Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	Oncotatorv0393GAF20hg19Feb2011dbSNPbuild132UniProtRelease2011_6	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	newbase	context_orig	context65	gene_name	categ	categ_ignoring_null_categ
FAM178A	55719	broad.mit.edu	37	10	102690783	102690783	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:102690783C>T	uc001krs.2	+	c.2384C>T	c.(2383-2385)TCT>TTT	p.S795F	FAM178A_uc001krt.3_Missense_Mutation_p.S795F	NM_001136123	NP_001129595	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 2	795											0														0.082192	13.083082	64.933008	24	268	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	102690783	102690783	5709	10	C	T	T	T	416	32	FAM178A	2	2
COL17A1	1308	broad.mit.edu	37	10	105801076	105801076	+	Missense_Mutation	SNP	G	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:105801076G>T	uc001kxr.2	-	c.2632C>A	c.(2632-2634)CCC>ACC	p.P878T		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	878	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane				ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)										0.117647	8.316544	15.642613	6	45	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	105801076	105801076	3812	10	G	T	T	T	572	44	COL17A1	2	2
PNLIPRP3	119548	broad.mit.edu	37	10	118228714	118228714	+	Silent	SNP	T	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:118228714T>C	uc001lcl.3	+	c.945T>C	c.(943-945)TGT>TGC	p.C315C		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	315					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)										0.146341	57.488112	77.202132	24	140	KEEP	---	---	---	---	capture		Silent	SNP	118228714	118228714	12578	10	T	C	C	C	777	60	PNLIPRP3	4	4
ST8SIA6	338596	broad.mit.edu	37	10	17363049	17363049	+	Missense_Mutation	SNP	C	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:17363049C>A	uc001ipd.2	-	c.1025G>T	c.(1024-1026)GGA>GTA	p.G342V	ST8SIA6_uc010qce.1_Non-coding_Transcript	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	342	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1														0.325871	373.682716	384.499322	131	271	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	17363049	17363049	15754	10	C	A	A	A	390	30	ST8SIA6	2	2
MAP3K8	1326	broad.mit.edu	37	10	30748249	30748249	+	Silent	SNP	G	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:30748249G>C	uc001ivi.1	+	c.1092G>C	c.(1090-1092)CTG>CTC	p.L364L	MAP3K8_uc009xlf.1_Silent_p.L364L|MAP3K8_uc001ivj.1_Silent_p.L364L	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	364	Protein kinase.				cell cycle|protein phosphorylation|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)								197				0.070707	1.842636	20.657491	7	92	KEEP	---	---	---	---	capture		Silent	SNP	30748249	30748249	9639	10	G	C	C	C	574	45	MAP3K8	3	3
MAP3K8	1326	broad.mit.edu	37	10	30748321	30748321	+	Silent	SNP	G	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:30748321G>C	uc001ivi.1	+	c.1164G>C	c.(1162-1164)CTG>CTC	p.L388L	MAP3K8_uc009xlf.1_Silent_p.L388L|MAP3K8_uc001ivj.1_Silent_p.L388L	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	388	Protein kinase.				cell cycle|protein phosphorylation|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)								197				0.109375	10.877974	20.547808	7	57	KEEP	---	---	---	---	capture		Silent	SNP	30748321	30748321	9639	10	G	C	C	C	574	45	MAP3K8	3	3
HSD17B12	51144	broad.mit.edu	37	11	43819909	43819909	+	Missense_Mutation	SNP	A	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:43819909A>T	uc001mxq.3	+	c.323A>T	c.(322-324)GAC>GTC	p.D108V		NM_016142	NP_057226	Q53GQ0	DHB12_HUMAN	hydroxysteroid (17-beta) dehydrogenase 12	108					long-chain fatty-acyl-CoA biosynthetic process|oxidation-reduction process|steroid biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	estradiol 17-beta-dehydrogenase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity				0						Ovarian(58;548 1143 13948 16572 34258)								0.299383	288.150707	299.801408	97	227	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43819909	43819909	7676	11	A	T	T	T	130	10	HSD17B12	3	3
KIF5A	3798	broad.mit.edu	37	12	57975228	57975228	+	Missense_Mutation	SNP	C	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:57975228C>A	uc001sor.1	+	c.2786C>A	c.(2785-2787)GCA>GAA	p.A929E	KIF5A_uc010srr.1_Missense_Mutation_p.A840E	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	929	Globular.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)	2														0.210526	40.058834	45.949163	16	60	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	57975228	57975228	8616	12	C	A	A	A	325	25	KIF5A	2	2
