Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
WDR8	49856	broad.mit.edu	37	1	3563878	3563878	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3563878delT	uc001ako.2	-						WDR8_uc001akn.3_Intron|WDR8_uc010nzi.1_Intron	NM_017818	NP_060288			WD repeat domain 8							centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)														---	---	---	---
PER3	8863	broad.mit.edu	37	1	7845483	7845483	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:7845483delT	uc001aoo.2	+						PER3_uc009vmg.1_Intron|PER3_uc009vmh.1_Intron|PER3_uc001aop.2_Intron|PER3_uc010nzw.1_Intron|PER3_uc001aon.2_Intron	NM_016831	NP_058515			period 3						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TNFRSF9	3604	broad.mit.edu	37	1	7980709	7980711	+	3'UTR	DEL	AAA	-	-	rs75132885		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:7980709_7980711delAAA	uc001aot.2	-	8						NM_001561	NP_001552			tumor necrosis factor receptor superfamily,						induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PLOD1	5351	broad.mit.edu	37	1	12033174	12033174	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12033174delA	uc001atm.2	+						PLOD1_uc010obb.1_Intron	NM_000302	NP_000293			lysyl hydroxylase 1 precursor						epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12464124	12464124	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12464124delT	uc001atv.2	+						VPS13D_uc001atw.2_Intron|VPS13D_uc001atx.2_Intron|VPS13D_uc009vnl.2_Intron	NM_015378	NP_056193			vacuolar protein sorting 13D isoform 1						protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)														---	---	---	---
PRAMEF5	343068	broad.mit.edu	37	1	13012832	13012832	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:13012832delA	uc001aur.2	-							NM_001013407	NP_001013425			PRAME family member 5												0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CROCC	9696	broad.mit.edu	37	1	17299013	17299014	+	3'UTR	DEL	CA	-	-	rs6661019	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17299013_17299014delCA	uc001azt.2	+	37					CROCC_uc001azu.2_3'UTR|CROCC_uc001azv.2_3'UTR	NM_014675	NP_055490			ciliary rootlet coiled-coil						cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)														---	---	---	---
KIF17	57576	broad.mit.edu	37	1	21041827	21041827	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21041827delT	uc001bdr.3	-						KIF17_uc001bds.3_Intron	NM_020816	NP_065867			kinesin family member 17 isoform a						microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)														---	---	---	---
ECE1	1889	broad.mit.edu	37	1	21553520	21553521	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21553520_21553521delTT	uc001bek.2	-						ECE1_uc001bem.2_Intron|ECE1_uc001bej.2_Intron|ECE1_uc001bei.2_Intron|ECE1_uc010odl.1_Intron	NM_001397	NP_001388			endothelin converting enzyme 1 isoform 1						bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)														---	---	---	---
EPHB2	2048	broad.mit.edu	37	1	23240246	23240246	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23240246delA	uc009vqj.1	+	17	3196	c.3051delA	c.(3049-3051)GGAfs	p.G1017fs	EPHB2_uc001bge.2_3'UTR|EPHB2_uc001bgf.2_3'UTR|EPHB2_uc010odu.1_3'UTR	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	1017	Cytoplasmic (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)										Hereditary_Prostate_Cancer				---	---	---	---
FUCA1	2517	broad.mit.edu	37	1	24175456	24175456	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24175456delT	uc001bie.2	-							NM_000147	NP_000138			fucosidase, alpha-L-1, tissue precursor						fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)														---	---	---	---
ARID1A	8289	broad.mit.edu	37	1	27087188	27087190	+	Intron	DEL	ATT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27087188_27087190delATT	uc001bmv.1	+						ARID1A_uc001bmt.1_Intron|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Intron	NM_006015	NP_006006			AT rich interactive domain 1A isoform a						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)				Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								---	---	---	---
YTHDF2	51441	broad.mit.edu	37	1	29070609	29070610	+	Intron	INS	-	G	G	rs72508792	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29070609_29070610insG	uc001brc.2	+						YTHDF2_uc001brd.2_Intron|YTHDF2_uc010ofx.1_Intron|YTHDF2_uc001bre.2_Intron	NM_016258	NP_057342			high glucose-regulated protein 8						humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
EIF3I	8668	broad.mit.edu	37	1	32691629	32691629	+	Intron	DEL	A	-	-	rs74686229		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32691629delA	uc001bur.3	+						EIF3I_uc009vuc.2_Intron|EIF3I_uc001bus.2_Intron	NM_003757	NP_003748			eukaryotic translation initiation factor 3,							cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)																---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34007076	34007076	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34007076delT	uc001bxn.1	-						CSMD2_uc001bxm.1_Intron	NM_052896	NP_443128			CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34175032	34175032	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34175032delA	uc001bxn.1	-						CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxo.1_5'UTR	NM_052896	NP_443128			CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
C1orf109	54955	broad.mit.edu	37	1	38155688	38155688	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38155688delT	uc001cbp.2	-						C1orf109_uc010oig.1_Intron|C1orf109_uc001cbo.2_Intron|C1orf109_uc001cbq.1_Intron|CDCA8_uc001cbr.2_5'Flank|CDCA8_uc001cbs.2_5'Flank|CDCA8_uc010oih.1_5'Flank	NM_017850	NP_060320			hypothetical protein LOC54955												0		Myeloproliferative disorder(586;0.0393)																---	---	---	---
SF3A3	10946	broad.mit.edu	37	1	38447614	38447615	+	Intron	INS	-	T	T	rs111640788		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38447614_38447615insT	uc001cci.2	-						SF3A3_uc010oik.1_Intron	NM_006802	NP_006793			splicing factor 3a, subunit 3						nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)																---	---	---	---
MFSD2A	84879	broad.mit.edu	37	1	40429116	40429116	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40429116delA	uc001cev.2	+						MFSD2A_uc010ojb.1_Intron|MFSD2A_uc001ceu.2_Intron|MFSD2A_uc010ojc.1_Intron|MFSD2A_uc009vvy.2_Intron	NM_001136493	NP_001129965			major facilitator superfamily domain containing						transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	40929369	40929369	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40929369delA								ZNF643 (17 upstream) : ZNF642 (13933 downstream)																																			---	---	---	---
ZCCHC11	23318	broad.mit.edu	37	1	52923972	52923972	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52923972delA	uc001ctx.2	-						ZCCHC11_uc001cty.2_Intron|ZCCHC11_uc001ctz.2_Intron|ZCCHC11_uc009vze.1_Intron|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cua.1_Intron	NM_015269	NP_056084			zinc finger, CCHC domain containing 11 isoform						miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
ZCCHC11	23318	broad.mit.edu	37	1	52937901	52937901	+	Intron	DEL	A	-	-	rs78098408		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52937901delA	uc001ctx.2	-						ZCCHC11_uc001cty.2_Intron|ZCCHC11_uc001ctz.2_Intron|ZCCHC11_uc009vze.1_Intron|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cub.2_Intron	NM_015269	NP_056084			zinc finger, CCHC domain containing 11 isoform						miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
FUBP1	8880	broad.mit.edu	37	1	78432648	78432648	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78432648delA	uc001dii.2	-						FUBP1_uc001dih.3_Intron|FUBP1_uc010orm.1_Intron	NM_003902	NP_003893			far upstream element-binding protein						transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	79132403	79132404	+	IGR	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:79132403_79132404delAA								IFI44 (2642 upstream) : ELTD1 (223047 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	81564713	81564713	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:81564713delT								None (None upstream) : LPHN2 (207132 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	84709900	84709900	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:84709900delA								PRKACB (5721 upstream) : SAMD13 (54149 downstream)																																			---	---	---	---
CLCA1	1179	broad.mit.edu	37	1	86959296	86959296	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86959296delT	uc001dlt.2	+						CLCA1_uc001dls.1_Intron	NM_001285	NP_001276			chloride channel accessory 1 precursor						calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)														---	---	---	---
EVI5	7813	broad.mit.edu	37	1	93159470	93159470	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93159470delA	uc001dox.2	-						EVI5_uc010otf.1_Intron|EVI5_uc001doy.1_Intron	NM_005665	NP_005656			ecotropic viral integration site 5						cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)														---	---	---	---
CCDC18	343099	broad.mit.edu	37	1	93721326	93721327	+	Intron	INS	-	GAAGAGGAA	GAAGAGGAA	rs138730379	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93721326_93721327insGAAGAGGAA	uc001dpq.2	+						CCDC18_uc001dpr.1_Intron	NM_206886	NP_996769			sarcoma antigen NY-SAR-41											ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	94871896	94871896	+	IGR	DEL	G	-	-	rs12091363		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94871896delG								ARHGAP29 (131272 upstream) : ABCD3 (12037 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	96914049	96914049	+	IGR	DEL	C	-	-	rs1931180	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:96914049delC								None (None upstream) : PTBP2 (273126 downstream)																																			---	---	---	---
SLC30A7	148867	broad.mit.edu	37	1	101372571	101372571	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101372571delA	uc001dtn.2	+						SLC30A7_uc001dto.2_Intron	NM_001144884	NP_001138356			zinc transporter like 2						zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)														---	---	---	---
PTPN22	26191	broad.mit.edu	37	1	114380072	114380072	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114380072delA	uc001eds.2	-						PTPN22_uc009wgq.2_Intron|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Intron|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Intron	NM_015967	NP_057051			protein tyrosine phosphatase, non-receptor type						negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
AP4B1	10717	broad.mit.edu	37	1	114442339	114442339	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114442339delA	uc001eeb.2	-						uc001edv.1_Intron|AP4B1_uc001eec.2_Intron|AP4B1_uc001eed.2_Intron|AP4B1_uc010owp.1_Intron|AP4B1_uc001eea.1_Intron|AP4B1_uc001eee.1_5'Flank|AP4B1_uc010owq.1_3'UTR	NM_006594	NP_006585			adaptor-related protein complex 4, beta 1						intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	116891725	116891726	+	IGR	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:116891725_116891726delAA								C1orf161 (213864 upstream) : ATP1A1 (23278 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	118236238	118236241	+	IGR	DEL	CTTT	-	-	rs71736170	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118236238_118236241delCTTT								FAM46C (65228 upstream) : GDAP2 (169867 downstream)																																			---	---	---	---
WDR3	10885	broad.mit.edu	37	1	118484530	118484531	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118484530_118484531insA	uc010oxe.1	+						WDR3_uc001ehi.2_Intron	NM_006784	NP_006775			WD repeat-containing protein 3							nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)														---	---	---	---
NBPF10	100132406	broad.mit.edu	37	1	145559919	145559919	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145559919delA	uc001emp.3	+						ANKRD35_uc010oyx.1_Intron|ANKRD35_uc001eob.1_Intron	NM_017940	NP_060410			hypothetical protein LOC55672												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)														---	---	---	---
NBPF10	100132406	broad.mit.edu	37	1	145645968	145645968	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145645968delA	uc001emp.3	+						RNF115_uc001eoj.2_Intron|RNF115_uc001eok.2_Intron|RNF115_uc009wiy.2_Intron	NM_017940	NP_060410			hypothetical protein LOC55672												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	148855840	148855842	+	IGR	DEL	GGT	-	-	rs60282471		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:148855840_148855842delGGT								NBPF16 (97529 upstream) : LOC645166 (72444 downstream)																																			---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	153994528	153994528	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153994528delT	uc001fdw.2	-						NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191			nucleoporin 210kDa-like isoform 1							integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
C1orf66	51093	broad.mit.edu	37	1	156702951	156702951	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156702951delT	uc001fpu.2	+						C1orf66_uc001fpv.2_Intron	NM_015997	NP_057081			hypothetical protein LOC51093 isoform 1							integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
AIM2	9447	broad.mit.edu	37	1	159038619	159038619	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159038619delA	uc001ftj.1	-							NM_004833	NP_004824			absent in melanoma 2						cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)																	---	---	---	---
CCDC19	25790	broad.mit.edu	37	1	159856131	159856133	+	Intron	DEL	AAA	-	-	rs113465282		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159856131_159856133delAAA	uc001fui.2	-						CCDC19_uc009wtb.2_Intron|CCDC19_uc001fuj.2_Intron|CCDC19_uc001fuk.2_Intron|CCDC19_uc001ful.2_Intron|CCDC19_uc009wtc.1_Intron	NM_012337	NP_036469			nasopharyngeal epithelium specific protein 1							mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)															---	---	---	---
HSPA7	3311	broad.mit.edu	37	1	161578104	161578105	+	3'UTR	INS	-	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161578104_161578105insG	uc010pkp.1	+	1						NR_024151				RecName: Full=Putative heat shock 70 kDa protein 7; AltName: Full=Heat shock 70 kDa protein B;												0																		---	---	---	---
GPR161	23432	broad.mit.edu	37	1	168056573	168056574	+	Intron	DEL	GT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:168056573_168056574delGT	uc001gfc.2	-						GPR161_uc001gfb.2_Intron|GPR161_uc010pll.1_Intron|GPR161_uc010plm.1_Intron|GPR161_uc009wvo.2_Intron|GPR161_uc001gfd.2_Intron|GPR161_uc010pln.1_Intron	NM_153832	NP_722561			G protein-coupled receptor 161 isoform 2						multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)																	---	---	---	---
RABGAP1L	9910	broad.mit.edu	37	1	174210540	174210540	+	Intron	DEL	A	-	-	rs61628461	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174210540delA	uc001gjx.2	+						RABGAP1L_uc009wwq.1_Intron|RABGAP1L_uc001gjw.2_Intron	NM_014857	NP_055672			RAB GTPase activating protein 1-like isoform A						regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
RABGAP1L	9910	broad.mit.edu	37	1	174219938	174219938	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174219938delT	uc001gjx.2	+						RABGAP1L_uc009wwq.1_Intron|RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjy.2_Intron	NM_014857	NP_055672			RAB GTPase activating protein 1-like isoform A						regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
FAM5B	57795	broad.mit.edu	37	1	177242774	177242774	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:177242774delA	uc001glf.2	+						FAM5B_uc010pna.1_Intron|FAM5B_uc001glg.2_Intron	NM_021165	NP_066988			family with sequence similarity 5, member B							extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
NPHS2	7827	broad.mit.edu	37	1	179541975	179541975	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:179541975delT	uc001gmq.3	-						NPHS2_uc009wxi.2_Intron	NM_014625	NP_055440			podocin						excretion	integral to plasma membrane	protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	182305649	182305649	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:182305649delA								ZNF648 (274802 upstream) : GLUL (46020 downstream)																																			---	---	---	---
SMG7	9887	broad.mit.edu	37	1	183519210	183519210	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183519210delA	uc001gqg.2	+						SMG7_uc001gqf.2_Intron|SMG7_uc001gqh.2_Intron|SMG7_uc001gqi.2_Intron|SMG7_uc010poc.1_Intron	NM_173156	NP_775179			SMG-7 homolog isoform 1						mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186077432	186077432	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186077432delA	uc001grq.1	+							NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
TPR	7175	broad.mit.edu	37	1	186315235	186315235	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186315235delA	uc001grv.2	-							NM_003292	NP_003283			nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
DENND1B	163486	broad.mit.edu	37	1	197643317	197643317	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197643317delA	uc001guf.3	-						DENND1B_uc010ppe.1_Intron|DENND1B_uc010ppf.1_Intron|DENND1B_uc001gue.3_Intron	NM_144977	NP_659414			DENN/MADD domain containing 1B isoform 2							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	201997682	201997682	+	IGR	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201997682delG								ELF3 (11376 upstream) : GPR37L1 (94347 downstream)																																			---	---	---	---
KDM5B	10765	broad.mit.edu	37	1	202701180	202701186	+	Intron	DEL	AAAAAAC	-	-	rs77983591	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202701180_202701186delAAAAAAC	uc001gyf.2	-						KDM5B_uc009xag.2_Intron|KDM5B_uc001gyg.1_Intron	NM_006618	NP_006609			jumonji, AT rich interactive domain 1B						negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5																		---	---	---	---
RPS6KC1	26750	broad.mit.edu	37	1	213290507	213290507	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213290507delT	uc010ptr.1	+						RPS6KC1_uc001hkd.2_Intron|RPS6KC1_uc010pts.1_Intron|RPS6KC1_uc010ptt.1_Intron|RPS6KC1_uc010ptu.1_Intron|RPS6KC1_uc010ptv.1_Intron|RPS6KC1_uc001hke.2_Intron	NM_012424	NP_036556			ribosomal protein S6 kinase, 52kDa, polypeptide						cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)														---	---	---	---
PTPN14	5784	broad.mit.edu	37	1	214706878	214706881	+	Intron	DEL	AAAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214706878_214706881delAAAA	uc001hkk.1	-						PTPN14_uc010pty.1_Intron|PTPN14_uc001hkl.1_Intron	NM_005401	NP_005392			protein tyrosine phosphatase, non-receptor type						lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)														---	---	---	---
C1orf55	163859	broad.mit.edu	37	1	226180814	226180816	+	Intron	DEL	TTC	-	-	rs66975923		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226180814_226180816delTTC	uc001hpu.3	-						C1orf55_uc001hpv.2_Intron	NM_152608	NP_689821			hypothetical protein LOC163859											lung(1)	1	Breast(184;0.197)																	---	---	---	---
LYST	1130	broad.mit.edu	37	1	235894534	235894534	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235894534delA	uc001hxj.2	-						LYST_uc001hxi.2_Intron	NM_000081	NP_000072			lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
CHRM3	1131	broad.mit.edu	37	1	239567589	239567589	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:239567589delA	uc001hyo.1	+											Homo sapiens clone N10 NTera2D1 teratocarcinoma, m3 muscarinic acetylcholine receptor mRNA, partial cds.						cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)													---	---	---	---
CHRM3	1131	broad.mit.edu	37	1	240072444	240072444	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240072444delA	uc001hyp.2	+	5	2472	c.1693delA	c.(1693-1695)AAAfs	p.K565fs		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	565	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)													---	---	---	---
AHCTF1	25909	broad.mit.edu	37	1	247005884	247005884	+	Intron	DEL	A	-	-	rs71638371		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247005884delA	uc001ibu.1	-						AHCTF1_uc001ibv.1_Intron|AHCTF1_uc009xgs.1_Intron	NM_015446	NP_056261			transcription factor ELYS						cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)															---	---	---	---
GRHL1	29841	broad.mit.edu	37	2	10101687	10101687	+	Intron	DEL	T	-	-	rs138724700		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10101687delT	uc002raa.2	+						GRHL1_uc002rab.2_Intron|GRHL1_uc002rad.2_Intron|GRHL1_uc010yjb.1_Intron	NM_198182	NP_937825			grainyhead-like 1						cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)														---	---	---	---
SMC6	79677	broad.mit.edu	37	2	17907553	17907553	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:17907553delA	uc002rco.2	-						SMC6_uc010exo.2_Intron|SMC6_uc002rcn.2_Intron|SMC6_uc002rcp.1_Intron|SMC6_uc002rcq.2_Intron|SMC6_uc002rcr.1_Intron	NM_001142286	NP_001135758			SMC6 protein						DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)																	---	---	---	---
WDR35	57539	broad.mit.edu	37	2	20174176	20174178	+	Intron	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20174176_20174178delAAA	uc002rdi.2	-						WDR35_uc002rdj.2_Intron|WDR35_uc010ext.2_Intron|WDR35_uc002rdh.2_Intron	NM_001006657	NP_001006658			WD repeat domain 35 isoform 1											ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ATAD2B	54454	broad.mit.edu	37	2	24103433	24103433	+	Intron	DEL	A	-	-	rs75314008		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24103433delA	uc002rek.3	-						ATAD2B_uc010yki.1_Intron|ATAD2B_uc010exx.1_Intron	NM_017552	NP_060022			ATPase family, AAA domain containing 2B								ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
GTF3C2	2976	broad.mit.edu	37	2	27556385	27556385	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27556385delT	uc002rjv.1	-						GTF3C2_uc010eyy.1_Intron|GTF3C2_uc002rju.1_Intron|GTF3C2_uc002rjw.1_Intron|uc002rjy.1_5'Flank	NM_001521	NP_001512			general transcription factor IIIC, polypeptide							transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
PPM1G	5496	broad.mit.edu	37	2	27605696	27605697	+	Intron	INS	-	T	T	rs111310967		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27605696_27605697insT	uc002rkl.2	-						ZNF513_uc002rkj.2_5'Flank|ZNF513_uc002rkk.2_5'Flank|PPM1G_uc002rkm.2_Intron	NM_002707	NP_002698			protein phosphatase 1G						cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
YIPF4	84272	broad.mit.edu	37	2	32517177	32517177	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32517177delT	uc002rok.2	+							NM_032312	NP_115688			Yip1 domain family, member 4							endoplasmic reticulum|integral to membrane	protein binding				0	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32690110	32690111	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32690110_32690111delTT	uc010ezu.2	+							NM_016252	NP_057336			baculoviral IAP repeat-containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
USP34	9736	broad.mit.edu	37	2	61486690	61486690	+	Intron	DEL	T	-	-	rs34649680		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61486690delT	uc002sbe.2	-						USP34_uc002sbf.2_Intron	NM_014709	NP_055524			ubiquitin specific protease 34						positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)															---	---	---	---
C2orf42	54980	broad.mit.edu	37	2	70409239	70409240	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:70409239_70409240delTT	uc002sgh.2	-							NM_017880	NP_060350			hypothetical protein LOC54980												0																		---	---	---	---
CCT7	10574	broad.mit.edu	37	2	73476357	73476357	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73476357delT	uc002siz.2	+						CCT7_uc002sja.2_Intron|CCT7_uc010yrf.1_Intron|CCT7_uc010feu.2_Intron|CCT7_uc010yrg.1_Intron|CCT7_uc010yrh.1_Intron|CCT7_uc010yri.1_Intron	NM_006429	NP_006420			chaperonin containing TCP1, subunit 7 isoform a						'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0																		---	---	---	---
CTNNA2	1496	broad.mit.edu	37	2	80646508	80646508	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:80646508delA	uc010ysh.1	+						CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysi.1_Intron	NM_004389	NP_004380			catenin, alpha 2 isoform 1						axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	101207094	101207094	+	IGR	DEL	A	-	-	rs55675417		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101207094delA								PDCL3 (13893 upstream) : NPAS2 (229519 downstream)																																			---	---	---	---
RGPD4	285190	broad.mit.edu	37	2	108487034	108487035	+	Intron	INS	-	ATC	ATC			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:108487034_108487035insATC	uc010ywk.1	+						RGPD4_uc002tdu.2_Intron|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394			RANBP2-like and GRIP domain containing 4						intracellular transport		binding			skin(2)	2																		---	---	---	---
ACOXL	55289	broad.mit.edu	37	2	111599067	111599067	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:111599067delT	uc002tgr.3	+						ACOXL_uc010fkc.2_Intron|ACOXL_uc010yxk.1_Intron	NM_001105516	NP_001098986			acyl-Coenzyme A oxidase-like 2						fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0																		---	---	---	---
RGPD5	84220	broad.mit.edu	37	2	113157160	113157160	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113157160delT	uc002ths.1	-						RGPD8_uc010fkk.1_Intron|RGPD5_uc002tht.1_Intron|RGPD5_uc010yxm.1_Intron	NM_005054	NP_005045			RANBP2-like and GRIP domain containing 5 isoform						intracellular transport	cytoplasm	binding				0																		---	---	---	---
CKAP2L	150468	broad.mit.edu	37	2	113513316	113513316	+	Intron	DEL	A	-	-	rs150191453		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113513316delA	uc002tie.2	-						CKAP2L_uc002tif.2_Intron|CKAP2L_uc010yxp.1_Intron|CKAP2L_uc010yxq.1_Intron	NM_152515	NP_689728			cytoskeleton associated protein 2-like							centrosome					0																		---	---	---	---
IWS1	55677	broad.mit.edu	37	2	128249369	128249369	+	Intron	DEL	T	-	-	rs334153	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128249369delT	uc002ton.2	-							NM_017969	NP_060439			IWS1 homolog						transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)														---	---	---	---
UGGT1	56886	broad.mit.edu	37	2	128880640	128880640	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128880640delT	uc002tps.2	+						UGGT1_uc010fme.1_Intron|UGGT1_uc002tpr.2_Intron	NM_020120	NP_064505			UDP-glucose ceramide glucosyltransferase-like 1						'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1																		---	---	---	---
ARHGAP15	55843	broad.mit.edu	37	2	144381556	144381556	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:144381556delA	uc002tvm.3	+						ARHGAP15_uc002tvn.2_Intron	NM_018460	NP_060930			ARHGAP15						regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)														---	---	---	---
GTDC1	79712	broad.mit.edu	37	2	144903038	144903038	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:144903038delA	uc002tvp.2	-						GTDC1_uc002tvo.2_Intron|GTDC1_uc002tvq.2_Intron|GTDC1_uc002tvr.2_Intron|GTDC1_uc010fnn.2_Intron|GTDC1_uc002tvs.2_Intron|GTDC1_uc010fno.2_Intron|GTDC1_uc002tvt.1_Intron	NM_001006636	NP_001006637			glycosyltransferase-like domain containing 1						biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152417500	152417500	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152417500delA	uc010fnx.2	-						NEB_uc002txr.2_Intron	NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
BAZ2B	29994	broad.mit.edu	37	2	160204996	160204996	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160204996delA	uc002uao.2	-						BAZ2B_uc002uap.2_Intron	NM_013450	NP_038478			bromodomain adjacent to zinc finger domain, 2B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4																		---	---	---	---
BAZ2B	29994	broad.mit.edu	37	2	160284756	160284756	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160284756delT	uc002uao.2	-						BAZ2B_uc002uap.2_Intron|BAZ2B_uc002uaq.1_Intron|BAZ2B_uc002uar.1_Intron	NM_013450	NP_038478			bromodomain adjacent to zinc finger domain, 2B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4																		---	---	---	---
SCN3A	6328	broad.mit.edu	37	2	165996281	165996281	+	Intron	DEL	A	-	-	rs2289400	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165996281delA	uc002ucx.2	-						SCN3A_uc002ucy.2_Intron|SCN3A_uc002ucz.2_Intron|SCN3A_uc002uda.1_Intron|SCN3A_uc002udb.1_Intron	NM_006922	NP_008853			sodium channel, voltage-gated, type III, alpha							voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)													---	---	---	---
SPC25	57405	broad.mit.edu	37	2	169745701	169745701	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169745701delA	uc002uel.2	-							NM_020675	NP_065726			spindle pole body component 25						cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)	1																		---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170033201	170033201	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170033201delA	uc002ues.2	-							NM_004525	NP_004516			low density lipoprotein-related protein 2						hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
RAPGEF4	11069	broad.mit.edu	37	2	173662239	173662239	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173662239delT	uc002uhv.3	+						RAPGEF4_uc002uhu.2_Intron|RAPGEF4_uc010fqn.2_Intron	NM_007023	NP_008954			Rap guanine nucleotide exchange factor (GEF) 4						blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)															---	---	---	---
ZAK	51776	broad.mit.edu	37	2	174123373	174123373	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:174123373delA	uc002uhz.2	+						uc002uib.2_Intron	NM_016653	NP_057737			MLK-related kinase isoform 1						activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)															---	---	---	---
TTC30B	150737	broad.mit.edu	37	2	178415367	178415367	+	3'UTR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178415367delT	uc002uln.2	-	1					TTC30B_uc010zfc.1_3'UTR	NM_152517	NP_689730			tetratricopeptide repeat domain 30B						cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)															---	---	---	---
ITGA4	3676	broad.mit.edu	37	2	182344708	182344708	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182344708delT	uc002unu.2	+						ITGA4_uc010zfl.1_Intron	NM_000885	NP_000876			integrin alpha 4 precursor						blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)													---	---	---	---
FAM171B	165215	broad.mit.edu	37	2	187608158	187608158	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:187608158delT	uc002ups.2	+						FAM171B_uc002upr.1_Intron	NM_177454	NP_803237			KIAA1946							integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10																		---	---	---	---
CALCRL	10203	broad.mit.edu	37	2	188224010	188224010	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:188224010delA	uc002upv.3	-						CALCRL_uc010frt.2_Intron	NM_005795	NP_005786			calcitonin receptor-like precursor							integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)															---	---	---	---
STAT1	6772	broad.mit.edu	37	2	191857520	191857521	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191857520_191857521delTT	uc002usj.2	-						STAT1_uc010fse.1_Intron|STAT1_uc002usk.2_Intron|STAT1_uc002usl.2_Intron|STAT1_uc010fsf.1_Intron	NM_007315	NP_009330			signal transducer and activator of transcription						activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)													---	---	---	---
TMEFF2	23671	broad.mit.edu	37	2	193056769	193056769	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:193056769delA	uc002utc.2	-						TMEFF2_uc002utd.1_Intron	NM_016192	NP_057276			transmembrane protein with EGF-like and two							extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)															---	---	---	---
HSPD1	3329	broad.mit.edu	37	2	198360203	198360203	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198360203delA	uc002uui.2	-						HSPD1_uc002uuj.2_Intron|HSPD1_uc010zgx.1_Intron|HSPD1_uc010fsm.2_5'UTR|HSPD1_uc002uuk.2_Intron	NM_002156	NP_002147			chaperonin						'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)															---	---	---	---
CYP20A1	57404	broad.mit.edu	37	2	204110555	204110555	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204110555delT	uc002uzv.3	+						CYP20A1_uc002uzx.3_Intron|CYP20A1_uc010zif.1_Intron|CYP20A1_uc002uzy.3_Intron|CYP20A1_uc002uzw.3_Intron	NM_177538	NP_803882			cytochrome P450, family 20, subfamily A,							integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0																		---	---	---	---
COL4A3	1285	broad.mit.edu	37	2	228148821	228148821	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228148821delT	uc002vom.1	+						COL4A3_uc002von.1_Intron|COL4A3_uc002voo.1_Intron|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082			alpha 3 type IV collagen isoform 1 precursor						activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	231033634	231033635	+	IGR	INS	-	TAA	TAA	rs33940219		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231033634_231033635insTAA								FBXO36 (85618 upstream) : SP110 (10 downstream)																																			---	---	---	---
RBM44	375316	broad.mit.edu	37	2	238729963	238729963	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238729963delT	uc002vxi.3	+							NM_001080504	NP_001073973			RNA binding motif protein 44								nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)														---	---	---	---
KIF1A	547	broad.mit.edu	37	2	241724234	241724234	+	Intron	DEL	G	-	-	rs113212728		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241724234delG	uc002vzy.2	-						KIF1A_uc010fzk.2_Intron|KIF1A_uc002vzz.1_Intron	NM_004321	NP_004312			axonal transport of synaptic vesicles						anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)														---	---	---	---
ATG4B	23192	broad.mit.edu	37	2	242590653	242590653	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242590653delT	uc002wbv.2	+						ATG4B_uc002wbu.2_Intron|ATG4B_uc002wbw.2_Intron|ATG4B_uc010zox.1_Intron|ATG4B_uc010zoy.1_Intron|ATG4B_uc010fzp.2_Intron|ATG4B_uc010zoz.1_5'Flank	NM_013325	NP_037457			APG4 autophagy 4 homolog B isoform a						autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)														---	---	---	---
FANCD2	2177	broad.mit.edu	37	3	10081677	10081678	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10081677_10081678delAA	uc003buw.2	+						FANCD2_uc003bux.1_Intron|FANCD2_uc003buy.1_Intron|FANCD2_uc003buv.2_3'UTR	NM_033084	NP_149075			Fanconi anemia complementation group D2 isoform						DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)				D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
VGLL4	9686	broad.mit.edu	37	3	11599950	11599950	+	3'UTR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:11599950delT	uc003bwf.2	-	6					VGLL4_uc010hdx.1_3'UTR|VGLL4_uc003bwg.2_3'UTR|VGLL4_uc010hdv.1_3'UTR|VGLL4_uc010hdw.1_3'UTR|VGLL4_uc011aun.1_3'UTR	NM_014667	NP_055482			vestigial like 4 isoform b						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)														---	---	---	---
IQSEC1	9922	broad.mit.edu	37	3	12944144	12944144	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12944144delA	uc003bxt.2	-						IQSEC1_uc003bxu.3_Intron|IQSEC1_uc011auw.1_Intron	NM_014869	NP_055684			IQ motif and Sec7 domain 1 isoform b						regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
IQSEC1	9922	broad.mit.edu	37	3	12944170	12944180	+	Intron	DEL	CAAAAAAAAAA	-	-	rs6791577		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12944170_12944180delCAAAAAAAAAA	uc003bxt.2	-						IQSEC1_uc003bxu.3_Intron|IQSEC1_uc011auw.1_Intron	NM_014869	NP_055684			IQ motif and Sec7 domain 1 isoform b						regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
RARB	5915	broad.mit.edu	37	3	25635836	25635836	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:25635836delT	uc011awl.1	+						RARB_uc003cdi.1_Intron|RARB_uc003cdh.2_Intron	NM_016152	NP_057236			retinoic acid receptor, beta isoform 2						embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)													---	---	---	---
PDCD6IP	10015	broad.mit.edu	37	3	33868211	33868212	+	Intron	DEL	TT	-	-	rs35254856		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33868211_33868212delTT	uc003cfx.2	+						PDCD6IP_uc011axv.1_3'UTR|PDCD6IP_uc003cfy.2_Intron|PDCD6IP_uc011axw.1_5'Flank	NM_013374	NP_037506			programmed cell death 6 interacting protein						apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2																		---	---	---	---
LRRFIP2	9209	broad.mit.edu	37	3	37163411	37163411	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37163411delT	uc003cgp.2	-						LRRFIP2_uc011ayf.1_Intron|LRRFIP2_uc003cgr.2_Intron|LRRFIP2_uc003cgs.3_Intron|LRRFIP2_uc003cgt.3_Intron	NM_006309	NP_006300			leucine rich repeat (in FLII) interacting						Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1																		---	---	---	---
ZNF197	10168	broad.mit.edu	37	3	44672900	44672901	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44672900_44672901delTT	uc003cnm.2	+						ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922			zinc finger protein 197 isoform 1						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)														---	---	---	---
KIF15	56992	broad.mit.edu	37	3	44868019	44868019	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44868019delT	uc003cnx.3	+						KIF15_uc010hiq.2_Intron|KIF15_uc010hir.2_Intron	NM_020242	NP_064627			kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)														---	---	---	---
LRRC2	79442	broad.mit.edu	37	3	46560368	46560368	+	3'UTR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46560368delT	uc010hji.2	-	9					LRRC2_uc003cpu.3_3'UTR	NM_024512	NP_078788			leucine rich repeat containing 2											ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)														---	---	---	---
SETD2	29072	broad.mit.edu	37	3	47129455	47129458	+	Intron	DEL	AAAC	-	-	rs66851205		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47129455_47129458delAAAC	uc003cqs.2	-						SETD2_uc003cqv.2_Intron	NM_014159	NP_054878			SET domain containing 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)				N|F|S|Mis		clear cell renal carcinoma								---	---	---	---
PRKAR2A	5576	broad.mit.edu	37	3	48794052	48794052	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48794052delA	uc010hki.1	-						PRKAR2A_uc003cux.1_Intron|PRKAR2A_uc003cuy.1_Intron	NM_004157	NP_004148			cAMP-dependent protein kinase, regulatory						activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)														---	---	---	---
POC1A	25886	broad.mit.edu	37	3	52181250	52181251	+	Intron	DEL	TT	-	-	rs78047346		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52181250_52181251delTT	uc003dcu.2	-						POC1A_uc003dcv.2_Intron|POC1A_uc003dcw.2_Intron	NM_015426	NP_056241			WD repeat domain 51A isoform 1							centriole|microtubule basal body					0																		---	---	---	---
GLT8D1	55830	broad.mit.edu	37	3	52731588	52731588	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52731588delA	uc003dfi.3	-						GLT8D1_uc003dfj.2_Intron|GLT8D1_uc003dfk.2_Intron|GLT8D1_uc003dfl.2_Intron|GLT8D1_uc003dfm.2_Intron|GLT8D1_uc003dfn.2_Intron|GLT8D1_uc003dfo.1_Intron	NM_152932	NP_690909			glycosyltransferase 8 domain containing 1							integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups				0				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)														---	---	---	---
IL17RB	55540	broad.mit.edu	37	3	53898562	53898563	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53898562_53898563insA	uc003dha.2	+							NM_018725	NP_061195			interleukin 17B receptor precursor						defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)														---	---	---	---
SLMAP	7871	broad.mit.edu	37	3	57850103	57850103	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57850103delA	uc003dje.1	+						SLMAP_uc003djc.1_Intron|SLMAP_uc003djd.1_Intron|SLMAP_uc003djf.1_Intron|SLMAP_uc003djg.1_5'Flank	NM_007159	NP_009090			sarcolemma associated protein						muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)														---	---	---	---
SLMAP	7871	broad.mit.edu	37	3	57882416	57882416	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57882416delA	uc003dje.1	+						SLMAP_uc003djc.1_Intron|SLMAP_uc003djd.1_Intron|SLMAP_uc003djf.1_Intron|SLMAP_uc003djg.1_Intron|SLMAP_uc011bez.1_Intron|SLMAP_uc011bfa.1_Intron|SLMAP_uc003djh.2_Intron|SLMAP_uc003dji.1_Intron|SLMAP_uc011bfb.1_Intron|SLMAP_uc011bfc.1_Intron	NM_007159	NP_009090			sarcolemma associated protein						muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)														---	---	---	---
FLNB	2317	broad.mit.edu	37	3	58109902	58109902	+	Intron	DEL	G	-	-	rs112600741		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58109902delG	uc003djj.2	+						FLNB_uc010hne.2_Intron|FLNB_uc003djk.2_Intron|FLNB_uc010hnf.2_Intron|FLNB_uc003djl.2_Intron|FLNB_uc003djm.2_Intron	NM_001457	NP_001448			filamin B isoform 2						actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)														---	---	---	---
C3orf64	285203	broad.mit.edu	37	3	69059085	69059086	+	Intron	DEL	AA	-	-	rs6549171		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:69059085_69059086delAA	uc003dnl.2	-						C3orf64_uc003dnk.2_Intron|C3orf64_uc011bfw.1_Intron|C3orf64_uc003dnm.1_Intron	NM_173654	NP_775925			AER61 glycosyltransferase							extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)														---	---	---	---
FOXP1	27086	broad.mit.edu	37	3	71090807	71090807	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:71090807delT	uc003dol.2	-						FOXP1_uc003dom.2_Intron|FOXP1_uc003don.2_Intron|FOXP1_uc003doo.2_Intron|FOXP1_uc003dop.2_Intron|FOXP1_uc003doq.1_Intron|FOXP1_uc003doi.2_Intron|FOXP1_uc003doj.2_Intron|FOXP1_uc003dok.2_Intron|FOXP1_uc003dor.1_5'Flank	NM_032682	NP_116071			forkhead box P1 isoform 1						cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)				T	PAX5	ALL								---	---	---	---
EPHA3	2042	broad.mit.edu	37	3	89156756	89156758	+	5'UTR	DEL	CTC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:89156756_89156758delCTC	uc003dqy.2	+	1					EPHA3_uc003dqx.1_5'UTR|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224			ephrin receptor EphA3 isoform a precursor							extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)											TSP Lung(6;0.00050)			---	---	---	---
DCBLD2	131566	broad.mit.edu	37	3	98529907	98529907	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:98529907delT	uc003dtd.2	-						DCBLD2_uc003dte.2_Intron	NM_080927	NP_563615			discoidin, CUB and LCCL domain containing 2						cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3																		---	---	---	---
TBC1D23	55773	broad.mit.edu	37	3	100020784	100020784	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100020784delT	uc003dtt.2	+						TBC1D23_uc003dts.2_Intron	NM_018309	NP_060779			TBC1 domain family, member 23							intracellular	Rab GTPase activator activity			ovary(1)|liver(1)	2																		---	---	---	---
TBC1D23	55773	broad.mit.edu	37	3	100042414	100042414	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100042414delT	uc003dtt.2	+						TBC1D23_uc003dts.2_Intron|TBC1D23_uc003dtu.2_Intron	NM_018309	NP_060779			TBC1 domain family, member 23							intracellular	Rab GTPase activator activity			ovary(1)|liver(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	101318024	101318025	+	IGR	DEL	TT	-	-	rs148687228	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101318024_101318025delTT								PCNP (4745 upstream) : ZBTB11 (50260 downstream)																																			---	---	---	---
CEP97	79598	broad.mit.edu	37	3	101445761	101445761	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101445761delA	uc003dvk.1	+						CEP97_uc010hpm.1_Intron|CEP97_uc011bhf.1_Intron|CEP97_uc003dvl.1_5'Flank	NM_024548	NP_078824			centrosomal protein 97kDa							centrosome|nucleus	protein binding			ovary(2)	2																		---	---	---	---
MYH15	22989	broad.mit.edu	37	3	108173172	108173172	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108173172delA	uc003dxa.1	-							NM_014981	NP_055796			myosin, heavy polypeptide 15							myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7																		---	---	---	---
PHLDB2	90102	broad.mit.edu	37	3	111671328	111671328	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111671328delT	uc010hqa.2	+						PHLDB2_uc003dyc.2_Intron|PHLDB2_uc003dyd.2_Intron|PHLDB2_uc003dyg.2_Intron|PHLDB2_uc003dyh.2_Intron|PHLDB2_uc003dyi.2_Intron	NM_001134438	NP_001127910			pleckstrin homology-like domain, family B,							cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6																		---	---	---	---
C3orf17	25871	broad.mit.edu	37	3	112736520	112736520	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112736520delA	uc003dzr.2	-						C3orf17_uc011bhz.1_Intron|C3orf17_uc010hqh.2_Intron|C3orf17_uc003dzt.2_Intron|C3orf17_uc003dzs.2_Intron|C3orf17_uc010hqg.2_Intron|C3orf17_uc011bia.1_Intron|C3orf17_uc003dzu.2_Intron|C3orf17_uc011bib.1_Intron|C3orf17_uc011bic.1_Intron|C3orf17_uc011bid.1_Intron	NM_015412	NP_056227			hypothetical protein LOC25871							integral to membrane					0																		---	---	---	---
GAP43	2596	broad.mit.edu	37	3	115342811	115342811	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:115342811delT	uc003ebq.2	+						GAP43_uc003ebr.2_Intron	NM_002045	NP_002036			growth associated protein 43 isoform 2						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)														---	---	---	---
GTF2E1	2960	broad.mit.edu	37	3	120469352	120469353	+	Intron	INS	-	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:120469352_120469353insT	uc003edz.3	+						GTF2E1_uc003edy.2_Intron	NM_005513	NP_005504			general transcription factor IIE, polypeptide 1,						interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)														---	---	---	---
ILDR1	286676	broad.mit.edu	37	3	121720828	121720828	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121720828delA	uc003ees.2	-						ILDR1_uc003eeq.2_Intron|ILDR1_uc003eer.2_Intron|ILDR1_uc010hrg.2_Intron	NM_175924	NP_787120			immunoglobulin-like domain containing receptor							cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)														---	---	---	---
CD86	942	broad.mit.edu	37	3	121825017	121825017	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121825017delT	uc003eet.2	+						CD86_uc011bjo.1_Intron|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Intron	NM_175862	NP_787058			CD86 antigen isoform 1						interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)													---	---	---	---
CCDC58	131076	broad.mit.edu	37	3	122081882	122081882	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122081882delA	uc003eey.2	-							NM_001017928	NP_001017928			coiled-coil domain containing 58												0				GBM - Glioblastoma multiforme(114;0.148)														---	---	---	---
PARP14	54625	broad.mit.edu	37	3	122414253	122414253	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122414253delT	uc003efq.3	+						PARP14_uc010hrk.2_5'Flank	NM_017554	NP_060024			poly (ADP-ribose) polymerase family, member 14						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)														---	---	---	---
H1FX	8971	broad.mit.edu	37	3	129034633	129034635	+	In_Frame_Del	DEL	TTC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129034633_129034635delTTC	uc003elx.2	-	1	486_488	c.111_113delGAA	c.(109-114)AAGAAT>AAT	p.K37del	C3orf47_uc011bkv.1_5'Flank	NM_006026	NP_006017	Q92522	H1X_HUMAN	H1 histone family, member X	37					nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133337435	133337435	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133337435delT	uc003eps.2	-						TOPBP1_uc003ept.1_Intron	NM_007027	NP_008958			topoisomerase (DNA) II binding protein 1						DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133342879	133342879	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133342879delA	uc003eps.2	-						TOPBP1_uc003ept.1_Intron	NM_007027	NP_008958			topoisomerase (DNA) II binding protein 1						DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
CLSTN2	64084	broad.mit.edu	37	3	140251458	140251458	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:140251458delT	uc003etn.2	+						CLSTN2_uc003etm.2_Intron	NM_022131	NP_071414			calsyntenin 2 precursor						homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7															HNSCC(16;0.037)			---	---	---	---
TFDP2	7029	broad.mit.edu	37	3	141710884	141710885	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141710884_141710885delAA	uc003eun.3	-						TFDP2_uc003euk.3_Intron|TFDP2_uc010hur.2_Intron|TFDP2_uc003eul.3_Intron|TFDP2_uc011bnf.1_Intron|TFDP2_uc011bng.1_Intron|TFDP2_uc003eum.3_Intron	NM_006286	NP_006277			transcription factor Dp-2 (E2F dimerization						cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)	1																		---	---	---	---
RNF13	11342	broad.mit.edu	37	3	149613537	149613537	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:149613537delT	uc003exn.3	+						RNF13_uc003exp.3_Intron|RNF13_uc010hvh.2_Intron	NM_007282	NP_009213			ring finger protein 13						protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
SGEF	26084	broad.mit.edu	37	3	153905449	153905449	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:153905449delT	uc011bog.1	+						SGEF_uc011boh.1_Intron	NM_015595	NP_056410			Src homology 3 domain-containing guanine						regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
DHX36	170506	broad.mit.edu	37	3	154010602	154010602	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154010602delT	uc003ezy.3	-						DHX36_uc010hvq.2_Intron|DHX36_uc003ezz.3_Intron	NM_020865	NP_065916			DEAH (Asp-Glu-Ala-His) box polypeptide 36							cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
MME	4311	broad.mit.edu	37	3	154834153	154834153	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154834153delT	uc010hvr.1	+						MME_uc003fab.1_Intron|MME_uc003fac.1_Intron|MME_uc003fad.1_Intron|MME_uc003fae.1_Intron	NM_007289	NP_009220			membrane metallo-endopeptidase						cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)													---	---	---	---
C3orf33	285315	broad.mit.edu	37	3	155493410	155493410	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155493410delT	uc003fal.1	-						C3orf33_uc003fam.1_Intron	NM_173657	NP_775928			hypothetical protein LOC285315								hydrolase activity, acting on ester bonds|nucleic acid binding				0			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
GFM1	85476	broad.mit.edu	37	3	158402144	158402144	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158402144delA	uc003fce.2	+						GFM1_uc003fcf.2_Intron|GFM1_uc003fcg.2_Intron	NM_024996	NP_079272			G elongation factor, mitochondrial 1 precursor						mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)															---	---	---	---
SMC4	10051	broad.mit.edu	37	3	160141139	160141147	+	Intron	DEL	TTTTTTTTG	-	-	rs4679884		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:160141139_160141147delTTTTTTTTG	uc003fdh.2	+						IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Intron|SMC4_uc003fdi.2_Intron|SMC4_uc003fdj.2_Intron|SMC4_uc010hwd.2_Intron|SMC4_uc003fdl.2_Intron	NM_001002800	NP_001002800			SMC4 structural maintenance of chromosomes						cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	166011867	166011867	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:166011867delA								BCHE (456614 upstream) : ZBBX (946214 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	3	166579565	166579566	+	IGR	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:166579565_166579566delTT								None (None upstream) : ZBBX (378515 downstream)																																			---	---	---	---
PDCD10	11235	broad.mit.edu	37	3	167402273	167402273	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167402273delA	uc003fex.2	-						PDCD10_uc003fez.2_Intron|PDCD10_uc003fey.2_Intron	NM_007217	NP_009148			programmed cell death 10						angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			lung(1)|central_nervous_system(1)	2														Familial_Cerebral_Cavernous_Angioma				---	---	---	---
TNIK	23043	broad.mit.edu	37	3	170819514	170819514	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170819514delA	uc003fhh.2	-						TNIK_uc003fhi.2_Intron|TNIK_uc003fhj.2_Intron|TNIK_uc003fhk.2_Intron|TNIK_uc003fhl.2_Intron|TNIK_uc003fhm.2_Intron|TNIK_uc003fhn.2_Intron|TNIK_uc003fho.2_Intron|TNIK_uc003fhg.2_5'UTR	NM_015028	NP_055843			TRAF2 and NCK interacting kinase isoform 1						actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)															---	---	---	---
TBL1XR1	79718	broad.mit.edu	37	3	176744032	176744032	+	Intron	DEL	A	-	-	rs112275760		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:176744032delA	uc003fiw.3	-						TBL1XR1_uc003fix.3_Intron|TBL1XR1_uc011bpz.1_Intron	NM_024665	NP_078941			transducin (beta)-like 1 X-linked receptor 1						canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)															---	---	---	---
DGKG	1608	broad.mit.edu	37	3	185867774	185867775	+	3'UTR	DEL	TG	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185867774_185867775delTG	uc003fqa.2	-	25					DGKG_uc003fqb.2_3'UTR|DGKG_uc003fqc.2_3'UTR|DGKG_uc011brx.1_3'UTR	NM_001346	NP_001337			diacylglycerol kinase gamma isoform 1						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)													---	---	---	---
TBCCD1	55171	broad.mit.edu	37	3	186268857	186268857	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:186268857delT	uc003fqg.2	-						TBCCD1_uc011bry.1_Intron|TBCCD1_uc003fqh.2_Intron	NM_018138	NP_060608			TBCC domain containing 1						cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			large_intestine(1)|ovary(1)	2	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)														---	---	---	---
FETUB	26998	broad.mit.edu	37	3	186362544	186362544	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:186362544delA	uc010hyq.2	+	5	690	c.429delA	c.(427-429)TCAfs	p.S143fs	FETUB_uc011brz.1_5'UTR|FETUB_uc003fqn.2_Frame_Shift_Del_p.S143fs|FETUB_uc003fqo.2_Frame_Shift_Del_p.S38fs|FETUB_uc010hyr.2_Frame_Shift_Del_p.S106fs|FETUB_uc010hys.2_5'UTR|FETUB_uc003fqp.3_Frame_Shift_Del_p.S78fs	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	143						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)														---	---	---	---
TP63	8626	broad.mit.edu	37	3	189525997	189525997	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:189525997delT	uc003fry.2	+						TP63_uc003frx.2_Intron|TP63_uc003frz.2_Intron|TP63_uc010hzc.1_Intron|TP63_uc003fsa.2_Intron|TP63_uc003fsb.2_Intron|TP63_uc003fsc.2_Intron|TP63_uc003fsd.2_Intron|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_5'Flank	NM_003722	NP_003713			tumor protein p63 isoform 1						anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)										Hay-Wells_syndrome	HNSCC(45;0.13)			---	---	---	---
TMEM207	131920	broad.mit.edu	37	3	190147704	190147705	+	Intron	DEL	AA	-	-	rs67899321		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:190147704_190147705delAA	uc003fsj.2	-							NM_207316	NP_997199			transmembrane protein 207 precursor							integral to membrane					0	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)														---	---	---	---
FGF12	2257	broad.mit.edu	37	3	192078485	192078485	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:192078485delT	uc003fsx.2	-						FGF12_uc003fsy.2_Intron	NM_021032	NP_066360			fibroblast growth factor 12 isoform 1						cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)														---	---	---	---
ATP13A4	84239	broad.mit.edu	37	3	193128905	193128905	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193128905delA	uc003ftd.2	-						ATP13A4_uc010hzi.2_Intron	NM_032279	NP_115655			ATPase type 13A4						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)														---	---	---	---
ATP13A4	84239	broad.mit.edu	37	3	193182984	193182984	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193182984delT	uc003ftd.2	-						ATP13A4_uc003fte.1_Intron|ATP13A4_uc011bsr.1_Intron|ATP13A4_uc010hzi.2_Intron|ATP13A4_uc003ftf.3_Intron	NM_032279	NP_115655			ATPase type 13A4						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)														---	---	---	---
UBXN7	26043	broad.mit.edu	37	3	196118944	196118944	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196118944delA	uc003fwm.3	-						UBXN7_uc003fwn.3_Intron|UBXN7_uc010iae.2_Intron	NM_015562	NP_056377			UBX domain containing 7								protein binding			ovary(2)|pancreas(1)	3																		---	---	---	---
WDR53	348793	broad.mit.edu	37	3	196288494	196288494	+	Intron	DEL	A	-	-	rs113594168		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196288494delA	uc003fwt.2	-							NM_182627	NP_872433			WD repeat domain 53											breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	196395222	196395223	+	IGR	DEL	AG	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196395222_196395223delAG								LRRC33 (6350 upstream) : C3orf34 (37926 downstream)																																			---	---	---	---
PIGX	54965	broad.mit.edu	37	3	196454585	196454585	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196454585delT	uc010iaj.2	+						PIGX_uc003fwx.3_Intron|PIGX_uc011btx.1_Intron	NM_017861	NP_060331			phosphatidylinositol glycan anchor biosynthesis,						C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00322)														---	---	---	---
DLG1	1739	broad.mit.edu	37	3	197023514	197023514	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197023514delA	uc003fxo.3	-						DLG1_uc003fxn.3_Intron|DLG1_uc011bue.1_Intron|DLG1_uc010ial.2_Intron|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_Intron|DLG1_uc010iam.1_Intron|uc003fxq.2_5'Flank	NM_001098424	NP_001091894			discs, large homolog 1 isoform 1						actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)														---	---	---	---
FYTTD1	84248	broad.mit.edu	37	3	197508915	197508916	+	3'UTR	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197508915_197508916delTT	uc003fyi.2	+	9					FYTTD1_uc011bui.1_3'UTR|FYTTD1_uc011buj.1_RNA|FYTTD1_uc011buk.1_3'UTR	NM_032288	NP_115664			forty-two-three domain containing 1 isoform 1						mRNA export from nucleus	nuclear speck	mRNA binding|protein binding				0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)														---	---	---	---
IQCG	84223	broad.mit.edu	37	3	197670508	197670508	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197670508delA	uc003fyo.2	-						IQCG_uc003fyp.2_Intron|IQCG_uc003fyq.3_Intron	NM_001134435	NP_001127907			IQ motif containing G												0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)														---	---	---	---
NAT8L	339983	broad.mit.edu	37	4	2065299	2065300	+	Intron	INS	-	GG	GG			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2065299_2065300insGG	uc003geq.1	+							NM_178557	NP_848652			N-acetyltransferase 8-like (GCN5-related,							integral to membrane|microsome|mitochondrial membrane|rough endoplasmic reticulum membrane	aspartate N-acetyltransferase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0315)															---	---	---	---
NOP14	8602	broad.mit.edu	37	4	2958218	2958218	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2958218delA	uc003ggj.1	-						C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_5'Flank|NOP14_uc003ggk.3_Intron|NOP14_uc003ggl.2_Intron|NOP14_uc010icq.1_Intron	NM_003703	NP_003694			probable nucleolar complex protein 14						endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1																		---	---	---	---
TMEM128	85013	broad.mit.edu	37	4	4249139	4249140	+	Intron	INS	-	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:4249139_4249140insT	uc003ghr.1	-						TMEM128_uc003ghq.1_Intron|TMEM128_uc003ghs.2_Intron|TMEM128_uc011bvv.1_Intron|TMEM128_uc011bvw.1_Intron	NM_032927	NP_116316			transmembrane protein 128							integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)														---	---	---	---
SH3TC1	54436	broad.mit.edu	37	4	8242814	8242815	+	3'UTR	DEL	TT	-	-	rs67520179		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8242814_8242815delTT	uc003gkv.3	+	18					SH3TC1_uc003gkw.3_3'UTR|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_RNA	NM_018986	NP_061859			SH3 domain and tetratricopeptide repeats 1								binding			large_intestine(2)|pancreas(1)	3																		---	---	---	---
WDR1	9948	broad.mit.edu	37	4	10099543	10099550	+	Intron	DEL	AAAAAAAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10099543_10099550delAAAAAAAA	uc003gmf.2	-						WDR1_uc003gmg.2_Intron	NM_017491	NP_059830			WD repeat-containing protein 1 isoform 1						platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)														---	---	---	---
PPARGC1A	10891	broad.mit.edu	37	4	23825732	23825732	+	Intron	DEL	T	-	-	rs56881226	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:23825732delT	uc003gqs.2	-						PPARGC1A_uc003gqt.2_Intron|PPARGC1A_uc011bxp.1_Intron|PPARGC1A_uc010ier.1_Intron	NM_013261	NP_037393			peroxisome proliferator-activated receptor						androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)																---	---	---	---
Unknown	0	broad.mit.edu	37	4	25497611	25497612	+	IGR	INS	-	CTTT	CTTT	rs144415784	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25497611_25497612insCTTT								ANAPC4 (77492 upstream) : SLC34A2 (159823 downstream)																																			---	---	---	---
WDR19	57728	broad.mit.edu	37	4	39217323	39217323	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39217323delA	uc003gtv.2	+						WDR19_uc010ifl.1_Intron|WDR19_uc003gtu.1_Intron|WDR19_uc011byi.1_Intron|WDR19_uc003gtw.1_5'Flank	NM_025132	NP_079408			WD repeat domain 19						cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1																		---	---	---	---
UGDH	7358	broad.mit.edu	37	4	39505928	39505928	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39505928delA	uc003guk.1	-						UGDH_uc011byp.1_Intron|UGDH_uc003gul.1_Intron	NM_003359	NP_003350			UDP-glucose dehydrogenase						glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)													---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48625212	48625213	+	Intron	DEL	AC	-	-	rs776579	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48625212_48625213delAC	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyl.1_Intron|FRYL_uc003gym.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
DCUN1D4	23142	broad.mit.edu	37	4	52731147	52731147	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52731147delT	uc003gze.2	+						DCUN1D4_uc003gzf.2_Intron|DCUN1D4_uc011bzn.1_Intron|DCUN1D4_uc003gzg.2_Intron|DCUN1D4_uc003gzh.2_Intron|DCUN1D4_uc011bzo.1_Intron	NM_001040402	NP_001035492			DCN1, defective in cullin neddylation 1, domain											ovary(2)	2			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)															---	---	---	---
DCUN1D4	23142	broad.mit.edu	37	4	52757912	52757912	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52757912delT	uc003gze.2	+						DCUN1D4_uc003gzf.2_Intron|DCUN1D4_uc011bzn.1_Intron|DCUN1D4_uc003gzg.2_Intron|DCUN1D4_uc003gzh.2_Intron|DCUN1D4_uc011bzo.1_Intron	NM_001040402	NP_001035492			DCN1, defective in cullin neddylation 1, domain											ovary(2)	2			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)															---	---	---	---
SPATA18	132671	broad.mit.edu	37	4	52960615	52960615	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52960615delA	uc003gzl.2	+						SPATA18_uc010igl.1_Intron|SPATA18_uc011bzq.1_Intron	NM_145263	NP_660306			spermatogenesis associated 18 homolog						mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)															---	---	---	---
PDGFRA	5156	broad.mit.edu	37	4	54255951	54255951	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54255951delT	uc003haa.2	+						FIP1L1_uc003gzx.3_Intron|FIP1L1_uc011bzt.1_Intron|FIP1L1_uc003gzy.2_Intron|FIP1L1_uc011bzu.1_Intron|FIP1L1_uc003gzz.2_Intron|FIP1L1_uc003hab.2_Intron|FIP1L1_uc003hac.2_Intron	NM_006206	NP_006197			platelet-derived growth factor receptor alpha						cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			---	---	---	---
Unknown	0	broad.mit.edu	37	4	69148151	69148151	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69148151delA								TMPRSS11B (36739 upstream) : YTHDC1 (27955 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	4	69444612	69444612	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69444612delT								YTHDC1 (228788 upstream) : UGT2B15 (67704 downstream)																																			---	---	---	---
SDAD1	55153	broad.mit.edu	37	4	76891638	76891638	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76891638delA	uc003hje.3	-						SDAD1_uc003hjf.3_Intron|SDAD1_uc011cbr.1_Intron	NM_018115	NP_060585			SDA1 domain containing 1						protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
CCDC158	339965	broad.mit.edu	37	4	77272457	77272457	+	Intron	DEL	A	-	-	rs112268994		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77272457delA	uc003hkb.3	-							NM_001042784	NP_001036249			coiled-coil domain containing 158											skin(3)|ovary(2)|pancreas(1)	6																		---	---	---	---
MANBA	4126	broad.mit.edu	37	4	103673002	103673002	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:103673002delA	uc003hwg.2	-						MANBA_uc011ces.1_Intron	NM_005908	NP_005899			mannosidase, beta A, lysosomal precursor						carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114289147	114289147	+	Intron	DEL	A	-	-	rs55966162	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114289147delA	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
SMARCA5	8467	broad.mit.edu	37	4	144442477	144442477	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:144442477delT	uc003ijg.2	+							NM_003601	NP_003592			SWI/SNF-related matrix-associated						CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)																	---	---	---	---
Unknown	0	broad.mit.edu	37	4	166469229	166469236	+	IGR	DEL	AATGTTAT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166469229_166469236delAATGTTAT								CPE (49748 upstream) : TLL1 (325174 downstream)																																			---	---	---	---
TLL1	7092	broad.mit.edu	37	4	166910816	166910817	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166910816_166910817delTT	uc003irh.1	+						TLL1_uc011cjn.1_Intron|TLL1_uc011cjo.1_Intron	NM_012464	NP_036596			tolloid-like 1 precursor						cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)														---	---	---	---
PALLD	23022	broad.mit.edu	37	4	169824745	169824746	+	Intron	INS	-	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169824745_169824746insT	uc011cjx.1	+						CBR4_uc011cjy.1_Intron|PALLD_uc003iru.2_Intron|PALLD_uc003irv.2_Intron|PALLD_uc003irw.2_Intron|PALLD_uc003irx.2_Intron	NM_016081	NP_057165			palladin isoform 2						cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)										Pancreatic_Cancer_Familial_Clustering_of				---	---	---	---
NEK1	4750	broad.mit.edu	37	4	170522990	170522990	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:170522990delA	uc003isb.1	-						NEK1_uc003isc.1_Intron|NEK1_uc003isd.1_Intron|NEK1_uc003ise.1_Intron|NEK1_uc003isf.1_Intron|NEK1_uc003isg.1_5'Flank	NM_012224	NP_036356			NIMA-related kinase 1						cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183673227	183673229	+	Intron	DEL	AAA	-	-	rs33920890		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183673227_183673229delAAA	uc003ivd.1	+						ODZ3_uc003ive.1_Intron	NM_001080477	NP_001073946			odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13923716	13923716	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13923716delA	uc003jfd.2	-						DNAH5_uc003jfe.1_Intron	NM_001369	NP_001360			dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	31840576	31840576	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31840576delT	uc003jhl.2	+						PDZD2_uc003jhm.2_Intron	NM_178140	NP_835260			PDZ domain containing 2						cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
ZFR	51663	broad.mit.edu	37	5	32356134	32356134	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32356134delA	uc003jhr.1	-						ZFR_uc010ium.1_Intron|ZFR_uc011cny.1_Intron	NM_016107	NP_057191			zinc finger RNA binding protein						multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)														---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	36885172	36885172	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36885172delT	uc003jkl.3	+						NIPBL_uc003jkk.3_Intron	NM_133433	NP_597677			delangin isoform A						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
NUP155	9631	broad.mit.edu	37	5	37292320	37292320	+	Intron	DEL	T	-	-	rs34382591		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37292320delT	uc003jku.1	-						NUP155_uc003jkt.1_Intron|NUP155_uc010iuz.1_Intron	NM_153485	NP_705618			nucleoporin 155kDa isoform 1						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
WDR70	55100	broad.mit.edu	37	5	37443325	37443326	+	Intron	INS	-	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37443325_37443326insT	uc003jkv.2	+						WDR70_uc010iva.1_Intron	NM_018034	NP_060504			WD repeat domain 70											ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
MAST4	375449	broad.mit.edu	37	5	66300755	66300755	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:66300755delT	uc003jut.1	+						MAST4_uc003jus.2_Intron|MAST4_uc003juu.1_Intron|MAST4_uc011cra.1_Intron|MAST4_uc010ixa.2_RNA|MAST4_uc003juv.2_5'UTR|MAST4_uc003juw.2_5'Flank	NM_015183	NP_055998			microtubule associated serine/threonine kinase							cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)														---	---	---	---
IQGAP2	10788	broad.mit.edu	37	5	75960694	75960694	+	Intron	DEL	A	-	-	rs79165446		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:75960694delA	uc003kek.2	+						IQGAP2_uc010izv.2_Intron|IQGAP2_uc011csv.1_Intron|IQGAP2_uc003kel.2_Intron	NM_006633	NP_006624			IQ motif containing GTPase activating protein 2						small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)														---	---	---	---
ARSB	411	broad.mit.edu	37	5	78181753	78181753	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:78181753delA	uc003kfq.2	-						ARSB_uc003kfr.3_Intron	NM_000046	NP_000037			arylsulfatase B isoform 1 precursor						lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)														---	---	---	---
BHMT2	23743	broad.mit.edu	37	5	78373610	78373611	+	Intron	DEL	CT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:78373610_78373611delCT	uc003kft.2	+						BHMT2_uc011cth.1_Intron	NM_017614	NP_060084			betaine-homocysteine methyltransferase 2						methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)													---	---	---	---
XRCC4	7518	broad.mit.edu	37	5	82575785	82575785	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82575785delG	uc003kib.2	+						XRCC4_uc003kia.1_Intron|XRCC4_uc003kid.2_Intron|XRCC4_uc003kic.2_Intron|XRCC4_uc003kie.2_Intron|XRCC4_uc003kig.2_Intron	NM_022406	NP_071801			X-ray repair cross complementing protein 4						DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			skin(3)	3		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)									NHEJ					---	---	---	---
RASA1	5921	broad.mit.edu	37	5	86644899	86644899	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:86644899delA	uc003kiw.2	+						RASA1_uc010jav.2_Intron|RASA1_uc003kix.2_Intron|RASA1_uc011ctv.1_Intron|RASA1_uc011ctw.1_Intron|RASA1_uc010jaw.2_Intron	NM_002890	NP_002881			RAS p21 protein activator 1 isoform 1						cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	96392026	96392026	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96392026delA								LNPEP (26911 upstream) : LIX1 (35549 downstream)																																			---	---	---	---
ATG12	9140	broad.mit.edu	37	5	115173167	115173167	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:115173167delA	uc003krh.2	-						ATG12_uc003kri.2_Intron|ATG12_uc003krj.2_Intron	NM_004707	NP_004698			APG12 autophagy 12-like						autophagic vacuole assembly|negative regulation of type I interferon production	pre-autophagosomal structure membrane	protein binding				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;7.59e-08)|Epithelial(69;7.05e-07)|all cancers(49;3.11e-05)														---	---	---	---
HSD17B4	3295	broad.mit.edu	37	5	118867259	118867260	+	Intron	DEL	GG	-	-	rs112037211		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118867259_118867260delGG	uc003ksj.2	+						HSD17B4_uc011cwg.1_Intron|HSD17B4_uc011cwh.1_Intron|HSD17B4_uc011cwi.1_Intron|HSD17B4_uc003ksk.3_Intron|HSD17B4_uc011cwj.1_Intron|HSD17B4_uc010jcn.1_Intron|HSD17B4_uc010jco.1_Intron	NM_000414	NP_000405			hydroxysteroid (17-beta) dehydrogenase 4						bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)													---	---	---	---
SNX24	28966	broad.mit.edu	37	5	122272417	122272417	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122272417delT	uc011cwo.1	+						SNX24_uc003ktf.2_Intron|SNX24_uc010jcy.2_Intron	NM_014035	NP_054754			SBBI31 protein						cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)														---	---	---	---
CEP120	153241	broad.mit.edu	37	5	122718020	122718022	+	Intron	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122718020_122718022delAAA	uc003ktk.2	-						CEP120_uc011cwq.1_Intron|CEP120_uc010jcz.1_Intron	NM_153223	NP_694955			coiled-coil domain containing 100							centrosome				ovary(1)	1																		---	---	---	---
CSNK1G3	1456	broad.mit.edu	37	5	122950255	122950256	+	3'UTR	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122950255_122950256delTT	uc003ktm.2	+	13					CSNK1G3_uc003ktl.2_3'UTR|CSNK1G3_uc003ktn.2_3'UTR|CSNK1G3_uc003kto.2_3'UTR|CSNK1G3_uc011cwr.1_3'UTR|CSNK1G3_uc011cws.1_3'UTR|CSNK1G3_uc010jda.2_3'UTR	NM_004384	NP_004375			casein kinase 1, gamma 3 isoform 1						Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)														---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127700150	127700151	+	Intron	INS	-	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127700150_127700151insT	uc003kuu.2	-						FBN2_uc003kuv.2_Intron	NM_001999	NP_001990			fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
LYRM7	90624	broad.mit.edu	37	5	130515638	130515638	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130515638delT	uc003kvg.1	+							NM_181705	NP_859056			Lyrm7 homolog												0		all_cancers(142;0.0377)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
KIF3A	11127	broad.mit.edu	37	5	132035887	132035887	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132035887delT	uc003kxo.2	-						KIF3A_uc003kxm.2_Intron|KIF3A_uc003kxn.2_Intron|KIF3A_uc011cxf.1_Intron|KIF3A_uc003kxp.2_Intron	NM_007054	NP_008985			kinesin family member 3A						blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
FAM13B	51306	broad.mit.edu	37	5	137346647	137346652	+	Intron	DEL	AAAAAA	-	-	rs71835602		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137346647_137346652delAAAAAA	uc003lbz.2	-						FAM13B_uc003lcb.2_Intron|FAM13B_uc003lca.2_Intron	NM_016603	NP_057687			hypothetical protein LOC51306 isoform 1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0																		---	---	---	---
PCDHGC5	56097	broad.mit.edu	37	5	140878622	140878624	+	Intron	DEL	GAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140878622_140878624delGAA	uc003lla.1	+						PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc003lky.1_Intron	NM_018929	NP_061752			protocadherin gamma subfamily C, 5 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
RNF14	9604	broad.mit.edu	37	5	141354197	141354197	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141354197delT	uc003lly.2	+						RNF14_uc003llz.2_Intron|RNF14_uc003lma.2_Intron|RNF14_uc003lmb.2_Intron|RNF14_uc003lmc.2_Intron|RNF14_uc011dbg.1_Intron|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Intron	NM_183399	NP_899646			ring finger protein 14 isoform 1						androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)														---	---	---	---
ARHGAP26	23092	broad.mit.edu	37	5	142601509	142601516	+	Intron	DEL	GGAAGGAT	-	-	rs148574726	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:142601509_142601516delGGAAGGAT	uc011dbj.1	+						ARHGAP26_uc003lmt.2_Intron|ARHGAP26_uc003lmw.2_Intron	NM_015071	NP_055886			GTPase regulator associated with the focal						actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
TCERG1	10915	broad.mit.edu	37	5	145888976	145888978	+	Intron	DEL	TTT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145888976_145888978delTTT	uc003lob.2	+						TCERG1_uc003loc.2_Intron	NM_006706	NP_006697			transcription elongation regulator 1 isoform 1						regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
STK32A	202374	broad.mit.edu	37	5	146730738	146730738	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:146730738delT	uc010jgn.1	+						STK32A_uc003lom.2_Intron|STK32A_uc011dbw.1_Intron	NM_001112724	NP_001106195			serine/threonine kinase 32A isoform 1								ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
GLRA1	2741	broad.mit.edu	37	5	151234889	151234890	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:151234889_151234890insA	uc003lut.2	-						GLRA1_uc003lur.2_Intron|GLRA1_uc003lus.2_Intron	NM_001146040	NP_001139512			glycine receptor, alpha 1 isoform 1 precursor						muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
ODZ2	57451	broad.mit.edu	37	5	167488974	167488974	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167488974delA	uc010jjd.2	+						ODZ2_uc003lzq.2_Intron|ODZ2_uc003lzr.3_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)														---	---	---	---
NPM1	4869	broad.mit.edu	37	5	170819655	170819655	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170819655delT	uc011dex.1	+						NPM1_uc003mbh.2_Intron|NPM1_uc003mbi.2_Intron|NPM1_uc003mbj.2_Intron	NM_002520	NP_002511			nucleophosmin 1 isoform 1						anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	haematopoietic_and_lymphoid_tissue(3109)|skin(1)	3110	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)					T|F 	ALK|RARA|MLF1	NHL|APL|AML								---	---	---	---
NOP16	51491	broad.mit.edu	37	5	175814080	175814080	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175814080delT	uc011dfl.1	-						NOP16_uc003med.2_Intron|NOP16_uc003mee.2_Intron|NOP16_uc011dfm.1_Intron|HIGD2A_uc003meg.2_5'Flank	NM_016391	NP_057475			NOP16 nucleolar protein homolog							nucleolus				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
BTNL8	79908	broad.mit.edu	37	5	180365545	180365545	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180365545delT	uc003mmp.2	+						BTNL8_uc003mmq.2_Intron|BTNL8_uc011dhg.1_Intron|BTNL8_uc010jll.2_Intron|BTNL8_uc010jlm.2_Intron|BTNL8_uc011dhh.1_Intron	NM_001040462	NP_001035552			butyrophilin-like 8 isoform 2 precursor							integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
DSP	1832	broad.mit.edu	37	6	7566746	7566746	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7566746delA	uc003mxp.1	+						DSP_uc003mxq.1_Intron	NM_004415	NP_004406			desmoplakin isoform I						cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)														---	---	---	---
SLC35B3	51000	broad.mit.edu	37	6	8417605	8417605	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:8417605delT	uc010joe.2	-						SLC35B3_uc003mya.2_Intron|SLC35B3_uc003myc.2_Intron|SLC35B3_uc003myb.2_Intron|SLC35B3_uc011did.1_Intron|SLC35B3_uc003myd.2_Intron	NM_001142541	NP_001136013			solute carrier family 35, member B3						transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)																	---	---	---	---
Unknown	0	broad.mit.edu	37	6	41276458	41276458	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41276458delT								TREM1 (22001 upstream) : NCR2 (27070 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	6	45834106	45834107	+	IGR	DEL	CT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:45834106_45834107delCT								RUNX2 (315288 upstream) : CLIC5 (32083 downstream)																																			---	---	---	---
CRISP3	10321	broad.mit.edu	37	6	49701364	49701365	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49701364_49701365delTT	uc003ozs.2	-							NM_006061	NP_006052			cysteine-rich secretory protein 3 precursor						innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)															---	---	---	---
COL21A1	81578	broad.mit.edu	37	6	56047463	56047463	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56047463delA	uc003pcs.2	-						COL21A1_uc003pct.1_Intron|COL21A1_uc011dxi.1_Intron|COL21A1_uc003pcu.1_Intron	NM_030820	NP_110447			collagen, type XXI, alpha 1 precursor						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)															---	---	---	---
BAI3	577	broad.mit.edu	37	6	70049069	70049069	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70049069delA	uc003pev.3	+						BAI3_uc010kak.2_Intron|BAI3_uc011dxx.1_Intron|BAI3_uc003pex.1_Intron	NM_001704	NP_001695			brain-specific angiogenesis inhibitor 3						negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)																---	---	---	---
Unknown	0	broad.mit.edu	37	6	71063390	71063391	+	IGR	DEL	TC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71063390_71063391delTC								COL9A1 (50604 upstream) : FAM135A (59716 downstream)																																			---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75852055	75852055	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75852055delA	uc003phs.2	-						COL12A1_uc003pht.2_Intron	NM_004370	NP_004361			collagen, type XII, alpha 1 long isoform						cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
SENP6	26054	broad.mit.edu	37	6	76421202	76421202	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76421202delT	uc003pid.3	+						SENP6_uc003pie.3_Intron|SENP6_uc010kbf.2_Intron	NM_015571	NP_056386			SUMO1/sentrin specific peptidase 6 isoform 1						proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)																---	---	---	---
CGA	1081	broad.mit.edu	37	6	87797955	87797956	+	Intron	DEL	AC	-	-	rs71944433		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:87797955_87797956delAC	uc003plj.1	-							NM_000735	NP_000726			glycoprotein hormones, alpha polypeptide						hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			ovary(1)	1		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)														---	---	---	---
SLC35A1	10559	broad.mit.edu	37	6	88218355	88218355	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88218355delT	uc011dzj.1	+						SLC35A1_uc003plx.2_Intron|SLC35A1_uc010kbw.2_Intron|SLC35A1_uc003plz.2_Intron|SLC35A1_uc011dzi.1_Intron|SLC35A1_uc003ply.2_Intron|SLC35A1_uc010kbx.2_Intron|SLC35A1_uc010kby.2_Intron|SLC35A1_uc011dzk.1_RNA	NM_006416	NP_006407			solute carrier family 35 (CMP-sialic acid						carbohydrate metabolic process|protein modification process	Golgi membrane|integral to plasma membrane	CMP-N-acetylneuraminate transmembrane transporter activity|sugar:hydrogen symporter activity				0		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
RARS2	57038	broad.mit.edu	37	6	88228194	88228194	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88228194delT	uc003pme.2	-						RARS2_uc003pmb.2_Intron|RARS2_uc003pmc.2_Intron|RARS2_uc003pmd.2_Intron|RARS2_uc003pmf.2_Intron	NM_020320	NP_064716			arginyl-tRNA synthetase 2, mitochondrial						arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)														---	---	---	---
UBE2J1	51465	broad.mit.edu	37	6	90039849	90039849	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90039849delA	uc010kcb.2	-						UBE2J1_uc003pnc.2_Intron	NM_016021	NP_057105			ubiquitin-conjugating enzyme E2, J1							endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)														---	---	---	---
MAP3K7	6885	broad.mit.edu	37	6	91246268	91246269	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:91246268_91246269delAA	uc003pnz.1	-						MAP3K7_uc003pny.1_5'UTR|MAP3K7_uc003poa.1_Intron|MAP3K7_uc003pob.1_Intron|MAP3K7_uc003poc.1_Intron	NM_145331	NP_663304			mitogen-activated protein kinase kinase kinase 7						activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
KLHL32	114792	broad.mit.edu	37	6	97532863	97532864	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97532863_97532864delTT	uc010kcm.1	+						KLHL32_uc003poy.2_Intron|KLHL32_uc011ead.1_Intron|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Intron|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136			kelch-like 32											ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)														---	---	---	---
SFRS18	25957	broad.mit.edu	37	6	99852665	99852665	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99852665delT	uc003ppo.3	-						SFRS18_uc003ppp.3_Intron|SFRS18_uc011eag.1_Intron	NM_032870	NP_116259			splicing factor, arginine/serine-rich 130							nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)														---	---	---	---
BVES	11149	broad.mit.edu	37	6	105563803	105563803	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:105563803delA	uc003pqw.2	-						BVES_uc003pqx.2_Intron|BVES_uc003pqy.2_Intron	NM_147147	NP_671488			blood vessel epicardial substance isoform 5						epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)																---	---	---	---
AIM1	202	broad.mit.edu	37	6	107008550	107008550	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:107008550delT	uc003prh.2	+						AIM1_uc003pri.2_Intron	NM_001624	NP_001615			absent in melanoma 1								sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)														---	---	---	---
CDC40	51362	broad.mit.edu	37	6	110530267	110530267	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110530267delT	uc003pua.2	+							NM_015891	NP_056975			cell division cycle 40 homolog						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)														---	---	---	---
KPNA5	3841	broad.mit.edu	37	6	117026119	117026119	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117026119delT	uc003pxh.2	+							NM_002269	NP_002260			karyopherin alpha 5						NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)														---	---	---	---
C6orf170	221322	broad.mit.edu	37	6	121643100	121643100	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121643100delT	uc003pyo.1	-						C6orf170_uc003pyq.1_Intron	NM_152730	NP_689943			hypothetical protein LOC221322						multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)														---	---	---	---
SLC2A12	154091	broad.mit.edu	37	6	134312046	134312046	+	3'UTR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:134312046delT	uc003qem.1	-	5						NM_145176	NP_660159			solute carrier family 2 (facilitated glucose							endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)														---	---	---	---
LOC153910	153910	broad.mit.edu	37	6	142860299	142860299	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:142860299delT	uc003qjc.1	-						LOC153910_uc010khg.1_Intron	NR_027312				Homo sapiens cDNA FLJ31371 fis, clone NB9N42000196.												0																		---	---	---	---
UTRN	7402	broad.mit.edu	37	6	145167776	145167776	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:145167776delA	uc003qkt.2	+							NM_007124	NP_009055			utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
PLEKHG1	57480	broad.mit.edu	37	6	151140702	151140704	+	Intron	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151140702_151140704delAAA	uc003qny.1	+						PLEKHG1_uc011eel.1_Intron|PLEKHG1_uc011eem.1_Intron|PLEKHG1_uc003qnz.2_Intron	NM_001029884	NP_001025055			pleckstrin homology domain containing, family G						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)														---	---	---	---
C6orf97	80129	broad.mit.edu	37	6	151917439	151917439	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151917439delA	uc003qol.2	+							NM_025059	NP_079335			hypothetical protein LOC80129												0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)														---	---	---	---
EZR	7430	broad.mit.edu	37	6	159210276	159210276	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:159210276delT	uc003qrt.3	-						EZR_uc011efs.1_Intron|EZR_uc003qru.3_Intron	NM_003379	NP_003370			ezrin						actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)														---	---	---	---
LPAL2	80350	broad.mit.edu	37	6	160887595	160887595	+	RNA	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160887595delT	uc003qtj.2	-	10		c.1960delA				NR_028093				Homo sapiens cDNA FLJ43922 fis, clone TESTI4012406.												0		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)														---	---	---	---
MAP3K4	4216	broad.mit.edu	37	6	161491963	161491963	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161491963delT	uc003qtn.2	+						MAP3K4_uc010kkc.1_Intron|MAP3K4_uc003qto.2_Intron|MAP3K4_uc011efz.1_Intron|MAP3K4_uc011ega.1_Intron	NM_005922	NP_005913			mitogen-activated protein kinase kinase kinase 4						activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)														---	---	---	---
FGFR1OP	11116	broad.mit.edu	37	6	167438458	167438458	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167438458delT	uc003qvj.2	+						CCR6_uc003qvl.2_Intron|FGFR1OP_uc011egp.1_Intron|FGFR1OP_uc003qvk.2_Intron	NM_007045	NP_008976			FGFR1 oncogene partner isoform a						G2/M transition of mitotic cell cycle|microtubule anchoring|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation	centrosome|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity|protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(1)	1		Breast(66;1.48e-05)|Ovarian(120;0.0607)		OV - Ovarian serous cystadenocarcinoma(33;1.73e-19)|BRCA - Breast invasive adenocarcinoma(81;5.1e-06)|GBM - Glioblastoma multiforme(31;0.00231)				T	FGFR1	MPD|NHL								---	---	---	---
SMOC2	64094	broad.mit.edu	37	6	168949946	168949946	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:168949946delT	uc003qws.1	+						SMOC2_uc003qwr.1_Intron	NM_022138	NP_071421			SPARC related modular calcium binding 2						signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)														---	---	---	---
PHF10	55274	broad.mit.edu	37	6	170118766	170118766	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170118766delA	uc011egy.1	-						PHF10_uc011egz.1_Intron|PHF10_uc011eha.1_5'Flank	NM_018288	NP_060758			PHD finger protein 10 isoform a						nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	npBAF complex	zinc ion binding			urinary_tract(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.4e-21)|BRCA - Breast invasive adenocarcinoma(81;1.4e-07)|GBM - Glioblastoma multiforme(31;0.00176)														---	---	---	---
PMS2	5395	broad.mit.edu	37	7	6031805	6031806	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6031805_6031806delTT	uc003spl.2	-						PMS2_uc003spj.2_Intron|PMS2_uc003spk.2_Intron|PMS2_uc011jwl.1_Intron|PMS2_uc010ktg.2_Intron|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Intron	NM_000535	NP_000526			PMS2 postmeiotic segregation increased 2 isoform						mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)				Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---	---
PMS2CL	441194	broad.mit.edu	37	7	6781178	6781178	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6781178delA	uc003squ.2	+						PMS2CL_uc003sqv.1_Intron					Homo sapiens PMS2CL mRNA for PMS2-C terminal -like, complete cds.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	25417784	25417791	+	IGR	DEL	CCCTTCCC	-	-	rs75017634		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:25417784_25417791delCCCTTCCC								NPVF (149679 upstream) : MIR148A (571748 downstream)																																			---	---	---	---
HOXA4	3201	broad.mit.edu	37	7	27170396	27170396	+	5'UTR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27170396delT	uc003sym.3	-	1						NM_002141	NP_002132			homeobox A4							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1																		---	---	---	---
GARS	2617	broad.mit.edu	37	7	30662267	30662267	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30662267delT	uc003tbm.2	+							NM_002047	NP_002038			glycyl-tRNA synthetase						cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)													---	---	---	---
DPY19L1	23333	broad.mit.edu	37	7	34979749	34979751	+	Intron	DEL	TTT	-	-	rs72287078		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:34979749_34979751delTTT	uc003tem.3	-						DPY19L1_uc003tel.1_5'Flank	NM_015283	NP_056098			dpy-19-like 1							integral to membrane					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	55004034	55004034	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:55004034delT								SEC61G (177095 upstream) : EGFR (82691 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	63023116	63023116	+	IGR	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:63023116delC								LOC100287704 (210965 upstream) : ZNF727 (482705 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	65222951	65222951	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65222951delT	uc003tud.1	-						CCT6P1_uc003tug.2_Intron|CCT6P1_uc003tuh.2_Intron|CCT6P1_uc003tui.2_Intron|uc003tuk.1_5'Flank					Homo sapiens hypothetical LOC441242, mRNA (cDNA clone MGC:87648 IMAGE:5267764), complete cds.																														---	---	---	---
Unknown	0	broad.mit.edu	37	7	77612652	77612655	+	IGR	DEL	TCCC	-	-	rs35943083		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:77612652_77612655delTCCC								PHTF2 (25834 upstream) : MAGI2 (33720 downstream)																																			---	---	---	---
AKAP9	10142	broad.mit.edu	37	7	91622509	91622509	+	Intron	DEL	T	-	-	rs75639681		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91622509delT	uc003ulg.2	+						AKAP9_uc003uld.3_Intron|AKAP9_uc003ule.2_Intron|AKAP9_uc003ulf.2_Intron	NM_005751	NP_005742			A-kinase anchor protein 9 isoform 2						G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)					T	BRAF	papillary thyroid								---	---	---	---
CCDC132	55610	broad.mit.edu	37	7	92883251	92883251	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92883251delA	uc003umo.2	+						CCDC132_uc003umq.2_Intron|CCDC132_uc003ump.2_Intron|CCDC132_uc003umr.2_Intron|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Intron	NM_017667	NP_060137			coiled-coil domain containing 132 isoform a												0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
PDAP1	11333	broad.mit.edu	37	7	98994127	98994127	+	3'UTR	DEL	C	-	-	rs113663373		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98994127delC	uc003uqe.2	-	6						NM_014891	NP_055706			PDGFA associated protein 1						cell proliferation|signal transduction						0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)													---	---	---	---
STAG3	10734	broad.mit.edu	37	7	99778503	99778503	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99778503delG	uc003utx.1	+						STAG3_uc010lgs.1_Intron|STAG3_uc011kjk.1_Intron	NM_012447	NP_036579			stromal antigen 3						chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
STAG3	10734	broad.mit.edu	37	7	99780152	99780152	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99780152delT	uc003utx.1	+						STAG3_uc010lgs.1_Intron|STAG3_uc011kjk.1_Intron	NM_012447	NP_036579			stromal antigen 3						chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
PILRB	29990	broad.mit.edu	37	7	99943553	99943553	+	5'UTR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99943553delT	uc003uuk.2	+	4					PILRB_uc003uul.2_5'UTR	NM_013440	NP_038468			paired immunoglobulin-like type 2 receptor beta						activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
IFRD1	3475	broad.mit.edu	37	7	112112570	112112570	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:112112570delT	uc003vgh.2	+						IFRD1_uc011kmn.1_Intron|IFRD1_uc003vgj.2_Intron|IFRD1_uc011kmo.1_Intron|IFRD1_uc011kmp.1_Intron|IFRD1_uc003vgk.2_Intron	NM_001007245	NP_001007246			interferon-related developmental regulator 1						multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2																		---	---	---	---
FOXP2	93986	broad.mit.edu	37	7	114066449	114066449	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:114066449delC	uc003vhb.2	+						FOXP2_uc003vgu.2_Intron|FOXP2_uc003vgz.2_Intron|FOXP2_uc003vha.2_Intron|FOXP2_uc011kmu.1_Intron|FOXP2_uc011kmv.1_Intron|FOXP2_uc003vgt.1_Intron|FOXP2_uc003vgv.1_Intron|FOXP2_uc003vgw.2_Intron|FOXP2_uc003vgx.2_Intron|FOXP2_uc003vhd.2_5'Flank|FOXP2_uc003vhc.2_5'Flank	NM_014491	NP_055306			forkhead box P2 isoform I						camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8																		---	---	---	---
FAM3C	10447	broad.mit.edu	37	7	121022812	121022812	+	Intron	DEL	A	-	-	rs77488516		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121022812delA	uc003vjx.2	-						FAM3C_uc010lkm.2_Intron	NM_014888	NP_055703			family with sequence similarity 3, member C						multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity				0	all_neural(327;0.117)																	---	---	---	---
