Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
PNLIPRP2	5408	broad.mit.edu	37	10	118386480	118386480	+	Nonsense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:118386480G>T	uc001lcq.2	+	c.439G>T	c.(439-441)GAG>TAG	p.E147*	PNLIPRP2_uc009xyu.1_Non-coding_Transcript|PNLIPRP2_uc009xyv.1_Non-coding_Transcript	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	146					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)										0.833333	15.379935	16.009335	5	1	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	118386480	118386480	12577	10	G	T	T	T	533	41	PNLIPRP2	5	2
C10orf84	63877	broad.mit.edu	37	10	120095077	120095077	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:120095077C>T	uc001ldo.2	-	c.311G>A	c.(310-312)CGC>CAC	p.R104H	C10orf84_uc010qss.1_Missense_Mutation_p.R104H	NM_022063	NP_071346	Q9H8W3	CJ084_HUMAN	hypothetical protein LOC63877	104										ovary(1)	1		Colorectal(252;0.101)		all cancers(201;0.0244)										0.647059	66.075338	66.743247	22	12	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	120095077	120095077	1658	10	C	T	T	T	351	27	C10orf84	1	1
CUBN	8029	broad.mit.edu	37	10	16982064	16982064	+	Missense_Mutation	SNP	T	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:16982064T>C	uc001ioo.2	-	c.5515A>G	c.(5515-5517)AGC>GGC	p.S1839G		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1839	CUB 12.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)	18					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)					2704				0.748387	374.852569	383.499944	116	39	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	16982064	16982064	4211	10	T	C	C	C	715	55	CUBN	4	4
ARHGAP21	57584	broad.mit.edu	37	10	24874156	24874156	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:24874156G>A	uc001isb.2	-	c.5062C>T	c.(5062-5064)CGG>TGG	p.R1688W	ARHGAP21_uc010qdb.1_Non-coding_Transcript	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1687	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8														0.298246	48.068282	50.133351	17	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	24874156	24874156	882	10	G	A	A	A	506	39	ARHGAP21	1	1
ZEB1	6935	broad.mit.edu	37	10	31815998	31815998	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:31815998G>T	uc001ivu.3	+	c.3184G>T	c.(3184-3186)GGG>TGG	p.G1062W	ZEB1_uc001ivr.3_Missense_Mutation_p.G843W|ZEB1_uc010qee.1_Missense_Mutation_p.G843W|ZEB1_uc010qef.1_Missense_Mutation_p.G843W|ZEB1_uc001ivs.3_Missense_Mutation_p.G1061W|ZEB1_uc001ivt.3_Missense_Mutation_p.G843W|ZEB1_uc001ivv.3_Missense_Mutation_p.G1041W|ZEB1_uc010qeh.1_Missense_Mutation_p.G994W|ZEB1_uc009xlp.2_Missense_Mutation_p.G1045W	NM_030751	NP_001121600	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	1061	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription repressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				Ovarian(40;423 959 14296 36701 49589)								0.666667	30.547809	30.914958	10	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	31815998	31815998	18211	10	G	T	T	T	455	35	ZEB1	2	2
ZNF33A	7581	broad.mit.edu	37	10	38343661	38343661	+	Silent	SNP	T	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:38343661T>C	uc010qev.1	+	c.627T>C	c.(625-627)CAT>CAC	p.H209H	ZNF33A_uc001izg.2_Silent_p.H203H|ZNF33A_uc001izh.2_Silent_p.H202H|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	202					regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3														0.22619	44.481432	50.26494	19	65	KEEP	---	---	---	---	capture		Silent	SNP	38343661	38343661	18446	10	T	C	C	C	660	51	ZNF33A	4	4
MMP13	4322	broad.mit.edu	37	11	102816458	102816458	+	Missense_Mutation	SNP	A	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:102816458A>G	uc001phl.2	-	c.1232T>C	c.(1231-1233)ATT>ACT	p.I411T		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	411	Hemopexin-like 3.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)										0.3	54.928882	57.071708	18	42	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	102816458	102816458	10042	11	A	G	G	G	52	4	MMP13	4	4
DDI1	414301	broad.mit.edu	37	11	103907704	103907704	+	Silent	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:103907704C>A	uc001phr.2	+	c.154C>A	c.(154-156)CGA>AGA	p.R52R	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	52	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)										0.712644	204.584911	208.147055	62	25	KEEP	---	---	---	---	capture		Silent	SNP	103907704	103907704	4499	11	C	A	A	A	347	27	DDI1	1	1
ATM	472	broad.mit.edu	37	11	108153446	108153446	+	Nonsense_Mutation	SNP	A	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:108153446A>T	uc001pkb.1	+	c.3586A>T	c.(3586-3588)AAA>TAA	p.K1196*	ATM_uc009yxr.1_Nonsense_Mutation_p.K1196*	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1196					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(24)|breast(14)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	238		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)						1073	TSP Lung(14;0.12)			0.723077	146.139413	149.050716	47	18	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	108153446	108153446	1128	11	A	T	T	T	117	9	ATM	5	3
TMEM225	338661	broad.mit.edu	37	11	123756006	123756006	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:123756006C>T	uc001pzi.2	-	c.127G>A	c.(127-129)GCC>ACC	p.A43T		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	43						integral to membrane				pancreas(1)	1														0.352113	74.053356	75.423068	25	46	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	123756006	123756006	16683	11	C	T	T	T	364	28	TMEM225	2	2
AMBRA1	55626	broad.mit.edu	37	11	46419198	46419198	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:46419198C>A	uc001ncv.2	-	c.3708G>T	c.(3706-3708)TGG>TGT	p.W1236C	AMBRA1_uc010rgt.1_3'UTR|AMBRA1_uc009ylc.1_Missense_Mutation_p.W1204C|AMBRA1_uc001ncu.1_Missense_Mutation_p.W1143C|AMBRA1_uc010rgu.1_Missense_Mutation_p.W1233C|AMBRA1_uc001ncw.2_Missense_Mutation_p.W1114C|AMBRA1_uc001ncx.2_Missense_Mutation_p.W1173C	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1233					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)										0.772727	53.039184	54.552702	17	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	46419198	46419198	568	11	C	A	A	A	286	22	AMBRA1	2	2
OR4X2	119764	broad.mit.edu	37	11	48267190	48267190	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:48267190C>A	uc001ngs.1	+	c.535C>A	c.(535-537)CTT>ATT	p.L179I		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0														0.54717	278.046184	278.357411	87	72	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	48267190	48267190	11495	11	C	A	A	A	260	20	OR4X2	2	2
OR8J3	81168	broad.mit.edu	37	11	55904448	55904448	+	Silent	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:55904448C>A	uc010riz.1	-	c.747G>T	c.(745-747)ACG>ACT	p.T249T		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00693)													0.58	93.068336	93.34766	29	21	KEEP	---	---	---	---	capture		Silent	SNP	55904448	55904448	11653	11	C	A	A	A	288	23	OR8J3	1	1
OR56A3	390083	broad.mit.edu	37	11	5968696	5968696	+	Silent	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:5968696C>A	uc010qzt.1	+	c.120C>A	c.(118-120)CTC>CTA	p.L40L		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)										0.775	192.941335	198.479948	62	18	KEEP	---	---	---	---	capture		Silent	SNP	5968696	5968696	11544	11	C	A	A	A	405	32	OR56A3	2	2
C11orf9	745	broad.mit.edu	37	11	61533653	61533653	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:61533653C>A	uc001nsc.1	+	c.358C>A	c.(358-360)CCC>ACC	p.P120T	C11orf9_uc001nse.1_Missense_Mutation_p.P111T	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	120	Pro-rich.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1														0.333333	24.999241	25.708774	10	20	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	61533653	61533653	1711	11	C	A	A	A	338	26	C11orf9	2	2
TRIM3	10612	broad.mit.edu	37	11	6477727	6477727	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:6477727C>A	uc001mdh.2	-	c.1229G>T	c.(1228-1230)CGC>CTC	p.R410L	TRIM3_uc001mdi.2_Missense_Mutation_p.R410L|TRIM3_uc010raj.1_Missense_Mutation_p.R291L|TRIM3_uc009yfd.2_Missense_Mutation_p.R410L|TRIM3_uc010rak.1_Missense_Mutation_p.R410L|TRIM3_uc001mdj.2_Missense_Mutation_p.R291L	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	410	Filamin.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		Melanoma(6;5 510 1540 25169 29084)								0.736842	45.456616	46.425946	14	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	6477727	6477727	17048	11	C	A	A	A	351	27	TRIM3	1	1
TRIM3	10612	broad.mit.edu	37	11	6478565	6478565	+	Silent	SNP	C	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:6478565C>G	uc001mdh.2	-	c.657G>C	c.(655-657)CTG>CTC	p.L219L	TRIM3_uc001mdi.2_Silent_p.L219L|TRIM3_uc010raj.1_Silent_p.L100L|TRIM3_uc009yfd.2_Silent_p.L219L|TRIM3_uc010rak.1_Silent_p.L219L|TRIM3_uc001mdj.2_Silent_p.L100L	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	219	Potential.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		Melanoma(6;5 510 1540 25169 29084)								0.684211	170.80962	173.098566	52	24	KEEP	---	---	---	---	capture		Silent	SNP	6478565	6478565	17048	11	C	G	G	G	262	21	TRIM3	3	3
C11orf30	56946	broad.mit.edu	37	11	76162966	76162966	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:76162966G>T	uc010rsb.1	+	c.135G>T	c.(133-135)AAG>AAT	p.K45N	C11orf30_uc001oxj.2_Missense_Mutation_p.K45N|C11orf30_uc001oxk.2_Missense_Mutation_p.K45N|C11orf30_uc009yuj.1_Missense_Mutation_p.K45N|C11orf30_uc010rsa.1_Missense_Mutation_p.K45N|C11orf30_uc001oxl.2_Missense_Mutation_p.K45N|C11orf30_uc001oxm.2_Missense_Mutation_p.K45N|C11orf30_uc010rsc.1_Missense_Mutation_p.K45N|C11orf30_uc001oxn.2_Missense_Mutation_p.K45N|C11orf30_uc010rsd.1_Missense_Mutation_p.K45N	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	45	Interaction with BRCA2.|ENT.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6														0.586207	47.027293	47.207572	17	12	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	76162966	76162966	1674	11	G	T	T	T	425	33	C11orf30	2	2
LRRC32	2615	broad.mit.edu	37	11	76372262	76372262	+	Silent	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:76372262G>A	uc001oxq.3	-	c.375C>T	c.(373-375)CGC>CGT	p.R125R	LRRC32_uc001oxr.3_Silent_p.R125R|LRRC32_uc010rsf.1_Silent_p.R125R	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	125	Extracellular (Potential).|LRR 4.					integral to plasma membrane					0														0.484848	94.50359	94.516201	32	34	KEEP	---	---	---	---	capture		Silent	SNP	76372262	76372262	9362	11	G	A	A	A	483	38	LRRC32	1	1