GAPDH	2597	broad.mit.edu	37	12	6646512	6646512	+	Missense_Mutation	SNP	G	T	T	rs77154254		TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr12:6646512G>T	uc001qop.1	+	c.481G>T	c.(481-483)GCC>TCC	p.A161S	GAPDH_uc009zep.1_Missense_Mutation_p.A119S|GAPDH_uc001qoq.1_Missense_Mutation_p.A86S|GAPDH_uc001qor.1_Missense_Mutation_p.A120S|GAPDH_uc001qos.1_Missense_Mutation_p.A161S|GAPDH_uc001qot.1_Missense_Mutation_p.A161S|GAPDH_uc001qou.1_Missense_Mutation_p.A120S|GAPDH_uc001qov.1_Missense_Mutation_p.A119S|GAPDH_uc001qow.1_Missense_Mutation_p.A114S|GAPDH_uc001qox.1_5'UTR	NM_002046	NP_002037	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	161					gluconeogenesis|glycolysis|neuron apoptosis|oxidation-reduction process|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding				0					NADH(DB00157)									0.176471	6.714808	8.391417	3	14	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	6646512	6646512	6500	12	G	T	T	T	546	42	GAPDH	2	2
MYO16	23026	broad.mit.edu	37	13	109779804	109779804	+	Silent	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr13:109779804G>A	uc010agk.1	+	c.3957G>A	c.(3955-3957)CCG>CCA	p.P1319P	MYO16_uc001vqt.1_Silent_p.P1297P|MYO16_uc010tjh.1_Silent_p.P809P	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1297					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(5)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	9	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)											0.428571	18.348293	18.41047	6	8	KEEP	---	---	---	---	capture		Silent	SNP	109779804	109779804	10459	13	G	A	A	A	483	38	MYO16	1	1
C14orf45	80127	broad.mit.edu	37	14	74495917	74495917	+	Missense_Mutation	SNP	A	G	G			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:74495917A>G	uc010tup.1	+	c.316A>G	c.(316-318)ACA>GCA	p.T106A	C14orf45_uc001xpm.1_5'Flank	NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	106	Potential.										0				BRCA - Breast invasive adenocarcinoma(234;0.00351)										0.15	7.611444	9.959993	3	17	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	74495917	74495917	1825	14	A	G	G	G	26	2	C14orf45	4	4
KCNK13	56659	broad.mit.edu	37	14	90650622	90650622	+	Nonsense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:90650622C>T	uc001xye.1	+	c.502C>T	c.(502-504)CGA>TGA	p.R168*		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	168	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		all_cancers(154;0.186)												0.17284	25.675084	33.806932	14	67	KEEP	---	---	---	---	capture		Nonsense_Mutation	SNP	90650622	90650622	8366	14	C	T	T	T	243	19	KCNK13	5	1
THBS1	7057	broad.mit.edu	37	15	39881468	39881468	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:39881468C>T	uc001zkh.2	+	c.1839C>T	c.(1837-1839)CCC>CCT	p.P613P	THBS1_uc010bbi.2_Silent_p.P85P	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	613	EGF-like 2; calcium-binding (Potential).				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of oxygen and reactive oxygen species metabolic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			central_nervous_system(3)|ovary(2)	5		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)									0.170732	30.599612	39.008021	14	68	KEEP	---	---	---	---	capture		Silent	SNP	39881468	39881468	16381	15	C	T	T	T	288	23	THBS1	1	1
MAP1A	4130	broad.mit.edu	37	15	43818488	43818488	+	Missense_Mutation	SNP	C	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:43818488C>A	uc001zrt.2	+	c.4817C>A	c.(4816-4818)GCC>GAC	p.A1606D		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1606						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)	8		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)									0.115385	7.350372	14.894775	6	46	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43818488	43818488	9610	15	C	A	A	A	338	26	MAP1A	2	2
MYO5A	4644	broad.mit.edu	37	15	52643464	52643464	+	Missense_Mutation	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:52643464G>A	uc002aby.2	-	c.3836C>T	c.(3835-3837)GCC>GTC	p.A1279V	MYO5A_uc002abx.3_Missense_Mutation_p.A1279V|MYO5A_uc010ugd.1_Missense_Mutation_p.A31V|MYO5A_uc002aca.1_Missense_Mutation_p.A31V|MYO5A_uc002acb.1_Missense_Mutation_p.A31V|MYO5A_uc002acc.1_Missense_Mutation_p.A31V	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1279					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)										0.166667	11.15671	14.316206	5	25	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	52643464	52643464	10473	15	G	A	A	A	546	42	MYO5A	2	2
UNC45A	55898	broad.mit.edu	37	15	91485697	91485697	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:91485697C>T	uc002bqg.2	+	c.718C>T	c.(718-720)CGG>TGG	p.R240W	UNC45A_uc002bqd.2_Missense_Mutation_p.R225W|UNC45A_uc010uqo.1_Missense_Mutation_p.R232W|UNC45A_uc010uqp.1_Non-coding_Transcript|UNC45A_uc010uqq.1_Missense_Mutation_p.R240W	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	240					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)											0.117647	5.702244	10.56506	4	30	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	91485697	91485697	17546	15	C	T	T	T	399	31	UNC45A	1	1