NRF1	4899	broad.mit.edu	37	7	129395139	129395139	+	3'UTR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129395139delT	uc003voz.2	+	11					NRF1_uc003vpa.2_3'UTR|NRF1_uc011kpa.1_3'UTR|NRF1_uc003vpb.2_3'UTR	NM_005011	NP_005002			nuclear respiratory factor 1						generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1																		---	---	---	---
COPG2	26958	broad.mit.edu	37	7	130148870	130148870	+	Intron	DEL	A	-	-	rs77402405		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130148870delA	uc003vqh.1	-							NM_012133	NP_036265			coatomer protein complex, subunit gamma 2						intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)																	---	---	---	---
JHDM1D	80853	broad.mit.edu	37	7	139820179	139820179	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139820179delA	uc003vvm.2	-						JHDM1D_uc010lng.2_5'Flank	NM_030647	NP_085150			jumonji C domain containing histone demethylase						midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)																	---	---	---	---
CUL1	8454	broad.mit.edu	37	7	148494795	148494801	+	Intron	DEL	TTTTTTT	-	-	rs72007939		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148494795_148494801delTTTTTTT	uc010lpg.2	+						CUL1_uc003wey.2_Intron|CUL1_uc003wez.2_Intron|CUL1_uc003wfa.2_Intron	NM_003592	NP_003583			cullin 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	2126807	2126807	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2126807delT								MYOM2 (33428 upstream) : CSMD1 (666069 downstream)																																			---	---	---	---
XKR5	389610	broad.mit.edu	37	8	6673270	6673270	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6673270delA	uc003wqp.2	-						XKR5_uc003wqq.2_Intron|XKR5_uc003wqr.1_Intron	NM_207411	NP_997294			XK-related protein 5a							integral to membrane					0			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)												OREG0018511	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
Unknown	0	broad.mit.edu	37	8	11189696	11189696	+	IGR	DEL	A	-	-	rs78909439		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11189696delA								AMAC1L2 (1 upstream) : TDH (7450 downstream)																																			---	---	---	---
MSR1	4481	broad.mit.edu	37	8	16035613	16035613	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:16035613delT	uc003wwz.2	-						MSR1_uc010lsu.2_Intron|MSR1_uc003wxa.2_Intron|MSR1_uc003wxb.2_Intron|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729			macrophage scavenger receptor 1 isoform type 1						cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)														---	---	---	---
CNOT7	29883	broad.mit.edu	37	8	17088040	17088040	+	3'UTR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17088040delT	uc003wxf.1	-	7					CNOT7_uc003wxg.1_3'UTR	NM_013354	NP_037486			CCR4-NOT transcription complex, subunit 7						carbohydrate metabolic process|nuclear-transcribed mRNA poly(A) tail shortening	CCR4-NOT complex|cytoplasmic mRNA processing body|cytosol	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1				Colorectal(111;0.0523)|COAD - Colon adenocarcinoma(73;0.209)														---	---	---	---
PPP2R2A	5520	broad.mit.edu	37	8	25902514	25902514	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25902514delA	uc003xek.2	+						EBF2_uc003xes.1_5'Flank|EBF2_uc003xet.1_5'Flank	NM_002717	NP_002708			alpha isoform of regulatory subunit B55, protein						protein dephosphorylation|signal transduction	protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			ovary(1)|kidney(1)	2		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)														---	---	---	---
C8orf80	389643	broad.mit.edu	37	8	27927265	27927265	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27927265delA	uc003xgm.3	-							NM_001010906	NP_001010906			speckled-like pattern in the germinal center							nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)														---	---	---	---
Unknown	0	broad.mit.edu	37	8	28158144	28158144	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28158144delA								ELP3 (109477 upstream) : PNOC (16505 downstream)																																			---	---	---	---
UNC5D	137970	broad.mit.edu	37	8	35606378	35606378	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:35606378delC	uc003xjr.1	+						UNC5D_uc003xjs.1_Intron|UNC5D_uc003xju.1_Intron	NM_080872	NP_543148			unc-5 homolog D precursor						apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)														---	---	---	---
DDHD2	23259	broad.mit.edu	37	8	38107444	38107444	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38107444delT	uc003xlb.2	+						DDHD2_uc003xlc.2_Intron|DDHD2_uc003xld.2_Intron	NM_015214	NP_056029			DDHD domain containing 2 isoform 1						lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)															---	---	---	---
LETM2	137994	broad.mit.edu	37	8	38265166	38265166	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38265166delA	uc003xlm.1	+						LETM2_uc003xll.1_Intron|LETM2_uc003xln.1_Intron|LETM2_uc003xlo.1_Intron	NM_144652	NP_653253			leucine zipper-EF-hand containing transmembrane							integral to membrane|mitochondrial inner membrane					0	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)															---	---	---	---
POLB	5423	broad.mit.edu	37	8	42199220	42199220	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42199220delT	uc003xoz.1	+						POLB_uc003xpa.1_Intron|POLB_uc011lcs.1_Intron	NM_002690	NP_002681			DNA-directed DNA polymerase beta						DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)								DNA_polymerases_(catalytic_subunits)					---	---	---	---
KIAA0146	23514	broad.mit.edu	37	8	48586205	48586205	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48586205delT	uc003xqd.2	+						KIAA0146_uc011ldb.1_Intron|KIAA0146_uc010lxs.2_Intron|KIAA0146_uc011ldc.1_Intron|KIAA0146_uc011ldd.1_Intron|KIAA0146_uc003xqe.2_Intron|KIAA0146_uc003xqf.2_Intron|KIAA0146_uc011lde.1_Intron|KIAA0146_uc010lxt.2_Intron|KIAA0146_uc011ldf.1_Intron|KIAA0146_uc011ldg.1_5'UTR|KIAA0146_uc010lxv.1_Intron	NM_001080394	NP_001073863			hypothetical protein LOC23514												0		Lung NSC(58;0.175)																---	---	---	---
XKR4	114786	broad.mit.edu	37	8	56435701	56435701	+	Intron	DEL	A	-	-	rs35183687		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56435701delA	uc003xsf.2	+							NM_052898	NP_443130			XK, Kell blood group complex subunit-related							integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)															---	---	---	---
LYN	4067	broad.mit.edu	37	8	56815414	56815414	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56815414delT	uc003xsk.3	+						LYN_uc003xsl.3_Intron	NM_002350	NP_002341			Yamaguchi sarcoma viral (v-yes-1) oncogene						erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)															---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61714076	61714076	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61714076delT	uc003xue.2	+							NM_017780	NP_060250			chromodomain helicase DNA binding protein 7						central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
ADHFE1	137872	broad.mit.edu	37	8	67357336	67357336	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67357336delA	uc003xwb.3	+						ADHFE1_uc003xwd.3_Intron|ADHFE1_uc003xwc.3_Intron|ADHFE1_uc003xwe.3_Intron|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Intron|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251			alcohol dehydrogenase, iron containing, 1						2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)															---	---	---	---
TRPA1	8989	broad.mit.edu	37	8	72969255	72969255	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:72969255delA	uc003xza.2	-							NM_007332	NP_015628			ankyrin-like protein 1							integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)													---	---	---	---
GDAP1	54332	broad.mit.edu	37	8	75275006	75275007	+	Intron	INS	-	CT	CT	rs140955331	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75275006_75275007insCT	uc003yah.2	+						GDAP1_uc011lfj.1_Intron|GDAP1_uc003yai.2_Intron	NM_018972	NP_061845			ganglioside-induced differentiation-associated							cytoplasm					0	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)															---	---	---	---
OSGIN2	734	broad.mit.edu	37	8	90921779	90921779	+	Intron	DEL	T	-	-	rs73696834	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90921779delT	uc003yeg.2	+						OSGIN2_uc003yeh.2_Intron	NM_004337	NP_004328			oxidative stress induced growth inhibitor family						germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)															---	---	---	---
OSGIN2	734	broad.mit.edu	37	8	90936586	90936586	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90936586delT	uc003yeg.2	+						OSGIN2_uc003yeh.2_Intron	NM_004337	NP_004328			oxidative stress induced growth inhibitor family						germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)															---	---	---	---
NECAB1	64168	broad.mit.edu	37	8	91967809	91967809	+	3'UTR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:91967809delA	uc011lgg.1	+	13					NECAB1_uc003yer.2_3'UTR	NM_022351	NP_071746			N-terminal EF-hand calcium binding protein 1						antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100833442	100833442	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100833442delA	uc003yiv.2	+						VPS13B_uc003yiw.2_Intron	NM_017890	NP_060360			vacuolar protein sorting 13B isoform 5						protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
NCALD	83988	broad.mit.edu	37	8	102859464	102859464	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:102859464delT	uc003ykf.2	-						NCALD_uc003ykg.2_Intron|NCALD_uc003ykh.2_Intron|NCALD_uc003yki.2_Intron|NCALD_uc003ykj.2_Intron|NCALD_uc003ykk.2_Intron|NCALD_uc003ykl.2_Intron	NM_001040628	NP_001035718			neurocalcin delta						synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)															---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113363350	113363350	+	Intron	DEL	T	-	-	rs7003308	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113363350delT	uc003ynu.2	-						CSMD3_uc003yns.2_Intron|CSMD3_uc003ynt.2_Intron|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756			CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113702411	113702411	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113702411delT	uc003ynu.2	-						CSMD3_uc003yns.2_5'Flank|CSMD3_uc003ynt.2_Intron|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756			CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
EIF3H	8667	broad.mit.edu	37	8	117668365	117668365	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117668365delA	uc003yoa.2	-						EIF3H_uc003yob.2_Intron	NM_003756	NP_003747			eukaryotic translation initiation factor 3,						regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)																	---	---	---	---
RAD21	5885	broad.mit.edu	37	8	117869182	117869182	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117869182delA	uc003yod.2	-							NM_006265	NP_006256			RAD21 homolog						apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)																	---	---	---	---
DEPDC6	64798	broad.mit.edu	37	8	120977791	120977792	+	Intron	INS	-	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120977791_120977792insG	uc003yow.3	+						DEPDC6_uc011lid.1_Intron	NM_022783	NP_073620			DEP domain containing 6						intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
SNTB1	6641	broad.mit.edu	37	8	121648291	121648291	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:121648291delT	uc010mdg.2	-						SNTB1_uc003ype.2_Intron	NM_021021	NP_066301			basic beta 1 syntrophin						muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)															---	---	---	---
FAM49B	51571	broad.mit.edu	37	8	130864676	130864676	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:130864676delT	uc003yss.2	-						FAM49B_uc003yst.2_Intron|FAM49B_uc003ysu.2_Intron|FAM49B_uc003ysv.2_Intron|FAM49B_uc003ysw.2_Intron|FAM49B_uc003ysx.2_Intron|FAM49B_uc003ysy.1_Intron	NM_016623	NP_057707			hypothetical protein LOC51571												0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)															---	---	---	---
FAM49B	51571	broad.mit.edu	37	8	130874724	130874724	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:130874724delT	uc003yss.2	-						FAM49B_uc003yst.2_Intron|FAM49B_uc003ysu.2_Intron|FAM49B_uc003ysv.2_Intron|FAM49B_uc003ysw.2_Intron|FAM49B_uc003ysx.2_Intron|FAM49B_uc003ysy.1_Intron	NM_016623	NP_057707			hypothetical protein LOC51571												0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)															---	---	---	---
ASAP1	50807	broad.mit.edu	37	8	131140419	131140420	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:131140419_131140420delAA	uc003yta.1	-						ASAP1_uc003ysz.1_Intron|ASAP1_uc011liw.1_Intron	NM_018482	NP_060952			development and differentiation enhancing factor						cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4																		---	---	---	---
TOP1MT	116447	broad.mit.edu	37	8	144405960	144405962	+	Intron	DEL	GCA	-	-	rs62524733	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144405960_144405962delGCA	uc003yxz.2	-						TOP1MT_uc011lkd.1_Intron|TOP1MT_uc011lke.1_Intron|TOP1MT_uc010mfb.2_Intron|TOP1MT_uc011lkf.1_Intron|TOP1MT_uc010mfd.1_Intron	NM_052963	NP_443195			mitochondrial topoisomerase I precursor						DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)													---	---	---	---
Unknown	0	broad.mit.edu	37	8	145073117	145073119	+	IGR	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145073117_145073119delAAA								GRINA (5534 upstream) : SPATC1 (13463 downstream)																																			---	---	---	---
DOCK8	81704	broad.mit.edu	37	9	386240	386240	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:386240delA	uc003zgf.2	+						DOCK8_uc010mgu.2_Intron|DOCK8_uc010mgv.2_Intron|DOCK8_uc010mgw.1_Intron|DOCK8_uc003zgk.2_Intron	NM_203447	NP_982272			dedicator of cytokinesis 8						blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)												OREG0019067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GLIS3	169792	broad.mit.edu	37	9	4126054	4126054	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4126054delT	uc003zhw.1	-						GLIS3_uc003zhx.1_Intron|GLIS3_uc003zic.1_Intron|GLIS3_uc003zie.1_Intron|GLIS3_uc010mhh.1_Intron|GLIS3_uc003zid.1_Intron|GLIS3_uc010mhi.1_Intron|GLIS3_uc003zif.1_Intron|GLIS3_uc003zig.1_Intron|GLIS3_uc003zih.1_Intron|GLIS3_uc003zib.1_Intron|GLIS3_uc010mhg.1_Intron	NM_152629	NP_689842			GLIS family zinc finger 3 isoform b						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)														---	---	---	---
RCL1	10171	broad.mit.edu	37	9	4849375	4849375	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4849375delT	uc003zis.2	+						RCL1_uc003zit.2_Intron|RCL1_uc010mhk.1_Intron|RCL1_uc010mhl.1_Intron	NM_005772	NP_005763			RNA terminal phosphate cyclase-like 1						ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)														---	---	---	---
INSL6	11172	broad.mit.edu	37	9	5185131	5185131	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5185131delA	uc003zix.2	-							NM_007179	NP_009110			insulin-like 6 precursor							extracellular region	hormone activity				0	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	15362204	15362204	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:15362204delA								TTC39B (54960 upstream) : SNAPC3 (60578 downstream)																																			---	---	---	---
CNTLN	54875	broad.mit.edu	37	9	17338168	17338168	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:17338168delT	uc003zmz.2	+						CNTLN_uc003zmy.2_Intron|CNTLN_uc010mio.2_Intron	NM_017738	NP_060208			centlein isoform 1							centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)														---	---	---	---
HAUS6	54801	broad.mit.edu	37	9	19096563	19096571	+	Intron	DEL	AAAAAAAAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19096563_19096571delAAAAAAAAA	uc003znk.2	-							NM_017645	NP_060115			HAUS augmin-like complex, subunit 6						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2																		---	---	---	---
MLLT3	4300	broad.mit.edu	37	9	20622294	20622295	+	5'UTR	INS	-	C	C	rs35653310		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20622294_20622295insC	uc003zoe.2	-	1					MLLT3_uc011lne.1_5'Flank|MLLT3_uc011lnf.1_5'Flank|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_5'Flank	NM_004529	NP_004520			myeloid/lymphoid or mixed-lineage leukemia						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)				T	MLL	ALL								---	---	---	---
ZCCHC7	84186	broad.mit.edu	37	9	37357250	37357250	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37357250delA	uc003zzq.2	+	9	1790	c.1617delA	c.(1615-1617)AGAfs	p.R539fs	ZCCHC7_uc011lqh.1_Frame_Shift_Del_p.R249fs|ZCCHC7_uc011lqi.1_Frame_Shift_Del_p.R538fs|ZCCHC7_uc010mlt.2_Frame_Shift_Del_p.R538fs	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	539							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)														---	---	---	---
SLC28A3	64078	broad.mit.edu	37	9	86895090	86895090	+	Intron	DEL	T	-	-	rs35540005		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86895090delT	uc010mpz.2	-						SLC28A3_uc011lsy.1_Intron|SLC28A3_uc004anu.1_Intron	NM_022127	NP_071410			concentrative Na+-nucleoside cotransporter						nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4																		---	---	---	---
CTNNAL1	8727	broad.mit.edu	37	9	111734764	111734764	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111734764delT	uc004bdo.1	-						CTNNAL1_uc010mts.1_Intron|CTNNAL1_uc010mtt.1_Intron|CTNNAL1_uc004bdp.1_Intron|CTNNAL1_uc004bdq.1_Intron	NM_003798	NP_003789			catenin, alpha-like 1						cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)														---	---	---	---
C9orf80	58493	broad.mit.edu	37	9	115451949	115451949	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115451949delT	uc004bgg.2	-						C9orf80_uc010muk.2_Intron	NM_021218	NP_067041			SOSSC protein						DNA repair|response to ionizing radiation	SOSS complex	protein binding				0																		---	---	---	---
TTC16	158248	broad.mit.edu	37	9	130485247	130485249	+	Intron	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130485247_130485249delAAA	uc004brq.1	+						PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Intron|TTC16_uc004brr.1_Intron|TTC16_uc010mxn.1_Intron	NM_144965	NP_659402			tetratricopeptide repeat domain 16								binding				0																		---	---	---	---
CCBL1	883	broad.mit.edu	37	9	131598531	131598532	+	Intron	DEL	TC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131598531_131598532delTC	uc004bwh.2	-						CCBL1_uc004bwf.2_Intron|CCBL1_uc004bwg.2_Intron|CCBL1_uc010myn.2_Intron|CCBL1_uc004bwj.2_Intron|CCBL1_uc011mbl.1_Intron|CCBL1_uc004bwi.2_Intron|CCBL1_uc010myo.2_Intron	NM_004059	NP_004050			kynurenine aminotransferase I isoform a						kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)													---	---	---	---
LAMC3	10319	broad.mit.edu	37	9	133928189	133928189	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133928189delC	uc004caa.1	+							NM_006059	NP_006050			laminin, gamma 3 precursor						cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)												OREG0019556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NELF	26012	broad.mit.edu	37	9	140350660	140350660	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140350660delG	uc004cna.2	-						C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_5'Flank|NELF_uc010nci.2_Intron|NELF_uc011mey.1_Intron|NELF_uc011mez.1_Intron|NELF_uc004cmz.2_Intron|NELF_uc004cnc.2_Intron|NELF_uc004cnb.2_Intron	NM_001130969	NP_001124441			nasal embryonic LHRH factor isoform a							nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)														---	---	---	---
CUBN	8029	broad.mit.edu	37	10	17169998	17169998	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17169998delA	uc001ioo.2	-							NM_001081	NP_001072			cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
NEBL	10529	broad.mit.edu	37	10	21097279	21097279	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21097279delA	uc001iqi.2	-						NEBL_uc001iqj.2_Intron|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384			nebulette sarcomeric isoform						regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2																		---	---	---	---
FRMPD2	143162	broad.mit.edu	37	10	49400634	49400634	+	Intron	DEL	A	-	-	rs74923642		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:49400634delA	uc001jgi.2	-						FRMPD2_uc001jgh.2_Intron|FRMPD2_uc001jgj.2_Intron	NM_001018071	NP_001018081			FERM and PDZ domain containing 2 isoform 3						tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)														---	---	---	---
ASCC1	51008	broad.mit.edu	37	10	73940733	73940734	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73940733_73940734delTT	uc001jst.1	-						ASCC1_uc001jsr.1_Intron|ASCC1_uc001jss.1_Intron|ASCC1_uc001jsu.1_Intron|ASCC1_uc010qju.1_Intron					RecName: Full=Activating signal cointegrator 1 complex subunit 1; AltName: Full=ASC-1 complex subunit p50; AltName: Full=Trip4 complex subunit p50;						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	RNA binding				0																		---	---	---	---
OIT3	170392	broad.mit.edu	37	10	74653469	74653470	+	5'UTR	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74653469_74653470delAA	uc001jte.1	+	1					OIT3_uc009xqs.1_RNA	NM_152635	NP_689848			oncoprotein-induced transcript 3 precursor							nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)																	---	---	---	---
ATAD1	84896	broad.mit.edu	37	10	89514658	89514658	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:89514658delA	uc001key.1	-						ATAD1_uc010qmr.1_Intron|ATAD1_uc009xth.1_Intron|ATAD1_uc001kez.1_Intron	NM_032810	NP_116199			ATPase family, AAA domain containing 1							peroxisome	ATP binding|nucleoside-triphosphatase activity			large_intestine(1)|ovary(1)	2		all_cancers(4;6.78e-12)|Prostate(4;3.56e-12)|all_epithelial(4;5.58e-09)|Melanoma(5;0.0273)|Breast(4;0.0424)|all_hematologic(4;0.0846)|Colorectal(252;0.207)|Glioma(4;0.217)|all_neural(4;0.224)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00131)|GBM - Glioblastoma multiforme(1;1.1e-32)|Lung(2;1.4e-05)|LUSC - Lung squamous cell carcinoma(2;2.69e-05)|Colorectal(12;7.09e-05)|COAD - Colon adenocarcinoma(12;0.000261)|STAD - Stomach adenocarcinoma(243;0.235)														---	---	---	---
TNKS2	80351	broad.mit.edu	37	10	93600113	93600113	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93600113delA	uc001khp.2	+							NM_025235	NP_079511			tankyrase, TRF1-interacting ankyrin-related						positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)																---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93748896	93748896	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93748896delT	uc001khr.2	+						BTAF1_uc001khs.1_Intron|BTAF1_uc001kht.1_Intron	NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
CPEB3	22849	broad.mit.edu	37	10	93904961	93904961	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93904961delA	uc001khw.1	-						CPEB3_uc001khu.1_Intron|CPEB3_uc001khv.1_Intron|CPEB3_uc010qnn.1_Intron	NM_014912	NP_055727			cytoplasmic polyadenylation element binding								nucleotide binding|RNA binding				0		Colorectal(252;0.0869)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	94143971	94143971	+	IGR	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94143971delC								MARCH5 (30250 upstream) : IDE (69629 downstream)																																			---	---	---	---
HELLS	3070	broad.mit.edu	37	10	96313731	96313731	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96313731delT	uc001kjt.2	+						HELLS_uc001kjs.2_Intron|HELLS_uc009xul.2_Intron|HELLS_uc009xum.2_Intron|HELLS_uc009xun.2_Intron|HELLS_uc009xuo.2_Intron|HELLS_uc001kju.2_Intron|HELLS_uc009xup.2_Intron|HELLS_uc009xuq.2_Intron|HELLS_uc009xur.2_Intron	NM_018063	NP_060533			helicase, lymphoid-specific						cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)														---	---	---	---
SORBS1	10580	broad.mit.edu	37	10	97106049	97106050	+	Intron	INS	-	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97106049_97106050insT	uc001kkp.2	-						SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Intron|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Intron	NM_001034954	NP_001030126			sorbin and SH3 domain containing 1 isoform 3						focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)														---	---	---	---
SORBS1	10580	broad.mit.edu	37	10	97131604	97131606	+	Intron	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97131604_97131606delAAA	uc001kkp.2	-						SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Intron|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Intron	NM_001034954	NP_001030126			sorbin and SH3 domain containing 1 isoform 3						focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)														---	---	---	---
MMS19	64210	broad.mit.edu	37	10	99221731	99221731	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99221731delA	uc001kns.3	-						MMS19_uc001knq.2_5'Flank|MMS19_uc009xvs.2_Intron|MMS19_uc009xvt.2_Intron|MMS19_uc001knr.2_Intron|MMS19_uc010qox.1_Intron|MMS19_uc001knt.2_Intron|MMS19_uc001knu.1_Intron	NM_022362	NP_071757			MMS19 nucleotide excision repair homolog						chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity				0		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)									Direct_reversal_of_damage|NER					---	---	---	---
SMC3	9126	broad.mit.edu	37	10	112350935	112350935	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112350935delT	uc001kze.2	+							NM_005445	NP_005436			structural maintenance of chromosomes 3						cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)														---	---	---	---
TCF7L2	6934	broad.mit.edu	37	10	114918647	114918648	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114918647_114918648delTT	uc001lae.3	+						TCF7L2_uc001lac.3_Intron|TCF7L2_uc010qrk.1_Intron|TCF7L2_uc010qrl.1_Intron|TCF7L2_uc010qrm.1_Intron|TCF7L2_uc010qrn.1_Intron|TCF7L2_uc001lad.3_Intron|TCF7L2_uc001lag.3_Intron|TCF7L2_uc001laf.3_Intron|TCF7L2_uc010qro.1_Intron|TCF7L2_uc001lah.2_Intron|TCF7L2_uc010qrp.1_Intron|TCF7L2_uc010qrq.1_Intron|TCF7L2_uc010qrr.1_Intron|TCF7L2_uc010qrs.1_Intron|TCF7L2_uc010qrt.1_Intron|TCF7L2_uc010qru.1_Intron|TCF7L2_uc010qrv.1_Intron|TCF7L2_uc010qrw.1_Intron|TCF7L2_uc010qrx.1_Intron	NM_001146274	NP_001139746			transcription factor 7-like 2 isoform 1						anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)														---	---	---	---
TCF7L2	6934	broad.mit.edu	37	10	114919590	114919596	+	Intron	DEL	CCCCCCC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114919590_114919596delCCCCCCC	uc001lae.3	+						TCF7L2_uc001lac.3_Intron|TCF7L2_uc010qrk.1_Intron|TCF7L2_uc010qrl.1_Intron|TCF7L2_uc010qrm.1_Intron|TCF7L2_uc010qrn.1_Intron|TCF7L2_uc001lad.3_Intron|TCF7L2_uc001lag.3_Intron|TCF7L2_uc001laf.3_Intron|TCF7L2_uc010qro.1_Intron|TCF7L2_uc001lah.2_Intron|TCF7L2_uc010qrp.1_Intron|TCF7L2_uc010qrq.1_Intron|TCF7L2_uc010qrr.1_Intron|TCF7L2_uc010qrs.1_Intron|TCF7L2_uc010qrt.1_Intron|TCF7L2_uc010qru.1_Intron|TCF7L2_uc010qrv.1_Intron|TCF7L2_uc010qrw.1_Intron|TCF7L2_uc010qrx.1_Intron	NM_001146274	NP_001139746			transcription factor 7-like 2 isoform 1						anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)														---	---	---	---
NRAP	4892	broad.mit.edu	37	10	115351797	115351797	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115351797delT	uc001laj.2	-						NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Intron|NRAP_uc001lal.3_Intron	NM_198060	NP_932326			nebulin-related anchoring protein isoform S							fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	118969993	118969993	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118969993delA								KCNK18 (184 upstream) : SLC18A2 (30723 downstream)																																			---	---	---	---
C10orf90	118611	broad.mit.edu	37	10	128114309	128114309	+	3'UTR	DEL	A	-	-	rs144809692		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128114309delA	uc001ljq.2	-	9					C10orf90_uc001ljp.2_3'UTR|C10orf90_uc010qum.1_3'UTR|C10orf90_uc001ljo.2_RNA	NM_001004298	NP_001004298			hypothetical protein LOC118611											ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)														---	---	---	---
MUC5B	727897	broad.mit.edu	37	11	1274322	1274331	+	Intron	DEL	ATGGTGGGGC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1274322_1274331delATGGTGGGGC	uc009ycr.1	+						MUC5B_uc001ltb.2_Intron	NM_017511	NP_059981			SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;						cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---
TRPM5	29850	broad.mit.edu	37	11	2443237	2443238	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:2443237_2443238insA	uc001lwm.3	-						TRPM5_uc010qxl.1_Intron|TRPM5_uc009ydn.2_Intron	NM_014555	NP_055370			transient receptor potential cation channel,							integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)														---	---	---	---
RIC3	79608	broad.mit.edu	37	11	8160039	8160039	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8160039delA	uc001mgd.2	-						RIC3_uc001mgb.2_5'UTR|RIC3_uc001mgc.2_Intron|RIC3_uc001mge.2_Intron|RIC3_uc010rbl.1_Intron|RIC3_uc010rbm.1_Intron|RIC3_uc009yfm.2_Intron|RIC3_uc009yfn.2_Intron	NM_024557	NP_078833			resistance to inhibitors of cholinesterase 3							endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)														---	---	---	---
TSG101	7251	broad.mit.edu	37	11	18536499	18536499	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18536499delC	uc001mor.2	-						TSG101_uc001mos.1_Intron|TSG101_uc009yhs.1_Intron	NM_006292	NP_006283			tumor susceptibility gene 101						cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0																		---	---	---	---
PRMT3	10196	broad.mit.edu	37	11	20473568	20473569	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20473568_20473569insA	uc001mqb.2	+						PRMT3_uc001mqc.2_Intron|PRMT3_uc010rdn.1_Intron	NM_005788	NP_005779			protein arginine methyltransferase 3 isoform 1								zinc ion binding				0																		---	---	---	---
NELL1	4745	broad.mit.edu	37	11	21595127	21595127	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:21595127delC	uc001mqe.2	+						NELL1_uc001mqf.2_Intron|NELL1_uc009yid.2_Intron|NELL1_uc010rdo.1_Intron|NELL1_uc010rdp.1_Intron|NELL1_uc001mqh.2_Intron	NM_006157	NP_006148			nel-like 1 isoform 1 precursor						cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3																		---	---	---	---
TTC17	55761	broad.mit.edu	37	11	43419441	43419441	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:43419441delT	uc001mxi.2	+						TTC17_uc001mxh.2_Intron|TTC17_uc010rfj.1_Intron|TTC17_uc001mxj.2_Intron	NM_018259	NP_060729			tetratricopeptide repeat domain 17								binding			ovary(5)	5																		---	---	---	---
FNBP4	23360	broad.mit.edu	37	11	47745432	47745434	+	Intron	DEL	TTT	-	-	rs78603297		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47745432_47745434delTTT	uc009ylv.2	-						FNBP4_uc001ngi.2_Intron|FNBP4_uc001ngj.2_Intron	NM_015308	NP_056123			formin binding protein 4											ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	49856398	49856398	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49856398delA								LOC440040 (24431 upstream) : OR4C13 (117577 downstream)																																			---	---	---	---
MS4A4A	51338	broad.mit.edu	37	11	60068559	60068559	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60068559delA	uc001noz.2	+						MS4A4A_uc001npa.2_Intron|MS4A4A_uc001npb.2_Intron|MS4A4A_uc001npc.2_Intron	NM_148975	NP_683876			membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity				0																		---	---	---	---
MS4A7	58475	broad.mit.edu	37	11	60161439	60161439	+	3'UTR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60161439delA	uc001npe.2	+	7					MS4A7_uc001npf.2_3'UTR|MS4A7_uc001npg.2_3'UTR|MS4A7_uc001nph.2_3'UTR|MS4A14_uc001npi.2_Intron	NM_206939	NP_996822			membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CTTN	2017	broad.mit.edu	37	11	70267348	70267349	+	Intron	INS	-	T	T	rs143974083	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70267348_70267349insT	uc001opv.3	+						CTTN_uc001opu.2_Intron|CTTN_uc001opw.3_Intron|CTTN_uc010rqm.1_Intron|CTTN_uc001opx.2_5'Flank	NM_005231	NP_005222			cortactin isoform a							cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)														---	---	---	---
PHOX2A	401	broad.mit.edu	37	11	71952357	71952357	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71952357delG	uc001osh.3	-							NM_005169	NP_005160			paired-like homeobox 2a						noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
RSF1	51773	broad.mit.edu	37	11	77436580	77436580	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77436580delA	uc001oyn.2	-							NM_016578	NP_057662			remodeling and spacing factor 1						CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)															---	---	---	---
INTS4	92105	broad.mit.edu	37	11	77639340	77639340	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77639340delG	uc001oys.2	-						INTS4_uc001oyt.2_Intron|INTS4_uc001oyu.1_Intron	NM_033547	NP_291025			integrator complex subunit 4						snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)															---	---	---	---
PICALM	8301	broad.mit.edu	37	11	85726069	85726069	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:85726069delC	uc001pbm.2	-						PICALM_uc001pbl.2_Intron|PICALM_uc001pbn.2_Intron|PICALM_uc010rtl.1_Intron	NM_007166	NP_009097			phosphatidylinositol-binding clathrin assembly						clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)						T	MLLT10|MLL	TALL|AML|								---	---	---	---
Unknown	0	broad.mit.edu	37	11	97506600	97506601	+	IGR	INS	-	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:97506600_97506601insT								None (None upstream) : None (None downstream)																																			---	---	---	---
KIAA1377	57562	broad.mit.edu	37	11	101832459	101832459	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:101832459delT	uc001pgm.2	+						KIAA1377_uc001pgn.2_Intron|KIAA1377_uc010run.1_Intron|KIAA1377_uc009yxa.1_Intron	NM_020802	NP_065853			hypothetical protein LOC57562								protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)														---	---	---	---
CASP5	838	broad.mit.edu	37	11	104872625	104872626	+	Intron	DEL	AC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:104872625_104872626delAC	uc010rva.1	-						CASP5_uc010ruz.1_Intron|CASP5_uc010rvb.1_Intron|CASP5_uc010rvc.1_Intron|CASP5_uc009yxh.2_Intron|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338			caspase 5 isoform a precursor						apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)														---	---	---	---
KBTBD3	143879	broad.mit.edu	37	11	105929470	105929471	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105929470_105929471delTT	uc001pja.2	-						KBTBD3_uc001pjb.2_Intron|KBTBD3_uc009yxm.2_Intron	NM_198439	NP_940841			BTB and kelch domain containing 3											ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)														---	---	---	---
CUL5	8065	broad.mit.edu	37	11	107949171	107949171	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107949171delA	uc001pjv.2	+						CUL5_uc001pju.2_Intron	NM_003478	NP_003469			Vasopressin-activated calcium-mobilizing						cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)														---	---	---	---
ACAT1	38	broad.mit.edu	37	11	108004840	108004840	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108004840delA	uc001pjy.2	+						ACAT1_uc001pjw.1_Intron|ACAT1_uc001pjx.2_Intron	NM_000019	NP_000010			acetyl-Coenzyme A acetyltransferase 1 precursor						acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)													---	---	---	---
Unknown	0	broad.mit.edu	37	11	109853255	109853255	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:109853255delT								C11orf87 (553417 upstream) : ZC3H12C (110671 downstream)																																			---	---	---	---
PTS	5805	broad.mit.edu	37	11	112100752	112100752	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:112100752delA	uc001pnj.3	+						PTS_uc009yyo.2_Intron	NM_000317	NP_000308			6-pyruvoyltetrahydropterin synthase						cellular amino acid metabolic process|central nervous system development|tetrahydrobiopterin biosynthetic process	mitochondrion	6-pyruvoyltetrahydropterin synthase activity|metal ion binding				0		all_cancers(61;2.51e-14)|all_epithelial(67;1.64e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.27e-06)|BRCA - Breast invasive adenocarcinoma(274;1.43e-06)|all cancers(92;2.1e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0519)														---	---	---	---
NCAM1	4684	broad.mit.edu	37	11	112832392	112832392	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:112832392delT	uc009yyq.1	+						NCAM1_uc001pno.2_Intron|uc001pnn.2_Intron	NM_001076682	NP_001070150			neural cell adhesion molecule 1 isoform 3						axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)														---	---	---	---
SIK3	23387	broad.mit.edu	37	11	116906807	116906807	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116906807delT	uc001ppy.2	-						SIK3_uc001ppz.2_Intron|SIK3_uc001pqa.2_Intron	NM_025164	NP_079440			serine/threonine-protein kinase QSK							cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12																		---	---	---	---
MLL	4297	broad.mit.edu	37	11	118309704	118309704	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118309704delT	uc001pta.2	+						MLL_uc001ptb.2_Intron|MLL_uc001psz.1_Intron	NM_005933	NP_005924			myeloid/lymphoid or mixed-lineage leukemia						apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
GALNT8	26290	broad.mit.edu	37	12	4848291	4848291	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4848291delA	uc001qne.1	+							NM_017417	NP_059113			polypeptide N-acetylgalactosaminyltransferase 8							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
CD163L1	283316	broad.mit.edu	37	12	7556021	7556021	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7556021delT	uc001qsy.2	-						CD163L1_uc010sge.1_Intron	NM_174941	NP_777601			scavenger receptor cysteine-rich type 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11																		---	---	---	---
SLC2A14	144195	broad.mit.edu	37	12	7966767	7966767	+	3'UTR	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7966767delG	uc001qtk.2	-	16					SLC2A14_uc001qtl.2_3'UTR|SLC2A14_uc001qtm.2_3'UTR|SLC2A14_uc010sgg.1_3'UTR|SLC2A14_uc001qtn.2_3'UTR|SLC2A14_uc001qto.2_3'UTR|SLC2A14_uc010sgh.1_3'UTR	NM_153449	NP_703150			glucose transporter 14						cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)														---	---	---	---
PRR4	11272	broad.mit.edu	37	12	11000107	11000107	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:11000107delT	uc001qyz.3	-						PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRR4_uc001qza.3_Intron	NM_007244	NP_009175			proline rich 4 (lacrimal) isoform 2						visual perception	extracellular space					0																		---	---	---	---
PLEKHA5	54477	broad.mit.edu	37	12	19406761	19406761	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:19406761delA	uc001reb.2	+						PLEKHA5_uc010sie.1_Intron|PLEKHA5_uc001rea.2_Intron|PLEKHA5_uc009zin.2_Intron|PLEKHA5_uc010sif.1_Intron|PLEKHA5_uc010sig.1_Intron|PLEKHA5_uc010sih.1_Intron	NM_019012	NP_061885			pleckstrin homology domain containing, family A								1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)																	---	---	---	---
SLC2A13	114134	broad.mit.edu	37	12	40247410	40247410	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40247410delT	uc010skm.1	-						C12orf40_uc009zjv.1_Intron|SLC2A13_uc001rme.1_Intron	NM_052885	NP_443117			solute carrier family 2 (facilitated glucose							integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)													HNSCC(50;0.14)			---	---	---	---
SCN8A	6334	broad.mit.edu	37	12	52056441	52056441	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52056441delT	uc001ryw.2	+							NM_014191	NP_055006			sodium channel, voltage gated, type VIII, alpha						axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)													---	---	---	---
KIF5A	3798	broad.mit.edu	37	12	57975862	57975862	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57975862delA	uc001sor.1	+						KIF5A_uc010srr.1_Intron|uc001sos.2_5'Flank	NM_004984	NP_004975			kinesin family member 5A						blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3																		---	---	---	---
SRGAP1	57522	broad.mit.edu	37	12	64265418	64265418	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64265418delT	uc010ssp.1	+						SRGAP1_uc001srt.2_Intron	NM_020762	NP_065813			SLIT-ROBO Rho GTPase activating protein 1						axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)														---	---	---	---
NUP107	57122	broad.mit.edu	37	12	69126366	69126366	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69126366delA	uc001suf.2	+						NUP107_uc001sug.2_Intron|NUP107_uc010stj.1_Intron	NM_020401	NP_065134			nucleoporin 107kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)															---	---	---	---
Unknown	0	broad.mit.edu	37	12	86175616	86175616	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:86175616delA								ALX1 (480057 upstream) : RASSF9 (22715 downstream)																																			---	---	---	---
ATP2B1	490	broad.mit.edu	37	12	90015715	90015716	+	Intron	INS	-	TT	TT			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:90015715_90015716insTT	uc001tbh.2	-						ATP2B1_uc001tbg.2_Intron|ATP2B1_uc001tbf.2_Intron	NM_001682	NP_001673			plasma membrane calcium ATPase 1 isoform 1b						ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	93429156	93429157	+	IGR	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:93429156_93429157insA								EEA1 (106049 upstream) : NUDT4 (342544 downstream)																																			---	---	---	---
PLXNC1	10154	broad.mit.edu	37	12	94620800	94620800	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94620800delA	uc001tdc.2	+							NM_005761	NP_005752			plexin C1 precursor						axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
TMCC3	57458	broad.mit.edu	37	12	94971958	94971958	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94971958delA	uc001tdj.2	-						TMCC3_uc001tdi.2_Intron	NM_020698	NP_065749			transmembrane and coiled-coil domain family 3							integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
UTP20	27340	broad.mit.edu	37	12	101713543	101713544	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:101713543_101713544delTT	uc001tia.1	+							NM_014503	NP_055318			down-regulated in metastasis						endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4																		---	---	---	---
NUP37	79023	broad.mit.edu	37	12	102479686	102479686	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102479686delA	uc001tjc.2	-						NUP37_uc009zub.1_Intron	NM_024057	NP_076962			nucleoporin 37kDa						carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1																		---	---	---	---
HCFC2	29915	broad.mit.edu	37	12	104476535	104476535	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104476535delA	uc001tkj.3	+	7	1022	c.919delA	c.(919-921)AAAfs	p.K307fs	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	307					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
KIAA1033	23325	broad.mit.edu	37	12	105543321	105543322	+	Intron	INS	-	AATTGATTTG	AATTGATTTG			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105543321_105543322insAATTGATTTG	uc001tld.2	+						KIAA1033_uc010swr.1_Intron|KIAA1033_uc010sws.1_Intron	NM_015275	NP_056090			hypothetical protein LOC23325						endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2																		---	---	---	---
MYO1H	283446	broad.mit.edu	37	12	109858919	109858920	+	Intron	DEL	TT	-	-	rs76061626		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109858919_109858920delTT	uc010sxn.1	+							NM_001101421	NP_001094891			myosin 1H							myosin complex	motor activity				0																		---	---	---	---
MMAB	326625	broad.mit.edu	37	12	110006725	110006726	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110006725_110006726delTT	uc001tou.2	-						MMAB_uc001tov.2_Intron|MMAB_uc001tow.2_Intron|MMAB_uc010sxq.1_Intron|MMAB_uc001tox.2_Intron	NM_052845	NP_443077			cob(I)alamin adenosyltransferase precursor						cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity				0					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
NAA25	80018	broad.mit.edu	37	12	112492462	112492462	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112492462delC	uc001ttm.2	-						NAA25_uc001ttn.3_Intron|NAA25_uc009zvz.1_Intron|NAA25_uc009zwa.1_Intron	NM_024953	NP_079229			mitochondrial distribution and morphology 20							cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
MED13L	23389	broad.mit.edu	37	12	116406919	116406919	+	Intron	DEL	A	-	-	rs35517594		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:116406919delA	uc001tvw.2	-							NM_015335	NP_056150			mediator complex subunit 13-like						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)														---	---	---	---
FBXO21	23014	broad.mit.edu	37	12	117612801	117612802	+	Intron	DEL	AA	-	-	rs138433024		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117612801_117612802delAA	uc001twk.2	-						FBXO21_uc001twj.2_Intron|FBXO21_uc009zwq.2_Intron	NM_033624	NP_296373			F-box only protein 21 isoform 1						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)														---	---	---	---
KSR2	283455	broad.mit.edu	37	12	117965152	117965153	+	Intron	DEL	AG	-	-	rs10545784		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117965152_117965153delAG	uc001two.2	-							NM_173598	NP_775869			kinase suppressor of ras 2						intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
GCN1L1	10985	broad.mit.edu	37	12	120588741	120588742	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120588741_120588742delAA	uc001txo.2	-							NM_006836	NP_006827			GCN1 general control of amino-acid synthesis						regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
SPPL3	121665	broad.mit.edu	37	12	121202941	121202942	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121202941_121202942delAA	uc001tzd.2	-						SPPL3_uc009zwz.2_Intron|SPPL3_uc001tzc.2_Intron	NM_139015	NP_620584			signal peptide peptidase 3							integral to membrane	aspartic-type endopeptidase activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)																	---	---	---	---
KNTC1	9735	broad.mit.edu	37	12	123036082	123036082	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123036082delT	uc001ucv.2	+						KNTC1_uc010taf.1_Intron	NM_014708	NP_055523			Rough Deal homolog, centromere/kinetochore						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)														---	---	---	---
Unknown	0	broad.mit.edu	37	12	124719495	124719497	+	IGR	DEL	CCT	-	-	rs145885629	by1000genomes;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124719495_124719497delCCT								ZNF664 (219528 upstream) : FAM101A (54213 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	12	125396160	125396175	+	IGR	DEL	AAACTTAAAAAAAAAA	-	-	rs68000265		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:125396160_125396175delAAACTTAAAAAAAAAA								SCARB1 (47641 upstream) : UBC (19 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	13	19532389	19532389	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:19532389delT								LOC284232 (86280 upstream) : LOC348021 (50010 downstream)																																			---	---	---	---
PARP4	143	broad.mit.edu	37	13	25069018	25069018	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25069018delT	uc001upl.2	-						PARP4_uc010tdc.1_Intron	NM_006437	NP_006428			poly (ADP-ribose) polymerase family, member 4						cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)														---	---	---	---
STARD13	90627	broad.mit.edu	37	13	33751885	33751887	+	Intron	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33751885_33751887delAAA	uc001uuw.2	-						STARD13_uc001uuu.2_Intron|STARD13_uc001uuv.2_Intron|STARD13_uc001uux.2_Intron|STARD13_uc010tec.1_Intron|STARD13_uc010abh.1_Intron	NM_178006	NP_821074			StAR-related lipid transfer (START) domain						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)														---	---	---	---
FAM48A	55578	broad.mit.edu	37	13	37607341	37607341	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37607341delA	uc001uwg.2	-						FAM48A_uc010abt.2_Intron|FAM48A_uc001uwh.2_Intron|FAM48A_uc001uwi.2_Intron|FAM48A_uc001uwj.2_Intron|FAM48A_uc001uwk.2_Intron|FAM48A_uc010tes.1_Intron|FAM48A_uc001uwl.1_Intron	NM_001014286	NP_001014308			family with sequence similarity 48, member A						autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)														---	---	---	---
COG6	57511	broad.mit.edu	37	13	40256199	40256199	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:40256199delT	uc001uxh.2	+						COG6_uc001uxi.2_Intron|COG6_uc010acb.2_Intron	NM_020751	NP_065802			component of oligomeric golgi complex 6 isoform						protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)														---	---	---	---
CDADC1	81602	broad.mit.edu	37	13	49848636	49848637	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:49848636_49848637delAA	uc001vcu.2	+						CDADC1_uc010tgk.1_Intron|CDADC1_uc001vcv.2_Intron	NM_030911	NP_112173			cytidine and dCMP deaminase domain containing 1								hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)														---	---	---	---
WDFY2	115825	broad.mit.edu	37	13	52325697	52325697	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52325697delT	uc001vfp.2	+						WDFY2_uc010ads.1_3'UTR|WDFY2_uc010adt.1_Intron	NM_052950	NP_443182			WD repeat and FYVE domain containing 2								metal ion binding				0		Breast(56;0.000208)|Lung NSC(96;0.000517)|Prostate(109;0.0041)|Hepatocellular(98;0.0652)|Myeloproliferative disorder(33;0.164)|all_neural(104;0.191)		GBM - Glioblastoma multiforme(99;9e-08)														---	---	---	---
ATP7B	540	broad.mit.edu	37	13	52541371	52541371	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52541371delT	uc001vfw.2	-						ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Intron|ATP7B_uc001vfy.2_Intron|ATP7B_uc010tgt.1_Intron|ATP7B_uc010tgu.1_Intron|ATP7B_uc010tgv.1_Intron|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044			ATPase, Cu++ transporting, beta polypeptide						ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)										Wilson_disease				---	---	---	---
TDRD3	81550	broad.mit.edu	37	13	61057789	61057789	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:61057789delT	uc001via.2	+						TDRD3_uc010aef.2_Intron|TDRD3_uc001vhz.3_Intron|TDRD3_uc010aeg.2_Intron|TDRD3_uc001vib.3_Intron	NM_030794	NP_110421			tudor domain containing 3 isoform 2						chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)														---	---	---	---
GPC6	10082	broad.mit.edu	37	13	94643157	94643158	+	Intron	DEL	GA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:94643157_94643158delGA	uc001vlt.2	+						GPC6_uc010tig.1_Intron	NM_005708	NP_005699			glypican 6 precursor							anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)																---	---	---	---
TNFSF13B	10673	broad.mit.edu	37	13	108955486	108955486	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:108955486delT	uc001vqr.2	+						TNFSF13B_uc010agj.2_Intron|TNFSF13B_uc001vqs.1_Intron	NM_006573	NP_006564			tumor necrosis factor superfamily, member 13b						cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)															---	---	---	---
Unknown	0	broad.mit.edu	37	13	108959365	108959381	+	IGR	DEL	AAAAAAAAAAAAAAAAA	-	-	rs138186115		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:108959365_108959381delAAAAAAAAAAAAAAAAA								TNFSF13B (1 upstream) : MYO16 (289119 downstream)																																			---	---	---	---
COL4A1	1282	broad.mit.edu	37	13	110857594	110857594	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:110857594delT	uc001vqw.3	-						COL4A1_uc010agl.2_Intron	NM_001845	NP_001836			alpha 1 type IV collagen preproprotein						angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)															---	---	---	---
ARHGEF7	8874	broad.mit.edu	37	13	111953300	111953300	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111953300delT	uc010tjo.1	+						ARHGEF7_uc001vrv.3_Intron|ARHGEF7_uc001vrw.3_Intron|ARHGEF7_uc001vrx.3_Intron	NM_003899	NP_003890			PAK-interacting exchange factor beta isoform a						apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)															---	---	---	---
Unknown	0	broad.mit.edu	37	14	19487488	19487488	+	IGR	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:19487488delC								OR11H12 (108916 upstream) : POTEG (65877 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	14	19872018	19872019	+	Intron	INS	-	AGGA	AGGA			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:19872018_19872019insAGGA	uc001vvq.1	-											Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																														---	---	---	---
TEP1	7011	broad.mit.edu	37	14	20874171	20874173	+	Intron	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20874171_20874173delAAA	uc001vxe.2	-						TEP1_uc010tlf.1_Intron|TEP1_uc010tlg.1_Intron	NM_007110	NP_009041			telomerase-associated protein 1						telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)														---	---	---	---
SCFD1	23256	broad.mit.edu	37	14	31144416	31144416	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31144416delT	uc001wqm.1	+						SCFD1_uc001wqn.1_Intron|SCFD1_uc010tpg.1_Intron|SCFD1_uc010tph.1_Intron|SCFD1_uc010amf.1_Intron|SCFD1_uc010tpi.1_Intron|SCFD1_uc010amd.1_Intron|SCFD1_uc010ame.1_Intron	NM_016106	NP_057190			vesicle transport-related protein isoform a						post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)														---	---	---	---
PPP2R3C	55012	broad.mit.edu	37	14	35564160	35564160	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:35564160delA	uc001wss.2	-						PPP2R3C_uc001wst.2_Intron|PPP2R3C_uc010tpr.1_Intron|PPP2R3C_uc001wsu.2_Intron	NM_017917	NP_060387			serine/threonine-protein phosphatase 2A							centrosome|nucleus	calcium ion binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	45330467	45330467	+	IGR	DEL	T	-	-	rs138459383		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45330467delT								FSCB (353968 upstream) : C14orf28 (36040 downstream)																																			---	---	---	---
KTN1	3895	broad.mit.edu	37	14	56150981	56150981	+	3'UTR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:56150981delA	uc001xcb.2	+	46					KTN1_uc001xce.2_3'UTR|KTN1_uc001xcc.2_3'UTR|KTN1_uc001xcd.2_3'UTR|KTN1_uc010trb.1_3'UTR|KTN1_uc010aoq.2_3'UTR|KTN1_uc010trc.1_3'UTR|KTN1_uc001xcg.2_3'UTR	NM_182926	NP_891556			kinectin 1 isoform a						microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7								T	RET	papillary thryoid								---	---	---	---
C14orf37	145407	broad.mit.edu	37	14	58727898	58727899	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58727898_58727899delTT	uc010tro.1	-						PSMA3_uc001xdj.1_Intron|PSMA3_uc001xdk.1_Intron	NM_001001872	NP_001001872			hypothetical protein LOC145407 precursor							integral to membrane	binding				0																		---	---	---	---
MTHFD1	4522	broad.mit.edu	37	14	64867679	64867679	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64867679delT	uc001xhb.2	+						MTHFD1_uc010aqe.2_Intron|MTHFD1_uc010aqf.2_Intron	NM_005956	NP_005947			methylenetetrahydrofolate dehydrogenase 1						folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)													---	---	---	---
C14orf50	145376	broad.mit.edu	37	14	65019694	65019695	+	Intron	DEL	TT	-	-	rs77325213		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65019694_65019695delTT	uc001xhl.1	+							NM_172365	NP_758953			hypothetical protein LOC145376											skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)														---	---	---	---
ZFYVE26	23503	broad.mit.edu	37	14	68244576	68244576	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68244576delT	uc001xka.2	-						ZFYVE26_uc010tsz.1_Intron|ZFYVE26_uc001xkc.3_Intron	NM_015346	NP_056161			zinc finger, FYVE domain containing 26						cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)														---	---	---	---
PCNX	22990	broad.mit.edu	37	14	71476536	71476536	+	Intron	DEL	T	-	-	rs34870105		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:71476536delT	uc001xmo.2	+						PCNX_uc001xmn.3_Intron|PCNX_uc010are.1_Intron	NM_014982	NP_055797			pecanex-like 1							integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)														---	---	---	---
EIF2B2	8892	broad.mit.edu	37	14	75476005	75476005	+	3'UTR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75476005delA	uc001xrc.1	+	8						NM_014239	NP_055054			eukaryotic translation initiation factor 2B,						cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)														---	---	---	---
VASH1	22846	broad.mit.edu	37	14	77229171	77229171	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77229171delG	uc001xst.2	+	1	937	c.7delG	c.(7-9)GGGfs	p.G3fs	VASH1_uc001xss.2_Frame_Shift_Del_p.G3fs	NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	3					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)														---	---	---	---
DICER1	23405	broad.mit.edu	37	14	95581843	95581844	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95581843_95581844insA	uc001ydw.2	-						DICER1_uc001ydv.2_Intron|DICER1_uc001ydx.2_Intron	NM_030621	NP_085124			dicer1						negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)				Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				---	---	---	---
PAPOLA	10914	broad.mit.edu	37	14	96991497	96991497	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96991497delT	uc001yfq.2	+						PAPOLA_uc001yfo.2_Intron|PAPOLA_uc001yfp.2_Intron|PAPOLA_uc001yfr.2_Intron|PAPOLA_uc010twv.1_Intron|PAPOLA_uc010avp.2_Intron	NM_032632	NP_116021			poly(A) polymerase alpha						mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)														---	---	---	---
CCNK	8812	broad.mit.edu	37	14	99968522	99968522	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:99968522delT	uc001ygi.3	+						CCNK_uc001ygg.3_Intron	NM_001099402	NP_001092872			cyclin K isoform 1						cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)																---	---	---	---
RCOR1	23186	broad.mit.edu	37	14	103192668	103192668	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103192668delA	uc001ymb.2	+							NM_015156	NP_055971			REST corepressor 1						blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1																		---	---	---	---
MTA1	9112	broad.mit.edu	37	14	105905492	105905493	+	Intron	INS	-	T	T	rs140601392	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105905492_105905493insT	uc001yqx.2	+						MTA1_uc001yqy.2_Intron|MTA1_uc001yqz.1_Intron|MTA1_uc001yra.1_Intron	NM_004689	NP_004680			metastasis associated protein						signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	20263577	20263578	+	IGR	INS	-	A	A	rs58110116		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:20263577_20263578insA								None (None upstream) : GOLGA6L6 (473516 downstream)																																			---	---	---	---
CYFIP1	23191	broad.mit.edu	37	15	22980298	22980298	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22980298delT	uc001yus.2	+						CYFIP1_uc001yut.2_Intron|CYFIP1_uc010aya.1_Intron|CYFIP1_uc001yuu.2_Intron|CYFIP1_uc001yuv.2_Intron	NM_014608	NP_055423			cytoplasmic FMR1 interacting protein 1 isoform						axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	28913367	28913367	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28913367delT	uc010azc.2	+						uc010uao.1_Intron					Homo sapiens I.M.A.G.E. clone 321824, mRNA sequence.																														---	---	---	---
TRPM1	4308	broad.mit.edu	37	15	31293996	31293997	+	3'UTR	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31293996_31293997delAA	uc001zfm.2	-	27					TRPM1_uc010azy.2_3'UTR|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411			transient receptor potential cation channel,						cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)														---	---	---	---
FMN1	342184	broad.mit.edu	37	15	33180571	33180571	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33180571delA	uc001zhf.3	-							NM_001103184	NP_001096654			formin 1						actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)														---	---	---	---
NUSAP1	51203	broad.mit.edu	37	15	41657842	41657842	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41657842delA	uc001zns.3	+						NUSAP1_uc001znq.3_Intron|NUSAP1_uc001znr.3_Intron|NUSAP1_uc010bce.2_Intron|NUSAP1_uc001znt.3_Intron|NUSAP1_uc001znv.3_Intron|NUSAP1_uc001znu.3_Intron|NUSAP1_uc010ucw.1_Intron|NUSAP1_uc001znw.3_Intron	NM_016359	NP_057443			nucleolar and spindle associated protein 1						cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)														---	---	---	---
TMOD3	29766	broad.mit.edu	37	15	52200810	52200813	+	Intron	DEL	TTTT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52200810_52200813delTTTT	uc002abm.2	+						TMOD3_uc010bfc.1_Intron|TMOD3_uc002abn.2_5'Flank	NM_014547	NP_055362			tropomodulin 3 (ubiquitous)							cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1				all cancers(107;0.00194)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54915983	54915983	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54915983delT	uc002ack.2	+						UNC13C_uc002acm.2_Intron	NM_001080534	NP_001074003			unc-13 homolog C						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
VPS13C	54832	broad.mit.edu	37	15	62333412	62333412	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62333412delA	uc002agz.2	-						VPS13C_uc002aha.2_Intron|VPS13C_uc002ahb.1_Intron|VPS13C_uc002ahc.1_Intron	NM_020821	NP_065872			vacuolar protein sorting 13C protein isoform 2A						protein localization					ovary(2)	2																		---	---	---	---
HERC1	8925	broad.mit.edu	37	15	64015557	64015557	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64015557delA	uc002amp.2	-						HERC1_uc010uil.1_Intron	NM_003922	NP_003913			hect domain and RCC1-like domain 1						protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19																		---	---	---	---
TRIP4	9325	broad.mit.edu	37	15	64686385	64686385	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64686385delT	uc002anm.2	+							NM_016213	NP_057297			thyroid hormone receptor interactor 4						positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	65989151	65989151	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65989151delT	uc002aph.2	-						DENND4A_uc002api.2_Intron|DENND4A_uc002apj.3_Intron	NM_005848	NP_005839			DENN/MADD domain containing 4A isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	66048464	66048464	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66048464delA	uc002aph.2	-						DENND4A_uc002api.2_Intron|DENND4A_uc002apj.3_Intron|DENND4A_uc010ujj.1_Intron	NM_005848	NP_005839			DENN/MADD domain containing 4A isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
THSD4	79875	broad.mit.edu	37	15	72041049	72041049	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72041049delA	uc002atb.1	+						THSD4_uc002ate.2_Intron	NM_024817	NP_079093			thrombospondin, type I, domain containing 4							proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2																		---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72208543	72208543	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72208543delT	uc002atl.3	-						MYO9A_uc010biq.2_Intron|MYO9A_uc002atn.1_Intron	NM_006901	NP_008832			myosin IXA						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75722399	75722399	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75722399delT	uc002bai.2	-						SIN3A_uc002baj.2_Intron|SIN3A_uc010uml.1_Intron|SIN3A_uc002bak.3_Intron	NM_015477	NP_056292			transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
FANCI	55215	broad.mit.edu	37	15	89833279	89833279	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89833279delA	uc010bnp.1	+						FANCI_uc002bnm.1_Intron|FANCI_uc002bnn.1_Intron|FANCI_uc002bnp.1_Intron|FANCI_uc002bnq.1_Intron	NM_001113378	NP_001106849			Fanconi anemia, complementation group I isoform						cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)												Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
SELS	55829	broad.mit.edu	37	15	101816620	101816620	+	Intron	DEL	T	-	-	rs66734613		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101816620delT	uc010use.1	-						SELS_uc010usf.1_Intron	NM_203472	NP_982298			selenoprotein S						anti-apoptosis|cell redox homeostasis|cellular response to insulin stimulus|cellular response to lipopolysaccharide|cellular response to oxidative stress|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|negative regulation of acute inflammatory response to antigenic stimulus|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of interleukin-6 production|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of tumor necrosis factor production|regulation of gluconeogenesis|regulation of nitric oxide metabolic process|response to glucose stimulus|response to redox state|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane|low-density lipoprotein particle|microsome|plasma membrane|very-low-density lipoprotein particle	antioxidant activity|enzyme binding|receptor activity|selenium binding				0	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
SOLH	6650	broad.mit.edu	37	16	597450	597450	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:597450delC	uc002chi.2	+	4	975	c.612delC	c.(610-612)CTCfs	p.L204fs	SOLH_uc002chh.1_Frame_Shift_Del_p.L204fs	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	204					proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)																---	---	---	---
SRRM2	23524	broad.mit.edu	37	16	2806346	2806346	+	5'UTR	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2806346delC	uc002crk.2	+	2					SRRM2_uc002crj.1_Intron|SRRM2_uc002crl.1_5'UTR|SRRM2_uc010bsu.1_Intron	NM_016333	NP_057417			splicing coactivator subunit SRm300							Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
CLUAP1	23059	broad.mit.edu	37	16	3569691	3569691	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3569691delA	uc002cvk.1	+						CLUAP1_uc002cvj.1_Intron|CLUAP1_uc002cvl.1_Intron|CLUAP1_uc002cvm.1_Intron	NM_015041	NP_055856			clusterin associated protein 1 isoform 1							nucleus	protein binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
PPL	5493	broad.mit.edu	37	16	4952694	4952694	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4952694delT	uc002cyd.1	-							NM_002705	NP_002696			periplakin						keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
RSL1D1	26156	broad.mit.edu	37	16	11940252	11940252	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11940252delA	uc002dbp.1	-						RSL1D1_uc010buv.1_Intron|RSL1D1_uc010uyw.1_Intron|RSL1D1_uc010buw.2_Intron	NM_015659	NP_056474			ribosomal L1 domain containing 1						regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0																		---	---	---	---
PARN	5073	broad.mit.edu	37	16	14649645	14649646	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14649645_14649646insA	uc010uzd.1	-						PARN_uc010uzc.1_Intron|PARN_uc010uze.1_Intron|PARN_uc010uzf.1_Intron	NM_002582	NP_002573			poly(A)-specific ribonuclease (deadenylation						female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2																		---	---	---	---
ABCC1	4363	broad.mit.edu	37	16	16138681	16138682	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:16138681_16138682insA	uc010bvi.2	+						ABCC1_uc010bvj.2_Intron|ABCC1_uc010bvk.2_Intron|ABCC1_uc010bvl.2_Intron|ABCC1_uc010bvm.2_Intron|ABCC1_uc002del.3_Intron|ABCC1_uc010bvn.2_Intron	NM_004996	NP_004987			ATP-binding cassette, sub-family C, member 1						hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)													---	---	---	---
Unknown	0	broad.mit.edu	37	16	21469994	21469994	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21469994delA	uc002diq.3	+						LOC100271836_uc002diu.1_Intron|LOC100271836_uc002diz.1_5'Flank					Homo sapiens cDNA FLJ59829 complete cds.																														---	---	---	---
ARHGAP17	55114	broad.mit.edu	37	16	24960607	24960607	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24960607delT	uc002dnb.2	-						ARHGAP17_uc002dna.2_Intron|ARHGAP17_uc002dnc.2_Intron|ARHGAP17_uc010vcf.1_Intron|ARHGAP17_uc002dnf.2_3'UTR	NM_001006634	NP_001006635			nadrin isoform 1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)														---	---	---	---
LOC595101	595101	broad.mit.edu	37	16	30291742	30291742	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30291742delA	uc002dxp.1	-							NR_002453				Homo sapiens cDNA FLJ39663 fis, clone SMINT2007187.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	32198251	32198251	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:32198251delA	uc010vfv.1	-											Homo sapiens cDNA FLJ60890 complete cds, moderately similar to HECT domain and RCC1-like domain-containing protein 2.																														---	---	---	---
ITFG1	81533	broad.mit.edu	37	16	47292700	47292700	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47292700delA	uc002eet.2	-						ITFG1_uc010vgg.1_Intron|ITFG1_uc010vgh.1_Intron	NM_030790	NP_110417			integrin alpha FG-GAP repeat containing 1							extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)																---	---	---	---
OGFOD1	55239	broad.mit.edu	37	16	56501343	56501345	+	Intron	DEL	TTT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56501343_56501345delTTT	uc002ejb.2	+						OGFOD1_uc002ejc.2_Intron	NM_018233	NP_060703			2-oxoglutarate and iron-dependent oxygenase								iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)													---	---	---	---
HERPUD1	9709	broad.mit.edu	37	16	56970953	56970953	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56970953delA	uc002eke.1	+						HERPUD1_uc010vhj.1_3'UTR|HERPUD1_uc002ekf.1_Intron|HERPUD1_uc002ekg.1_Intron|HERPUD1_uc010cco.1_Intron|HERPUD1_uc010ccp.1_Intron|HERPUD1_uc002ekh.1_Intron	NM_014685	NP_055500			homocysteine-inducible, endoplasmic reticulum							endoplasmic reticulum membrane|integral to membrane	protein binding				0								T	ERG	prostate								---	---	---	---
C16orf57	79650	broad.mit.edu	37	16	58048101	58048101	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58048101delT	uc002emz.2	+						C16orf57_uc010vib.1_Intron	NM_024598	NP_078874			hypothetical protein LOC79650												0																		---	---	---	---
NDRG4	65009	broad.mit.edu	37	16	58529013	58529013	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58529013delC	uc002enm.2	+						NDRG4_uc002enk.2_Intron|NDRG4_uc010vif.1_Intron	NM_001130487	NP_001123959			NDRG family member 4 isoform 2						cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1																		---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58580742	58580742	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58580742delG	uc002env.2	-						CNOT1_uc002enw.2_Intron|CNOT1_uc002enu.3_Intron|CNOT1_uc002enx.2_Intron|CNOT1_uc010vik.1_Intron	NM_016284	NP_057368			CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
KCTD19	146212	broad.mit.edu	37	16	67325776	67325776	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67325776delA	uc002esu.2	-						KCTD19_uc002est.2_Intron|KCTD19_uc010vjj.1_Intron	NM_001100915	NP_001094385			potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)														---	---	---	---
IL34	146433	broad.mit.edu	37	16	70690422	70690422	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70690422delA	uc002ezh.1	+						IL34_uc002ezi.1_Intron	NM_152456	NP_689669			interleukin 34 precursor						positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
MTSS1L	92154	broad.mit.edu	37	16	70710944	70710944	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70710944delC	uc002ezj.2	-						MTSS1L_uc002ezk.1_Intron	NM_138383	NP_612392			metastasis suppressor 1-like						filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1																		---	---	---	---
KIAA0174	9798	broad.mit.edu	37	16	71949731	71949731	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71949731delT	uc002fbj.1	+						KIAA0174_uc010cgh.1_Intron|KIAA0174_uc002fbk.1_Intron|KIAA0174_uc002fbm.1_Intron|KIAA0174_uc002fbl.1_Intron|KIAA0174_uc002fbn.1_Intron|KIAA0174_uc010cgi.1_Intron|KIAA0174_uc010cgj.1_5'Flank|KIAA0174_uc010vmk.1_Intron					SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;						cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1																		---	---	---	---
FA2H	79152	broad.mit.edu	37	16	74774218	74774218	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:74774218delA	uc002fde.1	-						FA2H_uc010vmy.1_Intron	NM_024306	NP_077282			fatty acid 2-hydroxylase						cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0																		---	---	---	---
C16orf46	123775	broad.mit.edu	37	16	81087883	81087886	+	Intron	DEL	CAAC	-	-	rs62054595	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81087883_81087886delCAAC	uc010chf.2	-							NM_001100873	NP_001094343			chromosome 16 open reading frame 46 isoform 1												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	81759344	81759344	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81759344delT								CMIP (13979 upstream) : PLCG2 (53586 downstream)																																			---	---	---	---
ANKRD11	29123	broad.mit.edu	37	16	89337131	89337131	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89337131delC	uc002fmx.1	-						ANKRD11_uc002fmy.1_Intron|uc002fmz.1_RNA	NM_013275	NP_037407			ankyrin repeat domain 11							nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)														---	---	---	---
SLC43A2	124935	broad.mit.edu	37	17	1480158	1480163	+	Intron	DEL	TTTTTT	-	-	rs149169069		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1480158_1480163delTTTTTT	uc002fsv.2	-						SLC43A2_uc002fsu.2_Intron	NM_152346	NP_689559			solute carrier family 43, member 2						cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)														---	---	---	---
SCARF1	8578	broad.mit.edu	37	17	1539906	1539906	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1539906delA	uc002fsz.1	-						SCARF1_uc002fsy.1_Intron|SCARF1_uc002fta.1_Intron|SCARF1_uc010cjv.1_Intron	NM_003693	NP_003684			scavenger receptor class F, member 1 isoform 1						cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
SMTNL2	342527	broad.mit.edu	37	17	4510381	4510381	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4510381delA	uc002fyf.1	+						SMTNL2_uc002fye.2_Intron	NM_001114974	NP_001108446			smoothelin-like 2 isoform 1												0				READ - Rectum adenocarcinoma(115;0.0325)														---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7658285	7658285	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7658285delA	uc002giu.1	+							NM_020877	NP_065928			dynein heavy chain domain 3						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
STX8	9482	broad.mit.edu	37	17	9282137	9282137	+	Intron	DEL	A	-	-	rs139246965	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9282137delA	uc002glx.2	-							NM_004853	NP_004844			syntaxin 8						transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1																		---	---	---	---
STX8	9482	broad.mit.edu	37	17	9471827	9471827	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9471827delT	uc002glx.2	-							NM_004853	NP_004844			syntaxin 8						transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1																		---	---	---	---
MYH1	4619	broad.mit.edu	37	17	10406731	10406731	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10406731delA	uc002gmo.2	-						uc002gml.1_Intron	NM_005963	NP_005954			myosin, heavy chain 1, skeletal muscle, adult							muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21																		---	---	---	---
MYH2	4620	broad.mit.edu	37	17	10424898	10424899	+	Intron	DEL	AT	-	-	rs147245930		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10424898_10424899delAT	uc010coi.2	-						uc002gml.1_Intron|MYH2_uc002gmp.3_Intron|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582			myosin heavy chain IIa						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14																		---	---	---	---
ELAC2	60528	broad.mit.edu	37	17	12909387	12909387	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12909387delA	uc002gnz.3	-						ELAC2_uc002gnv.3_5'Flank|ELAC2_uc002gnw.3_5'Flank|ELAC2_uc002gnx.3_5'UTR|ELAC2_uc010vvo.1_Intron|ELAC2_uc010vvp.1_Intron|ELAC2_uc010vvq.1_Intron|ELAC2_uc010vvr.1_Intron	NM_018127	NP_060597			elaC homolog 2 isoform 1						tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0														Hereditary_Prostate_Cancer				---	---	---	---
NCOR1	9611	broad.mit.edu	37	17	15948314	15948315	+	Intron	DEL	AA	-	-	rs112069615		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15948314_15948315delAA	uc002gpo.2	-						NCOR1_uc002gpn.2_Intron|NCOR1_uc002gpl.2_Intron|NCOR1_uc002gpm.2_Intron|NCOR1_uc010vwb.1_Intron|NCOR1_uc010coy.2_Intron	NM_006311	NP_006302			nuclear receptor co-repressor 1						cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)														---	---	---	---
CCDC144B	284047	broad.mit.edu	37	17	18498258	18498258	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18498258delT	uc002gub.1	-						CCDC144B_uc002gua.3_Intron|CCDC144B_uc010vyc.1_Intron	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	18988562	18988562	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18988562delT								GRAP (38226 upstream) : GRAPL (42220 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	17	20319292	20319292	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20319292delA	uc010vzg.1	+						uc002gwx.2_5'Flank					Homo sapiens cDNA FLJ59693 complete cds, moderately similar to Ankyrin repeat domain-containing protein 26.																														---	---	---	---
PHF12	57649	broad.mit.edu	37	17	27237974	27237974	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27237974delC	uc002hdg.1	-						PHF12_uc010wbb.1_Intron|PHF12_uc002hdi.1_Intron|PHF12_uc002hdh.1_Intron	NM_001033561	NP_001028733			PHD finger protein 12 isoform 1						negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)															---	---	---	---
RHOT1	55288	broad.mit.edu	37	17	30477376	30477376	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30477376delT	uc002hgz.2	+						RHOT1_uc002hgw.2_Intron|RHOT1_uc002hgy.2_Intron|RHOT1_uc002hha.2_Intron|RHOT1_uc010csv.2_Intron|RHOT1_uc002hgx.2_Intron|RHOT1_uc010wby.1_Intron|RHOT1_uc002hhb.2_Intron|RHOT1_uc002hgv.2_Intron	NM_018307	NP_060777			ras homolog gene family, member T1 isoform 3						apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)																---	---	---	---
C17orf75	64149	broad.mit.edu	37	17	30666605	30666606	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30666605_30666606insA	uc002hhg.2	-							NM_022344	NP_071739			hypothetical protein LOC64149						spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)															---	---	---	---
TMEM132E	124842	broad.mit.edu	37	17	32965285	32965286	+	3'UTR	INS	-	CA	CA	rs28442132	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:32965285_32965286insCA	uc002hif.2	+	10						NM_207313	NP_997196			transmembrane protein 132E precursor							integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)												OREG0024325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GGNBP2	79893	broad.mit.edu	37	17	34942126	34942126	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34942126delA	uc002hnb.2	+						GGNBP2_uc002hna.2_3'UTR|GGNBP2_uc002hnc.1_Intron	NM_024835	NP_079111			zinc finger protein 403						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)														---	---	---	---
MRPL45	84311	broad.mit.edu	37	17	36476863	36476863	+	Intron	DEL	T	-	-	rs67792707		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36476863delT	uc002hpy.2	+							NM_032351	NP_115727			mitochondrial ribosomal protein L45 precursor						intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome				0	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)																---	---	---	---
TOP2A	7153	broad.mit.edu	37	17	38562532	38562532	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38562532delT	uc002huq.2	-							NM_001067	NP_001058			DNA topoisomerase II, alpha isozyme						apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)													---	---	---	---
AARSD1	80755	broad.mit.edu	37	17	41102792	41102792	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41102792delA	uc002icc.2	-						AARSD1_uc002icd.2_Intron|AARSD1_uc002ice.2_Intron|AARSD1_uc002icf.2_Intron|AARSD1_uc010whg.1_Intron	NM_025267	NP_079543			alanyl-tRNA synthetase domain containing 1						alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)														---	---	---	---
RPL27	6155	broad.mit.edu	37	17	41154524	41154524	+	Intron	DEL	A	-	-	rs76067241		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41154524delA	uc002icj.2	+						RPL27_uc002ick.2_Intron	NM_000988	NP_000979			ribosomal protein L27						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	structural constituent of ribosome				0		Breast(137;0.000717)|Ovarian(249;0.0776)		BRCA - Breast invasive adenocarcinoma(366;0.157)														---	---	---	---
EFTUD2	9343	broad.mit.edu	37	17	42945542	42945545	+	Intron	DEL	AAAA	-	-	rs72382060		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42945542_42945545delAAAA	uc002ihn.2	-						EFTUD2_uc010wje.1_Intron|EFTUD2_uc010wjf.1_Intron	NM_004247	NP_004238			elongation factor Tu GTP binding domain							Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)																---	---	---	---
Unknown	0	broad.mit.edu	37	17	45128651	45128652	+	5'Flank	INS	-	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45128651_45128652insT	uc010wkl.1	-						uc010wkm.1_3'UTR					Homo sapiens cDNA FLJ38031 fis, clone CTONG2013348.																														---	---	---	---
ITGB3	3690	broad.mit.edu	37	17	45370099	45370099	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45370099delA	uc002ilj.2	+						ITGB3_uc010wkr.1_Intron	NM_000212	NP_000203			integrin beta chain, beta 3 precursor						activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)													---	---	---	---
ITGB3	3690	broad.mit.edu	37	17	45377702	45377703	+	Intron	INS	-	GCGT	GCGT	rs72300893		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45377702_45377703insGCGT	uc002ilj.2	+						ITGB3_uc010wkr.1_Intron	NM_000212	NP_000203			integrin beta chain, beta 3 precursor						activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)													---	---	---	---
KPNB1	3837	broad.mit.edu	37	17	45741352	45741353	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45741352_45741353delAA	uc002ilt.1	+						KPNB1_uc010wkw.1_Intron|KPNB1_uc010wkx.1_Intron	NM_002265	NP_002256			karyopherin beta 1						DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
MYCBPAP	84073	broad.mit.edu	37	17	48593820	48593821	+	Intron	INS	-	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48593820_48593821insC	uc010wmr.1	+						MYCBPAP_uc002iqx.2_Intron|MYCBPAP_uc002iqz.2_Intron	NM_032133	NP_115509			Myc-binding protein-associated protein						cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)															---	---	---	---
TMEM49	81671	broad.mit.edu	37	17	57886365	57886365	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57886365delT	uc002ixu.3	+						TMEM49_uc010wog.1_Intron|TMEM49_uc010woh.1_Intron|TMEM49_uc010woi.1_Intron|TMEM49_uc010woj.1_Intron	NM_030938	NP_112200			transmembrane protein 49						autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane					0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;1.15e-09)|all cancers(12;1.15e-08)															---	---	---	---
LOC146880	146880	broad.mit.edu	37	17	62750914	62750914	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62750914delT	uc010wqc.1	-							NR_026899				Homo sapiens cDNA FLJ30780 fis, clone FEBRA2000856.												0																		---	---	---	---
CCDC46	201134	broad.mit.edu	37	17	64025820	64025821	+	Intron	INS	-	TAAA	TAAA	rs144628903	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64025820_64025821insTAAA	uc002jfl.2	-						CCDC46_uc010deo.2_Intron|CCDC46_uc002jfm.2_Intron|CCDC46_uc010dep.2_Intron	NM_145036	NP_659473			coiled-coil domain containing 46 isoform a							centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)															---	---	---	---
PRKAR1A	5573	broad.mit.edu	37	17	66520326	66520326	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66520326delT	uc002jhg.2	+						PRKAR1A_uc002jhh.2_Intron|PRKAR1A_uc002jhi.2_Intron|PRKAR1A_uc002jhj.2_Intron|PRKAR1A_uc002jhk.2_Intron|PRKAR1A_uc002jhl.2_Intron|PRKAR1A_uc002jhm.2_Intron	NM_212471	NP_997636			cAMP-dependent protein kinase, regulatory						activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|lung(3)|thyroid(2)|soft_tissue(2)|breast(1)	12	Breast(10;1.64e-13)							T|Mis|N|F|S	RET	papillary thyroid	myxoma|endocrine|papillary thyroid			Carney_Complex|Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial|Cardiac_Myxomas_Familial_Clustering_of				---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67197935	67197935	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67197935delT	uc010dfa.1	-						ABCA10_uc010wqt.1_Intron|ABCA10_uc010dfb.1_Intron|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021			ATP-binding cassette, sub-family A, member 10						transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
MAP2K6	5608	broad.mit.edu	37	17	67487297	67487297	+	Intron	DEL	T	-	-	rs12938052		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67487297delT	uc002jij.2	+						MAP2K6_uc002jii.2_Intron	NM_002758	NP_002749			mitogen-activated protein kinase kinase 6						activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)																	---	---	---	---
NOTUM	147111	broad.mit.edu	37	17	79911207	79911207	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79911207delT	uc010wvg.1	-							NM_178493	NP_848588			notum pectinacetylesterase homolog precursor							extracellular region	hydrolase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)															---	---	---	---
L3MBTL4	91133	broad.mit.edu	37	18	6322510	6322510	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:6322510delA	uc002kmz.3	-						L3MBTL4_uc010dkt.2_Intron	NM_173464	NP_775735			l(3)mbt-like 4						chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)																---	---	---	---
Unknown	0	broad.mit.edu	37	18	11929037	11929037	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:11929037delT								MPPE1 (20396 upstream) : IMPA2 (52020 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	18	15198397	15198399	+	IGR	DEL	AAA	-	-	rs34382864		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:15198397_15198399delAAA								ANKRD30B (345660 upstream) : LOC644669 (115156 downstream)																																			---	---	---	---
C18orf45	85019	broad.mit.edu	37	18	20889480	20889481	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:20889480_20889481delTT	uc002kuf.2	-						C18orf45_uc010xaq.1_Intron|C18orf45_uc010xar.1_Intron|C18orf45_uc002kug.2_Intron|C18orf45_uc002kuh.2_Intron|C18orf45_uc002kue.2_Intron	NM_032933	NP_116322			hypothetical protein LOC85019							integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)																	---	---	---	---
KIAA1012	22878	broad.mit.edu	37	18	29489050	29489050	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29489050delA	uc002kxc.3	-						KIAA1012_uc002kxb.3_Intron|KIAA1012_uc002kxd.3_Intron|KIAA1012_uc002kxe.2_Intron	NM_014939	NP_055754			hypothetical protein LOC22878						ER to Golgi vesicle-mediated transport	cis-Golgi network					0																		---	---	---	---
TXNL1	9352	broad.mit.edu	37	18	54283634	54283634	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54283634delA	uc002lgg.2	-						TXNL1_uc010xdz.1_Intron|TXNL1_uc002lgh.2_Intron|TXNL1_uc002lgi.2_Intron|TXNL1_uc002lgj.1_Intron	NM_004786	NP_004777			thioredoxin-like 1						cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)														---	---	---	---
Unknown	0	broad.mit.edu	37	18	65042307	65042307	+	IGR	DEL	T	-	-	rs75002100		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:65042307delT								CDH19 (771091 upstream) : DSEL (131512 downstream)																																			---	---	---	---
ATP9B	374868	broad.mit.edu	37	18	77089431	77089432	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77089431_77089432delTT	uc002lmx.2	+						ATP9B_uc002lmw.1_Intron|ATP9B_uc002lmz.1_Intron	NM_198531	NP_940933			ATPase, class II, type 9B						ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)														---	---	---	---
ZNF556	80032	broad.mit.edu	37	19	2877213	2877213	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2877213delA	uc002lwp.1	+						ZNF556_uc002lwq.2_Intron	NM_024967	NP_079243			zinc finger protein 556						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
TMEM146	257062	broad.mit.edu	37	19	5733772	5733772	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5733772delT	uc002mda.2	+						TMEM146_uc010duj.1_Intron	NM_152784	NP_689997			transmembrane protein 146 precursor							integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
ZNF699	374879	broad.mit.edu	37	19	9415943	9415944	+	5'Flank	DEL	AC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9415943_9415944delAC	uc002mlc.1	-							NM_198535	NP_940937			zinc finger protein 699						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ATG4D	84971	broad.mit.edu	37	19	10662661	10662661	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10662661delC	uc002mov.2	+						ATG4D_uc010xlh.1_Intron|ATG4D_uc010dxh.2_Intron|ATG4D_uc010dxi.2_Intron|ATG4D_uc010dxj.2_Intron|MIR1238_hsa-mir-1238|MI0006328_5'Flank	NM_032885	NP_116274			APG4 autophagy 4 homolog D						autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)															---	---	---	---
RGL3	57139	broad.mit.edu	37	19	11527830	11527832	+	Intron	DEL	TTG	-	-	rs160523		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11527830_11527832delTTG	uc002mrp.2	-						RGL3_uc002mrn.2_Intron|RGL3_uc002mrm.2_Intron|RGL3_uc002mro.2_Intron|RGL3_uc002mrq.2_Intron	NM_001035223	NP_001030300			ral guanine nucleotide dissociation						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1																		---	---	---	---
RNASEH2A	10535	broad.mit.edu	37	19	12923822	12923822	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12923822delA	uc002mvg.1	+						RNASEH2A_uc002mvf.1_Intron	NM_006397	NP_006388			ribonuclease H2, large subunit						DNA replication|RNA catabolic process	nucleus|ribonuclease H2 complex	metal ion binding|ribonuclease H activity|RNA binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
FARSA	2193	broad.mit.edu	37	19	13036039	13036039	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13036039delT	uc002mvs.2	-						FARSA_uc002mvt.2_Intron|FARSA_uc010xmv.1_Intron|FARSA_uc010dyy.1_Intron	NM_004461	NP_004452			phenylalanyl-tRNA synthetase, alpha subunit						phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)													---	---	---	---
DDX39	10212	broad.mit.edu	37	19	14521311	14521311	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14521311delG	uc010xnp.1	-						DDX39_uc002myo.2_Intron|DDX39_uc010dzl.2_Intron|DDX39_uc010dzm.1_Intron	NM_005804	NP_005795			DEAD (Asp-Glu-Ala-Asp) box polypeptide 39						mRNA export from nucleus|nuclear mRNA splicing, via spliceosome	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding				0																		---	---	---	---
GIPC1	10755	broad.mit.edu	37	19	14590164	14590165	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14590164_14590165insA	uc002myt.2	-						GIPC1_uc002myu.2_Intron|GIPC1_uc002myv.2_Intron|GIPC1_uc002myw.2_Intron|GIPC1_uc002myx.2_Intron|GIPC1_uc002myy.2_Intron	NM_005716	NP_005707			regulator of G-protein signalling 19 interacting						endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0																		---	---	---	---
CALR3	125972	broad.mit.edu	37	19	16596143	16596143	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16596143delT	uc002ned.2	-						MED26_uc002nee.2_Intron	NM_145046	NP_659483			calreticulin 3 precursor						protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding				0																		---	---	---	---
NWD1	284434	broad.mit.edu	37	19	16872616	16872616	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16872616delA	uc002neu.3	+						NWD1_uc002net.3_Intron|NWD1_uc002nev.3_Intron					RecName: Full=NACHT and WD repeat domain-containing protein 1;								ATP binding			skin(3)|ovary(2)|pancreas(2)	7																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17750846	17750846	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17750846delT	uc002nhd.2	-							NM_001080421	NP_001073890			unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17753825	17753826	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17753825_17753826delTT	uc002nhd.2	-							NM_001080421	NP_001073890			unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
HAPLN4	404037	broad.mit.edu	37	19	19379018	19379018	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19379018delT	uc002nmc.2	-						TM6SF2_uc002nmd.1_Intron	NM_023002	NP_075378			hyaluronan and proteoglycan link protein 4						cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)															---	---	---	---
Unknown	0	broad.mit.edu	37	19	21021321	21021321	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21021321delT								ZNF626 (176919 upstream) : ZNF85 (84759 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	21469726	21469726	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21469726delT								ZNF431 (100921 upstream) : ZNF708 (4237 downstream)																																			---	---	---	---
HNRNPUL1	11100	broad.mit.edu	37	19	41797899	41797900	+	Intron	INS	-	A	A	rs66916970		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41797899_41797900insA	uc002oqb.3	+						CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Intron|HNRNPUL1_uc002oqa.3_Intron|HNRNPUL1_uc010ehm.2_Intron|HNRNPUL1_uc002oqc.3_Intron|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Intron|HNRNPUL1_uc010ehn.2_Intron|HNRNPUL1_uc010eho.2_Intron|HNRNPUL1_uc010xvy.1_Intron|HNRNPUL1_uc010ehp.2_Intron|HNRNPUL1_uc010ehl.1_Intron	NM_007040	NP_008971			heterogeneous nuclear ribonucleoprotein U-like 1						nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
CIC	23152	broad.mit.edu	37	19	42792902	42792902	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42792902delT	uc002otf.1	+							NM_015125	NP_055940			capicua homolog						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)						T	DUX4	soft tissue sarcoma								---	---	---	---
SFRS16	11129	broad.mit.edu	37	19	45573563	45573564	+	Intron	DEL	AC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45573563_45573564delAC	uc002pak.2	+						SFRS16_uc002pal.2_Intron|SFRS16_uc010xxh.1_Intron|SFRS16_uc002pam.2_Intron	NM_007056	NP_008987			splicing factor, arginine/serine-rich 16						mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	46722778	46722778	+	IGR	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46722778delC								DKFZp434J0226 (4686 upstream) : IGFL1 (10231 downstream)																																			---	---	---	---
GLTSCR2	29997	broad.mit.edu	37	19	48254709	48254709	+	Intron	DEL	G	-	-	rs112625343	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48254709delG	uc002phm.2	+						GLTSCR2_uc002phk.2_Intron|GLTSCR2_uc002phl.2_Intron|GLTSCR2_uc010elj.2_Intron|GLTSCR2_uc010elk.1_5'Flank	NM_015710	NP_056525			glioma tumor suppressor candidate region gene 2							nucleolus				central_nervous_system(1)	1		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)														---	---	---	---
PRR12	57479	broad.mit.edu	37	19	50123757	50123757	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50123757delG	uc002poo.3	+							NM_020719	NP_065770			proline rich 12								DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	52896073	52896074	+	IGR	DEL	TA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52896073_52896074delTA								ZNF880 (7029 upstream) : ZNF528 (5047 downstream)																																			---	---	---	---
PTPRH	5794	broad.mit.edu	37	19	55703327	55703329	+	Intron	DEL	CCT	-	-	rs10545294		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55703327_55703329delCCT	uc002qjq.2	-						PTPRH_uc010esv.2_Intron|uc002qjr.2_In_Frame_Del_p.L142del	NM_002842	NP_002833			protein tyrosine phosphatase, receptor type, H						apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)														---	---	---	---
AURKC	6795	broad.mit.edu	37	19	57745123	57745123	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57745123delT	uc002qoe.2	+						AURKC_uc002qoc.2_Intron|AURKC_uc002qod.2_Intron|AURKC_uc010etv.2_Intron	NM_001015878	NP_001015878			aurora kinase C isoform 1						cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)														---	---	---	---