DLG2	1740	broad.mit.edu	37	11	83170879	83170879	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:83170879G>T	uc001pak.2	-	c.2910C>A	c.(2908-2910)CCC>CCA	p.P970P	DLG2_uc001pai.2_Silent_p.P744P|DLG2_uc010rsy.1_Silent_p.P814P|DLG2_uc001paj.2_Silent_p.P865P|DLG2_uc010rsz.1_Silent_p.P861P|DLG2_uc010rta.1_Silent_p.P847P|DLG2_uc010rsw.1_Silent_p.P329P|DLG2_uc010rsx.1_Silent_p.P342P	NM_001142699	NP_001136171	Q15700	DLG2_HUMAN	chapsyn-110 isoform 1	865						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)	5		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)												0.292308	46.774911	49.303251	19	46	KEEP	---	---	---	---	capture		Silent	SNP	83170879	83170879	4735	11	G	T	T	T	444	35	DLG2	2	2
DLG2	1740	broad.mit.edu	37	11	83177805	83177805	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:83177805G>T	uc001pak.2	-	c.2675C>A	c.(2674-2676)GCC>GAC	p.A892D	DLG2_uc001pai.2_Missense_Mutation_p.A666D|DLG2_uc010rsy.1_Missense_Mutation_p.A736D|DLG2_uc001paj.2_Missense_Mutation_p.A787D|DLG2_uc010rsz.1_Missense_Mutation_p.A783D|DLG2_uc010rta.1_Missense_Mutation_p.A769D|DLG2_uc010rtb.1_Missense_Mutation_p.A754D|DLG2_uc010rsw.1_Missense_Mutation_p.A251D|DLG2_uc010rsx.1_Missense_Mutation_p.A264D	NM_001142699	NP_001136171	Q15700	DLG2_HUMAN	chapsyn-110 isoform 1	787	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)	5		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)												0.228916	39.6994	45.317812	19	64	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	83177805	83177805	4735	11	G	T	T	T	546	42	DLG2	2	2
TRIM49	57093	broad.mit.edu	37	11	89531774	89531774	+	Nonsense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:89531774C>A	uc001pdb.2	-	c.883G>T	c.(883-885)GAA>TAA	p.E295*		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	295	B30.2/SPRY.					intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)												0.296296	21.407541	22.39916	8	19	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	89531774	89531774	17069	11	C	A	A	A	416	32	TRIM49	5	2
FAT3	120114	broad.mit.edu	37	11	92534753	92534753	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:92534753G>T	uc001pdj.3	+	c.8574G>T	c.(8572-8574)CAG>CAT	p.Q2858H		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2858	Cadherin 26.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)									TCGA Ovarian(4;0.039)			0.666667	12.401018	12.548343	4	2	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	92534753	92534753	5927	11	G	T	T	T	438	34	FAT3	2	2
RASAL1	8437	broad.mit.edu	37	12	113554954	113554954	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:113554954G>T	uc001tun.1	-	c.655C>A	c.(655-657)CCA>ACA	p.P219T	RASAL1_uc010syp.1_Missense_Mutation_p.P219T|RASAL1_uc001tul.2_Missense_Mutation_p.P219T|RASAL1_uc001tum.1_Missense_Mutation_p.P219T|RASAL1_uc010syq.1_Missense_Mutation_p.P219T|RASAL1_uc001tuo.3_Missense_Mutation_p.P219T|RASAL1_uc010syr.1_Missense_Mutation_p.P219T	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	219					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(1)	3														0.609756	75.080247	75.512685	25	16	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	113554954	113554954	13524	12	G	T	T	T	533	41	RASAL1	2	2
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:25398285C>A	uc001rgp.1	-	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_Non-coding_Transcript	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(2374)|p.G12S(1078)|p.G12R(674)|p.G12?(50)|p.G12F(33)|p.G12D(15)|p.G12N(6)|p.G12V(6)|p.G12L(5)|p.G12I(3)|p.G12W(3)|p.G12A(2)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12_G13insG(1)		large_intestine(11742)|pancreas(3256)|lung(2694)|biliary_tract(514)|ovary(437)|endometrium(339)|haematopoietic_and_lymphoid_tissue(303)|stomach(179)|thyroid(145)|prostate(85)|soft_tissue(75)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|breast(27)|liver(21)|testis(17)|oesophagus(15)|central_nervous_system(8)|peritoneum(5)|kidney(5)|salivary_gland(5)|thymus(5)|eye(4)|gastrointestinal_tract_(site_indeterminate)(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	20148	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	p.G12R(PSN1-Tumor)|p.G12C(NCIH1373-Tumor)|p.G12C(NCIH1792-Tumor)|p.G12S(KMS20-Tumor)|p.G12C(HCC44-Tumor)|p.G12C(HCC1171-Tumor)|p.G12C(SW837-Tumor)|p.G12C(LU65-Tumor)|p.G12R(HUPT3-Tumor)|p.G12S(A549-Tumor)|p.G12C(NCIH2122-Tumor)|p.G12R(KP2-Tumor)|p.G12C(OV56-Tumor)|p.G12C(IALM-Tumor)|p.G12C(SW1463-Tumor)|p.G12C(SW1573-Tumor)|p.G12R(NCIH1339-Tumor)|p.G12C(NCIH23-Tumor)|p.G12C(MIAPACA2-Tumor)|p.G12C(CALU1-Tumor)|p.G12C(NCIH2030-Tumor)|p.G12S(LS123-Tumor)|p.G12C(KYSE410-Tumor)|p.G12C(UMUC3-Tumor)|p.G12C(NCIH2291-Tumor)|p.G12R(TCCPAN2-Tumor)|p.G12C(KHM1B-Tumor)|p.G12C(LU99-Tumor)|p.G12C(NCIH358-Tumor)|p.G12C(NCIH1385-Tumor)|p.G12R(CAL62-Tumor)	262	TSP Lung(1;<1E-8)|Multiple Myeloma(2;<1E-6)			0.6	50.229445	50.447906	15	10	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	25398285	25398285	8753	12	C	A	A	A	273	21	KRAS	2	2
MLL2	8085	broad.mit.edu	37	12	49419995	49419995	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:49419995C>A	uc001rta.3	-	c.15754G>T	c.(15754-15756)GAC>TAC	p.D5252Y		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5252	FY-rich C-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of gene-specific transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|promoter binding|protein binding|zinc ion binding			kidney(16)|lung(4)|skin(4)|ovary(3)|pancreas(2)	29														0.147059	10.29092	18.485804	10	58	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	49419995	49419995	10011	12	C	A	A	A	390	30	MLL2	2	2
DPY19L2	283417	broad.mit.edu	37	12	64061909	64061909	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:64061909G>T	uc001srp.1	-	c.265C>A	c.(265-267)CTG>ATG	p.L89M	DPY19L2_uc009zqk.1_Non-coding_Transcript	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	89					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)	1			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)										0.587302	228.954755	229.79563	74	52	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	64061909	64061909	4925	12	G	T	T	T	451	35	DPY19L2	2	2
NANOG	79923	broad.mit.edu	37	12	7942298	7942298	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:7942298G>A	uc009zfy.1	+	c.88G>A	c.(88-90)GGG>AGG	p.G30R		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	30					cell proliferation|embryo development|regulation of transcription, DNA-dependent|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulator activity				0				Kidney(36;0.0872)										0.355372	124.682955	126.916268	43	78	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	7942298	7942298	10546	12	G	A	A	A	611	47	NANOG	2	2
PZP	5858	broad.mit.edu	37	12	9305844	9305844	+	Silent	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:9305844C>T	uc001qvl.2	-	c.3870G>A	c.(3868-3870)CAG>CAA	p.Q1290Q	PZP_uc009zgl.2_Silent_p.Q1076Q	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|large_intestine(1)	4						Melanoma(125;1402 1695 4685 34487 38571)								0.26087	75.315126	81.258833	30	85	KEEP	---	---	---	---	capture		Silent	SNP	9305844	9305844	13327	12	C	T	T	T	415	32	PZP	2	2
NTN4	59277	broad.mit.edu	37	12	96107067	96107067	+	Missense_Mutation	SNP	T	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:96107067T>C	uc001tei.2	-	c.914A>G	c.(913-915)CAG>CGG	p.Q305R	NTN4_uc009ztf.2_Missense_Mutation_p.Q305R|NTN4_uc009ztg.2_Missense_Mutation_p.Q268R	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	305	Laminin EGF-like 1.				axon guidance	basement membrane|plasma membrane				ovary(1)	1														0.22449	21.382663	24.820535	11	38	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	96107067	96107067	11107	12	T	C	C	C	715	55	NTN4	4	4
FAM70B	348013	broad.mit.edu	37	13	114507949	114507949	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:114507949G>T	uc001vuh.2	+	c.761G>T	c.(760-762)CGC>CTC	p.R254L		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	254						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)											0.837209	119.266233	123.898212	36	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	114507949	114507949	5829	13	G	T	T	T	494	38	FAM70B	1	1
MYH7	4625	broad.mit.edu	37	14	23894904	23894904	+	Missense_Mutation	SNP	C	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:23894904C>G	uc001wjx.2	-	c.2286G>C	c.(2284-2286)AAG>AAC	p.K762N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	762	Actin-binding.|Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)	3	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)										0.361702	92.241074	93.815742	34	60	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	23894904	23894904	10434	14	C	G	G	G	311	24	MYH7	3	3
SEC23A	10484	broad.mit.edu	37	14	39560913	39560913	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:39560913C>A	uc001wup.1	-	c.371G>T	c.(370-372)GGT>GTT	p.G124V	SEC23A_uc010tqa.1_5'UTR|SEC23A_uc010tqb.1_Missense_Mutation_p.G95V|SEC23A_uc010tqc.1_5'UTR	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	124					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)	4	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)										0.507246	108.535587	108.539074	35	34	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	39560913	39560913	14477	14	C	A	A	A	234	18	SEC23A	2	2
SDCCAG1	9147	broad.mit.edu	37	14	50272777	50272777	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:50272777G>T	uc010anj.1	-	c.1819C>A	c.(1819-1821)CGA>AGA	p.R607R	SDCCAG1_uc001wxc.2_Silent_p.R607R|SDCCAG1_uc010tqi.1_Silent_p.R586R|SDCCAG1_uc001wxe.2_Silent_p.R565R|SDCCAG1_uc001wxd.1_Silent_p.R12R	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	607						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)										0.545455	82.323701	82.406842	24	20	KEEP	---	---	---	---	capture		Silent	SNP	50272777	50272777	14442	14	G	T	T	T	519	40	SDCCAG1	1	1
ACOT2	10965	broad.mit.edu	37	14	74036534	74036534	+	Missense_Mutation	SNP	G	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:74036534G>C	uc001xon.3	+	c.590G>C	c.(589-591)CGG>CCG	p.R197P	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Intron	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	197					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)										0.65	38.739015	39.131232	13	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	74036534	74036534	153	14	G	C	C	C	507	39	ACOT2	3	3
