Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
ITGA8	8516	broad.mit.edu	37	10	15697389	15697389	+	Missense_Mutation	SNP	C	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:15697389C>A	uc001ioc.1	-	c.965G>T	c.(964-966)GGA>GTA	p.G322V	ITGA8_uc010qcb.1_Missense_Mutation_p.G307V	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	322	Extracellular (Potential).|FG-GAP 5.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6														0.147287	60.339618	91.142214	38	220	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	15697389	15697389	8186	10	C	A	A	A	390	30	ITGA8	2	2
GATA3	2625	broad.mit.edu	37	10	8106012	8106012	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:8106012G>A	uc001ijz.2	+	c.835G>A	c.(835-837)GGC>AGC	p.G279S	GATA3_uc001ika.2_Missense_Mutation_p.G278S	NM_001002295	NP_001002295	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 1	278	GATA-type 1.				blood coagulation|cell fate determination|defense response|mesonephros development|negative regulation of cell proliferation|nephric duct formation|norepinephrine biosynthetic process|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of interleukin-4 production|regulation of cytokine biosynthetic process|response to estrogen stimulus|signal transduction|sympathetic nervous system development|transcription from RNA polymerase II promoter|ureteric bud formation	nuclear chromatin|nucleolus|nucleoplasm	E-box binding|HMG box domain binding|sequence-specific DNA binding transcription factor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(2)|central_nervous_system(2)	21														0.2	18.932199	22.239621	8	32	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	8106012	8106012	6519	10	G	A	A	A	611	47	GATA3	2	2
C10orf12	26148	broad.mit.edu	37	10	98742267	98742267	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:98742267G>A	uc001kmv.2	+	c.1120G>A	c.(1120-1122)GAT>AAT	p.D374N	C10orf12_uc009xvg.1_Missense_Mutation_p.D684N	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	374											0		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)										0.081395	3.064929	18.404922	7	79	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	98742267	98742267	1624	10	G	A	A	A	429	33	C10orf12	2	2
OR51B5	282763	broad.mit.edu	37	11	5364346	5364346	+	Missense_Mutation	SNP	T	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:5364346T>A	uc001map.1	-	c.409A>T	c.(409-411)ACT>TCT	p.T137S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Missense_Mutation_p.T137S	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)										0.276596	107.471315	113.741071	39	102	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	5364346	5364346	11501	11	T	A	A	A	741	57	OR51B5	3	3
UHRF1BP1L	23074	broad.mit.edu	37	12	100466570	100466570	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:100466570G>A	uc001tgq.2	-	c.1429C>T	c.(1429-1431)CGT>TGT	p.R477C	UHRF1BP1L_uc001tgr.2_Missense_Mutation_p.R477C|UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.R127C	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	477										ovary(1)	1														0.198238	104.878881	124.112245	45	182	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100466570	100466570	17527	12	G	A	A	A	481	37	UHRF1BP1L	1	1
TULP3	7289	broad.mit.edu	37	12	3047432	3047432	+	Silent	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:3047432G>A	uc001qlj.2	+	c.1176G>A	c.(1174-1176)CAG>CAA	p.Q392Q	TULP3_uc009zec.1_Silent_p.Q119Q|TULP3_uc010seg.1_Non-coding_Transcript|TULP3_uc010seh.1_Silent_p.Q392Q|TULP3_uc010sei.1_Silent_p.Q216Q	NM_001160408	NP_001153880	O75386	TULP3_HUMAN	tubby like protein 3 isoform 2	392					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)											0.077922	-1.086813	12.926898	6	71	KEEP	---	---	---	---	capture		Silent	SNP	3047432	3047432	17330	12	G	A	A	A	425	33	TULP3	2	2