XRN2	22803	broad.mit.edu	37	20	21362539	21362539	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21362539delT	uc002wsf.1	+						XRN2_uc002wsg.1_Intron|XRN2_uc010zsk.1_Intron|XRN2_uc002wsh.1_5'UTR	NM_012255	NP_036387			5'-3' exoribonuclease 2						cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	20	25900372	25900372	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25900372delA								FAM182B (51586 upstream) : LOC100134868 (90063 downstream)																																			---	---	---	---
ITCH	83737	broad.mit.edu	37	20	33069165	33069165	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33069165delT	uc010geu.1	+						ITCH_uc002xak.2_Intron|ITCH_uc010zuj.1_Intron	NM_031483	NP_113671			itchy homolog E3 ubiquitin protein ligase						apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6																		---	---	---	---
DHX35	60625	broad.mit.edu	37	20	37623275	37623277	+	Intron	DEL	CCC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37623275_37623277delCCC	uc002xjh.2	+						DHX35_uc010zwa.1_Intron|DHX35_uc010zwb.1_Intron|DHX35_uc010zwc.1_Intron	NM_021931	NP_068750			DEAH (Asp-Glu-Ala-His) box polypeptide 35							catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
SEMG2	6407	broad.mit.edu	37	20	43837376	43837376	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43837376delT	uc010ggz.2	+						SEMG1_uc002xni.2_Intron|SEMG1_uc002xnj.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003008	NP_002999			semenogelin II precursor						sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
Unknown	0	broad.mit.edu	37	20	44119407	44119407	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44119407delA								WFDC2 (9236 upstream) : SPINT3 (21694 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	20	53383380	53383380	+	IGR	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:53383380delC								DOK5 (115671 upstream) : None (None downstream)																																			---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58494493	58494493	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58494493delT	uc002yaz.2	-						SYCP2_uc010gju.1_Intron	NM_014258	NP_055073			synaptonemal complex protein 2						cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
Unknown	0	broad.mit.edu	37	20	58889651	58889662	+	Intron	DEL	CATTCTCCCATT	-	-	rs114216255	by1000genomes;by1000genomes;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58889651_58889662delCATTCTCCCATT	uc002ybl.2	+						uc010gjw.1_Intron					Homo sapiens cDNA FLJ35486 fis, clone SMINT2008491.																														---	---	---	---
USP25	29761	broad.mit.edu	37	21	17203605	17203605	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:17203605delA	uc002yjy.1	+						USP25_uc011aby.1_Intron|USP25_uc002yjz.1_Intron|USP25_uc010gla.1_Intron	NM_013396	NP_037528			ubiquitin specific peptidase 25						protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)														---	---	---	---
C21orf91	54149	broad.mit.edu	37	21	19190307	19190307	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:19190307delA	uc002yko.3	-						C21orf91_uc002ykq.3_Intron|C21orf91_uc002ykp.3_Intron	NM_001100420	NP_001093890			early undifferentiated retina and lens isoform											ovary(1)	1				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)														---	---	---	---
Unknown	0	broad.mit.edu	37	21	21112410	21112412	+	IGR	DEL	AGA	-	-	rs1829338	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:21112410_21112412delAGA								None (None upstream) : None (None downstream)																																			---	---	---	---
APP	351	broad.mit.edu	37	21	27327077	27327077	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:27327077delT	uc002ylz.2	-						APP_uc011acg.1_Intron|APP_uc010glk.2_Intron|APP_uc002yma.2_Intron|APP_uc011ach.1_Intron|APP_uc002ymb.2_Intron|APP_uc010glj.2_Intron|APP_uc011aci.1_Intron	NM_000484	NP_000475			amyloid beta A4 protein isoform a precursor						adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)																---	---	---	---
RNF160	26046	broad.mit.edu	37	21	30332708	30332708	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30332708delA	uc002ymr.2	-							NM_015565	NP_056380			zinc finger protein 294								ligase activity|zinc ion binding				0																		---	---	---	---
GART	2618	broad.mit.edu	37	21	34903299	34903299	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34903299delT	uc002yrx.2	-						GART_uc002yrz.2_Intron|GART_uc010gmd.2_Intron|GART_uc002yry.2_Intron|GART_uc002ysa.2_Intron	NM_000819	NP_000810			phosphoribosylglycinamide formyltransferase,						'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)													---	---	---	---
CBS	875	broad.mit.edu	37	21	44476001	44476001	+	Intron	DEL	T	-	-	rs79861734		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44476001delT	uc002zcu.2	-						CBS_uc002zcs.1_Intron|CBS_uc002zct.2_Intron|CBS_uc002zcw.3_Intron|CBS_uc002zcv.2_Intron|CBS_uc002zcx.2_3'UTR	NM_000071	NP_000062			cystathionine-beta-synthase						cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)													---	---	---	---
AIRE	326	broad.mit.edu	37	21	45710105	45710105	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45710105delT	uc002zei.2	+						AIRE_uc010gpq.2_5'Flank|AIRE_uc002zej.2_5'Flank|AIRE_uc010gpr.2_5'Flank	NM_000383	NP_000374			autoimmune regulator isoform 1						positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)										Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				---	---	---	---
Unknown	0	broad.mit.edu	37	22	16419352	16419352	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:16419352delT								POTEH (131415 upstream) : OR11H1 (29474 downstream)																																			---	---	---	---
LOC96610	96610	broad.mit.edu	37	22	22540970	22540970	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22540970delA	uc011aim.1	+											Parts of antibodies, mostly variable regions.												0																		---	---	---	---
MYO18B	84700	broad.mit.edu	37	22	26402277	26402277	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26402277delT	uc003abz.1	+						MYO18B_uc003aca.1_Intron|MYO18B_uc010guy.1_Intron|MYO18B_uc010guz.1_Intron|MYO18B_uc011aka.1_Intron|MYO18B_uc011akb.1_Intron|MYO18B_uc010gva.1_Intron	NM_032608	NP_115997			myosin XVIIIB							nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12																		---	---	---	---
EWSR1	2130	broad.mit.edu	37	22	29683188	29683188	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29683188delT	uc003aet.2	+						EWSR1_uc003aes.3_Intron|EWSR1_uc003aev.2_Intron|EWSR1_uc003aew.2_Intron|EWSR1_uc003aex.2_Intron|EWSR1_uc003aey.2_Intron|EWSR1_uc003aez.2_5'Flank	NM_005243	NP_005234			Ewing sarcoma breakpoint region 1 isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254								T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								---	---	---	---
HORMAD2	150280	broad.mit.edu	37	22	30507905	30507906	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30507905_30507906delTT	uc003agy.2	+							NM_152510	NP_689723			HORMA domain containing 2						meiosis|mitosis	chromosome|nucleus					0			Epithelial(10;0.125)															---	---	---	---
TBC1D10A	83874	broad.mit.edu	37	22	30691593	30691593	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30691593delA	uc011akt.1	-						GATSL3_uc003ahf.2_Intron|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Intron|TBC1D10A_uc003ahj.3_Intron|TBC1D10A_uc010gvu.2_Intron|TBC1D10A_uc003ahk.3_Intron	NM_031937	NP_114143			TBC1 domain family, member 10A							intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
MORC2	22880	broad.mit.edu	37	22	31329912	31329912	+	Intron	DEL	G	-	-	rs71740454		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31329912delG	uc003aje.1	-							NM_014941	NP_055756			MORC family CW-type zinc finger 2								ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2																		---	---	---	---
DEPDC5	9681	broad.mit.edu	37	22	32188592	32188605	+	Intron	DEL	AAAAAAAAAAAAAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32188592_32188605delAAAAAAAAAAAAAA	uc003als.2	+						DEPDC5_uc011als.1_Intron|DEPDC5_uc011alu.1_Intron|DEPDC5_uc011alv.1_Intron|DEPDC5_uc003alt.2_Intron|DEPDC5_uc003alr.1_Intron|DEPDC5_uc011alt.1_Intron	NM_014662	NP_055477			DEP domain containing 5 isoform 1						intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8																		---	---	---	---
SLC5A1	6523	broad.mit.edu	37	22	32481283	32481283	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32481283delT	uc003amc.2	+						SLC5A1_uc011alz.1_Intron	NM_000343	NP_000334			solute carrier family 5 (sodium/glucose						carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1																		---	---	---	---
MFNG	4242	broad.mit.edu	37	22	37876043	37876043	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37876043delA	uc003ass.1	-						MFNG_uc011ani.1_Intron|MFNG_uc011anj.1_Intron|CARD10_uc003ast.1_Intron	NM_002405	NP_002396			O-fucosylpeptide						pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)																	---	---	---	---
XPNPEP3	63929	broad.mit.edu	37	22	41264850	41264850	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41264850delA	uc003azh.2	+						XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_Intron|XPNPEP3_uc010gyh.1_Intron	NM_022098	NP_071381			X-prolyl aminopeptidase (aminopeptidase P) 3,						cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity				0																		---	---	---	---
SAMM50	25813	broad.mit.edu	37	22	44353271	44353271	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44353271delA	uc003bej.2	+						PNPLA3_uc010gzm.1_Intron|SAMM50_uc011aqd.1_Intron	NM_015380	NP_056195			sorting and assembly machinery component 50						protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			skin(1)	1		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)																---	---	---	---
LMF2	91289	broad.mit.edu	37	22	50942703	50942704	+	Intron	INS	-	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50942703_50942704insC	uc003blp.2	-						LMF2_uc010hba.2_Intron|LMF2_uc003blo.2_Intron	NM_033200	NP_149977			lipase maturation factor 2							endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
Unknown	0	broad.mit.edu	37	X	12845011	12845011	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:12845011delA								PRPS2 (2669 upstream) : TLR7 (40191 downstream)																																			---	---	---	---
OFD1	8481	broad.mit.edu	37	X	13764946	13764946	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:13764946delA	uc004cvp.3	+	8	1061	c.702delA	c.(700-702)GCAfs	p.A234fs	OFD1_uc004cvr.3_5'UTR|OFD1_uc011mil.1_5'UTR|OFD1_uc004cvq.3_Frame_Shift_Del_p.A94fs|OFD1_uc010nen.2_Frame_Shift_Del_p.A233fs|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Frame_Shift_Del_p.A233fs|OFD1_uc004cvv.3_Frame_Shift_Del_p.A233fs|OFD1_uc010neo.1_Frame_Shift_Del_p.A20fs	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	234	Potential.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0																		---	---	---	---
CTPS2	56474	broad.mit.edu	37	X	16721146	16721150	+	Intron	DEL	TTTTT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16721146_16721150delTTTTT	uc004cxk.2	-						CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_001144002	NP_001137474			cytidine triphosphate synthase II						glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
SCML2	10389	broad.mit.edu	37	X	18343207	18343209	+	Intron	DEL	AAA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18343207_18343209delAAA	uc004cyl.2	-						SCML2_uc004cyk.3_Intron|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron	NM_006089	NP_006080			sex comb on midleg-like 2						anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
CDKL5	6792	broad.mit.edu	37	X	18631426	18631426	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18631426delT	uc004cym.2	+						CDKL5_uc004cyn.2_Intron	NM_003159	NP_003150			cyclin-dependent kinase-like 5						neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)																	---	---	---	---
PPEF1	5475	broad.mit.edu	37	X	18748213	18748213	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18748213delT	uc004cyq.2	+						PPEF1_uc004cyp.2_Intron|PPEF1_uc004cyr.2_Intron|PPEF1_uc004cys.2_Intron|PPEF1_uc011mja.1_Intron|PPEF1_uc011mjb.1_5'Flank	NM_006240	NP_006231			protein phosphatase with EF hand calcium-binding						detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)																	---	---	---	---
PRDX4	10549	broad.mit.edu	37	X	23702004	23702005	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23702004_23702005delAA	uc004dam.2	+							NM_006406	NP_006397			peroxiredoxin 4						cell redox homeostasis|I-kappaB phosphorylation		thioredoxin peroxidase activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
APOO	79135	broad.mit.edu	37	X	23896839	23896847	+	Intron	DEL	CTTGCTATT	-	-	rs56274557		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23896839_23896847delCTTGCTATT	uc004dax.2	-						APOO_uc004daw.2_Intron|APOO_uc004day.3_Intron	NM_024122	NP_077027			apolipoprotein O precursor						lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0																		---	---	---	---
CXorf59	286464	broad.mit.edu	37	X	36117798	36117799	+	Intron	INS	-	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:36117798_36117799insA	uc004ddk.1	+							NM_173695	NP_775966			hypothetical protein LOC286464							integral to membrane				central_nervous_system(1)	1																		---	---	---	---
USP9X	8239	broad.mit.edu	37	X	41069679	41069679	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41069679delT	uc004dfb.2	+						USP9X_uc004dfc.2_Intron	NM_001039590	NP_001034679			ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6																		---	---	---	---
DDX3X	1654	broad.mit.edu	37	X	41206551	41206551	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41206551delT	uc004dfe.2	+						DDX3X_uc004dff.2_Intron|DDX3X_uc011mkq.1_Intron|DDX3X_uc011mkr.1_Intron|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_Intron	NM_001356	NP_001347			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3						interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6															HNSCC(61;0.18)			---	---	---	---
ZNF157	7712	broad.mit.edu	37	X	47230158	47230158	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47230158delT	uc004dhr.1	+							NM_003446	NP_003437			zinc finger protein 157						negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
SSX5	6758	broad.mit.edu	37	X	48046901	48046901	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48046901delA	uc004dja.1	-						SSX5_uc004diz.1_Intron	NM_175723	NP_783729			synovial sarcoma, X breakpoint 5 isoform b						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0																		---	---	---	---
PAGE1	8712	broad.mit.edu	37	X	49458625	49458630	+	Intron	DEL	ACACAC	-	-	rs72312865		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49458625_49458630delACACAC	uc004dom.2	-							NM_003785	NP_003776			P antigen family, member 1						cellular defense response					skin(1)	1	Ovarian(276;0.236)																	---	---	---	---
KLF8	11279	broad.mit.edu	37	X	56310720	56310720	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:56310720delT	uc004dur.2	+						KLF8_uc011mop.1_Intron|KLF8_uc010nkh.2_Intron	NM_007250	NP_009181			Kruppel-like factor 8 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
MTMR8	55613	broad.mit.edu	37	X	63557062	63557062	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:63557062delA	uc004dvs.2	-						MTMR8_uc011mou.1_Intron|MTMR8_uc004dvt.1_Intron	NM_017677	NP_060147			myotubularin related protein 8							nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4																		---	---	---	---
ZC4H2	55906	broad.mit.edu	37	X	64139033	64139033	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64139033delG	uc004dvu.2	-	4	538	c.450delC	c.(448-450)CCCfs	p.P150fs	ZC4H2_uc004dvv.2_Frame_Shift_Del_p.P127fs|ZC4H2_uc011mov.1_Frame_Shift_Del_p.P127fs|ZC4H2_uc011mow.1_Intron|ZC4H2_uc004dvw.1_3'UTR	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	150							metal ion binding|protein binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	64548402	64548402	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64548402delT								ZC4H2 (293809 upstream) : ZC3H12B (160304 downstream)																																			---	---	---	---
MSN	4478	broad.mit.edu	37	X	64952923	64952923	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64952923delA	uc004dwf.2	+							NM_002444	NP_002435			moesin						leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10								T	ALK	ALCL								---	---	---	---
TEX11	56159	broad.mit.edu	37	X	70127618	70127618	+	5'UTR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70127618delA	uc004dyl.2	-	2					TEX11_uc004dym.2_Frame_Shift_Del_p.S8fs	NM_001003811	NP_001003811			testis expressed sequence 11 isoform 1								protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)																	---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70627378	70627378	+	Intron	DEL	T	-	-	rs78058922		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70627378delT	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_Intron|TAF1_uc010nle.1_Intron|TAF1_uc010nlf.1_Intron|TAF1_uc004dzx.2_Intron|TAF1_uc004dzy.2_Intron	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70639873	70639873	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70639873delT	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_Intron|TAF1_uc010nle.1_Intron|TAF1_uc010nlf.1_Intron|TAF1_uc004dzx.2_Intron|TAF1_uc004dzy.2_Intron	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70643256	70643256	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70643256delT	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_Intron|TAF1_uc010nle.1_Intron|TAF1_uc010nlf.1_Intron|TAF1_uc004dzx.2_Intron|TAF1_uc004dzy.2_Intron|TAF1_uc004dzw.1_Intron	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
OGT	8473	broad.mit.edu	37	X	70767677	70767677	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70767677delT	uc004eaa.1	+						BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Intron|OGT_uc004eac.2_Frame_Shift_Del_p.L12fs|OGT_uc004ead.2_5'UTR	NM_181672	NP_858058			O-linked GlcNAc transferase isoform 1						cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)																	---	---	---	---
ZDHHC15	158866	broad.mit.edu	37	X	74651360	74651361	+	Intron	DEL	AA	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:74651360_74651361delAA	uc004ecg.2	-						ZDHHC15_uc004ech.2_Intron|ZDHHC15_uc011mqo.1_Intron	NM_144969	NP_659406			zinc finger, DHHC-type containing 15 isoform 1							integral to membrane	zinc ion binding			ovary(2)	2																		---	---	---	---
PCDH19	57526	broad.mit.edu	37	X	99662505	99662505	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:99662505delG	uc010nmz.2	-	1	2767	c.1091delC	c.(1090-1092)CCGfs	p.P364fs	PCDH19_uc004efw.3_Frame_Shift_Del_p.P364fs|PCDH19_uc004efx.3_Frame_Shift_Del_p.P364fs	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	364	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7																		---	---	---	---
CENPI	2491	broad.mit.edu	37	X	100357486	100357487	+	Intron	DEL	AC	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100357486_100357487delAC	uc004egx.2	+						CENPI_uc011mrg.1_Intron|CENPI_uc004egy.2_Intron	NM_006733	NP_006724			centromere protein I						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1																		---	---	---	---
GPRASP2	114928	broad.mit.edu	37	X	101972170	101972170	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:101972170delA	uc004ejk.2	+	4	3707	c.2373delA	c.(2371-2373)ATAfs	p.I791fs	GPRASP2_uc004ejl.2_Frame_Shift_Del_p.I791fs|GPRASP2_uc004ejm.2_Frame_Shift_Del_p.I791fs|GPRASP2_uc011mrp.1_Frame_Shift_Del_p.I130fs	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	791						cytoplasm	protein binding			ovary(1)	1																		---	---	---	---
COL4A6	1288	broad.mit.edu	37	X	107464328	107464328	+	Intron	DEL	A	-	-	rs76891094		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107464328delA	uc004enw.3	-						COL4A6_uc004env.3_Intron|COL4A6_uc011msn.1_Intron|COL4A6_uc010npk.2_Intron	NM_001847	NP_001838			type IV alpha 6 collagen isoform A precursor						cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8														Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---	---
AGTR2	186	broad.mit.edu	37	X	115303402	115303402	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:115303402delT	uc004eqh.3	+							NM_000686	NP_000677			angiotensin II receptor, type 2						behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3																		---	---	---	---
DOCK11	139818	broad.mit.edu	37	X	117722082	117722082	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117722082delT	uc004eqp.2	+						DOCK11_uc004eqq.2_Intron	NM_144658	NP_653259			dedicator of cytokinesis 11						blood coagulation	cytosol	GTP binding			ovary(3)	3																		---	---	---	---
CUL4B	8450	broad.mit.edu	37	X	119671835	119671835	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119671835delT	uc004esw.2	-						CUL4B_uc010nqq.2_Intron|CUL4B_uc004esv.2_Intron	NM_003588	NP_003579			cullin 4B isoform 1						cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
STAG2	10735	broad.mit.edu	37	X	123191900	123191900	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123191900delA	uc004etz.3	+						STAG2_uc004eua.2_Intron|STAG2_uc004eub.2_Intron|STAG2_uc004euc.2_Intron|STAG2_uc004eud.2_Intron|STAG2_uc004eue.2_Intron	NM_006603	NP_006594			stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5																		---	---	---	---
UTP14A	10813	broad.mit.edu	37	X	129058758	129058758	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129058758delT	uc004euz.2	+						UTP14A_uc011mup.1_Intron|UTP14A_uc011muq.1_Intron	NM_006649	NP_006640			UTP14, U3 small nucleolar ribonucleoprotein,						rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2																		---	---	---	---
PHF6	84295	broad.mit.edu	37	X	133528164	133528165	+	Intron	DEL	TT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133528164_133528165delTT	uc004exj.2	+						PHF6_uc004exk.2_Intron|PHF6_uc011mvk.1_Intron|PHF6_uc004exh.2_Intron|PHF6_uc010nrr.2_Intron|PHF6_uc004exi.2_Intron	NM_001015877	NP_001015877			PHD finger protein 6 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
FAM122C	159091	broad.mit.edu	37	X	133963107	133963107	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133963107delT	uc004exz.1	+						FAM122C_uc011mvq.1_Intron|FAM122C_uc004exy.1_Intron	NM_138819	NP_620174			hypothetical protein LOC159091												0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	134808304	134808304	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134808304delT								DDX26B (91845 upstream) : CT45A1 (38881 downstream)																																			---	---	---	---
VGLL1	51442	broad.mit.edu	37	X	135630679	135630679	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135630679delA	uc004ezy.2	+						MIR934_hsa-mir-934|MI0005756_5'Flank	NM_016267	NP_057351			vestigial like 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	137565675	137565675	+	IGR	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:137565675delA								ZIC3 (911418 upstream) : LOC158696 (131217 downstream)																																			---	---	---	---
MCF2	4168	broad.mit.edu	37	X	138698757	138698757	+	Intron	DEL	A	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138698757delA	uc004fau.2	-						MCF2_uc004fav.2_Intron|MCF2_uc011mwl.1_Intron|MCF2_uc010nsh.1_Intron|MCF2_uc011mwm.1_Intron|MCF2_uc011mwn.1_Intron|MCF2_uc004faw.2_Intron|MCF2_uc011mwo.1_Intron	NM_005369	NP_005360			MCF.2 cell line derived transforming sequence						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ATP11C	286410	broad.mit.edu	37	X	138914292	138914295	+	Intron	DEL	AAAT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138914292_138914295delAAAT	uc004faz.2	-						ATP11C_uc004fba.2_Intron	NM_173694	NP_775965			ATPase, class VI, type 11C isoform a						ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
PASD1	139135	broad.mit.edu	37	X	150816900	150816900	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150816900delT	uc004fev.3	+							NM_173493	NP_775764			PAS domain containing 1							nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PNCK	139728	broad.mit.edu	37	X	152937973	152937973	+	Intron	DEL	C	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152937973delC	uc011myu.1	-						PNCK_uc011myt.1_Intron|PNCK_uc004fia.2_Intron|PNCK_uc004fhz.3_Intron|PNCK_uc010nuh.2_Intron|PNCK_uc011myv.1_Intron|PNCK_uc011myw.1_Intron	NM_001039582	NP_001034671			pregnancy upregulated non-ubiquitously expressed							cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
IRAK1	3654	broad.mit.edu	37	X	153284406	153284406	+	Intron	DEL	G	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153284406delG	uc004fjs.1	-						IRAK1_uc004fjr.1_Intron|IRAK1_uc004fjt.1_Intron|IRAK1_uc010nur.2_Intron|IRAK1_uc004fju.2_Intron	NM_001569	NP_001560			interleukin-1 receptor-associated kinase 1						activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	153680002	153680002	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153680002delT								FAM50A (1001 upstream) : PLXNA3 (6621 downstream)																																			---	---	---	---
DKC1	1736	broad.mit.edu	37	X	153994123	153994123	+	Intron	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153994123delT	uc004fmm.2	+						DKC1_uc010nvf.2_Intron|SNORA36A_uc004fmn.2_5'Flank	NM_001363	NP_001354			dyskerin isoform 1						cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)													Congenital_Dyskeratosis				---	---	---	---
F8	2157	broad.mit.edu	37	X	154148489	154148491	+	Intron	DEL	TTT	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154148489_154148491delTTT	uc004fmt.2	-							NM_000132	NP_000123			coagulation factor VIII isoform a precursor						acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)													---	---	---	---
Unknown	0	broad.mit.edu	37	Y	13524407	13524407	+	IGR	DEL	T	-	-			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:13524407delT								None (None upstream) : None (None downstream)																																			---	---	---	---
FAM132A	388581	broad.mit.edu	37	1	1179802	1179802	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1179802C>G	uc001adl.1	-	2	285	c.253G>C	c.(253-255)GGC>CGC	p.G85R		NM_001014980	NP_001014980	Q5T7M4	F132A_HUMAN	family with sequence similarity 132, member A	85						extracellular region					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
UBE2J2	118424	broad.mit.edu	37	1	1190787	1190787	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1190787G>A	uc001adn.2	-	7	886	c.576C>T	c.(574-576)GAC>GAT	p.D192D	UBE2J2_uc001adm.2_Silent_p.D157D|UBE2J2_uc001ado.2_Silent_p.D208D|UBE2J2_uc001adp.2_Silent_p.D192D|UBE2J2_uc001adq.2_Silent_p.D140D|UBE2J2_uc001adr.2_Silent_p.D140D|UBE2J2_uc001ads.2_Silent_p.D140D	NM_194458	NP_919440	Q8N2K1	UB2J2_HUMAN	ubiquitin conjugating enzyme E2, J2 isoform 3	192	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)														---	---	---	---
PUSL1	126789	broad.mit.edu	37	1	1246700	1246700	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1246700C>T	uc001aed.2	+						ACAP3_uc001aec.1_5'Flank|PUSL1_uc010nyi.1_Intron|PUSL1_uc009vjx.2_Intron	NM_153339	NP_699170			pseudouridylate synthase-like 1						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	1854872	1854872	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1854872C>T	uc001aik.2	-	8	1304	c.454G>A	c.(454-456)GAC>AAC	p.D152N	uc001ail.2_Missense_Mutation_p.D152N					RecName: Full=Uncharacterized protein C1orf222;																														---	---	---	---
KIAA0562	9731	broad.mit.edu	37	1	3732035	3732035	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3732035G>A	uc001aky.2	-	22	3068	c.2709C>T	c.(2707-2709)GCC>GCT	p.A903A	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	903						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)														---	---	---	---
KIAA0562	9731	broad.mit.edu	37	1	3742925	3742925	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3742925G>A	uc001aky.2	-						KIAA0562_uc010nzm.1_Intron	NM_014704	NP_055519			glycine-, glutamate-,							centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)														---	---	---	---
PLEKHG5	57449	broad.mit.edu	37	1	6537676	6537676	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6537676G>C	uc001ano.1	-	3	225	c.124C>G	c.(124-126)CCC>GCC	p.P42A	PLEKHG5_uc001ann.1_Missense_Mutation_p.P23A|PLEKHG5_uc001anq.1_Missense_Mutation_p.P63A|PLEKHG5_uc001anp.1_Missense_Mutation_p.P63A|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Missense_Mutation_p.P55A|PLEKHG5_uc001ank.1_5'UTR|PLEKHG5_uc009vmb.1_5'UTR|PLEKHG5_uc001anl.1_5'UTR|PLEKHG5_uc001anm.1_5'UTR	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	42					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
ENO1	2023	broad.mit.edu	37	1	8922984	8922984	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8922984G>A	uc001apj.1	-	11	1348	c.1197C>T	c.(1195-1197)TGC>TGT	p.C399C	ENO1_uc001api.1_Silent_p.C303C|ENO1_uc001apk.1_Silent_p.C344C|ENO1_uc001apl.1_Intron|ENO1_uc009vmi.1_Silent_p.C356C|ENO1_uc009vmj.1_Intron|ENO1_uc009vmk.1_Silent_p.C273C	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	399					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)												OREG0013068	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MIIP	60672	broad.mit.edu	37	1	12082939	12082939	+	Missense_Mutation	SNP	G	A	A	rs150662495		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12082939G>A	uc001ato.1	+	4	692	c.512G>A	c.(511-513)CGC>CAC	p.R171H		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	171										ovary(1)	1																		---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16256697	16256697	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16256697C>T	uc001axk.1	+	11	4166	c.3962C>T	c.(3961-3963)GCA>GTA	p.A1321V	SPEN_uc010obp.1_Missense_Mutation_p.A1280V	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1321					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16259137	16259137	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16259137A>G	uc001axk.1	+	11	6606	c.6402A>G	c.(6400-6402)TCA>TCG	p.S2134S	SPEN_uc010obp.1_Silent_p.S2093S	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2134	Interaction with MSX2 (By similarity).				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
CROCC	9696	broad.mit.edu	37	1	17250929	17250929	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17250929C>T	uc001azt.2	+	3	375	c.306C>T	c.(304-306)GCC>GCT	p.A102A	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_Intron	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	102	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)														---	---	---	---
ARHGEF10L	55160	broad.mit.edu	37	1	17958909	17958909	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17958909C>A	uc001ban.2	+	16	1837	c.1678C>A	c.(1678-1680)CGT>AGT	p.R560S	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.R521S|ARHGEF10L_uc001bao.2_Missense_Mutation_p.R521S|ARHGEF10L_uc001bap.2_Missense_Mutation_p.R521S|ARHGEF10L_uc010ocr.1_Missense_Mutation_p.R318S|ARHGEF10L_uc001baq.2_Missense_Mutation_p.R326S|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.R338S|ARHGEF10L_uc001bar.2_Missense_Mutation_p.R268S|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	560					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)														---	---	---	---
KLHDC7A	127707	broad.mit.edu	37	1	18807675	18807675	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:18807675C>T	uc001bax.2	+	1	252	c.200C>T	c.(199-201)GCT>GTT	p.A67V	KLHDC7A_uc009vpg.2_5'UTR	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	67						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
KLHDC7A	127707	broad.mit.edu	37	1	18809031	18809031	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:18809031G>A	uc001bax.2	+	1	1608	c.1556G>A	c.(1555-1557)CGC>CAC	p.R519H	KLHDC7A_uc009vpg.2_Missense_Mutation_p.R301H	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	519	Kelch 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
HTR6	3362	broad.mit.edu	37	1	19992413	19992413	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19992413C>T	uc001bcl.2	+	1	634	c.167C>T	c.(166-168)GCG>GTG	p.A56V		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	56	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)													---	---	---	---
MUL1	79594	broad.mit.edu	37	1	20827514	20827514	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:20827514A>G	uc001bdi.3	-	4	885	c.728T>C	c.(727-729)CTG>CCG	p.L243P		NM_024544	NP_078820	Q969V5	MUL1_HUMAN	mitochondrial ubiquitin ligase activator of NFKB	243	Helical; (Potential).				activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)														---	---	---	---
SH2D5	400745	broad.mit.edu	37	1	21052443	21052443	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21052443G>A	uc001bdt.1	-	4	733	c.108C>T	c.(106-108)TGC>TGT	p.C36C	SH2D5_uc009vpy.1_Silent_p.C120C|SH2D5_uc001bdu.1_Intron	NM_001103160	NP_001096630	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5 isoform 2	36											0		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
EPHB2	2048	broad.mit.edu	37	1	23208888	23208888	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23208888G>A	uc009vqj.1	+	6	1485	c.1340G>A	c.(1339-1341)CGC>CAC	p.R447H	EPHB2_uc001bge.2_Missense_Mutation_p.R447H|EPHB2_uc001bgf.2_Missense_Mutation_p.R447H|EPHB2_uc010odu.1_Missense_Mutation_p.R447H	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	447	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)										Hereditary_Prostate_Cancer				---	---	---	---
TCEB3	6924	broad.mit.edu	37	1	24083458	24083458	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24083458G>A	uc001bho.2	+	10	2238	c.2178G>A	c.(2176-2178)CCG>CCA	p.P726P		NM_003198	NP_003189	Q14241	ELOA1_HUMAN	elongin A	726					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)														---	---	---	---
SRRM1	10250	broad.mit.edu	37	1	24989225	24989225	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24989225C>T	uc001bjm.2	+	12	1782	c.1558C>T	c.(1558-1560)CGG>TGG	p.R520W	SRRM1_uc010oel.1_Missense_Mutation_p.R518W|SRRM1_uc009vrh.1_Missense_Mutation_p.R479W|SRRM1_uc009vri.1_Missense_Mutation_p.R435W|SRRM1_uc010oem.1_RNA	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	520	Necessary for speckles and matrix localization.|Arg-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)														---	---	---	---
LIN28A	79727	broad.mit.edu	37	1	26751934	26751934	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26751934G>A	uc001bmj.2	+	3	483	c.369G>A	c.(367-369)CGG>CGA	p.R123R	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	123					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
WASF2	10163	broad.mit.edu	37	1	27744891	27744891	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27744891A>T	uc001bof.1	-	4	514	c.298T>A	c.(298-300)TTC>ATC	p.F100I	WASF2_uc010ofl.1_Missense_Mutation_p.F100I	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	100					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)														---	---	---	---
AHDC1	27245	broad.mit.edu	37	1	27875066	27875066	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27875066G>A	uc009vsy.2	-	6	4530	c.3561C>T	c.(3559-3561)AGC>AGT	p.S1187S	AHDC1_uc009vsz.1_Silent_p.S1187S	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1187							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)														---	---	---	---
RPA2	6118	broad.mit.edu	37	1	28218705	28218705	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28218705T>G	uc001bpe.1	-	9	1064	c.782A>C	c.(781-783)GAT>GCT	p.D261A	RPA2_uc001bpd.1_Missense_Mutation_p.D269A|RPA2_uc010ofp.1_Missense_Mutation_p.D165A	NM_002946	NP_002937	P15927	RFA2_HUMAN	replication protein A2, 32kDa	261	Asp/Glu-rich (acidic).|Interaction with TIPIN (By similarity).				cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|regulation of double-strand break repair via homologous recombination|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor A complex|PML body	protein phosphatase binding|single-stranded DNA binding			skin(1)	1		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.62e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00294)|STAD - Stomach adenocarcinoma(196;0.00308)|BRCA - Breast invasive adenocarcinoma(304;0.00613)|READ - Rectum adenocarcinoma(331;0.0649)									Direct_reversal_of_damage|NER					---	---	---	---
PTPRU	10076	broad.mit.edu	37	1	29638251	29638251	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29638251C>T	uc001bru.2	+	22	3192	c.3082C>T	c.(3082-3084)CGC>TGC	p.R1028C	PTPRU_uc001brv.2_Missense_Mutation_p.R1024C|PTPRU_uc001brw.2_Missense_Mutation_p.R1018C|PTPRU_uc009vtq.2_Missense_Mutation_p.R1024C|PTPRU_uc009vtr.2_Missense_Mutation_p.R1015C	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1028	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)														---	---	---	---
NCDN	23154	broad.mit.edu	37	1	36028856	36028856	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36028856T>A	uc001bza.2	+	6	1566	c.1439T>A	c.(1438-1440)ATC>AAC	p.I480N	NCDN_uc001bzb.2_Missense_Mutation_p.I480N|NCDN_uc001bzc.2_Missense_Mutation_p.I463N	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1	480					neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
CSF3R	1441	broad.mit.edu	37	1	36932116	36932116	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36932116T>C	uc001caw.1	-	17	2531	c.2353A>G	c.(2353-2355)AAG>GAG	p.K785E	MRPS15_uc001cas.2_5'Flank|CSF3R_uc001cat.1_Missense_Mutation_p.K347E|CSF3R_uc009vvc.1_Missense_Mutation_p.K314E|CSF3R_uc001cau.1_Missense_Mutation_p.K185E|CSF3R_uc001cav.1_Intron|CSF3R_uc001cax.1_Missense_Mutation_p.K812E|CSF3R_uc001cay.1_Silent_p.P753P	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	785	Cytoplasmic (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)													---	---	---	---
MTF1	4520	broad.mit.edu	37	1	38304324	38304324	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38304324C>T	uc001cce.1	-	4	893	c.752G>A	c.(751-753)CGA>CAA	p.R251Q	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	251	C2H2-type 4.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)																---	---	---	---
GJA9	81025	broad.mit.edu	37	1	39340211	39340211	+	3'UTR	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39340211G>A	uc001cct.1	-	2					RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399			gap junction protein, alpha 9, 59kDa						cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)															---	---	---	---
RLF	6018	broad.mit.edu	37	1	40702626	40702626	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40702626C>T	uc001cfc.3	+	8	2283	c.2252C>T	c.(2251-2253)GCT>GTT	p.A751V	RLF_uc001cfd.3_Missense_Mutation_p.A442V	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	751	C2H2-type 4.				chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)															---	---	---	---
SMAP2	64744	broad.mit.edu	37	1	40880951	40880951	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40880951T>C	uc001cfj.2	+	7	644	c.579T>C	c.(577-579)CCT>CCC	p.P193P	SMAP2_uc010ojh.1_Silent_p.P193P|SMAP2_uc001cfk.2_Silent_p.P163P|SMAP2_uc010oji.1_Silent_p.P110P|SMAP2_uc010ojj.1_Silent_p.P9P	NM_022733	NP_073570	Q8WU79	SMAP2_HUMAN	small ArfGAP2	193	Interaction with clathrin heavy chains (By similarity).				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding				0	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)															---	---	---	---
ZNF642	339559	broad.mit.edu	37	1	40961306	40961306	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40961306A>G	uc001cfo.2	+	6	1450	c.1156A>G	c.(1156-1158)AAT>GAT	p.N386D	ZNF642_uc009vwb.2_Missense_Mutation_p.N386D|ZNF642_uc010ojk.1_Missense_Mutation_p.N387D	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	386	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)															---	---	---	---
RIMKLA	284716	broad.mit.edu	37	1	42880544	42880544	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:42880544C>T	uc001chi.2	+	5	1213	c.1075C>T	c.(1075-1077)CGG>TGG	p.R359W		NM_173642	NP_775913	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family	359					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0																		---	---	---	---
ZMYND12	84217	broad.mit.edu	37	1	42915622	42915622	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:42915622C>A	uc001chj.2	-	2	489	c.219G>T	c.(217-219)CGG>CGT	p.R73R	ZMYND12_uc010ojt.1_Missense_Mutation_p.A21S	NM_032257	NP_115633	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12 isoform 1	73						intracellular	zinc ion binding			ovary(1)	1	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
CLDN19	149461	broad.mit.edu	37	1	43204130	43204130	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43204130C>T	uc001cht.1	-	2	541	c.350G>A	c.(349-351)CGT>CAT	p.R117H	CLDN19_uc001chu.2_Missense_Mutation_p.R117H|CLDN19_uc010ojv.1_Missense_Mutation_p.R117H	NM_148960	NP_683763	Q8N6F1	CLD19_HUMAN	claudin 19 isoform a	117	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|response to stimulus|visual perception	basolateral plasma membrane|integral to membrane|tight junction	identical protein binding				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
IPO13	9670	broad.mit.edu	37	1	44433043	44433043	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44433043C>T	uc001ckx.2	+	19	3465	c.2670C>T	c.(2668-2670)TTC>TTT	p.F890F	IPO13_uc001cky.2_Silent_p.F108F	NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	890					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)																---	---	---	---
HECTD3	79654	broad.mit.edu	37	1	45473119	45473119	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45473119C>T	uc009vxk.2	-	10	1567	c.1469G>A	c.(1468-1470)CGA>CAA	p.R490Q	HECTD3_uc001cmx.3_5'Flank|HECTD3_uc001cmy.3_Missense_Mutation_p.R100Q|HECTD3_uc010olh.1_Missense_Mutation_p.R206Q	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	490					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
NSUN4	387338	broad.mit.edu	37	1	46826501	46826501	+	Splice_Site	SNP	G	A	A	rs142333016	byFrequency;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46826501G>A	uc001cpr.1	+	5	987	c.878_splice	c.e5+1	p.A293_splice	NSUN4_uc010omc.1_Splice_Site_p.A244_splice|NSUN4_uc009vyf.1_Splice_Site_p.A142_splice|NSUN4_uc009vyg.1_Splice_Site_p.A244_splice|NSUN4_uc001cpt.1_Splice_Site|NSUN4_uc001cps.1_Splice_Site	NM_199044	NP_950245			NOL1/NOP2/Sun domain family 4 protein								methyltransferase activity				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
CYP4Z1	199974	broad.mit.edu	37	1	47564887	47564887	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47564887A>G	uc001cqu.1	+	8	1001	c.998A>G	c.(997-999)TAC>TGC	p.Y333C		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	333	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1																		---	---	---	---
ORC1L	4998	broad.mit.edu	37	1	52849543	52849543	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52849543G>A	uc001ctt.2	-	12	2041	c.1822C>T	c.(1822-1824)CGA>TGA	p.R608*	ORC1L_uc010oni.1_Nonsense_Mutation_p.R603*|ORC1L_uc001ctu.2_Nonsense_Mutation_p.R608*|ORC1L_uc009vzd.2_Nonsense_Mutation_p.R362*	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	608	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0																		---	---	---	---
PRPF38A	84950	broad.mit.edu	37	1	52870412	52870412	+	5'UTR	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52870412G>A	uc001ctv.3	+	1					ORC1L_uc001ctt.2_5'Flank|ORC1L_uc010oni.1_5'Flank|ORC1L_uc001ctu.2_5'Flank|ORC1L_uc009vzd.2_5'Flank|PRPF38A_uc001ctw.3_5'UTR	NM_032864	NP_116253			PRP38 pre-mRNA processing factor 38 (yeast)						mRNA processing|RNA splicing	spliceosomal complex					0																OREG0013487	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
DMRTB1	63948	broad.mit.edu	37	1	53925262	53925262	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53925262C>T	uc001cvq.1	+	1	191	c.136C>T	c.(136-138)CGC>TGC	p.R46C		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	46	DM.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2																		---	---	---	---
DNAJC6	9829	broad.mit.edu	37	1	65855087	65855087	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65855087C>A	uc001dcd.1	+	10	1335	c.1171C>A	c.(1171-1173)CTC>ATC	p.L391I	DNAJC6_uc001dcc.1_Missense_Mutation_p.L422I|DNAJC6_uc010opc.1_Missense_Mutation_p.L378I|DNAJC6_uc001dce.1_Missense_Mutation_p.L448I	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	391					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3																		---	---	---	---
SGIP1	84251	broad.mit.edu	37	1	67101641	67101641	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67101641C>T	uc001dcr.2	+	4	331	c.114C>T	c.(112-114)CAC>CAT	p.H38H		NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	38					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3																		---	---	---	---
C1orf141	400757	broad.mit.edu	37	1	67558859	67558859	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67558859A>G	uc001ddl.1	-	7	1143	c.1032T>C	c.(1030-1032)ACT>ACC	p.T344T	C1orf141_uc001ddm.1_Silent_p.T344T|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	344										ovary(1)	1																		---	---	---	---
AK5	26289	broad.mit.edu	37	1	77779512	77779512	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:77779512G>A	uc001dhn.2	+						AK5_uc001dho.2_Intron|AK5_uc001dhm.1_Silent_p.V220V	NM_174858	NP_777283			adenylate kinase 5 isoform 1						ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1																		---	---	---	---
SYDE2	84144	broad.mit.edu	37	1	85624662	85624662	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85624662T>A	uc009wcm.2	-	7	3405	c.3356A>T	c.(3355-3357)GAT>GTT	p.D1119V		NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	1119					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)														---	---	---	---
ODF2L	57489	broad.mit.edu	37	1	86820203	86820203	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86820203C>T	uc001dll.1	-						ODF2L_uc001dlm.1_Intron|ODF2L_uc001dln.2_Intron|ODF2L_uc001dlo.2_Intron|ODF2L_uc001dlp.2_Intron|ODF2L_uc010osg.1_Intron	NM_020729	NP_065780			outer dense fiber of sperm tails 2-like isoform							centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)														---	---	---	---
ZNF644	84146	broad.mit.edu	37	1	91404466	91404466	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91404466A>G	uc001dnw.2	-	3	2587	c.2445T>C	c.(2443-2445)TCT>TCC	p.S815S	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Silent_p.S815S	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	815					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)														---	---	---	---
CDC7	8317	broad.mit.edu	37	1	91985737	91985737	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91985737C>T	uc001doe.2	+	11	1396	c.1231C>T	c.(1231-1233)CGA>TGA	p.R411*	CDC7_uc001dof.2_Nonsense_Mutation_p.R411*|CDC7_uc010osw.1_Nonsense_Mutation_p.R383*|CDC7_uc009wdc.2_Nonsense_Mutation_p.R411*|CDC7_uc009wdd.2_Intron	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	411	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)														---	---	---	---
RPAP2	79871	broad.mit.edu	37	1	92767148	92767148	+	Splice_Site	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92767148G>A	uc001dot.2	+	3	343	c.234_splice	c.e3+1	p.C78_splice	RPAP2_uc009wdh.2_Splice_Site|GLMN_uc001dor.2_5'Flank|GLMN_uc009wdg.2_5'Flank|GLMN_uc001dos.2_5'Flank	NM_024813	NP_079089			RNA polymerase II associated protein 2							integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)														---	---	---	---
RPAP2	79871	broad.mit.edu	37	1	92789302	92789302	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92789302C>T	uc001dot.2	+	8	934	c.825C>T	c.(823-825)GGC>GGT	p.G275G	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	275						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)														---	---	---	---
EXTL2	2135	broad.mit.edu	37	1	101343423	101343423	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101343423C>A	uc001dtk.1	-	3	379	c.42G>T	c.(40-42)ATG>ATT	p.M14I	EXTL2_uc001dtl.1_Missense_Mutation_p.M14I|EXTL2_uc010ouk.1_Missense_Mutation_p.M1I|EXTL2_uc001dtm.1_Missense_Mutation_p.M14I	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	14	Cytoplasmic (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)														---	---	---	---
COL11A1	1301	broad.mit.edu	37	1	103427746	103427746	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:103427746G>A	uc001dul.2	-	40	3418	c.3100C>T	c.(3100-3102)CTT>TTT	p.L1034F	COL11A1_uc001duk.2_Missense_Mutation_p.L230F|COL11A1_uc001dum.2_Missense_Mutation_p.L1046F|COL11A1_uc001dun.2_Missense_Mutation_p.L995F|COL11A1_uc009weh.2_Missense_Mutation_p.L918F	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1034	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)														---	---	---	---
AMY1A	276	broad.mit.edu	37	1	104203067	104203067	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:104203067G>A	uc001duu.2	+	7	1178	c.964G>A	c.(964-966)GCT>ACT	p.A322T	AMY1A_uc001duv.2_Missense_Mutation_p.A322T	NM_001008221	NP_001008222	P04745	AMY1_HUMAN	salivary amylase alpha 1A precursor	322					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding|protein binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)														---	---	---	---
VAV3	10451	broad.mit.edu	37	1	108307782	108307782	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:108307782C>T	uc001dvk.1	-	9	891	c.837G>A	c.(835-837)GGG>GGA	p.G279G	VAV3_uc010ouw.1_Silent_p.G279G|VAV3_uc001dvl.1_Silent_p.G103G|VAV3_uc010oux.1_Silent_p.G279G	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	279	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)														---	---	---	---
CELSR2	1952	broad.mit.edu	37	1	109810580	109810580	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109810580C>T	uc001dxa.3	+	17	6277	c.6216C>T	c.(6214-6216)AGC>AGT	p.S2072S		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2072	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)														---	---	---	---
GNAI3	2773	broad.mit.edu	37	1	110121917	110121917	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110121917G>A	uc001dxz.2	+	4	552	c.395G>A	c.(394-396)CGA>CAA	p.R132Q		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	132					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)														---	---	---	---
HSD3B1	3283	broad.mit.edu	37	1	120054205	120054205	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120054205C>T	uc001ehv.1	+	3	370	c.225C>T	c.(223-225)GAC>GAT	p.D75D	HSD3B1_uc001ehw.2_Silent_p.D77D	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	75					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)													---	---	---	---
NBPF9	400818	broad.mit.edu	37	1	145075618	145075618	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145075618C>T	uc010oye.1	+						NBPF10_uc009wir.2_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001emh.2_Intron|PDE4DIP_uc001emk.2_Intron					RecName: Full=Neuroblastoma breakpoint family member 8;							cytoplasm					0																		---	---	---	---
ITGA10	8515	broad.mit.edu	37	1	145533915	145533915	+	Missense_Mutation	SNP	C	T	T	rs150141083		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145533915C>T	uc001eoa.2	+	13	1637	c.1561C>T	c.(1561-1563)CGT>TGT	p.R521C	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.R390C|ITGA10_uc009wiw.2_Missense_Mutation_p.R378C|ITGA10_uc010oyw.1_Missense_Mutation_p.R466C	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	521	FG-GAP 5.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity	p.R521H(1)		lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)																	---	---	---	---
PDZK1	5174	broad.mit.edu	37	1	145761219	145761219	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145761219G>A	uc001eon.1	+	8	1129	c.1032G>A	c.(1030-1032)CTG>CTA	p.L344L	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Silent_p.L344L|PDZK1_uc010oza.1_Silent_p.L233L	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	344					carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)															---	---	---	---
GJA8	2703	broad.mit.edu	37	1	147380700	147380700	+	Silent	SNP	C	T	T	rs148480116		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:147380700C>T	uc001epu.1	+	2	681	c.618C>T	c.(616-618)ATC>ATT	p.I206I		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	206	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)																	---	---	---	---
NBPF14	25832	broad.mit.edu	37	1	148009502	148009502	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:148009502A>C	uc001eqq.2	-	16	1822	c.1805T>G	c.(1804-1806)CTG>CGG	p.L602R	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Missense_Mutation_p.L175R|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	602	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)																	---	---	---	---
TMOD4	29765	broad.mit.edu	37	1	151143428	151143428	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151143428C>T	uc001exc.3	-	8	1028	c.838G>A	c.(838-840)GCC>ACC	p.A280T	TMOD4_uc001exb.2_Missense_Mutation_p.A108T|TMOD4_uc001exd.2_RNA|TMOD4_uc010pct.1_Missense_Mutation_p.A211T	NM_013353	NP_037485	Q9NZQ9	TMOD4_HUMAN	tropomodulin 4 (muscle)	280					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
RORC	6097	broad.mit.edu	37	1	151785790	151785790	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151785790G>A	uc001ezh.2	-	8	1207	c.1099C>T	c.(1099-1101)CGG>TGG	p.R367W	RORC_uc001ezg.2_Missense_Mutation_p.R346W|RORC_uc010pdo.1_Missense_Mutation_p.R421W|RORC_uc010pdp.1_Missense_Mutation_p.R367W	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	367	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
TCHH	7062	broad.mit.edu	37	1	152080509	152080509	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152080509C>A	uc001ezp.2	-	2	5184	c.5184G>T	c.(5182-5184)GAG>GAT	p.E1728D	TCHH_uc009wne.1_Missense_Mutation_p.E1728D	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1728	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
TCHH	7062	broad.mit.edu	37	1	152083351	152083351	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152083351C>T	uc001ezp.2	-	2	2342	c.2342G>A	c.(2341-2343)CGT>CAT	p.R781H	TCHH_uc009wne.1_Missense_Mutation_p.R781H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	781					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
CRNN	49860	broad.mit.edu	37	1	152382422	152382422	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152382422G>A	uc001ezx.2	-	3	1210	c.1136C>T	c.(1135-1137)ACG>ATG	p.T379M		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	379	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
PYGO2	90780	broad.mit.edu	37	1	154932143	154932143	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154932143C>T	uc001fft.2	-	3	539	c.333G>A	c.(331-333)GCG>GCA	p.A111A		NM_138300	NP_612157	Q9BRQ0	PYGO2_HUMAN	pygopus homolog 2	111	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			skin(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
DCST2	127579	broad.mit.edu	37	1	154999182	154999182	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154999182A>G	uc001fgm.2	-	9	1432	c.1352T>C	c.(1351-1353)TTG>TCG	p.L451S	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	451	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
TRIM46	80128	broad.mit.edu	37	1	155148109	155148109	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155148109G>A	uc001fhs.1	+	2	394	c.311G>A	c.(310-312)CGG>CAG	p.R104Q	RAG1AP1_uc010pey.1_Intron|KRTCAP2_uc001fho.2_5'Flank|KRTCAP2_uc001fhp.1_5'Flank|TRIM46_uc009wpe.1_RNA|TRIM46_uc010pez.1_Missense_Mutation_p.R91Q|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.R104Q|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Intron|TRIM46_uc001fhu.1_Missense_Mutation_p.R81Q|TRIM46_uc009wpg.1_Missense_Mutation_p.R91Q|TRIM46_uc009wpf.2_Missense_Mutation_p.R91Q|TRIM46_uc001fhv.3_Missense_Mutation_p.R91Q|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	104						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)															---	---	---	---
RAB25	57111	broad.mit.edu	37	1	156040014	156040014	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156040014G>A	uc001fnc.2	+	5	804	c.578G>A	c.(577-579)GGC>GAC	p.G193D		NM_020387	NP_065120	P57735	RAB25_HUMAN	RAB25	193					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)																	---	---	---	---
SEMA4A	64218	broad.mit.edu	37	1	156146488	156146488	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156146488G>T	uc001fnl.2	+	15	2090	c.1986G>T	c.(1984-1986)AAG>AAT	p.K662N	SEMA4A_uc009wrq.2_Missense_Mutation_p.K662N|SEMA4A_uc001fnm.2_Missense_Mutation_p.K662N|SEMA4A_uc001fnn.2_Missense_Mutation_p.K530N|SEMA4A_uc001fno.2_Missense_Mutation_p.K662N	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	662	Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)																	---	---	---	---
SMG5	23381	broad.mit.edu	37	1	156230293	156230293	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156230293G>A	uc001foc.3	-	15	2381	c.2232C>T	c.(2230-2232)CAC>CAT	p.H744H	SMG5_uc009wrv.2_Silent_p.H229H	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	744					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)																	---	---	---	---
IQGAP3	128239	broad.mit.edu	37	1	156513774	156513774	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156513774T>C	uc001fpf.2	-	22	2604	c.2529A>G	c.(2527-2529)TTA>TTG	p.L843L		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	843	IQ 4.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
BCAN	63827	broad.mit.edu	37	1	156618552	156618552	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156618552G>A	uc001fpp.2	+	6	1298	c.962G>A	c.(961-963)CGC>CAC	p.R321H	BCAN_uc001fpo.2_Missense_Mutation_p.R321H	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	321	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
OR10Z1	128368	broad.mit.edu	37	1	158576272	158576272	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158576272T>C	uc010pio.1	+	1	44	c.44T>C	c.(43-45)CTG>CCG	p.L15P		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)																	---	---	---	---
OR10J3	441911	broad.mit.edu	37	1	159284423	159284423	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159284423C>T	uc010piu.1	-	1	27	c.27G>A	c.(25-27)GTG>GTA	p.V9V		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)																	---	---	---	---
SLAMF9	89886	broad.mit.edu	37	1	159923100	159923100	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159923100G>C	uc001fus.2	-	2	507	c.390C>G	c.(388-390)TAC>TAG	p.Y130*	SLAMF9_uc009wtd.2_Nonsense_Mutation_p.Y130*|SLAMF9_uc001fut.2_Intron	NM_033438	NP_254273	Q96A28	SLAF9_HUMAN	SLAM family member 9 isoform 1	130	Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
PIGM	93183	broad.mit.edu	37	1	160001078	160001078	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160001078G>A	uc001fuv.1	-	1	706	c.452C>T	c.(451-453)GCC>GTC	p.A151V		NM_145167	NP_660150	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	151	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
ATP1A4	480	broad.mit.edu	37	1	160156137	160156137	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160156137T>G	uc001fve.3	+	21	3520	c.3041T>G	c.(3040-3042)CTC>CGC	p.L1014R	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.L517R|ATP1A4_uc001fvh.2_Missense_Mutation_p.L150R	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	1014	Cytoplasmic (Potential).			ITWWLCAIPYSILIFVYDEIRKLLIRQ -> WSFALTAQAG VKWRILGLLQPLPPRFK (in Ref. 6; BAC05228).	ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
LY9	4063	broad.mit.edu	37	1	160771611	160771611	+	Intron	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160771611C>A	uc001fwu.2	+						LY9_uc001fwt.2_Silent_p.V162V|LY9_uc010pjs.1_Intron|LY9_uc001fwv.2_Intron|LY9_uc001fww.2_Intron|LY9_uc001fwx.2_Intron|LY9_uc001fwy.1_Intron	NM_002348	NP_002339			lymphocyte antigen 9 isoform a						cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)															---	---	---	---
ARHGAP30	257106	broad.mit.edu	37	1	161019226	161019226	+	Silent	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161019226T>A	uc001fxl.2	-	11	2020	c.1674A>T	c.(1672-1674)GGA>GGT	p.G558G	ARHGAP30_uc001fxk.2_Silent_p.G558G|ARHGAP30_uc001fxm.2_Silent_p.G404G|ARHGAP30_uc009wtx.2_Silent_p.G231G|ARHGAP30_uc001fxn.1_Silent_p.G404G	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	558					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)															---	---	---	---
NR1I3	9970	broad.mit.edu	37	1	161203117	161203117	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161203117C>T	uc001fzx.2	-	4	453	c.250G>A	c.(250-252)GCA>ACA	p.A84T	TOMM40L_uc009wuf.1_Intron|NR1I3_uc001fzf.2_Missense_Mutation_p.A84T|NR1I3_uc001fzg.2_Missense_Mutation_p.A55T|NR1I3_uc001fzh.2_Missense_Mutation_p.A55T|NR1I3_uc001fzi.2_Missense_Mutation_p.A55T|NR1I3_uc001fzj.2_Missense_Mutation_p.A55T|NR1I3_uc001fzk.2_Missense_Mutation_p.A55T|NR1I3_uc001fzl.2_Missense_Mutation_p.A55T|NR1I3_uc001fzm.2_Missense_Mutation_p.A9T|NR1I3_uc001fzn.2_Intron|NR1I3_uc009wug.2_5'UTR|NR1I3_uc001fzp.2_Missense_Mutation_p.A84T|NR1I3_uc001fzo.2_Intron|NR1I3_uc001fzq.2_Intron|NR1I3_uc001fzr.2_Intron|NR1I3_uc001fzs.2_Intron|NR1I3_uc001fzt.2_Intron|NR1I3_uc001fzu.2_Intron|NR1I3_uc001fzv.2_Intron|NR1I3_uc001fzw.2_Missense_Mutation_p.A84T|NR1I3_uc001fzy.2_Missense_Mutation_p.A84T|NR1I3_uc001fzz.2_Missense_Mutation_p.A84T|NR1I3_uc001gaa.2_Missense_Mutation_p.A84T|NR1I3_uc001gab.2_Missense_Mutation_p.A84T|NR1I3_uc001gac.2_Missense_Mutation_p.A55T|NR1I3_uc010pkm.1_Missense_Mutation_p.A55T|NR1I3_uc010pkn.1_Missense_Mutation_p.A84T	NM_001077480	NP_001070948	Q14994	NR1I3_HUMAN	constitutive androstane receptor isoform 2	84					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(1)|skin(1)	2	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)															---	---	---	---
MPZ	4359	broad.mit.edu	37	1	161276654	161276654	+	Missense_Mutation	SNP	G	A	A	rs121913590		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161276654G>A	uc001gaf.3	-	3	359	c.322C>T	c.(322-324)CGC>TGC	p.R108C	MPZ_uc010pko.1_RNA	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero	98	Ig-like V-type.|Extracellular (Potential).		R -> P (in CMT1B).|R -> C (in CMT1B; severe and DSS).|R -> H (in CMT1B).|R -> S (in CMT1B).		synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)															---	---	---	---
FCRLA	84824	broad.mit.edu	37	1	161681777	161681777	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161681777G>T	uc001gbe.2	+	5	864	c.622G>T	c.(622-624)GGA>TGA	p.G208*	FCRLA_uc001gbd.2_Nonsense_Mutation_p.G202*|FCRLA_uc001gbf.2_Nonsense_Mutation_p.G113*|FCRLA_uc001gbg.2_Nonsense_Mutation_p.G62*|FCRLA_uc009wuo.2_Nonsense_Mutation_p.G68*|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	185	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)															---	---	---	---
OLFML2B	25903	broad.mit.edu	37	1	161989931	161989931	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161989931G>A	uc001gbu.2	-	2	640	c.216C>T	c.(214-216)GGC>GGT	p.G72G	OLFML2B_uc010pkq.1_Silent_p.G72G	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	72										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)															---	---	---	---
SLC9A11	284525	broad.mit.edu	37	1	173551081	173551081	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173551081G>A	uc001giz.2	-	7	1130	c.707C>T	c.(706-708)GCA>GTA	p.A236V	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	236	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2																		---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176640157	176640157	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176640157T>C	uc001gkz.2	+	4	3207	c.2043T>C	c.(2041-2043)ACT>ACC	p.T681T	PAPPA2_uc001gky.1_Silent_p.T681T|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	681	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
QSOX1	5768	broad.mit.edu	37	1	180165497	180165497	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180165497C>T	uc001gnz.2	+	12	1644	c.1569C>T	c.(1567-1569)GAC>GAT	p.D523D	QSOX1_uc001gny.2_Silent_p.D523D|QSOX1_uc001goa.2_Silent_p.D523D|QSOX1_uc001goc.2_Silent_p.D65D|FLJ23867_uc001god.3_5'Flank	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	523					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ACBD6	84320	broad.mit.edu	37	1	180471273	180471273	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180471273G>A	uc001gog.2	-	1	750	c.129C>T	c.(127-129)GCC>GCT	p.A43A		NM_032360	NP_115736	Q9BR61	ACBD6_HUMAN	acyl-coenzyme A binding domain containing 6	43	ACB.					cytoplasm|nucleus	fatty-acyl-CoA binding			ovary(1)	1																		---	---	---	---
STX6	10228	broad.mit.edu	37	1	180945780	180945780	+	Missense_Mutation	SNP	G	A	A	rs114031596	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180945780G>A	uc010pnq.1	-	8	931	c.694C>T	c.(694-696)CGG>TGG	p.R232W	STX6_uc009wxo.1_5'Flank|STX6_uc001goo.2_Missense_Mutation_p.R232W|STX6_uc010pnr.1_Missense_Mutation_p.R131W	NM_005819	NP_005810	O43752	STX6_HUMAN	syntaxin 6	232	Cytoplasmic (Potential).				Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			ovary(1)	1																		---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181453073	181453073	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181453073G>A	uc001gow.2	+	1	358	c.193G>A	c.(193-195)GTC>ATC	p.V65I		NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	65	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6																		---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181767624	181767624	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181767624C>A	uc001gow.2	+	47	6632	c.6467C>A	c.(6466-6468)GCT>GAT	p.A2156D	CACNA1E_uc009wxs.2_Missense_Mutation_p.A2044D|CACNA1E_uc009wxt.2_Missense_Mutation_p.A1425D	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2199	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6																		---	---	---	---
ZNF648	127665	broad.mit.edu	37	1	182026561	182026561	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:182026561C>T	uc001goz.2	-	2	793	c.585G>A	c.(583-585)CCG>CCA	p.P195P		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
RNASEL	6041	broad.mit.edu	37	1	182555115	182555115	+	Missense_Mutation	SNP	G	T	T	rs145415894		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:182555115G>T	uc001gpj.1	-	1	994	c.827C>A	c.(826-828)GCA>GAA	p.A276E	RNASEL_uc009wxz.1_Missense_Mutation_p.A276E|RNASEL_uc001gpk.2_Missense_Mutation_p.A276E|RNASEL_uc009wya.1_Missense_Mutation_p.A276E	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	276	ANK 8.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5														Hereditary_Prostate_Cancer				---	---	---	---
EDEM3	80267	broad.mit.edu	37	1	184677410	184677410	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:184677410C>T	uc010pok.1	-	17	2175	c.1914G>A	c.(1912-1914)CAG>CAA	p.Q638Q	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Silent_p.Q638Q	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	638					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1																		---	---	---	---
F13B	2165	broad.mit.edu	37	1	197026436	197026436	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197026436G>A	uc001gtt.1	-	6	1009	c.965C>T	c.(964-966)ACA>ATA	p.T322I		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	322	Sushi 5.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
KLHL12	59349	broad.mit.edu	37	1	202894140	202894140	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202894140G>A	uc001gyo.1	-	2	351	c.151C>T	c.(151-153)CTG>TTG	p.L51L	KLHL12_uc010pqc.1_Silent_p.L89L|KLHL12_uc009xah.1_Silent_p.L51L	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	51	BTB.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)															---	---	---	---
ADORA1	134	broad.mit.edu	37	1	203098114	203098114	+	Missense_Mutation	SNP	G	A	A	rs2275349		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203098114G>A	uc001gze.1	+	3	578	c.145G>A	c.(145-147)GTG>ATG	p.V49M	ADORA1_uc001gzf.1_Missense_Mutation_p.V49M|ADORA1_uc010pqg.1_Translation_Start_Site|ADORA1_uc009xak.1_Translation_Start_Site|ADORA1_uc010pqh.1_Missense_Mutation_p.V82M	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	49	Helical; Name=2; (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)													---	---	---	---
FMOD	2331	broad.mit.edu	37	1	203311596	203311596	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203311596C>T	uc001gzr.2	-	3	1142	c.1006G>A	c.(1006-1008)GTG>ATG	p.V336M	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	336					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)													OREG0014119	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FMOD	2331	broad.mit.edu	37	1	203316578	203316578	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203316578C>T	uc001gzr.2	-	2	957	c.821G>A	c.(820-822)CGG>CAG	p.R274Q	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	274	LRR 8.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)															---	---	---	---
REN	5972	broad.mit.edu	37	1	204131189	204131189	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204131189C>T	uc001haq.2	-	2	245	c.201G>A	c.(199-201)CTG>CTA	p.L67L		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	67					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)													---	---	---	---
NFASC	23114	broad.mit.edu	37	1	204948583	204948583	+	Missense_Mutation	SNP	G	A	A	rs151110151	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204948583G>A	uc001hbj.2	+	19	2400	c.2072G>A	c.(2071-2073)CGG>CAG	p.R691Q	NFASC_uc010pra.1_Missense_Mutation_p.R687Q|NFASC_uc001hbi.2_Missense_Mutation_p.R687Q|NFASC_uc010prb.1_Missense_Mutation_p.R702Q|NFASC_uc010prc.1_Missense_Mutation_p.R258Q|NFASC_uc001hbk.1_Missense_Mutation_p.R497Q|NFASC_uc001hbl.1_5'Flank	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	691	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)															---	---	---	---
CNTN2	6900	broad.mit.edu	37	1	205034993	205034993	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205034993C>T	uc001hbr.2	+	14	2041	c.1772C>T	c.(1771-1773)ACG>ATG	p.T591M	CNTN2_uc001hbq.1_Missense_Mutation_p.T482M|CNTN2_uc001hbs.2_Missense_Mutation_p.T379M	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	591	Ig-like C2-type 6.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)															---	---	---	---
CR1	1378	broad.mit.edu	37	1	207753935	207753935	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207753935G>T	uc001hfy.2	+	23	3983	c.3843G>T	c.(3841-3843)AAG>AAT	p.K1281N	CR1_uc009xcl.1_Missense_Mutation_p.K831N|CR1_uc001hfx.2_Missense_Mutation_p.K1731N	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1281	Sushi 20.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3																		---	---	---	---
CR1	1378	broad.mit.edu	37	1	207785031	207785031	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207785031C>T	uc001hfy.2	+	30	5095	c.4955C>T	c.(4954-4956)CCG>CTG	p.P1652L	CR1_uc001hfx.2_Missense_Mutation_p.P2102L	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1652	Sushi 26.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3																		---	---	---	---
LAMB3	3914	broad.mit.edu	37	1	209799235	209799235	+	Silent	SNP	G	A	A	rs138710333		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209799235G>A	uc001hhg.2	-	13	2124	c.1734C>T	c.(1732-1734)TGC>TGT	p.C578C	LAMB3_uc009xco.2_Silent_p.C578C|LAMB3_uc001hhh.2_Silent_p.C578C|LAMB3_uc010psl.1_Intron|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	578	Laminin EGF-like 6.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)														---	---	---	---
RPS6KC1	26750	broad.mit.edu	37	1	213414588	213414588	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213414588T>G	uc010ptr.1	+	11	1928	c.1769T>G	c.(1768-1770)CTC>CGC	p.L590R	RPS6KC1_uc001hkd.2_Missense_Mutation_p.L578R|RPS6KC1_uc010pts.1_Missense_Mutation_p.L378R|RPS6KC1_uc010ptt.1_Missense_Mutation_p.L378R|RPS6KC1_uc010ptu.1_Missense_Mutation_p.L409R|RPS6KC1_uc010ptv.1_Missense_Mutation_p.L125R|RPS6KC1_uc001hke.2_Missense_Mutation_p.L409R	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	590					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)														---	---	---	---
EPRS	2058	broad.mit.edu	37	1	220145457	220145457	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220145457A>G	uc001hly.1	-	30	4547	c.4277T>C	c.(4276-4278)GTG>GCG	p.V1426A		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1426	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)													---	---	---	---
BPNT1	10380	broad.mit.edu	37	1	220246279	220246279	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220246279C>A	uc001hma.2	-	4	418	c.246G>T	c.(244-246)GTG>GTT	p.V82V	BPNT1_uc010pug.1_Silent_p.V27V|BPNT1_uc010puh.1_Intron|BPNT1_uc001hmb.3_Silent_p.V82V	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	82					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)														---	---	---	---
TP53BP2	7159	broad.mit.edu	37	1	223986208	223986208	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223986208C>T	uc010pvb.1	-	12	1949	c.1657G>A	c.(1657-1659)GCA>ACA	p.A553T	TP53BP2_uc001hod.2_Missense_Mutation_p.A424T|TP53BP2_uc010puz.1_Intron|TP53BP2_uc010pva.1_Missense_Mutation_p.A192T	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	547					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)														---	---	---	---
TMEM63A	9725	broad.mit.edu	37	1	226048598	226048598	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226048598C>T	uc001hpm.1	-	14	1435	c.1185G>A	c.(1183-1185)TGG>TGA	p.W395*		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	395						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)																	---	---	---	---
PSEN2	5664	broad.mit.edu	37	1	227079049	227079049	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227079049C>T	uc009xeo.1	+	10	1384	c.957C>T	c.(955-957)TAC>TAT	p.Y319Y	PSEN2_uc009xep.1_Silent_p.Y319Y|PSEN2_uc001hqk.2_RNA	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	319	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228494756	228494756	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228494756G>A	uc009xez.1	+	45	12125	c.12081G>A	c.(12079-12081)GTG>GTA	p.V4027V	OBSCN_uc001hsn.2_Silent_p.V4027V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4027	Ig-like 41.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
TRIM67	440730	broad.mit.edu	37	1	231349596	231349596	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231349596G>A	uc009xfn.1	+	9	2201	c.2159G>A	c.(2158-2160)GGC>GAC	p.G720D		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	720	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)																---	---	---	---
PCNXL2	80003	broad.mit.edu	37	1	233134036	233134036	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233134036G>A	uc001hvl.2	-	32	5987	c.5752C>T	c.(5752-5754)CAG>TAG	p.Q1918*	PCNXL2_uc001hvk.1_Nonsense_Mutation_p.Q570*|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1918						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)																---	---	---	---
TARBP1	6894	broad.mit.edu	37	1	234601428	234601428	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:234601428C>T	uc001hwd.2	-	5	1275	c.1275G>A	c.(1273-1275)GCG>GCA	p.A425A		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	425					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)															---	---	---	---
B3GALNT2	148789	broad.mit.edu	37	1	235634232	235634232	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235634232C>T	uc001hxc.2	-	6	923	c.694G>A	c.(694-696)GGC>AGC	p.G232S	B3GALNT2_uc001hxd.1_Missense_Mutation_p.G273S	NM_152490	NP_689703	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	232	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			breast(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)															---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237729972	237729972	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237729972C>T	uc001hyl.1	+	28	3440	c.3320C>T	c.(3319-3321)ACG>ATG	p.T1107M		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1107	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
ZNF669	79862	broad.mit.edu	37	1	247263838	247263838	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247263838A>G	uc001ice.2	-	4	1406	c.1233T>C	c.(1231-1233)ATT>ATC	p.I411I	ZNF669_uc001icf.2_Silent_p.I325I	NM_024804	NP_079080	Q96BR6	ZN669_HUMAN	zinc finger protein 669 isoform 1	411	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;4.09e-05)|all_epithelial(71;6.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0283)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00427)															---	---	---	---
PXDN	7837	broad.mit.edu	37	2	1653138	1653138	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1653138G>A	uc002qxa.2	-	17	2478	c.2414C>T	c.(2413-2415)ACG>ATG	p.T805M		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	805					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)														---	---	---	---
IAH1	285148	broad.mit.edu	37	2	9628458	9628458	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:9628458G>A	uc002qzr.2	+	6	773	c.747G>A	c.(745-747)TAG>TAA	p.*249*	IAH1_uc002qzs.2_Silent_p.*136*|IAH1_uc002qzt.2_Silent_p.*136*|IAH1_uc010yiz.1_RNA	NM_001039613	NP_001034702	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog	249					lipid catabolic process		hydrolase activity, acting on ester bonds				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
WDR35	57539	broad.mit.edu	37	2	20173395	20173395	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20173395C>T	uc002rdi.2	-	8	919	c.811G>A	c.(811-813)GCA>ACA	p.A271T	WDR35_uc002rdj.2_Missense_Mutation_p.A271T|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_5'UTR	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	271										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
WDR35	57539	broad.mit.edu	37	2	20175418	20175418	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20175418C>T	uc002rdi.2	-	6	551	c.443G>A	c.(442-444)CGT>CAT	p.R148H	WDR35_uc002rdj.2_Missense_Mutation_p.R148H|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_5'UTR	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	148	WD 3.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
RHOB	388	broad.mit.edu	37	2	20647251	20647251	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20647251G>C	uc002rdv.2	+	1	417	c.25G>C	c.(25-27)GTG>CTG	p.V9L		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	9					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)														---	---	---	---
ASXL2	55252	broad.mit.edu	37	2	25966441	25966441	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25966441G>A	uc002rgs.2	-	12	2986	c.2765C>T	c.(2764-2766)GCA>GTA	p.A922V	ASXL2_uc002rgt.1_Intron	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	922					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
EIF2B4	8890	broad.mit.edu	37	2	27591927	27591927	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27591927G>A	uc002rkb.2	-	4	507	c.364C>T	c.(364-366)CAA>TAA	p.Q122*	EIF2B4_uc002rjz.2_Nonsense_Mutation_p.Q142*|EIF2B4_uc002rka.2_Nonsense_Mutation_p.Q107*|EIF2B4_uc002rkc.2_Nonsense_Mutation_p.Q121*|EIF2B4_uc002rkd.2_5'UTR|EIF2B4_uc002rke.2_Nonsense_Mutation_p.Q91*|EIF2B4_uc002rkf.1_Nonsense_Mutation_p.Q91*|SNX17_uc010ylj.1_5'Flank|SNX17_uc002rkg.1_5'Flank|SNX17_uc010ylk.1_5'Flank|SNX17_uc010eza.1_5'Flank|SNX17_uc002rki.1_5'Flank|SNX17_uc002rkh.1_5'Flank|SNX17_uc010yll.1_5'Flank|SNX17_uc010ylm.1_5'Flank|SNX17_uc010yln.1_5'Flank|SNX17_uc010ylo.1_5'Flank|SNX17_uc010ylp.1_5'Flank|SNX17_uc010ylq.1_5'Flank	NM_001034116	NP_001029288	Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B,	122					myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
IFT172	26160	broad.mit.edu	37	2	27703942	27703942	+	Silent	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27703942G>C	uc002rku.2	-	8	807	c.756C>G	c.(754-756)GGC>GGG	p.G252G	IFT172_uc002rkw.2_Silent_p.G252G|IFT172_uc010yls.1_Silent_p.G231G|IFT172_uc010ezc.2_Silent_p.G252G|IFT172_uc002rkv.2_Silent_p.G252G	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	252	WD 6.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
TRMT61B	55006	broad.mit.edu	37	2	29074131	29074131	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:29074131A>G	uc002rmm.2	-	5	1151	c.1119T>C	c.(1117-1119)ATT>ATC	p.I373I	TRMT61B_uc002rmn.2_Silent_p.I373I|TRMT61B_uc010ezk.2_Intron	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	373							tRNA (adenine-N1-)-methyltransferase activity				0																		---	---	---	---
GALNT14	79623	broad.mit.edu	37	2	31135133	31135133	+	Missense_Mutation	SNP	C	T	T	rs149431826		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31135133C>T	uc002rnr.2	-	14	2075	c.1456G>A	c.(1456-1458)GCC>ACC	p.A486T	GALNT14_uc002rnq.2_Missense_Mutation_p.A466T|GALNT14_uc002rns.2_Missense_Mutation_p.A491T|GALNT14_uc010ymr.1_Missense_Mutation_p.A451T	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	486	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
GALNT14	79623	broad.mit.edu	37	2	31152322	31152322	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31152322C>A	uc002rnr.2	-	11	1709	c.1090G>T	c.(1090-1092)GAT>TAT	p.D364Y	GALNT14_uc002rnq.2_Missense_Mutation_p.D344Y|GALNT14_uc002rns.2_Missense_Mutation_p.D369Y|GALNT14_uc010ymr.1_Missense_Mutation_p.D329Y|GALNT14_uc010ezo.1_Missense_Mutation_p.D331Y	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	364	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
XDH	7498	broad.mit.edu	37	2	31560668	31560668	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31560668G>A	uc002rnv.1	-	35	3869	c.3790C>T	c.(3790-3792)CCC>TCC	p.P1264S		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1264					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)													---	---	---	---
XDH	7498	broad.mit.edu	37	2	31570415	31570415	+	Silent	SNP	G	A	A	rs45562835		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31570415G>A	uc002rnv.1	-	29	3328	c.3249C>T	c.(3247-3249)AGC>AGT	p.S1083S		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1083					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)													---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32703728	32703728	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32703728C>T	uc010ezu.2	+	36	7228	c.7094C>T	c.(7093-7095)ACG>ATG	p.T2365M		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2365					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
STRN	6801	broad.mit.edu	37	2	37152258	37152258	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37152258T>C	uc002rpn.2	-	2	337	c.328A>G	c.(328-330)AAA>GAA	p.K110E	STRN_uc010ezx.2_Missense_Mutation_p.K110E	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	110	Potential.				dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)																---	---	---	---
CYP1B1	1545	broad.mit.edu	37	2	38298092	38298092	+	Missense_Mutation	SNP	G	A	A	rs28936701		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38298092G>A	uc002rqo.2	-	4	1808	c.1405C>T	c.(1405-1407)CGG>TGG	p.R469W		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	469					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)													---	---	---	---
HNRPLL	92906	broad.mit.edu	37	2	38811076	38811076	+	Intron	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38811076G>T	uc002rqw.2	-						HNRPLL_uc002rqv.2_5'Flank|HNRPLL_uc002rqx.2_Intron	NM_138394	NP_612403			heterogeneous nuclear ribonucleoprotein L-like						mRNA processing|positive regulation of RNA splicing	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			skin(1)	1		all_hematologic(82;0.248)																---	---	---	---
EPCAM	4072	broad.mit.edu	37	2	47607055	47607055	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:47607055A>G	uc002rvx.2	+	7	1163	c.805A>G	c.(805-807)ATT>GTT	p.I269V	EPCAM_uc002rvw.2_Missense_Mutation_p.I297V	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	269	Helical; (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1														Lynch_syndrome				---	---	---	---
ASB3	51130	broad.mit.edu	37	2	53927628	53927628	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:53927628A>G	uc002rxg.1	-	8	1153	c.1018T>C	c.(1018-1020)TAT>CAT	p.Y340H	ASB3_uc002rxh.1_Missense_Mutation_p.Y267H|ASB3_uc002rxi.3_Missense_Mutation_p.Y378H|ASB3_uc002rxf.1_RNA	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	340	ANK 10.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
CCDC85A	114800	broad.mit.edu	37	2	56603069	56603069	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:56603069A>G	uc002rzn.2	+	5	2073	c.1571A>G	c.(1570-1572)AAG>AGG	p.K524R		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	524										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)															---	---	---	---
KIAA1841	84542	broad.mit.edu	37	2	61343153	61343153	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61343153A>G	uc002saw.3	+	17	2087	c.1784A>G	c.(1783-1785)AAA>AGA	p.K595R	KIAA1841_uc002sax.3_Missense_Mutation_p.K449R|KIAA1841_uc002say.2_Missense_Mutation_p.K595R	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	595											0			Epithelial(17;0.193)															---	---	---	---
USP34	9736	broad.mit.edu	37	2	61575028	61575028	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61575028G>A	uc002sbe.2	-	15	2284	c.2262C>T	c.(2260-2262)CAC>CAT	p.H754H		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	754					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)															---	---	---	---
FAM161A	84140	broad.mit.edu	37	2	62067454	62067454	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:62067454G>A	uc010ypo.1	-	3	787	c.685C>T	c.(685-687)CGA>TGA	p.R229*	FAM161A_uc002sbm.3_Nonsense_Mutation_p.R229*|FAM161A_uc002sbn.3_Nonsense_Mutation_p.R39*|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Nonsense_Mutation_p.R120*	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	229					response to stimulus|visual perception	centrosome		p.R229W(1)		large_intestine(2)|ovary(1)	3																		---	---	---	---
PROKR1	10887	broad.mit.edu	37	2	68882693	68882693	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:68882693C>T	uc010yqj.1	+	2	1167	c.1167C>T	c.(1165-1167)TGC>TGT	p.C389C	PROKR1_uc002ses.2_RNA	NM_138964	NP_620414	Q8TCW9	PKR1_HUMAN	G protein-coupled receptor 73	389	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(1)	1																		---	---	---	---
GKN1	56287	broad.mit.edu	37	2	69204842	69204842	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:69204842A>C	uc002sfc.2	+	3	245	c.182A>C	c.(181-183)AAT>ACT	p.N61T		NM_019617	NP_062563	Q9NS71	GKN1_HUMAN	18 kDa antrum mucosa protein precursor	61					digestion|positive regulation of cell division	extracellular region				breast(1)	1																		---	---	---	---
CYP26B1	56603	broad.mit.edu	37	2	72371250	72371250	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:72371250C>T	uc002sih.1	-	2	297	c.297G>A	c.(295-297)GCG>GCA	p.A99A	CYP26B1_uc010yra.1_Silent_p.A82A|CYP26B1_uc010yrb.1_Intron	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	99					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2																		---	---	---	---
ALMS1	7840	broad.mit.edu	37	2	73677405	73677405	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73677405C>T	uc002sje.1	+	10	3865	c.3754C>T	c.(3754-3756)CAG>TAG	p.Q1252*	ALMS1_uc002sjf.1_Nonsense_Mutation_p.Q1208*|ALMS1_uc002sjg.2_Nonsense_Mutation_p.Q638*|ALMS1_uc002sjh.1_Nonsense_Mutation_p.Q638*	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1250	16.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9																		---	---	---	---
ALMS1	7840	broad.mit.edu	37	2	73784458	73784458	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73784458A>G	uc002sje.1	+	16	10304	c.10193A>G	c.(10192-10194)GAA>GGA	p.E3398G	ALMS1_uc002sjf.1_Missense_Mutation_p.E3354G|ALMS1_uc002sjg.2_Missense_Mutation_p.E2784G|ALMS1_uc002sjh.1_Missense_Mutation_p.E2784G|ALMS1_uc010fev.1_Missense_Mutation_p.E156G	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3396					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9																		---	---	---	---
HTRA2	27429	broad.mit.edu	37	2	74757166	74757166	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74757166C>T	uc002smi.1	+	1	635	c.33C>T	c.(31-33)GGC>GGT	p.G11G	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Silent_p.G11G|HTRA2_uc002smk.1_Silent_p.G11G|HTRA2_uc002sml.1_Silent_p.G11G|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	11					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1																		---	---	---	---
SUCLG1	8802	broad.mit.edu	37	2	84660507	84660507	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84660507C>T	uc002son.2	-	6	835	c.642G>A	c.(640-642)ACG>ACA	p.T214T	SUCLG1_uc010ysk.1_Silent_p.T201T	NM_003849	NP_003840	P53597	SUCA_HUMAN	succinate-CoA ligase, GDP-forming alpha subunit	214					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)													---	---	---	---
ST3GAL5	8869	broad.mit.edu	37	2	86075232	86075232	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86075232G>A	uc002sqq.1	-	4	543	c.414C>T	c.(412-414)AGC>AGT	p.S138S	ST3GAL5_uc010fgq.1_Silent_p.S10S|ST3GAL5_uc002sqp.1_Silent_p.S115S	NM_003896	NP_003887	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	138	Lumenal (Potential).				ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity				0																		---	---	---	---
SMYD1	150572	broad.mit.edu	37	2	88390622	88390622	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:88390622A>C	uc002ssr.2	+	4	622	c.620A>C	c.(619-621)GAC>GCC	p.D207A	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_5'UTR	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	207	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
PDCL3	79031	broad.mit.edu	37	2	101192940	101192940	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101192940C>T	uc002tao.2	+	6	814	c.702C>T	c.(700-702)AGC>AGT	p.S234S		NM_024065	NP_076970	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	234					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding				0																		---	---	---	---
MAP4K4	9448	broad.mit.edu	37	2	102499030	102499030	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102499030C>T	uc002tbg.2	+	25	3023	c.2968C>T	c.(2968-2970)CGT>TGT	p.R990C	MAP4K4_uc002tbc.2_Missense_Mutation_p.R1071C|MAP4K4_uc002tbd.2_Missense_Mutation_p.R963C|MAP4K4_uc002tbe.2_Missense_Mutation_p.R909C|MAP4K4_uc002tbf.2_Missense_Mutation_p.R1024C|MAP4K4_uc010yvy.1_Missense_Mutation_p.R986C|MAP4K4_uc002tbh.2_Missense_Mutation_p.R908C|MAP4K4_uc002tbi.2_Missense_Mutation_p.R793C|MAP4K4_uc010yvz.1_Missense_Mutation_p.R1030C|MAP4K4_uc002tbk.2_Missense_Mutation_p.R445C|MAP4K4_uc002tbl.2_Missense_Mutation_p.R176C	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	990	CNH.|Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
GPR45	11250	broad.mit.edu	37	2	105858406	105858406	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:105858406G>A	uc002tco.1	+	1	207	c.91G>A	c.(91-93)GCA>ACA	p.A31T		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	31	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3																		---	---	---	---
GCC2	9648	broad.mit.edu	37	2	109088059	109088059	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109088059G>A	uc002tec.2	+	6	2428	c.2274G>A	c.(2272-2274)CAG>CAA	p.Q758Q	GCC2_uc002ted.2_Silent_p.Q657Q	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	758	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1																		---	---	---	---
ANKRD57	65124	broad.mit.edu	37	2	110373584	110373584	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:110373584A>G	uc002tfb.2	+	1	1674	c.1518A>G	c.(1516-1518)GAA>GAG	p.E506E	SEPT10_uc010ywu.1_5'Flank|SEPT10_uc002tew.2_5'Flank|SEPT10_uc002tex.2_5'Flank|SEPT10_uc002tey.2_5'Flank|SEPT10_uc010ywv.1_5'Flank	NM_023016	NP_075392	Q53LP3	ANR57_HUMAN	ankyrin repeat domain 57	506											0																		---	---	---	---
ACOXL	55289	broad.mit.edu	37	2	111556607	111556607	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:111556607C>T	uc002tgr.3	+	7	701	c.477C>T	c.(475-477)ATC>ATT	p.I159I	ACOXL_uc010fkc.2_Silent_p.I159I|ACOXL_uc010yxk.1_Silent_p.I159I	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	159					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112608394	112608394	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112608394T>C	uc002thi.2	-	14	1856	c.1609A>G	c.(1609-1611)ACT>GCT	p.T537A		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	537					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112614259	112614259	+	Intron	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112614259A>T	uc002thi.2	-							NM_022662	NP_073153			anaphase promoting complex subunit 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
IL1F8	27177	broad.mit.edu	37	2	113788675	113788675	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113788675A>G	uc002tiq.1	-	3	175	c.71T>C	c.(70-72)CTG>CCG	p.L24P	IL1F8_uc002tir.1_Missense_Mutation_p.L24P	NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	24					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1																		---	---	---	---
EPB41L5	57669	broad.mit.edu	37	2	120885423	120885423	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120885423T>C	uc002tmg.2	+	17	1623	c.1497T>C	c.(1495-1497)TAT>TAC	p.Y499Y	EPB41L5_uc010fll.2_Silent_p.Y499Y|EPB41L5_uc010flm.2_Silent_p.Y303Y	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	499						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1																		---	---	---	---
TFCP2L1	29842	broad.mit.edu	37	2	121992863	121992863	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:121992863C>T	uc002tmx.2	-	11	1121	c.1028G>A	c.(1027-1029)CGA>CAA	p.R343Q	TFCP2L1_uc010flr.2_Missense_Mutation_p.R343Q|TFCP2L1_uc010flq.2_5'Flank	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	343					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)																	---	---	---	---
GPR17	2840	broad.mit.edu	37	2	128408876	128408876	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128408876C>A	uc010yzn.1	+	4	1262	c.651C>A	c.(649-651)GCC>GCA	p.A217A	LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.A217A|GPR17_uc010yzo.1_Silent_p.A189A|GPR17_uc002tpd.2_Silent_p.A189A	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	217	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)														---	---	---	---
TUBA3D	113457	broad.mit.edu	37	2	132240222	132240222	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132240222C>T	uc002tsu.3	+	5	1261	c.1154C>T	c.(1153-1155)GCG>GTG	p.A385V		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	385					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)														---	---	---	---
ZRANB3	84083	broad.mit.edu	37	2	136107605	136107605	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136107605G>A	uc002tum.2	-	5	657	c.540C>T	c.(538-540)GCC>GCT	p.A180A	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Silent_p.A180A|ZRANB3_uc002tun.1_Silent_p.A120A	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	180	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)														---	---	---	---
GTDC1	79712	broad.mit.edu	37	2	144966324	144966324	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:144966324A>G	uc002tvp.2	-	4	304	c.25T>C	c.(25-27)TTC>CTC	p.F9L	GTDC1_uc002tvo.2_Missense_Mutation_p.F9L|GTDC1_uc002tvq.2_Missense_Mutation_p.F9L|GTDC1_uc002tvr.2_Missense_Mutation_p.F9L|GTDC1_uc010fnn.2_Missense_Mutation_p.F9L|GTDC1_uc002tvs.2_5'UTR|GTDC1_uc010fno.2_Intron|GTDC1_uc002tvt.1_Missense_Mutation_p.F9L	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	9					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)														---	---	---	---
TNFAIP6	7130	broad.mit.edu	37	2	152220548	152220548	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152220548C>T	uc002txk.2	+	2	262	c.186C>T	c.(184-186)GGC>GGT	p.G62G		NM_007115	NP_009046	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	62	Link.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)														---	---	---	---
FAP	2191	broad.mit.edu	37	2	163030235	163030235	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163030235T>C	uc002ucd.2	-	23	2240	c.2032A>G	c.(2032-2034)AAG>GAG	p.K678E	FAP_uc010fpc.2_Missense_Mutation_p.K227E|FAP_uc010zct.1_Missense_Mutation_p.K653E|FAP_uc010fpd.2_Missense_Mutation_p.K157E	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	678	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3																		---	---	---	---