PCSK6	5046	broad.mit.edu	37	15	101865129	101865129	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:101865129C>T	uc002bxa.2	-	c.2303G>A	c.(2302-2304)CGC>CAC	p.R768H	PCSK6_uc010bpd.2_Missense_Mutation_p.R564H|PCSK6_uc002bwy.2_Missense_Mutation_p.R768H|PCSK6_uc010bpe.2_Missense_Mutation_p.R755H|PCSK6_uc002bxb.2_Missense_Mutation_p.R755H	NM_138320	NP_612193	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	768	CRM (Cys-rich motif).				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)											0.189189	14.615073	17.95034	7	30	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	101865129	101865129	12025	15	C	T	T	T	351	27	PCSK6	1	1
OR4M2	390538	broad.mit.edu	37	15	22369186	22369186	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:22369186G>T	uc010tzu.1	+	c.611G>T	c.(610-612)GGT>GTT	p.G204V	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)										0.719626	259.517223	264.163701	77	30	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	22369186	22369186	11486	15	G	T	T	T	572	44	OR4M2	2	2
TMOD3	29766	broad.mit.edu	37	15	52188673	52188673	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:52188673G>A	uc002abm.2	+	c.685G>A	c.(685-687)GTG>ATG	p.V229M	TMOD3_uc010bfc.1_Non-coding_Transcript	NM_014547	NP_055362	Q9NYL9	TMOD3_HUMAN	tropomodulin 3 (ubiquitous)	229						cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1				all cancers(107;0.00194)		Colon(122;1837 2251 18387 22826)								0.413793	65.65762	66.04088	24	34	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	52188673	52188673	16775	15	G	A	A	A	624	48	TMOD3	2	2
ABCA3	21	broad.mit.edu	37	16	2338079	2338079	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:2338079C>A	uc002cpy.1	-	c.2952G>T	c.(2950-2952)GAG>GAT	p.E984D	ABCA3_uc010bsk.1_Missense_Mutation_p.E926D	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	984					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|breast(3)|central_nervous_system(3)	10		Ovarian(90;0.17)								701				0.416667	14.772526	14.845372	5	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	2338079	2338079	34	16	C	A	A	A	363	28	ABCA3	2	2
OR2C1	4993	broad.mit.edu	37	16	3406340	3406340	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:3406340G>A	uc002cuw.1	+	c.400G>A	c.(400-402)GCC>ACC	p.A134T		NM_012368	NP_036500	O95371	OR2C1_HUMAN	olfactory receptor, family 2, subfamily C,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1														0.341463	39.067537	39.963839	14	27	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	3406340	3406340	11398	16	G	A	A	A	494	38	OR2C1	1	1
C16orf71	146562	broad.mit.edu	37	16	4790576	4790576	+	Silent	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:4790576G>A	uc002cxn.2	+	c.699G>A	c.(697-699)GCG>GCA	p.A233A		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	233										central_nervous_system(1)	1														0.384615	26.548268	26.849705	10	16	KEEP	---	---	---	---	capture		Silent	SNP	4790576	4790576	1883	16	G	A	A	A	483	38	C16orf71	1	1
ABCC11	85320	broad.mit.edu	37	16	48256677	48256677	+	Silent	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:48256677C>A	uc002eff.1	-	c.609G>T	c.(607-609)GTG>GTT	p.V203V	ABCC11_uc002efg.1_Silent_p.V203V|ABCC11_uc002efh.1_Silent_p.V203V|ABCC11_uc010vgl.1_Silent_p.V203V	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	203	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|central_nervous_system(1)	4		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)												0.28125	24.962637	26.338002	9	23	KEEP	---	---	---	---	capture		Silent	SNP	48256677	48256677	52	16	C	A	A	A	262	21	ABCC11	2	2
PLEKHG4	25894	broad.mit.edu	37	16	67322099	67322099	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:67322099G>T	uc002eso.3	+	c.3250G>T	c.(3250-3252)GCC>TCC	p.A1084S	PLEKHG4_uc002esp.3_Missense_Mutation_p.A891S|PLEKHG4_uc002esq.3_Missense_Mutation_p.A1084S|PLEKHG4_uc010cef.2_Missense_Mutation_p.A1084S|PLEKHG4_uc002ess.3_Missense_Mutation_p.A1084S|PLEKHG4_uc010ceg.2_Missense_Mutation_p.A1003S	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	1084					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)										0.227848	41.522835	46.882773	18	61	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	67322099	67322099	12497	16	G	T	T	T	442	34	PLEKHG4	2	2
IRF8	3394	broad.mit.edu	37	16	85946755	85946755	+	Missense_Mutation	SNP	A	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:85946755A>G	uc002fjh.2	+	c.466A>G	c.(466-468)ATG>GTG	p.M156V	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	156					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)												0.347826	85.166683	87.049397	32	60	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	85946755	85946755	8139	16	A	G	G	G	104	8	IRF8	4	4
MYH13	8735	broad.mit.edu	37	17	10212976	10212976	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:10212976G>A	uc002gmk.1	-	c.4828C>T	c.(4828-4830)CGC>TGC	p.R1610C		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1610	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)	4														0.352941	18.660859	18.977878	6	11	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10212976	10212976	10427	17	G	A	A	A	507	39	MYH13	1	1
MYH2	4620	broad.mit.edu	37	17	10426814	10426814	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:10426814C>T	uc010coi.2	-	c.5471G>A	c.(5470-5472)AGG>AAG	p.R1824K	MYH2_uc002gmp.3_Missense_Mutation_p.R1824K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1824	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|lung(1)|kidney(1)	11														0.34375	66.228534	67.609639	22	42	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10426814	10426814	10430	17	C	T	T	T	312	24	MYH2	2	2
GAS2L2	246176	broad.mit.edu	37	17	34072791	34072791	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:34072791G>T	uc002hjv.1	-	c.1725C>A	c.(1723-1725)TCC>TCA	p.S575S		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	575					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)										0.217822	50.60068	58.015516	22	79	KEEP	---	---	---	---	capture		Silent	SNP	34072791	34072791	6511	17	G	T	T	T	444	35	GAS2L2	2	2
MLLT6	4302	broad.mit.edu	37	17	36873066	36873066	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:36873066G>T	uc002hqi.3	+	c.1483G>T	c.(1483-1485)GCC>TCC	p.A495S	MLLT6_uc002hqj.2_Intron|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	495					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			skin(1)	1	Breast(7;4.43e-21)									439				0.166667	7.85978	11.019108	5	25	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	36873066	36873066	10020	17	G	T	T	T	598	46	MLLT6	2	2
KRT12	3859	broad.mit.edu	37	17	39021155	39021155	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:39021155C>T	uc002hvk.2	-	c.710G>A	c.(709-711)CGG>CAG	p.R237Q		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	237	Rod.|Coil 1B.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)												0.24	89.818447	99.089859	36	114	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	39021155	39021155	8764	17	C	T	T	T	299	23	KRT12	1	1
BECN1	8678	broad.mit.edu	37	17	40962818	40962818	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:40962818C>A	uc002ibo.3	-	c.1313G>T	c.(1312-1314)TGG>TTG	p.W438L	CNTD1_uc002ibm.3_3'UTR|CNTD1_uc010wha.1_3'UTR|BECN1_uc010whb.1_Missense_Mutation_p.W351L|BECN1_uc010whc.1_3'UTR|BECN1_uc002ibn.2_Missense_Mutation_p.W438L	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	438					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)										0.215686	50.581516	58.128967	22	80	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	40962818	40962818	1419	17	C	A	A	A	273	21	BECN1	2	2
SPNS3	201305	broad.mit.edu	37	17	4337281	4337281	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:4337281G>T	uc002fxt.2	+	c.19G>T	c.(19-21)GCG>TCG	p.A7S	SPNS3_uc002fxu.2_5'UTR	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	7					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1														0.428571	14.4234	14.48985	6	8	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	4337281	4337281	15589	17	G	T	T	T	442	34	SPNS3	2	2
WNT9B	7484	broad.mit.edu	37	17	44950100	44950100	+	Missense_Mutation	SNP	A	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:44950100A>T	uc002ikw.1	+	c.295A>T	c.(295-297)AAC>TAC	p.N99Y	WNT9B_uc002ikx.1_Missense_Mutation_p.N99Y	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	99					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|negative regulation of gene-specific transcription from RNA polymerase II promoter|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding				0			BRCA - Breast invasive adenocarcinoma(9;0.0257)											0.142857	5.1834	8.624556	4	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	44950100	44950100	17973	17	A	T	T	T	117	9	WNT9B	3	3
ABI3	51225	broad.mit.edu	37	17	47299555	47299555	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:47299555C>A	uc002iop.1	+	c.905C>A	c.(904-906)CCC>CAC	p.P302H	ABI3_uc002ioq.1_Missense_Mutation_p.P296H	NM_016428	NP_057512	Q9P2A4	ABI3_HUMAN	NESH protein isoform 1	302	Pro-rich.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)											0.679612	215.359205	218.307735	70	33	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	47299555	47299555	91	17	C	A	A	A	286	22	ABI3	2	2
DNAH17	8632	broad.mit.edu	37	17	76503840	76503840	+	Silent	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:76503840G>A	uc010wtu.1	-	c.159C>T	c.(157-159)CAC>CAT	p.H53H		CR620279				full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)											0.285714	10.894152	11.471058	4	10	KEEP	---	---	---	---	capture		Silent	SNP	76503840	76503840	4784	17	G	A	A	A	516	40	DNAH17	1	1
PIK3R5	23533	broad.mit.edu	37	17	8791618	8791618	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:8791618C>T	uc002glt.2	-	c.1486G>A	c.(1486-1488)GCT>ACT	p.A496T	PIK3R5_uc010vuz.1_Missense_Mutation_p.A496T|PIK3R5_uc002glu.3_Missense_Mutation_p.A110T|PIK3R5_uc010coa.1_3'UTR|PIK3R5_uc010cob.1_Missense_Mutation_p.A110T	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	496					platelet activation	cytosol|membrane|nucleus				large_intestine(1)|central_nervous_system(1)	2						NSCLC(18;589 615 7696 20311 50332)								0.363636	38.965645	39.69398	16	28	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	8791618	8791618	12346	17	C	T	T	T	325	25	PIK3R5	2	2
ZNF521	25925	broad.mit.edu	37	18	22804516	22804516	+	Silent	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:22804516C>T	uc002kvk.2	-	c.3366G>A	c.(3364-3366)GAG>GAA	p.E1122E	ZNF521_uc010xbe.1_Non-coding_Transcript|ZNF521_uc010dly.2_Silent_p.E1122E|ZNF521_uc002kvl.2_Silent_p.E902E	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1122					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)									266				0.578947	70.9183	71.119729	22	16	KEEP	---	---	---	---	capture		Silent	SNP	22804516	22804516	18559	18	C	T	T	T	415	32	ZNF521	2	2
