Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
IL23R	149233	broad.mit.edu	37	1	67672589	67672589	+	Intron	DEL	C	-	-	rs111876012		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67672589delC	uc001ddo.2	+						IL23R_uc009waz.2_Intron|IL23R_uc001ddp.2_Intron|IL23R_uc010opi.1_Intron|IL23R_uc010opj.1_Intron|IL23R_uc010opk.1_Intron|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_Intron|IL23R_uc001ddq.2_Intron|IL23R_uc010opn.1_Intron|IL23R_uc001ddr.2_Intron|IL23R_uc010opo.1_Intron|IL23R_uc010opp.1_Intron|IL23R_uc010opq.1_Intron|IL23R_uc010opr.1_Intron|IL23R_uc010ops.1_Intron|IL23R_uc010opt.1_Intron|IL23R_uc010opu.1_Intron|IL23R_uc010opv.1_Intron|IL23R_uc010opw.1_Intron|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_Intron|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_Intron|IL23R_uc010oqb.1_Intron|IL23R_uc010oqc.1_Intron|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_Intron|IL23R_uc010oqf.1_Intron|IL23R_uc010oqg.1_Intron|IL23R_uc010oqh.1_Intron|IL23R_uc001dds.2_5'Flank|IL23R_uc001ddt.2_5'Flank	NM_144701	NP_653302			interleukin 23 receptor precursor						inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	112713516	112713519	+	IGR	DEL	AGGA	-	-	rs68114270		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:112713516_112713519delAGGA								KCND3 (181739 upstream) : CTTNBP2NL (225281 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	120112513	120112516	+	IGR	DEL	AAGA	-	-	rs75578437		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120112513_120112516delAAGA								HSD3B1 (54832 upstream) : ZNF697 (49484 downstream)																																			---	---	---	---
NBPF9	400818	broad.mit.edu	37	1	145109975	145109976	+	Intron	INS	-	C	C	rs11458983		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145109975_145109976insC	uc010oye.1	+						NBPF10_uc009wir.2_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|SEC22B_uc001eml.1_Intron					RecName: Full=Neuroblastoma breakpoint family member 8;							cytoplasm					0																		---	---	---	---
NBPF10	100132406	broad.mit.edu	37	1	145368208	145368213	+	Intron	DEL	TCTCTG	-	-	rs72354261		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145368208_145368213delTCTCTG	uc001end.3	+						NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792			hypothetical protein LOC100132406												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)														---	---	---	---
ASTN1	460	broad.mit.edu	37	1	176833843	176833844	+	Intron	INS	-	AATG	AATG			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176833843_176833844insAATG	uc001glc.2	-						ASTN1_uc001glb.1_Intron	NM_004319	NP_004310			astrotactin isoform 1						cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15																		---	---	---	---
NUP133	55746	broad.mit.edu	37	1	229631436	229631436	+	Intron	DEL	A	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229631436delA	uc001htn.2	-							NM_018230	NP_060700			nucleoporin 133kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)																---	---	---	---
Unknown	0	broad.mit.edu	37	1	240148045	240148048	+	IGR	DEL	AGGA	-	-	rs74342196		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240148045_240148048delAGGA								CHRM3 (75330 upstream) : FMN2 (107137 downstream)																																			---	---	---	---
CRIM1	51232	broad.mit.edu	37	2	36776050	36776050	+	3'UTR	DEL	T	-	-	rs11309348		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:36776050delT	uc002rpd.2	+	17						NM_016441	NP_057525			cysteine-rich motor neuron 1 precursor						nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)																---	---	---	---
Unknown	0	broad.mit.edu	37	2	129393430	129393437	+	IGR	DEL	CCTTCCTT	-	-	rs72091728		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:129393430_129393437delCCTTCCTT								HS6ST1 (317259 upstream) : None (None downstream)																																			---	---	---	---
KCNH7	90134	broad.mit.edu	37	2	163605441	163605442	+	Intron	INS	-	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163605441_163605442insT	uc002uch.1	-						KCNH7_uc002uci.2_Intron	NM_033272	NP_150375			potassium voltage-gated channel, subfamily H,						regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)													---	---	---	---
Unknown	0	broad.mit.edu	37	2	234699319	234699319	+	IGR	DEL	T	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234699319delT								UGT1A10 (17370 upstream) : HJURP (46168 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	3	128315979	128315994	+	IGR	DEL	GAAGGAAGGAAGGAAA	-	-	rs71720183		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128315979_128315994delGAAGGAAGGAAGGAAA								C3orf27 (21050 upstream) : RPN1 (22819 downstream)																																			---	---	---	---
ZBBX	79740	broad.mit.edu	37	3	167066050	167066057	+	Intron	DEL	GGAAGGAA	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167066050_167066057delGGAAGGAA	uc003fep.2	-						ZBBX_uc011bpc.1_Intron|ZBBX_uc003feq.2_Intron	NM_024687	NP_078963			zinc finger, B-box domain containing							intracellular	zinc ion binding			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	3578072	3578074	+	5'Flank	DEL	GAA	-	-	rs111370021		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3578072_3578074delGAA	uc003ghj.1	+						uc003ghk.1_5'Flank					Homo sapiens cDNA FLJ35424 fis, clone SMINT2001461.																														---	---	---	---
PRKG2	5593	broad.mit.edu	37	4	82031905	82031906	+	Intron	DEL	AG	-	-	rs113181803		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82031905_82031906delAG	uc003hmh.2	-						PRKG2_uc011ccf.1_Intron|PRKG2_uc011ccg.1_Intron|PRKG2_uc011cch.1_Intron	NM_006259	NP_006250			protein kinase, cGMP-dependent, type II						platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	138369697	138369697	+	IGR	DEL	A	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:138369697delA								None (None upstream) : PCDH18 (70379 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	5	2744188	2744191	+	IGR	DEL	GTGT	-	-	rs141265523		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:2744188_2744191delGTGT								IRX4 (861308 upstream) : IRX2 (2090 downstream)																																			---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	32000586	32000597	+	Intron	DEL	TTTGTTTTTGTT	-	-	rs71863988		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32000586_32000597delTTTGTTTTTGTT	uc003jhl.2	+						PDZD2_uc003jhm.2_Intron|PDZD2_uc011cnx.1_Intron	NM_178140	NP_835260			PDZ domain containing 2						cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
NUP155	9631	broad.mit.edu	37	5	37292320	37292320	+	Intron	DEL	T	-	-	rs34382591		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37292320delT	uc003jku.1	-						NUP155_uc003jkt.1_Intron|NUP155_uc010iuz.1_Intron	NM_153485	NP_705618			nucleoporin 155kDa isoform 1						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