CNOT2	4848	broad.mit.edu	37	12	70704789	70704789	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:70704789G>A	uc001svv.2	+	c.163G>A	c.(163-165)GAA>AAA	p.E55K	CNOT2_uc009zro.2_Missense_Mutation_p.E55K|CNOT2_uc009zrp.2_Missense_Mutation_p.E35K|CNOT2_uc009zrq.2_Missense_Mutation_p.E55K	NM_014515	NP_055330	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	55					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter, global|transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA polymerase II transcription mediator activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)											0.061728	-13.725233	34.92339	15	228	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	70704789	70704789	3757	12	G	A	A	A	429	33	CNOT2	2	2
RCBTB2	1102	broad.mit.edu	37	13	49076005	49076005	+	Splice_Site_SNP	SNP	C	T	T			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:49076005C>T	uc010tgg.1	-	c.1133_splice	c.e11-1	p.E378_splice	RCBTB2_uc001vch.2_Splice_Site_SNP_p.E373_splice|RCBTB2_uc001vci.2_Splice_Site_SNP_p.E349_splice|RCBTB2_uc010tgh.1_Splice_Site_SNP_p.E99_splice|RCBTB2_uc001vcj.2_Splice_Site_SNP_p.E325_splice|RCBTB2_uc010acv.1_Splice_Site_SNP	NM_001268	NP_001259			regulator of chromosome condensation and BTB								Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)	4		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)						264				0.112903	8.483724	17.65332	7	55	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	49076005	49076005	13641	13	C	T	T	T	416	32	RCBTB2	5	2
ADAM21	8747	broad.mit.edu	37	14	70924778	70924778	+	Missense_Mutation	SNP	G	C	C			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:70924778G>C	uc001xmd.2	+	c.562G>C	c.(562-564)GAA>CAA	p.E188Q		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	188					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)	1				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)										0.11215	12.222518	28.151987	12	95	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	70924778	70924778	244	14	G	C	C	C	585	45	ADAM21	3	3
DLL4	54567	broad.mit.edu	37	15	41224584	41224584	+	Silent	SNP	C	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:41224584C>A	uc001zng.1	+	c.789C>A	c.(787-789)ACC>ACA	p.T263T		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	263	EGF-like 2.|Extracellular (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding				0		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)						135				0.428571	9.024528	9.055506	3	4	KEEP	---	---	---	---	capture		Silent	SNP	41224584	41224584	4748	15	C	A	A	A	301	24	DLL4	2	2
LMAN1L	79748	broad.mit.edu	37	15	75115013	75115013	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:75115013G>A	uc002ayt.1	+	c.1162G>A	c.(1162-1164)GGA>AGA	p.G388R	LMAN1L_uc010bke.1_Missense_Mutation_p.G376R	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	388	Lumenal (Potential).					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0														0.222222	16.535861	18.452	6	21	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	75115013	75115013	9166	15	G	A	A	A	611	47	LMAN1L	2	2
MAN2A2	4122	broad.mit.edu	37	15	91449666	91449666	+	Silent	SNP	C	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:91449666C>G	uc010bnz.2	+	c.774C>G	c.(772-774)TCC>TCG	p.S258S	MAN2A2_uc010boa.2_Silent_p.S300S|MAN2A2_uc002bqc.2_Silent_p.S258S|MAN2A2_uc010uql.1_5'Flank|MAN2A2_uc010uqm.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	258	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)											0.30303	21.231089	22.378203	10	23	KEEP	---	---	---	---	capture		Silent	SNP	91449666	91449666	9598	15	C	G	G	G	275	22	MAN2A2	3	3