TTC23	64927	broad.mit.edu	37	15	99696405	99696405	+	Missense_Mutation	SNP	C	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr15:99696405C>A	uc002bur.2	-	c.1091G>T	c.(1090-1092)GGA>GTA	p.G364V	TTC23_uc002bus.2_Missense_Mutation_p.G364V|TTC23_uc002but.2_Missense_Mutation_p.G364V|TTC23_uc002buu.2_Missense_Mutation_p.G364V|TTC23_uc002buv.2_Missense_Mutation_p.G364V|TTC23_uc002bux.2_Missense_Mutation_p.G364V|TTC23_uc002buw.2_Missense_Mutation_p.G364V|TTC23_uc010boq.2_Non-coding_Transcript|TTC23_uc002buy.2_Missense_Mutation_p.G364V|TTC23_uc010bor.2_Missense_Mutation_p.G364V|TTC23_uc002buz.2_Missense_Mutation_p.G364V	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	364	TPR 4.						binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)											0.14	10.589909	16.849349	7	43	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	99696405	99696405	17244	15	C	A	A	A	390	30	TTC23	2	2
C16orf91	283951	broad.mit.edu	37	16	1479308	1479308	+	Missense_Mutation	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:1479308G>A	uc010uvd.1	-	c.38C>T	c.(37-39)TCC>TTC	p.S13F		NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	Error:Variant_position_missing_in_Q4G0I0_after_alignment						integral to membrane					0														0.190476	9.487373	11.368223	4	17	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	1479308	1479308	1897	16	G	A	A	A	533	41	C16orf91	2	2
GPR139	124274	broad.mit.edu	37	16	20043736	20043736	+	Missense_Mutation	SNP	A	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:20043736A>T	uc002dgu.1	-	c.383T>A	c.(382-384)ATC>AAC	p.I128N	GPR139_uc010vaw.1_Missense_Mutation_p.I35N	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	128	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2														0.181087	214.742198	262.257678	90	407	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	20043736	20043736	6922	16	A	T	T	T	156	12	GPR139	3	3
SPIRE2	84501	broad.mit.edu	37	16	89911744	89911744	+	Missense_Mutation	SNP	G	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:89911744G>T	uc002foz.1	+	c.259G>T	c.(259-261)GTC>TTC	p.V87F	SPIRE2_uc010civ.1_Missense_Mutation_p.V2F|SPIRE2_uc010ciw.1_Missense_Mutation_p.V87F	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	87	KIND.				transport	cytoplasm|cytoskeleton	actin binding|zinc ion binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)										0.125	6.075471	10.474251	4	28	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	89911744	89911744	15585	16	G	T	T	T	572	44	SPIRE2	2	2
CCDC144A	9720	broad.mit.edu	37	17	16612580	16612580	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:16612580C>T	uc002gqk.1	+	c.1209C>T	c.(1207-1209)TGC>TGT	p.C403C	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	403											0														0.576271	231.205327	231.802557	68	50	KEEP	---	---	---	---	capture		Silent	SNP	16612580	16612580	2897	17	C	T	T	T	350	27	CCDC144A	1	1
SLFN11	91607	broad.mit.edu	37	17	33680037	33680037	+	Missense_Mutation	SNP	C	G	G			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:33680037C>G	uc010ctp.2	-	c.2044G>C	c.(2044-2046)GGG>CGG	p.G682R	SLFN11_uc010ctq.2_Missense_Mutation_p.G682R|SLFN11_uc002hjh.3_Missense_Mutation_p.G682R|SLFN11_uc002hjg.3_Missense_Mutation_p.G682R|SLFN11_uc010ctr.2_Missense_Mutation_p.G682R	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	682						nucleus	ATP binding			large_intestine(1)|ovary(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)										0.05618	-20.414198	34.888461	15	252	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	33680037	33680037	15230	17	C	G	G	G	273	21	SLFN11	3	3
GSG2	83903	broad.mit.edu	37	17	3628194	3628194	+	Missense_Mutation	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:3628194G>A	uc002fwp.2	+	c.965G>A	c.(964-966)CGC>CAC	p.R322H	ITGAE_uc002fwo.3_Intron|ITGAE_uc002fwn.3_5'Flank	NM_031965	NP_114171	Q8TF76	HASP_HUMAN	haspin	322					cell cycle|chromatin modification|intracellular protein kinase cascade|protein phosphorylation	nucleus	ATP binding|protein serine/threonine kinase activity				0										41				0.142857	6.02666	8.594227	3	18	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	3628194	3628194	7102	17	G	A	A	A	494	38	GSG2	1	1
KLHL10	317719	broad.mit.edu	37	17	40004382	40004382	+	Silent	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:40004382G>A	uc010cxr.2	+	c.1650G>A	c.(1648-1650)AAG>AAA	p.K550K	KLHL10_uc010wfw.1_Silent_p.K462K	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	kelch-like 10	550	Kelch 6.					cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)												0.093023	8.796401	30.292871	12	117	KEEP	---	---	---	---	capture		Silent	SNP	40004382	40004382	8678	17	G	A	A	A	425	33	KLHL10	2	2
USP6	9098	broad.mit.edu	37	17	5041502	5041502	+	Missense_Mutation	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:5041502G>A	uc002gau.1	+	c.1012G>A	c.(1012-1014)GTG>ATG	p.V338M	USP6_uc002gav.1_Missense_Mutation_p.V338M|USP6_uc010ckz.1_De_novo_Start_OutOfFrame	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	338					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1										464				0.14	10.991266	17.249854	7	43	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	5041502	5041502	17650	17	G	A	A	A	520	40	USP6	1	1