Unknown	0	broad.mit.edu	37	5	128147553	128147556	+	IGR	DEL	CTTT	-	-	rs10040342		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:128147553_128147556delCTTT								FBN2 (273637 upstream) : SLC27A6 (153654 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	6	6811921	6811923	+	IGR	DEL	GAG	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:6811921_6811923delGAG								LY86 (156705 upstream) : RREB1 (296265 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	6	12628850	12628865	+	IGR	DEL	CCTCCCTCCCTCCCTT	-	-	rs146594740		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:12628850_12628865delCCTCCCTCCCTCCCTT								EDN1 (331424 upstream) : PHACTR1 (88023 downstream)																																			---	---	---	---
PMS2	5395	broad.mit.edu	37	7	6031805	6031805	+	Intron	DEL	T	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6031805delT	uc003spl.2	-						PMS2_uc003spj.2_Intron|PMS2_uc003spk.2_Intron|PMS2_uc011jwl.1_Intron|PMS2_uc010ktg.2_Intron|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Intron	NM_000535	NP_000526			PMS2 postmeiotic segregation increased 2 isoform						mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)				Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	7	25417784	25417791	+	IGR	DEL	CCCTTCCC	-	-	rs75017634		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:25417784_25417791delCCCTTCCC								NPVF (149679 upstream) : MIR148A (571748 downstream)																																			---	---	---	---
HNF4G	3174	broad.mit.edu	37	8	76378872	76378881	+	Intron	DEL	TCCCTTCCCT	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:76378872_76378881delTCCCTTCCCT	uc003yaq.2	+						HNF4G_uc003yap.1_Intron	NM_004133	NP_004124			hepatocyte nuclear factor 4, gamma						endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	95721448	95721448	+	IGR	DEL	G	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95721448delG								ESRP1 (1756 upstream) : DPY19L4 (10655 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	117311135	117311136	+	IGR	INS	-	AGAGAGAG	AGAGAGAG	rs145450413	by1000genomes	TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117311135_117311136insAGAGAGAG								DFNB31 (43405 upstream) : ATP6V1G1 (38858 downstream)																																			---	---	---	---
QSOX2	169714	broad.mit.edu	37	9	139107235	139107235	+	Intron	DEL	G	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139107235delG	uc010nbi.2	-							NM_181701	NP_859052			quiescin Q6 sulfhydryl oxidase 2 precursor						cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	81788176	81788176	+	IGR	DEL	A	-	-	rs35380147		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:81788176delA								MBL1P (77393 upstream) : LOC219347 (17815 downstream)																																			---	---	---	---
DRD4	1815	broad.mit.edu	37	11	640342	640342	+	Intron	DEL	G	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:640342delG	uc001lqp.1	+							NM_000797	NP_000788			dopamine receptor D4						activation of MAPK activity|adult locomotory behavior|arachidonic acid secretion|behavioral fear response|behavioral response to cocaine|behavioral response to ethanol|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of protein secretion|positive regulation of sodium:hydrogen antiporter activity|regulation of dopamine metabolic process|regulation of inhibitory postsynaptic membrane potential|response to amphetamine|response to histamine|social behavior	integral to plasma membrane	dopamine D4 receptor activity|drug binding|potassium channel regulator activity|SH3 domain binding				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.36e-28)|Epithelial(43;2.59e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Apomorphine(DB00714)|Clozapine(DB00363)|Olanzapine(DB00334)|Pramipexole(DB00413)|Promazine(DB00420)|Propiomazine(DB00777)|Ropinirole(DB00268)|Thiethylperazine(DB00372)|Ziprasidone(DB00246)													---	---	---	---
Unknown	0	broad.mit.edu	37	11	42010455	42010462	+	IGR	DEL	AAAAGAAA	-	-	rs72331687		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:42010455_42010462delAAAAGAAA								LRRC4C (529132 upstream) : None (None downstream)																																			---	---	---	---
CACNA1C	775	broad.mit.edu	37	12	2656822	2656823	+	Intron	DEL	TG	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2656822_2656823delTG	uc009zdu.1	+						CACNA1C_uc009zdv.1_Intron|CACNA1C_uc001qkb.2_Intron|CACNA1C_uc001qkc.2_Intron|CACNA1C_uc001qke.2_Intron|CACNA1C_uc001qkf.2_Intron|CACNA1C_uc001qjz.2_Intron|CACNA1C_uc001qkd.2_Intron|CACNA1C_uc001qkg.2_Intron|CACNA1C_uc009zdw.1_Intron|CACNA1C_uc001qkh.2_Intron|CACNA1C_uc001qkl.2_Intron|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Intron|CACNA1C_uc001qkp.2_Intron|CACNA1C_uc001qkr.2_Intron|CACNA1C_uc001qku.2_Intron|CACNA1C_uc001qkq.2_Intron|CACNA1C_uc001qks.2_Intron|CACNA1C_uc001qkt.2_Intron|CACNA1C_uc001qka.1_Intron|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Intron|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron|CACNA1C_uc009zdy.1_Intron|CACNA1C_uc001qkv.1_Intron	NM_199460	NP_955630			calcium channel, voltage-dependent, L type,						axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)													---	---	---	---
GPRC5D	55507	broad.mit.edu	37	12	13097780	13097781	+	Intron	INS	-	T	T	rs138260461	by1000genomes	TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:13097780_13097781insT	uc010shp.1	-							NM_018654	NP_061124			G protein-coupled receptor, family C, group 5,							integral to membrane|plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)														---	---	---	---
LMBR1L	55716	broad.mit.edu	37	12	49494515	49494516	+	Intron	INS	-	T	T	rs112884400		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49494515_49494516insT	uc001rth.3	-						LMBR1L_uc001rtg.3_Intron|LMBR1L_uc001rti.3_Intron	NM_018113	NP_060583			lipocalin-interacting membrane receptor						endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1																		---	---	---	---
TBC1D15	64786	broad.mit.edu	37	12	72286901	72286901	+	Intron	DEL	T	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72286901delT	uc001swu.2	+						TBC1D15_uc009zrv.2_Intron|TBC1D15_uc010stt.1_Intron|TBC1D15_uc001swv.2_Intron|TBC1D15_uc001sww.2_Intron	NM_022771	NP_073608			TBC1 domain family, member 15 isoform 1								protein binding|Rab GTPase activator activity				0																		---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79694127	79694130	+	Intron	DEL	TCCC	-	-	rs141857130	by1000genomes	TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79694127_79694130delTCCC	uc001xun.2	+						NRXN3_uc001xum.1_Intron	NM_004796	NP_004787			neurexin 3 isoform 1 precursor						axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
NF1P1	440225	broad.mit.edu	37	15	21135196	21135197	+	5'Flank	DEL	GT	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:21135196_21135197delGT	uc001ytv.1	-											Human NF1-related locus DNA in A9 mouse DNA background.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	31128275	31128275	+	IGR	DEL	T	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31128275delT								ARHGAP11B (150466 upstream) : MTMR15 (67780 downstream)																																			---	---	---	---
