	---	---	---	capture		Silent	SNP	36952397	36952397	1518	20	G	A	A	A	535	42	BPI	2	2
GNAS	2778	broad.mit.edu	37	20	57428785	57428785	+	Missense_Mutation	SNP	C	G	G			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:57428785C>G	uc002xzw.2	+	c.465C>G	c.(463-465)AGC>AGG	p.S155R	GNASAS_uc002xzs.1_5'Flank|GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_Non-coding_Transcript	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|large_intestine(5)|parathyroid(5)|kidney(5)|lung(2)|testis(1)|autonomic_ganglia(1)	279	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			Colon(117;935 1597 6045 8307 46442)				461	TSP Lung(22;0.16)			0.428571	34.473339	34.618307	12	16	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57428785	57428785	6779	20	C	G	G	G	338	26	GNAS	3	3
RANBP2	5903	broad.mit.edu	37	2	109381162	109381162	+	Silent	SNP	A	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:109381162A>T	uc002tem.3	+	c.4167A>T	c.(4165-4167)CCA>CCT	p.P1389P		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1389					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(14)	soft_tissue(14)|pancreas(1)	15														0.349398	243.798584	248.759101	87	162	KEEP	---	---	---	---	capture		Silent	SNP	109381162	109381162	13488	2	A	T	T	T	93	8	RANBP2	3	3
OSBPL6	114880	broad.mit.edu	37	2	179247751	179247751	+	Missense_Mutation	SNP	T	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:179247751T>C	uc002uly.2	+	c.1697T>C	c.(1696-1698)ATC>ACC	p.I566T	OSBPL6_uc002ulx.2_Missense_Mutation_p.I541T|OSBPL6_uc010zfe.1_Missense_Mutation_p.I510T|OSBPL6_uc002ulz.2_Missense_Mutation_p.I505T|OSBPL6_uc002uma.2_Missense_Mutation_p.I545T	NM_145739	NP_665682	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	541					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)											0.435644	146.493609	146.856234	44	57	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	179247751	179247751	11692	2	T	C	C	C	754	58	OSBPL6	4	4
ALMS1	7840	broad.mit.edu	37	2	73830395	73830395	+	Missense_Mutation	SNP	C	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:73830395C>T	uc002sje.1	+	c.12329C>T	c.(12328-12330)CCT>CTT	p.P4110L	ALMS1_uc002sjf.1_Missense_Mutation_p.P4066L|ALMS1_uc002sjh.1_Missense_Mutation_p.P3496L	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	4108					G2/M transition of mitotic cell cycle|visual perception	centrosome|cilium|cytosol|microtubule basal body|spindle pole				ovary(2)|breast(2)|lung(1)|pancreas(1)	6														0.361111	36.763448	37.375373	13	23	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	73830395	73830395	538	2	C	T	T	T	312	24	ALMS1	2	2
ALMS1	7840	broad.mit.edu	37	2	73830399	73830399	+	Missense_Mutation	SNP	C	G	G			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:73830399C>G	uc002sje.1	+	c.12333C>G	c.(12331-12333)ATC>ATG	p.I4111M	ALMS1_uc002sjf.1_Missense_Mutation_p.I4067M|ALMS1_uc002sjh.1_Missense_Mutation_p.I3497M	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	4109					G2/M transition of mitotic cell cycle|visual perception	centrosome|cilium|cytosol|microtubule basal body|spindle pole				ovary(2)|breast(2)|lung(1)|pancreas(1)	6														0.333333	38.315929	39.126785	11	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	73830399	73830399	538	2	C	G	G	G	369	29	ALMS1	3	3
REG1B	5968	broad.mit.edu	37	2	79314711	79314711	+	Missense_Mutation	SNP	G	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:79314711G>T	uc002sny.2	-	c.28C>A	c.(28-30)CTG>ATG	p.L10M	REG1B_uc010ffv.1_Missense_Mutation_p.L10M|REG1B_uc010ffw.2_Missense_Mutation_p.L10M	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	10					cell proliferation	extracellular region	sugar binding			central_nervous_system(1)	1														0.489362	62.21559	62.220404	23	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	79314711	79314711	13680	2	G	T	T	T	438	34	REG1B	2	2