MYOM1	8736	broad.mit.edu	37	18	3102545	3102545	+	Missense_Mutation	SNP	C	G	G			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr18:3102545C>G	uc002klp.2	-	c.3502G>C	c.(3502-3504)GAG>CAG	p.E1168Q	MYOM1_uc002klq.2_Missense_Mutation_p.E1072Q	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1168	Ig-like C2-type 3.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5														0.233728	235.585831	257.491405	79	259	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	3102545	3102545	10486	18	C	G	G	G	403	31	MYOM1	3	3
ELOF1	84337	broad.mit.edu	37	19	11665121	11665121	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:11665121C>T	uc002msd.1	-	c.105G>A	c.(103-105)AAG>AAA	p.K35K	ELOF1_uc002mse.1_Silent_p.K14K	NM_032377	NP_115753	P60002	ELOF1_HUMAN	elongation factor 1 homolog (ELF1, S.	14					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding				0														0.197368	39.080923	45.563096	15	61	KEEP	---	---	---	---	capture		Silent	SNP	11665121	11665121	5264	19	C	T	T	T	415	32	ELOF1	2	2
LYL1	4066	broad.mit.edu	37	19	13211508	13211508	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:13211508C>T	uc002mwi.2	-	c.390G>A	c.(388-390)AAG>AAA	p.K130K		NM_005583	NP_005574	P12980	LYL1_HUMAN	lymphoblastic leukemia derived sequence 1	130					B cell differentiation|blood vessel maturation|definitive hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|transcription activator activity				0			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)							10				0.106061	7.27246	17.449758	7	59	KEEP	---	---	---	---	capture		Silent	SNP	13211508	13211508	9483	19	C	T	T	T	363	28	LYL1	2	2
ANKRD27	84079	broad.mit.edu	37	19	33140660	33140660	+	Silent	SNP	G	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:33140660G>T	uc002ntn.1	-	c.141C>A	c.(139-141)ATC>ATA	p.I47I	ANKRD27_uc002nto.1_Silent_p.I47I	NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	47					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(110;0.137)													0.07377	-1.127871	21.648818	9	113	KEEP	---	---	---	---	capture		Silent	SNP	33140660	33140660	660	19	G	T	T	T	525	41	ANKRD27	2	2
TEX101	83639	broad.mit.edu	37	19	43922153	43922153	+	Missense_Mutation	SNP	C	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:43922153C>A	uc002owk.2	+	c.569C>A	c.(568-570)ACT>AAT	p.T190N	TEX101_uc010xwo.1_Missense_Mutation_p.T172N	NM_031451	NP_113639	Q9BY14	TX101_HUMAN	testis expressed 101 isoform 1	172						anchored to membrane|plasma membrane				ovary(1)	1		Prostate(69;0.0199)												0.076142	1.662125	37.928722	15	182	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	43922153	43922153	16300	19	C	A	A	A	260	20	TEX101	2	2
ERCC2	2068	broad.mit.edu	37	19	45860756	45860756	+	Missense_Mutation	SNP	G	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:45860756G>T	uc002pbj.2	-	c.1353C>A	c.(1351-1353)TTC>TTA	p.F451L	ERCC2_uc002pbh.2_Missense_Mutation_p.F14L|ERCC2_uc002pbi.2_Missense_Mutation_p.F144L|ERCC2_uc010ejz.2_Missense_Mutation_p.F373L|ERCC2_uc002pbk.2_Missense_Mutation_p.F427L	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	451	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(1)|pancreas(1)	2		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)						447				0.371429	37.761716	38.271583	13	22	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	45860756	45860756	5406	19	G	T	T	T	529	41	ERCC2	2	2
ZNF671	79891	broad.mit.edu	37	19	58232868	58232868	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:58232868C>T	uc002qpz.3	-	c.586G>A	c.(586-588)GCA>ACA	p.A196T	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.A119T|ZNF671_uc010yhf.1_Missense_Mutation_p.A98T	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	196	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)										0.08	1.192625	14.685782	6	69	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	58232868	58232868	18673	19	C	T	T	T	338	26	ZNF671	2	2
CD1A	909	broad.mit.edu	37	1	158225083	158225083	+	Missense_Mutation	SNP	C	A	A	rs116290813	by1000genomes	TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:158225083C>A	uc001frt.2	+	c.268C>A	c.(268-270)CGC>AGC	p.R90S		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	90	Extracellular (Potential).|Glycolipid binding.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)	2	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)									0.155979	206.544047	271.676935	90	487	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	158225083	158225083	3101	1	C	A	A	A	247	19	CD1A	1	1
ARHGEF10L	55160	broad.mit.edu	37	1	17914122	17914122	+	Missense_Mutation	SNP	G	A	A	rs35497285	byFrequency;by1000genomes	TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:17914122G>A	uc001ban.2	+	c.205G>A	c.(205-207)GAC>AAC	p.D69N	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.D69N|ARHGEF10L_uc001bao.2_Missense_Mutation_p.D69N|ARHGEF10L_uc001bap.2_Missense_Mutation_p.D69N|ARHGEF10L_uc010ocr.1_5'Flank	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	69					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)										0.070175	-4.498085	17.245102	8	106	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	17914122	17914122	909	1	G	A	A	A	533	41	ARHGEF10L	2	2