C16orf71	146562	broad.mit.edu	37	16	4788056	4788056	+	Intron	DEL	T	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4788056delT	uc002cxn.2	+							NM_139170	NP_631909			hypothetical protein LOC146562											central_nervous_system(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	33939019	33939019	+	IGR	DEL	C	-	-	rs113683091		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:33939019delC								None (None upstream) : MIR1826 (26489 downstream)																																			---	---	---	---
CES1	1066	broad.mit.edu	37	16	55869589	55869590	+	5'Flank	INS	-	AGGAAGGAAGGA	AGGAAGGAAGGA	rs9922024		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55869589_55869590insAGGAAGGAAGGA	uc002eim.2	-						CES1_uc002eil.2_5'Flank|CES1_uc002ein.2_5'Flank	NM_001025194	NP_001020365			carboxylesterase 1 isoform b precursor						response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)													---	---	---	---
Unknown	0	broad.mit.edu	37	17	15737072	15737073	+	IGR	INS	-	TTTA	TTTA	rs71838018		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15737072_15737073insTTTA								MEIS3P1 (44055 upstream) : ADORA2B (111158 downstream)																																			---	---	---	---
NPEPPS	9520	broad.mit.edu	37	17	45696920	45696921	+	Intron	INS	-	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45696920_45696921insA	uc002ilr.3	+						NPEPPS_uc010wkt.1_Intron|NPEPPS_uc010wku.1_Intron|NPEPPS_uc010wkv.1_Intron|NPEPPS_uc002ils.1_3'UTR	NM_006310	NP_006301			aminopeptidase puromycin sensitive						proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0																		---	---	---	---
EFCAB3	146779	broad.mit.edu	37	17	60475386	60475387	+	Intron	INS	-	A	A	rs146811952		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60475386_60475387insA	uc002izu.1	+						EFCAB3_uc010wpc.1_Intron	NM_173503	NP_775774			EF-hand calcium binding domain 3 isoform b								calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)															---	---	---	---
RGL3	57139	broad.mit.edu	37	19	11527833	11527833	+	Intron	DEL	T	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11527833delT	uc002mrp.2	-						RGL3_uc002mrn.2_Intron|RGL3_uc002mrm.2_Intron|RGL3_uc002mro.2_Intron|RGL3_uc002mrq.2_Intron	NM_001035223	NP_001030300			ral guanine nucleotide dissociation						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1																		---	---	---	---
TNPO2	30000	broad.mit.edu	37	19	12821703	12821704	+	Intron	INS	-	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12821703_12821704insT	uc002muo.2	-						TNPO2_uc002mup.2_Intron|TNPO2_uc002muq.2_Intron|TNPO2_uc002mur.2_Intron	NM_001136196	NP_001129668			transportin 2 (importin 3, karyopherin beta 2b)						intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	32420933	32420936	+	IGR	DEL	ACAC	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:32420933_32420936delACAC								TSHZ3 (580743 upstream) : ZNF507 (415578 downstream)																																			---	---	---	---
ZNF790	388536	broad.mit.edu	37	19	37309182	37309184	+	3'UTR	DEL	CTG	-	-	rs142103405		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37309182_37309184delCTG	uc002oew.2	-	5					uc002oev.1_Intron	NM_206894	NP_996777			zinc finger protein 790						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)															---	---	---	---
Unknown	0	broad.mit.edu	37	19	54810549	54810550	+	IGR	INS	-	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54810549_54810550insC								LILRA6 (6311 upstream) : LILRA5 (7804 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	20	19831683	19831698	+	IGR	DEL	AAGGAAGGAAGGAGAA	-	-	rs11475764		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:19831683_19831698delAAGGAAGGAAGGAGAA								SLC24A3 (128143 upstream) : RIN2 (38512 downstream)																																			---	---	---	---
ACSS2	55902	broad.mit.edu	37	20	33470426	33470426	+	Intron	DEL	A	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33470426delA	uc002xbd.2	+						ACSS2_uc002xbc.2_Intron|ACSS2_uc010zum.1_Intron|ACSS2_uc010gey.2_Intron|ACSS2_uc002xbe.2_Intron|ACSS2_uc002xbf.2_Intron	NM_018677	NP_061147			acyl-CoA synthetase short-chain family member 2						ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)													---	---	---	---
C21orf81	391267	broad.mit.edu	37	21	15347257	15347258	+	Intron	INS	-	A	A	rs80199214		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:15347257_15347258insA	uc002yji.2	-							NR_027270				Homo sapiens C21orf81 protein (C21orf81) mRNA, complete cds.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	21	44755913	44755914	+	IGR	INS	-	CAC	CAC	rs150119883	by1000genomes	TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44755913_44755914insCAC								CRYAA (163000 upstream) : SIK1 (78484 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	22	21579167	21579168	+	IGR	DEL	AT	-	-	rs415287		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21579167_21579168delAT								LOC400891 (160712 upstream) : POM121L8P (57546 downstream)																																			---	---	---	---
ASMT	438	broad.mit.edu	37	X	1749037	1749038	+	Intron	INS	-	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1749037_1749038insT	uc004cqd.2	+						ASMT_uc010ncy.2_Intron|ASMT_uc004cqe.2_Intron	NM_004043	NP_004034			acetylserotonin O-methyltransferase						melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
SAT1	6303	broad.mit.edu	37	X	23802147	23802147	+	Intron	DEL	A	-	-			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23802147delA	uc004dau.2	+						SAT1_uc010nfv.2_Frame_Shift_Del_p.K117fs|SAT1_uc004dav.2_Intron	NM_002970	NP_002961			diamine N-acetyltransferase 1						angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)													---	---	---	---
TAS1R3	83756	broad.mit.edu	37	1	1267882	1267882	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1267882T>C	uc010nyk.1	+	3	971	c.971T>C	c.(970-972)TTC>TCC	p.F324S		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	324	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)													---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19446105	19446105	+	Silent	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19446105C>T	uc001bbi.2	-	70	10405	c.10401G>A	c.(10399-10401)CAG>CAA	p.Q3467Q	UBR4_uc001bbj.1_5'Flank	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3467					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)														---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19523680	19523680	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19523680G>A	uc001bbi.2	-	8	977	c.973C>T	c.(973-975)CGT>TGT	p.R325C		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	325					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)														---	---	---	---
CELA3B	23436	broad.mit.edu	37	1	22313186	22313186	+	Intron	SNP	G	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22313186G>C	uc001bfk.2	+						CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378			elastase 3B, pancreatic preproprotein						cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