GRIN2A	2903	broad.mit.edu	37	16	9858028	9858028	+	Nonsense_Mutation	SNP	C	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:9858028C>A	uc002czo.3	-	c.3373G>T	c.(3373-3375)GAG>TAG	p.E1125*	GRIN2A_uc010uym.1_Nonsense_Mutation_p.E1125*|GRIN2A_uc010uyn.1_Nonsense_Mutation_p.E968*|GRIN2A_uc002czr.3_Nonsense_Mutation_p.E1125*	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1125	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)					324				0.081633	-20.400061	41.577586	28	315	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	9858028	9858028	7058	16	C	A	A	A	390	30	GRIN2A	5	2
CDK12	51755	broad.mit.edu	37	17	37619172	37619172	+	Missense_Mutation	SNP	C	T	T			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:37619172C>T	uc010cvv.2	+	c.848C>T	c.(847-849)TCG>TTG	p.S283L	CDK12_uc010wef.1_Missense_Mutation_p.S283L|CDK12_uc002hrw.3_Missense_Mutation_p.S283L	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	283					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity|RNA polymerase II transcription factor activity			ovary(8)|lung(2)|large_intestine(1)	11										277	TCGA Ovarian(9;0.13)			0.118644	7.614387	16.028122	7	52	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	37619172	37619172	3257	17	C	T	T	T	403	31	CDK12	1	1
MTMR4	9110	broad.mit.edu	37	17	56573109	56573109	+	Missense_Mutation	SNP	C	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:56573109C>A	uc002iwj.2	-	c.2394G>T	c.(2392-2394)ATG>ATT	p.M798I		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	798						cytoplasm|membrane	protein tyrosine phosphatase activity|zinc ion binding			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)													0.123596	12.072035	24.404395	11	78	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	56573109	56573109	10339	17	C	A	A	A	325	25	MTMR4	2	2
OR1M1	125963	broad.mit.edu	37	19	9204692	9204692	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:9204692G>A	uc010xkj.1	+	c.772G>A	c.(772-774)GTC>ATC	p.V258I		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0														0.165829	57.368202	78.407986	33	166	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	9204692	9204692	11374	19	G	A	A	A	520	40	OR1M1	1	1
ZNF687	57592	broad.mit.edu	37	1	151260444	151260444	+	Missense_Mutation	SNP	C	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:151260444C>G	uc001exq.2	+	c.1677C>G	c.(1675-1677)ATC>ATG	p.I559M	ZNF687_uc001exp.1_Missense_Mutation_p.I568M|ZNF687_uc009wmo.2_Missense_Mutation_p.I559M|ZNF687_uc009wmp.2_Missense_Mutation_p.I559M	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)											0.456522	61.459356	61.53538	21	25	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	151260444	151260444	18687	1	C	G	G	G	395	31	ZNF687	3	3
ARHGEF2	9181	broad.mit.edu	37	1	155932776	155932776	+	Missense_Mutation	SNP	C	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:155932776C>A	uc001fmu.2	-	c.1055G>T	c.(1054-1056)GGC>GTC	p.G352V	ARHGEF2_uc001fmr.2_Missense_Mutation_p.G280V|ARHGEF2_uc001fms.2_Missense_Mutation_p.G307V|ARHGEF2_uc001fmt.2_Missense_Mutation_p.G308V|ARHGEF2_uc010pgt.1_Missense_Mutation_p.G281V|ARHGEF2_uc010pgu.1_Missense_Mutation_p.G353V	NM_004723	NP_004714	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	308	DH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					Melanoma(178;35 2768 6610 28839)								0.28	29.713848	31.902716	14	36	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	155932776	155932776	917	1	C	A	A	A	338	26	ARHGEF2	2	2
PDC	5132	broad.mit.edu	37	1	186413131	186413131	+	Nonsense_Mutation	SNP	C	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:186413131C>A	uc001gsa.2	-	c.721G>T	c.(721-723)GAA>TAA	p.E241*	PDC_uc001grz.2_Nonsense_Mutation_p.E189*	NM_002597	NP_002588	P20941	PHOS_HUMAN	phosducin isoform a	241					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity				0		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)										0.043662	-98.891532	59.873899	31	679	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	186413131	186413131	12035	1	C	A	A	A	416	32	PDC	5	2