IFIH1	64135	broad.mit.edu	37	2	163163274	163163274	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163163274C>A	uc002uce.2	-	3	936	c.714G>T	c.(712-714)TGG>TGT	p.W238C		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	238					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
CSRNP3	80034	broad.mit.edu	37	2	166536038	166536038	+	Silent	SNP	C	T	T	rs144711438		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166536038C>T	uc002udf.2	+	7	1909	c.1533C>T	c.(1531-1533)AGC>AGT	p.S511S	CSRNP3_uc002udg.2_Silent_p.S511S	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	511					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5																		---	---	---	---
SCN1A	6323	broad.mit.edu	37	2	166859173	166859173	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166859173C>A	uc010zcz.1	-	21	4078	c.4060G>T	c.(4060-4062)GGC>TGC	p.G1354C	SCN1A_uc002udo.3_Missense_Mutation_p.G1234C|SCN1A_uc010fpk.2_Missense_Mutation_p.G1206C	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1365	III.|Helical; Name=S5 of repeat III; (By similarity).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)													---	---	---	---
NOSTRIN	115677	broad.mit.edu	37	2	169707788	169707788	+	Splice_Site	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169707788G>A	uc002ueg.2	+	10	734	c.730_splice	c.e10-1	p.C244_splice	NOSTRIN_uc002uef.2_Splice_Site_p.C301_splice|NOSTRIN_uc002uei.2_Splice_Site_p.C127_splice|NOSTRIN_uc010fpu.2_Splice_Site_p.C216_splice|NOSTRIN_uc002ueh.2_Splice_Site_p.C166_splice|NOSTRIN_uc002uej.2_Splice_Site_p.C127_splice	NM_001039724	NP_001034813			nitric oxide synthase trafficker isoform 2						endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0																		---	---	---	---
TLK1	9874	broad.mit.edu	37	2	171850351	171850351	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171850351A>G	uc002ugn.2	-	21	2712	c.2240T>C	c.(2239-2241)CTA>CCA	p.L747P	TLK1_uc002ugo.2_Missense_Mutation_p.L768P|TLK1_uc002ugp.2_Missense_Mutation_p.L699P|TLK1_uc010zdn.1_Missense_Mutation_p.L651P	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	747					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1																		---	---	---	---
KIAA1715	80856	broad.mit.edu	37	2	176857040	176857040	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176857040A>G	uc002ukc.1	-	4	369	c.176T>C	c.(175-177)TTA>TCA	p.L59S	KIAA1715_uc010zer.1_Missense_Mutation_p.L59S|KIAA1715_uc010fqw.1_Missense_Mutation_p.L125S|KIAA1715_uc010zes.1_Intron|KIAA1715_uc002ukd.1_Intron|KIAA1715_uc010zet.1_RNA	NM_030650	NP_085153	Q9C0E8	LNP_HUMAN	Lunapark	59	Helical; (Potential).					integral to membrane	protein binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0793)															---	---	---	---
EVX2	344191	broad.mit.edu	37	2	176947015	176947015	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176947015C>T	uc010zeu.1	-	2	776	c.590G>A	c.(589-591)CGC>CAC	p.R197H		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	197	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)														---	---	---	---
HOXD12	3238	broad.mit.edu	37	2	176964686	176964686	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176964686G>A	uc010zev.1	+	1	157	c.157G>A	c.(157-159)GCC>ACC	p.A53T	HOXD12_uc010zew.1_Missense_Mutation_p.A53T	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	53						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)														---	---	---	---
RBM45	129831	broad.mit.edu	37	2	178982857	178982857	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178982857C>T	uc002ulv.2	+	3	591	c.499C>T	c.(499-501)CGA>TGA	p.R167*		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	167	RRM 2.				cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179408762	179408762	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179408762A>G	uc010zfg.1	-	295	88629	c.88405T>C	c.(88405-88407)TCT>CCT	p.S29469P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S23164P|TTN_uc010zfi.1_Missense_Mutation_p.S23097P|TTN_uc010zfj.1_Missense_Mutation_p.S22972P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30396							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179414547	179414547	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179414547C>A	uc010zfg.1	-	287	84422	c.84198G>T	c.(84196-84198)GGG>GGT	p.G28066G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.G21761G|TTN_uc010zfi.1_Silent_p.G21694G|TTN_uc010zfj.1_Silent_p.G21569G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28993							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179422678	179422678	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179422678G>A	uc010zfg.1	-	277	79923	c.79699C>T	c.(79699-79701)CTA>TTA	p.L26567L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L20262L|TTN_uc010zfi.1_Silent_p.L20195L|TTN_uc010zfj.1_Silent_p.L20070L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27494							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179449206	179449206	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179449206A>G	uc010zfg.1	-	260	57592	c.57368T>C	c.(57367-57369)ATT>ACT	p.I19123T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I12818T|TTN_uc010zfi.1_Missense_Mutation_p.I12751T|TTN_uc010zfj.1_Missense_Mutation_p.I12626T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20050							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179463686	179463686	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179463686T>C	uc010zfg.1	-	240	49271	c.49047A>G	c.(49045-49047)ACA>ACG	p.T16349T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T10044T|TTN_uc010zfi.1_Silent_p.T9977T|TTN_uc010zfj.1_Silent_p.T9852T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17276							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179579734	179579734	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179579734C>G	uc010zfg.1	-	87	22671	c.22447G>C	c.(22447-22449)GTT>CTT	p.V7483L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V4144L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8410							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179632855	179632855	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179632855A>T	uc010zfg.1	-	39	9415	c.9191T>A	c.(9190-9192)ATT>AAT	p.I3064N	TTN_uc010zfh.1_Missense_Mutation_p.I3018N|TTN_uc010zfi.1_Missense_Mutation_p.I3018N|TTN_uc010zfj.1_Missense_Mutation_p.I3018N|TTN_uc002unb.2_Missense_Mutation_p.I3064N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3064							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179641015	179641015	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179641015C>A	uc010zfg.1	-	28	5800	c.5576G>T	c.(5575-5577)AGG>ATG	p.R1859M	TTN_uc010zfh.1_Missense_Mutation_p.R1813M|TTN_uc010zfi.1_Missense_Mutation_p.R1813M|TTN_uc010zfj.1_Missense_Mutation_p.R1813M|TTN_uc002unb.2_Missense_Mutation_p.R1859M|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1859							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
PDE1A	5136	broad.mit.edu	37	2	183387016	183387016	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183387016G>A	uc002uos.2	-	2	172	c.88C>T	c.(88-90)CGC>TGC	p.R30C	PDE1A_uc010zfp.1_5'UTR|PDE1A_uc002uoq.1_Missense_Mutation_p.R30C|PDE1A_uc010zfq.1_Missense_Mutation_p.R30C|PDE1A_uc002uov.1_RNA	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	30	Calmodulin-binding (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)															---	---	---	---
ZNF804A	91752	broad.mit.edu	37	2	185802311	185802311	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:185802311T>A	uc002uph.2	+	4	2782	c.2188T>A	c.(2188-2190)TCA>ACA	p.S730T		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	730						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11																		---	---	---	---
CALCRL	10203	broad.mit.edu	37	2	188225351	188225351	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:188225351A>G	uc002upv.3	-	10	1303	c.755T>C	c.(754-756)TTA>TCA	p.L252S	CALCRL_uc010frt.2_Missense_Mutation_p.L252S	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	252	Cytoplasmic (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)															---	---	---	---
ANKAR	150709	broad.mit.edu	37	2	190554311	190554311	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190554311T>C	uc002uqw.1	+	2	447	c.447T>C	c.(445-447)AAT>AAC	p.N149N	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqv.1_Silent_p.N220N	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	220						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)															---	---	---	---
PMS1	5378	broad.mit.edu	37	2	190732552	190732552	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190732552C>T	uc002urh.3	+	11	2899	c.2370C>T	c.(2368-2370)GAC>GAT	p.D790D	PMS1_uc002urk.3_Silent_p.D751D|PMS1_uc002uri.3_Silent_p.D628D|PMS1_uc010zgc.1_Silent_p.D614D|PMS1_uc010zgd.1_Silent_p.D614D|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Intron|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Silent_p.D413D|PMS1_uc002urm.2_RNA	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	790					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)					Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					---	---	---	---
MYO1B	4430	broad.mit.edu	37	2	192265122	192265122	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:192265122G>A	uc010fsg.2	+	22	2565	c.2310G>A	c.(2308-2310)CTG>CTA	p.L770L	MYO1B_uc002usq.2_Silent_p.L770L|MYO1B_uc002usr.2_Silent_p.L770L|MYO1B_uc002usu.2_Silent_p.L44L|MYO1B_uc002usv.2_5'Flank	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	770	IQ 3.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)															---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196664111	196664111	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196664111A>G	uc002utj.3	-	55	10363	c.10262T>C	c.(10261-10263)TTT>TCT	p.F3421S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3421	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
HECW2	57520	broad.mit.edu	37	2	197172692	197172692	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197172692T>G	uc002utm.1	-	11	2735	c.2552A>C	c.(2551-2553)AAC>ACC	p.N851T	HECW2_uc002utl.1_Missense_Mutation_p.N495T	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	851	Interaction with TP73.|Potential.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18																		---	---	---	---
GTF3C3	9330	broad.mit.edu	37	2	197664327	197664327	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197664327C>T	uc002uts.2	-	1	99	c.9G>A	c.(7-9)GGG>GGA	p.G3G	GTF3C3_uc010zgu.1_Silent_p.G3G|GTF3C3_uc002utu.2_Silent_p.G3G	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	3						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7																		---	---	---	---
C2orf69	205327	broad.mit.edu	37	2	200789806	200789806	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:200789806C>T	uc010zhb.1	+	2	538	c.355C>T	c.(355-357)CGT>TGT	p.R119C		NM_153689	NP_710156	Q8N8R5	CB069_HUMAN	hypothetical protein LOC205327 precursor	119						extracellular region				central_nervous_system(1)	1																		---	---	---	---
TRAK2	66008	broad.mit.edu	37	2	202257733	202257733	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202257733C>A	uc002uyb.3	-	10	1458	c.1012G>T	c.(1012-1014)GGA>TGA	p.G338*		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	338	Potential.			Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0																		---	---	---	---
BMPR2	659	broad.mit.edu	37	2	203329559	203329559	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:203329559C>T	uc002uzf.3	+	2	1252	c.104C>T	c.(103-105)GCG>GTG	p.A35V	BMPR2_uc010ftr.2_Missense_Mutation_p.A35V|BMPR2_uc002uze.2_Missense_Mutation_p.A35V	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	35	Extracellular (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9																		---	---	---	---
PARD3B	117583	broad.mit.edu	37	2	205989106	205989106	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:205989106C>T	uc002var.1	+	9	1428	c.1221C>T	c.(1219-1221)CCC>CCT	p.P407P	PARD3B_uc010fub.1_Silent_p.P407P|PARD3B_uc002vao.1_Silent_p.P407P|PARD3B_uc002vap.1_Silent_p.P407P|PARD3B_uc002vaq.1_Silent_p.P407P	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	407	PDZ 2.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)														---	---	---	---
NDUFS1	4719	broad.mit.edu	37	2	207008772	207008772	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207008772C>A	uc002vbe.2	-	10	1084	c.957G>T	c.(955-957)TGG>TGT	p.W319C	NDUFS1_uc010ziq.1_Missense_Mutation_p.W333C|NDUFS1_uc010zir.1_Missense_Mutation_p.W283C|NDUFS1_uc010zis.1_Missense_Mutation_p.W262C|NDUFS1_uc010zit.1_Missense_Mutation_p.W208C|NDUFS1_uc010ziu.1_Missense_Mutation_p.W203C	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	319					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)													---	---	---	---
LANCL1	10314	broad.mit.edu	37	2	211305366	211305366	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:211305366C>T	uc010zjh.1	-	6	721	c.646G>A	c.(646-648)GGG>AGG	p.G216R	LANCL1_uc002ved.2_Missense_Mutation_p.G216R|LANCL1_uc010fuq.2_Missense_Mutation_p.G216R	NM_001136574	NP_001130046	O43813	LANC1_HUMAN	lanthionine synthetase C-like protein 1	216						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding				0				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)														---	---	---	---
SPAG16	79582	broad.mit.edu	37	2	214204980	214204980	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:214204980T>C	uc002veq.2	+	6	722	c.630T>C	c.(628-630)ATT>ATC	p.I210I	SPAG16_uc010fuz.1_Silent_p.I61I|SPAG16_uc002ver.2_Silent_p.I156I|SPAG16_uc010zjk.1_Silent_p.I116I|SPAG16_uc002vep.1_Intron|SPAG16_uc002ves.1_Silent_p.I179I	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	210	Potential.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)														---	---	---	---
FN1	2335	broad.mit.edu	37	2	216257827	216257827	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216257827C>T	uc002vfa.2	-	25	4162	c.3896G>A	c.(3895-3897)CGC>CAC	p.R1299H	FN1_uc002vfb.2_Intron|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Missense_Mutation_p.R1299H|FN1_uc002vfe.2_Intron|FN1_uc002vff.2_Intron|FN1_uc002vfg.2_Intron|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Missense_Mutation_p.R1299H|FN1_uc002vfj.2_Missense_Mutation_p.R1299H|FN1_uc002vez.2_5'Flank|FN1_uc010zjp.1_5'UTR	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1299	Fibronectin type-III 8.|Cell-attachment.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
IGFBP2	3485	broad.mit.edu	37	2	217528681	217528681	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:217528681G>A	uc010zjt.1	+	6	961	c.811G>A	c.(811-813)GGG>AGG	p.G271R	IGFBP2_uc010zju.1_3'UTR	NM_000597	NP_000588	P18065	IBP2_HUMAN	insulin-like growth factor binding protein 2,	278	Thyroglobulin type-1.				positive regulation of activated T cell proliferation|regulation of cell growth|regulation of insulin-like growth factor receptor signaling pathway	extracellular space	insulin-like growth factor I binding|insulin-like growth factor II binding				0		Renal(323;0.0458)		Epithelial(149;2.9e-06)|all cancers(144;0.000223)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00968)														---	---	---	---
RUFY4	285180	broad.mit.edu	37	2	218940176	218940176	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:218940176C>T	uc002vgw.2	+	10	2286	c.442C>T	c.(442-444)CTG>TTG	p.L148L	RUFY4_uc002vgy.1_RNA|RUFY4_uc010fvl.1_Silent_p.L148L	NM_198483	NP_940885	Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	321							metal ion binding			pancreas(1)	1		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)														---	---	---	---
CTDSP1	58190	broad.mit.edu	37	2	219268006	219268006	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219268006C>T	uc002vhy.2	+	6	859	c.523C>T	c.(523-525)CGG>TGG	p.R175W	CTDSP1_uc002vhx.2_Missense_Mutation_p.R174W|CTDSP1_uc002vhz.2_Missense_Mutation_p.R34W	NM_021198	NP_067021	Q9GZU7	CTDS1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	175	FCP1 homology.				protein dephosphorylation|regulation of transcription from RNA polymerase II promoter	nucleus	CTD phosphatase activity|metal ion binding|protein binding			ovary(1)	1		Renal(207;0.0915)		Epithelial(149;9.96e-07)|all cancers(144;0.00017)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
ZNF142	7701	broad.mit.edu	37	2	219508772	219508772	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219508772G>A	uc002vin.2	-	8	2903	c.2467C>T	c.(2467-2469)CGG>TGG	p.R823W	ZNF142_uc002vil.2_Missense_Mutation_p.R784W|ZNF142_uc010fvt.2_Missense_Mutation_p.R660W|ZNF142_uc002vim.2_Missense_Mutation_p.R660W	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	823					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)														---	---	---	---
RNF25	64320	broad.mit.edu	37	2	219529239	219529239	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219529239G>T	uc002vit.2	-	10	909	c.821C>A	c.(820-822)CCT>CAT	p.P274H	RNF25_uc010fvw.2_Missense_Mutation_p.P162H	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	274					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
SPEG	10290	broad.mit.edu	37	2	220348728	220348728	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220348728C>T	uc010fwg.2	+	30	6543	c.6543C>T	c.(6541-6543)CCC>CCT	p.P2181P		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2181	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)														---	---	---	---
PAX3	5077	broad.mit.edu	37	2	223158932	223158932	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223158932G>A	uc010fwo.2	-	4	906	c.540C>T	c.(538-540)AGC>AGT	p.S180S	PAX3_uc002vmt.1_Silent_p.S180S|PAX3_uc002vmy.1_Silent_p.S179S|PAX3_uc002vmv.1_Silent_p.S180S|PAX3_uc002vmw.1_Silent_p.S180S|PAX3_uc002vmx.1_Silent_p.S180S|PAX3_uc002vmz.1_Silent_p.S180S|PAX3_uc002vna.1_Silent_p.S180S	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	180					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)				T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230638845	230638845	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230638845C>T	uc002vpw.1	-	37	5546	c.5437G>A	c.(5437-5439)GTC>ATC	p.V1813I	TRIP12_uc002vpx.1_Missense_Mutation_p.V1861I|TRIP12_uc002vpy.1_Missense_Mutation_p.V1543I	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1813					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
ECEL1	9427	broad.mit.edu	37	2	233350722	233350722	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233350722G>A	uc002vsv.2	-	2	847	c.642C>T	c.(640-642)GGC>GGT	p.G214G	ECEL1_uc010fya.1_Silent_p.G214G|ECEL1_uc010fyb.1_5'UTR	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	214	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)														---	---	---	---
AGAP1	116987	broad.mit.edu	37	2	236957834	236957834	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:236957834A>G	uc002vvs.2	+	16	2618	c.2023A>G	c.(2023-2025)AAG>GAG	p.K675E	AGAP1_uc002vvt.2_Missense_Mutation_p.K622E	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	675	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
UBE2F	140739	broad.mit.edu	37	2	238944574	238944574	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238944574G>A	uc002vxk.2	+	9	591	c.500G>A	c.(499-501)CGG>CAG	p.R167Q	UBE2F_uc010znn.1_Missense_Mutation_p.R135Q|UBE2F_uc002vxl.2_RNA|UBE2F_uc010zno.1_RNA|UBE2F_uc010znp.1_3'UTR|SCLY_uc002vxm.3_5'UTR	NM_080678	NP_542409	Q969M7	UBE2F_HUMAN	NEDD8-conjugating enzyme	167					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding				0		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;6.7e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|Kidney(56;3.53e-09)|KIRC - Kidney renal clear cell carcinoma(57;9.79e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000136)|Lung(119;0.0126)|LUSC - Lung squamous cell carcinoma(224;0.0301)														---	---	---	---
GPC1	2817	broad.mit.edu	37	2	241401875	241401875	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241401875C>T	uc002vyw.3	+	3	814	c.593C>T	c.(592-594)GCG>GTG	p.A198V		NM_002081	NP_002072	P35052	GPC1_HUMAN	glypican 1 precursor	198					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)														---	---	---	---
KIF1A	547	broad.mit.edu	37	2	241679772	241679772	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241679772C>T	uc002vzy.2	-	34	3602	c.3456G>A	c.(3454-3456)CCG>CCA	p.P1152P	KIF1A_uc010fzk.2_Silent_p.P1253P|KIF1A_uc002vzz.1_Silent_p.P1253P	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1152					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)														---	---	---	---
PPP1R7	5510	broad.mit.edu	37	2	242105795	242105795	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242105795A>G	uc002wat.1	+	8	773	c.758A>G	c.(757-759)AAC>AGC	p.N253S	PPP1R7_uc010fzm.1_Missense_Mutation_p.N237S|PPP1R7_uc002war.2_Missense_Mutation_p.N247S|PPP1R7_uc002was.2_Missense_Mutation_p.N253S|PPP1R7_uc002wau.1_Missense_Mutation_p.N210S|PPP1R7_uc002wav.1_Missense_Mutation_p.N179S	NM_002712	NP_002703	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	253	LRR 9.					cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			ovary(3)	3		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)														---	---	---	---
HDLBP	3069	broad.mit.edu	37	2	242179413	242179413	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242179413G>A	uc002waz.2	-	18	2522	c.2294C>T	c.(2293-2295)GCG>GTG	p.A765V	HDLBP_uc002wba.2_Missense_Mutation_p.A765V|HDLBP_uc002wbb.2_Missense_Mutation_p.A717V	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	765	KH 9.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)														---	---	---	---
HDLBP	3069	broad.mit.edu	37	2	242203935	242203935	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242203935C>A	uc002waz.2	-	4	390	c.162G>T	c.(160-162)CTG>CTT	p.L54L	HDLBP_uc002wba.2_Silent_p.L54L|HDLBP_uc002wbb.2_Silent_p.L75L|HDLBP_uc010fzn.1_5'UTR|uc010zoo.1_5'Flank	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	54					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)														---	---	---	---
BRPF1	7862	broad.mit.edu	37	3	9776150	9776150	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9776150G>A	uc003bse.2	+	2	725	c.326G>A	c.(325-327)CGC>CAC	p.R109H	BRPF1_uc003bsf.2_Missense_Mutation_p.R109H|BRPF1_uc003bsg.2_Missense_Mutation_p.R109H|BRPF1_uc011ati.1_Missense_Mutation_p.R109H	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	109	Interaction with MYST3 and MYST4.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)																	---	---	---	---
FANCD2	2177	broad.mit.edu	37	3	10130535	10130535	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10130535G>A	uc003buw.2	+	36	3662	c.3584G>A	c.(3583-3585)AGC>AAC	p.S1195N	FANCD2_uc003bux.1_Missense_Mutation_p.S1195N|FANCD2_uc003buy.1_Missense_Mutation_p.S1195N|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1195					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)				D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
CAPN7	23473	broad.mit.edu	37	3	15288865	15288865	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15288865G>A	uc003bzn.2	+	19	2375	c.2105G>A	c.(2104-2106)GGA>GAA	p.G702E		NM_014296	NP_055111	Q9Y6W3	CAN7_HUMAN	calpain 7	702	Domain N.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
GALNTL2	117248	broad.mit.edu	37	3	16217107	16217107	+	Missense_Mutation	SNP	C	T	T	rs145670083	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:16217107C>T	uc003car.3	+	1	924	c.449C>T	c.(448-450)ACC>ATC	p.T150I	GALNTL2_uc003caq.3_Intron	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	150	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1																		---	---	---	---
TBC1D5	9779	broad.mit.edu	37	3	17202725	17202725	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:17202725G>A	uc003cbf.2	-	22	3783	c.2118C>T	c.(2116-2118)TGC>TGT	p.C706C	TBC1D5_uc010heu.2_Silent_p.C293C|TBC1D5_uc010hev.2_Silent_p.C728C|TBC1D5_uc003cbe.2_Silent_p.C706C	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	706						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
SATB1	6304	broad.mit.edu	37	3	18457551	18457551	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:18457551C>G	uc003cbh.2	-	4	2198	c.463G>C	c.(463-465)GAT>CAT	p.D155H	SATB1_uc003cbi.2_Missense_Mutation_p.D155H|SATB1_uc003cbj.2_Missense_Mutation_p.D155H	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	155	PDZ-like dimerization domain.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4																		---	---	---	---
SGOL1	151648	broad.mit.edu	37	3	20202590	20202590	+	3'UTR	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:20202590G>A	uc003cbs.2	-	9					SGOL1_uc003cbr.2_3'UTR|SGOL1_uc010hfa.2_3'UTR|SGOL1_uc003cbt.2_3'UTR|SGOL1_uc003cbu.2_3'UTR|SGOL1_uc003cbv.2_3'UTR|SGOL1_uc003cbw.2_3'UTR	NM_001012410	NP_001012410			shugoshin-like 1 isoform A2						attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0																		---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33576740	33576740	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33576740C>T	uc003cfu.2	-	33	4126	c.3772G>A	c.(3772-3774)GAC>AAC	p.D1258N	CLASP2_uc003cfs.2_Missense_Mutation_p.D465N|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.D858N	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1267										ovary(3)|central_nervous_system(1)	4																		---	---	---	---
LRRFIP2	9209	broad.mit.edu	37	3	37114363	37114363	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37114363C>T	uc003cgp.2	-	22	1805	c.1382G>A	c.(1381-1383)CGC>CAC	p.R461H	LRRFIP2_uc011ayf.1_Missense_Mutation_p.R277H|LRRFIP2_uc003cgr.2_Intron|LRRFIP2_uc003cgs.3_Intron|LRRFIP2_uc003cgt.3_Intron	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	461	Potential.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1																		---	---	---	---
ACVR2B	93	broad.mit.edu	37	3	38524697	38524697	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38524697G>A	uc003cif.2	+	11	1437	c.1413G>A	c.(1411-1413)GCG>GCA	p.A471A	ACVR2B_uc003cig.2_Silent_p.A262A	NM_001106	NP_001097	Q13705	AVR2B_HUMAN	activin A receptor, type IIB precursor	471	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|anterior/posterior pattern formation|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|regulation of transcription, DNA-dependent	cell surface|cytoplasm|integral to plasma membrane	activin receptor activity|ATP binding|growth factor binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			lung(1)	1	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0565)|Kidney(284;0.071)														---	---	---	---
KBTBD5	131377	broad.mit.edu	37	3	42728053	42728053	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42728053T>C	uc003clv.1	+	1	1043	c.943T>C	c.(943-945)TTC>CTC	p.F315L		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	315										ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)														---	---	---	---
CCR3	1232	broad.mit.edu	37	3	46307386	46307386	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46307386C>T	uc003cpg.1	+	4	1280	c.737C>T	c.(736-738)GCG>GTG	p.A246V	CCR3_uc003cpi.1_Missense_Mutation_p.A246V|CCR3_uc003cpj.1_Missense_Mutation_p.A246V|CCR3_uc003cpk.1_Missense_Mutation_p.A267V|CCR3_uc010hjb.1_Missense_Mutation_p.A264V|CCR3_uc003cpl.1_Missense_Mutation_p.A279V	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	246	Helical; Name=6; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)														---	---	---	---
LTF	4057	broad.mit.edu	37	3	46490404	46490404	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46490404C>T	uc003cpq.2	-	9	1200	c.1162G>A	c.(1162-1164)GTG>ATG	p.V388M	LTF_uc003fzr.2_Missense_Mutation_p.V344M|LTF_uc010hjh.2_Missense_Mutation_p.V388M|LTF_uc003cpr.2_Missense_Mutation_p.V375M	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	388	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity	p.V388E(1)		central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)													---	---	---	---
RTP3	83597	broad.mit.edu	37	3	46539601	46539601	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46539601C>T	uc003cps.1	+	1	117	c.49C>T	c.(49-51)CGG>TGG	p.R17W		NM_031440	NP_113628	Q9BQQ7	RTP3_HUMAN	transmembrane protein 7	17	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)														---	---	---	---
MAP4	4134	broad.mit.edu	37	3	47951306	47951306	+	Intron	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47951306A>T	uc003csb.2	-						MAP4_uc003csc.3_Intron|MAP4_uc011bbf.1_Intron|MAP4_uc003cry.2_Missense_Mutation_p.D142E|MAP4_uc003csa.3_Missense_Mutation_p.D142E|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Missense_Mutation_p.D142E	NM_002375	NP_002366			microtubule-associated protein 4 isoform 1						negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)														---	---	---	---
COL7A1	1294	broad.mit.edu	37	3	48613062	48613062	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48613062C>A	uc003ctz.2	-	72	5977	c.5976G>T	c.(5974-5976)AAG>AAT	p.K1992N		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1992	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
IP6K2	51447	broad.mit.edu	37	3	48725986	48725986	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48725986A>G	uc003cup.2	-	6	1245	c.1001T>C	c.(1000-1002)ATT>ACT	p.I334T	NCKIPSD_uc003cum.2_5'Flank|NCKIPSD_uc003cun.2_5'Flank|NCKIPSD_uc010hkh.1_5'Flank|IP6K2_uc003cuq.2_Missense_Mutation_p.I334T	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	334					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0																		---	---	---	---
DAG1	1605	broad.mit.edu	37	3	49569667	49569667	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49569667T>C	uc003cxc.3	+	3	2141	c.1723T>C	c.(1723-1725)TAT>CAT	p.Y575H		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	575	Peptidase S72.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)														---	---	---	---
RBM6	10180	broad.mit.edu	37	3	50099388	50099388	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50099388A>G	uc003cyc.2	+						RBM6_uc010hlc.1_Intron|RBM6_uc003cyd.2_Intron|RBM6_uc003cye.2_Intron|RBM6_uc011bdi.1_Intron|RBM6_uc010hld.1_Intron|RBM6_uc010hle.1_Intron|RBM6_uc010hlf.1_Intron	NM_005777	NP_005768			RNA binding motif protein 6						RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)														---	---	---	---
RBM6	10180	broad.mit.edu	37	3	50103840	50103840	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50103840A>G	uc003cyc.2	+	17	2981	c.2848A>G	c.(2848-2850)ACT>GCT	p.T950A	RBM6_uc010hlc.1_3'UTR|RBM6_uc003cyd.2_Missense_Mutation_p.T428A|RBM6_uc003cye.2_Missense_Mutation_p.T428A|RBM6_uc011bdi.1_Missense_Mutation_p.T292A|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	950					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)														---	---	---	---
FAM116A	201627	broad.mit.edu	37	3	57614584	57614584	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57614584G>C	uc003dja.2	-	19	1720	c.1649C>G	c.(1648-1650)ACA>AGA	p.T550R		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	550										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)														---	---	---	---
SLMAP	7871	broad.mit.edu	37	3	57743471	57743471	+	Silent	SNP	C	T	T	rs144914455	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57743471C>T	uc003dje.1	+	1	298	c.93C>T	c.(91-93)GGC>GGT	p.G31G	SLMAP_uc003djc.1_Silent_p.G31G|SLMAP_uc003djd.1_Silent_p.G31G|SLMAP_uc003djf.1_Silent_p.G31G	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	31	Necessary for targeting to centrosomes (By similarity).|Cytoplasmic (Potential).|FHA.				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)														---	---	---	---
SLMAP	7871	broad.mit.edu	37	3	57913085	57913085	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57913085C>T	uc003dje.1	+	22	2662	c.2457C>T	c.(2455-2457)TAC>TAT	p.Y819Y	SLMAP_uc003djd.1_Silent_p.Y802Y|SLMAP_uc003djf.1_Silent_p.Y781Y|SLMAP_uc003djg.1_3'UTR|SLMAP_uc011bez.1_Silent_p.Y287Y|SLMAP_uc011bfa.1_Silent_p.Y353Y|SLMAP_uc003dji.1_3'UTR|SLMAP_uc011bfb.1_Silent_p.Y353Y|SLMAP_uc011bfc.1_3'UTR	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	819	Helical; Anchor for type IV membrane protein; (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)														---	---	---	---
MAGI1	9223	broad.mit.edu	37	3	65342204	65342204	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:65342204C>A	uc003dmn.2	-	23	4764	c.4238G>T	c.(4237-4239)CGG>CTG	p.R1413L	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1442					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)														---	---	---	---
MAGI1	9223	broad.mit.edu	37	3	65342235	65342235	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:65342235G>A	uc003dmn.2	-	23	4733	c.4207C>T	c.(4207-4209)CGC>TGC	p.R1403C	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1432					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)														---	---	---	---
MAGI1	9223	broad.mit.edu	37	3	65456114	65456114	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:65456114A>G	uc003dmn.2	-	5	1329	c.803T>C	c.(802-804)TTA>TCA	p.L268S	MAGI1_uc003dmm.2_Missense_Mutation_p.L268S|MAGI1_uc003dmo.2_Missense_Mutation_p.L268S|MAGI1_uc003dmp.2_Missense_Mutation_p.L268S|MAGI1_uc010hny.2_Missense_Mutation_p.L153S|MAGI1_uc003dmr.2_Missense_Mutation_p.L269S	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	268	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)														---	---	---	---
UBA3	9039	broad.mit.edu	37	3	69105035	69105035	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:69105035G>A	uc003dno.2	-	17	1290	c.1270C>T	c.(1270-1272)CGA>TGA	p.R424*	UBA3_uc003dnq.2_Nonsense_Mutation_p.R410*|UBA3_uc011bfy.1_Nonsense_Mutation_p.R247*|UBA3_uc011bfz.1_Nonsense_Mutation_p.R247*	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	424	Interaction with UBE2M core domain.			R->A: No effect on NEDD8 transfer to UBE2M.	protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)														---	---	---	---
FOXP1	27086	broad.mit.edu	37	3	71090486	71090486	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:71090486T>C	uc003dol.2	-	7	1185	c.862A>G	c.(862-864)AGG>GGG	p.R288G	FOXP1_uc003dom.2_Missense_Mutation_p.R212G|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.R288G|FOXP1_uc003dop.2_Missense_Mutation_p.R288G|FOXP1_uc003doq.1_Missense_Mutation_p.R287G|FOXP1_uc003doi.2_Missense_Mutation_p.R188G|FOXP1_uc003doj.2_Missense_Mutation_p.R188G|FOXP1_uc003dok.2_Missense_Mutation_p.R101G|FOXP1_uc003dor.1_Missense_Mutation_p.R66G	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	288					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)				T	PAX5	ALL								---	---	---	---
ARL13B	200894	broad.mit.edu	37	3	93755579	93755579	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:93755579C>T	uc003drc.2	+	5	956	c.670C>T	c.(670-672)CGA>TGA	p.R224*	ARL13B_uc010hop.2_Nonsense_Mutation_p.R75*|ARL13B_uc003drd.2_Nonsense_Mutation_p.R117*|ARL13B_uc003dre.2_Nonsense_Mutation_p.R209*|ARL13B_uc003drf.2_Nonsense_Mutation_p.R224*|ARL13B_uc003drg.2_Nonsense_Mutation_p.R121*	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	224	Potential.						GTP binding				0																		---	---	---	---
OR5H14	403273	broad.mit.edu	37	3	97868368	97868368	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97868368G>A	uc003dsg.1	+	1	139	c.139G>A	c.(139-141)GCT>ACT	p.A47T		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1																		---	---	---	---
IMPG2	50939	broad.mit.edu	37	3	100961758	100961758	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100961758T>C	uc003duq.1	-						IMPG2_uc011bhe.1_Intron	NM_016247	NP_057331			interphotoreceptor matrix proteoglycan 2						visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3																		---	---	---	---
CBLB	868	broad.mit.edu	37	3	105377982	105377982	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:105377982C>T	uc003dwc.2	-	19	3103	c.2781G>A	c.(2779-2781)GCG>GCA	p.A927A	CBLB_uc003dwa.2_Silent_p.A142A|CBLB_uc011bhi.1_Silent_p.A905A	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	927	Interaction with SH3KBP1.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9								Mis S		AML								---	---	---	---
PLCXD2	257068	broad.mit.edu	37	3	111564670	111564670	+	3'UTR	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111564670T>C	uc003dya.2	+	5					PLCXD2_uc003dxz.2_Missense_Mutation_p.L290P|PHLDB2_uc003dyc.2_5'UTR	NM_001134478	NP_001127950			phosphatidylinositol-specific phospholipase C, X						intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1																		---	---	---	---
ZBTB20	26137	broad.mit.edu	37	3	114070106	114070106	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:114070106C>T	uc003ebi.2	-	4	999	c.819G>A	c.(817-819)GCG>GCA	p.A273A	ZBTB20_uc003ebj.2_Silent_p.A200A|ZBTB20_uc010hqp.2_Silent_p.A200A|ZBTB20_uc003ebk.2_Silent_p.A200A|ZBTB20_uc003ebl.2_Silent_p.A200A|ZBTB20_uc003ebm.2_Silent_p.A200A|ZBTB20_uc003ebn.2_Silent_p.A200A|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)														---	---	---	---
ARHGAP31	57514	broad.mit.edu	37	3	119121138	119121138	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119121138G>A	uc003ecj.3	+	10	2071	c.1539G>A	c.(1537-1539)CCG>CCA	p.P513P		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	513					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2																		---	---	---	---
GSK3B	2932	broad.mit.edu	37	3	119634950	119634950	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119634950T>C	uc003edo.2	-	5	1532	c.549A>G	c.(547-549)AAA>AAG	p.K183K	GSK3B_uc003edn.2_Silent_p.K183K	NM_001146156	NP_001139628	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta isoform 2	183	Protein kinase.				axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			lung(2)	2				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)													---	---	---	---
EAF2	55840	broad.mit.edu	37	3	121575886	121575886	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121575886C>T	uc003een.2	+	4	466	c.367C>T	c.(367-369)CGT>TGT	p.R123C	EAF2_uc003eeo.2_5'UTR	NM_018456	NP_060926	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	123					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding				0				GBM - Glioblastoma multiforme(114;0.0972)														---	---	---	---
SLC15A2	6565	broad.mit.edu	37	3	121648151	121648151	+	Silent	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121648151A>T	uc003eep.2	+	17	1662	c.1509A>T	c.(1507-1509)GTA>GTT	p.V503V	SLC15A2_uc011bjn.1_Silent_p.V472V	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	503					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)													---	---	---	---
ILDR1	286676	broad.mit.edu	37	3	121712733	121712733	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121712733T>C	uc003ees.2	-	7	969	c.863A>G	c.(862-864)TAT>TGT	p.Y288C	ILDR1_uc003eeq.2_Missense_Mutation_p.Y256C|ILDR1_uc003eer.2_Missense_Mutation_p.Y244C|ILDR1_uc010hrg.2_Missense_Mutation_p.Y199C	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	288	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)														---	---	---	---
ADCY5	111	broad.mit.edu	37	3	123166294	123166294	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:123166294G>A	uc003egh.1	-	1	1099	c.1099C>T	c.(1099-1101)CGC>TGC	p.R367C		NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	367					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)														---	---	---	---
HEG1	57493	broad.mit.edu	37	3	124689492	124689492	+	3'UTR	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124689492G>A	uc003ehs.3	-	17					HEG1_uc003ehr.3_3'UTR|HEG1_uc011bke.1_3'UTR	NM_020733	NP_065784			HEG homolog 1 precursor							extracellular region|integral to membrane	calcium ion binding			ovary(2)	2																		---	---	---	---
ALDH1L1	10840	broad.mit.edu	37	3	125849069	125849069	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:125849069A>T	uc003eim.1	-	14	1881	c.1691T>A	c.(1690-1692)GTT>GAT	p.V564D	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.V463D|ALDH1L1_uc003eio.2_Missense_Mutation_p.V266D	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	564	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)													---	---	---	---
RUVBL1	8607	broad.mit.edu	37	3	127816251	127816251	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:127816251T>C	uc003ekh.2	-	8	1012	c.908A>G	c.(907-909)GAG>GGG	p.E303G	RUVBL1_uc003eke.2_Missense_Mutation_p.E44G|RUVBL1_uc003ekf.2_Missense_Mutation_p.E243G|RUVBL1_uc010hss.2_Missense_Mutation_p.E303G	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	303					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)														---	---	---	---
IFT122	55764	broad.mit.edu	37	3	129211008	129211008	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129211008C>T	uc003emm.2	+	17	2223	c.2017C>T	c.(2017-2019)CGA>TGA	p.R673*	IFT122_uc003eml.2_Nonsense_Mutation_p.R724*|IFT122_uc003emn.2_Nonsense_Mutation_p.R614*|IFT122_uc003emo.2_Nonsense_Mutation_p.R562*|IFT122_uc003emp.2_Nonsense_Mutation_p.R523*|IFT122_uc010htc.2_Nonsense_Mutation_p.R665*|IFT122_uc011bky.1_Nonsense_Mutation_p.R464*|IFT122_uc003emq.2_Nonsense_Mutation_p.R513*|IFT122_uc003emr.2_Intron|IFT122_uc011bla.1_Intron|IFT122_uc010hte.2_Nonsense_Mutation_p.R53*|IFT122_uc003ems.2_Intron|IFT122_uc011bkx.1_Nonsense_Mutation_p.R513*|IFT122_uc010htd.1_Nonsense_Mutation_p.R152*	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	673					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2																		---	---	---	---
ASTE1	28990	broad.mit.edu	37	3	130743090	130743090	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130743090G>A	uc003env.1	-	3	1503	c.1061C>T	c.(1060-1062)CCC>CTC	p.P354L	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Missense_Mutation_p.P354L|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	354				ILP -> FLH (in Ref. 4; AAF14876).	DNA repair		nuclease activity				0																		---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133320111	133320111	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133320111G>A	uc003eps.2	-	28	4684	c.4552C>T	c.(4552-4554)CGA>TGA	p.R1518*		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	1518	Nuclear localization signal (Potential).				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
EPHB1	2047	broad.mit.edu	37	3	134851684	134851684	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:134851684C>T	uc003eqt.2	+	5	1310	c.1090C>T	c.(1090-1092)CGG>TGG	p.R364W	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	364	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.R364L(1)		lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30																		---	---	---	---
FOXL2	668	broad.mit.edu	37	3	138664511	138664511	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:138664511C>T	uc003esw.2	-	1	1472	c.1054G>A	c.(1054-1056)GAG>AAG	p.E352K	uc003esv.1_5'Flank|C3orf72_uc003esx.1_5'Flank|C3orf72_uc011bmr.1_5'Flank	NM_023067	NP_075555	P58012	FOXL2_HUMAN	forkhead box L2	352					convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			ovary(266)|large_intestine(1)|skin(1)	268								Mis		granulosa-cell tumour of the ovary		Blepharophimosis|ptosis and epicanthus inversus Types I|II; Premature ovarian failure type III						---	---	---	---
PAQR9	344838	broad.mit.edu	37	3	142681359	142681359	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142681359A>C	uc003evg.2	-	1	820	c.820T>G	c.(820-822)TTC>GTC	p.F274V	PAQR9_uc003evf.1_RNA	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	274	Extracellular (Potential).					integral to membrane	receptor activity				0																		---	---	---	---
SR140	23350	broad.mit.edu	37	3	142741881	142741881	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142741881C>A	uc003evh.1	+	12	1304	c.1205C>A	c.(1204-1206)CCT>CAT	p.P402H	SR140_uc003evi.1_Missense_Mutation_p.L8I|SR140_uc011bnj.1_Missense_Mutation_p.P402H|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.P401H|SR140_uc003evl.1_5'Flank	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	402	Pro-rich.				RNA processing	nucleus	nucleotide binding|RNA binding				0																		---	---	---	---
ZIC4	84107	broad.mit.edu	37	3	147114002	147114002	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:147114002C>T	uc003ewd.1	-	3	598	c.325G>A	c.(325-327)GCG>ACG	p.A109T	ZIC4_uc003ewc.1_Missense_Mutation_p.A39T|ZIC4_uc011bno.1_Missense_Mutation_p.A159T	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	109						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2																		---	---	---	---
EIF2A	83939	broad.mit.edu	37	3	150289982	150289982	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150289982A>G	uc003eya.2	+	10	1065	c.1049A>G	c.(1048-1050)AAA>AGA	p.K350R	SERP1_uc003exz.2_Intron|EIF2A_uc003eyb.2_Missense_Mutation_p.K223R|EIF2A_uc003eyc.2_Missense_Mutation_p.K223R|EIF2A_uc011bnv.1_Missense_Mutation_p.K325R|EIF2A_uc011bnw.1_Missense_Mutation_p.K289R|EIF2A_uc003eyd.2_Missense_Mutation_p.K125R|uc003eye.1_Intron	NM_032025	NP_114414	Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A	350					regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
P2RY12	64805	broad.mit.edu	37	3	151056290	151056290	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151056290A>G	uc003eyw.1	-	2	560	c.344T>C	c.(343-345)CTG>CCG	p.L115P	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Missense_Mutation_p.L115P	NM_176876	NP_795345	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y12	115	Helical; Name=3; (Potential).				platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)													---	---	---	---
DHX36	170506	broad.mit.edu	37	3	154017707	154017707	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154017707G>A	uc003ezy.3	-	12	1550	c.1469C>T	c.(1468-1470)GCG>GTG	p.A490V	DHX36_uc010hvq.2_Missense_Mutation_p.A490V|DHX36_uc003ezz.3_Missense_Mutation_p.A490V	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	490	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
RSRC1	51319	broad.mit.edu	37	3	157840089	157840089	+	Splice_Site	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:157840089T>G	uc003fbt.2	+	2	305	c.194_splice	c.e2+2	p.R65_splice	RSRC1_uc011bou.1_Splice_Site_p.R65_splice|RSRC1_uc003fbu.1_Splice_Site_p.R65_splice|RSRC1_uc003fbv.2_Splice_Site_p.R65_splice	NM_016625	NP_057709			arginine/serine-rich coiled-coil 1						nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)															---	---	---	---
WDR49	151790	broad.mit.edu	37	3	167217963	167217963	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167217963C>T	uc003fev.1	-	14	2259	c.1953G>A	c.(1951-1953)CTG>CTA	p.L651L	WDR49_uc003feu.1_Silent_p.L476L|WDR49_uc011bpd.1_Silent_p.L616L|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	651										large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
PRKCI	5584	broad.mit.edu	37	3	169998141	169998141	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169998141C>T	uc003fgs.2	+	9	1070	c.832C>T	c.(832-834)CGT>TGT	p.R278C		NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	278	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)															---	---	---	---
SLC7A14	57709	broad.mit.edu	37	3	170244713	170244713	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170244713A>C	uc003fgz.2	-	2	329	c.13T>G	c.(13-15)TTC>GTC	p.F5V	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	5						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)															---	---	---	---
KCNMB2	10242	broad.mit.edu	37	3	178546005	178546005	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178546005G>A	uc003fjd.2	+	4	610	c.267G>A	c.(265-267)GCG>GCA	p.A89A	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Silent_p.A89A|KCNMB2_uc003fjf.2_Silent_p.A89A|KCNMB2_uc011bqa.1_Intron|KCNMB2_uc011bqb.1_Intron	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	89	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)															---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
USP13	8975	broad.mit.edu	37	3	179474842	179474842	+	Missense_Mutation	SNP	C	T	T	rs149947980		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179474842C>T	uc003fkh.2	+	16	2005	c.1924C>T	c.(1924-1926)CGC>TGC	p.R642C	USP13_uc003fkf.2_3'UTR	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	642					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)															---	---	---	---
ATP11B	23200	broad.mit.edu	37	3	182631638	182631638	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:182631638A>G	uc003flb.2	+						ATP11B_uc003flc.2_Intron|ATP11B_uc010hxg.2_Intron|ATP11B_uc010hxh.1_Intron	NM_014616	NP_055431			ATPase, class VI, type 11B						aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)															---	---	---	---
ABCF3	55324	broad.mit.edu	37	3	183911390	183911390	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183911390G>A	uc003fmz.2	+	21	2167	c.2034G>A	c.(2032-2034)TGG>TGA	p.W678*	ABCF3_uc003fna.2_Nonsense_Mutation_p.W672*|ABCF3_uc003fnb.2_Nonsense_Mutation_p.W359*	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	678	ABC transporter 2.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)															---	---	---	---
VPS8	23355	broad.mit.edu	37	3	184633161	184633161	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184633161C>T	uc003fpb.1	+	27	2446	c.2275C>T	c.(2275-2277)CGC>TGC	p.R759C	VPS8_uc010hyd.1_Missense_Mutation_p.R669C|VPS8_uc010hye.1_Missense_Mutation_p.R188C	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	761							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)															---	---	---	---
FETUB	26998	broad.mit.edu	37	3	186360309	186360309	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:186360309T>C	uc010hyq.2	+	4	647	c.386T>C	c.(385-387)GTT>GCT	p.V129A	FETUB_uc011brz.1_Intron|FETUB_uc003fqn.2_Missense_Mutation_p.V129A|FETUB_uc003fqo.2_Missense_Mutation_p.V24A|FETUB_uc010hyr.2_Missense_Mutation_p.V92A|FETUB_uc010hys.2_Intron|FETUB_uc003fqp.3_Intron	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	129	Cystatin fetuin-B-type 1.					extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)														---	---	---	---
TP63	8626	broad.mit.edu	37	3	189526243	189526243	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:189526243C>T	uc003fry.2	+	4	596	c.507C>T	c.(505-507)ACC>ACT	p.T169T	TP63_uc003frx.2_Silent_p.T169T|TP63_uc003frz.2_Silent_p.T169T|TP63_uc010hzc.1_Silent_p.T169T|TP63_uc003fsa.2_Silent_p.T75T|TP63_uc003fsb.2_Silent_p.T75T|TP63_uc003fsc.2_Silent_p.T75T|TP63_uc003fsd.2_Silent_p.T75T|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Silent_p.T50T	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	169					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)										Hay-Wells_syndrome	HNSCC(45;0.13)			---	---	---	---
ACAP2	23527	broad.mit.edu	37	3	195022369	195022369	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195022369G>T	uc003fun.3	-	15	1571	c.1330C>A	c.(1330-1332)CTT>ATT	p.L444I		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	444	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
PPP1R2	5504	broad.mit.edu	37	3	195245831	195245831	+	Silent	SNP	C	T	T	rs144914044	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195245831C>T	uc003fup.2	-	5	931	c.555G>A	c.(553-555)ACG>ACA	p.T185T		NM_006241	NP_006232	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory subunit 2	185					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			urinary_tract(1)	1	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)														---	---	---	---
MUC4	4585	broad.mit.edu	37	3	195498524	195498524	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195498524T>C	uc011bto.1	-	6	13317	c.12857A>G	c.(12856-12858)CAG>CGG	p.Q4286R	MUC4_uc003fuz.2_Missense_Mutation_p.R94G|MUC4_uc003fva.2_5'UTR|MUC4_uc003fvb.2_5'UTR|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_5'UTR|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_5'UTR|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_5'UTR|MUC4_uc011bti.1_5'UTR|MUC4_uc011btj.1_Missense_Mutation_p.Q155R|MUC4_uc011btk.1_5'UTR|MUC4_uc011btl.1_5'UTR|MUC4_uc011btm.1_Missense_Mutation_p.Q155R|MUC4_uc011btn.1_5'UTR|MUC4_uc003fvo.2_Missense_Mutation_p.Q178R|MUC4_uc003fvp.2_Missense_Mutation_p.Q127R|MUC4_uc010hzu.1_Missense_Mutation_p.Q1026R	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1171	NIDO.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)														---	---	---	---
MUC4	4585	broad.mit.edu	37	3	195515664	195515664	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195515664G>A	uc011bto.1	-	2	3247	c.2787C>T	c.(2785-2787)ACC>ACT	p.T929T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Silent_p.T811T	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	934	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)														---	---	---	---
LRRC33	375387	broad.mit.edu	37	3	196386812	196386812	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196386812G>A	uc003fwv.2	+	3	402	c.298G>A	c.(298-300)GCC>ACC	p.A100T		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	100	Extracellular (Potential).|LRR 2.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)														---	---	---	---
PIGG	54872	broad.mit.edu	37	4	515569	515569	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:515569G>A	uc003gak.3	+	8	1589	c.1453G>A	c.(1453-1455)GCC>ACC	p.A485T	PIGG_uc003gaj.3_Missense_Mutation_p.A477T|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.A352T|PIGG_uc003gal.3_Missense_Mutation_p.A396T|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_3'UTR|PIGG_uc003gam.2_3'UTR|PIGG_uc003gan.2_Missense_Mutation_p.A396T	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	485	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4																		---	---	---	---
MFSD10	10227	broad.mit.edu	37	4	2933196	2933196	+	Intron	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2933196C>A	uc003gfw.2	-						MFSD10_uc003gfv.2_Intron|MFSD10_uc003gfx.2_Intron|MFSD10_uc003gfz.2_Intron|MFSD10_uc003gfy.2_Intron|MFSD10_uc003gga.2_Intron|MFSD10_uc003ggb.1_Intron|MFSD10_uc003ggc.2_Intron	NM_001120	NP_001111			major facilitator superfamily domain containing						apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)														---	---	---	---
NOP14	8602	broad.mit.edu	37	4	2944054	2944054	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2944054C>A	uc003ggj.1	-	14	1988	c.1916G>T	c.(1915-1917)AGA>ATA	p.R639I	C4orf10_uc003gge.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.R385I|NOP14_uc003ggk.3_Missense_Mutation_p.R639I|NOP14_uc003ggl.2_Missense_Mutation_p.R639I	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	639					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1																		---	---	---	---
NOP14	8602	broad.mit.edu	37	4	2948203	2948203	+	Missense_Mutation	SNP	G	A	A	rs114205498	byFrequency;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2948203G>A	uc003ggj.1	-	11	1643	c.1571C>T	c.(1570-1572)GCG>GTG	p.A524V	C4orf10_uc003gge.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.A270V|NOP14_uc003ggk.3_Missense_Mutation_p.A524V|NOP14_uc003ggl.2_Missense_Mutation_p.A524V	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	524					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1																		---	---	---	---
OTOP1	133060	broad.mit.edu	37	4	4190572	4190572	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:4190572C>G	uc003ghp.1	-	6	1827	c.1797G>C	c.(1795-1797)ATG>ATC	p.M599I		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	599					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
STK32B	55351	broad.mit.edu	37	4	5461854	5461854	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5461854C>T	uc003gih.1	+	9	872	c.808C>T	c.(808-810)CGC>TGC	p.R270C	STK32B_uc010ida.1_Missense_Mutation_p.R223C	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	270	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5																OREG0016061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
JAKMIP1	152789	broad.mit.edu	37	4	6107525	6107525	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6107525G>A	uc003giu.3	-	3	575	c.299C>T	c.(298-300)GCG>GTG	p.A100V	JAKMIP1_uc010idb.1_Missense_Mutation_p.A100V|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.A100V|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.A100V|JAKMIP1_uc010ide.2_Missense_Mutation_p.A100V	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	100	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4																		---	---	---	---
KIAA0232	9778	broad.mit.edu	37	4	6863563	6863563	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6863563G>T	uc003gjr.3	+	7	1917	c.1454G>T	c.(1453-1455)GGG>GTG	p.G485V	KIAA0232_uc003gjq.3_Missense_Mutation_p.G485V	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	485							ATP binding			ovary(2)	2																		---	---	---	---
SH3TC1	54436	broad.mit.edu	37	4	8229894	8229894	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8229894G>A	uc003gkv.3	+	12	2574	c.2473G>A	c.(2473-2475)GTG>ATG	p.V825M	SH3TC1_uc003gkw.3_Missense_Mutation_p.V749M|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	825							binding			large_intestine(2)|pancreas(1)	3																		---	---	---	---
GPR78	27201	broad.mit.edu	37	4	8582915	8582915	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8582915G>A	uc003glk.2	+	1	625	c.206G>A	c.(205-207)CGC>CAC	p.R69H	CPZ_uc003gll.2_RNA	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	69	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6																		---	---	---	---
DRD5	1816	broad.mit.edu	37	4	9784426	9784426	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:9784426G>T	uc003gmb.3	+	1	1169	c.773G>T	c.(772-774)AGG>ATG	p.R258M		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	258	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)													---	---	---	---
SLC2A9	56606	broad.mit.edu	37	4	9922008	9922008	+	Splice_Site	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:9922008C>G	uc003gmc.2	-	7	1063	c.1002_splice	c.e7+1	p.A334_splice	SLC2A9_uc003gmd.2_Splice_Site_p.A305_splice	NM_020041	NP_064425			solute carrier family 2, member 9 protein						glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3																		---	---	---	---
CPEB2	132864	broad.mit.edu	37	4	15054158	15054158	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15054158G>A	uc003gni.1	+	6	1073	c.986G>A	c.(985-987)CGC>CAC	p.R329H	CPEB2_uc003gnj.1_Missense_Mutation_p.R299H|CPEB2_uc003gnk.1_Missense_Mutation_p.R337H|CPEB2_uc003gnl.1_Missense_Mutation_p.R310H|CPEB2_uc003gnm.1_Missense_Mutation_p.R307H|CPEB2_uc003gnn.1_Missense_Mutation_p.R302H	NM_182485	NP_872291	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding	329					regulation of translation	cytoplasm	nucleotide binding|RNA binding			skin(1)	1																		---	---	---	---
C1QTNF7	114905	broad.mit.edu	37	4	15444376	15444376	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15444376G>A	uc011bxb.1	+	3	1050	c.823G>A	c.(823-825)GTT>ATT	p.V275I	C1QTNF7_uc003gno.2_Missense_Mutation_p.V282I|C1QTNF7_uc003gnp.2_Missense_Mutation_p.V275I	NM_001135171	NP_001128643	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	275	C1q.					collagen					0																		---	---	---	---
CC2D2A	57545	broad.mit.edu	37	4	15529170	15529170	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15529170A>G	uc010idv.2	+	13	1495	c.1250A>G	c.(1249-1251)CAT>CGT	p.H417R	CC2D2A_uc003gnx.2_Missense_Mutation_p.H368R|CC2D2A_uc003gnv.2_Missense_Mutation_p.H417R	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	417					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3																		---	---	---	---
CD38	952	broad.mit.edu	37	4	15780178	15780178	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15780178C>T	uc011bxc.1	+	1	248	c.141C>T	c.(139-141)CGC>CGT	p.R47R	CD38_uc003goj.1_Silent_p.R47R|CD38_uc003gol.1_Silent_p.R47R	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	47	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2																		---	---	---	---
CD38	952	broad.mit.edu	37	4	15826541	15826541	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15826541A>G	uc011bxc.1	+	3	508	c.401A>G	c.(400-402)CAG>CGG	p.Q134R	CD38_uc003goj.1_Missense_Mutation_p.Q134R|CD38_uc003gol.1_Missense_Mutation_p.Q134R	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	134	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2																		---	---	---	---
SLIT2	9353	broad.mit.edu	37	4	20487859	20487859	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20487859G>A	uc003gpr.1	+	7	780	c.576G>A	c.(574-576)GTG>GTA	p.V192V	SLIT2_uc003gps.1_Silent_p.V192V	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	192	LRR 6.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11																		---	---	---	---
DHX15	1665	broad.mit.edu	37	4	24541861	24541861	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:24541861A>G	uc003gqx.2	-	10	1824	c.1656T>C	c.(1654-1656)GAT>GAC	p.D552D	DHX15_uc003gqw.2_5'Flank	NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	552					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)																---	---	---	---
DHX15	1665	broad.mit.edu	37	4	24556348	24556348	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:24556348C>A	uc003gqx.2	-	5	1248	c.1080G>T	c.(1078-1080)GAG>GAT	p.E360D		NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	360	Helicase C-terminal.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)																---	---	---	---
SEL1L3	23231	broad.mit.edu	37	4	25823650	25823650	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25823650A>G	uc003gru.3	-	7	1410	c.1258T>C	c.(1258-1260)TAC>CAC	p.Y420H		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	420						integral to membrane	binding				0																		---	---	---	---
TBC1D19	55296	broad.mit.edu	37	4	26675418	26675418	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:26675418G>A	uc003gsf.3	+	11	994	c.724G>A	c.(724-726)GCT>ACT	p.A242T	TBC1D19_uc010iew.2_Missense_Mutation_p.A242T|TBC1D19_uc011bxu.1_Missense_Mutation_p.A177T	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	242						intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)																---	---	---	---
ARAP2	116984	broad.mit.edu	37	4	36081901	36081901	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:36081901C>T	uc003gsq.1	-	31	4883	c.4545G>A	c.(4543-4545)TGG>TGA	p.W1515*		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1515	PH 5.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
KLB	152831	broad.mit.edu	37	4	39409119	39409119	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39409119C>T	uc003gua.2	+	1	647	c.550C>T	c.(550-552)CTT>TTT	p.L184F	KLB_uc011byj.1_Missense_Mutation_p.L184F	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	184	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1																		---	---	---	---
N4BP2	55728	broad.mit.edu	37	4	40122019	40122019	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:40122019C>T	uc003guy.3	+	9	2626	c.2288C>T	c.(2287-2289)ACG>ATG	p.T763M	N4BP2_uc010ifq.2_Missense_Mutation_p.T683M|N4BP2_uc010ifr.2_Missense_Mutation_p.T683M	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	763						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8																		---	---	---	---
LIMCH1	22998	broad.mit.edu	37	4	41678464	41678464	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:41678464G>A	uc003gvu.3	+	18	2406	c.2352G>A	c.(2350-2352)CAG>CAA	p.Q784Q	LIMCH1_uc003gvv.3_Silent_p.Q784Q|LIMCH1_uc003gvw.3_Silent_p.Q783Q|LIMCH1_uc003gvx.3_Silent_p.Q796Q|LIMCH1_uc003gwe.3_Intron|LIMCH1_uc003gvy.3_Silent_p.Q612Q|LIMCH1_uc003gwa.3_Silent_p.Q624Q|LIMCH1_uc003gvz.3_Silent_p.Q1168Q|LIMCH1_uc011byu.1_Silent_p.Q617Q|LIMCH1_uc003gwc.3_Silent_p.Q629Q|LIMCH1_uc003gwd.3_Silent_p.Q617Q|LIMCH1_uc011byv.1_Silent_p.Q534Q|LIMCH1_uc011byw.1_Silent_p.Q83Q	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	784	Glu-rich.				actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
PDGFRA	5156	broad.mit.edu	37	4	55133804	55133804	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:55133804G>A	uc003han.3	+	7	1348	c.1017G>A	c.(1015-1017)GTG>GTA	p.V339V	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Silent_p.V233V|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	339	Ig-like C2-type 4.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			---	---	---	---
KIAA1211	57482	broad.mit.edu	37	4	57179385	57179385	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57179385G>A	uc003hbk.2	+	7	768	c.377G>A	c.(376-378)CGG>CAG	p.R126Q	KIAA1211_uc010iha.2_Missense_Mutation_p.R119Q|KIAA1211_uc011bzz.1_Missense_Mutation_p.R36Q|KIAA1211_uc003hbm.1_Missense_Mutation_p.R12Q	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	126										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
LPHN3	23284	broad.mit.edu	37	4	62453059	62453059	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:62453059A>C	uc010ihh.2	+	2	343	c.170A>C	c.(169-171)AAC>ACC	p.N57T	LPHN3_uc003hcq.3_Missense_Mutation_p.N57T|LPHN3_uc010ihg.1_Missense_Mutation_p.N125T	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	57	SUEL-type lectin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18																		---	---	---	---
EPHA5	2044	broad.mit.edu	37	4	66233108	66233108	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:66233108C>A	uc003hcy.2	-	10	2084	c.1891G>T	c.(1891-1893)GAA>TAA	p.E631*	EPHA5_uc003hcx.2_Nonsense_Mutation_p.E563*|EPHA5_uc003hcz.2_Nonsense_Mutation_p.E609*|EPHA5_uc011cah.1_Nonsense_Mutation_p.E632*|EPHA5_uc011cai.1_Nonsense_Mutation_p.E610*|EPHA5_uc003hda.2_Nonsense_Mutation_p.E632*	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	631	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24															TSP Lung(17;0.13)			---	---	---	---
EPHA5	2044	broad.mit.edu	37	4	66356087	66356087	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:66356087G>A	uc003hcy.2	-						EPHA5_uc003hcx.2_Intron|EPHA5_uc003hcz.2_Intron|EPHA5_uc011cah.1_Intron|EPHA5_uc011cai.1_Intron|EPHA5_uc003hda.2_Intron	NM_004439	NP_004430			ephrin receptor EphA5 isoform a precursor						cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24															TSP Lung(17;0.13)			---	---	---	---
YTHDC1	91746	broad.mit.edu	37	4	69182138	69182138	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69182138G>A	uc003hdx.2	-	16	2206	c.1853C>T	c.(1852-1854)CCA>CTA	p.P618L	YTHDC1_uc003hdy.2_Missense_Mutation_p.P600L	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	618	Pro-rich.									upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
NUP54	53371	broad.mit.edu	37	4	77053839	77053839	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77053839C>T	uc003hjs.2	-	6	872	c.744G>A	c.(742-744)TCG>TCA	p.S248S	NUP54_uc010ije.2_5'UTR|NUP54_uc011cbs.1_Silent_p.S68S|NUP54_uc011cbt.1_Silent_p.S200S|NUP54_uc003hjt.2_Silent_p.S68S	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	248	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2																		---	---	---	---
FRAS1	80144	broad.mit.edu	37	4	79400860	79400860	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:79400860A>C	uc003hlb.2	+	56	8871	c.8431A>C	c.(8431-8433)AGT>CGT	p.S2811R		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2806	Calx-beta 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5																		---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83748700	83748700	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83748700T>C	uc003hnf.2	-	24	3277	c.3113A>G	c.(3112-3114)CAA>CGA	p.Q1038R	SEC31A_uc003hnd.2_Missense_Mutation_p.Q207R|SEC31A_uc003hne.2_Missense_Mutation_p.Q787R|SEC31A_uc011ccl.1_Missense_Mutation_p.Q984R|SEC31A_uc003hnl.2_Missense_Mutation_p.Q885R|SEC31A_uc003hng.2_Missense_Mutation_p.Q1023R|SEC31A_uc003hnh.2_Missense_Mutation_p.Q1038R|SEC31A_uc003hni.2_Missense_Mutation_p.Q924R|SEC31A_uc003hnj.2_Missense_Mutation_p.Q999R|SEC31A_uc011ccm.1_Missense_Mutation_p.Q1018R|SEC31A_uc011ccn.1_Missense_Mutation_p.Q1023R|SEC31A_uc003hnk.2_Missense_Mutation_p.Q999R|SEC31A_uc003hnm.2_Missense_Mutation_p.Q1038R	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1038	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
NKX6-1	4825	broad.mit.edu	37	4	85414706	85414706	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85414706A>G	uc003hpa.1	-							NM_006168	NP_006159			NK6 transcription factor related, locus 1						detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus					0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85609232	85609232	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85609232T>C	uc003hpd.2	-							NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85662910	85662910	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85662910T>C	uc003hpd.2	-							NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
MEPE	56955	broad.mit.edu	37	4	88766899	88766899	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88766899T>C	uc003hqy.2	+	4	918	c.879T>C	c.(877-879)AGT>AGC	p.S293S	MEPE_uc010ikn.2_Silent_p.S180S	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	293					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)														---	---	---	---
HERC5	51191	broad.mit.edu	37	4	89380524	89380524	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89380524A>G	uc003hrt.2	+	2	445	c.292A>G	c.(292-294)AAG>GAG	p.K98E		NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	98	RCC1 1.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)														---	---	---	---
RAP1GDS1	5910	broad.mit.edu	37	4	99363141	99363141	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:99363141A>C	uc003htx.3	+	15	1887	c.1697A>C	c.(1696-1698)GAA>GCA	p.E566A	RAP1GDS1_uc003htw.3_Missense_Mutation_p.E567A|RAP1GDS1_uc003htv.3_Missense_Mutation_p.E566A|RAP1GDS1_uc003htz.3_Missense_Mutation_p.E517A|RAP1GDS1_uc003hty.3_Missense_Mutation_p.E518A|RAP1GDS1_uc003hua.3_Missense_Mutation_p.E475A	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	566							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)				T	NUP98	T-ALL								---	---	---	---
SEC24B	10427	broad.mit.edu	37	4	110437687	110437687	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110437687C>T	uc003hzk.2	+	11	2072	c.2017C>T	c.(2017-2019)CGT>TGT	p.R673C	SEC24B_uc003hzl.2_Missense_Mutation_p.R638C|SEC24B_uc011cfp.1_Missense_Mutation_p.R703C|SEC24B_uc011cfq.1_Missense_Mutation_p.R672C|SEC24B_uc011cfr.1_Missense_Mutation_p.R637C	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	673					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)														---	---	---	---
CFI	3426	broad.mit.edu	37	4	110682737	110682737	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110682737A>G	uc003hzr.3	-	4	802	c.594T>C	c.(592-594)TTT>TTC	p.F198F	CFI_uc003hzq.2_5'UTR|CFI_uc011cft.1_Silent_p.F198F|CFI_uc003hzs.3_Silent_p.F198F	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	198	SRCR.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)														---	---	---	---
C4orf21	55345	broad.mit.edu	37	4	113539186	113539186	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113539186A>T	uc003iau.2	-	6	2223	c.2012T>A	c.(2011-2013)ATT>AAT	p.I671N	C4orf21_uc003iaw.2_Missense_Mutation_p.I671N	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114290799	114290799	+	Silent	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114290799A>T	uc003ibe.3	+	43	11548	c.11448A>T	c.(11446-11448)ACA>ACT	p.T3816T	ANK2_uc003ibd.3_Silent_p.T1722T|ANK2_uc003ibf.3_Silent_p.T1731T|ANK2_uc011cgc.1_Silent_p.T907T|ANK2_uc003ibg.3_Silent_p.T715T|ANK2_uc003ibh.3_Silent_p.T405T|ANK2_uc011cgd.1_Silent_p.T1118T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3783					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114290876	114290876	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114290876G>T	uc003ibe.3	+	43	11625	c.11525G>T	c.(11524-11526)CGG>CTG	p.R3842L	ANK2_uc003ibd.3_Missense_Mutation_p.R1748L|ANK2_uc003ibf.3_Missense_Mutation_p.R1757L|ANK2_uc011cgc.1_Missense_Mutation_p.R933L|ANK2_uc003ibg.3_Missense_Mutation_p.R741L|ANK2_uc003ibh.3_Missense_Mutation_p.R431L|ANK2_uc011cgd.1_Missense_Mutation_p.R1144L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3809					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
NDST4	64579	broad.mit.edu	37	4	115997561	115997561	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:115997561T>G	uc003ibu.2	-	2	1311	c.632A>C	c.(631-633)GAG>GCG	p.E211A	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	211	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)														---	---	---	---
SYNPO2	171024	broad.mit.edu	37	4	119951913	119951913	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119951913C>T	uc003icm.3	+	4	2179	c.1983C>T	c.(1981-1983)TAC>TAT	p.Y661Y	SYNPO2_uc010ina.2_Silent_p.Y661Y|SYNPO2_uc010inb.2_Silent_p.Y661Y|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Silent_p.Y589Y	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	661						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2																		---	---	---	---
PCDH10	57575	broad.mit.edu	37	4	134071388	134071388	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:134071388C>T	uc003iha.2	+	1	919	c.93C>T	c.(91-93)GGC>GGT	p.G31G	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.G31G	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	31	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)														---	---	---	---
FBXW7	55294	broad.mit.edu	37	4	153245514	153245514	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:153245514A>G	uc003ims.2	-	11	1826	c.1677T>C	c.(1675-1677)CTT>CTC	p.L559L	FBXW7_uc011cii.1_Silent_p.L559L|FBXW7_uc003imt.2_Silent_p.L559L|FBXW7_uc011cih.1_Silent_p.L383L|FBXW7_uc003imq.2_Silent_p.L479L|FBXW7_uc003imr.2_Silent_p.L441L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	559	WD 5.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)						Mis|N|D|F		colorectal|endometrial|T-ALL								---	---	---	---
RNF175	285533	broad.mit.edu	37	4	154649450	154649450	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154649450G>A	uc003int.2	-	4	683	c.310C>T	c.(310-312)CGG>TGG	p.R104W	RNF175_uc003inu.1_Intron	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	104	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)																---	---	---	---
DCHS2	54798	broad.mit.edu	37	4	155163803	155163803	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155163803T>C	uc003inw.2	-	22	5698	c.5698A>G	c.(5698-5700)ATT>GTT	p.I1900V		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1900	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)														---	---	---	---
PLRG1	5356	broad.mit.edu	37	4	155463418	155463418	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155463418T>C	uc003iny.2	-	8	671	c.608A>G	c.(607-609)CAT>CGT	p.H203R	PLRG1_uc003inz.2_Missense_Mutation_p.H194R|PLRG1_uc011cil.1_Missense_Mutation_p.H42R	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	203	WD 1.					catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)																---	---	---	---
TRIM60	166655	broad.mit.edu	37	4	165961252	165961252	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:165961252C>A	uc003iqy.1	+	3	198	c.28C>A	c.(28-30)CTC>ATC	p.L10I	TRIM60_uc010iqx.1_Missense_Mutation_p.L10I	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	10						intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)														---	---	---	---
WDR17	116966	broad.mit.edu	37	4	177056319	177056319	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:177056319A>G	uc003iuj.2	+	9	1387	c.1231A>G	c.(1231-1233)ACA>GCA	p.T411A	WDR17_uc003iuk.2_Missense_Mutation_p.T387A|WDR17_uc003ium.3_Missense_Mutation_p.T387A|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	411	WD 6.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)														---	---	---	---
VEGFC	7424	broad.mit.edu	37	4	177649058	177649058	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:177649058C>T	uc003ius.1	-	3	856	c.426G>A	c.(424-426)AAG>AAA	p.K142K		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	142					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183574966	183574966	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183574966A>C	uc003ivd.1	+	5	1068	c.1031A>C	c.(1030-1032)GAA>GCA	p.E344A		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	344	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
STOX2	56977	broad.mit.edu	37	4	184931564	184931564	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184931564C>A	uc003ivz.1	+	3	3008	c.1573C>A	c.(1573-1575)CAA>AAA	p.Q525K	STOX2_uc003iwa.1_Missense_Mutation_p.Q214K	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	525					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)														---	---	---	---
ZFP42	132625	broad.mit.edu	37	4	188924640	188924640	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:188924640G>A	uc003izg.1	+	3	924	c.679G>A	c.(679-681)GTT>ATT	p.V227I	ZFP42_uc003izh.1_Missense_Mutation_p.V227I|ZFP42_uc003izi.1_Missense_Mutation_p.V227I	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	227	C2H2-type 2.				female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)														---	---	---	---
TRIML2	205860	broad.mit.edu	37	4	189012969	189012969	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:189012969G>A	uc003izl.2	-	7	758	c.722C>T	c.(721-723)GCC>GTC	p.A241V	TRIML2_uc003izj.1_Missense_Mutation_p.A69V|TRIML2_uc003izk.1_Missense_Mutation_p.A49V|TRIML2_uc011cle.1_Missense_Mutation_p.A316V	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	241	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)														---	---	---	---
TRIML1	339976	broad.mit.edu	37	4	189060814	189060814	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:189060814C>T	uc003izm.1	+	1	217	c.102C>T	c.(100-102)AGC>AGT	p.S34S		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	34	RING-type.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)														---	---	---	---
PLEKHG4B	153478	broad.mit.edu	37	5	182314	182314	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:182314G>A	uc003jak.2	+	18	3742	c.3692G>A	c.(3691-3693)TGG>TAG	p.W1231*		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1231	Ser-rich.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)														---	---	---	---
KIAA0947	23379	broad.mit.edu	37	5	5469044	5469044	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5469044G>A	uc003jdm.3	+	15	6387	c.6165G>A	c.(6163-6165)AGG>AGA	p.R2055R		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2055										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
PAPD7	11044	broad.mit.edu	37	5	6746416	6746416	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:6746416T>C	uc003jdx.1	+	7	714	c.585T>C	c.(583-585)AAT>AAC	p.N195N	PAPD7_uc011cmn.1_Silent_p.N186N|PAPD7_uc010itl.1_Silent_p.N15N	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	195	PAP-associated.				cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1																OREG0016494	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14363893	14363893	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14363893A>G	uc003jff.2	+	14	2450	c.2444A>G	c.(2443-2445)GAC>GGC	p.D815G	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.D766G|TRIO_uc003jfh.1_Missense_Mutation_p.D464G	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	815					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
CDH12	1010	broad.mit.edu	37	5	21752243	21752243	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:21752243T>C	uc010iuc.2	-	12	2446	c.1988A>G	c.(1987-1989)GAA>GGA	p.E663G	CDH12_uc011cno.1_Missense_Mutation_p.E623G|CDH12_uc003jgk.2_Missense_Mutation_p.E663G|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	663	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2															HNSCC(59;0.17)			---	---	---	---
CDH12	1010	broad.mit.edu	37	5	21755909	21755909	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:21755909C>T	uc010iuc.2	-	11	2134	c.1676G>A	c.(1675-1677)CGC>CAC	p.R559H	CDH12_uc011cno.1_Missense_Mutation_p.R519H|CDH12_uc003jgk.2_Missense_Mutation_p.R559H|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	559	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2															HNSCC(59;0.17)			---	---	---	---
NPR3	4883	broad.mit.edu	37	5	32712163	32712163	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32712163C>A	uc003jhv.2	+	1	499	c.281C>A	c.(280-282)CCG>CAG	p.P94Q	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.P94Q	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	94	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)													---	---	---	---
DNAJC21	134218	broad.mit.edu	37	5	34937566	34937566	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:34937566C>T	uc003jjc.2	+	5	801	c.574C>T	c.(574-576)CGG>TGG	p.R192W	DNAJC21_uc003jjb.2_Missense_Mutation_p.R192W|DNAJC21_uc010iuu.1_Missense_Mutation_p.R76W	NM_001012339	NP_001012339	Q5F1R6	DJC21_HUMAN	DnaJ homology subfamily A member 5 isoform 2	192					protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|skin(1)	2	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)															---	---	---	---
UGT3A1	133688	broad.mit.edu	37	5	35954433	35954433	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35954433A>G	uc003jjv.1	-	7	1600	c.1443T>C	c.(1441-1443)CAT>CAC	p.H481H	UGT3A1_uc003jjw.1_RNA	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	481	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37022159	37022159	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37022159C>T	uc003jkl.3	+	28	5834	c.5335C>T	c.(5335-5337)CGA>TGA	p.R1779*	NIPBL_uc003jkk.3_Nonsense_Mutation_p.R1779*	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1779	HEAT 1.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
CDC20B	166979	broad.mit.edu	37	5	54468411	54468411	+	Intron	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54468411C>G	uc003jpo.1	-						CDC20B_uc003jpn.1_Intron|CDC20B_uc010ivu.1_Intron|CDC20B_uc010ivv.1_Intron|CDC20B_uc003jpp.2_Intron|MIR449A_hsa-mir-449a|MI0001648_5'Flank|uc011cqh.1_5'Flank|MIR449B_hsa-mir-449b|MI0003673_5'Flank|MIR449C_hsa-mir-449c|MI0003823_5'Flank	NM_152623	NP_689836			CDC20 cell division cycle 20 homolog B isoform												0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)															---	---	---	---
SGTB	54557	broad.mit.edu	37	5	65016588	65016588	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65016588C>T	uc003jud.2	-	2	267	c.47G>A	c.(46-48)CGG>CAG	p.R16Q	NLN_uc003jue.2_5'Flank|NLN_uc003juf.2_5'Flank	NM_019072	NP_061945	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat	16	TPR 1.						binding				0		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)														---	---	---	---
CRHBP	1393	broad.mit.edu	37	5	76250013	76250013	+	Splice_Site	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:76250013T>C	uc003ker.2	+	3	613	c.333_splice	c.e3+2	p.K111_splice	CRHBP_uc010izx.2_Splice_Site_p.K111_splice	NM_001882	NP_001873			corticotropin releasing hormone binding protein						female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)														---	---	---	---
PAPD4	167153	broad.mit.edu	37	5	78981033	78981033	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:78981033A>T	uc010jae.1	+	16	1810	c.1392A>T	c.(1390-1392)AGA>AGT	p.R464S	PAPD4_uc003kgb.2_Missense_Mutation_p.R464S|PAPD4_uc010jaf.1_Missense_Mutation_p.R464S|PAPD4_uc003kga.2_Missense_Mutation_p.R460S|PAPD4_uc003kfz.2_Missense_Mutation_p.R421S	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	464					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)														---	---	---	---
RASA1	5921	broad.mit.edu	37	5	86629108	86629108	+	Nonsense_Mutation	SNP	C	T	T	rs137853218		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:86629108C>T	uc003kiw.2	+	4	971	c.853C>T	c.(853-855)CGA>TGA	p.R285*	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Nonsense_Mutation_p.R108*|RASA1_uc011ctv.1_Nonsense_Mutation_p.R118*|RASA1_uc011ctw.1_Nonsense_Mutation_p.R119*|RASA1_uc010jaw.2_Nonsense_Mutation_p.R108*	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	285	SH3.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)														---	---	---	---
MCTP1	79772	broad.mit.edu	37	5	94204160	94204160	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94204160G>A	uc003kkx.2	-						MCTP1_uc003kkv.2_Intron|MCTP1_uc003kkw.2_Intron|MCTP1_uc003kkz.2_Intron|MCTP1_uc003kku.2_Intron	NM_024717	NP_078993			multiple C2 domains, transmembrane 1 isoform L						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)														---	---	---	---
LIX1	167410	broad.mit.edu	37	5	96430680	96430680	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96430680G>T	uc003kmy.3	-	6	861	c.621C>A	c.(619-621)GCC>GCA	p.A207A		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	limb expression 1	207										ovary(1)	1		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)														---	---	---	---
CHD1	1105	broad.mit.edu	37	5	98206418	98206418	+	Silent	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:98206418A>C	uc003knf.2	-	28	4099	c.3951T>G	c.(3949-3951)CTT>CTG	p.L1317L	CHD1_uc010jbn.2_Silent_p.L43L	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1317					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)													---	---	---	---
SLCO4C1	353189	broad.mit.edu	37	5	101582950	101582950	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:101582950A>G	uc003knm.2	-							NM_180991	NP_851322			solute carrier organic anion transporter family,						cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)														---	---	---	---
SLCO6A1	133482	broad.mit.edu	37	5	101735414	101735414	+	Silent	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:101735414T>A	uc003knn.2	-	10	1831	c.1659A>T	c.(1657-1659)GGA>GGT	p.G553G	SLCO6A1_uc003kno.2_Silent_p.G300G|SLCO6A1_uc003knp.2_Silent_p.G553G|SLCO6A1_uc003knq.2_Silent_p.G491G	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	553	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)														---	---	---	---
WDR36	134430	broad.mit.edu	37	5	110440035	110440035	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110440035C>A	uc003kpd.2	+	8	1175	c.1058C>A	c.(1057-1059)GCT>GAT	p.A353D	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	353	WD 4.				response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)														---	---	---	---
EPB41L4A	64097	broad.mit.edu	37	5	111570349	111570349	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:111570349C>A	uc003kpv.1	-	12	1343	c.1069G>T	c.(1069-1071)GCA>TCA	p.A357S		NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	357						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)														---	---	---	---
MCC	4163	broad.mit.edu	37	5	112364690	112364690	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112364690G>A	uc003kqj.3	-	16	2780	c.2250C>T	c.(2248-2250)AGC>AGT	p.S750S	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Silent_p.S940S	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	750					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)														---	---	---	---
YTHDC2	64848	broad.mit.edu	37	5	112902884	112902884	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112902884T>C	uc003kqn.2	+	22	3121	c.2938T>C	c.(2938-2940)TAT>CAT	p.Y980H		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	980							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)														---	---	---	---
SRFBP1	153443	broad.mit.edu	37	5	121355909	121355909	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:121355909G>A	uc003kst.1	+	6	551	c.479G>A	c.(478-480)CGT>CAT	p.R160H		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	160					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)														---	---	---	---
FSTL4	23105	broad.mit.edu	37	5	132648366	132648366	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132648366C>T	uc003kyn.1	-	6	925	c.707G>A	c.(706-708)CGC>CAC	p.R236H		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	236						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
KDM3B	51780	broad.mit.edu	37	5	137729022	137729022	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137729022A>G	uc003lcy.1	+	9	2992	c.2792A>G	c.(2791-2793)GAT>GGT	p.D931G	KDM3B_uc010jew.1_Missense_Mutation_p.D587G|KDM3B_uc011cys.1_5'UTR	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	931					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11																		---	---	---	---
EGR1	1958	broad.mit.edu	37	5	137802740	137802740	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137802740C>A	uc003ldb.1	+	2	872	c.602C>A	c.(601-603)CCC>CAC	p.P201H	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	201					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)															---	---	---	---
PCDHA4	56144	broad.mit.edu	37	5	140187861	140187861	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140187861T>C	uc003lhi.2	+	1	1190	c.1089T>C	c.(1087-1089)GCT>GCC	p.A363A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.A363A|PCDHA4_uc011daa.1_Silent_p.A363A	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	363	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA5	56143	broad.mit.edu	37	5	140202795	140202795	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140202795C>T	uc003lhl.2	+	1	1435	c.1435C>T	c.(1435-1437)CGG>TGG	p.R479W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R479W|PCDHA5_uc003lhj.1_Missense_Mutation_p.R479W	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	479	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA9	9752	broad.mit.edu	37	5	140228550	140228550	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140228550C>T	uc003lhu.2	+	1	1194	c.470C>T	c.(469-471)GCG>GTG	p.A157V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.A157V	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	157	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA10	56139	broad.mit.edu	37	5	140237067	140237067	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140237067G>A	uc003lhx.2	+	1	1434	c.1434G>A	c.(1432-1434)GCG>GCA	p.A478A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.A478A|PCDHA10_uc011dad.1_Silent_p.A478A	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	478	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA11	56138	broad.mit.edu	37	5	140250883	140250883	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140250883C>T	uc003lia.2	+	1	3053	c.2195C>T	c.(2194-2196)GCG>GTG	p.A732V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A732V	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	732	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHB6	56130	broad.mit.edu	37	5	140531449	140531449	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140531449G>A	uc003lir.2	+	1	1611	c.1611G>A	c.(1609-1611)CCG>CCA	p.P537P	PCDHB6_uc011dah.1_Silent_p.P401P	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	537	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB13	56123	broad.mit.edu	37	5	140594940	140594940	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140594940G>A	uc003lja.1	+	1	1432	c.1245G>A	c.(1243-1245)GCG>GCA	p.A415A		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	415	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHGB1	56104	broad.mit.edu	37	5	140731723	140731723	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140731723C>T	uc003ljo.1	+	1	1896	c.1896C>T	c.(1894-1896)GAC>GAT	p.D632D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Silent_p.D632D	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	632	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGB2	56103	broad.mit.edu	37	5	140739873	140739873	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140739873C>T	uc003ljs.1	+	1	171	c.171C>T	c.(169-171)AGC>AGT	p.S57S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Silent_p.S57S	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	57	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGB4	8641	broad.mit.edu	37	5	140769248	140769248	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140769248C>T	uc003lkc.1	+	1	1797	c.1797C>T	c.(1795-1797)AAC>AAT	p.N599N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.N599N	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	599	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA8	9708	broad.mit.edu	37	5	140772597	140772597	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140772597C>T	uc003lkd.1	+	1	1115	c.217C>T	c.(217-219)CAG>TAG	p.Q73*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Nonsense_Mutation_p.Q73*	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	73	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA12	26025	broad.mit.edu	37	5	140812558	140812558	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140812558C>T	uc003lkt.1	+	1	2401	c.2232C>T	c.(2230-2232)GAC>GAT	p.D744D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Silent_p.D744D	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	744	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
FCHSD1	89848	broad.mit.edu	37	5	141028998	141028998	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141028998A>G	uc003llk.2	-	5	390	c.339T>C	c.(337-339)GGT>GGC	p.G113G	FCHSD1_uc010jgg.2_5'Flank|FCHSD1_uc003llj.2_RNA	NM_033449	NP_258260	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	113									FCHSD1/BRAF(2)	skin(2)|ovary(1)|central_nervous_system(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDH1	5097	broad.mit.edu	37	5	141233894	141233894	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141233894G>T	uc003llp.2	-	5	3544	c.3427C>A	c.(3427-3429)CGC>AGC	p.R1143S		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)														---	---	---	---
SPINK5	11005	broad.mit.edu	37	5	147499622	147499622	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147499622C>T	uc003lox.2	+	25	2437	c.2364C>T	c.(2362-2364)TGC>TGT	p.C788C	SPINK5_uc010jgr.2_Silent_p.C769C|SPINK5_uc003low.2_Silent_p.C788C|SPINK5_uc003loy.2_Silent_p.C788C	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	788	Kazal-like 12.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCYOX1L	78991	broad.mit.edu	37	5	148747916	148747916	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148747916G>A	uc003lqk.2	+	6	1246	c.1184G>A	c.(1183-1185)CGA>CAA	p.R395Q	PCYOX1L_uc003lql.2_Missense_Mutation_p.R378Q|PCYOX1L_uc010jgz.2_Missense_Mutation_p.R319Q|PCYOX1L_uc003lqm.2_Missense_Mutation_p.R277Q|PCYOX1L_uc003lqn.2_Missense_Mutation_p.R305Q	NM_024028	NP_076933	Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like precursor	395					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)													OREG0016912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PDE6A	5145	broad.mit.edu	37	5	149314176	149314176	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149314176C>T	uc003lrg.3	-	2	700	c.580G>A	c.(580-582)GCT>ACT	p.A194T		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	194	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)															---	---	---	---
SLC36A3	285641	broad.mit.edu	37	5	150682787	150682787	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150682787C>T	uc003ltw.2	-						GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltx.2_Intron	NM_181774	NP_861439			solute carrier family 36, member 3 isoform 2							integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
FAT2	2196	broad.mit.edu	37	5	150887067	150887067	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150887067G>A	uc003lue.3	-	22	12178	c.12165C>T	c.(12163-12165)GCC>GCT	p.A4055A	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Silent_p.A662A	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	4055	Helical; (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
ITK	3702	broad.mit.edu	37	5	156608073	156608073	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156608073C>T	uc003lwo.1	+	1	167	c.85C>T	c.(85-87)CGC>TGC	p.R29C		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	29	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)					T	SYK	peripheral T-cell lymphoma								---	---	---	---
SOX30	11063	broad.mit.edu	37	5	157078490	157078490	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:157078490C>T	uc003lxb.1	-	1	939	c.597G>A	c.(595-597)GGG>GGA	p.G199G	SOX30_uc003lxc.1_Silent_p.G199G|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	199					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
RNF145	153830	broad.mit.edu	37	5	158588398	158588398	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158588398C>T	uc003lxp.2	-	10	1815	c.1502G>A	c.(1501-1503)CGG>CAG	p.R501Q	RNF145_uc011ddy.1_Missense_Mutation_p.R515Q|RNF145_uc003lxo.1_Missense_Mutation_p.R529Q|RNF145_uc011ddz.1_Missense_Mutation_p.R518Q|RNF145_uc010jiq.1_Missense_Mutation_p.R531Q	NM_144726	NP_653327	Q96MT1	RN145_HUMAN	ring finger protein 145	501	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
FABP6	2172	broad.mit.edu	37	5	159661892	159661892	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:159661892G>T	uc003lya.1	+	3	437	c.309G>T	c.(307-309)GAG>GAT	p.E103D	FABP6_uc003lxx.1_Missense_Mutation_p.E152D|FABP6_uc003lxz.1_Missense_Mutation_p.E152D	NM_001445	NP_001436	P51161	FABP6_HUMAN	gastrotropin isoform 2	103					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