CELA3A	10136	broad.mit.edu	37	1	22336360	22336360	+	Intron	SNP	G	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22336360G>C	uc001bfl.2	+							NM_005747	NP_005738			elastase 3A, pancreatic preproprotein						cholesterol metabolic process|digestion|proteolysis		serine-type endopeptidase activity			haematopoietic_and_lymphoid_tissue(1)	1																		---	---	---	---
PEAR1	375033	broad.mit.edu	37	1	156883511	156883511	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156883511G>A	uc001fqj.1	+	21	2788	c.2672G>A	c.(2671-2673)AGC>AAC	p.S891N	PEAR1_uc001fqk.1_Missense_Mutation_p.S516N	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	891	Pro-rich.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)																	---	---	---	---
CD1C	911	broad.mit.edu	37	1	158261152	158261152	+	Missense_Mutation	SNP	G	T	T	rs114534381	byFrequency;by1000genomes	TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158261152G>T	uc001fru.2	+	2	582	c.290G>T	c.(289-291)CGG>CTG	p.R97L	CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	97	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)																	---	---	---	---
TNFSF4	7292	broad.mit.edu	37	1	173155745	173155745	+	Silent	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173155745G>T	uc001giw.2	-	3	618	c.462C>A	c.(460-462)ACC>ACA	p.T154T	TNFSF4_uc001giv.2_Silent_p.T104T	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	154	Extracellular (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1																		---	---	---	---
ASTN1	460	broad.mit.edu	37	1	177001708	177001708	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:177001708C>T	uc001glc.2	-	3	961	c.749G>A	c.(748-750)CGC>CAC	p.R250H	ASTN1_uc001glb.1_Missense_Mutation_p.R250H|ASTN1_uc001gld.1_Missense_Mutation_p.R250H|ASTN1_uc009wwx.1_Missense_Mutation_p.R250H|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	250					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186099238	186099238	+	Intron	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186099238G>T	uc001grq.1	+						HMCN1_uc001grs.1_Intron	NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
SUSD4	55061	broad.mit.edu	37	1	223441918	223441918	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223441918C>A	uc001hnx.2	-	3	1095	c.461G>T	c.(460-462)CGG>CTG	p.R154L	SUSD4_uc001hny.3_Missense_Mutation_p.R154L|SUSD4_uc010puw.1_5'UTR|SUSD4_uc001hnz.2_Missense_Mutation_p.R154L|SUSD4_uc010pux.1_Missense_Mutation_p.R83L	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	154	Sushi 2.|Extracellular (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)														---	---	---	---
IL1RL2	8808	broad.mit.edu	37	2	102851397	102851397	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102851397G>T	uc002tbs.2	+	11	1464	c.1338G>T	c.(1336-1338)AGG>AGT	p.R446S	IL1RL2_uc002tbt.2_Missense_Mutation_p.R328S	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	446	TIR.|Cytoplasmic (Potential).				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2																		---	---	---	---
DPP10	57628	broad.mit.edu	37	2	116572421	116572421	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:116572421G>T	uc002tla.1	+	20	2210	c.1753G>T	c.(1753-1755)GAT>TAT	p.D585Y	DPP10_uc002tlb.1_Missense_Mutation_p.D535Y|DPP10_uc002tlc.1_Missense_Mutation_p.D581Y|DPP10_uc002tle.2_Missense_Mutation_p.D589Y|DPP10_uc002tlf.1_Missense_Mutation_p.D578Y	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	585	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10																		---	---	---	---
ZAK	51776	broad.mit.edu	37	2	174074513	174074513	+	Silent	SNP	G	A	A	rs145549000		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:174074513G>A	uc002uhz.2	+	10	1001	c.801G>A	c.(799-801)ACG>ACA	p.T267T	ZAK_uc002uhx.2_Silent_p.T267T|ZAK_uc002uhy.2_Silent_p.T267T|ZAK_uc010zei.1_Silent_p.T166T|ZAK_uc002uia.1_Silent_p.T267T|uc002uib.2_RNA	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	267	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179424507	179424507	+	Silent	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179424507G>T	uc010zfg.1	-	275	78872	c.78648C>A	c.(78646-78648)CCC>CCA	p.P26216P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.P19911P|TTN_uc010zfi.1_Silent_p.P19844P|TTN_uc010zfj.1_Silent_p.P19719P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27143							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
BARD1	580	broad.mit.edu	37	2	215646142	215646142	+	Silent	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215646142C>T	uc002veu.2	-	4	591	c.456G>A	c.(454-456)AAG>AAA	p.K152K	BARD1_uc010zjm.1_Silent_p.K8K	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	152					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)										Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				---	---	---	---
TTLL4	9654	broad.mit.edu	37	2	219609922	219609922	+	Silent	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219609922C>T	uc002viy.2	+	6	2122	c.1752C>T	c.(1750-1752)CCC>CCT	p.P584P	TTLL4_uc010zkl.1_Silent_p.P419P|TTLL4_uc010fvx.2_Silent_p.P584P|TTLL4_uc010zkm.1_5'Flank	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	584					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)														---	---	---	---
RBMS3	27303	broad.mit.edu	37	3	29781274	29781274	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:29781274G>C	uc003cel.2	+	5	693	c.463G>C	c.(463-465)GAG>CAG	p.E155Q	RBMS3_uc003cek.2_Missense_Mutation_p.E155Q|RBMS3_uc010hfq.2_Missense_Mutation_p.E155Q|RBMS3_uc003cem.2_Missense_Mutation_p.E154Q|RBMS3_uc010hfr.2_Missense_Mutation_p.E155Q	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	155	RRM 2.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)																---	---	---	---
ZBTB11	27107	broad.mit.edu	37	3	101384055	101384055	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101384055T>A	uc003dve.3	-	4	1606	c.1376A>T	c.(1375-1377)GAT>GTT	p.D459V		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1																		---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133327374	133327374	+	Intron	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133327374C>T	uc003eps.2	-							NM_007027	NP_008958			topoisomerase (DNA) II binding protein 1						DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
DEFB131	644414	broad.mit.edu	37	4	9452104	9452104	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:9452104A>G	uc011bwt.1	+	2	77	c.77A>G	c.(76-78)AAT>AGT	p.N26S		NM_001040448	NP_001035538	P59861	DB131_HUMAN	defensin, beta 131 precursor	26					defense response to bacterium	extracellular region					0																		---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89981640	89981640	+	Silent	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89981640G>A	uc003kju.2	+	29	6414	c.6318G>A	c.(6316-6318)GCG>GCA	p.A2106A	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2106	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.A2106V(1)		ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