SPPL2B	56928	broad.mit.edu	37	19	2337525	2337525	+	Silent	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:2337525C>A	uc002lvs.2	+	c.270C>A	c.(268-270)ATC>ATA	p.I90I	SPPL2B_uc010dsw.1_Silent_p.I62I|SPPL2B_uc010dsy.1_Silent_p.I62I|SPPL2B_uc010dsz.1_Silent_p.I90I|SPPL2B_uc002lvr.2_Silent_p.I90I|SPPL2B_uc010dta.1_5'Flank|SPPL2B_uc002lvu.2_5'Flank	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2	90	Cytoplasmic (Potential).|PA.					Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)										0.808511	116.860185	121.032526	38	9	KEEP	---	---	---	---	capture		Silent	SNP	2337525	2337525	15602	19	C	A	A	A	382	30	SPPL2B	2	2
CCNE1	898	broad.mit.edu	37	19	30314605	30314606	+	Missense_Mutation	DNP	GG	CT	CT			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:30314605_30314606GG>CT	uc002nsn.2	+	c.1154_1155GG>CT	c.(1153-1155)AGG>ACT	p.R385T	CCNE1_uc002nso.2_Missense_Mutation_p.R370T|CCNE1_uc002nsp.2_Missense_Mutation_p.R132T	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	385					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|transcription coactivator activity			lung(1)	1	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)							193				0.303571	50.982897	52.894816	17	39	KEEP	---	---	---	---	capture		Missense_Mutation	DNP	30314605	30314606	3047	19	GG	CT	CT	CT	455	35	CCNE1	3	3
TSHZ3	57616	broad.mit.edu	37	19	31770491	31770491	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:31770491G>T	uc002nsy.3	-	c.208C>A	c.(208-210)CAT>AAT	p.H70N		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	70					regulation of respiratory gaseous exchange by neurological system process|regulation of transcription, DNA-dependent	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription repressor activity|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|skin(1)	7	Esophageal squamous(110;0.226)													0.32	22.415252	23.122266	8	17	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	31770491	31770491	17176	19	G	T	T	T	611	47	TSHZ3	2	2
KIR3DL1	3811	broad.mit.edu	37	19	55331209	55331209	+	Silent	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:55331209C>T	uc002qhk.3	+	c.397C>T	c.(397-399)CTG>TTG	p.L133L	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Silent_p.L75L|KIR3DL1_uc010esf.2_Silent_p.L38L|KIR3DL1_uc010yfo.1_Silent_p.L75L|KIR3DL1_uc002qhl.3_Silent_p.L133L	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	133	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|kidney(1)	3				GBM - Glioblastoma multiforme(193;0.0192)										0.57971	137.1144	137.498676	40	29	KEEP	---	---	---	---	capture		Silent	SNP	55331209	55331209	8632	19	C	T	T	T	311	24	KIR3DL1	2	2
NLRP8	126205	broad.mit.edu	37	19	56466759	56466759	+	Silent	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:56466759G>A	uc002qmh.2	+	c.1335G>A	c.(1333-1335)AAG>AAA	p.K445K	NLRP8_uc010etg.2_Silent_p.K445K	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	445	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|large_intestine(1)|kidney(1)|skin(1)	10		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)										0.431034	81.367161	81.607583	25	33	KEEP	---	---	---	---	capture		Silent	SNP	56466759	56466759	10886	19	G	A	A	A	425	33	NLRP8	2	2
ACER1	125981	broad.mit.edu	37	19	6306758	6306758	+	Nonsense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:6306758G>T	uc002mel.2	-	c.762C>A	c.(760-762)TAC>TAA	p.Y254*		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	254	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0														0.8125	45.984566	47.447978	13	3	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	6306758	6306758	139	19	G	T	T	T	516	40	ACER1	5	1
CELF3	11189	broad.mit.edu	37	1	151677546	151677546	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:151677546G>T	uc001eys.1	-	c.1369C>A	c.(1369-1371)CGG>AGG	p.R457R	CELF3_uc010pdh.1_Silent_p.R243R|CELF3_uc001eyr.2_Silent_p.R456R|CELF3_uc009wmy.2_Silent_p.R407R|CELF3_uc009wmx.1_Silent_p.R456R	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	457	RRM 3.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2														0.409836	71.457376	71.88873	25	36	KEEP	---	---	---	---	capture		Silent	SNP	151677546	151677546	3350	1	G	T	T	T	493	38	CELF3	1	1
RXFP4	339403	broad.mit.edu	37	1	155912009	155912009	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:155912009C>A	uc010pgs.1	+	c.509C>A	c.(508-510)GCC>GAC	p.A170D		NM_181885	NP_871001	Q8TDU9	RL3R2_HUMAN	relaxin 3 receptor 2	170	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	angiotensin type II receptor activity				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)													0.22449	50.399245	57.235322	22	76	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	155912009	155912009	14242	1	C	A	A	A	338	26	RXFP4	2	2
SPTA1	6708	broad.mit.edu	37	1	158605807	158605807	+	Silent	SNP	T	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:158605807T>A	uc001fst.1	-	c.5328A>T	c.(5326-5328)GCA>GCT	p.A1776A		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1776	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|breast(1)	5	all_hematologic(112;0.0378)													0.411215	272.452147	273.925251	88	126	KEEP	---	---	---	---	capture		Silent	SNP	158605807	158605807	15630	1	T	A	A	A	704	55	SPTA1	3	3
OR6N2	81442	broad.mit.edu	37	1	158747003	158747003	+	Missense_Mutation	SNP	A	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:158747003A>C	uc010pir.1	-	c.423T>G	c.(421-423)TGT>TGG	p.C141W		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)													0.213333	43.96612	49.653822	16	59	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	158747003	158747003	11617	1	A	C	C	C	76	6	OR6N2	4	4
HMCN1	83872	broad.mit.edu	37	1	185985107	185985107	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:185985107G>T	uc001grq.1	+	c.4927G>T	c.(4927-4929)GGC>TGC	p.G1643C		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1643	Ig-like C2-type 14.				bioluminescence|protein-chromophore linkage|response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)	22														0.431818	112.013903	112.374091	38	50	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	185985107	185985107	7511	1	G	T	T	T	455	35	HMCN1	2	2
TMEM81	388730	broad.mit.edu	37	1	205052919	205052919	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:205052919C>A	uc001hbt.2	-	c.530G>T	c.(529-531)GGG>GTG	p.G177V		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	transmembrane protein 81 precursor	177	Extracellular (Potential).					integral to membrane					0	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)											0.393939	74.826718	75.478881	26	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	205052919	205052919	16744	1	C	A	A	A	286	22	TMEM81	2	2
KCNH1	3756	broad.mit.edu	37	1	211276891	211276891	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:211276891G>A	uc001hib.2	-	c.257C>T	c.(256-258)ACA>ATA	p.T86I	KCNH1_uc001hic.2_Missense_Mutation_p.T86I	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	86	Cytoplasmic (Potential).|PAS.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)										0.208333	32.32823	37.969921	15	57	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	211276891	211276891	8336	1	G	A	A	A	624	48	KCNH1	2	2
C1orf65	164127	broad.mit.edu	37	1	223567018	223567018	+	Silent	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:223567018C>A	uc001hoa.2	+	c.201C>A	c.(199-201)ACC>ACA	p.T67T		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	67										central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0704)										0.454545	25.040558	25.080768	10	12	KEEP	---	---	---	---	capture		Silent	SNP	223567018	223567018	2129	1	C	A	A	A	275	22	C1orf65	2	2
OBSCN	84033	broad.mit.edu	37	1	228554800	228554800	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:228554800G>T	uc009xez.1	+	c.19552G>T	c.(19552-19554)GCG>TCG	p.A6518S	OBSCN_uc001hsr.1_Missense_Mutation_p.A1147S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6518	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			large_intestine(7)|breast(5)|ovary(4)|skin(2)|stomach(1)|central_nervous_system(1)|pancreas(1)	21		Prostate(94;0.0405)								4006				0.454545	15.67874	15.697713	5	6	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	228554800	228554800	11217	1	G	T	T	T	494	38	OBSCN	1	1
MTR	4548	broad.mit.edu	37	1	237057847	237057847	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:237057847G>T	uc001hyi.3	+	c.3395G>T	c.(3394-3396)CGG>CTG	p.R1132L	MTR_uc010pxw.1_Missense_Mutation_p.R725L|MTR_uc010pxx.1_Missense_Mutation_p.R1081L|MTR_uc010pxy.1_Missense_Mutation_p.R986L	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	1132	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)									0.317073	37.86364	39.081728	13	28	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	237057847	237057847	10351	1	G	T	T	T	507	39	MTR	1	1
MYOM3	127294	broad.mit.edu	37	1	24419571	24419571	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:24419571C>A	uc001bin.3	-	c.956G>T	c.(955-957)CGG>CTG	p.R319L	MYOM3_uc001bim.3_5'UTR|MYOM3_uc001bio.2_Missense_Mutation_p.R319L|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	319	Ig-like C2-type 2.									ovary(1)	1		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)										0.857143	61.355512	63.934451	18	3	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	24419571	24419571	10488	1	C	A	A	A	299	23	MYOM3	1	1
ZMYM1	79830	broad.mit.edu	37	1	35570213	35570213	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:35570213G>T	uc001bym.2	+	c.650G>T	c.(649-651)TGC>TTC	p.C217F	ZMYM1_uc009vus.1_Non-coding_Transcript|ZMYM1_uc001byn.2_Missense_Mutation_p.C217F|ZMYM1_uc010ohu.1_Missense_Mutation_p.C217F|ZMYM1_uc001byo.2_5'UTR|ZMYM1_uc009vut.2_Missense_Mutation_p.C142F	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	217	MYM-type 3.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)												0.74359	96.278434	98.371166	29	10	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	35570213	35570213	18290	1	G	T	T	T	598	46	ZMYM1	2	2
SIRPB1	10326	broad.mit.edu	37	20	1559087	1559087	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:1559087G>T	uc010gai.2	-	c.330C>A	c.(328-330)ATC>ATA	p.I110I	SIRPB1_uc002wfk.3_Silent_p.I110I	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	110	Ig-like V-type.|Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1														0.319672	95.740761	99.348163	39	83	KEEP	---	---	---	---	capture		Silent	SNP	1559087	1559087	14828	20	G	T	T	T	577	45	SIRPB1	2	2