ODZ2	57451	broad.mit.edu	37	5	167182202	167182202	+	Intron	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167182202G>T	uc010jjd.2	+						ODZ2_uc003lzq.2_Intron|ODZ2_uc003lzr.3_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)														---	---	---	---
DOCK2	1794	broad.mit.edu	37	5	169081502	169081502	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:169081502G>A	uc003maf.2	+						DOCK2_uc011der.1_Intron	NM_004946	NP_004937			dedicator of cytokinesis 2						actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
GABRP	2568	broad.mit.edu	37	5	170232795	170232795	+	Missense_Mutation	SNP	G	A	A	rs150667747		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170232795G>A	uc003mau.2	+	7	815	c.617G>A	c.(616-618)CGG>CAG	p.R206Q	GABRP_uc011dev.1_Missense_Mutation_p.R206Q	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	206	Extracellular (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
DDX41	51428	broad.mit.edu	37	5	176940713	176940713	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176940713G>A	uc003mho.2	-	10	1092	c.1071C>T	c.(1069-1071)GAC>GAT	p.D357D	DDX41_uc003mhm.2_Silent_p.D137D|DDX41_uc003mhn.2_Silent_p.D226D|DDX41_uc003mhp.2_Silent_p.D226D|DDX41_uc003mhq.1_Silent_p.D137D	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	357	Helicase ATP-binding.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)															---	---	---	---
GRM6	2916	broad.mit.edu	37	5	178410138	178410138	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178410138G>T	uc003mjr.2	-	9	2388	c.2209C>A	c.(2209-2211)CAG>AAG	p.Q737K	GRM6_uc003mjq.2_Missense_Mutation_p.Q140K	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	737	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)														---	---	---	---
GRM6	2916	broad.mit.edu	37	5	178415995	178415995	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178415995G>A	uc003mjr.2	-	6	1474	c.1295C>T	c.(1294-1296)GCG>GTG	p.A432V	GRM6_uc010jla.1_Missense_Mutation_p.A15V|GRM6_uc003mjs.1_Missense_Mutation_p.A52V	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	432	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)														---	---	---	---
FLT4	2324	broad.mit.edu	37	5	180047711	180047711	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180047711G>A	uc003mma.3	-	16	2383	c.2304C>T	c.(2302-2304)TCC>TCT	p.S768S	FLT4_uc003mlz.3_Silent_p.S768S|FLT4_uc003mmb.1_Silent_p.S301S	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	768	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)									Congenital_Hereditary_Lymphedema				---	---	---	---
TRIM7	81786	broad.mit.edu	37	5	180626983	180626983	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180626983C>A	uc003mmz.1	-	3	784	c.717G>T	c.(715-717)GAG>GAT	p.E239D	TRIM7_uc003mmv.1_Missense_Mutation_p.E57D|TRIM7_uc003mmw.1_Missense_Mutation_p.E31D|TRIM7_uc003mmx.1_Missense_Mutation_p.E31D|TRIM7_uc003mmy.1_Missense_Mutation_p.E31D	NM_203293	NP_976038	Q9C029	TRIM7_HUMAN	tripartite motif-containing 7 isoform 1	239	Potential.					cytoplasm|nucleus	zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)														---	---	---	---
F13A1	2162	broad.mit.edu	37	6	6318878	6318878	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:6318878G>A	uc003mwv.2	-	2	143	c.20C>T	c.(19-21)ACC>ATC	p.T7I	F13A1_uc011dib.1_Missense_Mutation_p.T7I	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	7					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)													---	---	---	---
RREB1	6239	broad.mit.edu	37	6	7240812	7240812	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7240812A>G	uc003mxc.2	+						RREB1_uc003mxb.2_Missense_Mutation_p.D1317G|RREB1_uc010jnx.2_Missense_Mutation_p.D1317G	NM_001003698	NP_001003698			ras responsive element binding protein 1 isoform						multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)																---	---	---	---
DSP	1832	broad.mit.edu	37	6	7585229	7585229	+	Silent	SNP	C	T	T	rs28763970	byFrequency;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7585229C>T	uc003mxp.1	+	24	8013	c.7734C>T	c.(7732-7734)AGC>AGT	p.S2578S	DSP_uc003mxq.1_Silent_p.S1979S	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2578	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)														---	---	---	---
C6orf218	221718	broad.mit.edu	37	6	10430484	10430484	+	RNA	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:10430484C>T	uc003myz.2	-	3		c.552G>A				NR_027793				Homo sapiens chromosome 6 open reading frame 218, mRNA (cDNA clone IMAGE:3917693).												0	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.124)																---	---	---	---
RBM24	221662	broad.mit.edu	37	6	17283113	17283113	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17283113C>T	uc003nbz.3	+	2	250	c.246C>T	c.(244-246)AAC>AAT	p.N82N	RBM24_uc003nby.3_Silent_p.N82N|RBM24_uc011dix.1_Silent_p.N24N|RBM24_uc003nca.2_Silent_p.N37N	NM_001143942	NP_001137414	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24 isoform 1	82	RRM.				cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			ovary(1)|skin(1)	2	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)															---	---	---	---
KIF13A	63971	broad.mit.edu	37	6	17826300	17826300	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17826300G>A	uc003ncg.3	-	15	1693	c.1588C>T	c.(1588-1590)CGA>TGA	p.R530*	KIF13A_uc003ncf.2_Nonsense_Mutation_p.R530*|KIF13A_uc003nch.3_Nonsense_Mutation_p.R530*|KIF13A_uc003nci.3_Nonsense_Mutation_p.R530*|KIF13A_uc003ncj.2_Nonsense_Mutation_p.R206*	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	530					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)															---	---	---	---
DCDC2	51473	broad.mit.edu	37	6	24175061	24175061	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24175061G>T	uc003ndx.2	-	10	1630	c.1328C>A	c.(1327-1329)GCT>GAT	p.A443D	DCDC2_uc003ndy.2_Missense_Mutation_p.A443D|DCDC2_uc003ndw.2_Missense_Mutation_p.A194D	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	443					cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)																---	---	---	---
ALDH5A1	7915	broad.mit.edu	37	6	24528248	24528248	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24528248C>T	uc003neg.2	+	8	1225	c.1197C>T	c.(1195-1197)GCC>GCT	p.A399A	ALDH5A1_uc003nef.2_Silent_p.A412A	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	399					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)													---	---	---	---
LRRC16A	55604	broad.mit.edu	37	6	25540216	25540216	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:25540216G>A	uc011djw.1	+	26	2614	c.2238G>A	c.(2236-2238)GCG>GCA	p.A746A	LRRC16A_uc010jpx.2_Silent_p.A746A|LRRC16A_uc010jpy.2_Silent_p.A746A|LRRC16A_uc003nfa.1_Silent_p.A100A	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	746					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
SLC17A2	10246	broad.mit.edu	37	6	25913516	25913516	+	3'UTR	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:25913516A>G	uc011dkb.1	-	11					SLC17A2_uc011dkc.1_3'UTR|SLC17A2_uc003nfl.2_3'UTR					SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;						phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1																		---	---	---	---
HIST1H2BB	3018	broad.mit.edu	37	6	26043776	26043776	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26043776C>A	uc003nfu.2	-	1	110	c.110G>T	c.(109-111)AGC>ATC	p.S37I	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	37					nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---
BTN2A1	11120	broad.mit.edu	37	6	26468202	26468202	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26468202G>A	uc003nib.1	+	8	1221	c.1009G>A	c.(1009-1011)GCT>ACT	p.A337T	BTN2A1_uc003nic.1_3'UTR|BTN2A1_uc003nid.1_Missense_Mutation_p.A185T|BTN2A1_uc011dko.1_Missense_Mutation_p.A276T|BTN2A1_uc010jqk.1_Missense_Mutation_p.A97T	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	337	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
PGBD1	84547	broad.mit.edu	37	6	28269790	28269790	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28269790T>A	uc003nky.2	+	7	2529	c.2159T>A	c.(2158-2160)ATC>AAC	p.I720N	PGBD1_uc003nkz.2_Missense_Mutation_p.I720N	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	720					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4																		---	---	---	---
SCAND3	114821	broad.mit.edu	37	6	28541299	28541299	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28541299T>C	uc003nlo.2	-	4	2985	c.2367A>G	c.(2365-2367)TCA>TCG	p.S789S		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	789					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
OR2B3	442184	broad.mit.edu	37	6	29054462	29054462	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29054462T>C	uc003nlx.2	-	1	629	c.564A>G	c.(562-564)TCA>TCG	p.S188S		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1																		---	---	---	---
MAS1L	116511	broad.mit.edu	37	6	29455673	29455673	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29455673A>G	uc011dlq.1	-	1	7	c.7T>C	c.(7-9)TGG>CGG	p.W3R		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	3	Extracellular (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9																		---	---	---	---
ZFP57	346171	broad.mit.edu	37	6	29641061	29641061	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29641061C>T	uc011dlw.1	-	4	978	c.827G>A	c.(826-828)CGC>CAC	p.R276H	ZFP57_uc003nnl.3_Missense_Mutation_p.R256H	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	192	C2H2-type 4.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding	p.R276R(1)		ovary(3)|skin(2)	5																		---	---	---	---
HLA-G	3135	broad.mit.edu	37	6	29795994	29795994	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29795994G>A	uc003nnw.2	+	3	422	c.244G>A	c.(244-246)GAG>AAG	p.E82K	HLA-G_uc011dmb.1_Missense_Mutation_p.E54K|HLA-G_uc003raj.3_Missense_Mutation_p.E87K|HLA-G_uc003nnz.3_Missense_Mutation_p.E82K|HLA-G_uc010jrn.2_Missense_Mutation_p.E82K|HLA-G_uc003nny.3_RNA|HLA-G_uc003ran.1_5'Flank	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	82	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
MDC1	9656	broad.mit.edu	37	6	30671881	30671881	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30671881C>T	uc003nrg.3	-	10	5519	c.5079G>A	c.(5077-5079)CCG>CCA	p.P1693P	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Silent_p.P1300P	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1693					cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4													Other_conserved_DNA_damage_response_genes					---	---	---	---
VARS2	57176	broad.mit.edu	37	6	30890973	30890973	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30890973T>C	uc003nsc.1	+	23	2910	c.2278T>C	c.(2278-2280)TTA>CTA	p.L760L	VARS2_uc011dmx.1_Silent_p.L760L|VARS2_uc011dmy.1_Silent_p.L620L|VARS2_uc011dmz.1_Silent_p.L790L|VARS2_uc011dna.1_Silent_p.L758L|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_Silent_p.L198L|VARS2_uc010jsg.1_Silent_p.L132L|VARS2_uc010jsh.1_5'UTR	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	760					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
ATP6V1G2	534	broad.mit.edu	37	6	31513913	31513913	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31513913C>A	uc003nua.2	-	2	447	c.156G>T	c.(154-156)GAG>GAT	p.E52D	BAT1_uc003ntv.2_5'UTR|ATP6V1G2_uc003ntz.2_Missense_Mutation_p.E11D|NFKBIL1_uc011dnr.1_5'Flank|NFKBIL1_uc011dns.1_5'Flank|NFKBIL1_uc011dnt.1_5'Flank|NFKBIL1_uc003nuc.2_5'Flank|NFKBIL1_uc003nub.2_5'Flank	NM_130463	NP_569730	O95670	VATG2_HUMAN	ATPase, H+ transporting, lysosomal, V1 subunit	52					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|melanosome|vacuolar proton-transporting V-type ATPase complex	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|protein binding				0																		---	---	---	---
EHMT2	10919	broad.mit.edu	37	6	31855364	31855364	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31855364G>A	uc003nxz.1	-	15	2011	c.2001C>T	c.(1999-2001)ATC>ATT	p.I667I	EHMT2_uc003nxv.1_5'Flank|EHMT2_uc003nxw.1_5'Flank|EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Silent_p.I458I|EHMT2_uc011don.1_Silent_p.I690I|EHMT2_uc003nya.1_Silent_p.I633I	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	667	ANK 1.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1																		---	---	---	---
C4A	720	broad.mit.edu	37	6	31994882	31994882	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31994882C>T	uc011dpd.1	+	20	2626	c.2575C>T	c.(2575-2577)CTG>TTG	p.L859L	C4A_uc011dpe.1_Silent_p.L859L	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	859					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0																		---	---	---	---
PPT2	9374	broad.mit.edu	37	6	32130334	32130334	+	Intron	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32130334T>A	uc003nzx.2	+						PPT2_uc003nzw.2_Intron|PPT2_uc011dpi.1_Intron|PPT2_uc003nzy.1_Intron|PPT2_uc003nzz.2_Intron|PPT2_uc003oaa.2_Intron|PPT2_uc010jtu.1_Intron|EGFL8_uc003oac.1_5'Flank|EGFL8_uc003oab.1_5'Flank	NM_005155	NP_005146			palmitoyl-protein thioesterase 2 isoform a						protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0																		---	---	---	---
NOTCH4	4855	broad.mit.edu	37	6	32164828	32164828	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32164828T>C	uc003obb.2	-	28	5213	c.5074A>G	c.(5074-5076)ACT>GCT	p.T1692A	GPSM3_uc003oaz.2_5'Flank|NOTCH4_uc011dpt.1_Missense_Mutation_p.T101A|NOTCH4_uc003oba.2_Missense_Mutation_p.T352A|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_Missense_Mutation_p.T101A	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1692	Cytoplasmic (Potential).|ANK 2.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22																		---	---	---	---
HLA-DRA	3122	broad.mit.edu	37	6	32410443	32410443	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32410443C>T	uc003obh.2	+	2	382	c.301C>T	c.(301-303)CGC>TGC	p.R101C	HLA-DRA_uc003obi.2_Missense_Mutation_p.R101C	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	101	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2														T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Kaposi_Sarcoma_Familial_Clustering_of				---	---	---	---
BRD2	6046	broad.mit.edu	37	6	32943277	32943277	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32943277C>T	uc003ocn.3	+	4	2151	c.450C>T	c.(448-450)ACC>ACT	p.T150T	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.T150T|BRD2_uc003ocp.3_Silent_p.T30T|BRD2_uc010juh.2_Silent_p.T150T	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	150	Bromo 1.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5																		---	---	---	---
WDR46	9277	broad.mit.edu	37	6	33255222	33255222	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33255222G>A	uc003ods.2	-	8	833	c.789C>T	c.(787-789)GAC>GAT	p.D263D	WDR46_uc011dra.1_Silent_p.D209D|WDR46_uc010juo.1_RNA|PFDN6_uc003odt.1_5'Flank|PFDN6_uc010jup.1_5'Flank	NM_005452	NP_005443	O15213	WDR46_HUMAN	WD repeat domain 46 isoform 1	263	WD 2.										0																		---	---	---	---
ITPR3	3710	broad.mit.edu	37	6	33658716	33658716	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33658716A>G	uc011drk.1	+	52	7274	c.7055A>G	c.(7054-7056)GAG>GGG	p.E2352G	ITPR3_uc003oey.2_Missense_Mutation_p.E439G	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2352	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19																		---	---	---	---
SRPK1	6732	broad.mit.edu	37	6	35825051	35825051	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35825051C>T	uc003olj.2	-	13	1730	c.1607G>A	c.(1606-1608)AGC>AAC	p.S536N	SRPK1_uc011dtg.1_Missense_Mutation_p.S520N|SRPK1_uc003olh.2_Missense_Mutation_p.S429N|SRPK1_uc003oli.2_Missense_Mutation_p.S429N	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	536	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1																		---	---	---	---
PIM1	5292	broad.mit.edu	37	6	37139205	37139205	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37139205T>C	uc003onk.2	+	4	975	c.545T>C	c.(544-546)CTC>CCC	p.L182P	PIM1_uc011dtw.1_5'Flank	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	273	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)			T	BCL6	NHL								---	---	---	---
FTSJD2	23070	broad.mit.edu	37	6	37445388	37445388	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37445388T>C	uc003ons.2	+	21	2379	c.2126T>C	c.(2125-2127)CTG>CCG	p.L709P		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	709					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
GLP1R	2740	broad.mit.edu	37	6	39041530	39041530	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:39041530G>A	uc003ooj.3	+	7	868	c.808G>A	c.(808-810)GTG>ATG	p.V270M	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	270	Helical; Name=4; (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)													---	---	---	---
FOXP4	116113	broad.mit.edu	37	6	41533642	41533642	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41533642G>A	uc003oql.2	+	2	602	c.144G>A	c.(142-144)ACG>ACA	p.T48T	FOXP4_uc003oqm.2_Silent_p.T48T|FOXP4_uc003oqn.2_Silent_p.T48T	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	48					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)																	---	---	---	---
PRICKLE4	29964	broad.mit.edu	37	6	41753259	41753259	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41753259G>A	uc011duf.1	+	6	811	c.563G>A	c.(562-564)CGC>CAC	p.R188H	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_5'Flank|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	148	LIM zinc-binding 2.					nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)															---	---	---	---
TRERF1	55809	broad.mit.edu	37	6	42231260	42231260	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42231260G>A	uc003osd.2	-	8	2245	c.1682C>T	c.(1681-1683)CCG>CTG	p.P561L	TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Missense_Mutation_p.P561L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	561	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)															---	---	---	---
GNMT	27232	broad.mit.edu	37	6	42930849	42930849	+	Missense_Mutation	SNP	C	T	T	rs139815680		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42930849C>T	uc003otd.2	+	4	497	c.491C>T	c.(490-492)GCG>GTG	p.A164V	uc003ote.1_5'Flank	NM_018960	NP_061833	Q14749	GNMT_HUMAN	glycine N-methyltransferase	164					protein homotetramerization|protein modification process|S-adenosylmethionine metabolic process		folic acid binding|glycine binding|glycine N-methyltransferase activity				0	Colorectal(47;0.196)		all cancers(41;0.00196)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0461)		Glycine(DB00145)|S-Adenosylmethionine(DB00118)													---	---	---	---
SLC22A7	10864	broad.mit.edu	37	6	43271811	43271811	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43271811G>A	uc003out.2	+	10	1520	c.1421G>A	c.(1420-1422)CGG>CAG	p.R474Q	SLC22A7_uc003ous.2_Missense_Mutation_p.R472Q	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	474	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)															---	---	---	---
CD2AP	23607	broad.mit.edu	37	6	47563667	47563667	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:47563667T>C	uc003oyw.2	+	12	1635	c.1179T>C	c.(1177-1179)ACT>ACC	p.T393T		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	393	Pro-rich.|SH3-binding (Potential).				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)															---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51774069	51774069	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51774069G>A	uc003pah.1	-						PKHD1_uc010jzn.1_Intron|PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
HMGCLL1	54511	broad.mit.edu	37	6	55300543	55300543	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:55300543C>T	uc003pcn.2	-	10	1189	c.1030G>A	c.(1030-1032)GTG>ATG	p.V344M	HMGCLL1_uc003pco.2_Missense_Mutation_p.V314M|HMGCLL1_uc010jzx.2_Missense_Mutation_p.V215M|HMGCLL1_uc011dxc.1_Missense_Mutation_p.V282M|HMGCLL1_uc011dxd.1_Missense_Mutation_p.V211M|HMGCLL1_uc011dxe.1_Missense_Mutation_p.V148M	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	344							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)															---	---	---	---
BMP5	653	broad.mit.edu	37	6	55620338	55620338	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:55620338C>A	uc003pcq.2	-	7	2070	c.1358G>T	c.(1357-1359)TGC>TTC	p.C453F	BMP5_uc011dxf.1_Missense_Mutation_p.C416F	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	453					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)															---	---	---	---
DST	667	broad.mit.edu	37	6	56506814	56506814	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56506814C>T	uc003pdf.2	-	16	1887	c.1859G>A	c.(1858-1860)CGC>CAC	p.R620H	DST_uc003pcz.3_Missense_Mutation_p.R442H|DST_uc011dxj.1_Missense_Mutation_p.R471H|DST_uc011dxk.1_Missense_Mutation_p.R482H|DST_uc011dxl.1_Missense_Mutation_p.R471H|DST_uc003pcy.3_Missense_Mutation_p.R116H|DST_uc003pdb.2_Missense_Mutation_p.R116H|DST_uc003pdc.3_Missense_Mutation_p.R116H|DST_uc003pdd.3_Missense_Mutation_p.R116H|DST_uc003pde.2_Missense_Mutation_p.R558H	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	442					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
PHF3	23469	broad.mit.edu	37	6	64422545	64422545	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:64422545C>T	uc003pep.1	+	15	5087	c.5061C>T	c.(5059-5061)AAC>AAT	p.N1687N	PHF3_uc003pen.2_Silent_p.N1599N|PHF3_uc011dxs.1_Silent_p.N956N	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1687					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)															---	---	---	---
EYS	346007	broad.mit.edu	37	6	66205020	66205020	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:66205020G>A	uc011dxu.1	-	4	822	c.284C>T	c.(283-285)TCT>TTT	p.S95F	EYS_uc003peq.2_Missense_Mutation_p.S95F|EYS_uc003per.1_Missense_Mutation_p.S95F|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	95					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75893741	75893741	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75893741C>T	uc003phs.2	-	9	1283	c.1117G>A	c.(1117-1119)GCA>ACA	p.A373T	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Missense_Mutation_p.A31T	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	373	Fibronectin type-III 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
MYO6	4646	broad.mit.edu	37	6	76540214	76540214	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76540214T>C	uc003pih.1	+	5	622	c.343T>C	c.(343-345)TAT>CAT	p.Y115H	MYO6_uc003pig.1_Missense_Mutation_p.Y115H|MYO6_uc003pii.1_Missense_Mutation_p.Y115H	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	115	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)														---	---	---	---
MYO6	4646	broad.mit.edu	37	6	76580408	76580408	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76580408T>C	uc003pih.1	+						MYO6_uc003pig.1_Intron|MYO6_uc003pii.1_Intron	NM_004999	NP_004990			myosin VI						actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)														---	---	---	---
IMPG1	3617	broad.mit.edu	37	6	76660365	76660365	+	Missense_Mutation	SNP	G	A	A	rs142123216		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76660365G>A	uc003pik.1	-	13	1868	c.1738C>T	c.(1738-1740)CGT>TGT	p.R580C		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	580	SEA 2.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)																---	---	---	---
TBX18	9096	broad.mit.edu	37	6	85446535	85446535	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:85446535C>T	uc003pkl.1	-	8	1692	c.1692G>A	c.(1690-1692)ACG>ACA	p.T564T	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	564					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)														---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90402760	90402760	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90402760A>T	uc003pnn.1	-	63	10105	c.9989T>A	c.(9988-9990)ATC>AAC	p.I3330N		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3330					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
FUT9	10690	broad.mit.edu	37	6	96651915	96651915	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:96651915C>A	uc003pop.3	+	3	1225	c.884C>A	c.(883-885)CCC>CAC	p.P295H		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	295	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)														---	---	---	---
KLHL32	114792	broad.mit.edu	37	6	97562222	97562222	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97562222G>A	uc010kcm.1	+	7	1663	c.1191G>A	c.(1189-1191)GAG>GAA	p.E397E	KLHL32_uc003poy.2_Silent_p.E397E|KLHL32_uc011ead.1_Silent_p.E361E|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Silent_p.E328E|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	397	Kelch 2.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)														---	---	---	---
POU3F2	5454	broad.mit.edu	37	6	99283635	99283635	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99283635G>A	uc003ppe.2	+	1	1056	c.886G>A	c.(886-888)GGC>AGC	p.G296S		NM_005604	NP_005595	P20265	PO3F2_HUMAN	POU domain, class 3, transcription factor 2	296	POU-specific.				positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)														---	---	---	---
BVES	11149	broad.mit.edu	37	6	105577343	105577343	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:105577343G>A	uc003pqw.2	-	3	419	c.262C>T	c.(262-264)CGA>TGA	p.R88*	BVES_uc003pqx.2_Nonsense_Mutation_p.R88*|BVES_uc003pqy.2_Nonsense_Mutation_p.R88*	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	88	Helical; (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)																---	---	---	---
ARMC2	84071	broad.mit.edu	37	6	109285402	109285402	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109285402G>A	uc003pss.3	+	16	2346	c.2172G>A	c.(2170-2172)GCG>GCA	p.A724A	ARMC2_uc011eao.1_Silent_p.A559A	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	724	ARM 11.						binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)														---	---	---	---
ZBTB24	9841	broad.mit.edu	37	6	109787338	109787338	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109787338T>C	uc003ptl.1	-	7	1978	c.1810A>G	c.(1810-1812)AAT>GAT	p.N604D	MICAL1_uc011eaq.1_5'Flank|ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.N548D|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	604					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)														---	---	---	---
AKD1	221264	broad.mit.edu	37	6	109815261	109815261	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109815261G>A	uc003ptn.2	-	40	5533	c.5456C>T	c.(5455-5457)GCG>GTG	p.A1819V	AKD1_uc011eas.1_Missense_Mutation_p.A204V	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1819					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1																		---	---	---	---
DSE	29940	broad.mit.edu	37	6	116747964	116747964	+	Missense_Mutation	SNP	C	T	T	rs112379267	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:116747964C>T	uc003pws.2	+	3	838	c.644C>T	c.(643-645)ACG>ATG	p.T215M	DSE_uc011ebf.1_Missense_Mutation_p.T215M|DSE_uc011ebg.1_Missense_Mutation_p.T234M|DSE_uc003pwt.2_Missense_Mutation_p.T215M	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	215					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)														---	---	---	---
RSPH4A	345895	broad.mit.edu	37	6	116938281	116938281	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:116938281C>T	uc003pxe.2	+	1	640	c.495C>T	c.(493-495)GAC>GAT	p.D165D	RSPH4A_uc010kee.2_Silent_p.D165D	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	165					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0														Kartagener_syndrome				---	---	---	---
NKAIN2	154215	broad.mit.edu	37	6	124979326	124979326	+	Intron	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:124979326T>A	uc003pzo.2	+						NKAIN2_uc003pzn.1_Intron|NKAIN2_uc003pzp.2_Intron|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Intron	NM_001040214	NP_001035304			T-cell lymphoma breakpoint-associated target 1							integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)														---	---	---	---
HEY2	23493	broad.mit.edu	37	6	126080953	126080953	+	3'UTR	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:126080953T>G	uc003qad.2	+	5					HEY2_uc011ebr.1_3'UTR	NM_012259	NP_036391			hairy/enhancer-of-split related with YRPW motif						negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)														---	---	---	---
NCOA7	135112	broad.mit.edu	37	6	126210800	126210800	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:126210800C>A	uc010kes.2	+	11	2049	c.1600C>A	c.(1600-1602)CCA>ACA	p.P534T	NCOA7_uc003qae.3_Missense_Mutation_p.P534T|NCOA7_uc003qah.2_Missense_Mutation_p.P523T|NCOA7_uc003qai.2_Missense_Mutation_p.P534T|NCOA7_uc010ket.2_Missense_Mutation_p.P419T	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	534					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)														---	---	---	---
TRMT11	60487	broad.mit.edu	37	6	126319758	126319758	+	Silent	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:126319758T>G	uc003qam.2	+	6	571	c.450T>G	c.(448-450)TCT>TCG	p.S150S	TRMT11_uc003qan.2_RNA|TRMT11_uc010kev.2_Silent_p.S150S	NM_001031712	NP_001026882	Q7Z4G4	TRM11_HUMAN	tRNA methyltransferase 11	150					tRNA processing		methyltransferase activity|nucleic acid binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0356)														---	---	---	---
C6orf174	387104	broad.mit.edu	37	6	127797085	127797085	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:127797085C>T	uc003qbd.2	-	6	2951	c.2086G>A	c.(2086-2088)GCC>ACC	p.A696T	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	696	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)														---	---	---	---
MOXD1	26002	broad.mit.edu	37	6	132645229	132645229	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:132645229T>C	uc003qdf.2	-	7	1053	c.954A>G	c.(952-954)ATA>ATG	p.I318M	MOXD1_uc003qde.2_Missense_Mutation_p.I250M	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	318	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)														---	---	---	---
BCLAF1	9774	broad.mit.edu	37	6	136582495	136582495	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136582495G>A	uc003qgx.1	-	12	2918	c.2665C>T	c.(2665-2667)CAT>TAT	p.H889Y	BCLAF1_uc011edb.1_Missense_Mutation_p.H168Y|BCLAF1_uc003qgw.1_Missense_Mutation_p.H716Y|BCLAF1_uc003qgy.1_Missense_Mutation_p.H838Y|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.H887Y	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	889					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)														---	---	---	---
SLC35D3	340146	broad.mit.edu	37	6	137243812	137243812	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:137243812G>A	uc003qhe.2	+	1	411	c.246G>A	c.(244-246)GCG>GCA	p.A82A		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	82	Helical; (Potential).				carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)														---	---	---	---
AIG1	51390	broad.mit.edu	37	6	143605337	143605337	+	Missense_Mutation	SNP	A	G	G	rs114392595	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143605337A>G	uc003qjh.2	+	4	530	c.490A>G	c.(490-492)ACC>GCC	p.T164A	AIG1_uc003qjf.2_Missense_Mutation_p.T154A|AIG1_uc003qji.2_Missense_Mutation_p.T102A	NM_016108	NP_057192	Q9NVV5	AIG1_HUMAN	androgen-induced 1	164						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(155;2.34e-05)|GBM - Glioblastoma multiforme(68;0.0246)														---	---	---	---
STX11	8676	broad.mit.edu	37	6	144508353	144508353	+	Missense_Mutation	SNP	G	A	A	rs141499372	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144508353G>A	uc003qks.3	+	2	781	c.589G>A	c.(589-591)GTG>ATG	p.V197M		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	197					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)										Familial_Hemophagocytic_Lymphohistiocytosis				---	---	---	---
STXBP5	134957	broad.mit.edu	37	6	147612300	147612300	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:147612300T>C	uc003qlz.2	+	9	1070	c.909T>C	c.(907-909)ACT>ACC	p.T303T	STXBP5_uc010khz.1_Silent_p.T303T|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_5'UTR	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	303	WD 6.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)														---	---	---	---
PLEKHG1	57480	broad.mit.edu	37	6	151130286	151130286	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151130286A>G	uc003qny.1	+	9	1270	c.958A>G	c.(958-960)AGC>GGC	p.S320G	PLEKHG1_uc011eel.1_Missense_Mutation_p.S360G|PLEKHG1_uc011eem.1_Missense_Mutation_p.S379G|PLEKHG1_uc003qnz.2_Missense_Mutation_p.S320G	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	320	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)														---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152570298	152570298	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152570298C>G	uc010kiw.2	-	105	20172	c.19570G>C	c.(19570-19572)GAG>CAG	p.E6524Q	SYNE1_uc010kiv.2_Missense_Mutation_p.E1048Q|SYNE1_uc003qos.3_Missense_Mutation_p.E1048Q|SYNE1_uc003qot.3_Missense_Mutation_p.E6453Q|SYNE1_uc003qou.3_Missense_Mutation_p.E6524Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6524	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152765568	152765568	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152765568T>G	uc010kiw.2	-	30	4417	c.3815A>C	c.(3814-3816)CAG>CCG	p.Q1272P	SYNE1_uc003qot.3_Missense_Mutation_p.Q1279P|SYNE1_uc003qou.3_Missense_Mutation_p.Q1272P|SYNE1_uc010kjb.1_Missense_Mutation_p.Q1255P|SYNE1_uc003qow.2_Missense_Mutation_p.Q567P|SYNE1_uc003qox.1_Missense_Mutation_p.Q788P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1272	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
PARK2	5071	broad.mit.edu	37	6	161969941	161969941	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161969941G>A	uc003qtx.3	-	9	1162	c.1028C>T	c.(1027-1029)CCG>CTG	p.P343L	PARK2_uc003qtv.3_Intron|PARK2_uc010kkd.2_Missense_Mutation_p.P152L|PARK2_uc003qtw.3_Missense_Mutation_p.P152L|PARK2_uc003qty.3_Missense_Mutation_p.P315L|PARK2_uc003qtz.3_Missense_Mutation_p.P194L|PARK2_uc010kke.1_Missense_Mutation_p.P362L|PARK2_uc011egf.1_Missense_Mutation_p.P17L	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	343	IBR-type.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)														---	---	---	---
PDE10A	10846	broad.mit.edu	37	6	165832261	165832261	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:165832261T>C	uc003qun.2	-	12	1071	c.830A>G	c.(829-831)TAT>TGT	p.Y277C	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.Y207C|PDE10A_uc003quo.2_Missense_Mutation_p.Y287C	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	277	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)													---	---	---	---
MICALL2	79778	broad.mit.edu	37	7	1480323	1480323	+	Intron	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1480323G>T	uc003skj.3	-						MICALL2_uc003skh.3_5'Flank|MICALL2_uc003ski.3_Intron	NM_182924	NP_891554			MICAL-like 2 isoform 1							cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)														---	---	---	---
MAD1L1	8379	broad.mit.edu	37	7	2255914	2255914	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2255914C>T	uc003slh.1	-	8	953	c.687G>A	c.(685-687)GAG>GAA	p.E229E	MAD1L1_uc003sle.1_5'Flank|MAD1L1_uc003slf.1_Silent_p.E229E|MAD1L1_uc003slg.1_Silent_p.E229E|MAD1L1_uc010ksh.1_Silent_p.E229E|MAD1L1_uc003sli.1_Silent_p.E137E|MAD1L1_uc010ksi.1_Silent_p.E182E|MAD1L1_uc010ksj.2_Silent_p.E229E	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	229	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4188999	4188999	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4188999G>A	uc003smx.2	+	30	4668	c.4529G>A	c.(4528-4530)CGG>CAG	p.R1510Q	SDK1_uc010kso.2_Missense_Mutation_p.R786Q|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1510	Fibronectin type-III 9.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4215451	4215451	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4215451A>C	uc003smx.2	+	34	5120	c.4981A>C	c.(4981-4983)ATG>CTG	p.M1661L	SDK1_uc010kso.2_Intron|SDK1_uc003smy.2_Missense_Mutation_p.M148L	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1661	Fibronectin type-III 10.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
KIAA0415	9907	broad.mit.edu	37	7	4823986	4823986	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4823986G>T	uc003sne.2	+	6	857	c.774G>T	c.(772-774)CCG>CCT	p.P258P	KIAA0415_uc010ksp.2_RNA	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	258					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)														---	---	---	---
RADIL	55698	broad.mit.edu	37	7	4917428	4917428	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4917428C>T	uc003snj.1	-	2	516	c.343G>A	c.(343-345)GTG>ATG	p.V115M	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	115	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)														---	---	---	---
FBXL18	80028	broad.mit.edu	37	7	5521395	5521395	+	3'UTR	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5521395G>A	uc003son.3	-	5						NM_024963	NP_079239			F-box and leucine-rich repeat protein 18											central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)														---	---	---	---
DAGLB	221955	broad.mit.edu	37	7	6456270	6456270	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6456270C>T	uc003sqa.2	-	11	1585	c.1415G>A	c.(1414-1416)CGG>CAG	p.R472Q	DAGLB_uc003spy.2_Missense_Mutation_p.R18Q|DAGLB_uc003spz.2_Missense_Mutation_p.R169Q|DAGLB_uc011jwt.1_Missense_Mutation_p.R286Q|DAGLB_uc011jwu.1_Missense_Mutation_p.R343Q|DAGLB_uc003sqb.2_Missense_Mutation_p.R191Q|DAGLB_uc003sqc.2_Missense_Mutation_p.R191Q|DAGLB_uc011jwv.1_Intron|DAGLB_uc003sqd.3_Missense_Mutation_p.R431Q|DAGLB_uc011jww.1_RNA	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	472	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity	p.R472R(1)		ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)														---	---	---	---
DAGLB	221955	broad.mit.edu	37	7	6465611	6465611	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6465611G>A	uc003sqa.2	-						DAGLB_uc011jwt.1_Intron|DAGLB_uc011jwu.1_Intron|DAGLB_uc003sqb.2_Intron|DAGLB_uc003sqc.2_Intron|DAGLB_uc011jwv.1_Intron|DAGLB_uc003sqd.3_Intron|DAGLB_uc011jww.1_Intron	NM_139179	NP_631918			diacylglycerol lipase, beta isoform 1						lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)														---	---	---	---
STK31	56164	broad.mit.edu	37	7	23826129	23826129	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:23826129C>A	uc003sws.3	+	19	2344	c.2277C>A	c.(2275-2277)GGC>GGA	p.G759G	STK31_uc003swt.3_Silent_p.G736G|STK31_uc011jze.1_Silent_p.G759G|STK31_uc010kuq.2_Silent_p.G736G|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	759	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9																		---	---	---	---
OSBPL3	26031	broad.mit.edu	37	7	24849497	24849497	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:24849497C>T	uc003sxf.2	-	20	2651	c.2246G>A	c.(2245-2247)CGG>CAG	p.R749Q	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.R713Q|OSBPL3_uc003sxh.2_Missense_Mutation_p.R718Q|OSBPL3_uc003sxi.2_Missense_Mutation_p.R682Q	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	749					lipid transport		lipid binding|protein binding			skin(1)	1																		---	---	---	---
NOD1	10392	broad.mit.edu	37	7	30496526	30496526	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30496526C>A	uc003tav.2	-	4	535	c.12G>T	c.(10-12)CAG>CAT	p.Q4H	NOD1_uc010kvs.2_Missense_Mutation_p.Q4H|NOD1_uc003tax.2_RNA|NOD1_uc003tay.2_RNA|NOD1_uc010kvt.2_RNA|NOD1_uc010kvu.2_RNA	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	4					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2																		---	---	---	---
HECW1	23072	broad.mit.edu	37	7	43503401	43503401	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:43503401A>G	uc003tid.1	+						HECW1_uc011kbi.1_Intron	NM_015052	NP_055867			NEDD4-like ubiquitin-protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23																		---	---	---	---
PGAM2	5224	broad.mit.edu	37	7	44105067	44105067	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44105067C>T	uc003tjs.2	-	1	97	c.62G>A	c.(61-63)CGT>CAT	p.R21H		NM_000290	NP_000281	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2	21					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity				0																		---	---	---	---
POLM	27434	broad.mit.edu	37	7	44112896	44112896	+	Silent	SNP	G	A	A	rs146318307	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44112896G>A	uc003tjt.2	-	11	1571	c.1479C>T	c.(1477-1479)AAC>AAT	p.N493N	POLM_uc003tjw.1_Missense_Mutation_p.T130M|POLM_uc003tju.2_Silent_p.N456N|POLM_uc003tjx.2_Missense_Mutation_p.T431M|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Missense_Mutation_p.T161M	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	493					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3													DNA_polymerases_(catalytic_subunits)					---	---	---	---
AEBP1	165	broad.mit.edu	37	7	44149841	44149841	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44149841G>A	uc003tkb.2	+	11	1601	c.1296G>A	c.(1294-1296)GCG>GCA	p.A432A	AEBP1_uc003tkc.3_5'Flank|AEBP1_uc003tkd.2_5'Flank	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	432	Required for DNA-binding and interaction with NFKBIA (By similarity).|F5/8 type C.|Interaction with MAPK1 and MAPK3 (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48349573	48349573	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48349573G>A	uc003toq.2	+	24	9376	c.9351G>A	c.(9349-9351)CTG>CTA	p.L3117L	ABCA13_uc010kys.1_Silent_p.L191L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3117					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
GBAS	2631	broad.mit.edu	37	7	56051483	56051483	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56051483G>A	uc003tre.1	+	6	515	c.507G>A	c.(505-507)CTG>CTA	p.L169L	GBAS_uc003trf.1_Silent_p.L130L	NM_001483	NP_001474	O75323	NIPS2_HUMAN	nipsnap homolog 2	169						integral to plasma membrane|membrane fraction|mitochondrion	protein binding			central_nervous_system(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)															---	---	---	---
ZNF107	51427	broad.mit.edu	37	7	64166846	64166846	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64166846C>T	uc003ttd.2	+	7	950	c.164C>T	c.(163-165)ACG>ATG	p.T55M	ZNF107_uc003tte.2_Missense_Mutation_p.T55M	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	55					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)																---	---	---	---
MLXIPL	51085	broad.mit.edu	37	7	73010239	73010239	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73010239G>A	uc003tyn.1	-	14	2167	c.2119C>T	c.(2119-2121)CGT>TGT	p.R707C	MLXIPL_uc003tyj.1_Missense_Mutation_p.R86C|MLXIPL_uc003tyk.1_Missense_Mutation_p.R686C|MLXIPL_uc003tyl.1_Missense_Mutation_p.R705C|MLXIPL_uc003tym.1_Missense_Mutation_p.R688C|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.R613C	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	707	Leucine-zipper.				anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)																---	---	---	---
HIP1	3092	broad.mit.edu	37	7	75176318	75176318	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:75176318G>A	uc003uds.1	-	25	2519	c.2478C>T	c.(2476-2478)TGC>TGT	p.C826C	HIP1_uc011kfz.1_Intron	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	826	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8								T	PDGFRB	CMML								---	---	---	---
STYXL1	51657	broad.mit.edu	37	7	75633122	75633122	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:75633122C>T	uc003uej.3	-	7	824	c.651G>A	c.(649-651)CCG>CCA	p.P217P	STYXL1_uc003uef.2_Silent_p.P23P|STYXL1_uc011kgf.1_Silent_p.P79P|STYXL1_uc011kgg.1_Silent_p.P69P|STYXL1_uc003ueh.2_Silent_p.P79P|STYXL1_uc003uek.3_Silent_p.P121P|STYXL1_uc003uel.2_Silent_p.P217P|STYXL1_uc003uem.2_Silent_p.P217P|STYXL1_uc010ldg.1_RNA|STYXL1_uc010ldh.1_Silent_p.P217P|STYXL1_uc003uen.1_Silent_p.P217P	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	217	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0																		---	---	---	---
CACNA2D1	781	broad.mit.edu	37	7	81591816	81591816	+	Intron	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81591816A>T	uc003uhr.1	-						CACNA2D1_uc011kgy.1_Intron	NM_000722	NP_000713			calcium channel, voltage-dependent, alpha							voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)													---	---	---	---
CACNA2D1	781	broad.mit.edu	37	7	81598254	81598254	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81598254C>G	uc003uhr.1	-	29	2600	c.2344G>C	c.(2344-2346)GTA>CTA	p.V782L	CACNA2D1_uc011kgy.1_Intron	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	794	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)													---	---	---	---
CACNA2D1	781	broad.mit.edu	37	7	81964453	81964453	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81964453C>T	uc003uhr.1	-	3	548	c.292G>A	c.(292-294)GTG>ATG	p.V98M		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	98	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)													---	---	---	---
PCLO	27445	broad.mit.edu	37	7	82785291	82785291	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82785291C>A	uc003uhx.2	-	2	955	c.666G>T	c.(664-666)CAG>CAT	p.Q222H	PCLO_uc003uhv.2_Missense_Mutation_p.Q222H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	222	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7																		---	---	---	---
SEMA3E	9723	broad.mit.edu	37	7	83119491	83119491	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:83119491A>G	uc003uhy.1	-	2	681	c.215T>C	c.(214-216)GTG>GCG	p.V72A		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	72	Sema.				axon guidance	extracellular space|membrane	receptor activity	p.V72L(1)		ovary(3)	3		Medulloblastoma(109;0.109)																---	---	---	---
GRM3	2913	broad.mit.edu	37	7	86468787	86468787	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86468787G>A	uc003uid.2	+	4	3056	c.1957G>A	c.(1957-1959)GCT>ACT	p.A653T	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.A525T|GRM3_uc010leh.2_Missense_Mutation_p.A245T	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	653	Helical; Name=3; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)													---	---	---	---
ABCB4	5244	broad.mit.edu	37	7	87092221	87092221	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87092221G>A	uc003uiv.1	-	4	215	c.139C>T	c.(139-141)CGA>TGA	p.R47*	ABCB4_uc003uiw.1_Nonsense_Mutation_p.R47*|ABCB4_uc003uix.1_Nonsense_Mutation_p.R47*|ABCB4_uc003uiy.2_Nonsense_Mutation_p.R47*	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	47	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)																	---	---	---	---
ADAM22	53616	broad.mit.edu	37	7	87762257	87762257	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87762257C>T	uc003ujn.2	+	12	1147	c.1068C>T	c.(1066-1068)GGC>GGT	p.G356G	ADAM22_uc003ujk.1_Silent_p.G356G|ADAM22_uc003ujl.1_Silent_p.G356G|ADAM22_uc003ujm.2_Silent_p.G356G|ADAM22_uc003ujo.2_Silent_p.G356G|ADAM22_uc003ujp.1_Silent_p.G408G	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	356	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
MGC26647	219557	broad.mit.edu	37	7	88423902	88423902	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:88423902T>G	uc003ujv.2	-	2	537	c.355A>C	c.(355-357)AAA>CAA	p.K119Q	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	119											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)															---	---	---	---
ZNF804B	219578	broad.mit.edu	37	7	88965252	88965252	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:88965252G>A	uc011khi.1	+	4	3494	c.2956G>A	c.(2956-2958)GCA>ACA	p.A986T		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	986						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)												HNSCC(36;0.09)			---	---	---	---
GTPBP10	85865	broad.mit.edu	37	7	89982118	89982118	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:89982118T>C	uc003ukm.1	+						GTPBP10_uc003uki.1_Intron|GTPBP10_uc003ukj.1_Intron|GTPBP10_uc003ukk.1_Intron|GTPBP10_uc003ukl.1_Intron|GTPBP10_uc003ukn.1_Intron|GTPBP10_uc003uko.1_Intron	NM_033107	NP_149098			GTP-binding protein 10 isoform 2						ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding				0																OREG0003797	type=REGULATORY REGION|Gene=BC021573|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
SAMD9	54809	broad.mit.edu	37	7	92732152	92732152	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92732152C>A	uc003umf.2	-	3	3515	c.3259G>T	c.(3259-3261)GCG>TCG	p.A1087S	SAMD9_uc003umg.2_Missense_Mutation_p.A1087S	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1087						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
CASD1	64921	broad.mit.edu	37	7	94167072	94167072	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94167072A>G	uc003uni.3	+	9	1359	c.1132A>G	c.(1132-1134)ATG>GTG	p.M378V	CASD1_uc003unh.2_3'UTR|CASD1_uc003unj.3_Missense_Mutation_p.M378V	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	378	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)															---	---	---	---
BAIAP2L1	55971	broad.mit.edu	37	7	97937118	97937118	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:97937118G>T	uc003upj.2	-	10	1309	c.1046C>A	c.(1045-1047)CCG>CAG	p.P349Q	uc003upk.1_5'Flank	NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	349	SH3.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98573796	98573796	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98573796G>A	uc003upp.2	+	53	8052	c.7843G>A	c.(7843-7845)GTT>ATT	p.V2615I	TRRAP_uc011kis.1_Missense_Mutation_p.V2597I|TRRAP_uc003upr.2_Missense_Mutation_p.V2314I	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2615					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
PTCD1	26024	broad.mit.edu	37	7	99056894	99056894	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99056894C>T	uc011kiw.1	-						ATP5J2_uc003uql.2_Intron|ATP5J2_uc003uqm.2_Intron|ATP5J2_uc003uqn.2_Intron|ATP5J2_uc003uqo.2_Intron	NM_015545	NP_056360			pentatricopeptide repeat domain 1											ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)													OREG0018190	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
AP4M1	9179	broad.mit.edu	37	7	99700543	99700543	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99700543G>A	uc003utb.3	+	4	519	c.311G>A	c.(310-312)CGC>CAC	p.R104H	MCM7_uc003usv.1_5'Flank|MCM7_uc003usw.1_5'Flank|MCM7_uc003usx.1_5'Flank|AP4M1_uc011kjg.1_Missense_Mutation_p.R104H|AP4M1_uc010lgl.1_Missense_Mutation_p.R104H|AP4M1_uc003utc.3_Missense_Mutation_p.R111H|AP4M1_uc010lgm.2_Intron|AP4M1_uc003utd.2_Missense_Mutation_p.R104H|AP4M1_uc011kjh.1_Missense_Mutation_p.R56H|AP4M1_uc003ute.3_5'UTR|AP4M1_uc003utf.3_5'UTR	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	104					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
SPDYE3	441272	broad.mit.edu	37	7	99913460	99913460	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99913460A>G	uc003uug.1	+	2	363	c.123A>G	c.(121-123)TCA>TCG	p.S41S		NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	418											0																		---	---	---	---
AGFG2	3268	broad.mit.edu	37	7	100160278	100160278	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100160278G>A	uc003uvf.2	+	8	1196	c.1060G>A	c.(1060-1062)GGC>AGC	p.G354S	AGFG2_uc010lgy.2_Silent_p.A215A	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	354					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
PCOLCE	5118	broad.mit.edu	37	7	100204175	100204175	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100204175C>T	uc003uvo.2	+	6	1060	c.862C>T	c.(862-864)CGG>TGG	p.R288W	uc011kjy.1_5'Flank|PCOLCE_uc010lhb.1_RNA|PCOLCE_uc003uvp.1_RNA	NM_002593	NP_002584	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	288		Cleavage.|Cleavage.			multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity				0	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)																	---	---	---	---
SLC12A9	56996	broad.mit.edu	37	7	100459447	100459447	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100459447G>A	uc003uwp.2	+	12	1767	c.1625G>A	c.(1624-1626)CGG>CAG	p.R542Q	SLC12A9_uc003uwq.2_Missense_Mutation_p.R453Q|SLC12A9_uc011kki.1_Missense_Mutation_p.R73Q|SLC12A9_uc003uwr.2_Missense_Mutation_p.R278Q|SLC12A9_uc003uws.2_Missense_Mutation_p.R73Q|SLC12A9_uc003uwt.2_Missense_Mutation_p.R278Q|SLC12A9_uc003uwv.2_Missense_Mutation_p.R73Q	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	542	Extracellular (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100685976	100685976	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100685976T>A	uc003uxp.1	+	3	11332	c.11279T>A	c.(11278-11280)GTC>GAC	p.V3760D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3760	Extracellular (Potential).|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
RABL5	64792	broad.mit.edu	37	7	100958511	100958511	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100958511A>G	uc003uyl.2	-	5	565	c.462T>C	c.(460-462)CCT>CCC	p.P154P	RABL5_uc011kkk.1_Silent_p.P77P|RABL5_uc011kkl.1_Silent_p.P77P|RABL5_uc003uym.2_Silent_p.P124P|RABL5_uc010lhw.2_RNA	NM_022777	NP_073614	Q9H7X7	RABL5_HUMAN	RAB, member RAS oncogene family-like 5 isoform	154							GTP binding				0	Lung NSC(181;0.215)															OREG0018221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ORC5L	5001	broad.mit.edu	37	7	103835622	103835622	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103835622C>T	uc003vcb.2	-	5	633	c.522G>A	c.(520-522)CCG>CCA	p.P174P	ORC5L_uc011klp.1_Silent_p.P42P|ORC5L_uc003vcc.2_Silent_p.P174P|ORC5L_uc003vcd.2_Silent_p.P174P	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1	174					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0																		---	---	---	---
MLL5	55904	broad.mit.edu	37	7	104731768	104731768	+	Intron	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:104731768T>G	uc003vcm.2	+						MLL5_uc003vcl.2_Missense_Mutation_p.W577G|MLL5_uc010ljc.2_Intron	NM_182931	NP_891847			myeloid/lymphoid or mixed-lineage leukemia 5						cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
DOCK4	9732	broad.mit.edu	37	7	111517184	111517184	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:111517184T>C	uc003vfx.2	-	17	1915	c.1646A>G	c.(1645-1647)AAG>AGG	p.K549R	DOCK4_uc003vfw.2_5'UTR|DOCK4_uc003vfy.2_Missense_Mutation_p.K549R|DOCK4_uc003vga.1_Missense_Mutation_p.K154R	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	549	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)																---	---	---	---
MDFIC	29969	broad.mit.edu	37	7	114563029	114563029	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:114563029C>T	uc003vhf.2	+	2	531	c.268C>T	c.(268-270)CGC>TGC	p.R90C	MDFIC_uc003vhg.2_RNA	NM_199072	NP_951038	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing protein	Error:Variant_position_missing_in_Q9P1T7_after_alignment					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleolus|nucleus	cyclin binding|Tat protein binding			ovary(1)	1																		---	---	---	---
KCND2	3751	broad.mit.edu	37	7	119915437	119915437	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:119915437G>T	uc003vjj.1	+	1	1716	c.751G>T	c.(751-753)GCG>TCG	p.A251S		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	251	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)																	---	---	---	---
PTPRZ1	5803	broad.mit.edu	37	7	121637988	121637988	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121637988G>T	uc003vjy.2	+	10	1563	c.1168G>T	c.(1168-1170)GCC>TCC	p.A390S	PTPRZ1_uc003vjz.2_Missense_Mutation_p.A390S	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	390	Extracellular (Potential).|Fibronectin type-III.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9																		---	---	---	---
SLC13A1	6561	broad.mit.edu	37	7	122809297	122809297	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122809297G>A	uc003vkm.2	-	4	483	c.458C>T	c.(457-459)GCT>GTT	p.A153V	SLC13A1_uc010lks.2_5'UTR	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	153						integral to membrane|plasma membrane	sodium:sulfate symporter activity	p.A153V(1)		ovary(2)	2					Succinic acid(DB00139)													---	---	---	---
GRM8	2918	broad.mit.edu	37	7	126173175	126173175	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:126173175C>T	uc003vlr.2	-	8	2572	c.2261G>A	c.(2260-2262)GGA>GAA	p.G754E	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.G754E|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	754	Helical; Name=5; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)										HNSCC(24;0.065)			---	---	---	---
IRF5	3663	broad.mit.edu	37	7	128582176	128582176	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128582176G>A	uc003vog.2	+	2	162	c.41G>A	c.(40-42)CGC>CAC	p.R14H	IRF5_uc010llr.1_Missense_Mutation_p.R14H|IRF5_uc011kot.1_Missense_Mutation_p.R14H|IRF5_uc011kou.1_Missense_Mutation_p.R14H|IRF5_uc010lls.1_Missense_Mutation_p.R14H|IRF5_uc003voh.2_Missense_Mutation_p.R14H|IRF5_uc010llt.2_Missense_Mutation_p.R14H|IRF5_uc003voi.2_Missense_Mutation_p.R14H|IRF5_uc010llu.1_Missense_Mutation_p.R14H|IRF5_uc003vok.2_Missense_Mutation_p.R14H|IRF5_uc003voj.3_Missense_Mutation_p.R14H|IRF5_uc010llv.1_Missense_Mutation_p.R14H|IRF5_uc010llw.1_Missense_Mutation_p.R14H	NM_002200	NP_002191	Q13568	IRF5_HUMAN	interferon regulatory factor 5 isoform a	14	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
SMO	6608	broad.mit.edu	37	7	128849174	128849174	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128849174A>G	uc003vor.2	+	8	1682	c.1402A>G	c.(1402-1404)AGC>GGC	p.S468G	SMO_uc003vos.2_Missense_Mutation_p.S143G	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	468	Helical; Name=6; (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37								Mis		skin basal cell 								---	---	---	---
UBE2H	7328	broad.mit.edu	37	7	129479104	129479104	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129479104C>T	uc003vpf.1	-	6	764	c.370G>A	c.(370-372)GGT>AGT	p.G124S	UBE2H_uc003vpg.1_Missense_Mutation_p.G93S	NM_003344	NP_003335	P62256	UBE2H_HUMAN	ubiquitin-conjugating enzyme E2H isoform 1	124					protein K11-linked ubiquitination|protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin-protein ligase activity			skin(1)	1	Melanoma(18;0.0435)																	---	---	---	---
TRIM24	8805	broad.mit.edu	37	7	138189060	138189060	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138189060C>T	uc003vuc.2	+	2	605	c.390C>T	c.(388-390)TGC>TGT	p.C130C	TRIM24_uc003vub.2_Silent_p.C130C	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	130					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8																		---	---	---	---
UBN2	254048	broad.mit.edu	37	7	138944044	138944044	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138944044T>C	uc011kqr.1	+	5	833	c.833T>C	c.(832-834)ATG>ACG	p.M278T	UBN2_uc003vuv.2_Missense_Mutation_p.M1T	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	278	Lys-rich.									ovary(1)|skin(1)	2																		---	---	---	---
HIPK2	28996	broad.mit.edu	37	7	139316026	139316026	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139316026C>A	uc003vvf.3	-	4	1406	c.1232G>T	c.(1231-1233)CGG>CTG	p.R411L	HIPK2_uc003vvd.3_Missense_Mutation_p.R411L	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	411	Protein kinase.|Interaction with DAXX.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)																	---	---	---	---
TBXAS1	6916	broad.mit.edu	37	7	139706977	139706977	+	Silent	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139706977T>G	uc011kqv.1	+	11	1526	c.1362T>G	c.(1360-1362)GCT>GCG	p.A454A	TBXAS1_uc003vvh.2_Silent_p.A408A|TBXAS1_uc010lne.2_Silent_p.A340A|TBXAS1_uc011kqu.1_Silent_p.A359A|TBXAS1_uc003vvi.2_Silent_p.A408A|TBXAS1_uc003vvj.2_Silent_p.A408A|TBXAS1_uc011kqw.1_Silent_p.A388A	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	407	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)																	---	---	---	---
JHDM1D	80853	broad.mit.edu	37	7	139791763	139791763	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139791763A>G	uc003vvm.2	-	19	2576	c.2572T>C	c.(2572-2574)TAT>CAT	p.Y858H	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	858					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)																	---	---	---	---
TRPV6	55503	broad.mit.edu	37	7	142571315	142571315	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142571315G>T	uc003wbx.1	-	13	1890	c.1674C>A	c.(1672-1674)ACC>ACA	p.T558T	TRPV6_uc003wbw.1_Silent_p.T344T|TRPV6_uc010lou.1_Silent_p.T429T	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	558	Helical; (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)																	---	---	---	---
KEL	3792	broad.mit.edu	37	7	142643391	142643391	+	Missense_Mutation	SNP	C	T	T	rs61729041		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142643391C>T	uc003wcb.2	-	11	1427	c.1217G>A	c.(1216-1218)CGA>CAA	p.R406Q		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	406	Extracellular (Potential).		R -> Q (in KEL26 antigen).		proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)																	---	---	---	---
EPHA1	2041	broad.mit.edu	37	7	143095949	143095949	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143095949G>A	uc003wcz.2	-	6	1168	c.1081C>T	c.(1081-1083)CGC>TGC	p.R361C		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	361	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)																---	---	---	---
CNTNAP2	26047	broad.mit.edu	37	7	146818164	146818164	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:146818164G>A	uc003weu.1	+	6	1364	c.848G>A	c.(847-849)CGC>CAC	p.R283H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	283	Laminin G-like 1.|Extracellular (Potential).		R -> C.		behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)												HNSCC(39;0.1)			---	---	---	---
EZH2	2146	broad.mit.edu	37	7	148507454	148507454	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148507454A>G	uc003wfd.1	-	17	2151	c.1985T>C	c.(1984-1986)ATG>ACG	p.M662T	EZH2_uc011kug.1_Missense_Mutation_p.M611T|EZH2_uc003wfb.1_Missense_Mutation_p.M667T|EZH2_uc003wfc.1_Missense_Mutation_p.M623T|EZH2_uc011kuh.1_Missense_Mutation_p.M653T	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	662	SET.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.V662fs*13(1)		haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)					Mis		DLBCL								---	---	---	---
ZNF746	155061	broad.mit.edu	37	7	149174108	149174108	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149174108G>A	uc003wfw.2	-	6	1014	c.743C>T	c.(742-744)CCG>CTG	p.P248L	ZNF746_uc010lpi.2_Missense_Mutation_p.P248L	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	248					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)															---	---	---	---
ZNF746	155061	broad.mit.edu	37	7	149191572	149191572	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149191572G>A	uc003wfw.2	-	2	318	c.47C>T	c.(46-48)GCC>GTC	p.A16V	ZNF746_uc010lpi.2_Missense_Mutation_p.A16V	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	16	Potential.				negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)															---	---	---	---
ZNF862	643641	broad.mit.edu	37	7	149547315	149547315	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149547315C>T	uc010lpn.2	+	5	1197	c.1005C>T	c.(1003-1005)TTC>TTT	p.F335F	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	335	KRAB 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1																		---	---	---	---
ZNF862	643641	broad.mit.edu	37	7	149557773	149557773	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149557773G>A	uc010lpn.2	+	7	1716	c.1524G>A	c.(1522-1524)ACG>ACA	p.T508T	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	508	TTF-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1																		---	---	---	---
LRRC61	65999	broad.mit.edu	37	7	150034580	150034580	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150034580C>T	uc003wgv.2	+	3	1304	c.630C>T	c.(628-630)AGC>AGT	p.S210S	LRRC61_uc003wgx.2_Silent_p.S210S|LRRC61_uc003wgw.2_Silent_p.S210S|LRRC61_uc003wgz.3_Silent_p.S210S	NM_023942	NP_076431	Q9BV99	LRC61_HUMAN	leucine rich repeat containing 61	210											0			OV - Ovarian serous cystadenocarcinoma(82;0.011)															---	---	---	---
KCNH2	3757	broad.mit.edu	37	7	150656686	150656686	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150656686C>G	uc003wic.2	-	3	459	c.446G>C	c.(445-447)GGC>GCC	p.G149A	KCNH2_uc011kux.1_Missense_Mutation_p.G53A|KCNH2_uc003wie.2_Missense_Mutation_p.G149A	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	149	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)													---	---	---	---
NUB1	51667	broad.mit.edu	37	7	151073716	151073716	+	Intron	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151073716C>G	uc003wjx.2	+						NUB1_uc003wjw.2_Intron|NUB1_uc010lqc.2_Intron	NM_016118	NP_057202			NEDD8 ultimate buster-1						positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)														---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151860314	151860314	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151860314G>A	uc003wla.2	-	43	10567	c.10348C>T	c.(10348-10350)CAG>TAG	p.Q3450*	MLL3_uc003wkz.2_Nonsense_Mutation_p.Q2511*|MLL3_uc003wky.2_Nonsense_Mutation_p.Q959*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3450	Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
DPP6	1804	broad.mit.edu	37	7	154684482	154684482	+	3'UTR	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154684482A>T	uc003wlk.2	+	26					DPP6_uc003wli.2_3'UTR|DPP6_uc003wlm.2_3'UTR|DPP6_uc011kvq.1_3'UTR	NM_130797	NP_570629			dipeptidyl-peptidase 6 isoform 1						cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)															---	---	---	---
SHH	6469	broad.mit.edu	37	7	155596424	155596424	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:155596424C>T	uc003wmk.1	-						SHH_uc003wmh.1_Intron|SHH_uc003wmi.1_Intron|SHH_uc003wmj.1_Intron	NM_000193	NP_000184			sonic hedgehog preproprotein						androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|lung(1)	4	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
ARHGEF10	9639	broad.mit.edu	37	8	1873491	1873491	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:1873491G>A	uc003wpr.2	+	22	2709	c.2531G>A	c.(2530-2532)GGG>GAG	p.G844E	ARHGEF10_uc003wpq.1_Missense_Mutation_p.G868E|ARHGEF10_uc003wps.2_Missense_Mutation_p.G806E|ARHGEF10_uc003wpv.2_Missense_Mutation_p.G576E|ARHGEF10_uc010lre.2_Missense_Mutation_p.G524E	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	869					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	3165998	3165998	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:3165998G>A	uc011kwk.1	-	24	4052	c.3662C>T	c.(3661-3663)CCG>CTG	p.P1221L	CSMD1_uc011kwj.1_Missense_Mutation_p.P613L|CSMD1_uc003wqe.2_Missense_Mutation_p.P377L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1221	Extracellular (Potential).|Sushi 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	3855550	3855550	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:3855550G>A	uc011kwk.1	-	5	1083	c.693C>T	c.(691-693)AAC>AAT	p.N231N		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	231	Extracellular (Potential).|CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
XKR5	389610	broad.mit.edu	37	8	6690370	6690370	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6690370C>T	uc003wqp.2	-	2	133	c.111G>A	c.(109-111)TGG>TGA	p.W37*	XKR5_uc003wqq.2_5'UTR|XKR5_uc003wqr.1_RNA	NM_207411	NP_997294	Q6UX68	XKR5_HUMAN	XK-related protein 5a	37	Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)														---	---	---	---
PINX1	54984	broad.mit.edu	37	8	10623273	10623273	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:10623273G>A	uc003wth.2	-	7	658	c.625C>T	c.(625-627)CGT>TGT	p.R209C	SOX7_uc011kwz.1_Intron|PINX1_uc003wti.2_3'UTR	NM_017884	NP_060354	Q96BK5	PINX1_HUMAN	PIN2-interacting protein 1	209					mitotic metaphase plate congression|negative regulation of cell proliferation	chromosome, telomeric region|condensed chromosome kinetochore|mitochondrion|nuclear chromosome|nucleolus|spindle	protein binding|telomerase inhibitor activity|telomeric RNA binding			lung(1)|kidney(1)|skin(1)	3				Kidney(29;0.0595)|COAD - Colon adenocarcinoma(149;0.105)|KIRC - Kidney renal clear cell carcinoma(542;0.201)														---	---	---	---
DLC1	10395	broad.mit.edu	37	8	12952587	12952587	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12952587G>A	uc003wwm.2	-						DLC1_uc003wwk.1_Intron|DLC1_uc003wwl.1_Intron|DLC1_uc011kxx.1_Intron	NM_182643	NP_872584			deleted in liver cancer 1 isoform 1						actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7																		---	---	---	---
DLC1	10395	broad.mit.edu	37	8	13357188	13357188	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:13357188T>C	uc003wwm.2	-	2	837	c.393A>G	c.(391-393)CAA>CAG	p.Q131Q	DLC1_uc003wwn.2_Silent_p.Q131Q|DLC1_uc011kxy.1_Silent_p.Q131Q	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	131					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7																		---	---	---	---
MSR1	4481	broad.mit.edu	37	8	16021619	16021619	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:16021619C>A	uc003wwz.2	-	5	970	c.772G>T	c.(772-774)GAT>TAT	p.D258Y	MSR1_uc010lsu.2_Missense_Mutation_p.D276Y|MSR1_uc003wxa.2_Missense_Mutation_p.D258Y|MSR1_uc003wxb.2_Missense_Mutation_p.D258Y|MSR1_uc011kxz.1_Missense_Mutation_p.D32Y	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	258	Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)														---	---	---	---
ZDHHC2	51201	broad.mit.edu	37	8	17055134	17055134	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17055134C>A	uc003wxe.2	+	5	814	c.417C>A	c.(415-417)CGC>CGA	p.R139R		NM_016353	NP_057437	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2	139	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding				0				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)														---	---	---	---
FGL1	2267	broad.mit.edu	37	8	17732005	17732005	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17732005C>T	uc003wxx.2	-	5	594	c.270G>A	c.(268-270)GGG>GGA	p.G90G	FGL1_uc003wxy.2_Silent_p.G90G|FGL1_uc003wxz.2_Silent_p.G90G|FGL1_uc003wya.2_Silent_p.G90G|FGL1_uc003wyb.2_Silent_p.G90G|FGL1_uc003wyc.2_Silent_p.G90G|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Silent_p.G140G|FGL1_uc003wyf.2_Silent_p.G60G	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	90	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)														---	---	---	---
PCM1	5108	broad.mit.edu	37	8	17867107	17867107	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17867107C>T	uc003wyi.3	+	31	5436	c.5014C>T	c.(5014-5016)CTT>TTT	p.L1672F	PCM1_uc011kyh.1_Missense_Mutation_p.L1664F|PCM1_uc003wyj.3_Missense_Mutation_p.L1618F|PCM1_uc011kyi.1_Missense_Mutation_p.L471F|PCM1_uc011kyj.1_Missense_Mutation_p.L428F|PCM1_uc003wyk.3_Missense_Mutation_p.L354F|PCM1_uc011kyk.1_Missense_Mutation_p.L288F	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	1672	Interaction with HAP1.				centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)				T	RET|JAK2	papillary thyroid|CML|MPD								---	---	---	---
SH2D4A	63898	broad.mit.edu	37	8	19250969	19250969	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:19250969G>T	uc003wzb.2	+	9	1525	c.1189G>T	c.(1189-1191)GAT>TAT	p.D397Y	SH2D4A_uc011kym.1_Missense_Mutation_p.D352Y|SH2D4A_uc003wzc.2_Missense_Mutation_p.D397Y	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	397	SH2.					cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)														---	---	---	---
LZTS1	11178	broad.mit.edu	37	8	20107710	20107710	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:20107710G>A	uc003wzr.2	-	3	1425	c.1314C>T	c.(1312-1314)GGC>GGT	p.G438G	LZTS1_uc010ltg.1_Silent_p.G438G	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	438					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)														---	---	---	---
FGF17	8822	broad.mit.edu	37	8	21903622	21903622	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21903622A>G	uc003xag.2	+						FGF17_uc003xah.2_Intron|FGF17_uc003xai.2_Missense_Mutation_p.K47E	NM_003867	NP_003858			fibroblast growth factor 17 precursor						cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|nervous system development	extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)														---	---	---	---
FAM160B2	64760	broad.mit.edu	37	8	21959298	21959298	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21959298G>A	uc011kyx.1	+	14	1838	c.1787G>A	c.(1786-1788)CGA>CAA	p.R596Q	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	596											0																		---	---	---	---
LGI3	203190	broad.mit.edu	37	8	22005798	22005798	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22005798G>A	uc003xav.2	-	8	1811	c.1522C>T	c.(1522-1524)CTG>TTG	p.L508L	LGI3_uc010ltu.2_Silent_p.L484L	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	508	EAR 7.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)														---	---	---	---
C8orf58	541565	broad.mit.edu	37	8	22459291	22459291	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22459291C>A	uc003xce.2	+	3	695	c.583C>A	c.(583-585)CTG>ATG	p.L195M	C8orf58_uc011kzl.1_Missense_Mutation_p.L195M|C8orf58_uc003xcf.2_Missense_Mutation_p.L195M|KIAA1967_uc003xch.2_5'Flank	NM_001013842	NP_001013864	Q8NAV2	CH058_HUMAN	hypothetical protein LOC541565	195										skin(1)	1		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)														---	---	---	---
KIAA1967	57805	broad.mit.edu	37	8	22464797	22464797	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22464797T>C	uc003xch.2	+	6	583	c.446T>C	c.(445-447)ATC>ACC	p.I149T	KIAA1967_uc003xci.2_Missense_Mutation_p.I149T|KIAA1967_uc003xcj.1_5'UTR	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	149					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)														---	---	---	---
KIAA1967	57805	broad.mit.edu	37	8	22476226	22476226	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22476226G>A	uc003xch.2	+	18	2454	c.2317G>A	c.(2317-2319)GAG>AAG	p.E773K	KIAA1967_uc003xci.2_Missense_Mutation_p.E773K|KIAA1967_uc003xcj.1_Missense_Mutation_p.E442K	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	773					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)														---	---	---	---
NEFL	4747	broad.mit.edu	37	8	24813259	24813259	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:24813259C>T	uc003xee.2	-	1	873	c.771G>A	c.(769-771)GCG>GCA	p.A257A		NM_006158	NP_006149	P07196	NFL_HUMAN	neurofilament, light polypeptide 68kDa	257	Rod.|Coil 2A.				anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)														---	---	---	---
KCTD9	54793	broad.mit.edu	37	8	25290099	25290099	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25290099A>G	uc003xeo.2	-	11	1132	c.974T>C	c.(973-975)CTG>CCG	p.L325P	PPP2R2A_uc003xek.2_Intron|KCTD9_uc011lad.1_RNA	NM_017634	NP_060104	Q7L273	KCTD9_HUMAN	potassium channel tetramerisation domain	325	Pentapeptide repeat 2.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)														---	---	---	---
DPYSL2	1808	broad.mit.edu	37	8	26510813	26510813	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:26510813G>A	uc003xfb.1	+	13	1877	c.1527G>A	c.(1525-1527)ACG>ACA	p.T509T	DPYSL2_uc003xfa.2_Silent_p.T614T|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Silent_p.T473T	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	509				T->A: Greatly diminishes binding to 3F4 antibody.	axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)														---	---	---	---
ZNF395	55893	broad.mit.edu	37	8	28206306	28206306	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28206306C>T	uc003xgq.2	-	10	1560	c.1472G>A	c.(1471-1473)GGC>GAC	p.G491D	ZNF395_uc003xgt.2_Missense_Mutation_p.G491D|ZNF395_uc003xgr.2_Missense_Mutation_p.G491D|ZNF395_uc003xgs.2_Missense_Mutation_p.G491D	NM_018660	NP_061130	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	491					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)														---	---	---	---
UNC5D	137970	broad.mit.edu	37	8	35406866	35406866	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:35406866C>T	uc003xjr.1	+	2	488	c.160C>T	c.(160-162)CCT>TCT	p.P54S	UNC5D_uc003xjs.1_Missense_Mutation_p.P49S	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	54	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)														---	---	---	---
FGFR1	2260	broad.mit.edu	37	8	38275768	38275768	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38275768G>A	uc003xlp.2	-	11	2350	c.1408C>T	c.(1408-1410)CGC>TGC	p.R470C	FGFR1_uc010lwf.2_RNA|FGFR1_uc011lbo.1_Missense_Mutation_p.R468C|FGFR1_uc011lbp.1_Missense_Mutation_p.R381C|FGFR1_uc011lbq.1_Missense_Mutation_p.R379C|FGFR1_uc010lwk.2_Missense_Mutation_p.R460C	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	470	Cytoplasmic (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						---	---	---	---
FGFR1	2260	broad.mit.edu	37	8	38279341	38279341	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38279341T>C	uc003xlp.2	-	8	1997	c.1055A>G	c.(1054-1056)CAC>CGC	p.H352R	FGFR1_uc011lbo.1_Missense_Mutation_p.H350R|FGFR1_uc011lbp.1_Missense_Mutation_p.H263R|FGFR1_uc011lbq.1_Missense_Mutation_p.H261R|FGFR1_uc010lwk.2_Missense_Mutation_p.H344R|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_Missense_Mutation_p.H192R|FGFR1_uc011lbt.1_Intron|FGFR1_uc011lbu.1_Missense_Mutation_p.H383R|FGFR1_uc011lbv.1_Missense_Mutation_p.H350R|FGFR1_uc011lbw.1_Missense_Mutation_p.H263R|FGFR1_uc011lbx.1_Missense_Mutation_p.H263R	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	352	Ig-like C2-type 3.|Extracellular (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						---	---	---	---
TACC1	6867	broad.mit.edu	37	8	38705511	38705511	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38705511G>T	uc010lwp.2	+	13	2767	c.2388G>T	c.(2386-2388)GAG>GAT	p.E796D	TACC1_uc003xma.2_Missense_Mutation_p.E234D|TACC1_uc003xlz.2_Missense_Mutation_p.E601D|TACC1_uc003xmc.3_Missense_Mutation_p.E600D|TACC1_uc011lbz.1_Missense_Mutation_p.E783D|TACC1_uc003xmb.3_Missense_Mutation_p.E722D|TACC1_uc003xmf.3_Missense_Mutation_p.E386D|TACC1_uc011lca.1_Missense_Mutation_p.E779D|TACC1_uc011lcb.1_Missense_Mutation_p.E572D|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Missense_Mutation_p.E613D|TACC1_uc010lwq.2_Missense_Mutation_p.E612D	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	796	|Interaction with CH-TOG.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)															---	---	---	---
IDO2	169355	broad.mit.edu	37	8	39845406	39845406	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39845406A>G	uc010lwy.1	+	7	747	c.505A>G	c.(505-507)ATC>GTC	p.I169V	IDO2_uc003xno.1_RNA|IDO2_uc010lwz.1_Intron|IDO2_uc003xnp.1_5'UTR	NM_194294	NP_919270	Q6ZQW0	I23O2_HUMAN	indoleamine-pyrrole 2,3 dioxygenase-like 1	156					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			ovary(2)	2																		---	---	---	---
ANK1	286	broad.mit.edu	37	8	41526075	41526075	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41526075C>T	uc003xok.2	-	39	5188	c.5104G>A	c.(5104-5106)GAC>AAC	p.D1702N	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.D856N|ANK1_uc003xoi.2_Missense_Mutation_p.D1702N|ANK1_uc003xoj.2_Missense_Mutation_p.D1702N|ANK1_uc003xol.2_Missense_Mutation_p.D1540N|ANK1_uc003xom.2_Missense_Mutation_p.D1743N	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1702	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)															---	---	---	---
ANK1	286	broad.mit.edu	37	8	41753904	41753904	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41753904C>T	uc003xom.2	-	1	377	c.95G>A	c.(94-96)CGG>CAG	p.R32Q		NM_001142446	NP_001135918	P16157	ANK1_HUMAN	ankyrin 1 isoform 9	Error:Variant_position_missing_in_P16157_after_alignment					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)															---	---	---	---
CHRNB3	1142	broad.mit.edu	37	8	42587519	42587519	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42587519T>C	uc003xpi.1	+	5	1197	c.1069T>C	c.(1069-1071)TCA>CCA	p.S357P		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	357	Cytoplasmic (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)															---	---	---	---
FNTA	2339	broad.mit.edu	37	8	42940306	42940306	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42940306T>C	uc003xps.2	+	9	1069	c.1021T>C	c.(1021-1023)TGT>CGT	p.C341R	FNTA_uc003xpt.2_Missense_Mutation_p.C250R|FNTA_uc003xpu.2_Missense_Mutation_p.C274R|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	341					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)															---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48845642	48845642	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48845642C>T	uc003xqi.2	-	16	1771	c.1714G>A	c.(1714-1716)GTT>ATT	p.V572I	PRKDC_uc003xqj.2_Missense_Mutation_p.V572I|PRKDC_uc011ldh.1_Missense_Mutation_p.V572I	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	572					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48852128	48852128	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48852128A>G	uc003xqi.2	-	11	1153	c.1096T>C	c.(1096-1098)TAT>CAT	p.Y366H	PRKDC_uc003xqj.2_Missense_Mutation_p.Y366H|PRKDC_uc011ldh.1_Missense_Mutation_p.Y366H	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	366					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
RB1CC1	9821	broad.mit.edu	37	8	53540632	53540632	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53540632T>C	uc003xre.3	-	22	5154	c.4596A>G	c.(4594-4596)TCA>TCG	p.S1532S	RB1CC1_uc003xrf.3_Silent_p.S1532S	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	1532					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)																---	---	---	---
RB1CC1	9821	broad.mit.edu	37	8	53573539	53573539	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53573539T>G	uc003xre.3	-	11	2132	c.1574A>C	c.(1573-1575)AAG>ACG	p.K525T	RB1CC1_uc003xrf.3_Missense_Mutation_p.K525T	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	525					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)																---	---	---	---
NPBWR1	2831	broad.mit.edu	37	8	53853024	53853024	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53853024G>A	uc011ldu.1	+	1	557	c.557G>A	c.(556-558)CGC>CAC	p.R186H		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	186	Extracellular (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)																---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61654300	61654300	+	Silent	SNP	G	A	A	rs115293759	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61654300G>A	uc003xue.2	+	2	786	c.309G>A	c.(307-309)TCG>TCA	p.S103S		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	103					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61654770	61654770	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61654770C>T	uc003xue.2	+	2	1256	c.779C>T	c.(778-780)CCC>CTC	p.P260L		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	260					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61764728	61764728	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61764728G>A	uc003xue.2	+	29	6293	c.5816G>A	c.(5815-5817)CGG>CAG	p.R1939Q		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1939	Poly-Arg.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
MTFR1	9650	broad.mit.edu	37	8	66619497	66619497	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:66619497G>A	uc003xvm.2	+						MTFR1_uc011lep.1_Intron|MTFR1_uc003xvn.2_Intron|MTFR1_uc003xvo.1_Intron	NM_014637	NP_055452			mitochondrial fission regulator 1 isoform 1							mitochondrion|plasma membrane				pancreas(1)	1			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)															---	---	---	---
C8orf45	157777	broad.mit.edu	37	8	67793093	67793093	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67793093T>C	uc003xwz.3	+	8	890	c.719T>C	c.(718-720)GTG>GCG	p.V240A	C8orf45_uc003xwv.2_Missense_Mutation_p.V240A|C8orf45_uc011lev.1_Missense_Mutation_p.V240A|C8orf45_uc011lew.1_Missense_Mutation_p.V171A|C8orf45_uc011lex.1_5'UTR|C8orf45_uc003xwy.3_Missense_Mutation_p.V240A	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	240					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
COPS5	10987	broad.mit.edu	37	8	67963489	67963489	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67963489C>T	uc003xxe.2	-	6	1078	c.747G>A	c.(745-747)ACG>ACA	p.T249T	COPS5_uc003xxd.2_Silent_p.T185T|COPS5_uc003xxf.2_Silent_p.T294T|COPS5_uc010lyu.1_RNA|COPS5_uc010lyv.1_Silent_p.T249T	NM_006837	NP_006828	Q92905	CSN5_HUMAN	COP9 signalosome subunit 5	249					cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)															---	---	---	---
SLCO5A1	81796	broad.mit.edu	37	8	70744651	70744651	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:70744651C>T	uc003xyl.2	-	2	965	c.258G>A	c.(256-258)CCG>CCA	p.P86P	SLCO5A1_uc010lzb.2_Silent_p.P86P|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.P86P|SLCO5A1_uc010lzc.2_Silent_p.P86P	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	86	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)													OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TMEM70	54968	broad.mit.edu	37	8	74893786	74893786	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:74893786A>G	uc003yab.2	+	3	800	c.713A>G	c.(712-714)TAT>TGT	p.Y238C	TMEM70_uc003yac.2_3'UTR	NM_017866	NP_060336	Q9BUB7	TMM70_HUMAN	transmembrane protein 70 isoform a	238					mitochondrial proton-transporting ATP synthase complex assembly	integral to mitochondrial membrane|mitochondrial inner membrane				ovary(1)	1	Breast(64;0.0311)		Epithelial(68;0.0186)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0564)															---	---	---	---
JPH1	56704	broad.mit.edu	37	8	75227418	75227418	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75227418C>T	uc003yae.2	-	2	857	c.817G>A	c.(817-819)GTG>ATG	p.V273M	JPH1_uc003yaf.2_Missense_Mutation_p.V273M|JPH1_uc003yag.1_Missense_Mutation_p.V137M	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	273	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)															---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77776241	77776241	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77776241C>T	uc003yav.2	+	11	10543	c.10156C>T	c.(10156-10158)CCT>TCT	p.P3386S		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3382						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
FABP5	2171	broad.mit.edu	37	8	82196753	82196753	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:82196753G>A	uc003yca.1	+	4	407	c.359G>A	c.(358-360)TGT>TAT	p.C120Y		NM_001444	NP_001435	Q01469	FABP5_HUMAN	fatty acid binding protein 5	120					epidermis development	cytoplasm	fatty acid binding|protein binding|transporter activity				0	Lung NSC(7;3.57e-05)|all_lung(9;0.00011)		Epithelial(68;0.102)															---	---	---	---
CA3	761	broad.mit.edu	37	8	86358463	86358463	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:86358463G>A	uc003ydj.2	+	6	683	c.600G>A	c.(598-600)CCG>CCA	p.P200P	CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	200					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0																		---	---	---	---
DECR1	1666	broad.mit.edu	37	8	91029549	91029549	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:91029549C>A	uc003yek.1	+	2	408	c.267C>A	c.(265-267)GCC>GCA	p.A89A	DECR1_uc011lgc.1_Silent_p.A80A|DECR1_uc011lgd.1_Intron	NM_001359	NP_001350	Q16698	DECR_HUMAN	2,4-dienoyl CoA reductase 1 precursor	89	NADP.				fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH				0			BRCA - Breast invasive adenocarcinoma(11;0.00953)															---	---	---	---
RBM12B	389677	broad.mit.edu	37	8	94747516	94747516	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:94747516A>C	uc003yfz.2	-	3	1316	c.1123T>G	c.(1123-1125)TCA>GCA	p.S375A		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	375							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)															---	---	---	---
CDH17	1015	broad.mit.edu	37	8	95174358	95174358	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95174358C>T	uc003ygh.2	-	11	1440	c.1315G>A	c.(1315-1317)GTT>ATT	p.V439I	CDH17_uc011lgo.1_Missense_Mutation_p.V225I|CDH17_uc011lgp.1_Missense_Mutation_p.V439I	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	439	Extracellular (Potential).|Cadherin 4.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)															---	---	---	---
GEM	2669	broad.mit.edu	37	8	95272654	95272654	+	Silent	SNP	A	G	G	rs151310883	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95272654A>G	uc003ygj.2	-	2	327	c.78T>C	c.(76-78)GCT>GCC	p.A26A	GEM_uc003ygi.2_Silent_p.A26A	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	26					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100148882	100148882	+	Intron	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100148882T>G	uc003yiv.2	+						VPS13B_uc003yiw.2_Intron|VPS13B_uc003yit.2_Intron|VPS13B_uc003yiu.1_Intron|VPS13B_uc003yix.1_5'Flank	NM_017890	NP_060360			vacuolar protein sorting 13B isoform 5						protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100519362	100519362	+	Intron	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100519362C>G	uc003yiv.2	+						VPS13B_uc003yiw.2_Intron|VPS13B_uc003yiu.1_Intron|VPS13B_uc003yix.1_Intron	NM_017890	NP_060360			vacuolar protein sorting 13B isoform 5						protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100836166	100836166	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100836166A>G	uc003yiv.2	+	51	9476	c.9365A>G	c.(9364-9366)AAA>AGA	p.K3122R	VPS13B_uc003yiw.2_Missense_Mutation_p.K3097R	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3122					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
SPAG1	6674	broad.mit.edu	37	8	101232551	101232551	+	Missense_Mutation	SNP	G	A	A	rs150325048		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:101232551G>A	uc003yjh.1	+	13	1666	c.1580G>A	c.(1579-1581)CGG>CAG	p.R527Q	SPAG1_uc003yji.1_Missense_Mutation_p.R527Q	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	527	TPR 6.				single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)														---	---	---	---
GRHL2	79977	broad.mit.edu	37	8	102571012	102571012	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:102571012G>A	uc010mbu.2	+	4	980	c.650G>A	c.(649-651)AGC>AAC	p.S217N	GRHL2_uc011lhi.1_Missense_Mutation_p.S217N	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	217						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)															---	---	---	---
FZD6	8323	broad.mit.edu	37	8	104312361	104312361	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104312361C>T	uc003ylh.2	+	2	310	c.26C>T	c.(25-27)ACG>ATG	p.T9M	FZD6_uc003yli.2_Missense_Mutation_p.T9M|FZD6_uc003ylj.2_Missense_Mutation_p.T9M|FZD6_uc011lhn.1_Intron|FZD6_uc011lho.1_Translation_Start_Site|FZD6_uc011lhp.1_Translation_Start_Site	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	9					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)															---	---	---	---
RIMS2	9699	broad.mit.edu	37	8	105105763	105105763	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105105763A>G	uc003yls.2	+	21	3027	c.2786A>G	c.(2785-2787)GAT>GGT	p.D929G	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.D1002G|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)												HNSCC(12;0.0054)			---	---	---	---
EBAG9	9166	broad.mit.edu	37	8	110576795	110576795	+	3'UTR	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110576795T>C	uc003ynf.2	+	7					EBAG9_uc003yng.2_3'UTR	NM_198120	NP_936056			estrogen receptor binding site associated						apoptosis|regulation of cell growth	focal adhesion|Golgi membrane|integral to membrane|soluble fraction	apoptotic protease activator activity				0			OV - Ovarian serous cystadenocarcinoma(57;1.39e-14)															---	---	---	---
EIF3H	8667	broad.mit.edu	37	8	117671196	117671196	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117671196G>A	uc003yoa.2	-	3	339	c.313C>T	c.(313-315)CGG>TGG	p.R105W	EIF3H_uc003yob.2_Missense_Mutation_p.R119W|EIF3H_uc011lhz.1_Missense_Mutation_p.R105W	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	105	MPN.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)																	---	---	---	---
SAMD12	401474	broad.mit.edu	37	8	119391937	119391937	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:119391937G>A	uc003yom.2	-	4	454	c.325C>T	c.(325-327)CGA>TGA	p.R109*	SAMD12_uc010mda.1_Nonsense_Mutation_p.R109*|SAMD12_uc010mdb.1_RNA	NM_207506	NP_997389	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12 isoform	109	SAM.									ovary(1)	1	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)															---	---	---	---
ANXA13	312	broad.mit.edu	37	8	124714949	124714949	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124714949A>G	uc003yqu.2	-	3	192	c.119T>C	c.(118-120)ATC>ACC	p.I40T	ANXA13_uc003yqt.2_Missense_Mutation_p.I81T	NM_004306	NP_004297	P27216	ANX13_HUMAN	annexin A13 isoform a	40	Annexin 1.				cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
ADCY8	114	broad.mit.edu	37	8	131861974	131861974	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:131861974C>A	uc003ytd.3	-	10	2542	c.2286G>T	c.(2284-2286)GAG>GAT	p.E762D	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	762					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)												HNSCC(32;0.087)			---	---	---	---
EFR3A	23167	broad.mit.edu	37	8	132989340	132989340	+	Splice_Site	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:132989340G>T	uc003yte.2	+	12	1527	c.1326_splice	c.e12+1	p.M442_splice		NM_015137	NP_055952			EFR3 homolog A							plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)															---	---	---	---
KCNQ3	3786	broad.mit.edu	37	8	133141583	133141583	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133141583C>T	uc003ytj.2	-	15	2770	c.2545G>A	c.(2545-2547)GGC>AGC	p.G849S	KCNQ3_uc010mdt.2_Missense_Mutation_p.G837S|uc003yti.2_5'Flank	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	849					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)															---	---	---	---
TG	7038	broad.mit.edu	37	8	133919026	133919026	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133919026A>G	uc003ytw.2	+	17	3769	c.3728A>G	c.(3727-3729)CAG>CGG	p.Q1243R	TG_uc010mdw.2_Missense_Mutation_p.Q2R	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1243					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
TG	7038	broad.mit.edu	37	8	134144191	134144191	+	Splice_Site	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:134144191G>T	uc003ytw.2	+	46	8038	c.7997_splice	c.e46+1	p.G2666_splice	TG_uc010mdw.2_Splice_Site_p.G1425_splice|TG_uc011ljb.1_Splice_Site_p.G1035_splice|TG_uc011ljc.1_Splice_Site_p.G799_splice	NM_003235	NP_003226			thyroglobulin precursor						hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
WISP1	8840	broad.mit.edu	37	8	134232898	134232898	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:134232898T>C	uc003yub.2	+	3	500	c.424T>C	c.(424-426)TAC>CAC	p.Y142H	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	142	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)															---	---	---	---
WISP1	8840	broad.mit.edu	37	8	134233083	134233083	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:134233083C>T	uc003yub.2	+	3	685	c.609C>T	c.(607-609)TTC>TTT	p.F203F	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	203					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)															---	---	---	---
FAM135B	51059	broad.mit.edu	37	8	139190804	139190804	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139190804G>T	uc003yuy.2	-	10	1174	c.1003C>A	c.(1003-1005)CTC>ATC	p.L335I	FAM135B_uc003yux.2_Missense_Mutation_p.L236I|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	335										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)												HNSCC(54;0.14)			---	---	---	---
TRAPPC9	83696	broad.mit.edu	37	8	141321391	141321391	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141321391G>A	uc003yvj.2	-	10	1712	c.1578C>T	c.(1576-1578)GGC>GGT	p.G526G	TRAPPC9_uc003yvh.2_Silent_p.G624G|TRAPPC9_uc003yvi.1_Silent_p.G517G	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	526					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2																		---	---	---	---
BAI1	575	broad.mit.edu	37	8	143602199	143602199	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143602199G>A	uc003ywm.2	+	19	3120	c.2937G>A	c.(2935-2937)GAG>GAA	p.E979E		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	979	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
LY6D	8581	broad.mit.edu	37	8	143867013	143867013	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143867013G>A	uc003yxf.1	-	2	219	c.143C>T	c.(142-144)ACG>ATG	p.T48M		NM_003695	NP_003686	Q14210	LY6D_HUMAN	lymphocyte antigen 6 complex, locus D precursor	48	UPAR/Ly6.				cell adhesion	anchored to membrane|membrane fraction|plasma membrane	protein binding				0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
MAPK15	225689	broad.mit.edu	37	8	144803816	144803816	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144803816G>T	uc003yzj.2	+	12	1343	c.1302G>T	c.(1300-1302)AAG>AAT	p.K434N		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	434					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)															---	---	---	---