PHACTR1	221692	broad.mit.edu	37	6	12933931	12933931	+	Intron	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:12933931C>A	uc010jpc.2	+						PHACTR1_uc011dir.1_Intron|PHACTR1_uc003nag.1_Intron|PHACTR1_uc003nah.1_Intron|PHACTR1_uc003nai.2_Missense_Mutation_p.P106H	NM_030948	NP_112210			phosphatase and actin regulator 1							cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)															---	---	---	---
JARID2	3720	broad.mit.edu	37	6	15512493	15512493	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:15512493C>A	uc003nbj.2	+	14	3251	c.3007C>A	c.(3007-3009)CAG>AAG	p.Q1003K	JARID2_uc011div.1_Missense_Mutation_p.Q831K	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	1003	JmjC.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)																---	---	---	---
VARS2	57176	broad.mit.edu	37	6	30890739	30890739	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30890739C>T	uc003nsc.1	+	22	2803	c.2171C>T	c.(2170-2172)TCC>TTC	p.S724F	VARS2_uc011dmx.1_Missense_Mutation_p.S724F|VARS2_uc011dmy.1_Missense_Mutation_p.S584F|VARS2_uc011dmz.1_Missense_Mutation_p.S754F|VARS2_uc011dna.1_Missense_Mutation_p.S722F|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_Missense_Mutation_p.S162F|VARS2_uc010jsg.1_Missense_Mutation_p.S96F|VARS2_uc010jsh.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	724					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75843039	75843039	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75843039C>A	uc003phs.2	-	34	5930	c.5764G>T	c.(5764-5766)GGG>TGG	p.G1922W	COL12A1_uc003pht.2_Missense_Mutation_p.G758W	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1922	Fibronectin type-III 14.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
FYN	2534	broad.mit.edu	37	6	112029214	112029214	+	Silent	SNP	A	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112029214A>G	uc003pvj.2	-	5	694	c.354T>C	c.(352-354)GAT>GAC	p.D118D	FYN_uc003pvi.2_Silent_p.D118D|FYN_uc003pvk.2_Silent_p.D118D|FYN_uc003pvh.2_Silent_p.D118D	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	118	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)													---	---	---	---
DNAH11	8701	broad.mit.edu	37	7	21939016	21939016	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21939016C>T	uc003svc.2	+	81	13164	c.13133C>T	c.(13132-13134)CCG>CTG	p.P4378L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4378					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														Kartagener_syndrome				---	---	---	---
DDC	1644	broad.mit.edu	37	7	50607687	50607687	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:50607687G>A	uc003tpf.3	-	3	327	c.241C>T	c.(241-243)CCC>TCC	p.P81S	DDC_uc010kza.2_Missense_Mutation_p.P81S|DDC_uc003tpg.3_Missense_Mutation_p.P81S	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	81	1.|2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)													---	---	---	---
MAGI2	9863	broad.mit.edu	37	7	78256458	78256458	+	Silent	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:78256458G>A	uc003ugx.2	-	3	770	c.516C>T	c.(514-516)CTC>CTT	p.L172L	MAGI2_uc003ugy.2_Silent_p.L172L|MAGI2_uc011kgr.1_5'UTR|MAGI2_uc011kgs.1_Silent_p.L9L	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	172	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)																---	---	---	---
PCLO	27445	broad.mit.edu	37	7	82579972	82579972	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82579972T>G	uc003uhx.2	-	6	10221	c.9932A>C	c.(9931-9933)AAG>ACG	p.K3311T	PCLO_uc003uhv.2_Missense_Mutation_p.K3311T|PCLO_uc010lec.2_Missense_Mutation_p.K276T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3242	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7																		---	---	---	---
SLC25A40	55972	broad.mit.edu	37	7	87477182	87477182	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87477182C>G	uc003uje.2	-	7	794	c.443G>C	c.(442-444)GGA>GCA	p.G148A		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	148	Helical; Name=3; (Potential).|Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)																	---	---	---	---
C7orf63	79846	broad.mit.edu	37	7	89938590	89938590	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:89938590T>A	uc010lep.2	+	22	2815	c.2564T>A	c.(2563-2565)CTT>CAT	p.L855H	C7orf63_uc011khj.1_Missense_Mutation_p.L837H|C7orf63_uc011khk.1_Missense_Mutation_p.L371H	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	855							binding			ovary(1)	1																		---	---	---	---
ZKSCAN5	23660	broad.mit.edu	37	7	99117466	99117466	+	Silent	SNP	A	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99117466A>G	uc003uqv.2	+	4	694	c.570A>G	c.(568-570)CAA>CAG	p.Q190Q	ZKSCAN5_uc010lfx.2_Silent_p.Q190Q|ZKSCAN5_uc003uqw.2_Silent_p.Q190Q|ZKSCAN5_uc003uqx.2_Intron|ZKSCAN5_uc003uqy.2_5'UTR	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	190					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)																	---	---	---	---
TFR2	7036	broad.mit.edu	37	7	100230926	100230926	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100230926C>A	uc003uvv.1	-	5	693	c.652G>T	c.(652-654)GGG>TGG	p.G218W	TFR2_uc010lhc.1_5'Flank|TFR2_uc003uvu.1_Missense_Mutation_p.G47W	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	218	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)																	---	---	---	---
SRRT	51593	broad.mit.edu	37	7	100486083	100486083	+	Intron	SNP	C	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100486083C>G	uc003uwy.2	+						SRRT_uc010lhl.1_Intron|SRRT_uc003uxa.2_Intron|SRRT_uc003uwz.2_Intron|uc010lhm.1_5'Flank	NM_015908	NP_056992			arsenate resistance protein 2 isoform a						cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
SERPINE1	5054	broad.mit.edu	37	7	100773794	100773794	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100773794G>A	uc003uxt.2	+	3	512	c.364G>A	c.(364-366)GTC>ATC	p.V122I	SERPINE1_uc011kkj.1_Missense_Mutation_p.V107I|SERPINE1_uc003uxu.1_5'Flank	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	122					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)													---	---	---	---
PLEKHA2	59339	broad.mit.edu	37	8	38775593	38775593	+	Intron	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38775593G>T	uc003xmi.3	+						PLEKHA2_uc011lce.1_Intron	NM_021623	NP_067636			pleckstrin homology domain containing, family A						positive regulation of cell-matrix adhesion	cytoplasm|nucleus|plasma membrane|protein complex	fibronectin binding|laminin binding				0		all_lung(54;0.0413)|Lung NSC(58;0.115)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;4.68e-08)|COAD - Colon adenocarcinoma(9;0.235)															---	---	---	---
MTDH	92140	broad.mit.edu	37	8	98656725	98656725	+	5'UTR	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:98656725G>T	uc003yhz.2	+	1						NM_178812	NP_848927			metadherin						lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103301735	103301735	+	Silent	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103301735G>T	uc003ykr.1	-	35	4692	c.4659C>A	c.(4657-4659)CCC>CCA	p.P1553P	UBR5_uc003yks.1_Silent_p.P1553P	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1553					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