MYLK2	85366	broad.mit.edu	37	20	30408221	30408221	+	Silent	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:30408221G>A	uc002wwq.2	+	c.345G>A	c.(343-345)CAG>CAA	p.Q115Q		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	115					cardiac muscle contraction|cardiac muscle tissue morphogenesis|regulation of muscle filament sliding	sarcomere	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)							150				0.410714	69.799837	70.191116	23	33	KEEP	---	---	---	---	capture		Silent	SNP	30408221	30408221	10452	20	G	A	A	A	451	35	MYLK2	2	2
MYBL2	4605	broad.mit.edu	37	20	42331478	42331478	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:42331478G>T	uc002xlb.1	+	c.1300G>T	c.(1300-1302)GAT>TAT	p.D434Y	MYBL2_uc010zwj.1_Missense_Mutation_p.D410Y|MYBL2_uc002xla.1_Missense_Mutation_p.D434Y	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	434					regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)							380				0.333333	58.24758	59.922652	23	46	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	42331478	42331478	10405	20	G	T	T	T	533	41	MYBL2	2	2
SLC12A5	57468	broad.mit.edu	37	20	44685923	44685923	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:44685923C>A	uc010zxl.1	+	c.3309C>A	c.(3307-3309)AAC>AAA	p.N1103K	SLC12A5_uc002xrb.2_Missense_Mutation_p.N1080K	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	1103	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)									0.114504	14.949593	34.141292	15	116	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	44685923	44685923	14881	20	C	A	A	A	233	18	SLC12A5	2	2
ATP9A	10079	broad.mit.edu	37	20	50244178	50244178	+	Silent	SNP	T	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:50244178T>C	uc002xwg.1	-	c.1806A>G	c.(1804-1806)GCA>GCG	p.A602A	ATP9A_uc010gih.1_Silent_p.A466A|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	602	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4														0.20743	156.939556	182.576349	67	256	KEEP	---	---	---	---	capture		Silent	SNP	50244178	50244178	1217	20	T	C	C	C	808	63	ATP9A	4	4
ZNF831	128611	broad.mit.edu	37	20	57769769	57769769	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:57769769C>A	uc002yan.2	+	c.3695C>A	c.(3694-3696)ACC>AAC	p.T1232N		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1232						intracellular	nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(29;0.0085)													0.12766	8.01821	14.370939	6	41	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57769769	57769769	18784	20	C	A	A	A	234	18	ZNF831	2	2
LAMA5	3911	broad.mit.edu	37	20	60913645	60913645	+	Silent	SNP	T	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:60913645T>A	uc002ycq.2	-	c.1497A>T	c.(1495-1497)GCA>GCT	p.A499A		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	499	Laminin EGF-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding|receptor activity|structural molecule activity			pancreas(1)	1	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)									0.625	32.453409	32.672888	10	6	KEEP	---	---	---	---	capture		Silent	SNP	60913645	60913645	8932	20	T	A	A	A	704	55	LAMA5	3	3
ADAMTS5	11096	broad.mit.edu	37	21	28315732	28315732	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:28315732C>A	uc002ymg.2	-	c.1372G>T	c.(1372-1374)GCC>TCC	p.A458S		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	458	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						Esophageal Squamous(53;683 1080 10100 14424 45938)								0.354839	29.403903	29.984141	11	20	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	28315732	28315732	270	21	C	A	A	A	364	28	ADAMTS5	2	2
RIPK4	54101	broad.mit.edu	37	21	43187057	43187057	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr21:43187057C>T	uc002yzn.1	-	c.145G>A	c.(145-147)GCC>ACC	p.A49T		NM_020639	NP_065690	Q9H4D1	Q9H4D1_HUMAN	ankyrin repeat domain 3	49					protein phosphorylation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7										268				0.5625	26.401185	26.462619	9	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43187057	43187057	13860	21	C	T	T	T	338	26	RIPK4	2	2
MYO18B	84700	broad.mit.edu	37	22	26165124	26165124	+	Missense_Mutation	SNP	A	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:26165124A>T	uc003abz.1	+	c.1241A>T	c.(1240-1242)AAG>ATG	p.K414M	MYO18B_uc003aca.1_Missense_Mutation_p.K295M|MYO18B_uc010guy.1_Missense_Mutation_p.K295M|MYO18B_uc010guz.1_Missense_Mutation_p.K295M|MYO18B_uc011aka.1_De_novo_Start_OutOfFrame|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	414						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12										968				0.5	12.699741	12.699741	4	4	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	26165124	26165124	10461	22	A	T	T	T	39	3	MYO18B	3	3
SH3BP1	23616	broad.mit.edu	37	22	38046636	38046636	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:38046636C>T	uc003ati.2	+	c.1502C>T	c.(1501-1503)TCC>TTC	p.S501F	SH3BP1_uc003atg.1_Non-coding_Transcript|SH3BP1_uc011anl.1_3'UTR|SH3BP1_uc003ath.1_Missense_Mutation_p.S501F|SH3BP1_uc003atj.1_Missense_Mutation_p.S437F|SH3BP1_uc003atk.1_Missense_Mutation_p.S415F	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	501					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)													0.319149	38.302474	39.672	15	32	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	38046636	38046636	14735	22	C	T	T	T	390	30	SH3BP1	2	2
EP300	2033	broad.mit.edu	37	22	41568503	41568503	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:41568503G>T	uc003azl.3	+	c.4453G>T	c.(4453-4455)GAT>TAT	p.D1485Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1485					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|histone acetyltransferase activity|transcription coactivator activity|zinc ion binding			central_nervous_system(5)|upper_aerodigestive_tract(3)|pancreas(2)|ovary(1)|lung(1)	12									(T.T-Tumor)	1103				0.217391	10.806942	12.469436	5	18	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	41568503	41568503	5341	22	G	T	T	T	533	41	EP300	2	2
PDIA6	10130	broad.mit.edu	37	2	10927471	10927471	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:10927471G>A	uc002rav.2	-	c.1249C>T	c.(1249-1251)CGC>TGC	p.R417C	PDIA6_uc002rau.2_Missense_Mutation_p.R365C|PDIA6_uc010yjg.1_Missense_Mutation_p.R362C|PDIA6_uc010yjh.1_Missense_Mutation_p.R370C|PDIA6_uc002raw.2_Missense_Mutation_p.R413C	NM_005742	NP_005733	Q15084	PDIA6_HUMAN	protein disulfide isomerase A6 precursor	365					cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		GBM(73;509 1219 34219 41343 41551)								0.378641	106.329403	107.647456	39	64	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	10927471	10927471	12093	2	G	A	A	A	520	40	PDIA6	1	1
YSK4	80122	broad.mit.edu	37	2	135756462	135756462	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:135756462G>T	uc002tue.1	-	c.420C>A	c.(418-420)CCC>CCA	p.P140P	YSK4_uc010fne.1_Silent_p.P112P|YSK4_uc002tuf.1_Silent_p.P140P|YSK4_uc010fnc.1_Silent_p.P140P|YSK4_uc010fnd.1_Intron|YSK4_uc010zbg.1_Silent_p.P140P|YSK4_uc002tui.3_Silent_p.P157P	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	140					protein phosphorylation		ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)						411				0.203704	22.108994	26.506502	11	43	KEEP	---	---	---	---	capture		Silent	SNP	135756462	135756462	18078	2	G	T	T	T	444	35	YSK4	2	2
DDX1	1653	broad.mit.edu	37	2	15742716	15742716	+	Nonsense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:15742716G>T	uc002rce.2	+	c.352G>T	c.(352-354)GAA>TAA	p.E118*	DDX1_uc010yjq.1_Nonsense_Mutation_p.E26*	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	118	B30.2/SPRY.|Necessary for interaction with HNRNPK.|Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	nucleus|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity	p.E118K(1)		central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)						1245				0.33871	54.872956	56.290839	21	41	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	15742716	15742716	4512	2	G	T	T	T	533	41	DDX1	5	2
GALNT5	11227	broad.mit.edu	37	2	158142621	158142621	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:158142621G>T	uc002tzg.2	+	c.1716G>T	c.(1714-1716)AGG>AGT	p.R572S	GALNT5_uc010zci.1_Non-coding_Transcript	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	572	Catalytic subdomain A.|Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)	3														0.183673	18.744572	23.346769	9	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	158142621	158142621	6480	2	G	T	T	T	542	42	GALNT5	2	2
CHRNA1	1134	broad.mit.edu	37	2	175622341	175622341	+	Missense_Mutation	SNP	G	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:175622341G>C	uc002ujd.2	-	c.372C>G	c.(370-372)CAC>CAG	p.H124Q	CHRNA1_uc002uje.2_Missense_Mutation_p.H99Q|CHRNA1_uc002ujf.3_Missense_Mutation_p.H99Q	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	124	Extracellular.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)	3														0.513514	128.702795	128.71331	38	36	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	175622341	175622341	3515	2	G	C	C	C	620	48	CHRNA1	3	3
COL5A2	1290	broad.mit.edu	37	2	189927933	189927933	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:189927933C>A	uc002uqk.2	-	c.1834G>T	c.(1834-1836)GGG>TGG	p.G612W	COL5A2_uc010frx.2_Missense_Mutation_p.G188W	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	612					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)											0.456693	185.034599	185.241221	58	69	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	189927933	189927933	3835	2	C	A	A	A	299	23	COL5A2	1	1
CAPN10	11132	broad.mit.edu	37	2	241536200	241536200	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:241536200G>T	uc002vzk.1	+	c.1584G>T	c.(1582-1584)ACG>ACT	p.T528T	CAPN10_uc002vzl.1_Intron|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Silent_p.T400T|CAPN10_uc002vzo.1_Intron|CAPN10_uc010fzg.1_Intron|CAPN10_uc002vzp.1_Intron|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	528	Domain III 2.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)										0.509434	83.617739	83.621831	27	26	KEEP	---	---	---	---	capture		Silent	SNP	241536200	241536200	2740	2	G	T	T	T	496	39	CAPN10	1	1
KIF1A	547	broad.mit.edu	37	2	241727615	241727615	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:241727615C>A	uc010fzk.2	-	c.216G>T	c.(214-216)CAG>CAT	p.Q72H	KIF1A_uc002vzy.2_Missense_Mutation_p.Q72H|KIF1A_uc002vzz.1_Missense_Mutation_p.Q72H	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	72	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)										0.461538	18.949157	18.965854	6	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	241727615	241727615	8594	2	C	A	A	A	311	24	KIF1A	2	2