PRG4	10216	broad.mit.edu	37	1	186277099	186277099	+	Missense_Mutation	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:186277099G>A	uc001gru.3	+	c.2248G>A	c.(2248-2250)GCT>ACT	p.A750T	PRG4_uc001grt.3_Missense_Mutation_p.A709T|PRG4_uc009wyl.2_Missense_Mutation_p.A657T|PRG4_uc009wym.2_Missense_Mutation_p.A616T|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	750	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|47; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity				0														0.210526	9.789108	11.262218	4	15	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	186277099	186277099	12924	1	G	A	A	A	494	38	PRG4	1	1
LAMB3	3914	broad.mit.edu	37	1	209797336	209797336	+	Silent	SNP	G	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:209797336G>C	uc001hhg.2	-	c.1986C>G	c.(1984-1986)CTC>CTG	p.L662L	LAMB3_uc009xco.2_Silent_p.L662L|LAMB3_uc001hhh.2_Silent_p.L662L|LAMB3_uc010psl.1_Non-coding_Transcript	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	662	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|large_intestine(1)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(81;0.0519)										0.26087	40.281492	42.660364	12	34	KEEP	---	---	---	---	capture		Silent	SNP	209797336	209797336	8935	1	G	C	C	C	522	41	LAMB3	3	3
KCNH1	3756	broad.mit.edu	37	1	211280627	211280627	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:211280627C>T	uc001hib.2	-	c.172G>A	c.(172-174)GCA>ACA	p.A58T	KCNH1_uc001hic.2_Missense_Mutation_p.A58T	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	58	Cytoplasmic (Potential).|PAS.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)										0.34	156.978745	160.373413	51	99	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	211280627	211280627	8336	1	C	T	T	T	338	26	KCNH1	2	2
RYR2	6262	broad.mit.edu	37	1	237777703	237777703	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:237777703C>T	uc001hyl.1	+	c.5275C>T	c.(5275-5277)CCA>TCA	p.P1759S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1759	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)											0.099398	27.781584	80.989398	33	299	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	237777703	237777703	14249	1	C	T	T	T	338	26	RYR2	2	2
SFRS4	6429	broad.mit.edu	37	1	29475178	29475178	+	Missense_Mutation	SNP	G	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:29475178G>C	uc001bro.2	-	c.1229C>G	c.(1228-1230)TCC>TGC	p.S410C	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	410	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)										0.134328	19.930729	28.61559	9	58	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	29475178	29475178	14669	1	G	C	C	C	533	41	SFRS4	3	3
IFI44L	10964	broad.mit.edu	37	1	79101124	79101124	+	Missense_Mutation	SNP	A	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:79101124A>T	uc010oro.1	+	c.826A>T	c.(826-828)ATG>TTG	p.M276L	IFI44L_uc010orp.1_Missense_Mutation_p.M13L|IFI44L_uc010orq.1_Missense_Mutation_p.M13L	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	276						cytoplasm					0														0.063348	-24.315052	107.292498	42	621	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	79101124	79101124	7819	1	A	T	T	T	104	8	IFI44L	3	3
HCK	3055	broad.mit.edu	37	20	30662458	30662458	+	Missense_Mutation	SNP	C	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:30662458C>A	uc002wxh.2	+	c.362C>A	c.(361-363)GCC>GAC	p.A121D	HCK_uc010gdy.2_Missense_Mutation_p.A100D|HCK_uc002wxi.2_Missense_Mutation_p.A99D	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	121	SH3.				interspecies interaction between organisms|mesoderm development|protein phosphorylation|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)							262				0.070866	-4.810743	19.296237	9	118	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	30662458	30662458	7276	20	C	A	A	A	338	26	HCK	2	2
CABLES2	81928	broad.mit.edu	37	20	60966358	60966358	+	Missense_Mutation	SNP	C	G	G			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:60966358C>G	uc002ycv.2	-	c.1243G>C	c.(1243-1245)GCT>CCT	p.A415P		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	415					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)											0.227273	15.36947	16.866804	5	17	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	60966358	60966358	2646	20	C	G	G	G	338	26	CABLES2	3	3
FAM110A	83541	broad.mit.edu	37	20	826325	826325	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:826325C>T	uc002wef.1	+	c.878C>T	c.(877-879)GCT>GTT	p.A293V	FAM110A_uc002weg.1_Missense_Mutation_p.A293V|FAM110A_uc002weh.1_Missense_Mutation_p.A293V|FAM110A_uc010fzz.2_Non-coding_Transcript	NM_001042353	NP_001035812	Q9BQ89	F110A_HUMAN	hypothetical protein LOC83541	293						microtubule organizing center|spindle pole	protein binding				0														0.25	17.538049	18.901631	6	18	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	826325	826325	5593	20	C	T	T	T	364	28	FAM110A	2	2