CASR	846	broad.mit.edu	37	3	122002536	122002536	+	Missense_Mutation	SNP	G	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:122002536G>A	uc003eew.3	+	c.1765G>A	c.(1765-1767)GCC>ACC	p.A589T	CASR_uc003eev.3_Missense_Mutation_p.A579T	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	579	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)									0.155844	13.240846	21.96792	12	65	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	122002536	122002536	2801	3	G	A	A	A	598	46	CASR	2	2
CPB1	1360	broad.mit.edu	37	3	148562468	148562468	+	Missense_Mutation	SNP	G	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:148562468G>A	uc003ewl.2	+	c.692G>A	c.(691-693)CGA>CAA	p.R231Q		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	231					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)											0.653061	165.188754	167.210302	64	34	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	148562468	148562468	3934	3	G	A	A	A	481	37	CPB1	1	1
SLC7A14	57709	broad.mit.edu	37	3	170198379	170198379	+	Silent	SNP	C	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:170198379C>A	uc003fgz.2	-	c.1692G>T	c.(1690-1692)ACG>ACT	p.T564T	CLDN11_uc011bpt.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	564						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|liver(1)|central_nervous_system(1)	4	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)											0.73494	160.04135	164.158416	61	22	KEEP	---	---	---	---	capture		Silent	SNP	170198379	170198379	15193	3	C	A	A	A	288	23	SLC7A14	1	1
BAP1	8314	broad.mit.edu	37	3	52441235	52441235	+	Missense_Mutation	SNP	G	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:52441235G>A	uc003ddx.2	-	c.535C>T	c.(535-537)CGG>TGG	p.R179W	BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	179					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			eye(28)|lung(2)|ovary(1)|breast(1)	32				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GBM(101;493 1458 7992 21037 25532)				294				0.5	80.81031	80.81031	31	31	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	52441235	52441235	1332	3	G	A	A	A	506	39	BAP1	1	1
LARP1B	55132	broad.mit.edu	37	4	129043234	129043234	+	Missense_Mutation	SNP	C	G	G			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:129043234C>G	uc003iga.2	+	c.1415C>G	c.(1414-1416)TCT>TGT	p.S472C	LARP1B_uc003igc.2_5'UTR|LARP1B_uc003ifz.1_Missense_Mutation_p.S472C|LARP1B_uc003igb.1_Missense_Mutation_p.S187C	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	472							RNA binding				0														0.143713	50.182285	70.599657	24	143	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	129043234	129043234	8952	4	C	G	G	G	416	32	LARP1B	3	3
MAB21L2	10586	broad.mit.edu	37	4	151504477	151504477	+	Missense_Mutation	SNP	T	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:151504477T>C	uc003ilw.2	+	c.296T>C	c.(295-297)GTG>GCG	p.V99A	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	99					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)										0.191489	31.200407	39.589201	18	76	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	151504477	151504477	9519	4	T	C	C	C	767	59	MAB21L2	4	4
EIF4E	1977	broad.mit.edu	37	4	99802265	99802265	+	Missense_Mutation	SNP	G	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:99802265G>A	uc011ceb.1	-	c.661C>T	c.(661-663)CCT>TCT	p.P221S	EIF4E_uc011cea.1_Missense_Mutation_p.P210S|EIF4E_uc003hue.2_Missense_Mutation_p.P190S	NM_001130679	NP_001124151	P06730	IF4E_HUMAN	eukaryotic translation initiation factor 4E	190					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|interspecies interaction between organisms|mRNA export from nucleus|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mitotic cell cycle|regulation of translation	cytoplasmic mRNA processing body|cytosol|eukaryotic translation initiation factor 4F complex|mRNA cap binding complex|RNA-induced silencing complex	protein binding|RNA cap binding|translation initiation factor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)|LUSC - Lung squamous cell carcinoma(721;0.00227)						88				0.28125	38.411713	41.172525	18	46	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	99802265	99802265	5219	4	G	A	A	A	533	41	EIF4E	2	2