DNMT3A	1788	broad.mit.edu	37	2	25468194	25468195	+	Missense_Mutation	DNP	GC	AG	AG			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:25468194_25468195GC>AG	uc002rgc.2	-	c.1481_1482GC>CT	c.(1480-1482)TGC>TCT	p.C494S	DNMT3A_uc002rgd.2_Missense_Mutation_p.C494S|DNMT3A_uc010eyi.2_Non-coding_Transcript|DNMT3A_uc002rgb.2_Missense_Mutation_p.C305S	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	494	Interaction with the PRC2/EED-EZH2 complex (By similarity).|GATA-type; atypical.|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(107)|ovary(3)	110	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)													0.32	24.791481	25.510967	8	17	KEEP	---	---	---	---	capture		Missense_Mutation	DNP	25468194	25468195	4859	2	GC	AG	AG	AG	594	46	DNMT3A	2	2
NRXN1	9378	broad.mit.edu	37	2	50779824	50779824	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:50779824G>T	uc010fbq.2	-	c.1780C>A	c.(1780-1782)CTG>ATG	p.L594M	NRXN1_uc002rxb.3_Missense_Mutation_p.L226M|NRXN1_uc002rxe.3_Missense_Mutation_p.L554M|NRXN1_uc002rxc.1_Non-coding_Transcript	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	156	Extracellular (Potential).|Laminin G-like.				neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)											0.411348	171.030831	171.996289	58	83	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	50779824	50779824	11070	2	G	T	T	T	451	35	NRXN1	2	2
LRRTM4	80059	broad.mit.edu	37	2	77745683	77745683	+	Missense_Mutation	SNP	T	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:77745683T>C	uc002snr.2	-	c.1312A>G	c.(1312-1314)ATG>GTG	p.M438V	LRRTM4_uc002snq.2_Missense_Mutation_p.M438V|LRRTM4_uc002sns.2_Missense_Mutation_p.M438V|LRRTM4_uc002snt.2_Missense_Mutation_p.M439V	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	438	Helical; (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)										0.541667	117.310589	117.421001	39	33	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	77745683	77745683	9418	2	T	C	C	C	663	51	LRRTM4	4	4
ZPLD1	131368	broad.mit.edu	37	3	102189285	102189285	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:102189285G>T	uc003dvt.1	+	c.1029G>T	c.(1027-1029)TGG>TGT	p.W343C	ZPLD1_uc003dvs.1_Missense_Mutation_p.W327C|ZPLD1_uc011bhg.1_Missense_Mutation_p.W327C	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	327	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3														0.708333	49.536409	50.45833	17	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	102189285	102189285	18825	3	G	T	T	T	533	41	ZPLD1	2	2
CEP70	80321	broad.mit.edu	37	3	138219359	138219359	+	Silent	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:138219359G>A	uc003esl.2	-	c.1419C>T	c.(1417-1419)TTC>TTT	p.F473F	CEP70_uc011bmk.1_Silent_p.F453F|CEP70_uc011bml.1_Silent_p.F455F|CEP70_uc011bmm.1_Silent_p.F321F|CEP70_uc003esm.2_Silent_p.F473F	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	473					G2/M transition of mitotic cell cycle	cytosol|microtubule organizing center	protein binding				0														0.413146	272.579942	273.977851	88	125	KEEP	---	---	---	---	capture		Silent	SNP	138219359	138219359	3392	3	G	A	A	A	529	41	CEP70	2	2
LIPH	200879	broad.mit.edu	37	3	185251403	185251403	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:185251403C>T	uc003fpm.2	-	c.482G>A	c.(481-483)GGG>GAG	p.G161E	LIPH_uc010hyh.2_Missense_Mutation_p.G161E	NM_139248	NP_640341	Q8WWY8	LIPH_HUMAN	lipase, member H precursor	161					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			ovary(1)|pancreas(1)	2	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)											0.318841	61.135692	63.143098	22	47	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	185251403	185251403	9151	3	C	T	T	T	286	22	LIPH	2	2
HTR1F	3355	broad.mit.edu	37	3	88040430	88040430	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:88040430C>A	uc003dqr.2	+	c.531C>A	c.(529-531)GAC>GAA	p.D177E		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	177	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)									0.771429	89.035754	91.398001	27	8	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	88040430	88040430	7740	3	C	A	A	A	233	18	HTR1F	2	2
GABRG1	2565	broad.mit.edu	37	4	46125866	46125866	+	Missense_Mutation	SNP	C	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:46125866C>G	uc003gxb.2	-	c.65G>C	c.(64-66)AGG>ACG	p.R22T		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	22					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)										0.116279	5.461307	11.678086	5	38	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	46125866	46125866	6422	4	C	G	G	G	312	24	GABRG1	3	3
EPHA5	2044	broad.mit.edu	37	4	66231689	66231689	+	Missense_Mutation	SNP	C	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:66231689C>G	uc011cah.1	-	c.2014G>C	c.(2014-2016)GAA>CAA	p.E672Q	EPHA5_uc003hcx.2_Missense_Mutation_p.E603Q|EPHA5_uc003hcy.2_Missense_Mutation_p.E671Q|EPHA5_uc003hcz.2_Missense_Mutation_p.E649Q|EPHA5_uc011cai.1_Missense_Mutation_p.E650Q|EPHA5_uc003hda.2_Missense_Mutation_p.E672Q	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	671	Cytoplasmic (Potential).				cAMP-mediated signaling|ephrin receptor signaling pathway|neuron development|protein phosphorylation	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(12)|ovary(2)|central_nervous_system(1)	15										537	TSP Lung(17;0.13)			0.534884	156.462499	156.555014	46	40	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	66231689	66231689	5363	4	C	G	G	G	416	32	EPHA5	3	3
MUC7	4589	broad.mit.edu	37	4	71346861	71346861	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:71346861C>A	uc011cat.1	+	c.400C>A	c.(400-402)CAG>AAG	p.Q134K	MUC7_uc011cau.1_Missense_Mutation_p.Q134K|MUC7_uc003hfj.2_Missense_Mutation_p.Q134K	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	134	Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)	3			Lung(101;0.211)											0.391753	114.288327	115.262845	38	59	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	71346861	71346861	10375	4	C	A	A	A	273	21	MUC7	2	2
PDHA2	5161	broad.mit.edu	37	4	96761794	96761794	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:96761794G>A	uc003htr.3	+	c.493G>A	c.(493-495)GTC>ATC	p.V165I		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	165					glycolysis|oxidation-reduction process	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)									0.302083	70.237766	73.59886	29	67	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	96761794	96761794	12086	4	G	A	A	A	520	40	PDHA2	1	1
SEMA6A	57556	broad.mit.edu	37	5	115783135	115783135	+	Missense_Mutation	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:115783135G>A	uc003krx.3	-	c.2318C>T	c.(2317-2319)CCC>CTC	p.P773L	SEMA6A_uc010jck.2_Missense_Mutation_p.P756L|SEMA6A_uc011cwe.1_Missense_Mutation_p.P135L|SEMA6A_uc003krv.3_Missense_Mutation_p.P183L|SEMA6A_uc003krw.3_Missense_Mutation_p.P233L|SEMA6A_uc010jcj.2_Missense_Mutation_p.P300L	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	756	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)										0.475177	179.90345	179.995656	67	74	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	115783135	115783135	14525	5	G	A	A	A	559	43	SEMA6A	2	2
DNAH5	1767	broad.mit.edu	37	5	13717423	13717424	+	Splice_Site_DNP	DNP	CC	AA	AA			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:13717423_13717424CC>AA	uc003jfd.2	-	c.12705_splice	c.e73+1	p.K4235_splice	DNAH5_uc003jfc.2_Splice_Site_DNP_p.K403_splice	NM_001369	NP_001360			dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|breast(1)|central_nervous_system(1)|pancreas(1)	17	Lung NSC(4;0.00476)													0.40625	41.170351	41.415735	13	19	KEEP	---	---	---	---	capture		Splice_Site_DNP	DNP	13717423	13717424	4787	5	CC	AA	AA	AA	234	18	DNAH5	5	2
PCDHA2	56146	broad.mit.edu	37	5	140176284	140176284	+	Nonsense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140176284G>T	uc003lhd.2	+	c.1735G>T	c.(1735-1737)GAG>TAG	p.E579*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Nonsense_Mutation_p.E579*|PCDHA2_uc011czy.1_Nonsense_Mutation_p.E579*	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	579	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.534247	113.999757	114.072258	39	34	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	140176284	140176284	11944	5	G	T	T	T	585	45	PCDHA2	5	2
PCDHB12	56124	broad.mit.edu	37	5	140588899	140588899	+	Missense_Mutation	SNP	A	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140588899A>T	uc003liz.2	+	c.420A>T	c.(418-420)TTA>TTT	p.L140F	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	140	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)											0.529412	168.842736	168.918708	54	48	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	140588899	140588899	11957	5	A	T	T	T	193	15	PCDHB12	3	3
PCDHGB2	56103	broad.mit.edu	37	5	140741968	140741968	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:140741968G>T	uc003ljs.1	+	c.2266G>T	c.(2266-2268)GTT>TTT	p.V756F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.V756F|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	756	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.56338	260.273443	260.770094	80	62	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	140741968	140741968	11983	5	G	T	T	T	624	48	PCDHGB2	2	2
SLC6A7	6534	broad.mit.edu	37	5	149584134	149584134	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:149584134G>T	uc003lrr.2	+	c.1372G>T	c.(1372-1374)GCC>TCC	p.A458S		NM_014228	NP_055043	Q99884	SC6A7_HUMAN	solute carrier family 6, member 7	458						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity				0		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)									0.2	12.386407	15.871712	8	32	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	149584134	149584134	15186	5	G	T	T	T	494	38	SLC6A7	1	1
ADAM19	8728	broad.mit.edu	37	5	156964936	156964936	+	Silent	SNP	G	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:156964936G>C	uc003lwz.2	-	c.315C>G	c.(313-315)ACC>ACG	p.T105T	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Silent_p.T36T	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	105					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	7	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)											0.318182	39.533511	40.826919	14	30	KEEP	---	---	---	---	capture		Silent	SNP	156964936	156964936	241	5	G	C	C	C	600	47	ADAM19	3	3
FAF2	23197	broad.mit.edu	37	5	175923528	175923528	+	Missense_Mutation	SNP	A	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:175923528A>G	uc003mej.3	+	c.703A>G	c.(703-705)ATG>GTG	p.M235V		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	235					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1														0.435484	80.613257	80.838494	27	35	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	175923528	175923528	5567	5	A	G	G	G	104	8	FAF2	4	4