PIK3C2B	5287	broad.mit.edu	37	1	204410669	204410669	+	Missense_Mutation	SNP	T	C	C			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:204410669T>C	uc001haw.2	-	c.3179A>G	c.(3178-3180)AAT>AGT	p.N1060S	PIK3C2B_uc010pqv.1_Missense_Mutation_p.N1032S	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1060					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|central_nervous_system(1)	3	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)							466				0.168421	32.429911	42.343659	16	79	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	204410669	204410669	12334	1	T	C	C	C	676	52	PIK3C2B	4	4
BAI2	576	broad.mit.edu	37	1	32207725	32207725	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:32207725G>A	uc001btn.2	-	c.1346C>T	c.(1345-1347)GCG>GTG	p.A449V	BAI2_uc010ogo.1_Missense_Mutation_p.A91V|BAI2_uc010ogp.1_Missense_Mutation_p.A382V|BAI2_uc010ogq.1_Missense_Mutation_p.A449V|BAI2_uc001bto.2_Missense_Mutation_p.A449V|BAI2_uc001btq.1_Missense_Mutation_p.A382V|BAI2_uc010ogr.1_Missense_Mutation_p.A382V	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	449	TSP type-1 3.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)										0.461538	17.631938	17.65003	6	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	32207725	32207725	1320	1	G	A	A	A	494	38	BAI2	1	1
TP73	7161	broad.mit.edu	37	1	3599647	3599647	+	Missense_Mutation	SNP	A	C	C			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:3599647A>C	uc001akp.2	+	c.89A>C	c.(88-90)GAC>GCC	p.D30A	TP73_uc001akq.2_Missense_Mutation_p.D30A	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	30	Asp/Glu-rich (acidic).|Transactivation (By similarity).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene-specific transcription from RNA polymerase II promoter|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|promoter binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription activator activity|transcription factor binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)						1049				0.285714	6.348823	6.636199	2	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	3599647	3599647	16937	1	A	C	C	C	130	10	TP73	4	4
AGRN	375790	broad.mit.edu	37	1	957721	957721	+	Silent	SNP	C	T	T			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:957721C>T	uc001ack.1	+	c.342C>T	c.(340-342)ATC>ATT	p.I114I		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	114	NtA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)										0.272727	9.52238	10.033037	3	8	KEEP	---	---	---	---	capture		Silent	SNP	957721	957721	400	1	C	T	T	T	408	32	AGRN	2	2
C20orf26	26074	broad.mit.edu	37	20	20322542	20322542	+	Missense_Mutation	SNP	C	T	T			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:20322542C>T	uc002wru.2	+	c.3490C>T	c.(3490-3492)CGC>TGC	p.R1164C	C20orf26_uc002wrw.2_Non-coding_Transcript	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	1164										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)										0.153846	5.086167	8.083001	4	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20322542	20322542	2186	20	C	T	T	T	247	19	C20orf26	1	1
SPO11	23626	broad.mit.edu	37	20	55909089	55909089	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:55909089G>A	uc002xye.2	+	c.448G>A	c.(448-450)GTC>ATC	p.V150I	SPO11_uc002xyf.2_Missense_Mutation_p.V112I	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	150					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)											0.288889	39.96245	41.757094	13	32	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	55909089	55909089	15590	20	G	A	A	A	520	40	SPO11	1	1
LCA5L	150082	broad.mit.edu	37	21	40778294	40778294	+	Silent	SNP	G	T	T			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:40778294G>T	uc002yxu.2	-	c.1527C>A	c.(1525-1527)GGC>GGA	p.G509G	LCA5L_uc002yxv.2_Silent_p.G509G	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	509											0		Prostate(19;1.2e-06)												0.142857	11.955412	17.926551	7	42	KEEP	---	---	---	---	capture		Silent	SNP	40778294	40778294	8980	21	G	T	T	T	587	46	LCA5L	2	2