MTSS1	9788	broad.mit.edu	37	8	125603445	125603445	+	Silent	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125603445G>A	uc003yrk.2	-	4	774	c.240C>T	c.(238-240)ACC>ACT	p.T80T	MTSS1_uc003yrj.2_Silent_p.T80T|MTSS1_uc003yrl.2_Silent_p.T80T	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	80	IMD.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
NFKBIL2	4796	broad.mit.edu	37	8	145666337	145666337	+	Intron	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145666337G>T	uc011llg.1	-							NM_013432	NP_038460			NF-kappa-B inhibitor-like protein 2						cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)															---	---	---	---
KIF27	55582	broad.mit.edu	37	9	86504177	86504177	+	Intron	SNP	T	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86504177T>C	uc004ana.2	-						KIF27_uc010mpw.2_Intron|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046			kinesin family member 27						cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5																		---	---	---	---
C9orf79	286234	broad.mit.edu	37	9	90500005	90500005	+	Silent	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90500005C>T	uc004app.3	+	4	638	c.603C>T	c.(601-603)ACC>ACT	p.T201T	C9orf79_uc004apo.1_Intron	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	201	Pro-rich.					integral to membrane				ovary(3)	3																		---	---	---	---
SOHLH1	402381	broad.mit.edu	37	9	138588519	138588519	+	Silent	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138588519C>T	uc004cgl.2	-	5	661	c.600G>A	c.(598-600)ACG>ACA	p.T200T	SOHLH1_uc010nbe.2_Silent_p.T200T	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	200					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)														---	---	---	---
ITIH2	3698	broad.mit.edu	37	10	7763667	7763667	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7763667G>T	uc001ijs.2	+	8	956	c.794G>T	c.(793-795)CGG>CTG	p.R265L		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	265					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
ITGA8	8516	broad.mit.edu	37	10	15714730	15714730	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15714730C>T	uc001ioc.1	-	7	695	c.695G>A	c.(694-696)AGT>AAT	p.S232N	ITGA8_uc010qcb.1_Missense_Mutation_p.S232N	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	232	FG-GAP 3.|Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6																		---	---	---	---
PTER	9317	broad.mit.edu	37	10	16553208	16553208	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:16553208G>A	uc001iog.1	+	6	1210	c.1003G>A	c.(1003-1005)GAT>AAT	p.D335N	PTER_uc001ioh.1_Missense_Mutation_p.D335N|PTER_uc001ioi.1_Missense_Mutation_p.D335N|PTER_uc009xjp.1_Missense_Mutation_p.D288N	NM_030664	NP_109589	Q96BW5	PTER_HUMAN	phosphotriesterase related	335					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			ovary(2)	2																		---	---	---	---
CUBN	8029	broad.mit.edu	37	10	16941012	16941012	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:16941012G>A	uc001ioo.2	-	54	8633	c.8581C>T	c.(8581-8583)CAG>TAG	p.Q2861*	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Nonsense_Mutation_p.Q217*	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2861	CUB 21.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
ANKRD30A	91074	broad.mit.edu	37	10	37430948	37430948	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:37430948C>G	uc001iza.1	+	7	1054	c.955C>G	c.(955-957)CCA>GCA	p.P319A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	375						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9																		---	---	---	---
TRUB1	142940	broad.mit.edu	37	10	116698112	116698112	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116698112A>C	uc001lcd.2	+	1	161	c.100A>C	c.(100-102)ACC>CCC	p.T34P	TRUB1_uc010qsl.1_Intron	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	34					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)														---	---	---	---
MUC6	4588	broad.mit.edu	37	11	1016108	1016108	+	Silent	SNP	A	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1016108A>G	uc001lsw.2	-	31	6744	c.6693T>C	c.(6691-6693)GTT>GTC	p.V2231V		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2231	Ser-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
OR51B6	390058	broad.mit.edu	37	11	5373214	5373214	+	Silent	SNP	T	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5373214T>A	uc010qzb.1	+	1	477	c.477T>A	c.(475-477)GTT>GTA	p.V159V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
CHST1	8534	broad.mit.edu	37	11	45672136	45672136	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45672136C>A	uc001mys.1	-	4	1009	c.338G>T	c.(337-339)CGG>CTG	p.R113L		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	113	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)														---	---	---	---
MS4A10	341116	broad.mit.edu	37	11	60565933	60565933	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60565933C>A	uc001npz.1	+	7	764	c.668C>A	c.(667-669)CCG>CAG	p.P223Q		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	223	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
RCE1	9986	broad.mit.edu	37	11	66611449	66611449	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66611449T>C	uc001ojk.1	+	3	355	c.311T>C	c.(310-312)CTG>CCG	p.L104P	RCE1_uc001ojl.1_5'UTR	NM_005133	NP_005124	Q9Y256	FACE2_HUMAN	prenyl protein peptidase RCE1 isoform 1	104					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			ovary(1)|breast(1)	2																		---	---	---	---
PITPNM1	9600	broad.mit.edu	37	11	67260874	67260874	+	Intron	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67260874G>A	uc001olx.2	-						PITPNM1_uc001olw.2_Intron|PITPNM1_uc001oly.2_Intron|PITPNM1_uc001olz.2_Intron	NM_004910	NP_004901			phosphatidylinositol transfer protein,						brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3																		---	---	---	---
PPFIA1	8500	broad.mit.edu	37	11	70172808	70172808	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70172808C>T	uc001opo.2	+	7	1012	c.814C>T	c.(814-816)CGC>TGC	p.R272C	PPFIA1_uc001opn.1_Missense_Mutation_p.R272C|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	272	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)															---	---	---	---
NPAT	4863	broad.mit.edu	37	11	108043212	108043212	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108043212A>C	uc001pjz.3	-	13	2601	c.2499T>G	c.(2497-2499)ATT>ATG	p.I833M	NPAT_uc010rvv.1_5'Flank|NPAT_uc001pka.2_Missense_Mutation_p.I628M	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	833	Required for acceleration of G1 phase.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)														---	---	---	---
GAPDH	2597	broad.mit.edu	37	12	6644033	6644033	+	Intron	SNP	T	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6644033T>G	uc001qop.1	+						GAPDH_uc009zep.1_Splice_Site|GAPDH_uc001qoq.1_Intron|GAPDH_uc001qor.1_Intron|GAPDH_uc001qos.1_Intron|GAPDH_uc001qot.1_Intron|GAPDH_uc001qou.1_Intron|GAPDH_uc001qov.1_5'Flank|GAPDH_uc001qow.1_5'Flank|GAPDH_uc001qox.1_5'Flank	NM_002046	NP_002037			glyceraldehyde-3-phosphate dehydrogenase						gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding				0					NADH(DB00157)													---	---	---	---