FAM83H	286077	broad.mit.edu	37	8	144811445	144811445	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144811445C>T	uc003yzk.2	-	3	565	c.496G>A	c.(496-498)GAA>AAA	p.E166K	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	166					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)															---	---	---	---
NRBP2	340371	broad.mit.edu	37	8	144921062	144921062	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144921062G>A	uc011lkt.1	-	9	877	c.737C>T	c.(736-738)GCG>GTG	p.A246V	NRBP2_uc003yzv.2_Missense_Mutation_p.A3V|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_5'Flank|NRBP2_uc010mfl.2_5'Flank|NRBP2_uc010mfm.2_Missense_Mutation_p.A3V|NRBP2_uc011lks.1_Missense_Mutation_p.A3V|NRBP2_uc003yzy.2_Missense_Mutation_p.A3V	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	246	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)															---	---	---	---
EPPK1	83481	broad.mit.edu	37	8	144944907	144944907	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144944907A>C	uc003zaa.1	-	1	2528	c.2515T>G	c.(2515-2517)TCT>GCT	p.S839A		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	839						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144993950	144993950	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144993950C>T	uc003zaf.1	-	32	10620	c.10450G>A	c.(10450-10452)GTG>ATG	p.V3484M	PLEC_uc003zab.1_Missense_Mutation_p.V3347M|PLEC_uc003zac.1_Missense_Mutation_p.V3351M|PLEC_uc003zad.2_Missense_Mutation_p.V3347M|PLEC_uc003zae.1_Missense_Mutation_p.V3315M|PLEC_uc003zag.1_Missense_Mutation_p.V3325M|PLEC_uc003zah.2_Missense_Mutation_p.V3333M|PLEC_uc003zaj.2_Missense_Mutation_p.V3374M	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3484	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
HEATR7A	727957	broad.mit.edu	37	8	145278100	145278100	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145278100C>T	uc003zbk.3	+	14	1542	c.1305C>T	c.(1303-1305)ATC>ATT	p.I435I	HEATR7A_uc011lla.1_Silent_p.I435I|HEATR7A_uc010mft.2_Silent_p.I435I	NM_032450	NP_115826	Q8NDA8	HTR7A_HUMAN	HEAT repeat containing 7A isoform 1	435							binding				0																		---	---	---	---
VPS28	51160	broad.mit.edu	37	8	145649393	145649393	+	Intron	SNP	G	T	T	rs149066828	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145649393G>T	uc003zcr.1	-						VPS28_uc003zcs.1_Intron|VPS28_uc003zct.1_Silent_p.P193P	NM_016208	NP_057292			vacuolar protein sorting 28 isoform 1						cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)															---	---	---	---
NFKBIL2	4796	broad.mit.edu	37	8	145667679	145667679	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145667679G>A	uc011llg.1	-	6	710	c.695C>T	c.(694-696)GCG>GTG	p.A232V		NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	232	TPR 5.				cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)															---	---	---	---
PPP1R16A	84988	broad.mit.edu	37	8	145725483	145725483	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145725483G>A	uc003zdd.2	+	5	1394	c.481G>A	c.(481-483)GCC>ACC	p.A161T	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Missense_Mutation_p.A161T|GPT_uc011lli.1_5'Flank	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	161	ANK 3.					plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)															---	---	---	---
ARHGAP39	80728	broad.mit.edu	37	8	145830920	145830920	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145830920C>T	uc003zdt.1	-	3	635	c.80G>A	c.(79-81)CGG>CAG	p.R27Q	ARHGAP39_uc011llk.1_Missense_Mutation_p.R27Q|ARHGAP39_uc003zds.1_Missense_Mutation_p.R27Q	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	27	WW 1.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0																		---	---	---	---
ZNF7	7553	broad.mit.edu	37	8	146067087	146067087	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:146067087G>A	uc003zeg.3	+	5	732	c.595G>A	c.(595-597)GAG>AAG	p.E199K	ZNF7_uc010mge.2_Missense_Mutation_p.E210K|ZNF7_uc011lln.1_Missense_Mutation_p.E103K|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Missense_Mutation_p.E103K|COMMD5_uc003zel.1_RNA	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	199					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)														---	---	---	---
C8orf33	65265	broad.mit.edu	37	8	146278736	146278736	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:146278736C>T	uc003zfc.3	+	4	511	c.457C>T	c.(457-459)CCC>TCC	p.P153S	C8orf33_uc003zfd.2_RNA	NM_023080	NP_075568	Q9H7E9	CH033_HUMAN	hypothetical protein LOC65265	153											0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)														---	---	---	---
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961			COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)														---	---	---	---
RFX3	5991	broad.mit.edu	37	9	3257056	3257056	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:3257056G>T	uc003zhr.2	-	15	2061	c.1749C>A	c.(1747-1749)CCC>CCA	p.P583P	RFX3_uc010mhd.2_Silent_p.P583P|RFX3_uc003zhs.1_Silent_p.P583P	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	583					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)														---	---	---	---
GLIS3	169792	broad.mit.edu	37	9	3828391	3828391	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:3828391T>C	uc003zhw.1	-	10	2403	c.2209A>G	c.(2209-2211)AGT>GGT	p.S737G	GLIS3_uc003zhx.1_Missense_Mutation_p.S892G|GLIS3_uc010mhf.1_Missense_Mutation_p.S286G|GLIS3_uc003zhv.1_RNA	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	737					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)														---	---	---	---
JAK2	3717	broad.mit.edu	37	9	5022214	5022214	+	Splice_Site	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5022214G>A	uc010mhm.2	+	2	339	c.226_splice	c.e2+1	p.G76_splice	JAK2_uc003ziw.2_Splice_Site_p.G76_splice	NM_004972	NP_004963			Janus kinase 2						actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				---	---	---	---
FREM1	158326	broad.mit.edu	37	9	14851500	14851500	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14851500G>T	uc003zlm.2	-	6	1524	c.934C>A	c.(934-936)CTG>ATG	p.L312M	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	312	CSPG 1.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)														---	---	---	---
KIAA1797	54914	broad.mit.edu	37	9	20789392	20789392	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20789392A>G	uc003zog.1	+	13	1603	c.1240A>G	c.(1240-1242)ACA>GCA	p.T414A		NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	414	Helical; (Potential).					integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)														---	---	---	---
C9orf82	79886	broad.mit.edu	37	9	26842611	26842611	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:26842611A>G	uc003zqc.2	-	6	786	c.774T>C	c.(772-774)AAT>AAC	p.N258N	C9orf82_uc003zqb.2_Silent_p.N113N	NM_024828	NP_079104	Q9H8G2	CI082_HUMAN	hypothetical protein LOC79886	258											0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(42;1.39e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)														---	---	---	---
ACO1	48	broad.mit.edu	37	9	32418455	32418455	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32418455G>A	uc003zqw.3	+	6	759	c.604G>A	c.(604-606)GTG>ATG	p.V202M	ACO1_uc010mjh.1_Missense_Mutation_p.V36M|ACO1_uc003zqx.3_Missense_Mutation_p.V202M|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	202					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)														---	---	---	---
ACO1	48	broad.mit.edu	37	9	32436322	32436322	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32436322C>T	uc003zqw.3	+	18	2329	c.2174C>T	c.(2173-2175)GCC>GTC	p.A725V	ACO1_uc010mjh.1_3'UTR|ACO1_uc003zqx.3_Missense_Mutation_p.A725V|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	725					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)														---	---	---	---
TAF1L	138474	broad.mit.edu	37	9	32631546	32631546	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32631546G>A	uc003zrg.1	-	1	4122	c.4032C>T	c.(4030-4032)TTC>TTT	p.F1344F	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1344					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)														---	---	---	---
TAF1L	138474	broad.mit.edu	37	9	32632408	32632408	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32632408T>C	uc003zrg.1	-	1	3260	c.3170A>G	c.(3169-3171)CAT>CGT	p.H1057R	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1057					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)														---	---	---	---
RECK	8434	broad.mit.edu	37	9	36118810	36118810	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36118810T>G	uc003zyv.2	+	18	2396	c.2310T>G	c.(2308-2310)AGT>AGG	p.S770R	RECK_uc003zyw.2_Missense_Mutation_p.S642R|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	770	Kazal-like 3.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
MELK	9833	broad.mit.edu	37	9	36589613	36589613	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36589613G>A	uc003zzn.2	+	4	363	c.225G>A	c.(223-225)GTG>GTA	p.V75V	MELK_uc011lpm.1_5'UTR|MELK_uc011lpn.1_Silent_p.V75V|MELK_uc011lpo.1_5'UTR|MELK_uc010mll.2_Silent_p.V43V|MELK_uc011lpp.1_Silent_p.V75V|MELK_uc010mlm.2_Intron|MELK_uc011lpq.1_5'UTR|MELK_uc011lpr.1_Silent_p.V75V|MELK_uc011lps.1_Silent_p.V43V	NM_014791	NP_055606	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	75	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:70993145A>G	uc004agr.2	+	2	521	c.292A>G	c.(292-294)ATC>GTC	p.I98V		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2																		---	---	---	---
ANXA1	301	broad.mit.edu	37	9	75784009	75784009	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75784009T>C	uc004ajf.1	+	12	997	c.923T>C	c.(922-924)ATG>ACG	p.M308T	ANXA1_uc004aje.1_Missense_Mutation_p.M308T|ANXA1_uc004ajg.1_Missense_Mutation_p.M308T	NM_000700	NP_000691	P04083	ANXA1_HUMAN	annexin I	308	Annexin 4.				alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)	2		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)													---	---	---	---
TRPM6	140803	broad.mit.edu	37	9	77457094	77457094	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77457094G>T	uc004ajl.1	-	4	556	c.318C>A	c.(316-318)ACC>ACA	p.T106T	TRPM6_uc004ajk.1_Silent_p.T101T|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.T106T|TRPM6_uc010mpd.1_Silent_p.T106T|TRPM6_uc010mpe.1_Silent_p.T106T|TRPM6_uc004ajn.1_Silent_p.T106T	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	106	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
PRUNE2	158471	broad.mit.edu	37	9	79324209	79324209	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79324209T>C	uc010mpk.2	-	8	3105	c.2981A>G	c.(2980-2982)GAA>GGA	p.E994G		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	994					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0																		---	---	---	---
PRUNE2	158471	broad.mit.edu	37	9	79325181	79325181	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79325181G>A	uc010mpk.2	-	8	2133	c.2009C>T	c.(2008-2010)GCG>GTG	p.A670V		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	670					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0																		---	---	---	---
SEMA4D	10507	broad.mit.edu	37	9	92006308	92006308	+	Silent	SNP	G	A	A	rs62638727	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:92006308G>A	uc004aqo.1	-	11	1217	c.645C>T	c.(643-645)GAC>GAT	p.D215D	SEMA4D_uc011ltm.1_Silent_p.D215D|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Silent_p.D213D	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	215	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2																		---	---	---	---
SEMA4D	10507	broad.mit.edu	37	9	92006341	92006341	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:92006341A>G	uc004aqo.1	-						SEMA4D_uc011ltm.1_Intron|SEMA4D_uc011ltn.1_Intron|SEMA4D_uc011lto.1_Intron|SEMA4D_uc004aqp.1_Intron	NM_006378	NP_006369			semaphorin 4D isoform 1						anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2																		---	---	---	---
NFIL3	4783	broad.mit.edu	37	9	94171822	94171822	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:94171822G>A	uc004arh.2	-	2	1590	c.1195C>T	c.(1195-1197)CAT>TAT	p.H399Y		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	399					circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0																		---	---	---	---
ROR2	4920	broad.mit.edu	37	9	94486449	94486449	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:94486449C>T	uc004arj.1	-	9	2526	c.2327G>A	c.(2326-2328)AGC>AAC	p.S776N	ROR2_uc004ari.1_Missense_Mutation_p.S636N	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	776	Ser/Thr-rich.|Cytoplasmic (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20																		---	---	---	---
FAM120A	23196	broad.mit.edu	37	9	96320140	96320140	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96320140G>A	uc004atw.2	+	14	2541	c.2516G>A	c.(2515-2517)CGC>CAC	p.R839H	FAM120A_uc004aty.2_Missense_Mutation_p.R620H|FAM120A_uc004atz.2_Missense_Mutation_p.R488H|FAM120A_uc010mrg.2_Missense_Mutation_p.R152H	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	839	RNA binding.					cytoplasm|plasma membrane	RNA binding				0																		---	---	---	---
SEC61B	10952	broad.mit.edu	37	9	101990194	101990194	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101990194T>C	uc004azh.2	+	3	191	c.115T>C	c.(115-117)TGT>CGT	p.C39R		NM_006808	NP_006799	P60468	SC61B_HUMAN	Sec61 beta subunit	39	Cytoplasmic (Potential).			C->S: Abolishes S-acylation.	ER-associated protein catabolic process|protein import into nucleus, translocation|retrograde protein transport, ER to cytosol|transmembrane transport	endoplasmic reticulum Sec complex|integral to membrane	epidermal growth factor binding				0		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
OR13C3	138803	broad.mit.edu	37	9	107298417	107298417	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:107298417A>G	uc004bcb.1	-	1	678	c.678T>C	c.(676-678)ATT>ATC	p.I226I		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	226	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1																		---	---	---	---
PTPN3	5774	broad.mit.edu	37	9	112153484	112153484	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:112153484G>A	uc004bed.2	-						PTPN3_uc004beb.2_Intron|PTPN3_uc004bec.2_Intron|PTPN3_uc010mtu.2_Intron|PTPN3_uc011lwg.1_Intron|PTPN3_uc011lwh.1_Intron|PTPN3_uc011lwd.1_Intron|PTPN3_uc011lwe.1_Intron|PTPN3_uc011lwf.1_Intron	NM_002829	NP_002820			protein tyrosine phosphatase, non-receptor type						negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3																		---	---	---	---
TXNDC8	255220	broad.mit.edu	37	9	113091532	113091532	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:113091532C>T	uc004bes.2	-	3	218	c.169G>A	c.(169-171)GTG>ATG	p.V57M	TXNDC8_uc011lwl.1_Intron	NM_001003936	NP_001003936	Q6A555	TXND8_HUMAN	thioredoxin domain containing 8	57	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	Golgi apparatus	electron carrier activity|protein disulfide oxidoreductase activity				0																		---	---	---	---
KIAA0368	23392	broad.mit.edu	37	9	114172450	114172450	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114172450G>T	uc004bfe.1	-	24	2955	c.2955C>A	c.(2953-2955)GCC>GCA	p.A985A		NM_001080398	NP_001073867			KIAA0368 protein												0																		---	---	---	---
ZNF483	158399	broad.mit.edu	37	9	114305051	114305051	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114305051C>T	uc004bff.2	+	6	2060	c.1836C>T	c.(1834-1836)TGC>TGT	p.C612C	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	612	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1																		---	---	---	---
SLC31A2	1318	broad.mit.edu	37	9	115925105	115925105	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115925105G>A	uc004bgq.2	+	4	457	c.340G>A	c.(340-342)GTA>ATA	p.V114I		NM_001860	NP_001851	O15432	COPT2_HUMAN	solute carrier family 31 (copper transporters),	114	Helical; (Potential).					integral to plasma membrane	copper ion transmembrane transporter activity				0																		---	---	---	---
DBC1	1620	broad.mit.edu	37	9	122004313	122004313	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:122004313C>T	uc004bkc.2	-						DBC1_uc004bkd.2_Intron	NM_014618	NP_055433			deleted in bladder cancer 1 precursor						cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8																		---	---	---	---
TRAF1	7185	broad.mit.edu	37	9	123675628	123675628	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123675628C>T	uc004bku.1	-	5	1255	c.683G>A	c.(682-684)CGC>CAC	p.R228H	TRAF1_uc011lyg.1_Missense_Mutation_p.R106H|TRAF1_uc010mvl.1_Missense_Mutation_p.R228H	NM_005658	NP_005649	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	228					apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			skin(2)|ovary(1)	3																		---	---	---	---
TTLL11	158135	broad.mit.edu	37	9	124752027	124752027	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124752027T>G	uc004blt.1	-	4	1174	c.986A>C	c.(985-987)GAC>GCC	p.D329A	TTLL11_uc011lyl.1_Missense_Mutation_p.D329A|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Missense_Mutation_p.D6A|TTLL11_uc004blu.1_Nonstop_Mutation_p.*284C	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	329	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0																		---	---	---	---
OR1N1	138883	broad.mit.edu	37	9	125288709	125288709	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125288709A>G	uc004bmn.1	-	1	864	c.864T>C	c.(862-864)TAT>TAC	p.Y288Y		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3																		---	---	---	---
STRBP	55342	broad.mit.edu	37	9	125932264	125932264	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125932264C>T	uc004bns.2	-	6	882	c.452G>A	c.(451-453)CGG>CAG	p.R151Q	STRBP_uc004bnt.2_5'UTR|STRBP_uc004bnu.2_Missense_Mutation_p.R137Q|STRBP_uc004bnv.2_Missense_Mutation_p.R151Q	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	151	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2																		---	---	---	---
PBX3	5090	broad.mit.edu	37	9	128692121	128692121	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:128692121C>T	uc004bqb.2	+	4	820	c.704C>T	c.(703-705)GCC>GTC	p.A235V	PBX3_uc004bqc.2_Missense_Mutation_p.A54V|PBX3_uc004bqd.2_Missense_Mutation_p.A54V|PBX3_uc011lzw.1_Missense_Mutation_p.A160V|PBX3_uc011lzx.1_Missense_Mutation_p.A146V|PBX3_uc004bqe.2_Missense_Mutation_p.A122V	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	235	Homeobox; TALE-type.				anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
TOR2A	27433	broad.mit.edu	37	9	130496638	130496638	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130496638G>A	uc004brs.3	-	2	412	c.357C>T	c.(355-357)CGC>CGT	p.R119R	TOR2A_uc004brt.3_Silent_p.R119R|TOR2A_uc004brw.3_Silent_p.R119R|TOR2A_uc011maj.1_Intron|TOR2A_uc004bru.3_Intron|TOR2A_uc004brv.3_Intron|TOR2A_uc004brx.1_5'UTR	NM_001085347	NP_001078816	Q5JU69	TOR2A_HUMAN	torsin family 2, member A isoform a	119					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum|extracellular region	ATP binding|nucleoside-triphosphatase activity				0																OREG0019509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GOLGA2	2801	broad.mit.edu	37	9	131019737	131019737	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131019737C>T	uc011maw.1	-	25	2718	c.2705G>A	c.(2704-2706)AGA>AAA	p.R902K	GOLGA2_uc010mxw.2_Missense_Mutation_p.R225K|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	902						Golgi cisterna membrane	protein binding			ovary(1)	1																		---	---	---	---
GOLGA2	2801	broad.mit.edu	37	9	131020100	131020100	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131020100G>A	uc011maw.1	-	23	2512	c.2499C>T	c.(2497-2499)TGC>TGT	p.C833C	GOLGA2_uc010mxw.2_Silent_p.C156C|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	833	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1																		---	---	---	---
SPTAN1	6709	broad.mit.edu	37	9	131339690	131339690	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131339690A>G	uc004bvl.3	+	8	1103	c.990A>G	c.(988-990)ACA>ACG	p.T330T	SPTAN1_uc011mbg.1_Silent_p.T330T|SPTAN1_uc011mbh.1_Silent_p.T342T|SPTAN1_uc004bvm.3_Silent_p.T330T|SPTAN1_uc004bvn.3_Silent_p.T330T	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	330	Spectrin 4.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10																		---	---	---	---
SPTAN1	6709	broad.mit.edu	37	9	131375680	131375680	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131375680C>T	uc004bvl.3	+	39	5162	c.5049C>T	c.(5047-5049)TCC>TCT	p.S1683S	SPTAN1_uc004bvm.3_Silent_p.S1688S|SPTAN1_uc004bvn.3_Silent_p.S1663S	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1683	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10																		---	---	---	---
CRAT	1384	broad.mit.edu	37	9	131864220	131864220	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131864220G>A	uc004bxh.2	-	6	1029	c.747C>T	c.(745-747)GGC>GGT	p.G249G	CRAT_uc004bxg.2_Silent_p.G228G|CRAT_uc004bxk.3_Silent_p.G228G	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	249					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)													---	---	---	---
LAMC3	10319	broad.mit.edu	37	9	133951311	133951311	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133951311G>T	uc004caa.1	+	21	3686	c.3588G>T	c.(3586-3588)GAG>GAT	p.E1196D		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1196	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)														---	---	---	---
GTF3C4	9329	broad.mit.edu	37	9	135553705	135553705	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135553705C>T	uc010mzv.2	+	2	957	c.699C>T	c.(697-699)CTC>CTT	p.L233L	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	233					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)														---	---	---	---
RALGDS	5900	broad.mit.edu	37	9	136004600	136004600	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136004600C>T	uc004ccr.2	-	1	189	c.106G>A	c.(106-108)GCC>ACC	p.A36T	RALGDS_uc011mcv.1_Intron|RALGDS_uc004ccs.2_Intron|RALGDS_uc011mcw.1_Intron	NM_001042368	NP_001035827	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	Error:Variant_position_missing_in_Q12967_after_alignment					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)				T	CIITA	PMBL|Hodgkin Lymphona|								---	---	---	---
SLC2A6	11182	broad.mit.edu	37	9	136337261	136337261	+	Missense_Mutation	SNP	G	A	A	rs146699447		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136337261G>A	uc004cee.2	-	10	1501	c.1406C>T	c.(1405-1407)GCG>GTG	p.A469V	SLC2A6_uc004cef.2_Missense_Mutation_p.A407V|SLC2A6_uc004ceg.2_Missense_Mutation_p.A446V	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	469	Helical; Name=12; (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)														---	---	---	---
BRD3	8019	broad.mit.edu	37	9	136906997	136906997	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136906997G>A	uc004cew.2	-	8	1480	c.1292C>T	c.(1291-1293)CCC>CTC	p.P431L	BRD3_uc004cex.2_Missense_Mutation_p.P431L	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	431						nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)				T	NUT|C15orf55	lethal midline carcinoma of young people								---	---	---	---
OLFM1	10439	broad.mit.edu	37	9	137998610	137998610	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:137998610C>T	uc010nar.2	+	5	1008	c.692C>T	c.(691-693)ACG>ATG	p.T231M	OLFM1_uc004cfl.3_Missense_Mutation_p.T213M|OLFM1_uc004cfn.3_Translation_Start_Site	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	231	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)														---	---	---	---
KIAA0649	9858	broad.mit.edu	37	9	138376423	138376423	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138376423G>A	uc004cfr.1	+	4	616	c.67G>A	c.(67-69)GGG>AGG	p.G23R		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	23						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)														---	---	---	---
QSOX2	169714	broad.mit.edu	37	9	139100732	139100732	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139100732C>T	uc010nbi.2	-	12	1977	c.1939G>A	c.(1939-1941)GGG>AGG	p.G647R		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	647					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)														---	---	---	---
SEC16A	9919	broad.mit.edu	37	9	139368937	139368937	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139368937A>G	uc004chx.2	-	3	3440	c.3131T>C	c.(3130-3132)GTC>GCC	p.V1044A	SEC16A_uc004chv.3_Missense_Mutation_p.V434A|SEC16A_uc004chw.2_Missense_Mutation_p.V1044A|SEC16A_uc010nbn.2_Missense_Mutation_p.V1044A|SEC16A_uc010nbo.1_Missense_Mutation_p.V1044A	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	866					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)														---	---	---	---
NOTCH1	4851	broad.mit.edu	37	9	139395218	139395218	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139395218G>A	uc004chz.2	-	31	5720	c.5720C>T	c.(5719-5721)CCG>CTG	p.P1907L		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1907	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)				T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---	---
NELF	26012	broad.mit.edu	37	9	140350863	140350863	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140350863G>A	uc004cna.2	-	4	936	c.704C>T	c.(703-705)GCC>GTC	p.A235V	C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_5'Flank|NELF_uc010nci.2_Missense_Mutation_p.A3V|NELF_uc011mey.1_RNA|NELF_uc011mez.1_Missense_Mutation_p.A235V|NELF_uc004cmz.2_Missense_Mutation_p.A235V|NELF_uc004cnc.2_Missense_Mutation_p.A235V|NELF_uc004cnb.2_Missense_Mutation_p.A235V	NM_001130969	NP_001124441	Q6X4W1	NELF_HUMAN	nasal embryonic LHRH factor isoform a	235						nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)														---	---	---	---
EHMT1	79813	broad.mit.edu	37	9	140672338	140672338	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140672338G>A	uc011mfc.1	+	13	2060	c.2023G>A	c.(2023-2025)GCC>ACC	p.A675T	EHMT1_uc004coa.2_Missense_Mutation_p.A675T|EHMT1_uc004cob.1_Missense_Mutation_p.A644T	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	675					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)														---	---	---	---
CACNB2	783	broad.mit.edu	37	10	18828201	18828201	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:18828201C>T	uc001ipr.2	+	14	1591	c.1531C>T	c.(1531-1533)CGT>TGT	p.R511C	CACNB2_uc009xjz.1_Missense_Mutation_p.R261C|CACNB2_uc001ips.2_Missense_Mutation_p.R487C|CACNB2_uc001ipt.2_Missense_Mutation_p.R473C|CACNB2_uc001ipu.2_Missense_Mutation_p.R483C|CACNB2_uc001ipv.2_Missense_Mutation_p.R459C|CACNB2_uc009xka.1_Missense_Mutation_p.R445C|CACNB2_uc001ipw.2_Missense_Mutation_p.R418C|CACNB2_uc001ipx.2_Missense_Mutation_p.R456C|CACNB2_uc001ipz.2_Missense_Mutation_p.R433C|CACNB2_uc001ipy.2_Missense_Mutation_p.R457C|CACNB2_uc010qco.1_Missense_Mutation_p.R425C|CACNB2_uc001iqa.2_Missense_Mutation_p.R463C|NSUN6_uc001iqb.2_RNA	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	511					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)													---	---	---	---
CACNB2	783	broad.mit.edu	37	10	18828645	18828645	+	Missense_Mutation	SNP	C	T	T	rs77141223	byFrequency;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:18828645C>T	uc001ipr.2	+	14	2035	c.1975C>T	c.(1975-1977)CGC>TGC	p.R659C	CACNB2_uc009xjz.1_Missense_Mutation_p.R409C|CACNB2_uc001ips.2_Missense_Mutation_p.R635C|CACNB2_uc001ipt.2_Missense_Mutation_p.R621C|CACNB2_uc001ipu.2_Missense_Mutation_p.R631C|CACNB2_uc001ipv.2_Missense_Mutation_p.R607C|CACNB2_uc009xka.1_Missense_Mutation_p.R593C|CACNB2_uc001ipw.2_Missense_Mutation_p.R566C|CACNB2_uc001ipx.2_Missense_Mutation_p.R604C|CACNB2_uc001ipz.2_Missense_Mutation_p.R581C|CACNB2_uc001ipy.2_Missense_Mutation_p.R605C|CACNB2_uc010qco.1_Missense_Mutation_p.R573C|CACNB2_uc001iqa.2_Missense_Mutation_p.R611C|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	659				R -> P (in Ref. 2; AAB53332, 5; AAG01473/ AAL16948/AAL16951/AAL16950 and 6; AAL73495).	axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)													---	---	---	---
PIP4K2A	5305	broad.mit.edu	37	10	22856622	22856622	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:22856622C>T	uc001irl.3	-						PIP4K2A_uc010qcu.1_Intron	NM_005028	NP_005019			phosphatidylinositol-5-phosphate 4-kinase, type								1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2																		---	---	---	---
GPR158	57512	broad.mit.edu	37	10	25887199	25887199	+	Missense_Mutation	SNP	G	A	A	rs141827771	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:25887199G>A	uc001isj.2	+	11	2704	c.2644G>A	c.(2644-2646)GCT>ACT	p.A882T	GPR158_uc001isk.2_Missense_Mutation_p.A257T	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	882	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8																		---	---	---	---
PTCHD3	374308	broad.mit.edu	37	10	27692254	27692254	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27692254G>A	uc001itu.2	-	3	1362	c.1244C>T	c.(1243-1245)GCG>GTG	p.A415V		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	415	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
PTCHD3	374308	broad.mit.edu	37	10	27702568	27702568	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27702568G>A	uc001itu.2	-	1	730	c.612C>T	c.(610-612)ACC>ACT	p.T204T		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	204					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
SVIL	6840	broad.mit.edu	37	10	29819525	29819525	+	Intron	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:29819525G>T	uc001iut.1	-						SVIL_uc001iuu.1_Intron	NM_021738	NP_068506			supervillin isoform 2						cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)																---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34408562	34408562	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34408562C>T	uc010qej.1	-	24	3656	c.3656G>A	c.(3655-3657)CGC>CAC	p.R1219H	PARD3_uc010qek.1_Missense_Mutation_p.R1216H|PARD3_uc010qel.1_Missense_Mutation_p.R1182H|PARD3_uc010qem.1_Missense_Mutation_p.R1203H|PARD3_uc010qen.1_Missense_Mutation_p.R1173H|PARD3_uc010qeo.1_Missense_Mutation_p.R1136H|PARD3_uc010qep.1_Missense_Mutation_p.R1129H|PARD3_uc010qeq.1_Missense_Mutation_p.R1107H	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1219	Potential.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
FZD8	8325	broad.mit.edu	37	10	35929176	35929176	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:35929176C>T	uc001iyz.1	-	1	1187	c.1182G>A	c.(1180-1182)GCG>GCA	p.A394A		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	394	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0																		---	---	---	---
RET	5979	broad.mit.edu	37	10	43598065	43598065	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43598065A>G	uc001jal.2	+	3	803	c.613A>G	c.(613-615)AGG>GGG	p.R205G	RET_uc001jak.1_Missense_Mutation_p.R205G|RET_uc010qez.1_5'Flank	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	205	Cadherin.|Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				---	---	---	---
RET	5979	broad.mit.edu	37	10	43620416	43620416	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43620416A>G	uc001jal.2	+	18	3215	c.3025A>G	c.(3025-3027)ATG>GTG	p.M1009V	RET_uc001jak.1_Missense_Mutation_p.M1009V|RET_uc010qez.1_Missense_Mutation_p.M755V	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	1009	Protein kinase.|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				---	---	---	---
ZNF32	7580	broad.mit.edu	37	10	44139887	44139887	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:44139887G>A	uc001jbb.2	-	3	622	c.433C>T	c.(433-435)CGA>TGA	p.R145*	uc001jba.2_Intron|ZNF32_uc001jbc.2_Nonsense_Mutation_p.R145*	NM_001005368	NP_001005368	P17041	ZNF32_HUMAN	zinc finger protein 32	145	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)														---	---	---	---
RASSF4	83937	broad.mit.edu	37	10	45478096	45478096	+	Missense_Mutation	SNP	G	A	A	rs145855403	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45478096G>A	uc001jbo.2	+	4	400	c.266G>A	c.(265-267)CGG>CAG	p.R89Q	RASSF4_uc001jbp.2_Missense_Mutation_p.R120Q|RASSF4_uc009xmn.2_Missense_Mutation_p.R19Q|RASSF4_uc001jbq.2_Missense_Mutation_p.G17S|RASSF4_uc001jbt.2_Missense_Mutation_p.R19Q	NM_032023	NP_114412	Q9H2L5	RASF4_HUMAN	Ras association domain family 4	89					cell cycle|signal transduction		protein binding			large_intestine(1)	1																		---	---	---	---
OR13A1	79290	broad.mit.edu	37	10	45799648	45799648	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45799648C>T	uc001jcc.1	-	4	532	c.223G>A	c.(223-225)GCT>ACT	p.A75T	OR13A1_uc001jcd.1_Missense_Mutation_p.A71T	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61829489	61829489	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61829489T>G	uc001jky.2	-	37	11342	c.11150A>C	c.(11149-11151)AAG>ACG	p.K3717T	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3717					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61836200	61836200	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61836200C>T	uc001jky.2	-	37	4631	c.4439G>A	c.(4438-4440)CGG>CAG	p.R1480Q	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron|ANK3_uc009xpc.1_RNA	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1480					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
ZNF365	22891	broad.mit.edu	37	10	64136336	64136336	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64136336C>A	uc001jmc.2	+	2	699	c.384C>A	c.(382-384)ACC>ACA	p.T128T	ZNF365_uc001jly.3_Silent_p.T143T|ZNF365_uc001jmb.3_Silent_p.T128T|ZNF365_uc001jlz.3_Silent_p.T128T|ZNF365_uc001jma.3_Intron	NM_199451	NP_955523	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform C	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)																	---	---	---	---
JMJD1C	221037	broad.mit.edu	37	10	64952810	64952810	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64952810G>A	uc001jmn.2	-	16	6264	c.5964C>T	c.(5962-5964)AGC>AGT	p.S1988S	JMJD1C_uc001jml.2_Silent_p.S1751S|JMJD1C_uc001jmm.2_Silent_p.S1700S|JMJD1C_uc010qiq.1_Silent_p.S1806S|JMJD1C_uc009xpi.2_Silent_p.S1806S|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_5'Flank|JMJD1C_uc009xpk.1_Silent_p.S886S	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1988					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)																	---	---	---	---
JMJD1C	221037	broad.mit.edu	37	10	64954088	64954088	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64954088C>T	uc001jmn.2	-	14	5992	c.5692G>A	c.(5692-5694)GAT>AAT	p.D1898N	JMJD1C_uc001jml.2_Missense_Mutation_p.D1679N|JMJD1C_uc001jmm.2_Missense_Mutation_p.D1610N|JMJD1C_uc010qiq.1_Missense_Mutation_p.D1716N|JMJD1C_uc009xpi.2_Missense_Mutation_p.D1716N|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.D796N	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1898					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)																	---	---	---	---
HK1	3098	broad.mit.edu	37	10	71158533	71158533	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71158533G>A	uc001jpl.3	+	17	2659	c.2558G>A	c.(2557-2559)CGT>CAT	p.R853H	HK1_uc001jpg.3_Missense_Mutation_p.R841H|HK1_uc001jph.3_Missense_Mutation_p.R857H|HK1_uc001jpi.3_Missense_Mutation_p.R857H|HK1_uc001jpj.3_Missense_Mutation_p.R888H|HK1_uc001jpk.3_Missense_Mutation_p.R852H	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	853	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1																		---	---	---	---
C10orf27	219793	broad.mit.edu	37	10	72539371	72539371	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72539371A>G	uc001jrj.1	-	5	795	c.405T>C	c.(403-405)AAT>AAC	p.N135N	C10orf27_uc010qjm.1_Silent_p.N135N|C10orf27_uc009xqh.1_RNA|C10orf27_uc010qjn.1_Silent_p.N135N|C10orf27_uc009xqi.1_Intron|C10orf27_uc010qjo.1_Silent_p.N124N|C10orf27_uc009xqj.1_Missense_Mutation_p.I130T|C10orf27_uc010qjp.1_Silent_p.N124N	NM_152710	NP_689923	Q96M53	SPATL_HUMAN	stromal protein associated with thymii and lymph	135					cell differentiation|multicellular organismal development|spermatogenesis	cytosol				skin(1)	1																		---	---	---	---
UNC5B	219699	broad.mit.edu	37	10	73050685	73050685	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73050685A>G	uc001jro.2	+	9	1558	c.1113A>G	c.(1111-1113)TCA>TCG	p.S371S	UNC5B_uc001jrp.2_Silent_p.S360S	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	371	Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3																		---	---	---	---
USP54	159195	broad.mit.edu	37	10	75265090	75265090	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75265090T>G	uc001juo.2	-	19	4163	c.4146A>C	c.(4144-4146)GAA>GAC	p.E1382D	USP54_uc010qkk.1_Missense_Mutation_p.E564D|USP54_uc001juk.2_Missense_Mutation_p.E470D|USP54_uc001jul.2_Missense_Mutation_p.E470D|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1382					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)																	---	---	---	---
NDST2	8509	broad.mit.edu	37	10	75567582	75567582	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75567582G>A	uc001jvk.2	-	3	1369	c.565C>T	c.(565-567)CTT>TTT	p.L189F	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Missense_Mutation_p.L66F|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Missense_Mutation_p.L66F	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	189	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)																	---	---	---	---
ZMIZ1	57178	broad.mit.edu	37	10	81058854	81058854	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:81058854G>A	uc001kaf.2	+	16	2286	c.1714G>A	c.(1714-1716)GTG>ATG	p.V572M	ZMIZ1_uc001kag.2_Missense_Mutation_p.V448M	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	572					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)															---	---	---	---
SFTPA2	729238	broad.mit.edu	37	10	81319123	81319123	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:81319123G>A	uc001kal.3	-	3	214	c.117C>T	c.(115-117)CAC>CAT	p.H39H	SFTPA2_uc001kan.3_Silent_p.H39H|SFTPA2_uc001kam.2_RNA	NM_006926	NP_008857	Q8IWL1	SFPA2_HUMAN	RecName: Full=Pulmonary surfactant-associated protein A2;          Short=SP-A2;          Short=SP-A;          Short=PSP-A;          Short=PSPA; AltName: Full=Alveolar proteinosis protein; AltName: Full=35 kDa pulmonary surfactant-associated protein; Flags: Precursor;	39	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)											Pulmonary_Fibrosis_Idiopathic				---	---	---	---
WAPAL	23063	broad.mit.edu	37	10	88260114	88260114	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88260114A>G	uc001kdo.2	-	3	1328	c.886T>C	c.(886-888)TAC>CAC	p.Y296H	WAPAL_uc001kdn.2_Missense_Mutation_p.Y339H|WAPAL_uc009xsw.2_Missense_Mutation_p.Y296H	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	296	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1																		---	---	---	---
PAPSS2	9060	broad.mit.edu	37	10	89472990	89472990	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:89472990C>T	uc001kex.2	+	3	567	c.304C>T	c.(304-306)CGG>TGG	p.R102W	PAPSS2_uc001kew.2_Missense_Mutation_p.R102W|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	102	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)														---	---	---	---
CYP26C1	340665	broad.mit.edu	37	10	94828126	94828126	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94828126C>T	uc010qns.1	+	6	1241	c.1241C>T	c.(1240-1242)ACG>ATG	p.T414M	CYP26C1_uc009xud.2_RNA	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	414					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)																---	---	---	---
BLNK	29760	broad.mit.edu	37	10	97969609	97969609	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97969609G>A	uc001kls.3	-	9	909	c.731C>T	c.(730-732)CCG>CTG	p.P244L	BLNK_uc001kme.3_Missense_Mutation_p.P139L|BLNK_uc001klt.3_Missense_Mutation_p.P135L|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Missense_Mutation_p.P162L|BLNK_uc001klv.3_Missense_Mutation_p.P139L|BLNK_uc001klw.3_Intron|BLNK_uc001klx.3_Missense_Mutation_p.P221L|BLNK_uc001kly.3_Missense_Mutation_p.P244L|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Missense_Mutation_p.P221L|BLNK_uc001kmb.3_Missense_Mutation_p.P40L|BLNK_uc001kmc.3_Intron|BLNK_uc001kmd.3_Missense_Mutation_p.P162L|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	244	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)														---	---	---	---
FRAT2	23401	broad.mit.edu	37	10	99093646	99093646	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99093646G>T	uc001knd.1	-	1	813	c.684C>A	c.(682-684)CCC>CCA	p.P228P		NM_012083	NP_036215	O75474	FRAT2_HUMAN	GSK-3 binding protein FRAT2	228					cell proliferation|multicellular organismal development|Wnt receptor signaling pathway						0		Colorectal(252;0.0846)		Epithelial(162;1.34e-09)|all cancers(201;8.42e-08)														---	---	---	---
DHDPSL	112817	broad.mit.edu	37	10	99371285	99371285	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99371285A>G	uc001kny.2	+	7	1212	c.853A>G	c.(853-855)ATC>GTC	p.I285V	DHDPSL_uc001knz.2_Missense_Mutation_p.I122V|PI4K2A_uc010qoy.1_Intron	NM_138413	NP_612422	Q86XE5	HOGA1_HUMAN	DHDPS-like protein isoform 1	285					glyoxylate catabolic process	mitochondrion	4-hydroxy-2-oxoglutarate aldolase activity				0																		---	---	---	---
CNNM1	26507	broad.mit.edu	37	10	101147615	101147615	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101147615C>T	uc001kpp.3	+	8	2668	c.2379C>T	c.(2377-2379)TGC>TGT	p.C793C	CNNM1_uc010qpi.1_Silent_p.C814C|CNNM1_uc009xwf.2_Silent_p.C793C|CNNM1_uc009xwg.2_Silent_p.C193C	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	793					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)														---	---	---	---
GOT1	2805	broad.mit.edu	37	10	101157324	101157324	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101157324C>T	uc001kpr.2	-	9	1430	c.1222G>A	c.(1222-1224)GCA>ACA	p.A408T	GOT1_uc009xwh.2_RNA|GOT1_uc001kpq.1_Missense_Mutation_p.A121T	NM_002079	NP_002070	P17174	AATC_HUMAN	aspartate aminotransferase 1	408					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding				0		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)													---	---	---	---
HPS6	79803	broad.mit.edu	37	10	103826348	103826348	+	Missense_Mutation	SNP	G	T	T	rs140222296		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103826348G>T	uc001kuj.2	+	1	1202	c.1117G>T	c.(1117-1119)GGG>TGG	p.G373W		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	373						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)										Hermansky-Pudlak_syndrome				---	---	---	---
PPRC1	23082	broad.mit.edu	37	10	103908180	103908180	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103908180G>A	uc001kum.2	+	10	4491	c.4452G>A	c.(4450-4452)TCG>TCA	p.S1484S	PPRC1_uc001kun.2_Silent_p.S1364S|PPRC1_uc010qqj.1_Silent_p.S1220S|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1484	Arg-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)														---	---	---	---
NOLC1	9221	broad.mit.edu	37	10	103919311	103919311	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103919311T>C	uc001kuo.2	+	7	1080	c.845T>C	c.(844-846)ATG>ACG	p.M282T	NOLC1_uc001kup.2_Missense_Mutation_p.M292T|NOLC1_uc001kuq.2_Missense_Mutation_p.M283T|NOLC1_uc009xxb.1_Missense_Mutation_p.M1T|NOLC1_uc001kur.2_Missense_Mutation_p.M1T	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	282	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)														---	---	---	---
TCF7L2	6934	broad.mit.edu	37	10	114925566	114925566	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114925566C>T	uc001lae.3	+	14	2151	c.1644C>T	c.(1642-1644)TCC>TCT	p.S548S	TCF7L2_uc001lac.3_Silent_p.S542S|TCF7L2_uc010qrk.1_3'UTR|TCF7L2_uc010qrl.1_Silent_p.S525S|TCF7L2_uc010qrm.1_3'UTR|TCF7L2_uc010qrn.1_3'UTR|TCF7L2_uc001lad.3_3'UTR|TCF7L2_uc001lag.3_3'UTR|TCF7L2_uc001laf.3_Silent_p.S525S|TCF7L2_uc010qro.1_3'UTR|TCF7L2_uc001lah.2_3'UTR|TCF7L2_uc010qrp.1_3'UTR|TCF7L2_uc010qrq.1_3'UTR|TCF7L2_uc010qrr.1_Silent_p.S480S|TCF7L2_uc010qrs.1_Silent_p.S436S|TCF7L2_uc010qrt.1_Silent_p.S436S|TCF7L2_uc010qru.1_3'UTR|TCF7L2_uc010qrv.1_3'UTR|TCF7L2_uc010qrw.1_3'UTR|TCF7L2_uc010qrx.1_3'UTR	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	565					anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)														---	---	---	---
NRAP	4892	broad.mit.edu	37	10	115356939	115356939	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115356939T>C	uc001laj.2	-	37	4501	c.4337A>G	c.(4336-4338)AAG>AGG	p.K1446R	NRAP_uc009xyb.2_Missense_Mutation_p.K235R|NRAP_uc001lak.2_Missense_Mutation_p.K1411R|NRAP_uc001lal.3_Missense_Mutation_p.K1446R	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1446	Nebulin 38.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)														---	---	---	---
FAM160B1	57700	broad.mit.edu	37	10	116603678	116603678	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116603678T>C	uc001lcb.2	+	7	1330	c.995T>C	c.(994-996)GTG>GCG	p.V332A	FAM160B1_uc001lcc.2_Missense_Mutation_p.V332A	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	332										lung(1)	1																		---	---	---	---
FOXI2	399823	broad.mit.edu	37	10	129536818	129536818	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129536818C>T	uc009yas.2	+	2	546	c.546C>T	c.(544-546)TGC>TGT	p.C182C	uc009yar.1_5'Flank	NM_207426	NP_997309	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	182	Fork-head.				epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)																---	---	---	---
GPR123	84435	broad.mit.edu	37	10	134942261	134942261	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134942261G>A	uc001llx.3	+	7	1365	c.929G>A	c.(928-930)CGT>CAT	p.R310H	GPR123_uc001llw.2_Missense_Mutation_p.R1029H	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	310	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)														---	---	---	---
MUC6	4588	broad.mit.edu	37	11	1031986	1031986	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1031986G>A	uc001lsw.2	-	3	234	c.183C>T	c.(181-183)TAC>TAT	p.Y61Y		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	61	VWFD 1.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
MUC5B	727897	broad.mit.edu	37	11	1215491	1215491	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1215491G>A	uc009ycr.1	+						uc001lsz.2_RNA	NM_017511	NP_059981			SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;						cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---
MUC5B	727897	broad.mit.edu	37	11	1265996	1265996	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1265996C>T	uc009ycr.1	+	48	9926	c.9800C>T	c.(9799-9801)ACG>ATG	p.T3267M	MUC5B_uc001ltb.2_Missense_Mutation_p.T2632M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2629	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			Missing (in Ref. 6; AAB61398).|RTL -> LTP (in Ref. 4; CAA96577).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---
MUC5B	727897	broad.mit.edu	37	11	1275928	1275928	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1275928T>C	uc009ycr.1	+	57	16619	c.16493T>C	c.(16492-16494)CTG>CCG	p.L5498P	MUC5B_uc001ltb.2_Missense_Mutation_p.L5164P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5161	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---
MOB2	81532	broad.mit.edu	37	11	1491656	1491656	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1491656C>T	uc010qwz.1	-	5	743	c.553G>A	c.(553-555)GTG>ATG	p.V185M	MOB2_uc001lto.1_Missense_Mutation_p.V69M|MOB2_uc001ltp.1_Translation_Start_Site|MOB2_uc001ltq.1_Missense_Mutation_p.V148M|MOB2_uc010qwy.1_Missense_Mutation_p.V69M	NM_053005	NP_443731	Q70IA6	MOB2_HUMAN	HCCA2 protein	154						nucleus|perinuclear region of cytoplasm	metal ion binding				0																		---	---	---	---
OR51E1	143503	broad.mit.edu	37	11	4674677	4674677	+	Silent	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4674677A>T	uc001lzi.3	+	2	1065	c.921A>T	c.(919-921)CGA>CGT	p.R307R		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR51B5	282763	broad.mit.edu	37	11	5364052	5364052	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5364052C>G	uc001map.1	-	1	703	c.703G>C	c.(703-705)GCT>CCT	p.A235P	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
OR52H1	390067	broad.mit.edu	37	11	5565865	5565865	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5565865G>T	uc010qzh.1	-	1	889	c.889C>A	c.(889-891)CCC>ACC	p.P297T	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	297	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
TRIM5	85363	broad.mit.edu	37	11	5701403	5701403	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5701403G>A	uc001mbm.1	-	2	262	c.5C>T	c.(4-6)GCT>GTT	p.A2V	TRIM5_uc001mbq.1_Missense_Mutation_p.A2V|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Missense_Mutation_p.A2V|TRIM5_uc001mbo.2_Missense_Mutation_p.A2V|TRIM5_uc001mbp.2_Missense_Mutation_p.A2V	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	2					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)														---	---	---	---
TRIM22	10346	broad.mit.edu	37	11	5809074	5809074	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5809074T>C	uc009yet.1	+						TRIM5_uc001mbq.1_Intron	NM_006074	NP_006065			tripartite motif-containing 22						immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)														---	---	---	---
APBB1	322	broad.mit.edu	37	11	6422212	6422212	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6422212C>T	uc001mdb.1	-						APBB1_uc001mcz.1_Intron|APBB1_uc001mdd.3_Intron|APBB1_uc001mda.2_Intron|APBB1_uc001mdc.1_Intron|APBB1_uc010rab.1_Intron	NM_001164	NP_001155			amyloid beta A4 precursor protein-binding,						apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)														---	---	---	---
RRP8	23378	broad.mit.edu	37	11	6622259	6622259	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6622259A>G	uc001med.2	-	4	1023	c.944T>C	c.(943-945)TTC>TCC	p.F315S	ILK_uc001mee.2_5'Flank|ILK_uc001mef.2_5'Flank|ILK_uc010rap.1_5'Flank|ILK_uc010raq.1_5'Flank|ILK_uc001meg.2_5'Flank|ILK_uc001meh.2_5'Flank	NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	315					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0																		---	---	---	---
RBMXL2	27288	broad.mit.edu	37	11	7110454	7110454	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7110454G>A	uc001mfc.2	+	1	290	c.103G>A	c.(103-105)GTC>ATC	p.V35I		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	35	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)														---	---	---	---
RBMXL2	27288	broad.mit.edu	37	11	7111029	7111029	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7111029C>T	uc001mfc.2	+	1	865	c.678C>T	c.(676-678)CGC>CGT	p.R226R		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	226	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)														---	---	---	---
SPON1	10418	broad.mit.edu	37	11	14284395	14284395	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14284395C>T	uc001mle.2	+	16	2672	c.2134C>T	c.(2134-2136)CGA>TGA	p.R712*		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	712	TSP type-1 5.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)														---	---	---	---
PDE3B	5140	broad.mit.edu	37	11	14808053	14808053	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14808053T>C	uc001mln.2	+	3	1453	c.1100T>C	c.(1099-1101)CTG>CCG	p.L367P	PDE3B_uc010rcr.1_Missense_Mutation_p.L367P	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	367					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0																		---	---	---	---
MYOD1	4654	broad.mit.edu	37	11	17741405	17741405	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17741405A>G	uc001mni.2	+	1	296	c.76A>G	c.(76-78)ACG>GCG	p.T26A		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	26					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3																		---	---	---	---
ANO3	63982	broad.mit.edu	37	11	26563573	26563573	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:26563573G>A	uc001mqt.3	+	11	1257	c.1112G>A	c.(1111-1113)CGC>CAC	p.R371H	ANO3_uc010rdr.1_Missense_Mutation_p.R355H|ANO3_uc010rds.1_Missense_Mutation_p.R210H|ANO3_uc010rdt.1_Missense_Mutation_p.R225H	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	371	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
ELF5	2001	broad.mit.edu	37	11	34515034	34515034	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34515034C>T	uc001mvo.1	-	3	607	c.377G>A	c.(376-378)CGC>CAC	p.R126H	ELF5_uc001mvp.1_Missense_Mutation_p.R116H|ELF5_uc009ykd.1_Intron|ELF5_uc001mvq.1_Missense_Mutation_p.R116H	NM_198381	NP_938195	Q9UKW6	ELF5_HUMAN	E74-like factor 5 ESE-2a	126	PNT.				cell proliferation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.0087)|all_hematologic(20;0.0384)														OREG0020879	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ACCSL	390110	broad.mit.edu	37	11	44069845	44069845	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:44069845G>A	uc001mxw.1	+	1	315	c.259G>A	c.(259-261)GCG>ACG	p.A87T	ACCSL_uc009ykr.2_5'UTR	NM_001031854	NP_001027025	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase	87							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5																		---	---	---	---
ALX4	60529	broad.mit.edu	37	11	44331611	44331611	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:44331611A>G	uc001myb.2	-	1	106	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	1					hair follicle development						0																		---	---	---	---
SLC35C1	55343	broad.mit.edu	37	11	45832397	45832397	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45832397C>T	uc001nbp.2	+	2	1318	c.606C>T	c.(604-606)GGC>GGT	p.G202G	SLC35C1_uc001nbo.2_Silent_p.G189G|SLC35C1_uc010rgm.1_Silent_p.G189G	NM_018389	NP_060859	Q96A29	FUCT1_HUMAN	GDP-fucose transporter 1 isoform a	202	Helical; (Potential).					Golgi membrane|integral to membrane	GDP-fucose transmembrane transporter activity				0				GBM - Glioblastoma multiforme(35;0.227)														---	---	---	---
MTCH2	23788	broad.mit.edu	37	11	47660521	47660521	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47660521T>C	uc010rho.1	-	2	359	c.170A>G	c.(169-171)TAT>TGT	p.Y57C	MTCH2_uc001nge.2_5'UTR|MTCH2_uc010rhp.1_5'UTR	NM_014342	NP_055157	Q9Y6C9	MTCH2_HUMAN	mitochondrial carrier 2	57	Solcar 1.				transport	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
OR4C15	81309	broad.mit.edu	37	11	55322161	55322161	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55322161T>A	uc010rig.1	+	1	379	c.379T>A	c.(379-381)TCA>ACA	p.S127T		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2															HNSCC(20;0.049)			---	---	---	---
OR5D16	390144	broad.mit.edu	37	11	55606335	55606335	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55606335C>A	uc010rio.1	+	1	108	c.108C>A	c.(106-108)GTC>GTA	p.V36V		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)																---	---	---	---
OR5T2	219464	broad.mit.edu	37	11	56000059	56000059	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56000059A>G	uc010rjc.1	-	1	603	c.603T>C	c.(601-603)GCT>GCC	p.A201A		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	201	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)																	---	---	---	---
PRG2	5553	broad.mit.edu	37	11	57156097	57156097	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57156097C>T	uc001njz.2	-	3	478	c.451G>A	c.(451-453)GCG>ACG	p.A151T	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.A151T|PRG2_uc001nkb.2_Missense_Mutation_p.A151T|PRG2_uc001nkd.2_Missense_Mutation_p.A140T|PRG2_uc001nkc.2_Missense_Mutation_p.A151T|PRG2_uc001nke.2_Missense_Mutation_p.A431T	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	151	C-type lectin.				defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)													---	---	---	---
CTNND1	1500	broad.mit.edu	37	11	57569578	57569578	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57569578A>T	uc001nmc.3	+	7	1901	c.1330A>T	c.(1330-1332)AAG>TAG	p.K444*	CTNND1_uc001nlh.1_Nonsense_Mutation_p.K444*|CTNND1_uc001nlu.3_Nonsense_Mutation_p.K343*|CTNND1_uc001nlt.3_Nonsense_Mutation_p.K343*|CTNND1_uc001nls.3_Nonsense_Mutation_p.K343*|CTNND1_uc001nlw.3_Nonsense_Mutation_p.K343*|CTNND1_uc001nmf.3_Nonsense_Mutation_p.K444*|CTNND1_uc001nmd.3_Nonsense_Mutation_p.K390*|CTNND1_uc001nlk.3_Nonsense_Mutation_p.K390*|CTNND1_uc001nme.3_Nonsense_Mutation_p.K444*|CTNND1_uc001nll.3_Nonsense_Mutation_p.K390*|CTNND1_uc001nmg.3_Nonsense_Mutation_p.K390*|CTNND1_uc001nlj.3_Nonsense_Mutation_p.K390*|CTNND1_uc001nlr.3_Nonsense_Mutation_p.K390*|CTNND1_uc001nlp.3_Nonsense_Mutation_p.K390*|CTNND1_uc001nlx.3_Nonsense_Mutation_p.K121*|CTNND1_uc001nlz.3_Nonsense_Mutation_p.K121*|CTNND1_uc009ymn.2_Nonsense_Mutation_p.K121*|CTNND1_uc001nlm.3_Nonsense_Mutation_p.K444*|CTNND1_uc001nly.3_Nonsense_Mutation_p.K121*|CTNND1_uc001nmb.3_Nonsense_Mutation_p.K121*|CTNND1_uc001nma.3_Nonsense_Mutation_p.K121*|CTNND1_uc001nmi.3_Nonsense_Mutation_p.K343*|CTNND1_uc001nmh.3_Nonsense_Mutation_p.K444*|CTNND1_uc001nlq.3_Nonsense_Mutation_p.K343*|CTNND1_uc001nln.3_Nonsense_Mutation_p.K444*|CTNND1_uc001nli.3_Nonsense_Mutation_p.K444*|CTNND1_uc001nlo.3_Nonsense_Mutation_p.K343*|CTNND1_uc001nlv.3_Nonsense_Mutation_p.K343*	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	444	ARM 3.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)																---	---	---	---
FAM111A	63901	broad.mit.edu	37	11	58920618	58920618	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58920618C>T	uc010rkp.1	+	5	1704	c.1477C>T	c.(1477-1479)CGA>TGA	p.R493*	FAM111A_uc010rkq.1_Nonsense_Mutation_p.R493*|FAM111A_uc010rkr.1_Nonsense_Mutation_p.R493*|FAM111A_uc001nno.2_Nonsense_Mutation_p.R493*|FAM111A_uc001nnp.2_Nonsense_Mutation_p.R493*|FAM111A_uc001nnq.2_Nonsense_Mutation_p.R493*	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	493					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)																---	---	---	---
SLC22A6	9356	broad.mit.edu	37	11	62744860	62744860	+	Splice_Site	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62744860C>A	uc001nwk.2	-	9	1669	c.1362_splice	c.e9-1	p.R454_splice	SLC22A6_uc001nwl.2_Intron|SLC22A6_uc001nwj.2_Splice_Site_p.R454_splice|SLC22A6_uc001nwm.2_Intron	NM_004790	NP_004781			solute carrier family 22 member 6 isoform a						alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0																		---	---	---	---
SLC22A10	387775	broad.mit.edu	37	11	63069976	63069976	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63069976G>A	uc009yor.2	+	7	1454	c.1246G>A	c.(1246-1248)GTG>ATG	p.V416M	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_Intron|SLC22A10_uc010rmp.1_Intron	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	416	Helical; (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2																		---	---	---	---
MARK2	2011	broad.mit.edu	37	11	63670254	63670254	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63670254G>A	uc001nxw.2	+	13	1995	c.1416G>A	c.(1414-1416)ACG>ACA	p.T472T	MARK2_uc001nxx.2_Silent_p.T472T|MARK2_uc001nxy.2_Silent_p.T471T|MARK2_uc001nxv.3_Silent_p.T471T|MARK2_uc001nxz.3_Silent_p.T438T|MARK2_uc009yoy.2_Silent_p.T438T	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	472					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																		---	---	---	---
GPR137	56834	broad.mit.edu	37	11	64055863	64055863	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64055863A>G	uc001nzg.1	+	6	1143	c.835A>G	c.(835-837)ATC>GTC	p.I279V	GPR137_uc010rni.1_Missense_Mutation_p.I337V|GPR137_uc001nzf.2_Missense_Mutation_p.I229V|GPR137_uc001nzi.2_Missense_Mutation_p.I279V|GPR137_uc010rnj.1_Missense_Mutation_p.I279V|KCNK4_uc009ypl.1_5'Flank|KCNK4_uc001nzj.1_5'Flank|KCNK4_uc001nzk.1_5'Flank|KCNK4_uc010rnk.1_5'Flank	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	279	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1																		---	---	---	---
DPP3	10072	broad.mit.edu	37	11	66262922	66262922	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66262922C>T	uc001oig.1	+	14	1601	c.1539C>T	c.(1537-1539)AGC>AGT	p.S513S	DPP3_uc001oif.1_Silent_p.S513S|DPP3_uc010rpe.1_Silent_p.S502S|DPP3_uc001oih.1_5'Flank	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	513					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2																		---	---	---	---
CLCF1	23529	broad.mit.edu	37	11	67133087	67133087	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67133087G>A	uc001okq.2	-	3	394	c.198C>T	c.(196-198)GGC>GGT	p.G66G	LOC100130987_uc010rpo.1_Intron|CLCF1_uc010rpp.1_Silent_p.G56G	NM_013246	NP_037378	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1 precursor	66					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity				0			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)															---	---	---	---
MTL5	9633	broad.mit.edu	37	11	68480770	68480770	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68480770C>A	uc001ooc.2	-	8	1266	c.1126G>T	c.(1126-1128)GGC>TGC	p.G376C		NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	376	CXC 2.				cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)															---	---	---	---
CPT1A	1374	broad.mit.edu	37	11	68574926	68574926	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68574926C>T	uc001oog.3	-						CPT1A_uc001oof.3_Intron|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867			carnitine palmitoyltransferase 1A liver isoform						carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)													---	---	---	---
CTTN	2017	broad.mit.edu	37	11	70277339	70277339	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70277339G>A	uc001opv.3	+	15	1425	c.1219G>A	c.(1219-1221)GCA>ACA	p.A407T	CTTN_uc001opu.2_Missense_Mutation_p.A370T|CTTN_uc001opw.3_Missense_Mutation_p.A370T|CTTN_uc010rqm.1_Missense_Mutation_p.A91T|CTTN_uc001opx.2_Missense_Mutation_p.A91T	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	407						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)														---	---	---	---
DHCR7	1717	broad.mit.edu	37	11	71146556	71146556	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71146556G>C	uc001oqk.2	-	9	1543	c.1293C>G	c.(1291-1293)TTC>TTG	p.F431L	DHCR7_uc001oql.2_Missense_Mutation_p.F431L	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	431	Helical; (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)									Smith-Lemli-Opitz_syndrome				---	---	---	---
KRTAP5-7	440050	broad.mit.edu	37	11	71238367	71238367	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71238367C>T	uc001oqq.1	+	1	55	c.21C>T	c.(19-21)TCC>TCT	p.S7S		NM_001012503	NP_001012521	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	7						keratin filament					0																		---	---	---	---
C11orf51	25906	broad.mit.edu	37	11	71821194	71821194	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71821194C>T	uc001orw.2	-	5	480	c.258G>A	c.(256-258)ATG>ATA	p.M86I	LRTOMT_uc010rqv.1_3'UTR|LRTOMT_uc010rqw.1_3'UTR|LRTOMT_uc001ors.3_3'UTR|C11orf51_uc009ytc.1_Missense_Mutation_p.M77I|C11orf51_uc001orv.2_Missense_Mutation_p.M86I	NM_014042	NP_054761	P60006	CK051_HUMAN	hypothetical protein LOC25906	86	Asp-rich.					intracellular					0																		---	---	---	---
INPPL1	3636	broad.mit.edu	37	11	71939414	71939414	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71939414G>A	uc001osf.2	+	3	416	c.269G>A	c.(268-270)CGC>CAC	p.R90H	INPPL1_uc001osg.2_5'UTR	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	90	SH2.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4																		---	---	---	---
P2RY6	5031	broad.mit.edu	37	11	73008445	73008445	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73008445C>T	uc001otm.2	+	4	1287	c.882C>T	c.(880-882)AGC>AGT	p.S294S	P2RY6_uc001otn.2_Silent_p.S294S|P2RY6_uc001oto.2_Silent_p.S294S|P2RY6_uc001otp.2_Silent_p.S294S|P2RY6_uc001otq.2_Silent_p.S294S|P2RY6_uc001otr.2_Silent_p.S294S|P2RY6_uc001ots.2_Silent_p.S294S	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	294	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1																		---	---	---	---
OMP	4975	broad.mit.edu	37	11	76814096	76814096	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:76814096G>A	uc010rsk.1	+	1	211	c.211G>A	c.(211-213)GTG>ATG	p.V71M	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	71					sensory perception of smell|synaptic transmission						0																		---	---	---	---
RSF1	51773	broad.mit.edu	37	11	77386206	77386206	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77386206C>T	uc001oyn.2	-	14	3557	c.3437G>A	c.(3436-3438)CGT>CAT	p.R1146H	RSF1_uc001oym.2_Missense_Mutation_p.R894H	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1146	Arg-rich.				CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)															---	---	---	---
RSF1	51773	broad.mit.edu	37	11	77389135	77389135	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77389135T>C	uc001oyn.2	-	12	3249	c.3129A>G	c.(3127-3129)GGA>GGG	p.G1043G	RSF1_uc001oym.2_Silent_p.G791G	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1043					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)															---	---	---	---
PCF11	51585	broad.mit.edu	37	11	82877337	82877337	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82877337A>C	uc001ozx.3	+	5	1743	c.1398A>C	c.(1396-1398)AAA>AAC	p.K466N	PCF11_uc010rsu.1_Missense_Mutation_p.K466N	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	466					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1																		---	---	---	---
DLG2	1740	broad.mit.edu	37	11	83874553	83874553	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:83874553A>G	uc001paj.2	-	4	563	c.260T>C	c.(259-261)GTC>GCC	p.V87A	DLG2_uc001pai.2_Missense_Mutation_p.V36A|DLG2_uc010rsy.1_Missense_Mutation_p.V54A|DLG2_uc010rsz.1_Missense_Mutation_p.V87A|DLG2_uc010rta.1_Missense_Mutation_p.V87A|DLG2_uc001pak.2_Missense_Mutation_p.V192A|DLG2_uc010rtb.1_Missense_Mutation_p.V54A|DLG2_uc001pal.1_Missense_Mutation_p.V87A|DLG2_uc001pam.1_Missense_Mutation_p.V126A	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	87						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)																---	---	---	---
FZD4	8322	broad.mit.edu	37	11	86663160	86663160	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:86663160C>T	uc001pce.2	-	2	944	c.638G>A	c.(637-639)CGC>CAC	p.R213H	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	213	Extracellular (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
TRIM49	57093	broad.mit.edu	37	11	89537602	89537602	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89537602T>G	uc001pdb.2	-	3	365	c.36A>C	c.(34-36)GAA>GAC	p.E12D		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	12						intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)																---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92086520	92086520	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92086520T>C	uc001pdj.3	+	1	1259	c.1242T>C	c.(1240-1242)GGT>GGC	p.G414G		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	414	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
DCUN1D5	84259	broad.mit.edu	37	11	102936995	102936995	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102936995T>C	uc001phm.2	-						DCUN1D5_uc010ruw.1_Intron	NM_032299	NP_115675			DCN1, defective in cullin neddylation 1, domain												0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.00032)|Epithelial(105;0.0689)|all cancers(92;0.186)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	103091455	103091455	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103091455T>G	uc001pho.2	+	57	9194	c.9050T>G	c.(9049-9051)CTT>CGT	p.L3017R	DYNC2H1_uc001phn.1_Missense_Mutation_p.L3017R|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3017	Stalk (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
DDI1	414301	broad.mit.edu	37	11	103907607	103907607	+	Silent	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103907607C>G	uc001phr.2	+	1	300	c.57C>G	c.(55-57)CTC>CTG	p.L19L	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	19	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)														---	---	---	---
EXPH5	23086	broad.mit.edu	37	11	108385274	108385274	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108385274C>T	uc001pkk.2	-	6	1071	c.960G>A	c.(958-960)TCG>TCA	p.S320S	EXPH5_uc010rvy.1_Silent_p.S132S|EXPH5_uc010rvz.1_Silent_p.S164S|EXPH5_uc010rwa.1_Silent_p.S244S	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	320					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)														---	---	---	---
DDX10	1662	broad.mit.edu	37	11	108547978	108547978	+	Intron	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108547978C>A	uc001pkm.2	+						DDX10_uc001pkl.1_Intron	NM_004398	NP_004389			DEAD (Asp-Glu-Ala-Asp) box polypeptide 10								ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)				T	NUP98	AML*								---	---	---	---
ARHGAP20	57569	broad.mit.edu	37	11	110494969	110494969	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110494969C>T	uc001pkz.1	-	5	705	c.420G>A	c.(418-420)GTG>GTA	p.V140V	ARHGAP20_uc001pky.1_Silent_p.V117V|ARHGAP20_uc009yyb.1_Silent_p.V104V|ARHGAP20_uc001pla.1_Silent_p.V104V	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	140	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)														---	---	---	---
TTC12	54970	broad.mit.edu	37	11	113187019	113187019	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113187019A>T	uc001pnu.2	+	2	145	c.40A>T	c.(40-42)AAA>TAA	p.K14*	TTC12_uc001pnv.2_Nonsense_Mutation_p.K14*|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_5'UTR	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	14							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)														---	---	---	---
CADM1	23705	broad.mit.edu	37	11	115088652	115088652	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:115088652C>T	uc001ppi.3	-	6	910	c.781G>A	c.(781-783)GAC>AAC	p.D261N	CADM1_uc001ppf.3_Missense_Mutation_p.D261N|CADM1_uc001ppk.3_Missense_Mutation_p.D261N|CADM1_uc001ppj.3_Missense_Mutation_p.D261N|CADM1_uc001ppl.2_Missense_Mutation_p.D261N|CADM1_uc001pph.3_Missense_Mutation_p.D13N	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	261	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)														---	---	---	---
APOA5	116519	broad.mit.edu	37	11	116661524	116661524	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116661524C>G	uc001ppr.2	-	3	429	c.421G>C	c.(421-423)GCC>CCC	p.A141P	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Missense_Mutation_p.A141P|APOA5_uc009yzf.2_Missense_Mutation_p.A141P|APOA5_uc009yzg.2_Missense_Mutation_p.A167P	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	141	Potential.				acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)														---	---	---	---
MLL	4297	broad.mit.edu	37	11	118380738	118380738	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118380738G>T	uc001pta.2	+	30	10990	c.10967G>T	c.(10966-10968)CGG>CTG	p.R3656L	MLL_uc001ptb.2_Missense_Mutation_p.R3659L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3656					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
FOXR1	283150	broad.mit.edu	37	11	118851219	118851219	+	Missense_Mutation	SNP	C	T	T	rs117450447	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118851219C>T	uc001pui.2	+	5	856	c.631C>T	c.(631-633)CGG>TGG	p.R211W	FOXR1_uc001puj.2_Intron|FOXR1_uc001puk.2_Missense_Mutation_p.R42W	NM_181721	NP_859072	Q6PIV2	FOXR1_HUMAN	forkhead box R1	211	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)														---	---	---	---
NLRX1	79671	broad.mit.edu	37	11	119045721	119045721	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119045721G>A	uc001pvu.2	+	6	1624	c.1409G>A	c.(1408-1410)CGT>CAT	p.R470H	NLRX1_uc010rzc.1_Missense_Mutation_p.R292H|NLRX1_uc001pvv.2_Missense_Mutation_p.R470H|NLRX1_uc001pvw.2_Missense_Mutation_p.R470H|NLRX1_uc001pvx.2_Missense_Mutation_p.R470H	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	470	Required for interaction with MAVS.|NACHT.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)														---	---	---	---
TECTA	7007	broad.mit.edu	37	11	120998548	120998548	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120998548G>A	uc010rzo.1	+	8	1862	c.1862G>A	c.(1861-1863)CGG>CAG	p.R621Q		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	621	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
TECTA	7007	broad.mit.edu	37	11	121038922	121038922	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121038922C>T	uc010rzo.1	+	18	5746	c.5746C>T	c.(5746-5748)CTA>TTA	p.L1916L		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1916	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
TECTA	7007	broad.mit.edu	37	11	121060508	121060508	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121060508C>T	uc010rzo.1	+	22	6286	c.6286C>T	c.(6286-6288)CAG>TAG	p.Q2096*		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	2096					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
BSX	390259	broad.mit.edu	37	11	122850169	122850169	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122850169C>T	uc010rzs.1	-							NM_001098169	NP_001091639			brain specific homeobox												0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)														---	---	---	---
OR10G7	390265	broad.mit.edu	37	11	123909507	123909507	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123909507C>A	uc001pzq.1	-	1	202	c.202G>T	c.(202-204)GAC>TAC	p.D68Y		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)														---	---	---	---
OR8B8	26493	broad.mit.edu	37	11	124310278	124310278	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124310278G>T	uc010sal.1	-	1	704	c.704C>A	c.(703-705)TCC>TAC	p.S235Y		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)														---	---	---	---
DDX25	29118	broad.mit.edu	37	11	125792705	125792705	+	Intron	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125792705G>C	uc001qcz.3	+							NM_013264	NP_037396			DEAD (Asp-Glu-Ala-Asp) box polypeptide 25						mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(1)	1	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)												OREG0021479	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ST3GAL4	6484	broad.mit.edu	37	11	126279292	126279292	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:126279292C>T	uc001qds.2	+	9	976	c.757C>T	c.(757-759)CGG>TGG	p.R253W	ST3GAL4_uc001qdt.2_Missense_Mutation_p.R249W|ST3GAL4_uc009zcc.2_Missense_Mutation_p.R89W|ST3GAL4_uc009zcd.2_Missense_Mutation_p.R242W|ST3GAL4_uc001qdu.2_Missense_Mutation_p.R249W|ST3GAL4_uc001qdv.2_Missense_Mutation_p.R253W|ST3GAL4_uc009zce.2_Missense_Mutation_p.R249W|ST3GAL4_uc001qdw.2_Missense_Mutation_p.R242W|ST3GAL4_uc001qdx.1_Missense_Mutation_p.R210W|ST3GAL4_uc001qdy.2_Missense_Mutation_p.R89W|ST3GAL4_uc001qdz.2_Missense_Mutation_p.R89W	NM_006278	NP_006269	Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	253	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)														---	---	---	---
ARHGAP32	9743	broad.mit.edu	37	11	128838937	128838937	+	Silent	SNP	G	A	A	rs144742823		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:128838937G>A	uc009zcp.2	-	22	6129	c.6129C>T	c.(6127-6129)GGC>GGT	p.G2043G	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Silent_p.G1002G|ARHGAP32_uc001qez.2_Silent_p.G1694G	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2043	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5																		---	---	---	---
GLB1L3	112937	broad.mit.edu	37	11	134182389	134182389	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134182389G>A	uc009zdf.2	+						GLB1L3_uc001qho.3_Intron	NM_001080407	NP_001073876			galactosidase, beta 1 like 3						carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)														---	---	---	---
GLB1L2	89944	broad.mit.edu	37	11	134244523	134244523	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134244523A>C	uc001qhp.2	+	18	1923	c.1735A>C	c.(1735-1737)AAT>CAT	p.N579H	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	579					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)														---	---	---	---
ERC1	23085	broad.mit.edu	37	12	1137182	1137182	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1137182C>T	uc001qjb.2	+	2	354	c.113C>T	c.(112-114)ACG>ATG	p.T38M	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.T38M|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.T38M	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	38					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)															---	---	---	---
FOXM1	2305	broad.mit.edu	37	12	2983600	2983600	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2983600C>T	uc001qlf.2	-	2	310	c.45G>A	c.(43-45)AGG>AGA	p.R15R	TULP3_uc010sef.1_5'Flank|FOXM1_uc001qle.2_Silent_p.R15R|FOXM1_uc001qlg.2_Silent_p.R15R|FOXM1_uc009zea.2_Silent_p.R15R|FOXM1_uc009zeb.2_Silent_p.R15R|C12orf32_uc001qlh.2_5'Flank|C12orf32_uc010see.1_5'Flank|C12orf32_uc001qli.2_5'Flank	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	15					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)															---	---	---	---
KCNA1	3736	broad.mit.edu	37	12	5020676	5020676	+	Silent	SNP	C	T	T	rs139476802		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5020676C>T	uc001qnh.2	+	2	1237	c.132C>T	c.(130-132)TCC>TCT	p.S44S		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	44					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
KCNA5	3741	broad.mit.edu	37	12	5153669	5153669	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5153669A>G	uc001qni.2	+	1	585	c.356A>G	c.(355-357)CAC>CGC	p.H119R		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	119						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4																		---	---	---	---
VWF	7450	broad.mit.edu	37	12	6161888	6161888	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6161888G>A	uc001qnn.1	-	16	2257	c.2007C>T	c.(2005-2007)TGC>TGT	p.C669C	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	669	TIL 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)													---	---	---	---
TNFRSF1A	7132	broad.mit.edu	37	12	6439831	6439831	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6439831A>G	uc001qnu.2	-	7	953	c.672T>C	c.(670-672)CTT>CTC	p.L224L	TNFRSF1A_uc001qnt.2_Silent_p.L116L|TNFRSF1A_uc010sey.1_5'UTR|TNFRSF1A_uc010sez.1_Silent_p.L116L|TNFRSF1A_uc009zek.2_Silent_p.L181L	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	224	Helical; (Potential).				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			lung(2)|skin(1)	3																		---	---	---	---
COPS7A	50813	broad.mit.edu	37	12	6837087	6837087	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6837087C>T	uc001qqj.2	+						COPS7A_uc009zex.2_Intron|COPS7A_uc001qqk.2_Intron|COPS7A_uc001qql.2_Intron|COPS7A_uc001qqh.2_Intron|COPS7A_uc001qqi.2_Intron|COPS7A_uc001qqm.2_Intron|COPS7A_uc001qqn.3_Intron|COPS7A_uc001qqo.2_Intron	NM_001164094	NP_001157566			COP9 complex subunit 7a						cullin deneddylation	cytoplasm|signalosome				ovary(1)	1																		---	---	---	---
CLSTN3	9746	broad.mit.edu	37	12	7288865	7288865	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7288865G>A	uc001qsr.2	+	6	1084	c.806G>A	c.(805-807)CGC>CAC	p.R269H	CLSTN3_uc001qss.2_Missense_Mutation_p.R281H	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	269	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1																		---	---	---	---
SLC2A14	144195	broad.mit.edu	37	12	7967113	7967113	+	Silent	SNP	G	A	A	rs146444974	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7967113G>A	uc001qtk.2	-	16	2155	c.1362C>T	c.(1360-1362)TAC>TAT	p.Y454Y	SLC2A14_uc001qtl.2_Silent_p.Y431Y|SLC2A14_uc001qtm.2_Silent_p.Y431Y|SLC2A14_uc010sgg.1_Silent_p.Y345Y|SLC2A14_uc001qtn.2_Silent_p.Y454Y|SLC2A14_uc001qto.2_Silent_p.Y89Y|SLC2A14_uc010sgh.1_Silent_p.Y469Y	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	454	Helical; Name=12; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)														---	---	---	---
PHC1	1911	broad.mit.edu	37	12	9086456	9086456	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9086456T>C	uc001qvd.2	+						PHC1_uc010sgn.1_Intron|PHC1_uc001qve.2_Intron	NM_004426	NP_004417			polyhomeotic 1-like						multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2																		---	---	---	---
A2M	2	broad.mit.edu	37	12	9246106	9246106	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9246106C>T	uc001qvk.1	-	18	2308	c.2195G>A	c.(2194-2196)CGA>CAA	p.R732Q	A2M_uc009zgk.1_Missense_Mutation_p.R582Q	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	732	Inhibitory.				blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)													---	---	---	---
PZP	5858	broad.mit.edu	37	12	9309872	9309872	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9309872A>G	uc001qvl.2	-	28	3478	c.3449T>C	c.(3448-3450)GTC>GCC	p.V1150A	PZP_uc009zgl.2_Missense_Mutation_p.V936A	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5																		---	---	---	---
KLRD1	3824	broad.mit.edu	37	12	10462078	10462078	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10462078T>A	uc001qxw.3	+	3	296	c.99T>A	c.(97-99)AAT>AAA	p.N33K	KLRD1_uc001qxx.3_Missense_Mutation_p.N33K|KLRD1_uc001qxy.3_Intron|KLRD1_uc009zhh.2_Missense_Mutation_p.N33K|KLRD1_uc009zhi.2_Missense_Mutation_p.N33K|KLRD1_uc001qxz.3_Missense_Mutation_p.N33K	NM_001114396	NP_001107868	Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D,	33	Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0																		---	---	---	---
KLRC1	3821	broad.mit.edu	37	12	10603715	10603715	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10603715G>A	uc001qyl.2	-	2	205	c.41C>T	c.(40-42)CCC>CTC	p.P14L	KLRC1_uc009zhm.1_Missense_Mutation_p.P14L|KLRC1_uc001qym.2_Missense_Mutation_p.P14L|KLRC1_uc001qyn.2_Missense_Mutation_p.P14L|KLRC1_uc001qyo.2_Missense_Mutation_p.P14L	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	14	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0																		---	---	---	---
ETV6	2120	broad.mit.edu	37	12	11992235	11992235	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:11992235T>G	uc001qzz.2	+	3	599	c.325T>G	c.(325-327)TCA>GCA	p.S109A		NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	109	PNT.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)						T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								---	---	---	---
MANSC1	54682	broad.mit.edu	37	12	12483888	12483888	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12483888A>G	uc001rai.1	-	4	627	c.369T>C	c.(367-369)TTT>TTC	p.F123F	MANSC1_uc010shm.1_Silent_p.F57F|MANSC1_uc001raj.1_Silent_p.F89F|MANSC1_uc009zht.1_Silent_p.F42F	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	123	Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)														---	---	---	---
DUSP16	80824	broad.mit.edu	37	12	12630143	12630143	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12630143G>A	uc001rao.1	-	7	2254	c.1622C>T	c.(1621-1623)TCG>TTG	p.S541L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.S393L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	541					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)														---	---	---	---
PYROXD1	79912	broad.mit.edu	37	12	21605065	21605065	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21605065C>T	uc001rew.2	+	5	592	c.465C>T	c.(463-465)AAC>AAT	p.N155N	PYROXD1_uc009ziq.2_Intron|PYROXD1_uc009zir.2_Intron	NM_024854	NP_079130	Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase	155							oxidoreductase activity			ovary(1)	1																		---	---	---	---
KCNJ8	3764	broad.mit.edu	37	12	21926557	21926557	+	5'UTR	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21926557G>A	uc001rff.2	-	2						NM_004982	NP_004973			potassium inwardly-rectifying channel J8							voltage-gated potassium channel complex					0					Levosimendan(DB00922)											OREG0021704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ABCC9	10060	broad.mit.edu	37	12	21954066	21954066	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21954066C>T	uc001rfh.2	-	38	4582	c.4562G>A	c.(4561-4563)CGA>CAA	p.R1521Q	ABCC9_uc001rfg.2_Missense_Mutation_p.R50Q	NM_020297	NP_064693	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1521	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)													---	---	---	---
ITPR2	3709	broad.mit.edu	37	12	26572089	26572089	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:26572089G>A	uc001rhg.2	-	50	7420	c.7003C>T	c.(7003-7005)CGT>TGT	p.R2335C	ITPR2_uc009zjg.1_Missense_Mutation_p.R486C	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2335	Extracellular (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)																	---	---	---	---
FAR2	55711	broad.mit.edu	37	12	29469773	29469773	+	Splice_Site	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:29469773G>A	uc001ris.3	+	9	1103	c.956_splice	c.e9-1	p.G319_splice	FAR2_uc001rit.2_Splice_Site_p.G319_splice|FAR2_uc009zjm.2_Splice_Site_p.G222_splice|uc001riu.1_Intron	NM_018099	NP_060569			fatty acyl CoA reductase 2						ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0																		---	---	---	---
PRICKLE1	144165	broad.mit.edu	37	12	42860085	42860085	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:42860085C>A	uc010skv.1	-	6	973	c.686G>T	c.(685-687)AGG>ATG	p.R229M	PRICKLE1_uc001rnl.2_Missense_Mutation_p.R229M|PRICKLE1_uc010skw.1_Missense_Mutation_p.R229M|PRICKLE1_uc001rnm.2_Missense_Mutation_p.R229M	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	229	LIM zinc-binding 2.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)														---	---	---	---
NELL2	4753	broad.mit.edu	37	12	45269328	45269328	+	Intron	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:45269328A>C	uc001rog.2	-						NELL2_uc001rof.3_Missense_Mutation_p.L5R|NELL2_uc001roh.2_Intron|NELL2_uc009zkd.2_Missense_Mutation_p.L5R|NELL2_uc010skz.1_Intron|NELL2_uc010sla.1_Intron|NELL2_uc001roi.1_Intron|NELL2_uc010slb.1_Missense_Mutation_p.L5R|NELL2_uc001roj.2_Intron	NM_001145108	NP_001138580			NEL-like protein 2 isoform b precursor						cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)														---	---	---	---
SLC38A1	81539	broad.mit.edu	37	12	46592455	46592455	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46592455C>T	uc001rpa.2	-	14	1333	c.1075G>A	c.(1075-1077)GCT>ACT	p.A359T	SLC38A1_uc001rpb.2_Missense_Mutation_p.A359T|SLC38A1_uc001rpc.2_Missense_Mutation_p.A359T|SLC38A1_uc001rpd.2_Missense_Mutation_p.A359T|SLC38A1_uc001rpe.2_Missense_Mutation_p.A359T|SLC38A1_uc009zkj.1_Missense_Mutation_p.A359T	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	359	Helical; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)															---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49443676	49443676	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49443676G>A	uc001rta.3	-	11	3695	c.3695C>T	c.(3694-3696)CCG>CTG	p.P1232L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1232					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
TUBA1B	10376	broad.mit.edu	37	12	49523374	49523374	+	Silent	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49523374T>G	uc001rtm.2	-	2	356	c.135A>C	c.(133-135)GGA>GGC	p.G45G	TUBA1B_uc001rto.2_Intron|TUBA1B_uc001rtk.2_Silent_p.G10G|TUBA1B_uc001rtl.2_Silent_p.G10G|TUBA1B_uc001rtn.2_5'UTR	NM_006082	NP_006073	P68363	TBA1B_HUMAN	tubulin, alpha, ubiquitous	45					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding				0																		---	---	---	---
SPATS2	65244	broad.mit.edu	37	12	49893963	49893963	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49893963C>T	uc001rud.2	+	9	1803	c.814C>T	c.(814-816)CAA>TAA	p.Q272*	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Nonsense_Mutation_p.Q272*|SPATS2_uc001ruf.2_Nonsense_Mutation_p.Q272*|SPATS2_uc001rug.2_Nonsense_Mutation_p.Q272*	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	272						cytoplasm				breast(1)	1																		---	---	---	---
BIN2	51411	broad.mit.edu	37	12	51693477	51693477	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51693477G>A	uc001ryg.2	-	6	482	c.430C>T	c.(430-432)CGG>TGG	p.R144W	BIN2_uc009zlz.2_Missense_Mutation_p.R112W|BIN2_uc001ryh.2_Missense_Mutation_p.R20W|BIN2_uc010sng.1_Missense_Mutation_p.R118W	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	144	BAR.					cytoplasm	protein binding			ovary(1)	1																		---	---	---	---
ACVR1B	91	broad.mit.edu	37	12	52369163	52369163	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52369163G>A	uc001rzn.2	+	2	248	c.206G>A	c.(205-207)TGC>TAC	p.C69Y	ACVR1B_uc001rzl.2_Missense_Mutation_p.C69Y|ACVR1B_uc001rzm.2_Missense_Mutation_p.C69Y|ACVR1B_uc010snn.1_Missense_Mutation_p.C69Y	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	69	Extracellular (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)													---	---	---	---
ACVR1B	91	broad.mit.edu	37	12	52387827	52387827	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52387827G>A	uc001rzn.2	+	9	1493	c.1451G>A	c.(1450-1452)CGC>CAC	p.R484H	ACVR1B_uc010snn.1_Missense_Mutation_p.R525H	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	484	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)													---	---	---	---
EIF4B	1975	broad.mit.edu	37	12	53428436	53428436	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53428436C>T	uc001sbh.3	+	10	1455	c.1249C>T	c.(1249-1251)CGG>TGG	p.R417W	EIF4B_uc010snu.1_Missense_Mutation_p.R417W|EIF4B_uc010snv.1_Missense_Mutation_p.R378W|EIF4B_uc001sbi.2_Missense_Mutation_p.R169W	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	417					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2																		---	---	---	---
CALCOCO1	57658	broad.mit.edu	37	12	54108979	54108979	+	Intron	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54108979C>A	uc001sef.2	-						CALCOCO1_uc001see.2_5'Flank|CALCOCO1_uc010som.1_Intron|CALCOCO1_uc010son.1_Intron|CALCOCO1_uc001seh.2_Intron|CALCOCO1_uc009znd.2_Intron|CALCOCO1_uc001seg.2_Intron|CALCOCO1_uc010soo.1_Intron	NM_020898	NP_065949			coiled-coil transcriptional coactivator isoform						steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1																		---	---	---	---
OR6C2	341416	broad.mit.edu	37	12	55846644	55846644	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55846644A>G	uc001sgz.1	+	1	647	c.647A>G	c.(646-648)TAC>TGC	p.Y216C		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	216	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2																		---	---	---	---
GLS2	27165	broad.mit.edu	37	12	56867049	56867049	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56867049C>T	uc001slj.2	-	14	1691	c.1412G>A	c.(1411-1413)CGG>CAG	p.R471Q	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Missense_Mutation_p.R206Q|GLS2_uc009zot.2_Missense_Mutation_p.R132Q	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	471					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)													---	---	---	---
BAZ2A	11176	broad.mit.edu	37	12	56995394	56995394	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56995394G>A	uc001slq.1	-	20	4207	c.4013C>T	c.(4012-4014)CCG>CTG	p.P1338L	BAZ2A_uc001slp.1_Missense_Mutation_p.P1336L|BAZ2A_uc001slo.1_Missense_Mutation_p.P166L|BAZ2A_uc009zov.1_Missense_Mutation_p.P308L|BAZ2A_uc009zow.1_Missense_Mutation_p.P1306L	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1338	Pro-rich.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0																		---	---	---	---
NXPH4	11247	broad.mit.edu	37	12	57619197	57619197	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57619197A>G	uc010srf.1	+	2	769	c.594A>G	c.(592-594)GCA>GCG	p.A198A	NXPH4_uc009zpj.2_Silent_p.A4A	NM_007224	NP_009155	O95158	NXPH4_HUMAN	neurexophilin 4 precursor	198	IV (linker domain).				neuropeptide signaling pathway	extracellular region					0																		---	---	---	---
OS9	10956	broad.mit.edu	37	12	58114052	58114052	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58114052C>T	uc001spj.2	+						OS9_uc010srx.1_Intron|OS9_uc001spk.2_Intron|OS9_uc001spl.2_Intron|OS9_uc001spm.2_Intron|OS9_uc001spn.2_Intron|OS9_uc010sry.1_Intron|OS9_uc010srz.1_Intron	NM_006812	NP_006803			osteosarcoma amplified 9, endoplasmic reticulum						ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)															---	---	---	---
DPY19L2	283417	broad.mit.edu	37	12	64062022	64062022	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64062022G>A	uc001srp.1	-	1	333	c.152C>T	c.(151-153)TCC>TTC	p.S51F	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	51					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)														---	---	---	---
TBK1	29110	broad.mit.edu	37	12	64853958	64853958	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64853958C>T	uc001ssc.1	+							NM_013254	NP_037386			TANK-binding kinase 1						I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|large_intestine(1)|breast(1)	5				GBM - Glioblastoma multiforme(28;0.0386)														---	---	---	---
GRIP1	23426	broad.mit.edu	37	12	66838485	66838485	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66838485G>A	uc001stk.2	-	12	1651	c.1410C>T	c.(1408-1410)GAC>GAT	p.D470D	GRIP1_uc010sta.1_Silent_p.D414D|GRIP1_uc001stj.2_Silent_p.D252D|GRIP1_uc001stl.1_Silent_p.D362D|GRIP1_uc001stm.2_Silent_p.D470D	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	522	PDZ 4.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)														---	---	---	---
NUP107	57122	broad.mit.edu	37	12	69085873	69085873	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69085873G>T	uc001suf.2	+	5	544	c.429G>T	c.(427-429)GAG>GAT	p.E143D	NUP107_uc001sug.2_Intron|NUP107_uc010stj.1_Missense_Mutation_p.E114D	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	143					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)															---	---	---	---
NUP107	57122	broad.mit.edu	37	12	69109462	69109462	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69109462A>G	uc001suf.2	+	12	1140	c.1025A>G	c.(1024-1026)GAT>GGT	p.D342G	NUP107_uc001sug.2_Missense_Mutation_p.D189G|NUP107_uc010stj.1_Missense_Mutation_p.D313G	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	342					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)															---	---	---	---
FRS2	10818	broad.mit.edu	37	12	69967824	69967824	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69967824C>T	uc001suy.2	+	10	1126	c.616C>T	c.(616-618)CGG>TGG	p.R206W	FRS2_uc001suz.2_Missense_Mutation_p.R206W|FRS2_uc009zrj.2_Missense_Mutation_p.R206W|FRS2_uc009zrk.2_Missense_Mutation_p.R206W	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	206					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)															---	---	---	---
CAPS2	84698	broad.mit.edu	37	12	75687145	75687145	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75687145A>G	uc001sxk.3	-	13	1301	c.1104T>C	c.(1102-1104)GGT>GGC	p.G368G	CAPS2_uc001sxm.3_Silent_p.G136G|CAPS2_uc009zsa.2_5'UTR|CAPS2_uc001sxi.3_Silent_p.G104G|CAPS2_uc001sxj.3_Silent_p.G279G|CAPS2_uc001sxl.3_Silent_p.G349G	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	368							calcium ion binding			ovary(2)	2																		---	---	---	---
KRR1	11103	broad.mit.edu	37	12	75900126	75900126	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75900126T>C	uc001sxt.2	-	5	614	c.573A>G	c.(571-573)TCA>TCG	p.S191S	KRR1_uc009zsc.2_Silent_p.S191S|KRR1_uc010stx.1_3'UTR	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	191	KH.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2																		---	---	---	---
SLC6A15	55117	broad.mit.edu	37	12	85277607	85277607	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85277607G>A	uc001szv.2	-						SLC6A15_uc010sul.1_Intron|SLC6A15_uc001szy.2_Silent_p.L263L	NM_182767	NP_877499			solute carrier family 6, member 15 isoform 1						cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3																		---	---	---	---
LRRIQ1	84125	broad.mit.edu	37	12	85466854	85466854	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85466854T>C	uc001tac.2	+	11	2976	c.2865T>C	c.(2863-2865)CTT>CTC	p.L955L	LRRIQ1_uc001tab.1_Silent_p.L955L	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	955										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)														---	---	---	---
KITLG	4254	broad.mit.edu	37	12	88912617	88912617	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88912617C>T	uc001tav.2	-	4	403	c.220G>A	c.(220-222)GTA>ATA	p.V74I	KITLG_uc009zsn.2_Missense_Mutation_p.V2I|KITLG_uc001taw.2_Missense_Mutation_p.V74I|KITLG_uc009zso.1_Intron	NM_000899	NP_000890	P21583	SCF_HUMAN	KIT ligand isoform b precursor	74	Extracellular (Potential).				cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1														Testicular_Cancer_Familial_Clustering_of				---	---	---	---
C12orf48	55010	broad.mit.edu	37	12	102572467	102572467	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102572467C>A	uc001tjf.2	+	8	1215	c.1103C>A	c.(1102-1104)CCT>CAT	p.P368H	C12orf48_uc001tjg.2_Missense_Mutation_p.P287H|C12orf48_uc010swa.1_Missense_Mutation_p.P445H|C12orf48_uc001tjh.2_Missense_Mutation_p.P287H|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Missense_Mutation_p.P83H|C12orf48_uc001tjk.2_Intron|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	368					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0																		---	---	---	---