CDH10	1008	broad.mit.edu	37	5	24511534	24511534	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:24511534C>A	uc003jgr.1	-	c.904G>T	c.(904-906)GCT>TCT	p.A302S	CDH10_uc011cnu.1_Non-coding_Transcript	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	302	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)										0.2	58.097345	68.963779	26	104	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	24511534	24511534	3225	5	C	A	A	A	325	25	CDH10	2	2
PAPD4	167153	broad.mit.edu	37	5	78964730	78964730	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:78964730G>T	uc010jae.1	+	c.1087G>T	c.(1087-1089)GCT>TCT	p.A363S	PAPD4_uc003kgb.2_Missense_Mutation_p.A363S|PAPD4_uc010jaf.1_Missense_Mutation_p.A363S|PAPD4_uc003kga.2_Missense_Mutation_p.A359S|PAPD4_uc003kfz.2_Missense_Mutation_p.A320S	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	363					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm|nuclear RNA-directed RNA polymerase complex	ATP binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)										0.360784	275.78963	280.114364	92	163	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	78964730	78964730	11841	5	G	T	T	T	598	46	PAPD4	2	2
EDIL3	10085	broad.mit.edu	37	5	83525673	83525673	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:83525673C>A	uc003kio.1	-	c.226G>T	c.(226-228)GGT>TGT	p.G76C	EDIL3_uc003kip.1_Intron	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	76	EGF-like 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)										0.238806	38.765224	42.940916	16	51	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	83525673	83525673	5102	5	C	A	A	A	312	24	EDIL3	2	2
GRIK2	2898	broad.mit.edu	37	6	102516291	102516291	+	Nonsense_Mutation	SNP	A	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:102516291A>T	uc003pqp.3	+	c.2632A>T	c.(2632-2634)AAG>TAG	p.K878*	GRIK2_uc003pqo.3_3'UTR|GRIK2_uc010kcw.2_3'UTR	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	878	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|breast(1)|pancreas(1)	4		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)									0.627907	82.441716	83.073604	27	16	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	102516291	102516291	7053	6	A	T	T	T	169	13	GRIK2	5	3
RTN4IP1	84816	broad.mit.edu	37	6	107019974	107019974	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:107019974C>A	uc003prj.2	-	c.1088G>T	c.(1087-1089)CGG>CTG	p.R363L	RTN4IP1_uc010kdd.2_3'UTR|RTN4IP1_uc003prk.2_Missense_Mutation_p.R263L	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	363					oxidation-reduction process	mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)										0.754717	141.526603	144.660575	40	13	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	107019974	107019974	14209	6	C	A	A	A	299	23	RTN4IP1	1	1
C6orf89	221477	broad.mit.edu	37	6	36882185	36882185	+	Missense_Mutation	SNP	G	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:36882185G>C	uc003omw.2	+	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	C6orf89_uc003omv.2_Missense_Mutation_p.E71Q|C6orf89_uc003omx.2_Missense_Mutation_p.E177Q|C6orf89_uc011dtr.1_Missense_Mutation_p.E71Q|C6orf89_uc003omy.2_Missense_Mutation_p.E11Q	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	177						integral to membrane				ovary(1)	1														0.465517	90.020979	90.080849	27	31	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	36882185	36882185	2479	6	G	C	C	C	585	45	C6orf89	3	3
LRRC1	55227	broad.mit.edu	37	6	53785527	53785527	+	Missense_Mutation	SNP	G	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:53785527G>C	uc003pcd.1	+	c.1384G>C	c.(1384-1386)GAG>CAG	p.E462Q		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	462						cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)										0.351351	39.66342	40.38467	13	24	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	53785527	53785527	9339	6	G	C	C	C	533	41	LRRC1	3	3
MUC17	140453	broad.mit.edu	37	7	100680531	100680531	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:100680531C>A	uc003uxp.1	+	c.5834C>A	c.(5833-5835)ACC>AAC	p.T1945N	MUC17_uc010lho.1_Non-coding_Transcript	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1945	Extracellular (Potential).|30.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|breast(3)|lung(2)	19	Lung NSC(181;0.136)|all_lung(186;0.182)													0.262009	155.10053	166.836282	60	169	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100680531	100680531	10368	7	C	A	A	A	234	18	MUC17	2	2
MUC17	140453	broad.mit.edu	37	7	100682994	100682994	+	Missense_Mutation	SNP	C	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:100682994C>G	uc003uxp.1	+	c.8297C>G	c.(8296-8298)TCT>TGT	p.S2766C	MUC17_uc010lho.1_Non-coding_Transcript	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2766	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|44.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|breast(3)|lung(2)	19	Lung NSC(181;0.136)|all_lung(186;0.182)													0.540351	521.191418	521.590887	154	131	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100682994	100682994	10368	7	C	G	G	G	416	32	MUC17	3	3
VGF	7425	broad.mit.edu	37	7	100807902	100807902	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:100807902G>T	uc003uxx.3	-	c.223C>A	c.(223-225)CAG>AAG	p.Q75K		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	75					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)													0.5	8.82447	8.82447	3	3	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	100807902	100807902	17724	7	G	T	T	T	611	47	VGF	2	2
WNT2	7472	broad.mit.edu	37	7	116955207	116955207	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:116955207C>T	uc003viz.2	-	c.506G>A	c.(505-507)CGC>CAC	p.R169H	WNT2_uc003vja.2_Missense_Mutation_p.R73H	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	169					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|negative regulation of gene-specific transcription from RNA polymerase II promoter|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			central_nervous_system(2)|ovary(1)|breast(1)	4	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)										0.31	84.761714	87.937856	31	69	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	116955207	116955207	17960	7	C	T	T	T	351	27	WNT2	1	1
PLXNA4	91584	broad.mit.edu	37	7	131912276	131912276	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:131912276C>T	uc003vra.3	-	c.1816G>A	c.(1816-1818)GTG>ATG	p.V606M		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	606	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1														0.289474	27.612295	29.120426	11	27	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	131912276	131912276	12548	7	C	T	T	T	247	19	PLXNA4	1	1
FAM131B	9715	broad.mit.edu	37	7	143055984	143055984	+	Silent	SNP	C	G	G			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:143055984C>G	uc010lpa.2	-	c.402G>C	c.(400-402)GTG>GTC	p.V134V	FAM131B_uc010loz.2_Silent_p.V74V|FAM131B_uc003wct.2_Silent_p.V106V|FAM131B_uc003wcu.3_Silent_p.V106V|ZYX_uc011ktd.1_5'Flank	NM_001031690	NP_001026860	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform a	106											0	Melanoma(164;0.205)													0.405405	47.216042	47.505873	15	22	KEEP	---	---	---	---	capture		Silent	SNP	143055984	143055984	5637	7	C	G	G	G	314	25	FAM131B	3	3
DNAH11	8701	broad.mit.edu	37	7	21628977	21628977	+	Missense_Mutation	SNP	T	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:21628977T>C	uc003svc.2	+	c.2125T>C	c.(2125-2127)TTC>CTC	p.F709L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	709	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														0.25	58.4446	63.215091	21	63	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	21628977	21628977	4781	7	T	C	C	C	676	52	DNAH11	4	4
PKHD1L1	93035	broad.mit.edu	37	8	110454418	110454418	+	Missense_Mutation	SNP	A	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:110454418A>T	uc003yne.2	+	c.4387A>T	c.(4387-4389)ACA>TCA	p.T1463S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1463	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)											0.829268	115.474748	119.679889	34	7	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	110454418	110454418	12397	8	A	T	T	T	182	14	PKHD1L1	3	3
KIAA0196	9897	broad.mit.edu	37	8	126085512	126085512	+	Silent	SNP	G	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:126085512G>A	uc003yrt.2	-	c.1033C>T	c.(1033-1035)CTA>TTA	p.L345L	KIAA0196_uc011lir.1_Silent_p.L197L	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	345					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)											0.188406	31.443506	37.705576	13	56	KEEP	---	---	---	---	capture		Silent	SNP	126085512	126085512	8468	8	G	A	A	A	425	33	KIAA0196	2	2
DLGAP2	9228	broad.mit.edu	37	8	1496873	1496873	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:1496873C>A	uc003wpl.2	+	c.14C>A	c.(13-15)TCC>TAC	p.S5Y	DLGAP2_uc003wpm.2_Missense_Mutation_p.S5Y	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	84					nerve-nerve synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)										0.4	14.940746	15.073482	6	9	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	1496873	1496873	4740	8	C	A	A	A	390	30	DLGAP2	2	2
DLGAP2	9228	broad.mit.edu	37	8	1497432	1497432	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:1497432C>A	uc003wpl.2	+	c.573C>A	c.(571-573)CAC>CAA	p.H191Q	DLGAP2_uc003wpm.2_Missense_Mutation_p.H191Q	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	270					nerve-nerve synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)										0.555556	28.744181	28.791816	10	8	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	1497432	1497432	4740	8	C	A	A	A	246	19	DLGAP2	1	1
DLGAP2	9228	broad.mit.edu	37	8	1497586	1497586	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:1497586G>T	uc003wpl.2	+	c.727G>T	c.(727-729)GTG>TTG	p.V243L	DLGAP2_uc003wpm.2_Missense_Mutation_p.V243L	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	322					nerve-nerve synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)										0.412281	141.694107	142.460428	47	67	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	1497586	1497586	4740	8	G	T	T	T	520	40	DLGAP2	1	1
NEFL	4747	broad.mit.edu	37	8	24813612	24813612	+	Missense_Mutation	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:24813612C>T	uc003xee.2	-	c.418G>A	c.(418-420)GAG>AAG	p.E140K		NM_006158	NP_006149	P07196	NFL_HUMAN	neurofilament, light polypeptide 68kDa	140	Rod.|Coil 1B.				anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)										0.6	18.037298	18.122256	6	4	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	24813612	24813612	10714	8	C	T	T	T	403	31	NEFL	1	1