PLBD1	79887	broad.mit.edu	37	12	14659923	14659923	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14659923C>T	uc001rcc.1	-	9	1477	c.1316G>A	c.(1315-1317)CGT>CAT	p.R439H		NM_024829	NP_079105	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	439					lipid catabolic process	extracellular region	hydrolase activity				0																		---	---	---	---
DDX11	1663	broad.mit.edu	37	12	31255198	31255198	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:31255198G>A	uc001rjt.1	+	22	2475	c.2224G>A	c.(2224-2226)GCA>ACA	p.A742T	DDX11_uc001rjr.1_Missense_Mutation_p.A742T|DDX11_uc001rjs.1_Missense_Mutation_p.A692T|DDX11_uc001rju.1_Missense_Mutation_p.A414T|DDX11_uc001rjv.1_Missense_Mutation_p.A742T|DDX11_uc001rjw.1_Missense_Mutation_p.A716T|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	742					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)														Multiple Myeloma(12;0.14)			---	---	---	---
SLC11A2	4891	broad.mit.edu	37	12	51390641	51390641	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51390641T>C	uc001rxe.3	-	9	887	c.790A>G	c.(790-792)ATC>GTC	p.I264V	SLC11A2_uc001rxd.3_Missense_Mutation_p.I113V|SLC11A2_uc001rxc.3_Missense_Mutation_p.I264V|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_5'Flank|SLC11A2_uc010smx.1_Missense_Mutation_p.I260V|SLC11A2_uc001rxh.1_Missense_Mutation_p.I264V|SLC11A2_uc001rxj.1_Missense_Mutation_p.I264V|SLC11A2_uc001rxi.2_Missense_Mutation_p.I264V|SLC11A2_uc001rxk.1_Missense_Mutation_p.I293V|SLC11A2_uc010smy.1_Missense_Mutation_p.I227V	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	264	Helical; (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1																		---	---	---	---
STARD13	90627	broad.mit.edu	37	13	33703986	33703986	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33703986C>A	uc001uuw.2	-	5	954	c.828G>T	c.(826-828)AAG>AAT	p.K276N	STARD13_uc001uuu.2_Missense_Mutation_p.K268N|STARD13_uc001uuv.2_Missense_Mutation_p.K158N|STARD13_uc001uux.2_Missense_Mutation_p.K241N|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.K261N	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	276					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)														---	---	---	---
STARD13	90627	broad.mit.edu	37	13	33704356	33704356	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33704356C>A	uc001uuw.2	-	5	584	c.458G>T	c.(457-459)TGG>TTG	p.W153L	STARD13_uc001uuu.2_Missense_Mutation_p.W145L|STARD13_uc001uuv.2_Missense_Mutation_p.W35L|STARD13_uc001uux.2_Missense_Mutation_p.W118L|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.W138L	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	153					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)														---	---	---	---
CCNA1	8900	broad.mit.edu	37	13	37016312	37016312	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37016312A>C	uc001uvr.3	+	8	1567	c.1217A>C	c.(1216-1218)GAA>GCA	p.E406A	CCNA1_uc010teo.1_Missense_Mutation_p.E362A|CCNA1_uc010abq.2_Missense_Mutation_p.E362A|CCNA1_uc010abp.2_Missense_Mutation_p.E362A|CCNA1_uc001uvs.3_Missense_Mutation_p.E405A|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	406					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)														---	---	---	---
TRIM13	10206	broad.mit.edu	37	13	50586534	50586534	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50586534G>A	uc001vdq.1	+	3	771	c.458G>A	c.(457-459)CGT>CAT	p.R153H	DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|KCNRG_uc001vdt.2_5'Flank|KCNRG_uc001vdu.2_5'Flank|TRIM13_uc001vdp.1_Missense_Mutation_p.R156H|TRIM13_uc001vdr.1_Missense_Mutation_p.R153H|TRIM13_uc001vds.1_Missense_Mutation_p.R153H	NM_052811	NP_434698	O60858	TRI13_HUMAN	ret finger protein 2 isoform 1	153					anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)														---	---	---	---
EDNRB	1910	broad.mit.edu	37	13	78492255	78492255	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:78492255C>T	uc001vko.2	-	1	712	c.454G>A	c.(454-456)GTC>ATC	p.V152I	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Missense_Mutation_p.V152I|EDNRB_uc010aez.1_Missense_Mutation_p.V152I|EDNRB_uc001vkp.1_Missense_Mutation_p.V235I|EDNRB_uc010afa.1_Missense_Mutation_p.V152I	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	152	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)													---	---	---	---
SYNE2	23224	broad.mit.edu	37	14	64619390	64619390	+	Silent	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64619390C>A	uc001xgm.2	+	85	15978	c.15748C>A	c.(15748-15750)CGA>AGA	p.R5250R	SYNE2_uc001xgl.2_Silent_p.R5250R|SYNE2_uc010apy.2_Silent_p.R1635R|SYNE2_uc001xgn.2_Silent_p.R212R|SYNE2_uc001xgo.2_RNA	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5250	Spectrin 3.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)														---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94173133	94173133	+	Silent	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94173133G>A	uc001ybv.1	+	48	7409	c.7326G>A	c.(7324-7326)TCG>TCA	p.S2442S	KIAA1409_uc001ybs.1_Silent_p.S2420S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2597						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
ASB2	51676	broad.mit.edu	37	14	94405616	94405616	+	Silent	SNP	G	A	A	rs140791740		TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94405616G>A	uc001ycc.1	-	6	1800	c.1311C>T	c.(1309-1311)GCC>GCT	p.A437A	ASB2_uc001ycb.1_Silent_p.A131A|ASB2_uc001ycd.2_Silent_p.A485A|ASB2_uc001yce.1_Silent_p.A383A	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	437	ANK 12.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)														---	---	---	---
AQR	9716	broad.mit.edu	37	15	35196621	35196621	+	Silent	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35196621G>A	uc001ziv.2	-	19	2098	c.1917C>T	c.(1915-1917)ACC>ACT	p.T639T		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	639						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)														---	---	---	---
MT1F	4494	broad.mit.edu	37	16	56691977	56691977	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56691977C>A	uc002ejt.2	+	1	123	c.7C>A	c.(7-9)CCC>ACC	p.P3T		NM_005949	NP_005940	P04733	MT1F_HUMAN	metallothionein 1F	3	Beta.					cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding				0																		---	---	---	---
UNC45B	146862	broad.mit.edu	37	17	33495164	33495164	+	Silent	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33495164G>A	uc002hja.2	+	10	1333	c.1236G>A	c.(1234-1236)CTG>CTA	p.L412L	UNC45B_uc002hjb.2_Silent_p.L412L|UNC45B_uc002hjc.2_Silent_p.L412L|UNC45B_uc010cto.2_Silent_p.L412L	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	412					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)																---	---	---	---