XRCC5	7520	broad.mit.edu	37	2	216983788	216983788	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:216983788C>T	uc002vfy.2	+	c.391C>T	c.(391-393)CAT>TAT	p.H131Y	XRCC5_uc002vfz.2_Missense_Mutation_p.H17Y	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	131					double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|telomeric DNA binding			kidney(1)	1		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)										0.080247	-1.458588	27.667821	13	149	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	216983788	216983788	18039	2	C	T	T	T	325	25	XRCC5	2	2
BOK	666	broad.mit.edu	37	2	242501828	242501828	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:242501828C>T	uc002wbq.2	+	c.286C>T	c.(286-288)CTG>TTG	p.L96L		NM_032515	NP_115904	Q9UMX3	BOK_HUMAN	BCL2-related ovarian killer	96					activation of caspase activity|cell proliferation|signal transduction by p53 class mediator resulting in induction of apoptosis	mitochondrial membrane|nucleus				ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.04e-33)|all cancers(36;7.87e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.52e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.64e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0835)						246				0.307692	12.895287	13.323745	4	9	KEEP	---	---	---	---	capture		Silent	SNP	242501828	242501828	1509	2	C	T	T	T	311	24	BOK	2	2
SLC8A1	6546	broad.mit.edu	37	2	40366566	40366566	+	Missense_Mutation	SNP	G	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:40366566G>C	uc002rrx.2	-	c.2520C>G	c.(2518-2520)TTC>TTG	p.F840L	SLC8A1_uc002rry.2_Missense_Mutation_p.F835L|SLC8A1_uc002rrz.2_Missense_Mutation_p.F827L|SLC8A1_uc002rsa.2_Missense_Mutation_p.F804L|SLC8A1_uc002rsd.3_Missense_Mutation_p.F804L	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	840	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)	3					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)									0.362832	140.155699	142.021799	41	72	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	40366566	40366566	15203	2	G	C	C	C	477	37	SLC8A1	3	3
BOC	91653	broad.mit.edu	37	3	112998717	112998717	+	Silent	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:112998717G>A	uc003dzz.2	+	c.2070G>A	c.(2068-2070)GAG>GAA	p.E690E	BOC_uc003dzx.2_Silent_p.E689E|BOC_uc003dzy.2_Silent_p.E689E|BOC_uc003eab.2_Silent_p.E390E|BOC_uc003eac.2_Silent_p.E4E	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	689	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)											0.105263	4.571207	10.456649	4	34	KEEP	---	---	---	---	capture		Silent	SNP	112998717	112998717	1506	3	G	A	A	A	425	33	BOC	2	2
PLA1A	51365	broad.mit.edu	37	3	119328403	119328403	+	Missense_Mutation	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:119328403G>A	uc003ecu.2	+	c.542G>A	c.(541-543)GGC>GAC	p.G181D	PLA1A_uc003ecv.2_Missense_Mutation_p.G165D|PLA1A_uc003ecw.2_Non-coding_Transcript|PLA1A_uc011bjc.1_Missense_Mutation_p.G8D	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	181					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			ovary(1)|central_nervous_system(1)	2														0.204444	105.612895	123.862728	46	179	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	119328403	119328403	12414	3	G	A	A	A	546	42	PLA1A	2	2
IQSEC1	9922	broad.mit.edu	37	3	12977661	12977661	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:12977661C>T	uc011auw.1	-	c.855G>A	c.(853-855)TCG>TCA	p.S285S	IQSEC1_uc003bxt.2_Silent_p.S299S|IQSEC1_uc003bxu.3_Silent_p.S177S	NM_001134382	NP_001127854	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform a	299					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1														0.222222	10.892069	12.168378	4	14	KEEP	---	---	---	---	capture		Silent	SNP	12977661	12977661	8120	3	C	T	T	T	236	19	IQSEC1	1	1
COL7A1	1294	broad.mit.edu	37	3	48613128	48613128	+	Silent	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:48613128G>A	uc003ctz.2	-	c.5910C>T	c.(5908-5910)TTC>TTT	p.F1970F		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1970	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(2)	9				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)										0.333333	6.247948	6.395578	2	4	KEEP	---	---	---	---	capture		Silent	SNP	48613128	48613128	3842	3	G	A	A	A	529	41	COL7A1	2	2
TWF2	11344	broad.mit.edu	37	3	52269072	52269072	+	Missense_Mutation	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:52269072G>A	uc003ddd.2	-	c.76C>T	c.(76-78)CGG>TGG	p.R26W	TWF2_uc010hmc.2_Missense_Mutation_p.R26W	NM_007284	NP_009215	Q6IBS0	TWF2_HUMAN	twinfilin-like protein	26	ADF-H 1.					cytoskeleton|perinuclear region of cytoplasm	actin binding|ATP binding			ovary(1)|lung(1)	2				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)						83				0.125	4.409152	7.705375	3	21	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	52269072	52269072	17338	3	G	A	A	A	493	38	TWF2	1	1