C12orf42	374470	broad.mit.edu	37	12	103696141	103696141	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:103696141G>A	uc001tjt.2	-	6	916	c.828C>T	c.(826-828)GGC>GGT	p.G276G	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Silent_p.G276G|C12orf42_uc001tju.2_Silent_p.G181G	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	276										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
UBE3B	89910	broad.mit.edu	37	12	109935694	109935694	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109935694C>A	uc001top.2	+	10	1388	c.785C>A	c.(784-786)GCT>GAT	p.A262D	UBE3B_uc001toq.2_Missense_Mutation_p.A262D|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.A262D	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	262					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4																		---	---	---	---
TRPV4	59341	broad.mit.edu	37	12	110226265	110226265	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110226265G>T	uc001tpj.1	-	12	2243	c.2148C>A	c.(2146-2148)GCC>GCA	p.A716A	TRPV4_uc001tpg.1_Silent_p.A682A|TRPV4_uc001tph.1_Silent_p.A669A|TRPV4_uc001tpi.1_Silent_p.A609A|TRPV4_uc001tpk.1_Silent_p.A716A|TRPV4_uc001tpl.1_Silent_p.A656A	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	716	Cytoplasmic (Potential).		A -> S (in SMDK).		actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
ACAD10	80724	broad.mit.edu	37	12	112191598	112191598	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112191598G>T	uc001tsq.2	+	19	3040	c.2840G>T	c.(2839-2841)GGG>GTG	p.G947V	ACAD10_uc009zvx.2_Missense_Mutation_p.G978V|ACAD10_uc001tss.1_Intron	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	947							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2																OREG0022130	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
C12orf51	283450	broad.mit.edu	37	12	112691953	112691953	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112691953G>A	uc009zwc.2	-	15	2063	c.2045C>T	c.(2044-2046)GCG>GTG	p.A682V	C12orf51_uc010syk.1_Missense_Mutation_p.A514V|C12orf51_uc001tts.2_Missense_Mutation_p.A505V|C12orf51_uc001ttt.3_Missense_Mutation_p.A503V	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2																		---	---	---	---
RBM19	9904	broad.mit.edu	37	12	114397939	114397939	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:114397939G>A	uc009zwi.2	-	3	408	c.264C>T	c.(262-264)GCC>GCT	p.A88A	RBM19_uc001tvn.3_Silent_p.A88A|RBM19_uc001tvm.2_Silent_p.A88A	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	88					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)																	---	---	---	---
HNF1A	6927	broad.mit.edu	37	12	121426811	121426811	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121426811C>T	uc001tzg.2	+	2	525	c.502C>T	c.(502-504)CGC>TGC	p.R168C	HNF1A_uc001tze.1_Missense_Mutation_p.R168C|HNF1A_uc001tzf.2_Missense_Mutation_p.R168C|HNF1A_uc010szn.1_Missense_Mutation_p.R168C	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	168					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding	p.R168C(1)		liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)													Hepatic_Adenoma_Familial_Clustering_of				---	---	---	---
DHX37	57647	broad.mit.edu	37	12	125434766	125434766	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:125434766C>T	uc001ugy.2	-	24	3244	c.3145G>A	c.(3145-3147)GCC>ACC	p.A1049T	DHX37_uc001ugz.1_Missense_Mutation_p.A136T	NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	1049							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)														---	---	---	---
SLC15A4	121260	broad.mit.edu	37	12	129283815	129283815	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:129283815T>C	uc001uhu.2	-	7	1615	c.1562A>G	c.(1561-1563)CAC>CGC	p.H521R	SLC15A4_uc001uhv.2_RNA	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	521					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)														---	---	---	---
TMEM132D	121256	broad.mit.edu	37	12	129559044	129559044	+	Silent	SNP	C	A	A	rs143332531	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:129559044C>A	uc009zyl.1	-	9	3004	c.2676G>T	c.(2674-2676)GTG>GTT	p.V892V	TMEM132D_uc001uia.2_Silent_p.V430V	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	892	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)														---	---	---	---
TMEM132D	121256	broad.mit.edu	37	12	130184741	130184741	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130184741G>A	uc009zyl.1	-	2	910	c.582C>T	c.(580-582)GCC>GCT	p.A194A		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	194	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)														---	---	---	---
FZD10	11211	broad.mit.edu	37	12	130647661	130647661	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130647661C>G	uc001uii.2	+	1	630	c.174C>G	c.(172-174)CAC>CAG	p.H58Q	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	58	FZ.|Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)														---	---	---	---
ZNF10	7556	broad.mit.edu	37	12	133732657	133732657	+	Silent	SNP	C	T	T	rs11147260		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133732657C>T	uc009zzb.2	+	5	1272	c.825C>T	c.(823-825)AGC>AGT	p.S275S	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Silent_p.S275S	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	275	C2H2-type 2.			Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)														---	---	---	---
PARP4	143	broad.mit.edu	37	13	25030523	25030523	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25030523G>A	uc001upl.2	-	21	2624	c.2518C>T	c.(2518-2520)CTC>TTC	p.L840F	PARP4_uc010tdc.1_Missense_Mutation_p.L840F	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	840					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)														---	---	---	---
RNF17	56163	broad.mit.edu	37	13	25376644	25376644	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25376644G>A	uc001upr.2	+	14	1925	c.1884G>A	c.(1882-1884)CCG>CCA	p.P628P	RNF17_uc010tdd.1_Silent_p.P487P|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Silent_p.P628P|RNF17_uc001ups.2_Silent_p.P567P	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	628					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)														---	---	---	---
PAN3	255967	broad.mit.edu	37	13	28841270	28841270	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28841270G>A	uc001urz.2	+	10	1182	c.1174G>A	c.(1174-1176)GAC>AAC	p.D392N	PAN3_uc010tdo.1_Missense_Mutation_p.D538N|PAN3_uc001ury.2_Missense_Mutation_p.D226N|PAN3_uc001urx.2_Missense_Mutation_p.D338N	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	538	Protein kinase.|Interaction with PAN2.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)														---	---	---	---
FLT1	2321	broad.mit.edu	37	13	29001439	29001439	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:29001439G>A	uc001usb.3	-	10	1578	c.1293C>T	c.(1291-1293)TAC>TAT	p.Y431Y	FLT1_uc010aar.1_Silent_p.Y431Y|FLT1_uc001usc.3_Silent_p.Y431Y|FLT1_uc010tdp.1_Silent_p.Y431Y	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	431	Ig-like C2-type 5.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)													---	---	---	---
SLC46A3	283537	broad.mit.edu	37	13	29286870	29286870	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:29286870A>C	uc001usi.2	-	2	1977	c.1007T>G	c.(1006-1008)ATG>AGG	p.M336R	SLC46A3_uc001usg.2_Missense_Mutation_p.M261R|SLC46A3_uc001usj.2_Missense_Mutation_p.M336R|SLC46A3_uc001ush.2_Missense_Mutation_p.M336R|SLC46A3_uc001usk.2_Missense_Mutation_p.M261R	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	336	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)														---	---	---	---
UBL3	5412	broad.mit.edu	37	13	30341767	30341767	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:30341767G>C	uc001usp.2	-	4	1434	c.289C>G	c.(289-291)CCA>GCA	p.P97A		NM_007106	NP_009037	O95164	UBL3_HUMAN	ubiquitin-like 3 precursor	97						intracellular|plasma membrane					0		Lung SC(185;0.0281)		all cancers(112;0.0598)|GBM - Glioblastoma multiforme(144;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.147)														---	---	---	---
C13orf26	122046	broad.mit.edu	37	13	31506851	31506851	+	5'UTR	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:31506851G>A	uc001uti.2	+	1					uc001utg.1_5'Flank	NM_152325	NP_689538			hypothetical protein LOC122046											ovary(2)|skin(1)	3		Lung SC(185;0.0281)		all cancers(112;0.0176)|Epithelial(112;0.0768)|OV - Ovarian serous cystadenocarcinoma(117;0.0852)														---	---	---	---
FRY	10129	broad.mit.edu	37	13	32753081	32753081	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32753081C>T	uc001utx.2	+	22	3278	c.2782C>T	c.(2782-2784)CCC>TCC	p.P928S	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	928					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
FRY	10129	broad.mit.edu	37	13	32821607	32821607	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32821607A>G	uc001utx.2	+	48	7472	c.6976A>G	c.(6976-6978)AAA>GAA	p.K2326E	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
FRY	10129	broad.mit.edu	37	13	32850638	32850638	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32850638G>A	uc001utx.2	+	57	8820	c.8324G>A	c.(8323-8325)AGT>AAT	p.S2775N	FRY_uc010tdw.1_RNA|FRY_uc001uty.2_Missense_Mutation_p.S330N|FRY_uc001utz.2_Missense_Mutation_p.S300N|FRY_uc010tdx.1_Missense_Mutation_p.S145N	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2775					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
BRCA2	675	broad.mit.edu	37	13	32929044	32929044	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32929044C>T	uc001uub.1	+	14	7281	c.7054C>T	c.(7054-7056)CCT>TCT	p.P2352S		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2352	Interaction with FANCD2.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)				D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			---	---	---	---
N4BP2L2	10443	broad.mit.edu	37	13	33012780	33012780	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33012780C>T	uc010abe.1	-						N4BP2L2_uc001uug.2_Intron|N4BP2L2_uc010abd.1_Intron|N4BP2L2_uc001uuh.2_Intron|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Intron	NM_033111	NP_149102			phosphonoformate immuno-associated protein 5												0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)														---	---	---	---
NBEA	26960	broad.mit.edu	37	13	35517239	35517239	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:35517239G>A	uc001uvb.2	+	2	488	c.282G>A	c.(280-282)ACG>ACA	p.T94T		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	94						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
FREM2	341640	broad.mit.edu	37	13	39424294	39424294	+	Missense_Mutation	SNP	C	T	T	rs114837786	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:39424294C>T	uc001uwv.2	+	9	6808	c.6499C>T	c.(6499-6501)CGG>TGG	p.R2167W	FREM2_uc001uww.2_Missense_Mutation_p.R253W	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2167	Extracellular (Potential).|Calx-beta 4.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)														---	---	---	---
MRPS31	10240	broad.mit.edu	37	13	41323298	41323298	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41323298C>A	uc001uxm.3	-	6	1009	c.934G>T	c.(934-936)GAG>TAG	p.E312*		NM_005830	NP_005821	Q92665	RT31_HUMAN	mitochondrial ribosomal protein S31 precursor	312						mitochondrion|ribosome	protein domain specific binding				0		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)														---	---	---	---
KIAA0564	23078	broad.mit.edu	37	13	42273343	42273343	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42273343A>G	uc001uyj.2	-	29	3498	c.3428T>C	c.(3427-3429)ATG>ACG	p.M1143T		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1143						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)														---	---	---	---
EPSTI1	94240	broad.mit.edu	37	13	43543269	43543269	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:43543269T>A	uc001uyw.1	-	3	368	c.292A>T	c.(292-294)AAC>TAC	p.N98Y	EPSTI1_uc001uyx.1_Missense_Mutation_p.N98Y	NM_001002264	NP_001002264	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 isoform 1	98	Potential.									ovary(1)	1		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)														---	---	---	---
ENOX1	55068	broad.mit.edu	37	13	43900600	43900600	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:43900600C>T	uc001uza.3	-	10	1398	c.1098G>A	c.(1096-1098)TCG>TCA	p.S366S	ENOX1_uc001uzb.3_Silent_p.S366S|ENOX1_uc001uzc.3_Silent_p.S366S|ENOX1_uc001uyz.3_Intron|ENOX1_uc010tfm.1_Silent_p.S179S	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	366					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)														---	---	---	---
SIAH3	283514	broad.mit.edu	37	13	46425655	46425655	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46425655A>G	uc001vap.2	-	1	192	c.110T>C	c.(109-111)GTC>GCC	p.V37A		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	37					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2																		---	---	---	---
C13orf18	80183	broad.mit.edu	37	13	46937325	46937325	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46937325G>A	uc010acl.2	-	6	1455	c.850C>T	c.(850-852)CCA>TCA	p.P284S	C13orf18_uc001vbf.3_Missense_Mutation_p.P217S|C13orf18_uc001vbg.3_Missense_Mutation_p.P12S|C13orf18_uc010tfz.1_Missense_Mutation_p.P127S|C13orf18_uc010acm.2_Missense_Mutation_p.P149S|C13orf18_uc010acn.2_Missense_Mutation_p.P69S|C13orf18_uc001vbe.3_Missense_Mutation_p.P284S|C13orf18_uc001vbh.3_Missense_Mutation_p.P284S|C13orf18_uc001vbi.3_Missense_Mutation_p.P127S|C13orf18_uc010aco.1_Missense_Mutation_p.P284S	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	284											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)														---	---	---	---
LRCH1	23143	broad.mit.edu	37	13	47315978	47315978	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:47315978G>A	uc001vbj.2	+	19	2418	c.2182G>A	c.(2182-2184)GCA>ACA	p.A728T	LRCH1_uc001vbk.2_Missense_Mutation_p.A763T|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	728										ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)														---	---	---	---
ATP7B	540	broad.mit.edu	37	13	52532477	52532477	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52532477G>A	uc001vfw.2	-	8	2482	c.2325C>T	c.(2323-2325)GCC>GCT	p.A775A	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Intron|ATP7B_uc001vfy.2_Silent_p.A664A|ATP7B_uc010tgt.1_Silent_p.A775A|ATP7B_uc010tgu.1_Silent_p.A727A|ATP7B_uc010tgv.1_Intron|ATP7B_uc001vfv.2_Silent_p.A47A|ATP7B_uc010tgs.1_Silent_p.A47A|ATP7B_uc010tgw.1_3'UTR	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	775	Helical; (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)										Wilson_disease				---	---	---	---
THSD1	55901	broad.mit.edu	37	13	52971858	52971858	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52971858T>C	uc001vgo.2	-	3	1075	c.530A>G	c.(529-531)GAG>GGG	p.E177G	THSD1_uc001vgp.2_Missense_Mutation_p.E177G|THSD1_uc010tgz.1_Intron|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	177	Extracellular (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)														---	---	---	---
PCDH8	5100	broad.mit.edu	37	13	53418924	53418924	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53418924C>T	uc001vhi.2	-	3	3187	c.2984G>A	c.(2983-2985)CGG>CAG	p.R995Q	PCDH8_uc001vhj.2_Missense_Mutation_p.R898Q	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	995	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)														---	---	---	---
PCDH17	27253	broad.mit.edu	37	13	58206890	58206890	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:58206890C>A	uc001vhq.1	+	1	1102	c.210C>A	c.(208-210)TCC>TCA	p.S70S	PCDH17_uc010aec.1_Silent_p.S70S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	70	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)														---	---	---	---
PCDH17	27253	broad.mit.edu	37	13	58208123	58208123	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:58208123G>A	uc001vhq.1	+	1	2335	c.1443G>A	c.(1441-1443)GTG>GTA	p.V481V	PCDH17_uc010aec.1_Silent_p.V481V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	481	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)														---	---	---	---
DIAPH3	81624	broad.mit.edu	37	13	60565331	60565331	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:60565331A>C	uc001vht.2	-	12	1541	c.1322T>G	c.(1321-1323)CTT>CGT	p.L441R	DIAPH3_uc001vhu.2_Missense_Mutation_p.L178R|DIAPH3_uc001vhv.2_Missense_Mutation_p.L19R	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	441	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)														---	---	---	---
DACH1	1602	broad.mit.edu	37	13	72134083	72134083	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:72134083C>T	uc010thn.1	-	6	1727	c.1304G>A	c.(1303-1305)CGT>CAT	p.R435H	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	487					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)														---	---	---	---
LMO7	4008	broad.mit.edu	37	13	76378450	76378450	+	5'UTR	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:76378450A>G	uc001vjv.2	+	5					LMO7_uc010thv.1_Silent_p.E281E|LMO7_uc001vjt.1_Silent_p.E229E|LMO7_uc010thw.1_Silent_p.E190E|LMO7_uc001vjw.1_5'UTR|LMO7_uc001vju.1_RNA	NM_015842	NP_056667			LIM domain only 7 isoform 2							cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)														---	---	---	---
SLITRK1	114798	broad.mit.edu	37	13	84454827	84454827	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:84454827C>T	uc001vlk.2	-	1	1702	c.816G>A	c.(814-816)CCG>CCA	p.P272P		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	272	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)														---	---	---	---
SLITRK5	26050	broad.mit.edu	37	13	88327712	88327712	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:88327712G>A	uc001vln.2	+	2	288	c.69G>A	c.(67-69)CTG>CTA	p.L23L	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	23						integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)																	---	---	---	---
TGDS	23483	broad.mit.edu	37	13	95244550	95244550	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95244550G>A	uc001vlw.2	-	3	288	c.167C>T	c.(166-168)GCA>GTA	p.A56V	TGDS_uc001vlx.2_RNA	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	56					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)																	---	---	---	---
CLDN10	9071	broad.mit.edu	37	13	96086251	96086251	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96086251C>T	uc001vmg.2	+	1	399	c.164C>T	c.(163-165)GCG>GTG	p.A55V	CLDN10_uc010tii.1_Intron	NM_182848	NP_878268	P78369	CLD10_HUMAN	claudin 10 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)															---	---	---	---
CLDN10	9071	broad.mit.edu	37	13	96205116	96205116	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96205116G>A	uc001vmh.2	+	1	170	c.109G>A	c.(109-111)GGC>AGC	p.G37S	CLDN10_uc001vmg.2_Intron|CLDN10_uc010tii.1_Intron	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	37	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)															---	---	---	---
RNF113B	140432	broad.mit.edu	37	13	98829457	98829457	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:98829457C>T	uc001vnk.2	-	1	65	c.34G>A	c.(34-36)GAC>AAC	p.D12N	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	12							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)															---	---	---	---
STK24	8428	broad.mit.edu	37	13	99109475	99109475	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99109475C>T	uc001vnm.1	-	10	1477	c.1242G>A	c.(1240-1242)GCG>GCA	p.A414A	STK24_uc001vnn.1_Silent_p.A402A|STK24_uc010tim.1_Silent_p.A383A	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	414					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity	p.A414V(1)		ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)															---	---	---	---
SLC15A1	6564	broad.mit.edu	37	13	99354751	99354751	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99354751T>C	uc001vno.2	-	18	1526	c.1449A>G	c.(1447-1449)AAA>AAG	p.K483K		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	483	Extracellular (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)													---	---	---	---
NALCN	259232	broad.mit.edu	37	13	101759837	101759837	+	Splice_Site	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101759837C>T	uc001vox.1	-	22	2768	c.2579_splice	c.e22+1	p.A860_splice		NM_052867	NP_443099			voltage gated channel like 1							integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
NALCN	259232	broad.mit.edu	37	13	101833537	101833537	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101833537T>C	uc001vox.1	-						NALCN_uc001voy.2_Intron|NALCN_uc001voz.2_Missense_Mutation_p.Q639R|NALCN_uc001vpa.2_Missense_Mutation_p.Q639R	NM_052867	NP_443099			voltage gated channel like 1							integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
KDELC1	79070	broad.mit.edu	37	13	103449310	103449310	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103449310G>T	uc001vpq.3	-	2	616	c.232C>A	c.(232-234)CCA>ACA	p.P78T	KDELC1_uc001vpr.3_5'UTR|BIVM_uc001vps.2_5'Flank|BIVM_uc010agc.2_5'Flank	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	78	Filamin.					endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)																	---	---	---	---
MYO16	23026	broad.mit.edu	37	13	109779715	109779715	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:109779715G>A	uc001vqt.1	+	31	3928	c.3802G>A	c.(3802-3804)GTT>ATT	p.V1268I	MYO16_uc010agk.1_Missense_Mutation_p.V1290I|MYO16_uc010tjh.1_Missense_Mutation_p.V780I	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1268					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)															---	---	---	---
MYO16	23026	broad.mit.edu	37	13	109792726	109792726	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:109792726C>T	uc001vqt.1	+	32	4226	c.4100C>T	c.(4099-4101)TCG>TTG	p.S1367L	MYO16_uc010agk.1_Missense_Mutation_p.S1389L	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1367					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)															---	---	---	---
OR4Q3	441669	broad.mit.edu	37	14	20216007	20216007	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20216007C>T	uc010tkt.1	+	1	421	c.421C>T	c.(421-423)CTA>TTA	p.L141L		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)														---	---	---	---
RNASE6	6039	broad.mit.edu	37	14	21250106	21250106	+	Missense_Mutation	SNP	T	G	G	rs139946247		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21250106T>G	uc001vye.3	+	2	541	c.248T>G	c.(247-249)ATT>AGT	p.I83S		NM_005615	NP_005606	Q93091	RNAS6_HUMAN	ribonuclease, RNase A family, k6 precursor	83					defense response|RNA catabolic process	extracellular region	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00406)		Epithelial(56;9.21e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0126)														---	---	---	---
ZNF219	51222	broad.mit.edu	37	14	21559656	21559656	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21559656C>T	uc001vzr.2	-	4	1899	c.1478G>A	c.(1477-1479)CGG>CAG	p.R493Q	ZNF219_uc001vzs.2_Missense_Mutation_p.R493Q|ZNF219_uc010aik.1_Missense_Mutation_p.R493Q	NM_016423	NP_057507	Q9P2Y4	ZN219_HUMAN	zinc finger protein 219	493					negative regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|histamine receptor activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;9.86e-11)|Epithelial(56;1.27e-08)|all cancers(55;6.06e-08)	GBM - Glioblastoma multiforme(265;0.0191)														---	---	---	---
CHD8	57680	broad.mit.edu	37	14	21860061	21860061	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21860061C>T	uc001was.1	-	35	6073	c.5979G>A	c.(5977-5979)GCG>GCA	p.A1993A	CHD8_uc001war.1_Silent_p.A1889A	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2272					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22134239	22134239	+	IGR	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22134239T>C								OR4E2 (3 upstream) : DAD1 (899568 downstream)																																			---	---	---	---
AP1G2	8906	broad.mit.edu	37	14	24033019	24033019	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24033019G>A	uc001wkl.2	-	12	1475	c.1138C>T	c.(1138-1140)CGA>TGA	p.R380*	AP1G2_uc001wkj.2_5'UTR|AP1G2_uc001wkk.3_Nonsense_Mutation_p.R308*|AP1G2_uc001wkn.2_5'UTR|uc001wko.1_Intron|AP1G2_uc001wkp.1_RNA|AP1G2_uc010tnp.1_Nonsense_Mutation_p.R380*	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	380					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)														---	---	---	---
RABGGTA	5875	broad.mit.edu	37	14	24737768	24737768	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24737768C>T	uc001wof.2	-	9	1380	c.958G>A	c.(958-960)GTC>ATC	p.V320I	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Missense_Mutation_p.V320I|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	320					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)														---	---	---	---
ARHGAP5	394	broad.mit.edu	37	14	32562687	32562687	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:32562687G>T	uc001wrl.2	+	2	3051	c.2812G>T	c.(2812-2814)GTT>TTT	p.V938F	ARHGAP5_uc001wrm.2_Missense_Mutation_p.V938F|ARHGAP5_uc001wrn.2_Missense_Mutation_p.V938F|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	938					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)														---	---	---	---
BAZ1A	11177	broad.mit.edu	37	14	35222777	35222777	+	Silent	SNP	G	A	A	rs114946696	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:35222777G>A	uc001wsk.2	-	27	5176	c.4608C>T	c.(4606-4608)CAC>CAT	p.H1536H	BAZ1A_uc001wsl.2_Silent_p.H1504H	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1536					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)														---	---	---	---
MIA2	117153	broad.mit.edu	37	14	39716693	39716693	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39716693A>G	uc001wux.2	+	4	1109	c.915A>G	c.(913-915)CAA>CAG	p.Q305Q	MIA2_uc010amy.1_Silent_p.Q236Q	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	305						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)														---	---	---	---
CDKL1	8814	broad.mit.edu	37	14	50824783	50824783	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50824783C>A	uc010anu.1	-	15	2185	c.2185G>T	c.(2185-2187)GGA>TGA	p.G729*	CDKL1_uc001wxz.2_Intron	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)																	---	---	---	---
PTGDR	5729	broad.mit.edu	37	14	52734770	52734770	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52734770A>G	uc001wzq.2	+	1	340	c.238A>G	c.(238-240)AGC>GGC	p.S80G		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	80	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)													---	---	---	---
FERMT2	10979	broad.mit.edu	37	14	53386022	53386022	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53386022A>G	uc001xad.2	-	3	265	c.210T>C	c.(208-210)ACT>ACC	p.T70T	FERMT2_uc001xac.2_Silent_p.T70T|FERMT2_uc001xae.2_Silent_p.T70T|FERMT2_uc001xaf.2_Silent_p.T70T	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	70					actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)																	---	---	---	---
CGRRF1	10668	broad.mit.edu	37	14	54996827	54996827	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54996827G>T	uc001xay.2	+	3	396	c.305G>T	c.(304-306)TGC>TTC	p.C102F	CGRRF1_uc010tra.1_Missense_Mutation_p.C102F|CGRRF1_uc001xaz.2_RNA	NM_006568	NP_006559	Q99675	CGRF1_HUMAN	cell growth regulator with ring finger domain 1	102					cell cycle arrest|negative regulation of cell proliferation|response to stress		zinc ion binding			ovary(1)	1																		---	---	---	---
SOCS4	122809	broad.mit.edu	37	14	55510009	55510009	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55510009C>T	uc001xbo.2	+	3	815	c.250C>T	c.(250-252)CAT>TAT	p.H84Y	SOCS4_uc001xbp.2_Missense_Mutation_p.H84Y	NM_199421	NP_955453	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	84					intracellular signal transduction|negative regulation of signal transduction|regulation of growth					ovary(1)|kidney(1)	2																		---	---	---	---
GPR135	64582	broad.mit.edu	37	14	59930738	59930738	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:59930738C>T	uc010apj.2	-	1	1322	c.1207G>A	c.(1207-1209)GAG>AAG	p.E403K	GPR135_uc001xed.2_RNA	NM_022571	NP_072093	Q8IZ08	GP135_HUMAN	G protein-coupled receptor 135	403	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.134)														---	---	---	---
GPR135	64582	broad.mit.edu	37	14	59930945	59930945	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:59930945G>T	uc010apj.2	-	1	1115	c.1000C>A	c.(1000-1002)CTC>ATC	p.L334I	GPR135_uc001xed.2_RNA	NM_022571	NP_072093	Q8IZ08	GP135_HUMAN	G protein-coupled receptor 135	334	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.134)														---	---	---	---
C14orf135	64430	broad.mit.edu	37	14	60582161	60582161	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60582161C>T	uc001xer.3	+	3	1159	c.637C>T	c.(637-639)CGG>TGG	p.R213W	C14orf135_uc001xeq.2_Missense_Mutation_p.R213W|C14orf135_uc010apm.2_5'Flank	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	447						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)														---	---	---	---
KCNH5	27133	broad.mit.edu	37	14	63269270	63269270	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:63269270T>C	uc001xfx.2	-	9	1650	c.1599A>G	c.(1597-1599)AGA>AGG	p.R533R	KCNH5_uc001xfy.2_Silent_p.R533R|KCNH5_uc001xfz.1_Silent_p.R475R	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	533	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)														---	---	---	---
SYNE2	23224	broad.mit.edu	37	14	64681174	64681174	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64681174A>G	uc001xgm.2	+	106	19549	c.19319A>G	c.(19318-19320)TAC>TGC	p.Y6440C	SYNE2_uc001xgl.2_Missense_Mutation_p.Y6440C|SYNE2_uc010apy.2_Missense_Mutation_p.Y2825C|SYNE2_uc001xgn.2_Missense_Mutation_p.Y1402C|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.Y410C|SYNE2_uc001xgq.2_Missense_Mutation_p.Y805C|SYNE2_uc001xgr.2_Missense_Mutation_p.Y223C|SYNE2_uc010tsi.1_Missense_Mutation_p.Y74C|SYNE2_uc001xgs.2_Missense_Mutation_p.Y74C|SYNE2_uc001xgt.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6440	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)														---	---	---	---
ESR2	2100	broad.mit.edu	37	14	64701681	64701681	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64701681C>T	uc001xha.1	-						ESR2_uc001xgu.2_Intron|ESR2_uc001xgv.2_Intron|ESR2_uc001xgw.2_Intron|ESR2_uc001xgx.2_Intron|ESR2_uc001xgy.1_Intron|ESR2_uc001xgz.1_Silent_p.A471A|ESR2_uc010aqb.1_Intron|ESR2_uc010aqc.1_Intron	NM_001437	NP_001428			estrogen receptor beta isoform 1						cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)													---	---	---	---
ESR2	2100	broad.mit.edu	37	14	64724058	64724058	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64724058T>C	uc001xha.1	-	6	1445	c.977A>G	c.(976-978)GAC>GGC	p.D326G	ESR2_uc001xgu.2_Missense_Mutation_p.D326G|ESR2_uc001xgv.2_Missense_Mutation_p.D326G|ESR2_uc001xgw.2_Intron|ESR2_uc001xgx.2_Missense_Mutation_p.D326G|ESR2_uc001xgy.1_Missense_Mutation_p.D326G|ESR2_uc001xgz.1_Missense_Mutation_p.D326G|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Intron|ESR2_uc010aqd.1_RNA	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	326	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)													---	---	---	---
SPTB	6710	broad.mit.edu	37	14	65234410	65234410	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65234410G>A	uc001xht.2	-	29	6244	c.6190C>T	c.(6190-6192)CGC>TGC	p.R2064C	SPTB_uc001xhr.2_Missense_Mutation_p.R2064C|SPTB_uc001xhs.2_Missense_Mutation_p.R2064C|SPTB_uc001xhu.2_Missense_Mutation_p.R2064C|SPTB_uc010aqi.2_Missense_Mutation_p.R725C	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2064	Spectrin 17.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)														---	---	---	---
PLEKHH1	57475	broad.mit.edu	37	14	68050703	68050703	+	Intron	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68050703C>A	uc001xjl.1	+						PLEKHH1_uc010tsw.1_Intron|PLEKHH1_uc001xjn.1_Intron|PLEKHH1_uc010tsx.1_Intron|PLEKHH1_uc001xjo.1_Intron|PLEKHH1_uc001xjp.1_Intron	NM_020715	NP_065766			pleckstrin homology domain containing, family H							cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)												OREG0022749	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SLC8A3	6547	broad.mit.edu	37	14	70634344	70634344	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:70634344G>A	uc001xly.2	-	2	1550	c.796C>T	c.(796-798)CGC>TGC	p.R266C	SLC8A3_uc001xlw.2_Missense_Mutation_p.R266C|SLC8A3_uc001xlx.2_Missense_Mutation_p.R266C|SLC8A3_uc001xlz.2_Missense_Mutation_p.R266C|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	266	Calmodulin-binding (By similarity).|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)														---	---	---	---
PSEN1	5663	broad.mit.edu	37	14	73637541	73637541	+	Missense_Mutation	SNP	C	T	T	rs140189461		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73637541C>T	uc001xnr.2	+	4	408	c.124C>T	c.(124-126)CGG>TGG	p.R42W	PSEN1_uc001xnv.2_Missense_Mutation_p.R38W|PSEN1_uc010ark.2_Missense_Mutation_p.R38W|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA|PSEN1_uc001xnq.3_Missense_Mutation_p.R42W	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	42	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)														---	---	---	---
HEATR4	399671	broad.mit.edu	37	14	73964917	73964917	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73964917G>A	uc010tub.1	-	14	2810	c.2488C>T	c.(2488-2490)CGG>TGG	p.R830W	HEATR4_uc010tua.1_Missense_Mutation_p.R783W	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)														---	---	---	---
BATF	10538	broad.mit.edu	37	14	76012887	76012887	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76012887C>T	uc001xrr.2	+	3	493	c.251C>T	c.(250-252)TCG>TTG	p.S84L		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	84						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)														---	---	---	---
STON2	85439	broad.mit.edu	37	14	81744923	81744923	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81744923T>C	uc010tvu.1	-	4	933	c.732A>G	c.(730-732)TTA>TTG	p.L244L	STON2_uc001xvk.1_Silent_p.L244L|STON2_uc010tvt.1_Silent_p.L41L	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	244					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)														---	---	---	---
ATXN3	4287	broad.mit.edu	37	14	92548751	92548751	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92548751T>C	uc001yac.3	-	8	737	c.668A>G	c.(667-669)GAC>GGC	p.D223G	ATXN3_uc010aug.2_Missense_Mutation_p.D208G|ATXN3_uc001yad.3_Missense_Mutation_p.D168G|ATXN3_uc010auh.2_Missense_Mutation_p.D157G|ATXN3_uc001yae.3_Missense_Mutation_p.D125G|ATXN3_uc010twl.1_RNA	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	223					cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)														---	---	---	---
DDX24	57062	broad.mit.edu	37	14	94528520	94528520	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94528520A>C	uc001ycj.2	-	3	1265	c.1166T>G	c.(1165-1167)CTT>CGT	p.L389R	DDX24_uc010twq.1_Missense_Mutation_p.L346R|DDX24_uc010twr.1_Missense_Mutation_p.L139R	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	389	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)														---	---	---	---
SERPINA11	256394	broad.mit.edu	37	14	94912669	94912669	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94912669T>C	uc001ydd.1	-	3	976	c.916A>G	c.(916-918)AGT>GGT	p.S306G		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	306					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)														---	---	---	---
PAPOLA	10914	broad.mit.edu	37	14	97026977	97026977	+	Intron	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:97026977T>A	uc001yfq.2	+						PAPOLA_uc001yfr.2_Intron|PAPOLA_uc010twv.1_Intron|PAPOLA_uc010avp.2_Intron	NM_032632	NP_116021			poly(A) polymerase alpha						mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)														---	---	---	---
BEGAIN	57596	broad.mit.edu	37	14	101004887	101004887	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101004887G>A	uc010txa.1	-	6	1347	c.1201C>T	c.(1201-1203)CGG>TGG	p.R401W	BEGAIN_uc001yhp.2_Missense_Mutation_p.R337W|BEGAIN_uc001yhq.2_Missense_Mutation_p.R401W	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	401						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)																---	---	---	---
HSP90AA1	3320	broad.mit.edu	37	14	102549646	102549646	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102549646T>C	uc001yku.3	-						HSP90AA1_uc001ykv.3_Intron|HSP90AA1_uc001ykw.1_Intron|HSP90AA1_uc001ykx.1_Intron	NM_005348	NP_005339			heat shock 90kDa protein 1, alpha isoform 2						axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)													---	---	---	---
HSP90AA1	3320	broad.mit.edu	37	14	102568317	102568317	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102568317G>A	uc001ykv.3	-	2	606	c.261C>T	c.(259-261)CAC>CAT	p.H87H		NM_001017963	NP_001017963	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 1	Error:Variant_position_missing_in_P07900_after_alignment					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)													---	---	---	---
AMN	81693	broad.mit.edu	37	14	103390157	103390157	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103390157G>A	uc001ymg.3	+	2	186	c.153G>A	c.(151-153)CCG>CCA	p.P51P	AMN_uc001ymh.3_5'UTR	NM_030943	NP_112205	Q9BXJ7	AMNLS_HUMAN	amnionless protein precursor	51	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|multicellular organismal development	integral to membrane|plasma membrane					0				Colorectal(3;0.00739)|READ - Rectum adenocarcinoma(2;0.0336)|Epithelial(152;0.0363)|all cancers(159;0.147)	Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
MARK3	4140	broad.mit.edu	37	14	103958244	103958244	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103958244C>T	uc001ymz.3	+	15	2383	c.1717C>T	c.(1717-1719)CGA>TGA	p.R573*	MARK3_uc001ymx.3_Nonsense_Mutation_p.R573*|MARK3_uc001ymw.3_Nonsense_Mutation_p.R573*|MARK3_uc001yna.3_Nonsense_Mutation_p.R557*|MARK3_uc001ymy.3_Nonsense_Mutation_p.R494*|MARK3_uc010awp.2_Nonsense_Mutation_p.R596*|MARK3_uc010tyb.1_Nonsense_Mutation_p.R368*|MARK3_uc010awq.2_Nonsense_Mutation_p.R155*	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	573							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)															---	---	---	---
TMEM121	80757	broad.mit.edu	37	14	105995256	105995256	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105995256C>A	uc001yrp.1	+	2	236	c.85C>A	c.(85-87)CTG>ATG	p.L29M	ADAM6_uc010tyt.1_Intron|uc001yrr.2_5'Flank	NM_025268	NP_079544	Q9BTD3	TM121_HUMAN	hole protein	29	Helical; (Potential).					integral to membrane					0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.0959)|all cancers(159;0.235)														---	---	---	---
NDN	4692	broad.mit.edu	37	15	23931631	23931631	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23931631A>G	uc001ywk.2	-	1	820	c.734T>C	c.(733-735)CTG>CCG	p.L245P		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	245	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)										Prader-Willi_syndrome				---	---	---	---
SNORD116-4	100033416	broad.mit.edu	37	15	25324236	25324236	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25324236T>C	uc001yxh.1	+						SNORD116-4_uc001yxm.1_Intron|IPW_uc001yxn.3_Intron|SNORD116-13_uc001yxw.2_RNA|SNORD116-14_uc001yxx.2_5'Flank|SNORD116-28_uc001yxy.2_5'Flank|SNORD116-15_uc001yxz.2_5'Flank					Homo sapiens clone kid4 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28443796	28443796	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28443796C>T	uc001zbj.2	-	49	7942	c.7836G>A	c.(7834-7836)CAG>CAA	p.Q2612Q	HERC2_uc001zbk.1_Silent_p.Q147Q	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2612					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28501010	28501010	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28501010A>G	uc001zbj.2	-						HERC2_uc001zbl.1_Intron	NM_004667	NP_004658			hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
MTMR15	22909	broad.mit.edu	37	15	31197145	31197145	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31197145C>A	uc001zff.2	+	2	570	c.279C>A	c.(277-279)ACC>ACA	p.T93T	MTMR15_uc001zfc.3_Silent_p.T93T|MTMR15_uc010azw.2_Silent_p.T93T|MTMR15_uc001zfd.3_Silent_p.T93T|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	93					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)									Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
RYR3	6263	broad.mit.edu	37	15	34130387	34130387	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34130387T>C	uc001zhi.2	+	89	12276	c.12206T>C	c.(12205-12207)ATT>ACT	p.I4069T	RYR3_uc010bar.2_Missense_Mutation_p.I4064T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4069					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
AQR	9716	broad.mit.edu	37	15	35167043	35167043	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35167043C>T	uc001ziv.2	-	29	3441	c.3260G>A	c.(3259-3261)CGA>CAA	p.R1087Q		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	1087						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)														---	---	---	---
BUB1B	701	broad.mit.edu	37	15	40488752	40488752	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40488752A>G	uc001zkx.3	+	9	1277	c.1065A>G	c.(1063-1065)CCA>CCG	p.P355P	BUB1B_uc010ucl.1_Silent_p.P218P	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	355					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)				Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
TYRO3	7301	broad.mit.edu	37	15	41865886	41865886	+	Missense_Mutation	SNP	G	A	A	rs67202013		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41865886G>A	uc001zof.1	+	18	2379	c.2155G>A	c.(2155-2157)GGG>AGG	p.G719R		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	719	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)														---	---	---	---
TYRO3	7301	broad.mit.edu	37	15	41870287	41870287	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41870287G>A	uc001zof.1	+	19	2710	c.2486G>A	c.(2485-2487)AGT>AAT	p.S829N		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	829	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)														---	---	---	---
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42133713	42133713	+	Splice_Site	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42133713A>C	uc010bco.2	+	7	537	c.436_splice	c.e7-2	p.A146_splice	JMJD7-PLA2G4B_uc001zoo.3_Splice_Site_p.A377_splice|JMJD7-PLA2G4B_uc010bcn.2_Splice_Site_p.A377_splice|JMJD7-PLA2G4B_uc001zoq.3_Splice_Site|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105			phospholipase A2, group IVB						arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1																		---	---	---	---
SPTBN5	51332	broad.mit.edu	37	15	42178429	42178429	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42178429G>A	uc001zos.2	-	7	1252	c.919C>T	c.(919-921)CGG>TGG	p.R307W		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	342	Spectrin 1.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)														---	---	---	---
TGM5	9333	broad.mit.edu	37	15	43531260	43531260	+	Intron	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43531260G>T	uc001zrd.1	-						TGM5_uc001zrc.1_Intron|TGM5_uc001zre.1_Intron	NM_201631	NP_963925			transglutaminase 5 isoform 1						epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)													---	---	---	---
SLC24A5	283652	broad.mit.edu	37	15	48428959	48428959	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48428959A>G	uc001zwe.2	+	6	743	c.670A>G	c.(670-672)ATT>GTT	p.I224V	SLC24A5_uc010bel.2_Missense_Mutation_p.I164V|uc001zwf.1_RNA	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	224	Cytoplasmic (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)														---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49044577	49044577	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49044577G>T	uc001zwy.2	-	21	3469	c.3435C>A	c.(3433-3435)CCC>CCA	p.P1145P	CEP152_uc001zwz.2_Silent_p.P1145P|CEP152_uc001zxa.1_Silent_p.P1052P	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1145					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49048345	49048345	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49048345G>A	uc001zwy.2	-	20	3134	c.3100C>T	c.(3100-3102)CGG>TGG	p.R1034W	CEP152_uc001zwz.2_Missense_Mutation_p.R1034W|CEP152_uc001zxa.1_Missense_Mutation_p.R941W	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1034					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49048347	49048347	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49048347T>C	uc001zwy.2	-	20	3132	c.3098A>G	c.(3097-3099)AAG>AGG	p.K1033R	CEP152_uc001zwz.2_Missense_Mutation_p.K1033R|CEP152_uc001zxa.1_Missense_Mutation_p.K940R	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1033					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
CYP19A1	1588	broad.mit.edu	37	15	51504611	51504611	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51504611T>C	uc001zyz.3	-	10	1420	c.1169A>G	c.(1168-1170)AAG>AGG	p.K390R	CYP19A1_uc001zza.3_Missense_Mutation_p.K390R|CYP19A1_uc001zzb.2_Missense_Mutation_p.K390R	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	390					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)													---	---	---	---
DMXL2	23312	broad.mit.edu	37	15	51829690	51829690	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51829690C>G	uc002abf.2	-	11	1837	c.1612G>C	c.(1612-1614)GTT>CTT	p.V538L	DMXL2_uc010ufy.1_Missense_Mutation_p.V538L|DMXL2_uc010bfa.2_Missense_Mutation_p.V538L	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	538						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)														---	---	---	---
SNX1	6642	broad.mit.edu	37	15	64424090	64424090	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64424090G>A	uc002amv.2	+	11	1256	c.1220G>A	c.(1219-1221)CGC>CAC	p.R407H	SNX1_uc010bgv.2_Missense_Mutation_p.R121H|SNX1_uc010uio.1_Missense_Mutation_p.R407H|SNX1_uc002amw.2_Missense_Mutation_p.R407H|SNX1_uc002amx.2_Missense_Mutation_p.R342H|SNX1_uc002amy.2_Missense_Mutation_p.R336H|SNX1_uc010bgw.2_Missense_Mutation_p.R309H	NM_003099	NP_003090	Q13596	SNX1_HUMAN	sorting nexin 1 isoform a	407	BAR.				cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity				0																		---	---	---	---
TRIP4	9325	broad.mit.edu	37	15	64689965	64689965	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64689965G>A	uc002anm.2	+	4	609	c.566G>A	c.(565-567)CGC>CAC	p.R189H		NM_016213	NP_057297	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	189					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
IGDCC3	9543	broad.mit.edu	37	15	65623874	65623874	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65623874G>A	uc002aos.2	-	8	1524	c.1272C>T	c.(1270-1272)CCC>CCT	p.P424P	IGDCC3_uc002aor.1_5'Flank	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	424	Extracellular (Potential).|Fibronectin type-III 1.									ovary(3)	3																		---	---	---	---
IGDCC4	57722	broad.mit.edu	37	15	65685872	65685872	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65685872G>A	uc002aou.1	-						IGDCC4_uc002aot.1_Intron	NM_020962	NP_066013			immunoglobulin superfamily, DCC subclass, member							integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
SMAD6	4091	broad.mit.edu	37	15	67073679	67073679	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:67073679G>A	uc002aqf.2	+	4	2220	c.1297G>A	c.(1297-1299)GGC>AGC	p.G433S	SMAD6_uc010bhx.2_RNA|SMAD6_uc002aqg.2_Missense_Mutation_p.G172S	NM_005585	NP_005576	O43541	SMAD6_HUMAN	SMAD family member 6 isoform 1	433	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			skin(1)	1																		---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72338102	72338102	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72338102A>G	uc002atl.3	-	2	1276	c.803T>C	c.(802-804)GTA>GCA	p.V268A	MYO9A_uc010biq.2_Intron|MYO9A_uc002ato.2_Missense_Mutation_p.V268A|MYO9A_uc002atn.1_Missense_Mutation_p.V268A	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	268	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
LMAN1L	79748	broad.mit.edu	37	15	75105194	75105194	+	5'UTR	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75105194C>T	uc002ayt.1	+	1					LMAN1L_uc010bkd.2_Translation_Start_Site|LMAN1L_uc010ulo.1_Translation_Start_Site|LMAN1L_uc010bke.1_5'UTR	NM_021819	NP_068591			lectin, mannose-binding, 1 like precursor							ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0																		---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75705355	75705355	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75705355A>G	uc002bai.2	-	5	764	c.505T>C	c.(505-507)TCC>CCC	p.S169P	SIN3A_uc002baj.2_Missense_Mutation_p.S169P|SIN3A_uc010uml.1_Missense_Mutation_p.S169P	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	169	Interaction with HCFC1.|PAH 1.				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
SNX33	257364	broad.mit.edu	37	15	75942332	75942332	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75942332C>T	uc002bau.2	+	1	985	c.889C>T	c.(889-891)CGC>TGC	p.R297C	IMP3_uc002bat.2_5'Flank|SNX33_uc002bav.2_5'UTR	NM_153271	NP_695003	Q8WV41	SNX33_HUMAN	sorting nexin 33	297	PX.				cell communication		phosphatidylinositol binding|protein binding			ovary(1)	1																		---	---	---	---
CSPG4	1464	broad.mit.edu	37	15	75979930	75979930	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75979930C>T	uc002baw.2	-	3	3569	c.3476G>A	c.(3475-3477)CGC>CAC	p.R1159H		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1159	Interaction with COL5A1 (By similarity).|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|CSPG 7.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3																		---	---	---	---
CSPG4	1464	broad.mit.edu	37	15	75981453	75981453	+	Silent	SNP	C	G	G	rs77773913	byFrequency;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75981453C>G	uc002baw.2	-	3	2046	c.1953G>C	c.(1951-1953)CCG>CCC	p.P651P		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	651	Interaction with COL5A1 (By similarity).|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3																		---	---	---	---
CSPG4	1464	broad.mit.edu	37	15	75981580	75981580	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75981580G>T	uc002baw.2	-	3	1919	c.1826C>A	c.(1825-1827)CCT>CAT	p.P609H		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	609	Extracellular (Potential).|CSPG 2.|Globular or compact configuration stabilized by disulfide bonds.|Interaction with COL6A2 (By similarity).|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3																		---	---	---	---
AGBL1	123624	broad.mit.edu	37	15	86940602	86940602	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86940602C>T	uc002blz.1	+	17	2322	c.2242C>T	c.(2242-2244)CGT>TGT	p.R748C		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	748					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0																		---	---	---	---
LRRK1	79705	broad.mit.edu	37	15	101562123	101562123	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101562123C>A	uc002bwr.2	+	14	2132	c.1813C>A	c.(1813-1815)CTG>ATG	p.L605M	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	605	LRR 13.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
LRRK1	79705	broad.mit.edu	37	15	101593607	101593607	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101593607C>T	uc002bwr.2	+	26	4355	c.4036C>T	c.(4036-4038)CTG>TTG	p.L1346L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1346	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
LUC7L	55692	broad.mit.edu	37	16	240580	240580	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:240580G>A	uc002cgc.1	-						LUC7L_uc002cga.1_Intron|LUC7L_uc002cgd.1_Intron|LUC7L_uc002cge.1_Intron|LUC7L_uc002cgb.1_Intron	NM_201412	NP_958815			LUC7-like isoform b								metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)																---	---	---	---
PDIA2	64714	broad.mit.edu	37	16	336905	336905	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:336905C>A	uc002cgn.1	+	15	2601	c.1493C>A	c.(1492-1494)CCC>CAC	p.P498H	PDIA2_uc010bqt.1_Missense_Mutation_p.P343H|PDIA2_uc002cgo.1_Missense_Mutation_p.P498H	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	498					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)																---	---	---	---
MSLNL	401827	broad.mit.edu	37	16	824999	824999	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:824999A>G	uc002cjz.1	-	7	1573	c.1573T>C	c.(1573-1575)TCC>CCC	p.S525P		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	174	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4																		---	---	---	---
MAPK8IP3	23162	broad.mit.edu	37	16	1817604	1817604	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1817604C>T	uc002cmk.2	+	27	3394	c.3274C>T	c.(3274-3276)CGG>TGG	p.R1092W	MAPK8IP3_uc002cml.2_Missense_Mutation_p.R1086W|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.R1093W	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	1092					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
PKD1	5310	broad.mit.edu	37	16	2165629	2165629	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2165629G>A	uc002cos.1	-						PKD1_uc002cot.1_Intron	NM_001009944	NP_001009944			polycystin 1 isoform 1 precursor						calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3																		---	---	---	---
CCNF	899	broad.mit.edu	37	16	2489817	2489817	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2489817G>T	uc002cqd.1	+	8	855	c.767G>T	c.(766-768)TGG>TTG	p.W256L	CCNF_uc002cqe.1_5'UTR	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	256					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)																---	---	---	---
PRSS27	83886	broad.mit.edu	37	16	2764172	2764172	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2764172C>T	uc002crf.2	-	4	793	c.402G>A	c.(400-402)GTG>GTA	p.V134V	PRSS27_uc002cre.2_Silent_p.V98V|PRSS27_uc002crg.2_Silent_p.V32V|PRSS27_uc010bst.1_Silent_p.V32V	NM_031948	NP_114154	Q9BQR3	PRS27_HUMAN	marapsin precursor	134	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
ZSCAN10	84891	broad.mit.edu	37	16	3139475	3139475	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3139475G>A	uc002ctv.1	-	5	1883	c.1795C>T	c.(1795-1797)CGC>TGC	p.R599C	ZSCAN10_uc002cty.1_Missense_Mutation_p.R260C|ZSCAN10_uc002ctw.1_Missense_Mutation_p.R517C|ZSCAN10_uc002ctx.1_Missense_Mutation_p.R527C	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	599	C2H2-type 10.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
MEFV	4210	broad.mit.edu	37	16	3306386	3306386	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3306386G>A	uc002cun.1	-	1	242	c.202C>T	c.(202-204)CAG>TAG	p.Q68*		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	68	DAPIN.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)													---	---	---	---
NLRC3	197358	broad.mit.edu	37	16	3614549	3614549	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3614549G>T	uc010btn.2	-	5	800	c.389C>A	c.(388-390)CCT>CAT	p.P130H		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	130					I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
USP7	7874	broad.mit.edu	37	16	8995029	8995029	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:8995029G>A	uc002czl.2	-	19	2309	c.2110C>T	c.(2110-2112)CAT>TAT	p.H704Y	USP7_uc010uyk.1_Missense_Mutation_p.H605Y|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.H605Y|USP7_uc002czk.2_Missense_Mutation_p.H688Y	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	704	Interaction with ICP0/VMW110.				interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3																		---	---	---	---
GRIN2A	2903	broad.mit.edu	37	16	10031878	10031878	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:10031878C>A	uc002czo.3	-	3	1493	c.945G>T	c.(943-945)GAG>GAT	p.E315D	GRIN2A_uc010uym.1_Missense_Mutation_p.E315D|GRIN2A_uc010uyn.1_Missense_Mutation_p.E158D|GRIN2A_uc002czr.3_Missense_Mutation_p.E315D	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	315	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)													---	---	---	---
ERCC4	2072	broad.mit.edu	37	16	14041518	14041518	+	Missense_Mutation	SNP	C	T	T	rs149364215		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14041518C>T	uc002dce.2	+	11	2074	c.2065C>T	c.(2065-2067)CGT>TGT	p.R689C	ERCC4_uc010uyz.1_Missense_Mutation_p.R239C	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	689	ERCC4.|Interaction with EME1 and ERCC1.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10								Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				---	---	---	---
SMG1	23049	broad.mit.edu	37	16	18875096	18875096	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18875096A>G	uc002dfm.2	-	25	3934	c.3571T>C	c.(3571-3573)TGT>CGT	p.C1191R	SMG1_uc010bwb.2_Missense_Mutation_p.C1051R	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1191	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16																		---	---	---	---
COQ7	10229	broad.mit.edu	37	16	19083251	19083251	+	Silent	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19083251T>G	uc002dfr.2	+	2	135	c.75T>G	c.(73-75)GCT>GCG	p.A25A	COQ7_uc002dfs.2_Silent_p.A11A	NM_016138	NP_057222	Q99807	COQ7_HUMAN	COQ7 protein	25					ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			skin(1)	1																OREG0023656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TMC5	79838	broad.mit.edu	37	16	19485561	19485561	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19485561G>A	uc002dgc.3	+	12	2802	c.2053G>A	c.(2053-2055)GAG>AAG	p.E685K	TMC5_uc010vaq.1_Missense_Mutation_p.E633K|TMC5_uc002dgb.3_Missense_Mutation_p.E685K|TMC5_uc010var.1_Missense_Mutation_p.E685K|TMC5_uc002dgd.1_Missense_Mutation_p.E439K|TMC5_uc002dge.3_Missense_Mutation_p.E439K|TMC5_uc002dgf.3_Missense_Mutation_p.E368K|TMC5_uc002dgg.3_Missense_Mutation_p.E326K	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	685	Cytoplasmic (Potential).					integral to membrane				skin(1)	1																		---	---	---	---
EEF2K	29904	broad.mit.edu	37	16	22268599	22268599	+	Missense_Mutation	SNP	G	A	A	rs143471765		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:22268599G>A	uc002dki.2	+	8	1279	c.794G>A	c.(793-795)CGT>CAT	p.R265H	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	265	Alpha-type protein kinase.				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)														---	---	---	---
EEF2K	29904	broad.mit.edu	37	16	22291646	22291646	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:22291646G>A	uc002dki.2	+	17	2502	c.2017G>A	c.(2017-2019)GAG>AAG	p.E673K	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	673					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)														---	---	---	---
CLN3	1201	broad.mit.edu	37	16	28488922	28488922	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28488922G>A	uc002dpo.2	-	15	1555	c.1232C>T	c.(1231-1233)GCC>GTC	p.A411V	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.A333V|CLN3_uc010vcu.1_Missense_Mutation_p.A311V|CLN3_uc002dpn.2_Missense_Mutation_p.A312V|CLN3_uc002dpm.2_Missense_Mutation_p.A357V|CLN3_uc010vcv.1_Missense_Mutation_p.A387V|CLN3_uc010byd.2_Missense_Mutation_p.A314V|CLN3_uc002dpp.2_Missense_Mutation_p.A411V|CLN3_uc002dpt.1_Missense_Mutation_p.A311V|CLN3_uc002dpq.1_Missense_Mutation_p.A363V|CLN3_uc010bye.1_Missense_Mutation_p.A394V|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.A284V|CLN3_uc002dpu.1_Missense_Mutation_p.A309V	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	411	Helical; (Potential).				amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0																		---	---	---	---
HSD3B7	80270	broad.mit.edu	37	16	30999155	30999155	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30999155G>A	uc002eaf.2	+	7	867	c.761G>A	c.(760-762)GGC>GAC	p.G254D	HSD3B7_uc010cac.2_3'UTR|HSD3B7_uc002eag.2_3'UTR|HSD3B7_uc002eah.2_Missense_Mutation_p.G254D	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	254					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0																		---	---	---	---
ZNF668	79759	broad.mit.edu	37	16	31075373	31075373	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31075373G>A	uc010caf.2	-	2	765	c.408C>T	c.(406-408)GGC>GGT	p.G136G	ZNF668_uc002eao.2_Silent_p.G136G|ZNF668_uc010cag.1_Silent_p.G136G	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4																		---	---	---	---
FUS	2521	broad.mit.edu	37	16	31196420	31196420	+	Silent	SNP	C	T	T	rs151073460	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31196420C>T	uc002ebf.2	+	6	767	c.684C>T	c.(682-684)GGC>GGT	p.G228G	FUS_uc002ebe.1_Silent_p.G224G|FUS_uc002ebh.2_Silent_p.G227G|FUS_uc002ebg.2_Missense_Mutation_p.A35V|FUS_uc002ebi.2_Silent_p.G228G|FUS_uc002ebj.2_Missense_Mutation_p.A35V|FUS_uc002ebk.1_5'Flank	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	228	Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)				T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								---	---	---	---
HEATR3	55027	broad.mit.edu	37	16	50112651	50112651	+	Splice_Site	SNP	G	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50112651G>C	uc002efw.2	+	7	926	c.764_splice	c.e7-1	p.G255_splice	HEATR3_uc002efx.2_Splice_Site_p.G169_splice	NM_182922	NP_891552			HEAT repeat containing 3								binding			ovary(1)|skin(1)	2																		---	---	---	---
CYLD	1540	broad.mit.edu	37	16	50828350	50828350	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50828350C>T	uc002egp.1	+						CYLD_uc010cbs.1_Intron|CYLD_uc002egq.1_Intron|CYLD_uc002egr.1_Intron	NM_015247	NP_056062			ubiquitin carboxyl-terminal hydrolase CYLD						cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)						Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				---	---	---	---
RPGRIP1L	23322	broad.mit.edu	37	16	53675003	53675003	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53675003C>T	uc002ehp.2	-	19	2964	c.2900G>A	c.(2899-2901)CGT>CAT	p.R967H	RPGRIP1L_uc002eho.3_Missense_Mutation_p.R967H|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.R967H|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.R967H|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.R967H	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	967					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)																---	---	---	---
SLC12A3	6559	broad.mit.edu	37	16	56920857	56920857	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56920857A>G	uc010ccm.2	+						SLC12A3_uc002ekd.3_Intron|SLC12A3_uc010ccn.2_Intron	NM_001126108	NP_001119580			solute carrier family 12, member 3 isoform 3						sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)													---	---	---	---
CCDC135	84229	broad.mit.edu	37	16	57760089	57760089	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57760089G>A	uc002emi.2	+	13	1957	c.1868G>A	c.(1867-1869)CGT>CAT	p.R623H	CCDC135_uc002emj.2_Missense_Mutation_p.R623H|CCDC135_uc002emk.2_Missense_Mutation_p.R558H	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	623						cytoplasm				central_nervous_system(1)	1																		---	---	---	---
CNGB1	1258	broad.mit.edu	37	16	57931726	57931726	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57931726T>G	uc002emt.2	-	30	3134	c.3069A>C	c.(3067-3069)AAA>AAC	p.K1023N	CNGB1_uc010cdh.2_Missense_Mutation_p.K1017N	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1023	Cytoplasmic (Potential).|cAMP (By similarity).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4																		---	---	---	---
PRSS54	221191	broad.mit.edu	37	16	58314157	58314157	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58314157C>T	uc002enf.2	-	7	1554	c.1159G>A	c.(1159-1161)GTG>ATG	p.V387M	PRSS54_uc002eng.2_Missense_Mutation_p.V387M|PRSS54_uc010vie.1_Missense_Mutation_p.V288M|CCDC113_uc002ene.2_3'UTR|CCDC113_uc010vid.1_3'UTR	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	387					proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
PRSS54	221191	broad.mit.edu	37	16	58324906	58324906	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58324906T>A	uc002enf.2	-	4	615	c.220A>T	c.(220-222)AGC>TGC	p.S74C	PRSS54_uc002eng.2_Missense_Mutation_p.S74C|PRSS54_uc010vie.1_Intron	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	74	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
CDH8	1006	broad.mit.edu	37	16	61747823	61747823	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:61747823T>G	uc002eog.1	-	10	1828	c.1576A>C	c.(1576-1578)AAA>CAA	p.K526Q		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	526	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)														---	---	---	---
TK2	7084	broad.mit.edu	37	16	66551046	66551046	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66551046A>G	uc002eos.2	-	8	962	c.737T>C	c.(736-738)ATT>ACT	p.I246T	TK2_uc010vip.1_Missense_Mutation_p.I107T|TK2_uc002eor.2_Missense_Mutation_p.I173T|TK2_uc010cdq.2_Intron|TK2_uc010cdr.2_Missense_Mutation_p.I155T|TK2_uc010viq.1_Missense_Mutation_p.I228T|TK2_uc010vir.1_Missense_Mutation_p.I221T	NM_004614	NP_004605	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial	204					pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)												OREG0032067	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	---	---	---	---
CMTM1	113540	broad.mit.edu	37	16	66612846	66612846	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66612846C>T	uc002epi.3	+	4	575	c.452C>T	c.(451-453)TCC>TTC	p.S151F	CMTM1_uc002epb.3_RNA|CMTM1_uc002epc.3_RNA|CMTM1_uc002epd.3_RNA|CMTM1_uc002epe.3_RNA|CMTM1_uc002epf.3_RNA|CMTM1_uc002epg.3_RNA|CMTM1_uc002eph.3_3'UTR|CMTM1_uc002epl.3_Missense_Mutation_p.S104F|CMTM1_uc002epj.3_3'UTR|CMTM1_uc002epk.3_Missense_Mutation_p.S98F|CMTM1_uc002epa.3_3'UTR|CMTM1_uc002epn.3_3'UTR|CMTM1_uc002epo.3_RNA|CMTM1_uc002epp.3_RNA|CMTM1_uc002epq.3_RNA|CMTM1_uc010cds.2_RNA|CMTM1_uc002epr.3_Missense_Mutation_p.S268F|CMTM1_uc002epm.3_RNA|CMTM1_uc002eps.2_RNA|CMTM2_uc002ept.2_5'Flank|CMTM2_uc010cdu.2_5'Flank	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1	151					chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)														---	---	---	---
FHOD1	29109	broad.mit.edu	37	16	67270917	67270917	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67270917C>T	uc002esl.2	-	10	1206	c.1094G>A	c.(1093-1095)CGC>CAC	p.R365H	FHOD1_uc010ced.2_Missense_Mutation_p.R172H|FHOD1_uc010vjh.1_Missense_Mutation_p.A28T	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	365	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)														---	---	---	---
FAM65A	79567	broad.mit.edu	37	16	67576836	67576836	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67576836A>G	uc010vjp.1	+	13	2303	c.2207A>G	c.(2206-2208)CAG>CGG	p.Q736R	FAM65A_uc010cei.1_Missense_Mutation_p.Q558R|FAM65A_uc002eth.2_Missense_Mutation_p.Q716R|FAM65A_uc010cej.2_Missense_Mutation_p.Q719R|FAM65A_uc002eti.1_Missense_Mutation_p.Q679R|FAM65A_uc010vjq.1_Missense_Mutation_p.Q730R|FAM65A_uc002etj.1_Missense_Mutation_p.Q715R|FAM65A_uc002etk.2_Missense_Mutation_p.Q715R	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	720	Pro-rich.					cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)														---	---	---	---
SMPD3	55512	broad.mit.edu	37	16	68406042	68406042	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68406042C>T	uc002ewa.2	-	3	465	c.43G>A	c.(43-45)GCC>ACC	p.A15T	SMPD3_uc010cfe.2_Missense_Mutation_p.A15T|SMPD3_uc010vlh.1_Missense_Mutation_p.A15T	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	15	Helical; (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)													---	---	---	---
ZFP90	146198	broad.mit.edu	37	16	68597623	68597623	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68597623G>A	uc010cff.2	+	5	1225	c.933G>A	c.(931-933)CAG>CAA	p.Q311Q	ZFP90_uc002ewb.2_Missense_Mutation_p.S117N|ZFP90_uc002ewc.2_Missense_Mutation_p.S117N|ZFP90_uc002ewd.2_Silent_p.Q311Q|ZFP90_uc002ewe.2_Silent_p.Q311Q	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	311	C2H2-type 4.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)														---	---	---	---
ZFP90	146198	broad.mit.edu	37	16	68598358	68598358	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68598358T>C	uc010cff.2	+	5	1960	c.1668T>C	c.(1666-1668)ATT>ATC	p.I556I	ZFP90_uc002ewb.2_3'UTR|ZFP90_uc002ewc.2_3'UTR|ZFP90_uc002ewd.2_Silent_p.I556I|ZFP90_uc002ewe.2_Silent_p.I556I	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	556	C2H2-type 11.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)														---	---	---	---
PDPR	55066	broad.mit.edu	37	16	70166194	70166194	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70166194G>A	uc002eyf.1	+	9	1945	c.988G>A	c.(988-990)GAT>AAT	p.D330N	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.D230N|PDPR_uc002eyg.1_Missense_Mutation_p.D58N	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	330					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)														---	---	---	---
HYDIN	54768	broad.mit.edu	37	16	70993674	70993674	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70993674C>A	uc002ezr.2	-	39	6143	c.6015G>T	c.(6013-6015)GAG>GAT	p.E2005D		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2006										ovary(1)|skin(1)	2		Ovarian(137;0.0654)																---	---	---	---
PKD1L2	114780	broad.mit.edu	37	16	81242146	81242146	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81242146A>G	uc002fgh.1	-	4	710	c.710T>C	c.(709-711)CTG>CCG	p.L237P	PKD1L2_uc002fgj.2_Missense_Mutation_p.L237P	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	237	SUEL-type lectin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
CDT1	81620	broad.mit.edu	37	16	88871856	88871856	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88871856A>C	uc002flu.2	+	4	551	c.497A>C	c.(496-498)AAG>ACG	p.K166T		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	166	Interaction with GMNN.				DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)														---	---	---	---
ANKRD11	29123	broad.mit.edu	37	16	89345552	89345552	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89345552G>A	uc002fmx.1	-	9	7859	c.7398C>T	c.(7396-7398)TAC>TAT	p.Y2466Y	ANKRD11_uc002fmy.1_Silent_p.Y2466Y|ANKRD11_uc002fnc.1_Silent_p.Y2466Y|ANKRD11_uc002fna.1_Silent_p.Y131Y|ANKRD11_uc002fnb.1_Silent_p.Y2423Y	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2466						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)														---	---	---	---
SPG7	6687	broad.mit.edu	37	16	89592862	89592862	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89592862A>G	uc002fnj.2	+	5	765	c.744A>G	c.(742-744)ACA>ACG	p.T248T	SPG7_uc002fni.2_Silent_p.T248T	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	248	Mitochondrial intermembrane (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)														---	---	---	---
MYO1C	4641	broad.mit.edu	37	17	1371157	1371157	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1371157G>A	uc002fsp.2	-	29	3164	c.2944C>T	c.(2944-2946)CAG>TAG	p.Q982*	MYO1C_uc002fsn.2_Nonsense_Mutation_p.Q963*|MYO1C_uc002fso.2_Nonsense_Mutation_p.Q947*|MYO1C_uc010vqj.1_Nonsense_Mutation_p.Q947*	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	982					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
CAMKK1	84254	broad.mit.edu	37	17	3786411	3786411	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3786411C>T	uc002fwt.2	-	6	667	c.573G>A	c.(571-573)CTG>CTA	p.L191L	CAMKK1_uc002fwu.2_Silent_p.L191L|CAMKK1_uc002fwv.2_Silent_p.L191L	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	191	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)														---	---	---	---
ZZEF1	23140	broad.mit.edu	37	17	3936194	3936194	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3936194G>T	uc002fxe.2	-	41	6751	c.6687C>A	c.(6685-6687)TGC>TGA	p.C2229*	ZZEF1_uc002fxh.2_Nonsense_Mutation_p.C543*|ZZEF1_uc002fxi.2_Nonsense_Mutation_p.C464*	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2229							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
ZZEF1	23140	broad.mit.edu	37	17	3974039	3974039	+	Silent	SNP	G	A	A	rs115914263	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3974039G>A	uc002fxe.2	-	26	4078	c.4014C>T	c.(4012-4014)AAC>AAT	p.N1338N	ZZEF1_uc002fxj.1_Translation_Start_Site	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1338							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
ENO3	2027	broad.mit.edu	37	17	4856098	4856098	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4856098C>T	uc002gab.3	+	3	188	c.94C>T	c.(94-96)CGA>TGA	p.R32*	ENO3_uc010vsr.1_5'UTR|ENO3_uc002gac.3_Nonsense_Mutation_p.R32*|ENO3_uc010vss.1_Nonsense_Mutation_p.R32*|ENO3_uc010vst.1_5'Flank	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	32					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1																		---	---	---	---
SLC13A5	284111	broad.mit.edu	37	17	6606329	6606329	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6606329C>G	uc002gdj.2	-	5	764	c.676G>C	c.(676-678)GGG>CGG	p.G226R	SLC13A5_uc010vtf.1_Missense_Mutation_p.G226R|SLC13A5_uc010clq.2_Missense_Mutation_p.G183R|SLC13A5_uc002gdk.2_Missense_Mutation_p.G209R|SLC13A5_uc002gdl.1_Missense_Mutation_p.G208R	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	226	Helical; (Potential).					integral to membrane	citrate transmembrane transporter activity				0																		---	---	---	---
KDM6B	23135	broad.mit.edu	37	17	7752943	7752943	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7752943G>A	uc002giw.1	+	11	3713	c.3337G>A	c.(3337-3339)GGT>AGT	p.G1113S	KDM6B_uc002gix.2_Missense_Mutation_p.G415S	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1113					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
USP43	124739	broad.mit.edu	37	17	9631908	9631908	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9631908C>A	uc010cod.2	+	15	2973	c.2973C>A	c.(2971-2973)CCC>CCA	p.P991P	USP43_uc002gma.3_Silent_p.P680P|USP43_uc010vva.1_Silent_p.P986P|USP43_uc010coe.2_Silent_p.P788P|USP43_uc002gmc.3_Silent_p.P503P	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	991					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5																		---	---	---	---
MYH8	4626	broad.mit.edu	37	17	10315825	10315825	+	Silent	SNP	C	T	T	rs113680036	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10315825C>T	uc002gmm.2	-	14	1373	c.1278G>A	c.(1276-1278)GCG>GCA	p.A426A	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	426	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11														Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				---	---	---	---
DNAH9	1770	broad.mit.edu	37	17	11757384	11757384	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:11757384C>T	uc002gne.2	+	50	9640	c.9572C>T	c.(9571-9573)GCG>GTG	p.A3191V	DNAH9_uc010coo.2_Missense_Mutation_p.A2485V	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3191	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)														---	---	---	---
FLCN	201163	broad.mit.edu	37	17	17117130	17117130	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17117130G>A	uc002gra.3	-	14	2083	c.1579C>T	c.(1579-1581)CGA>TGA	p.R527*	PLD6_uc010cpn.2_Intron	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	527					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3														Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				---	---	---	---
SREBF1	6720	broad.mit.edu	37	17	17720700	17720700	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17720700C>T	uc002gru.1	-	8	1670	c.1476G>A	c.(1474-1476)ACG>ACA	p.T492T	SREBF1_uc002grp.1_Silent_p.T111T|SREBF1_uc002grq.1_Silent_p.T11T|SREBF1_uc002grr.1_Silent_p.T238T|SREBF1_uc002grs.1_Silent_p.T468T|SREBF1_uc002grt.1_Silent_p.T522T	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	492	Helical; (Potential).|Interaction with LMNA (By similarity).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1																		---	---	---	---
TOM1L2	146691	broad.mit.edu	37	17	17766052	17766052	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17766052G>A	uc002grz.3	-	11	1352	c.1195C>T	c.(1195-1197)CGC>TGC	p.R399C	TOM1L2_uc002gry.3_Missense_Mutation_p.R349C|TOM1L2_uc010vwy.1_Missense_Mutation_p.R346C|TOM1L2_uc010cpr.2_Missense_Mutation_p.R354C|TOM1L2_uc010vwz.1_Missense_Mutation_p.R251C|TOM1L2_uc010vxa.1_Missense_Mutation_p.R301C|TOM1L2_uc002grv.3_Missense_Mutation_p.R132C	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	399					intracellular protein transport	intracellular					0	all_neural(463;0.228)																	---	---	---	---
MYO15A	51168	broad.mit.edu	37	17	18023410	18023410	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18023410C>T	uc010vxh.1	+	2	1634	c.1296C>T	c.(1294-1296)ATC>ATT	p.I432I		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	432	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)																	---	---	---	---
MYO15A	51168	broad.mit.edu	37	17	18039027	18039027	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18039027G>A	uc010vxh.1	+	12	4823	c.4485G>A	c.(4483-4485)ACG>ACA	p.T1495T		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1495	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)																	---	---	---	---
LLGL1	3996	broad.mit.edu	37	17	18140176	18140176	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18140176G>A	uc002gsp.2	+	13	1595	c.1534G>A	c.(1534-1536)GAT>AAT	p.D512N		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	512					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)																	---	---	---	---
PRPSAP2	5636	broad.mit.edu	37	17	18781016	18781016	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18781016T>C	uc002gup.1	+	6	456	c.245T>C	c.(244-246)GTG>GCG	p.V82A	PRPSAP2_uc002guo.1_5'UTR|PRPSAP2_uc010vyi.1_Missense_Mutation_p.V30A|PRPSAP2_uc010vyj.1_5'UTR|PRPSAP2_uc010vyk.1_Missense_Mutation_p.V70A	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	82					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1																		---	---	---	---
MAP2K3	5606	broad.mit.edu	37	17	21215543	21215543	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:21215543G>A	uc002gys.2	+	10	1129	c.864G>A	c.(862-864)CAG>CAA	p.Q288Q	MAP2K3_uc002gyt.2_Silent_p.Q259Q|MAP2K3_uc002gyu.2_Silent_p.Q259Q	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	288	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)														---	---	---	---
NOS2	4843	broad.mit.edu	37	17	26116642	26116642	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26116642C>T	uc002gzu.2	-	3	447	c.183G>A	c.(181-183)GTG>GTA	p.V61V	NOS2_uc010crh.1_Silent_p.V61V|NOS2_uc010wab.1_Silent_p.V61V	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	61					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)													---	---	---	---
CRYBA1	1411	broad.mit.edu	37	17	27580761	27580761	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27580761T>C	uc002hdw.2	+	5	468	c.461T>C	c.(460-462)TTC>TCC	p.F154S		NM_005208	NP_005199	P05813	CRBA1_HUMAN	crystallin, beta A3	154	Beta/gamma crystallin 'Greek key' 3.				visual perception	soluble fraction	structural constituent of eye lens				0			BRCA - Breast invasive adenocarcinoma(11;3.3e-05)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)															---	---	---	---
ANKRD13B	124930	broad.mit.edu	37	17	27936411	27936411	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27936411C>T	uc002hei.2	+	7	907	c.794C>T	c.(793-795)ACG>ATG	p.T265M	ANKRD13B_uc002heh.2_Missense_Mutation_p.T133M|ANKRD13B_uc002hej.2_RNA	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	265											0																		---	---	---	---
ATAD5	79915	broad.mit.edu	37	17	29161234	29161234	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29161234A>G	uc002hfs.1	+	2	481	c.135A>G	c.(133-135)CCA>CCG	p.P45P	ATAD5_uc002hft.1_5'UTR	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	45					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)																---	---	---	---
ADAP2	55803	broad.mit.edu	37	17	29281495	29281495	+	Splice_Site	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29281495G>A	uc002hfx.2	+	9	1084	c.805_splice	c.e9-1	p.Q269_splice	ADAP2_uc010csk.2_Splice_Site_p.Q275_splice|ADAP2_uc002hfy.2_Intron|ADAP2_uc010csl.2_Splice_Site	NM_018404	NP_060874			centaurin-alpha 2 protein						heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		ovary(1)	1																		---	---	---	---
RHOT1	55288	broad.mit.edu	37	17	30536468	30536468	+	Intron	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30536468A>C	uc002hgz.2	+						RHOT1_uc002hgw.2_Intron|RHOT1_uc002hgy.2_Intron|RHOT1_uc002hha.2_Intron|RHOT1_uc010csv.2_Intron|RHOT1_uc002hgx.2_Intron|RHOT1_uc010wby.1_Intron|RHOT1_uc002hhb.2_Intron|RHOT1_uc002hgv.2_3'UTR	NM_018307	NP_060777			ras homolog gene family, member T1 isoform 3						apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)																---	---	---	---
PSMD11	5717	broad.mit.edu	37	17	30796051	30796051	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30796051C>T	uc010cta.1	+	6	523	c.483C>T	c.(481-483)GAC>GAT	p.D161D	PSMD11_uc010wbz.1_Silent_p.D161D|PSMD11_uc002hhm.2_Silent_p.D161D	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	161					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)															---	---	---	---
CCL7	6354	broad.mit.edu	37	17	32597332	32597332	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:32597332T>G	uc002hhz.2	+	1	93	c.23T>G	c.(22-24)CTG>CGG	p.L8R	CCL7_uc010ctf.2_RNA	NM_006273	NP_006264	P80098	CCL7_HUMAN	chemokine (C-C motif) ligand 7 precursor	8					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			ovary(1)	1	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)														---	---	---	---
SLFN12	55106	broad.mit.edu	37	17	33749721	33749721	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33749721T>C	uc002hji.3	-	2	704	c.327A>G	c.(325-327)TCA>TCG	p.S109S	SLFN12_uc002hjj.3_Silent_p.S109S|SLFN12_uc010cts.2_Silent_p.S109S	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	109							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)														---	---	---	---
MMP28	79148	broad.mit.edu	37	17	34106027	34106027	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34106027T>C	uc002hjy.1	-	3	503	c.244A>G	c.(244-246)ACC>GCC	p.T82A	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA|MMP28_uc002hka.2_Missense_Mutation_p.T82A	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	82					proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)														---	---	---	---
C17orf66	256957	broad.mit.edu	37	17	34192249	34192249	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34192249T>A	uc002hke.1	-	3	439	c.290A>T	c.(289-291)AAG>ATG	p.K97M	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Missense_Mutation_p.K97M|C17orf66_uc010wcm.1_Missense_Mutation_p.K63M	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	97							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)														---	---	---	---
MYO19	80179	broad.mit.edu	37	17	34856703	34856703	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34856703G>A	uc010wcy.1	-	24	3336	c.2344C>T	c.(2344-2346)CGG>TGG	p.R782W	MYO19_uc002hmw.2_Missense_Mutation_p.R582W|MYO19_uc010cuu.2_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	782						mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)														---	---	---	---
GGNBP2	79893	broad.mit.edu	37	17	34913105	34913105	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34913105G>T	uc002hnb.2	+	4	606	c.357G>T	c.(355-357)AAG>AAT	p.K119N	GGNBP2_uc002hna.2_Missense_Mutation_p.K119N	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	119					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)														---	---	---	---
GRB7	2886	broad.mit.edu	37	17	37899217	37899217	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37899217C>T	uc002hsr.2	+	4	623	c.373C>T	c.(373-375)CGC>TGC	p.R125C	GRB7_uc002hss.2_Missense_Mutation_p.R125C|GRB7_uc010cwc.2_Missense_Mutation_p.R125C|GRB7_uc002hst.2_Missense_Mutation_p.R125C	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	125	Ras-associating.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)															---	---	---	---
RARA	5914	broad.mit.edu	37	17	38510653	38510653	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38510653G>A	uc002huk.1	+	7	1362	c.907G>A	c.(907-909)GGC>AGC	p.G303S	RARA_uc002hul.3_Missense_Mutation_p.G303S|RARA_uc010wfe.1_Missense_Mutation_p.G206S|RARA_uc002hun.1_Missense_Mutation_p.G298S	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	303	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)			T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								---	---	---	---
KRT222	125113	broad.mit.edu	37	17	38818172	38818172	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38818172G>A	uc002hvc.2	-	2	286	c.221C>T	c.(220-222)GCT>GTT	p.A74V	KRT222_uc010wfk.1_RNA|KRT222_uc002hvb.2_Missense_Mutation_p.A34V|KRT222_uc010cxc.2_Missense_Mutation_p.A34V	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	74	Potential.					intermediate filament	structural molecule activity			central_nervous_system(1)|skin(1)	2																		---	---	---	---
HDAC5	10014	broad.mit.edu	37	17	42162480	42162480	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42162480G>A	uc002ifd.1	-	15	2305	c.2094C>T	c.(2092-2094)TGC>TGT	p.C698C	HDAC5_uc002ife.1_Silent_p.C698C|HDAC5_uc002iff.1_Silent_p.C699C|HDAC5_uc010czp.1_Intron|HDAC5_uc002ifg.1_Silent_p.C8C|HDAC5_uc002ifh.2_Silent_p.C698C	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	698	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)														---	---	---	---
GRN	2896	broad.mit.edu	37	17	42426635	42426635	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42426635G>A	uc002igp.1	+	2	322	c.103G>A	c.(103-105)GGA>AGA	p.G35R	GRN_uc002igq.1_Missense_Mutation_p.G35R|GRN_uc002igr.1_5'Flank	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	35					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)														---	---	---	---
ADAM11	4185	broad.mit.edu	37	17	42854609	42854609	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42854609C>A	uc002ihh.2	+	21	1757	c.1757C>A	c.(1756-1758)TCT>TAT	p.S586Y	ADAM11_uc010wjd.1_Missense_Mutation_p.S386Y|ADAM11_uc002ihi.2_5'Flank	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	586	Cys-rich.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)																---	---	---	---
MAP3K14	9020	broad.mit.edu	37	17	43350933	43350933	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43350933G>T	uc002iiw.1	-	10	1703	c.1594C>A	c.(1594-1596)CTC>ATC	p.L532I	MAP3K14_uc002iiu.1_Missense_Mutation_p.L62I|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Missense_Mutation_p.L116I	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	532	Interaction with ZFP91.|Protein kinase.				cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8																		---	---	---	---
KIAA1267	284058	broad.mit.edu	37	17	44249126	44249126	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44249126C>T	uc002ikb.2	-	1	469	c.384G>A	c.(382-384)CAG>CAA	p.Q128Q	KIAA1267_uc002ikc.2_Silent_p.Q128Q|KIAA1267_uc002ikd.2_Silent_p.Q128Q|KIAA1267_uc010dav.2_Silent_p.Q128Q	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	128						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)																---	---	---	---
HEATR6	63897	broad.mit.edu	37	17	58132907	58132907	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58132907G>A	uc002iyk.1	-	14	2275	c.2258C>T	c.(2257-2259)GCA>GTA	p.A753V	HEATR6_uc010ddk.1_Missense_Mutation_p.A292V|HEATR6_uc010wos.1_Intron	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	753				A -> T (in Ref. 5; AAL83912).			binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)															---	---	---	---
AMZ2	51321	broad.mit.edu	37	17	66246991	66246991	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66246991T>G	uc002jgs.1	+	4	457	c.340T>G	c.(340-342)TAC>GAC	p.Y114D	AMZ2_uc002jgr.1_Missense_Mutation_p.Y114D|AMZ2_uc002jgt.1_Missense_Mutation_p.Y114D|AMZ2_uc002jgu.1_Missense_Mutation_p.Y114D|AMZ2_uc002jgv.1_Missense_Mutation_p.Y114D|AMZ2_uc002jgw.1_Intron|AMZ2_uc002jgy.1_Missense_Mutation_p.Y114D	NM_001033572	NP_001028744	Q86W34	AMZ2_HUMAN	archaemetzincins-2 isoform 1	114							metallopeptidase activity|zinc ion binding				0	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
SOX9	6662	broad.mit.edu	37	17	70120097	70120097	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:70120097C>A	uc002jiw.2	+	3	1471	c.1099C>A	c.(1099-1101)CCA>ACA	p.P367T		NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	367	Gln/Pro-rich.				cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)															---	---	---	---
SLC39A11	201266	broad.mit.edu	37	17	70645098	70645098	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:70645098T>C	uc002jjb.2	-	9	909	c.794A>G	c.(793-795)TAT>TGT	p.Y265C	SLC39A11_uc002jja.2_Missense_Mutation_p.Y258C	NM_001159770	NP_001153242	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11 isoform 1	265	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)	1																		---	---	---	---
C17orf80	55028	broad.mit.edu	37	17	71238436	71238436	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:71238436G>A	uc002jjm.3	+	4	1761	c.1567G>A	c.(1567-1569)GGA>AGA	p.G523R	C17orf80_uc010wqu.1_Intron|C17orf80_uc010dfj.2_Intron|C17orf80_uc002jjk.1_Missense_Mutation_p.G523R|C17orf80_uc002jjl.3_Intron	NM_017941	NP_060411	Q9BSJ5	CQ080_HUMAN	lung cancer-related protein 8 isoform a	523	Extracellular (Potential).					integral to membrane				skin(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)															---	---	---	---
GRIN2C	2905	broad.mit.edu	37	17	72846719	72846719	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72846719C>T	uc002jlt.1	-	5	1457	c.1301G>A	c.(1300-1302)CGC>CAC	p.R434H	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.R434H|GRIN2C_uc002jlv.1_3'UTR	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	434	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)													---	---	---	---
C17orf28	283987	broad.mit.edu	37	17	72956269	72956269	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72956269T>C	uc002jmj.3	-	7	952	c.803A>G	c.(802-804)TAC>TGC	p.Y268C	C17orf28_uc010wrs.1_Missense_Mutation_p.Y67C|C17orf28_uc002jmk.2_Missense_Mutation_p.Y267C	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	268						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)																	---	---	---	---
NUP85	79902	broad.mit.edu	37	17	73231232	73231232	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73231232G>A	uc002jng.1	+	18	2065	c.1805G>A	c.(1804-1806)CGG>CAG	p.R602Q	NUP85_uc010dgd.1_Missense_Mutation_p.R557Q|NUP85_uc010wrv.1_Missense_Mutation_p.R556Q|NUP85_uc002jnh.1_Missense_Mutation_p.R205Q	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	602					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)															---	---	---	---
MIF4GD	57409	broad.mit.edu	37	17	73263620	73263620	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73263620T>A	uc002jnr.2	-	5	569	c.440A>T	c.(439-441)GAG>GTG	p.E147V	MIF4GD_uc002jno.2_Missense_Mutation_p.E188V|MIF4GD_uc002jnp.2_Missense_Mutation_p.E181V|MIF4GD_uc002jnq.2_Missense_Mutation_p.E188V			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	147	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)															---	---	---	---
LLGL2	3993	broad.mit.edu	37	17	73560538	73560538	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73560538C>A	uc002joh.2	+	10	1140	c.986C>A	c.(985-987)ACC>AAC	p.T329N	LLGL2_uc002jog.1_Missense_Mutation_p.T329N|LLGL2_uc010dgf.1_Missense_Mutation_p.T329N|LLGL2_uc002joi.2_Missense_Mutation_p.T329N|LLGL2_uc010dgg.1_Missense_Mutation_p.T329N|LLGL2_uc002joj.2_Missense_Mutation_p.T318N|LLGL2_uc010wsd.1_Missense_Mutation_p.P10T|uc002jok.2_5'Flank	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	329					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)															---	---	---	---
FBF1	85302	broad.mit.edu	37	17	73917331	73917331	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73917331G>A	uc002jqc.2	-	16	1897	c.1623C>T	c.(1621-1623)CCC>CCT	p.P541P	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Silent_p.P532P|FBF1_uc002jqd.1_Silent_p.P542P|FBF1_uc002jqb.2_5'Flank|FBF1_uc010dgr.1_5'UTR	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	541											0																		---	---	---	---
TBC1D16	125058	broad.mit.edu	37	17	77923563	77923563	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:77923563C>T	uc002jxj.2	-	7	1475	c.1359G>A	c.(1357-1359)GCG>GCA	p.A453A	TBC1D16_uc002jxh.2_Silent_p.A91A|TBC1D16_uc002jxi.2_Silent_p.A78A|TBC1D16_uc002jxk.1_Silent_p.A91A	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	453	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)															---	---	---	---
GAA	2548	broad.mit.edu	37	17	78091485	78091485	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78091485G>A	uc002jxo.2	+	18	2600	c.2418G>A	c.(2416-2418)ACG>ACA	p.T806T	GAA_uc002jxp.2_Silent_p.T806T|GAA_uc002jxq.2_Silent_p.T806T	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	806					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)													---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78318484	78318484	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78318484C>T	uc002jyh.1	+	4	791	c.568C>T	c.(568-570)CGT>TGT	p.R190C		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
RPTOR	57521	broad.mit.edu	37	17	78727978	78727978	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78727978C>A	uc002jyt.1	+	6	1628	c.823C>A	c.(823-825)CTG>ATG	p.L275M	RPTOR_uc002jys.2_Missense_Mutation_p.L275M|RPTOR_uc010wuf.1_Missense_Mutation_p.L90M|RPTOR_uc010wug.1_Missense_Mutation_p.L275M	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	275					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6																		---	---	---	---
RPTOR	57521	broad.mit.edu	37	17	78897301	78897301	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78897301C>T	uc002jyt.1	+	23	3441	c.2636C>T	c.(2635-2637)CCG>CTG	p.P879L	RPTOR_uc010wug.1_Missense_Mutation_p.P721L	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	879					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6																		---	---	---	---
BAIAP2	10458	broad.mit.edu	37	17	79077412	79077412	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79077412C>T	uc002jzg.2	+	8	861	c.753C>T	c.(751-753)GGC>GGT	p.G251G	BAIAP2_uc002jyz.3_Silent_p.G251G|BAIAP2_uc002jza.2_Silent_p.G251G|BAIAP2_uc002jzc.2_Silent_p.G251G|BAIAP2_uc002jzb.2_Silent_p.G8G|BAIAP2_uc002jzd.2_Silent_p.G251G|BAIAP2_uc002jzf.2_Silent_p.G251G|BAIAP2_uc002jze.2_Silent_p.G284G|BAIAP2_uc010wuh.1_Silent_p.G173G|BAIAP2_uc002jzh.2_Silent_p.G252G|BAIAP2_uc010wui.1_Silent_p.G114G	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	251					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)															---	---	---	---
BAHCC1	57597	broad.mit.edu	37	17	79381160	79381160	+	Intron	SNP	C	T	T	rs116128116	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79381160C>T	uc002kaf.2	+							NM_001080519	NP_001073988			BAH domain and coiled-coil containing 1								DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)															---	---	---	---
C17orf70	80233	broad.mit.edu	37	17	79508363	79508363	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79508363T>C	uc002kaq.2	-	8	2541	c.2486A>G	c.(2485-2487)TAC>TGC	p.Y829C	C17orf70_uc002kao.1_Missense_Mutation_p.Y478C|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Missense_Mutation_p.Y678C	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	829					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)															---	---	---	---
CCDC57	284001	broad.mit.edu	37	17	80141780	80141780	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80141780A>T	uc002kdz.1	-	9	1436	c.1081T>A	c.(1081-1083)TCT>ACT	p.S361T	CCDC57_uc002kdx.1_Missense_Mutation_p.S361T|CCDC57_uc010dik.1_5'UTR	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	361	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)															---	---	---	---
SMCHD1	23347	broad.mit.edu	37	18	2707836	2707836	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2707836A>G	uc002klm.3	+	17	2367	c.2178A>G	c.(2176-2178)AAA>AAG	p.K726K	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	726					chromosome organization		ATP binding				0																		---	---	---	---
SMCHD1	23347	broad.mit.edu	37	18	2752539	2752539	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2752539C>T	uc002klm.3	+	34	4524	c.4335C>T	c.(4333-4335)TGC>TGT	p.C1445C	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1445					chromosome organization		ATP binding				0																		---	---	---	---
TMEM200C	645369	broad.mit.edu	37	18	5890416	5890416	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:5890416C>T	uc002kmx.1	-	1	1688	c.1647G>A	c.(1645-1647)TCG>TCA	p.S549S		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	549						integral to membrane					0																		---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	7050823	7050823	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7050823G>A	uc002knm.2	-	4	552	c.458C>T	c.(457-459)GCA>GTA	p.A153V	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	153	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