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:44524456G>A	uc002zda.1	-	c.101C>T	c.(100-102)TCT>TTT	p.S34F	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.S34F|U2AF1_uc010gpi.1_Missense_Mutation_p.S34F|U2AF1_uc002zdc.1_Missense_Mutation_p.S34F	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	34	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0														0.368421	46.24641	46.82214	14	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	44524456	44524456	17378	21	G	A	A	A	429	33	U2AF1	2	2
GGT1	2678	broad.mit.edu	37	22	25010819	25010819	+	Missense_Mutation	SNP	C	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:25010819C>G	uc003aan.1	+	c.241C>G	c.(241-243)CAC>GAC	p.H81D	GGT1_uc003aas.1_Missense_Mutation_p.H81D|GGT1_uc003aat.1_Missense_Mutation_p.H81D|GGT1_uc003aau.1_Missense_Mutation_p.H81D|GGT1_uc003aav.1_Missense_Mutation_p.H81D|GGT1_uc003aaw.1_Missense_Mutation_p.H81D|GGT1_uc003aax.1_Missense_Mutation_p.H81D	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	81	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)									0.290323	21.653112	22.881256	9	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	25010819	25010819	6629	22	C	G	G	G	273	21	GGT1	3	3
SCTR	6344	broad.mit.edu	37	2	120209616	120209616	+	Missense_Mutation	SNP	G	C	C			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:120209616G>C	uc002tma.2	-	c.891C>G	c.(889-891)ATC>ATG	p.I297M	SCTR_uc002tlz.2_Missense_Mutation_p.I119M	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	297	Helical; Name=5; (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)	1					Secretin(DB00021)									0.205128	19.544221	22.642727	8	31	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	120209616	120209616	14426	2	G	C	C	C	577	45	SCTR	3	3
LRP1B	53353	broad.mit.edu	37	2	141072616	141072616	+	Missense_Mutation	SNP	C	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:141072616C>G	uc002tvj.1	-	c.12693G>C	c.(12691-12693)GAG>GAC	p.E4231D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4231	Extracellular (Potential).|EGF-like 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|ovary(10)|pancreas(3)|central_nervous_system(2)|liver(1)|kidney(1)	34		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		Colon(99;50 2074 2507 20106)				2546	TSP Lung(27;0.18)			0.054054	-15.996058	22.787429	10	175	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	141072616	141072616	9328	2	C	G	G	G	415	32	LRP1B	3	3
DNAH7	56171	broad.mit.edu	37	2	196664038	196664038	+	Silent	SNP	T	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:196664038T>A	uc002utj.3	-	c.10335A>T	c.(10333-10335)CTA>CTT	p.L3445L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3445	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(2)	2														0.222826	186.633776	212.630478	82	286	KEEP	---	---	---	---	capture		Silent	SNP	196664038	196664038	4789	2	T	A	A	A	782	61	DNAH7	3	3
CAPN10	11132	broad.mit.edu	37	2	241531406	241531406	+	Missense_Mutation	SNP	A	C	C			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:241531406A>C	uc002vzk.1	+	c.527A>C	c.(526-528)GAC>GCC	p.D176A	CAPN10_uc010zoh.1_Missense_Mutation_p.D176A|CAPN10_uc002vzl.1_Missense_Mutation_p.D176A|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Missense_Mutation_p.D48A|CAPN10_uc002vzo.1_Non-coding_Transcript|CAPN10_uc010fzg.1_Non-coding_Transcript|CAPN10_uc002vzp.1_Non-coding_Transcript|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	176	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)										0.333333	6.448529	6.595868	2	4	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	241531406	241531406	2740	2	A	C	C	C	130	10	CAPN10	4	4