NRG1	3084	broad.mit.edu	37	8	32453386	32453386	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:32453386G>T	uc003xiu.2	+	c.141G>T	c.(139-141)TCG>TCT	p.S47S	NRG1_uc003xip.2_Silent_p.S262S|NRG1_uc003xir.2_Silent_p.S47S|NRG1_uc010lvl.2_Silent_p.S47S|NRG1_uc010lvm.2_Silent_p.S47S|NRG1_uc010lvn.2_Silent_p.S47S|NRG1_uc003xis.2_Silent_p.S47S|NRG1_uc011lbf.1_Silent_p.S47S|NRG1_uc010lvo.2_Silent_p.S47S|NRG1_uc003xiw.2_Silent_p.S47S|NRG1_uc003xit.2_Silent_p.S47S|NRG1_uc003xiv.2_Silent_p.S47S|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Silent_p.S13S|NRG1_uc010lvq.2_Silent_p.S13S	NM_013956	NP_039250	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-beta1	47	Extracellular (Potential).|Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)										0.626374	192.302387	193.585326	57	34	KEEP	---	---	---	---	capture		Silent	SNP	32453386	32453386	11052	8	G	T	T	T	507	39	NRG1	1	1
POTEA	340441	broad.mit.edu	37	8	43159892	43159892	+	Missense_Mutation	SNP	C	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:43159892C>A	uc003xpz.1	+	c.884C>A	c.(883-885)TCT>TAT	p.S295Y	POTEA_uc003xqa.1_Missense_Mutation_p.S249Y	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	295										ovary(1)	1														0.533333	120.696558	120.768621	40	35	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43159892	43159892	12690	8	C	A	A	A	416	32	POTEA	2	2
CHD7	55636	broad.mit.edu	37	8	61777733	61777734	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:61777733_61777734GG>TT	uc003xue.2	+	c.8235_8236GG>TT	c.(8233-8238)CTGGTG>CTTTTG	p.V2746L		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2746					central nervous system development|chromatin assembly or disassembly|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	chromatin|nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|lung(1)|breast(1)|pancreas(1)	8		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)											0.4	12.398068	12.485513	4	6	KEEP	---	---	---	---	capture		Missense_Mutation	DNP	61777733	61777734	3464	8	GG	TT	TT	TT	600	47	CHD7	2	2
LHX3	8022	broad.mit.edu	37	9	139091689	139091689	+	Missense_Mutation	SNP	T	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:139091689T>C	uc004cgz.2	-	c.304A>G	c.(304-306)ATC>GTC	p.I102V	LHX3_uc004cha.2_Missense_Mutation_p.I97V	NM_014564	NP_055379	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform b	97	LIM zinc-binding 2.				inner ear development|organ morphogenesis|regulation of transcription, DNA-dependent	nucleus	RNA polymerase II transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)										0.7	17.587415	17.932315	7	3	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	139091689	139091689	9098	9	T	C	C	C	663	51	LHX3	4	4
FBXO10	26267	broad.mit.edu	37	9	37537272	37537272	+	Silent	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:37537272C>T	uc004aac.2	-	c.1302G>A	c.(1300-1302)AAG>AAA	p.K434K	FBXO10_uc004aab.2_Silent_p.K418K|FBXO10_uc004aad.2_Intron	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	418						ubiquitin ligase complex	ubiquitin-protein ligase activity				0				GBM - Glioblastoma multiforme(29;0.0107)										0.393939	41.377672	41.699286	13	20	KEEP	---	---	---	---	capture		Silent	SNP	37537272	37537272	5963	9	C	T	T	T	311	24	FBXO10	2	2
TMEM2	23670	broad.mit.edu	37	9	74340552	74340552	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:74340552G>T	uc011lsa.1	-	c.2123C>A	c.(2122-2124)CCA>CAA	p.P708Q	TMEM2_uc010mos.2_Missense_Mutation_p.P645Q|TMEM2_uc011lsb.1_Non-coding_Transcript	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	708						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)										0.338028	67.379948	69.026263	24	47	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	74340552	74340552	16656	9	G	T	T	T	611	47	TMEM2	2	2
NXF2B	728343	broad.mit.edu	37	X	101623732	101623732	+	Silent	SNP	C	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:101623732C>T	uc004ejb.3	-	c.630G>A	c.(628-630)AAG>AAA	p.K210K	NXF2B_uc004eiz.3_Silent_p.K122K|NXF2B_uc004eja.3_Silent_p.K210K|NXF2_uc004eiy.3_Silent_p.K210K	NM_001099686	NP_001093156	Q9GZY0	NXF2_HUMAN	nuclear RNA export factor 2B	210					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|RNA binding			ovary(1)	1														0.352941	54.034459	55.007212	18	33	KEEP	---	---	---	---	capture		Silent	SNP	101623732	101623732	11189	23	C	T	T	T	363	28	NXF2B	2	2
GPR112	139378	broad.mit.edu	37	X	135428901	135428901	+	Silent	SNP	T	C	C			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:135428901T>C	uc004ezu.1	+	c.3036T>C	c.(3034-3036)ACT>ACC	p.T1012T	GPR112_uc010nsb.1_Silent_p.T807T|GPR112_uc010nsc.1_Silent_p.T779T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1012	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	11	Acute lymphoblastic leukemia(192;0.000127)									487				0.844262	374.987403	388.787012	103	19	KEEP	---	---	---	---	capture		Silent	SNP	135428901	135428901	6903	23	T	C	C	C	691	54	GPR112	4	4
MAMLD1	10046	broad.mit.edu	37	X	149638350	149638350	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:149638350G>T	uc004fee.1	+	c.505G>T	c.(505-507)GTG>TTG	p.V169L	MAMLD1_uc011mxt.1_Missense_Mutation_p.V131L|MAMLD1_uc011mxu.1_Missense_Mutation_p.V144L|MAMLD1_uc011mxv.1_Missense_Mutation_p.V144L|MAMLD1_uc011mxw.1_Missense_Mutation_p.V96L	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	169					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)													0.893617	149.585179	156.821113	42	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	149638350	149638350	9591	23	G	T	T	T	520	40	MAMLD1	1	1
MAGEA6	4105	broad.mit.edu	37	X	151869776	151869776	+	Missense_Mutation	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:151869776G>T	uc004ffq.1	+	c.466G>T	c.(466-468)GAT>TAT	p.D156Y	MAGEA6_uc004ffr.1_Missense_Mutation_p.D156Y|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	156	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)													0.871429	201.397205	210.794225	61	9	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	151869776	151869776	9549	23	G	T	T	T	481	37	MAGEA6	1	1
FAM47A	158724	broad.mit.edu	37	X	34150162	34150162	+	Silent	SNP	G	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:34150162G>T	uc004ddg.2	-	c.234C>A	c.(232-234)CTC>CTA	p.L78L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	78										ovary(4)|central_nervous_system(1)	5														0.307692	48.864191	51.014312	20	45	KEEP	---	---	---	---	capture		Silent	SNP	34150162	34150162	5790	23	G	T	T	T	522	41	FAM47A	2	2
AMELY	266	broad.mit.edu	37	Y	6736166	6736166	+	Missense_Mutation	SNP	A	T	T			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chrY:6736166A>T	uc004fra.1	-	c.527T>A	c.(526-528)ATG>AAG	p.M176K	AMELY_uc004fqz.2_Missense_Mutation_p.M162K	NM_001143	NP_001134	Q99218	AMELY_HUMAN	amelogenin, Y-linked precursor	176					biomineral tissue development	extracellular matrix part|proteinaceous extracellular matrix	structural constituent of tooth enamel				0														0.5	6.750228	6.750227	2	2	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	6736166	6736166	573	24	A	T	T	T	104	8	AMELY	3	3
KCNK10	54207	broad.mit.edu	37	14	88652098	88652098	+	Frame_Shift_Del	DEL	G	-	-			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:88652098_88652098delG	uc001xwm.2	-	c.1413_1413delC	c.(1411-1413)CCCfs	p.P471fs	KCNK10_uc001xwn.2_Frame_Shift_Del_p.P471fs|KCNK10_uc001xwo.2_Frame_Shift_Del_p.P466fs	NM_138318	NP_612191	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	466	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|pancreas(1)	3														0.36			67	121		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	88652098	88652098	8364	14	G	-	-	-	496	39	KCNK10	5	5
PITPNM3	83394	broad.mit.edu	37	17	6358848	6358848	+	Frame_Shift_Del	DEL	G	-	-			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:6358848_6358848delG	uc002gdd.3	-	c.2735_2735delC	c.(2734-2736)GCGfs	p.A912fs	PITPNM3_uc010cln.2_Frame_Shift_Del_p.A876fs|PITPNM3_uc010clm.2_Frame_Shift_Del_p.A395fs|PITPNM3_uc002gdc.3_Frame_Shift_Del_p.A503fs	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	912					phosphatidylinositol metabolic process|response to stimulus|visual perception	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)										0.36			13	23		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	6358848	6358848	12376	17	G	-	-	-	494	38	PITPNM3	5	5
STK11	6794	broad.mit.edu	37	19	1221313	1221314	+	Frame_Shift_Ins	INS	-	C	C	rs67873004		TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:1221313_1221314insC	uc002lrl.1	+	c.836_837insC	c.(835-837)GGCfs	p.G279fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	279	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|protein phosphorylation|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.P281fs*6(2)|p.G279F(1)|p.Y246fs*3(1)		lung(162)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|ovary(4)|stomach(3)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|breast(1)|oesophagus(1)|prostate(1)|kidney(1)	252		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)				14	p.G279fs(TE4-Tumor)|p.G279fs(2313287-Tumor)|p.G279fs(G361-Tumor)|p.G279fs(HEC151-Tumor)|p.G279fs(TOV21G-Tumor)|p.G279fs(NCIH2122-Tumor)|p.G279fs(SNU324-Tumor)	1341	TSP Lung(3;<1E-8)			0.55			6	5		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	1221313	1221314	15807	19	-	C	C	C	546	42	STK11	5	5
CACNA1A	773	broad.mit.edu	37	19	13418663	13418663	+	Frame_Shift_Del	DEL	T	-	-			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:13418663_13418663delT	uc002mwy.3	-	c.1919_1919delA	c.(1918-1920)AATfs	p.N640fs	CACNA1A_uc010dzc.2_Frame_Shift_Del_p.N166fs|CACNA1A_uc010dze.2_Frame_Shift_Del_p.N641fs|CACNA1A_uc010xne.1_Frame_Shift_Del_p.N166fs	NM_001127222	NP_001120694	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 4	641	Extracellular (Potential).|II.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)									0.80			55	14		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	13418663	13418663	2654	19	T	-	-	-	676	52	CACNA1A	5	5
DEFB115	245929	broad.mit.edu	37	20	29847303	29847304	+	Frame_Shift_Ins	INS	-	A	A			TCGA-64-5774-01	TCGA-64-5774-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:29847303_29847304insA	uc002wvp.1	+	c.135_136insA	c.(133-138)TGCAGGfs	p.C45fs		NM_001037730	NP_001032819	Q30KQ5	DB115_HUMAN	beta-defensin 115 precursor	45_46					defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)											0.41			21	30		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	29847303	29847304	4581	20	-	A	A	A	324	25	DEFB115	5	5