AOC2	314	broad.mit.edu	37	17	41001202	41001202	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41001202A>T	uc002ibu.2	+	2	1723	c.1688A>T	c.(1687-1689)CAG>CTG	p.Q563L	AOC2_uc002ibt.2_Missense_Mutation_p.Q563L|AOC3_uc002ibv.2_5'Flank	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	563					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)														---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65186373	65186373	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65186373A>G	uc010wqk.1	-	10	843	c.656T>C	c.(655-657)CTG>CCG	p.L219P	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.L219P	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
DNAI2	64446	broad.mit.edu	37	17	72295860	72295860	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72295860G>T	uc002jkf.2	+	7	827	c.728G>T	c.(727-729)TGC>TTC	p.C243F	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	243	WD 2.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3														Kartagener_syndrome				---	---	---	---
DUS1L	64118	broad.mit.edu	37	17	80019108	80019108	+	Silent	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80019108G>A	uc002kdq.2	-	7	1238	c.819C>T	c.(817-819)CAC>CAT	p.H273H	DUS1L_uc002kdp.2_Silent_p.H142H|DUS1L_uc002kdr.2_Silent_p.H273H|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA|DUS1L_uc010wvi.1_Silent_p.H256H	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	273					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)															---	---	---	---
CEP192	55125	broad.mit.edu	37	18	13067827	13067827	+	Intron	SNP	T	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:13067827T>G	uc010xac.1	+						CEP192_uc010dlf.1_Intron|CEP192_uc010xad.1_Intron|CEP192_uc002kru.2_Intron|CEP192_uc002krv.2_Intron|CEP192_uc002krw.2_5'Flank	NM_032142	NP_115518			centrosomal protein 192kDa											ovary(4)|pancreas(1)	5																		---	---	---	---
SYT4	6860	broad.mit.edu	37	18	40850588	40850588	+	Silent	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:40850588G>A	uc002law.2	-	4	1365	c.996C>T	c.(994-996)TAC>TAT	p.Y332Y	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Silent_p.Y314Y|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	332	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5																		---	---	---	---
ACTL9	284382	broad.mit.edu	37	19	8808873	8808873	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8808873G>A	uc002mkl.2	-	1	300	c.179C>T	c.(178-180)ACC>ATC	p.T60I		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	60						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3																		---	---	---	---
FCHO1	23149	broad.mit.edu	37	19	17883497	17883497	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17883497A>G	uc010ebb.2	+	10	926	c.737A>G	c.(736-738)GAG>GGG	p.E246G	FCHO1_uc002nhg.3_Missense_Mutation_p.E246G|FCHO1_uc002nhh.2_Missense_Mutation_p.E246G|FCHO1_uc010xpw.1_Missense_Mutation_p.E196G|FCHO1_uc010ebc.1_Missense_Mutation_p.E253G	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	246										breast(1)	1																		---	---	---	---
PEG3	5178	broad.mit.edu	37	19	57333027	57333027	+	Silent	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57333027G>T	uc002qnu.2	-	4	1012	c.661C>A	c.(661-663)CGA>AGA	p.R221R	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Silent_p.R96R|ZIM2_uc002qnq.2_Silent_p.R96R|ZIM2_uc010etp.2_Silent_p.R96R|ZIM2_uc010ygs.1_Silent_p.R96R|PEG3_uc002qnt.2_Silent_p.R222R|PEG3_uc002qnv.2_Silent_p.R221R|PEG3_uc002qnw.2_Silent_p.R96R|PEG3_uc002qnx.2_Silent_p.R95R|PEG3_uc010etr.2_Silent_p.R221R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	221					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)														---	---	---	---
POFUT1	23509	broad.mit.edu	37	20	30818669	30818669	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30818669C>A	uc002wxp.2	+	6	832	c.783C>A	c.(781-783)TTC>TTA	p.F261L	POFUT1_uc010ztt.1_Missense_Mutation_p.F153L|POFUT1_uc010ztu.1_Missense_Mutation_p.F50L	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	261					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
C20orf71	128861	broad.mit.edu	37	20	31811670	31811670	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31811670C>A	uc002wyr.2	+	2	389	c.181C>A	c.(181-183)CAC>AAC	p.H61N	C20orf71_uc002wys.2_Missense_Mutation_p.H61N	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	61						extracellular region	lipid binding			ovary(1)|skin(1)	2																		---	---	---	---
KCNB1	3745	broad.mit.edu	37	20	48098748	48098748	+	Silent	SNP	G	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:48098748G>T	uc002xur.1	-	1	434	c.270C>A	c.(268-270)GGC>GGA	p.G90G	KCNB1_uc002xus.1_Silent_p.G90G	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	90	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)															---	---	---	---
KCNG1	3755	broad.mit.edu	37	20	49620871	49620871	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49620871C>A	uc002xwa.3	-	3	1542	c.1247G>T	c.(1246-1248)TGG>TTG	p.W416L		NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	416						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
C20orf195	79025	broad.mit.edu	37	20	62187890	62187890	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62187890G>A	uc002yfj.2	+	2	966	c.874G>A	c.(874-876)GTG>ATG	p.V292M	C20orf195_uc002yfk.2_Missense_Mutation_p.V292M	NM_024059	NP_076964	Q9BVV2	CT195_HUMAN	hypothetical protein LOC79025	292											0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)															---	---	---	---
BCOR	54880	broad.mit.edu	37	X	39932669	39932669	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:39932669C>A	uc004den.3	-	4	2222	c.1930G>T	c.(1930-1932)GAG>TAG	p.E644*	BCOR_uc004dep.3_Nonsense_Mutation_p.E644*|BCOR_uc004deo.3_Nonsense_Mutation_p.E644*|BCOR_uc004dem.3_Nonsense_Mutation_p.E644*|BCOR_uc004deq.3_Nonsense_Mutation_p.E644*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	644	Pro-rich.				heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4																		---	---	---	---
PAK3	5063	broad.mit.edu	37	X	110391110	110391110	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:110391110C>T	uc004epa.2	+	4	494	c.467C>T	c.(466-468)ACA>ATA	p.T156I	PAK3_uc010npt.1_Missense_Mutation_p.T141I|PAK3_uc010npu.1_Missense_Mutation_p.T141I|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_Missense_Mutation_p.T141I|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.T177I|PAK3_uc010npw.1_Missense_Mutation_p.T162I	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	156	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10															TSP Lung(19;0.15)			---	---	---	---
GPR112	139378	broad.mit.edu	37	X	135496392	135496392	+	Silent	SNP	G	T	T	rs150960878	byFrequency	TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135496392G>T	uc004ezu.1	+	25	9402	c.9111G>T	c.(9109-9111)CTG>CTT	p.L3037L	GPR112_uc010nsb.1_Silent_p.L2832L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	3037	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
HCFC1	3054	broad.mit.edu	37	X	153215694	153215694	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4455-01	TCGA-CG-4455-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153215694C>A	uc004fjp.2	-	24	6532	c.6004G>T	c.(6004-6006)GAA>TAA	p.E2002*		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	2002					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