CCT4	10575	broad.mit.edu	37	2	62104098	62104098	+	Missense_Mutation	SNP	T	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:62104098T>G	uc002sbo.2	-	c.734A>C	c.(733-735)AAG>ACG	p.K245T	CCT4_uc010ypp.1_Missense_Mutation_p.K189T|CCT4_uc010ypq.1_Missense_Mutation_p.K95T|CCT4_uc010ypr.1_Missense_Mutation_p.K189T|CCT4_uc010yps.1_Missense_Mutation_p.K215T	NM_006430	NP_006421	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	245					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding			ovary(2)	2	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)											0.163934	33.620657	46.717103	20	102	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	62104098	62104098	3082	2	T	G	G	G	728	56	CCT4	4	4
TBC1D23	55773	broad.mit.edu	37	3	100009497	100009497	+	Silent	SNP	T	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:100009497T>G	uc003dtt.2	+	c.552T>G	c.(550-552)TCT>TCG	p.S184S	TBC1D23_uc003dts.2_Silent_p.S184S	NM_018309	NP_060779	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	184	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)|liver(1)	2														0.108696	5.440249	19.538203	10	82	KEEP	---	---	---	---	capture		Silent	SNP	100009497	100009497	16135	3	T	G	G	G	717	56	TBC1D23	4	4
ATP2B2	491	broad.mit.edu	37	3	10401606	10401606	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:10401606G>A	uc003bvt.2	-	c.1861C>T	c.(1861-1863)CGC>TGC	p.R621C	ATP2B2_uc003bvv.2_Missense_Mutation_p.R576C|ATP2B2_uc003bvw.2_Missense_Mutation_p.R576C|ATP2B2_uc010hdo.2_Missense_Mutation_p.R326C	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	621	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|central_nervous_system(1)	4						Ovarian(125;1619 1709 15675 19819 38835)								0.534483	201.027976	201.1591	62	54	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10401606	10401606	1159	3	G	A	A	A	507	39	ATP2B2	1	1
SEC61A1	29927	broad.mit.edu	37	3	127785935	127785935	+	Nonsense_Mutation	SNP	C	T	T			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:127785935C>T	uc003ekb.2	+	c.916C>T	c.(916-918)CAA>TAA	p.Q306*	RUVBL1_uc003eke.2_Intron|RUVBL1_uc003ekf.2_Intron|SEC61A1_uc003ekc.2_Nonsense_Mutation_p.Q253*|SEC61A1_uc003ekd.2_Nonsense_Mutation_p.Q186*|SEC61A1_uc003ekg.2_5'UTR	NM_013336	NP_037468	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit	306	Helical; (Potential).				protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			ovary(1)	1														0.22	59.310844	66.519629	22	78	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	127785935	127785935	14486	3	C	T	T	T	273	21	SEC61A1	5	2
MTTP	4547	broad.mit.edu	37	4	100532564	100532564	+	Missense_Mutation	SNP	T	C	C			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:100532564T>C	uc011cej.1	+	c.2024T>C	c.(2023-2025)CTG>CCG	p.L675P	MTTP_uc003hvc.3_Missense_Mutation_p.L648P	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	648	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)									0.334821	192.987947	198.429957	75	149	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100532564	100532564	10357	4	T	C	C	C	715	55	MTTP	4	4
TACR3	6870	broad.mit.edu	37	4	104640578	104640578	+	Silent	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:104640578G>A	uc003hxe.1	-	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	85	Helical; Name=1; (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)										0.106977	21.603353	54.60499	23	192	KEEP	---	---	---	---	capture		Silent	SNP	104640578	104640578	16028	4	G	A	A	A	473	37	TACR3	1	1
PCDHGA11	56105	broad.mit.edu	37	5	140801620	140801620	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140801620G>A	uc003lkq.1	+	c.826G>A	c.(826-828)GGG>AGG	p.G276R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.G276R|PCDHGA11_uc003lkp.1_Missense_Mutation_p.G276R	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	276	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.169355	47.913415	60.731347	21	103	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	140801620	140801620	11972	5	G	A	A	A	507	39	PCDHGA11	1	1