RALBP1	10928	broad.mit.edu	37	18	9535730	9535730	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:9535730G>A	uc002kob.2	+	10	1986	c.1763G>A	c.(1762-1764)CGC>CAC	p.R588H	RALBP1_uc002koc.2_Missense_Mutation_p.R588H	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	588					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1																		---	---	---	---
FAM38B	63895	broad.mit.edu	37	18	10671626	10671626	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:10671626C>T	uc002kor.3	-	14	2168	c.2028G>A	c.(2026-2028)GAG>GAA	p.E676E	FAM38B_uc002koq.2_Silent_p.E511E	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2719						integral to membrane	ion channel activity			ovary(1)	1																		---	---	---	---
MPPE1	65258	broad.mit.edu	37	18	11886493	11886493	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:11886493C>T	uc002kqf.2	-						MPPE1_uc002kqn.2_Intron|MPPE1_uc002kqg.2_Intron|MPPE1_uc002kqh.2_Intron|MPPE1_uc002kqi.2_Intron|MPPE1_uc002kqj.2_Intron|MPPE1_uc002kqk.2_Intron|MPPE1_uc002kql.2_Intron|MPPE1_uc002kqm.2_Intron|MPPE1_uc010dla.1_Missense_Mutation_p.C292Y	NM_023075	NP_075563			metallophosphoesterase 1 precursor						ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0																		---	---	---	---
PTPN2	5771	broad.mit.edu	37	18	12802072	12802072	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12802072A>G	uc002krp.2	-	8	1131	c.937T>C	c.(937-939)TAC>CAC	p.Y313H	PTPN2_uc002krl.2_Missense_Mutation_p.Y313H|PTPN2_uc002krn.2_Missense_Mutation_p.Y336H|PTPN2_uc002kro.2_Missense_Mutation_p.Y313H|PTPN2_uc002krm.2_Missense_Mutation_p.Y313H	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	313					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)																---	---	---	---
ROCK1	6093	broad.mit.edu	37	18	18622646	18622646	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:18622646C>T	uc002kte.2	-	7	1641	c.700G>A	c.(700-702)GCG>ACG	p.A234T		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	234	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)																	---	---	---	---
SNRPD1	6632	broad.mit.edu	37	18	19209067	19209067	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19209067C>T	uc002ktj.1	+	4	459	c.328C>T	c.(328-330)CGT>TGT	p.R110C		NM_006938	NP_008869	P62314	SMD1_HUMAN	small nuclear ribonucleoprotein D1 polypeptide	110	Arg/Lys-rich (basic).				ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding|RNA binding				0																		---	---	---	---
CTAGE1	64693	broad.mit.edu	37	18	19997258	19997258	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19997258G>A	uc002ktv.1	-	1	621	c.517C>T	c.(517-519)CGG>TGG	p.R173W		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	173	Potential.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)																	---	---	---	---
RBBP8	5932	broad.mit.edu	37	18	20573099	20573099	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:20573099C>A	uc002ktw.2	+	11	1640	c.1309C>A	c.(1309-1311)CTG>ATG	p.L437M	RBBP8_uc002kty.2_Missense_Mutation_p.L437M|RBBP8_uc002ktz.2_Missense_Mutation_p.L437M|RBBP8_uc002kua.2_Missense_Mutation_p.L437M|RBBP8_uc002ktx.1_Missense_Mutation_p.L437M	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	437					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)										Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
NPC1	4864	broad.mit.edu	37	18	21114443	21114443	+	Silent	SNP	G	A	A	rs141659629	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21114443G>A	uc002kum.3	-	23	3832	c.3558C>T	c.(3556-3558)CGC>CGT	p.R1186R	NPC1_uc010dlu.1_5'Flank|NPC1_uc010xaz.1_Silent_p.R919R	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	1186			R -> H (in NPC1).		autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
ZNF521	25925	broad.mit.edu	37	18	22804544	22804544	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:22804544G>A	uc002kvk.2	-	4	3585	c.3338C>T	c.(3337-3339)ACG>ATG	p.T1113M	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.T1113M|ZNF521_uc002kvl.2_Missense_Mutation_p.T893M	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1113					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)							T	PAX5	ALL								---	---	---	---
CDH2	1000	broad.mit.edu	37	18	25568495	25568495	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:25568495A>G	uc002kwg.2	-	11	2193	c.1734T>C	c.(1732-1734)TCT>TCC	p.S578S	CDH2_uc010xbn.1_Silent_p.S547S	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	578	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4																		---	---	---	---
ELP2	55250	broad.mit.edu	37	18	33713227	33713227	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33713227T>C	uc002kzk.1	+	2	175	c.165T>C	c.(163-165)AAT>AAC	p.N55N	ELP2_uc010xcg.1_Silent_p.N55N|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Silent_p.N55N|ELP2_uc010xch.1_Silent_p.N55N|ELP2_uc002kzn.1_Silent_p.N55N|ELP2_uc002kzo.1_Silent_p.N55N	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	55					regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
FHOD3	80206	broad.mit.edu	37	18	34298520	34298520	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:34298520C>T	uc002kzt.1	+	15	2780	c.2683C>T	c.(2683-2685)CGT>TGT	p.R895C	FHOD3_uc002kzs.1_Missense_Mutation_p.R912C|FHOD3_uc010dmz.1_Missense_Mutation_p.R627C|FHOD3_uc010dna.1_Missense_Mutation_p.R215C	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	895	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)																---	---	---	---
SETBP1	26040	broad.mit.edu	37	18	42533097	42533097	+	Silent	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:42533097T>G	uc010dni.2	+	4	4088	c.3792T>G	c.(3790-3792)TCT>TCG	p.S1264S		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1264						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)										Schinzel-Giedion_syndrome				---	---	---	---
ACAA2	10449	broad.mit.edu	37	18	47340396	47340396	+	5'Flank	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47340396G>T	uc002ldw.3	-						ACAA2_uc002ldx.3_5'Flank|SCARNA17_uc002ldy.1_RNA	NM_006111	NP_006102			acetyl-coenzyme A acyltransferase 2						anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1																		---	---	---	---
MYO5B	4645	broad.mit.edu	37	18	47479669	47479669	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47479669C>A	uc002leb.2	-	14	2001	c.1713G>T	c.(1711-1713)ACG>ACT	p.T571T	MYO5B_uc002lec.1_Silent_p.T570T	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	571	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)														---	---	---	---
FECH	2235	broad.mit.edu	37	18	55240556	55240556	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55240556G>T	uc002lgq.3	-	3	353	c.236C>A	c.(235-237)CCT>CAT	p.P79H	FECH_uc002lgp.3_Missense_Mutation_p.P85H|FECH_uc002lgr.3_Translation_Start_Site	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	79					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)	1		Colorectal(73;0.227)																---	---	---	---
ZNF532	55205	broad.mit.edu	37	18	56586342	56586342	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56586342G>A	uc002lho.2	+	4	1370	c.823G>A	c.(823-825)GCG>ACG	p.A275T	ZNF532_uc002lhp.2_Missense_Mutation_p.A273T|ZNF532_uc010xeg.1_Missense_Mutation_p.A273T|ZNF532_uc002lhr.2_Missense_Mutation_p.A273T|ZNF532_uc002lhs.2_Missense_Mutation_p.A273T	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	275					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2																		---	---	---	---
CDH20	28316	broad.mit.edu	37	18	59195263	59195263	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:59195263G>T	uc010dps.1	+	6	1093	c.1081G>T	c.(1081-1083)GAG>TAG	p.E361*	CDH20_uc002lif.2_Nonsense_Mutation_p.E355*	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	361	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)																---	---	---	---
SERPINB5	5268	broad.mit.edu	37	18	61170598	61170598	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:61170598G>A	uc002liz.3	+	7	913	c.771G>A	c.(769-771)CAG>CAA	p.Q257Q		NM_002639	NP_002630	P36952	SPB5_HUMAN	serine (or cysteine) proteinase inhibitor, clade	257					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1																		---	---	---	---
CDH19	28513	broad.mit.edu	37	18	64202234	64202234	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:64202234G>A	uc002lkc.1	-	8	1463	c.1325C>T	c.(1324-1326)GCC>GTC	p.A442V	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.A442V|CDH19_uc002lkd.2_Missense_Mutation_p.A442V	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	442	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)																---	---	---	---
TSHZ1	10194	broad.mit.edu	37	18	72999092	72999092	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:72999092C>A	uc002lly.2	+	2	2158	c.1595C>A	c.(1594-1596)CCC>CAC	p.P532H		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	577						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)														---	---	---	---
SALL3	27164	broad.mit.edu	37	18	76752144	76752144	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:76752144C>T	uc002lmt.2	+	2	153	c.153C>T	c.(151-153)AGC>AGT	p.S51S	SALL3_uc010dra.2_5'Flank	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	51					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)														---	---	---	---
NFATC1	4772	broad.mit.edu	37	18	77170569	77170569	+	Silent	SNP	G	T	T	rs2230113	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77170569G>T	uc010xfg.1	+	2	747	c.294G>T	c.(292-294)GCG>GCT	p.A98A	NFATC1_uc002lnc.1_Silent_p.A98A|NFATC1_uc010xff.1_Silent_p.A98A|NFATC1_uc002lnd.2_Silent_p.A98A|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Silent_p.A98A|NFATC1_uc010xfi.1_Silent_p.A85A|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Silent_p.A85A|NFATC1_uc002lng.2_Silent_p.A85A|NFATC1_uc010xfk.1_Silent_p.A85A	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	98					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)														---	---	---	---
NFATC1	4772	broad.mit.edu	37	18	77171052	77171052	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77171052C>T	uc010xfg.1	+	2	1230	c.777C>T	c.(775-777)CCC>CCT	p.P259P	NFATC1_uc002lnc.1_Silent_p.P259P|NFATC1_uc010xff.1_Silent_p.P259P|NFATC1_uc002lnd.2_Silent_p.P259P|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Silent_p.P259P|NFATC1_uc010xfi.1_Silent_p.P246P|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Silent_p.P246P|NFATC1_uc002lng.2_Silent_p.P246P|NFATC1_uc010xfk.1_Silent_p.P246P	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	259	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)														---	---	---	---
FSTL3	10272	broad.mit.edu	37	19	681492	681492	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:681492G>A	uc002lpk.1	+	4	700	c.665G>A	c.(664-666)TGC>TAC	p.C222Y	FSTL3_uc010drt.1_RNA	NM_005860	NP_005851	O95633	FSTL3_HUMAN	follistatin-like 3 glycoprotein precursor	222	Kazal-like 2.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)				T	CCND1	B-CLL								---	---	---	---
C19orf26	255057	broad.mit.edu	37	19	1235774	1235774	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1235774G>A	uc002lrm.2	-							NM_152769	NP_689982			downstream of Stk11							integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)											HNSCC(14;0.022)			---	---	---	---
ZNF554	115196	broad.mit.edu	37	19	2832394	2832394	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2832394C>T	uc002lwm.2	+	4	545	c.347C>T	c.(346-348)ACG>ATG	p.T116M	ZNF554_uc002lwl.2_Missense_Mutation_p.T65M	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	116	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
S1PR4	8698	broad.mit.edu	37	19	3179131	3179131	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3179131C>T	uc002lxg.2	+	1	366	c.341C>T	c.(340-342)GCG>GTG	p.A114V		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	114	Extracellular (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2																		---	---	---	---
NFIC	4782	broad.mit.edu	37	19	3382065	3382065	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3382065G>A	uc010xhi.1	+	2	448	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	NFIC_uc002lxo.2_Missense_Mutation_p.R120Q|NFIC_uc010xhh.1_Missense_Mutation_p.R120Q|NFIC_uc002lxp.2_Missense_Mutation_p.R129Q|NFIC_uc010xhj.1_Missense_Mutation_p.R129Q|NFIC_uc002lxq.1_Missense_Mutation_p.R81Q	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	129	CTF/NF-I.				DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)														---	---	---	---
CHAF1A	10036	broad.mit.edu	37	19	4430624	4430624	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4430624G>A	uc002mal.2	+	11	2033	c.1933G>A	c.(1933-1935)GAA>AAA	p.E645K		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	645	Necessary for homodimerization and competence for chromatin assembly.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)									Chromatin_Structure					---	---	---	---
PLIN4	729359	broad.mit.edu	37	19	4510529	4510529	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4510529C>T	uc002mar.1	-	3	3401	c.3401G>A	c.(3400-3402)CGC>CAC	p.R1134H	PLIN4_uc010dub.1_Missense_Mutation_p.R158H	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	1134						lipid particle|plasma membrane					0																		---	---	---	---
TNFAIP8L1	126282	broad.mit.edu	37	19	4651883	4651883	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4651883T>C	uc002max.2	+	2	117	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_152362	NP_689575	Q8WVP5	TP8L1_HUMAN	tumor necrosis factor, alpha-induced protein	1											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
KDM4B	23030	broad.mit.edu	37	19	5110659	5110659	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5110659G>A	uc002mbq.3	+	10	1171	c.945G>A	c.(943-945)AAG>AAA	p.K315K	KDM4B_uc010xil.1_Silent_p.K315K|KDM4B_uc010xim.1_Silent_p.K315K|KDM4B_uc002mbr.3_Silent_p.K73K	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	315					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1																		---	---	---	---
PTPRS	5802	broad.mit.edu	37	19	5212258	5212258	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5212258G>A	uc002mbv.2	-	32	5007	c.4773C>T	c.(4771-4773)GCC>GCT	p.A1591A	PTPRS_uc002mbu.1_Silent_p.A1160A|PTPRS_uc010xin.1_Silent_p.A1133A|PTPRS_uc002mbw.2_Silent_p.A1553A|PTPRS_uc002mbx.2_Silent_p.A1148A|PTPRS_uc002mby.2_Silent_p.A1144A	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1591	Substrate binding (By similarity).|Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)														---	---	---	---
ZNRF4	148066	broad.mit.edu	37	19	5456550	5456550	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5456550G>A	uc002mca.3	+	1	1125	c.1048G>A	c.(1048-1050)GTG>ATG	p.V350M		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	350	RING-type; atypical.|Cytoplasmic (Potential).					integral to membrane	zinc ion binding	p.V350M(1)		large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)														---	---	---	---
ALKBH7	84266	broad.mit.edu	37	19	6374236	6374236	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6374236C>T	uc002meo.1	+	2	615	c.227C>T	c.(226-228)ACA>ATA	p.T76I		NM_032306	NP_115682	Q9BT30	ALKB7_HUMAN	spermatogenesis associated 11 precursor	76						extracellular region|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0																		---	---	---	---
C3	718	broad.mit.edu	37	19	6718271	6718271	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6718271G>A	uc002mfm.2	-	3	482	c.420C>T	c.(418-420)ACC>ACT	p.T140T		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	140					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)														---	---	---	---
EMR4P	326342	broad.mit.edu	37	19	6986350	6986350	+	5'UTR	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6986350C>T	uc010xjk.1	-	3					EMR4P_uc010dve.1_RNA	NR_024075				RecName: Full=Putative EGF-like module-containing mucin-like hormone receptor-like 4; AltName: Full=G-protein coupled receptor 127; AltName: Full=G-protein coupled receptor PGR16; Flags: Precursor;												0																		---	---	---	---
INSR	3643	broad.mit.edu	37	19	7120730	7120730	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7120730G>A	uc002mgd.1	-	20	3669	c.3560C>T	c.(3559-3561)ACG>ATG	p.T1187M	INSR_uc002mge.1_Missense_Mutation_p.T1175M	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1187	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
ELAVL1	1994	broad.mit.edu	37	19	8028545	8028545	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8028545C>T	uc002mjb.2	-	6	970	c.803G>A	c.(802-804)GGT>GAT	p.G268D		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	268	RRM 3.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0																		---	---	---	---
FBN3	84467	broad.mit.edu	37	19	8182094	8182094	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8182094C>T	uc002mjf.2	-	27	3566	c.3545G>A	c.(3544-3546)GGG>GAG	p.G1182E		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1182	EGF-like 16; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11																		---	---	---	---
ACTL9	284382	broad.mit.edu	37	19	8808202	8808202	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8808202C>T	uc002mkl.2	-	1	971	c.850G>A	c.(850-852)GAT>AAT	p.D284N		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	284						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9049116	9049116	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9049116T>C	uc002mkp.2	-	5	32719	c.32515A>G	c.(32515-32517)ACT>GCT	p.T10839A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10841	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
ANGPTL6	83854	broad.mit.edu	37	19	10204415	10204415	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10204415C>A	uc002mmx.1	-	4	1023	c.905G>T	c.(904-906)AGG>ATG	p.R302M	ANGPTL6_uc002mmy.1_Missense_Mutation_p.R302M	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	302	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)															---	---	---	---
PPAN-P2RY11	692312	broad.mit.edu	37	19	10218766	10218766	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10218766G>A	uc002mna.2	+	5	469	c.469G>A	c.(469-471)GCC>ACC	p.A157T	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.A157T|PPAN_uc002mmz.1_Missense_Mutation_p.A157T|PPAN_uc002mnb.1_Missense_Mutation_p.A104T|SNORD105B_uc010dwz.1_5'Flank	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	157	Brix.				RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)															---	---	---	---
S1PR2	9294	broad.mit.edu	37	19	10335348	10335348	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10335348G>A	uc002mnl.2	-	2	345	c.234C>T	c.(232-234)TCC>TCT	p.S78S		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	78	Helical; Name=2; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2																		---	---	---	---
KEAP1	9817	broad.mit.edu	37	19	10602646	10602646	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10602646T>C	uc002moq.1	-	3	1088	c.932A>G	c.(931-933)CAC>CGC	p.H311R	KEAP1_uc002mop.1_Missense_Mutation_p.H29R|KEAP1_uc002mor.1_Missense_Mutation_p.H311R	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)															---	---	---	---
KANK2	25959	broad.mit.edu	37	19	11304273	11304273	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11304273G>A	uc010dxv.2	-	6	1041	c.483C>T	c.(481-483)GGC>GGT	p.G161G	KANK2_uc002mqm.2_Silent_p.G161G|KANK2_uc002mqo.3_Silent_p.G161G|KANK2_uc002mqp.1_5'UTR|KANK2_uc002mqq.2_Silent_p.G161G	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	161											0																		---	---	---	---
CCDC151	115948	broad.mit.edu	37	19	11532334	11532334	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11532334C>T	uc002mrs.2	-						CCDC151_uc002mrr.2_Intron|CCDC151_uc010dxz.2_Intron|RGL3_uc002mrn.2_5'Flank|RGL3_uc002mrm.2_5'Flank|RGL3_uc002mro.2_5'Flank|RGL3_uc002mrp.2_5'Flank|RGL3_uc002mrq.2_5'Flank	NM_145045	NP_659482			coiled-coil domain containing 151											ovary(1)	1																		---	---	---	---
MAN2B1	4125	broad.mit.edu	37	19	12776529	12776529	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12776529A>G	uc002mub.2	-	2	326	c.250T>C	c.(250-252)TAC>CAC	p.Y84H	MAN2B1_uc010dyv.1_Missense_Mutation_p.Y84H|WDR83_uc002mue.3_5'Flank|WDR83_uc002muc.2_5'Flank	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	84					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
TNPO2	30000	broad.mit.edu	37	19	12812476	12812476	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12812476A>G	uc002muo.2	-	23	2707	c.2522T>C	c.(2521-2523)TTC>TCC	p.F841S	TNPO2_uc002mup.2_Missense_Mutation_p.F923S|TNPO2_uc002muq.2_Missense_Mutation_p.F831S|TNPO2_uc002mur.2_Missense_Mutation_p.F831S	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	841				F -> L (in Ref. 2; AAB71349).	intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1																		---	---	---	---
NOTCH3	4854	broad.mit.edu	37	19	15285059	15285059	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15285059A>G	uc002nan.2	-	25	4632	c.4556T>C	c.(4555-4557)CTG>CCG	p.L1519P		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1519	Extracellular (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)															---	---	---	---
AKAP8	10270	broad.mit.edu	37	19	15483890	15483890	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15483890C>T	uc002nav.2	-	5	694	c.633G>A	c.(631-633)GTG>GTA	p.V211V	AKAP8_uc010dzy.2_5'UTR|AKAP8_uc010dzz.1_RNA|AKAP8_uc010xog.1_Silent_p.V25V	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	211					signal transduction	nuclear matrix				ovary(1)|breast(1)	2																		---	---	---	---
CYP4F22	126410	broad.mit.edu	37	19	15636311	15636311	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15636311G>A	uc002nbh.3	+	3	331	c.164G>A	c.(163-165)CGG>CAG	p.R55Q		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	55						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2																		---	---	---	---
CYP4F22	126410	broad.mit.edu	37	19	15648384	15648384	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15648384C>T	uc002nbh.3	+	6	627	c.460C>T	c.(460-462)CGG>TGG	p.R154W		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	154						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2																		---	---	---	---
CYP4F3	4051	broad.mit.edu	37	19	15769071	15769071	+	Intron	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15769071T>C	uc002nbj.2	+						CYP4F3_uc010xok.1_Intron|CYP4F3_uc010xol.1_Intron|CYP4F3_uc010xom.1_Intron|CYP4F3_uc002nbk.2_Intron|CYP4F3_uc010xon.1_Intron	NM_000896	NP_000887			cytochrome P450, family 4, subfamily F,						leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3																		---	---	---	---
C19orf44	84167	broad.mit.edu	37	19	16612361	16612361	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16612361C>T	uc002neh.1	+	2	831	c.758C>T	c.(757-759)TCG>TTG	p.S253L	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.S253L|C19orf44_uc002neg.2_Missense_Mutation_p.S253L|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	253											0																		---	---	---	---
ANKLE1	126549	broad.mit.edu	37	19	17396566	17396566	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17396566G>A	uc002nga.2	+	8	1889	c.1613G>A	c.(1612-1614)TGC>TAC	p.C538Y	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Missense_Mutation_p.C534Y|ANKLE1_uc010xpn.1_Intron|ANKLE1_uc002nfy.2_Missense_Mutation_p.C501Y|ANKLE1_uc002nfz.2_Missense_Mutation_p.C244Y	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	538						nuclear envelope					0																		---	---	---	---
ARRDC2	27106	broad.mit.edu	37	19	18120452	18120452	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18120452C>T	uc002nhv.2	+	4	684	c.541C>T	c.(541-543)CGT>TGT	p.R181C	ARRDC2_uc002nhu.2_Missense_Mutation_p.R176C	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	181										pancreas(1)	1																		---	---	---	---
ARRDC2	27106	broad.mit.edu	37	19	18121027	18121027	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18121027C>T	uc002nhv.2	+	6	1015	c.872C>T	c.(871-873)ACG>ATG	p.T291M	ARRDC2_uc002nhu.2_Missense_Mutation_p.T286M	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	291										pancreas(1)	1																		---	---	---	---
PIK3R2	5296	broad.mit.edu	37	19	18279572	18279572	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18279572G>A	uc002nia.1	+	15	2357	c.1845G>A	c.(1843-1845)CCG>CCA	p.P615P	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	615					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6																OREG0025359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KIAA1683	80726	broad.mit.edu	37	19	18375881	18375881	+	Silent	SNP	C	T	T	rs149210128		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18375881C>T	uc002nin.2	-	3	2685	c.2469G>A	c.(2467-2469)CCG>CCA	p.P823P	KIAA1683_uc010ebn.2_Silent_p.P823P|KIAA1683_uc010xqe.1_Silent_p.P777P	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	823						mitochondrion				ovary(2)	2																		---	---	---	---
TMEM59L	25789	broad.mit.edu	37	19	18729233	18729233	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18729233C>T	uc002njy.3	+	7	918	c.831C>T	c.(829-831)TCC>TCT	p.S277S		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	277	Helical; (Potential).					Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4																		---	---	---	---
SFRS14	10147	broad.mit.edu	37	19	19115460	19115460	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19115460G>A	uc002nkx.2	-						SFRS14_uc002nkz.1_Intron|SFRS14_uc002nla.1_Intron|SFRS14_uc002nlb.2_Intron|SFRS14_uc010xqk.1_Intron	NM_014884	NP_055699			splicing factor, arginine/serine-rich 14						mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)															---	---	---	---
NCAN	1463	broad.mit.edu	37	19	19335242	19335242	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19335242G>T	uc002nlz.2	+	5	877	c.778G>T	c.(778-780)GGC>TGC	p.G260C	NCAN_uc010ecc.1_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	260	Link 2.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)															---	---	---	---
TM6SF2	53345	broad.mit.edu	37	19	19375644	19375644	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19375644G>A	uc002nmd.1	-	10	1013	c.963C>T	c.(961-963)CGC>CGT	p.R321R	HAPLN4_uc002nmb.2_5'Flank|HAPLN4_uc002nmc.2_Intron	NM_001001524	NP_001001524	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	321						integral to membrane					0			Epithelial(12;0.0151)															---	---	---	---
GATAD2A	54815	broad.mit.edu	37	19	19606629	19606629	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19606629T>C	uc010xqt.1	+	6	1003	c.691T>C	c.(691-693)TCC>CCC	p.S231P	GATAD2A_uc010xqu.1_Intron|GATAD2A_uc010xqv.1_Missense_Mutation_p.S250P|GATAD2A_uc010xqw.1_Missense_Mutation_p.S58P	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	231					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
ATP13A1	57130	broad.mit.edu	37	19	19767469	19767469	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19767469C>A	uc002nnh.3	-	7	1111	c.1083G>T	c.(1081-1083)AAG>AAT	p.K361N	ATP13A1_uc002nnf.3_5'Flank|ATP13A1_uc002nng.2_Missense_Mutation_p.K243N	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	361	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(3)|large_intestine(2)|central_nervous_system(1)	6																		---	---	---	---
ZNF486	90649	broad.mit.edu	37	19	20308172	20308172	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20308172C>T	uc002nou.2	+	4	710	c.653C>T	c.(652-654)GCC>GTC	p.A218V		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	218	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
ZNF99	7652	broad.mit.edu	37	19	22940245	22940245	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22940245A>G	uc010xrh.1	-	5	2193	c.2193T>C	c.(2191-2193)TGT>TGC	p.C731C		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)																---	---	---	---
ZNF99	7652	broad.mit.edu	37	19	22941839	22941839	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22941839C>T	uc010xrh.1	-	5	599	c.599G>A	c.(598-600)GGC>GAC	p.G200D		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)																---	---	---	---
CHST8	64377	broad.mit.edu	37	19	34263463	34263463	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34263463T>A	uc002nus.3	+	5	1275	c.770T>A	c.(769-771)GTC>GAC	p.V257D	CHST8_uc002nut.3_Missense_Mutation_p.V257D|CHST8_uc002nuu.2_Missense_Mutation_p.V257D	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	257	Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)																	---	---	---	---
KCTD15	79047	broad.mit.edu	37	19	34302308	34302308	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34302308G>A	uc002nuy.3	+	6	812	c.544G>A	c.(544-546)GCA>ACA	p.A182T	KCTD15_uc002nuv.2_Missense_Mutation_p.A182T|KCTD15_uc002nuw.3_Missense_Mutation_p.A182T|KCTD15_uc010xrt.1_Missense_Mutation_p.A182T|KCTD15_uc002nux.3_Missense_Mutation_p.A182T	NM_001129994	NP_001123466	Q96SI1	KCD15_HUMAN	potassium channel tetramerisation domain	182						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
KIAA0355	9710	broad.mit.edu	37	19	34843719	34843719	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34843719C>T	uc002nvd.3	+	14	3931	c.3072C>T	c.(3070-3072)AAC>AAT	p.N1024N		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	1024										ovary(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
NPHS1	4868	broad.mit.edu	37	19	36335025	36335025	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36335025C>T	uc002oby.2	-	16	2192	c.2192G>A	c.(2191-2193)CGG>CAG	p.R731Q		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	731	Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
WDR62	284403	broad.mit.edu	37	19	36590367	36590367	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36590367C>T	uc002odc.2	+	22	2678	c.2587C>T	c.(2587-2589)CGC>TGC	p.R863C	WDR62_uc002odd.2_Missense_Mutation_p.R863C	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	863					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
ZNF829	374899	broad.mit.edu	37	19	37382938	37382938	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37382938C>T	uc002ofa.1	-	6	1117	c.755G>A	c.(754-756)TGC>TAC	p.C252Y	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	252	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
ZNF568	374900	broad.mit.edu	37	19	37441310	37441310	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37441310G>A	uc002ofc.2	+	7	1770	c.1255G>A	c.(1255-1257)GTA>ATA	p.V419I	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.V343I|ZNF568_uc010efe.2_Missense_Mutation_p.V343I|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	419	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
C19orf33	64073	broad.mit.edu	37	19	38795557	38795557	+	Missense_Mutation	SNP	G	A	A	rs58593794		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38795557G>A	uc002ohu.1	+	4	372	c.274G>A	c.(274-276)GAG>AAG	p.E92K	YIF1B_uc002ohw.2_3'UTR|YIF1B_uc002ohx.2_3'UTR|YIF1B_uc010xtx.1_3'UTR|YIF1B_uc010xty.1_3'UTR|YIF1B_uc002oia.2_3'UTR|YIF1B_uc002ohy.2_3'UTR|YIF1B_uc002ohz.2_3'UTR|C19orf33_uc002ohv.1_3'UTR	NM_033520	NP_277055	Q9GZP8	IMUP_HUMAN	HAI-2 related small protein	92						nucleus					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)															---	---	---	---
PSMD8	5714	broad.mit.edu	37	19	38869929	38869929	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38869929C>A	uc002oii.3	+	4	638	c.586C>A	c.(586-588)CTC>ATC	p.L196I	PSMD8_uc010efx.1_Missense_Mutation_p.L29I	NM_002812	NP_002803	P48556	PSMD8_HUMAN	proteasome 26S non-ATPase subunit 8	196					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome regulatory particle	protein binding			central_nervous_system(1)	1	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)															---	---	---	---
RYR1	6261	broad.mit.edu	37	19	39001390	39001390	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39001390G>A	uc002oit.2	+	60	9221	c.9091G>A	c.(9091-9093)GCC>ACC	p.A3031T	RYR1_uc002oiu.2_Missense_Mutation_p.A3031T|RYR1_uc002oiv.1_5'UTR|RYR1_uc010xuf.1_5'Flank	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3031	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
RYR1	6261	broad.mit.edu	37	19	39018400	39018400	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39018400A>G	uc002oit.2	+	73	10930	c.10800A>G	c.(10798-10800)TCA>TCG	p.S3600S	RYR1_uc002oiu.2_Silent_p.S3595S|RYR1_uc002oiv.1_Silent_p.S515S|RYR1_uc010xuf.1_Silent_p.S520S	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3600					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
RINL	126432	broad.mit.edu	37	19	39361401	39361401	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39361401T>C	uc002ojq.2	-	8	879	c.491A>G	c.(490-492)TAC>TGC	p.Y164C	RINL_uc002ojr.1_5'Flank|RINL_uc010xuo.1_Missense_Mutation_p.Y278C	NM_198445	NP_940847	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	164							GTPase activator activity			pancreas(1)	1																		---	---	---	---
NFKBIB	4793	broad.mit.edu	37	19	39399455	39399455	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39399455G>A	uc002ojw.2	+	6	1112	c.1054G>A	c.(1054-1056)GAC>AAC	p.D352N	NFKBIB_uc002ojx.2_3'UTR|NFKBIB_uc002ojy.2_3'UTR	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	352					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40366105	40366105	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40366105G>T	uc002omp.3	-	30	14137	c.14129C>A	c.(14128-14130)CCT>CAT	p.P4710H		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4710						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40366576	40366576	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40366576G>A	uc002omp.3	-							NM_003890	NP_003881			Fc fragment of IgG binding protein precursor							extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40384013	40384013	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40384013G>A	uc002omp.3	-	21	9605	c.9597C>T	c.(9595-9597)GAC>GAT	p.D3199D		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3199	TIL 7.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40395994	40395994	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40395994C>T	uc002omp.3	-	15	7411	c.7403G>A	c.(7402-7404)CGC>CAC	p.R2468H		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2468	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40421347	40421347	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40421347G>T	uc002omp.3	-	5	2582	c.2574C>A	c.(2572-2574)CCC>CCA	p.P858P		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	858						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	41003523	41003523	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41003523G>A	uc002ony.2	+						SPTBN4_uc002onx.2_Intron|SPTBN4_uc002onz.2_Intron	NM_020971	NP_066022			spectrin, beta, non-erythrocytic 4 isoform						actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
POU2F2	5452	broad.mit.edu	37	19	42599459	42599459	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42599459C>T	uc002osp.2	-	11	1177	c.1110G>A	c.(1108-1110)CCG>CCA	p.P370P	POU2F2_uc002osn.2_Silent_p.P354P|POU2F2_uc002oso.2_Silent_p.P143P|POU2F2_uc002osq.2_Silent_p.P354P|POU2F2_uc002osr.1_Silent_p.P370P	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	370					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)																---	---	---	---
GSK3A	2931	broad.mit.edu	37	19	42736197	42736197	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42736197G>A	uc002otb.1	-						GSK3A_uc002ota.1_Intron|GSK3A_uc002otc.2_Intron	NM_019884	NP_063937			glycogen synthase kinase 3 alpha						insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			ovary(2)|lung(2)	4		Prostate(69;0.00682)																---	---	---	---
CD177	57126	broad.mit.edu	37	19	43866334	43866334	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43866334G>A	uc002owi.2	+	10	1218	c.1176G>A	c.(1174-1176)GCG>GCA	p.A392A	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	392					blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)																---	---	---	---
XRCC1	7515	broad.mit.edu	37	19	44057634	44057634	+	Missense_Mutation	SNP	G	A	A	rs143266865		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44057634G>A	uc002owt.2	-	6	640	c.520C>T	c.(520-522)CGT>TGT	p.R174C	XRCC1_uc010xwp.1_Missense_Mutation_p.R143C	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	174					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)											Other_BER_factors					---	---	---	---
CADM4	199731	broad.mit.edu	37	19	44130298	44130298	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44130298C>T	uc002oxc.1	-	5	691	c.642G>A	c.(640-642)ACG>ACA	p.T214T		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	214	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane					0		Prostate(69;0.0199)																---	---	---	---
C19orf61	56006	broad.mit.edu	37	19	44237772	44237772	+	Intron	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44237772C>A	uc002oxj.2	-						C19orf61_uc002oxk.2_Intron	NM_019108	NP_061981			SMG9 protein						nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)																---	---	---	---
ZNF227	7770	broad.mit.edu	37	19	44739650	44739650	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44739650A>G	uc002oyu.2	+	6	1272	c.1067A>G	c.(1066-1068)GAA>GGA	p.E356G	ZNF227_uc010xwu.1_Missense_Mutation_p.E305G|ZNF227_uc002oyv.2_Missense_Mutation_p.E356G|ZNF227_uc010xwv.1_Missense_Mutation_p.E305G|ZNF227_uc010xww.1_Missense_Mutation_p.E277G|ZNF227_uc002oyw.2_Missense_Mutation_p.E328G|ZNF227_uc010ejh.2_Missense_Mutation_p.E349G|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	356	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)																---	---	---	---
RTN2	6253	broad.mit.edu	37	19	45997462	45997462	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45997462G>A	uc002pcb.2	-	4	1004	c.776C>T	c.(775-777)ACG>ATG	p.T259M	RTN2_uc002pcc.2_Missense_Mutation_p.T259M|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	259						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)														---	---	---	---
OPA3	80207	broad.mit.edu	37	19	46057131	46057131	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46057131T>C	uc002pck.3	-	2	281	c.181A>G	c.(181-183)ATG>GTG	p.M61V	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Missense_Mutation_p.M8V	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	61					response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)														---	---	---	---
FOXA3	3171	broad.mit.edu	37	19	46375340	46375340	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46375340C>T	uc002pdr.2	+	2	274	c.77C>T	c.(76-78)TCG>TTG	p.S26L		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	26					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)														---	---	---	---
ZC3H4	23211	broad.mit.edu	37	19	47572412	47572412	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47572412C>G	uc002pga.3	-	14	2373	c.2335G>C	c.(2335-2337)GAG>CAG	p.E779Q	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	779	Potential.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)														---	---	---	---
TMEM143	55260	broad.mit.edu	37	19	48845826	48845826	+	Silent	SNP	C	T	T	rs138171230		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48845826C>T	uc002pix.1	-	6	945	c.936G>A	c.(934-936)CTG>CTA	p.L312L	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Silent_p.L277L|TMEM143_uc010xzn.1_Silent_p.L247L|TMEM143_uc010elw.1_Silent_p.L212L|TMEM143_uc010xzo.1_Silent_p.L102L	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	312	Helical; (Potential).					integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)														---	---	---	---
SYNGR4	23546	broad.mit.edu	37	19	48879533	48879533	+	Silent	SNP	C	T	T	rs149839356		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48879533C>T	uc002piz.2	+	5	908	c.663C>T	c.(661-663)ACC>ACT	p.T221T		NM_012451	NP_036583	O95473	SNG4_HUMAN	synaptogyrin 4	221						integral to membrane					0		all_epithelial(76;5.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|Prostate(7;0.0143)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)														---	---	---	---
FGF21	26291	broad.mit.edu	37	19	49261364	49261364	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49261364G>A	uc002pkn.1	+	4	1089	c.517G>A	c.(517-519)GCA>ACA	p.A173T	FUT1_uc002pkk.2_5'Flank|FUT1_uc002pkm.1_5'Flank|FGF21_uc002pko.1_Missense_Mutation_p.A173T	NM_019113	NP_061986	Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21 precursor	173					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)														---	---	---	---
GYS1	2997	broad.mit.edu	37	19	49481210	49481210	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49481210T>C	uc002plp.2	-	10	1520	c.1279A>G	c.(1279-1281)ATG>GTG	p.M427V	GYS1_uc010xzy.1_Missense_Mutation_p.M60V|GYS1_uc010emm.2_Missense_Mutation_p.M363V|GYS1_uc010xzz.1_Missense_Mutation_p.M347V|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	427					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)														---	---	---	---
KCNA7	3743	broad.mit.edu	37	19	49575336	49575336	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49575336G>A	uc002pmg.2	-	1	863	c.507C>T	c.(505-507)CGC>CGT	p.R169R		NM_031886	NP_114092	Q96RP8	KCNA7_HUMAN	potassium voltage-gated channel, shaker-related	169						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)	1		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000397)|OV - Ovarian serous cystadenocarcinoma(262;0.000519)|GBM - Glioblastoma multiforme(486;0.00541)|Epithelial(262;0.0441)														---	---	---	---
ALDH16A1	126133	broad.mit.edu	37	19	49971789	49971789	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49971789C>T	uc002pnt.2	+	15	2206	c.2090C>T	c.(2089-2091)GCG>GTG	p.A697V	ALDH16A1_uc010yar.1_Missense_Mutation_p.A646V|ALDH16A1_uc010yas.1_Missense_Mutation_p.A532V|ALDH16A1_uc010yat.1_Missense_Mutation_p.A534V	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	697							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)														---	---	---	---
AP2A1	160	broad.mit.edu	37	19	50305853	50305853	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50305853C>T	uc002ppn.2	+	16	2388	c.2177C>T	c.(2176-2178)GCT>GTT	p.A726V	AP2A1_uc010enj.1_Intron|AP2A1_uc002ppo.2_Intron|AP2A1_uc002ppp.1_3'UTR|AP2A1_uc010enk.2_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	726					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)														---	---	---	---
MYBPC2	4606	broad.mit.edu	37	19	50957409	50957409	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50957409G>A	uc002psf.2	+	17	1933	c.1882G>A	c.(1882-1884)GTG>ATG	p.V628M		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	628	Ig-like C2-type 5.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)														---	---	---	---
SIGLEC8	27181	broad.mit.edu	37	19	51955642	51955642	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51955642G>A	uc002pwt.2	-	7	1558	c.1491C>T	c.(1489-1491)GTC>GTT	p.V497V	SIGLEC8_uc010yda.1_Silent_p.V388V|SIGLEC8_uc002pwu.2_Intron|SIGLEC8_uc010eox.2_Silent_p.V404V	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	497	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)														---	---	---	---
PPP2R1A	5518	broad.mit.edu	37	19	52716250	52716250	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52716250G>A	uc002pyp.2	+	6	853	c.694G>A	c.(694-696)GCC>ACC	p.A232T	PPP2R1A_uc010ydk.1_Missense_Mutation_p.A177T|PPP2R1A_uc010epm.1_Missense_Mutation_p.A272T|PPP2R1A_uc002pyq.2_Missense_Mutation_p.A53T	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	232	PP2A subunit B binding.|SV40 small T antigen binding.|HEAT 6.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)				Mis		clear cell ovarian carcinoma								---	---	---	---
NLRP12	91662	broad.mit.edu	37	19	54327438	54327438	+	Translation_Start_Site	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54327438G>A	uc002qch.3	-	1	211	c.-9C>T	c.(-11--7)CACGG>CATGG		NLRP12_uc002qci.3_Translation_Start_Site|NLRP12_uc002qcj.3_Translation_Start_Site|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Translation_Start_Site	NM_144687	NP_653288			NLR family, pyrin domain containing 12 isoform						negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)														---	---	---	---
LILRA3	11026	broad.mit.edu	37	19	54803758	54803758	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54803758A>G	uc002qfd.2	-						LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856			leukocyte immunoglobulin-like receptor,						defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)														---	---	---	---
LENG8	114823	broad.mit.edu	37	19	54968979	54968979	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54968979C>T	uc002qfv.1	+	11	1818	c.1674C>T	c.(1672-1674)GAC>GAT	p.D558D	LENG8_uc002qfw.2_Silent_p.D595D			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	558							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)														---	---	---	---
LILRB1	10859	broad.mit.edu	37	19	55148105	55148105	+	Splice_Site	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55148105T>A	uc002qgj.2	+	15	2146	c.1806_splice	c.e15+2	p.E602_splice	LILRB1_uc002qgl.2_Splice_Site_p.E603_splice|LILRB1_uc002qgk.2_Splice_Site_p.E603_splice|LILRB1_uc002qgm.2_Splice_Site_p.E604_splice|LILRB1_uc010erq.2_Splice_Site_p.E586_splice|LILRB1_uc010err.2_Splice_Site	NM_006669	NP_006660			leukocyte immunoglobulin-like receptor,						regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)											HNSCC(37;0.09)			---	---	---	---
NLRP11	204801	broad.mit.edu	37	19	56303675	56303675	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56303675C>A	uc010ygf.1	-	9	3216	c.2505G>T	c.(2503-2505)GAG>GAT	p.E835D	NLRP11_uc002qlz.2_Missense_Mutation_p.E682D|NLRP11_uc002qmb.2_Missense_Mutation_p.E736D|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	835							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)														---	---	---	---
ZNF71	58491	broad.mit.edu	37	19	57133765	57133765	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57133765G>A	uc002qnm.3	+	3	1348	c.1110G>A	c.(1108-1110)ACG>ACA	p.T370T		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	370	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)														---	---	---	---
ZNF211	10520	broad.mit.edu	37	19	58152147	58152147	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58152147G>T	uc002qpq.2	+	3	473	c.293G>T	c.(292-294)AGG>ATG	p.R98M	ZNF211_uc010yhb.1_Missense_Mutation_p.R102M|ZNF211_uc002qpp.2_Missense_Mutation_p.R111M|ZNF211_uc002qpr.2_Missense_Mutation_p.R162M|ZNF211_uc002qps.2_Missense_Mutation_p.R163M|ZNF211_uc002qpt.2_Missense_Mutation_p.R110M|ZNF211_uc010yhc.1_Missense_Mutation_p.R110M|ZNF211_uc010yhd.1_Missense_Mutation_p.R37M|ZNF211_uc010yhe.1_Missense_Mutation_p.R89M	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	98	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZSCAN22	342945	broad.mit.edu	37	19	58850593	58850593	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58850593G>T	uc002qsc.2	+	3	1524	c.1377G>T	c.(1375-1377)ACG>ACT	p.T459T	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	459					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)														---	---	---	---
ZNF446	55663	broad.mit.edu	37	19	58992029	58992029	+	Missense_Mutation	SNP	G	A	A	rs142233722	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58992029G>A	uc002qsz.2	+	7	1406	c.1289G>A	c.(1288-1290)CGC>CAC	p.R430H	ZNF446_uc002qta.2_3'UTR|ZNF446_uc010eur.2_3'UTR|SLC27A5_uc002qtb.2_RNA	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	430	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
CSNK2A1	1457	broad.mit.edu	37	20	472991	472991	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:472991C>A	uc002wdw.1	-	9	921	c.528G>T	c.(526-528)TGG>TGT	p.W176C	CSNK2A1_uc002wdx.1_Missense_Mutation_p.W176C|CSNK2A1_uc002wdy.1_Missense_Mutation_p.W40C	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	176	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)															---	---	---	---
C20orf54	113278	broad.mit.edu	37	20	745873	745873	+	Silent	SNP	C	T	T	rs139965967	byFrequency	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:745873C>T	uc002wed.3	-	2	885	c.546G>A	c.(544-546)ACG>ACA	p.T182T	C20orf54_uc002wee.2_Silent_p.T182T	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	182					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2																		---	---	---	---
IDH3B	3420	broad.mit.edu	37	20	2641132	2641132	+	Missense_Mutation	SNP	C	A	A	rs114253155	byFrequency;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2641132C>A	uc002wgp.2	-	7	645	c.636G>T	c.(634-636)AAG>AAT	p.K212N	IDH3B_uc002wgq.2_Missense_Mutation_p.K212N|IDH3B_uc002wgr.2_Missense_Mutation_p.K60N|IDH3B_uc010zpz.1_3'UTR	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	212					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)													---	---	---	---
VPS16	64601	broad.mit.edu	37	20	2840753	2840753	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2840753C>A	uc002whe.2	+	3	244	c.196C>A	c.(196-198)CTC>ATC	p.L66I	VPS16_uc002whh.2_5'Flank|VPS16_uc002whf.2_Missense_Mutation_p.L66I|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	66					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
PTPRA	5786	broad.mit.edu	37	20	2969091	2969091	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2969091G>A	uc010zqd.1	+	8	1059	c.742G>A	c.(742-744)GAC>AAC	p.D248N	PTPRA_uc002whj.2_Missense_Mutation_p.D237N|PTPRA_uc010zqc.1_Missense_Mutation_p.D122N|PTPRA_uc002whk.2_Missense_Mutation_p.D228N|PTPRA_uc002whl.2_Missense_Mutation_p.D228N|PTPRA_uc002whm.2_Missense_Mutation_p.D4N|PTPRA_uc002whn.2_Missense_Mutation_p.D228N|PTPRA_uc002who.2_5'UTR	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	237	Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
C20orf27	54976	broad.mit.edu	37	20	3739177	3739177	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3739177A>G	uc002wji.1	-						C20orf27_uc002wjf.1_Intron|C20orf27_uc002wjh.1_Intron	NM_001039140	NP_001034229			hypothetical protein LOC54976												0																		---	---	---	---
MAVS	57506	broad.mit.edu	37	20	3838363	3838363	+	Missense_Mutation	SNP	G	A	A	rs142867936		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3838363G>A	uc002wjw.3	+	3	368	c.199G>A	c.(199-201)GGC>AGC	p.G67S	MAVS_uc002wjv.2_Missense_Mutation_p.G67S|MAVS_uc010zqn.1_Missense_Mutation_p.G67S|MAVS_uc002wjx.3_Intron|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	67	Cytoplasmic (Probable).|Required for interaction with NLRX1.|CARD.			GWV->AAA: Impairs ability to induce IFN- beta.	activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0																		---	---	---	---
PRNP	5621	broad.mit.edu	37	20	4680115	4680115	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:4680115G>A	uc002wku.2	+	2	612	c.249G>A	c.(247-249)CAG>CAA	p.Q83Q	PRNP_uc002wkv.2_Silent_p.Q83Q|PRNP_uc002wkw.2_Silent_p.Q83Q|PRNP_uc002wkx.2_Silent_p.Q83Q|PRNP_uc002wkt.1_Silent_p.Q83Q|PRNP_uc002wky.2_Silent_p.Q83Q|PRNP_uc010gbe.1_Silent_p.Q83Q	NM_001080122	NP_001073591	P04156	PRIO_HUMAN	prion protein preproprotein	83	Interaction with GRB2, ERI3 and SYN1 (By similarity).|5 X 8 AA tandem repeats of P-H-G-G-G-W-G- Q.|4.				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(1)	1					Tetracycline(DB00759)													---	---	---	---
PRND	23627	broad.mit.edu	37	20	4705306	4705306	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:4705306C>T	uc002wkz.2	+	2	180	c.109C>T	c.(109-111)CGG>TGG	p.R37W		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	37	Flexible tail.				protein homooligomerization	anchored to membrane|plasma membrane					0																		---	---	---	---
GPCPD1	56261	broad.mit.edu	37	20	5579450	5579450	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5579450A>G	uc002wme.3	-	3	280	c.67T>C	c.(67-69)TGT>CGT	p.C23R		NM_019593	NP_062539	Q9NPB8	GPCP1_HUMAN	hypothetical protein LOC56261	23	CBM20.				glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0																		---	---	---	---
PLCB4	5332	broad.mit.edu	37	20	9438112	9438112	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:9438112G>A	uc002wnf.2	+	32	3148	c.3012G>A	c.(3010-3012)ACG>ACA	p.T1004T	PLCB4_uc010gbw.1_Silent_p.T1004T|PLCB4_uc010gbx.2_Silent_p.T1016T|PLCB4_uc002wne.2_Silent_p.T1004T|PLCB4_uc002wnh.2_Silent_p.T851T	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	1004					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15																		---	---	---	---
JAG1	182	broad.mit.edu	37	20	10620610	10620610	+	Intron	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10620610G>A	uc002wnw.2	-							NM_000214	NP_000205			jagged 1 precursor						angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9														Alagille_Syndrome				---	---	---	---
TASP1	55617	broad.mit.edu	37	20	13463963	13463963	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13463963C>T	uc002woi.2	-	11	1013	c.896G>A	c.(895-897)CGC>CAC	p.R299H	TASP1_uc010zri.1_RNA|TASP1_uc002woh.2_Missense_Mutation_p.R276H|TASP1_uc010zrj.1_RNA	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	299					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0																		---	---	---	---
HM13	81502	broad.mit.edu	37	20	30126018	30126018	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30126018A>G	uc002wwe.2	+	3	433	c.319A>G	c.(319-321)ATG>GTG	p.M107V	HM13_uc002wwc.2_Missense_Mutation_p.M107V|HM13_uc002wwd.2_Missense_Mutation_p.M107V|HM13_uc002wwb.1_Missense_Mutation_p.M107V	NM_030789	NP_110416	Q8TCT9	HM13_HUMAN	minor histocompatibility antigen 13 isoform 1	107	Helical; (Potential).				membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)	1	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)															---	---	---	---
TTLL9	164395	broad.mit.edu	37	20	30521638	30521638	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30521638T>C	uc010gdx.1	+	11	1037	c.784T>C	c.(784-786)TCT>CCT	p.S262P	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Missense_Mutation_p.S164P|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	262	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)															---	---	---	---
KIF3B	9371	broad.mit.edu	37	20	30904022	30904022	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30904022C>T	uc002wxq.2	+	3	1573	c.1406C>T	c.(1405-1407)GCC>GTC	p.A469V	KIF3B_uc010ztw.1_Missense_Mutation_p.A407V	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	469	Potential.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
ZNF341	84905	broad.mit.edu	37	20	32332958	32332958	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32332958G>A	uc002wzy.2	+	3	212	c.192G>A	c.(190-192)TCG>TCA	p.S64S	ZNF341_uc002wzx.2_Silent_p.S64S|ZNF341_uc010geq.2_Intron|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	64	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
NCOA6	23054	broad.mit.edu	37	20	33342667	33342667	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33342667C>T	uc002xav.2	-	9	4104	c.1533G>A	c.(1531-1533)ATG>ATA	p.M511I	NCOA6_uc002xaw.2_Missense_Mutation_p.M511I	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	511	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7																		---	---	---	---
CPNE1	8904	broad.mit.edu	37	20	34218826	34218826	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34218826T>C	uc002xdf.2	-	13	1355	c.992A>G	c.(991-993)GAC>GGC	p.D331G	CPNE1_uc002xdc.2_5'UTR|CPNE1_uc010zvj.1_Missense_Mutation_p.D336G|CPNE1_uc002xde.2_Missense_Mutation_p.D307G|CPNE1_uc002xdg.2_Missense_Mutation_p.D331G|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.D331G|CPNE1_uc002xdi.2_Missense_Mutation_p.D331G|CPNE1_uc002xdj.2_Missense_Mutation_p.D331G|CPNE1_uc002xdk.2_Missense_Mutation_p.D331G|CPNE1_uc002xdl.2_Missense_Mutation_p.D331G|CPNE1_uc002xdm.2_Missense_Mutation_p.D331G|CPNE1_uc010gfk.1_3'UTR	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	331	VWFA.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)															---	---	---	---
C20orf117	140710	broad.mit.edu	37	20	35433186	35433186	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35433186C>A	uc002xgd.1	-	10	2652	c.2325G>T	c.(2323-2325)AAG>AAT	p.K775N	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	775											0		Myeloproliferative disorder(115;0.00874)																---	---	---	---
RPRD1B	58490	broad.mit.edu	37	20	36686021	36686021	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:36686021A>G	uc002xho.3	+	4	905	c.503A>G	c.(502-504)CAG>CGG	p.Q168R		NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	168										pancreas(1)	1																OREG0025919	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SLC32A1	140679	broad.mit.edu	37	20	37356284	37356284	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37356284T>G	uc002xjc.2	+	2	843	c.580T>G	c.(580-582)TGC>GGC	p.C194G		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	194	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)													---	---	---	---
CHD6	84181	broad.mit.edu	37	20	40102126	40102126	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40102126G>A	uc002xka.1	-	17	2678	c.2500C>T	c.(2500-2502)CGG>TGG	p.R834W	CHD6_uc002xkd.2_Missense_Mutation_p.R812W	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	834	Helicase C-terminal.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)																---	---	---	---
PTPRT	11122	broad.mit.edu	37	20	40713354	40713354	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40713354G>A	uc002xkg.2	-	29	4288	c.4104C>T	c.(4102-4104)GAC>GAT	p.D1368D	PTPRT_uc010ggj.2_Silent_p.D1387D|PTPRT_uc010ggi.2_Silent_p.D571D	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1368	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)																---	---	---	---
PTPRT	11122	broad.mit.edu	37	20	40747077	40747077	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40747077A>G	uc002xkg.2	-	21	3132	c.2948T>C	c.(2947-2949)ATC>ACC	p.I983T	PTPRT_uc010ggj.2_Missense_Mutation_p.I1002T|PTPRT_uc010ggi.2_Missense_Mutation_p.I186T	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	983	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)																---	---	---	---
MYBL2	4605	broad.mit.edu	37	20	42320791	42320791	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:42320791C>T	uc002xlb.1	+						MYBL2_uc010zwj.1_Intron|MYBL2_uc002xla.1_Intron	NM_002466	NP_002457			MYB-related protein B							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)															---	---	---	---
TOX2	84969	broad.mit.edu	37	20	42574682	42574682	+	Intron	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:42574682A>C	uc002xlf.3	+						TOX2_uc010ggo.2_Intron|TOX2_uc002xle.3_Intron|TOX2_uc010ggp.2_Intron	NM_001098798	NP_001092268			TOX high mobility group box family member 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)															---	---	---	---
WISP2	8839	broad.mit.edu	37	20	43355865	43355865	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43355865C>T	uc002xmn.2	+	5	1023	c.670C>T	c.(670-672)CGA>TGA	p.R224*	uc002xml.1_Intron|uc002xmm.1_Intron|WISP2_uc002xmp.2_Nonsense_Mutation_p.R224*|WISP2_uc002xmq.2_Silent_p.A141A	NM_003881	NP_003872	O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	224	TSP type-1.				cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
PABPC1L	80336	broad.mit.edu	37	20	43566708	43566708	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43566708G>A	uc010ggv.1	+	13	1734	c.1652G>A	c.(1651-1653)CGT>CAT	p.R551H	PABPC1L_uc010zwq.1_RNA|PABPC1L_uc002xmv.2_RNA|PABPC1L_uc002xmw.2_Missense_Mutation_p.R105H|PABPC1L_uc002xmx.2_Missense_Mutation_p.R105H	NM_001124756	NP_001118228	Q4VXU2	PAP1L_HUMAN	poly(A)-binding protein, cytoplasmic 1-like	551	PABC.						nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
KCNS1	3787	broad.mit.edu	37	20	43727255	43727255	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43727255C>T	uc002xnc.2	-	4	555	c.158G>A	c.(157-159)CGC>CAC	p.R53H	KCNS1_uc002xnd.2_Missense_Mutation_p.R53H	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	53	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)																---	---	---	---
SLC2A10	81031	broad.mit.edu	37	20	45354636	45354636	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45354636G>A	uc002xsl.2	+	2	1058	c.961G>A	c.(961-963)GTG>ATG	p.V321M		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	321	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
NCOA3	8202	broad.mit.edu	37	20	46251037	46251037	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:46251037C>T	uc002xtk.2	+	3	251	c.46C>T	c.(46-48)CGA>TGA	p.R16*	NCOA3_uc010ght.1_Nonsense_Mutation_p.R16*|NCOA3_uc002xtl.2_Nonsense_Mutation_p.R16*|NCOA3_uc002xtm.2_Nonsense_Mutation_p.R16*|NCOA3_uc002xtn.2_Nonsense_Mutation_p.R16*	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	16					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5																		---	---	---	---
ARFGEF2	10564	broad.mit.edu	37	20	47630223	47630223	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47630223A>G	uc002xtx.3	+	29	4193	c.4041A>G	c.(4039-4041)GTA>GTG	p.V1347V	ARFGEF2_uc010zyf.1_Silent_p.V640V	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1347					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)															---	---	---	---
ZNFX1	57169	broad.mit.edu	37	20	47886982	47886982	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47886982A>G	uc002xui.2	-	3	1614	c.1367T>C	c.(1366-1368)ATG>ACG	p.M456T		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	456							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)															---	---	---	---
NFATC2	4773	broad.mit.edu	37	20	50133480	50133480	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50133480G>A	uc002xwd.2	-	3	1395	c.1175C>T	c.(1174-1176)GCA>GTA	p.A392V	NFATC2_uc002xwc.2_Missense_Mutation_p.A392V|NFATC2_uc010zyv.1_Missense_Mutation_p.A173V|NFATC2_uc010zyw.1_Missense_Mutation_p.A173V|NFATC2_uc010zyx.1_Missense_Mutation_p.A372V|NFATC2_uc010zyy.1_Missense_Mutation_p.A173V|NFATC2_uc010zyz.1_Missense_Mutation_p.A173V|NFATC2_uc002xwe.2_Missense_Mutation_p.A372V	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	392	RHD.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)																	---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50769032	50769032	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50769032G>A	uc002xwl.2	-	6	2048	c.1699C>T	c.(1699-1701)CCG>TCG	p.P567S	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Missense_Mutation_p.P565S|ZFP64_uc002xwn.2_Missense_Mutation_p.P513S	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	567					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50769441	50769441	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50769441G>A	uc002xwl.2	-	6	1639	c.1290C>T	c.(1288-1290)TGC>TGT	p.C430C	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Silent_p.C428C|ZFP64_uc002xwn.2_Silent_p.C376C	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	430	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
BCAS1	8537	broad.mit.edu	37	20	52645024	52645024	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:52645024G>A	uc002xws.2	-	4	968	c.630C>T	c.(628-630)GAC>GAT	p.D210D	BCAS1_uc010zzb.1_Silent_p.D113D|BCAS1_uc010gim.2_Silent_p.D113D|BCAS1_uc002xwt.2_Silent_p.D210D|BCAS1_uc010gil.1_Silent_p.D210D|BCAS1_uc010zzc.1_Silent_p.D113D	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	210						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)															---	---	---	---
MC3R	4159	broad.mit.edu	37	20	54824345	54824345	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:54824345C>T	uc002xxb.2	+	1	558	c.446C>T	c.(445-447)GCG>GTG	p.A149V		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	186	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)															---	---	---	---
CTSZ	1522	broad.mit.edu	37	20	57571762	57571762	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57571762C>T	uc002yai.2	-	5	859	c.733G>A	c.(733-735)GTG>ATG	p.V245M	CTSZ_uc002yaj.3_Missense_Mutation_p.V245M	NM_001336	NP_001327	Q9UBR2	CATZ_HUMAN	cathepsin Z preproprotein	245					proteolysis	endoplasmic reticulum|extracellular space|lysosome	cysteine-type endopeptidase activity			kidney(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)															---	---	---	---
ZNF831	128611	broad.mit.edu	37	20	57766684	57766684	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57766684T>A	uc002yan.2	+	1	610	c.610T>A	c.(610-612)TCA>ACA	p.S204T		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	204						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)																	---	---	---	---
PHACTR3	116154	broad.mit.edu	37	20	58348477	58348477	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58348477A>G	uc002yau.2	+	6	1362	c.895A>G	c.(895-897)AGG>GGG	p.R299G	PHACTR3_uc002yat.2_Missense_Mutation_p.R296G|PHACTR3_uc010zzw.1_Missense_Mutation_p.R258G|PHACTR3_uc002yav.2_Missense_Mutation_p.R258G|PHACTR3_uc002yaw.2_Missense_Mutation_p.R258G|PHACTR3_uc002yax.2_Missense_Mutation_p.R188G	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	299						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)															---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58457178	58457178	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58457178A>C	uc002yaz.2	-	26	2711	c.2572T>G	c.(2572-2574)TTT>GTT	p.F858V		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	858					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58490556	58490556	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58490556C>T	uc002yaz.2	-	8	702	c.563G>A	c.(562-564)CGG>CAG	p.R188Q	SYCP2_uc010gju.1_Missense_Mutation_p.R89Q	NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	188					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
C20orf177	63939	broad.mit.edu	37	20	58519297	58519297	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58519297C>T	uc002yba.2	+	5	714	c.299C>T	c.(298-300)TCG>TTG	p.S100L	C20orf177_uc010zzx.1_Intron|C20orf177_uc002ybc.2_Missense_Mutation_p.S100L	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	100										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)															---	---	---	---
OGFR	11054	broad.mit.edu	37	20	61441914	61441914	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61441914C>T	uc002ydj.2	+	5	497	c.462C>T	c.(460-462)GTC>GTT	p.V154V	OGFR_uc002ydk.2_Silent_p.V137V|OGFR_uc002ydl.2_Silent_p.V102V	NM_007346	NP_031372	Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	154					regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity				0	Breast(26;3.65e-08)																	---	---	---	---
C20orf11	54994	broad.mit.edu	37	20	61576265	61576265	+	3'UTR	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61576265C>T	uc002ydy.2	+	5						NM_017896	NP_060366			chromosome 20 open reading frame 11							nucleus	protein binding				0	Breast(26;5.68e-08)																	---	---	---	---
KCNQ2	3785	broad.mit.edu	37	20	62065268	62065268	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62065268A>G	uc002yey.1	-						KCNQ2_uc002yez.1_Intron|KCNQ2_uc002yfa.1_Intron|KCNQ2_uc002yfb.1_Intron|KCNQ2_uc011aax.1_Intron|KCNQ2_uc002yfc.1_Intron	NM_172107	NP_742105			potassium voltage-gated channel KQT-like protein						axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)													---	---	---	---
PRIC285	85441	broad.mit.edu	37	20	62203577	62203577	+	Silent	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62203577G>T	uc002yfm.2	-	2	1054	c.162C>A	c.(160-162)GCC>GCA	p.A54A	PRIC285_uc002yfn.2_Silent_p.A54A	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	54	C2H2-type; atypical.				cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)															---	---	---	---
SLC2A4RG	56731	broad.mit.edu	37	20	62373487	62373487	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62373487C>T	uc002ygq.2	+	5	639	c.584C>T	c.(583-585)CCG>CTG	p.P195L	SLC2A4RG_uc002ygr.2_Missense_Mutation_p.P90L|SLC2A4RG_uc011abj.1_Missense_Mutation_p.P90L|SLC2A4RG_uc002ygs.2_5'UTR|SLC2A4RG_uc002ygt.2_5'UTR	NM_020062	NP_064446	Q9NR83	S2A4R_HUMAN	SLC2A4 regulator	195						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)																	---	---	---	---
OPRL1	4987	broad.mit.edu	37	20	62729726	62729726	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62729726C>T	uc002yic.2	+	5	1089	c.687C>T	c.(685-687)CTC>CTT	p.L229L	OPRL1_uc002yid.2_Silent_p.L229L|OPRL1_uc002yif.3_Silent_p.L224L	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	229	Helical; Name=5; (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)																	---	---	---	---
NRIP1	8204	broad.mit.edu	37	21	16339612	16339612	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:16339612A>G	uc002yjx.2	-	4	1500	c.902T>C	c.(901-903)ATG>ACG	p.M301T		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	301	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)														---	---	---	---
MRPL39	54148	broad.mit.edu	37	21	26979736	26979736	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:26979736G>A	uc002ylo.2	-	1	66	c.52C>T	c.(52-54)CCC>TCC	p.P18S	MRPL39_uc002yln.2_Missense_Mutation_p.P18S	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	18						mitochondrial ribosome	nucleotide binding				0																OREG0026146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ADAMTS5	11096	broad.mit.edu	37	21	28338229	28338229	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28338229G>A	uc002ymg.2	-	1	1211	c.482C>T	c.(481-483)GCG>GTG	p.A161V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	161					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
IFNAR2	3455	broad.mit.edu	37	21	34635606	34635606	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34635606C>T	uc002yrd.2	+	9	1677	c.1349C>T	c.(1348-1350)TCG>TTG	p.S450L	IFNAR2_uc002yre.2_Missense_Mutation_p.S450L|IFNAR2_uc002yrf.2_3'UTR|IL10RB_uc002yrh.1_Intron|IL10RB_uc002yri.1_Intron	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	450	Cytoplasmic (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)													---	---	---	---
IFNAR1	3454	broad.mit.edu	37	21	34726001	34726001	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34726001C>T	uc002yrn.2	+	10	1499	c.1352C>T	c.(1351-1353)CCG>CTG	p.P451L	IFNAR1_uc011adv.1_Missense_Mutation_p.P382L	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	451	Helical; (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)													---	---	---	---
DOPEY2	9980	broad.mit.edu	37	21	37583892	37583892	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37583892T>C	uc002yvg.2	+	6	802	c.723T>C	c.(721-723)CTT>CTC	p.L241L	DOPEY2_uc011aeb.1_Silent_p.L241L	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	241					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
IGSF5	150084	broad.mit.edu	37	21	41151197	41151197	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:41151197G>A	uc002yyo.2	+	5	1002	c.899G>A	c.(898-900)TGC>TAC	p.C300Y		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	300	Cytoplasmic (Potential).|Cys-rich.					integral to membrane|tight junction					0		Prostate(19;5.35e-06)																---	---	---	---
RIPK4	54101	broad.mit.edu	37	21	43161140	43161140	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43161140G>T	uc002yzn.1	-	8	2261	c.2213C>A	c.(2212-2214)GCG>GAG	p.A738E		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	738						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7																		---	---	---	---
C21orf29	54084	broad.mit.edu	37	21	45928803	45928803	+	Intron	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45928803A>G	uc002zfe.1	-						C21orf29_uc010gpv.1_Intron	NM_144991	NP_659428			chromosome 21 open reading frame 29 precursor						cell adhesion	extracellular region	structural molecule activity				0																		---	---	---	---
COL6A2	1292	broad.mit.edu	37	21	47537842	47537842	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47537842G>T	uc002zia.1	+	12	1190	c.1108G>T	c.(1108-1110)GGC>TGC	p.G370C	COL6A2_uc002zhy.1_Missense_Mutation_p.G370C|COL6A2_uc002zhz.1_Missense_Mutation_p.G370C|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	370	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)														---	---	---	---
C21orf56	84221	broad.mit.edu	37	21	47581501	47581501	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47581501G>A	uc011afu.1	-	5	1877	c.815C>T	c.(814-816)CCG>CTG	p.P272L	C21orf56_uc002zii.2_Missense_Mutation_p.P118L	NM_001142854	NP_001136326	Q9H0A9	CU056_HUMAN	hypothetical protein LOC84221 isoform 1	272							protein binding			skin(1)	1	Breast(49;0.214)			Colorectal(79;0.241)														---	---	---	---
PRMT2	3275	broad.mit.edu	37	21	48071777	48071777	+	Intron	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:48071777C>T	uc002zjx.2	+						PRMT2_uc002zjw.2_Intron|PRMT2_uc002zjy.2_Intron|PRMT2_uc010gqm.2_Intron|PRMT2_uc011aga.1_Intron|PRMT2_uc011agb.1_Intron|PRMT2_uc011agc.1_Intron|PRMT2_uc002zjz.1_Intron	NM_206962	NP_996845			HMT1 hnRNP methyltransferase-like 1						developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			ovary(1)	1	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)														---	---	---	---
ARVCF	421	broad.mit.edu	37	22	19960499	19960499	+	Missense_Mutation	SNP	C	A	A	rs114971216	byFrequency;by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19960499C>A	uc002zqz.2	-	15	2770	c.2499G>T	c.(2497-2499)AAG>AAT	p.K833N	ARVCF_uc002zqy.2_Missense_Mutation_p.K349N	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	833					cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)																	---	---	---	---
ARVCF	421	broad.mit.edu	37	22	19965533	19965533	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19965533G>A	uc002zqz.2	-	8	1917	c.1646C>T	c.(1645-1647)GCG>GTG	p.A549V	ARVCF_uc002zqy.2_Missense_Mutation_p.A71V	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	549	ARM 5.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)																	---	---	---	---
PI4KA	5297	broad.mit.edu	37	22	21098990	21098990	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21098990G>A	uc002zsz.3	-	30	3439	c.3208C>T	c.(3208-3210)CGC>TGC	p.R1070C		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1070					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding	p.R1070L(1)		lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)															---	---	---	---
SERPIND1	3053	broad.mit.edu	37	22	21134357	21134357	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21134357T>G	uc002ztb.1	+	2	824	c.757T>G	c.(757-759)TTC>GTC	p.F253V	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.F281V	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	253					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)													---	---	---	---
BCR	613	broad.mit.edu	37	22	23654017	23654017	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23654017G>A	uc002zww.2	+	19	3912	c.3316G>A	c.(3316-3318)GAC>AAC	p.D1106N	BCR_uc002zwx.2_Missense_Mutation_p.D1062N|BCR_uc011aiy.1_Missense_Mutation_p.D695N	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	1106	Rho-GAP.		D -> N.		regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12								T	ABL1| FGFR1|JAK2 	CML|ALL|AML								---	---	---	---
SLC2A11	66035	broad.mit.edu	37	22	24226131	24226131	+	Intron	SNP	G	A	A	rs145159477	by1000genomes	TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24226131G>A	uc002zyn.3	+						SLC2A11_uc002zyl.1_3'UTR|SLC2A11_uc002zym.3_Intron|SLC2A11_uc002zyo.3_Intron|SLC2A11_uc011ajc.1_Missense_Mutation_p.R359Q|SLC2A11_uc002zyp.3_Intron	NM_001024938	NP_001020109			glucose transporter protein 10 isoform c							integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1																		---	---	---	---
GAL3ST1	9514	broad.mit.edu	37	22	30951162	30951162	+	Silent	SNP	G	A	A	rs146972531		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30951162G>A	uc003aig.1	-	4	1190	c.1050C>T	c.(1048-1050)CAC>CAT	p.H350H	GAL3ST1_uc003aih.1_Silent_p.H350H|GAL3ST1_uc003aii.1_Silent_p.H350H|GAL3ST1_uc010gvz.1_Silent_p.H350H	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	350	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0																		---	---	---	---
EIF4ENIF1	56478	broad.mit.edu	37	22	31859740	31859740	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31859740C>T	uc003akz.1	-	5	676	c.512G>A	c.(511-513)CGT>CAT	p.R171H	EIF4ENIF1_uc003ala.1_Missense_Mutation_p.R171H|EIF4ENIF1_uc003alb.1_Intron	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	171	Arg-rich.					nucleus	protein binding|protein transporter activity			ovary(1)	1																		---	---	---	---
HMOX1	3162	broad.mit.edu	37	22	35783051	35783051	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:35783051C>T	uc003ant.1	+	3	598	c.518C>T	c.(517-519)GCC>GTC	p.A173V		NM_002133	NP_002124	P09601	HMOX1_HUMAN	heme oxygenase (decyclizing) 1	173					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			ovary(1)	1					NADH(DB00157)													---	---	---	---
APOL2	23780	broad.mit.edu	37	22	36624266	36624266	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36624266C>T	uc003aoz.2	-	5	534	c.198G>A	c.(196-198)AAG>AAA	p.K66K	APOL2_uc011amm.1_Silent_p.K178K|APOL2_uc003apa.2_Silent_p.K66K	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2	66					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0																		---	---	---	---
MYH9	4627	broad.mit.edu	37	22	36682871	36682871	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36682871G>A	uc003apg.2	-	35	5185	c.4954C>T	c.(4954-4956)CGC>TGC	p.R1652C		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1652	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11								T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated		OREG0026519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CSF2RB	1439	broad.mit.edu	37	22	37325725	37325725	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37325725G>A	uc003aqa.3	+	6	811	c.594G>A	c.(592-594)GGG>GGA	p.G198G	CSF2RB_uc003aqc.3_Silent_p.G198G	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	198	Fibronectin type-III 1.|Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)													---	---	---	---
TRIOBP	11078	broad.mit.edu	37	22	38119801	38119801	+	Missense_Mutation	SNP	A	G	G	rs71317064		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38119801A>G	uc003atr.2	+	7	1509	c.1238A>G	c.(1237-1239)AAA>AGA	p.K413R	TRIOBP_uc003atu.2_Missense_Mutation_p.K241R|TRIOBP_uc003atq.1_Missense_Mutation_p.K413R|TRIOBP_uc003ats.1_Missense_Mutation_p.K241R	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	413					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)																	---	---	---	---
GCAT	23464	broad.mit.edu	37	22	38212245	38212245	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38212245C>T	uc003atz.2	+	8	1045	c.1025C>T	c.(1024-1026)TCG>TTG	p.S342L	GCAT_uc003aua.1_Missense_Mutation_p.S368L	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	342					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)													---	---	---	---
TAB1	10454	broad.mit.edu	37	22	39826095	39826095	+	Silent	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39826095C>A	uc003axt.2	+	11	1432	c.1383C>A	c.(1381-1383)CTC>CTA	p.L461L	TAB1_uc003axr.2_Silent_p.L537L|TAB1_uc011aok.1_Silent_p.L295L|TAB1_uc003axu.1_Intron	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	461					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1																		---	---	---	---
SGSM3	27352	broad.mit.edu	37	22	40802507	40802507	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40802507G>A	uc003ayu.1	+	10	1235	c.1026G>A	c.(1024-1026)TCG>TCA	p.S342S	SGSM3_uc010gyc.1_3'UTR|SGSM3_uc011aos.1_Silent_p.S275S|SGSM3_uc011aot.1_Silent_p.S279S|SGSM3_uc010gyd.1_Silent_p.S342S	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	342					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2																		---	---	---	---
DNAJB7	150353	broad.mit.edu	37	22	41257517	41257517	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41257517C>T	uc003azj.2	-	1	614	c.482G>A	c.(481-483)GGT>GAT	p.G161D	XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azh.2_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_5'Flank|XPNPEP3_uc003azg.1_Intron|XPNPEP3_uc003azf.1_Intron|XPNPEP3_uc010gyh.1_5'Flank	NM_145174	NP_660157	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	161					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)	1																		---	---	---	---
EFCAB6	64800	broad.mit.edu	37	22	43926824	43926824	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43926824C>T	uc003bdy.1	-	31	4469	c.4254G>A	c.(4252-4254)ACG>ACA	p.T1418T	EFCAB6_uc003bdz.1_Silent_p.T1266T|EFCAB6_uc010gzi.1_Silent_p.T1266T	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1418	Interaction with AR.|Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)																---	---	---	---
NUP50	10762	broad.mit.edu	37	22	45571922	45571922	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45571922G>A	uc003bfr.2	+	4	763	c.301G>A	c.(301-303)GCC>ACC	p.A101T	NUP50_uc003bfs.2_Missense_Mutation_p.A73T|NUP50_uc011aqn.1_Intron|NUP50_uc003bft.2_Missense_Mutation_p.A73T|NUP50_uc011aqo.1_5'Flank	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	101	5 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)														---	---	---	---
FBLN1	2192	broad.mit.edu	37	22	45996204	45996204	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45996204C>T	uc003bgj.1	+	17	2137	c.1990C>T	c.(1990-1992)CGG>TGG	p.R664W	FBLN1_uc003bgk.1_RNA	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	664					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)														---	---	---	---
PKDREJ	10343	broad.mit.edu	37	22	46655212	46655212	+	Silent	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46655212A>G	uc003bhh.2	-	1	4008	c.4008T>C	c.(4006-4008)GAT>GAC	p.D1336D		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1336	Cytoplasmic (Potential).|PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)														---	---	---	---
TBC1D22A	25771	broad.mit.edu	37	22	47193446	47193446	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:47193446C>T	uc003bib.2	+	4	701	c.566C>T	c.(565-567)GCG>GTG	p.A189V	TBC1D22A_uc010haf.2_Missense_Mutation_p.A159V|TBC1D22A_uc003bic.2_Intron|TBC1D22A_uc003bie.2_Intron|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.A142V	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	189						intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)												OREG0026659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZBED4	9889	broad.mit.edu	37	22	50279870	50279870	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50279870C>T	uc003bix.2	+	2	3030	c.2560C>T	c.(2560-2562)CGG>TGG	p.R854W		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	854						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
MLC1	23209	broad.mit.edu	37	22	50523291	50523291	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50523291C>T	uc003bjg.1	-	2	314	c.41G>A	c.(40-42)CGG>CAG	p.R14Q	MLC1_uc011arl.1_Missense_Mutation_p.R14Q|MLC1_uc003bjh.1_Missense_Mutation_p.R14Q|MLC1_uc011arm.1_Missense_Mutation_p.R14Q|MLC1_uc011arn.1_Intron|MLC1_uc011aro.1_Missense_Mutation_p.R14Q	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	14						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)														---	---	---	---
MOV10L1	54456	broad.mit.edu	37	22	50591566	50591566	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50591566G>A	uc003bjj.2	+	22	3068	c.2985G>A	c.(2983-2985)GCG>GCA	p.A995A	MOV10L1_uc003bjk.3_Silent_p.A995A|MOV10L1_uc011arp.1_Silent_p.A975A|MOV10L1_uc003bjl.2_Silent_p.A122A|MOV10L1_uc003bjm.1_Silent_p.A38A	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	995					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)														---	---	---	---
TUBGCP6	85378	broad.mit.edu	37	22	50656171	50656171	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50656171G>A	uc003bkb.1	-	25	5966	c.5454C>T	c.(5452-5454)GAC>GAT	p.D1818D	TUBGCP6_uc003bka.1_Silent_p.D888D|TUBGCP6_uc010har.1_Silent_p.D1810D|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1818					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)														---	---	---	---
PLCXD1	55344	broad.mit.edu	37	X	200930	200930	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:200930G>A	uc004cpc.2	+	2	388	c.76G>A	c.(76-78)GCA>ACA	p.A26T	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	26					intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
KAL1	3730	broad.mit.edu	37	X	8504917	8504917	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:8504917G>A	uc004csf.2	-	11	1666	c.1516C>T	c.(1516-1518)CGG>TGG	p.R506W		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	506	Fibronectin type-III 3.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4																		---	---	---	---
WWC3	55841	broad.mit.edu	37	X	10046875	10046875	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10046875C>A	uc004csx.3	+	4	455	c.257C>A	c.(256-258)CCA>CAA	p.P86Q	WWC3_uc010nds.2_5'UTR|WWC3_uc010ndt.2_5'Flank	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	86	Potential.									ovary(4)	4																		---	---	---	---
ARHGAP6	395	broad.mit.edu	37	X	11682500	11682500	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11682500C>T	uc004cup.1	-	1	1322	c.449G>A	c.(448-450)CGA>CAA	p.R150Q	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.R150Q	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	150					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2																		---	---	---	---
ASB9	140462	broad.mit.edu	37	X	15287932	15287932	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15287932A>C	uc004cwl.2	-	1	312	c.65T>G	c.(64-66)ATC>AGC	p.I22S	ASB9_uc004cwk.2_Missense_Mutation_p.I22S|ASB9_uc004cwm.2_Missense_Mutation_p.I22S|ASB9_uc010ner.2_Missense_Mutation_p.I22S|ASB9_uc004cwn.2_Missense_Mutation_p.I22S	NM_001031739	NP_001026909	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box-containing 9 isoform	22					intracellular signal transduction						0	Hepatocellular(33;0.183)																	---	---	---	---
SYAP1	94056	broad.mit.edu	37	X	16773179	16773179	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16773179G>A	uc004cxp.2	+	6	780	c.687G>A	c.(685-687)GAG>GAA	p.E229E	SYAP1_uc004cxo.2_Silent_p.E229E|SYAP1_uc011miv.1_Silent_p.E195E	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	229										skin(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
SCML2	10389	broad.mit.edu	37	X	18278348	18278348	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18278348G>A	uc004cyl.2	-	9	1169	c.1012C>T	c.(1012-1014)CGT>TGT	p.R338C	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.R338C|SCML2_uc011miz.1_Missense_Mutation_p.R272C|SCML2_uc010nfc.2_Missense_Mutation_p.R74C	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	338					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
PPEF1	5475	broad.mit.edu	37	X	18836177	18836177	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18836177G>A	uc004cyq.2	+	16	1896	c.1415G>A	c.(1414-1416)AGC>AAC	p.S472N	PPEF1_uc004cyp.2_Missense_Mutation_p.S444N|PPEF1_uc004cyr.2_Missense_Mutation_p.S410N|PPEF1_uc004cys.2_Missense_Mutation_p.S472N|PPEF1_uc011mja.1_Missense_Mutation_p.S407N|PPEF1_uc011mjb.1_Missense_Mutation_p.S416N	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	472					detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)																	---	---	---	---
PHKA2	5256	broad.mit.edu	37	X	18949781	18949781	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18949781A>G	uc004cyv.3	-	12	1653	c.1223T>C	c.(1222-1224)ATC>ACC	p.I408T		NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	408					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)															OREG0019698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PHKA2	5256	broad.mit.edu	37	X	18969342	18969342	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18969342G>T	uc004cyv.3	-	4	764	c.334C>A	c.(334-336)CTG>ATG	p.L112M	PHKA2_uc010nfh.1_Intron|PHKA2_uc010nfi.1_Missense_Mutation_p.L54M	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	112					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
FAM47A	158724	broad.mit.edu	37	X	34148723	34148723	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:34148723G>A	uc004ddg.2	-	1	1706	c.1673C>T	c.(1672-1674)CCG>CTG	p.P558L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	558										ovary(4)|central_nervous_system(1)	5																		---	---	---	---
FAM47C	442444	broad.mit.edu	37	X	37026602	37026602	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:37026602T>C	uc004ddl.1	+	1	133	c.119T>C	c.(118-120)TTC>TCC	p.F40S		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	40										ovary(3)	3																		---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44918711	44918711	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44918711G>T	uc004dge.3	+	12	1569	c.1194G>T	c.(1192-1194)CAG>CAT	p.Q398H	KDM6A_uc010nhk.2_Missense_Mutation_p.Q398H|KDM6A_uc011mkz.1_Missense_Mutation_p.Q398H|KDM6A_uc011mla.1_Missense_Mutation_p.Q398H|KDM6A_uc011mlb.1_Missense_Mutation_p.Q398H|KDM6A_uc011mlc.1_Missense_Mutation_p.Q147H|KDM6A_uc011mld.1_Missense_Mutation_p.Q64H	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	398					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84								D|N|F|S		renal|oesophageal SCC|MM								---	---	---	---
KCND1	3750	broad.mit.edu	37	X	48826374	48826374	+	Missense_Mutation	SNP	C	T	T	rs147541534		TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48826374C>T	uc004dlx.1	-	1	1878	c.305G>A	c.(304-306)CGG>CAG	p.R102Q	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	102	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3																		---	---	---	---
MAGIX	79917	broad.mit.edu	37	X	49022484	49022484	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49022484T>A	uc010nin.1	+	6	798	c.751T>A	c.(751-753)TCC>ACC	p.S251T	MAGIX_uc010nio.1_Missense_Mutation_p.S175T|MAGIX_uc004dmt.2_Missense_Mutation_p.S170T|MAGIX_uc004dmu.2_Missense_Mutation_p.S192T|MAGIX_uc004dmw.2_Missense_Mutation_p.S179T	NM_024859	NP_079135	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked isoform a	251											0																		---	---	---	---
GSPT2	23708	broad.mit.edu	37	X	51488294	51488294	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:51488294T>C	uc004dpl.2	+	1	1798	c.1572T>C	c.(1570-1572)GTT>GTC	p.V524V		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	524					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)																	---	---	---	---
ZXDA	7789	broad.mit.edu	37	X	57935575	57935575	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:57935575C>T	uc004dve.2	-	1	1493	c.1280G>A	c.(1279-1281)TGC>TAC	p.C427Y		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	427	C2H2-type 6.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
SLC7A3	84889	broad.mit.edu	37	X	70148313	70148313	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70148313T>C	uc004dyn.2	-	4	858	c.700A>G	c.(700-702)ACC>GCC	p.T234A	SLC7A3_uc004dyo.2_Missense_Mutation_p.T234A	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	234	Helical; Name=6; (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)													---	---	---	---
SLC16A2	6567	broad.mit.edu	37	X	73641744	73641744	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73641744G>A	uc004ebt.2	+	1	660	c.494G>A	c.(493-495)GGC>GAC	p.G165D		NM_006517	NP_006508	P36021	MOT8_HUMAN	solute carrier family 16, member 2	91	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)													---	---	---	---
SATL1	340562	broad.mit.edu	37	X	84362935	84362935	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:84362935C>T	uc011mqx.1	-	1	1040	c.1040G>A	c.(1039-1041)AGC>AAC	p.S347N	SATL1_uc004een.2_Missense_Mutation_p.S347N	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	160	Gln-rich.						N-acetyltransferase activity			breast(2)	2																		---	---	---	---
CHM	1121	broad.mit.edu	37	X	85219036	85219036	+	Silent	SNP	G	A	A			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:85219036G>A	uc004eet.2	-	5	366	c.336C>T	c.(334-336)GTC>GTT	p.V112V	CHM_uc011mqz.1_5'UTR	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	112					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)																---	---	---	---
CSTF2	1478	broad.mit.edu	37	X	100079177	100079177	+	Silent	SNP	T	C	C			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100079177T>C	uc004egh.2	+	6	691	c.633T>C	c.(631-633)GCT>GCC	p.A211A	CSTF2_uc010nnd.2_Silent_p.A211A|CSTF2_uc004egi.2_Silent_p.A211A	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	211	Interactions with CSTF3 and SYMPK.|Gly/Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1																		---	---	---	---
TCEAL6	158931	broad.mit.edu	37	X	101396012	101396012	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:101396012C>T	uc004eiq.2	-	3	453	c.292G>A	c.(292-294)GAA>AAA	p.E98K		NM_001006938	NP_001006939	Q6IPX3	TCAL6_HUMAN	transcription elongation factor A (SII)-like 6	98					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1																		---	---	---	---
NGFRAP1	27018	broad.mit.edu	37	X	102632528	102632528	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102632528C>T	uc004eki.2	+	3	491	c.109C>T	c.(109-111)CGG>TGG	p.R37W	NGFRAP1_uc004ekh.2_Missense_Mutation_p.R27W|NGFRAP1_uc004ekj.1_Missense_Mutation_p.R37W	NM_206915	NP_996798	Q00994	BEX3_HUMAN	nerve growth factor receptor (TNFRSF16)	37					apoptosis|multicellular organismal development|nerve growth factor receptor signaling pathway	cytosol|nucleus	caspase regulator activity|metal ion binding				0																		---	---	---	---
FAM199X	139231	broad.mit.edu	37	X	103434328	103434328	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:103434328C>T	uc004elw.2	+	6	1202	c.1036C>T	c.(1036-1038)CGC>TGC	p.R346C	FAM199X_uc004elx.2_Missense_Mutation_p.R120C	NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	346										ovary(1)	1																		---	---	---	---
SLC6A14	11254	broad.mit.edu	37	X	115582794	115582794	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:115582794C>T	uc004eqi.2	+	8	1222	c.1118C>T	c.(1117-1119)GCC>GTC	p.A373V		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	373					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)													---	---	---	---
XPNPEP2	7512	broad.mit.edu	37	X	128879240	128879240	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:128879240C>T	uc004eut.1	+	4	540	c.296C>T	c.(295-297)GCA>GTA	p.A99V	XPNPEP2_uc011mum.1_Missense_Mutation_p.A99V	NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	99					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0																		---	---	---	---
UTP14A	10813	broad.mit.edu	37	X	129060265	129060265	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129060265C>T	uc004euz.2	+	14	2021	c.1993C>T	c.(1993-1995)CCA>TCA	p.P665S	UTP14A_uc011mup.1_Missense_Mutation_p.P613S|UTP14A_uc011muq.1_Missense_Mutation_p.P611S	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	665					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2																OREG0019920	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FHL1	2273	broad.mit.edu	37	X	135290661	135290661	+	Silent	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135290661C>T	uc004ezo.2	+	5	649	c.549C>T	c.(547-549)GCC>GCT	p.A183A	FHL1_uc010nrz.2_Silent_p.A183A|FHL1_uc004ezm.2_RNA|FHL1_uc004ezl.2_Silent_p.A183A|FHL1_uc004ezq.2_Intron|FHL1_uc011mvy.1_Silent_p.A183A|FHL1_uc011mvz.1_Silent_p.A183A|FHL1_uc004ezn.2_Silent_p.A183A|FHL1_uc011mwa.1_Silent_p.A212A|FHL1_uc011mwb.1_RNA|FHL1_uc004ezp.2_Silent_p.A199A|FHL1_uc004ezr.2_Missense_Mutation_p.P2L	NM_001159702	NP_001153174	Q13642	FHL1_HUMAN	four and a half LIM domains 1 isoform 1	183	LIM zinc-binding 3.				cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
VGLL1	51442	broad.mit.edu	37	X	135631137	135631137	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135631137C>T	uc004ezy.2	+	3	774	c.604C>T	c.(604-606)CTC>TTC	p.L202F	MIR934_hsa-mir-934|MI0005756_5'Flank	NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
F9	2158	broad.mit.edu	37	X	138630579	138630579	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138630579A>G	uc004fas.1	+	5	478	c.449A>G	c.(448-450)GAT>GGT	p.D150G	F9_uc004fat.1_Missense_Mutation_p.D112G	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	150	EGF-like 2.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)													---	---	---	---
MIR513C	100302114	broad.mit.edu	37	X	146271242	146271242	+	RNA	SNP	A	G	G			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:146271242A>G	hsa-mir-513c|MI0006649	-			c.64A>G																				0																		---	---	---	---
HCFC1	3054	broad.mit.edu	37	X	153220897	153220897	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4305-01	TCGA-CG-4305-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153220897G>T	uc004fjp.2	-	17	3481	c.2953C>A	c.(2953-2955)CCG>ACG	p.P985T		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	985					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