DTWD2	285605	broad.mit.edu	37	5	118183901	118183901	+	Missense_Mutation	SNP	T	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:118183901T>C	uc003ksa.2	-	c.610A>G	c.(610-612)ACT>GCT	p.T204A		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	204											0		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)										0.157143	27.28231	35.1288	11	59	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	118183901	118183901	4977	5	T	C	C	C	780	60	DTWD2	4	4
PCDHA6	56142	broad.mit.edu	37	5	140207997	140207997	+	Missense_Mutation	SNP	G	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140207997G>T	uc003lho.2	+	c.321G>T	c.(319-321)GAG>GAT	p.E107D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.E107D|PCDHA6_uc011dab.1_Missense_Mutation_p.E107D	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	107	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.371542	199.140143	202.819942	94	159	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	140207997	140207997	11948	5	G	T	T	T	451	35	PCDHA6	2	2
FBXL7	23194	broad.mit.edu	37	5	15928027	15928027	+	Missense_Mutation	SNP	C	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:15928027C>A	uc003jfn.1	+	c.156C>A	c.(154-156)AGC>AGA	p.S52R		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	52					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3														0.208333	42.468815	51.974338	25	95	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	15928027	15928027	5961	5	C	A	A	A	324	25	FBXL7	2	2
ADAMTS12	81792	broad.mit.edu	37	5	33616058	33616058	+	Nonsense_Mutation	SNP	C	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:33616058C>A	uc003jia.1	-	c.2263G>T	c.(2263-2265)GGA>TGA	p.G755*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.G670*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	755	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|lung(1)|kidney(1)|skin(1)	7														0.35567	159.985236	163.560233	69	125	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	33616058	33616058	258	5	C	A	A	A	273	21	ADAMTS12	5	2
OXCT1	5019	broad.mit.edu	37	5	41805723	41805723	+	Missense_Mutation	SNP	C	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:41805723C>A	uc003jmn.2	-	c.901G>T	c.(901-903)GTA>TTA	p.V301L		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	301					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2					Succinic acid(DB00139)									0.325153	146.217456	150.640006	53	110	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	41805723	41805723	11742	5	C	A	A	A	247	19	OXCT1	1	1
TRIM23	373	broad.mit.edu	37	5	64890374	64890374	+	Missense_Mutation	SNP	G	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:64890374G>C	uc003jty.2	-	c.1519C>G	c.(1519-1521)CTG>GTG	p.L507V	TRIM23_uc003jtw.2_Missense_Mutation_p.L507V|TRIM23_uc003jtx.2_Missense_Mutation_p.L507V	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	507	ARF-like.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)										0.363057	201.835282	204.425016	57	100	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	64890374	64890374	17041	5	G	C	C	C	425	33	TRIM23	3	3
CARTPT	9607	broad.mit.edu	37	5	71016433	71016433	+	Missense_Mutation	SNP	G	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:71016433G>C	uc003kbv.1	+	c.342G>C	c.(340-342)AAG>AAC	p.K114N		NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript	114					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)									0.333333	23.622559	24.136896	7	14	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	71016433	71016433	2778	5	G	C	C	C	464	36	CARTPT	3	3
TAAR8	83551	broad.mit.edu	37	6	132874425	132874425	+	Silent	SNP	G	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:132874425G>T	uc011ecj.1	+	c.594G>T	c.(592-594)GTG>GTT	p.V198V		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	198	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)										0.205128	51.827759	61.272245	24	93	KEEP	---	---	---	---	capture		Silent	SNP	132874425	132874425	16014	6	G	T	T	T	613	48	TAAR8	2	2