WWC1	23286	broad.mit.edu	37	5	167850949	167850949	+	Silent	SNP	C	T	T			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:167850949C>T	uc011den.1	+	c.1686C>T	c.(1684-1686)CTC>CTT	p.L562L	WWC1_uc003lzv.2_Silent_p.L562L|WWC1_uc003lzu.2_Silent_p.L562L|WWC1_uc003lzw.2_Silent_p.L361L	NM_001161661	NP_001155133	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 1	562					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|breast(1)	3	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)										0.153846	20.348122	29.287548	12	66	KEEP	---	---	---	---	capture		Silent	SNP	167850949	167850949	17985	5	C	T	T	T	366	29	WWC1	2	2
BDP1	55814	broad.mit.edu	37	5	70837459	70837459	+	Missense_Mutation	SNP	A	C	C			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:70837459A>C	uc003kbp.1	+	c.6201A>C	c.(6199-6201)AGA>AGC	p.R2067S	BDP1_uc003kbo.2_Missense_Mutation_p.R2067S|BDP1_uc003kbq.1_Non-coding_Transcript|BDP1_uc003kbr.1_Non-coding_Transcript	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2067					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding				0		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)										0.195652	17.841743	21.825337	9	37	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	70837459	70837459	1417	5	A	C	C	C	141	11	BDP1	4	4
FBXO30	84085	broad.mit.edu	37	6	146126568	146126568	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:146126568G>A	uc003qla.2	-	c.974C>T	c.(973-975)TCA>TTA	p.S325L		NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	325							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)										0.346535	203.908195	208.098885	70	132	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	146126568	146126568	5977	6	G	A	A	A	585	45	FBXO30	2	2
PPP1R10	5514	broad.mit.edu	37	6	30574350	30574350	+	Missense_Mutation	SNP	C	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:30574350C>G	uc003nqn.1	-	c.529G>C	c.(529-531)GAG>CAG	p.E177Q	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	177	Interaction with TOX4 (By similarity).				protein import into nucleus	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|transcription regulator activity|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4														0.0625	-8.284081	17.236742	8	120	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	30574350	30574350	12787	6	C	G	G	G	416	32	PPP1R10	3	3
HTR1B	3351	broad.mit.edu	37	6	78172847	78172847	+	Missense_Mutation	SNP	C	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:78172847C>A	uc003pil.1	-	c.274G>T	c.(274-276)GCG>TCG	p.A92S		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	92	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)									0.232143	32.947257	36.626186	13	43	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	78172847	78172847	7737	6	C	A	A	A	338	26	HTR1B	2	2
SNAP91	9892	broad.mit.edu	37	6	84270599	84270599	+	Missense_Mutation	SNP	C	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:84270599C>G	uc011dze.1	-	c.2510G>C	c.(2509-2511)GGA>GCA	p.G837A	SNAP91_uc011dzd.1_Missense_Mutation_p.G335A|SNAP91_uc003pkb.2_Missense_Mutation_p.G746A|SNAP91_uc003pkc.2_Missense_Mutation_p.G807A|SNAP91_uc003pkd.2_Missense_Mutation_p.G530A|SNAP91_uc003pka.2_Missense_Mutation_p.G835A	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	837	Pro-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)										0.113636	22.141767	41.566957	15	117	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	84270599	84270599	15333	6	C	G	G	G	390	30	SNAP91	3	3
COG5	10466	broad.mit.edu	37	7	107013191	107013191	+	Silent	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:107013191G>A	uc003vec.2	-	c.777C>T	c.(775-777)GTC>GTT	p.V259V	COG5_uc003ved.2_Silent_p.V259V|COG5_uc003vee.2_Silent_p.V259V	NM_006348	NP_006339	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	259					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)	2														0.209877	42.938647	49.24178	17	64	KEEP	---	---	---	---	capture		Silent	SNP	107013191	107013191	3799	7	G	A	A	A	470	37	COG5	1	1