GEMIN5	25929	broad.mit.edu	37	5	154270922	154270922	+	Silent	SNP	A	G	G			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:154270922A>G	uc003lvx.3	-	c.4141T>C	c.(4141-4143)TTG>CTG	p.L1381L	GEMIN5_uc011ddk.1_Silent_p.L1380L	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1381	Potential.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)											0.112583	28.381329	50.740712	17	134	KEEP	---	---	---	---	capture		Silent	SNP	154270922	154270922	6599	5	A	G	G	G	37	3	GEMIN5	4	4
JMY	133746	broad.mit.edu	37	5	78602256	78602256	+	Missense_Mutation	SNP	A	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:78602256A>C	uc003kfx.3	+	c.1940A>C	c.(1939-1941)GAA>GCA	p.E647A	JMY_uc003kfw.1_Missense_Mutation_p.E293A	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	647					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)										0.046316	-42.970941	61.320044	22	453	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	78602256	78602256	8261	5	A	C	C	C	117	9	JMY	4	4
THEMIS	387357	broad.mit.edu	37	6	128134143	128134143	+	Missense_Mutation	SNP	C	G	G			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:128134143C>G	uc011ebt.1	-	c.1643G>C	c.(1642-1644)AGC>ACC	p.S548T	THEMIS_uc010kfa.2_Missense_Mutation_p.S451T|THEMIS_uc003qbi.2_Missense_Mutation_p.S548T|THEMIS_uc010kfb.2_Missense_Mutation_p.S513T	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	548					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)	2														0.227027	122.850429	135.504364	42	143	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	128134143	128134143	16388	6	C	G	G	G	364	28	THEMIS	3	3
PRSS16	10279	broad.mit.edu	37	6	27215709	27215709	+	Missense_Mutation	SNP	G	C	C	rs114674760	by1000genomes	TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:27215709G>C	uc003nja.2	+	c.119G>C	c.(118-120)AGC>ACC	p.S40T	PRSS16_uc011dkt.1_Non-coding_Transcript|PRSS16_uc003njb.2_Missense_Mutation_p.S40T|PRSS16_uc010jqq.1_5'Flank|PRSS16_uc010jqr.1_5'Flank|PRSS16_uc003njc.1_5'Flank	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	40					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)	4						NSCLC(178;1118 2105 17078 23587 44429)								0.0625	-3.597384	18.675819	7	105	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	27215709	27215709	13066	6	G	C	C	C	442	34	PRSS16	3	3
FLNC	2318	broad.mit.edu	37	7	128480629	128480629	+	Missense_Mutation	SNP	G	A	A	rs34932223		TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:128480629G>A	uc003vnz.3	+	c.1577G>A	c.(1576-1578)CGG>CAG	p.R526Q	FLNC_uc003voa.3_Missense_Mutation_p.R526Q	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	526	Filamin 3.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)	10										892				0.125	6.948535	12.44286	5	35	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	128480629	128480629	6177	7	G	A	A	A	507	39	FLNC	1	1
CARD11	84433	broad.mit.edu	37	7	2987387	2987387	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:2987387C>T	uc003smv.2	-	c.42G>A	c.(40-42)ACG>ACA	p.T14T		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	14					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|central_nervous_system(1)	48		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)					p.T14T(MUTZ3-Tumor)	1492				0.051282	-34.521551	48.594628	20	370	KEEP	---	---	---	---	capture		Silent	SNP	2987387	2987387	2764	7	C	T	T	T	340	27	CARD11	1	1
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	G	G	rs121434568		TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr7:55259515T>G	uc003tqk.2	+	c.2573T>G	c.(2572-2574)CTG>CGG	p.L858R	EGFR_uc010kzg.1_Missense_Mutation_p.L813R|EGFR_uc011kco.1_Missense_Mutation_p.L805R	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	858	Cytoplasmic (Potential).|Protein kinase.		L -> R (found in a lung cancer sample; somatic mutation).|L -> M (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(3084)|p.L858Q(3)|p.L858A(2)|p.L858W(1)|p.L858P(1)|p.L858L(1)|p.L858K(1)|p.L858G(1)|p.H805I(1)		lung(8200)|central_nervous_system(103)|upper_aerodigestive_tract(37)|prostate(32)|ovary(31)|thyroid(23)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|stomach(6)|urinary_tract(6)|skin(5)|adrenal_gland(5)|kidney(4)|soft_tissue(4)|bone(3)|NS(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)|pancreas(1)	8515	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)		L858R(NCIH1975_LUNG)	8		608	TCGA GBM(3;<1E-8)|TSP Lung(4;<1E-8)			0.259524	302.019729	324.069612	109	311	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	55259515	55259515	5156	7	T	G	G	G	715	55	EGFR	4	4
GPR172A	79581	broad.mit.edu	37	8	145583657	145583657	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:145583657C>T	uc003zcc.1	+	c.505C>T	c.(505-507)CGC>TGC	p.R169C	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.R169C|GPR172A_uc003zce.1_Missense_Mutation_p.R169C|GPR172A_uc010mfy.1_Missense_Mutation_p.R169C|GPR172A_uc003zcf.1_Missense_Mutation_p.R169C|GPR172A_uc011llc.1_Missense_Mutation_p.R81C	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	169						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)											0.375	9.123722	9.233182	3	5	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	145583657	145583657	6944	8	C	T	T	T	299	23	GPR172A	1	1