EPHB6	2051	broad.mit.edu	37	7	142564781	142564781	+	Missense_Mutation	SNP	G	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:142564781G>T	uc011kst.1	+	c.1705G>T	c.(1705-1707)GGC>TGC	p.G569C	EPHB6_uc011ksu.1_Missense_Mutation_p.G569C|EPHB6_uc003wbs.2_Missense_Mutation_p.G277C|EPHB6_uc003wbt.2_Missense_Mutation_p.G43C|EPHB6_uc003wbu.2_Missense_Mutation_p.G277C|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	569	Fibronectin type-III 2.|Extracellular (Potential).				protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|large_intestine(4)|central_nervous_system(3)|ovary(1)|pancreas(1)	14	Melanoma(164;0.059)								p.G554C(NCIH1339-Tumor)	313				0.183333	14.088669	19.760395	11	49	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	142564781	142564781	5371	7	G	T	T	T	507	39	EPHB6	1	1
HECW1	23072	broad.mit.edu	37	7	43484237	43484237	+	Missense_Mutation	SNP	A	G	G			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:43484237A>G	uc003tid.1	+	c.1466A>G	c.(1465-1467)GAG>GGG	p.E489G	HECW1_uc011kbi.1_Missense_Mutation_p.E489G	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	489	Glu-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(7)|breast(2)|skin(2)|pancreas(1)|lung(1)	13										944				0.48	40.000606	40.009161	12	13	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43484237	43484237	7325	7	A	G	G	G	143	11	HECW1	4	4
ZNF680	340252	broad.mit.edu	37	7	63982389	63982389	+	Missense_Mutation	SNP	T	C	C			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:63982389T>C	uc003tta.2	-	c.743A>G	c.(742-744)AAC>AGC	p.N248S	ZNF680_uc010kzr.2_Missense_Mutation_p.N175S	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	248	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)												0.352941	101.138015	102.753059	30	55	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	63982389	63982389	18682	7	T	C	C	C	780	60	ZNF680	4	4
ZFPM2	23414	broad.mit.edu	37	8	106813793	106813793	+	Missense_Mutation	SNP	G	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:106813793G>T	uc003ymd.2	+	c.1483G>T	c.(1483-1485)GGC>TGC	p.G495C	ZFPM2_uc011lhs.1_Missense_Mutation_p.G226C	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	495					blood coagulation|transcription, DNA-dependent	nucleoplasm	DNA binding|RNA polymerase II transcription factor activity|transcription corepressor activity|transcription repressor activity|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)											0.140449	46.591909	91.005576	50	306	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	106813793	106813793	18248	8	G	T	T	T	559	43	ZFPM2	2	2
CSMD3	114788	broad.mit.edu	37	8	113649131	113649131	+	Silent	SNP	C	T	T			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:113649131C>T	uc003ynu.2	-	c.3630G>A	c.(3628-3630)TCG>TCA	p.S1210S	CSMD3_uc003yns.2_Silent_p.S482S|CSMD3_uc003ynt.2_Silent_p.S1170S|CSMD3_uc011lhx.1_Silent_p.S1106S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1210	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(20)|lung(11)|kidney(8)|large_intestine(6)|skin(3)|central_nervous_system(2)|urinary_tract(1)|breast(1)	52										2888	TCGA Ovarian(7;0.080)			0.108	18.398122	56.454969	27	223	KEEP	---	---	---	---	capture		Silent	SNP	113649131	113649131	4087	8	C	T	T	T	288	23	CSMD3	1	1
OR13F1	138805	broad.mit.edu	37	9	107266550	107266550	+	Missense_Mutation	SNP	C	A	A			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:107266550C>A	uc011lvm.1	+	c.7C>A	c.(7-9)CCG>ACG	p.P3T		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2														0.407407	74.540325	75.151086	33	48	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	107266550	107266550	11347	9	C	A	A	A	286	22	OR13F1	2	2
CNTLN	54875	broad.mit.edu	37	9	17298270	17298270	+	Missense_Mutation	SNP	C	G	G			TCGA-49-4510-01	TCGA-49-4510-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:17298270C>G	uc003zmz.2	+	c.1066C>G	c.(1066-1068)CAG>GAG	p.Q356E	CNTLN_uc003zmx.3_Missense_Mutation_p.Q356E|CNTLN_uc003zmy.2_Missense_Mutation_p.Q356E|CNTLN_uc010mio.2_Missense_Mutation_p.Q35E	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	356						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)										0.65625	158.672819	160.054223	42	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	17298270	17298270	3777	9	C	G	G	G	377	29	CNTLN	3	3