LRGUK	136332	broad.mit.edu	37	7	133943059	133943059	+	Missense_Mutation	SNP	C	T	T			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:133943059C>T	uc003vrm.1	+	c.2249C>T	c.(2248-2250)CCG>CTG	p.P750L		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	750							ATP binding|kinase activity			lung(2)|kidney(1)|skin(1)	4										973				0.079096	-0.384492	31.577092	14	163	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	133943059	133943059	9316	7	C	T	T	T	299	23	LRGUK	1	1
SCRN1	9805	broad.mit.edu	37	7	30008662	30008662	+	Missense_Mutation	SNP	A	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:30008662A>G	uc011kaa.1	-	c.82T>C	c.(82-84)TAC>CAC	p.Y28H	SCRN1_uc011jzy.1_Intron|SCRN1_uc003tak.2_Missense_Mutation_p.Y8H|SCRN1_uc011jzz.1_Missense_Mutation_p.Y8H|SCRN1_uc010kvp.2_Missense_Mutation_p.Y8H|SCRN1_uc011jzx.1_Intron	NM_001145514	NP_001138986	Q12765	SCRN1_HUMAN	secernin 1 isoform b	8					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2														0.440476	104.924853	105.189071	37	47	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	30008662	30008662	14420	7	A	G	G	G	169	13	SCRN1	4	4
STAG3	10734	broad.mit.edu	37	7	99796183	99796183	+	Missense_Mutation	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:99796183G>A	uc003utx.1	+	c.1330G>A	c.(1330-1332)GCA>ACA	p.A444T	STAG3_uc010lgs.1_Missense_Mutation_p.A232T|STAG3_uc011kjk.1_Missense_Mutation_p.A386T|STAG3_uc003uub.1_5'Flank	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	444					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(3)|skin(2)|lung(1)|kidney(1)	7	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)									331				0.175926	33.636968	44.402967	19	89	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	99796183	99796183	15762	7	G	A	A	A	494	38	STAG3	1	1
ST18	9705	broad.mit.edu	37	8	53071617	53071617	+	Silent	SNP	G	A	A			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:53071617G>A	uc003xqz.2	-	c.1647C>T	c.(1645-1647)GGC>GGT	p.G549G	ST18_uc011ldq.1_Silent_p.G196G|ST18_uc011ldr.1_Silent_p.G514G|ST18_uc011lds.1_Silent_p.G454G|ST18_uc003xra.2_Silent_p.G549G|ST18_uc003xrb.2_Silent_p.G549G	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	549						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)												0.278146	96.267774	102.985284	42	109	KEEP	---	---	---	---	capture		Silent	SNP	53071617	53071617	15730	8	G	A	A	A	483	38	ST18	1	1
GPM6B	2824	broad.mit.edu	37	X	13825830	13825830	+	Missense_Mutation	SNP	C	G	G			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:13825830C>G	uc004cvw.2	-	c.120G>C	c.(118-120)AAG>AAC	p.K40N	GPM6B_uc004cvx.2_Intron|GPM6B_uc011min.1_Intron|GPM6B_uc004cwa.2_Intron|GPM6B_uc011mim.1_Missense_Mutation_p.K14N|GPM6B_uc004cvy.2_Missense_Mutation_p.K40N|GPM6B_uc004cvz.2_Intron	NM_001001995	NP_001001995	Q13491	GPM6B_HUMAN	glycoprotein M6B isoform 1	20					cell differentiation|nervous system development	integral to membrane					0														0.126316	19.030669	31.894115	12	83	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	13825830	13825830	6890	23	C	G	G	G	415	32	GPM6B	3	3
JHDM1D	80853	broad.mit.edu	37	7	139791810	139791810	+	Frame_Shift_Del	DEL	C	-	-			TCGA-64-1680-01	TCGA-64-1680-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:139791810_139791810delC	uc003vvm.2	-	c.2525_2525delG	c.(2524-2526)AGTfs	p.S842fs	JHDM1D_uc010lng.2_Non-coding_Transcript	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	842					midbrain development|oxidation-reduction process|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)													0.32			53	115		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	139791810	139791810	8252	7	C	-	-	-	260	20	JHDM1D	5	5