POTEA	340441	broad.mit.edu	37	8	43197329	43197329	+	Splice_Site_SNP	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:43197329G>A	uc003xpz.1	+	c.1219_splice	c.e11-1	p.V407_splice	POTEA_uc003xqa.1_Splice_Site_SNP_p.V361_splice	NM_001005365	NP_001005365			POTE ankyrin domain family, member A isoform 2											ovary(1)	1														0.254826	201.73313	215.852596	66	193	KEEP	---	---	---	---	capture		Splice_Site_SNP	SNP	43197329	43197329	12690	8	G	A	A	A	455	35	POTEA	5	2
PXDNL	137902	broad.mit.edu	37	8	52359654	52359654	+	Missense_Mutation	SNP	C	G	G			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:52359654C>G	uc003xqu.3	-	c.1435G>C	c.(1435-1437)GCA>CCA	p.A479P		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	479	Ig-like C2-type 3.				hydrogen peroxide catabolic process|oxidation-reduction process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)												0.096842	53.590352	130.940859	46	429	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	52359654	52359654	13306	8	C	G	G	G	364	28	PXDNL	3	3
OTUD6B	51633	broad.mit.edu	37	8	92090700	92090700	+	Silent	SNP	T	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr8:92090700T>C	uc003yeu.3	+	c.522T>C	c.(520-522)GCT>GCC	p.A174A	OTUD6B_uc011lgh.1_Silent_p.A43A	NM_016023	NP_057107	Q8N6M0	OTU6B_HUMAN	OTU domain containing 6B	144										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0187)											0.090909	3.900496	9.465957	3	30	KEEP	---	---	---	---	capture		Silent	SNP	92090700	92090700	11730	8	T	C	C	C	678	53	OTUD6B	4	4
DBC1	1620	broad.mit.edu	37	9	121930416	121930416	+	Missense_Mutation	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:121930416C>T	uc004bkc.2	-	c.1232G>A	c.(1231-1233)CGG>CAG	p.R411Q		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	411					cell cycle arrest|cell death	cytoplasm	protein binding			ovary(2)|central_nervous_system(2)|large_intestine(1)	5														0.45	28.97255	29.016071	9	11	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	121930416	121930416	4418	9	C	T	T	T	299	23	DBC1	1	1
TOR1A	1861	broad.mit.edu	37	9	132585013	132585013	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:132585013C>T	uc004byl.2	-	c.291G>A	c.(289-291)ACG>ACA	p.T97T	TOR1A_uc004bym.2_Non-coding_Transcript|TOR1A_uc004byn.2_Silent_p.T97T	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	97					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)												0.072289	-0.011869	15.610687	6	77	KEEP	---	---	---	---	capture		Silent	SNP	132585013	132585013	16913	9	C	T	T	T	340	27	TOR1A	1	1
HTATSF1	27336	broad.mit.edu	37	X	135592250	135592250	+	Missense_Mutation	SNP	G	A	A			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:135592250G>A	uc004ezw.2	+	c.934G>A	c.(934-936)GAT>AAT	p.D312N	HTATSF1_uc004ezx.2_Missense_Mutation_p.D312N	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	312	RRM 2.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding|RNA polymerase II transcription factor activity|transcription elongation regulator activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)													0.082569	12.335434	89.640968	36	400	KEEP	---	---	---	---	capture		Missense_Mutation	SNP	135592250	135592250	7733	23	G	A	A	A	429	33	HTATSF1	2	2
ERCC6L	54821	broad.mit.edu	37	X	71427306	71427306	+	Silent	SNP	C	T	T			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chrX:71427306C>T	uc004eaq.1	-	c.1311G>A	c.(1309-1311)GAG>GAA	p.E437E	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Silent_p.E314E	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	437					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)													0.048287	-61.654616	77.675665	31	611	KEEP	---	---	---	---	capture		Silent	SNP	71427306	71427306	5411	23	C	T	T	T	311	24	ERCC6L	2	2
TTN	7273	broad.mit.edu	37	2	179535845	179535845	+	Frame_Shift_Del	DEL	A	-	-			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:179535845_179535845delA	uc010zfg.1	-	c.31377_31377delT	c.(31375-31377)GTTfs	p.V10459fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.V7120fs|TTN_uc010fre.1_Intron|TTN_uc010zfk.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	746										ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)							8722				0.36			48	87		---	---	---	---	capture_indel		Frame_Shift_Del	DEL	179535845	179535845	17290	2	A	-	-	-	54	5	TTN	5	5
KIAA1486	57624	broad.mit.edu	37	2	226447378	226447379	+	Frame_Shift_Ins	INS	-	C	C			TCGA-67-3772-01	TCGA-67-3772-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:226447378_226447379insC	uc002voe.2	+	c.1245_1246insC	c.(1243-1248)CCACCCfs	p.P415fs	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Frame_Shift_Ins_p.P185fs	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	415_416	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)										0.33			2	4		---	---	---	---	capture_indel		Frame_Shift_Ins	INS	226447378	226447379	8546	2	-	C	C	C	67	6	KIAA1486	5	5
